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Thomas James Polascik

Professor of Urology
Urology
Box 2804 Med Ctr, DUMC, Durham, NC 27710
Room D1557E Blue Zone, Duke South DUMC, Durham, NC 27710

Selected Publications


Comparison of procedural anxiety and pain associated with conventional transrectal ultrasound prostate biopsy to magnetic resonance imaging-ultrasound fusion-guided biopsy: a prospective cohort trial.

Journal Article Prostate Cancer Prostatic Dis · June 2024 BACKGROUND: Prostate cancer (PCa) diagnosis relies on biopsies, with transrectal ultrasound (TRUS) biopsies being common. Fusion biopsy (FB) offers improved diagnostic accuracy, but the pain and anxiety experienced by patients during biopsies is often over ... Full text Link to item Cite

Intratumoural immunotherapy plus focal thermal ablation for localized prostate cancer.

Journal Article Nat Rev Urol · May 2024 Major advances have been made in the use of immunotherapy for the treatment of solid tumours, including the use of intratumourally injected immunotherapy instead of systemically delivered immunotherapy. The success of immunotherapy in prostate cancer treat ... Full text Link to item Cite

Urinary fatty acid biomarkers for prostate cancer detection.

Journal Article PLoS One · 2024 The lack of accuracy in the current prostate specific antigen (PSA) test for prostate cancer (PCa) screening causes around 60-75% of unnecessary prostate biopsies. Therefore, alternative diagnostic methods that have better accuracy and can prevent over-dia ... Full text Link to item Cite

Corrigendum to “Surveillance one year post focal cryotherapy for clinically significant prostate cancer using mpMRI and PIRADS v2.1: An initial experience from a prospective phase II mandatory biopsy study” [Eur. J. Radiol. Open 11 (2023) 100529] (European Journal of Radiology Open (2023) 11, (S2352047723000552), (10.1016/j.ejro.2023.100529))

Journal Article European Journal of Radiology Open · January 1, 2024 The authors regret the amendments to name, affiliations, acknowledgment, and authorship contribution statement of Dr Melvin L.K. Chua. Dr Melvin L.K. Chua is affiliated with Department of Head and Neck and Thoracic Cancers, Division of Radiation Oncology, ... Full text Cite

Addressing racial disparities in prostate cancer pathology prediction models: external validation and comparison of four models of pathological outcome prediction before radical prostatectomy in the multiethnic SEARCH cohort

Journal Article Prostate Cancer and Prostatic Diseases · January 1, 2024 Background: Certain widely used pathological outcome prediction models that were developed in tertiary centers tend to overpredict outcomes in the community setting; thus, the Michigan Urological-Surgery Improvement Collaborative (MUSIC) model was develope ... Full text Cite

Evaluation of Recurrent Disease after Radiation Therapy for Patients Considering Local Salvage Therapy: Past vs. Contemporary Management.

Journal Article Cancers (Basel) · December 18, 2023 Recurrent prostate cancer after primary treatment with radiation therapy is a common problem. Patients with localized recurrence may benefit from salvage therapy, but careful patient selection is crucial because not all patients will benefit from local sal ... Full text Link to item Cite

Primary Whole-gland Ablation for the Treatment of Clinically Localized Prostate Cancer: A Focal Therapy Society Best Practice Statement.

Journal Article Eur Urol · December 2023 CONTEXT: Whole-gland ablation is a feasible and effective minimally invasive treatment for localized prostate cancer (PCa). Previous systematic reviews supported evidence for favorable functional outcomes, but oncological outcomes were inconclusive owing t ... Full text Link to item Cite

Surveillance one year post focal cryotherapy for clinically significant prostate cancer using mpMRI and PIRADS v2.1: An initial experience from a prospective phase II mandatory biopsy study.

Journal Article Eur J Radiol Open · December 2023 OBJECTIVES: Multiparametric magnetic resonance imaging (mpMRI) surveillance post focal cryotherapy (FT) of prostate cancer is challenging as post treatment artefacts alter mpMRI findings. In this initial experience, we assessed diagnostic performance of mp ... Full text Link to item Cite

Are higher follicle-stimulating hormone levels before androgen deprivation therapy for prostate cancer associated with oncological and cardiac outcomes and overall survival?-a population-level analysis.

Journal Article Transl Androl Urol · October 31, 2023 BACKGROUND: Androgen deprivation therapy (ADT), commonly delivered via a luteinizing hormone-releasing hormone (LHRH) agonist, is the standard treatment for advanced prostate cancer (PC). While quite effective, it has been associated with an increased risk ... Full text Link to item Cite

Salvage Cryoablation for Recurrent Prostate Cancer Following Primary External Beam Radiotherapy or Primary Cryotherapy: A Propensity Score Matched Analysis of Mid-term Oncologic and Functional Outcomes.

Journal Article Clin Genitourin Cancer · October 2023 INTRODUCTION: Local prostate cancer recurrence following radiotherapy (XRT) or cryoablation (CRYO) may be addressed with salvage cryotherapy (SCT), although little is known about how the primary treatment modality affects SCT results. Oncologic and functio ... Full text Link to item Cite

Intermediate-term oncological and functional outcomes of salvage cryotherapy for the management of prostate cancer recurrence after primary brachytherapy versus primary cryotherapy: A propensity score-matched analysis.

Journal Article Prostate · October 2023 BACKGROUND: Salvage cryotherapy (SCT) is widely used to treat prostate cancer (PCa) recurrence after radiotherapy (RT). We studied the intermediate oncological and functional outcomes of patients who underwent SCT following cryotherapy (CRYO-SCT) recurrenc ... Full text Link to item Cite

Reconciling discordance between PI-RADS 4 lesions and targeted biopsy: Early experience of a multidisciplinary quality improvement protocol with PI-RADS 4 subcategorization.

Journal Article Eur J Radiol · August 2023 PURPOSE: PI-RADS 4 lesions are considered to have a "high" likelihood of clinically-significant prostate cancer (csPCa). However, patients undergoing targeted biopsy have a range of histologic findings. Understanding discordant cases is critical to improve ... Full text Link to item Cite

Initial Longitudinal Outcomes of Risk-Stratified Men in Their Forties Screened for Prostate Cancer Following Implementation of a Baseline Prostate-Specific Antigen.

Journal Article World J Mens Health · July 2023 PURPOSE: Prostate cancer (PCa) screening can lead to potential over-diagnosis/over-treatment of indolent cancers. There is a need to optimize practices to better risk-stratify patients. We examined initial longitudinal outcomes of mid-life men with an elev ... Full text Link to item Cite

Combined ARFI and Shear Wave Imaging of Prostate Cancer: Optimizing Beam Sequences and Parameter Reconstruction Approaches.

Journal Article Ultrason Imaging · July 2023 This study demonstrates the implementation of a shear wave reconstruction algorithm that enables concurrent acoustic radiation force impulse (ARFI) imaging and shear wave elasticity imaging (SWEI) of prostate cancer and zonal anatomy. The combined ARFI/SWE ... Full text Link to item Cite

A Comprehensive Assessment of the Utility of Transperineal Template Prostate Mapping Biopsy: A 13-year Experience.

Journal Article Urology · July 2023 OBJECTIVE: To assess Duke's experience on the utility of transperineal template mapping biopsy (TTMB) for re-evaluating patients with persistently elevated prostate-specific antigen after prior negative biopsy, with pre-existing prostate cancer (PCa) alrea ... Full text Link to item Cite

Patient-reported functional outcomes and oncological control after primary focal cryotherapy for clinically significant prostate cancer: A Phase II mandatory biopsy-monitored study.

Journal Article Prostate · June 2023 INTRODUCTION: We report herein the impact of focal therapy (FT) on multi-domain functional outcomes in a Phase II prospective clinical trial (NCT04138914) in focal cryotherapy for clinically significant prostate cancer (csPCa). METHODS: The primary outcome ... Full text Link to item Cite

Oncological and Functional Outcomes for Men Undergoing Salvage Whole-gland Cryoablation for Radiation-resistant Prostate Cancer.

Journal Article European urology oncology · June 2023 BackgroundThere is no consensus on the optimal approach for salvage local therapy in radiation-resistant/recurrent prostate cancer (RRPC).ObjectiveTo investigate oncological and functional outcomes for men treated with salvage whole-gland ... Full text Cite

Clinical utility of multiple secondary combined tests in prostate cancer screening.

Journal Article Can J Urol · June 2023 INTRODUCTION: The clinical utility of concurrent Prostate Health Index (PHI) and ExosomeDx Prostate Intelliscore (EPI) testing is unclear. We sought to examine the performance of combined PHI and EPI testing on men undergoing elevated PSA work up. MATERIAL ... Link to item Cite

Comparison of procedural anxiety and pain associated with conventional transrectal ultrasound prostate biopsy to magnetic resonance imaging-ultrasound fusion-guided biopsy: a prospective cohort trial.

Journal Article Prostate Cancer Prostatic Dis · June 2024 BACKGROUND: Prostate cancer (PCa) diagnosis relies on biopsies, with transrectal ultrasound (TRUS) biopsies being common. Fusion biopsy (FB) offers improved diagnostic accuracy, but the pain and anxiety experienced by patients during biopsies is often over ... Full text Link to item Cite

Intratumoural immunotherapy plus focal thermal ablation for localized prostate cancer.

Journal Article Nat Rev Urol · May 2024 Major advances have been made in the use of immunotherapy for the treatment of solid tumours, including the use of intratumourally injected immunotherapy instead of systemically delivered immunotherapy. The success of immunotherapy in prostate cancer treat ... Full text Link to item Cite

Urinary fatty acid biomarkers for prostate cancer detection.

Journal Article PLoS One · 2024 The lack of accuracy in the current prostate specific antigen (PSA) test for prostate cancer (PCa) screening causes around 60-75% of unnecessary prostate biopsies. Therefore, alternative diagnostic methods that have better accuracy and can prevent over-dia ... Full text Link to item Cite

Corrigendum to “Surveillance one year post focal cryotherapy for clinically significant prostate cancer using mpMRI and PIRADS v2.1: An initial experience from a prospective phase II mandatory biopsy study” [Eur. J. Radiol. Open 11 (2023) 100529] (European Journal of Radiology Open (2023) 11, (S2352047723000552), (10.1016/j.ejro.2023.100529))

Journal Article European Journal of Radiology Open · January 1, 2024 The authors regret the amendments to name, affiliations, acknowledgment, and authorship contribution statement of Dr Melvin L.K. Chua. Dr Melvin L.K. Chua is affiliated with Department of Head and Neck and Thoracic Cancers, Division of Radiation Oncology, ... Full text Cite

Addressing racial disparities in prostate cancer pathology prediction models: external validation and comparison of four models of pathological outcome prediction before radical prostatectomy in the multiethnic SEARCH cohort

Journal Article Prostate Cancer and Prostatic Diseases · January 1, 2024 Background: Certain widely used pathological outcome prediction models that were developed in tertiary centers tend to overpredict outcomes in the community setting; thus, the Michigan Urological-Surgery Improvement Collaborative (MUSIC) model was develope ... Full text Cite

Evaluation of Recurrent Disease after Radiation Therapy for Patients Considering Local Salvage Therapy: Past vs. Contemporary Management.

Journal Article Cancers (Basel) · December 18, 2023 Recurrent prostate cancer after primary treatment with radiation therapy is a common problem. Patients with localized recurrence may benefit from salvage therapy, but careful patient selection is crucial because not all patients will benefit from local sal ... Full text Link to item Cite

Primary Whole-gland Ablation for the Treatment of Clinically Localized Prostate Cancer: A Focal Therapy Society Best Practice Statement.

Journal Article Eur Urol · December 2023 CONTEXT: Whole-gland ablation is a feasible and effective minimally invasive treatment for localized prostate cancer (PCa). Previous systematic reviews supported evidence for favorable functional outcomes, but oncological outcomes were inconclusive owing t ... Full text Link to item Cite

Surveillance one year post focal cryotherapy for clinically significant prostate cancer using mpMRI and PIRADS v2.1: An initial experience from a prospective phase II mandatory biopsy study.

Journal Article Eur J Radiol Open · December 2023 OBJECTIVES: Multiparametric magnetic resonance imaging (mpMRI) surveillance post focal cryotherapy (FT) of prostate cancer is challenging as post treatment artefacts alter mpMRI findings. In this initial experience, we assessed diagnostic performance of mp ... Full text Link to item Cite

Are higher follicle-stimulating hormone levels before androgen deprivation therapy for prostate cancer associated with oncological and cardiac outcomes and overall survival?-a population-level analysis.

Journal Article Transl Androl Urol · October 31, 2023 BACKGROUND: Androgen deprivation therapy (ADT), commonly delivered via a luteinizing hormone-releasing hormone (LHRH) agonist, is the standard treatment for advanced prostate cancer (PC). While quite effective, it has been associated with an increased risk ... Full text Link to item Cite

Salvage Cryoablation for Recurrent Prostate Cancer Following Primary External Beam Radiotherapy or Primary Cryotherapy: A Propensity Score Matched Analysis of Mid-term Oncologic and Functional Outcomes.

Journal Article Clin Genitourin Cancer · October 2023 INTRODUCTION: Local prostate cancer recurrence following radiotherapy (XRT) or cryoablation (CRYO) may be addressed with salvage cryotherapy (SCT), although little is known about how the primary treatment modality affects SCT results. Oncologic and functio ... Full text Link to item Cite

Intermediate-term oncological and functional outcomes of salvage cryotherapy for the management of prostate cancer recurrence after primary brachytherapy versus primary cryotherapy: A propensity score-matched analysis.

Journal Article Prostate · October 2023 BACKGROUND: Salvage cryotherapy (SCT) is widely used to treat prostate cancer (PCa) recurrence after radiotherapy (RT). We studied the intermediate oncological and functional outcomes of patients who underwent SCT following cryotherapy (CRYO-SCT) recurrenc ... Full text Link to item Cite

Reconciling discordance between PI-RADS 4 lesions and targeted biopsy: Early experience of a multidisciplinary quality improvement protocol with PI-RADS 4 subcategorization.

Journal Article Eur J Radiol · August 2023 PURPOSE: PI-RADS 4 lesions are considered to have a "high" likelihood of clinically-significant prostate cancer (csPCa). However, patients undergoing targeted biopsy have a range of histologic findings. Understanding discordant cases is critical to improve ... Full text Link to item Cite

Initial Longitudinal Outcomes of Risk-Stratified Men in Their Forties Screened for Prostate Cancer Following Implementation of a Baseline Prostate-Specific Antigen.

Journal Article World J Mens Health · July 2023 PURPOSE: Prostate cancer (PCa) screening can lead to potential over-diagnosis/over-treatment of indolent cancers. There is a need to optimize practices to better risk-stratify patients. We examined initial longitudinal outcomes of mid-life men with an elev ... Full text Link to item Cite

Combined ARFI and Shear Wave Imaging of Prostate Cancer: Optimizing Beam Sequences and Parameter Reconstruction Approaches.

Journal Article Ultrason Imaging · July 2023 This study demonstrates the implementation of a shear wave reconstruction algorithm that enables concurrent acoustic radiation force impulse (ARFI) imaging and shear wave elasticity imaging (SWEI) of prostate cancer and zonal anatomy. The combined ARFI/SWE ... Full text Link to item Cite

A Comprehensive Assessment of the Utility of Transperineal Template Prostate Mapping Biopsy: A 13-year Experience.

Journal Article Urology · July 2023 OBJECTIVE: To assess Duke's experience on the utility of transperineal template mapping biopsy (TTMB) for re-evaluating patients with persistently elevated prostate-specific antigen after prior negative biopsy, with pre-existing prostate cancer (PCa) alrea ... Full text Link to item Cite

Patient-reported functional outcomes and oncological control after primary focal cryotherapy for clinically significant prostate cancer: A Phase II mandatory biopsy-monitored study.

Journal Article Prostate · June 2023 INTRODUCTION: We report herein the impact of focal therapy (FT) on multi-domain functional outcomes in a Phase II prospective clinical trial (NCT04138914) in focal cryotherapy for clinically significant prostate cancer (csPCa). METHODS: The primary outcome ... Full text Link to item Cite

Oncological and Functional Outcomes for Men Undergoing Salvage Whole-gland Cryoablation for Radiation-resistant Prostate Cancer.

Journal Article European urology oncology · June 2023 BackgroundThere is no consensus on the optimal approach for salvage local therapy in radiation-resistant/recurrent prostate cancer (RRPC).ObjectiveTo investigate oncological and functional outcomes for men treated with salvage whole-gland ... Full text Cite

Clinical utility of multiple secondary combined tests in prostate cancer screening.

Journal Article Can J Urol · June 2023 INTRODUCTION: The clinical utility of concurrent Prostate Health Index (PHI) and ExosomeDx Prostate Intelliscore (EPI) testing is unclear. We sought to examine the performance of combined PHI and EPI testing on men undergoing elevated PSA work up. MATERIAL ... Link to item Cite

Re-thinking How We Use Prostate Health Index for African American Men.

Conference Urology · May 2023 OBJECTIVE: To assess how the validated Prostate Health Index (PHI) risk stratifications perform with African American (AA) men and establish a threshold PHI value to potentially rule out the need for prostate biopsy. MATERIALS AND METHODS: AA men meeting F ... Full text Link to item Cite

AUTHOR REPLY.

Journal Article Urology · May 2023 Full text Link to item Cite

Real-World Comparative Safety and Effectiveness of Irreversible Electroporation and High-Intensity Focused Ultrasound for Prostate Cancer Ablation.

Journal Article Urology · April 2023 OBJECTIVES: To assess the comparative safety and effectiveness of 2 prostate cancer treatment ablation modalities: irreversible electroporation (IRE) and high-intensity focused ultrasound (HIFU).  METHODS: Two systematic literature reviews (SLRs) and meta- ... Full text Link to item Cite

Is time to castration resistant prostate cancer a potential intermediate end-point for time to metastasis among men initiating androgen deprivation therapy for non-metastatic prostate cancer with rapid PSA doubling time (<9 months)?

