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Yongmei Liu

Professor of Medicine
Medicine, Cardiology
300 N. Duke Street, Durham, NC 27701
Office hours By Appointment Only  

Selected Publications


Methylation patterns associated with C-reactive protein in racially and ethnically diverse populations.

Journal Article Epigenetics · December 2024 Systemic low-grade inflammation is a feature of chronic disease. C-reactive protein (CRP) is a common biomarker of inflammation and used as an indicator of disease risk; however, the role of inflammation in disease is not completely understood. Methylation ... Full text Link to item Cite

Transcriptome-wide association study of the plasma proteome reveals cis and trans regulatory mechanisms underlying complex traits.

Journal Article Am J Hum Genet · March 7, 2024 Regulation of transcription and translation are mechanisms through which genetic variants affect complex traits. Expression quantitative trait locus (eQTL) studies have been more successful at identifying cis-eQTL (within 1 Mb of the transcription start si ... Full text Link to item Cite

Causal association between snoring and stroke: a Mendelian randomization study in a Chinese population

Journal Article The Lancet Regional Health - Western Pacific · March 1, 2024 Background: Previous observational studies established a positive relationship between snoring and stroke. We aimed to investigate the causal effect of snoring on stroke. Methods: Based on 82,339 unrelated individuals with qualified genotyping data of Asia ... Full text Cite

Immune cells and related cytokines in dilated cardiomyopathy.

Journal Article Biomed Pharmacother · February 2024 Dilated cardiomyopathy (DCM) is a non-ischemic cardiomyopathy involving one or more underlying etiologies. It is characterized by structural and functional dysfunction of the myocardium, potentially leading to fibrosis and ventricular remodeling, and an el ... Full text Link to item Cite

Omicron BA.4/5 neutralization and cell-mediated immune responses in relation to baseline immune status and breakthrough infection among PLWH: A follow-up cohort study.

Journal Article J Med Virol · February 2024 There is a paucity of data on hybrid immunity (vaccination plus breakthrough infection [BI]), especially cell-mediated responses to Omicron among immunosuppressed patients. We aim to investigate humoral and cellular responses to Omicron BA.4/5 among people ... Full text Link to item Cite

Interaction molecular QTL mapping discovers cellular and environmental modifiers of genetic regulatory effects.

Journal Article Am J Hum Genet · January 4, 2024 Bulk-tissue molecular quantitative trait loci (QTLs) have been the starting point for interpreting disease-associated variants, and context-specific QTLs show particular relevance for disease. Here, we present the results of mapping interaction QTLs (iQTLs ... Full text Link to item Cite

Caloric Restriction Intervention Alters Specific Circulating Biomarkers of the Senescence-Associated Secretome in Middle-Aged and Older Adults With Obesity and Prediabetes in an 18-Week Randomized Controlled Trial.

Journal Article J Gerontol A Biol Sci Med Sci · January 1, 2024 Cellular senescence is a biological aging process that is exacerbated by obesity and leads to inflammation and age- and obesogenic-driven chronic diseases including type 2 diabetes. Caloric restriction (CR) may improve metabolic function in part by reducin ... Full text Link to item Cite

COVID-19 vaccination willingness among people living with HIV in Shijiazhuang, China: a cross-sectional survey

Journal Article Frontiers in Medicine · January 1, 2024 Objectives: The COVID-19 pandemic imposed an enormous disease and economic burden worldwide. SARS-CoV-2 vaccination is essential to containing the pandemic. People living with HIV (PLWH) may be more vulnerable to severe COVID-19 outcomes; thus, understandi ... Full text Cite

A wide landscape of morbidity and mortality risk associated with marital status in 0.5 million Chinese men and women: a prospective cohort study

Journal Article The Lancet Regional Health - Western Pacific · January 1, 2024 Background: A comprehensive depiction of long-term health impacts of marital status is lacking. Methods: Sex-stratified phenome-wide association analyses (PheWAS) of marital status (living with vs. without a spouse) were performed using baseline (2004–2008 ... Full text Cite

Bibliometric analysis of the global publication activity in the field of relapsing polychondritis during 1960-2023.

Journal Article Clin Rheumatol · December 2023 BACKGROUND: Relapsing polychondritis (RP) is an inflammatory disease with significant individual heterogeneity that involves systemic cartilage tissues. This study aimed to perform a bibliometric analysis of RP-related publications to quantitatively assess ... Full text Link to item Cite

Integrated analyses delineate distinctive immunological pathways and diagnostic signatures for Behcet's disease by leveraging gene microarray data.

Journal Article Immunol Res · December 2023 Behcet's disease (BD) is a chronic inflammatory vasculitis and clinically heterogeneous disorder caused by immunocyte aberrations. Comprehensive research on gene expression patterns in BD illuminating its aetiology is lacking. E-MTAB-2713 downloaded from A ... Full text Link to item Cite

Machine learning in TCM with natural products and molecules: current status and future perspectives

Journal Article Chinese Medicine (United Kingdom) · December 1, 2023 Traditional Chinese medicine (TCM) has been practiced for thousands of years with clinical efficacy. Natural products and their effective agents such as artemisinin and paclitaxel have saved millions of lives worldwide. Artificial intelligence is being inc ... Full text Cite

Negative serum (1,3) -β-D-glucan has a low power to exclude Pneumocystis jirovecii pneumonia (PJP) in HIV-uninfected patients with positive qPCR.

Journal Article Ann Clin Microbiol Antimicrob · November 20, 2023 OBJECTIVE: The current study evaluated the diagnostic performance of serum (1,3)-beta-D Glucan (BDG) in differentiating PJP from P. jirovecii-colonization in HIV-uninfected patients with P. jirovecii PCR-positive results. METHODS: This was a single-center ... Full text Link to item Cite

Associations of Early-Life Adversity With Later-Life Epigenetic Aging Profiles in the Multi-Ethnic Study of Atherosclerosis.

Journal Article Am J Epidemiol · November 10, 2023 Epigenetic biomarkers of accelerated aging have been widely used to predict disease risk and may enhance our understanding of biological mechanisms between early-life adversity and disparities in aging. With respect to childhood adversity, most studies hav ... Full text Link to item Cite

Methods for mediation analysis with high-dimensional DNA methylation data: Possible choices and comparisons.

Journal Article PLoS Genet · November 2023 Epigenetic researchers often evaluate DNA methylation as a potential mediator of the effect of social/environmental exposures on a health outcome. Modern statistical methods for jointly evaluating many mediators have not been widely adopted. We compare sev ... Full text Link to item Cite

Racial and Ethnic Residential Segregation and Monocyte DNA Methylation Age Acceleration.

Journal Article JAMA Netw Open · November 1, 2023 IMPORTANCE: Neighborhood segregation and poverty may be important drivers of health inequities. Epigenomic factors, including DNA methylation clocks that may mark underlying biological aging, have been implicated in the link between social factors and heal ... Full text Link to item Cite

Multi-ancestry epigenome-wide analyses identify methylated sites associated with aortic augmentation index in TOPMed MESA.

Journal Article Sci Rep · October 17, 2023 Despite the prognostic value of arterial stiffness (AS) and pulsatile hemodynamics (PH) for cardiovascular morbidity and mortality, epigenetic modifications that contribute to AS/PH remain unknown. To gain a better understanding of the link between epigene ... Full text Link to item Cite

Multivariate adaptive shrinkage improves cross-population transcriptome prediction and association studies in underrepresented populations.

Journal Article HGG Adv · October 12, 2023 Transcriptome prediction models built with data from European-descent individuals are less accurate when applied to different populations because of differences in linkage disequilibrium patterns and allele frequencies. We hypothesized that methods that le ... Full text Link to item Cite

The functional impact of rare variation across the regulatory cascade.

Journal Article Cell Genom · October 11, 2023 Each human genome has tens of thousands of rare genetic variants; however, identifying impactful rare variants remains a major challenge. We demonstrate how use of personal multi-omics can enable identification of impactful rare variants by using the Multi ... Full text Link to item Cite

Methylation patterns associated with C-reactive protein in racially and ethnically diverse populations.

Journal Article Epigenetics · December 2024 Systemic low-grade inflammation is a feature of chronic disease. C-reactive protein (CRP) is a common biomarker of inflammation and used as an indicator of disease risk; however, the role of inflammation in disease is not completely understood. Methylation ... Full text Link to item Cite

Transcriptome-wide association study of the plasma proteome reveals cis and trans regulatory mechanisms underlying complex traits.

Journal Article Am J Hum Genet · March 7, 2024 Regulation of transcription and translation are mechanisms through which genetic variants affect complex traits. Expression quantitative trait locus (eQTL) studies have been more successful at identifying cis-eQTL (within 1 Mb of the transcription start si ... Full text Link to item Cite

Causal association between snoring and stroke: a Mendelian randomization study in a Chinese population

Journal Article The Lancet Regional Health - Western Pacific · March 1, 2024 Background: Previous observational studies established a positive relationship between snoring and stroke. We aimed to investigate the causal effect of snoring on stroke. Methods: Based on 82,339 unrelated individuals with qualified genotyping data of Asia ... Full text Cite

Immune cells and related cytokines in dilated cardiomyopathy.

Journal Article Biomed Pharmacother · February 2024 Dilated cardiomyopathy (DCM) is a non-ischemic cardiomyopathy involving one or more underlying etiologies. It is characterized by structural and functional dysfunction of the myocardium, potentially leading to fibrosis and ventricular remodeling, and an el ... Full text Link to item Cite

Omicron BA.4/5 neutralization and cell-mediated immune responses in relation to baseline immune status and breakthrough infection among PLWH: A follow-up cohort study.

Journal Article J Med Virol · February 2024 There is a paucity of data on hybrid immunity (vaccination plus breakthrough infection [BI]), especially cell-mediated responses to Omicron among immunosuppressed patients. We aim to investigate humoral and cellular responses to Omicron BA.4/5 among people ... Full text Link to item Cite

Interaction molecular QTL mapping discovers cellular and environmental modifiers of genetic regulatory effects.

Journal Article Am J Hum Genet · January 4, 2024 Bulk-tissue molecular quantitative trait loci (QTLs) have been the starting point for interpreting disease-associated variants, and context-specific QTLs show particular relevance for disease. Here, we present the results of mapping interaction QTLs (iQTLs ... Full text Link to item Cite

Caloric Restriction Intervention Alters Specific Circulating Biomarkers of the Senescence-Associated Secretome in Middle-Aged and Older Adults With Obesity and Prediabetes in an 18-Week Randomized Controlled Trial.

Journal Article J Gerontol A Biol Sci Med Sci · January 1, 2024 Cellular senescence is a biological aging process that is exacerbated by obesity and leads to inflammation and age- and obesogenic-driven chronic diseases including type 2 diabetes. Caloric restriction (CR) may improve metabolic function in part by reducin ... Full text Link to item Cite

COVID-19 vaccination willingness among people living with HIV in Shijiazhuang, China: a cross-sectional survey

Journal Article Frontiers in Medicine · January 1, 2024 Objectives: The COVID-19 pandemic imposed an enormous disease and economic burden worldwide. SARS-CoV-2 vaccination is essential to containing the pandemic. People living with HIV (PLWH) may be more vulnerable to severe COVID-19 outcomes; thus, understandi ... Full text Cite

A wide landscape of morbidity and mortality risk associated with marital status in 0.5 million Chinese men and women: a prospective cohort study

Journal Article The Lancet Regional Health - Western Pacific · January 1, 2024 Background: A comprehensive depiction of long-term health impacts of marital status is lacking. Methods: Sex-stratified phenome-wide association analyses (PheWAS) of marital status (living with vs. without a spouse) were performed using baseline (2004–2008 ... Full text Cite

Bibliometric analysis of the global publication activity in the field of relapsing polychondritis during 1960-2023.

Journal Article Clin Rheumatol · December 2023 BACKGROUND: Relapsing polychondritis (RP) is an inflammatory disease with significant individual heterogeneity that involves systemic cartilage tissues. This study aimed to perform a bibliometric analysis of RP-related publications to quantitatively assess ... Full text Link to item Cite

Integrated analyses delineate distinctive immunological pathways and diagnostic signatures for Behcet's disease by leveraging gene microarray data.

Journal Article Immunol Res · December 2023 Behcet's disease (BD) is a chronic inflammatory vasculitis and clinically heterogeneous disorder caused by immunocyte aberrations. Comprehensive research on gene expression patterns in BD illuminating its aetiology is lacking. E-MTAB-2713 downloaded from A ... Full text Link to item Cite

Machine learning in TCM with natural products and molecules: current status and future perspectives

Journal Article Chinese Medicine (United Kingdom) · December 1, 2023 Traditional Chinese medicine (TCM) has been practiced for thousands of years with clinical efficacy. Natural products and their effective agents such as artemisinin and paclitaxel have saved millions of lives worldwide. Artificial intelligence is being inc ... Full text Cite

Negative serum (1,3) -β-D-glucan has a low power to exclude Pneumocystis jirovecii pneumonia (PJP) in HIV-uninfected patients with positive qPCR.

Journal Article Ann Clin Microbiol Antimicrob · November 20, 2023 OBJECTIVE: The current study evaluated the diagnostic performance of serum (1,3)-beta-D Glucan (BDG) in differentiating PJP from P. jirovecii-colonization in HIV-uninfected patients with P. jirovecii PCR-positive results. METHODS: This was a single-center ... Full text Link to item Cite

Associations of Early-Life Adversity With Later-Life Epigenetic Aging Profiles in the Multi-Ethnic Study of Atherosclerosis.

Journal Article Am J Epidemiol · November 10, 2023 Epigenetic biomarkers of accelerated aging have been widely used to predict disease risk and may enhance our understanding of biological mechanisms between early-life adversity and disparities in aging. With respect to childhood adversity, most studies hav ... Full text Link to item Cite

Methods for mediation analysis with high-dimensional DNA methylation data: Possible choices and comparisons.

Journal Article PLoS Genet · November 2023 Epigenetic researchers often evaluate DNA methylation as a potential mediator of the effect of social/environmental exposures on a health outcome. Modern statistical methods for jointly evaluating many mediators have not been widely adopted. We compare sev ... Full text Link to item Cite

Racial and Ethnic Residential Segregation and Monocyte DNA Methylation Age Acceleration.

Journal Article JAMA Netw Open · November 1, 2023 IMPORTANCE: Neighborhood segregation and poverty may be important drivers of health inequities. Epigenomic factors, including DNA methylation clocks that may mark underlying biological aging, have been implicated in the link between social factors and heal ... Full text Link to item Cite

Multi-ancestry epigenome-wide analyses identify methylated sites associated with aortic augmentation index in TOPMed MESA.

Journal Article Sci Rep · October 17, 2023 Despite the prognostic value of arterial stiffness (AS) and pulsatile hemodynamics (PH) for cardiovascular morbidity and mortality, epigenetic modifications that contribute to AS/PH remain unknown. To gain a better understanding of the link between epigene ... Full text Link to item Cite

Multivariate adaptive shrinkage improves cross-population transcriptome prediction and association studies in underrepresented populations.

Journal Article HGG Adv · October 12, 2023 Transcriptome prediction models built with data from European-descent individuals are less accurate when applied to different populations because of differences in linkage disequilibrium patterns and allele frequencies. We hypothesized that methods that le ... Full text Link to item Cite

The functional impact of rare variation across the regulatory cascade.

Journal Article Cell Genom · October 11, 2023 Each human genome has tens of thousands of rare genetic variants; however, identifying impactful rare variants remains a major challenge. We demonstrate how use of personal multi-omics can enable identification of impactful rare variants by using the Multi ... Full text Link to item Cite

Inactivated SARS-CoV-2 booster vaccine enhanced immune responses in patients with chronic liver diseases.

Journal Article Virol Sin · October 2023 Chronic liver disease (CLD) entails elevated risk of COVID-19 severity and mortality. The effectiveness of the booster dose of inactivated SARS-CoV-2 vaccine in stimulating antibody response in CLD patients is unclear. Therefore, we conducted a cross-secti ... Full text Link to item Cite

Chinese Herbal Medicine for the Treatment of Adult Viral Myocarditis: An Overview of Systematic Reviews and Meta-analyses of Randomized Controlled Trials.

Journal Article Clinical therapeutics · October 2023 PurposeViral myocarditis (VMC) is a life-threatening disease that can affect all ages and genders, with middle-aged adults being particularly susceptible. Numerous systematic reviews have been conducted to investigate the efficacy and safety of Ch ... Full text Cite

Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma.

Journal Article Cell Metab · September 5, 2023 Although many novel gene-metabolite and gene-protein associations have been identified using high-throughput biochemical profiling, systematic studies that leverage human genetics to illuminate causal relationships between circulating proteins and metaboli ... Full text Link to item Cite

Clinical effect of Astragalus membranaceus Injection on viral myocarditis in children: An overview of systematic reviews and evidence mapping

Journal Article Pharmacological Research - Modern Chinese Medicine · September 1, 2023 Objective: Viral myocarditis in children (VMCC) is a severe condition that requires effective treatment options. Astragalus membranaceus Injection (AMI) has been widely used for the treatment of VMCC and has shown promising results. In light of this, we co ... Full text Cite

Multiset correlation and factor analysis enables exploration of multi-omics data.

Journal Article Cell Genom · August 9, 2023 Multi-omics datasets are becoming more common, necessitating better integration methods to realize their revolutionary potential. Here, we introduce multi-set correlation and factor analysis (MCFA), an unsupervised integration method tailored to the unique ... Full text Link to item Cite

Systemic Markers of Lung Function and Forced Expiratory Volume in 1 Second Decline across Diverse Cohorts.

Conference Ann Am Thorac Soc · August 2023 Rationale: Chronic obstructive pulmonary disease (COPD) is a complex disease characterized by airway obstruction and accelerated lung function decline. Our understanding of systemic protein biomarkers associated with COPD remains incomplete. Objectives: To ... Full text Link to item Cite

SARS-CoV-2 Vaccine Uptake among Patients with Chronic Liver Disease: A Cross-Sectional Analysis in Hebei Province, China

Journal Article Vaccines · August 1, 2023 Chronic liver disease (CLD) patients have higher mortality and hospitalization rates after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aimed to explore SARS-CoV-2 vaccine perceptions, side effects, factors associ ... Full text Cite

Long-Term Exposure to Fine Particulate Matter and Incidence of Esophageal Cancer: A Prospective Study of 0.5 Million Chinese Adults.

Journal Article Gastroenterology · July 2023 BACKGROUND & AIMS: Evidence is sparse and inconclusive on the association between long-term fine (≤2.5 μm) particulate matter (PM2.5) exposure and esophageal cancer. We aimed to assess the association of PM2.5 with esophageal cancer risk and compared the e ... Full text Link to item Cite

Progress and challenges in the use of blood biomarkers in relapsing polychondritis.

Journal Article Clin Exp Immunol · June 5, 2023 Relapsing polychondritis (RP) is a rare inflammatory disease with significant individual heterogeneity that involves systemic organs. The diagnosis of RP mainly depends on the clinical manifestations; currently, there are no molecular biomarkers routinely ... Full text Link to item Cite

Infectious agents and pathogenesis of Behçet's disease: An extensive review.

Journal Article Clin Immunol · June 2023 Behçet's disease (BD) is a multisystemic chronic vasculitis. Sustained and enhanced immune responses were reportedly associated with active BD. Although genetic polymorphisms increase development risk, genetic factors alone cannot account for BD developmen ... Full text Link to item Cite

Potential of natural products in combination with arsenic trioxide: Investigating cardioprotective effects and mechanisms.

