Scholars@Duke
Stefan Zauscher

Stefan Zauscher

Professor in the Thomas Lord Department of Mechanical Engineering and Materials Science
Thomas Lord Department of Mechanical Engineering and Materials Science
zauscher@duke.edu
3385 Fciemas Building, Box 90300, Durham, NC 27708-0300
3385 Fciemas Building, Box 90300, Durham, NC 27708
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Selected Publications

Branched poly-l-lysine for cartilage penetrating carriers.

Journal Article Bioeng Transl Med · May 2024 Joint diseases, such as osteoarthritis, often require delivery of drugs to chondrocytes residing within the cartilage. However, intra-articular delivery of drugs to cartilage remains a challenge due to their rapid clearance within the joint. This problem i ... Full text Link to item Cite

Innovations in colloid and interface science: Revolutionizing antimicrobial therapeutics

Journal Article Current Opinion in Colloid and Interface Science · April 1, 2024 Full text Cite

Enzymatic Synthesis of Aptamer-Polynucleotide Nanoparticles with High Anticancer Drug Loading for Targeted Delivery.

Journal Article Biomacromolecules · January 2024 We report a targeted prodrug delivery platform that can deliver a cytostatic nucleobase analog with high drug loading. We chose fluorouracil (5FU), a drug used to treat various cancers, whose active metabolite 5-fluorodeoxyuridine monophosphate (5-FdUMP) i ... Full text Cite

Controlling Silicification on DNA Origami with Polynucleotide Brushes.

Journal Article Journal of the American Chemical Society · January 2024 DNA origami has been used as biotemplates for growing a range of inorganic materials to create novel organic-inorganic hybrid nanomaterials. Recently, the solution-based silicification of DNA has been used to grow thin silica shells on DNA origami. However ... Full text Cite

Spatiotemporal Control over Polynucleotide Brush Growth on DNA Origami Nanostructures

Journal Article Angewandte Chemie · November 27, 2023 AbstractDNA nanotechnology provides an approach to create precise, tunable, and biocompatible nanostructures for biomedical applications. However, the stability of these structures is severely compromised in biological mili ... Full text Cite

Polyelectrolyte brushes affect the adsorption kinetics of nanoparticles onto lipid membranes

Journal Article Colloids and Surfaces A: Physicochemical and Engineering Aspects · November 20, 2023 This article explores the adsorption kinetics of positively charged hard and soft silica nanoparticles (NPs) on supported lipid bilayers (SLBs) with an anionic surface charge. The softness of the NPs is adjusted by varying the grafting density of covalentl ... Full text Cite

Spatiotemporal Control over Polynucleotide Brush Growth on DNA Origami Nanostructures.

Journal Article Angewandte Chemie (International ed. in English) · November 2023 DNA nanotechnology provides an approach to create precise, tunable, and biocompatible nanostructures for biomedical applications. However, the stability of these structures is severely compromised in biological milieu due to their fast degradation by nucle ... Full text Cite

Progress in the design and synthesis of viscosupplements for articular joint lubrication

Journal Article Current Opinion in Colloid and Interface Science · August 1, 2023 Throughout a lifetime, articular joints experience many loading cycles and are prone to mechanical degradation. To safeguard the cartilage in these joints, the synovial fluid acts as a natural lubricant. However, degenerative joint diseases, like osteoarth ... Full text Cite

The energetics of rapid cellular mechanotransduction.

Journal Article Proc Natl Acad Sci U S A · February 21, 2023 Cells throughout the human body detect mechanical forces. While it is known that the rapid (millisecond) detection of mechanical forces is mediated by force-gated ion channels, a detailed quantitative understanding of cells as sensors of mechanical energy ... Full text Link to item Cite

Self-Assembled Single-Stranded DNA Nano-Networks in Solution and at Surfaces.

Journal Article Biomacromolecules · March 2022 We studied the directed self-assembly of two types of complementary single-stranded DNA (ssDNA) strands [i.e., poly(dA) and poly(dT)] into more complex, organized, and percolating networks in dilute solutions and at surfaces. Understanding ssDNA self-assem ... Full text Cite

Self-Healing of Hyaluronic Acid to Improve In Vivo Retention and Function.

Journal Article Adv Healthc Mater · December 2021 Convergent advances in the field of soft matter, macromolecular chemistry, and engineering have led to the development of biomaterials that possess autonomous, adaptive, and self-healing characteristics similar to living systems. These rationally designed ... Full text Link to item Cite

Programmable Site‐Specific Functionalization of DNA Origami with Polynucleotide Brushes

Journal Article Angewandte Chemie · October 18, 2021 AbstractCombining surface‐initiated, TdT (terminal deoxynucleotidyl transferase) catalyzed enzymatic polymerization (SI‐TcEP) with precisely engineered DNA origami nanostructures (DONs) presents an innovative pathway for th ... Full text Cite

Programmable Site-Specific Functionalization of DNA Origami with Polynucleotide Brushes.

Journal Article Angewandte Chemie (International ed. in English) · October 2021 Combining surface-initiated, TdT (terminal deoxynucleotidyl transferase) catalyzed enzymatic polymerization (SI-TcEP) with precisely engineered DNA origami nanostructures (DONs) presents an innovative pathway for the generation of stable, polynucleotide br ... Full text Cite

Microphase Separation of Resilin-like and Elastin-like Diblock Copolypeptides in Concentrated Solutions.

Journal Article Biomacromolecules · September 2021 Diblock copolymers are valued for their ability to form thin films with nanoscale features that typically reflect those of their microphase-separated structures in concentrated solution. Here, we show that such self-assembled structures can be easily forme ... Full text Cite

Interaction of Proteins with a Planar Poly(acrylic acid) Brush: Analysis by Quartz Crystal Microbalance with Dissipation Monitoring (QCM-D).

Journal Article Polymers · December 2020 We describe the preparation of a poly(acrylic acid) (PAA) brush, polymerized by atom transfer radical polymerization (ATRP) of tert-butyl acrylate (tBA) and subsequent acid hydrolysis, on the flat gold surfaces of quartz-crystal microbalance ... Full text Cite

Controlled Lengthwise Assembly of Helical Peptide Nanofibers to Modulate CD8+ T-Cell Responses.