Journal Article Prostate Cancer Prostatic Dis · March 2023 PURPOSE: Metastasis-free survival (MFS) is a surrogate for overall survival (OS) in men with non-metastatic castration-resistant prostate cancer (CRPC), but this endpoint may take years to develop in men with non-metastatic castrate-sensitive disease. The ... Full text Link to item Cite

Urological Oncology: Prostate Cancer.

Journal Article J Urol · February 2023 Full text Link to item Cite

Cryoablation for the management of Small Renal Masses

Journal Article Mini-invasive Surgery · January 1, 2023 Renal cell carcinoma is identified most often in the sixth or seventh decade of life, coinciding with the rise in incidental diagnosis of small renal masses as imaging technology has advanced. However, not all patients in this older age group are surgical ... Full text Cite

“Quality: a parallel priority to quantity in prostate cancer focal therapy”

Journal Article Prostate Cancer and Prostatic Diseases · January 1, 2023 Full text Cite

Are higher pre-diagnosis follicle stimulating hormone levels associated with long-term prostate cancer risk?

Journal Article Prostate · December 2022 BACKGROUND: Follicle stimulating hormone (FSH) is a pituitary hormone that helps regulate testosterone homeostasis. Although it is generally accepted that FSH levels increase with LHRH-agonist therapy for prostate cancer (PC), the specific impact of FSH le ... Full text Link to item Cite

Oncological and functional outcomes of men undergoing primary whole gland cryoablation of the prostate: A 20-year experience.

Journal Article Cancer · November 1, 2022 BACKGROUND: This study reports the oncological and functional outcomes in men with localized prostate cancer (Pca) who were treated with primary whole gland cryoablation (WGC) of the prostate. METHODS: The authors retrospectively reviewed their prospective ... Full text Link to item Cite

Molecular Mechanisms of Castrate-Resistant Prostate Cancer.

Journal Article Urol Clin North Am · November 2022 Despite newer therapies for castrate-resistant prostate cancer (CRPC), many patients do not experience a treatment response, and most eventually experience secondary resistance. Various androgen-receptor-related and alternative mechanisms of resistance in ... Full text Link to item Cite

Molecular biomarkers in the context of focal therapy for prostate cancer: recommendations of a Delphi Consensus from the Focal Therapy Society.

Journal Article Minerva Urol Nephrol · October 2022 BACKGROUND: Focal therapy (FT) for prostate cancer (PCa) is promising. However, long-term oncological results are awaited and there is no consensus on follow-up strategies. Molecular biomarkers (MB) may be useful in selecting, treating and following up men ... Full text Link to item Cite

Reconciling Discordance Between Prostate Biopsy Histology and Magnetic Resonance Imaging Suspicion - Implementation of a Quality Improvement Protocol of Imaging Re-review and Reverse-fusion Target Analysis.

Journal Article Eur Urol Oncol · October 2022 There is uncertainty with how to proceed when targeted prostate biopsy of suspicious multiparametric magnetic resonance imaging (mpMRI) lesions return without clinically significant prostate cancer (csPCa). While possible, there are error sources that coul ... Full text Link to item Cite

Reply by Authors.

Journal Article Urol Pract · September 2022 Full text Link to item Cite

Radium-223 Utilization Patterns and Outcomes in Clinical Practice.

Journal Article Urol Pract · September 2022 INTRODUCTION: Radium-223 was approved for metastatic castration-resistant prostate cancer based on the ALSYMPCA trial. We characterize radium-223 treatment patterns and overall survival (OS) in a large equal access health system. METHODS: We identified all ... Full text Link to item Cite

Structured approach to resolving discordance between PI-RADS v2.1 score and targeted prostate biopsy results: an opportunity for quality improvement.

Journal Article Abdom Radiol (NY) · August 2022 BACKGROUND: Prostate multiparametric magnetic resonance imaging (mpMRI) can identify lesions within the prostate with characteristics identified in Prostate Imaging Reporting and Data System (PI-RADS) v2.1 associated with clinically significant prostate ca ... Full text Link to item Cite

Device-related complications during renal cryoablation: insights from the Manufacturer and User Facility Device Experience (MAUDE) database.

Journal Article Urol Oncol · May 2022 INTRODUCTION AND OBJECTIVES: Cryoablation offers a treatment option for small renal masses ideally suited ≤3 cm. In well-selected candidates, it is associated with less perioperative morbidity compared to more invasive options, such as partial or radical n ... Full text Link to item Cite

Assessment after focal therapy: what is the latest?

Journal Article Curr Opin Urol · May 1, 2022 PURPOSE OF REVIEW: To review assessment after focal therapy (FT) in the context of developments from the past two years. RECENT FINDINGS: With a paucity of high-quality studies, recent findings are primarily reliant on results from institutional-based coho ... Full text Link to item Cite

Targeting Protein Arginine Methyltransferase 5 Suppresses Radiation-induced Neuroendocrine Differentiation and Sensitizes Prostate Cancer Cells to Radiation.

Journal Article Mol Cancer Ther · March 1, 2022 Prostate cancer remains the second leading cause of cancer death among American men. Radiotherapy is a potentially curative treatment for localized prostate cancer, and failure to control localized disease contributes to the majority of prostate cancer dea ... Full text Link to item Cite

Red Blood Cell Distribution Width Is Associated with All-cause Mortality but Not Adverse Cancer-specific Outcomes in Men with Clinically Localized Prostate Cancer Treated with Radical Prostatectomy: Findings Based on a Multicenter Shared Equal Access Regional Cancer Hospital Registry.

Journal Article Eur Urol Open Sci · March 2022 BACKGROUND: Recent reports with a small number of patients showed an association of red blood cell distribution width (RDW) with prostate cancer (PCa) progression. OBJECTIVE: To investigate whether preoperative RDW can serve as a prognostic marker in patie ... Full text Link to item Cite

Evolution of Focal Therapy in Prostate Cancer: Past, Present, and Future.

Journal Article The Urologic clinics of North America · February 2022 Organ sparing approaches for the management of localized prostate cancer were developed in part to overcome the morbidity associated with standard, whole gland treatment options. The first description of focal therapy was now over two decades ago and since ... Full text Cite

Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.

Journal Article Ann Clin Transl Neurol · February 2022 OBJECTIVE: Numerous investigators have theorized that postoperative changes in Alzheimer's disease neuropathology may underlie postoperative neurocognitive disorders. Thus, we determined the relationship between postoperative changes in cognition and cereb ... Full text Open Access Link to item Cite

Available evidence on HIFU for focal treatment of prostate cancer: a systematic review.

Journal Article Int Braz J Urol · 2022 PURPOSE: Prostate cancer (PCa) is the second most common oncologic disease among men. Radical treatment with curative intent provides good oncological results for PCa survivors, although definitive therapy is associated with significant number of serious s ... Full text Link to item Cite

HSP90-Specific nIR Probe Identifies Aggressive Prostate Cancers: Translation from Preclinical Models to a Human Phase I Study.

Journal Article Molecular cancer therapeutics · January 2022 A noninvasive test to discriminate indolent prostate cancers from lethal ones would focus treatment where necessary while reducing overtreatment. We exploited the known activity of heat shock protein 90 (Hsp90) as a chaperone critical for the function of n ... Full text Cite

Screening and Image-Guided Targeted Biopsy of Prostate Cancer Using 3D Acoustic Radiation Force Impulse (ARFI) Imaging

Conference IEEE International Ultrasonics Symposium, IUS · January 1, 2022 We have developed a 3D acoustic radiation force impulse (ARFI) imaging system that screens for prostate cancer and provides imaging guidance for a targeted biopsy in a single clinic visit. ARFI and B-mode volumes are acquired by using a rotation stage to s ... Full text Cite

Utilization of focal therapy for patients discontinuing active surveillance of prostate cancer: Recommendations of an international Delphi consensus.

Journal Article Urol Oncol · November 2021 BACKGROUND: With the advancement of imaging technology, focal therapy (FT) has been gaining acceptance for the treatment of select patients with localized prostate cancer (CaP). We aim to provide details of a formal physician consensus on the utilization o ... Full text Link to item Cite

Editorial Comment.

Journal Article J Urol · November 2021 Full text Link to item Cite

Reply by Authors.

Journal Article J Urol · November 2021 Full text Link to item Cite

Focal Cryoablation of Image-Localized Prostate Cancer.

Journal Article J Endourol · September 2021 Focal cryoablation of localized prostate cancer can offer patients superior genitourinary functional outcomes in terms of preservation of urinary continence and potency compared with radical whole-gland therapy, while maintaining intermediate-term oncologi ... Full text Link to item Cite

Oncological and Functional Outcomes of Patients Undergoing Individualized Partial Gland Cryoablation of the Prostate: A Single-Institution Experience.

Journal Article J Endourol · September 2021 Objectives: We aim at reporting the functional and oncological outcomes in men with localized prostate cancer who underwent individualized partial gland cryoablation of the prostate by using validated quality-of-life instruments. Methods: We retrospectivel ... Full text Link to item Cite

Genetically Informed Prostate Cancer Screening.

Journal Article Urol Clin North Am · August 2021 Prostate cancer represents a significant health care burden in the United States due to its incidence, treatment-related morbidity, and cancer-specific mortality. The burden begins with prostate-specific antigen screening, which has been subject to controv ... Full text Link to item Cite

Editorial Comment.

Journal Article J Urol · August 2021 Full text Link to item Cite

Prostate Cancer Detection Using 3-D Shear Wave Elasticity Imaging.

Journal Article Ultrasound Med Biol · July 2021 Transrectal ultrasound (TRUS) B-mode imaging provides insufficient sensitivity and specificity for prostate cancer (PCa) targeting when used for biopsy guidance. Shear wave elasticity imaging (SWEI) is an elasticity imaging technique that has been commerci ... Full text Link to item Cite

Deep Convolutional Neural Networks for Displacement Estimation in ARFI Imaging.

Journal Article IEEE Trans Ultrason Ferroelectr Freq Control · July 2021 Ultrasound elasticity imaging in soft tissue with acoustic radiation force requires the estimation of displacements, typically on the order of several microns, from serially acquired raw data A-lines. In this work, we implement a fully convolutional neural ... Full text Link to item Cite

Does prior surgical interventional therapy for BPH affect the oncological or functional outcomes after primary whole-gland prostate cryoablation for localized prostate cancer?

Journal Article Prostate Cancer Prostatic Dis · June 2021 BACKGROUND: To assess whether prior interventional treatment for benign prostatic hyperplasia (BPH) influences oncologic or functional outcomes following primary whole-gland prostate cryoablation. METHODS: Among 3831 men with prostate cancer who underwent ... Full text Link to item Cite

Does the type of cryoprobe affect oncological and functional outcomes in men with clinically localized prostate cancer treated with primary whole gland prostate cryoablation?

Journal Article Curr Urol · June 2021 BACKGROUND: This study aimed to compare the oncological and functional outcomes of primary whole gland cryoablation of the prostate using the variable ice cryoprobe (V-Probe®) and the conventional fixed-size ice probe. MATERIALS AND METHODS: We reviewed th ... Full text Link to item Cite

Safety of concomitant therapy with radium-223 and abiraterone or enzalutamide in a real-world population.

Journal Article Prostate · May 2021 BACKGROUND: Real-world utilization and outcomes of combination therapy for men with metastatic castrate-resistant prostate cancer (mCRPC) are largely unknown. We evaluated the overall survival (OS) and skeletal-related events (SREs) among men who received ... Full text Link to item Cite

Current state of image-guided focal therapy for prostate cancer.

Journal Article World J Urol · March 2021 PURPOSE: To review the current evidence regarding protocols and outcomes of image-guided focal therapy (FT) for prostate cancer (PCa). METHODS: A literature search of the latest published studies assessing primary FT for PCa was carried out in Medline and ... Full text Link to item Cite

Editorial Comment.

Journal Article J Urol · March 2021 Full text Link to item Cite

Implementation and Impact of a Risk-Stratified Prostate Cancer Screening Algorithm as a Clinical Decision Support Tool in a Primary Care Network.

Conference J Gen Intern Med · January 2021 BACKGROUND: Implementation methods of risk-stratified cancer screening guidance throughout a health care system remains understudied. OBJECTIVE: Conduct a preliminary analysis of the implementation of a risk-stratified prostate cancer screening algorithm i ... Full text Link to item Cite

Deep neural network for multiparametric ultrasound imaging of prostate cancer

Conference IEEE International Ultrasonics Symposium, IUS · January 1, 2021 This study presents a deep neural network (DNN) for generating a multiparametric ultrasound (mpUS) volume of the prostate by combining data from acoustic radiation force impulse (ARFI) imaging, shear wave elasticity imaging (SWEI), B-mode imaging, and quan ... Full text Cite

Veterans Affairs Prostate Cancer Treatment Sequencing (VAPCaTS): A Real-World Evidence Study of Men with Metastatic Prostate Cancer.

Journal Article Urol Pract · January 2021 INTRODUCTION: Limited real-world data are available on treatment sequences for patients with metastatic hormone-sensitive prostate cancer treated with androgen deprivation therapy plus docetaxel or abiraterone who progress to castrate resistance. METHODS: ... Full text Link to item Cite

Cryotherapy for Management of Prostate Cancer

Chapter · January 1, 2021 The aim of focal therapy for prostate cancer is targeted treatment of the clinically significant cancer foci to preserve the genitourinary function. In recent years, advances in training and safety measures have increased the clinical adoption of prostate ... Full text Cite

Multiparametric Ultrasound for Targeting Prostate Cancer: Combining ARFI, SWEI, QUS and B-Mode.

Journal Article Ultrasound Med Biol · December 2020 Diagnosing prostate cancer through standard transrectal ultrasound (TRUS)-guided biopsy is challenging because of the sensitivity and specificity limitations of B-mode imaging. We used a linear support vector machine (SVM) to combine standard TRUS imaging ... Full text Link to item Cite

Evaluating Image Quality Improvement in Multiparametric Ultrasound Imaging of Prostate Cancer by Combining ARFI, SWEI, B-mode, and QUS

Conference IEEE International Ultrasonics Symposium, IUS · September 7, 2020 This study demonstrates the application of multiparametric ultrasound (mpUS) imaging techniques for combining data from four individual modalities: acoustic radiation force impulse (ARFI) imaging, shear wave elasticity imaging (SWEI), B-mode imaging, and q ... Full text Cite

Standardized Nomenclature and Surveillance Methodologies After Focal Therapy and Partial Gland Ablation for Localized Prostate Cancer: An International Multidisciplinary Consensus.

Journal Article Eur Urol · September 2020 BACKGROUND: Focal therapy (FT) and partial gland ablation (PGA) are quickly adopted by urologists and radiologists as an option for the management of localized prostate cancer. OBJECTIVE: To find consensus on a standardized nomenclature and to define a fol ... Full text Link to item Cite

Implementation of Germline Testing for Prostate Cancer: Philadelphia Prostate Cancer Consensus Conference 2019.

Journal Article Journal of clinical oncology : official journal of the American Society of Clinical Oncology · August 2020 PurposeGermline testing (GT) is a central feature of prostate cancer (PCA) treatment, management, and hereditary cancer assessment. Critical needs include optimized multigene testing strategies that incorporate evolving genetic data, consistency i ... Full text Cite

A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.

Journal Article J Neurol · July 2020 OBJECTIVE: Lumbar punctures (LPs) are important for obtaining CSF in neurology studies but are associated with adverse events and feared by many patients. We determined adverse event rates and pain scores in patients prospectively enrolled in two cohort st ... Full text Link to item Cite

Variability of the Positive Predictive Value of PI-RADS for Prostate MRI across 26 Centers: Experience of the Society of Abdominal Radiology Prostate Cancer Disease-focused Panel.

Journal Article Radiology · July 2020 Background Prostate MRI is used widely in clinical care for guiding tissue sampling, active surveillance, and staging. The Prostate Imaging Reporting and Data System (PI-RADS) helps provide a standardized probabilistic approach for identifying clinically s ... Full text Link to item Cite

Salvage Focal Cryotherapy Offers Similar Short-term Oncologic Control and Improved Urinary Function Compared With Salvage Whole Gland Cryotherapy for Radiation-resistant or Recurrent Prostate Cancer.

Journal Article Clin Genitourin Cancer · June 2020 BACKGROUND: We compared the short-term oncologic and functional outcomes of salvage focal cryotherapy (SFC) with those of salvage total cryotherapy (STC) for radiotherapy (RT)-persistent/recurrent prostate cancer. MATERIALS AND METHODS: We queried the Cryo ... Full text Link to item Cite

Renal Thermal Ablation Trends of American Urologists.

Journal Article J Endourol · April 2020 Objective: To define current trends in the utilization of renal thermal ablation by urologists in the United States. Material and Methods: A six-month case log data for renal procedures submitted by certifying and recertifying American urologists from 2003 ... Full text Link to item Cite

Editorial Comment.

Journal Article J Urol · March 2020 Full text Link to item Cite

Racial Discrepancies in Overall Survival among Men Treated with 223Radium.

Journal Article J Urol · February 2020 PURPOSE: Several recent studies on metastatic castration resistant prostate cancer demonstrated improved overall survival in black vs white men. 223Radium is Food and Drug Administration approved for metastatic castration resistant prostate cancer based on ... Full text Link to item Cite

Retraction Note: Can the conventional sextant prostate biopsy reliably diagnose unilateral prostate cancer in low-risk, localized, prostate cancer? (Prostate Cancer and Prostatic Diseases, (2008), 10.1038/pcan.2008.31)

Journal Article Prostate Cancer and Prostatic Diseases · January 1, 2020 The authors hereby retract the e-publication dated 13 May 2008 and entitled, 'Can the conventional sextant prostate biopsy reliably diagnose unilateral prostate cancer in low-risk, localized, prostate cancer?' The authors are submitting a revised version w ... Full text Cite

The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.

