Scholars@Duke
Theodore N. Pappas

Theodore N. Pappas

Duke Surgical Innovation Distinguished Professorship
Surgery, Minimally Invasive Surgery
theodore.pappas@duke.edu
Box 3479 Med Ctr, Durham, NC
1131 Hosp South, Yellow Zone, Durham, NC 27710

Selected Publications

Nephrolithiasis on the National Stage: The Kidney Stones of President Lyndon B. Johnson.

Journal Article Urology · September 16, 2024 Lyndon Baines Johnson, the 36th president of the United States, was troubled with kidney stones for most of his adult life. Three times during his political career, he required either endoscopic or open surgical removal of stones. This review will highligh ... Full text Link to item Cite

The last days of Daniel Webster: A detailed analysis of his cause of death.

Journal Article J Med Biogr · August 25, 2024 Daniel Webster (1782-1852) was one of the most impactful United States political figures of the early and mid-nineteenth century. He served in Congress and as the Secretary of State for three Presidents. He died in October of 1852 and his autopsy appeared ... Full text Link to item Cite

Ivor Lewis Esophagectomy and the Care of Humphrey Bogart's Midesophageal Cancer.

Journal Article Ann Thorac Surg · August 2024 In 1945, the Welsh surgeon Ivor Lewis first reported performing the resection of a midesophageal tumor through a combined approach involving the abdomen and right chest. Although his technique was initially rebuffed by the preeminent esophageal surgeons of ... Full text Link to item Cite

Routine Imaging Is Not Needed for Groin Hernia Diagnosis.

Journal Article Am Fam Physician · August 2024 Link to item Cite

Forensic Analysis of the Abraham Lincoln Assassination: An On-Site Study of the Presidential Box at Ford's Theatre.

Journal Article Am J Forensic Med Pathol · June 1, 2024 On April 14, 1865, Abraham Lincoln was assassinated while watching a play from the Presidential Box at Ford's Theatre in Washington, DC. There is still controversy concerning the findings of Lincoln's autopsy. The physicians that attended the autopsy docum ... Full text Link to item Cite

What is Valentino's syndrome?

Journal Article Surgical Practice · February 1, 2024 The eponym ‘Valentino's syndrome’ is used to describe patients with perforated peptic ulcer disease who present with right lower quadrant pain and suspected appendicitis. It is named for Rudolph Valentino, the film star who died on 23 August 1926 at the ag ... Full text Cite

Richard Nixon's Left Knee and Its Impact on American History.

Journal Article Am Surg · December 2023 Richard Nixon injured his left knee in a limousine door while campaigning in North Carolina in 1960, resulting in septic arthritis that required a multi-day admission to Walter Reed Hospital. Still ill for the first presidential debate that fall, Nixon los ... Full text Link to item Cite

"The President's Syndrome": The Diagnosis and Treatment of Gerald Ford's Lingual Actinomycosis.

Journal Article Am Surg · November 2023 Gerald R. Ford was the 38th president of the United States. He was appointed as vice president by Richard Nixon in 1974 upon the resignation of Spiro T. Agnew. In the midst of the Watergate Crisis, Nixon resigned making Ford the only president to serve wit ... Full text Link to item Cite

A mixed-methods study to define Textbook Outcome for the treatment of patients with uncomplicated symptomatic gallstone disease with hospital variation analyses in Dutch trial data.

Journal Article HPB (Oxford) · September 2023 BACKGROUND: International consensus on the ideal outcome for treatment of uncomplicated symptomatic gallstone disease is absent. This mixed-method study defined a Textbook Outcome (TO) for this large group of patients. METHODS: First, expert meetings were ... Full text Link to item Cite

A "New" Nonmesh Technique for Inguinal Hernia Repair: Revisiting E. Wyllys Andrews and His Imbricating Operation.

Journal Article Ann Surg Open · September 2023 The use of prosthetic mesh to repair inguinal hernias has been common practice at surgical centers around the world for more than 30 years. Open tissue repairs are the alternative for patients who cannot have, do not want, or are not offered mesh. Open tis ... Full text Link to item Cite

Medicine and History: a Surgical Model for National Integration.

Journal Article J Hist Med Allied Sci · March 23, 2023 Historians and physicians have struggled to incorporate history into American medical education for over a century. Most efforts focus on local initiatives targeting a narrow audience. We describe a novel method involving the American College of Surgeons, ... Full text Link to item Cite

The First 40 Years of Gastrojejunostomy: From Billroth to Murphy to Mayo.

Journal Article Ann Surg Open · September 2022 In the early era of therapeutic laparotomy, surgeons developed operations where the extirpation of pathology only required simple ligation of blood supply, detachment of diseased organs or drainage of infection. In 1881, when sutured anastomosis was in its ... Full text Link to item Cite

Harry Truman's Complicated Cholecystectomy.

Journal Article Ann Surg Open · March 2022 Harry S. Truman, the 33rd President of the United States, developed right-sided abdominal pain the year after he left office. Misdiagnosed with appendicitis, Truman underwent an appendectomy before a cholecystectomy treated the underlying cholecystitis. Th ... Full text Link to item Cite

Stricken Before Election: Presidential Health Crises From 1880 to 2020.

Journal Article Ann Surg Open · March 2022 Between 1880 and today, 6 presidents have suffered major health crises just before their reelection campaigns. Ranging from Chester Arthur's development of Bright's Disease to Donald Trump contracting COVID-19, diseases and their treatments varied consider ... Full text Link to item Cite

The Assassination of Medgar Evers.

Journal Article Ann Thorac Surg · January 2022 In 1995, Dr Martin Dalton published a recounting of his involvement with the first human lung transplant in the Annals of Thoracic Surgery. As recalled in that account, the first lung transplant took place in the summer of 1963 in the context of another hi ... Full text Link to item Cite

Influence of peritoneal dialysis catheter type on complications and long-term outcomes: an updated systematic review and meta-analysis.

Journal Article J Nephrol · December 2021 BACKGROUND: There is currently no consensus regarding the optimal type of peritoneal dialysis catheter (PDC). We compared the outcomes of PDCs according to the number of cuffs, intercuff and intraperitoneal segment shape, and presence of a weighted tip. ME ... Full text Link to item Cite

Diagnosis and Management of Acute Appendicitis in Adults: A Review.

Journal Article JAMA · December 2021 ImportanceAcute appendicitis is the most common abdominal surgical emergency in the world, with an annual incidence of 96.5 to 100 cases per 100 000 adults.ObservationsThe clinical diagnosis of acute appendicitis is based on history and p ... Full text Cite

Surgical versus percutaneous catheter placement for peritoneal dialysis: an updated systematic review and meta-analysis.

Journal Article J Nephrol · October 2021 BACKGROUND: No consensus currently exists regarding the optimal approach for peritoneal dialysis catheter placement. We aimed to compare the outcomes of percutaneous and surgical peritoneal dialysis catheter placement. METHODS: A systematic review of the l ... Full text Link to item Cite

The Final Illness of Herbert Hoover.

Journal Article Am Surg · April 2021 Herbert Hoover, the archetypal self-made man, was the 31st president of the United States. His term in office was overwhelmed by the Great Depression and he was defeated by Franklin Delano Roosevelt in the 1932 November presidential election. His post-pres ... Full text Link to item Cite

The Legacy of Joseph A. Moylan, M.D.: "It's About Everyone Else".

Journal Article Ann Surg Open · March 2021 The history of modern American surgery is marked by larger-than-life pioneers who have made transformative contributions to our field. These extraordinary individuals have been known primarily for their technical and clinical mastery, development of novel ... Full text Link to item Cite

Bottoms Up: A History of Rectal Nutrition From 1870 to 1920.

Journal Article Ann Surg Open · March 2021 From the 1870s through the early 20th century, physicians frequently relied upon nutritive enemata to succor patients suffering from bowel obstructions and other disorders of the gastrointestinal system. Far from extraordinary or outlandish, this therapy w ... Full text Link to item Cite

President Warren G. Harding and the 5 Doctors Who Managed His Final Illness.

Journal Article Ann Surg Open · December 2020 Warren G. Harding was elected president of the United States in 1920 and died before he finished his third year in office. Early in 1923, he had progressive weakness, shortness of breath, and chest pain. In July of 1923, while on a western trip, he develop ... Full text Link to item Cite

John Foster Dulles, his medical history and its impact on Cold War politics.

Journal Article J Med Biogr · November 2020 John Foster Dulles was the United States Secretary of State during the administration of President Dwight D Eisenhower. At the height of the Cold War, Dulles was Eisenhower's emissary, traveling over 450,000 international miles, leading United States forei ... Full text Link to item Cite

The Oswald injury.

Journal Article J Trauma Acute Care Surg · November 2020 On November 22, 1963, John F. Kennedy, the 35th president of the United States, was assassinated in Dallas, Texas. John B. Connally, the Governor of Texas, simultaneously was injured in the shooting. Both Kennedy and Connally were transported to and cared ... Full text Link to item Cite

The Assassination of Anton Cermak, Mayor of Chicago: A Review of His Postinjury Medical Care.

Journal Article Surg J (N Y) · April 2020 Anton Cermak was the mayor of Chicago in the 1930s. He was injured by an assassin's bullet intended for the president-elect, Franklin Delano Roosevelt. Cermak was taken to a local hospital, treated nonoperatively for his injuries, and initially improved. C ... Full text Link to item Cite

Surgical management of peptic ulcer disease.

Journal Article Curr Probl Surg · February 2020 Full text Link to item Cite

In Brief

Journal Article Current Problems in Surgery · February 1, 2020 Full text Cite

Maxillary Prosthetics, Speech Impairment, and Presidential Politics: How Grover Cleveland Was Able to Speak Normally after His "Secret" Operation.

Journal Article Surg J (N Y) · January 2020 In the summer of 1893, President Grover Cleveland discovered a mass on the roof of his mouth. Two physicians examined it, determined that it was a neoplasm, and recommended resection. In an effort to avoid revealing the illness to the public, the President ... Full text Link to item Cite

Prevalence and Cost Analysis of Chronic Pain After Hernia Repair: A Potential Alternative Approach With Neurostimulation.

Journal Article Neuromodulation · December 2019 OBJECTIVES: Chronic pain (CP) affects a significant number of patients following hernia repair, ranging from 11 to 54% in the literature. The aim of this study was to assess the prevalence, overall costs, and health care utilization associated with CP afte ... Full text Link to item Cite

An analysis of the vascular injuries and attempted resuscitation surrounding the assassination of Martin Luther King Jr.

Journal Article J Vasc Surg · November 2019 Martin Luther King Jr was the most prominent civil rights leader in the United States in the 1960s. He was shot by an assassin in Memphis, Tennessee, on April 4, 1968. After the shooting he was taken to a local hospital where he had an unsuccessful resusci ... Full text Link to item Cite

The assassination of Robert F. Kennedy: an analysis of the senator's injuries and neurosurgical care.

Journal Article J Neurosurg · May 1, 2019 On June 5, 1968, having won the Democratic Party presidential primary in California, Senator Robert F. Kennedy delivered a victory speech to supporters at the Ambassador Hotel in downtown Los Angeles. Just after 12:15 am (Pacific daylight savings time), a ... Full text Link to item Cite

The Role of the American Board of Surgery in the Development of Surgical Residencies in Post-World War II America.

Journal Article Am Surg · March 1, 2019 The creation of Boards fundamentally altered the American medical landscape and transformed the process of educating physicians. The American Board of Surgery, founded in 1937, epitomized this role. It established expectations, implemented an inspection sy ... Link to item Cite

Operative Management of Cholecystitis and Cholelithiasis

Chapter · January 1, 2019 With an annual rate of greater than a quarter of a million hospital admissions and an associated cost of greater than two billion dollars, cholelithiasis and cholecystitis have a tremendous impact on the health care system. Their diagnosis and associated s ... Full text Cite

Senhance Surgical System: Robotic-Assisted Digital Laparoscopy for Abdominal, Pelvic, and Thoracoscopic Procedures

Chapter · January 1, 2019 Robotic-assisted digital laparoscopy (Senhance Surgical System) provides a digitized interface between the surgeon and the patient designed to increase surgeon control and reduce surgical variability. The physical open architecture of the system is compose ... Full text Cite

The life, times, and health care of Harry L Hopkins: Presidential advisor and perpetual patient.

Journal Article J Med Biogr · February 2018 Harry Hopkins was the most important nontitled allied leader in World War II. He was the advisor to President Roosevelt who managed the diplomacy between Roosevelt, Churchill, and Stalin from 1941 to 1946. Throughout these times, Hopkins was ill and requir ... Full text Link to item Cite

A Review of Empathy, Its Importance, and Its Teaching in Surgical Training.

Journal Article J Surg Educ · 2018 BACKGROUND: There has been much discussion in the medical literature about the importance of empathy and physician communication style in medical practice. Empathy has been shown to have a very real positive effect on patient outcomes. Most of the existing ... Full text Link to item Cite

Selective and nonselective vagotomies

Chapter · January 1, 2018 Cite

Heroic Measures for an American Hero: Attempting to Save the Life of General Douglas MacArthur.

Journal Article Am Surg · December 1, 2017 General Douglas MacArthur was a towering public figure on an international stage for the first half of the 20th century. He was healthy throughout his life but developed a series of medical problems when he entered his 80s. This article reviews the General ... Link to item Cite

Bright's Disease, Malaria, and Machine Politics: The Story of the Illness of President Chester A. Arthur.

Journal Article Surg J (N Y) · October 2017 In July of 1881, President James A. Garfield was shot in the back at the Sixth Street Train Station in Washington, D.C. Garfield died after an extended illness and Chester A. Arthur assumed the presidency on September 20, 1881. He served the remaining thre ... Full text Link to item Cite

Subtotal cholecystectomy for the hostile gallbladder: failure to control the cystic duct results in significant morbidity.

Journal Article HPB (Oxford) · June 2017 BACKGROUND: Outcomes following the inability to control the cystic duct due to a hostile triangle of Calot during cholecystectomy remain unknown. The purpose of this study was to analyze the safety and efficacy of subtotal cholecystectomy, with attention t ... Full text Link to item Cite

Defining a Hospital Volume Threshold for Minimally Invasive Pancreaticoduodenectomy in the United States.

Conference JAMA Surg · April 1, 2017 IMPORTANCE: There is increasing interest in expanding use of minimally invasive pancreaticoduodenectomy (MIPD). This procedure is complex, with data suggesting a significant association between hospital volume and outcomes. OBJECTIVE: To determine whether ... Full text Link to item Cite

Non-Whipple Operations in the Management of Benign, Premalignant and Early Cancerous Duodenal Lesions.

Journal Article Anticancer Res · March 2017 AIM: We reviewed our 20-year experience with non-Whipple operations (pancreas-preserving duodenectomy and transduodenal ampullectomy) for the treatment of benign, premalignant or early-stage malignant duodenal lesions. PATIENTS AND METHODS: Twenty-four pat ... Full text Link to item Cite

Which Complications Matter Most? Prioritizing Quality Improvement in Emergency General Surgery.

Journal Article J Am Coll Surg · April 2016 Featured Publication BACKGROUND: Because preoperative risk factor modification is generally not possible in the emergency setting, complication prevention represents an important focus for quality improvement in emergency general surgery (EGS). The objective of our study was t ... Full text Link to item Cite

Necrotizing pancreatitis: challenges and solutions.

