Li Lan

Journal Article Nat Commun · August 17, 2024 DSS1, essential for BRCA2-RAD51 dependent homologous recombination (HR), associates with the helical domain (HD) and OB fold 1 (OB1) of the BRCA2 DSS1/DNA-binding domain (DBD) which is frequently targeted by cancer-associated pathogenic variants. Herein, w ... Full text Link to item Cite

The beneficial effect of lauric acid addition in nucleation stage on the soot catalytic combustion performance of cerium-manganese catalyst

Journal Article Journal of Environmental Chemical Engineering · June 1, 2024 For cerium-manganese catalyst system, increasing the threshold of the amount of Mnx+ entering into the CeO2 lattice can generate more oxygen vacancies and adsorb more active oxygen species, thus promoting its soot catalytic combustion. However, this is dif ... Full text Cite

Transcription-coupled DNA repair protects genome stability upon oxidative stress-derived DNA strand breaks.

Journal Article FEBS Lett · May 30, 2024 Elevated oxidative stress, which threatens genome stability, has been detected in almost all types of cancers. Cells employ various DNA repair pathways to cope with DNA damage induced by oxidative stress. Recently, a lot of studies have provided insights i ... Full text Link to item Cite

Author Correction: Meiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repair.

Journal Article Nat Commun · May 7, 2024 Full text Link to item Cite

Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy.

Journal Article Med Res Rev · March 2024 Cancer continues to be a major health concern globally, although the advent of targeted therapy has revolutionized treatment options. Aurora Kinase B is a serine-threonine kinase that has been explored as an oncology therapeutic target for more than two de ... Full text Link to item Cite

Meiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repair.

Journal Article Nat Commun · February 21, 2024 Drugs targeting the DNA damage response (DDR) are widely used in cancer therapy, but resistance to these drugs remains a major clinical challenge. Here, we show that SYCP2, a meiotic protein in the synaptonemal complex, is aberrantly and commonly expressed ... Full text Link to item Cite

Effect of yttrium and manganese addition on catalytic soot combustion activity and anti-high-temperature stability of CeO2 catalyst

Journal Article Journal of Rare Earths · February 1, 2024 In order to analyze the influence of the addition of yttrium and manganese on the soot combustion performance and high temperature stability of CeO2 catalyst, a series of Y/Mn-modified CeO2 catalysts were prepared. The effects of structural properties, tex ... Full text Cite

The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export.

Journal Article Cell Rep · January 23, 2024 Fanconi anemia (FA) is characterized by congenital abnormalities, bone marrow failure, and cancer susceptibility. The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for interstrand crosslin ... Full text Link to item Cite

Research advance in the changes of bone mineral density during puberty

Journal Article Zhongguo Ertong Baojian Zazhi · January 10, 2024 Bone mineral density is an important indicator of bone nutrition. The bone mineral density of children gradually increases with age, and the accumulation of bone mineral density in adolescence increases significantly, which is the most sensitive period to ... Full text Cite

Synthesis of an Advanced Pd–Rh Bimetallic Three-Way Catalyst by Adjusting the Distribution of Noble Metals

Journal Article Russian Journal of Physical Chemistry A · December 1, 2023 Abstract: In recent years, the substantial increase in the prices of Pd and Rh brings about increasingly greater cost pressure for the exhaust gas aftertreatment industry, thus development of advanced Pd–Rh bimetallic catalysts with lower noble metal loadi ... Full text Cite

Pilot study of machine learning in the task of distinguishing high and low-grade pediatric hydronephrosis on ultrasound.

Journal Article Investig Clin Urol · November 2023 PURPOSE: Hydronephrosis is a common pediatric urological condition, characterized by dilation of the renal collecting system. Accurate identification of the severity of hydronephrosis is crucial in clinical management, as high-grade hydronephrosis can caus ... Full text Link to item Cite

ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy.

Journal Article Genes Dev · October 1, 2023 The mismatch repair (MMR) deficiency of cancer cells drives mutagenesis and offers a useful biomarker for immunotherapy. However, many MMR-deficient (MMR-d) tumors do not respond to immunotherapy, highlighting the need for alternative approaches to target ... Full text Link to item Cite

The RNA m5C modification in R-loops as an off switch of Alt-NHEJ.

Journal Article Nat Commun · September 30, 2023 The roles of R-loops and RNA modifications in homologous recombination (HR) and other DNA double-stranded break (DSB) repair pathways remain poorly understood. Here, we find that DNA damage-induced RNA methyl-5-cytosine (m5C) modification in R-loops plays ... Full text Link to item Cite

Radiomic and deep learning characterization of breast parenchyma on full field digital mammograms and specimen radiographs: a pilot study of a potential cancer field effect

Journal Article Journal of Medical Imaging · July 1, 2023 Purpose: In women with biopsy-proven breast cancer, histologically normal areas of the parenchyma have shown molecular similarity to the tumor, supporting a potential cancer field effect. The purpose of this work was to investigate relationships of human-e ... Full text Cite

The DACH1 gene is frequently deleted in prostate cancer, restrains prostatic intraepithelial neoplasia, decreases DNA damage repair, and predicts therapy responses.

Journal Article Oncogene · June 2023 Prostate cancer (PCa), the second leading cause of death in American men, includes distinct genetic subtypes with distinct therapeutic vulnerabilities. The DACH1 gene encodes a winged helix/Forkhead DNA-binding protein that competes for binding to FOXM1 si ... Full text Link to item Cite

Temporal Machine Learning Analysis of Prior Mammograms for Breast Cancer Risk Prediction.

Journal Article Cancers (Basel) · April 4, 2023 The identification of women at risk for sporadic breast cancer remains a clinical challenge. We hypothesize that the temporal analysis of annual screening mammograms, using a long short-term memory (LSTM) network, could accurately identify women at risk of ... Full text Link to item Cite

Effect of oxygen vacancy and highly dispersed MnOx on soot combustion in cerium manganese catalyst.

Journal Article Sci Rep · February 28, 2023 Cerium manganese bimetallic catalysts have become the focus of current research because of their excellent catalytic performance for soot combustion. Two series of cerium manganese catalysts (Na-free catalysts and Na-containing catalysts) were prepared by ... Full text Link to item Cite

Prognostic scoring system based on eosinophil- and basophil-related markers for predicting the prognosis of patients with stage II and stage III colorectal cancer: a retrospective cohort study

Journal Article Frontiers in Oncology · January 1, 2023 Background: Systemic inflammation is associated with the prognosis of colorectal cancer (CRC). The current study aimed to construct a comprehensively inflammatory prognostic scoring system named risk score (RS) based on eosinophil- and basophil-related mar ... Full text Cite

Novel integration of radiomics and deep transfer learning for diagnosis of indeterminate thyroid nodules on ultrasound

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2023 Identifying final pathology of FNA-indeterminate nodules before surgical resection could decrease the number of unnecessary surgeries and total cost to patients. This project explores how radiomics (RM) and deep learning (DTLM) models may be combined to im ... Full text Cite

Sources, resolution and physiological relevance of R-loops and RNA-DNA hybrids.

Journal Article Nat Rev Mol Cell Biol · August 2022 RNA-DNA hybrids are generated during transcription, DNA replication and DNA repair and are crucial intermediates in these processes. When RNA-DNA hybrids are stably formed in double-stranded DNA, they displace one of the DNA strands and give rise to a thre ... Full text Link to item Cite

DSS1 restrains BRCA2's engagement with dsDNA for homologous recombination, replication fork protection, and R-loop homeostasis.

The beneficial effect of lauric acid addition in nucleation stage on the soot catalytic combustion performance of cerium-manganese catalyst

Transcription-coupled DNA repair protects genome stability upon oxidative stress-derived DNA strand breaks.

Author Correction: Meiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repair.

Journal Article Nat Commun · May 7, 2024 Full text Link to item Cite

Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy.

Meiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repair.

Effect of yttrium and manganese addition on catalytic soot combustion activity and anti-high-temperature stability of CeO2 catalyst

The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export.

Research advance in the changes of bone mineral density during puberty

Synthesis of an Advanced Pd–Rh Bimetallic Three-Way Catalyst by Adjusting the Distribution of Noble Metals

Pilot study of machine learning in the task of distinguishing high and low-grade pediatric hydronephrosis on ultrasound.

ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy.

The RNA m5C modification in R-loops as an off switch of Alt-NHEJ.

Radiomic and deep learning characterization of breast parenchyma on full field digital mammograms and specimen radiographs: a pilot study of a potential cancer field effect

The DACH1 gene is frequently deleted in prostate cancer, restrains prostatic intraepithelial neoplasia, decreases DNA damage repair, and predicts therapy responses.

Temporal Machine Learning Analysis of Prior Mammograms for Breast Cancer Risk Prediction.

Effect of oxygen vacancy and highly dispersed MnOx on soot combustion in cerium manganese catalyst.

Prognostic scoring system based on eosinophil- and basophil-related markers for predicting the prognosis of patients with stage II and stage III colorectal cancer: a retrospective cohort study

Novel integration of radiomics and deep transfer learning for diagnosis of indeterminate thyroid nodules on ultrasound

Sources, resolution and physiological relevance of R-loops and RNA-DNA hybrids.

Effect of surface manganese oxide species on soot catalytic combustion of Ce–Mn–O catalyst

Journal Article Journal of Rare Earths · August 1, 2022 Constructing cerium and manganese bimetallic catalysts with excellent catalytic performance for soot combustion is the research frontier at present. In order to find out the key factors for catalytic soot combustion of Ce–Mn–O catalysts, a series of Ce–Mn– ... Full text Cite

Synthesis of an Advanced Pd–Rh Bimetallic Three-Way Catalyst for Gasoline Engine Emission Control with the Assistance of Citric Acid

Journal Article Russian Journal of Physical Chemistry A · June 1, 2022 Abstract: Citric acid was introduced into the Pd–Rh bimetallic catalyst system to achieve advanced three-way catalytic performance. The characterization results reveal that compared with bare Pd–Rh catalyst, the introduction of appropriate amount of citric ... Full text Cite

Author Correction: Sources, resolution and physiological relevance of R-loops and RNA-DNA hybrids.

Journal Article Nat Rev Mol Cell Biol · June 2022 Full text Link to item Cite

A machine-learning algorithm for distinguishing malignant from benign indeterminate thyroid nodules using ultrasound radiomic features

Journal Article Journal of Medical Imaging · May 1, 2022 Background: Ultrasound (US)-guided fine needle aspiration (FNA) cytology is the gold standard for the evaluation of thyroid nodules. However, up to 30% of FNA results are indeterminate, requiring further testing. In this study, we present a machine-learnin ... Full text Cite

Synthesis of Sr-modified Pd-Rh Bimetallic Catalyst with Advanced Three-Way Catalytic Performance

Journal Article Xiyou Jinshu Cailiao Yu Gongcheng/Rare Metal Materials and Engineering · April 1, 2022 A series of SrO-modified Pd-Rh/Al2O3 catalysts were synthesized by co-impregnation technique, i. e., Sr precursor was introduced into the mixed salt solution of Pd and Rh prior to their impregnation on Al2O3 powders. The results reveal that owing to the di ... Cite

Synthesis of a highly stable Pt/CeO2/Al2O3 catalyst for gasoline engine emission control by adjusting Pt distribution

Journal Article Canadian Journal of Chemical Engineering · April 1, 2022 For a CeO2/Al2O3-supported Pt catalyst system, the distribution of Pt is of significant importance to its hydrothermal stability and catalytic performance. Generally speaking, impregnation of a Pt precursor on CeO2/Al2O3 composite is a commonly applied app ... Full text Cite

FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation.

Journal Article Proc Natl Acad Sci U S A · March 22, 2022 RNA modifications regulate a variety of cellular processes including DNA repair.The RNA methyltransferase TRDMT1 generates methyl-5-cytosine (m5C) on messen-ger RNA (mRNA) at DNA double-strand breaks (DSBs) in transcribed regions, pro-moting transcription- ... Full text Link to item Cite

DNA repair defects in cancer and therapeutic opportunities.

Journal Article Genes Dev · March 1, 2022 DNA repair and DNA damage signaling pathways are critical for the maintenance of genomic stability. Defects of DNA repair and damage signaling contribute to tumorigenesis, but also render cancer cells vulnerable to DNA damage and reliant on remaining repai ... Full text Link to item Cite

Synthesis of an advanced Pd-Rh bimetallic catalyst for gasoline engine emission control

Journal Article Arabian Journal of Chemistry · February 1, 2022 In recent years, the dramatic increase of the prices of Pd and Rh brings about increasingly heavier cost pressure for the exhaust gas after-treatment industry, thus it is of great significance to develop advanced Pd-Rh bimetallic catalysts with low metal l ... Full text Cite

Dietary isoflavones intake is inversely associated with non-alcoholic fatty liver disease, hyperlipidaemia and hypertension.

