Scholars@Duke
Yuichiro Yano

Yuichiro Yano

Adjunct Professor in the Department of Family Medicine and Community Health
Family Medicine and Community Health

Selected Publications

Current Status and Future Perspective of Onco-Hypertension.

Journal Article Am J Hypertens · December 16, 2024 BACKGROUND: Hypertension and cancer are both increasing with age. Recently, the new concept of "Onco-Hypertension" has been proposed to address the mutual risks posed by hypertension and cancer and to provide comprehensive care for patients with these two ... Full text Link to item Cite

BP classification using the 2017 ACC/AHA BP guidelines with risk of cardiovascular events in older individuals.

Journal Article J Cardiol · December 2024 BACKGROUND: The association between stage 1 hypertension and the risk of cardiovascular disease (CVD) has not been established in older adults. Furthermore, little is known about whether lowering blood pressure (BP) is beneficial in older adults with stage ... Full text Link to item Cite

Hypertension in children and adolescents: perspectives in Japan.

Other Hypertens Res · December 2024 Hypertension in children and adolescents is associated with increased risk of hypertension and cardiovascular disease (CVD) in adulthood. Therefore, preventing hypertension among children and adolescents is an important public health objective worldwide. A ... Full text Link to item Cite

Practical use and target value of urine sodium-to-potassium ratio in assessment of hypertension risk for Japanese: Consensus Statement by the Japanese Society of Hypertension Working Group on Urine Sodium-to-Potassium Ratio.

Journal Article Hypertens Res · December 2024 Epidemiological studies have demonstrated that the urine sodium-to-potassium (Na/K) ratio is more positively associated with high blood pressure and cardiovascular disease risk than either urine sodium or potassium excretion alone. In this consensus statem ... Full text Link to item Cite

Oral microbiome alpha diversity and all-cause, cardiovascular, and non-cardiovascular mortality in US adults: Evidence from the NHANES 2009-2019.

Journal Article Atherosclerosis · November 29, 2024 BACKGROUND AND AIMS: Knowledge about the association between oral microbiome diversity within individuals and cardiovascular disease (CVD) and non-CVD mortality is scarce. Besides, variation by sex and racial and ethnic groups, and the potential mediators ... Full text Link to item Cite

Association between proteinuria and mineral metabolism disorders in chronic kidney disease: the Japan chronic kidney disease database extension (J-CKD-DB-Ex).

Journal Article Sci Rep · November 11, 2024 Chronic kidney disease-mineral and bone disorder (CKD-MBD) are recognized as a systemic disease affecting the prognosis of patients with CKD. Proper management of CKD-MBD is important to improve the prognosis of patients with CKD. Although proteinuria is r ... Full text Link to item Cite

Using a Quality Management System and Risk-based Approach in Observational Studies to Obtain Robust Real-World Evidence.

Journal Article Ther Innov Regul Sci · November 2024 The results of observational studies using real-world data, known as real-world evidence, have gradually started to be used in drug development and decision-making by policymakers. A good quality management system-a comprehensive system of process, data, a ... Full text Link to item Cite

Awareness of Being Prescribed Antihypertensive Medications and Cardiovascular Outcomes.

Journal Article Circ J · September 25, 2024 BACKGROUND: Hypertension is a major cause of cardiovascular disease (CVD). In patients with hypertension, unawareness of the disease often results in poor blood pressure control and increases the risk of CVD. However, data in nationwide surveys regarding t ... Full text Link to item Cite

Remembering Dr. George L. Bakris: A pillar of cardiorenal medicine and mentorship

Journal Article American Journal of Preventive Cardiology · September 1, 2024 Full text Cite

Association of serum magnesium levels with renal prognosis in patients with chronic kidney disease.

Journal Article Clin Exp Nephrol · August 2024 BACKGROUND: Magnesium deficiency is associated with various health conditions, but its impact on the progression of chronic kidney disease (CKD) remains unclear. This study aimed to investigate the association between serum magnesium levels and prognosis o ... Full text Link to item Cite

Heterogeneous Effects of Intensive Glycemic and Blood Pressure on Cardiovascular Events Among Diabetes by Living Arrangements.

Journal Article J Am Heart Assoc · July 2, 2024 BACKGROUND: Although living alone versus with others is a key social element for cardiovascular prevention in diabetes, evidence is lacking about whether the benefit of intensive glycemic and blood pressure (BP) control differs by living arrangements. We t ... Full text Link to item Cite

Comparison of incident hypertension between SGLT2 inhibitors vs. DPP4 inhibitors.

Journal Article Hypertens Res · July 2024 Although several randomized clinical trials have reported the potential benefit of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in reducing blood pressure (BP), whether SGLT2i can reduce incident hypertension is unknown. We analyzed individuals with ... Full text Link to item Cite

Risk of cancer history in cardiovascular disease among individuals with hypertension.

Journal Article Hypertens Res · July 2024 Hypertension is the leading risk factor for cardiovascular disease (CVD). Although cancer has recently been increasingly recognized as a novel risk factor for CVD events, little is known about whether co-morbid cancer in individuals with hypertension could ... Full text Link to item Cite

Factors affecting the sodium-glucose cotransporter 2 inhibitors-related initial decline in glomerular filtration rate and its possible effect on kidney outcome in chronic kidney disease with type 2 diabetes: The Japan Chronic Kidney Disease Database.

Journal Article Diabetes Obes Metab · July 2024 AIM: Sodium-glucose cotransporter 2 (SGLT2) inhibitors often cause a transient decrease in glomerular filtration rate (GFR) shortly after the initiation, referred to as the 'initial drop'. However, the clinical significance of this initial drop in real-wor ... Full text Link to item Cite

Prologue: Special Spotlight Issue on Japan.

Journal Article J Hum Hypertens · June 2024 Full text Link to item Cite

Kidney outcomes of SGLT2 inhibitors among older patients with diabetic kidney disease in real-world clinical practice: the Japan Chronic Kidney Disease Database Ex.

Journal Article BMJ Open Diabetes Res Care · May 30, 2024 INTRODUCTION: We compared the kidney outcomes between patients with diabetic kidney disease (DKD) aged ≥75 years initiating sodium-glucose cotransporter 2 (SGLT2) inhibitors versus other glucose-lowering drugs, additionally presenting with or without prote ... Full text Link to item Cite

Association of cancer with the risk of developing hypertension.

Journal Article Eur Heart J Qual Care Clin Outcomes · May 22, 2024 BACKGROUND AND AIMS: Although the importance of hypertension in patients with cancer is widely recognized, little is known about the risk of developing hypertension in patients with a history of cancer. METHODS AND RESULTS: This retrospective observational ... Full text Link to item Cite

Evaluating the associations between compliance with CKD guideline component metrics and renal outcomes.

Journal Article Sci Rep · May 20, 2024 Understanding the association between compliance to the Chronic Kidney Disease (CKD) guidelines in real-world clinical settings and renal outcomes remains a critical gap in knowledge. A comprehensive analysis was conducted using data from a national, multi ... Full text Link to item Cite

Low-density lipoprotein particle profiles compared with standard lipids measurements in the association with asymptomatic intracranial artery stenosis.

Journal Article Sci Rep · May 10, 2024 The Shiga Epidemiological Study of Subclinical Atherosclerosis was conducted in Kusatsu City, Shiga, Japan, from 2006 to 2008. Participants were measured for LDL-p through nuclear magnetic resonance technology. 740 men participated in follow-up and underwe ... Full text Link to item Cite

Heart Rate Fragmentation, Ambulatory Blood Pressure, and Coronary Artery Calcification: A Population-Based Study

Journal Article JACC: Asia · March 1, 2024 Background: Little is known regarding whether ultra-rapid patterns of heart rate variability (eg, heart rate fragmentation [HRF]) are associated with coronary artery calcification (CAC) in a general population. Objectives: This study aimed to assess the as ... Full text Cite

Association of Pro-Inflammatory Diet with Long-Term Risk of All-Cause and Cardiovascular Disease Mortality: NIPPON DATA80.

Journal Article J Atheroscler Thromb · March 1, 2024 AIM: A pro-inflammatory diet may increase the risk of cardiovascular disease (CVD) and all-cause mortality. However, this remains inconclusive as there is yet no study using a dietary record method that has been conducted in a large general population. Fur ... Full text Link to item Cite

Race differences in ambulatory blood pressure monitoring parameters.

Journal Article Blood Press Monit · February 1, 2024 BACKGROUND: Mean systolic and diastolic blood pressure (SBP and DBP) on ambulatory blood pressure (BP) monitoring (ABPM) are higher among Black compared with White adults. With 48 to 72 BP measurements obtained over 24 h, ABPM can generate parameters other ... Full text Link to item Cite

Kidney outcomes associated with haematuria and proteinuria trajectories among patients with IgA nephropathy in real-world clinical practice: The Japan Chronic Kidney Disease Database.

Journal Article Nephrology (Carlton) · February 2024 AIM: Among patients with Immunoglobulin A (IgA) nephropathy, we aimed to identify trajectory patterns stratified by the magnitude of haematuria and proteinuria using repeated urine dipstick tests, and assess whether the trajectories were associated with ki ... Full text Link to item Cite

Higher-order Allan variance for atomic clocks of arbitrary order: mathematical foundation

Journal Article Metrologia · February 1, 2024 In this paper, we perform a time-domain analysis of the higher-order Allan variance for atomic clock models of arbitrary order. Adopting a standard atomic clock model where the time series of the clock reading deviation is expressed as a Wiener or integrat ... Full text Cite

Association of step counts with cognitive function in apparently healthy middle-aged and older Japanese men

Journal Article Preventive Medicine Reports · February 1, 2024 Background: Increasing physical activity may prevent cognitive decline. Previous studies primarily focused on older adults and used self-reported questionnaires to assess physical activity. We examined the relationship between step count, an objective meas ... Full text Cite

Alcohol Consumption and Cerebral Small- and Large-Vessel Diseases: A Mendelian Randomization Analysis.

Journal Article J Atheroscler Thromb · February 1, 2024 AIMS: It remains inconclusive regarding alcohol intake and stroke risk because determining risk factors depends on the specific pathogenesis of stroke. We used the variant rs671 in the aldehyde dehydrogenase 2 gene (ALDH2) as an instrument to investigate t ... Full text Link to item Cite

The gut microbiota and coronary artery calcification in Japanese men.

Journal Article Am Heart J · January 2024 BACKGROUND: The gut microbiota differs between patients with coronary artery disease (CAD) and healthy controls; however, it currently remains unclear whether these differences exist prior to the onset of CAD. We herein investigated the gut microbiota asso ... Full text Link to item Cite

Clinicopathological prognostic stratification for proteinuria and kidney survival in IgA nephropathy: a Japanese prospective cohort study.

Journal Article Clin Kidney J · January 2024 BACKGROUND: We require a clinicopathological risk stratification method for immunoglobulin A nephropathy (IgAN) to predict kidney outcomes. We examined a renal failure risk group (RF-RG) classification system created following a prior multicentre, retrospe ... Full text Link to item Cite

Association of Anthropometric and CT-Based Obesity Indices with Subclinical Atherosclerosis.

Journal Article J Atheroscler Thromb · January 1, 2024 AIM: Few studies have compared the strength in the associations of anthropometric and computed tomography (CT)-based obesity indices with coronary artery calcification (CAC), aortic artery calcification (AoAC), and aortic valve calcification (AVC). METHODS ... Full text Link to item Cite

Structured Kalman Filter for Time Scale Generation in Atomic Clock Ensembles

Journal Article IEEE Control Systems Letters · January 1, 2024 In this letter, we present a structured Kalman filter associated with the transformation matrix for observable Kalman canonical decomposition from conventional Kalman filter (CKF) in order to generate a more accurate time scale. The conventional Kalman fil ... Full text Cite

Association of gut microbiome with COPD in Japanese male residents: the SESSA study

Journal Article ERJ Open Research · January 1, 2024 Background Altered gut microbiota may contribute to COPD development or progression. Herein, we investigated the association of gut microorganisms with COPD, taking into account the impact of smoking status. Methods This cross-sectional observational study ... Full text Cite

The association between employee lifestyles and the rates of mental health-related absenteeism and turnover in Japanese companies.

Journal Article Epidemiol Health · 2024 We assessed the association of employee lifestyles (e.g., smoking, exercise, drinking, and sleep habits) with mental health-related absenteeism and turnover rates utilizing data from the annual Health and Productivity Management survey by Japan's Ministry ... Full text Link to item Cite

Clinical Profile and Treatment Adherence in Patients with Type 2 Diabetes and Chronic Kidney Disease Who Initiate an SGLT2 Inhibitor: A Multi-cohort Study

Journal Article Diabetes Therapy · January 1, 2024 Introduction: The clinical landscape for the treatment of patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) is rapidly evolving. As part of the FOUNTAIN platform (NCT05526157; EUPAS48148), we described and compared cohorts of adult patie ... Full text Cite

Diagnostic Accuracy of Office Blood Pressure Measurement and Home Blood Pressure Monitoring for Hypertension Screening Among Adults: Results From the IDH Study.

Journal Article J Am Heart Assoc · December 19, 2023 BACKGROUND: Using high awake blood pressure (BP; ≥130/80 mm Hg) on ambulatory BP monitoring (ABPM) as a reference, the purpose of this study was to determine the accuracy of high office BP (≥130/80 mm Hg) at an initial visit and high confirmatory office BP ... Full text Link to item Cite

Light shift of Ramsey coherent population trapping resonance using drive current modulation

Journal Article Japanese Journal of Applied Physics · December 1, 2023 We investigated the light shift of Ramsey coherent population trapping (CPT) resonance by drive current modulation (DCM), which can be realized with low power consumption in a small system, to improve the performance of a CPT atomic clock. The light shift ... Full text Cite

Associations of corticosteroid therapy and tonsillectomy with kidney survival in a multicenter prospective study for IgA nephropathy.

Journal Article Sci Rep · October 27, 2023 Efficacy of systemic corticosteroid therapy (CS) for long-term kidney survival in patients with IgA nephropathy (IgAN) is controversial. Therefore, prospective studies evaluating targeted therapies to lymphatic tissues in mucosal immune system responsible ... Full text Link to item Cite

Association between Dietary Patterns and Serum Low Density Lipoprotein Cholesterol in Japanese Women and Men: The Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.

Journal Article J Atheroscler Thromb · October 1, 2023 AIMS: The association between dietary patterns and serum low density lipoprotein (LDL) cholesterol would be changing in recent dietary habits in Japan. We investigated the relationship between dietary patterns and serum LDL cholesterol in a large general p ... Full text Link to item Cite

Incidence and In-Hospital Mortality of Acute Myocardial Infarction: A Report from a Population-Based Registry in Japan.

Journal Article J Atheroscler Thromb · October 1, 2023 AIM: To investigate the incidence and in-hospital mortality of acute myocardial infarction (AMI) by conforming to the Universal Definition of Myocardial Infarction (UDMI) in a population-based registry. METHODS: The Shiga Stroke and Heart Attack Registry i ... Full text Link to item Cite

Race- and Sex-Specific Factors Associated With Age-Related Slopes in Systolic Blood Pressure: Findings From the CARDIA Study.