Journal Article Advanced materials (Deerfield Beach, Fla.) · October 2020 Peptide nanofibers are useful for many biological applications, including immunotherapy, tissue engineering, and drug delivery. The robust lengthwise assembly of these peptides into nanofibers is typically difficult to control, resulting in polydisperse fi ... Full text Cite

Understanding and Mapping Sensitivity in MoS2 Field-Effect-Transistor-Based Sensors.

Journal Article ACS nano · September 2020 Sensors based on two-dimensional (2D) field-effect transistors (FETs) are extremely sensitive and can detect charged analytes with attomolar limits of detection (LOD). Despite some impressive LODs, the operating mechanisms and factors that determine the si ... Full text Cite

Grafting To of Bottlebrush Polymers: Conformation and Kinetics.

Journal Article Langmuir : the ACS journal of surfaces and colloids · May 2020 Specifically adsorbed bottlebrush coatings are found in nature as brush-like glycoproteins that decorate biointerfaces and provide antifouling, lubrication, or wear-protection. Although various synthetic strategies have been developed to mimic glycoprotein ... Full text Cite

Ti3C2Tx MXene-Reduced Graphene Oxide Composite Electrodes for Stretchable Supercapacitors.

Journal Article ACS nano · March 2020 The development of stretchable electronics requires the invention of compatible high-performance power sources, such as stretchable supercapacitors and batteries. In this work, two-dimensional (2D) titanium carbide (Ti3C2Tx Full text Cite

Branched poly-l-lysine for cartilage penetrating carriers.

Journal Article Bioeng Transl Med · May 2024 Joint diseases, such as osteoarthritis, often require delivery of drugs to chondrocytes residing within the cartilage. However, intra-articular delivery of drugs to cartilage remains a challenge due to their rapid clearance within the joint. This problem i ... Full text Link to item Cite

Innovations in colloid and interface science: Revolutionizing antimicrobial therapeutics

Journal Article Current Opinion in Colloid and Interface Science · April 1, 2024 Full text Cite

Enzymatic Synthesis of Aptamer-Polynucleotide Nanoparticles with High Anticancer Drug Loading for Targeted Delivery.

Journal Article Biomacromolecules · January 2024 We report a targeted prodrug delivery platform that can deliver a cytostatic nucleobase analog with high drug loading. We chose fluorouracil (5FU), a drug used to treat various cancers, whose active metabolite 5-fluorodeoxyuridine monophosphate (5-FdUMP) i ... Full text Cite

Controlling Silicification on DNA Origami with Polynucleotide Brushes.

Journal Article Journal of the American Chemical Society · January 2024 DNA origami has been used as biotemplates for growing a range of inorganic materials to create novel organic-inorganic hybrid nanomaterials. Recently, the solution-based silicification of DNA has been used to grow thin silica shells on DNA origami. However ... Full text Cite

Spatiotemporal Control over Polynucleotide Brush Growth on DNA Origami Nanostructures

Journal Article Angewandte Chemie · November 27, 2023 AbstractDNA nanotechnology provides an approach to create precise, tunable, and biocompatible nanostructures for biomedical applications. However, the stability of these structures is severely compromised in biological mili ... Full text Cite

Polyelectrolyte brushes affect the adsorption kinetics of nanoparticles onto lipid membranes

Journal Article Colloids and Surfaces A: Physicochemical and Engineering Aspects · November 20, 2023 This article explores the adsorption kinetics of positively charged hard and soft silica nanoparticles (NPs) on supported lipid bilayers (SLBs) with an anionic surface charge. The softness of the NPs is adjusted by varying the grafting density of covalentl ... Full text Cite

Spatiotemporal Control over Polynucleotide Brush Growth on DNA Origami Nanostructures.

Journal Article Angewandte Chemie (International ed. in English) · November 2023 DNA nanotechnology provides an approach to create precise, tunable, and biocompatible nanostructures for biomedical applications. However, the stability of these structures is severely compromised in biological milieu due to their fast degradation by nucle ... Full text Cite

Progress in the design and synthesis of viscosupplements for articular joint lubrication

Journal Article Current Opinion in Colloid and Interface Science · August 1, 2023 Throughout a lifetime, articular joints experience many loading cycles and are prone to mechanical degradation. To safeguard the cartilage in these joints, the synovial fluid acts as a natural lubricant. However, degenerative joint diseases, like osteoarth ... Full text Cite

The energetics of rapid cellular mechanotransduction.

Journal Article Proc Natl Acad Sci U S A · February 21, 2023 Cells throughout the human body detect mechanical forces. While it is known that the rapid (millisecond) detection of mechanical forces is mediated by force-gated ion channels, a detailed quantitative understanding of cells as sensors of mechanical energy ... Full text Link to item Cite

Self-Assembled Single-Stranded DNA Nano-Networks in Solution and at Surfaces.

Journal Article Biomacromolecules · March 2022 We studied the directed self-assembly of two types of complementary single-stranded DNA (ssDNA) strands [i.e., poly(dA) and poly(dT)] into more complex, organized, and percolating networks in dilute solutions and at surfaces. Understanding ssDNA self-assem ... Full text Cite

Self-Healing of Hyaluronic Acid to Improve In Vivo Retention and Function.

Journal Article Adv Healthc Mater · December 2021 Convergent advances in the field of soft matter, macromolecular chemistry, and engineering have led to the development of biomaterials that possess autonomous, adaptive, and self-healing characteristics similar to living systems. These rationally designed ... Full text Link to item Cite

Programmable Site‐Specific Functionalization of DNA Origami with Polynucleotide Brushes

Journal Article Angewandte Chemie · October 18, 2021 AbstractCombining surface‐initiated, TdT (terminal deoxynucleotidyl transferase) catalyzed enzymatic polymerization (SI‐TcEP) with precisely engineered DNA origami nanostructures (DONs) presents an innovative pathway for th ... Full text Cite

Programmable Site-Specific Functionalization of DNA Origami with Polynucleotide Brushes.

Journal Article Angewandte Chemie (International ed. in English) · October 2021 Combining surface-initiated, TdT (terminal deoxynucleotidyl transferase) catalyzed enzymatic polymerization (SI-TcEP) with precisely engineered DNA origami nanostructures (DONs) presents an innovative pathway for the generation of stable, polynucleotide br ... Full text Cite

Microphase Separation of Resilin-like and Elastin-like Diblock Copolypeptides in Concentrated Solutions.