Journal Article Int J Food Sci Nutr · February 2022 This study investigated associations between total isoflavones and their categories (daidzein, genistein, glycitein) intake and the risks for metabolic disorders. We used the data of 6786 Chinese adults from the Nutrition Health Atlas Project. We performed ... Full text Link to item Cite

Evaluation of Risk Factors for Chronic Obstructive Pulmonary Disease in the Middle-Aged and Elderly Rural Population of Northeast China Using Logistic Regression and Principal Component Analysis

Journal Article Risk Management and Healthcare Policy · January 1, 2022 Purpose: To investigate the environmental, immune, and inflammatory factors associated with chronic obstructive pulmonary disease (COPD) in middle-aged and older Chinese individuals. Patients and Methods: A community-based case–control study was conducted ... Full text Cite

Association between DCE MRI background parenchymal enhancement and mammographic texture features

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2022 Background parenchymal enhancement (BPE) from dynamic contrast-enhanced (DCE) MRI exams has been found in recent studies to be an indicator of breast cancer risk. To further understand the current framework of metrics to evaluate risk, we evaluated the ass ... Full text Cite

Immunostaining and Protein Pull-Down of Methyl-5-Cytosine-Marked RNA:DNA Hybrids.

Chapter · 2022 RNA:DNA hybrids not only function in various physiological cellular processes but also represent a threat to genome integrity. The methyl-5-cytosine (m5C) marked RNA:DNA hybrids containing the m5C modified RNA strand add another layer of regulation to the ... Full text Link to item Cite

Medical expenditure for lung cancer in China: a multicenter, hospital-based retrospective survey

Journal Article Cost Effectiveness and Resource Allocation · December 1, 2021 Background: Lung cancer is the most prevalent cancer, and the leading cause of cancer-related deaths in China. The aim of this study was to estimate the direct medical expenditure incurred for lung cancer care and analyze the trend therein for the period 2 ... Full text Cite

High-Resolution Full-3D Specimen Imaging for Lumpectomy Margin Assessment in Breast Cancer.

Journal Article Ann Surg Oncol · October 2021 BACKGROUND: Two-dimensional (2D) specimen radiography (SR) and tomosynthesis (DBT) for breast cancer yield data that lack high-depth resolution. A volumetric specimen imager (VSI) was developed to provide full-3D and thin-slice cross-sectional visualizatio ... Full text Link to item Cite

Optimized synthesis routes of mnox-zro2 hybrid catalysts for improved toluene combustion

Journal Article Catalysts · September 1, 2021 In this contribution, the three Mn-Zr catalysts with MnxZr1−xO2 hybrid phase were synthesized by two-step precipitation route (TP), conventional coprecipitation method (CP) and ball mill-ing process (MP). The components, textural and redox properties of th ... Full text Cite

Anatomic Point-Based Lung Region with Zone Identification for Radiologist Annotation and Machine Learning for Chest Radiographs.

Journal Article J Digit Imaging · August 2021 Our objective is to investigate the reliability and usefulness of anatomic point-based lung zone segmentation on chest radiographs (CXRs) as a reference standard framework and to evaluate the accuracy of automated point placement. Two hundred frontal CXRs ... Full text Link to item Cite

Highly effective self-propagating synthesis of lamellar ZnO-decorated MnO2 nanocrystals with improved supercapacitive performance

Journal Article Nanomaterials · July 1, 2021 A series of MOx (M = Co, Ni, Zn, Ce)-modified lamellar MnO2 electrode materials were controllably synthesized with a superfast self-propagating technology and their electrochemical practicability was evaluated using a three-electrode system. The results de ... Full text Cite

Effects of cancer treatment on household impoverishment: a multicentre cross-sectional study in China.

Journal Article BMJ Open · June 30, 2021 OBJECTIVES: To determine the incidence and intensity of household impoverishment induced by cancer treatment in China. DESIGN: Average income and daily consumption per capita of the households and out-of-pocket payments for cancer care were estimated. Hous ... Full text Link to item Cite

RNA transcripts stimulate homologous recombination by forming DR-loops.

Journal Article Nature · June 2021 Homologous recombination (HR) repairs DNA double-strand breaks (DSBs) in the S and G2 phases of the cell cycle1-3. Several HR proteins are preferentially recruited to DSBs at transcriptionally active loci4-10, but how transcription promotes HR is poorly un ... Full text Link to item Cite

Application of ultrasound-guided endoscopic retrograde appendicitis therapy in children with uncomplicated appendicitis

Journal Article Chinese Journal of Applied Clinical Pediatrics · May 20, 2021 Objective: To study the value of ultrasound-guided endoscopic retrograde appendicitis therapy in children with uncomplicated appendicitis. Methods: This study was a single center, retrospective study, including all electronic cases of appendicitis diagnose ... Full text Cite

Health-related quality of life of patients with colorectal neoplasms in China: A multicenter cross-sectional survey.

Journal Article J Gastroenterol Hepatol · May 2021 BACKGROUND AND AIM: This study aimed to clarify health-related quality of life (HRQoL) of patients with colorectal precancer and colorectal cancer (CRC) in China and to better understand related utility scores. METHODS: A hospital-based cross-sectional sur ... Full text Link to item Cite

Hereditary and breastfeeding factors are positively associated with the aetiology of mammary gland hyperplasia: a case-control study.

Journal Article Int Health · April 27, 2021 BACKGROUND: Hyperplasia of mammary gland (HMG) has become a common disorder in women. A family history of breast cancer and female reproductive factors may work together to increase the risk of HMG. However, this specific relationship has not been fully ch ... Full text Link to item Cite

Case Report: Multiple Seizures After a Diphenoxylate-Atropine Overdose in a Small Child

Journal Article Frontiers in Pharmacology · April 12, 2021 Poisoning is a type of accidental injury and it is considered a major public health problem worldwide. Oral drug poisoning in children is an important cause of accidental injury and even death. It is a common critical emergency in the field of pediatrics. ... Full text Cite

Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies.

Journal Article Mol Cell · March 4, 2021 Alternative lengthening of telomeres (ALT) is mediated by break-induced replication (BIR), but how BIR is regulated at telomeres is poorly understood. Here, we show that telomeric BIR is a self-perpetuating process. By tethering PML-IV to telomeres, we ind ... Full text Link to item Cite

Ubiquitination-mediated degradation of TRDMT1 regulates homologous recombination and therapeutic response

Journal Article NAR Cancer · March 1, 2021 The RNA methyltransferase TRDMT1 has recently emerged as a key regulator of homologous recombination (HR) in the transcribed regions of the genome, but how it is regulated and its relevance in cancer remain unknown. Here, we identified that TRDMT1 is poly- ... Full text Cite

Development of a thermally stable Pt catalyst by redispersion between CeO2and Al2O3

Journal Article RSC Advances · January 28, 2021 For catalytic systems consisting of Pt as the active component and CeO2-Al2O3as the support material, the metal-support interaction between the Pt and CeO2components is widely applied to inhibit aggregation of Pt species and thus enhance the thermal stabil ... Full text Cite

Parenchymal field effect analysis for breast cancer risk assessment: Evaluation of FFDM radiomic similarity

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2021 Histologically normal areas of the breast parenchyma have been shown to share molecular similarity with breast tumors, suggesting the presence of a field effect in breast cancer. To further understand a potential cancer field effect, we compared mammograph ... Full text Cite

Radiomic texture analysis for the assessment of osteoporosis on low-dose thoracic CT scans

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2021 In recent years, the assessment of non-cancerous diseases on low-dose CT scans for lung cancer screening has gained significant attention. Osteoporosis shares many risk factors with lung cancer and the thoracic and upper lumbar vertebrae can be visualized ... Full text Cite

Clinical analysis of 139 cases of infantile cow's milk protein allergy

Journal Article Zhongguo Ertong Baojian Zazhi · January 1, 2021 Objective To analyze the clinical characteristics and therapeutic effect of cow's milk protein allergy (CMPA) in infants, in order to improve the clinical diagnosis and treatment of CMPA. Methods A total of 139 infants with CMPA in Tangdu Hospital of Air F ... Full text Cite

Effects of AMPA receptor regulatory protein on the apoptosis of oligodendrocyte precursor cells under hypoxia and hypoglycemia conditions

Journal Article Chinese Journal of Applied Clinical Pediatrics · October 5, 2020 Objective: To observe the variation of glutamate(AMPA) receptor interacting protein(GRIPs)and apoptosis of oligodendrocyte precursor cells (OPCs)under oxygen glucose deprivation (OGD) condition, so as to explore the role of GRIPs in AMPA receptor-induced e ... Full text Cite

cGAS suppresses genomic instability as a decelerator of replication forks.

Journal Article Sci Adv · October 2020 The cyclic GMP-AMP synthase (cGAS), a sensor of cytosolic DNA, is critical for the innate immune response. Here, we show that loss of cGAS in untransformed and cancer cells results in uncontrolled DNA replication, hyperproliferation, and genomic instabilit ... Full text Link to item Cite

An ordered assembly of MYH glycosylase, SIRT6 protein deacetylase, and Rad9-Rad1-Hus1 checkpoint clamp at oxidatively damaged telomeres.

Journal Article Aging (Albany NY) · September 29, 2020 In the base excision repair pathway, MYH/MUTYH DNA glycosylase prevents mutations by removing adenine mispaired with 8-oxoG, a frequent oxidative lesion. MYH glycosylase activity is enhanced by Rad9-Rad1-Hus1 (9-1-1) checkpoint clamp and SIRT6 histone/prot ... Full text Link to item Cite

The deacetylase SIRT6 promotes the repair of UV-induced DNA damage by targeting DDB2.

Journal Article Nucleic Acids Res · September 18, 2020 The NAD+-dependent deacetylase and mono-ADP-ribosyl transferase SIRT6 stabilizes the genome by promoting DNA double strand break repair, thereby acting as a tumor suppressor. However, whether SIRT6 regulates nucleotide excision repair (NER) remains unknown ... Full text Link to item Cite

m5C modification of mRNA serves a DNA damage code to promote homologous recombination.

Journal Article Nat Commun · June 5, 2020 Recruitment of DNA repair proteins to DNA damage sites is a critical step for DNA repair. Post-translational modifications of proteins at DNA damage sites serve as DNA damage codes to recruit specific DNA repair factors. Here, we show that mRNA is locally ... Full text Link to item Cite

Resolution of ROS-induced G-quadruplexes and R-loops at transcriptionally active sites is dependent on BLM helicase.

Journal Article FEBS Lett · May 2020 R-loops and G-quadruplexes (G4s) are noncanonical secondary DNA structures. Here, we show that reactive oxygen species (ROS) induce G4 formation as well as R-loops at transcriptionally active sites. Importantly, the G4 structure is subsequently triggered b ... Full text Link to item Cite

Health-related quality of life in patients with esophageal cancer or precancerous lesions assessed by EQ-5D: A multicenter cross-sectional study.

Journal Article Thorac Cancer · April 2020 BACKGROUND: We aimed to obtain a set of health state utility scores of patients with esophageal cancer (EC) and precancerous lesions in China, and to explore the influencing factors of health-related quality of life (HRQoL). METHODS: A hospital-based multi ... Full text Link to item Cite

The DNA secondary structures at telomeres and genome instability

Journal Article Cell and Bioscience · March 26, 2020 Telomeric DNA are TTAGGG tandem repeats, which are susceptible for oxidative DNA damage and hotspot regions for formation of DNA secondary structures such as t-loop, D-loop, G-quadruplexes (G4), and R-loop. In the past two decades, unique DNA or RNA second ... Full text Cite

Preparation and Characterization of CeO2-based Oxygen Storage Materials

Journal Article Xiyou Jinshu Cailiao Yu Gongcheng/Rare Metal Materials and Engineering · March 1, 2020 Four types of CeO2-based oxide storage materials were prepared by co-precipitation, and their physicochemical properties were characterized by X-ray diffraction (XRD), Raman spectroscopy, N2 adsorption-desorption (BET), H2-temperature-programmed reduction ... Cite

An R-loop-initiated CSB-RAD52-POLD3 pathway suppresses ROS-induced telomeric DNA breaks.

Journal Article Nucleic Acids Res · February 20, 2020 Reactive oxygen species (ROS) inflict multiple types of lesions in DNA, threatening genomic integrity. How cells respond to ROS-induced DNA damage at telomeres is still largely unknown. Here, we show that ROS-induced DNA damage at telomeres triggers R-loop ... Full text Link to item Cite

Cigarette smoke exposure enhances transforming acidic coiled-coil-containing protein 2 turnover and thereby promotes emphysema.