Journal Article Clin Exp Gastroenterol · 2016 Acute pancreatitis is a common disease that can progress to gland necrosis, which imposes significant risk of morbidity and mortality. In general, the treatment for pancreatitis is a supportive therapy. However, there are several reasons to escalate to sur ... Full text Link to item Cite

Gastrointestinal bleeding: A practical approach to diagnosis and management, second edition

Book · January 1, 2016 The latest edition of this text provides a practical reference for physicians and other health care providers caring for patients with gastrointestinal bleeding. Similar to the previous edition, this volume addresses common problems associated with gastroi ... Full text Cite

Secretin

Chapter · January 1, 2016 Secretin, a 27-amino-acid peptide hormone produced by intestinal S cells, is released into the duodenum primarily in response to pH changes following food ingestion. Its major target organs include the pancreas, stomach, and gallbladder. Secretin affects p ... Full text Cite

Laparoscopic Total Gastrectomy in the Western Patient Population: Tips, Techniques, and Evidence-based Practice.

Journal Article Surg Laparosc Endosc Percutan Tech · December 2015 Featured Publication Gastric cancer is the second most common malignancy worldwide, and surgical resection is the only curative treatment. Traditionally, open total gastrectomy has been the procedure of choice for large and proximal carcinomas. Over the past decade, however, l ... Full text Link to item Cite

A medical history of Governor John B. Connally and his gunshot wounds.

Journal Article J Trauma Acute Care Surg · November 2015 Featured Publication : On November 22, 1963, the Governor of Texas, John Connally, was injured during the assassination of President John F. Kennedy. Multiple authors have documented President Kennedy's injuries, the attempted resuscitation, and the controversies surrounding t ... Full text Link to item Cite

Review of complications associated with endoscopic pancreatic cyst-gastrostomy: a single-institution experience.

Journal Article Surg Laparosc Endosc Percutan Tech · June 2015 Featured Publication BACKGROUND: Pancreatic fluid collections can form after episodes of pancreatitis, either acute or chronic. The majority will resolve spontaneously but when decompression is mandated, endoscopic drainage is the method of choice. However, it is not void of c ... Full text Link to item Cite

Laparoscopic duodenectomy for benign nonampullary duodenal neoplasms.

Journal Article Surg Laparosc Endosc Percutan Tech · April 2015 Featured Publication BACKGROUND: The aim of this study was to review our experience with laparoscopic duodenectomy for benign duodenal neoplasms and compare with a contemporary cohort of open duodenectomy. METHODS: Twelve cases of laparoscopic duodenectomy for benign duodenal ... Full text Link to item Cite

The impact of functional dependency on outcomes after complex general and vascular surgery.

Journal Article Ann Surg · March 2015 Featured Publication OBJECTIVE: To describe the outcomes of functionally dependent patients who undergo major general or vascular surgery and to determine the relationship between functional health status and early postoperative outcomes. BACKGROUND: In contrast to frailty, fu ... Full text Link to item Cite

Surgical management of necrotizing pancreatitis: an overview.

Journal Article World J Gastroenterol · November 21, 2014 Featured Publication Necrotizing pancreatitis is an uncommon yet serious complication of acute pancreatitis with mortality rates reported up to 15% that reach 30% in case of infection. Traditionally open surgical debridement was the only tool in our disposal to manage this ser ... Full text Link to item Cite

Defining the learning curve for team-based laparoscopic pancreaticoduodenectomy.

Conference Ann Surg Oncol · November 2014 Featured Publication BACKGROUND: The purpose of this study was to define the learning curves for laparoscopic pancreaticoduodenectomy (LPD) with and without laparoscopic reconstruction, using paired surgical teams consisting of advanced laparoscopic-trained surgeons and advanc ... Full text Link to item Cite

Vagotomy/drainage is superior to local oversew in patients who require emergency surgery for bleeding peptic ulcers.

Journal Article Ann Surg · June 2014 Featured Publication OBJECTIVE: To compare early postoperative outcomes of patients undergoing different types of emergency procedures for bleeding or perforated gastroduodenal ulcers. BACKGROUND: Although definitive acid-reducing procedures are being used less frequently duri ... Full text Link to item Cite

Feeding jejunostomy during Whipple is associated with increased morbidity.

Journal Article J Surg Res · April 2014 Featured Publication BACKGROUND: Placement of a feeding jejunostomy tube (FJ) is often performed during pancreaticoduodenectomy (PD). Few studies, however, have sought to determine whether such placement affects postoperative outcomes after PD. MATERIALS AND METHODS: This is a ... Full text Link to item Cite

A relic or still relevant: the narrowing role for vagotomy in the treatment of peptic ulcer disease.

Journal Article Am J Surg · January 2014 Featured Publication BACKGROUND: Given the rise of medical treatment for peptic ulcer disease (PUD), surgical treatment is necessary only in select cases and emergencies. The authors assess the current relevance of surgical vagotomy to treat PUD and its complications. DATA SOU ... Full text Link to item Cite

Resident education in the era of patient safety: a nationwide analysis of outcomes and complications in resident-assisted oncologic surgery.

Journal Article Ann Surg Oncol · November 2013 Featured Publication BACKGROUND: Complex, oncologic surgery is an important component of resident education. Our objective was to evaluate the impact of resident participation in oncologic procedures on overall 30-day morbidity and mortality. METHODS: A retrospective cohort an ... Full text Link to item Cite

Gallstone ileus: revisiting surgical outcomes using National Surgical Quality Improvement Program data.

Journal Article J Surg Res · September 2013 Featured Publication BACKGROUND: Although surgical management remains the mainstay of therapy for gallstone ileus, the optimal approach--enterolithotomy alone or combined with biliary-enteric fistula disruption--is controversial because of the reliance on small single-center s ... Full text Link to item Cite

The role of local excision in invasive adenocarcinoma of the ampulla of Vater.

Journal Article J Gastrointest Oncol · March 2013 Featured Publication BACKGROUND: Ampulla of Vater carcinomas are rare malignancies that have been traditionally treated with radical surgical resection. Given the mortality associated with pancreaticoduodenectomy, some patients may benefit from local resection. A single-instit ... Full text Link to item Cite

Endoscopic versus surgical ampullectomy: an algorithm to treat disease of the ampulla of Vater.

Journal Article Ann Surg · February 2013 Featured Publication OBJECTIVE: The objective of this study was to compare the effectiveness, morbidity, and mortality associated with endoscopic ampullectomy (EA) and surgical ampullectomy (SA). BACKGROUND: The proposed management of benign ampullary lesions includes local re ... Full text Link to item Cite

Phlebitis, pulmonary emboli and presidential politics: Richard M. Nixon's complicated deep vein thrombosis.

Journal Article Am Surg · February 2013 Featured Publication In September of 1974, Richard Nixon resigned the Presidency of the United States during an impeachment investigation concerning the Watergate Affair. One month after his resignation, the former President had an exacerbation of his chronic deep vein thrombo ... Link to item Cite

Contemporary surgical management of liver, biliary tract, and pancreatic disease

Book · January 1, 2013 Contemporary Surgical Management of Liver, Biliary Tract, and Pancreatic Diseases presents an excellent resource for surgical residents, hepatobiliary fellows and practicing surgeons interested in hepatobiliary surgery. This textbook offers a readable, con ... Full text Cite

Periampullary cancer

Chapter · January 1, 2013 Full text Cite

Acute pancreatitis

Chapter · January 1, 2013 Full text Cite

Imaging of the biliary tree

Chapter · January 1, 2013 Full text Cite

Expectations and outcomes in geriatric patients with do-not-resuscitate orders undergoing emergency surgical management of bowel obstruction.

Journal Article JAMA Surg · January 2013 Featured Publication OBJECTIVE: To describe the outcomes and the expected postoperative course for patients with do-not-resuscitate (DNR) orders (DNR patients) who undergo emergency surgical management of bowel obstruction. DESIGN: We retrospectively identified all patients wh ... Full text Link to item Cite

Post-operative nutrition in patients undergoing pancreaticoduodenectomy

Journal Article Journal of Surgical Radiology · 2013 Featured Publication Purpose: Pancreaticoduodenectomy is the standard surgical treatment for resectable periampullary and pancreatic head malignancies as well as some benign conditions confi ned to the pancreatic head. Peri-operative nutrition is a well-recognized aspect of ca ... Cite

The impact of vascular resection on early postoperative outcomes after pancreaticoduodenectomy: an analysis of the American College of Surgeons National Surgical Quality Improvement Program database.

Journal Article Ann Surg Oncol · December 2012 Featured Publication BACKGROUND: Several single-center reports suggest that vascular resection (VR) during pancreaticoduodenectomy (PD) for patients with pancreatic adenocarcinoma is feasible without affecting early postoperative mortality or morbidity. Our objective is to rev ... Full text Link to item Cite

Failure-to-pursue rescue: explaining excess mortality in elderly emergency general surgical patients with preexisting "do-not-resuscitate" orders.

Journal Article Ann Surg · September 2012 Featured Publication OBJECTIVE: To describe the outcomes of elderly patients with do-not-resuscitate (DNR) status who undergo emergency general surgery and to improve understanding of the relationship between preoperative DNR status and postoperative mortality. BACKGROUND: Pre ... Full text Link to item Cite

Does preoperative therapy optimize outcomes in patients with resectable pancreatic cancer?

Journal Article J Surg Oncol · July 1, 2012 Featured Publication The objective of this study was to compare survival between all patients with radiographically resectable adenocarcinoma of the proximal pancreas who underwent preoperative chemoradiation therapy (PRE-OP CRT) or surgical exploration first (SURGERY) with "i ... Full text Link to item Cite

Vascular surgery collaboration during pancreaticoduodenectomy with vascular reconstruction.

Journal Article Ann Vasc Surg · July 2012 Featured Publication BACKGROUND: Once thought to have unresectable disease, pancreatic cancer patients with portal venous involvement are now reported to have comparable survival after pancreaticoduodenectomy (PD) with vascular reconstruction (VR) as compared with patients wit ... Full text Link to item Cite

Racial disparities in outcomes after appendectomy for acute appendicitis.

Journal Article Am J Surg · July 2012 Featured Publication BACKGROUND: Although black patients with acute appendicitis have been shown to be less likely than whites to undergo laparoscopic appendectomy, it is unknown whether they suffer increased complications after surgical management of acute appendicitis. METHO ... Full text Link to item Cite

Locoregional versus general anesthesia for open inguinal herniorrhaphy: a National Surgical Quality Improvement Program analysis.

Journal Article Am Surg · July 2012 Featured Publication Our objective was to study outcomes associated with open inguinal herniorrhaphy performed under locoregional (LR) versus general anesthesia (GA). National Surgical Quality Improvement Program (NSQIP) data from 2005 to 2009 was queried to capture patients u ... Link to item Cite

Neoadjuvant chemoradiation for potentially resectable gastric cancer.

Conference JOURNAL OF CLINICAL ONCOLOGY · May 20, 2012 Link to item Cite

A novel scoring system for predicting postoperative venous thromboembolic complications in patients after open aortic surgery.

Journal Article J Am Coll Surg · April 2012 Featured Publication BACKGROUND: Although the overall incidence of venous thromboembolism (VTE) after open aortic surgery is low, it is not known whether specific factors can place patients at increased risk for this complication. The goal of our study was to identify patient ... Full text Link to item Cite

Anarchy and the surgical care of President William McKinley.

Journal Article J Trauma Acute Care Surg · April 2012 Featured Publication Full text Link to item Cite

Surgical trainee participation during infrainguinal bypass grafting procedures is associated with increased early postoperative graft failure.

Journal Article J Vasc Surg · March 2012 Featured Publication OBJECTIVE: This study was conducted to determine the potential effect of surgical trainee participation during infrainguinal bypass procedures on postoperative graft patency rates. METHODS: Data from the National Surgical Quality Improvement Program (NSQIP ... Full text Link to item Cite

Defining the impact of resident participation on outcomes after appendectomy.

Journal Article Ann Surg · March 2012 Featured Publication OBJECTIVE: To determine whether resident participation impacts complication rates after appendectomy. BACKGROUND: The effect of resident participation on postoperative outcomes has not been well defined. METHODS: Data from the National Surgical Quality Imp ... Full text Link to item Cite

The effect of vascular reconstruction on early postoperative outcomes after pancreaticoduodenectomy: An analysis of the American College of Surgeons National Surgical Quality Improvement Program database.

Journal Article J Clin Oncol · February 2012 153 Background: Several single-center reports have been published suggesting that vascular reconstruction (VR) during pancreaticoduodenectomy (PD) allows an acceptable oncologic outcome in patients with pancreatic adenocarcinoma without affecting early pos ... Link to item Cite

The effect of vascular reconstruction on early postoperative outcomes after pancreaticoduodenectomy: An analysis of the American College of Surgeons National Surgical Quality Improvement Program database.

Conference Journal of Clinical Oncology · February 1, 2012 153 Background: Several single-center reports have been published suggesting that vascular reconstruction (VR) during pancreaticoduodenectomy (PD) allows an acceptable oncologic outcome in patients with pancreatic adenocarcinoma ... Full text Cite

Comparison of outcomes and the use of multimodality therapy in young and elderly people undergoing surgical resection of pancreatic cancer.

Journal Article J Am Geriatr Soc · February 2012 Featured Publication OBJECTIVES: To compare outcomes and the use of multimodality therapy in young and elderly people with pancreatic cancer undergoing surgical resection. DESIGN: Retrospective, single-institution study. SETTING: National Cancer Institute/National Comprehensiv ... Full text Link to item Cite

Why i work at the VA hospital

Other Journal of Surgical Radiology · 2012 Featured Publication Cite

Pre- and intraoperative variables affecting early outcomes in elderly patients undergoing pancreaticoduodenectomy.

Journal Article HPB (Oxford) · December 2011 Featured Publication BACKGROUND: Conflicting data exist regarding the safety of pancreatic resections in elderly patients. In this study we compared early complication and mortality rates between patients younger and older than 80 years of age who underwent pancreaticoduodenec ... Full text Link to item Cite

Complex abdominal wall hernias: a new classification system and approach to management based on review of 133 consecutive patients.

Journal Article Ann Plast Surg · May 2011 Featured Publication BACKGROUND: Plastic surgeons are increasingly involved in the repair of complex ventral hernias. Although this typically involves recurrent incisional hernias, operative strategies can be applied to most abdominal wall defects, including chronic wounds wit ... Full text Link to item Cite

The volume-outcomes relationship for United States Level I trauma centers.

Journal Article J Surg Res · May 1, 2011 Featured Publication BACKGROUND: Previous studies of the center volume-outcomes relationship for severe trauma care have yielded conflicting findings regarding the presence or nature of such a relationship. Few studies have confined their analysis to Level I centers. METHODS: ... Full text Link to item Cite

Gastrointestinal bleeding: A practical approach to diagnosis and management

Book · December 1, 2010 The diagnosis and management of gastrointestinal bleeding is multidisciplinary by nature involving surgeons, gastroenterologists and radiologists. Due to various pathologies, it involves upper gut, lower gut and occult bleeding. Gastrointestinal Bleeding: ... Full text Cite

Management of bleeding peptic ulcer disease

Chapter · December 1, 2010 Peptic ulcers are defects in the gastrointestinal mucosa that extend through the muscularis mucosae. They persist as a function of the acid or peptic activity in gastric juice. The natural history of peptic ulcer disease (PUD) ranges from resolution withou ... Full text Cite

Gentamicin-collagen sponge for infection prophylaxis in colorectal surgery.