Journal Article Biomacromolecules · September 2021 Diblock copolymers are valued for their ability to form thin films with nanoscale features that typically reflect those of their microphase-separated structures in concentrated solution. Here, we show that such self-assembled structures can be easily forme ... Full text Cite

Interaction of Proteins with a Planar Poly(acrylic acid) Brush: Analysis by Quartz Crystal Microbalance with Dissipation Monitoring (QCM-D).

Journal Article Polymers · December 2020 We describe the preparation of a poly(acrylic acid) (PAA) brush, polymerized by atom transfer radical polymerization (ATRP) of tert-butyl acrylate (tBA) and subsequent acid hydrolysis, on the flat gold surfaces of quartz-crystal microbalance ... Full text Cite

Controlled Lengthwise Assembly of Helical Peptide Nanofibers to Modulate CD8+ T-Cell Responses.

Journal Article Advanced materials (Deerfield Beach, Fla.) · October 2020 Peptide nanofibers are useful for many biological applications, including immunotherapy, tissue engineering, and drug delivery. The robust lengthwise assembly of these peptides into nanofibers is typically difficult to control, resulting in polydisperse fi ... Full text Cite

Understanding and Mapping Sensitivity in MoS2 Field-Effect-Transistor-Based Sensors.

Journal Article ACS nano · September 2020 Sensors based on two-dimensional (2D) field-effect transistors (FETs) are extremely sensitive and can detect charged analytes with attomolar limits of detection (LOD). Despite some impressive LODs, the operating mechanisms and factors that determine the si ... Full text Cite

Grafting To of Bottlebrush Polymers: Conformation and Kinetics.

Journal Article Langmuir : the ACS journal of surfaces and colloids · May 2020 Specifically adsorbed bottlebrush coatings are found in nature as brush-like glycoproteins that decorate biointerfaces and provide antifouling, lubrication, or wear-protection. Although various synthetic strategies have been developed to mimic glycoprotein ... Full text Cite

Ti3C2Tx MXene-Reduced Graphene Oxide Composite Electrodes for Stretchable Supercapacitors.

Journal Article ACS nano · March 2020 The development of stretchable electronics requires the invention of compatible high-performance power sources, such as stretchable supercapacitors and batteries. In this work, two-dimensional (2D) titanium carbide (Ti3C2Tx Full text Cite

Complex microparticle architectures from stimuli-responsive intrinsically disordered proteins.

Journal Article Nature communications · March 2020 The controllable production of microparticles with complex geometries is useful for a variety of applications in materials science and bioengineering. The formation of intricate microarchitectures typically requires sophisticated fabrication techniques suc ... Full text Cite

Effect of Octadecylamine Surfactant on DNA Interactions with Graphene Surfaces.

Journal Article Langmuir : the ACS journal of surfaces and colloids · February 2020 Understanding of how to integrate DNA molecules with graphene materials is important for the development of biosensors and biomolecular logic circuits. For some of these applications, controlling DNA structural conformation on the graphene substrate is cri ... Full text Cite

Thermodynamic Analysis of the Uptake of a Protein in a Spherical Polyelectrolyte Brush.

Journal Article Macromolecular rapid communications · January 2020 A thermodynamic study of the adsorption of Human Serum Albumin (HSA) onto spherical polyelectrolyte brushes (SPBs) by isothermal titration calorimetry (ITC) is presented. The SPBs are composed of a solid polystyrene core bearing long chains of poly(acrylic ... Full text Cite

Shear Modulus Measurement by Quantitative Phase Imaging and Correlation with Atomic Force Microscopy.

Journal Article Biophysical journal · August 2019 Many approaches have been developed to characterize cell elasticity. Among these, atomic force microscopy (AFM) combined with modeling has been widely used to characterize cellular compliance. However, such approaches are often limited by the difficulties ... Full text Cite

Interaction between Soft Nanoparticles and Phospholipid Membranes: Effect of the Polymer-Grafting Density on Nanoparticle Adsorption

Journal Article ACS Applied Nano Materials · April 26, 2019 Nanoparticles (NPs) have large potential for biological applications as typically they exhibit strongly size-dependent properties. Specifically, the interaction of NPs with phospholipid membranes is of significant relevance to nanomedicine and the related ... Full text Cite

Enzymatic synthesis of aptamer-targeted polynucleotide drugs for cancer therapy

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · March 31, 2019 Link to item Cite

Bio-inspired peptide-polymer hybrid mucin analogues: Applications in osteoarthritis and kidney stone disease

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · March 31, 2019 Link to item Cite

Synthesis of modular brush polymer-protein hybrids using diazotransfer and copper click chemistry

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · March 31, 2019 Link to item Cite

Enzymatically Degassed Surface-Initiated Atom Transfer Radical Polymerization with Real-Time Monitoring.

Journal Article Journal of the American Chemical Society · February 2019 Polymer brush coatings are frequently prepared by radical polymerization, a notoriously oxygen sensitive process. Glucose oxidase (GOx) can inexpensively enable radical polymerization in solution by enzymatically consuming oxygen as it oxidizes glucose. He ... Full text Cite

Enzymatic synthesis and modification of high molecular weight DNA using terminal deoxynucleotidyl transferase.

Chapter · January 2019 The recognition that nucleic acids can be used as polymeric materials led to the blossoming of the field of DNA nanotechnology, with a broad range of applications in biotechnology, biosensors, diagnostics, and drug delivery. These applications require effi ... Full text Cite

Advances in mucin mimic synthesis and applications in surface science

Journal Article Current Opinion in Colloid and Interface Science · November 1, 2018 Mucins are a class of glycoproteins that serve key roles in tissue protection, hydration, and lubrication. However, their study and application are complicated by their post-translational modifications, heterogeneity, and their propensity to deteriorate up ... Full text Cite

Biosynthetic transition metal chalcogenide semiconductor nanoparticles: Progress in synthesis, property control and applications

Journal Article Current Opinion in Colloid and Interface Science · November 1, 2018 Transition metal (TM) chalcogenides are a group of semiconductor materials with applications that range from antibacterial particles to thin films in energy conversion devices. Significant progress in synthetic biology combined with the benefits of low ene ... Full text Cite

Editorial overview: Colloids and surfaces in biology

Journal Article Current Opinion in Colloid and Interface Science · November 1, 2018 Full text Cite

Enhanced Release of Molecules upon Ultraviolet (UV) Light Irradiation from Photoresponsive Hydrogels Prepared from Bifunctional Azobenzene and Four-Arm Poly(ethylene glycol).

