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Suheil Jamil Muasher

Professor Emeritus of Obstetrics and Gynecology
Obstetrics and Gynecology, Reproductive Endocrinology & Infertility

Selected Publications


Success rates with preimplantation genetic testing for aneuploidy in good prognosis patients are dependent on age.

Journal Article Fertil Steril · September 29, 2024 OBJECTIVE: To evaluate cumulative live birth after preimplantation genetic testing for aneuploidy (PGT-A) with next generation sequencing (NGS) compared with morphology alone among patients aged 21-40 years undergoing single blastocyst transfer. DESIGN: Re ... Full text Link to item Cite

Requests for mild or natural cycle IVF treatment

Chapter · June 4, 2021 This chapter includes clinical cases, background, evidence-based practical management options, preventive measures and key-point summaries of mild or natural cycle in-vitro fertilization (IVF) treatment. IVF is the major treatment strategy of assisted repr ... Full text Cite

The Risk of Congenital Anomalies by Fertility Treatment Modality.

Journal Article Obstet Gynecol Surv · January 2021 IMPORTANCE: Up to 4% of all births in developed nations involve assisted reproductive technology (ART), along with other fertility treatment modalities. Thus, ART pregnancies constitute an important epidemiologic population with a known increased risk of c ... Full text Link to item Cite

Single blastocyst transfer yields similar pregnancy rates compared with multiple cleavage embryo transfer, with reduced twin rate, in patients with low number of fertilized oocytes

Journal Article Middle East Fertility Society Journal · December 1, 2020 Background: In patients with low numbers of embryos, there is not yet consensus on whether to extend culture to the blastocyst stage, especially due to the risk that some or all of the embryos will not make it to the blastocyst stage. The objective of our ... Full text Cite

Total follicle stimulating hormone dose is negatively correlated with live births in a donor/recipient model with fresh transfer: an analysis of 8,627 cycles from the Society for Assisted Reproductive Technology Registry.

Conference Fertil Steril · September 2020 OBJECTIVE: Oocyte donation has optimized our understanding of ovarian stimulation. Increasing the follicle-stimulating hormone (FSH) dose has been shown to adversely affect live birth rates in autologous cycles. Our objective is to assess whether this rela ... Full text Link to item Cite

Increased Risk of Aortic Dissection Associated With Pregnancy in Women With Turner Syndrome: A Systematic Review.

Journal Article Obstet Gynecol Surv · September 2020 IMPORTANCE: Turner syndrome (TS) is one of the most common chromosomal abnormalities in women. The condition is characterized by gonadal dysgenesis and is associated with structural cardiac abnormalities. Assisted reproductive technology with oocyte donati ... Full text Link to item Cite

Surrogacy Laws in the United States: What Obstetrician-Gynecologists Need to Know.

Journal Article Obstet Gynecol · March 2020 The first child carried by a surrogate after in vitro fertilization in the United States was born in 1985. Since then, the number of such births has steadily grown. According to the Centers for Disease Control and Prevention, the number of gestational carr ... Full text Link to item Cite

Patient and in vitro fertilization (IVF) cycle characteristics associated with variable blastulation rates: a retrospective study from the Duke Fertility Center (2013–2017)

Journal Article Middle East Fertility Society Journal · December 1, 2019 Background: To evaluate the association of patient and IVF cycle characteristics with blastulation rate and formation of high-quality blastocysts Results: We analyzed autologous blastocyst cycles from 2013 to 2017. Cycles were subdivided into low (< 33%), ... Full text Cite

Clinical pregnancy and live birth increase significantly with every additional blastocyst up to five and decline after that: an analysis of 16,666 first fresh single-blastocyst transfers from the Society for Assisted Reproductive Technology registry.

Journal Article Fertil Steril · November 2019 OBJECTIVE: To study the association between the number of blastocysts available and pregnancy outcomes in first fresh autologous single blastocyst transfer cycles. DESIGN: Retrospective cohort study. SETTING: Not applicable. PATIENT(S): Patients from the S ... Full text Link to item Cite

Clinical pregnancy (CP) and live birth (LB) increase significantly with each additional fertilized oocyte up to nine, and CP and LB decline after that: an analysis of 15,803 first fresh in vitro fertilization cycles from the Society for Assisted Reproductive Technology registry.

Journal Article Fertil Steril · September 2019 OBJECTIVE: To study the association between the total number of fertilized oocytes available and pregnancy outcomes in first fresh IVF cycles with a single blastocyst transfer. DESIGN: Retrospective cohort study. SETTING: Not applicable. PATIENT(S): A tota ... Full text Link to item Cite

Does a freeze-all policy lead to better IVF outcomes in first autologous cycles?

Journal Article Middle East Fertility Society Journal · December 1, 2018 Full text Cite

Freezing of all embryos in in vitro fertilization is beneficial in high responders, but not intermediate and low responders: an analysis of 82,935 cycles from the Society for Assisted Reproductive Technology registry.

Journal Article Fertil Steril · October 2018 OBJECTIVE: To assess in vitro fertilization (IVF) and pregnancy outcomes in patients having their first frozen embryo transfer (FET) after a freeze-all cycle versus similar patients having their first fresh embryo transfer (ET). DESIGN: Retrospective cohor ... Full text Link to item Cite

Do donor oocyte cycles comply with ASRM/SART embryo transfer guidelines? An analysis of 13,393 donor cycles from the SART registry.

Journal Article Fertil Steril · September 1, 2016 OBJECTIVE: To analyze donor oocyte cycles in the Society for Assisted Reproductive Technology (SART) registry to determine: 1) how many cycles complied with the 2009 American Society for Reproductive Medicine/SART embryo transfer guidelines; and 2) cycle o ... Full text Link to item Cite

How compliant are in vitro fertilization member clinics in following embryo transfer guidelines? An analysis of 59,689 fresh first in vitro fertilization autologous cycles from 2011 to 2012.

Journal Article Fertil Steril · September 1, 2016 OBJECTIVE: To determine whether IVF clinics are compliant with American Society for Reproductive Medicine (ASRM) and Society for Assisted Reproductive Technology (SART) (ASRM/SART) guidelines and assess the multiple pregnancy outcomes according to the numb ... Full text Link to item Cite

Donor oocytes are associated with preterm birth when compared to fresh autologous in vitro fertilization cycles in singleton pregnancies.

Journal Article Fertil Steril · September 1, 2016 OBJECTIVE: To use a national registry to examine the role of oocyte donation on pregnancy outcomes in singleton pregnancies. DESIGN: Retrospective cohort. SETTING: Not applicable. PATIENT(S): Women undergoing autologous cycles and donor oocyte recipients i ... Full text Link to item Cite

Spontaneous Abortion and Recurrent Pregnancy Loss

Chapter · June 22, 2016 Ltd. Cleveland, Ohio Sanaz Keyhan, MD Clinical Instructor Department of Obstetrics and Gynecology Duke University School of Medicine Durham, North Carolina Rosanne M. Kho, MD Associate Professor Director, Benign Gynecologic  ... ... Link to item Cite

Pregnancy outcomes decline with increasing body mass index: analysis of 239,127 fresh autologous in vitro fertilization cycles from the 2008-2010 Society for Assisted Reproductive Technology registry.

Journal Article Fertil Steril · March 2016 OBJECTIVE: To examine the effect of body mass index (BMI) on IVF outcomes in fresh autologous cycles. DESIGN: Retrospective cohort study. SETTING: Not applicable. PATIENT(S): A total of 239,127 fresh IVF cycles from the 2008-2010 Society for Assisted Repro ... Full text Link to item Cite

Pregnancy outcomes decline with increasing recipient body mass index: an analysis of 22,317 fresh donor/recipient cycles from the 2008-2010 Society for Assisted Reproductive Technology Clinic Outcome Reporting System registry.

Journal Article Fertil Steril · February 2016 OBJECTIVE: To examine the effect of recipient body mass index (BMI) on IVF outcomes in fresh donor oocyte cycles. DESIGN: Retrospective cohort study. SETTING: Not applicable. PATIENT(S): A total of 22,317 donor oocyte cycles from the 2008-2010 Society for ... Full text Link to item Cite

High peak estradiol/mature oocyte ratio predicts lower clinical pregnancy, ongoing pregnancy, and live birth rates in GnRH antagonist intracytoplasmic sperm injection cycles

Journal Article Journal of Reproductive Medicine · February 1, 2016 OBJECTIVE: To define the relationship between peak estradiol (E2)/mature oocyte ratio and pregnancy outcomes in gonadotropin-releasing hormone (GnRH) antagonist intracytoplasmic sperm injection (ICSI) cycles. STUDY DESIGN: Retrospective cohort study in the ... Cite

High Peak Estradiol/Mature Oocyte Ratio Predicts Lower Clinical Pregnancy, Ongoing Pregnancy, and Live Birth Rates in GnRH Antagonist Intracytoplasmic Sperm Injection Cycles.