Journal Article JCI Insight · January 30, 2020 Our integrative genomic and functional analysis identified transforming acidic coiled-coil-containing protein 2 (TACC2) as a chronic obstructive pulmonary disease (COPD) candidate gene. Here, we found that smokers with COPD exhibit a marked decrease in lun ... Full text Link to item Cite

Preliminary radiomic texture analysis of high-channel fluorescence confocal images of triple-negative breast cancer biopsies

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2020 Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by a high level of inflammation. In this work, we present a computational method for assessing immune activity across many populations of immune cells. For this an ... Full text Cite

Short-term impact of breast cancer screening intervention on health-related quality of life in China: A multicentre cross-sectional survey.

Journal Article Psychooncology · September 2019 OBJECTIVE: The impact of participating in breast cancer screening programmes on health-related quality of life (HRQoL)is poorly understood. METHODS: Based on a national breast cancer screening programme in China, a multicentre cross-sectional survey was co ... Full text Link to item Cite

Optimally designed synthesis of advanced Pd-Rh bimetallic three-way catalyst

Journal Article Canadian Journal of Chemical Engineering · September 1, 2019 For Pd-Rh bimetallic three-way catalysts, appropriate Pd-Rh interaction is of significant importance to the catalytic activity. In this work, an optimally designed approach was utilized to synthesize Pd-Rh bimetallic catalyst supported on CeO2-ZrO2-Al2O3 ( ... Full text Cite

Lipase-catalyzed synthesis of pH-responsive poly(β-thioether ester)-b-poly(ethylene glycol)-b-poly(β-thioether ester) amphiphilic triblock copolymers for drug delivery

Journal Article International Journal of Polymeric Materials and Polymeric Biomaterials · July 3, 2019 Novel amphiphilic triblock copolymers poly(β-thioether ester)-b-poly(ethylene glycol)-b-poly(β-thioether ester) (PTE-b-PEG-b-PTE) were designed for the first time and used as carriers for the sustained release of the hydrophobic drug curcumin (Cur). These ... Full text Cite

Phosphatase 1 Nuclear Targeting Subunit Mediates Recruitment and Function of Poly (ADP-Ribose) Polymerase 1 in DNA Repair.

Journal Article Cancer Res · May 15, 2019 PARP, particularly PARP1, plays an essential role in the detection and repair of DNA single-strand breaks and double-strand breaks. PARP1 accumulates at DNA damage sites within seconds after DNA damage to catalyze the massive induction of substrate protein ... Full text Link to item Cite

Radiomics robustness assessment and classification evaluation: A two-stage method demonstrated on multivendor FFDM.

Journal Article Med Phys · May 2019 PURPOSE: Radiomic texture analysis is typically performed on images acquired under specific, homogeneous imaging conditions. These controlled conditions may not be representative of the range of imaging conditions implemented clinically. We aim to develop ... Full text Link to item Cite

Digital Mammography in Breast Cancer: Additive Value of Radiomics of Breast Parenchyma.

Journal Article Radiology · April 2019 Background Previous studies have suggested that breast parenchymal texture features may reflect the biologic risk factors associated with breast cancer development. Therefore, combining the characteristics of normal parenchyma from the contralateral breast ... Full text Link to item Cite

Enhanced activity and hydrothermal stability of Rh-based three-way catalyst for emission control from motorcycles with the assistance of monoethanolamine

Journal Article Journal of Industrial and Engineering Chemistry · March 25, 2019 In this work, an advanced Rh/CeO2–ZrO2 (Rh/CZ) three-way catalyst was synthesized with the assistance of monoethanolamine. Compared with conventional Rh/CZ, the dispersion and oxidation state of Rh species, as well as the hydrothermal aging resistance are ... Full text Cite

Erratum: Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination.

Journal Article Genes Dev · February 1, 2019 Full text Link to item Cite

Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways.

Journal Article Cell Rep · January 22, 2019 Alternative lengthening of telomeres (ALT) is a telomerase-independent but recombination-dependent pathway that maintains telomeres. Here, we describe an assay to visualize ALT-mediated telomeric DNA synthesis in ALT-associated PML bodies (APBs) without DN ... Full text Link to item Cite

Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination.

Journal Article Cell Rep · January 15, 2019 Fanconi anemia (FA) is characterized by developmental abnormalities, bone marrow failure, and cancer predisposition. FA cells are hypersensitive to DNA replicative stress and accumulate co-transcriptional R-loops. Here, we use the Damage At RNA Transcripti ... Full text Link to item Cite

Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination.

Journal Article Genes Dev · January 1, 2019 Numerous DNA repair and signaling proteins function at DNA damage sites to protect the genome. Here, we show that fusion of the promiscuous biotin ligase BirAR118G with RAD18 leads to localized protein biotinylation at DNA damage sites, allowing identifica ... Full text Link to item Cite

Prognostic value of pre-treatment CT texture analysis in combination with change in size of the primary tumor in response to induction chemotherapy for HPV-positive oropharyngeal squamous cell carcinoma

Journal Article Quantitative Imaging in Medicine and Surgery · January 1, 2019 Background: To determine the additive value of quantitative radiomic texture features in predicting progression in human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) based on pre-treatment CT. Methods: Retrospective analysis ... Full text Cite

Quantifying site-specific chromatin mechanics and DNA damage response.

Journal Article Sci Rep · December 27, 2018 DNA double-strand breaks pose a direct threat to genomic stability. Studies of DNA damage and chromatin dynamics have yielded opposing results that support either increased or decreased chromatin motion after damage. In this study, we independently measure ... Full text Link to item Cite

ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB.

Journal Article Nat Commun · October 8, 2018 Actively transcribed regions of the genome are protected by transcription-coupled DNA repair mechanisms, including transcription-coupled homologous recombination (TC-HR). Here we used reactive oxygen species (ROS) to induce and characterize TC-HR at a tran ... Full text Link to item Cite

Preparation of CexZr1-xO2 with Combined Composition for Improved Pd-only Three-way Catalyst

Journal Article Wuji Cailiao Xuebao/Journal of Inorganic Materials · July 1, 2018 Two special CeO2-ZrO2 composites with combined compositions were prepared by a simple sequential precipitation method. The effect of the combination styles on properties of the supported Pd-only three-way catalysts was investigated by means of X-ray diffra ... Full text Cite

Optimized synthesis of highly thermal stable CeO2-ZrO2/Al2O3 composite for improved Pd-only three-way catalyst

Journal Article Materials and Design · June 5, 2018 As is well known, impregnation of precursors of Ce and Zr onto as-prepared Al2O3 powders is a commonly used approach to prepare CeO2-ZrO2/Al2O3 composite. In this work, a highly thermal stable CeO2-ZrO2/Al2O3 composite was synthesized by modifying the conv ... Full text Cite

Health-related quality of life and utility scores of patients with breast neoplasms in China: A multicenter cross-sectional survey.

Journal Article Breast · June 2018 BACKGROUND: Health-related quality of life and utility scores of patients with breast cancer and precancerous lesions are sparse in China. This study aimed to derive utility scores of patients with breast cancer and precancer in China. MATERIAL AND METHODS ... Full text Link to item Cite

Medical and non-medical expenditure for breast cancer diagnosis and treatment in China: a multicenter cross-sectional study.

Journal Article Asia Pac J Clin Oncol · June 2018 AIM: We aimed to assess economic burden of breast cancer (BC) diagnosis and treatment in China through a multicenter cross-sectional study, and to obtain theoretical evidence for policy-making. METHODS: This survey was conducted in 37 hospital centers acro ... Full text Link to item Cite

New insight into the microstructure–thermal stability relationships in ceria-zirconia solid solution and the application in Pd-only three-way catalyst

Journal Article Journal of Industrial and Engineering Chemistry · April 25, 2018 Three ceria-zirconia solid solutions were prepared by different synthesis routes. The results showed that CZ3 exhibited incompact structure with heterogeneous particle size distribution, accompanied by a bimodal pore size distribution. After aging treatmen ... Full text Cite

Medical expenses of urban Chinese patients with stomach cancer during 2002-2011: a hospital-based multicenter retrospective study.

Journal Article BMC Cancer · April 17, 2018 BACKGROUND: In China, stomach cancer is the third most common cancer and the third leading cause of cancer death. Few studies have examined Chinese stomach cancer patients' medical expenses and their associated trends. The Cancer Screening Program in Urban ... Full text Link to item Cite

CeO2–ZrO2–Al2O3 Modified by Selective Doping with SrO for Improved Pd-Only Three-Way Catalyst

Journal Article Russian Journal of Physical Chemistry A · April 1, 2018 Composite CeO2–ZrO2–Al2O3 (CZA) modified by selective doping with SrO was prepared by simple coprecipitation method. The characterization results reveal that the structural property of the modified sample is fundamentally different from that of undoped CZA ... Full text Cite

Designed synthesis of semi-embedded Pd over CeO2-ZrO2/Al2O3 as advanced three-way catalyst

Journal Article Journal of the Taiwan Institute of Chemical Engineers · April 1, 2018 For catalytic system consists of Pd as active component and CeO2-ZrO2/Al2O3 (CZ/A) as support, the dispersion and oxidation state of Pd species, which are crucial to the catalytic performance, are closely related to the metal-support interaction. In this w ... Full text Cite

SIRT6 facilitates directional telomere movement upon oxidative damage.

Journal Article Sci Rep · March 29, 2018 Oxidative damage to telomeres leads to telomere attrition and genomic instability, resulting in poor cell viability. Telomere dynamics contribute to the maintenance of telomere integrity; however, whether oxidative damage induces telomere movement and how ... Full text Link to item Cite

Facile synthesis of high surface area nanostructured ceria-zirconia-yttria-lanthana solid solutions with the assistance of lauric acid and dodecylamine

Journal Article Materials Research Bulletin · March 1, 2018 Co-precipitation combined with the assistance of lauric acid and dodecylamine was used to synthesize high surface area nanostructured ceria-zirconia-yttria-lanthana solid solutions (CZ-L and CZ-D). The promotion effects of lauric acid and dodecylamine were ... Full text Cite

ELL2 regulates DNA non-homologous end joining (NHEJ) repair in prostate cancer cells.

Journal Article Cancer Lett · February 28, 2018 ELL2 is an androgen-responsive gene that is expressed by prostate epithelial cells and is frequently down-regulated in prostate cancer. Deletion of Ell2 in the murine prostate induced murine prostatic intraepithelial neoplasia and ELL2 knockdown enhanced p ... Full text Link to item Cite

Controllable synthesis of zone-distributed Pd over CeO2–ZrO2/Al2O3 as advanced three-way catalyst

Journal Article Journal of Industrial and Engineering Chemistry · February 25, 2018 Two optimally designed catalysts (Ce0.7Zr0.3O2/Pd/Al2O3, Pd/Ce0.7Zr0.3O2/Pd/Al2O3) were synthesized and compared with conventional Pd/Ce0.7Zr0.3O2/Al2O3. The characterization results reveal that for Pd/Ce0.7Zr0.3O2/Al2O3, Pd species undergo severe agglomer ... Full text Cite

Short-term exposures to PM2.5 and cause-specific mortality of cardiovascular health in China.

Journal Article Environ Res · February 2018 BACKGROUND: Many multi-center epidemiological studies have robustly examined the acute health effects of exposure to low concentrations of fine particulate matter (PM2.5) on cardiovascular mortality in developed counties. However, data limitations have res ... Full text Link to item Cite

RAD52 is required for RNA-templated recombination repair in post-mitotic neurons.

Journal Article J Biol Chem · January 26, 2018 It has been long assumed that post-mitotic neurons only utilize the error-prone non-homologous end-joining pathway to repair double-strand breaks (DSBs) associated with oxidative damage to DNA, given the inability of non-replicating neuronal DNA to utilize ... Full text Link to item Cite

Deep learning in computer-aided diagnosis incorporating mammographic characteristics of both tumor and parenchyma stroma

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2018 We investigated the additive role of breast parenchyma stroma in the computer-aided diagnosis (CADx) of tumors on full-field digital mammograms (FFDM) by combining images of the tumor and contralateral normal parenchyma information via deep learning. The s ... Full text Cite

Dietary Sulfur-Containing Amino Acids Are Associated with Higher Prevalence of Overweight/Obesity in Northern Chinese Adults, an Internet-Based Cross-Sectional Study.

Journal Article Ann Nutr Metab · 2018 BACKGROUND/AIMS: Elevation of plasma sulfur-containing amino acids (SAAs) is generally associated with higher body mass index (BMI) and unfavorable lipid profiles. It is not known how dietary SAAs relate to these associations in humans. METHODS: A convenie ... Full text Link to item Cite

Deep learning in breast cancer risk assessment: Evaluation of fine-tuned convolutional neural networks on a clinical dataset of FFDMs

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2018 We evaluated the potential of deep learning in the assessment of breast cancer risk using convolutional neural networks (CNNs) fine-tuned on full-field digital mammographic (FFDM) images. This study included 456 clinical FFDM cases from two high-risk datas ... Full text Cite

Temporal assessment of radiomic features on clinical mammography in a high-risk population

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2018 Extraction of high-dimensional quantitative data from medical images has become necessary in disease risk assessment, diagnostics and prognostics. Radiomic workflows for mammography typically involve a single medical image for each patient although medical ... Full text Cite

Medical expenditure for liver cancer in urban China: A 10-year multicenter retrospective survey (2002-2011).