Journal Article Hypertension · September 2023 BACKGROUND: Although blood pressure (BP) increases throughout young adulthood for most individuals, the age-related slope is not uniform. This study aimed to assess associations of demographic, clinical, behavioral, psychosocial, and neighborhood character ... Full text Link to item Cite

Medication adherence and health-related quality of life among people with diabetes in Bangladesh: A cross-sectional study.

Journal Article Endocrinol Diabetes Metab · September 2023 INTRODUCTION: Good adherence to anti-diabetic medications is an important protective factor for decreasing diabetes-related complications and disabilities but its association with health-related quality of life (HRQoL) is understudied. The current study ai ... Full text Link to item Cite

Epidemiology of Acute Aortic Dissection in a General Population of 1.4 Million People in Japan　- Shiga Stroke and Heart Attack Registry.

Journal Article Circ J · August 25, 2023 BACKGROUND: Acute aortic dissection (AAD) is a life-threatening cardiovascular disease, with a reported incidence rate ranging from 2.5 to 7.2 per 100,000 person-years in several population-based registries in Western countries, but epidemiological data ar ... Full text Link to item Cite

Reduction in blood pressure for people with isolated diastolic hypertension and cardiovascular outcomes.

Journal Article Eur J Prev Cardiol · August 1, 2023 AIMS: Isolated diastolic hypertension (IDH) is a largely underrated risk factor for cardiovascular disease (CVD). It is currently unclear whether a reduction in blood pressure (BP) is associated with CVD events among adults with IDH. We aimed to elucidate ... Full text Link to item Cite

Relationship between Serum Irisin Levels and MRI-Measured Cerebral Small Vessel Disease in Japanese Men.

Journal Article J Atheroscler Thromb · August 1, 2023 AIM: Irisin, an exercise-induced myokine, is a potential neurotrophic factor; however, its relationship with cerebral small vessel disease (CSVD) remains unknown. Therefore, we investigated whether serum irisin levels are associated with CSVD in healthy Ja ... Full text Link to item Cite

Racial difference in the association between non-alcoholic fatty liver disease and incident type 2 diabetes: findings from the CARDIA study.

Journal Article Diabetologia · July 2023 AIMS/HYPOTHESIS: Type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) are prevalent diseases of metabolic origin. We examined the association between NAFLD and the development of type 2 diabetes among non-Asian adults, and whether the association ... Full text Link to item Cite

Future Prospects of Onco-Hypertension.

Journal Article Hypertension · July 2023 Full text Link to item Cite

Relationship between Serum Proprotein Convertase Subtilisin/Kexin Type 9 Concentration and Prevalence of Coronary Artery Calcium in a Community-Based Sample of Japanese Men.

Journal Article J Atheroscler Thromb · July 1, 2023 AIMS: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising new target for reducing low-density lipoprotein cholesterol (LDL-C) and cardiovascular events in high-risk patients. However, the influence of circulating PCSK9 concentration on ath ... Full text Link to item Cite

Evaluation of Stability of Higher-Order Atomic Clocks by Higher-Order Allan Variance

Conference IFAC-PapersOnLine · July 1, 2023 In this paper, we analyze a generalized version of the Allan variance, referred to as a higher-order Allan variance, that can evaluate the frequency stability of multi-dimensional atomic clocks as a function of the measurement interval. It is known that th ... Full text Cite

Association of Arterial Stiffness and Atherosclerotic Burden With Brain Structural Changes Among Japanese Men.

Journal Article J Am Heart Assoc · June 6, 2023 Background Little is known regarding whether arterial stiffness and atherosclerotic burden are each independently associated with brain structural changes. Simultaneous assessments of both arterial stiffness and atherosclerotic burden in associations with ... Full text Link to item Cite

Association between proprotein convertase subtilisin/kexin type 9 and subclinical cerebrovascular disease in the community.

Journal Article Eur J Neurol · May 2023 BACKGROUND AND PURPOSE: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a new target for reducing low-density lipoprotein cholesterol and incident cardiovascular disease, including stroke. However, the clinical relevance of circulating PCSK9 level ... Full text Link to item Cite

Association of Isolated Hypothyroxinemia and Subclinical Hypothyroidism With Birthweight: A Cohort Study in Japan

Journal Article Journal of the Endocrine Society · May 1, 2023 Context: Isolated hypothyroxinemia (low maternal free thyroxine [FT4] in the absence of thyroid-stimulating hormone [TSH] elevation) and subclinical hypothyroidism (high TSH in the absence of FT4 elevation) during early pregnancy are common. However, there ... Full text Cite

The association of BP with cardiovascular outcomes in patients with dipstick proteinuria and preserved kidney function.

Journal Article Hypertens Res · April 2023 Little is known about the relationship between blood pressure (BP) and incident cardiovascular disease (CVD) in people with proteinuria and a preserved estimated glomerular filtration rate (eGFR). This study sought to investigate the association of BP with ... Full text Link to item Cite

Sex Differences in the Association Between Hypertension and Incident Atrial Fibrillation.

Journal Article J Am Heart Assoc · March 7, 2023 Background Limited evidence is available on sex differences about the association between hypertension and incident atrial fibrillation (AF). Methods and Results We used a nationwide health checkup and claims database to analyze 3 383 738 adults (median ag ... Full text Link to item Cite

Blood Pressure Classification Using the 2017 ACC/AHA Guideline and Heart Failure in Patients With Cancer.

Journal Article J Clin Oncol · February 10, 2023 PURPOSE: Despite the growing recognition of the importance of hypertension in patients with cancer, little is known about whether high blood pressure (BP) among patients with cancer is associated with incident heart failure (HF) and other cardiovascular di ... Full text Link to item Cite

Age-Dependent Association Between Modifiable Risk Factors and Incident Cardiovascular Disease.

Journal Article J Am Heart Assoc · January 17, 2023 Background There have been limited data examining the age-dependent relationship of wide-range risk factors with the incidence of each subtype of cardiovascular disease (CVD) event. We assessed age-related associations between modifiable risk factors and t ... Full text Link to item Cite

Interaction of Blood Pressure and Glycemic Status in Developing Cardiovascular Disease: Analysis of a Nationwide Real-World Database.

Journal Article J Am Heart Assoc · January 3, 2023 Background Hypertension and diabetes frequently coexist. However, little is known about the interaction between high blood pressure (BP) and hyperglycemia in the development of cardiovascular disease (CVD). Methods and Results We conducted an observational ... Full text Link to item Cite

Volume–Outcome Relationship in Cancer Survival Rates: Analysis of a Regional Population-Based Cancer Registry in Japan

Journal Article Healthcare (Switzerland) · January 1, 2023 Background: There is limited data on the relationship between hospital volumes and outcomes with respect to cancer survival in Japan. The primary objective of this study was to evaluate the effect of hospital volume on cancer survival rate using a populati ... Full text Cite

Impact of FBAR Oscillator Stabilized to the CPT Resonance as Local Oscillator of Millimeter-Wave Communications

Conference IEEE International Ultrasonics Symposium, IUS · January 1, 2023 We verified the applicability of FBAR oscillators to local oscillators (LOs) in millimeter-wave communications (MMWc). Assuming the development of an oscillator chip that operates in the extra-high-frequency (EHF) band, which is a key component of an LO in ... Full text Cite

Higher-Order Allan Variance for Frequency Stability Evaluation of Multi-Dimensional Atomic Clocks

Journal Article IEEJ Transactions on Electronics, Information and Systems · January 1, 2023 In this paper, we analyze a generalized version of the Allan variance, referred to as a higher-order Allan variance, that can evaluate the frequency stability of multi-dimensional atomic clocks as a function of the measurement interval. It is known that th ... Full text Cite

Equivalence of JST Algorithm and Kalman Filtering Algorithm for Time Scale Generation

Conference IEEE International Symposium on Precision Clock Synchronization for Measurement, Control, and Communication, ISPCS · January 1, 2023 Existing studies have established two different algorithms, the Kalman filtering algorithm and the Japan Standard Time (JST) algorithm, for generating reliable time scales. However, the relations between those two methods have not been clarified. In this p ... Full text Cite

Spectral Decomposition in Kalman Filter Algorithm for Homogeneous Atomic Clock Ensembles

Conference Proceedings of the IEEE Conference on Decision and Control · January 1, 2023 Existing studies have pointed out numerical instability in the Kalman filter of atomic clocks, but the reasons for such instability have not been clarified mathematically. In this paper, we mathematically clarify the reason for the numerical instability by ... Full text Cite

Dose-dependent relationship of blood pressure and glycaemic status with risk of aortic dissection and aneurysm.

Journal Article Eur J Prev Cardiol · December 21, 2022 AIMS: Data on the dose-dependent association of blood pressure (BP) and fasting plasma glucose (FPG) level with the risk of aortic dissection (AD) and aortic aneurysm (AA) are limited. METHODS AND RESULTS: This observational cohort study included 3 358 293 ... Full text Link to item Cite

Glycemic status and the association of change in blood pressure with incident cardiovascular disease.

Journal Article Am Heart J · December 2022 BACKGROUND: The clinical benefit of blood pressure (BP) reduction in individuals with diabetes has not been fully elucidated. We sought to identify the clinical impact of BP reduction on incident cardiovascular disease in people having diabetes and hyperte ... Full text Link to item Cite

Cross-sectional association of equol producing status with aortic calcification in Japanese men aged 40-79 years.

Journal Article Sci Rep · November 22, 2022 Equol is an isoflavone (ISF)-derived metabolite by the gut microbiome in certain individuals termed equol-producers (EP). Equol might be the critical anti-atherogenic component of ISFs. In a population-based study of 979 Japanese men aged 40-79 without car ... Full text Link to item Cite

Alcohol consumption and subclinical and clinical coronary heart disease: a Mendelian randomization analysis.

Journal Article Eur J Prev Cardiol · November 8, 2022 AIMS: The potential effect of alcohol consumption on coronary heart disease (CHD) remains unclear. We used the variant rs671 in the aldehyde dehydrogenase 2 gene (ALDH2) as an instrument to investigate the causal role of alcohol intake in subclinical and c ... Full text Link to item Cite

Immune Checkpoint Inhibitors Do Not Increase Short-Term Risk of Hypertension in Cancer Patients: a Systematic Literature Review and Meta-Analysis.

Journal Article Hypertension · November 2022 BACKGROUND: Immune checkpoint inhibitors (ICIs) are becoming widely used for novel cancer treatments. Immune-related adverse events, including cardiac toxicity, are frequently observed following immune checkpoint inhibitor (ICI) use. However, little is kno ... Full text Link to item Cite

Effect of diabetes and prediabetes on the development of disability and mortality among middle-aged Japanese adults: A 22-year follow up of NIPPON DATA90.

Journal Article J Diabetes Investig · November 2022 AIMS/INTRODUCTION: To examine the association between diabetes and prediabetes at baseline, and disability, mortality over a 22-year period among middle-aged Japanese adults. MATERIALS AND METHODS: Participants consisted of 1,788 adults aged 45-64 years at ... Full text Link to item Cite

Reduction in blood pressure for elevated blood pressure/stage 1 hypertension according to the American College of Cardiology/American Heart Association guideline and cardiovascular outcomes.

Journal Article Eur J Prev Cardiol · October 20, 2022 AIMS: Few studies have examined the relationship of blood pressure (BP) change in adults with elevated BP or stage 1 hypertension according to the American College of Cardiology (ACC)/American Heart Association (AHA) guideline with cardiovascular outcomes. ... Full text Link to item Cite

Association of Cardiovascular Health Metrics With Risk of Transition to Hypertension in Non-Hypertensive Young Adults.

Journal Article Am J Hypertens · October 3, 2022 BACKGROUND: The risk of developing hypertension in young adults and its relationship to modifiable lifestyle factors are unclear. We aimed to examine the association of cardiovascular health (CVH) metrics with the risk of hypertension. METHODS: We analyzed ... Full text Link to item Cite

Association of achieved blood pressure after treatment for primary aldosteronism with long-term kidney function.

Journal Article J Hum Hypertens · October 2022 Little is known regarding the association of blood pressure (BP) after treatment for primary aldosteronism (PA) (i.e., adrenalectomy and mineralocorticoid receptor antagonists) with long-term renal outcomes, and whether the association is independent of BP ... Full text Link to item Cite

Incorporation of Retinal Arteriolosclerosis into Risk Stratification of Blood Pressure Category According to the 2017 ACC/AHA Blood Pressure Guideline.

Journal Article J Atheroscler Thromb · October 1, 2022 AIM: We investigated whether retinal arteriolosclerosis (RA) could be used for cardiovascular disease (CVD) risk stratification of individuals categorized according to the 2017 American College of Cardiology (ACC)/American Heart Association (AHA) Blood Pre ... Full text Link to item Cite

White-coat effect on orthostatic hypotension: a nationwide survey of Japanese general practitioners.

Journal Article Blood Press Monit · October 1, 2022 OBJECTIVE: The relationship between the white-coat effect (WCE), defined as white-coat hypertension under treatment, and the frequency of orthostatic hypotension (OH) is not known. We conducted an orthostatic test in patients with WCE to determine the freq ... Full text Link to item Cite

Antihypertensive Drugs and Cancer Risk.

Journal Article Am J Hypertens · September 1, 2022 Hypertension is the most prevalent comorbidity in cancer patients. Consequently, many cancer patients are prescribed antihypertensive drugs before cancer diagnosis or during cancer treatment. However, whether antihypertensive drugs affect the incidence, tr ... Full text Link to item Cite

The pattern of physical disability and determinants of activities of daily living among people with diabetes in Bangladesh.

Journal Article Endocrinol Diabetes Metab · September 2022 INTRODUCTION: Diabetes mellitus itself is a known predictor of physical disability and impairment in activities of daily living (ADL); however, there are existing controversies about the factors explaining the association between diabetes and disability. T ... Full text Link to item Cite

Threshold of Body Mass Index for the Development of Hypertension Among Japanese Adults.

Journal Article J Nutr · August 30, 2022 BACKGROUND: The optimal value of body mass index (BMI) for the development of hypertension and the influence of BMI on the development of stage 1 or stage 2 hypertension remain unclear. OBJECTIVES: We sought to identify the BMI threshold for the prevention ... Full text Link to item Cite

Semiquantitative assessed proteinuria and risk of heart failure: analysis of a nationwide epidemiological database.

Journal Article Nephrol Dial Transplant · August 22, 2022 BACKGROUND: Heart failure (HF) is increasing in prevalence worldwide. We explored whether adults with trace and positive proteinuria were at a high risk for incident HF compared with those with negative proteinuria using a nationwide epidemiological databa ... Full text Link to item Cite

Medication-Naïve Blood Pressure and Incident Cancers: Analysis of 2 Nationwide Population-Based Databases.

Journal Article Am J Hypertens · August 1, 2022 BACKGROUND: Results of preceding studies on the relationship between blood pressure (BP) and cancers have been confounded due to individuals taking antihypertensive medications or shared risk factors. We assessed whether medication-naïve high BP is a risk ... Full text Link to item Cite

Comparison of the association of masked hypertension defined by the 2017 ACC/AHA BP guideline versus the JNC7 guideline with left ventricular hypertrophy.