Journal Article N Engl J Med · September 9, 2010 Featured Publication BACKGROUND: Despite the routine use of prophylactic systemic antibiotics, surgical-site infection continues to be associated with significant morbidity and cost after colorectal surgery. The gentamicin-collagen sponge, an implantable topical antibiotic age ... Full text Link to item Cite

Patient socioeconomic status is an independent predictor of operative mortality.

Journal Article Ann Surg · September 2010 Featured Publication OBJECTIVE: To evaluate the impact of patient socioeconomic status (SES) on operative mortality within the context of associated factors. SUMMARY OF BACKGROUND DATA: Outcomes disparities among surgical patients are a significant concern. Previous studies ha ... Full text Link to item Cite

Incidence of benign disease in patients that underwent resection for presumed pancreatic cancer diagnosed by endoscopic ultrasonography (EUS) and fine-needle aspiration (FNA).

Journal Article J Gastrointest Surg · July 2010 Featured Publication INTRODUCTION: The lack of accurate markers makes preoperative differentiation between pancreatic cancer and non-malignant head lesions clinically challenging. In this study, we investigated the incidence of benign disease in patients that underwent resecti ... Full text Link to item Cite

Trends in the utilization of high-volume hospitals by minority and underinsured surgical patients.

Journal Article Am Surg · May 2010 Featured Publication Race- and insurance-based disparities exist in the utilization of high-volume hospitals for complex surgery. Retrospective analysis of the Nationwide Inpatient Sample from 1988 through 2005 was performed to examine hospital volume trends for eight procedur ... Link to item Cite

Temporal trends in lung transplant center volume and outcomes in the United States.

Journal Article Transplantation · March 27, 2010 Publicly available program-specific data from the scientific registry of transplant recipients were used to determine the association between adult lung transplant center volume and 1-year recipient mortality from 2000 to 2007. We found a significant inver ... Full text Link to item Cite

Defining criteria for selective operative management of pancreatic cystic lesions: does size really matter?

Journal Article J Gastrointest Surg · February 2010 INTRODUCTION: Proposed criteria for resection of pancreatic cystic lesions have included symptoms, size (>3 cm), and suspicious features by endoscopic ultrasound (EUS). The objective of this study was to evaluate risk factors for malignancy in a large seri ... Full text Link to item Cite

Low volume is associated with worse patient outcomes for pediatric liver transplant centers.

Journal Article J Pediatr Surg · January 2010 BACKGROUND: An inverse association between hospital procedure volume and postoperative mortality has been demonstrated for a variety of pediatric surgical procedures. The objective of our study was to determine whether such an association exists for pediat ... Full text Link to item Cite

Intracerebroventricular infusion of bombesin modulates GIP secretion in conscious dogs.

Journal Article Neuropharmacology · January 2010 UNLABELLED: Glucose-dependent insulinotropic polypeptide (GIP) is an incretin with important role in glucose homeostasis and energy conservation. Thus far, the neural mechanisms involved in the regulation of GIP secretion, have not yet been fully elucidate ... Full text Link to item Cite

Pancreaticoduodenectomy: frequency and outcome of post-operative imaging-guided percutaneous drainage.

Journal Article Abdom Imaging · November 2009 BACKGROUND: To study the frequency and outcomes of percutaneous imaging-guided drainage following pancreaticoduodenectomy and to assess if fluid collection location correlates with pancreatic duct leak. METHODS: IRB approval was obtained. Three hundred and ... Full text Link to item Cite

Laparoscopic surgical treatment for refractory gastric antral vascular ectasia: a case report and review.

Journal Article Surg Laparosc Endosc Percutan Tech · October 2009 Gastric antral vascular ectasia (GAVE) is an angiodysplastic disorder of unclear etiology and rare cause of upper gastrointestinal bleeding. Endoscopic findings of hyperemic antral folds with dilated, tortuous vessels extending radially from the pylorus ar ... Full text Link to item Cite

For patients with predicted low risk for choledocholithiasis undergoing laparoscopic cholecystectomy, selective intraoperative cholangiography and postoperative endoscopic retrograde cholangiopancreatography is an effective strategy to limit unnecessary procedures.

Journal Article Surg Endosc · September 2009 BACKGROUND: There is debate about whether intraoperative cholangiography (IOC) should be performed routinely or selectively during laparoscopic cholecystectomy (LC) in patients with suspected choledocholithiasis. The timing of endoscopic retrograde cholang ... Full text Link to item Cite

Effect of intracerebroventricular infusion of insulin on glucose-dependent insulinotropic peptide in dogs.

Journal Article Neurosci Lett · August 28, 2009 UNLABELLED: Glucose-dependent insulinotropic polypeptide (GIP), is an incretin with important role in glucose homeostasis and energy conservation. Thus far, the neural/hormonal mechanisms involved in the regulation of GIP secretion, have not yet been fully ... Full text Link to item Cite

Temporal trends in liver transplant centre volume in the USA.

Journal Article HPB (Oxford) · August 2009 BACKGROUND: Although prior studies have suggested an inverse association between liver transplant centre volume and postoperative patient mortality, more recent analyses have failed to confirm this association. To date, all studies of the relationship betw ... Full text Link to item Cite

Modified puestow lateral pancreaticojejunostomy.

Journal Article J Gastrointest Surg · May 2009 INTRODUCTION: There are various surgical options for the treatment of pain associated with chronic pancreatitis. The modified Puestow lateral pancreaticojejunostomy has been proven to be effective in ameliorating symptoms and expediting return to normal li ... Full text Link to item Cite

Concurrent chemoradiotherapy in resected extrahepatic cholangiocarcinoma.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2009 PURPOSE: Extrahepatic cholangiocarcinoma is a rare malignancy. Despite radical resection, survival remains poor, with high rates of local and distant failure. To clarify the role of radiotherapy with chemotherapy, we performed a retrospective analysis of r ... Full text Link to item Cite

The fate of patients who undergo "preoperative" ERCP to clear known or suspected bile duct stones.

Journal Article Surg Endosc · January 2009 BACKGROUND: There is debate as to whether recurrent biliary complications are more common in patients who do not have elective cholecystectomy after endoscopic retrograde cholangiopancreatography (ERCP) management of common bile duct (CBD) stones. The aim ... Full text Link to item Cite

Extrinsic surgical denervation ameliorates TNBS-induced colitis in rats.

Journal Article Hepatogastroenterology · 2009 BACKGROUND/AIMS: Neurogenic inflammation refers to an inflammatory reflex arc by sensory neurons which transmit nocious stimulus centrally and results in both pain perception and intense local inflammatory reaction. Specific neurons, receptors, and their r ... Link to item Cite

A Debt Unpaid, Remembering David Coston Sabiston IN MEMORIAM

Other ANNALS OF SURGERY · 2009 Featured Publication Full text Cite

Principles of minimally invasive surgery

Chapter · December 1, 2008 The historical development of laparoscopy can be traced to early in the 19th century when Bozzini, an Italian physician living in Germany, first examined the abdominal cavity using reflected candlelight.1 In 1901, George Kelling, a German, described the es ... Full text Cite

Regionalization of hepatic resections is associated with increasing disparities among some patient populations in use of high-volume providers.

Journal Article J Am Coll Surg · December 2008 BACKGROUND: The goal of our study was to determine the temporal trends in provider volume for liver resection procedures. STUDY DESIGN: The Nationwide Inpatient Sample database for 1988 through 2003 was used to determine temporal trends in hospital and sur ... Full text Link to item Cite

Relationship between provider volume and outcomes for orthotopic liver transplantation.

Journal Article J Gastrointest Surg · September 2008 INTRODUCTION: Recent data suggests that the previously demonstrable relationship between hospital volume and outcomes for liver transplant procedures may no longer exist. Furthermore, to our knowledge, no study has been published examining whether individu ... Full text Link to item Cite

Endogenous ghrelin and 5-HT regulate interdigestive gastrointestinal contractions in conscious rats.

Journal Article Am J Physiol Gastrointest Liver Physiol · August 2008 Endogenous ghrelin causes interdigestive contractions of the stomach in rats. In contrast, previous studies showed that 5-HT(3) and 5-HT(4) receptors were involved in regulating intestinal interdigestive contractions. We studied the possible role of endoge ... Full text Link to item Cite

Peripheral plasma corticotropin-releasing factor concentration does not correlate with augmented colonic motility in response to restraint stress in rats.

Journal Article Clin Exp Pharmacol Physiol · August 2008 1. Corticotropin-releasing factor (CRF) alters colonic motor function in response to restraint stress. It remains unclear whether peripheral CRF released by restraint stress correlates with stress-mediated colonic motility. 2. One strain gauge transducer w ... Full text Link to item Cite

Does ghrelin explain accelerated gastric emptying in the early stages of diabetes mellitus?

Journal Article Am J Physiol Regul Integr Comp Physiol · June 2008 During the early stages of diabetes, gastric emptying is often accelerated, rather than delayed. The mechanism of accelerated gastric emptying in diabetes has not been fully studied. A recent study showed that plasma ghrelin levels were elevated in diabete ... Full text Link to item Cite

Surgical autonomic denervation results in altered colonic motility: an explanation for low anterior resection syndrome?

Journal Article Surgery · June 2008 BACKGROUND: We hypothesized that the bowel dysfunction known as low anterior resection syndrome is caused by denervation of the left colon. The purpose of this study is to determine how surgical denervation changes left colon motility and to identify the m ... Full text Link to item Cite

Daily intake of high dietary fiber slows accelerated colonic transit induced by restrain stress in rats.

Journal Article Dig Dis Sci · May 2008 BACKGROUND: Stress and central corticotropin releasing factor (CRF) are contributing factors to the pathogenesis of irritable bowel syndrome (IBS). It has been shown that restraint stress and central CRF stimulate colonic motility in rats. Short-chain fatt ... Full text Link to item Cite

Workforce projections for hepato-pancreato-biliary surgery.

Journal Article J Am Coll Surg · April 2008 BACKGROUND: We wanted to determine whether current levels of fellowship training in hepato-pancreato-biliary (HPB) surgery will be sufficient to meet demand for HPB procedures in 2020. STUDY DESIGN: The Nationwide Inpatient Sample database for 1988 through ... Full text Link to item Cite

Fixed feeding potentiates interdigestive gastric motor activity in rats: importance of eating habits for maintaining interdigestive MMC.

Journal Article Am J Physiol Gastrointest Liver Physiol · March 2008 Endogenous ghrelin regulates the occurrence of interdigestive gastric phase III-like contractions in rats. However, the fasted motor pattern is not as regular and potent in humans and dogs. We hypothesize that eating habits play an important role in mainta ... Full text Link to item Cite

Effects of electroacupuncture on gastric motility and heart rate variability in conscious rats.

Journal Article Auton Neurosci · February 29, 2008 To clarify the mechanism of site-specific effects of acupuncture on gastric motor function, we studied the simultaneous recording of gastric motility and electrocardiogram (ECG) for heart rate variability (HRV) analysis in conscious rats. Gastric motility ... Full text Link to item Cite

Ghrelin accelerates gastric emptying via early manifestation of antro-pyloric coordination in conscious rats.

Journal Article Regul Pept · February 7, 2008 Ghrelin is known to enhance gastric motility and accelerate gastric emptying of liquid and solid food in rats. As solid gastric emptying is regulated by the coordinated motor pattern between the antrum and pylorus (antro-pyloric coordination), we studied t ... Full text Link to item Cite

Surgical volume and the risk of surgical site infection in community hospitals: size matters.

Journal Article Ann Surg · February 2008 OBJECTIVE: To determine if surgical volume affects the risk of surgical site infections (SSI) in community hospitals. BACKGROUND: The utility of public reporting and the optimal methods to employ when reporting SSI rates remain controversial and contentiou ... Full text Link to item Cite

Supply and demand for liver transplant surgery: are we training enough surgeons?

Journal Article HPB (Oxford) · 2008 The purpose of our study is to determine whether the current level of transplant fellow training is sufficient to meet the future demand for liver transplantation in the United States. Historical data from the Nationwide Inpatient Samples (NIS) for the yea ... Full text Link to item Cite

Duodenal adenocarcinoma: patterns of failure after resection and the role of chemoradiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2007 PURPOSE: To report patterns of disease recurrence after resection of adenocarcinoma of the duodenum and compare outcomes between patients undergoing surgery only vs. surgery with concurrent chemotherapy and radiation therapy (CT-RT). METHODS AND MATERIALS: ... Full text Link to item Cite

Necrotizing pancreatitis: diagnosis and management.

Journal Article Surg Clin North Am · December 2007 Necrotizing pancreatitis is a severe disease characterized by gland necrosis and a destructive systemic inflammatory response. Early management involves aggressive resuscitative and supportive measures. Outcomes are primarily determined by the presence of ... Full text Link to item Cite

Management of Common Bile Duct Injuries

Journal Article Operative Techniques in General Surgery · December 1, 2007 Full text Cite

Laparoscopic distal pancreatectomy with splenic preservation.

Journal Article Surg Endosc · December 2007 BACKGROUND: The technique of distal pancreatectomy has been well described, both with en bloc resection of the spleen and with splenic preservation. Splenic preservation during pancreatic tail resection is desirable when oncologically appropriate, yet it i ... Full text Link to item Cite

Concurrent Chemoradiation for Resectable Extrahepatic Cholangiocarcinoma

Conference International Journal of Radiation Oncology*Biology*Physics · November 2007 Full text Cite

Extended hepatic resection for gallbladder cancer.

Journal Article Am J Surg · September 2007 BACKGROUND: Although radical cholecystectomy is the standard of care for gallbladder cancers that invade perimuscular connective tissue or perforate visceral peritoneum, the role of extended right hepatectomy in achieving negative resection margins is not ... Full text Link to item Cite

Functional evaluation of the grafted wall with porcine-derived small intestinal submucosa (SIS) to a stomach defect in rats.

Journal Article Surgery · September 2007 BACKGROUND: Small intestinal submucosa (SIS) represents a novel bio-scaffolding material that may be used to repair hollow-organ defects. However, it is unclear whether neurophysiologic responses return to SIS-grafted areas in the gut. We evaluated the fun ... Full text Link to item Cite

Central effects of morphine on GI motility in conscious dogs.

Journal Article Brain Res · August 29, 2007 It has been suggested that morphine has dual effects; emetic effects and anti-emetic effects. The chemoreceptor trigger zone, which is outside the BBB, mediates the emetic effect. In contrast, the vomiting center mediates the anti-emetic effect of opioids. ... Full text Link to item Cite

Endogenous acyl ghrelin is involved in mediating spontaneous phase III-like contractions of the rat stomach.

Journal Article Neurogastroenterol Motil · August 2007 In humans and dogs, it is known that motilin regulates phase III contractions of migrating motor complex (MMC) in the fasted state. In rats, however, motilin and its receptor have not been found, and administration of motilin failed to induce any phase III ... Full text Link to item Cite

Inhibition of sympathetic pathways restores postoperative ileus in the upper and lower gastrointestinal tract.