Journal Article J Reprod Med · 2016 OBJECTIVE: To define the relationship between peak estradiol (E2)/mature oocyte ratio and pregnancy outcomes in gonadotropin-releasing hormone (GnRH) antagonist intracytoplasmic sperm injection (ICSI) cycles. STUDY DESIGN: Retrospective cohort study in the ... Link to item Cite

High peak estradiol predicts higher miscarriage and lower live birth rates in high responders triggered with a gnrh agonist in IVF/ICSI cycles

Journal Article Journal of Reproductive Medicine · December 1, 2015 OBJECTIVE: To investigate parameters predictive of pregnancy outcomes in high responders undergoing fresh, autologous, GnRH antagonist IVF/ICSI cycles using a GnRH agonist trigger. STUDY DESIGN: Retrospective cohort study of all patients deemed high-risk f ... Cite

Ectopic pregnancy rate increases with the number of retrieved oocytes in autologous in vitro fertilization with non-tubal infertility but not donor/recipient cycles: an analysis of 109,140 clinical pregnancies from the Society for Assisted Reproductive Technology registry.

Journal Article Fertil Steril · October 2015 OBJECTIVE: To study the impact of controlled ovarian stimulation on ectopic pregnancy (EP) rate as a function of the number of oocytes retrieved, using donor IVF cycles as a control. DESIGN: Retrospective cohort study using a large national database. SETTI ... Full text Link to item Cite

An Update on Surgical versus Expectant Management of Ovarian Endometriomas in Infertile Women.

Journal Article Biomed Res Int · 2015 Ovarian endometriomas are a common manifestation of endometriosis that can represent a more severe stage of the disease. There is much debate over the treatment of these cysts in infertile women, particularly before use of assisted reproductive technologie ... Full text Open Access Link to item Cite

High Peak Estradiol Predicts Higher Miscarriage and Lower Live Birth Rates in High Responders Triggered with a GnRH Agonist in IVF/ICSI Cycles.

Journal Article J Reprod Med · 2015 OBJECTIVE: To investigate parameters predictive of pregnancy outcomes in high responders undergoing fresh, autologous, GnRH antagonist IVF/ICSI cycles using a GnRH agonist trigger. STUDY DESIGN: Retrospective cohort study of all patients deemed high-risk f ... Link to item Cite

Ectopic pregnancy rates in frozen versus fresh embryo transfer in in vitro fertilization: A systematic review and meta-analysis

Journal Article Middle East Fertility Society Journal · December 1, 2014 Objective To evaluate whether the rate of ectopic pregnancy differs between fresh and frozen embryo transfers. ... Full text Cite

Pregnancy rates in donor oocyte cycles compared to similar autologous in vitro fertilization cycles: an analysis of 26,457 fresh cycles from the Society for Assisted Reproductive Technology.

Journal Article Fertil Steril · August 2014 OBJECTIVE: To use a large US IVF database and compare pregnancy outcomes in fresh donor oocyte versus autologous IVF cycles in women age 20-30 years. DESIGN: Retrospective cohort study. SETTING: Not applicable. PATIENT(S): Women undergoing fresh autologous ... Full text Link to item Cite

Pregnancy outcomes decline in recipients over age 44: an analysis of 27,959 fresh donor oocyte in vitro fertilization cycles from the Society for Assisted Reproductive Technology.

Journal Article Fertil Steril · May 2014 OBJECTIVE: To use a large and recent national registry to provide an updated report on the effect of recipient age on the outcome of donor oocyte in vitro fertilization (IVF) cycles. DESIGN: Retrospective cohort study. SETTING: United States national regis ... Full text Link to item Cite

Oocyte number as a predictor for ovarian hyperstimulation syndrome and live birth: an analysis of 256,381 in vitro fertilization cycles.

Journal Article Fertil Steril · April 2014 OBJECTIVE: To investigate the association between oocyte number and the rates of ovarian hyperstimulation syndrome (OHSS) and live birth (LB) in fresh autologous in vitro fertilization (IVF) cycles. DESIGN: Retrospective cohort study. SETTING: An academic ... Full text Link to item Cite

Leukocytospermia: Overview of diagnosis, implications, and management of a controversial finding

Journal Article Middle East Fertility Society Journal · September 1, 2013 Background The progress in assisted reproductive techniques over the last 30 years has raised interest in studying what in 1992 the World Health Organization (WHO) defined as abnormal: the presence of >1 Ă— 10 6 leukocytes/mL in a semen sample. Leukocytospe ... Full text Cite

Mullerian agenesis associated with in-utero thalidomide exposure: A case report

Journal Article Middle East Fertility Society Journal · 2013 Thalidomide is a well-known teratogen, which is experiencing resurgence as new uses are identified. Exposure is classically associated with limb deformities, such as: dysmelia, phocomelia, preaxial hypoplasia and polydactyly, in addition to visceral anomal ... Full text Open Access Cite

Requests for Mild or Natural Cycle IVF Treatment

Journal Article · March 28, 2012 The goal of ovarian stimulation for in vitro fertilization (IVF) is to recruit multiple oocytes for fertilization. The ovarian stimulation process can be a stressful experience for the patient with multiple office visits, blood draws, and ultrasounds in ad ... Full text Cite

Mild/minimal stimulation for in vitro fertilization: an old idea that needs to be revisited.

Journal Article Fertil Steril · June 30, 2011 Mild ovarian stimulation for in vitro fertilization usually refers to the use of low-dose gonadotropins in conjunction with a gonadotropin-releasing hormone (GnRH) antagonist whereas minimal stimulation refers to the use of a sequential administration of c ... Full text Link to item Cite

How to select ovarian stimulation protocols to avoid difficulties and complications

Chapter · January 1, 2010 Stimulation protocols for the purpose of in vitro fertilization (IVF) have been constantly evolving over the last three decades. The first IVF pregnancy was an ectopic pregnancy and the first IVF baby, Louise Brown, was conceived in a natural IVF cycle. Br ... Full text Cite

The art and science of embryo transfer: What information are we lacking?

Journal Article Middle East Fertility Society Journal · January 1, 2010 Full text Cite

Is there a role for laparoscopy in the diagnosis and treatment of infertility in the 21st century?

Journal Article Middle East Fertility Society Journal · January 1, 2010 Full text Cite

Fewer medications for in vitro fertilization can be better: thinking outside the box.

Journal Article Fertil Steril · October 2009 Minimal stimulation or mild stimulation protocols for in vitro fertilization offer many advantages for all patients, but especially for low and high responders. In the current practice of reducing the number of embryos transferred to a maximum of two for a ... Full text Link to item Cite

Soft versus conventional protocol for in vitro fertilization

Journal Article Middle East Fertility Society Journal · December 1, 2008 Cite

Stimulation of the high responders and strategies to prevent ovarian hyperstimulation syndrome

Journal Article Middle East Fertility Society Journal · December 1, 2008 Identification of high responder patients is essential prior to ovarian stimulation for in vitro fertilization. These patients usually yield a high number of oocytes (> 15) with high peak estradiol levels (> 3000 pg/ml). Pregnancy and implantation rates ar ... Cite

Degrees of Uncertainty-"Statistically Insignificant"

Journal Article Fertility and Sterility · October 1, 2008 Full text Cite

Choices of stimulation for low responders in IVF

Journal Article Expert Review of Obstetrics and Gynecology · July 1, 2008 Low responders present a significant challenge for IVF practitioners due to the lower chances of a pregnancy in relation to the usual high cost of treatment. The definition of low responders is not universally agreed upon and the literature is full of arti ... Full text Cite

Luteal supplementation in in vitro fertilization: more questions than answers.