Journal Article J Hypertens · August 1, 2022 BACKGROUND: Compared with the Seventh Report of the Joint National Committee (JNC7), the 2017 American College of Cardiology/American Heart Association (ACC/AHA) blood pressure (BP) guideline uses lower BP thresholds to define hypertension and BP control. ... Full text Link to item Cite

Isolated Diastolic Hypertension and Risk of Cardiovascular Disease: Controversies in Hypertension - Pro Side of the Argument.

Journal Article Hypertension · August 2022 Isolated diastolic hypertension (IDH), defined as diastolic blood pressure in the hypertensive range but systolic blood pressure not in the hypertensive range, is not uncommon (<20%) among adults with hypertension. IDH often manifests in concurrence with o ... Full text Link to item Cite

Impact of Asleep and 24-Hour Blood Pressure Data on the Prevalence of Masked Hypertension by Race/Ethnicity.

Journal Article Am J Hypertens · July 1, 2022 BACKGROUND: We pooled ambulatory blood pressure monitoring data from 5 US studies, including the Jackson Heart Study (JHS), the Coronary Artery Risk Development in Young Adults (CARDIA) study, the Masked Hypertension Study, the Improving the Detection of H ... Full text Link to item Cite

Predicting Out-of-Office Blood Pressure in a Diverse US Population.

Journal Article Am J Hypertens · June 16, 2022 BACKGROUND: The PRedicting Out-of-OFfice Blood Pressure (PROOF-BP) algorithm accurately predicted out-of-office blood pressure (BP) among adults with suspected high BP in the United Kingdom and Canada. We tested the accuracy of PROOF-BP in a diverse US pop ... Full text Link to item Cite

Age-Dependent Relationship of Hypertension Subtypes With Incident Heart Failure.

Journal Article J Am Heart Assoc · May 3, 2022 Background The prevalence of hypertension subtypes changes with age. However, little is known regarding the age-dependent association of hypertension subtypes with incident heart failure (HF). Methods and Results We conducted an observational cohort study ... Full text Link to item Cite

Association between proteinuria and incident colorectal cancer: analysis of a nationwide population-based database.

Journal Article BMJ Open · April 4, 2022 OBJECTIVES: This study aimed to assess whether adults with proteinuria were at a higher risk of incident colorectal cancer (CRC) than those without proteinuria using a large-scale population-based database. DESIGN: A retrospective observational study. SETT ... Full text Link to item Cite

Blood Pressure Variability Early After Liver Transplantation Predicts Long-Term Mortality.

Journal Article Liver Transpl · April 2022 Cardiovascular disease is a leading cause of mortality after liver transplantation (LT). Elevated blood pressure (BP) in LT recipients (LTRs) is associated with increased cardiovascular events (CVEs) and decreased survival. Increased visit-to-visit BP vari ... Full text Link to item Cite

Risk for Proteinuria in Newly Defined Hypertensive People Based on the 2017 American College of Cardiology/American Heart Association Blood Pressure Guideline.

Journal Article Am J Cardiol · April 1, 2022 Whether blood pressure (BP) classification using the 2017 American College of Cardiology (ACC)/American Heart Association (AHA) BP guideline can identify patients at high risk for proteinuria remains unknown. We examined the association of BP classificatio ... Full text Link to item Cite

The associations of the national health and productivity management program with corporate profits in Japan.

Journal Article Epidemiol Health · 2022 OBJECTIVES: Using a dataset from a survey on national health and productivity management, we identified health and productivity factors associated with organizational profitability. METHODS: The Ministry of Economy, Trade and Industry conducted an annual s ... Full text Link to item Cite

FBAR Oscillator and MEMS Tunable VCSEL to Generate the Probe Lasers for Microfabricated Atomic Clock

Conference IEEE International Ultrasonics Symposium, IUS · January 1, 2022 In this paper, we describe several new approaches to cost reduction for the realization of ultraminiaturized atomic clocks. One is the development of a wavelength tuner for vertical-cavity surface-emitting lasers (VCSELs) for the atomic clocks. Our VCSEL i ... Full text Cite

Number and timing of ambulatory blood pressure monitoring measurements.

Journal Article Hypertens Res · December 2021 Ambulatory blood pressure (BP) monitoring (ABPM) may cause sleep disturbances. Some home BP monitoring (HBPM) devices obtain a limited number of BP readings during sleep and may be preferred to ABPM. It is unclear how closely a few BP readings approximate ... Full text Link to item Cite

Untreated Hypertension and Subsequent Incidence of Colorectal Cancer: Analysis of a Nationwide Epidemiological Database.

Journal Article J Am Heart Assoc · November 16, 2021 Background Studies of the association of hypertension with incident colorectal cancer (CRC) may have been confounded by including individuals taking antihypertensive medication, at high risk for CRC (ie, colorectal polyps and inflammatory bowel disease), o ... Full text Link to item Cite

Relation of the Metabolic Syndrome to Incident Colorectal Cancer in Young Adults Aged 20 to 49 Years.

Journal Article Am J Cardiol · November 1, 2021 Onco-cardiology is the emerging field, and the concept of shared risk factor holds an important position in this field. The increasing prevalence of colorectal cancer (CRC) in young adults is a critical epidemiological issue. Although metabolic syndrome, w ... Full text Link to item Cite

Kidney Outcomes Associated With SGLT2 Inhibitors Versus Other Glucose-Lowering Drugs in Real-world Clinical Practice: The Japan Chronic Kidney Disease Database.

Journal Article Diabetes Care · November 2021 OBJECTIVE: Randomized controlled trials have shown kidney-protective effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors, and clinical practice databases have suggested that these effects translate to clinical practice. However, long-term efficacy ... Full text Link to item Cite

Decision Tree-Based Classification for Maintaining Normal Blood Pressure Throughout Early Adulthood and Middle Age: Findings From the Coronary Artery Risk Development in Young Adults (CARDIA) Study.

Journal Article Am J Hypertens · October 27, 2021 BACKGROUND: For most individuals, blood pressure (BP) is related to multiple risk factors. By utilizing the decision tree analysis technique, this study aimed to identify the best discriminative risk factors and interactions that are associated with mainta ... Full text Link to item Cite

Association Between Blood Pressure Classification Using the 2017 ACC/AHA Blood Pressure Guideline and Retinal Atherosclerosis.

Journal Article American journal of hypertension · October 2021 BackgroundWe aimed to explore the association between the blood pressure (BP) classification defined by the 2017 American College of Cardiology (ACC)/American Heart Association (AHA) guideline and the prevalence of retinal atherosclerosis.Meth ... Full text Cite

Comparison of Brachial Blood Pressure and Central Blood Pressure in Attended, Unattended, and Unattended Standing Situations.

Journal Article Hypertens Res · October 2021 Central systolic blood pressure (cSBP) is an independent predictor of future cardiovascular disease. Unattended brachial SBP (bSBP) can eliminate the white-coat effect. However, unattended cSBP and unattended standing cSBP have never been reported. We aime ... Full text Link to item Cite

Relation of Serum Uric Acid and Cardiovascular Events in Young Adults Aged 20-49 Years.

Journal Article Am J Cardiol · August 1, 2021 Serum uric acid (SUA) was reported to be associated with incident cardiovascular disease (CVD). However, the relationship between SUA and CVD among young adults has not been clarified yet. In this study, we aimed to identify the association of medication n ... Full text Link to item Cite

Does This Adult Patient Have Hypertension?: The Rational Clinical Examination Systematic Review.

Journal Article JAMA · July 27, 2021 IMPORTANCE: Office blood pressure (BP) measurements are not the most accurate method to diagnose hypertension. Home BP monitoring (HBPM) and 24-hour ambulatory BP monitoring (ABPM) are out-of-office alternatives, and ABPM is considered the reference standa ... Full text Link to item Cite

Fasting Plasma Glucose and Incident Colorectal Cancer: Analysis of a Nationwide Epidemiological Database Fasting Plasma Glucose and Colorectal Cancer.

Journal Article J Clin Endocrinol Metab · June 25, 2021 CONTEXT: Although diabetes mellitus (DM) was reported to be associated with incident colorectal cancer (CRC), the detailed association between fasting plasma glucose (FPG) and incident CRC has not been fully understood. OBJECTIVE: We assessed whether hyper ... Full text Link to item Cite

Evaluation of New Solid Rubidium Source Using Atomic Clock Stabilization Loop

Conference 21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021 · June 20, 2021 We synthesized and evaluated rubidium azide as a new solid alkali metal source for microfabricated atomic clocks. A MEMS-based gas cell was filled with Rb as the alkali metal source for activation and a buffer gas (N2 or Ar), and the frequency stability wa ... Full text Cite

Association of Blood Pressure Classification Using the 2017 American College of Cardiology/American Heart Association Blood Pressure Guideline With Risk of Heart Failure and Atrial Fibrillation.

Journal Article Circulation · June 8, 2021 BACKGROUND: Heart failure (HF) and atrial fibrillation (AF) are growing in prevalence worldwide. Few studies have assessed to what extent stage 1 hypertension in the 2017 American College of Cardiology/American Heart Association blood pressure (BP) guideli ... Full text Link to item Cite

Reflection-type vapor cell for micro atomic clocks using local anodic bonding of 45° mirrors.

Journal Article Opt Lett · May 15, 2021 This Letter reports the design, fabrication, and evaluation of reflection-type planar vapor cells for chip-scale atomic clocks. The cell with 2-8 mm cavity length contains two 45° Bragg reflector mirrors assembled using a local anodic bonding. Coherent pop ... Full text Link to item Cite

Blood Pressure Levels in Young Adulthood and Midlife Stroke Incidence in a Diverse Cohort.

Journal Article Hypertension (Dallas, Tex. : 1979) · May 2021 [Figure: see text]. ... Full text Cite

Association of aldosterone and blood pressure with the risk for cardiovascular events after treatments in primary aldosteronism.

Journal Article Atherosclerosis · May 2021 Background and aimsWe used a dataset from a Japanese nationwide registry of patients with primary aldosteronism, to determine which of the parameters of hyperaldosteronism and blood pressure before or after treatments for primary aldosteronism (i. ... Full text Cite

Blood Pressure in Young Adults and Cardiovascular Disease Later in Life.

Journal Article Am J Hypertens · April 2, 2021 Cardiovascular disease (CVD) mortality has declined markedly over the past several decades among middle-age and older adults in the United States. However, young adults (18-39 years of age) have had a lower rate of decline in CVD mortality. This trend may ... Full text Link to item Cite

Gut Microbiome over a Lifetime and the Association with Hypertension.

Journal Article Curr Hypertens Rep · March 8, 2021 PURPOSE OF REVIEW: Microorganisms living within an ecosystem create microbial communities and play key roles in ecosystem functioning. During their lifespan, humans share their bodies with a variety of microorganisms. More than 10-100 trillion symbiotic mi ... Full text Link to item Cite

Early-but Not Late-Onset Hypertension Is Related to Midlife Cognitive Function.

Journal Article Hypertension · March 3, 2021 Hypertension is related to increased risk of cognitive decline in a highly age-dependent manner. However, conflicting evidence exists on the relation between age of hypertension onset and cognition. Our goal was to investigate the association between early ... Full text Link to item Cite

The Population-Attributable Fraction for Premature Mortality Due to Cardiovascular Disease Associated With Stage 1 and 2 Hypertension Among Japanese.

Journal Article Am J Hypertens · February 18, 2021 BACKGROUND: Our aim was to assess how the population-attributable fraction (PAF) for premature mortality due to cardiovascular disease (CVD) associated with hypertension changes if blood pressure (BP) thresholds for hypertension were lowered from systolic/ ... Full text Link to item Cite

Contribution of chemotherapy to improved prognosis in stage 4 gastric cancer: trend analysis of a regional population-based cancer registry in Japan.

Journal Article Int J Clin Oncol · February 2021 OBJECTIVES: Little is known about time trends in the prognosis of gastric cancer (GC), since the introduction of new chemotherapeutic agents. This study aimed to analyze how the increased number of available chemotherapeutic options affected the prognosis ... Full text Link to item Cite

Super-high-frequency-band injection-locked two-divider oscillator using thin-film bulk acoustic resonator

Journal Article Electronics Letters · February 1, 2021 An injection-locked divider oscillator that converts a 6-GHz-band signal into a 3-GHz-band signal was developed. The injection-locked divider oscillator was specifically designed to lock on the clock transition frequency of 87Rb of 6.824 GHz to provide a l ... Full text Cite

New Concept of Onco-Hypertension and Future Perspectives.

Journal Article Hypertension · January 2021 Owing to aging populations, the prevalence of hypertension and associated cardiovascular events has been increasing worldwide. The morbidity and mortality due to cancer have also been increasing with aging populations. Several small-molecule inhibitors hav ... Full text Link to item Cite

Kidney Function and Aortic Stiffness, Pulsatility, and Endothelial Function in African Americans: The Jackson Heart Study.

Journal Article Kidney Med · 2021 RATIONALE & OBJECTIVE: The relation of vascular stiffness, endothelial function, and kidney function is incompletely elucidated in African Americans. Our hypothesis was that increased vascular stiffness and endothelial dysfunction are associated with low e ... Full text Link to item Cite

Study of 3-GHz-band Thin-film Bulk Acoustic Resonator Oscillators for Microfabricated Atomic Clocks

Conference IEEE International Ultrasonics Symposium, IUS · January 1, 2021 Ultracompact and ultrastable clock chips are essential for beyond 5G/6G (b5G/6G) telecommunication systems, and we are studying 3-GHz-band thin-film bulk acoustic resonator (FBAR) oscillators for the development of such clock chips. Good frequency instabil ... Full text Cite

Nighttime Blood Pressure Phenotype and Cardiovascular Prognosis: Practitioner-Based Nationwide JAMP Study.

Journal Article Circulation · November 10, 2020 BACKGROUND: Ambulatory and home blood pressure (BP) monitoring parameters are better predictors of cardiovascular events than are office BP monitoring parameters, but there is a lack of robust data and little information on heart failure (HF) risk. The JAM ... Full text Link to item Cite

Association of Arterial Stiffness With Kidney Function Among Adults Without Chronic Kidney Disease.

Journal Article Am J Hypertens · November 3, 2020 BACKGROUND: Our aims were to assess whether arterial stiffness is associated with a higher risk for kidney dysfunction among persons without chronic kidney disease (CKD). METHODS: We analyzed data from the national health checkup system in Japan; for our a ... Full text Link to item Cite

Underutilization of Treatment for Black Adults With Apparent Treatment-Resistant Hypertension: JHS and the REGARDS Study.

Journal Article Hypertension · November 2020 Resistant hypertension, defined as blood pressure levels above goal while taking ≥3 classes of antihypertensive medication or ≥4 classes regardless of blood pressure level, is associated with increased cardiovascular disease risk. The 2018 American Heart A ... Full text Link to item Cite

Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.

Journal Article Lancet · October 17, 2020 BACKGROUND: Achieving universal health coverage (UHC) involves all people receiving the health services they need, of high quality, without experiencing financial hardship. Making progress towards UHC is a policy priority for both countries and global inst ... Full text Link to item Cite

Five insights from the Global Burden of Disease Study 2019.