Journal Article J Gastroenterol Hepatol · August 2007 BACKGROUND AND AIM: Postoperative ileus (POI) is a transient bowel dysmotility following abdominal surgery. The effects of adrenergic blocking agents and celiac ganglionectomy were studied in rats to investigate the possible involvement of the adrenergic p ... Full text Link to item Cite

Luminally released serotonin stimulates colonic motility and accelerates colonic transit in rats.

Journal Article Am J Physiol Regul Integr Comp Physiol · July 2007 Enterochromaffin (EC) cells of the epithelial cells release 5-HT into the lumen, as well as basolateral border. However, the physiological role of released 5-HT into the lumen is poorly understood. Concentrations of 5-HT in the colonic mucosa, colonic lume ... Full text Link to item Cite

Small intestinal submucosa (SIS) in the repair of a cecal wound in unprepared bowel in rats.

Journal Article J Gastrointest Surg · July 2007 PURPOSE: Porcine-derived small intestinal submucosa (SIS) has been accepted as an acellular matrix for tissue regeneration. However, its use for remodeling gastrointestinal defects has been poorly investigated. Our previous study of the rodent stomach has ... Full text Link to item Cite

Extended resection for pancreatic adenocarcinoma.

Journal Article Oncologist · June 2007 Adenocarcinoma of the pancreas presents a number of therapeutic challenges. Given the poor long-term outcomes after pancreaticoduodenectomy (PD), many surgeons have sought to improve survival via a radical or "extended" pancreatectomy which may include (a) ... Full text Link to item Cite

Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT3 receptors in conscious rats.

Journal Article Am J Physiol Gastrointest Liver Physiol · April 2007 Although restraint stress accelerates colonic transit via a central corticotropin-releasing factor (CRF), the precise mechanism still remains unclear. We tested the hypothesis that restraint stress and central CRF stimulate colonic motility and transit via ... Full text Link to item Cite

Fecal pellet output does not always correlate with colonic transit in response to restraint stress and corticotropin-releasing factor in rats.

Journal Article J Gastroenterol · April 2007 BACKGROUND: Fecal pellet output has been assessed as a colonic motor activity because of its simplicity. However, it remains unclear whether an acceleration of colonic transit correlates well with an increase in fecal pellet output. We examined the causal ... Full text Link to item Cite

Glucagon like peptide-1 accelerates colonic transit via central CRF and peripheral vagal pathways in conscious rats.

Journal Article Auton Neurosci · January 30, 2007 Glucagon like peptide-1 (7-36) (GLP-1), one of the gastrointestinal (GI) regulatory peptide, is known to act as a stress related brain neurotransmitter mediating GI function. Central administration of GLP-1 inhibits gastric emptying. However, little is kno ... Full text Link to item Cite

Choledochoduodenostomy

Chapter · January 1, 2007 This procedure was first performed by Riedel in 1888 for an impacted common bile duct stone. The main principle of the procedure is that a side-to-side anastomosis is designed to allow free flow of bile from the common bile duct into the duodenum. © 2007 S ... Full text Cite

Temporal trends in early clinical outcomes and health care resource utilization for liver transplantation in the United States.

Journal Article J Gastrointest Surg · January 2007 INTRODUCTION: Procedures such as liver transplantation, which entail large costs while benefiting only a small percentage of the population, are being increasingly scrutinized by third-party payors. The purpose of our study was to conduct a longitudinal an ... Full text Link to item Cite

Sports hernias.

Journal Article Adv Surg · 2007 Sportsman's hernia is an increasingly recognized cause of chronic groin pain in athletes. Although the definition is controversial, it is a condition of chronic inguinal/pubic exertional pain caused by rectus abdominal wall weakness or injury without a pal ... Full text Link to item Cite

Evaluation of preoperative therapy for pancreatic cancer using a prognostic nomogram.

Journal Article Ann Surg Oncol · November 2006 BACKGROUND: Theoretical benefits of preoperative chemoradiation therapy (preop CRT) for pancreatic cancer include improved efficacy, resectability, and patient selection. The goal of this study was to evaluate the applicability of a nomogram, which was dev ... Full text Link to item Cite

2136

Conference International Journal of Radiation Oncology*Biology*Physics · November 2006 Full text Cite

Central glucagon like peptide-1 delays solid gastric emptying via central CRF and peripheral sympathetic pathway in rats.

Journal Article Brain Res · September 21, 2006 It has been shown that glucagon like peptide-1 (GLP-1) acts on the central nervous system (CNS), in addition to its peripheral actions. Central administration of glucagon like peptide-1 (GLP-1) delays liquid gastric emptying via non-adrenergic, non-choline ... Full text Link to item Cite

The Kraske procedure: a critical analysis of a surgical approach for mid-rectal lesions.

Journal Article J Surg Oncol · September 1, 2006 BACKGROUND AND OBJECTIVES: To analyze the Kraske procedure as an approach to mid-rectal disease. METHODS: Twenty-two patients underwent a Kraske procedure at either Duke University Medical Center, the Durham Veterans Administration Medical Center, or the D ... Full text Link to item Cite

The selective mu opioid receptor antagonist, alvimopan, improves delayed GI transit of postoperative ileus in rats.

Journal Article Brain Res · August 2, 2006 Postoperative ileus (POI) is often exacerbated by opioid analgesic use during and following surgery, since mu opioid receptor activation results in a further delay of gastrointestinal (GI) transit. The effects of alvimopan, a novel, selective, and peripher ... Full text Link to item Cite

Electroacupuncture elicits dual effects: stimulation of delayed gastric emptying and inhibition of accelerated colonic transit induced by restraint stress in rats.

Journal Article Dig Dis Sci · August 2006 Acupuncture has been used for treating functional gastrointestinal (GI) disorders. Animal studies have demonstrated that acupuncture antagonized various stress-induced responses. We investigated the effects of electroacupuncture (EA) at ST-36 (Zusanli; low ... Full text Link to item Cite

Peripherally administered CRF stimulates colonic motility via central CRF receptors and vagal pathways in conscious rats.

Journal Article Am J Physiol Regul Integr Comp Physiol · June 2006 Corticotropin releasing factor (CRF) is one of the most important factors in the mechanism of stress-induced stimulation of colonic motility. However, it is controversial whether stress-induced stimulation of colonic motility is mediated via central or per ... Full text Link to item Cite

A randomized comparison of EUS-guided FNA versus CT or US-guided FNA for the evaluation of pancreatic mass lesions.

Journal Article Gastrointest Endosc · June 2006 BACKGROUND: Diagnosing pancreatic cancer by EUS-FNA is a potentially appealing alternative to percutaneous biopsy. AIM: To compare EUS-FNA with CT or US-guided FNA for diagnosing pancreatic cancer. DESIGN: Single center, prospective, randomized, cross-over ... Full text Link to item Cite

Electroacupuncture improves restraint stress-induced delay of gastric emptying via central glutaminergic pathways in conscious rats.

Journal Article Neurosci Lett · May 15, 2006 Acupuncture has been used for treating functional gastrointestinal (GI) disorders. Animal studies demonstrated that acupuncture improves various stress-induced physiological responses. We investigated the effects of electroacupuncture (EA) at ST-36 (Zusanl ... Full text Link to item Cite

Productivity measures associated with a patient access initiative.

Journal Article Ann Surg · May 2006 OBJECTIVE: To assess financial performance associated with a patient 7-day access initiative. BACKGROUND DATA: Patient access to clinical services is frequently an obstacle at academic medical centers. Conflicting surgeon priorities among academic, clinica ... Full text Link to item Cite

The herbal medicine, Dai-Kenchu-to, accelerates delayed gastrointestinal transit after the operation in rats.

Journal Article J Surg Res · April 2006 BACKGROUND: Post-operative ileus (POI) is a transient bowel dysmotility after operation. We have previously shown that laparotomy alone significantly delayed gastrointestinal (GI) transit, compared to anesthesia alone. The GI transit was further delayed af ... Full text Link to item Cite

Restraint stress augments postprandial gastric contractions but impairs antropyloric coordination in conscious rats.

Journal Article Am J Physiol Regul Integr Comp Physiol · March 2006 Central corticotropin-releasing factor (CRF) plays an important role in mediating restraint stress-induced delayed gastric emptying. However, it is unclear how restraint stress modulates gastric motility to delay gastric emptying. Inasmuch as solid gastric ... Full text Link to item Cite

Pathologic nodal status predicts disease-free survival after neoadjuvant chemoradiation for gastroesophageal junction carcinoma.

Journal Article Ann Surg Oncol · March 2006 BACKGROUND: The incidence of carcinoma of the gastroesophageal junction (GEJ) is rapidly increasing, and the prognosis remains poor. We examined outcomes in patients who received neoadjuvant chemoradiation for GEJ tumors to identify factors that predict di ... Full text Link to item Cite

Electroacupuncture at ST-36 accelerates colonic motility and transit in freely moving conscious rats.

Journal Article Am J Physiol Gastrointest Liver Physiol · February 2006 Acupuncture is useful for functional bowel diseases, such as constipation and diarrhea. However, the mechanisms of beneficial effects of acupuncture on colonic function have scarcely ever been investigated. We tested the hypothesis that electroacupuncture ... Full text Link to item Cite

Increased toxicity with gefitinib, capecitabine, and radiation therapy in pancreatic and rectal cancer: phase I trial results.

Journal Article J Clin Oncol · February 1, 2006 PURPOSE: Overexpression of epidermal growth factor receptor (EGFR) has been associated with aggressive tumor phenotypes, chemotherapy, and radiation resistance, as well as poor survival in preclinical and clinical models. The EGFR inhibitor gefitinib poten ... Full text Link to item Cite

A phase I study of eniluracil/5-FU in combination with radiation therapy for potentially resectable and/or unresectable cancer of the pancreas and distal biliary tract.

Journal Article Cancer Invest · February 2006 PURPOSE: Eniluracil is an effective inactivator of dihydropyrimidine dehydrogenase (DPD). It allows for oral dosing of 5-fluorouracil (5-FU), which may potentially improve the antitumor activity of 5-FU when delivered concurrently with radiotherapy while a ... Full text Link to item Cite

Comparative analysis of vagotomy and drainage versus vagotomy and resection procedures for bleeding peptic ulcer disease: results of 907 patients from the Department of Veterans Affairs National Surgical Quality Improvement Program database.

Journal Article J Am Coll Surg · January 2006 BACKGROUND: The purpose of this study was to determine postoperative outcomes and risk factors for morbidity and mortality in patients requiring surgery for bleeding peptic ulcer disease (PUD). Vagotomy and drainage procedures are technically simpler but a ... Full text Link to item Cite

Effect of neoadjuvant chemoradiation on operative mortality and morbidity for pancreaticoduodenectomy.

Journal Article Ann Surg Oncol · January 2006 BACKGROUND: Neoadjuvant chemoradiotherapy (neo-CRT) is being used with increasing frequency for periampullary tumors, but how it alters the complication rate of pancreaticoduodenectomy (PD) is unclear. METHODS: A retrospective analysis was conducted of 79 ... Full text Link to item Cite

Percutaneous cervical oesophageal cannulation in the dog for the performance of prolonged oesophageal pH and manometric studies.

Journal Article Lab Anim · October 2005 Traditional methods for obtaining oesophageal access in experimental animals are unsuitable for prolonged (24 h) oesophageal pH evaluation, a procedure that is commonly employed in the assessment of human patients suspected of having gastroesophageal reflu ... Full text Link to item Cite

Adjuvant external-beam radiotherapy with concurrent chemotherapy after resection of primary gallbladder carcinoma: a 23-year experience.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2005 PURPOSE: Primary adenocarcinoma of the gallbladder is a rare malignancy. To better define the role of adjuvant radiation therapy and chemotherapy, a retrospective analysis of the outcome of patients undergoing surgery and adjuvant therapy was undertaken. M ... Full text Link to item Cite

Electroacupuncture reduces rectal distension-induced blood pressure changes in conscious dogs.

Journal Article Dig Dis Sci · July 2005 It has been shown that acupuncture relieves symptoms of abdominal pain and bloating in patients with irritable bowel syndrome (IBS). However, the mechanism of beneficial effects of acupuncture still remains unproven. The aim of the present study was to inv ... Full text Link to item Cite

Does resident post graduate year influence the outcomes of inguinal hernia repair?

Journal Article Ann Surg · June 2005 INTRODUCTION: We evaluated the effect of the postgraduate medical education level (PGY) of surgery residents on recurrence of inguinal hernia, complications, and operative time. METHODS: Post hoc analysis was performed on prospectively collected data from ... Full text Link to item Cite

Impaired gastric motor activity after abdominal surgery in rats.

Journal Article Neurogastroenterol Motil · April 2005 Postoperative ileus (POI) is a transient bowel dysmotility that occurs following abdominal surgery. Several mechanisms have been proposed such as neural reflex and inflammatory changes. We focused on gastric motility after abdominal surgery in rats. To inv ... Full text Link to item Cite

Role of vagus nerve in postprandial antropyloric coordination in conscious dogs.

Journal Article Am J Physiol Gastrointest Liver Physiol · March 2005 It is generally believed that gastric emptying of solids is regulated by a coordinated motor pattern between the antrum and pylorus. We studied the role of the vagus nerve in mediating postprandial coordination between the antrum and pylorus. Force transdu ... Full text Link to item Cite

Significance of histological response to preoperative chemoradiotherapy for pancreatic cancer.

Journal Article Ann Surg Oncol · March 2005 BACKGROUND: Neoadjuvant (preoperative) chemoradiotherapy (CRT) for pancreatic cancer offers theoretical advantages over the standard approach of surgery followed by adjuvant CRT. We hypothesized that histological responses to CRT would be significant progn ... Full text Link to item Cite

Surgical autonomic denervation results in altered colonic motility

Conference DISEASES OF THE COLON & RECTUM · March 1, 2005 Link to item Cite

Restraint stress delays solid gastric emptying via a central CRF and peripheral sympathetic neuron in rats.

Journal Article Am J Physiol Regul Integr Comp Physiol · February 2005 Central corticotropin-releasing factor (CRF) delays gastric emptying through the autonomic nervous system. CRF plays an important role in mediating delayed gastric emptying induced by stress. However, it is not clear whether a sympathetic or parasympatheti ... Full text Link to item Cite

Current management of biliary strictures.

Journal Article J Gastrointest Surg · December 2004 Full text Link to item Cite

Laparoscopic staging for hepatobiliary carcinoma.

Journal Article J Gastrointest Surg · December 2004 Full text Link to item Cite

Central effect of mu-opioid agonists on antral motility in conscious rats.

Journal Article Brain Res · October 22, 2004 Centrally applied opioids delay gastric emptying and inhibit intestinal transit. However, the mechanism of inhibitory effects of central opioids on gastric motility still remains unclear. It also remains unclear which opioid receptor (mu, delta, and kappa) ... Full text Link to item Cite

Reducing hospital morbidity and mortality following esophagectomy.

Journal Article Ann Thorac Surg · October 2004 BACKGROUND: Esophagogastrectomy (EG) is a formidable operation with significant morbidity and mortality rates. Risk factor analyses have been performed, but few studies have produced strategies that have improved operative results. This study was performed ... Full text Link to item Cite

Long-term follow-up of a randomized controlled trial of suture versus mesh repair of incisional hernia.