Journal Article J Cancer Res Ther · January 2018 OBJECTIVE: This study aims to understand the medical expenditure for liver cancer during 2002-2011 in urban areas of China. MATERIALS AND METHODS: This is a retrospective study. Based on a stratified cluster sampling method, a medical expenditure survey co ... Full text Link to item Cite

Promotional effect of Al 2 O 3 on WO 3 /CeO 2 -ZrO 2 monolithic catalyst for selective catalytic reduction of nitrogen oxides with ammonia after hydrothermal aging treatment

Journal Article Applied Surface Science · January 1, 2018 Hydrothermal stability of catalysts for selective catalytic reduction of NO x with NH 3 (NH 3 -SCR) has always been recognized as a challenge in development of candidate catalysts for applications in diesel engine emissions. In this study, Al 2 O 3 was int ... Full text Cite

Quantitative texture analysis: Robustness of radiomics across two digital mammography manufacturers' systems

Journal Article Journal of Medical Imaging · January 1, 2018 The robustness of radiomic texture analysis across different manufacturers of mammography imaging systems is investigated. We quantified feature robustness across mammography manufacturers using a dataset of 111 women who underwent consecutive screening ma ... Full text Cite

POT1 inhibits the efficiency but promotes the fidelity of nonhomologous end joining at non-telomeric DNA regions.

Journal Article Aging (Albany NY) · December 8, 2017 Robust DNA double strand break (DSB) repair and stabilized telomeres help maintain genome integrity, preventing the onset of aging or tumorigenesis. POT1 is one of the six factors in the shelterin complex, which protects telomeres from being recognized as ... Full text Link to item Cite

Cleavage of Ku80 by caspase-2 promotes non-homologous end joining-mediated DNA repair.

Journal Article DNA Repair (Amst) · December 2017 Non-homologous end-joining (NHEJ)-mediated repair of DNA double-strand breaks (DSBs) requires the formation of a Ku70/Ku80/DNA-PKcs complex at the DSB sites. A previous study has revealed Ku80 cleavage by caspase-3 during apoptosis. However, it remains lar ... Full text Link to item Cite

Regulation of DNA break repair by transcription and RNA.

Journal Article Sci China Life Sci · October 2017 Repair of DNA double-strand breaks (DSBs) via the homologous recombination (HR) pathway is a highly regulated process. A number of proteins that participate in HR are intricately modulated by the cell cycle and chromatin environments of DSBs. Recent studie ... Full text Link to item Cite

The oxidative DNA damage response: A review of research undertaken with Tsinghua and Xiangya students at the University of Pittsburgh.

Journal Article Sci China Life Sci · October 2017 Endogenous stress and exogenous toxicants (chemicals and UV light) alter genetic information either directly or indirectly through the production of reactive oxygen species (ROS), thereby driving genomic instability in cells and promoting tumorigenesis. Al ... Full text Link to item Cite

Temporal Relationship Between Hyperuricemia and Insulin Resistance and Its Impact on Future Risk of Hypertension.

Journal Article Hypertension · October 2017 Although hyperuricemia and insulin resistance significantly correlated, their temporal sequence and how the sequence influence on future risk of hypertension are largely unknown. This study assessed temporal relationship between uric acid and insulin resis ... Full text Link to item Cite

An in situ-forming phospholipid-based phase transition gel prolongs the duration of local anesthesia for ropivacaine with minimal toxicity.

Journal Article Acta Biomater · August 2017 UNLABELLED: An injectable, phospholipid-based phase transition gel (PPTG) has been developed for prolonging the release of ropivacaine (RO) for local anesthesia. PPTG was prepared by mixing phospholipids, medium-chain triglyceride and ethanol. Prior to inj ... Full text Link to item Cite

Preparation of CeO2–ZrO2–Al2O3 composite with layered structure for improved Pd-only three-way catalyst

Journal Article Journal of Materials Science · August 1, 2017 In this study, two CeO2–ZrO2–Al2O3 composites with layered structure were prepared by sequential precipitation route (SP) and compared with that obtained from conventional coprecipitation method (CC). The structural, textural and redox properties of the Pd ... Full text Cite

Public Perception of Extreme Cold Weather-Related Health Risk in a Cold Area of Northeast China.

Journal Article Disaster Med Public Health Prep · August 2017 OBJECTIVE: A need exists for public health strategies regarding extreme weather disasters, which in recent years have become more frequent. This study aimed to understand the public's perception of extreme cold and its related health risks, which may provi ... Full text Link to item Cite

SSRP1 Cooperates with PARP and XRCC1 to Facilitate Single-Strand DNA Break Repair by Chromatin Priming.

Journal Article Cancer Res · May 15, 2017 DNA single-strand breaks (SSB) are the most common form of DNA damage, requiring repair processes that to initiate must overcome chromatin barriers. The FACT complex comprised of the SSRP1 and SPT16 proteins is important for maintaining chromatin integrity ... Full text Link to item Cite

Remarkably promoted low-temperature reducibility and thermal stability of CeO2–ZrO2–La2O3–Nd2O3 by a urea-assisted low-temperature (90 °C) hydrothermal procedure

Journal Article Journal of Materials Science · May 1, 2017 Conventional co-precipitation combined with a urea-assisted low-temperature (90 °C) hydrothermal procedure (CZU) and the same method without urea (CZ) were used to prepare material CeO2–ZrO2–La2O3–Nd2O3. X-ray diffraction, Raman, nitrogen adsorption–desorp ... Full text Cite

The influence of H2O2 on the properties of CeO2-ZrO2 mixed oxides

Journal Article Journal of Materials Science · May 1, 2017 A series of ceria-zirconia (CZ) mixed oxides were prepared by coprecipitation, in which different amounts of H2O2 were added to investigate the influence of H2O2 on the properties of CZ. Modifications in structure, oxygen storage capacity, reducibility and ... Full text Cite

Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China: a hospital-based, multicenter, cross-sectional survey.

Journal Article Chin J Cancer · April 28, 2017 BACKGROUND: The increasing prevalence of colorectal cancer (CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed ... Full text Link to item Cite

Tankyrase1-mediated poly(ADP-ribosyl)ation of TRF1 maintains cell survival after telomeric DNA damage.

Journal Article Nucleic Acids Res · April 20, 2017 Oxidative DNA damage triggers telomere erosion and cellular senescence. However, how repair is initiated at telomeres is largely unknown. Here, we found unlike PARP1-mediated Poly-ADP-Ribosylation (PARylation) at genomic damage sites, PARylation at telomer ... Full text Link to item Cite

WRN is recruited to damaged telomeres via its RQC domain and tankyrase1-mediated poly-ADP-ribosylation of TRF1.

Journal Article Nucleic Acids Res · April 20, 2017 Werner syndrome (WS) is a progeroid-like syndrome caused by WRN gene mutations. WS cells exhibit shorter telomere length compared to normal cells, but it is not fully understood how WRN deficiency leads directly to telomere dysfunction. By generating local ... Full text Link to item Cite

The Threshold Temperature and Lag Effects on Daily Excess Mortality in Harbin, China: A Time Series Analysis.

Journal Article Int J Occup Environ Med · April 2017 BACKGROUND: A large number of studies have reported the relationship between ambient temperature and mortality. However, few studies have focused on the effects of high temperatures on cardio-cerebrovascular diseases mortality (CCVDM) and their acute event ... Full text Link to item Cite

Interactional effect of cerium and manganese on NO catalytic oxidation.

Journal Article Environ Sci Pollut Res Int · April 2017 To preferably catalyze the oxidation of NO to NO2 in diesel after-treatment system, a series of CeO2-MnO x composite oxides was supported on silica-alumina material by the co-impregnation method. The maximum conversion of NO of the catalyst with a Ce/Mn we ... Full text Link to item Cite

EAF2 regulates DNA repair through Ku70/Ku80 in the prostate.

Journal Article Oncogene · April 2017 Androgens are known to protect prostate cancer cells from DNA damage. Recent studies showed regulation of DNA repair genes by androgen receptor signaling in prostate cancers. ELL-associated factor 2 (EAF2) is an androgen-regulated tumor suppressor and its ... Full text Link to item Cite

Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1.

Journal Article Mol Cell · March 2, 2017 Telomeric repeat binding factor 1 (TRF1) is essential to the maintenance of telomere chromatin structure and integrity. However, how telomere integrity is maintained, especially in response to damage, remains poorly understood. Here, we identify Nek7, a me ... Full text Link to item Cite

Influence of extreme weather on years of life lost due to diabetes death in Chongqing and Harbin, China

Journal Article Chinese Journal of Endemiology · March 1, 2017 Objective: To understand the associations between extremely low and high air temperature and the years of life lost (YLL) due to diabetes deaths in Chongqing and Harbin with different climatic characteristics in China. Methods: A double threshold B-spline ... Full text Cite

Preparation of Ceria-zirconia Mixed Oxides with Improved Thermal Stability for Three-way Catalysts by a Modified Co-precipitation Method

Journal Article Wuji Cailiao Xuebao/Journal of Inorganic Materials · March 1, 2017 A series of ceria-zirconia mixed oxides (CZ-x; x=0, 20, 40 and 80) with Ce/Zr molar ratio of 3/2 were synthesized by co-precipitation method. In order to improve the thermal stability of ceria-zirconia mixed oxides, we extended the time for the primary gra ... Full text Cite

Promotional effect of Zr on thermal stability of CeTiOx monolith catalyst for selective catalytic reduction of NOx with ammonia

Journal Article Chinese Journal of Inorganic Chemistry · January 1, 2017 CeTiOx and CeZrTiOx catalysts were prepared by co-precipitation method and used for selective catalytic reduction of NOx by NH3 (NH3-SCR). Thermal aging of the two catalysts was conducted at various temperatures to investigate the effect of Zr on thermal s ... Full text Cite

Promotional effect of niobium substitution on the low-temperature activity of a WO3/CeZrOx monolithic catalyst for the selective catalytic reduction of NOx with NH3

Journal Article RSC Advances · January 1, 2017 A series of Nb-substituted WO3/CeZrOx catalysts were prepared by the co-impregnation method and applied in the selective catalytic reduction of NOx with NH3 (NH3-SCR). NH3 oxidation, N2 sorption, XRD, Raman, UV-vis, XPS, H2-TPR, O2/NH3-TPD and in situ DRIF ... Full text Cite

Induction of Site-Specific Oxidative Damage at Telomeres by Killerred-Fused Shelretin Proteins.

Chapter · 2017 Chronic oxidative stress is the major endogenous metabolic stress and contributes directly to telomere shortening and senescence. Understanding the dysfunction of telomeres under oxidative stress will greatly facilitate healthy aging and advance the treatm ... Full text Link to item Cite

Bcl-2 as a Therapeutic Target in Human Tubulointerstitial Inflammation.

Journal Article Arthritis Rheumatol · November 2016 OBJECTIVE: In lupus nephritis, tubulointerstitial inflammation (TII) is associated with in situ adaptive immune cell networks that amplify local tissue damage. Since conventional therapy appears ineffective for severe TII, and these patients often progress ... Full text Link to item Cite

The promotional effect of Ce on CuFe/beta monolith catalyst for selective catalytic reduction of NOx by ammonia

Journal Article Chemical Engineering Journal · October 15, 2016 The Cu3Fe3/beta and Cu3Fe3/Ce/beta catalysts were prepared by incipient wetness impregnation method, their activity, hydrothermal stability and C3H6 resistance for selective catalytic reduction of NOx with ammonia (NH3-SCR) were investigated systematically ... Full text Cite

Promotional effects of Zr on K⁺-poisoning resistance of CeTiOx catalyst for selective catalytic reductionof NOx with NH3

Journal Article Cuihua Xuebao/Chinese Journal of Catalysis · August 1, 2016 CeTiOx and CeZrTiOx catalysts were prepared by a coprecipitation method and used for selective catalytic reduction of NOx by NH3 (NH3-SCR). Various amounts of KNO3 were impregnated on the catalyst surface to investigate the effects of Zr addition on the K+ ... Full text Cite

Transcription-coupled homologous recombination after oxidative damage.

Journal Article DNA Repair (Amst) · August 2016 Oxidative DNA damage induces genomic instability and may lead to mutagenesis and carcinogenesis. As severe blockades to RNA polymerase II (RNA POLII) during transcription, oxidative DNA damage and the associated DNA strand breaks have a profoundly deleteri ... Full text Link to item Cite

The Lys63-deubiquitylating Enzyme BRCC36 Limits DNA Break Processing and Repair.