Journal Article J Alzheimers Dis · 2020 BACKGROUND: Perioperative neurocognitive disorders (PND) are common complications in older adults associated with increased 1-year mortality and long-term cognitive decline. One risk factor for worsened long-term postoperative cognitive trajectory is the A ... Full text Open Access Link to item Cite

Renal Mass Biopsy: Future Trends and Developments

Chapter · January 1, 2020 Renal mass biopsy is a diagnostic technique that can be employed to evaluate the small renal mass (SRM); however, it remains underutilized to this day. The overall accuracy of percutaneous SRM biopsy is between 79% and 100%. The main shortcomings of renal ... Full text Cite

Anterior gland focal cryoablation: proof-of-concept primary prostate cancer treatment in select men with localized anterior cancers detected by multi-parametric magnetic resonance imaging.

Journal Article BMC Urol · December 5, 2019 BACKGROUND: Due to their location away from the nerve bundles, anterior prostate cancers (APC) represent a rational target for image-guided cryoablation. This report describes the feasibility and short-term outcomes of anterior focal cryosurgery. METHODS: ... Full text Link to item Cite

Editorial Comment.

Journal Article J Urol · December 2019 Full text Link to item Cite

Reply by Authors.

Journal Article J Urol · November 2019 Full text Link to item Cite

SPARED Collaboration: Patient Selection for Partial Gland Ablation in Men with Localized Prostate Cancer.

Journal Article J Urol · November 2019 PURPOSE: The SPARED CRN (Study of Prostate Ablation Related Energy Devices Coordinated Registry Network) is a private-public partnership between academic and community urologists, the FDA (U.S. Food and Drug Administration), the Medical Device Epidemiology ... Full text Link to item Cite

Focal laser ablation as clinical treatment of prostate cancer: report from a Delphi consensus project.

Journal Article World J Urol · October 2019 PURPOSE: To define the role of focal laser ablation (FLA) as clinical treatment of prostate cancer (PCa) using the Delphi consensus method. METHODS: A panel of international experts in the field of focal therapy (FT) in PCa conducted a collaborative consen ... Full text Link to item Cite

Salvage Radiotherapy for Recurrent Prostate Cancer: Can the Prognostic Grade Group System Inform Treatment Timing?

Journal Article Clin Genitourin Cancer · October 2019 PURPOSE: In order to better time salvage radiotherapy (SRT) for post-radical prostatectomy biochemical failure, we examined the association between pre-SRT prostate-specific antigen (PSA) and PSA control as a function of the new prognostic grade group (PGG ... Full text Link to item Cite

Considerations of germline testing in prostate cancer screening.

Journal Article Can J Urol · October 2019 Prostate cancer screening remains controversial in the medical field. While screening men above 50 years can impose overdiagnosis and overtreatment, targeted screening of males with pathologic variants of genetic mutations is evolving and viewed as sensibl ... Link to item Cite

Multiparametric Ultrasound for the Targeting of Prostate Cancer using ARFI, SWEI, B-mode, and QUS

Conference IEEE International Ultrasonics Symposium, IUS · October 1, 2019 Prostate cancer diagnosis using standard transrectal ultrasound (TRUS) and systematic biopsy is challenging. To improve the performance of TRUS imaging, we combined it with acoustic radiation force impulse (ARFI) imaging and shear wave elasticity imaging ( ... Full text Cite

Evaluation and Active Treatment versus Active Surveillance of Localized Prostate Cancer in Renal Transplant Patients in the Era of Low and Very Low Risk Prostate Cancer.

Journal Article J Urol · September 2019 PURPOSE: Current trends in renal transplantation, such as improved allograft/recipient survival and expanded organ transplantation eligibility criteria in older recipients, are concomitant with increasingly detected low risk prostate cancer in candidates f ... Full text Link to item Cite

Influence of African American race on the association between preoperative biopsy grade group and adverse histopathologic features of radical prostatectomy.

Journal Article Cancer · September 1, 2019 BACKGROUND: The current study was performed to evaluate the influence of race on the association between biopsy grade group (GrGp) and the risk of detectable prostate-specific antigen (PSA) and adverse histopathological outcomes after radical prostatectomy ... Full text Link to item Cite

Salvage Prostate Cryoablation for the Management of Local Recurrence After Primary Cryotherapy: A Retrospective Analysis of Functional and Intermediate-Term Oncological Outcomes Associated With a Second Therapeutic Freeze.

Journal Article Clin Genitourin Cancer · August 2019 BACKGROUND: The purpose of the study was to examine the outcomes of salvage prostate cryoablation for managing patients with local recurrence after primary cryotherapy. PATIENTS AND METHODS: The records of 108 patients treated with salvage prostate cryoabl ... Full text Link to item Cite

The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.

Journal Article J Am Geriatr Soc · April 2019 BACKGROUND/OBJECTIVES: Every year, up to 40% of the more than 16 million older Americans who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD) or delirium. Each of these distinct syndromes is associated with decreased quality of ... Full text Open Access Link to item Cite

Surveillance after prostate focal therapy.

Journal Article World J Urol · March 2019 INTRODUCTION: Long-term outcomes from large cohorts are not yet available upon which to base recommended follow-up protocols after prostate focal therapy. This is an updated summary of a 2015 SIU-ICUD review of the best available current evidence and exper ... Full text Link to item Cite

Statins are Associated With Increased Biochemical Recurrence After Radical Prostatectomy in Diabetic Men but no Association was Seen in Men also Taking Metformin: Results From the SEARCH Database.

Journal Article Clin Genitourin Cancer · February 2019 PURPOSE: To investigate the preoperative use of combination metformin and statin versus monotherapy on biochemical recurrence (BCR) after radical prostatectomy (RP) in diabetic men. PATIENTS AND METHODS: Data of 843 diabetic men who underwent RP were strat ... Full text Link to item Cite

Reduced Core Targeted (RCT) biopsy: Combining multiparametric magnetic resonance imaging - transrectal ultrasound fusion targeted biopsy with laterally-directed sextant biopsies - An alternative template for prostate fusion biopsy.

Journal Article Eur J Radiol · January 2019 PURPOSE: To introduce and assess the efficacy of a Reduced Core Targeted (RCT) biopsy template (image-targeted + laterally directed sextant biopsy) to detect clinically-significant cancer in patients with elevated PSA and a previous negative biopsy or on a ... Full text Link to item Cite

Clinicopathological characteristics of surgically treated localized renal masses in patients previously exposed to chemotherapy.

Journal Article Int Braz J Urol · 2019 PURPOSE: To explore the potential association between renal mass characteristics and a history of chemotherapy. MATERIALS AND METHODS: A retrospective review of records of patients surgically treated for a localized renal mass between 2000 and 2012 was und ... Full text Link to item Cite

Focal Therapy for Prostate Cancer: A More Vehement View of the Approach Could Translate into Real Benefits for Our Patients.

Journal Article Eur Urol · November 2018 The literature on focal therapy is currently insufficient to recommend it as first-line treatment. We need information from both randomised controlled trials and prospective registries for every available energy. That said, important research is under way ... Full text Link to item Cite

Primary care perspective and implementation of a multidisciplinary, institutional prostate cancer screening algorithm embedded in the electronic health record.

Journal Article Urol Oncol · November 2018 PURPOSE: In response to controversy regarding prostate cancer (CaP) screening recommendations, a consolidated Duke Cancer Institute (DCI) multidisciplinary algorithm for CaP screening was developed and implemented. We conducted an online survey within the ... Full text Link to item Cite

Three-dimensional localization and targeting of prostate cancer foci with imaging and histopathologic correlation: establishing a multidisciplinary team for quality improvement.

Journal Article Curr Opin Urol · November 2018 PURPOSE OF REVIEW: The current trend in image-based identification and characterization of prostate cancer (PCa) utilizing multiparametric MRI (mpMRI) has affected diagnostic and treatment planning in terms of targeted biopsy, risk stratification and progn ... Full text Link to item Cite

Focal therapy of prostate and kidney cancer.

Journal Article Curr Opin Urol · November 2018 Full text Link to item Cite

Prostate Specific Antigen Density as a Predictor of Clinically Significant Prostate Cancer When the Prostate Specific Antigen is in the Diagnostic Gray Zone: Defining the Optimum Cutoff Point Stratified by Race and Body Mass Index.

Journal Article J Urol · October 2018 PURPOSE: We assessed the predictive value of prostate specific antigen density to detect clinically significant prostate cancer, defined as prostate cancer grade group 2 or greater, in a series of men undergoing prostate biopsy with prostate specific antig ... Full text Link to item Cite

Does Any Racial Disparity Exist in Oncologic Outcomes After Primary Cryotherapy for Prostate Cancer? A Matched-pair Comparative Analysis of the Cryo On-Line Data Registry.

Journal Article Clin Genitourin Cancer · October 2018 BACKGROUND: African-American (AA) men have the greatest incidence of and disease-specific mortality from prostate cancer of any racial group. Although encouraging oncologic and functional outcomes have been reported with prostate cancer cryotherapy, little ... Full text Link to item Cite

Predictors of Rectourethral Fistula Formation After Primary Whole-Gland Cryoablation for Prostate Cancer: Results from the Cryo On-Line Database Registry.

Journal Article J Endourol · September 12, 2018 PURPOSE: To define the incidence and risk factors associated with rectourethral fistula (RUF) formation following primary whole-gland cryosurgery using a multicenter centralized registry. PATIENTS AND METHODS: The Cryo On-Line Data (COLD) registry was quer ... Full text Link to item Cite

Effect of blood transfusions on oncological outcomes of surgically treated localized renal cell carcinoma.

Journal Article Urol Oncol · August 2018 OBJECTIVE: To assess the associations between perioperative allogeneic blood transfusions (ABTs) and recurrence, overall and renal cell carcinoma (RCC)-specific survival in patients undergoing surgical treatment for clinically localized disease. MATERIALS ... Full text Link to item Cite

Multiparametric Prostate MR Imaging: Impact on Clinical Staging and Decision Making.

Journal Article Urol Clin North Am · August 2018 Meaningful changes to the approach of prostate cancer staging and management have been made over the past decade with increasing demand for high-quality multiparametric MR imaging (mpMRI) of the prostate. This article focuses on the evolving paradigm of pr ... Full text Link to item Cite

A Multi-Institutional Prospective Trial Confirms Noninvasive Blood Test Maintains Predictive Value in African American Men.

Journal Article J Urol · June 2018 PURPOSE: The 4Kscore® test accurately detects aggressive prostate cancer and reduces unnecessary biopsies. However, its performance in African American men has been unknown. We assessed test performance in a cohort of men with a large African American repr ... Full text Link to item Cite

Editorial Comment.

Journal Article J Urol · June 2018 Full text Link to item Cite

Associations Between Prostate Volume and Oncologic Outcomes in Men Undergoing Focal Cryoablation of the Prostate.

Journal Article Clin Genitourin Cancer · April 2018 INTRODUCTION: The purpose of this study was to assess the relationship of total prostate volume (TPV) and oncologic outcomes following focal prostate cryoablation. MATERIALS AND METHODS: A query of the Cryo On-Line Database (COLD) registry for men who unde ... Full text Link to item Cite

New prostate cancer prognostic grade group (PGG): Can multiparametric MRI (mpMRI) accurately separate patients with low-, intermediate-, and high-grade cancer?

Journal Article Abdom Radiol (NY) · March 2018 PURPOSE: Our objective is to determine the accuracy of multiparametric MRI (mpMRI) in predicting pathologic grade of prostate cancer (PCa) after radical prostatectomy (RP) using simple apparent diffusion coefficient metrics and, specifically, whether mpMRI ... Full text Link to item Cite

Multiparametric Prostate MR Imaging: Impact on Clinical Staging and Decision Making.

Journal Article Radiol Clin North Am · March 2018 Meaningful changes to the approach of prostate cancer staging and management have been made over the past decade with increasing demand for high-quality multiparametric MR imaging (mpMRI) of the prostate. This article focuses on the evolving paradigm of pr ... Full text Link to item Cite

Engaging the primary care community to encourage appropriate prostate cancer screening.

Journal Article Ther Adv Urol · January 2018 Prostate-specific antigen (PSA) screening for prostate cancer remains a controversial topic, particularly in the primary care community. Our multidisciplinary prostate screening panel at Duke University Health System, USA created a nuanced PSA screening al ... Full text Link to item Cite

Defeating Cancers' Adaptive Defensive Strategies Using Thermal Therapies: Examining Cancer's Therapeutic Resistance, Ablative, and Computational Modeling Strategies as a means for Improving Therapeutic Outcome.

Journal Article Technol Cancer Res Treat · January 1, 2018 BACKGROUND: Diverse thermal ablative therapies are currently in use for the treatment of cancer. Commonly applied with the intent to cure, these ablative therapies are providing promising success rates similar to and often exceeding "gold standard" approac ... Full text Link to item Cite

Prostate Shear Wave Elastography: Multiresolution Reconstruction Dependence on Push Beam Spacing

Conference IEEE International Ultrasonics Symposium, IUS · January 1, 2018 This study demonstrates the implementation of a multiresolution shear wave tracking algorithm that enables elasticity imaging of prostate cancer and zonal anatomy. The combined ARFI/SWEI sequence uses closely-spaced push beams across the lateral field of v ... Full text Cite

Correlation Between 3D ARFI and Quantitative Imaging Metrics from SWEI and Multi-Parametric MRI in Vivo in Normal and Cancerous Prostate Tissue

Conference IEEE International Ultrasonics Symposium, IUS · January 1, 2018 Prostate lesions and healthy regions from 12 radical prostatectomy patients were identified in acoustic radiation force impulse (ARFI) imaging, shear wave elasticity imaging (SWEI), and multi-parametric magnetic resonance imaging (mpMRI) apparent diffusion ... Full text Cite

Validation of the 2015 prostate cancer grade groups for predicting long-term oncologic outcomes in a shared equal-access health system.

Journal Article Cancer · November 1, 2017 BACKGROUND: A 5-tier prognostic grade group (GG) system was enacted to simplify the risk stratification of patients with prostate cancer in which Gleason scores of ≤6, 3 + 4, 4 + 3, 8, and 9 or 10 are considered GG 1 through 5, respectively. The authors in ... Full text Link to item Cite

Patient selection for prostate focal therapy in the era of active surveillance: an International Delphi Consensus Project.

Journal Article Prostate Cancer Prostatic Dis · September 2017 BACKGROUND: Whole-gland extirpation or irradiation is considered the gold standard for curative oncological treatment for localized prostate cancer, but is often associated with sexual and urinary impairment that adversely affects quality of life. This has ... Full text Link to item Cite

Does mpMRI improve clinical criteria in selecting men with prostate cancer for active surveillance?

Journal Article Prostate Cancer Prostatic Dis · September 2017 BACKGROUND: Active surveillance (AS) has excellent short to medium term outcomes in well-selected prostate cancer patients. Traditional biopsy-based selection criteria have been criticized for inaccurate determination of cancer grade and extent. We evaluat ... Full text Link to item Cite

New advances in focal therapy for early stage prostate cancer.

Journal Article Expert Rev Anticancer Ther · August 2017 Prostate focal therapy offers men the opportunity to achieve oncological control while preserving sexual and urinary function. The prerequisites for successful focal therapy are to accurately identify, localize and completely ablate the clinically signific ... Full text Link to item Cite

Body mass index and the clinicopathological characteristics of clinically localized renal masses-An international retrospective review.

Journal Article Urol Oncol · July 2017 OBJECTIVES: To investigate the potential association between body mass index (BMI) and clinicopathological features of clinically localized renal masses. MATERIALS AND METHODS: An international, multi-institutional retrospective review of patients who unde ... Full text Link to item Cite

The Contemporary Role of Multiparametric Magnetic Resonance Imaging in Active Surveillance for Prostate Cancer.

Journal Article Curr Urol Rep · July 2017 PURPOSE OF REVIEW: Growing research supports the use of multiparametric magnetic resonance imaging (mpMRI) for the evaluation of localized prostate cancer (PCa). We highlight contemporary evidence supporting its use in active surveillance (AS). RECENT FIND ... Full text Link to item Cite

Propensity Score-Matched Comparison of Partial to Whole-Gland Cryotherapy for Intermediate-Risk Prostate Cancer: An Analysis of the Cryo On-Line Data Registry Data.

Journal Article J Endourol · June 2017 OBJECTIVE: To compare the oncologic and functional outcomes of partial vs whole-gland cryotherapy for men with intermediate-risk prostate cancer. SUBJECTS/PATIENTS: Men with intermediate-risk prostate cancer treated with primary prostate cryotherapy from 1 ... Full text Link to item Cite

Utilization of multiparametric prostate magnetic resonance imaging in clinical practice and focal therapy: report from a Delphi consensus project.

Journal Article World J Urol · May 2017 PURPOSE: To codify the use of multiparametric magnetic resonance imaging (mpMRI) for the interrogation of prostate neoplasia (PCa) in clinical practice and focal therapy (FT). METHODS: An international collaborative consensus project was undertaken using t ... Full text Link to item Cite

Prostate Specific Antigen Nadir of 0.1 or Less Is a Predictor of Treatment Success in Men Undergoing Salvage Whole Prostate Gland Cryoablation.

Journal Article J Endourol · May 2017 PURPOSE: To assess factors that affect prostate biopsy results following salvage whole gland cryoablation. PATIENTS AND METHODS: One hundred seventy-four patients underwent prostate biopsy following salvage whole gland cryoablation of the prostate in the C ... Full text Link to item Cite

High-intensity focused ultrasound for focal therapy: reality or pitfall?