Journal Article Fertil Steril · April 2008 OBJECTIVE: To update clinicians on different regimens of luteal phase supplementation in IVF-stimulated cycles and to identify areas that need further research in this subject. DESIGN: Literature review and critical analysis of published studies on luteal ... Full text Link to item Cite

Ectopic and heterotopic pregnancies following in vitro fertilization

Chapter · January 1, 2008 Introduction, Ectopic pregnancy is defined as an abnormal implantation of the conceptus in a location outside the uterine cavity. Heterotopic pregnancy is when there are concomitant intrauterine and extrauterine pregnancies (1). Ectopic pregnancy is a life ... Full text Cite

Surgical complications of in vitro fertilization

Journal Article Middle East Fertility Society Journal · November 20, 2007 The incidence of complications arising from in vitro fertilization and oocyte retrieval is relatively low. Infections, bleeding, and ovarian torsion are the main complications discussed in this review. Physicians and patients need to be aware of these comp ... Cite

Optimal stimulation protocols for in vitro fertilization.

Journal Article Fertil Steril · August 2006 OBJECTIVE: To update clinicians on different gonadotropin regimens for ovarian stimulation for IVF including the use of urinary and recombinant gonadotropins, the value of added LH to FSH in the stimulation regimen, the use of GnRH agonists and antagonists ... Full text Link to item Cite

Is it of value to treat endometriosis prior to IVF?

Journal Article Middle East Fertility Society Journal · June 2, 2006 Cite

Surviving cancer, saving fertility: The promise of cryopreservation

Journal Article Sexuality, Reproduction and Menopause · May 1, 2006 Treatment of cancer by radiation or chemotherapy need not thwart a woman's ability to have children. While most approaches to maintaining ovarian function remain experimental, embryo-and, to some extent, oocyte-cryopreservation have delivered positive resu ... Full text Cite

Randomized trial to compare the effect of recombinant human FSH (follitropin alfa) with or without recombinant human LH in women undergoing assisted reproduction treatment.

Journal Article Reprod Biomed Online · February 2004 Women undergoing intracytoplasmic sperm injection (ICSI) for male factor infertility were randomly assigned to receive ovarian stimulation in a long agonist protocol with a combination of recombinant human FSH (r-hFSH; Gonal-F) and recombinant human LH (r- ... Full text Link to item Cite

Total quality improvement in the IVF laboratory: choosing indicators of quality.

Journal Article Reprod Biomed Online · December 2003 The purpose of this paper is to describe a programme of total quality improvement (TQI) within the IVF laboratory and to provide specific examples of indicators that could be used in such a TQI programme. Although TQI is sometimes confused with quality con ... Full text Link to item Cite

Minimal ovarian hyperstimulation for in vitro fertilization using sequential clomiphene citrate and gonadotropin with or without the addition of a gonadotropin-releasing hormone antagonist.

Journal Article Fertil Steril · November 2002 OBJECTIVE: To compare the results of a minimal-stimulation protocol with those of a standard protocol used for IVF. DESIGN: Retrospective, controlled study. SETTING: University center. PATIENT(S): Fifty-five patients undergoing IVF using a minimal-stimulat ... Full text Link to item Cite

Delaying the initiation of progesterone supplementation results in decreased pregnancy rates after in vitro fertilization: a randomized, prospective study.

Journal Article Fertil Steril · December 2001 OBJECTIVE: To compare IVF outcome between two protocols for luteal phase supplementation, one beginning on day 3 after oocyte retrieval and the other beginning on day 6 after retrieval. DESIGN: Prospective, randomized study. SETTING: University-based assis ... Full text Link to item Cite

High FSH:LH ratio and low LH levels in basal cycle day 3: impact on follicular development and IVF outcome.

Journal Article J Assist Reprod Genet · September 2001 PURPOSE: To examine the impact of low basal cycle day 3 serum LH levels or a high FSH:LH ratio on IVF results. METHODS: A homogeneous group of patients was analyzed as identified by normal basal cycle of follicle stimulating hormone (FSH), Luteinizing horm ... Full text Link to item Cite

A study of the impact of fast cleaving embryos on ART outcomes.

Journal Article Fertility and Sterility · September 2001 Full text Cite

Telomerase activity in biopsied blastomeres of human day three embryos.

Journal Article Fertility and Sterility · September 2001 Full text Cite

Use of human gametes obtained from anonymous donors for the production of human embryonic stem cell lines.

Journal Article Fertil Steril · July 2001 OBJECTIVE: To investigate the use of donated gametes for the production of human embryonic stem cell lines. DESIGN: Basic research study. SETTING: Assisted Reproductive Technology (ART) program at an academic institution. PATIENT(S): Consenting oocyte and ... Full text Link to item Cite

Outcome of intracytoplasmic sperm injection in azoospermic patients: stressing the liaison between the urologist and reproductive medicine specialist.

Journal Article Urology · July 2001 OBJECTIVES: To analyze the outcome of intracytoplasmic sperm injection (ICSI) cycles in infertile couples in whom the main diagnosis of infertility was azoospermia of obstructive and nonobstructive origin. METHODS: Eighty-three consecutive ICSI cycles were ... Full text Link to item Cite

Impact of a cryopreservation program on the multiple pregnancy rate associated with assisted reproductive technologies.

Journal Article Fertil Steril · January 2001 OBJECTIVE: To determine the impact of a cryopreservation program on pregnancy rates and multiple-pregnancy rates in ART cycles. DESIGN: Retrospective study. SETTING: University teaching hospital. PATIENT(S): Women who underwent stimulation for in vitro fer ... Full text Link to item Cite

Efficacy and safety of ganirelix acetate versus leuprolide acetate in women undergoing controlled ovarian hyperstimulation.

Journal Article Fertil Steril · January 2001 OBJECTIVE: To assess the efficacy, safety, and local tolerance of ganirelix acetate for the inhibition of premature luteinizing hormone (LH) surges in women undergoing controlled ovarian hyperstimulation (COH). DESIGN: Phase III, multicenter, open-label ra ... Full text Link to item Cite

Hydrosalpinx and IVF: The role of surgical treatment

Journal Article Middle East Fertility Society Journal · January 1, 2001 Cite

Impact of different clinical variables on pregnancy outcome following embryo cryopreservation.

Journal Article Mol Cell Endocrinol · November 27, 2000 In our program's 13 years of experience, more than 9000 embryos have been cryopreserved in gonadotropin-stimulated IVF cycles. Over 1500 thaw and transfer cycles have yielded a pregnancy rate of approximately 25%. Different ovarian stimulation regimens (va ... Full text Link to item Cite

Evaluation of the clinical efficacy of embryo cryopreservation.

Journal Article Mol Cell Endocrinol · November 27, 2000 To fully evaluate the advantages of a cryopreservation program a method needs to be established to express the additional patients pregnant from cryopreservation. The patient specific method considers cryopreservation as augmentation only among patients wi ... Full text Link to item Cite

Human embryos derived from in vitro and in vivo matured oocytes: analysis for chromosomal abnormalities and nuclear morphology.

Journal Article J Assist Reprod Genet · May 2000 PURPOSE: To determine whether embryos resulting from oocytes matured in vitro have a higher incidence of nuclear and/or genetic abnormalities compared to embryos resulting from oocytes matured in vivo. METHODS: Fluorescence in situ hybridization analysis f ... Full text Link to item Cite

Is the timing of implantation affected by zona pellucida micromanipulation?

Journal Article J Assist Reprod Genet · January 2000 PURPOSE: Our purpose was to examine the timing of implantation and early embryo development following uterine transfer of oocytes/embryos previously subjected to zona pellucida micromanipulation. METHODS: A total of 68 singleton pregnancies resulting from ... Full text Link to item Cite

Embryo implantation in in vitro fertilization and intracytoplasmic sperm injection: impact of cleavage status, morphology grade, and number of embryos transferred.

Journal Article Fertil Steril · October 1999 OBJECTIVE: The aims of this study were to compare preimplantation embryo quality in intracytoplasmic sperm injection (ICSI) with standard IVF and to examine the impact of age and number and quality of embryos transferred on implantation and pregnancy. DESI ... Full text Link to item Cite

Recombinant and urinary FSH preparations: A comparative analysis of multifollicular development and IVF/ICSI outcome in different categories of ovarian responders

Journal Article Middle East Fertility Society Journal · August 19, 1999 Objectives: To compare recombinant and urinary FSH preparations in their capacity to induce ovarian multifollicular development and impact of IVF/ICSI outcome in different categories of ovarian responders. Design: Retrospective, comparative analysis. Setti ... Cite

The value of basal serum follicle stimulating hormone, luteinizing hormone and oestradiol concentrations following pituitary down-regulation in predicting ovarian response to stimulation with highly purified follicle stimulating hormone.