Journal Article Lancet · October 17, 2020 The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 ... Full text Open Access Link to item Cite

Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019.

Journal Article Lancet · October 17, 2020 BACKGROUND: Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study ... Full text Link to item Cite

Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.

Journal Article Lancet · October 17, 2020 BACKGROUND: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries ... Full text Link to item Cite

Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.

Journal Article Lancet · October 17, 2020 BACKGROUND: Rigorous analysis of levels and trends in exposure to leading risk factors and quantification of their effect on human health are important to identify where public health is making progress and in which cases current efforts are inadequate. Th ... Full text Link to item Cite

The global burden of falls: global, regional and national estimates of morbidity and mortality from the Global Burden of Disease Study 2017.

Journal Article Inj Prev · October 2020 BACKGROUND: Falls can lead to severe health loss including death. Past research has shown that falls are an important cause of death and disability worldwide. The Global Burden of Disease Study 2017 (GBD 2017) provides a comprehensive assessment of morbidi ... Full text Link to item Cite

Blood pressure management in an ecosystem context.

Journal Article Hypertens Res · October 2020 The Hippocratic text On Airs, Waters, Places advises physicians to attend to all aspects of the environment-the seasons, the wind direction, and the soil and water quality, i.e., the ecosystem-when addressing people's health. Hippocrates emphasizes that th ... Full text Link to item Cite

Association of Obstructive Sleep Apnea With Nighttime Blood Pressure in African Americans: The Jackson Heart Study.

Journal Article American journal of hypertension · October 2020 BackgroundObstructive sleep apnea (OSA), nocturnal hypertension, and nondipping systolic blood pressure (BP) are each highly prevalent among African Americans. However, few data are available on the association between OSA and nighttime BP in this ... Full text Cite

Clinical Associations of Vascular Stiffness, Microvascular Dysfunction, and Prevalent Cardiovascular Disease in a Black Cohort: The Jackson Heart Study.

Journal Article J Am Heart Assoc · September 15, 2020 Background Measures of vascular dysfunction are related to adverse cardiovascular disease (CVD) outcomes in non-Hispanic, White populations; however, data from Black individuals are limited. We aimed to investigate the associations between novel hemodynami ... Full text Link to item Cite

FBAR-based frequency divider oscillator for lock-in amplifier free atomic stabilization loop

Conference IEEE International Ultrasonics Symposium, IUS · September 7, 2020 We developed an injection-locking-type frequency-2-divider oscillator using a thin-film bulk acoustic resonator (FBAR) to achieve the ultrastabilization of frequency using the coherent population trapping (CPT) resonance of the 87Rb atom. When receiving th ... Full text Cite

Association of Resting Heart Rate With Blood Pressure and Incident Hypertension Over 30 Years in Black and White Adults: The CARDIA Study.

Journal Article Hypertension · September 2020 Few studies have assessed the association of resting heart rate (RHR) through young adulthood with incident hypertension by middle age. We investigated the association between RHR measured over 30 years with incident hypertension in a cohort of young Black ... Full text Link to item Cite

Vascular α1-Adrenergic Receptor Responsiveness in Masked Hypertension.

Journal Article Am J Hypertens · August 4, 2020 BACKGROUND: Masked hypertension (nonhypertensive in the clinic setting but hypertensive outside the clinic during wakefulness) is characterized by increased blood pressure in response to physical and emotional stressors that activate the sympathetic nervou ... Full text Link to item Cite

Long-Term Blood Pressure Variability in Young Adulthood and Coronary Artery Calcium and Carotid Intima-Media Thickness in Midlife: The CARDIA Study.

Journal Article Hypertension · August 2020 Recent evidence links long-term (visit-to-visit) blood pressure (BP) variability to the risk of cardiovascular disease, independent of mean BP levels. Potential associations between long-term BP variability and cardiovascular disease risk may be reflected ... Full text Link to item Cite

Sex differences in cardiovascular risk factors before and after the development of type 2 diabetes and risk for incident cardiovascular disease.

Journal Article Diabetes Res Clin Pract · August 2020 AIMS: To assess sex differences in cardiovascular (CVD) risk factor changes before and after the development of type 2 diabetes, and, the association between incident diabetes with incident CVD in mid-life. METHODS: We included 4893 Coronary Artery Risk De ... Full text Link to item Cite

Associations Between Changes in Plasma Renin Activity and Aldosterone Concentrations and Changes in Kidney Function After Treatment for Primary Aldosteronism.

Journal Article Kidney Int Rep · August 2020 INTRODUCTION: Greater reduction in estimated glomerular filtration rate (eGFR) after specific treatment for primary aldosteronism (PA) reflects improvement in glomerular hyperfiltration associated with PA and leads to better patient outcomes. However, litt ... Full text Link to item Cite

Self-reported Age of Hypertension Onset and Hypertension-Mediated Organ Damage in Middle-Aged Individuals.

Journal Article Am J Hypertens · July 18, 2020 BACKGROUND: Objectively defined early onset hypertension, based on repeated blood pressure measurements, is a strong risk factor for cardiovascular disease (CVD). We aimed to assess if also self-reported hypertension onset age is associated with hypertensi ... Full text Link to item Cite

Association Between Blood Pressure and Later-Life Cognition Among Black and White Individuals.

Journal Article JAMA Neurol · July 1, 2020 IMPORTANCE: Black individuals are more likely than white individuals to develop dementia. Whether higher blood pressure (BP) levels in black individuals explain differences between black and white individuals in dementia risk is uncertain. OBJECTIVE: To de ... Full text Link to item Cite

Association Between Visit-to-Visit Blood Pressure Variability in Early Adulthood and Myocardial Structure and Function in Later Life.

Journal Article JAMA Cardiol · July 1, 2020 IMPORTANCE: Long-term blood pressure (BP) variability has emerged as a reproducible measure that is associated with heart failure independent of systemic BP. Visit-to-visit BP variability may be associated with the risk of heart failure early in the life c ... Full text Link to item Cite

Cardiovascular Risk of Isolated Systolic or Diastolic Hypertension in Young Adults.

Journal Article Circulation · June 2, 2020 BACKGROUND: Little is known regarding health outcomes associated with isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), or systolic and diastolic hypertension (SDH) among young adults with stage 1 hypertension, defined using the ... Full text Link to item Cite

The Prognosis of Hepatocellular Carcinoma Treated with Sorafenib in Combination with TACE.

Journal Article Asian Pac J Cancer Prev · June 1, 2020 OBJECTIVE: Sorafenib have been shown to be effective in the treatment of advanced HCC and has been standard therapy since its release in Japan in 2009 (Llovet et al., 2008; Cheng et al., 2009). However, due to a low response rate, more aggressive combinati ... Full text Link to item Cite

Sleep Characteristics and Measures of Glucose Metabolism in Blacks: The Jackson Heart Study.

Journal Article J Am Heart Assoc · May 5, 2020 Background Characterizing associations of sleep characteristics with blood-glucose-level factors among blacks may clarify the underlying mechanisms of impaired glucose metabolism and help identify treatment targets to prevent diabetes mellitus in blacks. M ... Full text Link to item Cite

Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017.

Journal Article Nat Med · May 2020 A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- ... Full text Open Access Link to item Cite

Long-term cumulative blood pressure in young adults and incident heart failure, coronary heart disease, stroke, and cardiovascular disease: The CARDIA study.

Journal Article Eur J Prev Cardiol · April 10, 2020 AIMS: Cumulative blood pressure (BP) is a measure that incorporates the severity and duration of BP exposure. The prognostic significance of cumulative BP in young adults for cardiovascular diseases (CVDs) in comparison to BP severity alone is, however, un ... Full text Link to item Cite

Association of Blood Pressure Patterns in Young Adulthood With Cardiovascular Disease and Mortality in Middle Age.

Journal Article JAMA Cardiol · April 1, 2020 IMPORTANCE: Determining blood pressure (BP) patterns in young adulthood that are associated with cardiovascular disease (CVD) events in later life may help to identify young adults who have an increased risk for CVD. OBJECTIVE: To determine whether the lon ... Full text Link to item Cite

Development of Predictive Equations for Nocturnal Hypertension and Nondipping Systolic Blood Pressure.

Journal Article J Am Heart Assoc · January 21, 2020 Background Nocturnal hypertension, defined by a mean asleep systolic blood pressure (SBP)/diastolic blood pressure (BP) ≥120/70 mm Hg, and nondipping SBP, defined by an awake-to-asleep decline in SBP <10%, are each associated with increased risk for cardio ... Full text Link to item Cite

Association Between Blood Pressure Variability and Cerebral Small-Vessel Disease: A Systematic Review and Meta-Analysis.

Journal Article J Am Heart Assoc · January 7, 2020 Background Research links blood pressure variability (BPV) with stroke; however, the association with cerebral small-vessel disease (CSVD) remains unclear. As BPV and mean blood pressure are interrelated, it remains uncertain whether BPV adds additional in ... Full text Link to item Cite

Injection Locking Type 1/2 Frequency Divider Employing Piezoelectric MEMS Resonator for Simplifying the Micro Atomic Clock System

Conference Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) · January 1, 2020 This paper is the first report on injection-locking-type frequency dividers incorporating a piezoelectric MEMS resonator. It gives us a new step toward the ultraminiaturizion of atomic clocks to the chip level. Our devices can divide the 6-GHz-band RF sign ... Full text Cite

Drift-free FBAR oscillator using an atomic-resonance-stabilization technique

Conference IEEE International Ultrasonics Symposium, IUS · October 1, 2019 We developed a thin-film bulk acoustic resonator oscillator (FBAR-OSC) with drift-free and excellent frequency stability. The FBAR-OSC outputted the 3.5 GHz band oscillation and successfully stabilized it employing the coherent population trapping (CPT) re ... Full text Cite

Association of Daytime and Nighttime Blood Pressure With Cardiovascular Disease Events Among African American Individuals.

Journal Article JAMA Cardiol · September 1, 2019 IMPORTANCE: Little is known regarding health outcomes associated with higher blood pressure (BP) levels measured outside the clinic among African American individuals. OBJECTIVE: To examine whether daytime and nighttime BP levels measured outside the clini ... Full text Link to item Cite

Fasting glucose variability in young adulthood and incident diabetes, cardiovascular disease and all-cause mortality.

Journal Article Diabetologia · August 2019 AIMS/HYPOTHESIS: The aim of this study was to determine whether long-term intra-individual variability in fasting glucose (FG) during young adulthood is associated with incident diabetes, cardiovascular disease (CVD) and mortality. METHODS: We included par ... Full text Link to item Cite

Proportion of US Adults Recommended Out-of-Clinic Blood Pressure Monitoring According to the 2017 Hypertension Clinical Practice Guidelines.

Journal Article Hypertension · August 2019 The 2017 Hypertension Clinical Practice Guidelines recommend out-of-clinic BP monitoring to screen for white coat and masked hypertension among adults not taking antihypertensive medication and white coat effect and masked uncontrolled hypertension among a ... Full text Link to item Cite

Health Behaviors, Nocturnal Hypertension, and Non-dipping Blood Pressure: The Coronary Artery Risk Development in Young Adults and Jackson Heart Study.

Journal Article Am J Hypertens · July 17, 2019 BACKGROUND: Several health behaviors have been associated with hypertension based on clinic blood pressure (BP). Data on the association of health behaviors with nocturnal hypertension and non-dipping systolic BP (SBP) are limited. METHODS: We analyzed dat ... Full text Link to item Cite

A reflection-type vapor cell using anisotropic etching of silicon for micro atomic clocks

Journal Article Applied Physics Express · July 1, 2019 This paper reports the design, fabrication and evaluation of a reflection-type optical Rb vapor cell for chip-scale micro atomic clocks. To reduce the physical package height, the reflection-type vapor cell is developed, in which optical components can be ... Full text Cite

Nighttime Blood Pressure Measured by Home Blood Pressure Monitoring as an Independent Predictor of Cardiovascular Events in General Practice.

Journal Article Hypertension · June 2019 We developed an innovative automated home blood pressure (BP) monitoring method that measures BP while asleep repeatedly over several days. Our aim was to assess the predictive ability of nighttime BP obtained using the home BP device for incident cardiova ... Full text Link to item Cite

A Reflection Type Vapor Cell Based on Local Anodic Bonding of 45° Mirrors for Micro Atomic Clocks

Conference 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII · June 1, 2019 This paper reports the design, fabrication and evaluation of a reflection-type micro Rb vapor cell fabricated by local anodic bonding of small 45° mirrors. The 45° mirrors with a Bragg reflector are fabricated by using dicing process. The vapor cells havin ... Full text Cite

Estimating the association between blood pressure variability and cardiovascular disease: An application using the ARIC Study.

Journal Article Stat Med · May 10, 2019 The association between visit-to-visit systolic blood pressure variability and cardiovascular events has recently received a lot of attention in the cardiovascular literature. But, blood pressure variability is usually estimated on a person-by-person basis ... Full text Link to item Cite

Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

Journal Article Lancet Neurol · May 2019 BACKGROUND: Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive ... Full text Open Access Link to item Cite

Usefulness of Blood Pressure Variability Indices Derived From 24-Hour Ambulatory Blood Pressure Monitoring in Detecting Autonomic Failure.

Journal Article J Am Heart Assoc · April 2, 2019 Background Increased blood pressure ( BP ) variability and nondipping status seen on 24-hour ambulatory BP monitoring are often observed in autonomic failure ( ATF ). Methods and Results We assessed BP variability and nocturnal BP dipping in 273 patients u ... Full text Link to item Cite

Association Between Sleep Apnea and Blood Pressure Control Among Blacks.

Journal Article Circulation · March 5, 2019 BACKGROUND: Blacks have a high prevalence of hypertension and uncontrolled blood pressure (BP), each of which may be partially explained by untreated sleep apnea. We investigated the association of sleep apnea with uncontrolled BP and resistant hypertensio ... Full text Link to item Cite

Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium.

Journal Article Am J Kidney Dis · February 2019 RATIONALE & OBJECTIVE: Chronic kidney disease (CKD) is complicated by abnormalities that reflect disruption in filtration, tubular, and endocrine functions of the kidney. Our aim was to explore the relationship of specific laboratory result abnormalities a ... Full text Link to item Cite

Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

Journal Article Lancet Neurol · January 2019 BACKGROUND: The number of individuals living with dementia is increasing, negatively affecting families, communities, and health-care systems around the world. A successful response to these challenges requires an accurate understanding of the dementia dis ... Full text Link to item Cite

Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

Journal Article Lancet Neurol · January 2019 BACKGROUND: Traumatic brain injury (TBI) and spinal cord injury (SCI) are increasingly recognised as global health priorities in view of the preventability of most injuries and the complex and expensive medical care they necessitate. We aimed to measure th ... Full text Link to item Cite

Fast numerical analysis of the time response in coherent population trapping resonance based on Galerkin spectral method

Journal Article Japanese Journal of Applied Physics · January 1, 2019 We propose a new algorithm to calculate the time response of coherent population trapping (CPT) resonance. The Galerkin method using a Fourier series as a basis function (Galerkin spectral method) is widely employed for the numerical analysis of piezoelect ... Full text Cite

A Reflection-Type Vapor Cell for Micro Atomic Clock

Conference Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) · January 1, 2019 This paper reports the design, fabrication and evaluation of a reflection-type Rb vapor cell with a Glass/Si/Glass structure for chip-scale micro atomic clocks. To miniaturize the cell and obtain a Rb resonance signal with a high sensitivity, long laser li ... Full text Cite

Study of Quantitative Calculation of CPT Resonances Considering Zeeman Sub-Levels of CS-D1 Line

Conference IFCS 2018 - IEEE International Frequency Control Symposium · December 31, 2018 We developed a simulator that calculates the CPT resonances of all the energy levels of the Cs-Di line. The simulator can analyze the CPT resonances of not only the clock transition but also all the Zeeman sub-levels. To verify this calculation result, we ... Full text Cite

Global, Regional, and Country-Specific Lifetime Risks of Stroke, 1990 and 2016.