Journal Article Curr Opin Urol · March 2017 PURPOSE OF REVIEW: Progress in imaging, fusion software, and ablative modalities has fostered growth of the latest image-guided generation of high-intensity focused ultrasound (HIFU) for focal treatment of prostate cancer. Although early reports are encour ... Full text Link to item Cite

Assessing clinically significant prostate cancer: Diagnostic properties of multiparametric magnetic resonance imaging compared to three-dimensional transperineal template mapping histopathology.

Journal Article Int J Urol · February 2017 OBJECTIVE: To evaluate the diagnostic properties of multiparametric magnetic resonance imaging in the detection, localization and characterization of prostate cancer using three-dimensional transperineal template mapping biopsy histopathology as the compar ... Full text Link to item Cite

New and Established Technology in Focal Ablation of the Prostate: A Systematic Review.

Journal Article Eur Urol · January 2017 CONTEXT: Focal therapy of prostate cancer has been proposed as an alternative to whole-gland treatments. OBJECTIVE: To summarize the evidence regarding sources of energy employed in focal therapy. EVIDENCE ACQUISITION: Embase and Medline (PubMed) were sear ... Full text Link to item Cite

Prostate cryotherapy

Chapter · January 1, 2017 Cryotherapy is a recognized treatment option for prostate cancer both in the primary and salvage settings. Herein, we summarize the current knowledge on cryotherapy for prostate cancer including elements of cryobiology, complications, oncological, and func ... Full text Cite

Integration of multiparametric MRI into active surveillance of prostate cancer.

Journal Article Future Oncol · November 2016 Prostate cancer is the most common noncutaneous cancer in men though many men will not die of this disease and may not require definitive treatment. Active surveillance (AS) is an increasingly utilized potential solution to the issue of overtreatment of pr ... Full text Link to item Cite

Comparison between 3D ARFI imaging and mpMRI in detecting clinically-significant prostate cancer lesions

Conference IEEE International Ultrasonics Symposium, IUS · November 1, 2016 Current prostate cancer screening methods involve non-targeted needle biopsies and detection of clinically-insignificant lesions that receive excessive treatments, exposing patients to unnecessary adverse side effects and placing a burden on our health car ... Full text Cite

Standardization of definitions in focal therapy of prostate cancer: report from a Delphi consensus project.

Journal Article World J Urol · October 2016 PURPOSE: To reach standardized terminology in focal therapy (FT) for prostate cancer (PCa). METHODS: A four-stage modified Delphi consensus project was undertaken among a panel of international experts in the field of FT for PCa. Data on terminology in FT ... Full text Link to item Cite

Targeted Anterior Gland Focal Therapy-a Novel Treatment Option for a Better Defined Disease.

Journal Article Current urology reports · October 2016 The goal of focal therapy is to achieve long-term oncological control by eradicating only the clinically significant focus/foci of cancer within the prostate, while preserving erectile function and continence. Anterior prostate cancers may have a PZ or TZ ... Full text Cite

Editorial Comment.

Other J Urol · September 2016 Full text Link to item Cite

Defining the Incremental Utility of Prostate Multiparametric Magnetic Resonance Imaging at Standard and Specialized Read in Predicting Extracapsular Extension of Prostate Cancer.

Journal Article Eur Urol · August 2016 UNLABELLED: Multiparametric magnetic resonance imaging (mpMRI) is increasingly used in staging early prostate cancer (PCa) but remains heavily reader-dependent. We aim to define the incremental utility of mpMRI over clinical parameters in determining the p ... Full text Link to item Cite

Effect of positive end-expiratory pressure on blood loss during retropubic and robot-assisted laparoscopic radical prostatectomy.

Journal Article Int J Urol · August 2016 OBJECTIVES: To study the effect of end-expiratory pressure used during anesthesia on blood loss during radical prostatectomy. METHODS: We evaluated 247 patients who underwent either radical retropubic prostatectomy or robot-assisted laparoscopic prostatect ... Full text Link to item Cite

Can Radiologic Staging With Multiparametric MRI Enhance the Accuracy of the Partin Tables in Predicting Organ-Confined Prostate Cancer?

Journal Article AJR Am J Roentgenol · July 2016 OBJECTIVE: The purpose of this study is to investigate the accuracy of multiparametric MRI with endorectal coil and Partin tables in predicting organ-confined (OC) prostate cancer in a contemporary cohort undergoing radical prostatectomy (RP) and to assess ... Full text Link to item Cite

Focal Cryotherapy for Localized Prostate Cancer.

Journal Article Arch Esp Urol · July 2016 OBJECTIVE: To systematically review the oncological and functional outcomes of contemporary primary prostate focal cryotherapy for localized prostate cancer in the context of current developments in prostate focal therapy. METHODS: We performed a systemati ... Link to item Cite

Five-Year Biochemical Progression-Free Survival Following Salvage Whole-Gland Prostate Cryoablation: Defining Success with Nadir Prostate-Specific Antigen.

Journal Article J Endourol · June 2016 BACKGROUND AND OBJECTIVES: Salvage prostate cryoablation is an effective treatment for patients with localized prostate cancer relapse following primary radiotherapy. The postsalvage prostate-specific antigen (PSA) nadir that best predicts long-term bioche ... Full text Link to item Cite

Identifying Clinically Significant Prostate Cancers using 3-D In Vivo Acoustic Radiation Force Impulse Imaging with Whole-Mount Histology Validation.

Journal Article Ultrasound Med Biol · June 2016 Overly aggressive prostate cancer (PCa) treatment adversely affects patients and places an unnecessary burden on our health care system. The inability to identify and grade clinically significant PCa lesions is a factor contributing to excessively aggressi ... Full text Link to item Cite

Cryoablation for Small Renal Masses: Selection Criteria, Complications, and Functional and Oncologic Results.

Journal Article Eur Urol · January 2016 CONTEXT: Cryoablation (CA) is a minimally invasive modality with low complication rates, but its use in urology is relatively recent. OBJECTIVE: To summarize available evidence for CA for small renal masses (SRMs) and to assess the selection criteria, comp ... Full text Link to item Cite

Primary Cryotherapy for High-Grade Clinically Localized Prostate Cancer: Oncologic and Functional Outcomes from the COLD Registry.

Journal Article J Endourol · January 2016 OBJECTIVE: To evaluate the oncological and functional outcomes of primary cryotherapy in men with clinically localized, high-grade prostate cancer. SUBJECTS AND METHODS: We included all men with biopsy Gleason score ≥8, localized (cT1-2) disease with a ser ... Full text Link to item Cite

Navigating MRI-TRUS fusion biopsy: optimizing the process and avoiding technical pitfalls.

Journal Article Expert Rev Anticancer Ther · 2016 Multi-parametric MRI (mpMRI) is widely used in the detection and characterization of clinically- significant prostate cancer. MRI-TRUS (trans-rectal ultrasound) fusion biopsy is an in-office procedure that promises to empower urologists to successfully tar ... Full text Link to item Cite

Comparison of Outcomes Between Preoperatively Potent Men Treated with Focal Versus Whole Gland Cryotherapy in a Matched Population.

Journal Article J Endourol · October 2015 BACKGROUND AND PURPOSE: The refinement in the localization of prostate cancer tumor foci through transperineal template-mapping biopsies and MRI has led to an increased interest in lesion-directed focal prostatic cryoablation. Data are lacking, however, th ... Full text Link to item Cite

Follow-up modalities in focal therapy for prostate cancer: results from a Delphi consensus project.

Journal Article World J Urol · October 2015 INTRODUCTION: Focal therapy can offer the middle ground for treatment between active surveillance and radical therapy in patients with low- and intermediate-risk prostate cancer. Factors that prohibit focal therapy from being standard of care are numerous. ... Full text Link to item Cite

A pretreatment nomogram for prediction of biochemical failure after primary cryoablation of the prostate.

Journal Article Prostate · September 2015 BACKGROUND: To create a predictive nomogram for biochemical failure following primary whole-gland cryoablation of the prostate for localized prostate cancer (LPCa). METHODS: We retrospectively analyzed 2,242 patients from the Cryo On-Line Database (COLD) w ... Full text Link to item Cite

Apparent Diffusion Coefficient Values of the Benign Central Zone of the Prostate: Comparison With Low- and High-Grade Prostate Cancer.

Journal Article AJR Am J Roentgenol · August 2015 OBJECTIVE: The apparent diffusion coefficient (ADC) values for benign central zone (CZ) of the prostate were compared with ADC values of benign peripheral zone (PZ), benign transition zone (TZ), and prostate cancer, using histopathologic findings from radi ... Full text Link to item Cite

Re-purposing cryoablation: a combinatorial 'therapy' for the destruction of tissue.

Journal Article Prostate Cancer Prostatic Dis · June 2015 It is now recognized that the tumor microenvironment creates a protective neo-tissue that isolates the tumor from the various defense strategies of the body. Evidence demonstrates that, with successive therapeutic attempts, cancer cells acquire resistance ... Full text Link to item Cite

Current trends and new frontiers in focal therapy for localized prostate cancer.

Journal Article Curr Urol Rep · June 2015 Prostate cancer (PCa) care is an ever-evolving field. Research and technological developments continue to refine our definitions and management of this disease. Now, with a greater understanding of the natural history of PCa, the prevention of overtreatmen ... Full text Link to item Cite

Active surveillance for prostate cancer: can we modernize contemporary protocols to improve patient selection and outcomes in the focal therapy era?

Journal Article Curr Opin Urol · May 2015 PURPOSE OF REVIEW: In the absence of whole gland treatment for prostate cancer, both active surveillance and focal therapy share the common need of requiring a more thorough, detailed and precise analysis of the biological threats within the prostatic pare ... Full text Link to item Cite

Focal therapy: patients, interventions, and outcomes--a report from a consensus meeting.

Journal Article Eur Urol · April 2015 BACKGROUND: Focal therapy as a treatment option for localized prostate cancer (PCa) is an increasingly popular and rapidly evolving field. OBJECTIVE: To gather expert opinion on patient selection, interventions, and meaningful outcome measures for focal th ... Full text Link to item Cite

Disparate results between proliferation rates of surgically excised prostate tumors and an in vitro bioassay using sera from a positive randomized controlled trial.

Journal Article Biotech Histochem · April 2015 In vitro bioassay has been used extensively to test the effects of culturing cancer cells in sera from humans participating in dietary interventions, i.e, studies of modified intake of nutrients for the purpose of reducing cancer risk or progression. It ha ... Full text Link to item Cite

Detection of prostate cancer with multiparametric MRI (mpMRI): effect of dedicated reader education on accuracy and confidence of index and anterior cancer diagnosis.

Journal Article Abdom Imaging · January 2015 PURPOSE: To evaluate the impact of dedicated reader education on accuracy/confidence of peripheral zone index cancer and anterior prostate cancer (PCa) diagnosis with mpMRI; secondary aim was to assess the ability of readers to differentiate low-grade canc ... Full text Link to item Cite

B-mode and acoustic radiation force impulse (ARFI) imaging of prostate zonal anatomy: comparison with 3T T2-weighted MR imaging.

Journal Article Ultrason Imaging · January 2015 Prostate cancer (PCa) is the most common non-cutaneous malignancy among men in the United States and the second leading cause of cancer-related death. Multi-parametric magnetic resonance imaging (mpMRI) has gained recent popularity to characterize PCa. Aco ... Full text Link to item Cite

Prostate elastography

Chapter · January 1, 2015 Conventional B-mode transrectal ultrasound (TRUS) generates images of the acoustic properties of tissues (density and sound speed). TRUS is used extensively to aid in visualizing the prostate gland and needle during biopsy. However, TRUS has limited sensit ... Full text Cite

Definitions and principles of focal therapy

Chapter · January 1, 2015 Focal therapy is a treatment concept that is quite broad in clinical application, encompassing the spectrum of precise laser ablation of a tumor target to near complete destruction of a large portion of thegland, as long as sexual and urinary function can ... Full text Cite

Modernizing the diagnostic and decision-making pathway for prostate cancer.

Journal Article Clin Cancer Res · December 15, 2014 PSA has led to a drastic increase in the detection of prostate cancer, rendering this biomarker the gateway for the diagnostic pathway of prostatic neoplasms. However, the increase in incidence has not been mirrored by a similar reduction in mortality. Wid ... Full text Link to item Cite

Recent Developments in Multiparametric Prostate MR Imaging

Journal Article Current Radiology Reports · December 14, 2014 Multiparametric magnetic resonance imaging (mpMRI) of the prostate has become a mature and accepted technology in the evaluation of the patient with suspected prostate cancer (PCa). This review focuses on key recent developments in the area of mpMRI, speci ... Full text Cite

3D in vivo ARFI imaging: Prostate cancer sensitivity

Conference IEEE International Ultrasonics Symposium, IUS · October 20, 2014 Imaging tools that reliably visualize prostate cancer (PCa) are increasingly needed in the urological community. The objective of this research was to evaluate the ability of Acoustic Radiation Force Impulse (ARFI) imaging to localize PCa in 29 patients wi ... Full text Cite

Psychosocial trajectories of men monitoring prostate-specific antigen levels following surgery for prostate cancer.

Journal Article Oncol Nurs Forum · July 1, 2014 PURPOSE/OBJECTIVES: To describe the psychosocial trajectories of men treated surgically for prostate cancer after monitoring their prostate-specific antigen (PSA) levels until 24 months post-treatment. DESIGN: Descriptive longitudinal study. SETTING: Urolo ... Full text Link to item Cite

Low central venous pressure versus acute normovolemic hemodilution versus conventional fluid management for reducing blood loss in radical retropubic prostatectomy: a randomized controlled trial.

Journal Article Curr Med Res Opin · May 2014 OBJECTIVE: To compare acute normovolemic hemodilution versus low central venous pressure strategy versus conventional fluid management in reducing intraoperative estimated blood loss, hematocrit drop and need for blood transfusion in patients undergoing ra ... Full text Link to item Cite

Survival of patients undergoing cytoreductive surgery for metastatic renal cell carcinoma in the targeted-therapy era.

Journal Article Anticancer Res · May 2014 BACKGROUND/AIM: In the cytokine era, cytoreductive nephrectomy (CN) improves survival for patients with metastatic renal cell carcinoma (mRCC). We analyzed the effect of CN on the survival of patients diagnosed with mRCC in the era of tyrosine kinase inhib ... Link to item Cite

Bayesian shear wave speed estimation for in vivo 3D imaging of the prostate

Conference IEEE International Ultrasonics Symposium, IUS · December 1, 2013 Shear wave elasticity imaging (SWEI) has shown promise for visualizing structure and pathology within multiple organs; however, due to the assumptions of time of flight algorithms, artifacts caused by reflected waves at structural boundaries may be present ... Full text Cite

Radiation exposure associated with dedicated renal mass computed tomography protocol: impact of patient characteristics.

Journal Article J Endourol · September 2013 BACKGROUND AND PURPOSE: Renal mass protocol CT (RMP-CT) using multiphase abdomen and pelvis CT imaging is the mainstay for diagnosis, characterization, and follow-up for renal masses; however, it is associated with ionizing radiation to the patient. We sou ... Full text Link to item Cite

Bilateral focal ablation of prostate tissue using low-energy direct current (LEDC): a preclinical canine study.

Journal Article BJU Int · August 2013 OBJECTIVE: To evaluate side-effects, erectile function and capability to preserve adjacent tissues of bilateral focal prostate ablation using low-energy direct current (LEDC) in a canine model. MATERIALS AND METHODS: In all, 12 male Beagle dogs underwent b ... Full text Link to item Cite

Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer.

Journal Article J Med Food · April 2013 Enterolactone and enterodiol, mammalian lignans derived from dietary sources such as flaxseed, sesame seeds, kale, broccoli, and apricots, may impede tumor proliferation by inhibiting activation of nuclear factor kappa B (NFκB) and vascular endothelial gro ... Full text Link to item Cite

The state of prostate MRI in 2013.

Journal Article Oncology (Williston Park) · April 2013 Compared with earlier prostate MRI techniques that suffered from relatively poor sensitivity and specificity for detecting prostate cancer because of their reliance predominantly on morphology, multiparametric prostate MRI (mpMRI) in 2013 provides a wealth ... Link to item Cite

Preoperative predictors of pathologic stage T2a and pathologic Gleason score ≤ 6 in men with clinical low-risk prostate cancer treated with radical prostatectomy: reference for active surveillance.

Journal Article Med Oncol · March 2013 To assess preoperative parameters that may be predictive of pathologic stage T2a (pT2a) and pathologic Gleason score (pGS) ≤ 6 disease in low-risk prostate cancer patients considering active surveillance. A cohort of 1,495 men with low-risk prostate cancer ... Full text Link to item Cite

Sexual bother and function after radical prostatectomy: predictors of sexual bother recovery in men despite persistent post-operative sexual dysfunction.

Journal Article Andrology · March 2013 Changes in sexual bother (SB) following radical prostatectomy (RP) negatively affect health-related quality of life (HRQoL) of prostate cancer survivors. However, post-operative SB tends to be neglected whereas sexual function (SF) is thoroughly assessed i ... Full text Link to item Cite

Preface

Book · January 1, 2013 Full text Cite

Roadmap for focal therapy

Chapter · January 1, 2013 Full text Cite

Evolution of the concept of focal therapy for prostate cancer.

Journal Article Oncology (Williston Park) · January 2013 The landscape of prostate cancer has been rapidly evolving, and technological advances in imaging and biopsy tools offer novel approaches to focal therapy. In this dynamic environment, the role of focal therapy for prostate cancer is being shaped both by a ... Link to item Cite

Evolution of the concept of focal therapy for prostate cancer.