Journal Article J Biol Chem · July 29, 2016 Multisubunit protein assemblies offer integrated functionalities for efficient cell signal transduction control. One example of such protein assemblies, the BRCA1-A macromolecular complex, couples ubiquitin recognition and metabolism and promotes cellular ... Full text Link to item Cite

Preparation of CeO2-ZrO2-Al2O3 with a composite precipitant and its supported Pd-only three-way catalyst

Journal Article Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica · July 8, 2016 Acomposite precipitant composed of ammonia and ammoniumcarbonate was used to prepare CeO2- ZrO2-Al2O3 (CZA). For comparison, two other CZA samples were prepared using ammonia and ammonium carbonate as the precipitants, respectively. Differences in the text ... Full text Cite

Catalytic combustion of gasoline particulate soot over CeO2-ZrO2 catalysts

Journal Article Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica · July 8, 2016 A series of CeO2-ZrO2 mixed oxide catalysts having different mass ratios (wCeO2-(1–w)ZrO2) were prepared using a co-precipitation method and subsequently applied to the combustion of soot in gasoline engine exhaust. The soot combustion activities of the ca ... Full text Cite

Guarding chromosomes from oxidative DNA damage to the very end.

Journal Article Acta Biochim Biophys Sin (Shanghai) · July 2016 The ends of each chromosome are capped by the telomere assembly to protect chromosomal integrity from telomere attrition and DNA damage. In response to DNA damage, DNA repair factors are enriched at damage sites by a sophisticated signaling and recruitment ... Full text Link to item Cite

Modification of the thermal stability of doped CeO2–ZrO2 mixed oxides with the addition of triethylamine and its application as a Pd-only three-way catalyst

Journal Article Journal of Materials Science · May 1, 2016 In the present paper, triethylamine-assisted (CZS) and reference (CZ)-doped CeO2–ZrO2 mixed oxides were prepared by co-precipitation. The prepared samples were characterized by N2 adsorption–desorption, scanning electron microscopy (SEM), transmission elec ... Full text Cite

Using computer-extracted image phenotypes from tumors on breast magnetic resonance imaging to predict breast cancer pathologic stage.

Journal Article Cancer · March 1, 2016 BACKGROUND: The objective of this study was to demonstrate that computer-extracted image phenotypes (CEIPs) of biopsy-proven breast cancer on magnetic resonance imaging (MRI) can accurately predict pathologic stage. METHODS: The authors used a data set of ... Full text Link to item Cite

Novel promotional effect of yttrium on Cu-SAPO-34 monolith catalyst for selective catalytic reduction of NOx by NH3 (NH3-SCR)

Journal Article Catalysis Communications · February 10, 2016 Cu-SAPO-34 and CuY-SAPO-34 catalysts for NH3-SCR were prepared by the wet-impregnation method. XRD, UV-vis DRS, ESR and NH3-TPD results showed that the introduction of Y effectively improved the dispersion of copper species, increased the amount of isolate ... Full text Cite

Fast and precise 3D fluorophore localization by gradient fitting

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2016 Astigmatism imaging is widely used to encode the 3D position of fluorophore in single-particle tracking and super-resolution localization microscopy. Here, we present a fast and precise localization algorithm based on gradient fitting to decode the 3D subp ... Full text Cite

Effect of surface tension on the properties of a doped CeO2-ZrO2 composite and its application in a Pd-only three-way catalyst

Journal Article RSC Advances · January 1, 2016 La and Pr modified ceria-zirconia solid solution materials CeO2-ZrO2-La2O3-Pr6O11 (CZLP) were synthesized through a co-precipitation method, in which the influence of surface tension during the drying process on the textural/structural properties, reductio ... Full text Cite

Promotion of CeO2-ZrO2-Al2O3 composite by selective doping with barium and its supported Pd-only three-way catalyst

Journal Article Journal of Molecular Catalysis A: Chemical · December 15, 2015 In this work, CeO2-ZrO2-Al2O3 (CZA) composites promoted by selective doping with Ba were prepared by simple coprecipitation method. The structural characterization results reveal that with small doping amount (≤6 wt%), Ba can preferentially combine with Al ... Full text Cite

Deciphering Genomic Underpinnings of Quantitative MRI-based Radiomic Phenotypes of Invasive Breast Carcinoma.

Journal Article Sci Rep · December 7, 2015 Magnetic Resonance Imaging (MRI) has been routinely used for the diagnosis and treatment of breast cancer. However, the relationship between the MRI tumor phenotypes and the underlying genetic mechanisms remains under-explored. We integrated multi-omics mo ... Full text Link to item Cite

The modification of Ag/Al2O3 catalyst and application of combined catalysts in methanol-SCR of NO

Journal Article Canadian Journal of Chemical Engineering · December 1, 2015 In this paper, a series of Wx/Ag/Al2O3 catalysts with different tungsten contents (0, 0.04, 0.06, 0.08, and 0.10g/g) and 0.03g/g silver for selective catalytic reduction of NO with methanol under excess oxygen (methanol-SCR), were prepared with a tradition ... Full text Cite

Prediction of clinical phenotypes in invasive breast carcinomas from the integration of radiomics and genomics data

Journal Article Journal of Medical Imaging · October 1, 2015 Genomic and radiomic imaging profiles of invasive breast carcinomas from The Cancer Genome Atlas and The Cancer Imaging Archive were integrated and a comprehensive analysis was conducted to predict clinical outcomes using the radiogenomic features. Variabl ... Full text Cite

Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis.

Journal Article Nat Commun · September 30, 2015 KLF4 is an important regulator of cell-fate decision, including DNA damage response and apoptosis. We identify a novel interplay between protein modifications in regulating KLF4 function. Here we show that arginine methylation of KLF4 by PRMT5 inhibits KLF ... Full text Link to item Cite

Fast and Precise 3D Fluorophore Localization based on Gradient Fitting.

Journal Article Sci Rep · September 22, 2015 Astigmatism imaging approach has been widely used to encode the fluorophore's 3D position in single-particle tracking and super-resolution localization microscopy. Here, we present a new high-speed localization algorithm based on gradient fitting to precis ... Full text Link to item Cite

Regulation of DNA Damage Signaling and Cell Death Responses by Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) and LMP2A in Nasopharyngeal Carcinoma Cells.

Journal Article J Virol · August 2015 UNLABELLED: Nasopharyngeal carcinoma (NPC) is closely associated with latent Epstein-Barr virus (EBV) infection. Although EBV infection of preneoplastic epithelial cells is not immortalizing, EBV can modulate oncogenic and cell death mechanisms. The viral ... Full text Link to item Cite

Targeted DNA damage at individual telomeres disrupts their integrity and triggers cell death.

Journal Article Nucleic Acids Res · July 27, 2015 Cellular DNA is organized into chromosomes and capped by a unique nucleoprotein structure, the telomere. Both oxidative stress and telomere shortening/dysfunction cause aging-related degenerative pathologies and increase cancer risk. However, a direct conn ... Full text Link to item Cite

DNA damage during the G0/G1 phase triggers RNA-templated, Cockayne syndrome B-dependent homologous recombination.

Journal Article Proc Natl Acad Sci U S A · July 7, 2015 Damage repair mechanisms at transcriptionally active sites during the G0/G1 phase are largely unknown. To elucidate these mechanisms, we introduced genome site-specific oxidative DNA damage and determined the role of transcription in repair factor assembly ... Full text Link to item Cite

New insights into the structure of a CeO2-ZrO2-Al2O3 composite and its influence on the performance of the supported Pd-only three-way catalyst

Journal Article Catalysis Science and Technology · July 6, 2015 In this work, a Ce0.5Zr0.5O2-Al2O3 (CZA) mixed oxide prepared by a coprecipitation method was deeply investigated and some new insights into the microstructure were obtained. The XRD, Raman, TEM and XPS results revealed that compositional inhomogeneity exi ... Full text Cite

Cerium promotion on the hydrocarbon resistance of a Cu-SAPO-34 NH3-SCR monolith catalyst

Journal Article Catalysis Science and Technology · July 6, 2015 CuCe-SAPO-34 (CuCe-x) catalysts with 3 wt% Cu and various content of Ce for selective catalytic reduction of NOx by NH3 (NH3-SCR) were prepared by a wet co-impregnation method. The activities of the CuCe-x catalysts were better than that of Cu-SAPO-34 (Cu) ... Full text Cite

Preparation of ceria-zirconia by modified coprecipitation method and its supported Pd-only three-way catalyst

Journal Article Journal of Colloid and Interface Science · July 5, 2015 A CeO2-ZrO2 compound with mixed phase composition (CZ4) was prepared by modified co-precipitation method, and for comparison, single-phase Ce0.2Zr0.8O2, Ce0.5Zr0.5O2 an ... Full text Cite

ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors.

Journal Article Cancer Discov · July 2015 UNLABELLED: ARID1A, SWI/SNF chromatin remodeling complex subunit, is a recently identified tumor suppressor that is mutated in a broad spectrum of human cancers. Thus, it is of fundamental clinical importance to understand its molecular functions and deter ... Full text Link to item Cite

Effectively enhance catalytic performance by adjusting pH during the synthesis of active components over FeVO4/TiO2-WO3-SiO2 monolith catalysts

Journal Article Chemical Engineering Journal · July 1, 2015 The effect of pH during co-precipitation on the structural and physicochemical properties of a FeVO4/TiO2-WO3-SiO2 catalyst was investigated by using XRD, SEM, HR-TEM, BET, TPD, TPR and XPS. The as-prepared catalysts were tested in an NH3-SCR reaction with ... Full text Cite

SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9-Rad1-Hus1 checkpoint clamp.

Journal Article BMC Mol Biol · June 11, 2015 BACKGROUND: SIRT6, a member of the NAD(+)-dependent histone/protein deacetylase family, regulates genomic stability, metabolism, and lifespan. MYH glycosylase and APE1 are two base excision repair (BER) enzymes involved in mutation avoidance from oxidative ... Full text Link to item Cite

[Acceptance and willingness-to-pay for colorectal colonoscopy screening among high-risk populations for colorectal cancer in urban China].

Journal Article Zhonghua Yu Fang Yi Xue Za Zhi · May 2015 OBJECTIVE: To survey the acceptance and willingness-to-pay for colorectal cancer colonoscopy screening among high risk populations in urban China. METHODS: From 2012 to 2013, a Cancer Screening Program in Urban China (CanSPUC) was initiated in 9 provinces, ... Link to item Cite

Synthesis of Zirconia-Palladium Core-Shell Nanoparticles as Three-Way Catalysts

Journal Article Catalysis Letters · April 23, 2015 Zirconia-palladium (ZrO2-Pd) core-shell nanoparticles were synthesized by two different methods, namely, hydrothermal and common precipitation method. A non-ionic surfactant polyvinylpyrrolidone was used as dispersant while ammonia solution as precipitator ... Full text Cite

FeVO4 nanorods supported TiO2 as a superior catalyst for NH3-SCR reaction in a broad temperature range

Journal Article Catalysis Communications · April 5, 2015 In this work, a catalyst with FeVO4 nanorods supported on TiO2 was prepared and applied for NH3-SCR reaction. A significantly enhanced low temperature catalytic activity has been achieved in the presence of 10% H2O with the active window shifting by 15 °C ... Full text Cite

Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining.

Journal Article Mol Cell · April 2, 2015 Nonhomologous end-joining (NHEJ) is a major DNA double-strand break repair pathway that is conserved in eukaryotes. In vertebrates, NHEJ further acquires end-processing capacities (e.g., hairpin opening) in addition to direct end-ligation. The catalytic su ... Full text Link to item Cite

Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway.

Journal Article Nat Commun · February 11, 2015 Non-homologous end joining (NHEJ) is a major pathway to repair DNA double-strand breaks (DSBs), which can display different types of broken ends. However, it is unclear how NHEJ factors organize to repair diverse types of DNA breaks. Here, through systemat ... Full text Link to item Cite

Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response.

Journal Article Cell Res · February 2015 Ataxia telangiectasia mutated (ATM) mediates DNA damage response by controling irradiation-induced foci formation, cell cycle checkpoint, and apoptosis. However, how upstream signaling regulates ATM is not completely understood. Here, we show that upon irr ... Full text Link to item Cite

Ce-Zr-La/Al2O3 prepared in a continuous stirred-tank reactor: A highly thermostable support for an efficient Rh-based three-way catalyst

Journal Article Dalton Transactions · January 1, 2015 Two Ce-Zr-La/Al2O3 composite oxides, CZLA-C and CZLA-B, were synthesized using a co-precipitation method in a continuous stirred-tank reactor (CSTR) and a batch reactor (BR), respectively. Two Rh-based three-way catalysts (TWCs), Rh/CZLA-C and Rh/CZLA-B we ... Full text Cite

The Harbin Cohort Study on Diet, Nutrition and Chronic Non-communicable Diseases: study design and baseline characteristics.