Journal Article Hum Reprod · May 1999 The value of gonadotrophin and oestradiol concentrations following pituitary down-regulation with leuprolide acetate in predicting ovarian response to stimulation was evaluated in three groups of women undergoing ovarian stimulation for in-vitro fertilizat ... Full text Link to item Cite

Pregnancy following transfer of ooplasm from cryopreserved-thawed donor oocytes into recipient oocytes.

Journal Article Fertil Steril · March 1999 OBJECTIVE: To determine if frozen-thawed donor oocytes could be used to provide cytoplasm for transfer into patients' oocytes to improve subsequent embryonic development. DESIGN: Prospective evaluation of the procedure in consenting IVF patients. SETTING: ... Full text Link to item Cite

Effect of hydrosalpinx on IVF outcome--mechanism?

Journal Article Fertil Steril · October 1998 Full text Link to item Cite

Effect of hydrosalpinx on IVF outcome - Mechanism? Reply

Journal Article FERTILITY AND STERILITY · October 1, 1998 Link to item Cite

Analysis of implantation in assisted reproduction through the use of serial human chorionic gonadotropin measurements.

Journal Article J Assist Reprod Genet · September 1998 PURPOSE: Our purpose was to examine implantation of singleton pregnancies achieved following various assisted reproductive technologies (ARTs) through the appearance and rising titers of serum human chorionic gonadotropin (hCG) levels. METHODS: A total of ... Full text Link to item Cite

Semen quality: is there a paternal effect on pregnancy outcome in in-vitro fertilization/intracytoplasmic sperm injection?

Journal Article Hum Reprod · August 1998 The objective of this study was to investigate the role of the spermatozoon (paternal effects) on implantation and pregnancy outcome in in-vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). Male individuals of three types were analysed: infer ... Full text Link to item Cite

Cessation of gonadotropin-releasing hormone agonist therapy combined with high-dose gonadotropin stimulation yields favorable pregnancy results in low responders.

Journal Article Fertil Steril · May 1998 OBJECTIVE: To evaluate the pregnancy results of an ovarian hyperstimulation protocol for IVF-ET that combines GnRH agonist down-regulation, cessation of GnRH agonist therapy with the onset of menstruation, and high-dose gonadotropin administration in low r ... Full text Link to item Cite

The significance of hydrosalpinx in in vitro fertilization.

Journal Article Fertil Steril · March 1998 OBJECTIVE: To review the effects of hydrosalpinx on IVF/ET and the role of salpingectomy. DESIGN: The literature on hydrosalpinx, IVF/ET, embryotoxicity, and salpingectomy for hydrosalpinx was identified through MEDLINE searches and reviewed. RESULT(S): Hy ... Full text Link to item Cite

A prospective, randomized, double-blind study for the evaluation of assisted hatching in patients with advanced maternal age.

Journal Article Hum Reprod · February 1998 The objective of this study was to determine if assisted hatching improved the rates of implantation, clinical pregnancy and ongoing pregnancy for in-vitro fertilization (IVF) patients aged > or =36 years. On the day of oocyte aspiration, consenting patien ... Full text Link to item Cite

Impact of fertilization history and semen parameters on ICSI outcome.

Journal Article J Assist Reprod Genet · January 1998 PURPOSE: The objectives of this study were (1) to investigate intracytoplasmic sperm injection (ICSI) outcome according to its indications, i.e., a history of failed or poor fertilization and unsuitable sperm parameters for conventional IVF, and (2) to exa ... Full text Link to item Cite

The outcome of clinical pregnancies following intracytoplasmic sperm injection is not affected by semen quality.

Journal Article Andrologia · 1998 The objective of this study was to investigate the impact of severe oligoasthenoteratozoospermia (OAT) on pregnancy outcome. For this purpose 279 consecutive intracytoplasmic sperm injection (i.c.s.i) cycles were retrospectively evaluated and compared to 4 ... Full text Link to item Cite

Improved oocyte quality is obtained with follicle stimulating hormone alone than with follicle stimulating hormone/human menopausal gonadotrophin combination.

Journal Article Hum Reprod · September 1997 The aim of this study was to compare the efficacy of pure follicle stimulating hormone (FSH) with that of FSH/human menopausal gonadotrophin (HMG) combination in downregulated cycles. A total of 357 patients was evaluated retrospectively. Sixty percent of ... Full text Link to item Cite

The impact of an egg donor's age and her prior fertility on recipient pregnancy outcome.

Journal Article Fertil Steril · August 1997 OBJECTIVE: To investigate the effect of donor's age and her prior fertility on recipient pregnancy outcome in our donor egg program. DESIGN: Retrospective cohort analysis. SETTING: Large academic infertility center. PATIENT(S): A total of 568 fresh ETs wer ... Full text Link to item Cite

Cryopreservation of all prezygotes in patients at risk of severe hyperstimulation does not eliminate the syndrome, but the chances of pregnancy are excellent with subsequent frozen-thaw transfers.

Journal Article Hum Reprod · July 1997 In-vitro fertilization patients (n = 15) at risk of ovarian hyperstimulation syndrome (OHSS) (oestradiol > or =4500 pg/ml on the day of human chorionic gonadotrophin administration and 25 or more follicles of intermediate or large size) underwent aspiratio ... Full text Link to item Cite

Transfer of cryopreserved-thawed pre-embryos in a cycle using exogenous steroids without prior gonadotrophin-releasing hormone agonist suppression yields favourable pregnancy results.

Journal Article Hum Reprod · June 1997 We have analysed the use of a programmed cycle of administration of exogenous steroids without prior suppression with a gonadotrophin-releasing hormone agonist (GnRHa) for the transfer of cryopreserved-thawed pre-embryos. From July 1992 to June 1994, 199 c ... Full text Link to item Cite

Progesterone levels on the day of human chorionic gonadotropin do not predict pregnancy outcome from the transfer of fresh or cryopreserved embryos from the same cohort.

Journal Article Fertil Steril · February 1997 OBJECTIVE: To analyze the differences in pregnancy rates (PRs) from the transfer of fresh and cryopreserved embryos from the same cohort of oocytes based on serum P levels on the day of hCG administration and the day after. DESIGN: Retrospective analysis. ... Full text Link to item Cite

Salpingectomy improves pregnancy rate in patients with hydrosalpinx

Journal Article HUMAN REPRODUCTION · September 1, 1996 Link to item Cite

Suppression and flare regimens of gonadotropin-releasing hormone agonist. Use in women with different basal gonadotropin values in an in vitro fertilization program.

Journal Article J Reprod Med · May 1996 OBJECTIVE: To evaluate the suppression and flare regimens of gonadotropin-releasing hormone agonist (GnRH-a) in ovarian hyperstimulation in women with variable basal gonadotropin values in an in vitro fertilization (IVF) program. STUDY DESIGN: A retrospect ... Link to item Cite

A comparative analysis of embryo implantation potential in patients with severe teratozoospermia undergoing in-vitro fertilization with a high insemination concentration or intracytoplasmic sperm injection.

Journal Article Hum Reprod · May 1996 The objective of this study was to assess fertilization, implantation and pregnancy rates in infertile patients with severe teratozoospermia [P (poor prognosis) pattern sperm morphology assessed by strict criteria] treated by in-vitro fertilization (IVF) u ... Full text Link to item Cite

Salpingectomy improves the pregnancy rate in in-vitro fertilization patients with hydrosalpinx.

Journal Article Hum Reprod · March 1996 The objective of this study was to assess the impact on pregnancy outcome of excising hydrosalpinx(ges) in patients with repeated in-vitro fertilization (IVF) failures. A group of 15 patients who had previously undergone failed IVF attempts and had unilate ... Full text Link to item Cite

The incidence of multiple gestations after in vitro fertilization is dependent on the number of embryos transferred and maternal age.

Journal Article Fertil Steril · March 1996 OBJECTIVE: To determine if the incidence of multiple gestations after IVF differs significantly depending on the number of embryos transferred and maternal age. DESIGN: Retrospective analysis of IVF database. SETTING: Tertiary care academic center. PATIENT ... Full text Link to item Cite

Intracytoplasmic sperm injection: achievement of high pregnancy rates in couples with severe male factor infertility is dependent primarily upon female and not male factors.

Journal Article Fertil Steril · November 1995 OBJECTIVE: To determine the efficacy and factors affecting outcome of intracytoplasmic sperm injection (ICSI) in patients with severe male factor infertility. DESIGN: Prospectively designed clinical trial of patients selected to participate in the study ba ... Full text Link to item Cite

Cryopreservation: the problem of evaluation.