Journal Article ACS applied materials & interfaces · September 2018 Advances in biosensors and drug delivery are dependent on hydrogels that respond to external stimuli. In this work, we describe the preparation and characterization of photoresponsive hydrogels prepared by cross-linking of di-NHS ester of azobenzoic acid a ... Full text Cite

Encapsulation, protection and programmed release of retinol from silicone particles for topical applications

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 19, 2018 Link to item Cite

The enduring utility of azobenzene as a photocontrol unit in hybrid macromolecular systems

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 19, 2018 Link to item Cite

Enzymatic Synthesis of Nucleobase-Modified Single-Stranded DNA Offers Tunable Resistance to Nuclease Degradation.

Journal Article Biomacromolecules · August 2018 We synthesized long, nucleobase-modified, single-stranded DNA (ssDNA) using terminal deoxynucleotidyl transferase (TdT) enzymatic polymerization. Specifically, we investigated the effect of unnatural nucleobase size and incorporation density on ssDNA resis ... Full text Cite

Synthesis of Modular Brush Polymer-Protein Hybrids Using Diazotransfer and Copper Click Chemistry.

Journal Article Bioconjugate chemistry · August 2018 Proteoglycans are important brush-like biomacromolecules, which serve a variety of functions in the human body. While protein-bottlebrush hybrids are promising proteoglycan mimics, many challenges still exist to robustly produce such polymers. In this pape ... Full text Cite

On-demand release of Candida albicans biofilms from urinary catheters by mechanical surface deformation.

Journal Article Biofouling · July 2018 Candida albicans is a leading cause of catheter-associated urinary tract infections and elimination of these biofilm-based infections without antifungal agents would constitute a significant medical advance. A novel urinary catheter prototype that utilizes ... Full text Link to item Cite

Encapsulation and controlled release of retinol from silicone particles for topical delivery.

Journal Article Journal of controlled release : official journal of the Controlled Release Society · May 2018 Retinol, a derivative of vitamin A, is a ubiquitous compound used to treat acne, reduce wrinkles and protect against conditions like psoriasis and ichthyosis. While retinol is used as the primary active ingredient (AI) in many skin care formulations, its e ... Full text Cite

Functional Modification of Silica through Enhanced Adsorption of Elastin-Like Polypeptide Block Copolymers.

Journal Article Biomacromolecules · February 2018 A powerful tool for controlling interfacial properties and molecular architecture relies on the tailored adsorption of stimuli-responsive block copolymers onto surfaces. Here, we use computational and experimental approaches to investigate the adsorption b ... Full text Cite

Photo-Crosslinkable Unnatural Amino Acids Enable Facile Synthesis of Thermoresponsive Nano- to Microgels of Intrinsically Disordered Polypeptides.

Journal Article Advanced materials (Deerfield Beach, Fla.) · February 2018 Hydrogel particles are versatile materials that provide exquisite, tunable control over the sequestration and delivery of materials in pharmaceutics, tissue engineering, and photonics. The favorable properties of hydrogel particles depend largely on their ... Full text Cite

Bacterially driven cadmium sulfide precipitation on porous membranes: Toward platforms for photocatalytic applications.

Journal Article Biointerphases · February 2018 The emerging field of biofabrication capitalizes on nature's ability to create materials with a wide range of well-defined physical and electronic properties. Particularly, there is a current push to utilize programmed, self-organization of living cells fo ... Full text Cite

Doxorubicin-loaded protease-activated near-infrared fluorescent polymeric nanoparticles for imaging and therapy of cancer.

Journal Article International journal of nanomedicine · January 2018 IntroductionDespite significant progress in the field of oncology, cancer remains one of the leading causes of death. Chemotherapy is one of the most common treatment options for cancer patients but is well known to result in off-target toxicity. ... Full text Cite

Programmable assembly of pressure sensors using pattern-forming bacteria.

Journal Article Nat Biotechnol · November 2017 Biological systems can generate microstructured materials that combine organic and inorganic components and possess diverse physical and chemical properties. However, these natural processes in materials fabrication are not readily programmable. Here, we u ... Full text Link to item Cite

Salt Responsive Morphologies of ssDNA-Based Triblock Polyelectrolytes in Semi-Dilute Regime: Effect of Volume Fractions and Polyelectrolyte Length.

Journal Article Macromolecular rapid communications · October 2017 A comprehensive study is reported on the effect of salt concentration, polyelectrolyte block length, and polymer concentration on the morphology and structural properties of nanoaggregates self-assembled from BAB single-strand DNA (ssDNA) triblock polynucl ... Full text Cite

Two-Dimensional Lead(II) Halide-Based Hybrid Perovskites Templated by Acene Alkylamines: Crystal Structures, Optical Properties, and Piezoelectricity.

Journal Article Inorganic chemistry · August 2017 A series of two-dimensional (2D) hybrid organic-inorganic perovskite (HOIP) crystals, based on acene alkylamine cations (i.e., phenylmethylammonium (PMA), 2-phenylethylammonium (PEA), 1-(2-naphthyl)methanammonium (NMA), and 2-(2-naphthyl)ethanammonium (NEA ... Full text Cite

High‐Molecular‐Weight Polynucleotides by Transferase‐Catalyzed Living Chain‐Growth Polycondensation

Journal Article Angewandte Chemie · June 6, 2017 AbstractWe present terminal deoxynucleotidyl transferase‐catalyzed enzymatic polymerization (TcEP) for the template‐free synthesis of high‐molecular‐weight, single‐stranded DNA (ssDNA) and demonstrate that it proceeds by a ... Full text Cite

High-Molecular-Weight Polynucleotides by Transferase-Catalyzed Living Chain-Growth Polycondensation.