Journal Article Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · June 2023 Over the past few decades, clinical trials conducted worldwide have demonstrated the efficacy of arsenic trioxide (ATO) in the treatment of relapsed acute promyelocytic leukemia (APL). Currently, ATO has become the frontline treatments for patients with AP ... Full text Cite

DNA methylation analysis is used to identify novel genetic loci associated with circulating fibrinogen levels in blood.

Journal Article Journal of thrombosis and haemostasis : JTH · May 2023 BackgroundFibrinogen plays an essential role in blood coagulation and inflammation. Circulating fibrinogen levels may be determined based on interindividual differences in DNA methylation at cytosine-phosphate-guanine (CpG) sites and vice versa. Full text Cite

Canonical correlation analysis for multi-omics: Application to cross-cohort analysis.

Journal Article PLoS Genet · May 2023 Integrative approaches that simultaneously model multi-omics data have gained increasing popularity because they provide holistic system biology views of multiple or all components in a biological system of interest. Canonical correlation analysis (CCA) is ... Full text Link to item Cite

Myelin basic protein and index for neuro-Behçet's disease.

Journal Article Clin Immunol · May 2023 Neuro-Behçet's disease (NBD) contributes to poor prognosis in BD patients which lacks reliable laboratory biomarkers in assessing intrathecal injury. This study aimed to determine the diagnostic value of myelin basic protein (MBP), an indicator of central ... Full text Link to item Cite

Single-cell analysis of adult human heart across healthy and cardiovascular disease patients reveals the cellular landscape underlying SARS-CoV-2 invasion of myocardial tissue through ACE2.

Journal Article Journal of translational medicine · May 2023 BackgroundThe distribution of ACE2 and accessory proteases (ANAD17 and CTSL) in cardiovascular tissue and the host cell receptor binding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are crucial to understanding the virus's cell ... Full text Cite

Healthy lifestyle, DNA methylation age acceleration, and incident risk of coronary heart disease.

Journal Article Clin Epigenetics · March 28, 2023 BACKGROUND: DNA methylation clocks emerged as a tool to determine biological aging and have been related to mortality and age-related diseases. Little is known about the association of DNA methylation age (DNAm age) with coronary heart disease (CHD), espec ... Full text Link to item Cite

Methods for large-scale single mediator hypothesis testing: Possible choices and comparisons.

Journal Article Genet Epidemiol · March 2023 Mediation hypothesis testing for a large number of mediators is challenging due to the composite structure of the null hypothesis, H 0 : α β = 0 ${H}_{0}:\alpha \beta =0$ ( α $\alpha $ : effect of the exposure on the mediator after adjusting for confo ... Full text Link to item Cite

Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity.

Journal Article Stroke · March 2023 BACKGROUND: Recently, common genetic risk factors for intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (ASAH) were found to explain a large amount of disease heritability and therefore have potential to be used for genetic risk prediction. ... Full text Link to item Cite

Modeling biological age using blood biomarkers and physical measurements in Chinese adults.

Journal Article EBioMedicine · March 2023 BACKGROUND: This study aimed to: 1) assess the associations of biological age acceleration based on Klemera and Doubal's method (KDM-AA) with long-term risk of all-cause mortality; and 2) compare the association of KDM-AA with all-cause mortality among par ... Full text Link to item Cite

Circulating VEGF-A, TNF-α, CCL2, IL-6, and IFN-γ as biomarkers of cancer in cancer-associated anti-TIF1-γ antibody-positive dermatomyositis.

Journal Article Clin Rheumatol · March 2023 OBJECTIVES: The objective of the current study was to detect plasma profiles of inflammatory cytokines for determining potential biomarkers indicating cancer presence among the anti-TIF1-γ antibody-positive dermatomyositis (DM) patients. METHODS: Twenty-se ... Full text Link to item Cite

The association between aging-related monocyte transcriptional networks and comorbidity burden: the Multi-Ethnic Study of Atherosclerosis (MESA).

Journal Article Geroscience · February 2023 Translating our knowledge of the biological aging from animal models to humans may give rise to novel approaches of targeting multiple aging-related diseases simultaneously and increasing health span. Here, for the first time, we use transcriptomic signatu ... Full text Link to item Cite

Gene expression associations with body mass index in the Multi-Ethnic Study of Atherosclerosis.

Journal Article Int J Obes (Lond) · February 2023 BACKGROUND/OBJECTIVES: Obesity, defined as excessive fat accumulation that represents a health risk, is increasing in adults and children, reaching global epidemic proportions. Body mass index (BMI) correlates with body fat and future health risk, yet diff ... Full text Link to item Cite

Distinct COPD subtypes in former smokers revealed by gene network perturbation analysis.

Journal Article Respir Res · January 25, 2023 BACKGROUND: Chronic obstructive pulmonary disease (COPD) varies significantly in symptomatic and physiologic presentation. Identifying disease subtypes from molecular data, collected from easily accessible blood samples, can help stratify patients and guid ... Full text Link to item Cite

Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies.

Journal Article Nat Genet · January 2023 Meta-analysis of whole genome sequencing/whole exome sequencing (WGS/WES) studies provides an attractive solution to the problem of collecting large sample sizes for discovering rare variants associated with complex phenotypes. Existing rare variant meta-a ... Full text Open Access Link to item Cite

Transcriptome-wide association study identifies new susceptibility genes for degenerative cervical spondylosis

Journal Article Bone and Joint Research · January 1, 2023 Aims Degenerative cervical spondylosis (DCS) is a common musculoskeletal disease that encompasses a wide range of progressive degenerative changes and affects all components of the cervical spine. DCS imposes very large social and economic burdens. However ... Full text Cite

Plasma lipidomics of primary biliary cholangitis and its comparison with Sjögren's syndrome.

Journal Article Front Immunol · 2023 BACKGROUND: Abnormal lipid metabolism is common in patients with primary biliary cholangitis (PBC). PBC and Sjögren's syndrome (SS) frequently coexist in clinical practice; however, the lipid characteristics of both diseases are unknown. Therefore, we aime ... Full text Link to item Cite

COVID-19 vaccination status, side effects, and perceptions among breast cancer survivors: a cross-sectional study in China.

Journal Article Front Public Health · 2023 INTRODUCTION: Breast cancer is the most prevalent malignancy in patients with coronavirus disease 2019 (COVID-19). However, vaccination data of this population are limited. METHODS: A cross-sectional study of COVID-19 vaccination was conducted in China. Mu ... Full text Link to item Cite

Booster shot of inactivated SARS-CoV-2 vaccine induces potent immune responses in people living with HIV.

Journal Article J Med Virol · January 2023 This study aimed to investigate the immunogenicity to SARS-CoV-2 and evasive subvariants BA.4/5 in people living with HIV (PLWH) following a third booster shot of inactivated SARS-CoV-2 vaccine. We conducted a cross-sectional study in 318 PLWH and 241 heal ... Full text Link to item Cite

Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci.

Journal Article Front Genet · 2023 Introduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes. Methods: A two-stage genome-wide meta-analysis of low-density lipoprotein cholesterol (LDL ... Full text Link to item Cite

Development and validation of diagnostic and activity-assessing models for relapsing polychondritis based on laboratory parameters.

Journal Article Front Immunol · 2023 BACKGROUND: Relapsing polychondritis (RP) as a rare autoimmune disease is characterized by recurrent inflammation of the organs containing cartilage. Currently, no biomarkers have been integrated into clinical practice. This study aimed to construct and ev ... Full text Link to item Cite

Identification and analysis of differential miRNA–mRNA interactions in coronary heart disease: an experimental screening approach

Journal Article Frontiers in Cardiovascular Medicine · January 1, 2023 Objective: This aim of this study is to screen the differential molecules of kidney deficiency and blood stasis (KDBS) syndrome in coronary heart disease by high-throughput sequencing. In addition, the study aims to verify the alterations in the expression ... Full text Cite

Trained immunity in monocyte/macrophage: Novel mechanism of phytochemicals in the treatment of atherosclerotic cardiovascular disease

Journal Article Frontiers in Pharmacology · January 1, 2023 Atherosclerosis (AS) is the pathology of atherosclerotic cardiovascular diseases (ASCVD), characterized by persistent chronic inflammation in the vessel wall, in which monocytes/macrophages play a key role. It has been reported that innate immune system ce ... Full text Cite

Visualization of mTOR Pathway Regulated by Traditional Chinese Medicine: A Bibliometric Analysis Based on Multiple Software

Journal Article Chinese Journal of Experimental Traditional Medical Formulae · January 1, 2023 Objective:To summarize the research progress of mammalian target of rapamycin(mTOR)pathway regulated by traditional Chinese medicine(TCM) and provide reference for visualization and quantitative analysis of related research based on multiple software linka ... Full text Cite

Knowledge Graph Construction of Coronary Heart Disease Based on Traditional Chinese Medicine Diagnosis and Treatment Guidelines

Journal Article Chinese Journal of Experimental Traditional Medical Formulae · January 1, 2023 Objective: To construct the syndrome differentiation and treatment process in the diagnosis and treatment guideline into a visual knowledge graph using knowledge graph technology,and visualize the process from the input of clinical manifestations to the ou ... Full text Cite

Functional compounds of ginseng and ginseng-containing medicine for treating cardiovascular diseases

Journal Article Frontiers in Pharmacology · December 2, 2022 Ginseng (Panax ginseng C.A.Mey.) is the dry root and rhizome of the Araliaceae ginseng plant. It has always been used as a tonic in China for strengthening the body. Cardiovascular disease is still the main cause of death in the world. Some studies have sh ... Full text Cite

miR194 hypomethylation regulates coronary artery disease pathogenesis.

Journal Article BMC medical genomics · December 2022 Coronary artery disease (CAD) is one of the most common heart diseases, characterized by the hardening and narrowing of arteries, resisting blood supply to cardiac muscle. Despite extensive research, the pathogenesis and therapeutic options for CAD remain ... Full text Cite

Exploring the “gene–protein–metabolite” network of coronary heart disease with phlegm and blood stasis syndrome by integrated multi-omics strategy

Journal Article Frontiers in Pharmacology · November 29, 2022 Background: According to the theory of traditional Chinese medicine, phlegm and blood stasis (PBS) is the pathological basis for coronary heart disease (CHD). This study aimed to explore the biological basis of PBS syndrome in CHD. Methods: Using a strateg ... Full text Cite

Targeted Genome Sequencing Identifies Multiple Rare Variants in Caveolin-1 Associated with Obstructive Sleep Apnea.

Journal Article Am J Respir Crit Care Med · November 15, 2022 Rationale: Obstructive sleep apnea (OSA) is a common disorder associated with increased risk for cardiovascular disease, diabetes, and premature mortality. There is strong clinical and epidemiologic evidence supporting the importance of genetic factors inf ... Full text Link to item Cite

Roles of biomarkers in anti-MDA5-positive dermatomyositis, associated interstitial lung disease, and rapidly progressive interstitial lung disease.

Journal Article J Clin Lab Anal · November 2022 BACKGROUND: Anti-melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis (MDA5+ DM) is significantly associated with interstitial lung disease (ILD), especially rapidly progressive ILD (RPILD) due to poor prognosis, resulting in high mor ... Full text Link to item Cite

Whole genome sequence analysis of blood lipid levels in >66,000 individuals.

Journal Article Nat Commun · October 11, 2022 Blood lipids are heritable modifiable causal factors for coronary artery disease. Despite well-described monogenic and polygenic bases of dyslipidemia, limitations remain in discovery of lipid-associated alleles using whole genome sequencing (WGS), partly ... Full text Open Access Link to item Cite

Differences in Metabolomic Profiles Between Black and White Women and Risk of Coronary Heart Disease: an Observational Study of Women From Four US Cohorts.

Journal Article Circ Res · September 16, 2022 BACKGROUND: Racial differences in metabolomic profiles may reflect underlying differences in social determinants of health by self-reported race and may be related to racial disparities in coronary heart disease (CHD) among women in the United States. Howe ... Full text Link to item Cite

The Role of Epigenetic Clocks in Explaining Educational Inequalities in Mortality: A Multicohort Study and Meta-analysis.

Journal Article J Gerontol A Biol Sci Med Sci · September 1, 2022 Educational inequalities in all-cause mortality have been observed for decades. However, the underlying biological mechanisms are not well known. We aimed to assess the role of DNA methylation changes in blood captured by epigenetic clocks in explaining th ... Full text Link to item Cite

Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.

Journal Article Nat Commun · September 1, 2022 The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular a ... Full text Link to item Cite

Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals.

Journal Article Nat Commun · August 22, 2022 Integrating genetic information with metabolomics has provided new insights into genes affecting human metabolism. However, gene-metabolite integration has been primarily studied in individuals of European Ancestry, limiting the opportunity to leverage gen ... Full text Link to item Cite

Pulmonary Function and Blood DNA Methylation: A Multiancestry Epigenome-Wide Association Meta-analysis.

Journal Article Am J Respir Crit Care Med · August 1, 2022 Rationale: Methylation integrates factors present at birth and modifiable across the lifespan that can influence pulmonary function. Studies are limited in scope and replication. Objectives: To conduct large-scale epigenome-wide meta-analyses of blood DNA ... Full text Link to item Cite

Arsenic Exposure, Blood DNA Methylation, and Cardiovascular Disease.

Journal Article Circ Res · July 8, 2022 BACKGROUND: Epigenetic dysregulation has been proposed as a key mechanism for arsenic-related cardiovascular disease (CVD). We evaluated differentially methylated positions (DMPs) as potential mediators on the association between arsenic and CVD. METHODS: ... Full text Link to item Cite

Genetic interactions drive heterogeneity in causal variant effect sizes for gene expression and complex traits.

Journal Article Am J Hum Genet · July 7, 2022 Despite the growing number of genome-wide association studies (GWASs), it remains unclear to what extent gene-by-gene and gene-by-environment interactions influence complex traits in humans. The magnitude of genetic interactions in complex traits has been ... Full text Link to item Cite

Panax notoginseng Saponins Alleviate Coronary Artery Disease Through Hypermethylation of the miR-194-MAPK Pathway

Journal Article Frontiers in Pharmacology · June 16, 2022 Background: Panax notoginseng saponins (PNS) may have an inhibitory effect against coronary artery disease (CAD); however, the mechanism is unclear. Recent research has begun to evaluate the role of epigenetics in CAD. Our team found that hypomethylation o ... Full text Cite

Coarse Grain Consumption and Risk of Cardiometabolic Diseases: A Prospective Cohort Study of Chinese Adults.

Journal Article J Nutr · June 9, 2022 BACKGROUND: Lower consumption of whole grains is associated with higher risks of diabetes and coronary heart disease in Western populations, but evidence is still limited for stroke. Moreover, little is known in China, where the rates of cardiometabolic di ... Full text Link to item Cite

The Socioeconomic Gradient in Epigenetic Ageing Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study.

Journal Article Epigenetics · June 2022 Epigenetic clocks have been widely used to predict disease risk in multiple tissues or cells. Their success as a measure of biological ageing has prompted research on the connection between epigenetic pathways of ageing and the socioeconomic gradient in he ... Full text Cite

Mechanism of Cordyceps in Treating Bronchial Asthma and Chronic Renal Failure with Concept of”Same Treatment for Different Diseases” Based on Network Pharmacology and Molecular Docking Technology

Journal Article Chinese Journal of Experimental Traditional Medical Formulae · June 1, 2022 Objective: To explore the mechanism of Cordyceps in treating bronchial asthma and chronic renal failure with the concept of “same treatment for different diseases” in traditional Chinese medicine(TCM) by network pharmacology and molecular docking technolog ... Full text Cite

Lymphocyte activation gene-3-associated protein networks are associated with HDL-cholesterol and mortality in the Trans-omics for Precision Medicine program.

Journal Article Commun Biol · May 2, 2022 Deficiency of the immune checkpoint lymphocyte activation gene-3 (LAG3) protein is significantly associated with both elevated HDL-cholesterol (HDL-C) and myocardial infarction risk. We determined the association of genetic variants within ±500 kb of LAG3 ... Full text Link to item Cite

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.

Journal Article Nature genetics · May 2022 We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic associa ... Full text Cite

Monocyte miRNAs Are Associated With Type 2 Diabetes.

Journal Article Diabetes · April 1, 2022 miRNAs are small noncoding RNAs that may contribute to common diseases through epigenetic regulation of gene expression. Little is known regarding the role of miRNAs in type 2 diabetes (T2D). We performed miRNA sequencing and transcriptomic profiling of pe ... Full text Link to item Cite

Importance of healthy lifestyle factors and ideal cardiovascular health metrics for risk of heart failure in Chinese adults

Journal Article International Journal of Epidemiology · April 1, 2022 Background: The relative importance of healthy lifestyle factors and cardiovascular health metrics for the risk of heart failure is uncertain in Chinese populations. We aimed to compare the strength of associations between healthy lifestyle factors and ide ... Full text Cite

Lifestyle factors and fetal and childhood origins of type 2 diabetes: a prospective study of Chinese and European adults.

Journal Article Am J Clin Nutr · March 4, 2022 BACKGROUND: Early-life development plays a key role in adult type 2 diabetes (T2D), but the extent to which this can be attenuated by lifestyle is unknown. OBJECTIVES: The aim was to investigate the independent relevance of genetic predisposition to low bi ... Full text Link to item Cite

Epigenome-wide analysis of long-term air pollution exposure and DNA methylation in monocytes: results from the Multi-Ethnic Study of Atherosclerosis.

Journal Article Epigenetics · March 2022 Air pollution might affect atherosclerosis through DNA methylation changes in cells crucial to atherosclerosis, such as monocytes. We conducted an epigenome-wide study of DNA methylation in CD14+ monocytes and long-term ambient air pollution exposure in ad ... Full text Link to item Cite

Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data.

Journal Article Nat Genet · March 2022 Analyses of data from genome-wide association studies on unrelated individuals have shown that, for human traits and diseases, approximately one-third to two-thirds of heritability is captured by common SNPs. However, it is not known whether the remaining ... Full text Link to item Cite

Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights Into Cardiovascular Disease.

Journal Article Circulation · February 2022 BACKGROUND: Plasma proteins are critical mediators of cardiovascular processes and are the targets of many drugs. Previous efforts to characterize the genetic architecture of the plasma proteome have been limited by a focus on individuals of European desce ... Full text Link to item Cite

Upregulated heme biosynthesis increases obstructive sleep apnea severity: a pathway-based Mendelian randomization study.

Journal Article Sci Rep · January 27, 2022 Obstructive sleep apnea (OSA) is a common disorder associated with increased risk of cardiovascular disease and mortality. Iron and heme metabolism, implicated in ventilatory control and OSA comorbidities, was associated with OSA phenotypes in recent admix ... Full text Link to item Cite

AtheroSpectrum Reveals Novel Macrophage Foam Cell Gene Signatures Associated With Atherosclerotic Cardiovascular Disease Risk.

Journal Article Circulation · January 18, 2022 BACKGROUND: Whereas several interventions can effectively lower lipid levels in people at risk for atherosclerotic cardiovascular disease (ASCVD), cardiovascular event risks remain, suggesting an unmet medical need to identify factors contributing to cardi ... Full text Link to item Cite

Protein prediction for trait mapping in diverse populations.