Journal Article N Engl J Med · December 20, 2018 BACKGROUND: The lifetime risk of stroke has been calculated in a limited number of selected populations. We sought to estimate the lifetime risk of stroke at the regional, country, and global level using data from a comprehensive study of the prevalence of ... Full text Link to item Cite

Fasting Glucose Variability in Young Adulthood and Cognitive Function in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.

Journal Article Diabetes Care · December 2018 OBJECTIVE: To determine whether intraindividual variability in fasting glucose (FG) below the threshold of diabetes is associated with cognitive function in middle adulthood beyond increasing FG. RESEARCH DESIGN AND METHODS: We studied 3,307 CARDIA (Corona ... Full text Link to item Cite

Diagnostic Thresholds for Blood Pressure Measured at Home in the Context of the 2017 Hypertension Guideline.

Journal Article Hypertension · December 2018 Most guidelines have recommended lower home blood pressure (BP) threshold when clinic BP threshold of 140/90 mm Hg is used for diagnosis of hypertension. However, home BP thresholds to define hypertension have never been determined in the general populatio ... Full text Link to item Cite

Erratum: Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017 (The Lancet (2018) 392(10159) (1736–1788)(S0140673618322037)(10.1016/S0140-6736(18)32203-7))

Journal Article The Lancet · November 17, 2018 GBD 2017 Causes of Death Collaborators. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018; 392: 1736 ... Full text Cite

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

Journal Article Lancet · November 10, 2018 BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk-outcome ... Full text Open Access Link to item Cite

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

Journal Article Lancet · November 10, 2018 BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries and territories from 1990 to 20 ... Full text Open Access Link to item Cite

Global, regional, and national age-sex-specific mortality and life expectancy, 1950-2017: a systematic analysis for the Global Burden of Disease Study 2017.

Journal Article Lancet · November 10, 2018 BACKGROUND: Assessments of age-specific mortality and life expectancy have been done by the UN Population Division, Department of Economics and Social Affairs (UNPOP), the United States Census Bureau, WHO, and as part of previous iterations of the Global B ... Full text Open Access Link to item Cite

Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017.

Journal Article Lancet · November 10, 2018 BACKGROUND: Global development goals increasingly rely on country-specific estimates for benchmarking a nation's progress. To meet this need, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 estimated global, regional, national, a ... Full text Link to item Cite

Population and fertility by age and sex for 195 countries and territories, 1950-2017: a systematic analysis for the Global Burden of Disease Study 2017.

Journal Article Lancet · November 10, 2018 BACKGROUND: Population estimates underpin demographic and epidemiological research and are used to track progress on numerous international indicators of health and development. To date, internationally available estimates of population and fertility, alth ... Full text Open Access Link to item Cite

Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017.

Journal Article Lancet · November 10, 2018 BACKGROUND: Efforts to establish the 2015 baseline and monitor early implementation of the UN Sustainable Development Goals (SDGs) highlight both great potential for and threats to improving health by 2030. To fully deliver on the SDG aim of "leaving no on ... Full text Open Access Link to item Cite

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

Journal Article Lancet · November 10, 2018 BACKGROUND: How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We c ... Full text Open Access Link to item Cite

Association of Blood Pressure Classification in Young Adults Using the 2017 American College of Cardiology/American Heart Association Blood Pressure Guideline With Cardiovascular Events Later in Life.

Journal Article JAMA · November 6, 2018 IMPORTANCE: Little is known regarding the association between level of blood pressure (BP) in young adulthood and cardiovascular disease (CVD) events by middle age. OBJECTIVE: To assess whether young adults who developed hypertension, defined by the 2017 A ... Full text Link to item Cite

Diagnosing Masked Hypertension Using Ambulatory Blood Pressure Monitoring, Home Blood Pressure Monitoring, or Both?

Journal Article Hypertension · November 2018 Guidelines recommend measuring out-of-clinic blood pressure (BP) to identify masked hypertension (MHT) defined by out-of-clinic BP in the hypertensive range among individuals with clinic-measured BP not in the hypertensive range. The aim of this study was ... Full text Link to item Cite

Microwave oscillator using piezoelectric thin-film resonator aiming for ultraminiaturization of atomic clock.

Journal Article Rev Sci Instrum · October 2018 We developed a microwave oscillator and a micro electromechanical systems-based rubidium cell for the miniaturization of atomic clocks. A thin-film bulk acoustic resonator (FBAR) having a resonant frequency of the fundamental mode in the 3.5 GHz band was e ... Full text Link to item Cite

Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

Journal Article Lancet · September 22, 2018 BACKGROUND: Alcohol use is a leading risk factor for death and disability, but its overall association with health remains complex given the possible protective effects of moderate alcohol consumption on some conditions. With our comprehensive approach to ... Full text Link to item Cite

Long-Term Blood Pressure Level and Variability From Midlife to Later Life and Subsequent Cognitive Change: The ARIC Neurocognitive Study.

Journal Article J Am Heart Assoc · August 7, 2018 Background To understand how blood pressure ( BP ) from midlife and beyond is related to cognition in older age, a lifespan approach is needed. We assessed the associations of BP levels and variability from midlife on with subsequent cognitive change. Meth ... Full text Link to item Cite

Association Between Change in Central Nocturnal Blood Pressure and Urine Albumin-Creatinine Ratio by a Valsartan/Amlodipine Combination: A CPET Study.

Journal Article Am J Hypertens · August 3, 2018 BACKGROUND: We aimed to assess the association of changes in brachial or central nocturnal systolic blood pressure (SBP) with change in urine albumin-creatinine ratio (UACR) by a valsartan/amlodipine combination (80/5 mg) therapy in hypertensive patients. ... Full text Link to item Cite

Peak lung function during young adulthood and future long-term blood pressure variability: The Coronary Artery Risk Development in Young Adults (CARDIA) study.

Journal Article Atherosclerosis · August 2018 BACKGROUND AND AIMS: Long-term blood pressure variability (BPV) is associated with cardiovascular events independent of mean blood pressure (BP); however, little is known about its predictors. METHODS: Using data from the CARDIA study, we investigated the ... Full text Link to item Cite

The importance of using 24-hour and nighttime blood pressure for the identification of white coat hypertension: Data from the Jackson Heart Study

Journal Article Journal of Clinical Hypertension · August 1, 2018 We calculated the prevalence of white coat hypertension (WCH) using out-of-clinic blood pressure (BP) in the daytime period; daytime and 24-hour periods; and daytime, 24-hour, and nighttime periods among 199 African Americans with clinic-measured systolic/ ... Full text Cite

Association of Cardiovascular Outcomes With Masked Hypertension Defined by Home Blood Pressure Monitoring in a Japanese General Practice Population.

Journal Article JAMA Cardiol · July 1, 2018 IMPORTANCE: The clinical outcomes associated with masked hypertension defined by home blood pressure monitoring (HBPM) in clinical settings remain uncertain. OBJECTIVE: To assess the association between masked hypertension and cardiovascular disease events ... Full text Link to item Cite

Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: a systematic analysis from the Global Burden of Disease Study 2016.

Journal Article Lancet · June 2, 2018 BACKGROUND: A key component of achieving universal health coverage is ensuring that all populations have access to quality health care. Examining where gains have occurred or progress has faltered across and within countries is crucial to guiding decisions ... Full text Link to item Cite

West African Ancestry and Nocturnal Blood Pressure in African Americans: The Jackson Heart Study.

Journal Article Am J Hypertens · May 7, 2018 BACKGROUND: African Americans have a higher prevalence of nocturnal hypertension and nondipping blood pressure than European Americans, but the genetic contribution to these racial differences remains unclear. We assessed the association of the percentage ... Full text Link to item Cite

The Burden of Cardiovascular Diseases Among US States, 1990-2016.

Journal Article JAMA Cardiol · May 1, 2018 IMPORTANCE: Cardiovascular disease (CVD) is the leading cause of death in the United States, but regional variation within the United States is large. Comparable and consistent state-level measures of total CVD burden and risk factors have not been produce ... Full text Link to item Cite

Adolescent health in the Eastern Mediterranean Region: findings from the global burden of disease 2015 study.

Journal Article Int J Public Health · May 2018 OBJECTIVES: The 22 countries of the East Mediterranean Region (EMR) have large populations of adolescents aged 10-24 years. These adolescents are central to assuring the health, development, and peace of this region. We described their health needs. METHOD ... Full text Link to item Cite

Diabetes mellitus and chronic kidney disease in the Eastern Mediterranean Region: findings from the Global Burden of Disease 2015 study.

Journal Article Int J Public Health · May 2018 OBJECTIVES: We used findings from the Global Burden of Disease 2015 study to update our previous publication on the burden of diabetes and chronic kidney disease due to diabetes (CKD-DM) during 1990-2015. METHODS: We extracted GBD 2015 estimates for preval ... Full text Link to item Cite

Micro atomic frequency standards employing an integrated FBAR-VCO oscillating on the 87RB clock frequency without a phase locked loop

Conference Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) · April 24, 2018 We applied a 3.5-GHz-band thin film bulk acoustic resonator (FBAR) to a voltage controlled oscillator (VCO), which is designed as a local oscillator of miniaturized atomic frequency standards (AFSs). This frequency reference instead of a bulky quartz reson ... Full text Cite

The State of US Health, 1990-2016: Burden of Diseases, Injuries, and Risk Factors Among US States.

Journal Article JAMA · April 10, 2018 INTRODUCTION: Several studies have measured health outcomes in the United States, but none have provided a comprehensive assessment of patterns of health by state. OBJECTIVE: To use the results of the Global Burden of Disease Study (GBD) to report trends i ... Full text Link to item Cite

Efficacy of direct-acting antiviral treatment for chronic hepatitis C: A single hospital experience

Journal Article World Journal of Hepatology · January 27, 2018 AIM To evaluate the efficacy of direct-acting antivirals (DAAs) in Kanto Rosai Hospital. METHODS All patients with hepatitis C virus (HCV) who underwent DAA prescription were enrolled in this study. The present study was a single center retrospective analy ... Full text Cite

Day-by-Day Variability of Home Blood Pressure and Incident Cardiovascular Disease in Clinical Practice: The J-HOP Study (Japan Morning Surge-Home Blood Pressure).

Journal Article Hypertension · January 2018 We assessed the relationship between day-by-day home blood pressure (BP) variability and incident cardiovascular disease (CVD) in clinical practice. J-HOP study (Japan Morning Surge-Home Blood Pressure) participants underwent home BP monitoring in the morn ... Full text Link to item Cite

FBAR Oscillator Stabilized by Rb Atomic Resonator for SHF/EHF-Band Wireless Devices

Conference IEEE International Ultrasonics Symposium, IUS · January 1, 2018 We propose an FBAR oscillator for the wireless system used in the superhigh-frequency (SHF) band or extremely high-frequency (EHF) band. At these frequencies, a high-precision standard clock is required, and it is preferable that the clock frequency be set ... Full text Cite

Visit-to-Visit Blood Pressure Variability in Young Adulthood and Hippocampal Volume and Integrity at Middle Age: The CARDIA Study (Coronary Artery Risk Development in Young Adults).

Journal Article Hypertension · December 2017 The aims of this study are to assess the relationships of visit-to-visit blood pressure (BP) variability in young adulthood to hippocampal volume and integrity at middle age. We used data over 8 examinations spanning 25 years collected in the CARDIA study ... Full text Link to item Cite

Comparison of morning vs bedtime administration of the combination of valsartan/amlodipine on nocturnal brachial and central blood pressure in patients with hypertension.

Journal Article J Clin Hypertens (Greenwich) · December 2017 The aim of this study was to compare the effect of morning and bedtime administration of valsartan/amlodipine combination therapy (80/5 mg) on nocturnal brachial and central blood pressure (BP) measured by ambulatory BP monitoring in patients with hyperten ... Full text Link to item Cite

Coherent population trapping atomic clock by phase modulation for wide locking range

Journal Article Applied Physics Letters · November 13, 2017 A method of detecting Coherent Population Trapping resonance by phase modulation (PM) was studied to expand the frequency locking range (LR). We calculated error signals by density matrix analysis using an eigenvector algorithm and verified the calculated ... Full text Cite

"Time rate" of 24-hour blood pressure variability.

Journal Article J Clin Hypertens (Greenwich) · November 2017 Full text Link to item Cite

Global, regional, and national burden of neurological disorders during 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

Journal Article Lancet Neurol · November 2017 BACKGROUND: Comparable data on the global and country-specific burden of neurological disorders and their trends are crucial for health-care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study provides su ... Full text Link to item Cite

Department of Error.

Journal Article Lancet · October 28, 2017 Full text Link to item Cite

Associations of Nocturnal Blood Pressure With Cognition by Self-Identified Race in Middle-Aged and Older Adults: The GENOA (Genetic Epidemiology Network of Arteriopathy) Study.

Journal Article J Am Heart Assoc · October 27, 2017 BACKGROUND: Whether the association of blood pressure (BP) during sleep (nocturnal BP) with cognition differs by race is unknown. METHODS AND RESULTS: Participants in the GENOA (Genetic Epidemiology Network of Arteriopathy) Study underwent ambulatory BP me ... Full text Link to item Cite

Theoretical and experimental study of Rb coherent population trapping atomic clock with phase modulation detection

Conference 2017 Joint Conference of the European Frequency and Time Forum and IEEE International Frequency Control Symposium, EFTF/IFC 2017 - Proceedings · October 27, 2017 We theoretically and experimentally study Coherent Population Trapping (CPT) resonance with phase modulation detection. We measured the time response behavior of CPT resonance using an 87Rb gas cell and the D1-line vertical-cavity surface-emitting laser(VC ... Full text Cite

Department of Error.

Journal Article Lancet · September 30, 2017 Full text Link to item Cite

The Effect of New Therapeutic and Diagnostic Agents on the Prognosis of Hepatocellular Carcinoma in Japan – An Analysis of Data from the Kanagawa Cancer Registry.

Journal Article Asian Pac J Cancer Prev · September 27, 2017 Objective: Notable advances in diagnostic imaging modalities and therapeutic agents have contributed to improvement in the prognosis of hepatocellular carcinoma (HCC) over the past decade. However, knowledge concerning their epidemiological contribution re ... Full text Link to item Cite

Masked Hypertension.