Journal Article Hum Reprod · August 1995 A simple evaluatory formula for reporting pregnancy rates involving cryopreserved material has so far remained elusive. It is highly desirable to have a method which would allow not only an evaluation of cryotechnology per se, but also an evaluation of the ... Full text Link to item Cite

Evaluation of the spindle apparatus of in-vitro matured human oocytes following cryopreservation.

Journal Article Hum Reprod · July 1995 The present study was conducted to determine if the cryopreservation of immature human oocytes has a deleterious effect on the meiotic spindle following maturation in vitro. Oocytes were obtained in excess from in-vitro fertilization patients and divided i ... Full text Link to item Cite

High doses of gonadotropins have no detrimental effect on in vitro fertilization outcome in normal responders.

Journal Article Fertil Steril · June 1995 OBJECTIVE: To examine the effect of high doses of gonadotropins on IVF outcome in normal (intermediate) responders. DESIGN: Retrospective analysis of patients undergoing IVF therapy from 1990 to 1994 at our institution. SETTING: Academic tertiary center. P ... Full text Link to item Cite

Low-dose glucocorticoids after in vitro fertilization and embryo transfer have no significant effect on pregnancy rate.

Journal Article Fertil Steril · March 1995 OBJECTIVE: To determine the effect on pregnancy rate (PR) of low-dose glucocorticoid treatment in cycles without micromanipulation. DESIGN: Randomized, prospective, double-blinded, placebo-controlled trial. SETTING: One university-based tertiary infertilit ... Full text Link to item Cite

Clinical and laboratory aspects of cryopreservation

Journal Article Seminars in Reproductive Endocrinology · January 1, 1995 Full text Cite

Transfer of cryopreserved-thawed pre-embryos in a natural cycle or a programmed cycle with exogenous hormonal replacement yields similar pregnancy results.

Journal Article Fertil Steril · September 1994 OBJECTIVE: To examine the results of 7 years of thawed ET during natural or controlled cycles using exogenous steroids. DESIGN: Retrospective evaluation to compare implantation and pregnancy rates with two protocols for transfer of cryopreserved-thawed pre ... Full text Link to item Cite

Sperm morphology as diagnosed by strict criteria: probing the impact of teratozoospermia on fertilization rate and pregnancy outcome in a large in vitro fertilization population.

Journal Article Fertil Steril · September 1994 OBJECTIVE: To investigate the predictive value of sperm morphology assessed by strict criteria on IVF outcome. DESIGN: Retrospective analysis of all IVF cycles (January 1987 to December 1992). MAIN OUTCOME MEASURES: All patients were assigned to one of thr ... Full text Link to item Cite

Reduced pregnancy outcome in patients with unilateral or bilateral hydrosalpinx after in vitro fertilization.

Journal Article Eur J Obstet Gynecol Reprod Biol · August 1994 In a retrospective study, we compared 118 patients with hydrosalpinx and 157 patients with bilateral salpingectomy entering an established in vitro fertilisation programme between 1988 and 1992. Patients with unilateral or bilateral hydrosalpinx had a lowe ... Full text Link to item Cite

Fertilization and in vitro development of cryopreserved human prophase I oocytes.

Journal Article Fertil Steril · May 1994 OBJECTIVE: To determine the potential for in vitro maturation, fertilization, and cleavage after cryopreservation of immature, prophase I human oocytes. DESIGN: Immature oocytes obtained in excess of the number required by the patient were randomized and c ... Full text Link to item Cite

Early follicular rise of serum progesterone concentration in response to a flare-up effect of gonadotrophin-releasing hormone agonist impairs follicular recruitment for in-vitro fertilization.

Journal Article Hum Reprod · February 1994 A retrospective study of 150 cycles of in-vitro fertilization (IVF) was undertaken to determine the impact of elevated serum progesterone in the early follicular phase of IVF cycles utilizing gonadotrophin-releasing hormone agonist (GnRHa) initiated in the ... Full text Link to item Cite

Is progesterone rise in the follicular phase detrimental to pregnancy outcome in ART?

Journal Article Assisted Reproduction Reviews · January 1, 1994 Cite

Significantly enhanced pregnancy rates per cycle through cryopreservation and thaw of pronuclear stage oocytes.

Journal Article Fertil Steril · June 1993 OBJECTIVE: To examine the results of a 5-year trial using cryopreservation to limit multiple pregnancy and optimize overall pregnancy per cycle. DESIGN: Retrospective clinical evaluation of pregnancy rates (PRs) per cycle after freezing pronuclear stage hu ... Full text Link to item Cite

Basal follicle-stimulating hormone level and age affect the chance for and outcome of pre-embryo cryopreservation.

Journal Article Fertil Steril · March 1993 All IVF cycles in which subsequent transfers of thawed pre-embryos occurred were studied. Both age and basal (cycle day 3) FSH level are important determinants of the chance for cryopreservation and the performance of cryopreserved pre-embryos. Although th ... Full text Link to item Cite

Treatment of low responders.

Journal Article J Assist Reprod Genet · February 1993 Full text Link to item Cite

Prediction of fertilization in vitro with human gametes: is there a litmus test?

Journal Article Am J Obstet Gynecol · December 1992 OBJECTIVES: The objectives of this study were as follows: (1) to evaluate the relationships between sperm concentration, morphologic pattern, motion parameters, and sperm-zona pellucida binding capacity and (2) to assess their ability to predict fertilizat ... Full text Link to item Cite

Influence of number of pre-embryos transferred, progesterone level and oestradiol/progesterone ratio at thaw on pregnancy results during replacement of cryopreserved pre-embryos in natural cycles.

Journal Article Hum Reprod · July 1992 When frozen-thawed pre-embryos were transferred in a natural menstrual cycle, a clinical pregnancy rate of 22% per transfer cycle was obtained. The pregnancy rates were higher when serum progesterone levels at thaw were less than or equal to 3.4 ng/ml than ... Full text Link to item Cite

Effects of myomas or prior myomectomy on in vitro fertilization (IVF) performance.

Journal Article J Assist Reprod Genet · June 1992 OBJECTIVE: The purpose of this study was to determine the effect of the presence of myomas and prior myomectomy on the pregnancy rate and pregnancy outcome in an in vitro fertilization (IVF) program. DESIGN: Data collected from office and hospital records ... Full text Link to item Cite

Sonographic appearance of the endometrium: the predictive value for the outcome of in-vitro fertilization in stimulated cycles.

Journal Article Hum Reprod · May 1992 We evaluated the predictive value for pregnancy of the endometrial thickness and pattern assessed by vaginal sonography on the day of human chorionic gonadotrophin (HCG) injection and the day of embryo transfer in 74 stimulated cycles for in-vitro fertiliz ... Full text Link to item Cite

Embryo transfer to the uterus or the fallopian tube after in vitro fertilization yields similar results.

Journal Article Fertil Steril · May 1992 The outcome of ZIFT and IVF-ET was compared in consecutive nontubal factor patients in a prospective fashion. Groups did not differ in characteristics and were matched by the number of prezygotes/pre-embryos transferred. Overall, implantation, pregnancy, m ... Full text Link to item Cite

Significance of basal follicle-stimulating hormone levels in women with one ovary in a program of in vitro fertilization.

Journal Article Fertil Steril · April 1992 OBJECTIVE: To understand the impact of having a single ovary on basal follicle-stimulating hormone (FSH) level and its diagnostic and prognostic usefulness in in vitro fertilization (IVF). DESIGN: All IVF cases from July 1987 to June 1990 with known basal ... Full text Link to item Cite

Outcome of twin, triplet, and quadruplet in vitro fertilization pregnancies: the Norfolk experience.

Journal Article Fertil Steril · April 1992 OBJECTIVE: To review the maternal morbidity and neonatal morbidity and mortality associated with in vitro fertilization (IVF) multiple pregnancies. DESIGN: Retrospective analysis of data collected from office and hospital records and from questionnaires se ... Link to item Cite

Performance of cryopreserved pre-embryos obtained in in vitro fertilization cycles with or without a gonadotropin-releasing hormone agonist.