Journal Article PLoS One · 2022 Genetically regulated gene expression has helped elucidate the biological mechanisms underlying complex traits. Improved high-throughput technology allows similar interrogation of the genetically regulated proteome for understanding complex trait mechanism ... Full text Link to item Cite

DNA Methylation Mediates the Association Between Individual and Neighborhood Social Disadvantage and Cardiovascular Risk Factors.

Journal Article Front Cardiovasc Med · 2022 Low socioeconomic status (SES) and living in a disadvantaged neighborhood are associated with poor cardiovascular health. Multiple lines of evidence have linked DNA methylation to both cardiovascular risk factors and social disadvantage indicators. However ... Full text Link to item Cite

Alterations of m6A RNA methylation regulators contribute to autophagy and immune infiltration in primary Sjögren's syndrome.

Journal Article Front Immunol · 2022 N6-methyladenosine (m6A) RNA modification is a new epigenetic regulation mechanism on eukaryotic mRNA. Few autoimmune diseases focused on the role of m6A in their pathogenies, and m6A modulation in the pathological process of primary Sjögren's syndrome (pS ... Full text Link to item Cite

The Roles of Noncoding RNAs in Systemic Sclerosis.

Journal Article Front Immunol · 2022 Noncoding RNAs (ncRNAs) constitute more than 90% of the RNAs in the human genome. In the past decades, studies have changed our perception of ncRNAs from "junk" transcriptional products to functional regulatory molecules that mediate critical processes, in ... Full text Link to item Cite

Modified Banxia Xiexin Decoction Ameliorates Polycystic Ovarian Syndrome With Insulin Resistance by Regulating Intestinal Microbiota.

Journal Article Frontiers in cellular and infection microbiology · January 2022 ObjectiveTo analyze the characteristics of the intestinal microbiota of polycystic ovarian syndrome with insulin resistance (PCOS-IR) and explore the possible mechanism of modified Banxia Xiexin Decoction in the treatment of PCOS-IR.Methods Full text Cite

Effects of Bushen-Jiangya granules on blood pressure and pharmacogenomic evaluation in low-to-medium-risk hypertensive patients: study protocol for a randomized double-blind controlled trial.

Journal Article Trials · January 2022 IntroductionHypertension is one of the most important risk factors for cardiovascular disease, and its control rates remain low worldwide. The most effective strategy is that patients with hypertension should be diagnosed and treated early. Prelim ... Full text Cite

Epigenome-wide association study of mitochondrial genome copy number.

Journal Article Hum Mol Genet · December 27, 2021 We conducted cohort- and race-specific epigenome-wide association analyses of mitochondrial deoxyribonucleic acid (mtDNA) copy number (mtDNA CN) measured in whole blood from participants of African and European origins in five cohorts (n = 6182, mean age = ... Full text Link to item Cite

Associations between DNA methylation and BMI vary by metabolic health status: a potential link to disparate cardiovascular outcomes.

Journal Article Clin Epigenetics · December 22, 2021 BACKGROUND: Body mass index (BMI), a well-known risk factor for poor cardiovascular outcomes, is associated with differential DNA methylation (DNAm). Similarly, metabolic health has also been associated with changes in DNAm. It is unclear how overall metab ... Full text Link to item Cite

Meta-analyses identify DNA methylation associated with kidney function and damage.

Journal Article Nat Commun · December 9, 2021 Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease. To extend the knowledge on regulatory mechanisms related to kidney fu ... Full text Link to item Cite

Associations of toothbrushing behaviour with risks of vascular and nonvascular diseases in Chinese adults.

Journal Article Eur J Clin Invest · December 2021 Accumulating evidence has shown that poor oral hygiene is associated with increased risk of cardiometabolic diseases in Western populations. However, its relevance about the relationships in Chinese adults remains unclear. The China Kadoorie Biobank enroll ... Full text Link to item Cite

Bayesian hierarchical models for high-dimensional mediation analysis with coordinated selection of correlated mediators.

Journal Article Stat Med · November 30, 2021 We consider Bayesian high-dimensional mediation analysis to identify among a large set of correlated potential mediators the active ones that mediate the effect from an exposure variable to an outcome of interest. Correlations among mediators are commonly ... Full text Link to item Cite

Identification of Two Long Non-Coding RNAs AC010082.1 and AC011443.1 as Biomarkers of Coronary Heart Disease Based on Logistic Stepwise Regression Prediction Model

Journal Article Frontiers in Genetics · November 18, 2021 Coronary heart disease (CHD) is a global health concern with high morbidity and mortality rates. This study aimed to identify the possible long non-coding RNA (lncRNA) biomarkers of CHD. The lncRNA- and mRNA-related data of patients with CHD were downloade ... Full text Cite

Benchmarking association analyses of continuous exposures with RNA-seq in observational studies.

Journal Article Brief Bioinform · November 5, 2021 Large datasets of hundreds to thousands of individuals measuring RNA-seq in observational studies are becoming available. Many popular software packages for analysis of RNA-seq data were constructed to study differences in expression signatures in an exper ... Full text Link to item Cite

Role of DNA methylation on the association between physical activity and cardiovascular diseases: results from the longitudinal multi-ethnic study of atherosclerosis (MESA) cohort.

Journal Article BMC Genomics · November 3, 2021 BACKGROUND: The complexity of physical activity (PA) and DNA methylation interaction in the development of cardiovascular disease (CVD) is rarely simultaneously investigated in one study. We examined the role of DNA methylation on the association between P ... Full text Link to item Cite

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.

Journal Article Mol Psychiatry · November 2021 Long and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the genetic basis of sleep-related BP variation, we ... Full text Link to item Cite

Bayesian Sparse Mediation Analysis with Targeted Penalization of Natural Indirect Effects.

Journal Article J R Stat Soc Ser C Appl Stat · November 2021 Causal mediation analysis aims to characterize an exposure's effect on an outcome and quantify the indirect effect that acts through a given mediator or a group of mediators of interest. With the increasing availability of measurements on a large number of ... Full text Link to item Cite

A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.

Journal Article Nat Genet · October 2021 Fine-mapping to plausible causal variation may be more effective in multi-ancestry cohorts, particularly in the MHC, which has population-specific structure. To enable such studies, we constructed a large (n = 21,546) HLA reference panel spanning five glob ... Full text Link to item Cite

Modification effect of ideal cardiovascular health metrics on genetic association with incident heart failure in the China Kadoorie Biobank and the UK Biobank.

Journal Article BMC medicine · October 2021 BackgroundBoth genetic and cardiovascular factors contribute to the risk of developing heart failure (HF), but whether idea cardiovascular health metrics (ICVHMs) offset the genetic association with incident HF remains unclear.ObjectivesT ... Full text Cite

Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function.

Journal Article Sci Rep · September 29, 2021 Genome-wide association studies have identified numerous common genetic variants associated with spirometric measures of pulmonary function, including forced expiratory volume in one second (FEV1), forced vital capacity, and their ratio. However, variants ... Full text Link to item Cite

Utility of single versus sequential measurements of risk factors for prediction of stroke in Chinese adults.

Journal Article Sci Rep · September 2, 2021 Absolute risks of stroke are typically estimated using measurements of cardiovascular disease risk factors recorded at a single visit. However, the comparative utility of single versus sequential risk factor measurements for stroke prediction is unclear. R ... Full text Link to item Cite

Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.

Journal Article Genome Med · August 26, 2021 BACKGROUND: Sleep-disordered breathing is a common disorder associated with significant morbidity. The genetic architecture of sleep-disordered breathing remains poorly understood. Through the NHLBI Trans-Omics for Precision Medicine (TOPMed) program, we p ... Full text Link to item Cite

Contrasting effects of Western vs Mediterranean diets on monocyte inflammatory gene expression and social behavior in a primate model.

Journal Article Elife · August 2, 2021 Dietary changes associated with industrialization increase the prevalence of chronic diseases, such as obesity, type II diabetes, and cardiovascular disease. This relationship is often attributed to an 'evolutionary mismatch' between human physiology and m ... Full text Link to item Cite

Genetic insights into biological mechanisms governing human ovarian ageing.

Journal Article Nature · August 2021 Reproductive longevity is essential for fertility and influences healthy ageing in women1,2, but insights into its underlying biological mechanisms and treatments to preserve it are limited. Here we identify 290 genetic determinants of ovarian ageing, asse ... Full text Link to item Cite

Association of heart rate and diabetes among 0.5 million adults in the China Kadoorie biobank: Results from observational and Mendelian randomization analyses.

Journal Article Nutr Metab Cardiovasc Dis · July 22, 2021 BACKGROUND AND AIMS: Observational studies have associated resting heart rate with incident diabetes. Whether the associations are causal remains unclear. We aimed to examine the shape and strength of the associations and assessed the causal relevance of s ... Full text Link to item Cite

Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations.

Journal Article Genes (Basel) · July 8, 2021 BACKGROUND: Thousands of genetic variants have been associated with hematological traits, though target genes remain unknown at most loci. Moreover, limited analyses have been conducted in African ancestry and Hispanic/Latino populations; hematological tra ... Full text Link to item Cite

Genome sequencing unveils a regulatory landscape of platelet reactivity.

Journal Article Nat Commun · June 15, 2021 Platelet aggregation at the site of atherosclerotic vascular injury is the underlying pathophysiology of myocardial infarction and stroke. To build upon prior GWAS, here we report on 16 loci identified through a whole genome sequencing (WGS) approach in 3, ... Full text Link to item Cite

Variant-specific inflation factors for assessing population stratification at the phenotypic variance level.

Journal Article Nat Commun · June 9, 2021 In modern Whole Genome Sequencing (WGS) epidemiological studies, participant-level data from multiple studies are often pooled and results are obtained from a single analysis. We consider the impact of differential phenotype variances by study, which we te ... Full text Link to item Cite

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.

Journal Article Molecular psychiatry · June 2021 Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educationa ... Full text Cite

Clonal hematopoiesis associated with epigenetic aging and clinical outcomes.

Journal Article Aging Cell · June 2021 Clonal hematopoiesis of indeterminate potential (CHIP) is a common precursor state for blood cancers that most frequently occurs due to mutations in the DNA-methylation modifying enzymes DNMT3A or TET2. We used DNA-methylation array and whole-genome sequen ... Full text Link to item Cite

Development and external validation of a breast cancer absolute risk prediction model in Chinese population.

Journal Article Breast Cancer Res · May 29, 2021 BACKGROUNDS: In contrast to developed countries, breast cancer in China is characterized by a rapidly escalating incidence rate in the past two decades, lower survival rate, and vast geographic variation. However, there is no validated risk prediction mode ... Full text Link to item Cite

Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci.

Journal Article Genome Med · April 30, 2021 BACKGROUND: DNA methylation (DNAm) is associated with gene regulation and estimated glomerular filtration rate (eGFR), a measure of kidney function. Decreased eGFR is more common among US Hispanics and African Americans. The causes for this are poorly unde ... Full text Open Access Link to item Cite

Genome-wide association study of circulating interleukin 6 levels identifies novel loci.

Journal Article Hum Mol Genet · April 27, 2021 Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesi ... Full text Link to item Cite

Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium.

Journal Article Genome Med · April 21, 2021 BACKGROUND: The large airway epithelial barrier provides one of the first lines of defense against respiratory viruses, including SARS-CoV-2 that causes COVID-19. Substantial inter-individual variability in individual disease courses is hypothesized to be ... Full text Link to item Cite

Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices.

Journal Article Nat Commun · April 12, 2021 Autosomal genetic analyses of blood lipids have yielded key insights for coronary heart disease (CHD). However, X chromosome genetic variation is understudied for blood lipids in large sample sizes. We now analyze genetic and blood lipid data in a high-cov ... Full text Link to item Cite

Transcriptome prediction performance across machine learning models and diverse ancestries.

Journal Article HGG Adv · April 8, 2021 Transcriptome prediction methods such as PrediXcan and FUSION have become popular in complex trait mapping. Most transcriptome prediction models have been trained in European populations using methods that make parametric linear assumptions like the elasti ... Full text Link to item Cite

Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry.

Journal Article Am J Hum Genet · April 1, 2021 Although many loci have been associated with height in European ancestry populations, very few have been identified in African ancestry individuals. Furthermore, many of the known loci have yet to be generalized to and fine-mapped within a large-scale Afri ... Full text Link to item Cite

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program.

Journal Article Nature · February 2021 The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of improving diagnosis, treatment and prevention of these diseases. The init ... Full text Link to item Cite

Multi-Ancestry Genome-wide Association Study Accounting for Gene-Psychosocial Factor Interactions Identifies Novel Loci for Blood Pressure Traits.

Journal Article HGG Adv · January 14, 2021 Psychological and social factors are known to influence blood pressure (BP) and risk of hypertension and associated cardiovascular diseases. To identify novel BP loci, we carried out genome-wide association meta-analyses of systolic, diastolic, pulse, and ... Full text Link to item Cite

Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.

Journal Article Nat Commun · January 5, 2021 Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic compone ... Full text Link to item Cite

Molecular Mechanism of Modified Guizhi Fulingwan Intervention on Uterine Fibroids in Rats Based on micRNA Expression Profiling

Journal Article Chinese Journal of Experimental Traditional Medical Formulae · January 1, 2021 Objective: To explore the molecular mechanism of modified Guizhi Fulingwan in rats with uterine fibroids. Method: Seventy-two female adult SD rats of SPF grade were randomly divided into a model group,a normal group,and a preventive administration group. T ... Full text Cite

The Synergistic Effects of Astragalus mongholicus and Salvia miltiorrhiza on Coronary Heart Disease Identified by Network Pharmacology and Experiment.

Journal Article Drug design, development and therapy · January 2021 Background and purposeTwo Chinese herbal medicines Huang Qi (HQ, Astragalus mongholicus) and Dan Shen (DS, Salvia miltiorrhiza) are often combined to treat coronary heart disease (CHD). The purpose of this study was to identify the u ... Full text Cite

Analysis of the Efficacy and Mechanism of Action of Xuebijing Injection on ARDS Using Meta-Analysis and Network Pharmacology.

Journal Article BioMed research international · January 2021 ObjectiveAcute respiratory distress syndrome (ARDS) is defined as the acute onset of noncardiogenic edema and subsequent gas-exchange impairment due to a severe inflammatory process known as cytokine storm. Xuebijing injection (hereinafter referre ... Full text Cite

Effects of Danlou tablet for the treatment of stable angina pectoris: A study protocol of a randomized, double-blind, and placebo-controlled clinical trial.

Journal Article Medicine · December 2020 IntroductionStable angina pectoris has a high prevalence and causes serious harm. Revascularization therapy can relieve angina pectoris to some extent, but it is not widely accepted in China due to the cost and secondary events. The Chinese propri ... Full text Cite

Panax Notoginseng Saponins Inhibits Ventricular Remodeling after Myocardial Infarction in Rats Through Regulating ATF3/MAP2K3/p38 MAPK and NF κ B Pathway.

Journal Article Chinese journal of integrative medicine · December 2020 ObjectiveTo explore whether Panax notoginseng saponins (PNS) exhibits heart protective effect in myocardial infarction (MI) rats and to identify the potential signaling pathways involved.MethodsMI rats induced by ligating the left anterio ... Full text Cite

The association between gestational diabetes mellitus and cancer in women: A systematic review and meta-analysis of observational studies.

Journal Article Diabetes Metab · November 2020 AIM: Both type 1 and type 2 diabetes are associated with greater risk of a variety of cancers. However, the association between gestational diabetes mellitus (GDM) and risk of cancer has so far not been well addressed. This study aimed to summarize the epi ... Full text Link to item Cite

Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants.

Journal Article Nat Commun · October 14, 2020 Chronic obstructive pulmonary disease (COPD), diagnosed by reduced lung function, is a leading cause of morbidity and mortality. We performed whole genome sequence (WGS) analysis of lung function and COPD in a multi-ethnic sample of 11,497 participants fro ... Full text Link to item Cite

Inherited causes of clonal haematopoiesis in 97,691 whole genomes.

Journal Article Nature · October 2020 Age is the dominant risk factor for most chronic human diseases, but the mechanisms through which ageing confers this risk are largely unknown1. The age-related acquisition of somatic mutations that lead to clonal expansion in regenerating haematopoietic s ... Full text Link to item Cite

Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.

Journal Article Cell · September 3, 2020 Most loci identified by GWASs have been found in populations of European ancestry (EUR). In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including 184,535 non-EUR individuals, we identified 5,552 trait-variant association ... Full text Link to item Cite

The Polygenic and Monogenic Basis of Blood Traits and Diseases.

Journal Article Cell · September 3, 2020 Blood cells play essential roles in human health, underpinning physiological processes such as immunity, oxygen transport, and clotting, which when perturbed cause a significant global health burden. Here we integrate data from UK Biobank and a large-scale ... Full text Link to item Cite

Bayesian shrinkage estimation of high dimensional causal mediation effects in omics studies.

Journal Article Biometrics · September 2020 Causal mediation analysis aims to examine the role of a mediator or a group of mediators that lie in the pathway between an exposure and an outcome. Recent biomedical studies often involve a large number of potential mediators based on high-throughput tech ... Full text Link to item Cite

Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale.

Journal Article Nat Genet · September 2020 Large-scale whole-genome sequencing studies have enabled the analysis of rare variants (RVs) associated with complex phenotypes. Commonly used RV association tests have limited scope to leverage variant functions. We propose STAAR (variant-set test for ass ... Full text Link to item Cite

Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke.

Journal Article Stroke · August 2020 BACKGROUND AND PURPOSE: Stroke is a complex disease with multiple genetic and environmental risk factors. Blacks endure a nearly 2-fold greater risk of stroke and are 2× to 3× more likely to die from stroke than European Americans. METHODS: The COMPASS (Co ... Full text Link to item Cite

Whole Blood DNA Methylation Signatures of Diet Are Associated With Cardiovascular Disease Risk Factors and All-Cause Mortality.

Journal Article Circulation. Genomic and precision medicine · August 2020 BackgroundDNA methylation patterns associated with habitual diet have not been well studied.MethodsDiet quality was characterized using a Mediterranean-style diet score and the Alternative Healthy Eating Index score. We conducted ethnicit ... Full text Cite

Social regulation of inflammation related gene expression in the multi-ethnic study of atherosclerosis.

Journal Article Psychoneuroendocrinology · July 2020 BACKGROUND: Exposure to adverse social factors has been associated with an altered inflammatory profile, a risk factor for several acute and chronic diseases. Differential gene expression may be a biological mediator in the relationship. In this study, ass ... Full text Link to item Cite

Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry.

Journal Article Pharmacogenomics J · June 2020 Hypertension (HTN) is a significant risk factor for cardiovascular morbidity and mortality. Metabolic abnormalities, including adverse cholesterol and triglycerides (TG) profiles, are frequent comorbid findings with HTN and contribute to cardiovascular dis ... Full text Link to item Cite

Soy intake and breast cancer risk: a prospective study of 300,000 Chinese women and a dose-response meta-analysis.

Journal Article Eur J Epidemiol · June 2020 Epidemiological evidence on the association of soy intake with breast cancer risk is still inconsistent due to different soy intake levels across previous studies and small number of breast cancer cases. We aimed to investigate this issue by analyzing data ... Full text Link to item Cite

Low oxygen saturation during sleep reduces CD1D and RAB20 expressions that are reversed by CPAP therapy.