Other Ann Surg · October 2004 Featured Publication OBJECTIVE: The objective of this study was to determine the best treatment of incisional hernia, taking into account recurrence, complications, discomfort, cosmetic result, and patient satisfaction. BACKGROUND: Long-term results of incisional hernia repair ... Full text Link to item Cite

A randomized comparison of a multimodal management strategy versus combination antiemetics for the prevention of postoperative nausea and vomiting.

Journal Article Anesth Analg · July 2004 A multimodal management strategy for the prevention of postoperative nausea and vomiting (PONV) appears to be superior to single-drug prophylaxis. We tested the hypothesis that a multimodal PONV prophylaxis regimen incorporating total IV anesthesia (TIVA) ... Full text Link to item Cite

Complications of pancreaticoduodenectomy after neoadjuvant chemoradiation in patients with and without preoperative biliary drainage.

Journal Article Dig Liver Dis · June 2004 BACKGROUND: It has been suggested that preoperative biliary drainage increases the risk of infectious complications of pancreaticoduodenectomy. AIMS: The aim of this study was to assess complications related to biliary stents/drains and postoperative morbi ... Full text Link to item Cite

Pancreatic duct strictures: identifying risk of malignancy.

Journal Article Ann Surg Oncol · June 2004 BACKGROUND: This study aimed to define PDS characteristics that predict malignancy and would thus invoke further diagnostic evaluation or aggressive treatment. METHODS: 355 cases of PDS were diagnosed by ERCP during a 7-year period at a single institution. ... Full text Link to item Cite

European surgical survey of acute pancreatitis--union of diversity.

Other Am J Gastroenterol · April 2004 Featured Publication The widely variable nature of acute pancreatitis renders it a challenging disease to manage via standardized approaches. King and Siriwardena present their findings from a survey of European surgical approaches to diagnostic and therapeutic management of s ... Full text Link to item Cite

Magnitude of abdominal incision affects the duration of postoperative ileus in rats.

Journal Article Surg Endosc · April 2004 BACKGROUND: The pathogenesis of reduced postoperative ileus (POI) in laparoscopic gastrointestinal (GI) surgery still remains controversial. The aim of this study was to investigate the effect of surgical incision on postoperative ileus. METHODS: The effec ... Full text Link to item Cite

Sporadic gastric carcinoid tumor laparoscopically resected: a case report.

Journal Article JSLS · 2004 Sporadic gastric carcinoid tumors are relatively infrequent malignancies of the stomach. Tumors measuring less than 1 cm can sometimes be safely removed endoscopically; however, larger neoplasias require surgical ablation. The present case report represent ... Link to item Cite

Clinical application of porcine small intestinal submucosa in the management of infected or potentially contaminated abdominal defects.

Journal Article J Gastrointest Surg · January 2004 The repair of abdominal wall defects in potentially contaminated or grossly infected fields presents a difficult clinical problem. Polypropylene mesh is relatively contraindicated in these settings because of the potential for chronic infection. The altern ... Full text Link to item Cite

Laparoscopic Nissen fundoplication for treating reflux in lung transplant recipients.

Journal Article J Gastrointest Surg · January 2004 Gastroesophageal reflux disease may contribute to pulmonary injury and the development of bronchiolitis obliterans syndrome in lung transplant patients. As a result, such individuals are increasingly likely to undergo corrective gastrointestinal surgery. T ... Full text Link to item Cite

Hilar cholangiocarcinoma.

Journal Article J Gastrointest Surg · 2004 Cancer of the biliary tree, including those occurring at the major biliary bifurcation (Klatskin's tumor), is an uncommon malignancy. Meaningful experience with these tumors has been limited to a few centers. Recent reports with increasing numbers of patie ... Full text Link to item Cite

Elective stoma construction improves outcomes in medically intractable pressure ulcers.

Journal Article Dis Colon Rectum · November 2003 PURPOSE: Perineal pressure ulcers are a common and devastating complication for paralyzed or chronically bedridden patients. Controversy exists on the benefit of fecal diversion for the treatment and prevention of these ulcers. This study compared outcomes ... Full text Link to item Cite

Lower frequency of peritoneal carcinomatosis in patients with pancreatic cancer diagnosed by EUS-guided FNA vs. percutaneous FNA.

Journal Article Gastrointest Endosc · November 2003 BACKGROUND: Studies have suggested an increased risk of peritoneal seeding in patients with pancreatic cancer diagnosed by percutaneous FNA. EUS-FNA is an alternate method of diagnosis. The aim of this study was to compare the frequency of peritoneal carci ... Full text Link to item Cite

Percutaneous cholecystostomy in patients with acute cholecystitis: experience of 45 patients at a US referral center.

Journal Article J Am Coll Surg · August 2003 BACKGROUND: Standard treatment for acute cholecystitis is cholecystectomy, but some patients are at high risk for immediate surgery. Percutaneous cholecystostomy might be the procedure of choice in this group. We reviewed the experience of percutaneous cho ... Full text Link to item Cite

Suspected appendicitis.

Other N Engl J Med · July 17, 2003 Featured Publication Full text Link to item Cite

Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats.

Journal Article Am J Physiol Regul Integr Comp Physiol · May 2003 We studied whether physiological concentration of short-chain fatty acids (SCFAs) affects colonic transit and colonic motility in conscious rats. Intraluminal administration of SCFAs (100-200 mM) into the proximal colon significantly accelerated colonic tr ... Full text Link to item Cite

Vanilloid receptor-1 containing primary sensory neurones mediate dextran sulphate sodium induced colitis in rats.

Journal Article Gut · May 2003 BACKGROUND AND AIMS: The role of sensory neurones in colitis was studied by chemical denervation of primary sensory neurones as well as antagonism of the vanilloid receptor-1 (VR-1) in rats prior to administration of dextran sulphate sodium (DSS) to induce ... Full text Link to item Cite

Transthoracic versus transhiatal esophagectomy: a prospective study of 945 patients.

Journal Article J Thorac Cardiovasc Surg · May 2003 OBJECTIVE: Debate continues as to whether transhiatal esophagectomy results in lower morbidity and mortality than transthoracic esophagectomy. Most data addressing this issue are derived from single-institution studies. To investigate this question from a ... Full text Link to item Cite

Tension-free inguinal hernia repair: the design of a trial to compare open and laparoscopic surgical techniques.

Journal Article J Am Coll Surg · May 2003 BACKGROUND: Inguinal hernia is a common condition in men and represents a large component of health-care expenditures. Approximately 700,000 herniorrhaphies are performed each year in the United States. The most effective method of repair of an inguinal he ... Full text Link to item Cite

Inhibitory effects of hyperglycemia on neural activity of the vagus in rats.

Journal Article Intensive Care Med · February 2003 Featured Publication OBJECTIVES: Although it has been demonstrated that hyperglycemia inhibits gastrointestinal (GI) motility, its inhibitory mechanism remains unclear. DESIGN: Electrophysiological study. SETTINGS: As GI motility is under the influence of the vagus, we studied ... Full text Link to item Cite

Clinical practice. Suspected appendicitis.

Journal Article N Engl J Med · January 16, 2003 Featured Publication Full text Link to item Cite

Neural mechanism of acupuncture-induced gastric relaxations in rats.

Journal Article Dig Dis Sci · January 2003 Acupuncture has been used to treat gastrointestinal symptoms in China for more than 3000 years. However, the mechanism of the beneficial effects of acupuncture remains unknown. Strain gauge transducers were implanted on the serosal surface of the stomach t ... Full text Link to item Cite

Surgical management of pancreaticocutaneous fistula.

Journal Article J Gastrointest Surg · 2003 Although enteric drainage of the fistula tract is a widely accepted treatment for pancreaticocutaneous fistula, few data have been published on the outcome of this procedure. We conducted a retrospective chart review of 30 patients with pancreaticocutaneou ... Full text Link to item Cite

Outcomes after esophagectomy: a ten-year prospective cohort.

Journal Article Ann Thorac Surg · January 2003 Featured Publication BACKGROUND: The Department of Veterans Affairs National Surgical Quality Improvement Program is a unique resource to prospectively analyze surgical outcomes from a cross-section of surgical services nationally. We used this database to assess risk factors ... Full text Link to item Cite

Evaluation of porcine-derived small intestine submucosa as a biodegradable graft for gastrointestinal healing.

Journal Article J Gastrointest Surg · January 2003 Featured Publication High-risk anastomoses in the gut may benefit from the application of a synthetic reinforcement to prevent an enteric leak. Recently a porcine-derived small intestine submucosa (SIS) was tested as a bioscaffold in a number of organ systems. The aim of this ... Full text Link to item Cite

Suspected appendicitis - Reply

Other NEW ENGLAND JOURNAL OF MEDICINE · 2003 Featured Publication Cite

Introductory remarks to sabiston Festschrift

Other ANNALS OF SURGERY · 2003 Featured Publication Full text Cite

Laparoscopic antireflux surgery in the lung transplant population.

Journal Article Surg Endosc · December 2002 Featured Publication BACKGROUND: Lung transplantation has emerged as a viable therapeutic option for patients with a variety of end-stage pulmonary diseases. As immediate posttransplant surgical outcomes have improved, the greatest limitation of lung transplantation remains ch ... Full text Link to item Cite

Extensive investigation of patients with mild elevations of serum amylase and/or lipase is 'low yield'.

Journal Article Can J Gastroenterol · December 2002 Featured Publication BACKGROUND: Serum amylase and lipase levels are widely used as markers of pancreatic inflammation. However, it would seem that mild elevations of amylase and lipase rarely predict significant pancreatic pathology. Pancreatic imaging tests are expensive. Th ... Full text Link to item Cite

Pancreatic Fistula.

Journal Article Curr Treat Options Gastroenterol · October 2002 External and internal pancreatic fistulas have a different etiology and natural history. Approximately 50% of internal and 70% to 90% of external pancreatic fistulas can be expected to heal with nonoperative management. Nonclosure is predicted by anatomic ... Full text Link to item Cite

Clinical utility of positron emission tomography in the diagnosis and management of periampullary neoplasms.

Journal Article Ann Surg Oncol · October 2002 Featured Publication BACKGROUND: This study examined the effect that 18-fluorodeoxyglucose positron emission tomography ((18)FDG-PET) imaging had on the clinical management of patients with suspected periampullary malignancy. METHODS: Fifty-four patients with suspected pancrea ... Full text Link to item Cite

Celecoxib (celebrex) increases canine lower esophageal sphincter pressure.

Journal Article J Surg Res · September 2002 Featured Publication BACKGROUND: Prostaglandins inhibit the contraction of gastrointestinal smooth muscle and may decrease lower esophageal sphincter tone. The purpose of this study was to determine whether the cyclooxygenase-2 inhibitor celecoxib (Celebrex) could increase low ... Full text Link to item Cite

ERCP-related perforations: risk factors and management.

Journal Article Endoscopy · April 2002 BACKGROUND AND STUDY AIMS: Perforations during endoscopic retrograde cholangiopancreatography (ERCP) are rare, and the management of these perforations is variable, with some patients requiring immediate surgery and others only conservative management. We ... Full text Link to item Cite

Simple pancreatic cysts: CT and endosonographic appearances.

Journal Article AJR Am J Roentgenol · April 2002 Featured Publication OBJECTIVE. This report describes the CT and endoscopic sonographic appearance of simple pancreatic cysts in three adults. CONCLUSION. Simple pancreatic cysts are typically an incidental finding in adults who have no history of pancreatic disease. The imagi ... Full text Link to item Cite

Laparoscopic repair for perforated peptic ulcer.

Other Ann Surg · March 2002 Featured Publication Full text Link to item Cite

Anti-reflux surgery improves pulmonary function in lung transplant patients

Conference The Journal of Heart and Lung Transplantation · January 2002 Full text Cite

The sixth decision regarding perforated duodenal ulcer.

Journal Article JSLS · 2002 Featured Publication This presentation reviews the literature regarding the current surgical treatment of perforated ulcers, describes the surgical techniques for laparoscopic repair, and reviews the clinical algorithm used by laparoscopic surgeons at Duke University Medical C ... Link to item Cite

Poor outcome and quality of life in female patients undergoing secondary surgery for recurrent peptic ulcer disease.

Journal Article J Gastrointest Surg · 2002 Featured Publication Secondary peptic ulcer surgery is uncommon given the success of a wide variety of medical therapies, plus the good outcome expected after primary peptic ulcer surgery. Early reports of secondary peptic ulcer surgery in the 1950s and 1960s suggested good lo ... Full text Link to item Cite

A canine model of gastroesophageal reflux disease (GERD).

Journal Article Surg Endosc · January 2002 Featured Publication BACKGROUND: Although a variety of antireflux procedures and medications are used to treat gastroesophageal reflux disease (GERD), reliable large-animal models of GERD that can be used to objectively compare the efficacy of these treatments are lacking. MET ... Full text Link to item Cite

Pancreas-preserving duodenectomy in the management of duodenal familial adenomatous polyposis.

Journal Article J Gastrointest Surg · 2002 Featured Publication Most patients with familial adenomatous polyposis (FAP) develop disease in the duodenum. The duodenal lesions mostly occur in the periampullary region, but some patients develop diffuse polyposis involving all parts of the duodenum. These neoplastic polyps ... Full text Link to item Cite

Neoadjuvant chemoradiation for localized adenocarcinoma of the pancreas.

Journal Article Ann Surg Oncol · December 2001 Featured Publication BACKGROUND: The use of neoadjuvant (preoperative) chemoradiotherapy (CRT) for pancreatic cancer has been advocated for its potential ability to optimize patient selection for surgical resection and to downstage locally advanced tumors. This article reports ... Full text Link to item Cite

Complete response to neoadjuvant chemoradiation for rectal cancer does not influence survival.

Journal Article Ann Surg Oncol · December 2001 Featured Publication BACKGROUND: Up to 30% of patients with locally advanced rectal cancer have a complete clinical or pathologic response to neoadjuvant chemoradiation. This study analyzes complete clinical and pathologic responders among a large group of rectal cancer patien ... Full text Link to item Cite

Neoadjuvant chemoradiation for rectal cancer: analysis of clinical outcomes from a 13-year institutional experience.

Journal Article Ann Surg · June 2001 Featured Publication OBJECTIVE: To examine clinical outcomes in patients receiving neoadjuvant chemoradiation for locally advanced rectal adenocarcinoma. SUMMARY BACKGROUND DATA: Preoperative radiation therapy, either alone or in combination with 5-fluorouracil-based chemother ... Full text Link to item Cite

Immediate and long-term outcomes after lateral pancreaticojejunostomy for chronic pancreatitis.

Journal Article Am Surg · May 2001 Featured Publication Lateral pancreaticojejunostomy (LPJ) is the recommended surgical treatment of intractable pain from chronic pancreatitis (CP) with obstruction and ductal dilatation. This study evaluated the etiology, morbidity, mortality, hospital costs, and quality of li ... Link to item Cite

Staging of pancreatic cancer before and after neoadjuvant chemoradiation.