Journal Article Oncology (Williston Park, N.Y.) · January 1, 2013 The landscape of prostate cancer has been rapidly evolving, and technological advances in imaging and biopsy tools offer novel approaches to focal therapy. In this dynamic environment, the role of focal therapy for prostate cancer is being shaped both by a ... Cite

Comparison of concurrently acquired in vivo 3D ARFI and SWEI images of the prostate

Conference IEEE International Ultrasonics Symposium, IUS · December 1, 2012 In the prostate, ARFI and SWEI imaging methods have reported that cancer and other pathologies as being stiffer than the surrounding tissue. A three-dimensional in vivo prostatic imaging system capable of concurrently acquiring ARFI and SWEI data was devel ... Full text Cite

Mn porphyrins as novel molecular magnetic resonance imaging contrast agents.

Journal Article J Endourol · November 2012 BACKGROUND AND PURPOSE: In this study, we investigated the potential of a new class of therapeutic Mn porphyrins as molecular MRI probes for prostate cancer imaging. Two compounds of different bioavailibility were investigated: Mn(III) meso-tetrakis(N-ethy ... Full text Link to item Cite

Clinical, pathologic, and functional outcomes after nephron-sparing surgery in patients with a solitary kidney: a multicenter experience.

Journal Article J Endourol · October 2012 BACKGROUND AND PURPOSE: Surgical management of a renal neoplasm in a solitary kidney is a balance between oncologic control and preservation of renal function. We analyzed patients with a renal mass in a solitary kidney undergoing nephron-sparing procedure ... Full text Link to item Cite

Role of transrectal ultrasonography (TRUS) in focal therapy of prostate cancer: report from a Consensus Panel.

Journal Article BJU Int · October 2012 What's known on the subject? and What does the study add? Focal therapy techniques are emerging in prostate cancer treatment. However, several key questions about patient selection, treatment and monitoring still have to be addressed. The concept of focal ... Full text Link to item Cite

Rationale for percutaneous biopsy and histologic characterisation of renal tumours.

Journal Article Eur Urol · September 2012 CONTEXT: The use of percutaneous biopsy of renal tumours has been traditionally reserved for selected cases because of uncertainties regarding its safety, accuracy, and clinical utility. With the adoption of modern biopsy techniques and increasing expertis ... Full text Link to item Cite

Characteristics and outcomes of tumors arising from the distal nephron.

Journal Article Urology · July 2012 OBJECTIVE: To compare the characteristics and predictors of cancer-specific survival (CSS) of 2 rare distal nephron tumors--medullary renal cell carcinoma (MRCC) and collecting duct carcinoma (CDC). METHODS: All cases of histologically verified MRCC and CD ... Full text Link to item Cite

Transatlantic Consensus Group on active surveillance and focal therapy for prostate cancer.

Journal Article BJU Int · June 2012 Featured Publication UNLABELLED: What's known on the subject? and What does the study add? Active surveillance for prostate cancer is gaining increasing acceptance for low risk prostate cancer. Focal therapy is an emerging tissue preservation strategy that aims for treat only ... Full text Link to item Cite

Role of oxidative stress in a rat model of radiation-induced erectile dysfunction.

Journal Article J Sex Med · June 2012 INTRODUCTION: Chronic oxidative stress is one of the major factors playing an important role in radiation-induced normal tissue injury. However, the role of oxidative stress in radiation-induced erectile dysfunction (ED) has not been fully investigated. Ai ... Full text Link to item Cite

Contrast enhancement on computed tomography after renal cryoablation: an evidence of treatment failure?

Journal Article J Endourol · April 2012 Featured Publication BACKGROUND AND PURPOSE: Renal cryoablation has gained popularity as a treatment option for localized renal masses. Treatment success is typically defined by the absence of contrast enhancement on follow-up imaging. We investigate the evolution of lesions t ... Full text Link to item Cite

Focal therapy of prostate cancer: evidence-based analysis for modern selection criteria.

Journal Article Curr Urol Rep · April 2012 Featured Publication Focal therapy for prostate cancer has been increasingly utilized with the goal of effective disease control while maximizing patient functional outcomes. The optimal patient selection criteria are not known and therefore are not standardized. This review c ... Full text Link to item Cite

Association between preoperative erectile dysfunction and prostate cancer features--an analysis from the Duke Prostate Center Database.

Journal Article J Sex Med · April 2012 Featured Publication INTRODUCTION: Erectile dysfunction (ED) is related to several co-morbidities including obesity, metabolic syndrome, cigarette smoking, and low testosterone, all of which have been reported to be associated with adverse prostate cancer features. AIM: To exa ... Full text Link to item Cite

The number of high-risk factors and the risk of prostate cancer-specific mortality after brachytherapy: implications for treatment selection.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2012 Featured Publication PURPOSE: To determine whether an increasing number of high-risk factors is associated with higher prostate cancer-specific mortality (PCSM) among men treated with brachytherapy (BT)-based treatment, and whether supplemental therapy has an impact on this ri ... Full text Link to item Cite

Complications and postoperative events after cryosurgery for prostate cancer.

Journal Article BJU Int · March 2012 Featured Publication OBJECTIVES: There has been a call in the urological literature for standardized reporting of complications. To use strict criteria aiming to report our complications and other postoperative events in a cohort of men undergoing third-generation prostate cry ... Full text Link to item Cite

Vitamin D(3) cryosensitization increases prostate cancer susceptibility to cryoablation via mitochondrial-mediated apoptosis and necrosis.

Journal Article BJU Int · March 2012 Featured Publication OBJECTIVES: To investigate the effect and molecular mechanisms of action of Vitamin D(3) (VD(3) ) as a neo-adjunctive agent before cryosurgery in an effort to increase treatment efficacy for prostate cancer (CaP). To eliminate the potential for disease rec ... Full text Link to item Cite

Cryotherapy of the Prostate

Chapter · January 5, 2012 Cryosurgery represents a recognized option for the treatment of prostate cancer. Herein we discuss the principles of cryobiology and their implications in modern cryosurgery, review the indications for primary and salvage cryotherapy, as well as summarize ... Full text Cite

Cryotherapy

Chapter · January 1, 2012 Cryotherapy is a recognized treatment option for prostate cancer both in the primary and salvage settings. Herein, we summarize the current knowledge on cryotherapy for prostate cancer including elements of cryobiology, complications, and oncological outco ... Full text Cite

Predicting biopsy-proven prostate cancer recurrence following cryosurgery.

Journal Article Urol Oncol · 2012 Featured Publication OBJECTIVES: Prostate cancer (CaP) cryosurgery utilizes PSA nadir level and radiotherapy criteria as surrogates for success. We attempted to correlate PSA doubling time (PSAdt) and time of undetectable PSA (TUPSA) with biopsy-proven cancer recurrence (BPR) ... Full text Link to item Cite

Biopsy accuracy in identifying unilateral prostate cancer depends on prostate weight.

Journal Article Urol Oncol · 2012 Featured Publication OBJECTIVE: To evaluate the association between prostate weight and the diagnostic performance of routine biopsy schemes in detecting unilateral prostate cancer (PCa) that may be amenable to focal therapy. METHODS AND MATERIALS: Retrospective analysis of pa ... Full text Link to item Cite

111-In-capromab pendetide imaging using hybrid-γ camera-computer tomography technology is not reliable in detecting seminal vesicle invasion in patients with prostate cancer.

Journal Article Urol Oncol · 2012 Featured Publication OBJECTIVES: In this study, we evaluate the diagnostic utility of a hybrid γ-camera-computer tomography (SPECT-CT) indium-111 (111-In)-capromab pendetide scan in detecting seminal vesicle invasion (SVI) in select patients evaluated for primary surgical trea ... Full text Link to item Cite

Acoustic radiation force impulse imaging of human prostates: initial in vivo demonstration.

Journal Article Ultrasound Med Biol · January 2012 Featured Publication Reliably detecting prostate cancer (PCa) has been a challenge for current imaging modalities. Acoustic radiation force impulse (ARFI) imaging is an elasticity imaging method that uses remotely generated, focused acoustic beams to probe tissue stiffness. A ... Full text Link to item Cite

The effect of noise-cancelling headphones or music on pain perception and anxiety in men undergoing transrectal prostate biopsy.

Journal Article Urology · January 2012 Featured Publication OBJECTIVE: To assess the effect of noise-cancelling headphones with or without music on patient pain and anxiety associated with routine, office-based transrectal ultrasound (TRUS)-guided prostate biopsy in a prospective randomized study. METHODS: Patients ... Full text Link to item Cite

Utilization trends at a multidisciplinary prostate cancer clinic: initial 5-year experience from the Duke Prostate Center.

Journal Article J Urol · January 2012 Featured Publication PURPOSE: The multidisciplinary approach is becoming increasingly encouraged but little is known about the multidisciplinary experience compared to routine care. For patients with prostate cancer the goal is to provide evaluations by urologists, medical and ... Full text Link to item Cite

Preoperative predictors of pathologic stage T2a in low-risk prostate cancer: implications for focal therapy.

Journal Article Urol Int · 2012 OBJECTIVE: To assess preoperative parameters that may be predictive of pathologic stage T2a disease in low-risk prostate cancer patients. METHODS: Data from a cohort of 1,495 consecutive men with low-risk prostate cancer who underwent a radical prostatecto ... Full text Link to item Cite

Prostatic alpha-linolenic acid (ALA) is positively associated with aggressive prostate cancer: a relationship which may depend on genetic variation in ALA metabolism.

Journal Article PLoS One · 2012 Previous observational studies have reported associations between prostate cancer and alpha-linolenic acid (ALA). However, few investigations have been able to study this relationship prospectively and in well-controlled settings. Moreover, no studies have ... Full text Open Access Link to item Cite

Prostate cancer: ideal candidates for focal therapy.

Other Nat Rev Urol · December 13, 2011 Featured Publication Full text Link to item Cite

Methodology to register prostate B-mode and ARFI images to MR and histology

Conference IEEE International Ultrasonics Symposium, IUS · December 1, 2011 Acoustic Radiation Force Impulse (ARFI) imaging is being developed for guiding needle biopsy and focal therapy of Prostate cancer (PCa). In vivo ARFI images portray internal structures in the prostate with higher contrast than matched B-mode images. Given ... Full text Cite

Mn-porphyrins as novel molecular magnetic resonance imaging contrast agents.

Journal Article J Endourol · November 3, 2011 Featured Publication BACKGROUND AND PURPOSE: In this study, we investigated the potential of a new class of therapeutic Mn porphyrins as molecular MRI probes for prostate cancer imaging. Two compounds of different bioavailibility were investigated: Mn(III) meso-tetrakis(N-ethy ... Full text Link to item Cite

Treatment of localised renal cell carcinoma.

Journal Article Eur Urol · October 2011 Featured Publication CONTEXT: The increasing incidence of localised renal cell carcinoma (RCC) over the last 3 decades and controversy over mortality rates have prompted reassessment of current treatment. OBJECTIVE: To critically review the recent data on the management of loc ... Full text Link to item Cite

Understanding the pathological features of focality, grade and tumour volume of early-stage prostate cancer as a foundation for parenchyma-sparing prostate cancer therapies: active surveillance and focal targeted therapy.

Journal Article BJU Int · October 2011 Featured Publication OBJECTIVE: • To better understand the biology and incidence of the cancer foci within the prostate through a comprehensive literature review and a review of our own data, to establish the current level of knowledge regarding the pathological foundation for ... Full text Link to item Cite

Effect of low-fat diets on plasma levels of NF-κB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer.

Journal Article Cancer Prev Res (Phila) · October 2011 Featured Publication Diet, nutritional status, and certain dietary supplements are postulated to influence the development and progression of prostate cancer. Angiogenesis and inflammation are central to tumor growth and progression, but the effect of diet on these processes r ... Full text Link to item Cite

Factors predicting early and late phase decline of sexual health-related quality of life following radical prostatectomy.

Journal Article J Sex Med · October 2011 Featured Publication INTRODUCTION: The association between early and late phase sexual health-related quality of life (HRQoL) following radical prostatectomy (RP) is unclear. Moreover, factors that predict either early or late sexual HRQoL decline have not been fully investiga ... Full text Link to item Cite

3D Conformal and Intensity Modulated Radiotherapy to the Prostate Bed have Similar Biochemical Outcomes

Conference International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Neoadjuvant Radiotherapy plus Prostatectomy for High Risk Prostate Cancer

Conference International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Salvage radiation in men after prostate-specific antigen failure and the risk of death.

Journal Article Cancer · September 1, 2011 Featured Publication BACKGROUND: A survival benefit has been observed with salvage radiation therapy (RT) for prostate-specific antigen (PSA) failure after radical prostatectomy (RP) in men with rapid rises in PSA doubling time (DT, < 6 months). Whether such a benefit exits in ... Full text Link to item Cite

Renal function outcomes after laparoscopic renal cryoablation.

Journal Article J Endourol · August 2011 Featured Publication BACKGROUND AND PURPOSE: Laparoscopic cryoablation (LCA) has emerged as an alternative to conventional surgery for the management of a T(1) renal mass; however, only few data are available on its functional outcomes. We assessed renal function changes after ... Full text Link to item Cite

Radiation-induced erectile dysfunction using prostate-confined modern radiotherapy in a rat model.

Journal Article J Sex Med · August 2011 Featured Publication INTRODUCTION: The mechanisms of radiation-induced erectile dysfunction (ED) are unclear, as clinical studies are limited, and previous animal models were based on wide-field irradiation, which does not model current radiotherapy (RT) techniques. AIMS: To p ... Full text Link to item Cite

Prostate-specific antigen velocity based risk-adapted discontinuation of prostate cancer screening in elderly men.

Journal Article BJU Int · July 2011 Featured Publication OBJECTIVE: • To evaluate weather prostate-specific antigen (PSA) velocity could be used to stratify patients at risk of death from prostate cancer (PCa) and be useful in aiding decision making regarding PSA screening in elderly men, as previous studies hav ... Full text Link to item Cite

Renal function outcomes after laparoscopic renal cryoablation

Other International Braz J Urol · July 1, 2011 Background and Purpose: Laparoscopic cryoablation (LCA) has emerged as an alternative to conventional surgery for the management of a T(1) renal mass; however, only few data are available on its functional outcomes. We assessed renal function changes after ... Full text Cite

Use of 1,25α dihydroxyvitamin D3 as a cryosensitizing agent in a murine prostate cancer model.

Journal Article Prostate Cancer Prostatic Dis · June 2011 Featured Publication Cryotherapy has emerged as a primary treatment option for prostate cancer (CaP); however, incomplete ablation in the periphery of the cryogenic lesion can lead to recurrence. Accordingly, we investigated the use of a non-toxic adjunctive agent, vitamin D3 ... Full text Link to item Cite

Cigarette smoking is associated with advanced renal cell carcinoma.

Journal Article J Clin Oncol · May 20, 2011 Featured Publication PURPOSE: Cigarette smoking is a recognized risk factor for renal cell carcinoma (RCC), but little data are available on the association between smoking and RCC biology. We investigated the association between cigarette smoking and RCC stage in a large cont ... Full text Link to item Cite

Editorial comment.

Other Urology · May 2011 Featured Publication Full text Link to item Cite

Percutaneous cryoablation of renal lesions with radiographic ice ball involvement of the renal sinus: analysis of hemorrhagic and collecting system complications.

Journal Article AJR Am J Roentgenol · April 2011 Featured Publication OBJECTIVE: The purpose of this study was to determine the incidence of collecting system and hemorrhagic complications resulting from CT-guided percutaneous cryoablation of renal tumors in which the radiographic ice ball abuts or involves the renal sinus. ... Full text Link to item Cite

Clinical predictors of renal mass pathological features.

Journal Article BJU Int · March 2011 Featured Publication OBJECTIVE: • To evaluate the influence of radiographic tumour size and other preoperative variables on the pathological characteristics of the lesion to determine the distribution of pathological features and assess preoperative risk factors for potentiall ... Full text Link to item Cite

Can the conventional sextant prostate biopsy accurately predict unilateral prostate cancer in low-risk, localized, prostate cancer?

Journal Article Urol Oncol · 2011 Featured Publication We evaluate the reliability of routine sextant prostate biopsy to detect unilateral lesions. A total of 365 men with complete records including all clinical and pathologic variables who underwent a preoperative sextant biopsy and subsequent radical prostat ... Full text Link to item Cite

On-demand use of erectile aids in men with preoperative erectile dysfunction treated by whole gland prostate cryoablation.

Journal Article Int J Impot Res · 2011 Featured Publication Prostate cryoablation is an established minimally invasive treatment for localized prostate cancer (PCa). However, the impairment of erectile function (EF) is considered a serious complication of the procedure. To investigate the efficacy of erectile aids ... Full text Link to item Cite

Pathological T2 sub-divisions as a prognostic factor in the biochemical recurrence of prostate cancer.

Journal Article BJU Int · December 2010 Featured Publication OBJECTIVE: To determine the adequacy of T2 prostate cancer (PCa) sub-staging as an independent Predictor of biochemical disease-free survival (bDFS) after radical prostatectomy. MATERIALS AND METHODS: The Duke Prostate Center database was queried for patie ... Full text Link to item Cite

Adjuvant versus salvage radiation therapy for prostate cancer and the risk of death.

Journal Article BJU Int · December 2010 Featured Publication OBJECTIVE: To investigate whether salvage radiation therapy (RT) for prostate-specific antigen (PSA) failure can provide the same result as adjuvant RT, which decreases the risk of all-cause mortality (ACM) for men with positive margins (R1), or extra-caps ... Full text Link to item Cite

Analysis of urinary function using validated instruments and uroflowmetry after primary and salvage prostate cryoablation.

Journal Article Urology · November 2010 Featured Publication OBJECTIVES: To evaluate changes in urinary function after cryoablation for clinically localized prostate cancer and to investigate risk factors that predict changes in urinary function after surgery. METHODS: Among the patients who underwent primary or sal ... Full text Link to item Cite

Prostate-specific antigen-based risk-adapted discontinuation of prostate cancer screening in elderly African American and Caucasian American men.