Journal Article PLoS One · 2015 Diet and nutrition have been reported to be associated with many common chronic diseases and blood-based assessment would be vital to investigate the association and mechanism, however, blood-based prospective studies are limited. The Harbin Cohort Study o ... Full text Link to item Cite

Optimal cut-off points of fasting plasma glucose for two-step strategy in estimating prevalence and screening undiagnosed diabetes and pre-diabetes in Harbin, China.

Journal Article PLoS One · 2015 To identify optimal cut-off points of fasting plasma glucose (FPG) for two-step strategy in screening abnormal glucose metabolism and estimating prevalence in general Chinese population. A population-based cross-sectional study was conducted on 7913 people ... Full text Link to item Cite

Promotional effect of Ce on Cu-SAPO-34 monolith catalyst for selective catalytic reduction of NOx with ammonia

Journal Article Journal of Molecular Catalysis A: Chemical · January 1, 2015 The activity and hydrothermal stability of Cu-SAPO-34 and CuCe-SAPO-34 for selective catalytic reduction of NOx with ammonia (NH3-SCR) were investigated systematically. The catalysts were prepared by wet-impregnation method, and characterized by N2 adsorpt ... Full text Cite

RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1.

Journal Article Mol Cell Biol · January 2015 Efficient DNA double-strand break (DSB) repair is critical for the maintenance of genome stability. Unrepaired or misrepaired DSBs cause chromosomal rearrangements that can result in severe consequences, such as tumorigenesis. RAD6 is an E2 ubiquitin-conju ... Full text Link to item Cite

Selective catalytic oxidation of ammonia to nitrogen over iron and copper bimetallic catalysts

Journal Article Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica · November 27, 2014 Iron and copper bimetallic catalysts with fixed total contents of copper and iron were prepared by a co-impregnation method, and then used for selective catalytic oxidation of ammonia to nitrogen. The properties of the catalysts were characterized by N2 ad ... Full text Cite

HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β.

Journal Article Nat Commun · November 26, 2014 Cellular DNA repair processes are crucial to maintain genome stability and integrity. In DNA base excision repair, a tight heterodimer complex formed by DNA polymerase β (Polβ) and XRCC1 is thought to facilitate repair by recruiting Polβ to DNA damage site ... Full text Link to item Cite

The effect of synthesis method on the properties and catalytic performance of Pd/Ce0.5Zr0.5O2-Al2O3 three-way catalyst

Journal Article Journal of Molecular Catalysis A: Chemical · November 15, 2014 Three Ce0.5Zr0.5O2-Al2O 3 compounds were prepared using conventional coprecipitation method, mechanical mixing technique and a novel modified coprecipitation route, afterwards the corresponding Pd-only three-way catalysts were obtained by wet-impregnation ... Full text Cite

Comparative analysis of image-based phenotypes of mammographic density and parenchymal patterns in distinguishing between BRCA1/2 cases, unilateral cancer cases, and controls

Journal Article Journal of Medical Imaging · October 1, 2014 We statistically compare the contributions of parenchymal phenotypes to mammographic density in distinguishing between high-risk cases and low-risk controls. The age-matched evaluation included computerized mammographic assessment of breast percent density ... Full text Cite

Extremely cold and hot temperatures increase the risk of diabetes mortality in metropolitan areas of two Chinese cities.

Journal Article Environ Res · October 2014 BACKGROUND: Numerous studies have reported the association between ambient temperature and mortality. However, few studies have focused on the effects of extreme temperatures on diabetes mortality, particularly in China. The objective of the present study ... Full text Link to item Cite

A new monolithic Pt-Pd-Rh motorcycle exhaust catalyst to meet future emission standards

Journal Article Cuihua Xuebao/Chinese Journal of Catalysis · September 1, 2014 A new composite oxide material as support, CeO2-ZrO2-La2O3-PrO2-Al2O3, was synthesized by a co-precipitation method. Pd-Rh, Pt-Rh, and Pt-Pd-Rh supported on monolithic carrier catalysts were obtained by an impregnation route. The textural, structural, and ... Full text Cite

Pilot study demonstrating potential association between breast cancer image-based risk phenotypes and genomic biomarkers.

Journal Article Med Phys · March 2014 PURPOSE: In this pilot study, the authors examined associations between image-based phenotypes and genomic biomarkers. The potential genetic contribution of UGT2B genes to interindividual variation in breast density and mammographic parenchymal patterns is ... Full text Link to item Cite

Novel method for site-specific induction of oxidative DNA damage reveals differences in recruitment of repair proteins to heterochromatin and euchromatin.

Journal Article Nucleic Acids Res · February 2014 Reactive oxygen species (ROS)-induced DNA damage is repaired by the base excision repair pathway. However, the effect of chromatin structure on BER protein recruitment to DNA damage sites in living cells is poorly understood. To address this problem, we de ... Full text Link to item Cite

Damage-dependent regulation of MUS81-EME1 by Fanconi anemia complementation group A protein.

Journal Article Nucleic Acids Res · February 2014 MUS81-EME1 is a DNA endonuclease involved in replication-coupled repair of DNA interstrand cross-links (ICLs). A prevalent hypothetical role of MUS81-EME1 in ICL repair is to unhook the damage by incising the leading strand at the 3' side of an ICL lesion. ... Full text Link to item Cite

A chemical probe targets DNA 5-formylcytosine sites and inhibits TDG excision, polymerases bypass, and gene expression

Journal Article Chemical Science · February 1, 2014 Dynamic regulation and faithful maintenance of proper DNA methylation patterns are essential for many cellular functions. 5-Formylcytosine (5fC), a newly discovered oxidized form of methylcytosine (mC), is involved in active DNA demethylation processes. Th ... Full text Cite

Relationships between computer-extracted mammographic texture pattern features and BRCA1/2 mutation status: a cross-sectional study.

Journal Article Breast Cancer Res · 2014 INTRODUCTION: Mammographic density is similar among women at risk of either sporadic or BRCA1/2-related breast cancer. It has been suggested that digitized mammographic images contain computer-extractable information within the parenchymal pattern, which m ... Full text Link to item Cite

Quantitative MRI phenotyping of breast cancer across molecular classification subtypes

Conference Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · January 1, 2014 The goal of our study was to investigate the potential usefulness of quantitative MRI analysis (i.e., phenotyping) in characterizing and data mining the molecular subtypes of breast cancer in order to better understand the difference among HER2, ER, and PR ... Full text Cite

Ubiquitin-specific protease 5 is required for the efficient repair of DNA double-strand breaks.

Journal Article PLoS One · 2014 During the DNA damage response (DDR), ubiquitination plays an important role in the recruitment and regulation of repair proteins. However, little is known about elimination of the ubiquitination signal after repair is completed. Here we show that the ubiq ... Full text Link to item Cite

Potential of computer-aided diagnosis of high spectral and spatial resolution (HiSS) MRI in the classification of breast lesions.

Journal Article J Magn Reson Imaging · January 2014 PURPOSE: To compare the performance of computer-aided diagnosis (CADx) analysis of precontrast high spectral and spatial resolution (HiSS) MRI to that of clinical dynamic contrast-enhanced MRI (DCE-MRI) in the diagnostic classification of breast lesions. M ... Full text Link to item Cite

Damage response of XRCC1 at sites of DNA single strand breaks is regulated by phosphorylation and ubiquitylation after degradation of poly(ADP-ribose).

Journal Article J Cell Sci · October 1, 2013 Single-strand breaks (SSBs) are the most common type of oxidative DNA damage and they are related to aging and many genetic diseases. The scaffold protein for repair of SSBs, XRCC1, accumulates at sites of poly(ADP-ribose) (pAR) synthesized by PARP, but it ... Full text Link to item Cite

The expression of Cx32 and Cx43 in the hippocampus of PTZ-kindled epileptic rats

Journal Article Journal of Xi'an Jiaotong University (Medical Sciences) · July 1, 2013 Objective: To investigate the changes of neurons, astrocytes and their connexin in PTZ-kindled rats as well as the effect of carbenoxolone (CBX) on gap junction. Methods: Totally 30 male SD rats were randomly divided into normal saline (NS) group, kindled ... Cite

Preparation of mesoporous CeO2 with high thermal stability by ammonium carbonate hydrolysis method

Journal Article Chinese Journal of Inorganic Chemistry · January 1, 2013 Two series of CeO2 materials were prepared by two different synthetic routes, i.e. the conventional ammonia precipitation route (CR) and the ammonium carbonate hydrolysis route (HA) using (NH4)2CO3 in the presence of hydrogen peroxide. The formation proces ... Full text Cite

Computerized analysis of mammographic parenchymal patterns on a large clinical dataset of full-field digital mammograms: robustness study with two high-risk datasets.

Journal Article J Digit Imaging · October 2012 The purpose of this study was to demonstrate the robustness of our prior computerized texture analysis method for breast cancer risk assessment, which was developed initially on a limited dataset of screen-film mammograms. This current study investigated t ... Full text Link to item Cite

[A preliminary study on the effects of meteorological factors on intracerebral hemorrhage death using the BP neural network model].

Journal Article Zhonghua Liu Xing Bing Xue Za Zhi · September 2012 OBJECTIVE: Using the Back Propagation (BP) Neural Network Model to discover the relationship between meteorological factors and mortality of intracerebral hemorrhage, to provide evidence for developing an intracerebral hemorrhage prevention and control pro ... Link to item Cite

Increased mortality during the 2010 heat wave in Harbin, China.

Journal Article Ecohealth · September 2012 In this study, we investigated the effect on daily mortality of a 2010 heat wave in the city of Harbin in northern China. We calculated mortality rate ratios (RRs) by comparing the number of deaths during the heat wave period (June 7th-11th, 2010) to the n ... Full text Link to item Cite

Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase.

Journal Article J Biol Chem · April 6, 2012 How the nucleotide excision repair (NER) machinery gains access to damaged chromatinized DNA templates and how the chromatin structure is modified to promote efficient repair of the non-transcribed genome remain poorly understood. The UV-damaged DNA-bindin ... Full text Link to item Cite

Preperation of high performance Ce 0.5Zr 0.5O 2 rare earth oxygen storage material and its supported Pd-only three-way catalyst

Journal Article Cuihua Xuebao/Chinese Journal of Catalysis · February 1, 2012 A series of Ce 0.5Zr 0.5O 2 oxygen storage material samples were prepared by co-precipitation using ammonium carbonate as precipitant. The effect of the concentration of the salt solution on the performance of the target materials and its supported Pd-only ... Full text Cite

TU‐E‐217BCD‐07: Pilot Study on Consistency in Size Metrics for a Multimodality PEM/MR Breast Imaging Approach

Conference Medical Physics · January 1, 2012 Purpose: In this study, we evaluated the degree of consistency between size metrics obtained from PEM and MRI to determine the intrinsic effectiveness of a multimodality approach using these two systems for breast imaging. Methods: Under an IRB‐approved pr ... Full text Cite

Effect of zirconium precursor on performance of Pd/Ce0.45Zr0.45La0.1O1.95 three-way catalyst

Journal Article Cuihua Xuebao/Chinese Journal of Catalysis · January 1, 2012 Three types of Ce0.45Zr0.45La0.1O1.95 mixed oxides were prepared by H2O2-assisted precipitation using ZrOCO3, ZrO(NO3)2, and Zr(NO3)4 as precursors. The Pd/Ce0.45Zr0.45La0.1O1.95 three-way catalysts were prepared by the wet impregnation and characterized b ... Full text Cite

A two-step precipitation route to CeO2 material with improved thermal stability and reduction property

Journal Article Chinese Journal of Inorganic Chemistry · January 1, 2012 Two series of CeO2 samples were prepared by two different synthetic routes: one was conventional precipitation route employing ammonia as reactant, and the other was a two-step precipitation procedure, using ammonium carbonate ((NH4)2CO3) as precipitant at ... Cite

Long-term culture and cryopreservation of interstitial cells of Cajal.

Journal Article Scand J Gastroenterol · January 2012 OBJECTIVE: Interstitial cells of Cajal (ICCs) in the gastrointestinal tract generate and propagate slow waves and mediate neuromuscular neurotransmission. Damage to ICCs has been described in several gastrointestinal motor disorders, and although many stud ... Full text Link to item Cite

BRCA1 contributes to transcription-coupled repair of DNA damage through polyubiquitination and degradation of Cockayne syndrome B protein.

Journal Article Cancer Sci · October 2011 BRCA1 is an important gene involved in susceptibility to breast and ovarian cancer and its product regulates the cellular response to DNA double-strand breaks. Here, we present evidence that BRCA1 also contributes to the transcription-coupled repair (TCR) ... Full text Link to item Cite

Computerized three-class classification of MRI-based prognostic markers for breast cancer.

Journal Article Phys Med Biol · September 21, 2011 The purpose of this study is to investigate whether computerized analysis using three-class Bayesian artificial neural network (BANN) feature selection and classification can characterize tumor grades (grade 1, grade 2 and grade 3) of breast lesions for pr ... Full text Link to item Cite

Combined use of T2-weighted MRI and T1-weighted dynamic contrast-enhanced MRI in the automated analysis of breast lesions.