Journal Article J Gastrointest Surg · 2001 Featured Publication Neoadjuvant chemoradiation therapy is used at many institutions for treatment of localized adenocarcinoma of the pancreas. Accurate staging before neoadjuvant therapy identifies patients with distant metastatic disease, and restaging after neoadjuvant ther ... Full text Link to item Cite

Dextran sulfate sodium-induced colitis in immunodeficient rats.

Journal Article Dig Dis Sci · December 2000 Featured Publication To examine the morphology of colitis and study the role of the immune system in colitis, we compared colitis in immunocompetent Wistar-Kyoto rats with that in spontaneously hypertensive rats, known to have T-cell dysfunction. Rats were treated with 3% dext ... Full text Link to item Cite

Local ampullary resection with careful intraoperative frozen section evaluation for presumed benign ampullary neoplasms.

Journal Article Surgery · June 2000 Featured Publication BACKGROUND: Frozen section evaluation has been reported to be inaccurate in detecting foci of adenocarcinoma within adenomas of the ampulla of Vater, leading many authors to advocate pancreaticoduodenectomy as the method of treatment for these neoplasms. T ... Full text Link to item Cite

Lack of evidence for MHC-unrestricted (atypical) recognition of mucin by mucinous pancreatic tumour-reactive T-cells.

Journal Article Br J Cancer · February 2000 Featured Publication Cytotoxic T-cells generated against heterologous, mucinous pancreatic tumour cells were shown to recognize mucin in a major histocombatibility complex (MHC)-unrestricted fashion. In contrast, the present study demonstrates a typical allogeneic response of ... Full text Link to item Cite

Conversion factors for laparoscopic splenectomy for immune thrombocytopenic purpura.

Journal Article Surg Endosc · August 1999 Featured Publication BACKGROUND: Since 1994, 27 patients at our institution have undergone laparoscopic splenectomy for immune thrombocytopenic purpura (ITP). Laparoscopic splenectomy was completed in 22 of these patients. We sought to identify factors that precluded successfu ... Full text Link to item Cite

Laparoscopic biliary and enteric bypass.

Journal Article Semin Surg Oncol · June 1999 Featured Publication Very few patients with a periampullary neoplasm present with resectable disease. Consequently, various operative and non-operative techniques have been developed to palliate patients with unresectable periampullary disease. Laparoscopic biliary (cholecysto ... Full text Link to item Cite

Review article: evaluation of drugs in experimental gut distension models.

Journal Article Aliment Pharmacol Ther · May 1999 Featured Publication Distension of the gastrointestinal tract elicits abdominal pain, as well as sensations such as discomfort or fullness. Many patients with irritable bowel syndrome have been reported to show a reduced threshold to the pain or discomfort due to experimental ... Link to item Cite

Laparoscopy and peripancreatic neoplasia.

Journal Article World J Surg · April 1999 Featured Publication Since its inception laparoscopy has been a valuable tool for diagnosis, and more recently it has become widely accepted as a medium for surgical intervention. In this light, the addition of minimally invasive techniques to the management of peripancreatic ... Full text Link to item Cite

Risk factors for endoscopic perforation in patients undergoing ERCP

Conference GASTROINTESTINAL ENDOSCOPY · April 1, 1999 Link to item Cite

The laparoscopic management of gastroesophageal reflux disease.

Journal Article Adv Surg · 1999 Featured Publication Laparoscopic fundoplication has replaced open fundoplication as the gold standard for the surgical management of patients with GERD. The improvements in technique that have led to the excellent results on long-term follow-up have broadened the indications ... Link to item Cite

Central modulation of rectal distension-induced blood pressure changes by alosetron, a 5-HT3 receptor antagonist.

Journal Article Dig Dis Sci · January 1999 Featured Publication Irritable bowel syndrome (IBS) represents one of the most common gastrointestinal-related diagnoses. Although the precise etiologic basis of IBS is not known, a common presenting symptom is abdominal pain or discomfort that is thought to develop, at least ... Full text Link to item Cite

Pancreatitis complicated by gland necrosis: evolution of findings on contrast-enhanced CT.

Journal Article J Comput Assist Tomogr · 1999 Featured Publication PURPOSE: The purpose of this work was to investigate the natural history of pancreatic necrosis on contrast-enhanced CT in patients managed nonoperatively. METHOD: A computer-based radiology information search revealed 32 patients with pancreatic necrosis ... Full text Link to item Cite

Long term outcome of endoscopic drainage of pancreatic pseudocysts.

Other Am J Gastroenterol · January 1999 Featured Publication Full text Link to item Cite

Preoperative chemoradiation for patients with locally advanced adenocarcinoma of the pancreas.

Journal Article Ann Surg Oncol · 1999 BACKGROUND: Improved resectability is a major theoretical benefit of preoperative chemoradiation for pancreatic cancer. Since 1994, patients at Duke University Medical Center with locally advanced pancreatic cancer have been treated with multimodality preo ... Full text Link to item Cite

Laparoscopic palliation of pancreatic cancer

Other GASTROENTEROLOGY · 1999 Featured Publication Cite

Endoscopic retrograde pancreatography after pancreaticojejunostomy

Conference Gastrointestinal Endoscopy · December 1, 1998 Background: Retrograde surgical drainage is the treatment of choice for relieving incapacitating abdominal pain in patients (pts) with chronic pancreatitis (CP) and pancreatic duct (PD) dilatation. Lateral pancreaticojejunostomy (PJEJ) - the so-called modi ... Cite

Computers in surgical residencies

Journal Article Current Surgery · November 1, 1998 Computerized data management, or information technology (IT), seems less apparent in surgical residencies as compared with the systems being developed on college campuses. Through the use of a telephone survey of residency program coordinators, we sought t ... Cite

Growing use of laparoscopic cholecystectomy in the national Veterans Affairs Surgical Risk Study: effects on volume, patient selection, and selected outcomes.

Journal Article Ann Surg · January 1998 Featured Publication OBJECTIVE: To study the introduction of laparoscopic cholecystectomy to the 43 tertiary-care university-affiliated Veterans Administration medical centers (VAMCs) participating in the National Veterans Affairs Surgical Risk Study from October 1991 through ... Full text Link to item Cite

Total parenteral nutrition alters NPY/PYY receptor levels in the rat brain.

Journal Article Physiol Behav · December 1997 Featured Publication The regulation of appetite and satiety is complex and may involve peptide mediators such as cholecystokinin (CCK) and neuropeptide Y (NPY). Studies have indicated that calories administered enterally and parenterally impact on feeding, and possibly via the ... Full text Link to item Cite

The effect of caloric load and nutrient composition on induction of small intestinal satiety in dogs.

Journal Article Physiol Behav · July 1997 Featured Publication The influence of caloric load and nutrient composition on small intestinal satiety was investigated in six dogs with chronic esophageal fistulas. Dogs received small bowel infusion of a mixed nutrient liquid meal, a fat, carbohydrate, and a protein solutio ... Full text Link to item Cite

Abdomen after a Puestow procedure: postoperative CT appearance, complications, and potential pitfalls.

Journal Article Radiology · June 1997 Featured Publication PURPOSE: To evaluate the postoperative computed tomographic (CT) appearance, complications, and potential pitfalls after a Puestow procedure (lateral side-to-side pancreaticojejunostomy). MATERIALS AND METHODS: Forty CT examinations were performed after th ... Full text Link to item Cite

Benign gastric ulcer masquerading as a submucosal tumor.

Journal Article Endoscopy · May 1997 Featured Publication Full text Link to item Cite

Accessory bile duct leaks after cholecystectomy: Diagnosis and treatment.

Journal Article GASTROINTESTINAL ENDOSCOPY · April 1, 1997 Link to item Cite

Clinical uses of gut peptides.

Journal Article Ann Surg · February 1997 Featured Publication OBJECTIVE: The authors review clinical applications of gut-derived peptides as diagnostic and therapeutic agents. SUMMARY BACKGROUND DATA: An increasing number of gut peptides have been evaluated for clinical use. Earlier uses as diagnostic agents have bee ... Full text Link to item Cite

Central peptidergic control of gastric acid secretion.

Journal Article Gut · February 1997 Featured Publication Full text Link to item Cite

Laparoscopic ventral and incisional hernioplasty.

Journal Article Surg Endosc · January 1997 Featured Publication BACKGROUND: While the first laparoscopic ventral hernia repair was reported in 1992, there have been no studies comparing laparoscopic to conventional ventral herniorrhaphy. METHODS: Twenty-one ventral hernias repaired laparoscopically are compared to a si ... Full text Link to item Cite

The role of laparoscopy in the management of suspected pancreatic and periampullary malignancies.

Journal Article J Gastrointest Surg · 1997 Featured Publication Laparoscopic evaluation of patients with suspected periampullary malignancies has been utilized more frequently in recent years. Its exact role with regard to staging and surgical bypass for palliation have yet to be clearly defined. To better define the r ... Full text Link to item Cite

Accessory bile duct leaks after cholecystectomy: Diagnosis and treatment

Journal Article Gastrointestinal Endoscopy · January 1, 1997 Background: Postoperative bile leak is a common indication for ERCP after cholecystectomy. Aberrant or "accessory" bile duct leaks (ABDL) are difficult to recognize; appropriate treatment is often delayed. The purpose of this study is to review the managem ... Full text Cite

Evidence-based algorithm for management of biliary leaks following laparoscopic cholecystectomy (LC)

Journal Article Gastrointestinal Endoscopy · January 1, 1997 In the era of LC, ERCP is the diagnostic and therapeutic modality of choice for post-up bile leaks. The existing algorithm has to be modified when leaks (a) fail to resolve with stenting or sphx or (b) cannot be localized by ERCP. The following algorithm r ... Full text Cite

Effect of novel gastrin receptor antagonist (GG1) on acid secretion in the dog.

Conference GASTROENTEROLOGY · 1997 Featured Publication Cite

The management of tumors of the ampulla of Vater by local resection.

Journal Article Ann Surg · November 1996 Featured Publication OBJECTIVE: The authors report on indications and results of local excision of tumors of the ampulla of Vater. SUMMARY BACKGROUND DATA: Local excision of ampullary tumors has been performed for nearly a century but remains controversial. The use of this pro ... Full text Link to item Cite

Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum.

Journal Article Gastroenterology · November 1996 Featured Publication BACKGROUND & AIMS: Nerves have been suggested to mediate the effects of bacterial toxins in intestinal diseases. However, the mechanisms involved are unknown. This study examined endogenous substance P (SP) activation of the substance P receptor (SPR) on e ... Full text Link to item Cite

Alterations in hemodynamics and left ventricular contractility during carbon dioxide pneumoperitoneum.

Journal Article Surg Endosc · October 1996 Featured Publication BACKGROUND: Carbon dioxide (CO2) pneumoperitoneum has been shown to adversely affect hemodynamics in patients. This study specifically examines the potential contribution of altered left ventricular contractility (LVC) to hemodynamic changes observed durin ... Full text Link to item Cite

Quality of life after treatment for pancreatitis.

Journal Article Ann Surg · June 1996 Featured Publication OBJECTIVE: The authors evaluated the morbidity, mortality, and quality of life after pancreatic debridement for necrosis and compared these values to those for quality of life after elective medical and surgical management for chronic pancreatitis. SUMMARY ... Full text Link to item Cite

Endoscopic therapy for pancreatic fistulae.

Journal Article GASTROINTESTINAL ENDOSCOPY · April 1, 1996 Link to item Cite

Increased substance P receptor expression by blood vessels and lymphoid aggregates in Clostridium difficile-induced pseudomembranous colitis.

Journal Article Dig Dis Sci · March 1996 Featured Publication Pseudomembranous colitis is most often caused by toxins secreted by Clostridium difficile following bowel flora overgrowth after antibiotic use. The secretory and inflammatory effects observed in C. difficile toxin A-induced enterocolitis in the rat ileum ... Full text Link to item Cite

Low insertion of hepatic segmental duct VII-VIII is an important cause of major biliary injury or misdiagnosis.

Journal Article Am J Surg · January 1996 Featured Publication BACKGROUND: The importance of variant anatomy is only mentioned generally in most articles in this era of laparoscopic cholecystectomy. We report a series of 14 patients in whom a seemingly low insertion of hepatic segmental duct VII-VIII was clinically im ... Full text Link to item Cite

Mechanisms of gastric and esophageal perforations during laparoscopic Nissen fundoplication.

Journal Article Ann Surg · January 1996 Featured Publication OBJECTIVE: The purpose of this study was to determine possible mechanisms of 17 gastric and esophageal perforations that occurred during laparoscopic Nissen fundoplication. METHODS: Specific details of each perforation relating to mechanism of injury, surg ... Full text Link to item Cite

Suction sclerotherapy for the treatment of esophageal varices: a report of a preliminary feasibility study.

Journal Article Dig Dis · 1996 Featured Publication We report a new treatment modality for esophageal varices, suction sclerotherapy, which was designed to lift away mucosa and submucosa during treatment to prevent deep injection and resultant esophageal ulcerations. In order to compare the posttreatment co ... Full text Link to item Cite

Predictors of improvement following endoscopic management of chronic pancreatitis

Conference Gastrointestinal Endoscopy · 1996 Featured Publication Background: Endoscopic therapy is an accepted treatment for pain in chronic pancreatitis, in addition to traditional management. However, guidelines for selecting treatment options have yet to be established. This study addresses 2 questions: (a) which pat ... Cite

Endoscopic therapy for pancreatic fistulae

Conference Gastrointestinal Endoscopy · 1996 Featured Publication INTRODUCTION: Case reports and small series have indicated that endoscopic therapy for pancreatic fistulae (PF) may be successful. This series reviews the experience with PF at a tertiary care referral center. METHODS: A retrospective review of the DUMC en ... Cite

The role of ERCP in the management of biliary leaks following laparoscopic cholecystectomy (LC)

Conference Gastrointestinal Endoscopy · 1996 Featured Publication Background: Despite its distinct advantages and overall safety, LC has its complications, including biliary leak. The role of ERCP in the diagnosis and treatment of post-LC bile leaks is still evolving. We review a tertiary referral center experience of ER ... Cite

Validation of an endoscopic retrograde cholangiopancreatography (ERCP)-based algorithm for the management of pancreatic pseudocysts (PP)

Conference Gastrointestinal Endoscopy · 1996 Featured Publication Background: Our previously published algorithm for management of PP1 assumed that (a) recurrence rates after percutaneous management are related to the presence of pancreatic duct (PD) obstruction or PP communication with the PD and (b) surgical management ... Cite

The role of ERCP in the management of biliary leaks following laparoscopic cholecystectomy (LC)

Conference GASTROINTESTINAL ENDOSCOPY · 1996 Featured Publication Cite

Non-Whipple resection for benign duodenal and ampullary tumors.

Conference GASTROENTEROLOGY · 1996 Featured Publication Cite

Intracerebroventricular galanin-antagonist inhibits sham feeding in the dog.

Conference GASTROENTEROLOGY · 1996 Featured Publication Cite

Mechanism of action of intracisternal apolipoprotein A-IV in inhibiting gastric acid secretion in rats.

Journal Article Gastroenterology · November 1995 Featured Publication BACKGROUND & AIMS: We recently showed that intracisternal injection of apolipoprotein A-IV (apo A-IV), a protein produced by the small intestine in response to fat, inhibits gastric acid secretion. The aim of this study was to investigate the mechanism of ... Full text Link to item Cite

Differential expression of substance P receptors in patients with Crohn's disease and ulcerative colitis.