Journal Article Fertil Steril · March 1992 OBJECTIVE: To evaluate the viability and potential for pregnancy of cryopreserved/thawed pre-embryos obtained after ovarian stimulation using gonadotropin-releasing hormone agonist (GnRH-a) adjunct therapy. DESIGN: Retrospective clinical evaluation of all ... Full text Link to item Cite

Use of gonadotrophin-releasing hormone agonists in controlled ovarian hyperstimulation for in vitro fertilization.

Journal Article Clin Ther · 1992 The aim of ovarian hyperstimulation for in vitro fertilization (IVF) is the recruitment of multiple fertilizable healthy oocytes. Transfer of multiple embryos yields a better success rate than single-embryo transfers. Moreover, cryopreservation of excess p ... Link to item Cite

Successful fertilization and pregnancy outcome in in-vitro fertilization using cryopreserved/thawed spermatozoa from patients with malignant diseases.

Journal Article Hum Reprod · January 1992 Cryopreservation of spermatozoa before treatment is the only proven effective method available to circumvent the sterilizing effect of therapy in some patients with malignant diseases. Because of impaired sperm quality after freezing and thawing in-vitro f ... Full text Link to item Cite

The gonadotropin-releasing hormone agonist stimulation test--a sensitive predictor of performance in the flare-up in vitro fertilization cycle.

Journal Article Fertil Steril · October 1991 OBJECTIVE: To evaluate the initial versus early pattern of estradiol (E2) change after administration of a gonadotropin-releasing hormone agonist (GnRH-a), i.e., the GnRH-a stimulation test versus E2 pattern, respectively, as predictors of ovarian response ... Full text Link to item Cite

Outcome of triplet and quadruplet pregnancies resulting from in vitro fertilization.

Journal Article Eur J Obstet Gynecol Reprod Biol · September 13, 1991 Analysis of the outcome of 26 sets of triplet and five sets of quadruplet pregnancies resulting from in vitro fertilization (IVF) shows an high incidence of antenatal complications including first trimester bleeding (53.3 and 80%), premature onset of labou ... Full text Link to item Cite

Predictive value of pregnancy during original in vitro fertilization cycle on implantation and pregnancy in subsequent cryothaw cycles.

Journal Article Fertil Steril · September 1991 OBJECTIVE: To understand the homogeneity of oocyte quality within a cohort. DESIGN: All women (n = 367) that had cryopreserved pre-embryos subsequently thawed were studied. Pregnancy and implantation rates in the in vitro fertilization (IVF) and cryothaw t ... Full text Link to item Cite

Ultrasonographic appearance of the endometrium in natural and stimulated in-vitro fertilization cycles and its correlation with outcome.

Journal Article Hum Reprod · August 1991 Ultrasonographic evaluation of the endometrium in 56 IVF patients was performed prospectively. Endometrial thickness and pattern were analysed in 18 natural-cycle and 38 stimulated-cycle patients. Thickness was measured from the echogenic interface of the ... Full text Link to item Cite

Statistical scuds.

Journal Article Fertil Steril · July 1991 Full text Link to item Cite

STATISTICAL SCUDS - REPLY

Journal Article FERTILITY AND STERILITY · July 1, 1991 Link to item Cite

Recurrent failure of in vitro fertilization: role of the hemizona assay in the sequential diagnosis of specific sperm-oocyte defects.

Journal Article Am J Obstet Gynecol · May 1991 The results of predictive fertilization bioassays (hemizona assay, hamster ova-human sperm penetration assay), in vitro fertilization treatment, fertile donor cross-match tests with either sperm or oocytes, and oocyte micromanipulation for assisted fertili ... Full text Link to item Cite

Basal follicle-stimulating hormone level is a better predictor of in vitro fertilization performance than age.

Journal Article Fertil Steril · April 1991 A study of 1,478 consecutive in vitro fertilization (IVF) cycles was made to determine if basal follicle-stimulating hormone (FSH) levels and age were independent predictors of IVF performance. Regression analyses indicated independent contributions of bot ... Full text Link to item Cite

Controlled preparation of the endometrium with exogenous steroids for the transfer of frozen-thawed pre-embryos in patients with anovulatory or irregular cycles.

Journal Article Hum Reprod · March 1991 We have reported a 36% pregnancy rate (eight of 22 transfers) with the transfer of cryopreserved-thawed embryos in patients with anovulatory or irregular cycles following a protocol using pituitary suppression with leuprolide acetate after preparation of t ... Full text Link to item Cite

Analysis of ectopic pregnancies resulting from in-vitro fertilization and embryo transfer.

Journal Article Hum Reprod · March 1991 The purpose of this study was to analyse the risk factors, stimulation characteristics, site and outcome of pregnancy and future fecundity of patients who develop ectopic pregnancies after in-vitro fertilization (IVF). Of 3145 transfer cycles between Janua ... Full text Link to item Cite

Embryo quality and pregnancy rates in patients attempting pregnancy through in vitro fertilization.

Journal Article Fertil Steril · February 1991 Patients at low risk for producing abnormal gametes produce a wide range of embryo qualities that correlate well with PRs. These data may be useful in counseling patients and in reviewing treatment and laboratory protocols. ... Full text Link to item Cite

Combined impact of the number of pre-ovulatory oocytes and cryopreservation on IVF outcome.

Journal Article Hum Reprod · February 1991 Three hundred and twenty-seven consecutive in-vitro fertilization (IVF) cycles in which luteal-phase leuprolide had been given were ranked according to the number of pre-ovulatory oocytes obtained (1-5, 6-10, greater than 10). Excess pre-embryos were cryop ... Full text Link to item Cite

Endometrial receptivities after leuprolide suppression and gonadotropin stimulation: histology, steroid receptor concentrations, and implantation rates.

Journal Article Ann N Y Acad Sci · 1991 The effect of markedly supraphysiologic levels of E2 and P4 on the endometrium was assessed by examining endometrial histology, E2 and P4 receptor concentrations, and embryo implantation rates in IVF cycles with and without leuprolide use. Results suggest ... Full text Link to item Cite

In vitro fertilization: effective alternative to surgery for distal tubal occlusion.

Journal Article Va Med Q · 1991 A total of 512 consecutive patients with tubal infertility underwent ovarian hyperstimulation for the purpose of IVF-ET, resulting in a total of 829 attempts and 890 transfers (fresh and cryo). Overall, 218 clinical pregnancies were achieved, of which 114 ... Link to item Cite

Alterations in luteal phase progesterone and estradiol production after leuprolide acetate therapy before ovarian stimulation for in vitro fertilization.

Journal Article Fertil Steril · January 1991 The impact of pituitary suppression with a gonadotropin-releasing hormone agonist (GnRH-a) on the luteal phase of in vitro fertilization (IVF) cycles was examined in 21 women who underwent identical stimulation regimens with and without leuprolide acetate ... Full text Link to item Cite

Trans-Atlantic in vitro fertilization cold war (Reply)

Journal Article Fertility and Sterility · January 1, 1991 Cite

Progesterone levels on the day of human chorionic gonadotropin administration in cycles with gonadotropin-releasing hormone agonist suppression are not predictive of pregnancy outcome.

Journal Article Fertil Steril · November 1990 In in vitro fertilization (IVF) cycles using gonadotropin-releasing hormone agonist (GnRH-a) suppression, we investigated whether an elevated progesterone (P) level on the day of human chorionic gonadotropin (hCG) administration indicates premature luteini ... Full text Link to item Cite

Implantation and pregnancy rates in relation to oestradiol and progesterone profiles in cycles with and without the use of gonadotrophin-releasing hormone agonist suppression.

Journal Article Hum Reprod · November 1990 The oestradiol (E2), progesterone (P4) levels, the corresponding E2/P4 ratios and pregnancy and implantation rates were studied in 565 in-vitro fertilization (IVF) cycles stimulated with gonadotrophins alone and in 320 cycles stimulated with adjunctive tre ... Full text Link to item Cite

The prevalence of human immunodeficiency virus in patients and their spouses entering a large in vitro fertilization program.

Journal Article J In Vitro Fert Embryo Transf · October 1990 Between September 1987 and August 1989, all patients and their spouses entering our in vitro fertilization (IVF) program were screened for the human immunodeficiency virus (HIV) using the enzyme-linked immunosorbent assay (ELISA). Of 848 patients and 848 s ... Full text Link to item Cite

Ovarian stimulation for in vitro fertilization in low-responder patients using pulsatile intravenous follicle stimulating hormone.