Journal Article Urology · November 2010 Featured Publication OBJECTIVES: To evaluate the relationship between initial prostate-specific antigen (PSA) and prostate cancer (PCa) risk in elderly African American (AA) and Caucasian American (CA) men. METHODS: A total of 408 AA and 1720 CA men whose initial PSA measureme ... Full text Link to item Cite

A Modern Animal Model of Radiation-induced Erectile Dysfunction

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Baseline PSA as a predictor of prostate cancer-specific mortality over the past 2 decades: Duke University experience.

Journal Article Cancer · October 15, 2010 Featured Publication BACKGROUND: A diagnosis of prostate cancer is not often predictive of death from prostate cancer because of competing causes of mortality. Identification of the risk of death from prostate cancer and death from all causes using information available at the ... Full text Link to item Cite

Obese African-Americans with prostate cancer (T1c and a prostate-specific antigen, PSA, level of <10 ng/mL) have higher-risk pathological features and a greater risk of PSA recurrence than non-African-Americans.

Journal Article BJU Int · October 2010 Featured Publication OBJECTIVE: to analyse the relationship between African American (AA) race and obesity in men with prostate cancer. PATIENTS AND METHODS: in all, 4196 patients who underwent radical prostatectomy from 1988 to 2008 were identified in the Duke Prostate Center ... Full text Link to item Cite

Characterizing stiffness of human prostates using acoustic radiation force.

Journal Article Ultrason Imaging · October 2010 Featured Publication Acoustic Radiation Force Impulse (ARFI) imaging has been previously reported to portray normal anatomic structures and pathologies in ex vivo human prostates with good contrast and resolution. These findings were based on comparison with histological slide ... Full text Link to item Cite

Editorial comment.

Other Urology · September 2010 Featured Publication Full text Link to item Cite

Role of vitamin D(3) as a sensitizer to cryoablation in a murine prostate cancer model: preliminary in vivo study.

Journal Article Urology · September 2010 Featured Publication OBJECTIVES: Calcitriol has been reported to have antitumor efficacy in several cancers. In this study, we hypothesized that calcitriol may potentially function as a cryosensitizer that can enhance cryoablation, and we investigated several molecular marker ... Full text Link to item Cite

Predicting non-organ-confined prostate cancer in men diagnosed after 2000.

Journal Article Prostate Cancer Prostatic Dis · September 2010 Featured Publication The objective of this study was to preoperatively predict non-organ-confined disease in patients considering radical prostatectomy. To account for the stage migration seen in prostate cancer, we included only those patients who underwent prostatectomy afte ... Full text Link to item Cite

A NOVEL CO2-LASER PARTIAL NEPHRECTOMY: PILOT STUDY IN A PORCINE MODEL

Conference JOURNAL OF ENDOUROLOGY · September 1, 2010 Link to item Cite

Morphology of hypoxia following cryoablation in a prostate cancer murine model: its relationship to necrosis, apoptosis and, microvessel density.

Journal Article Cryobiology · August 2010 Featured Publication The aim of this study is to investigate the tumor tissue changes in terms of hypoxia and demonstrate its relationship to vascularity and apoptosis following therapeutic cryoablation in a prostate tumor murine model. Total 67 male C57BL/J6 mice were assigne ... Full text Link to item Cite

Complications of laparoscopic and percutaneous renal cryoablation in a single tertiary referral center.

Journal Article Eur Urol · July 2010 Featured Publication BACKGROUND: Laparoscopic cryoablation (LCA) and percutaneous cryoablation (PCA) of small renal masses have gained popularity, but only limited data exist on the complication rates. OBJECTIVES: In this study, we report on postoperative complications associa ... Full text Link to item Cite

Focal therapy for prostate cancer: possibilities and limitations.

Journal Article Eur Urol · July 2010 Featured Publication CONTEXT: A significant proportion of patients diagnosed with prostate cancer have well-differentiated, low-volume tumors at minimal risk of impacting their quality of life or longevity. The selection of a treatment strategy, among the multitude of options, ... Full text Link to item Cite

Predicting occult multifocality of renal cell carcinoma.

Journal Article Eur Urol · July 2010 Featured Publication BACKGROUND: Multifocal renal cell carcinoma (RCC) has been reported in up to 25% of all radical nephrectomy specimens. Modern imaging tends to underestimate the rate of multifocality. Recognition of multifocality before treatment may guide physicians and p ... Full text Link to item Cite

Integrin involvement in freeze resistance of androgen-insensitive prostate cancer.

Journal Article Prostate Cancer Prostatic Dis · June 2010 Featured Publication Cryoablation has emerged as a primary therapy to treat prostate cancer. Although effective, the assumption that freezing serves as a ubiquitous lethal stress is challenged by clinical experience and experimental evidence demonstrating time-temperature-rela ... Full text Link to item Cite

Prostate biopsy in selecting candidates for hemiablative focal therapy.

Journal Article J Endourol · May 2010 Featured Publication Focal therapy (FT) for the management of clinically localized prostate cancer (PCa) is growing from a concept to reality because of increased interest of both patients and physicians. Selection protocols, however, are yet to be established. We discuss the ... Full text Open Access Link to item Cite

Focal cryotherapy for prostate cancer.

Journal Article Curr Urol Rep · May 2010 Featured Publication Focal therapy for prostate cancer has emerged an interesting concept as a less morbid option for the treatment of localized low-risk disease. Despite the growing interest in focal therapy, this approach has not yet gained sufficient popularity nor provided ... Full text Link to item Cite

Contemporary results of focal therapy for prostate cancer using cryoablation.

Journal Article J Endourol · May 2010 Featured Publication The concept of focal therapy is rapidly evolving and gaining popularity from both physician and patient perspectives. We review the rationale, candidate selection, and results of the first clinical studies of focal cryoablation for selected patients with l ... Full text Open Access Link to item Cite

Prostate cancer: an evolving paradigm.

Journal Article J Endourol · May 2010 Featured Publication Since at least the early 1990s, stage and risk migration have been seen in patients with prostate cancer, likely corresponding to the institution of prostate specific antigen (PSA) screening in health systems. Preoperative risk factors, including PSA level ... Full text Open Access Link to item Cite

Public survey and survival data do not support recommendations to discontinue prostate-specific antigen screening in men at age 75.

Journal Article Urology · May 2010 Featured Publication OBJECTIVES: To evaluate the US Preventative Services Task Force (USPSTF) recommendation to discontinue prostate-specific antigen (PSA) screening at age 75. METHODS: Public survey: A cohort of 340 patients was surveyed at our PSA screening clinic and strati ... Full text Link to item Cite

Focal therapy in prostate cancer-report from a consensus panel.

Journal Article J Endourol · May 2010 PURPOSE: To establish a consensus in relation to case selection, conduct of therapy, and outcomes that are associated with focal therapy for men with localized prostate cancer. MATERIAL AND METHODS: Urologic surgeons, radiation oncologists, radiologists, a ... Full text Open Access Link to item Cite

Impact of postoperative prostate-specific antigen disease recurrence and the use of salvage therapy on the risk of death.

Journal Article Cancer · April 15, 2010 Featured Publication BACKGROUND: This report evaluated whether biochemical recurrence (BCR) as a time-dependent covariate (t) after radical prostatectomy (RP) for prostate cancer was associated with the risk of death and whether salvage therapy with radiotherapy (RT) and/or ho ... Full text Link to item Cite

Acoustic radiation force impulse imaging of human prostates ex vivo.

Journal Article Ultrasound Med Biol · April 2010 Featured Publication It has been challenging for clinicians using current imaging modalities to visualize internal structures and detect lesions inside human prostates. Lack of contrast among prostatic tissues and high false positive or negative detection rates of prostate les ... Full text Link to item Cite

Predicting unilateral prostate cancer on routine diagnostic biopsy: sextant vs extended.

Journal Article BJU Int · April 2010 Featured Publication OBJECTIVE: To compare the diagnostic properties of routine office-based sextant and extended biopsies for unilateral prostate cancer, as validated by final pathology, because focal therapy of prostate cancer is gaining acceptance as a viable treatment opti ... Full text Link to item Cite

Minimally invasive surgery using ablative modalities for the localized renal mass.

Journal Article Int J Urol · March 2010 Featured Publication Due to a number of evolving devices and modalities to treat the small, localized renal mass, the physician and patient have the opportunity to choose an appropriate therapy from several treatment options. Minimally invasive surgery to ablate a localized re ... Full text Link to item Cite

Initial prostate specific antigen 1.5 ng/ml or greater in men 50 years old or younger predicts higher prostate cancer risk.

Journal Article J Urol · March 2010 Featured Publication PURPOSE: Studies show that initial prostate specific antigen higher than the median in young men predicts a subsequent higher risk of prostate cancer. To our knowledge this relationship has not been studied in patients stratified by race. MATERIALS AND MET ... Full text Link to item Cite

Tumor percent involvement predicts prostate specific antigen recurrence after radical prostatectomy only in men with smaller prostate.

Journal Article J Urol · March 2010 Featured Publication PURPOSE: We determined the predictive power of tumor percent involvement on prostate specific antigen recurrence in patients when stratified by prostate weight. MATERIALS AND METHODS: Data on 3,057 patients who underwent radical prostatectomy between 1988 ... Full text Link to item Cite

Tumor size and endophytic growth pattern affect recurrence rates after laparoscopic renal cryoablation.

Journal Article Urology · February 2010 Featured Publication OBJECTIVE: To analyze factors that may contribute to local relapse after laparoscopic cryoablation (LCA) of renal tumors. LCA has gained popularity in the treatment of small renal tumors, but local tumor control remains a concern. METHODS: We analyzed 163 ... Full text Link to item Cite

Tumor volume, tumor percentage involvement, or prostate volume: which is predictive of prostate-specific antigen recurrence?

Journal Article Urology · February 2010 Featured Publication OBJECTIVES: To compare the effects of tumor volume (TV), tumor percentage involvement (TPI), and prostate volume (PV) on prostate-specific antigen (PSA) recurrence (PSAR) after radical prostatectomy (RP). METHODS: A cohort of 3528 patients receiving RP bet ... Full text Link to item Cite

Recent advances in focal therapy of prostate and kidney cancer.

Journal Article F1000 Med Rep · January 18, 2010 Featured Publication The concept of focal therapy in oncologic surgery refers to maximizing healthy tissue preservation while maintaining excellent cancer control outcomes. Herein, we address the recent advantages in the field of focal therapy for both kidney and prostate canc ... Full text Link to item Cite

Current salvage methods for recurrent prostate cancer after failure of primary radiotherapy.

Journal Article BJU Int · January 2010 Featured Publication We reviewed the current salvage methods for patients with local recurrent prostate cancer after primary radiotherapy (RT), using a search of relevant Medline/PubMed articles published from 1982 to 2008, with the following search terms: 'radiorecurrent pros ... Full text Link to item Cite

Utilization of (111)In-Capromab pendetide SPECT-CT for detecting seminal vesicle invasion with recurrent prostate cancer after primary in situ therapy.

Journal Article Int J Urol · December 2009 Featured Publication The aim of this study was to evaluate the diagnostic value of a hybrid (111)In-capromab pendetide fused computed tomography (CT) scan in detecting seminal vesicle invasion (SVI) in the setting of recurrent prostate cancer following primary in situ therapy. ... Full text Link to item Cite

Changes in Gleason score grading and their effect in predicting outcome after radical prostatectomy.

Journal Article Urology · November 2009 Featured Publication OBJECTIVES: To compare Gleason scores (GS) originally assigned in the mid 1990s with the current pathologic evaluation of the same prostatectomy slides, and to assess the GS migration effect on outcome in patients undergoing surgical treatment of prostate ... Full text Link to item Cite

Men older than 70 years have higher risk prostate cancer and poorer survival in the early and late prostate specific antigen eras.

Journal Article J Urol · November 2009 Featured Publication PURPOSE: We clarified whether men older than 70 years have a higher risk of prostate cancer and poorer survival in the early and late prostate specific antigen eras. MATERIALS AND METHODS: A cohort of 4,561 men who underwent radical prostatectomy were stra ... Full text Link to item Cite

Bisphosphonates in oncology: evidence for the prevention of skeletal events in patients with bone metastases.

Journal Article Drug Des Devel Ther · September 21, 2009 Featured Publication Bone metastases frequently occur in patients with advanced solid tumors, particularly breast and prostate cancers, and nearly all patients with multiple myeloma have some degree of skeletal involvement. The strides made in treating these primary tumors hav ... Link to item Cite

Use of 111in-capromab pendetide immunoscintigraphy to image localized prostate cancer foci within the prostate gland.

Journal Article J Urol · September 2009 Featured Publication PURPOSE: We compared the results of a preoperative (111)In-capromab pendetide scan co-registered with computerized tomography with pathological findings in the surgically excised prostate to determine whether the scan can efficiently detect cancer in the p ... Full text Link to item Cite

Delayed prostate-specific antigen recurrence after radical prostatectomy: how to identify and what are their clinical outcomes?

Journal Article Urology · September 2009 Featured Publication OBJECTIVES: To identify factors that predict delayed (> 5 years) prostate-specific antigen recurrence (PSAR) after radical prostatectomy (RP) and to analyze the associated clinical outcomes. METHODS: A cohort of 4561 men who underwent RP between 1988 and 2 ... Full text Link to item Cite

Effect of age and pathologic Gleason score on PSA recurrence: analysis of 2911 patients undergoing radical prostatectomy.

Journal Article Urology · September 2009 OBJECTIVES: To clarify the relationship between age and pathologic Gleason score and their effect on prostate-specific antigen recurrence (PSAR). METHODS: The data from a cohort of 2911 men who had undergone radical prostatectomy from 1988 to 2006 were ret ... Full text Link to item Cite

A retrospective comparison of anesthetic management of robot-assisted laparoscopic radical prostatectomy versus radical retropubic prostatectomy.

Journal Article J Clin Anesth · August 2009 Featured Publication STUDY OBJECTIVE: To compare anesthetic management and postoperative outcomes in patients undergoing robot-assisted laparoscopic radical prostatectomy (RALP) and radical retropubic prostatectomy (RRP) with general anesthesia. DESIGN: Retrospective database ... Full text Link to item Cite

Factors predicting prostatic biopsy Gleason sum under grading.

Journal Article J Urol · July 2009 Featured Publication PURPOSE: We determined clinical factors affecting the under grading of biopsy Gleason sum compared with prostatectomy pathology and developed a model predicting the probability of under grading. MATERIALS AND METHODS: We analyzed a cohort of 1,701 patients ... Full text Link to item Cite

Lidocaine patch for postoperative analgesia after radical retropubic prostatectomy.

Journal Article Anesth Analg · June 2009 Featured Publication In a prospective, double-blind, placebo-controlled study, patients undergoing radical retropubic prostatectomy under general anesthesia were randomly assigned to receive a lidocaine patch or placebo applied on each side of the wound at the end of surgery. ... Full text Link to item Cite

Patient selection for hemiablative focal therapy of prostate cancer: variables predictive of tumor unilaterality based upon radical prostatectomy.

Journal Article Cancer · May 15, 2009 Featured Publication BACKGROUND: The application of focal therapy for low-risk prostate cancer (PCa) depended on appropriate patient selection. No definitive criteria existed to characterize patients who may potentially benefit from an organ-sparing approach. We evaluated pret ... Full text Link to item Cite

Pathologic basis of focal therapy for early-stage prostate cancer.

Journal Article Nat Rev Urol · April 2009 Featured Publication The treatment paradigm for small-volume, low-grade unifocal or unilateral prostate cancer is shifting from a radical, whole-gland approach toward organ-sparing, focal ablation. The widely implemented screening program in the US has detected small-volume pr ... Full text Link to item Cite

Utility of a 3-dimensional transrectal ultrasound-guided prostate biopsy system for prostate cancer detection.

Journal Article Technol Cancer Res Treat · April 2009 Featured Publication The 3-D transrectal ultrasound (TRUS)-guided prostate biopsy system is a novel device that allows precise needle placement in a template fashion. We evaluate its utility for prostate cancer (PCa) detection. A retrospective analysis was performed evaluating ... Full text Link to item Cite

Focal Targeted Therapy Will Be a Future Treatment Modality for Early Stage Prostate Cancer

Journal Article European Urology, Supplements · April 1, 2009 Context: Focal targeted therapy of early stage prostate cancer (PCa) can ideally facilitate the concept of personalized medicine in contemporary surgical oncology. Objective: To present indications and outcomes of subtotal glandular ablation. This treatmen ... Full text Cite

PREDICTING NON-ORGAN CONFINED PROSTATE CANCER AFTER THE YEAR 2000

Journal Article The Journal of Urology · April 2009 Full text Cite

PERINEAL RADICAL PROSTATECTOMY: WHAT ARE THE TEN YEAR OUTCOMES?

Journal Article Journal of Urology · April 2009 Full text Cite

Prostate cancer: the new landscape.

Journal Article Curr Opin Urol · March 2009 Featured Publication PURPOSE OF REVIEW: This review highlights current features of the changing landscape of the US population with newly diagnosed prostate cancer and discusses new treatment options utilizing noninvasive or minimally invasive management. RECENT FINDINGS: Rece ... Full text Link to item Cite

Nerve-sparing focal cryoablation of prostate cancer.

Journal Article Curr Opin Urol · March 2009 Featured Publication PURPOSE OF REVIEW: We evaluate the rationale, candidate selection, and results of the first clinical studies of focal cryoablation for select patients with low volume and low-to-low - moderate risk features of prostate cancer as a possible alternative to w ... Full text Link to item Cite

Altered male physiologic function after surgery for prostate cancer: couple perspective.