Journal Article Curr Hypertens Rep · September 19, 2017 Full text Link to item Cite

Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for the Global Burden of Disease Study 2016.

Journal Article Lancet · September 16, 2017 BACKGROUND: Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause mortality has changed with respe ... Full text Link to item Cite

Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

Journal Article Lancet · September 16, 2017 BACKGROUND: Measurement of changes in health across locations is useful to compare and contrast changing epidemiological patterns against health system performance and identify specific needs for resource allocation in research, policy development, and pro ... Full text Link to item Cite

Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

Journal Article Lancet · September 16, 2017 BACKGROUND: As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors S ... Full text Link to item Cite

Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016.

Journal Article Lancet · September 16, 2017 BACKGROUND: The UN's Sustainable Development Goals (SDGs) are grounded in the global ambition of "leaving no one behind". Understanding today's gains and gaps for the health-related SDGs is essential for decision makers as they aim to improve the health of ... Full text Link to item Cite

Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016.

Journal Article Lancet · September 16, 2017 BACKGROUND: Monitoring levels and trends in premature mortality is crucial to understanding how societies can address prominent sources of early death. The Global Burden of Disease 2016 Study (GBD 2016) provides a comprehensive assessment of cause-specific ... Full text Link to item Cite

Association of Coronary Artery Calcium Score vs Age With Cardiovascular Risk in Older Adults: An Analysis of Pooled Population-Based Studies.

Journal Article JAMA Cardiol · September 1, 2017 IMPORTANCE: Besides age, other discriminators of atherosclerotic cardiovascular disease (ASCVD) risk are needed in older adults. OBJECTIVES: To examine the predictive ability of coronary artery calcium (CAC) score vs age for incident ASCVD and how risk pre ... Full text Link to item Cite

Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

Journal Article Lancet Respir Med · September 2017 BACKGROUND: Chronic obstructive pulmonary disease (COPD) and asthma are common diseases with a heterogeneous distribution worldwide. Here, we present methods and disease and risk estimates for COPD and asthma from the Global Burden of Diseases, Injuries, a ... Full text Link to item Cite

Primary Hepatic Lymphoma Complicated by a Hepatic Inflammatory Pseudotumor and Tumor-Forming Pancreatitis.

Journal Article J Gastrointestin Liver Dis · September 2017 BACKGROUND: Hepatic inflammatory pseudotumor (IPT) is considered to be benign in biological behavior, and its malignant transformation is extremely rare. There has only been one published case of primary hepatic lymphoma complicated by hepatic IPT. CASE PR ... Full text Link to item Cite

Cardiovascular health in young adulthood and structural brain MRI in midlife: The CARDIA study.

Journal Article Neurology · August 15, 2017 OBJECTIVE: To examine the association between the American Heart Association (AHA) Life's Simple 7 (LS7) metric and brain structure. METHODS: We determined cardiovascular health (CVH) according to the AHA LS7, assigning 0, 1, or 2 points for meeting poor, ... Full text Link to item Cite

Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: a novel analysis from the Global Burden of Disease Study 2015.

Journal Article Lancet · July 15, 2017 BACKGROUND: National levels of personal health-care access and quality can be approximated by measuring mortality rates from causes that should not be fatal in the presence of effective medical care (ie, amenable mortality). Previous analyses of mortality ... Full text Link to item Cite

Health Effects of Overweight and Obesity in 195 Countries over 25 Years.

Journal Article N Engl J Med · July 6, 2017 BACKGROUND: Although the rising pandemic of obesity has received major attention in many countries, the effects of this attention on trends and the disease burden of obesity remain uncertain. METHODS: We analyzed data from 68.5 million persons to assess th ... Full text Link to item Cite

Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015.

Journal Article J Am Coll Cardiol · July 4, 2017 BACKGROUND: The burden of cardiovascular diseases (CVDs) remains unclear in many regions of the world. OBJECTIVES: The GBD (Global Burden of Disease) 2015 study integrated data on disease incidence, prevalence, and mortality to produce consistent, up-to-da ... Full text Link to item Cite

Global Cardiovascular and Renal Outcomes of Reduced GFR.

Journal Article J Am Soc Nephrol · July 2017 The burden of premature death and health loss from ESRD is well described. Less is known regarding the burden of cardiovascular disease attributable to reduced GFR. We estimated the prevalence of reduced GFR categories 3, 4, and 5 (not on RRT) for 188 coun ... Full text Link to item Cite

Hemodynamic and Mechanical Properties of the Proximal Aorta in Young and Middle-Aged Adults With Isolated Systolic Hypertension: The Dallas Heart Study.

Journal Article Hypertension · July 2017 The aim of this study was to assess characteristic impedance (Zc) of the proximal aorta in young and middle-aged individuals with isolated systolic hypertension (ISH). Zc is an index of aortic stiffness relative to aortic size. In the Dallas Heart Study, 2 ... Full text Link to item Cite

Clinical Perspective on Antihypertensive Drug Treatment in Adults With Grade 1 Hypertension and Low-to-Moderate Cardiovascular Risk: An International Expert Consultation.

Journal Article Curr Probl Cardiol · July 2017 Hypertension is a leading risk factor for disease burden globally. An unresolved question is whether grade 1 hypertension (140-159/90-99mmHg) with low (cardiovascular mortality <1% at 10 years) to moderate (cardiovascular mortality ≥1% and <5% at 10 years) ... Full text Link to item Cite

Child and Adolescent Health From 1990 to 2015: Findings From the Global Burden of Diseases, Injuries, and Risk Factors 2015 Study.

Journal Article JAMA Pediatr · June 1, 2017 IMPORTANCE: Comprehensive and timely monitoring of disease burden in all age groups, including children and adolescents, is essential for improving population health. OBJECTIVE: To quantify and describe levels and trends of mortality and nonfatal health ou ... Full text Link to item Cite

Smoking prevalence and attributable disease burden in 195 countries and territories, 1990-2015: a systematic analysis from the Global Burden of Disease Study 2015.

Journal Article Lancet · May 13, 2017 BACKGROUND: The scale-up of tobacco control, especially after the adoption of the Framework Convention for Tobacco Control, is a major public health success story. Nonetheless, smoking remains a leading risk for early death and disability worldwide, and th ... Full text Link to item Cite

Racial Differences in Associations of Blood Pressure Components in Young Adulthood With Incident Cardiovascular Disease by Middle Age: Coronary Artery Risk Development in Young Adults (CARDIA) Study.

Journal Article JAMA Cardiol · April 1, 2017 IMPORTANCE: Data are sparse regarding which blood pressure (BP) components in young adulthood optimally determine cardiovascular disease (CVD) by middle age. OBJECTIVES: To assess which BP components best determine incident CVD events in young adults and d ... Full text Link to item Cite

Two-step pulse observation to improve resonance contrast for coherent population trapping atomic clock

Journal Article Applied Physics B: Lasers and Optics · March 1, 2017 We study resonance contrast by a two-step pulse observation method to enhance the frequency stability of coherent population trapping (CPT) atomic clocks. The proposed method is a two-step Raman–Ramsey scheme with low intensity during resonance observation ... Full text Cite

On-Treatment Blood Pressure and Cardiovascular Outcomes in Older Adults With Isolated Systolic Hypertension.

Journal Article Hypertension · February 2017 UNLABELLED: Our aim was to assess optimal on-treatment blood pressure (BP) at which cardiovascular disease (CVD) and all-cause mortality risks are minimized in Japanese older adults with isolated systolic hypertension. We used data from the VALISH study (V ... Full text Link to item Cite

Global Burden of Hypertension and Systolic Blood Pressure of at Least 110 to 115 mm Hg, 1990-2015.

Journal Article JAMA · January 10, 2017 IMPORTANCE: Elevated systolic blood (SBP) pressure is a leading global health risk. Quantifying the levels of SBP is important to guide prevention policies and interventions. OBJECTIVE: To estimate the association between SBP of at least 110 to 115 mm Hg a ... Full text Link to item Cite

Association Between Long-Term Blood Pressure Variability and 10-Year Progression in Arterial Stiffness: The Multiethnic Study of Atherosclerosis.

Journal Article Hypertension · January 2017 Experimental studies conducted on animal and human endothelium suggested that higher systolic blood pressure (SBP) variability reduces bioavailability of nitric oxide and increases vascular smooth muscle cell proliferation. These vascular wall changes coul ... Full text Link to item Cite

Salt and Blood Pressure

Chapter · January 1, 2017 Humans have had a long, close, and complex relationship with salt. Salt (sodium chloride) is essential for life. However, excess salt intake may be hazardous to our health. This section provides an overview of the current understanding of the relationship ... Full text Cite

Isolated Systolic Hypertension in Young and Middle-Aged Adults.

Journal Article Curr Hypertens Rep · November 2016 Young and middle-aged adults (ages ≤50 years) are increasingly prone to stroke, kidney disease, and worsening cardiovascular disease (CVD) mortality. An alarming increase in the prevalence of high blood pressure (BP) may underlie the adverse trend. However ... Full text Link to item Cite

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015.

Journal Article Lancet · October 8, 2016 BACKGROUND: Improving survival and extending the longevity of life for all populations requires timely, robust evidence on local mortality levels and trends. The Global Burden of Disease 2015 Study (GBD 2015) provides a comprehensive assessment of all-caus ... Full text Link to item Cite

Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

Journal Article Lancet · October 8, 2016 BACKGROUND: Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measures of health across geographies and time that can inform assessments of epidemiological patterns and health system performance, help to prioritise i ... Full text Link to item Cite

Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

Journal Article Lancet · October 8, 2016 BACKGROUND: Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to ... Full text Link to item Cite

Measuring the health-related Sustainable Development Goals in 188 countries: a baseline analysis from the Global Burden of Disease Study 2015.

Journal Article Lancet · October 8, 2016 BACKGROUND: In September, 2015, the UN General Assembly established the Sustainable Development Goals (SDGs). The SDGs specify 17 universal goals, 169 targets, and 230 indicators leading up to 2030. We provide an analysis of 33 health-related SDG indicator ... Full text Link to item Cite

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

Journal Article Lancet · October 8, 2016 BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning th ... Full text Link to item Cite

Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015.

Journal Article Lancet · October 8, 2016 BACKGROUND: Established in 2000, Millennium Development Goal 4 (MDG4) catalysed extraordinary political, financial, and social commitments to reduce under-5 mortality by two-thirds between 1990 and 2015. At the country level, the pace of progress in improv ... Full text Link to item Cite

Global, regional, and national levels of maternal mortality, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

Journal Article Lancet · October 8, 2016 BACKGROUND: In transitioning from the Millennium Development Goal to the Sustainable Development Goal era, it is imperative to comprehensively assess progress toward reducing maternal mortality to identify areas of success, remaining challenges, and frame ... Full text Link to item Cite

Erratum: Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980-2015: The Global Burden of Disease Study 2015 (The Lancet HIV (2016) 3 (e361-e387) PII: S235230181630087X DOI: 10.1016/S2352-3018(16)30087-X)

Journal Article The Lancet HIV · September 1, 2016 GBD 2015 HIV Collaborators. Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2015: the Global Burden of Disease Study 2015. Lancet HIV 2016; 3: e361–87—In this Article, Kerrie E Doyle and David M Pereira have be ... Full text Cite

Regional Fat Distribution and Blood Pressure Level and Variability: The Dallas Heart Study.

Journal Article Hypertension · September 2016 Our aim was to investigate the associations of regional fat distribution with home and office blood pressure (BP) levels and variability. Participants in the Dallas Heart Study, a multiethnic cohort, underwent 5 BP measurements on 3 occasions during 5 mont ... Full text Link to item Cite

Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980-2015: the Global Burden of Disease Study 2015.

Journal Article Lancet HIV · August 2016 BACKGROUND: Timely assessment of the burden of HIV/AIDS is essential for policy setting and programme evaluation. In this report from the Global Burden of Disease Study 2015 (GBD 2015), we provide national estimates of levels and trends of HIV/AIDS inciden ... Full text Link to item Cite

Morning and Evening Home Blood Pressure and Risks of Incident Stroke and Coronary Artery Disease in the Japanese General Practice Population: The Japan Morning Surge-Home Blood Pressure Study.

Journal Article Hypertension · July 2016 UNLABELLED: Our aim is to determine the optimal time schedule for home blood pressure (BP) monitoring that best predicts stroke and coronary artery disease in general practice. The Japan Morning Surge-Home Blood Pressure (J-HOP) study is a nationwide pract ... Full text Link to item Cite

Associations of cortisol/testosterone and cortisol/sex hormone-binding globulin ratios with atherosclerosis in middle-age women.

Journal Article Atherosclerosis · May 2016 BACKGROUND AND AIMS: The cortisol/testosterone (C/T) ratio has been hypothesized to be a better predictor of atherosclerosis than cortisol alone. No study has assessed whether the C/T and C/sex hormone-binding globulin (SHBG) ratios are associated with ath ... Full text Link to item Cite

Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013: Findings From the Global Burden of Disease 2013 Study.

Journal Article JAMA Pediatr · March 2016 IMPORTANCE: The literature focuses on mortality among children younger than 5 years. Comparable information on nonfatal health outcomes among these children and the fatal and nonfatal burden of diseases and injuries among older children and adolescents is ... Full text Link to item Cite

Blood Pressure Reactivity to Psychological Stress in Young Adults and Cognition in Midlife: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.

Journal Article J Am Heart Assoc · January 13, 2016 BACKGROUND: The classic view of blood pressure (BP) reactivity to psychological stress in relation to cardiovascular risks assumes that excess reactivity is worse and lower reactivity is better. Evidence addressing how stress-induced BP reactivity in young ... Full text Link to item Cite

Simulation of Daily Snapshot Rhythm Monitoring to Identify Atrial Fibrillation in Continuously Monitored Patients with Stroke Risk Factors.

Journal Article PLoS One · 2016 BACKGROUND: New technologies are diffusing into medical practice swiftly. Hand-held devices such as smartphones can record short-duration (e.g., 1-minute) ECGs, but their effectiveness in identifying patients with paroxysmal atrial fibrillation (AF) is unk ... Full text Link to item Cite

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.

Journal Article Lancet · December 5, 2015 BACKGROUND: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to p ... Full text Link to item Cite

Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition.

Journal Article Lancet · November 28, 2015 BACKGROUND: The Global Burden of Disease Study 2013 (GBD 2013) aims to bring together all available epidemiological data using a coherent measurement framework, standardised estimation methods, and transparent data sources to enable comparisons of health l ... Full text Link to item Cite

Nocturnal Blood Pressure in Young Adults and Cognitive Function in Midlife: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.

Journal Article Am J Hypertens · October 2015 BACKGROUND: Nocturnal blood pressure (BP) is associated with risk for cardiovascular events. However, the relationship between nocturnal BP in young adults and cognitive function in midlife remains unclear. METHODS: We used data from the ambulatory BP moni ... Full text Link to item Cite

Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.

Journal Article Lancet · August 22, 2015 BACKGROUND: Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 201 ... Full text Link to item Cite

Correlation of Central Blood Pressure to Hypertensive Target Organ Damages During Antihypertensive Treatment: The J-TOP Study.