Journal Article Magn Reson Med · August 2011 A multiparametric computer-aided diagnosis scheme that combines information from T1-weighted dynamic contrast-enhanced (DCE)-MRI and T2-weighted MRI was investigated using a database of 110 malignant and 86 benign breast lesions. Automatic lesion segmentat ... Full text Link to item Cite

[Motilin receptor expression in the interstitial cells of Cajal].

Journal Article Zhonghua Er Ke Za Zhi · April 2011 OBJECTIVE: To look for the evidences of motilin receptor expression on interstitial cells of Cajal (ICC) of the rabbit. METHOD: Smooth muscle segments with ICC were isolated from the small intestine of 10-day old rabbits. The tissue segments equilibrated i ... Link to item Cite

Evaluation of clinical breast MR imaging performed with prototype computer-aided diagnosis breast MR imaging workstation: reader study.

Journal Article Radiology · March 2011 PURPOSE: To evaluate a computer-aided diagnosis (CADx) system for dynamic contrast material-enhanced magnetic resonance (MR) imaging and compare it with a currently used clinical method of interpreting breast MR image findings that includes the use of comm ... Full text Link to item Cite

Mutant Cockayne syndrome group B protein inhibits repair of DNA topoisomerase I-DNA covalent complex.

Journal Article Genes Cells · January 2011 Two UV-sensitive syndrome patients who have mild photosensitivity without detectable somatic abnormalities lack detectable Cockayne syndrome group B (CSB) protein because of a homozygous null mutation in the CSB gene. In contrast, mutant CSB proteins are p ... Full text Link to item Cite

The ACF1 complex is required for DNA double-strand break repair in human cells.

Journal Article Mol Cell · December 22, 2010 DNA double-strand breaks (DSBs) are repaired via nonhomologous end-joining (NHEJ) or homologous recombination (HR), but cellular repair processes remain elusive. We show here that the ATP-dependent chromatin-remodeling factors, ACF1 and SNF2H, accumulate r ... Full text Link to item Cite

Validation of mammographic texture analysis for assessment of breast cancer risk

Conference Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · July 21, 2010 The purpose of this study was to evaluate, using full-field digital mammography (FFDM), our prior computerized texture analysis method that was developed on screen-film mammography method. The evaluation included the analyses on the parenchymal patterns of ... Full text Cite

Computerized assessment of breast lesion malignancy using DCE-MRI robustness study on two independent clinical datasets from two manufacturers.

Journal Article Acad Radiol · July 2010 RATIONALE AND OBJECTIVES: To conduct a preclinical evaluation of the robustness of our computerized system for breast lesion characterization on two breast magnetic resonance imaging (MRI) databases that were acquired using scanners from two different manu ... Full text Link to item Cite

[Effect of interstitial cells of Cajal on gastrointestinal motility induced by motilin receptor agonist ABT-229].

Journal Article Zhonghua Er Ke Za Zhi · April 2010 OBJECTIVE: To investigate the effect of interstitial cells of Cajal (ICC) on contraction of intestinal tract smooth muscle induced by motilin receptor agonist. METHODS: Two kinds of smooth muscle segments were isolated from the duodenum and colon of rabbit ... Link to item Cite

Cancerous breast lesions on dynamic contrast-enhanced MR images: computerized characterization for image-based prognostic markers.

Journal Article Radiology · March 2010 PURPOSE: To assess the performance of computer-extracted dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imaging kinetic and morphologic features in the differentiation of invasive versus noninvasive breast lesions and metastatic versus no ... Full text Link to item Cite

DNA polymerase beta-dependent long patch base excision repair in living cells.

Journal Article DNA Repair (Amst) · February 4, 2010 We examined a role for DNA polymerase beta (Pol beta) in mammalian long patch base excision repair (LP BER). Although a role for Pol beta is well known in single-nucleotide BER, information on this enzyme in the context of LP BER has been limited. To exami ... Full text Link to item Cite

Effect of variable gain on computerized texture analysis on digitalized mammograms

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2010 Computerized texture analysis of mammographic images has emerged as a means to characterize breast parenchyma and estimate breast percentage density, and thus, to ultimately assess the risk of developing breast cancer. However, during the digitization proc ... Full text Cite

WE‐D‐304A‐05: Analysis of Tumor Grade Breast Carcinoma Using Computer‐Extracted Morphological and Kinetic Features in DCE‐MRI

Conference Medical Physics · January 1, 2009 Purpose: An important prognostic marker in breast cancer is the histological grade of the breast tumor. Thus, the purpose of our study is to investigate the performance of computer‐extracted morphological and kinetic features in DCE‐MRI in distinguishing b ... Full text Cite

Rapid recruitment of BRCA1 to DNA double-strand breaks is dependent on its association with Ku80.

Journal Article Mol Cell Biol · December 2008 BRCA1 is the first susceptibility gene to be linked to breast and ovarian cancers. Although mounting evidence has indicated that BRCA1 participates in DNA double-strand break (DSB) repair pathways, its precise mechanism is still unclear. Here, we analyzed ... Full text Link to item Cite

Evaluation of computer-aided diagnosis on a large clinical full-field digital mammographic dataset.

Journal Article Acad Radiol · November 2008 RATIONALE AND OBJECTIVES: To convert and optimize our previously developed computerized analysis methods for use with images from full-field digital mammography (FFDM) for breast mass classification to aid in the diagnosis of breast cancer. MATERIALS AND M ... Full text Link to item Cite

Recruitment of mismatch repair proteins to the site of DNA damage in human cells.

Journal Article J Cell Sci · October 1, 2008 Mismatch repair (MMR) proteins contribute to genome stability by excising DNA mismatches introduced by DNA polymerase. Although MMR proteins are also known to influence cellular responses to DNA damage, how MMR proteins respond to DNA damage within the cel ... Full text Link to item Cite

Performance of CADx on a large clinical database of FFDM images

Conference Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · September 9, 2008 The purpose of this study is to evaluate the performance of computer-aided diagnosis (CADx) methods for use with images from full-field digital mammography (FFDM) for breast mass lesion classification. A total of 739 FFDM images, including 287 breast mass ... Full text Cite

Identifying corresponding lesions from CC and MLO views via correlative feature analysis

Conference Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · September 9, 2008 In this study, we present a computerized framework to identify the corresponding image pair of a lesion in CC and MLO views, a prerequisite for combining information from these views to improve the diagnostic ability of both radiologists and CAD systems. A ... Full text Cite

Computerized assessment of coronary calcified plaques in CT images of a dynamic cardiac phantom

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · June 2, 2008 Motion artifacts in cardiac CT are an obstacle to obtaining diagnostically usable images. Although phase-specific reconstruction can produce images with improved assessability (image quality), this requires that the radiologist spend time and effort evalua ... Full text Cite

A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell.

Journal Article Nucleic Acids Res · May 2008 DNA double-strand breaks (DSBs) represent the most toxic DNA damage arisen from endogenous and exogenous genotoxic stresses and are known to be repaired by either homologous recombination or nonhomologous end-joining processes. Although many proteins have ... Full text Link to item Cite

SU‐HH‐AUD C‐07: Classification of Breast Carcinoma Subtypes Using Computer‐Extracted Morphological and Kinetic Features in DCE‐MRI

Conference Medical Physics · January 1, 2008 Purpose: To assess the performance of computer‐extracted morphological and kinetic features in differentiating different types of breast lesions, specifically ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC), in DCE‐MRI. Method and Mater ... Full text Cite

WE‐C‐332‐07: Comparison of Image Segmentation Methods On Classification Performance of FFDM CAD

Conference Medical Physics · January 1, 2008 Purpose: To investigate the effect of lesion segmentation on classification performance of FFDM CAD. Method and Materials: Breast lesion segmentation is an essential step in the overall image analysis for computer‐aided diagnosis. Two automatic lesion segm ... Full text Cite

Computerized assessment of motion-contaminated calcified plaques in cardiac multidetector CT.

Journal Article Med Phys · December 2007 An automated method for evaluating the image quality of calcified plaques with respect to motion artifacts in noncontrast-enhanced cardiac computed tomography (CT) images is introduced. This method involves using linear regression (LR) and artificial neura ... Full text Link to item Cite

Effect of carbenoxolone on behavior and electroencephalogram of PTZ-kindled epileptic rats

Journal Article Journal of Xi'an Jiaotong University (Medical Sciences) · December 1, 2007 Objective: To explore the effect of carbenoxolone, a gap junction blocker, on seizure and electroencephalogram (EEG) of PTZ-kindled epileptic rats. Methods: Circled digit one Of the 15 adult male Sprague-Dawley rats used in the study, 10 were intraperitone ... Cite

Progress in breast CADx

Conference 2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings · November 27, 2007 The accuracy of a medical imaging examination depends on both the quality of the image acquisition and the quality of the image interpretation. For more than half a century, computer technology greatly improved image acquisition systems, e.g., with the dev ... Full text Cite

Automatic selection of region of interest for radiographic texture analysis

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · October 18, 2007 We have been developing radiographic texture analysis (RTA) for assessing osteoporosis and the related risk of fracture. Currently, analyses are performed on heel images obtained from a digital imaging device, the GE/Lunar PIXI, that yields both the bone m ... Full text Cite

Effects of tegaserod on visceral sensitivity and expression of SP and CGRP in the rat colon

Journal Article Journal of Xi'an Jiaotong University (Medical Sciences) · October 1, 2007 Objective: To investigate the effects of tegaserod on visceral sensitivity and explore the regulating mechanism. Methods: Forty-two male Spragre-Dawley rats, which were induced colonic inflammation by intraluminal administration of trinitrobenzenesulfonic ... Cite

[Effect of carbenoxolone on expression of Fos, NMDAR2 and GFAP in the hippocampus of pentylenetetrazo-kindled epileptic rats].

Journal Article Zhongguo Dang Dai Er Ke Za Zhi · October 2007 OBJECTIVE: Gap junctions, the clusters of intercellular channels, play an important role in synchronizing electrical activity. This study investigated the effect of gap junction blocker carbenoxolone (CBX) on epileptic activity in pentylenetetrazo (PTZ)-ki ... Link to item Cite

Werner syndrome protein interacts functionally with translesion DNA polymerases.

Journal Article Proc Natl Acad Sci U S A · June 19, 2007 Werner syndrome (WS) is characterized by premature onset of age-associated disorders and predisposition to cancer. The WS protein, WRN, encodes 3' --> 5' DNA helicase and 3' --> 5' DNA exonuclease activities, and is implicated in the maintenance of genomic ... Full text Link to item Cite

Fractal analysis of mammographic parenchymal patterns in breast cancer risk assessment.

Journal Article Acad Radiol · May 2007 RATIONALE AND OBJECTIVES: To evaluate fractal-based computerized image analyses of mammographic parenchymal patterns in the task of differentiating between women at high risk and women at low risk for developing breast cancer. MATERIALS AND METHODS: The fr ... Full text Link to item Cite

A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses.

Journal Article EMBO J · April 18, 2007 DNA damage causes genome instability and cell death, but many of the cellular responses to DNA damage still remain elusive. We here report a human protein, PALF (PNK and APTX-like FHA protein), with an FHA (forkhead-associated) domain and novel zinc-finger ... Full text Link to item Cite

RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair.

Journal Article Mol Cell Biol · April 2007 The Saccharomyces cerevisiae RAD18 gene is essential for postreplication repair but is not required for homologous recombination (HR), which is the major double-strand break (DSB) repair pathway in yeast. Accordingly, yeast rad18 mutants are tolerant of ca ... Full text Link to item Cite

DNA single-strand break repair is impaired in aprataxin-related ataxia.

Journal Article Ann Neurol · February 2007 OBJECTIVE: Early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH)/ataxia with oculomotor apraxia type 1 (AOA1) is an autosomal recessive form of cerebellar ataxia. The causative protein for EAOH/AOA1, aprataxin (APTX), interacts with X-ray ... Full text Link to item Cite

Blocking the glial function suppresses subcutaneous formalin-induced nociceptive behavior in the rat.

Journal Article Neurosci Res · January 2007 This study examined whether glial cells in the trigeminal nucleus caudalis (Sp5C) were necessary for orofacial nociception and nociceptive processing induced by subcutaneously (s.c.) injection of 5% formalin into left mystacial vibrissae. The immunohistoch ... Full text Link to item Cite

Replication-dependent and -independent responses of RAD18 to DNA damage in human cells.

Journal Article J Biol Chem · November 10, 2006 Postreplication repair facilitates tolerance of DNA damage during replication, overcoming termination of replication at sites of DNA damage. A major post-replication repair pathway in mammalian cells is translesion synthesis, which is carried out by specia ... Full text Link to item Cite

Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage.