Journal Article EBioMedicine · June 2020 BACKGROUND: Sleep Disordered Breathing (SDB) is associated with a wide range of pathophysiological changes due, in part, to hypoxemia during sleep. We sought to identify gene transcription associations with measures of SDB and hypoxemia during sleep, and s ... Full text Link to item Cite

Comparison of Proteomic Assessment Methods in Multiple Cohort Studies

Journal Article Proteomics · June 1, 2020 Novel proteomics platforms, such as the aptamer-based SOMAscan platform, can quantify large numbers of proteins efficiently and cost-effectively and are rapidly growing in popularity. However, comparisons to conventional immunoassays remain underexplored, ... Full text Cite

Publisher Correction: Systemic inflammation is associated with incident stroke and heart disease in East Asians.

Journal Article Sci Rep · May 12, 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Full text Link to item Cite

Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.

Journal Article Nat Commun · April 1, 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Full text Link to item Cite

Mortality and recurrent vascular events after first incident stroke: a 9-year community-based study of 0·5 million Chinese adults.

Journal Article Lancet Glob Health · April 2020 BACKGROUND: Stroke is a leading cause of death and disability worldwide. Despite considerable improvements in diagnosis and treatment, little is known about the short-term and long-term prognosis after a first stroke in low-income and middle-income countri ... Full text Link to item Cite

Systemic inflammation is associated with incident stroke and heart disease in East Asians.

Journal Article Sci Rep · March 27, 2020 Systemic inflammation, reflected by increased plasma concentrations of C-reactive protein (CRP) and fibrinogen, is associated with increased risk of coronary heart disease, but its relevance for stroke types remains unclear. Moreover, evidence is limited i ... Full text Link to item Cite

Abstract P146: Telomere Length, DNA Methylation, and Risk of Cardiovascular Diseases: Meta-EWAS of Four Multi-ethnic Prospective Cohorts

Conference Circulation · March 3, 2020 Background: Biological aging assessed by both leukocyte telomere length (LTL) and DNA methylation (DNAm) has been associated with CVD and its risk factors. Moreover, LTL is epigenetically regulated. W ... Full text Cite

Cooking fuels and risk of all-cause and cardiopulmonary mortality in urban China: a prospective cohort study.

Journal Article Lancet Glob Health · March 2020 BACKGROUND: Cooking practice has transitioned from use of solid fuels to use of clean fuels, with addition of better ventilation facilities. However, the change in mortality risk associated with such a transition remains unclear. METHODS: The China Kadoori ... Full text Link to item Cite

Pregnancy, pregnancy loss and the risk of diabetes in Chinese women: findings from the China Kadoorie Biobank.

Journal Article Eur J Epidemiol · March 2020 Pregnancy and pregnancy loss may be associated with increased risk of diabetes in later life. However, the evidence is inconsistent and sparse, especially among East Asians where reproductive patterns differ importantly from those in the West. We examined ... Full text Link to item Cite

Cancer incidence in relation to body fatness among 0.5 million men and women: Findings from the China Kadoorie Biobank.

Journal Article Int J Cancer · February 15, 2020 High body mass index (BMI) has been associated with an increased risk of several cancers. Evidence relating body fatness, especially based on different anthropometric measures, to risk of major cancers in China from prospective cohort studies is lacking. T ... Full text Link to item Cite

Network Pharmacology-based Mechanism of Xiao Xianxiongtang in Treatment of Coronary Heart Disease

Journal Article Chinese Journal of Experimental Traditional Medical Formulae · January 1, 2020 Objective; To predict Xiao Xianxiongtang s treatment of coronary heart disease (CHD) targets and analyze their function by the network pharmacology method, and build ingredients-targets-channel network pharmacological model, in order to reveal potential pa ... Full text Cite

Uncovering the protective mechanism of Huoxue Anxin Recipe against coronary heart disease by network analysis and experimental validation.

Journal Article Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · January 2020 Coronary heart disease (CHD) is a leading cause of death and disability worldwide. Huoxue Anxin Recipe (HAR) is a novel Chinese Herbal Medicine formula of that has been used to treat CHD for several decades. Our previous study found that HAR had anti-oxida ... Full text Cite

Association of Lymphopenia With Risk of Mortality Among Adults in the US General Population.

Journal Article JAMA Netw Open · December 2, 2019 IMPORTANCE: Immune dysregulation can increase the risk of infection, malignant neoplasms, and cardiovascular disease, but improved methods are needed to identify and quantify immunologic hazard in the general population. OBJECTIVE: To determine whether lym ... Full text Link to item Cite

Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium.

Journal Article Mol Psychiatry · December 2019 Macronutrient intake, the proportion of calories consumed from carbohydrate, fat, and protein, is an important risk factor for metabolic diseases with significant familial aggregation. Previous studies have identified two genetic loci for macronutrient int ... Full text Link to item Cite

Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma.

Conference Chest · December 2019 BACKGROUND: Asthma is a common respiratory disorder with a highly heterogeneous nature that remains poorly understood. The objective was to use whole genome sequencing (WGS) data to identify regions of common genetic variation contributing to lung function ... Full text Link to item Cite

Association between sleep disordered breathing and epigenetic age acceleration: Evidence from the Multi-Ethnic Study of Atherosclerosis.

Journal Article EBioMedicine · December 2019 BACKGROUND: Sleep disordered breathing (SDB) is a common disorder that results in oxidative stress and inflammation and is associated with multiple age-related health outcomes. Epigenetic age acceleration is a DNA methylation (DNAm)-based marker of fast bi ... Full text Link to item Cite

Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration.

Journal Article Nat Commun · November 12, 2019 Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses o ... Full text Link to item Cite

Sequencing Analysis at 8p23 Identifies Multiple Rare Variants in DLC1 Associated with Sleep-Related Oxyhemoglobin Saturation Level.

Journal Article Am J Hum Genet · November 7, 2019 Average arterial oxyhemoglobin saturation during sleep (AvSpO2S) is a clinically relevant measure of physiological stress associated with sleep-disordered breathing, and this measure predicts incident cardiovascular disease and mortality. Using high-depth ... Full text Link to item Cite

Adherence to a healthy lifestyle and all-cause and cause-specific mortality in Chinese adults: a 10-year prospective study of 0.5 million people.

Journal Article Int J Behav Nutr Phys Act · November 4, 2019 BACKGROUND: Adherence to a healthy lifestyle is associated with substantially lower risks of mortality from all causes, cardiovascular diseases, and cancer in white populations. However, little is known about the health benefits among non-white populations ... Full text Link to item Cite

Molecular machinery and interplay of apoptosis and autophagy in coronary heart disease.

Journal Article Journal of molecular and cellular cardiology · November 2019 Coronary heart disease (CHD) is a common heart disease and the leading cause of cardiovascular death. Apoptosis and autophagy are two forms of programmed cell deaths which participate in the pathogenesis, development and prognosis of CHD. They are activate ... Full text Cite

Impact of Rare and Common Genetic Variants on Diabetes Diagnosis by Hemoglobin A1c in Multi-Ancestry Cohorts: The Trans-Omics for Precision Medicine Program.

Journal Article Am J Hum Genet · October 3, 2019 Hemoglobin A1c (HbA1c) is widely used to diagnose diabetes and assess glycemic control in individuals with diabetes. However, nonglycemic determinants, including genetic variation, may influence how accurately HbA1c reflects underlying glycemia. Analyzing ... Full text Link to item Cite

Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking.

Journal Article Epigenomics · October 2019 Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We sepa ... Full text Link to item Cite

Vitamin D and cause-specific vascular disease and mortality: a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults.

Journal Article BMC Med · August 30, 2019 BACKGROUND: Randomised control trials and genetic analyses have demonstrated that vitamin D or 25-hydroxyvitamin D (25[OH]D) levels may not play a causal role in the development of cardiovascular disease. However, it is unclear if 25(OH)D is causally assoc ... Full text Link to item Cite

Carotid Intima-Media Thickness but Not Carotid Artery Plaque in Healthy Individuals Is Linked to Lean Body Mass.

Journal Article J Am Heart Assoc · August 6, 2019 Background Lean body mass has been identified as a key determinant of left ventricular mass and wall thickness. However, the importance of lean body mass or other body-size measures as normative determinants of carotid intima-media thickness (cIMT), a wide ... Full text Link to item Cite

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure.

Journal Article Hum Mol Genet · August 1, 2019 Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene-smoking interactio ... Full text Link to item Cite

Epigenome-wide association analysis of daytime sleepiness in the Multi-Ethnic Study of Atherosclerosis reveals African-American-specific associations.

Journal Article Sleep · August 1, 2019 STUDY OBJECTIVES: Daytime sleepiness is a consequence of inadequate sleep, sleep-wake control disorder, or other medical conditions. Population variability in prevalence of daytime sleepiness is likely due to genetic and biological factors as well as socia ... Full text Link to item Cite

Association between tea consumption and risk of cancer: a prospective cohort study of 0.5 million Chinese adults.

Journal Article Eur J Epidemiol · August 2019 Current experimental and epidemiological studies provide inconsistent evidence toward the association between tea consumption and cancer incidence. We investigated whether tea consumption was associated with the incidence of all cancers and six leading typ ... Full text Link to item Cite

Transcriptome sequencing of lncRNA, miRNA, mRNA and interaction network constructing in coronary heart disease.

Journal Article BMC medical genomics · August 2019 BackgroundNon-coding RNA has been shown to participate in numerous biological and pathological processes and has attracted increasing attention in recent years. Recent studies have demonstrated that long non-coding RNA and micro RNA can interact t ... Full text Cite

Effectiveness and safety of Chinese herbal medicine xuanbi antong granules for the treatment of borderline coronary lesions: study protocol for a randomised, double-blinded, placebo-controlled, multicentre clinical trial.

Journal Article BMJ open · August 2019 IntroductionAs the early stage of coronary heart disease (CHD), borderline coronary lesion (BCL) is defined as a 30%-70% diameter stenosis. Previous studies have demonstrated that BCL may progress to acute coronary syndrome easily. However, routin ... Full text Cite

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Journal Article Nat Genet · July 2019 An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Full text Link to item Cite

Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Journal Article Nat Genet · July 2019 An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Full text Link to item Cite

Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals.

Journal Article J Am Coll Cardiol · June 25, 2019 BACKGROUND: Subclinical changes on the electrocardiogram are risk factors for cardiovascular mortality. Recognition and knowledge of electrolyte associations in cardiac electrophysiology are based on only in vitro models and observations in patients with s ... Full text Link to item Cite

Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.

Journal Article Am J Epidemiol · June 1, 2019 A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide asso ... Full text Link to item Cite

A Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Nonalcoholic Fatty Liver Disease.

Journal Article Diabetes · May 2019 Nonalcoholic fatty liver disease (NAFLD) is a risk factor for type 2 diabetes (T2D). We aimed to identify the peripheral blood DNA methylation signature of hepatic fat. We conducted epigenome-wide association studies of hepatic fat in 3,400 European ancest ... Full text Link to item Cite

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.

Journal Article Nat Genet · April 2019 The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking i ... Full text Link to item Cite

Causal associations of blood lipids with risk of ischemic stroke and intracerebral hemorrhage in Chinese adults.

Journal Article Nat Med · April 2019 Stroke is the second leading cause of death worldwide and accounts for >2 million deaths annually in China1,2. Ischemic stroke (IS) and intracerebral hemorrhage (ICH) account for an equal number of deaths in China, despite a fourfold greater incidence of I ... Full text Link to item Cite

Researches on Diagnostic Criteria, Biological Basis, Evidence Based Medicine for Coronary Heart Disease with Blood Stasis Syndrome

Journal Article Chinese Journal of Experimental Traditional Medical Formulae · April 1, 2019 Coronary heart disease (CHD) has become a major disease that seriously endangers human health. It belongs to the category of " chest obstruction" and " genuine heart pain" in Chinese medicine, and blood stasis syndrome is its core pathogenesis of CHD, whic ... Full text Cite

Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study.

Journal Article Neurology · February 26, 2019 OBJECTIVE: To determine whether serum magnesium and calcium concentrations are causally associated with ischemic stroke or any of its subtypes using the mendelian randomization approach. METHODS: Analyses were conducted using summary statistics data for 13 ... Full text Link to item Cite

Disentangling the genetics of lean mass.

Journal Article Am J Clin Nutr · February 1, 2019 BACKGROUND: Lean body mass (LM) plays an important role in mobility and metabolic function. We previously identified five loci associated with LM adjusted for fat mass in kilograms. Such an adjustment may reduce the power to identify genetic signals having ... Full text Link to item Cite

Solid Fuel Use and Risks of Respiratory Diseases. A Cohort Study of 280,000 Chinese Never-Smokers.

Journal Article Am J Respir Crit Care Med · February 1, 2019 RATIONALE: Little evidence from large-scale cohort studies exists about the relationship of solid fuel use with hospitalization and mortality from major respiratory diseases. OBJECTIVES: To examine the associations of solid fuel use and risks of acute and ... Full text Link to item Cite

Mechanisms of Gexia Zhuyu Decoction on anti-angiogenesis of hepatic fibrosis based on regulation of VEGF mRNA expression mediated by HIF-1α

Journal Article Chinese Traditional and Herbal Drugs · January 28, 2019 Objective To explore the mechanism of improving angiogenesis of hepatic fibrosis by Gexia Zhuyu Decoction (GZD) through the regulation of the mRNA expression of VEGF mediated by HIF-1α. Methods A total of 108 Wistar rats were randomly divided into normal g ... Full text Cite

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.

Journal Article Nat Commun · January 22, 2019 Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of ci ... Full text Link to item Cite

Expression of socially sensitive genes: The multi-ethnic study of atherosclerosis.

Journal Article PLoS One · 2019 BACKGROUND: Gene expression may be an important biological mediator in associations between social factors and health. However, previous studies were limited by small sample sizes and use of differing cell types with heterogeneous expression patterns. We u ... Full text Link to item Cite

Network pharmacology-based prediction and verification of the targets and mechanism for panax notoginseng saponins against coronary heart disease

Journal Article Evidence-based Complementary and Alternative Medicine · January 1, 2019 Coronary heart disease (CHD) is the worldwide leading cause for cardiovascular death. Panax notoginseng saponin (PNS), which is the main bioactive compound of panax notoginseng, has been generally accepted to exert a remarkable effect on CHD for a long tim ... Full text Cite

Bioactive ingredients in Chinese herbal medicines that target non-coding RNAs: Promising new choices for disease treatment

Journal Article Frontiers in Pharmacology · January 1, 2019 Chinese herbal medicines (CHMs) are widely used in China and have long been a powerful method to treat diseases in Chinese people. Bioactive ingredients are the main components extracted from herbs that have therapeutic properties. Since artemisinin was di ... Full text Cite

AST to ALT ratio and arterial stiffness in non-fatty liver Japanese population:a secondary analysis based on a cross-sectional study.

Journal Article Lipids Health Dis · December 3, 2018 BACKGROUND: Previous studies have revealed that triglyceride to high-density lipoprotein cholesterol (HDL-C) ratio (henceforth TG/HDL-C) is one of the major risk factors for cardiovascular disease, insulin resistance and metabolism syndrome. However, there ... Full text Link to item Cite

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

Journal Article Nat Genet · December 2018 In the version of this article originally published, the name of author Martin H. de Borst was coded incorrectly in the XML. The error has now been corrected in the HTML version of the paper. ... Full text Link to item Cite

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.

Journal Article Am J Hum Genet · November 1, 2018 C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The genetic determinants of chronic inflammation remain largely unknown, and the causal role of CRP in several clinical ou ... Full text Link to item Cite

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

Journal Article Nat Genet · October 2018 High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ... Full text Link to item Cite

Rare loss of function variants in candidate genes and risk of colorectal cancer.

Journal Article Hum Genet · October 2018 Although ~ 25% of colorectal cancer or polyp (CRC/P) cases show familial aggregation, current germline genetic testing identifies a causal genotype in the 16 major genes associated with high penetrance CRC/P in only 20% of these cases. As there are likely ... Full text Link to item Cite

Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.

Journal Article Nat Commun · August 23, 2018 The original version of this article contained an error in the name of the author Ramachandran S. Vasan, which was incorrectly given as Vasan S. Ramachandran. This has now been corrected in both the PDF and HTML versions of the article. ... Full text Link to item Cite

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals.

Journal Article Nat Commun · August 23, 2018 Large-scale deep-coverage whole-genome sequencing (WGS) is now feasible and offers potential advantages for locus discovery. We perform WGS in 16,324 participants from four ancestries at mean depth >29X and analyze genotypes with four quantitative traits-p ... Full text Link to item Cite

Genetic architecture of gene expression traits across diverse populations.

Journal Article PLoS Genet · August 2018 For many complex traits, gene regulation is likely to play a crucial mechanistic role. How the genetic architectures of complex traits vary between populations and subsequent effects on genetic prediction are not well understood, in part due to the histori ... Full text Link to item Cite

Efficacy and safety of oral Panax notoginseng saponins for unstable angina patients: A meta-analysis and systematic review.

Journal Article Phytomedicine : international journal of phytotherapy and phytopharmacology · August 2018 BackgroundPanax notoginseng saponins (PNS) is one of the most important active ingredients in Panax notoginseng, which plays an important role against cardiovascular diseases in Traditional Chinese Medicine (TCM).MethodsThis review was pe ... Full text Cite

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.

Journal Article Nat Commun · July 30, 2018 Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmo ... Full text Link to item Cite

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.

Journal Article Nat Commun · July 25, 2018 Electrocardiographic PR interval measures atrio-ventricular depolarization and conduction, and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genome-wide association study of over 92,000 European-descent individuals iden ... Full text Link to item Cite

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.

Journal Article Nat Commun · July 4, 2018 Lipoprotein(a), Lp(a), is a modified low-density lipoprotein particle that contains apolipoprotein(a), encoded by LPA, and is a highly heritable, causal risk factor for cardiovascular diseases that varies in concentrations across ancestries. Here, we use d ... Full text Link to item Cite

Epigenetic mechanisms in coronary artery disease: The current state and prospects.

Journal Article Trends in cardiovascular medicine · July 2018 Coronary artery disease (CAD) is the leading cause of morbidity and mortality. CAD has both genetic and environmental causes. In the past two decades, the understanding of epigenetics has advanced swiftly and vigorously. It has been demonstrated that epige ... Full text Cite

Proteomic Architecture of Human Coronary and Aortic Atherosclerosis.

Journal Article Circulation · June 19, 2018 BACKGOUND: The inability to detect premature atherosclerosis significantly hinders implementation of personalized therapy to prevent coronary heart disease. A comprehensive understanding of arterial protein networks and how they change in early atheroscler ... Full text Link to item Cite

Association between multiple comorbidities and self-rated health status in middle-aged and elderly Chinese: the China Kadoorie Biobank study.

Journal Article BMC Public Health · June 15, 2018 BACKGROUND: Understanding the correlates of self-rated health (SRH) can help public health professionals prioritize health-promotion and disease-prevention interventions. This study aimed to investigate the association between multiple comorbidities and gl ... Full text Link to item Cite

Adiposity and risk of ischaemic and haemorrhagic stroke in 0·5 million Chinese men and women: a prospective cohort study.