Journal Article Gastroenterology · September 1995 Featured Publication BACKGROUND & AIMS: Although clinical and pathological differences exist between Crohn's disease (CD) and ulcerative colitis (UC), distinguishing features are often absent, making diagnosis and treatment problematic. This study evaluated the differences in ... Full text Link to item Cite

The learning curve for laparoscopic cholecystectomy. The Southern Surgeons Club.

Journal Article Am J Surg · July 1995 BACKGROUND: The use of laparoscopic surgical procedures without previous training has grown rapidly. At the same time, there have been allegations of increased complications among less experienced surgeons. METHODS: Using multivariate regression analyses, ... Full text Link to item Cite

How selective are the cholecystokinin antagonists in the dog?

Other Gastroenterology · June 1995 Featured Publication Full text Link to item Cite

Pancreatic polypeptide microinjection into the dorsal motor nucleus inhibits pancreatic secretion in rats.

Journal Article Gastroenterology · May 1995 Featured Publication BACKGROUND/AIMS: Pancreatic polypeptide (PP), a hormone released from the pancreas, inhibits pancreatic secretion in vivo but not in vitro, suggesting that the inhibitory action of PP on pancreatic secretion is indirect. Circulating PP in physiological con ... Full text Link to item Cite

Intracisternal injection of TRH antibody blocks gastric emptying stimulated by 2-deoxy-D-glucose in rats.

Other Brain Res · March 13, 1995 Featured Publication We evaluated the effect of 2-deoxy-D-glucose (2-DG) on gastric emptying of a non nutrient solution in conscious rats using a Phenol red method. Intravenous injection of 2-deoxy-D-glucose dose-dependently increased the rate of gastric emptying. This stimula ... Full text Link to item Cite

Cystic duct patency in malignant obstructive jaundice. An ERCP-based study relevant to the role of laparoscopic cholecystojejunostomy.

Journal Article Ann Surg · March 1995 Featured Publication OBJECTIVE: This endoscopic retrograde cholangiopancreatography-(ERCP)based study estimates the potential role of laparoscopic cholecystojejunostomy for palliation of patients with malignant obstructive jaundice. SUMMARY BACKGROUND DATA: Traditional treatme ... Full text Link to item Cite

Apolipoprotein A-IV acts centrally in the brain to reduce the severity of gastric ulceration in the rat.

Other Brain Res · February 27, 1995 Featured Publication We have recently reported that apolipoprotein A-IV (apo A-IV), a protein associated with lipoproteins, acts in the brain to inhibit gastric acid secretion. In the present study, we determined whether or not apo A-IV has an anti-ulcer action via the central ... Full text Link to item Cite

Gastric mucosal damage induced by 2-deoxy-D-glucose involves medullary TRH in the rat.

Journal Article Regul Pept · February 14, 1995 Featured Publication These studies examined the effect of 2-deoxy-D-glucose (2-DG) on gastric mucosal integrity. Intravenous administration of 2-DG in doses of 100 and 125 mg/kg dose-dependently produced multiple, hemorrhagic gastric mucosal lesions while 75 mg/kg of 2-DG fail ... Full text Link to item Cite

Management of biliary complications after heart transplantation.

Journal Article J Heart Lung Transplant · 1995 Featured Publication BACKGROUND: Immunosuppression increases the risk of biliary complications in heart transplant recipients. METHODS: Patients undergoing heart transplantation since 1986 who were at risk for cholelithiasis (n = 60) were retrospectively studied. RESULTS: Chol ... Link to item Cite

Pancreatography and the surgical management of pseudocysts.

Journal Article Gastrointest Endosc Clin N Am · January 1995 Featured Publication Endoscopic pancreatography has played a dominant role in the evolution of surgical treatment of pancreatic pseudocysts. This article presents an algorithm for the management of pseudocyst disease, focusing on pancreatography and elective treatment. Pancrea ... Link to item Cite

The use of pancreatic ductoscopy in the operative management of benign and malignant pancreatic disorders.

Journal Article Surg Endosc · January 1995 Featured Publication Direct visualization of the pancreatic duct was helpful in decision making during complex pancreaticobiliary operations. Two-, 3-, or 5-mm scopes were introduced into the pancreatic ducts of 32 patients with pancreatic disorders. Scopes were passed into th ... Full text Link to item Cite

Reply

Other Gastroenterology · 1995 Featured Publication Cite

QUALITY-OF-LIFE AFTER PANCREATIC DEBRIDEMENT

Conference GASTROENTEROLOGY · 1995 Featured Publication Full text Cite

DELAYED GASTRIC-EMPTYING BY CENTRAL APOLIPOPROTEIN-A-IV IN RATS

Conference GASTROENTEROLOGY · 1995 Featured Publication Full text Cite

Intracisternal injection of apolipoprotein A-IV inhibits gastric secretion in pylorus-ligated conscious rats.

Other Gastroenterology · December 1994 Featured Publication BACKGROUND/AIMS: Fat feeding increases not only serum but also cerebrospinal fluid concentration of apolipoprotein (apo) A-IV, a protein produced mainly by the small intestine in the rat. We hypothesized that apo A-IV may have a central effect on gastric s ... Full text Link to item Cite

Balloon dilatation of the sphincter of Oddi facilitates passage of glass beads from the canine biliary tract.

Journal Article J Laparoendosc Surg · December 1994 Featured Publication Laparoscopic management of common duct stones is increasing. The most widely used technique involves trans-cystic duct scope placement and stone extraction. Occasionally, stones cannot be retrieved and are allowed to pass spontaneously after manipulation o ... Full text Link to item Cite

Stimulation of gastric secretion and enhanced gastric mucosal damage following central administration of pancreatic polypeptide (PP) in rats.

Journal Article Dig Dis Sci · November 1994 Featured Publication The present study was carried out to investigate the central effects of pancreatic polypeptide on gastric secretion and gastric ulcer formation in conscious rats. Intracisternal injection of rat pancreatic polypeptide (62.5, 250, and 1000 ng/rat) into pylo ... Full text Link to item Cite

Localization of cholecystokinin A and cholecystokinin B/gastrin receptors in the canine upper gastrointestinal tract.

Journal Article Gastroenterology · October 1994 Featured Publication BACKGROUND/AIMS: Cholecystokinin (CCK) is a neuropeptide that exerts numerous effects in the gut. To determine the sites of action of CCK, the distribution and properties of CCK receptor subtypes were studied. METHODS: CCK receptors were localized by autor ... Full text Link to item Cite

Substance P binding sites on intestinal lymphoid aggregates and blood vessels in inflammatory bowel disease correspond to authentic NK-1 receptors.

Journal Article Neurosci Lett · September 12, 1994 Featured Publication Previous reports have described the ectopic expression of substance P binding sites on lymphoid aggregates and small blood vessels in inflammatory bowel disease. In this report, three non-peptide NK-1 receptor antagonists, CP-96,345, RP-67,580, and L-703,6 ... Full text Link to item Cite

Intracisternal injection of pancreatic polypeptide stimulates gastric emptying in rats.

Journal Article Neurosci Lett · August 29, 1994 Featured Publication In the present study, we evaluated the effects of central administration of pancreatic polypeptide (PP) on gastric emptying of a liquid meal in conscious rats using a phenol red method. Intracisternal injection of PP (0.5-2.0 micrograms) speeds gastric emp ... Full text Link to item Cite

Neuropeptide Y functions as a physiologic regulator of cephalic phase acid secretion.

Journal Article Regul Pept · August 4, 1994 Featured Publication Neuropeptide Y (NPY) has been established as a potent orexigenic peptide, and recent studies suggest that NPY stimulates cephalic phase secretion as well. However, it is not known whether NPY's effects are pharmacologic or physiologic. In order to determin ... Full text Link to item Cite

Directed enzyme pro-drug gene therapy for pancreatic cancer in vivo.

Journal Article Surgery · August 1994 Featured Publication BACKGROUND: Directed enzyme pro-drug therapy incorporates the delivery of a gene to a cancer cell that will be specifically expressed and will confer sensitivity to a therapeutic agent. Tumor-specific gene expression can be achieved by coupling the promote ... Link to item Cite

Laparoscopic approaches to symptomatic gastroesophageal reflux.

Journal Article Semin Gastrointest Dis · July 1994 Featured Publication Link to item Cite

Effect of CGRP antagonist, alpha-CGRP 8-37, on acid secretion in the dog.

Journal Article Dig Dis Sci · July 1994 Featured Publication The recently synthesized calcitonin gene-related peptide (CGRP) antagonist, human alpha-CGRP 8-37, was used to study its effects on gastric acid secretion. Four dogs with gastric fistula were used to measure the antagonist's physiologic effects in the stom ... Full text Link to item Cite

Intracerebroventricular neuropeptide Y increases gastric acid secretion by decreasing tonic adrenergic inhibition of acid in dogs.

Journal Article Brain Res · January 28, 1994 Featured Publication Neuropeptide Y (NPY) has been shown to increase basal gastric acid secretion in dogs. We examined the hypothesis that NPY might increase gastric acid secretion by interaction with central catecholaminergic control of acid secretion in dogs. Studies were pe ... Full text Link to item Cite

Preface

Chapter · January 1, 1994 Full text Cite

Laparoscopic fundoplication: an alternate approach in the surgical treatment of esophageal reflux (continuing education credit).

Journal Article Todays OR Nurse · 1994 Featured Publication 1. Laparoscopic fundoplication is more "patient friendly" than the comparable open procedure, affording shorter postoperative recovery and faster return of the patient to normal activity. 2. Laparoscopic fundoplication achieves the same results and is esse ... Link to item Cite

Laparoscopic Nissen fundoplication: operative results and short-term follow-up.

Journal Article Am J Surg · January 1994 Featured Publication The operative results, outcome, and short-term follow-up after laparoscopic exploration for Nissen fundoplication were evaluated in 35 patients with symptomatic gastroesophageal reflux and reflux-induced pulmonary disease. There were 19 female and 16 male ... Full text Link to item Cite

Role of neuropeptides in the regulation of feeding behavior: a review of cholecystokinin, bombesin, neuropeptide Y, and galanin.

Journal Article Neurosci Biobehav Rev · 1994 Featured Publication The purpose of this report is to provide a review of four peptides (cholecystokinin, bombesin, neuropeptide Y, galanin) and their role in feeding behavior. Cholecystokinin (CCK) and bombesin (BBS) are considered satiety peptides, and neuropeptide Y (NPY) a ... Full text Link to item Cite

Intracerebroventricular neuropeptide Y increases gastric and pancreatic secretion in the dog.

Journal Article Gastroenterology · October 1993 Featured Publication BACKGROUND: Neuropeptide Y (NPY), a centrally located neurotransmitter, is known to increase appetite in fasted and satiated animals. In addition to evaluating NPY's effect on eating behavior, this study was intended to determine whether intracerebroventri ... Full text Link to item Cite

Short-term oral sensory deprivation: possible cause of binge eating in sham-feeding dogs.

Other Physiol Behav · June 1993 Featured Publication Six mongrel dogs (18-20 kg) were prepared with gastric and esophageal fistulas. All dogs were studied under four experimental conditions. In conditions 1 and 3 the dogs were allowed to sham feed either a high-palatable or low-palatable meal on days 1-5 fol ... Full text Link to item Cite

Exogenous neuropeptide Y blocks myoelectric activity in the upper gastrointestinal tract of starved dogs. Brain neuropeptide Y converts a fasting pattern of myoelectric activity to a fed pattern.

Journal Article Scand J Gastroenterol · June 1993 Featured Publication The effect of intracerebroventricular (ICV) neuropeptide Y (NPY) on the migrating motor complex (MMC) was examined in five starved dogs. Myoelectric activity was recorded using gastric, duodenal, and jejunal electrodes. Intragastric pressure was monitored ... Full text Link to item Cite

Management of major biliary complications after laparoscopic cholecystectomy.

Journal Article Ann Surg · May 1993 OBJECTIVE: A total of 50 major bile duct injuries after laparoscopic cholecystectomy were managed by the Duke University Hepatobiliary Service from 1990-1992. The management of these complex cases is reviewed. SUMMARY BACKGROUND DATA: Laparoscopic cholecys ... Full text Link to item Cite

Taste and smell sensations enhance the satiating effect of both a high-carbohydrate and a high-fat meal in humans.

Journal Article Physiol Behav · March 1993 Featured Publication The effects of meal sensory properties (tasty vs. bland) and nutrient composition [high-CHO (carbohydrate) vs. high-FAT] on hunger ratings, blood glucose and free fatty acids (FFA), taste perception, and subsequent food intake, were studied in human subjec ... Full text Link to item Cite

STAPLED RESECTION OF THE UNCINATE PROCESS DURING WHIPPLE OPERATION

Conference GASTROENTEROLOGY · 1993 Featured Publication Cite

Laparoscopic colectomy--the innovation continues.

Other Ann Surg · December 1992 Featured Publication Full text Link to item Cite

Intracerebroventricular neuropeptide Y stimulates bile secretion via a vagal mechanism.

Journal Article Gut · November 1992 Featured Publication UNLABELLED: The effect of intracerebroventricular injection of neuropeptide Y on biliary secretion was studied in conscious dogs, prepared with gastric and duodenal fistulas and cerebroventricular guides. Bile secretion was increased in a dose-dependent fa ... Full text Link to item Cite

Malignant biliary obstruction: efficacy of thin-section dynamic CT in determining resectability.

Journal Article AJR Am J Roentgenol · September 1992 Featured Publication OBJECTIVE: Several authorities advocate the use of preoperative angiography to determine the resectability of pancreatic and periampullary tumors, claiming that CT alone is not sufficiently accurate for this purpose. Our objective was to assess the value o ... Full text Link to item Cite

Routine choledochotomy with cholecystectomy.

Other Ann Surg · July 1992 Featured Publication Full text Link to item Cite

Irish Society of Gastroenterology. Abstracts.

Conference Ir J Med Sci · March 1992 Featured Publication Full text Link to item Cite

Mechanisms of major biliary injury during laparoscopic cholecystectomy.

Journal Article Ann Surg · March 1992 Featured Publication Laparoscopic cholecystectomy has become the procedure of choice for surgical removal of the gallbladder. The most significant complication of this new technique is injury to the bile duct. Twelve cases of bile duct injury during laparoscopic cholecystectom ... Full text Link to item Cite

The technique of laparoscopic cholecystectomy in children.

Journal Article Ann Surg · February 1992 Featured Publication Twelve children underwent elective laparoscopic cholecystectomy for symptomatic cholelithiasis during a 10-month period in one institution. The operative technique that has been described for adults was modified because of the smaller dimensions of pediatr ... Full text Link to item Cite

Laparoscopic cholecystectomy in young patients with sickle hemoglobinopathies.

Journal Article J Pediatr · January 1992 Featured Publication Nine young patients with sickle hemoglobinopathies successfully underwent laparoscopic cholecystectomy; no complications resulted from the procedure. The mean postoperative hospital stay was 1.6 days. This technique appears to be a safe and efficacious pro ... Full text Link to item Cite

An endoscopic retrograde cholangiopancreatography (ERCP)-based algorithm for the management of pancreatic pseudocysts.