Journal Article Angewandte Chemie (International ed. in English) · June 2017 We present terminal deoxynucleotidyl transferase-catalyzed enzymatic polymerization (TcEP) for the template-free synthesis of high-molecular-weight, single-stranded DNA (ssDNA) and demonstrate that it proceeds by a living chain-growth polycondensation mech ... Full text Cite

Subsurface structure fingerprint of 2D materials and heterostructures by their nanomechanical response

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · April 2, 2017 Link to item Cite

Synthesis and characterization of supported lipid bilayer membranes from complex lipid mixtures

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · April 2, 2017 Link to item Cite

Interfacial Mechanical Properties of Graphene on Self-Assembled Monolayers: Experiments and Simulations.

Journal Article ACS applied materials & interfaces · March 2017 Self-assembled monolayers (SAMs) have been widely used to engineer the electronic properties of substrate-supported graphene devices. However, little is known about how the surface chemistry of SAMs affects the interfacial mechanical properties of graphene ... Full text Cite

Hybrid (Organic/Inorganic) Electrodes from Bacterially Precipitated CdS for PEC/Storage Applications

Journal Article Journal of Physical Chemistry C · February 23, 2017 Hybrid organic-inorganic compounds are receiving increasing attention for photoelectrochemical (PEC) devices due to their high electron transport efficiency and facile synthesis. Biosynthesis is a potentially low-cost and eco-friendly method to precipitate ... Full text Cite

Hybrid (organic/inorganic) electrode design from bacterially precipitated CdS for PEC/storage applications

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · 2017 Cite

Quantitative Subsurface Atomic Structure Fingerprint for 2D Materials and Heterostructures by First-Principles-Calibrated Contact-Resonance Atomic Force Microscopy.

Journal Article ACS nano · July 2016 Interfaces and subsurface layers are critical for the performance of devices made of 2D materials and heterostructures. Facile, nondestructive, and quantitative ways to characterize the structure of atomically thin, layered materials are thus essential to ... Full text Cite

Nanopatterned polymer brushes: conformation, fabrication and applications.

Journal Article Nanoscale · January 2016 Surfaces with end-grafted, nanopatterned polymer brushes that exhibit well-defined feature dimensions and controlled chemical and physical properties provide versatile platforms not only for investigation of nanoscale phenomena at biointerfaces, but also f ... Full text Cite

Cadmium sulphide quantum dots with tunable electronic properties by bacterial precipitation.

Journal Article RSC advances · January 2016 We present a new method to fabricate semiconducting, transition metal nanoparticles (NPs) with tunable bandgap energies using engineered Escherichia coli. These bacteria overexpress the Treponema denticola cysteine desulfhydrase gene to facil ... Full text Cite

Large-Scale microRNA Expression Profiling Identifies Putative Retinal miRNA-mRNA Signaling Pathways Underlying Form-Deprivation Myopia in Mice.

Journal Article PLoS One · 2016 Development of myopia is associated with large-scale changes in ocular tissue gene expression. Although differential expression of coding genes underlying development of myopia has been a subject of intense investigation, the role of non-coding genes such ... Full text Open Access Link to item Cite

Photocontrolled micellar aggregation of amphiphilic DNA-azobenzene conjugates.

Journal Article Colloids and surfaces. B, Biointerfaces · November 2015 We demonstrate the reversible micellar aggregation of a DNA-azobenzene conjugate in aqueous conditions, in which the photoisomerization of the initially apolar trans-azobenzene moiety to the polar cis isomer causes disassembly of the aggregates. The molecu ... Full text Cite

Prediction of solvent-induced morphological changes of polyelectrolyte diblock copolymer micelles.

Journal Article Soft matter · November 2015 Self-assembly processes of polyelectrolyte block copolymers are ubiquitous in industrial and biological processes; understanding their physical properties can also provide insights into the design of polyelectrolyte materials with novel and tailored proper ... Full text Cite

Synthesis of photoresponsive single stranded DNA aggregates via click chemistry

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · March 22, 2015 Link to item Cite

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.

Journal Article Proc Natl Acad Sci U S A · November 25, 2014 Diarthrodial joints are essential for load bearing and locomotion. Physiologically, articular cartilage sustains millions of cycles of mechanical loading. Chondrocytes, the cells in cartilage, regulate their metabolic activities in response to mechanical l ... Full text Open Access Link to item Cite

Liquid contact resonance AFM: analytical models, experiments, and limitations.

Journal Article Nanotechnology · November 2014 Contact resonance AFM (CR-AFM) is a scanning probe microscopy technique that utilizes the contact resonances of the AFM cantilever for concurrent imaging of topography and surface stiffness. The technique has not been used in liquid until recently due to a ... Full text Cite

HIV-1 antibodies and vaccine antigen selectively interact with lipid domains.

Journal Article Biochim Biophys Acta · October 2014 The rare, broadly neutralizing antibodies, 4E10 and 2F5, that target the HIV-1 membrane proximal external region also associate with HIV-1 membrane lipids as part of a required first-step in HIV-1 neutralization. HIV-1 virions have high concentration of ch ... Full text Link to item Cite

Synthesis of photo-responsive single-stranded DNA micelles via copper-free click chemistry

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 10, 2014 Link to item Cite

Enzymatic polymerization of high molecular weight DNA amphiphiles that self-assemble into star-like micelles.

Journal Article Advanced materials (Deerfield Beach, Fla.) · May 2014 High molecular weight ssDNA amphiphiles are synthesized by enzymatic polymerization. These highly asymmetric diblock DNA copolymers self-assemble into "hairy", star-like micelles, shown in the AFM image and the DPD snapshot. ... Full text Cite

Handbook of Nanomaterials Properties

Book · March 13, 2014 This Handbook of Nanomaterials Properties will be the first single reference work that brings together the various properties with wide breadth and scope. ... Cite

"Smart" DNA interfaces.

Journal Article Chemical Society reviews · March 2014 This review focuses on surface-grafted DNA, and its use as a molecular building block that exploits its unique properties as a directional (poly)anion that exhibits molecular recognition. The selected examples highlight innovative applications of DNA at su ... Full text Cite

Interaction of lubricin with type II collagen surfaces: adsorption, friction, and normal forces.

Journal Article Journal of biomechanics · February 2014 One of the major constituents of the synovial fluid that is thought to be responsible for chondroprotection and boundary lubrication is the glycoprotein lubricin (PRG4); however, the molecular mechanisms by which lubricin carries out its critical functions ... Full text Cite

Micromechanical mapping of early osteoarthritic changes in the pericellular matrix of human articular cartilage.