Journal Article Am J Hypertens · August 2015 BACKGROUND: Some previous studies have shown that central blood pressure (BP) is more closely related to cardiovascular risks than brachial BP. This study compared the correlations between asymptomatic organ damages and each of central BP, brachial clinic ... Full text Link to item Cite

Reply: Interpreting Blood Pressure in Young Adults.

Journal Article J Am Coll Cardiol · July 21, 2015 Full text Link to item Cite

The Global Burden of Cancer 2013.

Journal Article JAMA Oncol · July 2015 IMPORTANCE: Cancer is among the leading causes of death worldwide. Current estimates of cancer burden in individual countries and regions are necessary to inform local cancer control strategies. OBJECTIVE: To estimate mortality, incidence, years lived with ... Full text Link to item Cite

Long-Term Blood Pressure Variability, New-Onset Diabetes Mellitus, and New-Onset Chronic Kidney Disease in the Japanese General Population.

Journal Article Hypertension · July 2015 Whether long-term blood pressure (BP) variability among individuals without diabetes mellitus is associated with new-onset chronic kidney disease (CKD) risk, independently of other BP parameters (eg, mean BP, cumulative exposure to BP) and metabolic profil ... Full text Link to item Cite

Estimation of the light shift in Ramsey-coherent population trapping

Conference 2015 Joint Conference of the IEEE International Frequency Control Symposium and the European Frequency and Time Forum, FCS 2015 - Proceedings · June 29, 2015 We both numerically and analytically investigate on the light shift in Ramsey-CPT resonance for compact atomic clocks. The numerical calculation of the light shift is based on a density matrix analysis in Λ-type three state model. And the analytical method ... Full text Cite

CPT pulse excitation method based on VCSEL current modulation for miniature atomic clocks

Conference 2015 Joint Conference of the IEEE International Frequency Control Symposium and the European Frequency and Time Forum, FCS 2015 - Proceedings · June 29, 2015 We propose a coherent population trapping (CPT) pulsed-excitation method based on direct drive-current modulation of a vertical-cavity surface-emitting LASER for miniature atomic clocks (MACs). Because our method needs only a simple device configuration wi ... Full text Cite

Racial differences in abnormal ambulatory blood pressure monitoring measures: Results from the Coronary Artery Risk Development in Young Adults (CARDIA) study.

Journal Article Am J Hypertens · May 2015 BACKGROUND: Several ambulatory blood pressure monitoring (ABPM) measures have been associated with increased cardiovascular disease risk independent of clinic blood pressure (BP). African Americans have higher clinic BP compared with Whites but few data ar ... Full text Link to item Cite

Sleep Blood Pressure Self-Measured at Home as a Novel Determinant of Organ Damage: Japan Morning Surge Home Blood Pressure (J-HOP) Study.

Journal Article J Clin Hypertens (Greenwich) · May 2015 To study whether sleep blood pressure (BP) self-measured at home is associated with organ damage, the authors analyzed the data of 2562 participants in the J-HOP study who self-measured sleep BP using a home BP monitoring (HBPM) device, three times during ... Full text Link to item Cite

Association of electrocardiographic left ventricular hypertrophy with incident cardiovascular disease in Japanese older hypertensive patients.

Journal Article Am J Hypertens · April 2015 BACKGROUND: Our aim was to assess whether electrocardiographic left ventricular hypertrophy (ECG-LVH) is associated with a higher risk of cardiovascular disease (CVD) events, independent of 24-hour blood pressure (BP) and circulating levels of norepinephri ... Full text Link to item Cite

Racial impact of diurnal variations in blood pressure on cardiovascular events in chronic kidney disease.

Journal Article J Am Soc Hypertens · April 2015 Ambulatory blood pressure parameters, nocturnal dipping and morning surge, are associated with cardiovascular outcomes in several populations. While significant variation exists between racial groups in ambulatory blood pressure measurements and the incide ... Full text Link to item Cite

Excess body mass index- and waist circumference-years and incident cardiovascular disease: the CARDIA study.

Journal Article Obesity (Silver Spring) · April 2015 OBJECTIVE: To determine the influence of the total cumulative exposure to excess overall and abdominal adiposity on the incidence of cardiovascular disease (CVD). METHODS: Prospective study of 4,061 white and black adults without CVD at baseline in 1985-19 ... Full text Link to item Cite

Isolated systolic hypertension in young and middle-aged adults and 31-year risk for cardiovascular mortality: the Chicago Heart Association Detection Project in Industry study.

Journal Article J Am Coll Cardiol · February 3, 2015 BACKGROUND: Isolated systolic hypertension (ISH), defined as systolic blood pressure (SBP) ≥140 mm Hg and diastolic blood pressure (DBP) <90 mm Hg, in younger and middle-aged adults is increasing in prevalence. OBJECTIVE: The aim of this study was to asses ... Full text Link to item Cite

Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.

Journal Article Lancet · January 10, 2015 BACKGROUND: Up-to-date evidence on levels and trends for age-sex-specific all-cause and cause-specific mortality is essential for the formation of global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013) we esti ... Full text Link to item Cite

Urinary Angiotensinogen Could Be a Prognostic Marker of Renoprotective Effects of Alogliptin in Patients with Type 2 Diabetes.

Journal Article J Diabetes Res · 2015 BACKGROUND: The aims of this study were (1) to examine the renoprotective effects of alogliptin and (2) to establish urinary angiotensinogen (AGT) as a prognostic marker of renoprotective effects of alogliptin in patients with type 2 diabetes (T2D). METHOD ... Full text Link to item Cite

Two-step pulse observation for Raman-Ramsey coherent population trapping atomic clocks

Journal Article Applied Physics Express · January 1, 2015 We propose a two-step pulse observation method to enhance the frequency stability of coherent population trapping (CPT) atomic clocks. The proposed method is a Raman-Ramsey scheme with low light intensity at resonance observation and provides a Ramsey-CPT ... Full text Cite

New-onset hypertension and risk for chronic kidney disease in the Japanese general population.

Journal Article J Hypertens · December 2014 OBJECTIVES: Our aims were to assess the progression rate of normotension and prehypertension to hypertension in Japan, and the effect of the new-onset hypertension on chronic kidney disease (CKD). METHODS: This was a nationwide study of 45 378 Japanese age ... Full text Link to item Cite

Nocturnal heart rate and inflammation.

Journal Article J Clin Hypertens (Greenwich) · December 2014 Full text Link to item Cite

High-contrast coherent population trapping based on crossed polarizers method

Journal Article IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control · December 1, 2014 A method based on crossed polarizers to observe high-contrast coherent population trapping (CPT) resonance has been developed. Because crossed polarizers have a simple optical system, our method is suitable for chip-scale atomic clocks (CSACs). In CPT, the ... Full text Cite

Long-term blood pressure variability throughout young adulthood and cognitive function in midlife: the Coronary Artery Risk Development in Young Adults (CARDIA) study.

Journal Article Hypertension · November 2014 Whether long-term blood pressure (BP) variability throughout young adulthood is associated with cognitive function in midlife remains uncertain. Using data from the Coronary Artery Risk Development in Young Adults (CARDIA), which recruited healthy young ad ... Full text Link to item Cite

Global, regional, and national levels and causes of maternal mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.

Journal Article Lancet · September 13, 2014 BACKGROUND: The fifth Millennium Development Goal (MDG 5) established the goal of a 75% reduction in the maternal mortality ratio (MMR; number of maternal deaths per 100,000 livebirths) between 1990 and 2015. We aimed to measure levels and track trends in ... Full text Link to item Cite

Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.

Journal Article Lancet · September 13, 2014 BACKGROUND: The Millennium Declaration in 2000 brought special global attention to HIV, tuberculosis, and malaria through the formulation of Millennium Development Goal (MDG) 6. The Global Burden of Disease 2013 study provides a consistent and comprehensiv ... Full text Link to item Cite

Theoretical and experimental investigation of the light shift in Ramsey coherent population trapping

Journal Article Physical Review A - Atomic, Molecular, and Optical Physics · July 21, 2014 The ac Stark shift (or light shift) of the 62S1/2(F=3↔4) transition in 133Cs, as observed through coherent population trapping under pulsed excitation, is measured using a 133Cs gas cell and the D1-line vertical-cavity surface-emitting laser. This light sh ... Full text Cite

Association of morning and evening blood pressure at home with asymptomatic organ damage in the J-HOP Study.

Journal Article Am J Hypertens · July 2014 BACKGROUND: Several guidelines recommend that home blood pressure (HBP) be measured both in the morning and in the evening. However, there have been fewer reports about the clinical significance of morning HBP than about the clinical significance of evenin ... Full text Link to item Cite

Association of high-sensitivity cardiac troponin T and N-terminal pro-brain-type natriuretic peptide with left ventricular structure: J-HOP study.

Journal Article J Clin Hypertens (Greenwich) · May 2014 Although both high-sensitivity cardiac troponin T (Hs-cTnT) and N-terminal pro-brain-type natriuretic peptide (NT-proBNP) levels are higher among patients with cardiac structural abnormalities than among those with apparently normal hearts, there is consid ... Full text Link to item Cite

Circulating des-acyl ghrelin improves cardiovascular risk prediction in older hypertensive patients.

Journal Article Am J Hypertens · May 2014 BACKGROUND: We aimed to assess the predictive value of circulating levels of des-acyl ghrelin, an abundant form of ghrelin in humans, for the risk of cardiovascular disease (CVD) in older hypertensive patients. We simultaneously evaluated other biomarkers, ... Full text Link to item Cite

Orthostatic hypotension associated with baroreceptor dysfunction: treatment approaches.

Journal Article J Clin Hypertens (Greenwich) · February 2014 Orthostatic hypotension (OH) is a relatively common heterogeneous and multifactorial disorder often caused by autonomic dysfunction. This condition has a deleterious impact on quality of life and contributes to higher mortality rates. Supine hypertension i ... Full text Link to item Cite

Effects of antihypertensive treatment in Asian populations: a meta-analysis of prospective randomized controlled studies (CARdiovascular protectioN group in Asia: CARNA).

Journal Article J Am Soc Hypertens · February 2014 To examine the effects of antihypertensive treatment on cardiovascular disease (CVD) in Asian populations, we systematically evaluated prospective randomized studies carried out in Asia (1991-2013). We identified 18 trials with 23,215 and 21,986 hypertensi ... Full text Link to item Cite

Association of cognitive dysfunction with cardiovascular disease events in elderly hypertensive patients.

Journal Article J Hypertens · February 2014 OBJECTIVES: This study assesses whether presence of cognitive dysfunction can be a marker associated with the development of cardiovascular disease (CVD) events independent of ambulatory blood pressure (BP) or other indices of target organ damage (TOD) in ... Full text Link to item Cite

Assessment of the reductions in night-time blood pressure and dipping induced by antihypertensive medication using a home blood pressure monitor.

Journal Article J Hypertens · January 2014 BACKGROUND: Night-time blood pressure (BP) is strongly associated with hypertensive target organ damage; however, no previous studies have compared home BP monitor measurements of the reduction in night-time BP induced by antihypertensive medications with ... Full text Link to item Cite

Investigation on light shift in CPT-Ramsey resonance for compact atomic clocks

Conference IFCS 2014 - 2014 IEEE International Frequency Control Symposium, Proceedings · January 1, 2014 This paper presents a theoretical and experimental investigation on the light shift (AC Stark shift) of the 62S1/2 (F = 3 ↔ 4) transition in 133Cs, as observed through coherent population trapping (CPT) under a pulsed excitation. The calculated results are ... Full text Cite

Study of an observation method based on crossed polarizers for high-contrast coherent population trapping

Conference 2013 Joint European Frequency and Time Forum and International Frequency Control Symposium, EFTF/IFC 2013 · December 1, 2013 In this paper, we propose an observation method based on crossed polarizers to obtain high-contrast coherent population trapping (CPT) resonance with parallel linearly polarized light (lin 11 lin field). Experimental results show that a high resonance cont ... Full text Cite

Higher-order sideband excitation method for pulsed CPT atomic clock

Conference 2013 Joint European Frequency and Time Forum and International Frequency Control Symposium, EFTF/IFC 2013 · December 1, 2013 We propose a higher-order sideband excitation method combined with pulse excitation to reduce power consumption of coherent population trapping (CPT) atomic clocks. Since higher-order sideband excitation enables reduction of radio frequency (RF), our metho ... Full text Cite

Efficacy of alogliptin, a dipeptidyl peptidase-4 inhibitor, on glucose parameters, the activity of the advanced glycation end product (AGE) - receptor for AGE (RAGE) axis and albuminuria in Japanese type 2 diabetes.

Journal Article Diabetes Metab Res Rev · November 2013 BACKGROUND: To examine the effects of alogliptin, a dipeptidyl peptidase-4 inhibitor, on glucose parameters, the advanced glycation end product (AGE)-receptor for AGE (RAGE) axis and albuminuria in Japanese type 2 diabetes patients. METHODS: Sixty-one pati ... Full text Link to item Cite

Associations between diabetes, leanness, and the risk of death in the Japanese general population: the Jichi Medical School Cohort Study.

Journal Article Diabetes Care · May 2013 OBJECTIVE: To examine the BMI-stratified associations between diabetes and the risks of all-cause death, cardiovascular disease (CVD) death, and cancer death. RESEARCH DESIGN AND METHODS: Using a prospective study with 12 rural Japanese general populations ... Full text Link to item Cite

The impact of cigarette smoking on 24-hour blood pressure, inflammatory and hemostatic activity, and cardiovascular risk in Japanese hypertensive patients.

Journal Article J Clin Hypertens (Greenwich) · April 2013 The aim of the study was to assess the impact of current smoking on 24-hour blood pressure (BP) and inflammatory and hemostatic activity and thereby the incidence of cardiovascular disease (CVD) in Japanese hypertensive patients. A total of 810 hypertensiv ... Full text Link to item Cite

Nighttime blood pressure, nighttime glucose values, and target-organ damages in treated type 2 diabetes patients.

Journal Article Atherosclerosis · March 2013 OBJECTIVE: The associations between nighttime blood pressure (BP) and cardiovascular risk are well established. However, the associations between nighttime glucose values, including nocturnal hypoglycemia, and cardiovascular risk in diabetes remain unclear ... Full text Link to item Cite

Both chronic kidney disease and nocturnal blood pressure associate with strokes in the elderly.

Journal Article Am J Nephrol · 2013 BACKGROUND: Among elderly hypertensive patients, we aimed to assess the association of nocturnal blood pressure (BP) pattern on stroke; interaction of dipping pattern with kidney disease was explored. METHODS: We retrospectively analyzed the records of 1,2 ... Full text Link to item Cite

Recognition and management of masked hypertension: a review and novel approach.

Journal Article J Am Soc Hypertens · 2013 Failure to show benefit in some cardiovascular and renal outcome trials may be a consequence of masked hypertension, a blood pressure in the hypertensive range outside the office setting. Ambulatory blood pressure monitoring and home blood pressures obtain ... Full text Link to item Cite

Associations of intrauterine growth restriction with placental pathological factors, maternal factors and fetal factors; clinicopathological findings of 257 Japanese cases.