Journal Article J In Vitro Fert Embryo Transf · October 1990 There is a subset of patients who fail to respond adequately to exogenous gonadotropin stimulation for in vitro fertilization (IVF). In this study, six such low-responder patients who had inadequate stimulations with high-dose intramuscular (im) follicle s ... Full text Link to item Cite

Are implantation and pregnancy outcome impaired in diethylstilbestrol-exposed women after in vitro fertilization and embryo transfer?

Journal Article Fertil Steril · August 1990 Forty-six infertile women with a history of diethylstilbestrol (DES) exposure in utero underwent 149 stimulation attempts for in vitro fertilization (IVF). The mean (+/- SE) number of preovulatory oocytes harvested at retrieval and transferred was 3.9 +/- ... Full text Link to item Cite

Intercycle variability of day 3 follicle-stimulating hormone levels and its effect on stimulation quality in in vitro fertilization.

Journal Article Fertil Steril · August 1990 Prior studies have demonstrated that gonadotropin stimulation quality and pregnancy rates are better in in vitro fertilization (IVF) patients with low basal cycle day 3 follicle-stimulating hormone (FSH) levels. The records of 81 patients who had undergone ... Full text Link to item Cite

Ovarian stimulation for in vitro fertilization using pure follicle-stimulating hormone with and without gonadotropin-releasing hormone agonist in high-responder patients.

Journal Article J In Vitro Fert Embryo Transf · June 1990 There is a distinct pattern of response to gonadotropin stimulation in some patients marked by high peak estradiol (E2) levels, multifollicular ovarian response, and elevated basal luteinizing hormone (LH)/follicle-stimulating hormone (FSH) ratios. We revi ... Full text Link to item Cite

Non-functional ovarian cysts do not affect ipsilateral or contralateral ovarian performance during in-vitro fertilization.

Journal Article Hum Reprod · May 1990 Reports on the significance of ovarian cystic structures during in-vitro fertilization (IVF) have been conflicting. This study examined the effect of such structures on ovarian performance during IVF. Twenty-one patients with one or more cystic structures ... Full text Link to item Cite

Gonadotropin stimulation for in vitro fertilization and embryo transfer in insulin-dependent diabetics: follicular response, oocyte quality, embryo development, and follicular environment.

Journal Article Fertil Steril · April 1990 Two IDD patients were stimulated with gonadotropins for IVF and ET. Both patients had high E2 response and greater than or equal to 5 preovulatory oocytes retrieved, normal fertilization and cleavage rates, and transfer; neither conceived. Follicular fluid ... Full text Link to item Cite

Preclinical abortions: incidence and significance in the Norfolk in vitro fertilization program.

Journal Article Fertil Steril · April 1990 Clinical and prognostic significance of preclinical abortions in assisted reproduction is ill defined. Strict diagnostic criteria include a transient and synchronous elevation of serum beta-human chorionic gonadotropin (hCG), estradiol, and progesterone le ... Full text Link to item Cite

Survival of the cornual pregnancy in a heterotopic gestation after in vitro fertilization and embryo transfer.

Journal Article Fertil Steril · April 1990 We present a case of combined intrauterine and cornual (interstitial) pregnancy after IVF-ET, with survival of the infant after the cornual pregnancy. The diagnosis of this rare phenomenon is difficult; a high index of suspicion and frequently ultrasound m ... Full text Link to item Cite

High-dose follicle-stimulating hormone stimulation at the onset of the menstrual cycle does not improve the in vitro fertilization outcome in low-responder patients.

Journal Article Fertil Steril · March 1990 In an attempt to improve their outcome with in vitro fertilization (IVF), 34 low-responder patients were stimulated with six ampules of follicle-stimulating hormone (FSH) daily starting on day 1 (n = 17) or day 2 (n = 17) of their menstrual cycles. The sti ... Full text Link to item Cite

Equivalency of human menopausal gonadotropin and follicle-stimulating hormone stimulation after gonadotropin-releasing hormone agonist suppression.

Journal Article Fertil Steril · January 1990 This study compares the use of human menopausal gonadotropin (hMG) versus follicle-stimulating hormone (FSH), after gonadotropin-releasing hormone agonist (GnRH-a) suppression for in vitro fertilization. Thirty-seven patients were randomized to ovarian sti ... Full text Link to item Cite

IS THERE A BEST STIMULATION PROTOCOL

Conference ADVANCES IN ASSISTED REPRODUCTIVE TECHNOLOGIES · January 1, 1990 Link to item Cite

Single- and double-lumen needles for oocyte harvesting.

Journal Article J In Vitro Fert Embryo Transf · December 1989 Full text Link to item Cite

Response to the letter by Reeves (reply I)

Journal Article Journal of In Vitro Fertilization and Embryo Transfer · December 1, 1989 Cite

Delayed fertilization during in vitro fertilization and embryo transfer cycles: analysis of causes and impact on overall results.

Journal Article Fertil Steril · December 1989 This study evaluated possible causes of delayed fertilization during in vitro fertilization (IVF) cycles, its repetitiveness, and its influence on IVF results in 23 patients (27 cycles) with delayed fertilization of greater than or equal to 1 preovulatory ... Full text Link to item Cite

Impact of leuprolide acetate on the response to follicular stimulation for in vitro fertilization in patients with normal basal gonadotropin levels.

Journal Article J In Vitro Fert Embryo Transf · October 1989 Fifteen women with normal basal gonadotropin levels and adequate responses to conventional gonadotropin stimulation for in vitro fertilization (IVF) were pretreated with leuprolide acetate (LA) beginning in the midluteal phase prior to a repeat IVF attempt ... Full text Link to item Cite

Freezing techniques and results.

Journal Article Curr Opin Obstet Gynecol · October 1989 Link to item Cite

High-dose follicle-stimulating hormone (FSH) ovarian stimulation in low-responder patients for in vitro fertilization.

Journal Article J In Vitro Fert Embryo Transf · October 1989 Follicle-stimulating hormone (FSH) was used in high doses (6 ampoules/day:6FSH) for ovarian hyperstimulation for in vitro fertilization in women with a previous poor response to stimulation with the equivalent of "4FSH." Luteinizing hormone levels did not ... Full text Link to item Cite

The incidence of transient hyperprolactinemia in gonadotropin-stimulated cycles for in vitro fertilization and its effect on pregnancy outcome.

Journal Article Fertil Steril · October 1989 The incidence of transient hyperprolactinemia and its impact on in vitro fertilization (IVF) were determined in 151 euprolactinemic women with tubal infertility undergoing an identical gonadotropin stimulation for IVF. Prolactin (PRL) levels were measured ... Full text Link to item Cite

Gonadotropin stimulation protocols in the Norfolk IVF program--1988.

Journal Article J Steroid Biochem · October 1989 A standard FSH/hMG stimulation protocol applied to all patients does not yield optimum results. In the Norfolk program it has been found that the determination of FSH/LH ratio on day 3 of the menstrual cycle provides a predictive signal of the likelihood o ... Full text Link to item Cite

GnRH Agonists and IVF—Controls?

Journal Article Fertility and Sterility · September 1989 Full text Cite

In-vitro fertilization and embryo transfer in patients with endometriosis: impact of a gonadotrophin releasing hormone agonist.

Journal Article Hum Reprod · July 1989 In this study, in-vitro fertilization (IVF) cycles were examined in patients with endometriosis who received gonadotrophin releasing hormone agonist (GnRHa) therapy in an effort to improve their response to stimulation. Twelve patients treated with an iden ... Full text Link to item Cite

Comparison between laparoscopically and ultrasonographically guided transvaginal follicular aspiration methods in an in vitro fertilization program in the same patients using the same stimulation protocol.

Journal Article J In Vitro Fert Embryo Transf · June 1989 Oocyte recovery from 43 patients undergoing ultrasound-guided transvaginal oocyte retrieval was compared to a previous laparoscopic oocyte retrieval cycle from the same patient. Gonadotropin stimulation in both cycles was performed using the same protocol. ... Full text Link to item Cite

Follicle-stimulating hormone levels on cycle day 3 are predictive of in vitro fertilization outcome.

Journal Article Fertil Steril · April 1989 Cycle day 3 basal levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) were measured in 441 patients in 758 consecutive cycles to determine their predictive value for stimulation quality and pregnancy rates in vitro fe ... Full text Link to item Cite

A prospective randomized comparison of single- and double-lumen needles for transvaginal follicular aspiration.