Journal Article Osteoarthritis and cartilage · December 2013 ObjectiveOsteoarthritis (OA) is a degenerative joint disease characterized by the progressive loss of articular cartilage. While macroscale degradation of the cartilage extracellular matrix (ECM) has been extensively studied, microscale changes in ... Full text Cite

Model cell membranes: Techniques to form complex biomimetic supported lipid bilayers via vesicle fusion.

Journal Article Current opinion in colloid & interface science · October 2013 Vesicle fusion has long provided an easy and reliable method to form supported lipid bilayers (SLBs) from simple, zwitterionic vesicles on siliceous substrates. However, for complex compositions, such as vesicles with high cholesterol content and multiple ... Full text Cite

Colloids and surfaces in biology

Journal Article Current Opinion in Colloid and Interface Science · October 1, 2013 Full text Cite

Enzyme catalyzed polymerization of DNA amphiphiles that self-assemble into star-like micelles

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · September 8, 2013 Link to item Cite

Programming smart macromolecular and ferroelectric surfaces for (bio)sensing applications

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · April 7, 2013 Link to item Cite

Electric double layer formed by polarized ferroelectric thin films.

Journal Article ACS applied materials & interfaces · April 2013 Ferroelectric surfaces can have very high surface charge densities that can be harnessed for manipulation of charged colloidal particles and soft matter in aqueous environments. Here, we report on the electrical double layer (EDL) formed by polarized ultra ... Full text Cite

Side effects suspected to be related to doxycycline use in cats.

Journal Article The Veterinary record · February 2013 Full text Cite

Decoupling mass adsorption from fluid viscosity and density in quartz crystal microbalance measurements using normalized conductance modeling

Journal Article Measurement Science and Technology · January 1, 2013 We describe the physical understanding of a method which differentiates between the frequency shift caused by fluid viscosity and density from that caused by mass adsorption in the resonance of a quartz crystal resonator. This method uses the normalized co ... Full text Cite

Biomimetic supported lipid bilayers with high cholesterol content formed by α-helical peptide-induced vesicle fusion.

Journal Article Journal of materials chemistry · August 2012 In this study, we present a technique to create a complex, high cholesterol-containing supported lipid bilayers (SLBs) using α-helical (AH) peptide-induced vesicle fusion. Vesicles consisting of POPC : POPE : POPS : SM : Chol (9.35 : 19.25 : 8.25 : 18.15 : ... Full text Cite

Electric field-induced nanolithography to manipulate soft matter on surfaces

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · March 25, 2012 Link to item Cite

Screening the interactions between HIV-1 neutralizing antibodies and model lipid surfaces.

Journal Article J Immunol Methods · February 28, 2012 Our work is motivated by the observation that rare, broadly neutralizing antibodies (NAbs), 4E10 and 2F5, associate with HIV-1 lipids as part of a required first step in neutralization before binding to membrane-proximal antigens. Subsequently, induction o ... Full text Link to item Cite

Manipulating the motion of gold aggregates using stimulus-responsive patterned polymer brushes as a motor

Journal Article Advanced Functional Materials · January 25, 2012 An important goal and major challenge of material science and nanotechnology is building nanomotors for manipulating the motion of nanoparticles (NPs). Here, it is demonstrated that patterned, stimulus-responsive polymer brush microstructures can be used a ... Full text Cite

Altered trabecular bone structure and delayed cartilage degeneration in the knees of collagen VI null mice.

Journal Article PloS one · January 2012 Mutation or loss of collagen VI has been linked to a variety of musculoskeletal abnormalities, particularly muscular dystrophies, tissue ossification and/or fibrosis, and hip osteoarthritis. However, the role of collagen VI in bone and cartilage structure ... Full text Open Access Cite

Mapping mechanical properties of organic thin films by force-modulation microscopy in aqueous media.

Journal Article Beilstein J Nanotechnol · 2012 The mechanical properties of organic and biomolecular thin films on surfaces play an important role in a broad range of applications. Although force-modulation microscopy (FMM) is used to map the apparent elastic properties of such films with high lateral ... Full text Link to item Cite

Ferroelectric thin films in fluidic environments: a new interface for sensing and manipulation of matter.

Journal Article Small (Weinheim an der Bergstrasse, Germany) · January 2012 For decades ferroelectric thin films (FETFs) have been the focus of research and development for next-generation memory and semiconductor devices. FETFs are attractive because their polarization states are highly localized, stable, and switchable. These un ... Full text Cite

Colloidal lithography for fabricating patterned polymer-brush microstructures.

Journal Article Beilstein journal of nanotechnology · January 2012 We exploit a series of robust, but simple and convenient colloidal lithography (CL) approaches, using a microsphere array as a mask or as a guiding template, and combine this with surface-initiated atom-transfer radical polymerization (SI-ATRP) to fabricat ... Full text Cite

Field-induced nanolithography for the patterning of non-fouling polymer brushes

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · 2012 Cite

Molecular mechanisms of aqueous boundary lubrication by mucinous glycoproteins

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · 2012 Cite

Field-induced nanolithography for patterning of non-fouling polymer brush surfaces.

Journal Article Small (Weinheim an der Bergstrasse, Germany) · November 2011 Full text Cite

Dynamic microcontact printing for patterning polymer-brush microstructures.

Journal Article Small (Weinheim an der Bergstrasse, Germany) · August 2011 Full text Cite

Polymer brush patterning using self-assembled microsphere monolayers as microcontact printing stamps

Journal Article Soft Matter · June 21, 2011 Self-assembled microsphere monolayers (SMMs) hold significant promise for micro- and nanopatterning. Here we exploit, for the first time, SMMs as stamps for microcontact printing (μCP) and demonstrate this to fabricate patterned initiator templates that ca ... Full text Cite

Extending micro-contact printing for patterning complex polymer brush microstructures

Journal Article Polymer · May 26, 2011 As a fast developing soft lithographic technique, the development of micro-contact printing (μCP) has exceeded the original aim of replicating poly(dimethylsiloxane) (PDMS) stamp patterns. Here we exploited several extended μCP strategies with various prin ... Full text Cite

Imaginary magnetic tweezers for massively parallel surface adhesion spectroscopy.