Journal Article Lancet Glob Health · June 2018 BACKGROUND: China has high stroke rates despite the population being relatively lean. Uncertainty persists about the relevance of adiposity to risk of stroke types. We aimed to assess the associations of adiposity with incidence of stroke types and effect ... Full text Link to item Cite

Age-specific association between blood pressure and vascular and non-vascular chronic diseases in 0·5 million adults in China: a prospective cohort study.

Journal Article Lancet Glob Health · June 2018 BACKGROUND: The age-specific association between blood pressure and vascular disease has been studied mostly in high-income countries, and before the widespread use of brain imaging for diagnosis of the main stroke types (ischaemic stroke and intracerebral ... Full text Link to item Cite

Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes.

Journal Article Am J Alzheimers Dis Other Demen · May 2018 BACKGROUND/RATIONALE: Experimental studies support the role of neurotransmitter genes in dementia risk, but human studies utilizing single variants in candidate genes have had limited success. METHODS: We used the gene-based testing program Versatile Gene- ... Full text Link to item Cite

Identification of Smoking-Associated Differentially Methylated Regions Using Reduced Representation Bisulfite Sequencing and Cell type-Specific Enhancer Activation and Gene Expression.

Journal Article Environ Health Perspect · April 27, 2018 BACKGROUND: Cigarette smoke is a causal factor in cancers and cardiovascular disease. Smoking-associated differentially methylated regions (SM-DMRs) have been observed in disease studies, but the causal link between altered DNA methylation and transcriptio ... Full text Link to item Cite

An epigenetic biomarker of aging for lifespan and healthspan.

Journal Article Aging (Albany NY) · April 18, 2018 Identifying reliable biomarkers of aging is a major goal in geroscience. While the first generation of epigenetic biomarkers of aging were developed using chronological age as a surrogate for biological age, we hypothesized that incorporation of composite ... Full text Link to item Cite

Elevations in neutrophils with obstructive sleep apnea: The Multi-Ethnic Study of Atherosclerosis (MESA).

Journal Article Int J Cardiol · April 15, 2018 BACKGROUND: Obstructive sleep apnea (OSA) associates with increased risk of cardiovascular diseases (CVD). Immune abnormalities and surges in sympathetic activity accompany OSA and CVD. We hypothesized that OSA associates with leukocytosis partially by abn ... Full text Link to item Cite

Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations.

Journal Article J Clin Endocrinol Metab · April 1, 2018 CONTEXT: Vitamin D inadequacy is common in the adult population of the United States. Although the genetic determinants underlying vitamin D inadequacy have been studied in people of European ancestry, less is known about populations with Hispanic or Afric ... Full text Link to item Cite

Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology.

Journal Article Pharmacogenomics J · April 2018 Thiazide diuretics, commonly used antihypertensives, may cause QT interval (QT) prolongation, a risk factor for highly fatal and difficult to predict ventricular arrhythmias. We examined whether common single-nucleotide polymorphisms (SNPs) modified the as ... Full text Link to item Cite

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Journal Article Nat Genet · April 2018 Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, ... Full text Link to item Cite

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.

Journal Article Nat Genet · April 2018 We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10-7); of these, 16 map outside known risk-associated loci. We make two important obse ... Full text Link to item Cite

Smoking and smoking cessation in relation to risk of diabetes in Chinese men and women: a 9-year prospective study of 0·5 million people.

Journal Article Lancet Public Health · April 2018 BACKGROUND: In developed countries, smoking is associated with increased risk of diabetes. Little is known about the association in China, where cigarette consumption has increased (first in urban, then in rural areas) relatively recently. Moreover, uncert ... Full text Link to item Cite

Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men.

Journal Article J Clin Endocrinol Metab · March 1, 2018 CONTEXT: Serum estradiol (E2) and estrone (E1) levels exhibit substantial heritability. OBJECTIVE: To investigate the genetic regulation of serum E2 and E1 in men. DESIGN, SETTING, AND PARTICIPANTS: Genome-wide association study in 11,097 men of European o ... Full text Link to item Cite

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.

Journal Article Am J Hum Genet · March 1, 2018 Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behavior may help identify BP loci and extend our knowledge of its ... Full text Link to item Cite

The role of DNA methylation in coronary artery disease.

Journal Article Gene · March 2018 Epigenetic studies have identified DNA methylation in coronary artery disease (CAD). How the critical genes interact at the cellular level to cause CAD is still unknown. The discovery of DNA methylation inspired researchers to explore relationships in geno ... Full text Cite

Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent.

Journal Article Mol Nutr Food Res · February 2018 SCOPE: Body weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption. METHODS AND RESULTS: A genome-wide interaction study to discover ... Full text Link to item Cite

A DNA methylation biomarker of alcohol consumption.

Journal Article Mol Psychiatry · February 2018 The lack of reliable measures of alcohol intake is a major obstacle to the diagnosis and treatment of alcohol-related diseases. Epigenetic modifications such as DNA methylation may provide novel biomarkers of alcohol use. To examine this possibility, we pe ... Full text Link to item Cite

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.

Journal Article Nat Commun · January 17, 2018 Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this ... Full text Link to item Cite

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.

Journal Article Am J Hum Genet · January 4, 2018 Bone mineral density (BMD) assessed by DXA is used to evaluate bone health. In children, total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar spine (LS) and femoral neck (FN) is used to diagnose osteoporosis. To date, gen ... Full text Link to item Cite

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Journal Article Nat Genet · January 2018 Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challe ... Full text Link to item Cite

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

Journal Article PLoS One · 2018 Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol con ... Full text Link to item Cite

Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group.

Journal Article Pharmacogenomics J · January 2018 Sulfonylureas, a commonly used class of medication used to treat type 2 diabetes, have been associated with an increased risk of cardiovascular disease. Their effects on QT interval duration and related electrocardiographic phenotypes are potential mechani ... Full text Link to item Cite

Patterns and management of chronic obstructive pulmonary disease in urban and rural China: A community-based survey of 25 000 adults across 10 regions

Journal Article BMJ Open Respiratory Research · January 1, 2018 Introduction Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, with COPD deaths in China accounting for one-third of all such deaths. However, there is limited available evidence on the management of COPD in China. ... Full text Cite

Meta-analysis of exome array data identifies six novel genetic loci for lung function

Journal Article Wellcome Open Research · January 1, 2018 Background: Over 90 regions of the genome have been associated with lung function to date, many of which have also been implicated in chronic obstructive pulmonary disease. Methods: We carried out meta-analyses of exome array data and three lung function m ... Full text Cite

DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation.

Journal Article Am J Hum Genet · December 7, 2017 Genome-wide association studies have identified hundreds of genetic variants associated with blood pressure (BP), but sequence variation accounts for a small fraction of the phenotypic variance. Epigenetic changes may alter the expression of genes involved ... Full text Link to item Cite

Differentially conserved transcriptomic response to adversity related to self-rated health in the multi-ethnic study of atherosclerosis.

Journal Article Exp Biol Med (Maywood) · December 2017 Self-rated health (SRH) is considered a strong indicator of well-being and clinical health status and has been linked to inflammatory markers. The objective of this work was to examine how self-rated physical health (SRPH) and mental health (SRMH) influenc ... Full text Link to item Cite

Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans.

Journal Article Mol Neurobiol · December 2017 The human sense of smell decreases with age, and a poor sense of smell are among the most important prodromal symptoms of several neurodegenerative diseases. Recent evidence further suggests a racial difference in the sense of smell among U.S. older adults ... Full text Link to item Cite

Association of Physical Activity With Risk of Major Cardiovascular Diseases in Chinese Men and Women.

Journal Article JAMA Cardiol · December 1, 2017 IMPORTANCE: In China, the patterns and levels of physical activity differed from those in high-income countries. Substantial uncertainty remains about the relevance, both qualitatively and quantitatively, of domain-specific physical activity for cardiovasc ... Full text Link to item Cite

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Journal Article Nat Commun · November 7, 2017 A correction to this article has been published and is linked from the HTML version of this article. ... Full text Open Access Link to item Cite

D-Dimer in African Americans: Whole Genome Sequence Analysis and Relationship to Cardiovascular Disease Risk in the Jackson Heart Study.

Journal Article Arterioscler Thromb Vasc Biol · November 2017 OBJECTIVE: Plasma levels of the fibrinogen degradation product D-dimer are higher among African Americans (AAs) compared with those of European ancestry and higher among women compared with men. Among AAs, little is known of the genetic architecture of D-d ... Full text Link to item Cite

Panax notoginseng saponins for treating coronary artery disease: A functional and mechanistic overview

Journal Article Frontiers in Pharmacology · October 17, 2017 Coronary artery disease (CAD) is a major public health problem and the chief cause of morbidity and mortality worldwide. Panax notoginseng, a valuable herb in traditional Chinese medicine (TCM) with obvious efficacy and favorable safety, shows a great prom ... Full text Cite

Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure.

Journal Article Hypertension · October 2017 Hypertension represents a major cardiovascular risk factor. The pathophysiology of increased blood pressure (BP) is not yet completely understood. Transcriptome profiling offers possibilities to uncover genetics effects on BP. Based on 2 populations includ ... Full text Link to item Cite

Genomewide Association Scan of a Mortality Associated Endophenotype for a Long and Healthy Life in the Long Life Family Study.

Journal Article J Gerontol A Biol Sci Med Sci · October 1, 2017 BACKGROUND: Identification of genes or fundamental biological pathways that regulate aging phenotypes and longevity could lead to possible interventions to increase healthy longevity. METHODS: Using data from the Long Life Family Study, we performed genome ... Full text Link to item Cite

Fresh fruit consumption and all-cause and cause-specific mortality: findings from the China Kadoorie Biobank.

Journal Article Int J Epidemiol · October 1, 2017 BACKGROUND: Higher fruit consumption is associated with lower risk of cardiovascular disease (CVD). Substantial uncertainties remain, however, about the associations of fruit consumption with all-cause mortality and mortality from subtypes of CVD and major ... Full text Link to item Cite

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.

Journal Article PLoS Med · September 2017 BACKGROUND: Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and assess glycemic control in patients with diabetes. Previous genome-wide association studies (GWAS) have identified 18 HbA1c-associated genetic variants. These variants pr ... Full text Link to item Cite

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.

Journal Article Hypertension · September 2017 Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. ... Full text Link to item Cite

Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis.

Journal Article Nat Commun · August 30, 2017 Little is known regarding the epigenetic basis of atherosclerosis. Here we present the CD14+ blood monocyte transcriptome and epigenome signatures associated with human atherosclerosis. The transcriptome signature includes transcription coactivator, ARID5B ... Full text Link to item Cite

Pregnancy, pregnancy loss, and the risk of cardiovascular disease in Chinese women: findings from the China Kadoorie Biobank.

Journal Article BMC Med · August 8, 2017 BACKGROUND: Pregnancy and pregnancy loss may be linked to cardiovascular disease (CVD). However, the evidence is still inconsistent, especially in East Asians, whose reproductive patterns differ importantly from those in the West. We examined the associati ... Full text Link to item Cite

Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

Journal Article PLoS Genet · August 2017 [This corrects the article DOI: 10.1371/journal.pgen.1006528.]. ... Full text Link to item Cite

PCSK9 Loss-of-Function Variants, Low-Density Lipoprotein Cholesterol, and Risk of Coronary Heart Disease and Stroke: Data From 9 Studies of Blacks and Whites.

Journal Article Circ Cardiovasc Genet · August 2017 BACKGROUND: PCSK9 loss-of-function (LOF) variants allow for the examination of the effects of lifetime reduced low-density lipoprotein cholesterol (LDL-C) on cardiovascular events. We examined the association of PCSK9 LOF variants with LDL-C and incident c ... Full text Link to item Cite

Neighborhood characteristics influence DNA methylation of genes involved in stress response and inflammation: The Multi-Ethnic Study of Atherosclerosis.

Journal Article Epigenetics · August 2017 Living in a disadvantaged neighborhood is associated with poor health outcomes even after accounting for individual-level socioeconomic factors. The chronic stress of unfavorable neighborhood conditions may lead to dysregulation of the stress reactivity an ... Full text Link to item Cite

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness.

Journal Article Nat Commun · July 12, 2017 Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic dis ... Full text Link to item Cite

Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.

Journal Article Cell · June 29, 2017 Type 2 diabetes (T2D) affects Latinos at twice the rate seen in populations of European descent. We recently identified a risk haplotype spanning SLC16A11 that explains ∼20% of the increased T2D prevalence in Mexico. Here, through genetic fine-mapping, we ... Full text Link to item Cite

Detection of genetic loci associated with plasma fetuin-A: a meta-analysis of genome-wide association studies from the CHARGE Consortium.

Journal Article Hum Mol Genet · June 1, 2017 Plasma fetuin-A is associated with type 2 diabetes, and AHSG, the gene encoding fetuin-A, has been identified as a susceptibility locus for diabetes and metabolic syndrome. Thus far, unbiased investigations of the genetic determinants of plasma fetuin-A co ... Full text Link to item Cite

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.

Journal Article Nat Genet · June 2017 The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes Project-imputed genotype data in up to ∼370,000 women, we identify 389 independent signals (P < 5 × 10-8) for a ... Full text Link to item Cite

Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease.

Journal Article J Am Heart Assoc · May 26, 2017 BACKGROUND: Plasminogen activator inhibitor type 1 (PAI-1) plays an essential role in the fibrinolysis system and thrombosis. Population studies have reported that blood PAI-1 levels are associated with increased risk of coronary heart disease (CHD). Howev ... Full text Link to item Cite

Corrigendum: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.

Journal Article Sci Rep · May 26, 2017 This corrects the article DOI: 10.1038/srep45040. ... Full text Link to item Cite

Longevity-Associated FOXO3 Genotype and its Impact on Coronary Artery Disease Mortality in Japanese, Whites, and Blacks: A Prospective Study of Three American Populations.

Journal Article J Gerontol A Biol Sci Med Sci · May 1, 2017 BACKGROUND: We recently reported that protection against coronary artery disease (CAD) mortality is the major contributor to longer life associated with FOXO3 genotype. The present study examined this relation in more detail. METHODS: We performed a 15-yea ... Full text Link to item Cite

A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.

Journal Article J Med Genet · May 2017 BACKGROUND: Increased heart rate and a prolonged QT interval are important risk factors for cardiovascular morbidity and mortality, and can be influenced by the use of various medications, including tricyclic/tetracyclic antidepressants (TCAs). We aim to i ... Full text Link to item Cite

1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.

Journal Article Sci Rep · April 28, 2017 HapMap imputed genome-wide association studies (GWAS) have revealed >50 loci at which common variants with minor allele frequency >5% are associated with kidney function. GWAS using more complete reference sets for imputation, such as those from The 1000 G ... Full text Link to item Cite

Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos.

Journal Article PLoS Genet · April 2017 Prior GWAS have identified loci associated with red blood cell (RBC) traits in populations of European, African, and Asian ancestry. These studies have not included individuals with an Amerindian ancestral background, such as Hispanics/Latinos, nor evaluat ... Full text Link to item Cite

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

Journal Article PLoS Genet · April 2017 Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference a ... Full text Link to item Cite

Adiposity in relation to age at menarche and other reproductive factors among 300 000 Chinese women: findings from China Kadoorie Biobank study.

Journal Article Int J Epidemiol · April 1, 2017 BACKGROUND: Adiposity is increasing rapidly in China but little is known about the relevance to it of women's reproductive factors, which differ inter-generationally and from that in the West. We assess associations of adiposity with life-course reproducti ... Full text Link to item Cite

Fresh fruit consumption in relation to incident diabetes and diabetic vascular complications: A 7-y prospective study of 0.5 million Chinese adults.

Journal Article PLoS Med · April 2017 BACKGROUND: Despite the well-recognised health benefits of fresh fruit consumption, substantial uncertainties remain about its potential effects on incident diabetes and, among those with diabetes, on risks of death and major vascular complications. METHOD ... Full text Link to item Cite

Patterns and correlates of major depression in Chinese adults: a cross-sectional study of 0.5 million men and women.

Journal Article Psychol Med · April 2017 BACKGROUND: Worldwide 350 million people suffer from major depression, with the majority of cases occurring in low- and middle-income countries. We examined the patterns, correlates and care-seeking behaviour of adults suffering from major depressive episo ... Full text Link to item Cite

Secondhand Tobacco Smoke Exposure Associations With DNA Methylation of the Aryl Hydrocarbon Receptor Repressor.

Journal Article Nicotine Tob Res · April 1, 2017 INTRODUCTION: Cigarette smoking is inversely associated with DNA methylation of the aryl hydrocarbon receptor repressor (AHRR; cg05575921). However, the association between secondhand tobacco smoke (SHS) exposure and AHRR methylation is unknown. METHODS: D ... Full text Link to item Cite

Genome-wide association of white blood cell counts in Hispanic/Latino Americans: the Hispanic Community Health Study/Study of Latinos.

Journal Article Hum Mol Genet · March 15, 2017 Circulating white blood cell (WBC) counts (neutrophils, monocytes, lymphocytes, eosinophils, basophils) differ by ethnicity. The genetic factors underlying basal WBC traits in Hispanics/Latinos are unknown. We performed a genome-wide association study of t ... Full text Link to item Cite

Adherence to Healthy Lifestyle and Cardiovascular Diseases in the Chinese Population.

Journal Article J Am Coll Cardiol · March 7, 2017 BACKGROUND: Adherence to a combination of healthy lifestyle factors has been related to a considerable reduction of cardiovascular risk in white populations; however, little is known whether such associations persist in nonwhite populations like the Asian ... Full text Link to item Cite

SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function.

Journal Article J Am Soc Nephrol · March 2017 Genome-wide association studies have identified >50 common variants associated with kidney function, but these variants do not fully explain the variation in eGFR. We performed a two-stage meta-analysis of associations between genotypes from the Illumina e ... Full text Link to item Cite

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.

Journal Article Nat Genet · March 2017 Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent rep ... Full text Link to item Cite

Rare and low-frequency coding variants alter human adult height.

Journal Article Nature · February 9, 2017 Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in ... Full text Link to item Cite

Parenthood and the risk of cardiovascular diseases among 0.5 million men and women: findings from the China Kadoorie Biobank.

Journal Article Int J Epidemiol · February 1, 2017 BACKGROUND: Women's parity has been associated with risk of cardiovascular disease (CVD). It is unclear, however, whether it reflects biological effects of childbearing or uncontrolled socio-economic and lifestyle factors associated with childrearing. We a ... Full text Link to item Cite

Molecular Profiling of Human Induced Pluripotent Stem Cell-Derived Hypothalamic Neurones Provides Developmental Insights into Genetic Loci for Body Weight Regulation.

Journal Article J Neuroendocrinol · February 2017 Recent data suggest that common genetic risks for metabolic disorders such as obesity may be human-specific and exert effects via the central nervous system. To overcome the limitation of human tissue access for study, we have generated induced human pluri ... Full text Link to item Cite

Traditional Chinese medicine suppresses left ventricular hypertrophy by targeting extracellular signal-regulated kinases signaling pathway in spontaneously hypertensive rats.

Journal Article Scientific reports · February 2017 Chinese herbal medicine Bu-Shen-Jiang-Ya decoction (BSJYD) is reported to be beneficial for hypertension. Over expression of extracellular signal regulated kinases (ERK) pathway plays an important role in left ventricular hypertrophy (LVH). This study aime ... Full text Cite

Association Between Diabetes and Cause-Specific Mortality in Rural and Urban Areas of China.