Journal Article Mol Cell · October 6, 2006 Base excision repair (BER) plays an essential role in protecting cells from mutagenic base damage caused by oxidative stress, hydrolysis, and environmental factors. POLQ is a DNA polymerase, which appears to be involved in translesion DNA synthesis (TLS) p ... Full text Link to item Cite

BLM is an early responder to DNA double-strand breaks.

Journal Article Biochem Biophys Res Commun · September 15, 2006 Bloom syndrome (BS) is an autosomal recessive disorder characterized by a marked predisposition to cancer and elevated genomic instability. The defective protein in BS, BLM, is a member of the RecQ helicase family and is believed to function in various DNA ... Full text Link to item Cite

Classification of breast lesions with multimodality computer-aided diagnosis: observer study results on an independent clinical data set.

Journal Article Radiology · August 2006 PURPOSE: To evaluate a computer-aided diagnosis multimodality intelligent workstation as an aid to radiologists in the interpretation of mammograms and breast sonograms. MATERIALS AND METHODS: An institutional review board approved the protocol for an obse ... Full text Link to item Cite

The effects of osmotic pressure changing on connexins expression in cultured rat hypothalamic astrocytes and neurons

Journal Article Acta Anatomica Sinica · August 1, 2006 Objective: To investigate the effects of osmotic pressure changing on connexin43 (Cx43) and Cx32 expression in cultured rat hypothalamic astrocytes and neurons. Methods: By culturing astrocytes and neurons fr om newborn rats, these cells were divided to tw ... Cite

GFAP and Fos immunoreactivity in lumbosacral spinal cord and medulla oblongata in rats with chronic colonic inflammation

Journal Article Acta Anatomica Sinica · June 1, 2006 Objective: To investigate the responses of astrocytes and neurons in rat lumbosacral spinal cord and medulla oblongata induced by chronic colonic inflammation, and the relationship between activated astrocytes and neurons. Methods: Thirty-three male Spragu ... Cite

Comparison of computerized image analyses for digitized screen-film mammograms and full-field digital mammography images

Conference Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · January 1, 2006 We have developed computerized methods for the analysis of mammo-graphic lesions in order to aid in the diagnosis of breast cancer. Our automatic methods include the extraction of the lesion from the breast parenchyma, the characterization of the lesion fe ... Full text Cite

The carbenoxolone reduces nociceptive behavior and exprission of Fos-like immunoreactive neurons in Sp5C of rats after subcutameous formalin injection

Journal Article Neuroscience Bulletin · December 1, 2005 Objective: To investigate the effect of carbenoxolone (CBX), a gap junction blocker, was injected into the cerebellomedullary cistern, to nociceptive behavior and the plastic response of neurons and astrocytes in spinal trigeminal nucleus caudalis (Sp5C) i ... Cite

[Effects of N-methyl-D-aspartate receptor in visceral, hypersensitivity in rats with colonic inflammation].

Journal Article Zhong Nan Da Xue Xue Bao Yi Xue Ban · October 2005 OBJECTIVE: To investigate the effects of N-methyl-D-aspartate receptor (NMDAR) in the spinal dorsal horn in visceral hypersensitivity in rats with colonic inflammation. METHODS: Seventy adult male Sprague-Dawley (SD) rats were randomly divided into the exp ... Link to item Cite

Accumulation of Werner protein at DNA double-strand breaks in human cells.

Journal Article J Cell Sci · September 15, 2005 Werner syndrome is an autosomal recessive accelerated-aging disorder caused by a defect in the WRN gene, which encodes a member of the RecQ family of DNA helicases with an exonuclease activity. In vitro experiments have suggested that WRN functions in seve ... Full text Link to item Cite

DNA polymerase lambda protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repair.

Journal Article J Biol Chem · September 9, 2005 DNA polymerase lambda (pol lambda) is a member of the X family of DNA polymerases that has been implicated in both base excision repair and non-homologous end joining through in vitro studies. However, to date, no phenotype has been associated with cells d ... Full text Link to item Cite

Computerized texture analysis of mammographic parenchymal patterns of digitized mammograms.

Journal Article Acad Radiol · July 2005 RATIONALE AND OBJECTIVES: Mammographic density and parenchymal patterns have been shown to be related to the risk of developing breast cancer. Thus, computerized texture analysis of breast parenchymal patterns on mammograms may be useful in assessing breas ... Full text Link to item Cite

MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes.

Journal Article J Exp Med · February 21, 2005 Activation-induced cytidine deaminase deaminates cytosine to uracil (dU) in DNA, which leads to mutations at C:G basepairs in immunoglobulin genes during somatic hypermutation. The mechanism that generates mutations at A:T basepairs, however, remains uncle ... Full text Link to item Cite

Translocation of XRCC1 and DNA ligase IIIalpha from centrosomes to chromosomes in response to DNA damage in mitotic human cells.

Journal Article Nucleic Acids Res · 2005 DNA single-strand breaks (SSBs) are the most frequent lesions caused by oxidative DNA damage. They disrupt DNA replication, give rise to double-strand breaks and lead to cell death and genomic instability. It has been shown that the XRCC1 protein plays a k ... Full text Link to item Cite

UV light-induced DNA damage and tolerance for the survival of nucleotide excision repair-deficient human cells.

Journal Article J Biol Chem · November 5, 2004 DNA damage can cause cell death unless it is either repaired or tolerated. The precise contributions of repair and tolerance mechanisms to cell survival have not been previously evaluated. Here we have analyzed the cell killing effect of the two major UV l ... Full text Link to item Cite

Correlation of lesions from multiple images for CAD

Conference Proceedings of SPIE - The International Society for Optical Engineering · October 27, 2004 The object of this research is to investigate a method for determining whether two different imaged presentations of a lesion actually represent the same abnormality. Tasks of this kind are expected to arise in numerous applications, including when interpr ... Full text Cite

In situ analysis of repair processes for oxidative DNA damage in mammalian cells.

Journal Article Proc Natl Acad Sci U S A · September 21, 2004 Oxidative DNA damage causes blocks and errors in transcription and replication, leading to cell death and genomic instability. Although repair mechanisms of the damage have been extensively analyzed in vitro, the actual in vivo repair processes remain larg ... Full text Link to item Cite

Computerized texture analysis of mammographic parenchymal patterns of digitized mammograms

Journal Article International Congress Series · June 1, 2004 This study involved a comparative evaluation of various computer-extracted texture features of mammographic parenchymal patterns of women with BRCA1/BRCA2 gene mutations and those of women at low risk of developing breast cancer. With our method, computeri ... Full text Cite

Computerized interpretation of breast MRI: investigation of enhancement-variance dynamics.

Conference Med Phys · May 2004 The advantages of breast MRI using contrast agent Gd-DTPA in the diagnosis of breast cancer have been well established. The variation of interpretation criteria and absence of interpretation guidelines, however, is a major obstacle for applications of MRI ... Full text Link to item Cite

Computerized analysis of mammographic parenchymal patterns for assessing breast cancer risk: effect of ROI size and location.

Journal Article Med Phys · March 2004 The long-term goal of our research is to develop computerized radiographic markers for assessing breast density and parenchymal patterns that may be used together with clinical measures for determining the risk of breast cancer and assessing the response t ... Full text Link to item Cite

Expression of Fos protein in neurons and OX42 in microglia of rat forebrain after intraperitoneal injection of lipopolysaccharide

Journal Article Chinese Journal of Neuroscience · March 1, 2004 Objective: To investigate the plastic changes of neurons and microglia and their relationship in rat forebrain after a single intraperineal (IP) injection of lipopolysaccharide (LPS). Methods: Single anti-Fos, anti-OX42 and anti-Fos/anti-tyrosine hydroxyla ... Cite

Functional and physical interactions between ERCC1 and MSH2 complexes for resistance to cis-diamminedichloroplatinum(II) in mammalian cells.

Journal Article DNA Repair (Amst) · February 3, 2004 Bulky DNA lesions are mainly repaired by nucleotide excision repair (NER), in which the interaction of ERCC1 with XPA protein recruits the ERCC1-XPF complex, which acts as a structure-specific endonuclease in the repair process. However, additional functio ... Full text Link to item Cite

Estimating three-class ideal observer decision variables for computerized detection and classification of mammographic mass lesions.

Journal Article Med Phys · January 2004 We are using Bayesian artificial neural networks (BANNs) to classify mammographic masses in schemes for computer-aided diagnosis, and we are extending this methodology to a three-class classification task. We investigated whether a BANN can estimate ideal ... Full text Link to item Cite

Computerized analysis of mammographic parenchymal patterns using fractal analysis

Conference Proceedings of SPIE - The International Society for Optical Engineering · September 15, 2003 Mammographic parenchymal patterns have been shown to be associated with breast cancer risk. Fractal-based texture analyses, including box-counting methods and Minkowski dimension, were performed within parenchymal regions of normal mammograms of BRCA1/BRCA ... Full text Cite

Comparison of approaches for risk-modulated CAD

Conference Proceedings of SPIE - The International Society for Optical Engineering · September 15, 2003 We compared computerized methods that incorporate automated lesion characterization and methods for the assessment of the breast parenchymal pattern on mammograms in order to better predict the pathological status of a breast lesion. Computer-extracted mas ... Full text Cite

Bayesian ANN estimates of three-class ideal observer decision variables for classification of mammographic masses

Conference Proceedings of SPIE - The International Society for Optical Engineering · September 12, 2003 We are using Bayesian artificial neural networks (BANNs) to classify mammographic masses. We investigated whether a BANN can estimate ideal observer decision variables to distinguish malignant, benign, and false-positive computer detections. Five features ... Full text Cite

Erratum: Spatial and temporal cellular responses to single-strand breaks in human cells (Molecular and Cellular Biology (2003) 23:11 (3974-3981))

Journal Article Molecular and Cellular Biology · August 1, 2003 Full text Cite

Spatial and temporal cellular responses to single-strand breaks in human cells.

Journal Article Mol Cell Biol · June 2003 DNA single-strand breaks (SSB) are one of the most frequent DNA lesions produced by reactive oxygen species and during DNA metabolism, but the analysis of cellular responses to SSB remains difficult due to the lack of an experimental method to produce SSB ... Full text Link to item Cite

Optimizing feature selection across a multimodality database in computerized classification of breast lesions

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2002 Linear step-wise feature selection is performed for computerized analysis methods on a set of mammography features using a database of mammography cases, a set of ultrasound features using a database of ultrasound cases, and a set of mammography and sonogr ... Full text Cite

Intelligent CAD workstation for breast imaging using similarity to known lesions and multiple visual prompt aids

Conference Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2002 While investigators have been successful in developing methods for the computerized analysis of mammograms and ultrasound images, optimal output strategies for the effective and efficient use of such computer analyses are still undetermined. We have incorp ... Full text Cite

Computer-aided diagnosis of lesions on multi-modality images of the breast

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2001 We have developed computerized methods for the analysis of lesions that combine results from different imaging modalities, in this case digitized mammograms and sonograms of the breast, for distinguishing between malignant and benign lesions. The computeri ... Full text Cite

A method for the determination of the 3D orientations and positions of catheters from single-plane x-ray images

Conference Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings · December 1, 2000 The three-dimensional (3D) orientation and position of an object, i.e., a configuration of points, can be determined by use of the single projection technique (SPT) from a single projection image, given the relative 3D positions of the points and initial e ... Cite

A system for determination of 3D vessel tree centerlines from biplane images.

Journal Article Int J Card Imaging · October 2000 With the increasing number and complexity of therapeutic coronary interventions, there is an increasing need for accurate quantitative measurements. These interventions and measurements may be facilitated by accurate and reproducible magnifications and ori ... Full text Link to item Cite

Quantitative evaluation of vessel tracking techniques on coronary angiograms.

Journal Article Med Phys · May 1999 Accurate, automated determination of vessel center lines is essential for two- and three-dimensional analysis of the coronary vascular tree. Therefore, we have been developing techniques for vessel tracking and for evaluating their accuracy and precision i ... Full text Link to item Cite

Determination of 3D vessel motion from biplane cardiac sequences

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · January 1, 1999 We have developed methods for determining 3D vessel centerlines from biplane image sequences. For dynamic quantities, e.g., vessel motion or flow, the correspondence between points along calculated centerlines must be established. We have developed and com ... Cite

Determination and evaluation of 3D biplane imaging geometries without a calibration object

Conference Proceedings of SPIE - The International Society for Optical Engineering · December 1, 1998 Quantitative vascular analysis is useful for treatment planning and evaluation of atherosclerosis, but it requires accurate and reliable determination of the 3D vascular structures from biplane images. To facilitate vascular analysis, we have developed tec ... Full text Cite

Improved coronary vessel tracking using non-linear filter enhanced X-ray angiograms

Journal Article Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings · December 1, 1997 Tracking of coronary vessel centerlines in angiograms is essential for accurate, automated quantitative vascular analysis of the coronary vessel tree. Such analyses are important for diagnosis of atherosclerosis, for surgical or treatment planning, for mon ... Cite