Journal Article Nano letters · April 2011 A massively parallel magnetic tweezer system has been constructed that utilizes the self-repulsion of colloidal beads from a planar interface via a magnetic dipole image force. Self-repulsion enables the application of a uniform magnetic force to thousands ... Full text Cite

Molecular mechanisms of aqueous boundary lubrication by mucinous glycoproteins

Journal Article Current Opinion in Colloid and Interface Science · December 1, 2010 Mucins have long been recognized as instrumental to biolubrication but the molecular details of their lubrication mechanisms have only been explored relatively recently. The glycoprotein PRG4, also known as lubricin, shares many features with mucins and ap ... Full text Cite

Colloids and surfaces in biology

Journal Article Current Opinion in Colloid and Interface Science · December 1, 2010 Full text Cite

Development of an adaptive vapor chamber with thermoresponsive polymer coating

Journal Article Proceedings of the ASME Micro/Nanoscale Heat and Mass Transfer International Conference 2009, MNHMT2009 · July 12, 2010 We propose a novel concept for an adaptive vapor chamber using a thermoresponsive polymer coating to enhance heat transfer and reduce local thermal gradients. By coating the wick structures with stimulus-responsive polymer brushes with an upper critical so ... Full text Cite

Spatial mapping of the biomechanical properties of the pericellular matrix of articular cartilage measured in situ via atomic force microscopy.

Journal Article Biophys J · June 16, 2010 In articular cartilage, chondrocytes are surrounded by a narrow region called the pericellular matrix (PCM), which is biochemically, structurally, and mechanically distinct from the bulk extracellular matrix (ECM). Although multiple techniques have been us ... Full text Link to item Cite

Glucose-responsive polymer brushes for microcantilever sensing

Journal Article Journal of Materials Chemistry · June 8, 2010 Glucose responsive polymer brushes were synthesized on gold substrates and microcantilever arrays. The response properties of these brushes were evaluated by exposing them to different glucose concentrations for a range of pH values. This work demonstrates ... Full text Open Access Cite

Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4.

Journal Article Arthritis and rheumatism · June 2010 ObjectiveTo assess the role of the glycoprotein PRG4 in joint lubrication and chondroprotection by measuring friction, stiffness, surface topography, and subsurface histology of the hip joints of Prg4(-/-) and wild-type (WT) mice.MethodsF ... Full text Open Access Cite

Peptide interfacial biomaterials improve endothelial cell adhesion and spreading on synthetic polyglycolic acid materials.

Journal Article Ann Biomed Eng · June 2010 Resorbable scaffolds such as polyglycolic acid (PGA) are employed in a number of clinical and tissue engineering applications owing to their desirable property of allowing remodeling to form native tissue over time. However, native PGA does not promote end ... Full text Open Access Link to item Cite

Emerging applications of stimuli-responsive polymer materials.

Journal Article Nature materials · February 2010 Responsive polymer materials can adapt to surrounding environments, regulate transport of ions and molecules, change wettability and adhesion of different species on external stimuli, or convert chemical and biochemical signals into optical, electrical, th ... Full text Cite

Stimulus-responsive polymer brushes on surfaces: Transduction mechanisms and applications

Journal Article PROGRESS IN POLYMER SCIENCE · January 2010 Stimulus-responsive polymer brushes (SRPBs) exhibit a change in conformation and structure, often accompanied by a noticeable change in surface energy, due to an external stimulus such as a change in solvent composition, temperature, pH, ionic strength, li ... Full text Cite

The inhomogeneous mechanical properties of the pericellular matrix of articular cartilage measured in situ by atomic force microscopy

Journal Article Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009 · December 1, 2009 Full text Cite

Friction Force Microscopy of Lubricin and Hyaluronic Acid between Hydrophobic and Hydrophilic Surfaces.

Journal Article Soft matter · September 2009 Lubricin and hyaluronic acid (HA), molecular constituents of synovial fluid, have long been theorized to play a role in joint lubrication and wear protection. While lubricin has been shown to function as a boundary lubricant, conflicting evidence exists as ... Full text Cite

Mechanical properties and gene expression of chondrocytes on micropatterned substrates following dedifferentiation in monolayer.

Journal Article Cellular and molecular bioengineering · August 2009 Chondrocytes in articular cartilage normally exhibit high expression of collagen II and aggrecan but rapidly dedifferentiate to a fibroblastic phenotype if passaged in culture. Previous studies have suggested that the loss of chondrocyte phenotype is assoc ... Full text Cite

Versatile synthesis and micropatterning of nonfouling polymer brushes on the wafer scale.

Journal Article Biointerphases · June 2009 In this article, the authors describe new approaches to synthesize and pattern surfaces with poly[oligo(ethylene glycol) methyl methacrylate] (POEGMA) polymer brushes synthesized by surface-initiated atom transfer radical polymerization. These patterned co ... Full text Cite

Biological applications of polymer brushes. Preface.

Journal Article Biointerphases · June 2009 Full text Cite

Fabrication of Micropatterned Stimulus-Responsive Polymer-Brush 'Anemone'

Journal Article Advanced Materials · May 2009 A simple strategy to fabricate stimulus-responsive patterned PNIPAAM-brush microstructures ('anemones') is presented. The size of the microstructures can be adjusted by setting the composition of thiol and the contact pressure. We demonstrate that the patt ... Cite

Responsive polymer brush nanosponges

Journal Article ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · March 22, 2009 Link to item Cite

Fabrication of novel polymer brush microstructures using microcontact printing as a tool

Journal Article ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · March 22, 2009 Link to item Cite

Computational modeling of surface phenomena in soft-wet materials

Journal Article International Journal of Solids and Structures · March 15, 2009 We consider the problem of extracting tribological information from experimental observations of contact with soft-wet materials. Particular attention is placed on simulating the response of two rotating cylinders of soft specimens placed in frictional con ... Full text Cite

Separation of Peptides with Polyionic Nanosponges for MALDI-MS Analysis

Journal Article Langmuir · February 2009 A polymer brush consisting of 70\% poly(N-isopropylacrylamide) (PNIPAAM) and 30\% polymethacrylic acid (PMAA) was synthesized from gold substrates with a "grafting from" AIBN-type free-radical initiator. Fractionation of two peptides, bradykinin and buccal ... Cite

Quantitative biological surface science: challenges and recent advances.