Journal Article JAMA · January 17, 2017 IMPORTANCE: In China, diabetes prevalence has increased substantially in recent decades, but there are no reliable estimates of the excess mortality currently associated with diabetes. OBJECTIVES: To assess the proportional excess mortality associated with ... Full text Link to item Cite

The complex genetics of gait speed: genome-wide meta-analysis approach.

Journal Article Aging (Albany NY) · January 10, 2017 Emerging evidence suggests that the basis for variation in late-life mobility is attributable, in part, to genetic factors, which may become increasingly important with age. Our objective was to systematically assess the contribution of genetic variation t ... Full text Link to item Cite

Tobacco exposure-related alterations in DNA methylation and gene expression in human monocytes: the Multi-Ethnic Study of Atherosclerosis (MESA).

Journal Article Epigenetics · 2017 Alterations in DNA methylation and gene expression in blood leukocytes are potential biomarkers of harm and mediators of the deleterious effects of tobacco exposure. However, methodological issues, including the use of self-reported smoking status and mixe ... Full text Link to item Cite

Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts.

Journal Article PLoS One · 2017 BACKGROUND: Regular fish and omega-3 consumption may have several health benefits and are recommended by major dietary guidelines. Yet, their intakes remain remarkably variable both within and across populations, which could partly owe to genetic influence ... Full text Link to item Cite

A novel TCF7L2 type 2 diabetes SNP identified from fine mapping in African American women.

Journal Article PLoS One · 2017 SNP rs7903146 in the Wnt pathway's TCF7L2 gene is the variant most significantly associated with type 2 diabetes to date, with associations observed across diverse populations. We sought to determine whether variants in other Wnt pathway genes are also ass ... Full text Link to item Cite

Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation.

Journal Article Nat Genet · January 2017 Variation in body fat distribution contributes to the metabolic sequelae of obesity. The genetic determinants of body fat distribution are poorly understood. The goal of this study was to gain new insights into the underlying genetics of body fat distribut ... Full text Link to item Cite

Yisui shengxue granule, a traditional Chinese medicine compound preparation, can up-regulate the expression of GM-CSF and its receptor in mice bone marrow after irradiation

Journal Article Biomedical Research (India) · January 1, 2017 Introduction: To explore the molecular mechanism of YSSXG regulates myeloid hematopoietic cell proliferation and differentiation. Materials and methods: Male Kun-Ming mice (n=52) were randomized into four groups (n=13): blank, model, positive drug, YSSXG. ... Cite

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.

Journal Article Proc Natl Acad Sci U S A · December 13, 2016 Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a genome-wide association metaanalysis a ... Full text Link to item Cite

Meta-analysis of genome-wide association studies of HDL cholesterol response to statins.

Journal Article J Med Genet · December 2016 BACKGROUND: In addition to lowering low density lipoprotein cholesterol (LDL-C), statin therapy also raises high density lipoprotein cholesterol (HDL-C) levels. Inter-individual variation in HDL-C response to statins may be partially explained by genetic v ... Full text Link to item Cite

Variants in angiopoietin-2 (ANGPT2) contribute to variation in nocturnal oxyhaemoglobin saturation level.

Journal Article Hum Mol Genet · December 1, 2016 Genetic determinants of sleep-disordered breathing (SDB), a common set of disorders that contribute to significant cardiovascular and neuropsychiatric morbidity, are not clear. Overnight nocturnal oxygen saturation (SaO2) is a clinically relevant and easil ... Full text Link to item Cite

Long-term outdoor air pollution and DNA methylation in circulating monocytes: results from the Multi-Ethnic Study of Atherosclerosis (MESA).

Journal Article Environ Health · December 1, 2016 BACKGROUND: DNA methylation may mediate effects of air pollution on cardiovascular disease. The association between long-term air pollution exposure and DNA methylation in monocytes, which are central to atherosclerosis, has not been studied. We investigat ... Full text Link to item Cite

Genome-wide analysis identifies 12 loci influencing human reproductive behavior.

Journal Article Nat Genet · December 2016 The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic ... Full text Link to item Cite

Modern researches on Blood Stasis syndrome 1989-2015: A bibliometric analysis.

Journal Article Medicine · December 2016 BackgroundBlood Stasis syndrome (BSS) is one of the major syndromes in Traditional East Asia medicine (TEAM). Modern research of BSS began in the late1980s.MethodsWe searched in PubMed for BSS-related articles published between 1989 and 2 ... Full text Cite

Erratum to: Identification of more objective biomarkers for Blood-Stasis syndrome diagnosis [BMC Complement Alternat Med., 16 (2016) (371)]

Journal Article BMC Complementary and Alternative Medicine · November 10, 2016 Following publication of the original article [1] it was brought to our attention that the sequence of the author affiliations was incorrectly ordered. In the original article the sequence appears as follows: 1Guang'anmen Hospital, China Academy of Chinese ... Full text Cite

Gene-gene Interaction Analyses for Atrial Fibrillation.

Journal Article Sci Rep · November 8, 2016 Atrial fibrillation (AF) is a heritable disease that affects more than thirty million individuals worldwide. Extensive efforts have been devoted to the study of genetic determinants of AF. The objective of our study is to examine the effect of gene-gene in ... Full text Link to item Cite

The most cited articles in coronary heart disease: A bibliometric analysis between 1970 and 2015.

Journal Article International journal of cardiology · November 2016 BackgroundResearch on coronary heart disease (CHD) remains one of the major concerns in the medical and health fields in recent decades, yet data on the circumstances of CHD are unsatisfying. We aimed to evaluate the situations and trends of the m ... Full text Cite

Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci.

Journal Article Nat Genet · October 2016 Meta-analyses of association results for blood pressure using exome-centric single-variant and gene-based tests identified 31 new loci in a discovery stage among 146,562 individuals, with follow-up and meta-analysis in 180,726 additional individuals (total ... Full text Link to item Cite

Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans.

Journal Article Hum Mol Genet · October 1, 2016 The electrocardiographic QRS duration, a measure of ventricular depolarization and conduction, is associated with cardiovascular mortality. While single nucleotide polymorphisms (SNPs) associated with QRS duration have been identified at 22 loci in populat ... Full text Link to item Cite

Epigenetic Signatures of Cigarette Smoking.

Journal Article Circ Cardiovasc Genet · October 2016 BACKGROUND: DNA methylation leaves a long-term signature of smoking exposure and is one potential mechanism by which tobacco exposure predisposes to adverse health outcomes, such as cancers, osteoporosis, lung, and cardiovascular disorders. METHODS AND RES ... Full text Link to item Cite

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits.

Journal Article Aging Cell · October 2016 The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in risk of human diseases including ca ... Full text Link to item Cite

GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium.

Journal Article Aging Cell · October 2016 Decline in muscle strength with aging is an important predictor of health trajectory in the elderly. Several factors, including genetics, are proposed contributors to variability in muscle strength. To identify genetic contributors to muscle strength, a me ... Full text Link to item Cite

The dynamic changes of DNA methylation in primordial germ cell differentiation.

Journal Article Gene · October 2016 The discovery of DNA methylation has provided a new perspective on how DNA may be dynamically regulated in the mammalian genome. DNA methylation is a dynamic process with a demethylation and de novo methylation from primordial germ cell to differentiation. ... Full text Cite

Identification of more objective biomarkers for Blood-Stasis syndrome diagnosis.

Journal Article BMC complementary and alternative medicine · September 2016 BackgroundBlood-stasis syndrome (BSS) is one of the Traditional Chinese medicine (TCM) syndrome differentiations that are commonly seen in stroke and ischemic heart diseases; however, the BSS differentiation criterion is not standardized. More obj ... Full text Cite

Huoxue Anxin Recipe () promotes myocardium angiogenesis of acute myocardial infarction rats by up-regulating miR-210 and vascular endothelial growth factor.

Journal Article Chinese journal of integrative medicine · September 2016 ObjectiveTo investigate the microRNAs (miRNAs) expression profile of acute myocardial infarction (AMI) rats and the regulating effects of Huoxue Anxin Recipe (, HAR) on angiogenesis-related miRNAs and genes.MethodsForty-five Wistar rats w ... Full text Cite

Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits.

Journal Article Nat Genet · August 2016 Hematologic measures such as hematocrit and white blood cell (WBC) count are heritable and clinically relevant. We analyzed erythrocyte and WBC phenotypes in 52,531 individuals (37,775 of European ancestry, 11,589 African Americans, and 3,167 Hispanic Amer ... Full text Link to item Cite

The FoxO3 gene and cause-specific mortality.

Journal Article Aging Cell · August 2016 The G allele of the FOXO3 single nucleotide polymorphism (SNP) rs2802292 exhibits a consistently replicated genetic association with longevity in multiple populations worldwide. The aims of this study were to quantify the mortality risk for the longevity-a ... Full text Link to item Cite

Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin.

Journal Article Am J Hum Genet · July 7, 2016 Knowledge of the genetic basis of the type 2 diabetes (T2D)-related quantitative traits fasting glucose (FG) and insulin (FI) in African ancestry (AA) individuals has been limited. In non-diabetic subjects of AA (n = 20,209) and European ancestry (EA; n = ... Full text Link to item Cite

Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals.

Journal Article Am J Hum Genet · July 7, 2016 Platelet production, maintenance, and clearance are tightly controlled processes indicative of platelets' important roles in hemostasis and thrombosis. Platelets are common targets for primary and secondary prevention of several conditions. They are monito ... Full text Link to item Cite

Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases.

Journal Article Am J Hum Genet · July 7, 2016 White blood cells play diverse roles in innate and adaptive immunity. Genetic association analyses of phenotypic variation in circulating white blood cell (WBC) counts from large samples of otherwise healthy individuals can provide insights into genes and ... Full text Link to item Cite

Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits.

Journal Article Am J Hum Genet · July 7, 2016 Red blood cell (RBC) traits are important heritable clinical biomarkers and modifiers of disease severity. To identify coding genetic variants associated with these traits, we conducted meta-analyses of seven RBC phenotypes in 130,273 multi-ethnic individu ... Full text Link to item Cite

Genetic Investigation Into the Differential Risk of Atrial Fibrillation Among Black and White Individuals.

Journal Article JAMA Cardiol · July 1, 2016 IMPORTANCE: White persons have a higher risk of atrial fibrillation (AF) compared with black individuals despite a lower prevalence of risk factors. This difference may be due, at least in part, to genetic factors. OBJECTIVES: To determine whether 9 single ... Full text Link to item Cite

An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group.

Journal Article Genet Epidemiol · July 2016 Studying gene-environment (G × E) interactions is important, as they extend our knowledge of the genetic architecture of complex traits and may help to identify novel variants not detected via analysis of main effects alone. The main statistical framework ... Full text Link to item Cite

Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies.

Journal Article Lancet Neurol · June 2016 BACKGROUND: Genetic determinants of stroke, the leading neurological cause of death and disability, are poorly understood and have seldom been explored in the general population. Our aim was to identify additional loci for stroke by doing a meta-analysis o ... Full text Link to item Cite

Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies.

Journal Article Psychol Med · June 2016 BACKGROUND: Major depressive disorder (MDD) is moderately heritable, however genome-wide association studies (GWAS) for MDD, as well as for related continuous outcomes, have not shown consistent results. Attempts to elucidate the genetic basis of MDD may b ... Full text Link to item Cite

Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure.

Journal Article PLoS Genet · May 2016 Failure of the human heart to maintain sufficient output of blood for the demands of the body, heart failure, is a common condition with high mortality even with modern therapeutic alternatives. To identify molecular determinants of mortality in patients w ... Full text Link to item Cite

The Burden of Hypertension and Associated Risk for Cardiovascular Mortality in China.

Journal Article JAMA Intern Med · April 2016 IMPORTANCE: Hypertension is a leading cause of premature death in China, but limited evidence is available on the prevalence and management of hypertension and its effect on mortality from cardiovascular disease (CVD). OBJECTIVES: To examine the prevalence ... Full text Link to item Cite

LncRNA MIAT: Myocardial infarction associated and more.

Journal Article Gene · March 2016 Non-coding RNAs are emerging as regulatory RNAs that participate in the regulation of gene expression and play vital roles in various biological and pathological processes. Long non-coding (lncRNA) is a novel class of non-coding RNAs that regulates gene ex ... Full text Cite

Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans.

Journal Article Am J Hum Genet · February 4, 2016 Platelets play an essential role in hemostasis and thrombosis. We performed a genome-wide association study of platelet count in 12,491 participants of the Hispanic Community Health Study/Study of Latinos by using a mixed-model method that accounts for adm ... Full text Link to item Cite

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.

Journal Article Nat Commun · February 1, 2016 Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe obesity, no common loci regulating circ ... Full text Link to item Cite

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

Journal Article Nat Commun · February 1, 2016 To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide s ... Full text Link to item Cite

Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium.

Journal Article Am J Clin Nutr · February 2016 BACKGROUND: DNA methylation is influenced by diet and single nucleotide polymorphisms (SNPs), and methylation modulates gene expression. OBJECTIVE: We aimed to explore whether the gene-by-diet interactions on blood lipids act through DNA methylation. DESIG ... Full text Link to item Cite

Differential gene expression analysis and network construction of recurrent cardiovascular events.

Journal Article Molecular medicine reports · February 2016 Recurrent cardiovascular events are vital to the prevention and treatment strategies in patients who have experienced primary cardiovascular events. However, the susceptibility of recurrent cardiovascular events varies among patients. Personalized treatmen ... Full text Cite

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.

Journal Article Nat Commun · January 21, 2016 Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data ... Full text Link to item Cite

Association of Forced Vital Capacity with the Developmental Gene NCOR2.

Journal Article PLoS One · 2016 BACKGROUND: Forced Vital Capacity (FVC) is an important predictor of all-cause mortality in the absence of chronic respiratory conditions. Epidemiological evidence highlights the role of early life factors on adult FVC, pointing to environmental exposures ... Full text Link to item Cite

Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium.

Journal Article PLoS One · 2016 BACKGROUND: Data are limited on genome-wide association studies (GWAS) for incident coronary heart disease (CHD). Moreover, it is not known whether genetic variants identified to date also associate with risk of CHD in a prospective setting. METHODS: We pe ... Full text Link to item Cite

Bioinformatics investigation of therapeutic mechanisms of xuesaitong capsule treating ischemic cerebrovascular rat model with comparative transcriptome analysis

Journal Article American Journal of Translational Research · January 1, 2016 Background: Xuesaitong soft capsule (XST) which consists of panax notoginseng saponin (PNS) has been used to treat ischemic cerebrovascular diseases in China. The therapeutic mechanism of XST has not been elucidated yet from prospective of genomics and bio ... Cite

Association of Aging-Related Endophenotypes With Mortality in 2 Cohort Studies: the Long Life Family Study and the Health, Aging and Body Composition Study.

Journal Article Am J Epidemiol · December 1, 2015 One method by which to identify fundamental biological processes that may contribute to age-related disease and disability, instead of disease-specific processes, is to construct endophenotypes comprising linear combinations of physiological measures. Appl ... Full text Link to item Cite

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.

Journal Article Nat Genet · November 2015 Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ∼70,000 women to identify common and low-frequency protein-coding varia ... Full text Link to item Cite

Genome-wide Meta-analysis on the Sense of Smell Among US Older Adults.

Journal Article Medicine (Baltimore) · November 2015 Olfactory dysfunction is common among older adults and affects their safety, nutrition, quality of life, and mortality. More importantly, the decreased sense of smell is an early symptom of neurodegenerative diseases such as Parkinson disease (PD) and Alzh ... Full text Link to item Cite

Mitochondrial DNA Sequence Variation Associated With Peripheral Nerve Function in the Elderly.

Journal Article J Gerontol A Biol Sci Med Sci · November 2015 BACKGROUND: Mitochondrial dysfunction is a prominent hallmark of many sensory neuropathies. The purpose of this study was to assess the influence of mitochondrial DNA sequence variation on peripheral nerve function in the population-based Health, Aging, an ... Full text Link to item Cite

Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians.

Journal Article Am J Clin Nutr · November 2015 BACKGROUND: Recent studies suggest that meat intake is associated with diabetes-related phenotypes. However, whether the associations of meat intake and glucose and insulin homeostasis are modified by genes related to glucose and insulin is unknown. OBJECT ... Full text Link to item Cite

The transcriptional landscape of age in human peripheral blood.

Journal Article Nat Commun · October 22, 2015 Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European an ... Full text Link to item Cite

Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease.

Journal Article Diabetes · October 2015 Obesity is linked to type 2 diabetes (T2D) and cardiovascular diseases; however, the underlying molecular mechanisms remain unclear. We aimed to identify obesity-associated molecular features that may contribute to obesity-related diseases. Using circulati ... Full text Link to item Cite

Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study.

Journal Article Mol Psychiatry · October 2015 Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide association study (GWAS) of usual sleep durati ... Full text Link to item Cite

Plasma Levels of Soluble Interleukin-2 Receptor α: Associations With Clinical Cardiovascular Events and Genome-Wide Association Scan.

Journal Article Arterioscler Thromb Vasc Biol · October 2015 OBJECTIVE: Interleukin (IL) -2 receptor subunit α regulates lymphocyte activation, which plays an important role in atherosclerosis. Associations between soluble IL-2Rα (sIL-2Rα) and cardiovascular disease (CVD) have not been widely studied and little is k ... Full text Link to item Cite

DNA Methylation of the Aryl Hydrocarbon Receptor Repressor Associations With Cigarette Smoking and Subclinical Atherosclerosis.

Journal Article Circ Cardiovasc Genet · October 2015 BACKGROUND: Tobacco smoke contains numerous agonists of the aryl hydrocarbon receptor (AhR) pathway, and activation of the AhR pathway was shown to promote atherosclerosis in mice. Intriguingly, cigarette smoking is most strongly and robustly associated wi ... Full text Link to item Cite

Gallstone Disease and the Risk of Ischemic Heart Disease.

Journal Article Arterioscler Thromb Vasc Biol · October 2015 OBJECTIVE: Gallstone disease (GSD) is related to multiple cardiovascular risk factors; the present study was to prospectively examine the association between GSD and ischemic heart disease (IHD). APPROACH AND RESULTS: We examined the association of GSD wit ... Full text Link to item Cite

Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry.

Journal Article Hum Mol Genet · August 15, 2015 Obesity is highly heritable. Genetic variants showing robust associations with obesity traits have been identified through genome-wide association studies. We investigated whether a composite score representing healthy diet modifies associations of these v ... Full text Link to item Cite

Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans.

Journal Article Stroke · August 2015 BACKGROUND AND PURPOSE: The majority of genome-wide association studies (GWAS) of stroke have focused on European-ancestry populations; however, none has been conducted in African Americans, despite the disproportionately high burden of stroke in this popu ... Full text Link to item Cite

The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25,000 subjects.

Journal Article Mol Psychiatry · June 2015 An association between lower educational attainment (EA) and an increased risk for depression has been confirmed in various western countries. This study examines whether pleiotropic genetic effects contribute to this association. Therefore, data were anal ... Full text Link to item Cite

Genome-wide association study of kidney function decline in individuals of European descent.

Journal Article Kidney Int · May 2015 Genome-wide association studies (GWASs) have identified multiple loci associated with cross-sectional eGFR, but a systematic genetic analysis of kidney function decline over time is missing. Here we conducted a GWAS meta-analysis among 63,558 participants ... Full text Link to item Cite

Transcriptomic profiles of aging in purified human immune cells.