Journal Article Int Braz J Urol · 2009 Featured Publication PURPOSE: Both the diagnosis of prostate cancer (PCa) and the physiologic outcomes of surgical treatment impact the male's psychological sphere. However, current research advocates a refocusing of outcomes directed to the PCa "couple". Herein we acquire ins ... Full text Link to item Cite

Concordance in the perception of couples recovering from primary surgical treatment of prostate cancer.

Journal Article Int J Impot Res · 2009 Featured Publication Although prostate cancer affects men, research shows effects on both members of the couple. We analyzed concordance in couples recovering from primary surgical treatment of prostate cancer when surveyed on psychological domains including emotional status, ... Full text Link to item Cite

Correlation between SWEI and ARFI image findings in ex vivo human prostates

Conference Proceedings - IEEE Ultrasonics Symposium · January 1, 2009 Acoustic Radiation Force Impulse (ARFI) imaging has previously been used to visualize normal anatomic structures and pathologies in both ex vivo and in vivo human prostates. Based on the relative displacement amplitudes in ARFI images and comparison with h ... Full text Cite

Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery.

Journal Article Cancer Epidemiol Biomarkers Prev · December 2008 Featured Publication BACKGROUND: Prostate cancer affects one of six men during their lifetime. Dietary factors are postulated to influence the development and progression of prostate cancer. Low-fat diets and flaxseed supplementation may offer potentially protective strategies ... Full text Link to item Cite

Three-dimensional acoustic radiation force impulse (ARFI) imaging of human prostates in vivo

Conference Proceedings - IEEE Ultrasonics Symposium · December 1, 2008 We are investigating utilizing ARFI imaging to guide prostate needle biopsy. Our previous ex vivo study demonstrated that ARFI imaging using a VF10-5 linear array was able to visualize the internal anatomy and suspicious lesions in the prostate, which may ... Full text Cite

Defining potency: a comparison of the International Index of Erectile Function short version and the Expanded Prostate Cancer Index Composite.

Journal Article Cancer · November 15, 2008 Featured Publication BACKGROUND: Both the 5-item short version of the International Index of Erectile Function (IIEF-5) and the Expanded Prostate Cancer Index Composite (EPIC) have been used to assess erectile function. In this study, the authors compared various definitions o ... Full text Link to item Cite

Persistent contrast enhancement several months after laparoscopic cryoablation of the small renal mass may not indicate recurrent tumor.

Journal Article J Endourol · November 2008 Featured Publication PURPOSE: We evaluated the clinical implication of persistent contrast enhancement demonstrated several months after laparoscopic renal cryoablation of a small renal mass. PATIENTS AND METHODS: Between September 2000 and May 2007, 30 patients underwent lapa ... Full text Link to item Cite

Significant discrepancies between diagnostic and pathologic Gleason sums in prostate cancer: the predictive role of age and prostate-specific antigen.

Journal Article Urology · October 2008 Featured Publication OBJECTIVES: To assess the discrepancies between diagnostic and pathologic Gleason sums and the predictive role of age and prostate-specific antigen (PSA) level on Gleason sum discrepancies. METHODS: A total of 2963 patients receiving radical prostatectomy ... Full text Link to item Cite

Pathologic stage T2a and T2b prostate cancer in the recent prostate-specific antigen era: implications for unilateral ablative therapy.

Journal Article Prostate · September 15, 2008 Featured Publication BACKGROUND: Early detection of small volume prostate cancer (PCa) has led to the concept of focal therapy to treat in an organ-sparing manner. We evaluated trends in pathologic staging among patients with localized PCa undergoing radical prostatectomy (RP) ... Full text Link to item Cite

Urothelial sloughing with obstruction after laparoscopic cryoablation of small renal carcinoma in solitary kidney.

Journal Article Urology · September 2008 Featured Publication Laparoscopic cryoablation is a minimally invasive treatment that is currently used to treat small renal tumors. Despite its growing use and promising outcomes, complications can occur. We report the first clinical case of urothelial sloughing with obstruct ... Full text Link to item Cite

Transdermal nicotine for analgesia after radical retropubic prostatectomy.

Journal Article Anesth Analg · September 2008 Featured Publication BACKGROUND: Previous animal and human studies suggested that nicotine might have an antinociceptive effect. We hypothesized that the preoperative application of a 7 mg nicotine patch would result in reduced postoperative analgesic requirements in patients ... Full text Link to item Cite

Evaluation of a novel precision template-guided biopsy system for detecting prostate cancer.

Journal Article BJU Int · August 5, 2008 Featured Publication OBJECTIVE: To explore the ability of a novel transrectal ultrasonography (TRUS) device (TargetScan, Envisioneering Medical Technologies, St. Louis MO) that creates a three-dimensional map of the prostate and calculates an optimal biopsy scheme, to accurate ... Full text Link to item Cite

Impact of a cryotherapy training workshop on the adoption and utilization of cryotherapy in the community setting.

Journal Article Can J Urol · August 2008 Featured Publication INTRODUCTION: Given the improved therapeutic efficacy and acceptable side effect profile with current cryotechnology, we wish to better understand the attitudes of community urologists expressing interest in this treatment modality toward the adoption of c ... Link to item Cite

The effect of cryoablation on the histologic interpretation of intraoperative biopsy of small clear cell renal carcinoma and renal oncocytoma.

Journal Article J Endourol · August 2008 Featured Publication BACKGROUND AND PURPOSE: We evaluated the effects of the first freeze-thaw cycle of cryoablation on Fuhrman grade, histology, and tumor architecture of small clear cell renal carcinomas and renal oncocytomas using an 18-gauge needle biopsy. PATIENTS AND MET ... Full text Link to item Cite

From whole-gland to targeted cryoablation for the treatment of unilateral or focal prostate cancer.

Journal Article Oncology (Williston Park) · July 2008 Featured Publication The intermediate and long-term results of primary full-gland cryoablation for localized prostate cancer with moderate- and high-risk patients suggests a cancer control rate similar to what can be achieved with radiotherapy and surgery, with an acceptable r ... Link to item Cite

Comparison of prostate-specific antigen recurrence-free survival in a contemporary cohort of patients undergoing either radical retropubic or robot-assisted laparoscopic radical prostatectomy.

Journal Article BJU Int · July 2008 Featured Publication OBJECTIVES: To compare the prostate-specific antigen (PSA) recurrence (PSAR) rates in patients undergoing robot-assisted laparoscopic radical prostatectomy (RALP) or radical retropubic prostatectomy (RRP). PATIENTS AND METHODS: Data from 797 consecutive pa ... Full text Link to item Cite

Editorial Comment

Other Journal of Urology · June 2008 Full text Cite

Can prostate-specific antigen and prostate-specific antigen velocity be used for prostate cancer screening in men older than 70 years?

Journal Article Urology · June 2008 Featured Publication OBJECTIVES: We evaluated the lower threshold of prostate-specific antigen (PSA) and prostate-specific antigen velocity (PSAV) in a population of men over 70 years of age. METHODS: Between January 1988 and December 2005, 4038 men over 70 years of age includ ... Full text Link to item Cite

Use of local (111)in-capromab pendetide scan results to predict outcome after salvage radiotherapy for prostate cancer.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2008 Featured Publication PURPOSE: The (111)In-capromab pendetide scan (ProstaScint; Cytogen Corp., Princeton NJ) is approved by the Food and Drug Administration to evaluate increasing prostate-specific antigen (PSA) levels after radical prostatectomy. This study evaluated the role ... Full text Link to item Cite

Editorial Comment

Other Journal of Urology · June 1, 2008 Full text Cite

WITHDRAWN: Can the conventional sextant prostate biopsy reliably diagnose unilateral prostate cancer in low-risk, localized, prostate cancer?

Other Prostate Cancer Prostatic Dis · May 13, 2008 Featured Publication The authors hereby retract the e-publication dated 13 May 2008 and entitled, 'Can the conventional sextant prostate biopsy reliably diagnose unilateral prostate cancer in low-risk, localized, prostate cancer?' The authors are submitting a revised version w ... Full text Link to item Cite

Focal therapy for prostate cancer.

Journal Article Curr Opin Urol · May 2008 Featured Publication PURPOSE OF REVIEW: Nowadays the treatment paradigm for localized prostate cancer is to distinguish patients with clinically relevant cancers who may benefit from radical treatment, or perhaps an organ-sparing approach, from the remainder who may not need i ... Full text Link to item Cite

Zoledronic acid in the management of metastatic bone disease.

Journal Article Ther Clin Risk Manag · February 2008 Featured Publication Many patients with advanced cancer experience decreased bone strength due to metastatic foci, underlying osteoporosis and/or cancer treatment induced bone loss. The clinical consequences of metastatic disease involving the skeleton are widespread. This rev ... Full text Link to item Cite

Bone health in prostate cancer patients receiving androgen-deprivation therapy: the role of bisphosphonates.

Journal Article Prostate Cancer Prostatic Dis · 2008 Featured Publication Androgen-deprivation therapy, a mainstay in the treatment of locally advanced and metastatic prostate cancer, is associated with significant bone loss and related complications, such as fracture. Bisphosphonates, osteoclast inhibitors, are effective in pre ... Full text Link to item Cite

Overcoming challenges in designing and implementing a phase II randomized controlled trial using a presurgical model to test a dietary intervention in prostate cancer.

Journal Article Clin Trials · 2008 Featured Publication BACKGROUND: The time between the diagnosis of cancer and a planned definitive surgical procedure offers a strong and direct approach for assessing the impact of interventions (including lifestyle interventions) on the biology of the target tissue and the t ... Full text Link to item Cite

Avoiding surgery in prostate cancer patients with low-risk disease

Journal Article Therapy · January 1, 2008 At present, the treatment paradigm for localized prostate cancer (PCa) is to distinguish patients with clinically relevant cancers who require treatment either in the form of traditional radical therapy or a contemporary less aggressive, organ-preserving a ... Full text Cite

Short Term Clinical Outcome after Laparoscopic Cryoablation of the Renal Tumor < or = 3.5 cm.

Journal Article Technol Cancer Res Treat · December 2007 Featured Publication Between September 2000 and September 2006, 26 patients underwent primary laparoscopic cryosurgical procedures (28) for an organ-confined renal tumor(s). In one case, cryosurgery was done sequentially on both kidneys. All patients had been carefully selecte ... Full text Link to item Cite

Prostate cancer laterality does not predict prostate-specific antigen recurrence after radical prostatectomy.

Journal Article Urology · December 2007 Featured Publication OBJECTIVES: To evaluate biologic behaviors of unilateral cancers compared with bilateral cancers on prostate-specific antigen (PSA) recurrence after radical prostatectomy. METHODS: Analysis included demographic, clinical, and pathologic parameters of 1184 ... Full text Link to item Cite

Visualizing the anatomic structures of human prostates using Acoustic Radiation Force Impulse (ARFI) imaging

Conference Proceedings - IEEE Ultrasonics Symposium · December 1, 2007 McNeal's zonal anatomy for prostate has been the standard anatomical model for human prostate for about 30 years. It divides a human prostate into one non-glandular zone (the anterior flbromuscular stroma), and three glandular zones (central zone (CZ), tra ... Full text Cite

Prostate cancer laterality as a rationale of focal ablative therapy for the treatment of clinically localized prostate cancer.

Journal Article Cancer · August 15, 2007 Featured Publication BACKGROUND: Early detection of small-volume prostate cancer (PCa) has led to the concept of focal therapy to treat PCa as an organ-sparing, minimally invasive procedure. The authors sought to determine the frequency of unilateral cancers in the contemporar ... Full text Link to item Cite

Prostatic abscess as a delayed complication following cryosurgery for primary prostate cancer.

Journal Article Can J Urol · August 2007 Featured Publication Prostatic abscess is a rare and potentially life-threatening disease when left untreated. We report the first case of a man who developed a prostatic abscess as a long-term complication of cryoablation for primary prostate cancer. Timely diagnosis with non ... Link to item Cite

Short-term cancer control after primary cryosurgical ablation for clinically localized prostate cancer using third-generation cryotechnology.

Journal Article Urology · July 2007 Featured Publication OBJECTIVES: Percutaneous perineal cryoablation of the prostate is a promising technique in the treatment armamentarium for clinically localized prostate carcinoma. We report our initial experience using a transrectal ultrasound-guided, third-generation, ar ... Full text Link to item Cite

Ureteropelvic junction obliteration resulting in nephrectomy after radiofrequency ablation of small renal cell carcinoma.

Journal Article Urology · May 2007 Featured Publication Percutaneous radiofrequency ablation is a minimally invasive treatment that is currently used to treat renal tumors. Despite its minimally invasive nature, potential serious complications can occur. We report the second case of ureteropelvic junction obstr ... Full text Link to item Cite

Rectourethral fistula after combination radiotherapy for prostate cancer.

Journal Article Urology · May 2007 Featured Publication OBJECTIVES: To describe 6 cases of rectourethral fistula in patients treated with brachytherapy plus external beam radiotherapy for localized prostate cancer and subsequent rectal biopsies or rectal surgery. METHODS: A retrospective chart review was undert ... Full text Link to item Cite

Analysis of laterality and percentage of tumor involvement in 1386 prostatectomized specimens for selection of unilateral focal cryotherapy.

Journal Article Technol Cancer Res Treat · April 2007 Featured Publication In total, 1386 paraffin embedded radical prostatectomy specimens from patients with clinically localized prostate cancer (PCa) excised between 2002-06 were analyzed. Pathologic assessment paid particular attention to laterality and percentage of tumor invo ... Full text Link to item Cite

The role of early adopter bias for new technologies in robot assisted laparoscopic prostatectomy.

Journal Article J Urol · April 2007 Featured Publication PURPOSE: We determined the potential influence of an early adopter bias in patients undergoing robot assisted laparoscopic prostatectomy. MATERIALS AND METHODS: We compared baseline demographic, clinical and health related quality of life characteristics o ... Full text Link to item Cite

Prostate-specific antigen (PSA) and PSA velocity for prostate cancer detection in men aged <50 years.

Journal Article BJU Int · April 2007 Featured Publication OBJECTIVE: To identify threshold values of prostate-specific antigen (PSA) levels and PSA velocity (PSAV) to optimize the assessment of the risk of prostate cancer in young men, as prostate cancer is detected increasingly in men aged <50 years. PATIENTS AN ... Full text Link to item Cite

Issues critical to the successful application of cryosurgical ablation of the prostate.

Journal Article Technol Cancer Res Treat · April 2007 The techniques of present-day cryosurgery performed with multiprobe freezing apparatus and advanced imaging techniques yield predictable and encouraging results in the treatment of prostatic and renal cancers. Nevertheless, and not unique to cryosurgical t ... Full text Link to item Cite

Comparative financial analysis of minimally invasive surgery to open surgery for small renal tumours < or =3.5 cm: a single institutional experience.

Journal Article Eur Urol · March 2007 Featured Publication OBJECTIVE: We analysed total hospital costs by comparing minimally invasive surgery (MIS) procedures, such as laparoscopic cryoablation (LCA), laparoscopic partial nephrectomy (LPN), and hand-assisted laparoscopic nephrectomy (HALN), with conventional surg ... Full text Link to item Cite

Current status of minimally invasive ablative techniques in the treatment of small renal tumours.

Journal Article Eur Urol · February 2007 Featured Publication OBJECTIVES: In the current era, minimally invasive surgery using ablative techniques for the treatment of small renal tumours has become a more common and feasible treatment option. In this review, we present recent data regarding the utility of needle abl ... Full text Link to item Cite

Financial comparative analysis of minimally invasive surgery to open surgery for localized prostate cancer: a single-institution experience.

Journal Article Urology · February 2007 Featured Publication OBJECTIVES: To evaluate the financial implications of how the costs of new minimally invasive surgery such as laparoscopic robotic prostatectomy (LRP) and cryosurgical ablation of the prostate (CAP) technologies compare with those of conventional surgery. ... Full text Link to item Cite

Age adjusted prostate specific antigen and prostate specific antigen velocity cut points in prostate cancer screening.

Journal Article J Urol · February 2007 Featured Publication PURPOSE: We identified age adjusted prostate specific antigen and prostate specific antigen velocity cut points for prostate cancer biopsy. MATERIALS AND METHODS: A cohort of 33,643 men was retrieved from the Duke Prostate Center database. Of this group 11 ... Full text Link to item Cite

Malignant cystic nephroma.

Journal Article Can J Urol · December 2006 Featured Publication AIM: To describe a malignant cystic nephroma in an asymptomatic man. METHODS: Case report and review of the literature. RESULTS: A 60 year old white male presented with an incidentally discovered right perirenal mass. An MRI demonstrated a large perinephri ... Link to item Cite

Multiple nephron-sparing procedures in solitary kidney with recurrent, metachronous, nonfamilial renal cell carcinoma.

Journal Article Urology · December 2006 Featured Publication Patients with metachronous bilateral renal cell carcinoma pose a significant challenge given the high mortality of renal cell carcinoma and the poor quality of life should dialysis become necessary. In addition, patients may be subject to morbidity due to ... Full text Link to item Cite

Effect of freeze time during renal cryoablation: a swine model.

Journal Article J Endourol · December 2006 Featured Publication BACKGROUND AND PURPOSE: Cryotherapy provides a minimally invasive treatment for small renal tumors via an open, percutaneous, or laparoscopic approach. We sought to determine the most appropriate duration of freezing and the number of probes necessary to p ... Full text Link to item Cite

Editorial comment

Other Journal of Urology · June 1, 2006 Full text Cite

Update on cryotherapy for prostate cancer in 2006.

Journal Article Curr Opin Urol · May 2006 Featured Publication PURPOSE OF REVIEW: With the recent introduction of novel, minimally invasive procedures for the treatment of prostate cancer, cryotherapy has become a feasible option as a viable alternative to traditional radical surgery and radiation therapy. In this rev ... Full text Link to item Cite

Ovarian hyperstimulation causing ureteral obstruction in a pregnant woman.