Journal Article Histol Histopathol · January 2013 Intrauterine growth restriction (IUGR) is the leading cause of fetal mortality and morbidity. As an etiology, each of placental findings, maternal factors and fetal factors has been reported to be associated with IUGR, although a comprehensive approach to ... Full text Link to item Cite

Usefulness of carotid intima-media thickness measurement as an indicator of generalized atherosclerosis: findings from autopsy analysis.

Journal Article Atherosclerosis · December 2012 BACKGROUND: Ultrasound-determined carotid intima-media thickness (IMT) is widely used as an indicator of generalized atherosclerotic burden, but there are limited autopsy findings in support of the association, directly. METHODS: We performed an autopsy an ... Full text Link to item Cite

Pulse excitation method of coherent-population-trapping suitable for chip-scale atomic clock

Journal Article Japanese Journal of Applied Physics · December 1, 2012 We propose a pulse excitation method of coherent population trapping (CPT) with a liquid crystal optical modulator. Since liquid crystals enable reductions in size, weight, cost, and power consumption compared with acousto-optical modulators (AOMs), our me ... Full text Cite

Glycohemoglobin not as predictive as fasting glucose as a measure of prediabetes in predicting proteinuria.

Journal Article Nephrol Dial Transplant · October 2012 BACKGROUND: There is little data on the assessment of prediabetes with proteinuria. METHODS: This is a cross-sectional cohort study assessing prediabetes with proteinuria in a large Japanese population. Using a nationwide health checkup database of 228 778 ... Full text Link to item Cite

Association of sleep onset of acute coronary syndrome with sleep apnea syndrome and abnormal diurnal variation of hemostasis and adipokine levels.

Journal Article Blood Coagul Fibrinolysis · October 2012 Our aim was to examine the pathophysiology of sleep onset of acute coronary syndrome (ACS); in particular, we focused on the association of sleep onset of ACS, sleep-apnea syndrome (SAS), and diurnal variation of hemostasis and adipokine levels. Seventy-fo ... Full text Link to item Cite

The authors reply:

Journal Article Kidney International · August 2, 2012 Full text Cite

Is home blood pressure variability itself an interventional target beyond lowering mean home blood pressure during anti-hypertensive treatment?

Journal Article Hypertens Res · August 2012 It is unknown whether home blood pressure (BP) variability reduction is associated with target organ damage (TOD) protection independently of home mean BP reduction. We enrolled 310 hypertensive patients whose systolic BP (SBP) at home was over 135 mm Hg. ... Full text Link to item Cite

Nocturnal blood pressure and cardiovascular disease: a review of recent advances.

Journal Article Hypertens Res · July 2012 The accurate measurement, prediction and treatment of high blood pressure (BP) are essential issues in the management of hypertension. Ambulatory blood pressure monitoring (ABPM) has been shown to be superior to clinic BP measurements as ABPM can provide t ... Full text Link to item Cite

Nocturnal blood pressure, morning blood pressure surge, and cerebrovascular events.

Journal Article Curr Hypertens Rep · June 2012 Cerebrovascular disease is a common cause of death and major cause of disability worldwide. Even in silent cases (e.g., silent cerebral infarction, white matter lesion), cerebrovascular disease can lead to physical and cognitive impairment, thereby substan ... Full text Link to item Cite

Association of high pulse pressure with proteinuria in subjects with diabetes, prediabetes, or normal glucose tolerance in a large Japanese general population sample.

Journal Article Diabetes Care · June 2012 OBJECTIVE: To examine whether there is a difference in the association between high pulse pressure and proteinuria, independent of other blood pressure (BP) indices, such as systolic or diastolic BP, among subjects with diabetes, prediabetes, or normal glu ... Full text Link to item Cite

Independent association of cognitive dysfunction with cardiac hypertrophy irrespective of 24-h or sleep blood pressure in older hypertensives.

Journal Article Am J Hypertens · June 2012 BACKGROUND: Our aim was to assess whether cardiac hypertrophy is associated with cognitive function independently of office, 24-h, or sleep blood pressure (BP) levels in older hypertensive patients treated with antihypertensive medications. METHODS: In thi ... Full text Link to item Cite

Association between asleep blood pressure and brain natriuretic peptide during antihypertensive treatment: the Japan Morning Surge-Target Organ Protection (J-TOP) study.

Journal Article J Hypertens · May 2012 BACKGROUND: Asleep blood pressure (BP) has been shown to better reflect cardiovascular risk than awake BP in hypertensive patients. This study investigated the correlation of brain natriuretic peptide (BNP) to asleep BP during antihypertensive treatment. M ... Full text Link to item Cite

Lack of association between serum paraoxonase-1 activity and residual platelet aggregation during dual anti-platelet therapy.

Journal Article Thromb Res · April 2012 High residual platelet aggregability during thienopyridine treatment occurs because of low levels of the active drug metabolite, and is associated with an increased rate of major adverse cardiovascular events. Recent findings suggest that paraoxonase-1 (PO ... Full text Link to item Cite

Association of home and ambulatory blood pressure changes with changes in cardiovascular biomarkers during antihypertensive treatment.

Journal Article Am J Hypertens · March 2012 BACKGROUND: Our aim was to assess whether home blood pressure (HBP) and ambulatory BP monitoring measurement (ABPM), in addition to office BP (OBP) predict changes of cardiovascular biomarkers during antihypertensive treatment. METHODS: Two hundred and fif ... Full text Link to item Cite

Association between prehypertension and chronic kidney disease in the Japanese general population

Journal Article Kidney International · February 1, 2012 The increased prevalence of chronic kidney disease (CKD) is a consequence of the accumulation of risk factors, one of which is hypertension. Here we assessed the prevalence of CKD according to blood pressure among 232,025 patients in a Japanese nationwide ... Full text Cite

Morning blood pressure surge, morning platelet aggregation, and silent cerebral infarction in older Japanese hypertensive patients.

Journal Article J Hypertens · December 2011 OBJECTIVE: To examine whether or not the extent of morning blood pressure surge (MBPS), defined as a morning SBP increase from sleep SBP, is associated with that of platelet aggregation, coagulation/fibrinolytic activity, and silent cerebral infarction (SC ... Full text Link to item Cite

Synergistic effect of chronic kidney disease and high circulatory norepinephrine level on stroke risk in Japanese hypertensive patients.

Journal Article Atherosclerosis · November 2011 OBJECTIVE: Evidence is now available about the association between chronic kidney disease (CKD) and stroke. However, less is known about the underlying mechanisms, and there is currently no reliable marker for identifying stroke-prone high-risk patients am ... Full text Link to item Cite

The relationship between the morning blood pressure surge and low-grade inflammation on silent cerebral infarct and clinical stroke events.

Journal Article Atherosclerosis · November 2011 OBJECTIVE: Morning blood pressure surge (MBPS) has been shown to be a risk factor for cardiovascular disease and is associated with vascular remodeling. This study investigated whether the cerebrovascular risk of MBPS is modified by low-grade inflammation. ... Full text Link to item Cite

Efficacy of eplerenone added to renin-angiotensin blockade in elderly hypertensive patients: the Jichi-Eplerenone Treatment (JET) study.

Journal Article J Renin Angiotensin Aldosterone Syst · September 2011 INTRODUCTION: We assessed the additional effects of eplerenone to angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) on 24-h blood pressure (BP) level, fibrinolytic activity, and cardiovascular protection in elderly ... Full text Link to item Cite

Evening heart rate measured at home is associated with visceral obesity and abnormal fat distribution in patients with hypertension.

Journal Article Am J Hypertens · July 2011 BACKGROUND: Our aim was to examine the association between heart rate (HR) and visceral obesity and abnormal fat distribution in patients undergoing treatment for hypertension. We also ascertained whether such associations differ depending on the time of d ... Full text Link to item Cite

Mode shape visualization system for high-stability quartz resonators in high and continuously changing temperature

Journal Article Acoustical Science and Technology · May 9, 2011 The principal application of mode visualization is to the identification of unwanted weak-vibration modes that degrade the fundamental mode. Temperature variation measurement in the high temperature range is also required because the spurious modes general ... Full text Cite

Regional differences in hypertensive cardiovascular remodeling between fishing and farming communities in Japan.

Journal Article Am J Hypertens · April 2011 BACKGROUND: Effects of dietary n-3 polyunsaturated fatty acids (n-3 PUFA) intake on the cardiovascular system have been reported, and thus we hypothesized that the prevalence of hypertensive cardiovascular remodeling would be lower in a fishing than a farm ... Full text Link to item Cite

Association of poor physical function and cognitive dysfunction with high nocturnal blood pressure level in treated elderly hypertensive patients.

Journal Article Am J Hypertens · March 2011 BACKGROUND: Our aim was to assess the association between poor physical function, cognitive dysfunction, and high nocturnal systolic blood pressure (SBP), all of which are markers of vulnerability or frailty in elderly persons. METHODS: In this cross-secti ... Full text Link to item Cite

Additional impact of morning haemostatic risk factors and morning blood pressure surge on stroke risk in older Japanese hypertensive patients.

Journal Article Eur Heart J · March 2011 AIMS: Stroke events occur most frequently in the morning hours. Impaired haemostatic activity and morning blood pressure (BP) surge, defined as the morning BP increase from sleep, have individually been associated with stroke risk in general or hypertensiv ... Full text Link to item Cite

Real-time three-dimensional vibration mode visualization system based on laser speckle interference

Conference 2010 IEEE International Frequency Control Symposium, FCS 2010 · October 19, 2010 In this paper, we describe an improved system that visualizes the 3-D vibration modes on the device surface in quasi-real time without precision optical adjustment. We used three visible semiconductor lasers with adequately separated wavelengths. The incid ... Full text Cite

Mode shape measurement system with temperature variation function

Conference 2010 IEEE International Frequency Control Symposium, FCS 2010 · October 19, 2010 A measurement system with a temperature control function was developed for mapping the vibration patterns of piezoelectric resonator devices. This system is based on the laser speckle method with intermittent device excitation. By use of a small oven with ... Full text Cite

[Most recommended timing to start medication for hypertensive patients].

Journal Article Nihon Rinsho · September 2010 Hypertension is a major risk factor for cardiovascular disease. About forty million people are estimated to have hypertension. But, only 50% of hypertensive patients achieve well control of blood pressure. To prevent cardiovascular disease, more careful at ... Link to item Cite

Effect of dosing time of angiotensin II receptor blockade titrated by self-measured blood pressure recordings on cardiorenal protection in hypertensives: the Japan Morning Surge-Target Organ Protection (J-TOP) study.

Journal Article J Hypertens · July 2010 OBJECTIVES: To study the impact of the dosing time of an angiotensin II receptor blocker (ARB) titrated by self-measured home blood pressure (HBP) on cardiorenal damage in hypertensives. METHODS: We conducted an open-label multicenter trial, the J-TOP stud ... Full text Link to item Cite

Plasma Pentraxin 3, but not high-sensitivity C-reactive protein, is a useful inflammatory biomarker for predicting cognitive impairment in elderly hypertensive patients.

Journal Article J Gerontol A Biol Sci Med Sci · May 2010 BACKGROUND: Due to the increasing longevity of human populations worldwide, there is need of a useful biomarker for the early detection of cognitive impairment in elderly persons. Both high blood pressure (BP) and inflammatory processes have been reported ... Full text Link to item Cite

Association between morning blood pressure surge and cardiovascular remodeling in treated elderly hypertensive subjects.

Journal Article Am J Hypertens · November 2009 BACKGROUND: It has remained unclear whether or not morning blood pressure (BP) surge (MS) is associated with cardiovascular remodeling in elderly (> or =60 years) hypertensive patients being treated by antihypertensive medications. METHODS: In this cross-s ... Full text Link to item Cite

Plasma des-acyl ghrelin, but not plasma HMW adiponectin, is a useful cardiometabolic marker for predicting atherosclerosis in elderly hypertensive patients.

Journal Article Atherosclerosis · June 2009 OBJECTIVE: The coming obesity epidemic in elderly persons necessitates the establishment of new and easy-to-use cardiometabolic markers to identify individuals most likely to develop atherosclerosis among hypertensives. METHODS: We measured plasma HMW adip ... Full text Link to item Cite

[The clinical utility of angiotensin receptor blockers in out-of-office hypertension (masked hypertension, workplace hypertension, and home hypertension)].

Journal Article Nihon Rinsho · April 2009 The pathological mechanisms of out-of-office hypertension (e.g., masked hypertension and workplace hypertension) have been remained unclear, but several mechanisms for this unique phenomenon have been proposed. Altered neurohumoral regulations, increased a ... Link to item Cite

Blood pressure management in metabolic syndrome

Journal Article Current Hypertension Reviews · October 10, 2008 To assess 24-hour BP levels in subjects with metabolic syndrome is essential, because hypertension, which is the most prevalent component in the syndrome, makes the major contribution to cardiovascular risk. Because BP levels in subjects with metabolic syn ... Full text Cite

Determinants of thrombin generation, fibrinolytic activity, and endothelial dysfunction in patients on dual antiplatelet therapy: involvement of factors other than platelet aggregability in Virchow's triad.

Journal Article Eur Heart J · July 2008 AIMS: The aim of the study was to assess mechanisms and clinical backgrounds in order to determine residual platelet aggregability in dual antiplatelet therapy and to ascertain whether platelet aggregability is involved in systemic thrombogenicity. METHODS ... Full text Link to item Cite

Differential impacts of adiponectin on low-grade albuminuria between obese and nonobese persons without diabetes.

Journal Article J Clin Hypertens (Greenwich) · October 2007 The goal of this study was to examine the association between adiponectin and low-grade albuminuria in nondiabetic persons and whether it differed between obese and nonobese individuals. Urinary albumin excretion (UAE) was assessed by overnight collection ... Full text Link to item Cite

The differential effects of angiotensin II type 1 receptor blockers on microalbuminuria in relation to low-grade inflammation in metabolic hypertensive patients.

Journal Article Am J Hypertens · May 2007 BACKGROUND: A dual angiotensin type 1 receptor blocker (ARB)/peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist telmisartan may be more useful for microalbuminuria reduction than ARBs with no PPARgamma agonistic action. We investigated wh ... Full text Link to item Cite

A case of reversible posterior leukoencephalopathy syndrome caused by transient hypercoagulable state induced by infection.

Journal Article Hypertens Res · July 2005 We report a normotensive case of reversible posterior leukoencephalopathy syndrome caused by transient hypercoagulable state. Hypertension is the main risk factor for reversible posterior leukoencephalopathy syndrome, which is believed to occur as a result ... Full text Link to item Cite

Morning Surge in Blood Pressure and Cardiovascular Disease

Journal Article Respiration and Circulation · May 1, 2004 Cite

Effects of arotinolol hydrochloride on circadian rhythm of blood pressure in patients with essential hypertention

Journal Article IRYO - Japanese Journal of National Medical Services · August 31, 1998 The introduction of 24-hour monitoring of blood pressure using ambulatory blood pressure monitoring (ABPM) has revealed the presence of white coat hypertension, a sudden blood pressure rise in early morning (morning surge), and dipper and non-dipper type o ... Cite