Journal Article BMC Genomics · April 22, 2015 BACKGROUND: Transcriptomic studies hold great potential towards understanding the human aging process. Previous transcriptomic studies have identified many genes with age-associated expression levels; however, small samples sizes and mixed cell types often ... Full text Link to item Cite

Genetic and environmental factors are associated with serum 25-hydroxyvitamin D concentrations in older African Americans.

Journal Article J Nutr · April 2015 BACKGROUND: Low circulating 25-hydroxyvitamin D [25(OH)D] is prevalent in African Americans, but predictors of vitamin D status are understudied compared to Caucasian populations. OBJECTIVE: We investigated whether certain environmental and genetic factors ... Full text Link to item Cite

Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults.

Journal Article Obes Rev · April 2015 Previously, a single nucleotide polymorphism (SNP), rs9939609, in the FTO gene showed a much stronger association with all-cause mortality than expected from its association with body mass index (BMI), body fat mass index (FMI) and waist circumference (WC) ... Full text Link to item Cite

A meta-analysis of gene expression signatures of blood pressure and hypertension.

Journal Article PLoS Genet · March 2015 Genome-wide association studies (GWAS) have uncovered numerous genetic variants (SNPs) that are associated with blood pressure (BP). Genetic variants may lead to BP changes by acting on intermediate molecular phenotypes such as coded protein sequence or ge ... Full text Link to item Cite

Genetic studies of body mass index yield new insights for obesity biology.

Journal Article Nature · February 12, 2015 Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and a ... Full text Link to item Cite

New genetic loci link adipose and insulin biology to body fat distribution.

Journal Article Nature · February 12, 2015 Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabo ... Full text Link to item Cite

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.

Journal Article Nature · February 5, 2015 Myocardial infarction (MI), a leading cause of death around the world, displays a complex pattern of inheritance. When MI occurs early in life, genetic inheritance is a major component to risk. Previously, rare mutations in low-density lipoprotein (LDL) ge ... Full text Link to item Cite

Declines in inflammation predict greater white matter microstructure in older adults.

Journal Article Neurobiol Aging · February 2015 Protracted systemic inflammation has been associated with adverse effects on cognition and brain structure and may accelerate neurodegenerative disease processes; however, it is less clear whether changes in inflammation are associated with brain structure ... Full text Link to item Cite

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.

Journal Article Nat Commun · January 29, 2015 Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals and in 16,491 T2D cases and 81,877 c ... Full text Link to item Cite

Meta-analysis of correlated traits via summary statistics from GWASs with an application in hypertension.

Journal Article Am J Hum Genet · January 8, 2015 Genome-wide association studies (GWASs) have identified many genetic variants underlying complex traits. Many detected genetic loci harbor variants that associate with multiple-even distinct-traits. Most current analysis approaches focus on single traits, ... Full text Link to item Cite

Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci.

Journal Article PLoS One · 2015 Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, but the nature of the suggestive ... Full text Link to item Cite

Life course socioeconomic status and DNA methylation in genes related to stress reactivity and inflammation: The multi-ethnic study of atherosclerosis.

Journal Article Epigenetics · 2015 Epigenetic changes, such as DNA methylation, have been hypothesized to provide a link between the social environment and disease development. The purpose of this study was to examine associations between life course measures of socioeconomic status (SES) a ... Full text Link to item Cite

Drug-Gene Interactions of Antihypertensive Medications and Risk of Incident Cardiovascular Disease: A Pharmacogenomics Study from the CHARGE Consortium.

Journal Article PLoS One · 2015 BACKGROUND: Hypertension is a major risk factor for a spectrum of cardiovascular diseases (CVD), including myocardial infarction, sudden death, and stroke. In the US, over 65 million people have high blood pressure and a large proportion of these individua ... Full text Link to item Cite

Pleiotropy among common genetic loci identified for cardiometabolic disorders and C-reactive protein.

Journal Article PLoS One · 2015 Pleiotropic genetic variants have independent effects on different phenotypes. C-reactive protein (CRP) is associated with several cardiometabolic phenotypes. Shared genetic backgrounds may partially underlie these associations. We conducted a genome-wide ... Full text Link to item Cite

Penalized multimarker vs. single-marker regression methods for genome-wide association studies of quantitative traits.

Journal Article Genetics · January 2015 The data from genome-wide association studies (GWAS) in humans are still predominantly analyzed using single-marker association methods. As an alternative to single-marker analysis (SMA), all or subsets of markers can be tested simultaneously. This approac ... Full text Link to item Cite

Genetic diversity is a predictor of mortality in humans.

Journal Article BMC Genet · December 29, 2014 BACKGROUND: It has been well-established, both by population genetics theory and direct observation in many organisms, that increased genetic diversity provides a survival advantage. However, given the limitations of both sample size and genome-wide metric ... Full text Link to item Cite

FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals.

Journal Article Hum Mol Genet · December 20, 2014 FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is comp ... Full text Link to item Cite

Meta-analysis of genome-wide association studies for circulating phylloquinone concentrations.

Journal Article Am J Clin Nutr · December 2014 BACKGROUND: Poor vitamin K status is linked to greater risk of several chronic diseases. Age, sex, and diet are determinants of circulating vitamin K; however, there is still large unexplained interindividual variability in vitamin K status. Although a str ... Full text Link to item Cite

Age-related variations in the methylome associated with gene expression in human monocytes and T cells.

Journal Article Nat Commun · November 18, 2014 Age-related variations in DNA methylation have been reported; however, the functional relevance of these differentially methylated sites (age-dMS) are unclear. Here we report potentially functional age-dMS, defined as age- and cis-gene expression-associate ... Full text Link to item Cite

Defining the role of common variation in the genomic and biological architecture of adult human height.

Journal Article Nat Genet · November 2014 Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that th ... Full text Link to item Cite

miRNA-1: functional roles and dysregulation in heart disease.

Journal Article Molecular bioSystems · November 2014 microRNAs (miRNAs) are a class of small non-coding RNA molecules consisting of 19-22 nucleotides that play an important role in a variety of biological processes, including development, differentiation, apoptosis, cell proliferation and cellular senescence ... Full text Cite

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.

Journal Article Nat Commun · October 28, 2014 Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWA ... Full text Link to item Cite

Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation.

Journal Article Circulation · October 7, 2014 BACKGROUND: Atrial fibrillation (AF) affects >30 million individuals worldwide and is associated with an increased risk of stroke, heart failure, and death. AF is highly heritable, yet the genetic basis for the arrhythmia remains incompletely understood. M ... Full text Link to item Cite

Polygenic scores associated with educational attainment in adults predict educational achievement and ADHD symptoms in children.

Journal Article Am J Med Genet B Neuropsychiatr Genet · September 2014 The American Psychiatric Association estimates that 3 to 7 per cent of all school aged children are diagnosed with attention deficit hyperactivity disorder (ADHD). Even after correcting for general cognitive ability, numerous studies report a negative asso ... Full text Link to item Cite

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

Journal Article Nat Genet · August 2014 The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially leth ... Full text Link to item Cite

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.

Journal Article PLoS Genet · August 2014 Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GW ... Full text Link to item Cite

Genome-wide association analysis identifies six new loci associated with forced vital capacity.

Journal Article Nat Genet · July 2014 Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and foll ... Full text Link to item Cite

Meta-analysis of loci associated with age at natural menopause in African-American women.

Journal Article Hum Mol Genet · June 15, 2014 Age at menopause marks the end of a woman's reproductive life and its timing associates with risks for cancer, cardiovascular and bone disorders. GWAS and candidate gene studies conducted in women of European ancestry have identified 27 loci associated wit ... Full text Link to item Cite

Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium.

Journal Article Hum Mol Genet · June 1, 2014 Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We perfor ... Full text Link to item Cite

Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS).

Journal Article Metabolism · April 2014 OBJECTIVE: Glycated hemoglobin (HbA1c) is a stable index of chronic glycemic status and hyperglycemia associated with progressive development of insulin resistance and frank diabetes. It is also associated with premature aging and increased mortality. To u ... Full text Link to item Cite

Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.

Journal Article Am J Hum Genet · February 6, 2014 Low-frequency coding DNA sequence variants in the proprotein convertase subtilisin/kexin type 9 gene (PCSK9) lower plasma low-density lipoprotein cholesterol (LDL-C), protect against risk of coronary heart disease (CHD), and have prompted the development o ... Full text Link to item Cite

Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol.

Journal Article Am J Hum Genet · February 6, 2014 Elevated low-density lipoprotein cholesterol (LDL-C) is a treatable, heritable risk factor for cardiovascular disease. Genome-wide association studies (GWASs) have identified 157 variants associated with lipid levels but are not well suited to assess the i ... Full text Link to item Cite

Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval.

Journal Article Pharmacogenomics J · February 2014 Variability in response to drug use is common and heritable, suggesting that genome-wide pharmacogenomics studies may help explain the 'missing heritability' of complex traits. Here, we describe four independent analyses in 33 781 participants of European ... Full text Link to item Cite

Mitochondrial DNA sequence associations with dementia and amyloid-β in elderly African Americans.

Journal Article Neurobiol Aging · February 2014 Mitochondrial dysfunction occurs early in the course of several neurodegenerative diseases, and is potentially related to increased oxidative damage and amyloid-β (Aβ) formation in Alzheimer's disease. The goals of this study were to assess mtDNA sequence ... Full text Link to item Cite

Prospective associations of coronary heart disease loci in African Americans using the MetaboChip: the PAGE study.

Journal Article PLoS One · 2014 BACKGROUND: Coronary heart disease (CHD) is a leading cause of morbidity and mortality in African Americans. However, there is a paucity of studies assessing genetic determinants of CHD in African Americans. We examined the association of published variant ... Full text Link to item Cite

Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function.

Journal Article PLoS One · 2014 BACKGROUND: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function. METHODS: We performed GWAS of the rate of change in ... Full text Link to item Cite

Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions.

Journal Article PLoS One · 2014 Common genetic variants 3' of MC4R within two large linkage disequilibrium (LD) blocks spanning 288 kb have been associated with common and rare forms of obesity. This large association region has not been refined and the relevant DNA segments within the a ... Full text Link to item Cite

Association of a cystatin C gene variant with cystatin C levels, CKD, and risk of incident cardiovascular disease and mortality.

Journal Article Am J Kidney Dis · January 2014 BACKGROUND: Carriers of the T allele of the single-nucleotide polymorphism rs13038305 tend to have lower cystatin C levels and higher cystatin C-based estimated glomerular filtration rate (eGFRcys). Adjusting for this genetic effect on cystatin C concentra ... Full text Link to item Cite

Methylomics of gene expression in human monocytes.

Journal Article Hum Mol Genet · December 15, 2013 DNA methylation is one of several epigenetic mechanisms that contribute to the regulation of gene expression; however, the extent to which methylation of CpG dinucleotides correlates with gene expression at the genome-wide level is still largely unknown. U ... Full text Link to item Cite

Common variants in Mendelian kidney disease genes and their association with renal function.

Journal Article J Am Soc Nephrol · December 2013 Many common genetic variants identified by genome-wide association studies for complex traits map to genes previously linked to rare inherited Mendelian disorders. A systematic analysis of common single-nucleotide polymorphisms (SNPs) in genes responsible ... Full text Link to item Cite

Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function.

Journal Article BMC Med Genet · November 25, 2013 BACKGROUND: Vitamin D is associated with lung health in epidemiologic studies, but mechanisms mediating observed associations are poorly understood. This study explores mechanisms for an effect of vitamin D in lung through an in vivo gene expression study, ... Full text Link to item Cite

Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations.

Journal Article Am J Hum Genet · September 5, 2013 High blood pressure (BP) is more prevalent and contributes to more severe manifestations of cardiovascular disease (CVD) in African Americans than in any other United States ethnic group. Several small African-ancestry (AA) BP genome-wide association studi ... Full text Link to item Cite

Lipoprotein receptor-related protein 1 variants and dietary fatty acids: meta-analysis of European origin and African American studies.

Journal Article Int J Obes (Lond) · September 2013 OBJECTIVE: Low-density lipoprotein-related receptor protein 1 (LRP1) is a multi-functional endocytic receptor and signaling molecule that is expressed in adipose and the hypothalamus. Evidence for a role of LRP1 in adiposity is accumulating from animal and ... Full text Link to item Cite

Single-nucleotide polymorphism of the pri-miR-34b/c gene is not associated with susceptibility to congenital heart disease in the Han Chinese population.

Journal Article Genet Mol Res · August 12, 2013 Recent evidence has shown that the microRNA polymorphism may play an important role in the susceptibility to congenital heart disease (CHD). A potentially functional SNP rs4938723 (T>C) in the promoter region of pri-miR-34b/c might affect transcription fac ... Full text Link to item Cite

Association of heat shock proteins with all-cause mortality.

Journal Article Age (Dordr) · August 2013 Experimental mild heat shock is widely known as an intervention that results in extended longevity in various models along the evolutionary lineage. Heat shock proteins (HSPs) are highly upregulated immediately after a heat shock. The elevation in HSP leve ... Full text Link to item Cite

[Diversity changes of TCRVbeta gene in AIDS patients with incomplete immune reconstitution and influence of drug].

Journal Article Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica · August 2013 ObjectiveTo discuss the drug intervention in diversity changes of TCRVbeta gene in AIDS patients with incomplete immune reconstitution.MethodPBMCs were isolated from 37 cases of AIDS patients failure to immune reconstitution before and af ... Cite

[Study of drug intervention in diversity changes of TCRVbeta gene in AIDS patients with incomplete immune reconstitution].

Journal Article Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica · August 2013 ObjectiveTo discuss the drug intervention in diversity changes of TCRVbeta gene in AIDS patients with incomplete immune reconstitution.MethodPBMCs were isolated from 37 cases of AIDS patients failure to immune reconstitution before and af ... Cite

Chinese herbal medicine Qi Ju di Huang Wan for the treatment of essential hypertension: A systematic review of randomized controlled trials

Journal Article Evidence-based Complementary and Alternative Medicine · July 19, 2013 Background. Chinese herbs are potentially effective for hypertension. Qi Ju Di Huang Wan (QJDHW) is a commonly used Chinese herbal medicine as a monotherapy or in combination with other antihypertensive agents for the treatment of essential hypertension (E ... Full text Cite

Chinese herbal formulas for treating hypertension in traditional Chinese medicine: perspective of modern science.

Journal Article Hypertension research : official journal of the Japanese Society of Hypertension · July 2013 Hypertension, which directly threatens quality of life, is a major contributor to cardiovascular and cerebrovascular events. Over the past two decades, domestic and foreign scholars have agreed upon various standards in the treatment of hypertension, and c ... Full text Cite

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.

Journal Article Nat Genet · June 2013 Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and ... Full text Link to item Cite

Exploring the genetic basis of chronic periodontitis: a genome-wide association study.

Journal Article Hum Mol Genet · June 1, 2013 Chronic periodontitis (CP) is a common oral disease that confers substantial systemic inflammatory and microbial burden and is a major cause of tooth loss. Here, we present the results of a genome-wide association study of CP that was carried out in a coho ... Full text Link to item Cite

Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake.

Journal Article Am J Clin Nutr · June 2013 BACKGROUND: Macronutrient intake varies substantially between individuals, and there is evidence that this variation is partly accounted for by genetic variants. OBJECTIVE: The objective of the study was to identify common genetic variants that are associa ... Full text Link to item Cite

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.

Journal Article Nat Genet · June 2013 Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and confir ... Full text Link to item Cite

Tianma Gouteng Yin as adjunctive treatment for essential hypertension: A systematic review of randomized controlled trials

Journal Article Evidence-based Complementary and Alternative Medicine · May 27, 2013 Background. Tianma Gouteng Yin (TGY) is widely used for essential hypertension (EH) as adjunctive treatment. Many randomized clinical trials (RCTs) of TGY for EH have been published. However, it has not been evaluated to justify their clinical use and reco ... Full text Cite

Genetic variation associated with circulating monocyte count in the eMERGE Network.

Journal Article Hum Mol Genet · May 15, 2013 With white blood cell count emerging as an important risk factor for chronic inflammatory diseases, genetic associations of differential leukocyte types, specifically monocyte count, are providing novel candidate genes and pathways to further investigate. ... Full text Link to item Cite

A genome-wide association study of depressive symptoms.

Journal Article Biol Psychiatry · April 1, 2013 BACKGROUND: Depression is a heritable trait that exists on a continuum of varying severity and duration. Yet, the search for genetic variants associated with depression has had few successes. We exploit the entire continuum of depression to find common var ... Full text Link to item Cite

Common genetic variation near the connexin-43 gene is associated with resting heart rate in African Americans: a genome-wide association study of 13,372 participants.

Journal Article Heart Rhythm · March 2013 BACKGROUND: Genome-wide association studies have identified several genetic loci associated with variation in resting heart rate in European and Asian populations. No study has evaluated genetic variants associated with heart rate in African Americans. OBJ ... Full text Link to item Cite

Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies.

Journal Article J Nutr · March 2013 Favorable associations between magnesium intake and glycemic traits, such as fasting glucose and insulin, are observed in observational and clinical studies, but whether genetic variation affects these associations is largely unknown. We hypothesized that ... Full text Link to item Cite

Genetic associations with valvular calcification and aortic stenosis.

Journal Article N Engl J Med · February 7, 2013 BACKGROUND: Limited information is available regarding genetic contributions to valvular calcification, which is an important precursor of clinical valve disease. METHODS: We determined genomewide associations with the presence of aortic-valve calcificatio ... Full text Link to item Cite

Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts.

Journal Article Am J Epidemiol · January 15, 2013 Whether loci that influence fasting glucose (FG) and fasting insulin (FI) levels, as identified by genome-wide association studies, modify associations of diet with FG or FI is unknown. We utilized data from 15 U.S. and European cohort studies comprising 5 ... Full text Link to item Cite

Gain-of-function lipoprotein lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site.

Journal Article Am J Hum Genet · January 10, 2013 Genome-wide association studies (GWAS) have identified hundreds of genetic variants that are associated with lipid phenotypes. However, data supporting a functional role for these variants in the context of lipid metabolism are scarce. We investigated the ... Full text Link to item Cite

Genome-wide association of body fat distribution in African ancestry populations suggests new loci.

Journal Article PLoS Genet · 2013 Central obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker of body fat distribution. Although obesity disproportionately affects minority populations, few studies have conducted genome-wide association study (GWAS) of fat d ... Full text Link to item Cite

Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.

Journal Article PLoS Genet · 2013 Calcium is vital to the normal functioning of multiple organ systems and its serum concentration is tightly regulated. Apart from CASR, the genes associated with serum calcium are largely unknown. We conducted a genome-wide association meta-analysis of 39, ... Full text Link to item Cite

Social factors and leukocyte DNA methylation of repetitive sequences: the multi-ethnic study of atherosclerosis.

Journal Article PLoS One · 2013 Epigenetic changes are a potential mechanism contributing to race/ethnic and socioeconomic disparities in health. However, there is scant evidence of the race/ethnic and socioeconomic patterning of epigenetic marks. We used data from the Multi-Ethnic Study ... Full text Link to item Cite

Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium.

Journal Article PLoS One · 2013 Genotyping arrays are a cost effective approach when typing previously-identified genetic polymorphisms in large numbers of samples. One limitation of genotyping arrays with rare variants (e.g., minor allele frequency [MAF] <0.01) is the difficulty that au ... Full text Link to item Cite

Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function.