Journal Article Am J Surg · January 1992 Featured Publication In the treatment of pancreatic pseudocysts, percutaneous and endoscopic drainage have, in certain cases, become alternatives to surgery. However, each treatment modality carries risks of complications and recurrences that may be minimized by the appropriat ... Full text Link to item Cite

A prospective analysis of 1518 laparoscopic cholecystectomies.

Other N Engl J Med · April 18, 1991 Featured Publication BACKGROUND AND METHODS: The Southern Surgeons Club conducted a prospective study of 1518 patients who underwent laparoscopic cholecystectomy for treatment of gallbladder disease in order to evaluate the safety of this procedure. RESULTS: Seven hundred fift ... Full text Link to item Cite

Intraoperative use of a 2-mm choledochoscope for the exploration of small bile ducts and the pancreatic duct.

Journal Article Am Surg · April 1991 Featured Publication Intraoperative visualization of the biliary and pancreatic ducts can be difficult in a nondilated system. Very small extra- and intrahepatic bile ducts occasionally require visualization but do not admit the traditional 6.5-mm intraoperative flexible chole ... Link to item Cite

Somatostatin and the treatment of cancer.

Other Ann Surg · March 1991 Featured Publication Full text Link to item Cite

Laparoscopic cholecystectomy and the biliary endoscopist.

Other Gastrointest Endosc · 1991 Featured Publication Full text Link to item Cite

CT of fundoplication.

Journal Article J Comput Assist Tomogr · 1991 Featured Publication To determine the CT findings postfundoplication, we retrospectively compared CT in 22 postfundoplication patients with CT in 22 patients with unrepaired hiatal hernias and gastroesophageal (GE) junction abnormalities and 24 patients with gastric or esophag ... Full text Link to item Cite

Letter to the editor (Reply)

Other Annals of Surgery · 1991 Featured Publication Cite

Geranyl-geranyl acetone: a novel stimulant of secretin release in the dog.

Journal Article Pancreas · September 1990 Featured Publication Geranyl-geranyl acetone (GGA), a new acyclic polyisoprenoid, anti-ulcer drug appears to exert its beneficial effect by stimulating bicarbonate secretion from the stomach and pancreas. Its efficacy in stimulating pancreatic bicarbonate is particularly strik ... Link to item Cite

Primary hypertrophic pyloric stenosis in the adult.

Other Arch Surg · September 1990 Featured Publication Analysis of 100 consecutive patients with pyloric outlet obstruction revealed that 37% of the obstructions were secondary to peptic ulcer disease and 42% were caused by malignant neoplasm. Only a single patient with primary hypertrophic pyloric stenosis wa ... Full text Link to item Cite

The effect of taste on gastric and pancreatic responses in dogs.

Other Physiol Behav · June 1990 Featured Publication Six mongrel dogs with gastric and esophageal fistulas (n = 4) or with gastric and pancreatic fistulas (n = 2) were studied to determine the role of taste on gastric and pancreatic secretion. Stimulation of the back of the throat with a range of tastants pr ... Full text Link to item Cite

100 consecutive common duct explorations without mortality.

Journal Article Ann Surg · March 1990 Featured Publication It has been suggested that the incidence of morbidity and mortality after common duct exploration no longer justifies its use in patients with a gallbladder in situ. Therefore endoscopic sphincterotomy has been advocated for removal of common duct stones b ... Link to item Cite

Letters to the editor (I: Reply)

Other Annals of Surgery · 1990 Featured Publication Cite

Galanin: A neuropeptide inhibitor of the exocrine pancreas

Journal Article Surgical Forum · December 1, 1989 Cite

Gastric distension is a physiologic satiety signal in the dog.

Journal Article Dig Dis Sci · October 1989 Featured Publication Gastric distension is thought to produce satiety, but whether this effect is seen during physiologic distension by food is unknown. The purpose of this study was to determine whether levels of gastric distension seen during a meal have a satiety effect and ... Full text Link to item Cite

Characterization of in vivo acid secretory responses of rabbit with comparison to dog and rat.

Journal Article Dig Dis Sci · June 1989 Featured Publication Even though rabbit gastric glands are a commonly used model for the study of gastric physiology, little is known about the secretion of gastric acid in the rabbit in vivo. Gastric acid secretion in response to pentagastrin, histamine, and bethanechol stimu ... Full text Link to item Cite

Physiologic approaches to the control of obesity.

Journal Article Ann Surg · March 1989 Featured Publication Morbid obesity is a major health problem in this country and throughout the world. In addition to its social stigma (in the western world), obesity exacerbates several disease states such as diabetes, hypertension, cardiac disease and restrictive lung dise ... Full text Link to item Cite

Appendicitis can be treated safely with a negative appendectomy rate of 10%

Journal Article Digestive Surgery · January 1, 1989 The surgical literature supports a negative laparotomy rate of 20% for patients who are explored for the diagnosis of appendicitis. It has been assumed that attempts at decreasing the negative laparotomy rate will increase the perforation rate to above 25% ... Full text Cite

Surgical therapy of localized abdominal non-Hodgkin's lymphomas.

Journal Article Surgery · June 1988 Featured Publication Non-Hodgkin's lymphomas may involve a variety of abdominal organs, including the liver, spleen, gastrointestinal tract, and retroperitoneum. The number of organs potentially involved and the noncontiguous mode of spread make non-Hodgkin's lymphoma a diffic ... Link to item Cite

The effect of somatostatin on experimental intestinal obstruction.

Journal Article Ann Surg · February 1988 Featured Publication The effect of somatostatin (SS-14) was tested in an anesthetized rabbit model of closed-loop ileal obstruction. Experimental groups included (1) immediate treatment (N = 6) receiving SS-14 2,000 pmol X kg-1 X h-1 intravenously (I.V.) beginning at the time ... Full text Link to item Cite

Postprandial neurohormonal control of gastric emptying.

Journal Article Am J Surg · January 1988 Featured Publication The delay in gastric emptying after a meal is thought to result from nutrient distention-induced release of peptides and neurotransmitters in the gut. The potential contribution of the brain and central neuropeptides to the postprandial regulation of gastr ... Full text Link to item Cite

Advances in drug therapy for peptic ulcer disease.

Journal Article Arch Surg · April 1987 Featured Publication Recently, three new drug types have emerged to treat peptic ulceration. We compared the mechanism of action of omeprazole and somatostatin-14, both inhibitors of gastric acid, with that of tetraprenylacetone, a drug thought to be cytoprotective in the uppe ... Full text Link to item Cite

Corticotropin-releasing factor inhibits gastric emptying in dogs: studies on its mechanism of action.

Journal Article Peptides · 1987 Featured Publication The effects of corticotropin-releasing factor (CRF) on gastric emptying of a saline solution was further investigated in six dogs prepared with gastric fistulas and chronic cerebroventricular guides and in four other dogs with chronic gastric fistulas and ... Full text Link to item Cite

Peptide YY release by fatty acids is sufficient to inhibit gastric emptying in dogs.

Journal Article Gastroenterology · December 1986 Featured Publication Peptide YY is a candidate enterogastrone localized to endocrine cells of the ileocolonic mucosa. The purpose of the present study was to determine if blood levels of peptide YY observed after perfusion of the intestine with fatty acids are capable of slowi ... Full text Link to item Cite

The use of somatostatin and its analogs in the treatment of surgical disorders.

Journal Article Surgery · September 1986 Featured Publication Somatostatin is a naturally occurring peptide with a wide spectrum of biologic actions, most of which are inhibitory in nature. It has wide distribution, and within the gastrointestinal tract is is found in the pancreas, the stomach, intestinal mucosa, and ... Link to item Cite

Apparatus for long-term ventricular access in the awake canine.

Journal Article J Appl Physiol (1985) · July 1986 An apparatus is described that permits lateral ventricular cerebrospinal fluid (CSF) to be sampled or an infusion to be performed into the ventricular system in the awake canine. The device has been used in 25 dogs. CSF was sampled, and experiments involvi ... Full text Link to item Cite

Interactions of vasoactive intestinal polypeptide and cholecystokinin octapeptide on the control of gallbladder contraction.

Journal Article Surgery · April 1986 Featured Publication The gallbladder is supplied by three types of vagal fibers: cholinergic, cholecystokinin (CCK)-ergic, and vasoactive intestinal polypeptide (VIP)-ergic. Most previous studies on the interaction of VIP and CCK on gallbladder contraction have been in vitro. ... Link to item Cite

Enterogastrone-like effect of peptide YY is vagally mediated in the dog.

Journal Article J Clin Invest · January 1986 Featured Publication Intraluminal fat inhibits gastric secretion through as yet undetermined mechanisms which involve release of one or more hormonal enterogastrones. As intraluminal fat releases Peptide YY (PYY) in amounts sufficient to inhibit meal-stimulated acid secretion, ... Full text Link to item Cite

Effect of increased intracranial pressure on gastric acid secretion.

Journal Article Am J Surg · January 1986 Featured Publication The effects of intracranial pressure on gastric acid secretion were studied in 30 rabbits. Intracranial pressure was increased in a graded and controlled fashion using a barostat connected to a cannula in the lateral cerebral ventricle. Eighteen rabbits we ... Full text Link to item Cite

Calcitonin gene-related peptide-induced selective inhibition of gastric acid secretion in dogs.

Journal Article Am J Physiol · January 1986 Calcitonin gene-related peptide (CGRP) is a 37-residue peptide recently characterized in the brain and found in high concentrations in the gut, particularly in the stomach and pancreas. The effects of intravenous infusion of human and rat CGRP (260 pmol . ... Full text Link to item Cite

Cholecystokinin is not a peripheral satiety signal in the dog.

Journal Article Am J Physiol · December 1985 Featured Publication The doses of cholecystokinin (CCK) that have been shown to cause satiety after peripheral administration are pharmacological and whether "physiological" doses of exogenous CCK or endogenously released CCK have a satiety effect is not known. The purpose of ... Full text Link to item Cite

Peptide YY: metabolism and effect on pancreatic secretion in dogs.

Journal Article Gastroenterology · December 1985 Featured Publication Peptide YY is an ileocolonic peptide that inhibits meal-stimulated pancreatic secretion when infused in a dose of 400 pmol/kg X h. In this study pancreatic secretion was monitored in response to increasing doses of secretin or cholecystokinin-octapeptide ( ... Full text Link to item Cite

Opposing central and peripheral actions of brain-gut peptides: a basis for regulation of gastric function.

Journal Article Surgery · August 1985 Featured Publication The existence of an increasing number of peptides in both the gut and the brain provides the basis for the concept of a brain-gut axis. However, to date, no unifying hypothesis has been put forward to explain the physiologic significance of this remarkable ... Link to item Cite

Canine bombesin-like gastrin releasing peptides stimulate gastrin release and acid secretion in the dog.

Journal Article J Physiol · August 1985 Featured Publication The synthetic mammalian bombesin-like peptides, canine gastrin releasing peptide 27, 23 and 10, and porcine gastrin releasing peptide 27 were compared with amphibian bombesin 14 and 10 during intravenous infusions into six conscious dogs with chronic gastr ... Full text Link to item Cite

Corticotropin-releasing factor inhibits gastric emptying in dogs.

Journal Article Regul Pept · July 1985 The purpose of the present study was to evaluate the effect of ovine corticotropin-releasing factor (CRF) on the gastric emptying of a saline meal in conscious dogs. Intravenous infusion of CRF (220-880 pmol . kg-1 . h-1), induced a significant linear dose ... Full text Link to item Cite

Cerebroventricular bombesin inhibits gastric acid secretion in dogs.

Journal Article Gastroenterology · July 1985 Bolus injections of bombesin into a lateral cerebral ventricle of conscious beagle dogs inhibited pentagastrin-stimulated gastric acid secretion from both the innervated stomach (gastric fistula) and the vagally denervated Heidenhain pouch in a dose depend ... Full text Link to item Cite

Peptide YY inhibits meal-stimulated pancreatic and gastric secretion.

Journal Article Am J Physiol · January 1985 Featured Publication Peptide YY was recently isolated from porcine intestine and shown to exhibit marked structural homology with pancreatic polypeptide, a potent inhibitor of pancreatic exocrine secretion. We have examined the effects of infused peptide YY on gastric and panc ... Full text Link to item Cite

Adjunctive treatment of intestinal obstruction with somatostatin

Journal Article Surgical Forum · January 1, 1985 Cite

Spantide: failure to antagonize bombesin-induced stimulation of gastrin secretion in dogs.

Other Peptides · 1985 Featured Publication Spantide ([d-Arg1, d-Trp7,9, Leu11] substance P) was shown to function not only as a substance P receptor antagonist but also as a bombesin receptor antagonist. This study examined the effects of spantide on intravenous bombesin-induced stimulation of gast ... Full text Link to item Cite

Calcitonin gene-related peptide: potent peripheral inhibitor of gastric acid secretion in rats and dogs.

Journal Article Gastroenterology · August 1984 Calcitonin gene-related peptide is a 37-residue peptide recently characterized in central and peripheral nervous system. The pharmacologic or physiologic importance of this peptide is not known. We studied the effect of calcitonin gene-related peptide on e ... Link to item Cite

Adjustment Reactions and the Surgical Intern

Other JAMA: The Journal of the American Medical Association · July 2, 1982 Featured Publication Full text Cite

Pancreatitis-associated ascitic fluid: effect on the oxygen consumption of liver cells.

Journal Article Proc Soc Exp Biol Med · April 1982 Featured Publication Full text Link to item Cite

Electroconvulsive therapy does not change serum CK, LD, or LD isoenzymes.

Journal Article J Clin Psychiatry · April 1982 Featured Publication Link to item Cite

Effects of amino acids and gastric inhibitory polypeptide on insulin release in dogs.

Journal Article Am J Physiol · January 1982 Featured Publication Insulin release following intravenous administration of an amino acid solution with and without a simultaneous infusion of varying amounts of porcine gastric inhibitory polypeptide (GIP) was studied in dogs. Group I received a 10-amino acid mixture (300 mo ... Full text Link to item Cite

Effects of amino acids and gastric inhibitory polypeptide on insulin release in dogs

Journal Article American Journal of Physiology - Endocrinology and Metabolism · January 1, 1982 Insulin release following intravenous administration of an amino acid solution with and without a simultaneous infusion of varying amounts of porcine gastric inhibitory polypeptide (GIP) was studied in dogs. Group I received a 10-amino acid mixture (300 mo ... Cite

Pancreatic polypeptide in acute pancreatitis and small-bowel infarction in dogs.

Journal Article Dig Dis Sci · November 1981 Featured Publication Serum and urine concentrations of pancreatic polypeptide (PP) were measured during experimental acute hemorrhagic pancreatitis and small-bowel infarction in dogs. The mean serum PP concentration in animals with pancreatitis increased markedly after 1 hr an ... Full text Link to item Cite

Barbiturate-induced coma to protect against cerebral ischemia and increased intracranial pressure.

Journal Article Am J Hosp Pharm · April 1981 Featured Publication The use of barbiturates to induce coma as a means of extending the period of reversible cerebral ischemia is reviewed. Barbiturate use in patients who had had strokes or were undergoing aneurysm surgery was initially encouraging. In uncontrolled feasibilit ... Link to item Cite