Journal Article J In Vitro Fert Embryo Transf · April 1989 Patients undergoing ultrasound-directed transvaginal follicular aspiration in a large in vitro fertilization (IVF) program were randomized for retrieval with either a single-lumen needle (SLN; N = 22) or a double-lumen needle (DLN; N = 22) to compare recov ... Full text Link to item Cite

Correlation of follicular diameter with oocyte recovery and maturity at the time of transvaginal follicular aspiration.

Journal Article J In Vitro Fert Embryo Transf · April 1989 Forty-four consecutive patients undergoing transvaginal follicular aspiration for in vitro fertilization underwent ultrasonic measurement of follicular diameter at the time of oocyte retrieval to determine the correlation of follicular size with recovery r ... Full text Link to item Cite

Value of suppression with a gonadotropin-releasing hormone agonist prior to gonadotropin stimulation for in vitro fertilization.

Journal Article Fertil Steril · February 1989 This study examined the use of gonadotropin-releasing hormone agonist (GnRHa) suppression before gonadotropin stimulation in 26 patients with failed prior in vitro fertilization (IVF) attempts and variable basal serum gonadotropin levels. Leuprolide, 1 mg ... Full text Link to item Cite

Effects of the severity of tubo-ovarian disease and previous tubal surgery on the results of in vitro fertilization and embryo transfer.

Journal Article Fertil Steril · January 1989 The purpose of this study was to evaluate the ovarian response and in vitro fertilization/embryo transfer (IVF-ET) results in patients with tubal infertility and two ovaries, according to (1) the degree and extent of pelvic disease (isolated tubal or tubo- ... Full text Link to item Cite

Implantation potential of each pre-embryo in multiple pregnancies obtained by in vitro fertilization seems to be different.

Journal Article Fertil Steril · December 1988 Endometrial receptivity and pre-embryo quality are the main factors determining embryo implantation in in vitro fertilization. If one embryo implants normally and goes to term, the endometrium can be assumed to be normal. Eighty-one patients (March 1981 to ... Full text Link to item Cite

Follicular atresia associated with concurrent initiation of gonadotropin-releasing hormone agonist and follicle-stimulating hormone for oocyte recruitment.

Journal Article Fertil Steril · December 1988 The ability of gonadotropin-releasing hormone agonist (GnRHa) to cause an initial stimulation of serum gonadotropins was used for follicular recruitment for in vitro fertilization (IVF) in 12 patients with a history of low estradiol (E2) response to conven ... Full text Link to item Cite

In vitro fertilization and embryo transfer (IVF/ET): an established and successful therapy for endometriosis.

Journal Article J In Vitro Fert Embryo Transf · October 1988 The purpose of this report is to present a 6-year experience in the management of endometriosis with in vitro fertilization and embryo transfer (IVF/ET). We divided 136 patients who underwent 280 cycles into three groups: (1) previous history of endometrio ... Full text Link to item Cite

Timing of oocyte retrieval in cycles with a spontaneous luteinizing hormone surge in a large in vitro fertilization program.

Journal Article Fertil Steril · September 1988 Forty-four cycles with a spontaneous luteinizing hormone (LH) surge among 377 in vitro fertilization (IVF) patients were studied for outcome with different timing of oocyte retrieval. Mean number of preovulatory oocytes per retrieval and per transfer was s ... Full text Link to item Cite

The value of basal and/or stimulated serum gonadotropin levels in prediction of stimulation response and in vitro fertilization outcome.

Journal Article Fertil Steril · August 1988 The purpose of this study was to determine whether basal or stimulated (or both) serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) on day 3 of the cycle before administration of exogenous gonadotropins can predict stimulation response a ... Full text Link to item Cite

Monitoring gonadotropin-stimulated cycles for in vitro fertilization and embryo transfer.

Journal Article J In Vitro Fert Embryo Transf · August 1988 One hundred fifty-one cycles stimulated with human menopausal gonadotropin (hMG) and/or follicle-stimulating hormone (FSH) were analyzed retrospectively to determine the relationship of the monitoring parameters used: serum estradiol (E2), transvaginal son ... Full text Link to item Cite

Beta-human chorionic gonadotropin as a monitor of pregnancy outcome in in vitro fertilization-embryo transfer patients.

Journal Article Fertil Steril · July 1988 Serum human chorionic gonadotropin (hCG) was studied to test its predictability of pregnancy outcome in in vitro fertilization (IVF) patients. The mean +/- standard deviation of serum hCG concentration related to the day complete clearance of exogenous hCG ... Full text Link to item Cite

The value of in vitro fertilization for the treatment of unexplained infertility.

Journal Article Fertil Steril · May 1988 In 54 patients referred with the diagnosis of unexplained infertility (UI), the diagnosis was confirmed in 26 (strict UI) (48%). Minimal abnormalities (MA) were found in 19 (35%); 9 (17%) had gross abnormalities and were excluded from analysis. Fifty patie ... Full text Link to item Cite

Oocyte donation. The Norfolk Program.

Journal Article Ann N Y Acad Sci · 1988 Full text Link to item Cite

Results of in vitro fertilization attempts in patients with one or two ovaries.

Journal Article Fertil Steril · May 1987 The purpose of this communication is to evaluate the results of in vitro fertilization attempts in women with infertility due to a tubal factor, with one or two ovaries. Four hundred fifteen patients (788 cycles) with two ovaries and 86 patients (162 cycle ... Full text Link to item Cite

Results of in vitro fertilization attempts in women 40 years of age and older: the Norfolk experience.

Journal Article Fertil Steril · January 1987 Twenty-nine patients 40 years of age or older were stimulated with gonadotropins, starting on day 3 of the cycle, in a total of 64 cycles (January 1983 to June 1985) for multiple follicular development for in vitro fertilization. Most patients' infertility ... Full text Link to item Cite

The perimenopausal patient in in vitro fertilization: the use of gonadotropin-releasing hormone.

Journal Article Fertil Steril · November 1986 The perimenopause, incipient ovarian failure, is a major problem in stimulation failures during an in vitro fertilization program. This must be recognized as not necessarily related to age but also associated with adnexal inflammatory and operative process ... Full text Link to item Cite

An analysis of the obstetric outcome of 125 consecutive pregnancies conceived in vitro and resulting in 100 deliveries.

Journal Article Am J Obstet Gynecol · April 1986 One hundred twenty-five consecutive pregnancies conceived in vitro resulted in 100 deliveries of 115 babies. There were 23 clinical abortions (18.4%) and two tubal pregnancies. During the same interval 30 preclinical pregnancies occurred, but these pregnan ... Full text Link to item Cite

The indications for in vitro fertilization.

Journal Article Va Med · April 1986 Link to item Cite

The combination of follicle-stimulating hormone and human menopausal gonadotropin for the induction of multiple follicular maturation for in vitro fertilization.

Journal Article Fertil Steril · July 1985 One hundred fifty-one cycles in 134 consecutive patients were stimulated with 150 IU of human urinary follicle-stimulating hormone (FSH) and 150 IU of human menopausal gonadotropin (hMG) on cycle days 3 and 4 and then with 150 IU of hMG daily for the purpo ... Full text Link to item Cite

Wedge metroplasty for the septate uterus: an update.

Journal Article Fertil Steril · October 1984 Twenty-one patients with septate uteri and 2 patients with a T-shaped uterine anomaly and recurrent abortions underwent wedge metroplasty during the period from September 1978 to August 1983. Thirteen patients had a characteristic history of one or more ab ... Full text Link to item Cite

Experience with diethylstilbestrol-exposed infertile women in a program of in vitro fertilization.

Journal Article Fertil Steril · July 1984 Twenty infertile women with a history of diethylstilbestrol exposure in utero were seen in Norfolk for the purpose of in vitro fertilization. Seventeen patients had undergone 25 stimulated cycles with harvest of oocytes by laparoscopy. The serum estradiol ... Full text Link to item Cite

Luteal phase serum estradiol and progesterone in in vitro fertilization.

Journal Article Fertil Steril · June 1984 One hundred seventy-five cycles in patients with irreparable tubal disease were stimulated by human menopausal gonadotropin/human chorionic gonadotropin for the purpose of in vitro fertilization. The pregnancy rate was found to be related to the height and ... Full text Link to item Cite

Turner phenotype in mother and daughter.

Journal Article Obstet Gynecol · December 1980 Two females are described, mother and daughter, who had the Turner phenotype and spontaneous sexual development. The mother is short and had ovulatory menstrual cycles, normal breast development, X-chromatin negative buccal smear, 45,X chromosomal pattern ... Link to item Cite