Journal Article Hum Mol Genet · December 15, 2012 In conducting genome-wide association studies (GWAS), analytical approaches leveraging biological information may further understanding of the pathophysiology of clinical traits. To discover novel associations with estimated glomerular filtration rate (eGF ... Full text Link to item Cite

Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans.

Journal Article Hum Mol Genet · December 15, 2012 Leukocyte telomere length (LTL) is associated with a number of common age-related diseases and is a heritable trait. Previous genome-wide association studies (GWASs) identified two loci on chromosomes 3q26.2 (TERC) and 10q24.33 (OBFC1) that are associated ... Full text Link to item Cite

Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.

Journal Article Blood · December 6, 2012 We conducted a genome-wide association study to identify novel associations between genetic variants and circulating plasminogen activator inhibitor-1 (PAI-1) concentration, and examined functional implications of variants and genes that were discovered. A ... Full text Link to item Cite

Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.

Journal Article Circ Cardiovasc Genet · December 2012 BACKGROUND: The PR interval, as measured by the resting, standard 12-lead ECG, reflects the duration of atrial/atrioventricular nodal depolarization. Substantial evidence exists for a genetic contribution to PR, including genome-wide association studies th ... Full text Link to item Cite

Impact of ancestry and common genetic variants on QT interval in African Americans.

Journal Article Circ Cardiovasc Genet · December 2012 BACKGROUND: Ethnic differences in cardiac arrhythmia incidence have been reported, with a particularly high incidence of sudden cardiac death and low incidence of atrial fibrillation in individuals of African ancestry. We tested the hypotheses that African ... Full text Link to item Cite

Genetic variants and associations of 25-hydroxyvitamin D concentrations with major clinical outcomes.

Journal Article JAMA · November 14, 2012 CONTEXT: Lower serum 25-hydroxyvitamin D concentrations are associated with greater risks of many chronic diseases across large, prospective community-based studies. Substrate 25-hydroxyvitamin D must be converted to 1,25-dihydroxyvitamin D for full biolog ... Full text Link to item Cite

Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels.

Journal Article Hum Mol Genet · November 1, 2012 Resistin is a polypeptide hormone that was reported to be associated with insulin resistance, inflammation and risk of type 2 diabetes and cardiovascular disease. We conducted a genome-wide association (GWA) study on circulating resistin levels in individu ... Full text Link to item Cite

Transferability and fine-mapping of glucose and insulin quantitative trait loci across populations: CARe, the Candidate Gene Association Resource.

Journal Article Diabetologia · November 2012 AIMS/HYPOTHESIS: Hyperglycaemia disproportionately affects African-Americans (AfAs). We tested the transferability of 18 single-nucleotide polymorphisms (SNPs) associated with glycaemic traits identified in European ancestry (EuA) populations in 5,984 non- ... Full text Link to item Cite

Discovery and fine mapping of serum protein loci through transethnic meta-analysis.

Journal Article Am J Hum Genet · October 5, 2012 Many disorders are associated with altered serum protein concentrations, including malnutrition, cancer, and cardiovascular, kidney, and inflammatory diseases. Although these protein concentrations are highly heritable, relatively little is known about the ... Full text Link to item Cite

Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.

Journal Article Am J Respir Crit Care Med · October 1, 2012 RATIONALE: Genome-wide association studies (GWAS) have identified loci influencing lung function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are known. OBJECTIVES: Perform meta-analyses of GWAS for airflow obstruction, a key p ... Full text Link to item Cite

Assessment of gene-by-sex interaction effect on bone mineral density.

Journal Article J Bone Miner Res · October 2012 Sexual dimorphism in various bone phenotypes, including bone mineral density (BMD), is widely observed; however, the extent to which genes explain these sex differences is unclear. To identify variants with different effects by sex, we examined gene-by-sex ... Full text Link to item Cite

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.

Journal Article Nat Genet · September 2012 Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, ... Full text Link to item Cite

The influence of abdominal visceral fat on inflammatory pathways and mortality risk in obstructive lung disease.

Journal Article Am J Clin Nutr · September 2012 BACKGROUND: Low-grade systemic inflammation, particularly elevated IL-6, predicts mortality in chronic obstructive pulmonary disease (COPD). Although altered body composition, especially increased visceral fat (VF) mass, could be a significant contributor ... Full text Link to item Cite

Effect of Yisui Shengxue Granule () on the oxidative damage of erythrocytes from patients with hemoglobin H disease.

Journal Article Chinese journal of integrative medicine · September 2012 ObjectiveTo investigate the effect of Yisui Shengxue Granule (, YSSXG), a complex Chinese medicine, on the oxidative damage of erythrocytes from patients with hemoglobin H (HbH) disease.MethodsTwenty-two patients with HbH disease and 22 h ... Full text Cite

Genome-wide association study validation identifies novel loci for atherosclerotic cardiovascular disease.

Journal Article J Thromb Haemost · August 2012 BACKGROUND: Genetic variants influencing lipid levels and risk of coronary artery disease (CAD) have been identified by recent genome-wide association studies (GWAS). OBJECTIVES: To test the association of single nucleotide polymorphisms (SNPs) implicated ... Full text Link to item Cite

Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.

Journal Article Nat Genet · July 15, 2012 Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide associatio ... Full text Link to item Cite

Anti-inflammation and antioxidant effect of Cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis, in middle cerebral artery occlusion-induced focal cerebral ischemia in rats.

Journal Article Metabolic brain disease · June 2012 Cordymin is a peptide purified from the medicinal mushroom Cordyceps sinensis. The present study investigated the effects of Cordymin in prevention of focal cerebral ischemic/reperfusion (IR) injury. The right middle cerebral artery occlusion model was use ... Full text Cite

Genome-wide meta-analyses of smoking behaviors in African Americans.

Journal Article Transl Psychiatry · May 22, 2012 The identification and exploration of genetic loci that influence smoking behaviors have been conducted primarily in populations of the European ancestry. Here we report results of the first genome-wide association study meta-analysis of smoking behavior i ... Full text Link to item Cite

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.

Journal Article Nat Genet · May 13, 2012 Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin resistance. We hypothesized that gen ... Full text Link to item Cite

Meta-analysis identifies six new susceptibility loci for atrial fibrillation.

Journal Article Nat Genet · April 29, 2012 Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death. We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibril ... Full text Link to item Cite

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.

Journal Article Nat Genet · April 15, 2012 Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asi ... Full text Link to item Cite

Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians.

Journal Article Diabetologia · April 2012 AIMS/HYPOTHESIS: FTO harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for FTO in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent. To ... Full text Link to item Cite

[Protective effect of combined administration blood-activating drug and sedative drug on acute myocardial infarction rats].

Journal Article Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica · April 2012 ObjectiveTo observe the protective effect of combined administration of blood-activating drug and sedative drug on myocardial injury of acute myocardial infarction (AMI) rats.MethodThe acute myocardial infarction (AMI) model was establish ... Cite

Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium.

Journal Article Circ Cardiovasc Genet · February 1, 2012 BACKGROUND: Carotid-femoral pulse wave velocity (CFPWV) is a heritable measure of aortic stiffness that is strongly associated with increased risk for major cardiovascular disease events. METHODS AND RESULTS: We conducted a meta-analysis of genome-wide ass ... Full text Link to item Cite

Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies.

Journal Article Circ Cardiovasc Genet · February 1, 2012 BACKGROUND: Genetic determinants of peripheral arterial disease (PAD) remain largely unknown. To identify genetic variants associated with the ankle-brachial index (ABI), a noninvasive measure of PAD, we conducted a meta-analysis of genome-wide association ... Full text Link to item Cite

A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.

Journal Article PLoS Genet · 2012 Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and ... Full text Link to item Cite

Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations.

Journal Article PLoS One · 2012 Meta-analyses of European populations has successfully identified genetic variants in over 100 loci associated with lipid levels, but our knowledge in other ethnicities remains limited. To address this, we performed dense genotyping of ∼2,000 candidate gen ... Full text Link to item Cite

Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.

Journal Article PLoS Genet · 2012 Genome-wide association studies have identified numerous genetic loci for spirometic measures of pulmonary function, forced expiratory volume in one second (FEV(1)), and its ratio to forced vital capacity (FEV(1)/FVC). Given that cigarette smoking adversel ... Full text Link to item Cite

Mitochondrial DNA sequence variation associated with dementia and cognitive function in the elderly.

Journal Article J Alzheimers Dis · 2012 Mitochondrial dysfunction is a prominent hallmark of Alzheimer's disease (AD). Mitochondrial DNA (mtDNA) damage may be a major cause of abnormal reactive oxidative species production in AD or increased neuronal susceptibility to oxidative injury during agi ... Full text Link to item Cite

Genome-wide association of pericardial fat identifies a unique locus for ectopic fat.

Journal Article PLoS Genet · 2012 Pericardial fat is a localized fat depot associated with coronary artery calcium and myocardial infarction. We hypothesized that genetic loci would be associated with pericardial fat independent of other body fat depots. Pericardial fat was quantified in 5 ... Full text Link to item Cite

Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.

Journal Article PLoS Genet · 2012 Body fat distribution, particularly centralized obesity, is associated with metabolic risk above and beyond total adiposity. We performed genome-wide association of abdominal adipose depots quantified using computed tomography (CT) to uncover novel loci fo ... Full text Link to item Cite

Genetic ancestry-smoking interactions and lung function in African Americans: a cohort study.

Journal Article PLoS One · 2012 BACKGROUND: Smoking tobacco reduces lung function. African Americans have both lower lung function and decreased metabolism of tobacco smoke compared to European Americans. African ancestry is also associated with lower pulmonary function in African Americ ... Full text Link to item Cite

A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.

Journal Article PLoS Genet · 2012 Several genetic variants associated with platelet count and mean platelet volume (MPV) were recently reported in people of European ancestry. In this meta-analysis of 7 genome-wide association studies (GWAS) enrolling African Americans, our aim was to iden ... Full text Link to item Cite

Genome-wide association and functional follow-up reveals new loci for kidney function.

Journal Article PLoS Genet · 2012 Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new l ... Full text Link to item Cite

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.

Journal Article PLoS Genet · 2012 Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association stu ... Full text Link to item Cite

Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction.

Journal Article Circulation · December 20, 2011 BACKGROUND: Coronary artery calcification (CAC) detected by computed tomography is a noninvasive measure of coronary atherosclerosis, which underlies most cases of myocardial infarction (MI). We sought to identify common genetic variants associated with CA ... Full text Link to item Cite

Inflammation and the paradox of racial differences in dialysis survival.

Journal Article J Am Soc Nephrol · December 2011 African Americans experience a higher mortality rate and an excess burden of ESRD compared with Caucasians in the general population, but among those treated with dialysis, African Americans typically survive longer than Caucasians. We examined whether dif ... Full text Link to item Cite

Mitochondrial DNA variation in human metabolic rate and energy expenditure.

Journal Article Mitochondrion · November 2011 The role of climate in driving selection of mtDNA as Homo sapiens migrated out of Africa into Eurasia remains controversial. We evaluated the role of mtDNA variation in resting metabolic rate (RMR) and total energy expenditure (TEE) among 294 older, commun ... Full text Link to item Cite

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.

Journal Article Nat Genet · October 16, 2011 Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are n ... Full text Link to item Cite

Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.

Journal Article PLoS Genet · October 2011 Adult height is a classic polygenic trait of high heritability (h(2) approximately 0.8). More than 180 single nucleotide polymorphisms (SNPs), identified mostly in populations of European descent, are associated with height. These variants convey modest ef ... Full text Link to item Cite

Genetic determinants of serum testosterone concentrations in men.

Conference PLoS Genet · October 2011 Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide assoc ... Full text Link to item Cite

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

Journal Article Nat Genet · September 25, 2011 Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second ... Full text Link to item Cite

Vanadium-enriched cordyceps sinensis, a contemporary treatment approach to both diabetes and depression in rats

Journal Article Evidence-based Complementary and Alternative Medicine · September 19, 2011 This article studies a contemporary treatment approach toward both diabetes and depression management by vanadium-enriched Cordyceps sinensis (VECS). Streptozotocin-induced hyperglycemic rats were used in the study. After the rats were administered with VE ... Full text Cite

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

Journal Article Nature · September 11, 2011 Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or  ≥90 mm Hg diastolic blood pressure). Even sma ... Full text Link to item Cite

Genetic association for renal traits among participants of African ancestry reveals new loci for renal function.

Journal Article PLoS Genet · September 2011 Chronic kidney disease (CKD) is an increasing global public health concern, particularly among populations of African ancestry. We performed an interrogation of known renal loci, genome-wide association (GWA), and IBC candidate-gene SNP association analyse ... Full text Link to item Cite

Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis.

Journal Article Diabetes · September 2011 OBJECTIVE: Many genetic variants have been associated with glucose homeostasis and type 2 diabetes in genome-wide association studies. Zinc is an essential micronutrient that is important for β-cell function and glucose homeostasis. We tested the hypothesi ... Full text Link to item Cite

Common variants in the periostin gene influence development of atherosclerosis in young persons.

Journal Article Arterioscler Thromb Vasc Biol · July 2011 OBJECTIVE: We investigated the influence of genetic variants (rare and common) in the gene encoding periostin (POSTN) on atherosclerosis as measured in arterial specimens from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. METHO ... Full text Link to item Cite

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.

Journal Article Nat Genet · June 26, 2011 Genome-wide association studies have identified 32 loci influencing body mass index, but this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta-analyzed associations between ∼2.5 million SNPs and body fat percentage from ... Full text Link to item Cite

Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT).

Journal Article PLoS Genet · June 2011 Total white blood cell (WBC) and neutrophil counts are lower among individuals of African descent due to the common African-derived "null" variant of the Duffy Antigen Receptor for Chemokines (DARC) gene. Additional common genetic polymorphisms were recent ... Full text Link to item Cite

Multiple loci are associated with white blood cell phenotypes.

Journal Article PLoS Genet · June 2011 White blood cell (WBC) count is a common clinical measure from complete blood count assays, and it varies widely among healthy individuals. Total WBC count and its constituent subtypes have been shown to be moderately heritable, with the heritability estim ... Full text Link to item Cite

Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.

Conference PLoS Genet · April 2011 Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands--yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led to speculation that a relative DHEAS ... Full text Link to item Cite

CUBN is a gene locus for albuminuria.

Journal Article J Am Soc Nephrol · March 2011 Identification of genetic risk factors for albuminuria may alter strategies for early prevention of CKD progression, particularly among patients with diabetes. Little is known about the influence of common genetic variants on albuminuria in both general an ... Full text Link to item Cite

Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.

Journal Article Circulation · February 22, 2011 BACKGROUND: C-reactive protein (CRP) is a heritable marker of chronic inflammation that is strongly associated with cardiovascular disease. We sought to identify genetic variants that are associated with CRP levels. METHODS AND RESULTS: We performed a geno ... Full text Link to item Cite

Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data.

Journal Article BMJ · February 15, 2011 OBJECTIVE: To use genetic variants as unconfounded proxies of C reactive protein concentration to study its causal role in coronary heart disease. DESIGN: Mendelian randomisation meta-analysis of individual participant data from 47 epidemiological studies ... Full text Link to item Cite

Genome-wide association studies of the PR interval in African Americans.

Journal Article PLoS Genet · February 10, 2011 The PR interval on the electrocardiogram reflects atrial and atrioventricular nodal conduction time. The PR interval is heritable, provides important information about arrhythmia risk, and has been suggested to differ among human races. Genome-wide associa ... Full text Link to item Cite

Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.

Journal Article PLoS Genet · February 10, 2011 Coronary heart disease (CHD) is the leading cause of mortality in African Americans. To identify common genetic polymorphisms associated with CHD and its risk factors (LDL- and HDL-cholesterol (LDL-C and HDL-C), hypertension, smoking, and type-2 diabetes) ... Full text Link to item Cite

Meta-analysis of gene-environment interaction: joint estimation of SNP and SNP × environment regression coefficients.

Journal Article Genet Epidemiol · January 2011 INTRODUCTION: Genetic discoveries are validated through the meta-analysis of genome-wide association scans in large international consortia. Because environmental variables may interact with genetic factors, investigation of differing genetic effects for d ... Full text Link to item Cite

A genome-wide association study of aging

Journal Article Neurobiology of Aging · 2011 Full text Link to item Cite

Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies.

Journal Article Diabetes Care · December 2010 OBJECTIVE: Whole-grain foods are touted for multiple health benefits, including enhancing insulin sensitivity and reducing type 2 diabetes risk. Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) as ... Full text Link to item Cite

[Effects of Chinese herbal medicine Yiqi Huoxue Formula on TGF-β/smad signal transduction pathway and connective tissue growth factor in rats with renal interstitial fibrosis].

Journal Article Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine · December 2010 ObjectiveTo observe the effects of Yiqi Huoxue Formula (YQHXF), a compound Chinese herbal medicine, on transforming growth factor-β (TGF-β)/smad signal transduction pathway and connective tissue growth factor (CTGF) in rats with renal interstitial ... Full text Cite

Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.

Journal Article Hum Mol Genet · November 1, 2010 Serum calcium levels are tightly regulated. We performed genome-wide association studies (GWAS) in population-based studies participating in the CHARGE Consortium to uncover common genetic variations associated with total serum calcium levels. GWAS of seru ... Full text Link to item Cite

Common genetic determinants of vitamin D insufficiency: a genome-wide association study.

Journal Article Lancet · July 17, 2010 BACKGROUND: Vitamin D is crucial for maintenance of musculoskeletal health, and might also have a role in extraskeletal tissues. Determinants of circulating 25-hydroxyvitamin D concentrations include sun exposure and diet, but high heritability suggests th ... Full text Link to item Cite

The effects of corn silk on glycaemic metabolism

Journal Article Nutrition and Metabolism · December 28, 2009 Background. Corn silk contains proteins, vitamins, carbohydrates, Ca, K, Mg and Na salts, fixed and volatile oils, steroids such as sitosterol and stigmasterol, alkaloids, saponins, tannins, and flavonoids. Base on folk remedies, corn silk has been used as ... Full text Cite

A functional polymorphism in the lymphotoxin-alpha gene is associated with carotid artery wall thickness: the Diabetes Heart Study.

Journal Article Eur J Cardiovasc Prev Rehabil · August 2006 BACKGROUND: The lymphotoxin-alpha (LTA) gene has been implicated in the pathogenesis of atherosclerosis. We tested for an association between a functional polymorphism, LTA 252A/G, and common carotid artery intima-media thickness in 1088 siblings from 435 ... Full text Link to item Cite

Haplotype of signal transducer and activator of transcription 3 gene predicts cardiovascular disease in dialysis patients.

Journal Article J Am Soc Nephrol · August 2006 Signal transducer and activator of transcription 3 (STAT3) protein has been linked to cardiovascular disease (CVD) through multiple pathways in experimental and animal studies. STAT3 gene variation was examined as a predictor of incident CVD in a subcohort ... Full text Link to item Cite

Temporal relation among depression symptoms, cardiovascular disease events, and mortality in end-stage renal disease: contribution of reverse causality.

Journal Article Clin J Am Soc Nephrol · May 2006 Temporal relationships among depression, medical comorbidity, and death or cardiovascular disease (CVD) events are complex. Clarifying temporal relationships may enhance current insight regarding the nature of the association of depression with poor outcom ... Full text Link to item Cite