Journal Article Urology · May 2006 Featured Publication Obstruction of the urinary collecting system in pregnant women can present a unique challenge to the urologist. Although ureteral obstruction due to stone disease is well-documented and ureteral obstruction is a well-known and defined cause of acute renal ... Full text Link to item Cite

Preventing bone loss in patients with hormone-sensitive prostate cancer and bone metastases

Journal Article American Journal of Urology Review · April 1, 2006 Cite

Laparoscopic renal cryoablation for tumors less than 3.5 cm

Conference JOURNAL OF ENDOUROLOGY · 2006 Cite

Salvage prostate cryoablation after primary interstitial brachytherapy failure: a feasible approach.

Journal Article Prostate Cancer Prostatic Dis · 2006 Featured Publication Salvage treatment for recurrent prostate cancer remains a very difficult and challenging field in urologic oncology. The introduction of minimally invasive surgical procedures such a targeted cryoablation brings some hope with its feasibility and efficacy ... Full text Link to item Cite

Laparoscopic ureteroureterostomy for retrocaval ureter

Journal Article European Urology, Supplements · January 1, 2006 Objectives: To debate the different laparoscopic approaches for the surgical management of patients with circumcaval ureter. Methods: Updated literature review and discussion of personal experiences concerning the laparoscopic treatment of the circumcaval ... Full text Cite

Complications after percutaneous radiofrequency ablation of renal tumors.

Journal Article Urology · December 2005 Featured Publication OBJECTIVES: To evaluate our experience with percutaneous radiofrequency ablation (pRFA) to determine common characteristics of patients with complications, to elucidate possible relative contraindications to therapy. METHODS: Medical records of all patient ... Full text Link to item Cite

Open-label trial evaluating the safety and efficacy of zoledronic acid in preventing bone loss in patients with hormone-sensitive prostate cancer and bone metastases.

Journal Article Urology · November 2005 Featured Publication OBJECTIVES: To evaluate the efficacy and safety of zoledronic acid in preventing bone loss in patients with hormone-sensitive prostate cancer and bone metastases who were receiving androgen deprivation therapy. METHODS: Patients received zoledronic acid 4 ... Full text Link to item Cite

Supplement use among men with prostate cancer.

Journal Article Urology · July 2005 Featured Publication OBJECTIVES: To characterize supplement use within a sample population of men diagnosed with prostate cancer. METHODS: A census of men diagnosed with prostate cancer at Duke University Medical Center from 1997 to 2002 (n = 1402) was mailed a survey that asc ... Full text Link to item Cite

Renal cryoablation and radio frequency ablation: an evaluation of worst case scenarios in a porcine model.

Journal Article J Urol · June 2005 Featured Publication PURPOSE: Although ablative technologies, including radio frequency (RF) ablation (RFA) and cryoablation (CA), are being used to treat renal masses, complications associated with injury to vital renal structures are not well understood. We investigated thes ... Full text Link to item Cite

Does prior benign prostate biopsy predict outcome for patients treated with radical perineal prostatectomy?

Journal Article Urology · February 2005 Featured Publication OBJECTIVES: To determine the effect of prior benign prostate biopsies on the surgical and clinical outcomes of patients treated with radical perineal prostatectomy for prostate cancer. METHODS: A total of 1369 patients with clinically localized prostate ca ... Full text Link to item Cite

ProstaScint (capromab pendetide) imaging using hybrid gamma camera-CT technology.

Journal Article AJR Am J Roentgenol · February 2005 Featured Publication Full text Link to item Cite

Promoter hypermethylation profile of kidney cancer.

Journal Article Clin Cancer Res · June 15, 2004 Featured Publication PURPOSE: Promoter hypermethylation is an important mechanism of inactivation of tumor suppressor genes in cancer cells. Kidney tumors are heterogeneous in their histology, genetics, and clinical behavior. To gain insight into the role of epigenetic silenci ... Full text Link to item Cite

Pilot study to explore effects of low-fat, flaxseed-supplemented diet on proliferation of benign prostatic epithelium and prostate-specific antigen.

Journal Article Urology · May 2004 Featured Publication OBJECTIVES: Dietary factors may influence the prostate and have an impact on prostatic growth and disease. A small number of studies have suggested that flaxseed-supplemented, fat-restricted diets may thwart prostate cancer growth in both animals and human ... Full text Link to item Cite

Renal radiofrequency ablation: Worst case scenarios in a porcine model

Conference AMERICAN JOURNAL OF ROENTGENOLOGY · January 1, 2004 Link to item Cite

Liposarcoma presenting as an intraluminal ureteral mass.

Journal Article Urology · May 2003 Featured Publication An 86-year-old woman with a previous excision of a large retroperitoneal low-grade liposarcoma presented with a 4-month history of persistent left flank discomfort. Workup revealed left hydronephrosis secondary to obstruction, which was caused by a recurre ... Full text Link to item Cite

Use of bipolar laparoscopic forceps to occlude and transect the retroperitoneal vasculature: a porcine model.

Journal Article J Endourol · April 2003 Featured Publication BACKGROUND AND PURPOSE: Surgical clips are commonly employed during laparoscopic radical nephrectomy to ligate perihilar vessels reliably, yet these clips can interfere with the application of a vascular stapler to major vessels, potentially leading to cat ... Full text Link to item Cite

Management of small renal tumors with radiofrequency ablation.

Journal Article Urology · January 2003 Featured Publication Full text Link to item Cite

Comparison of [18 F]fluorocholine and [18 F]fluorodeoxyglucose for positron emission tomography of androgen dependent and androgen independent prostate cancer.

Journal Article J Urol · July 2002 Featured Publication PURPOSE: Positron emission tomography (PET) imaging is used for the metabolic evaluation of cancer. [18F]fluorodeoxyglucose (FDG) is commonly used as a radiotracer but its low cellular uptake rate in prostate cancer limits its usefulness. We evaluated the ... Link to item Cite

Hypertonic saline-augmented radiofrequency ablation of the VX-2 tumor implanted in the rabbit kidney: a short-term survival pilot study.

Journal Article Urology · July 2002 Featured Publication OBJECTIVES: The increased incidental detection of small (less than 4 cm) renal tumors has stimulated investigations of minimally invasive therapies. Radiofrequency energy is a relatively new and evolving technology that has been used for a variety of exper ... Full text Link to item Cite

Clinical utility of indium 111-capromab pendetide immunoscintigraphy in the detection of early, recurrent prostate carcinoma after radical prostatectomy.

Journal Article Cancer · February 15, 2002 Featured Publication BACKGROUND: Despite the ability of radical prostatectomy to eradicate prostate carcinoma, biochemical evidence of recurrent prostate carcinoma may be seen in approximately 40% of patients 15 years after they undergo surgery. Localization of recurrent disea ... Link to item Cite

Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features.

Journal Article Urology · July 2001 Featured Publication OBJECTIVES: Dietary fat and fiber affect hormonal levels and may influence cancer progression. Flaxseed is a rich source of lignan and omega-3 fatty acids and may thwart prostate cancer. The potential effects of flaxseed may be enhanced with concomitant fa ... Full text Link to item Cite

Management of small renal tumors: an overview.

Journal Article Am J Med · May 2001 Featured Publication The incidental finding of a small renal mass poses a therapeutic dilemma. The traditional treatment of clinically important masses has been radical nephrectomy. Recently, nephron-sparing surgery has emerged as a viable alternative; and experimental minimal ... Full text Link to item Cite

Utility of capromab pendetide (ProstaScint) imaging in the management of prostate cancer.

Journal Article Tech Urol · March 2001 Featured Publication PURPOSE: Capromab pendetide (ProstaScint) is an indium In 111 ((111)In)-labeled monoclonal antibody to prostate-specific membrane antigen (PSMA) used to image prostate cancer. The appropriate techniques for obtaining images with this modality and the appro ... Link to item Cite

Synthesis and evaluation of 18F-labeled choline as an oncologic tracer for positron emission tomography: initial findings in prostate cancer.

Journal Article Cancer Res · January 1, 2001 Featured Publication The up-regulation of rates of choline uptake and phosphorylation in certain malignancies has motivated the development of positron-labeled choline analogues for noninvasive detection of cancer using positron emission tomography (PET). The choline analogue, ... Link to item Cite

Survey of neuromuscular injuries to the patient and surgeon during urologic laparoscopic surgery.

Journal Article Urology · June 2000 Featured Publication OBJECTIVES: Laparoscopy may be complicated by neuromuscular injuries, both to the patient and to the surgeon. We used a survey to estimate the incidence of these injuries during urologic laparoscopic surgery, to assess risk factors for these injuries, and ... Full text Link to item Cite

Capromab Pendetide imaging of prostate cancer.

Journal Article Cancer Biother Radiopharm · April 2000 Featured Publication Capromab Pendetide imaging illustrates the successful translation of monoclonal antibody technology from the laboratory to the clinic. It provides a means of identifying otherwise occult soft tissue metastases in patients with adenocarcinoma of the prostat ... Full text Link to item Cite

Prostate specific antigen: a decade of discovery--what we have learned and where we are going.

Journal Article J Urol · August 1999 Featured Publication PURPOSE: Many advances have occurred during the last decade in the clinical use of prostate specific antigen (PSA) for detecting, staging and monitoring prostate cancer. We review the clinical usefulness and limitations of serum PSA as a tumor marker of pr ... Full text Link to item Cite

Comparison of clinical staging algorithms and 111indium-capromab pendetide immunoscintigraphy in the prediction of lymph node involvement in high risk prostate carcinoma patients.

Journal Article Cancer · April 1, 1999 Featured Publication BACKGROUND: The pretherapy prediction of occult lymph node involvement and the avoidance of otherwise futile and potentially morbid definitive local therapy is paramount in men with newly diagnosed prostate carcinoma. To identify patients with prostate car ... Link to item Cite

Ablation of renal tumors in a rabbit model with interstitial saline-augmented radiofrequency energy: preliminary report of a new technology.

Journal Article Urology · March 1999 Featured Publication ObjectivesTo evaluate the efficacy of interstitial saline radiofrequency energy for reproducibly ablating nonmalignant (control) and malignant (the VX-2 tumor) renal tissue in a rabbit model, and to determine the ability of conventional gray-scale ... Full text Cite

Use of multivariate models to improve prediction of pathologic stage for men with clinically localized prostate cancer.

Journal Article Prostate Cancer Prostatic Dis · December 1998 Featured Publication To benefit from definitive local therapy, men with clinically localized prostate cancer should have organ-confined disease. We discuss the use of multivariate analysis using serum PSA, biopsy Gleason score and clinical stage to improve the prediction of pa ... Full text Link to item Cite

Frequent occurrence of metastatic disease in patients with renal cell carcinoma and intrahepatic or supradiaphragmatic intracaval extension treated with surgery: an outcome analysis.

Journal Article Urology · December 1998 Featured Publication OBJECTIVES: Previous reports indicate that up to 10% of patients with localized renal cell carcinoma have direct intracaval neoplastic extension. Many patients with locally confined tumors and small intracaval tumor extensions can be surgically cured. Few ... Full text Link to item Cite

Multivariate models as predictors of pathological stage using Gleason score, clinical stage, and serum prostate-specific antigen.

Journal Article Semin Urol Oncol · August 1998 Featured Publication The patient presented is a 58-year-old man with newly diagnosed prostate cancer who likely has at least a 10- to 15-year life expectancy. In staging this man's extent of disease, several preoperative clinical variables are provided to assess whether the pa ... Link to item Cite

Laparoscopic ureteroureterostomy for retrocaval ureter.

Journal Article J Urol · July 1998 Featured Publication Link to item Cite

Comparison of radical prostatectomy and iodine 125 interstitial radiotherapy for the treatment of clinically localized prostate cancer: a 7-year biochemical (PSA) progression analysis.

Journal Article Urology · June 1998 Featured Publication OBJECTIVES: To evaluate the relative efficacy of brachytherapy to radical prostatectomy, we compared biochemical progression rates from a published series of men who underwent iodine 125 (125I) interstitial radiotherapy for localized prostate cancer to a s ... Link to item Cite

Long-term survival after radical nephrectomy with intrahepatic or supradiaphragmatic intracaval thrombectomy for renal cell carcinoma

Other British Journal of Urology · December 1, 1997 Purpose: Four to ten percent of patients with renal cell carcinoma have direct extension of tumor into the inferior vena cava. Although many patients, particularly those with locally confined lesions and small intracaval tumor extensions, may be surgical c ... Cite

Partial nephrectomy: technique, complications and pathologic findings

Other British Journal of Urology · December 1, 1997 Small renal tumors are being discovered more commonly because of frequent radiologie examinations for a variety of symptoms. Partial nephrectomy rather than radical nephrectomy has been considered in many of these patients in order to conserve renal tissue ... Cite

High-density mapping of chromosomal arm 1q in renal collecting duct carcinoma: region of minimal deletion at 1q32.1-32.2.

Journal Article Cancer Res · November 1, 1996 Featured Publication Collecting duct carcinoma (CDC) of the kidney is a rare malignant neoplasm of distal nephron origin. Previous studies of CDC have shown loss of heterozygosity on chromosomal arm 1q in 57% of the cases studied. To better characterize 1q loss in CDC, we perf ... Link to item Cite

Reappraisal of the role of human chorionic gonadotropin in the diagnosis and treatment of the nonpalpable testis: a 10-year experience.

Journal Article J Urol · August 1996 Featured Publication PURPOSE: We retrospectively evaluated the ability of human chorionic gonadotropin (HCG) to make the nonpalpable cryptorchid testis become palpable and promote testicular descent. MATERIALS AND METHODS: Through surgical bookings we identified 94 patients yo ... Full text Link to item Cite

Distal nephron renal tumors: microsatellite allelotype.

Journal Article Cancer Res · April 15, 1996 Featured Publication Tumors of varying malignant potential arise from the complex epithelial lining of the nephron. Although the molecular characteristics of renal clear cell carcinomas, which arise from the proximal tubule, have been studied, little is known about tumors that ... Link to item Cite

Distinct regions of allelic loss on chromosome 4 in human primary bladder carcinoma.

Journal Article Cancer Res · November 15, 1995 Featured Publication Accumulating evidence implicates the presence of putative tumor suppressor genes on human chromosome 4 that are potentially inactivated in the genesis of several different neoplasms. To accurately determine the frequency of allelic loss on both arms of hum ... Link to item Cite

Intraoperative sonography for the evaluation and management of renal tumors: experience with 100 patients.

Journal Article J Urol · November 1995 Featured Publication PURPOSE: Intraoperative sonography was used to evaluate prospectively the renal parenchyma of patients undergoing surgery for presumed renal neoplasia. MATERIALS AND METHODS: One surgeon (F.F.M.) evaluated 100 kidneys using a triple-head sector ultrasonic ... Link to item Cite

Partial nephrectomy: technique, complications and pathological findings.

Journal Article J Urol · October 1995 Featured Publication PURPOSE: We evaluate whether partial nephrectomy can be performed safely and efficaciously for renal tumors. MATERIALS AND METHODS: The results of 67 partial nephrectomies performed between 1977 and 1994 for renal cell carcinoma (51), oncocytoma (9), angio ... Full text Link to item Cite

Frequency of homozygous deletion at p16/CDKN2 in primary human tumours.

Journal Article Nat Genet · October 1995 Featured Publication Many tumour types have been reported to have deletion of 9p21 (refs 1-6). A candidate target suppressor gene, p16 (p16INK4a/MTS-1/CDKN2), was recently identified within the commonly deleted region in tumour cell lines. An increasing and sometimes conflicti ... Full text Link to item Cite

Novel suppressor loci on chromosome 14q in primary bladder cancer.

Journal Article Cancer Res · August 1, 1995 Featured Publication Two hundred eighty-five primary human carcinomas of the urinary bladder were examined for allelic loss on chromosome 14q. Seventeen highly polymorphic dinucleotide markers spanning the long arm of this acrocentric chromosome were selected for fine PCR-base ... Link to item Cite

Radical retropubic prostatectomy: the influence of accessory pudendal arteries on the recovery of sexual function.

Journal Article J Urol · July 1995 Featured Publication Arterial insufficiency is a major factor responsible for impotence in men following nerve sparing radical prostatectomy. Previously, accessory internal pudendal arteries have been identified traveling over the anterolateral surface of the prostate. Based o ... Full text Link to item Cite

Comparison of laparoscopic and open retropubic urethropexy for treatment of stress urinary incontinence.

Journal Article Urology · April 1995 Featured Publication OBJECTIVES: Laparoscopic retropubic urethropexy has recently been described as an alternative method to the surgical correction of pure stress urinary incontinence. This study compares the operative technique and results of laparoscopic colposuspension wit ... Full text Link to item Cite

Radical prostatectomy in men less than 50 years old.

Journal Article Urol Oncol · 1995 Featured Publication We studied the effect of age on tumor progression (defined as postoperative prostate specific antigen elevation) in 543 men who underwent radical prostatectomy for clinically localized prostate cancer. Patients were divided into two age groups: patients un ... Full text Link to item Cite

Equivalent antihypertensive effects of combination therapy using diuretic + calcium antagonist compared with diuretic + ACE-inhibitor

Journal Article Journal of Human Hypertension · December 1990 To test the hypothesis that the combination of a calcium antagonist and diuretic is less effective in lowering BP than the combination of ACE inhibitor plus diuretic, we compared two groups of patients. The first was a group of 157 consecutive patients (32 ... Cite

Neomycin cannot be used as a selective inhibitor of inositol phospholipid hydrolysis in intact or semi-permeabilized human platelets. Aminoglycosides activate semi-permeabilized platelets

Journal Article Biochemical Journal · May 1, 1987 High concentrations of neomycin (2-10 mM) inhibited aggregation, but not shape change, of intact platelets by collagen, ADP and the Ca2+ ionophore, A23187, the last two studies being carried out in the presence of the cyclo-oxygenase inhibitor indo ... Full text Cite