Journal Article ACS nano · December 2008 Biological surface science is a broad, interdisciplinary subfield of surface science, where properties and processes at biological and synthetic surfaces and interfaces are investigated, and where biofunctional surfaces are fabricated. The need to study an ... Full text Cite

Effect of shockwaves on the biomechanical and biochemical function of cells

Journal Article Society for Experimental Mechanics - 11th International Congress and Exhibition on Experimental and Applied Mechanics 2008 · December 1, 2008 The number of non-lethal cases of soldiers being exposed to blasts from improvised explosive devices (IED) has increased significantly over the last few years. Concurrently, the number of soft tissue injuries, including traumatic brain injuries (TBI) and h ... Cite

Hydration and conformational mechanics of single, end-tethered elastin-like polypeptides

Journal Article Journal of the American Chemical Society · August 20, 2008 We investigated the effect of temperature, ionic strength, solvent polarity, and type of guest residue on the force-extension behavior of single, end-tethered elastin-like polypeptides (ELPs), using single molecule force spectroscopy (SMFS). ELPs are stimu ... Full text Cite

Distance-dependent plasmon resonant coupling between a gold nanoparticle and gold film.

Journal Article Nano letters · August 2008 We present an experimental analysis of the plasmonic scattering properties of gold nanoparticles controllably placed nanometers away from a gold metal film. We show that the spectral response of this system results from the interplay between the localized ... Full text Cite

Bimaterial microcantilevers as a hybrid sensing platform

Journal Article Advanced Materials · February 18, 2008 Microcantilevers, one of the most common MEMS structures, have been introduced as a novel sensing paradigm nearly a decade ago. Ever since, the technology has emerged to find important applications in chemical, biological and physical sensing areas. Today ... Full text Cite

Conformational mechanics, adsorption, and normal force interactions of lubricin and hyaluronic acid on model surfaces.

Journal Article Langmuir : the ACS journal of surfaces and colloids · February 2008 Glycoproteins, such as lubricin, and hyaluronic acid (HA) play a prominent role in the boundary lubrication mechanism in diarthrodial joints. Although many studies have tried to elucidate the lubrication mechanisms of articular cartilage, the molecular det ... Full text Cite

Novel evaluation method of neutron reflectivity data applied to stimulus-responsive polymer brushes

Journal Article Soft Matter · 2008 Neutron reflectivity (NR) measurements have been performed on stimulus-responsive polymer brushes containing N-isopropylacrylamide (NIPAAM) at different temperatures and contrasts using two different brush samples of roughly the same grafting density and l ... Cite

Viscoelastic properties of human mesenchymally-derived stem cells and primary osteoblasts, chondrocytes, and adipocytes.

Journal Article Journal of biomechanics · January 2008 The mechanical properties of single cells play important roles in regulating cell-matrix interactions, potentially influencing the process of mechanotransduction. Recent studies also suggest that cellular mechanical properties may provide novel biological ... Full text Cite

Polymeric and biomacromolecular brush nanostructures: progress in synthesis, patterning and characterization

Journal Article Soft Matter · 2008 A significant scientific and engineering challenge of recent years has been the fabrication of patterned polymeric and biomacromolecular brush nanostructures on surfaces. These structures provide researchers with a rich platform on which to exploit and obs ... Cite

In situ friction measurement on murine cartilage by atomic force microscopy.

Journal Article Journal of biomechanics · January 2008 Articular cartilage provides a low-friction, wear-resistant surface for the motion of diarthrodial joints. The objective of this study was to develop a method for in situ friction measurement of murine cartilage using a colloidal probe attached to the cant ... Full text Cite

Single molecule nanomechanics of HIV-1 envelope glycoproteins and elastin-like polypeptides

Journal Article Proceedings of the SEM Annual Conference and Exposition on Experimental and Applied Mechanics 2007 · November 19, 2007 Cite

POLY 627-Fabrication of bioconjugated and hybrid polymeric nanostructures by field-induced scanning probe lithography

Journal Article ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 19, 2007 Link to item Cite

Force-induced prolyl cis-trans isomerization in elastin-like polypeptides.

Journal Article J Am Chem Soc · May 23, 2007 Elastin-like polypeptides (ELPs) are stimulus-responsive polymers that contain repeats of five amino acids, Val-Pro-Gly-Xaa-Gly (VPGXG), where Xaa is a guest residue that can be any amino acid with the exception of proline. While studying the conformationa ... Full text Link to item Cite

A thin-layer model for viscoelastic, stress-relaxation testing of cells using atomic force microscopy: do cell properties reflect metastatic potential?

Journal Article Biophysical journal · March 2007 Atomic force microscopy has rapidly become a valuable tool for quantifying the biophysical properties of single cells. The interpretation of atomic force microscopy-based indentation tests, however, is highly dependent on the use of an appropriate theoreti ... Full text Cite

Switchable friction of stimulus-responsive hydrogels.

Journal Article Langmuir : the ACS journal of surfaces and colloids · January 2007 Poly(N-isopropylacrylamide) (pNIPAAm) gels are stimulus-responsive hydrogels that exhibit large reversible changes in their volume and surface physicochemical properties near the lower critical solution temperature (LCST) in response to external stimuli, s ... Full text Cite

Scaling behavior of nanopatterned polymer brushes.

Journal Article Small (Weinheim an der Bergstrasse, Germany) · January 2007 Full text Cite

Microcantilever sensing and actuation with end-grafted stimulus-responsive elastin-like polypeptides.

Journal Article Langmuir : the ACS journal of surfaces and colloids · January 2007 Stimulus-responsive elastin-like polypeptides (ELPs) grafted onto surfaces are of significant technical interest because they can be exploited for force generation, in sensing applications, or as molecular switches with tunable properties. Changes in the c ... Full text Cite

Using microcantilever deflection to detect HIV-1 envelope glycoprotein gp120.

Journal Article Nanomedicine · December 2006 Microcantilevers have been used over the last decade to detect biomolecules from solution. Specific binding events on one surface of the microcantilever create a differential stress, resulting in measurable deflection. Here we use this principle to detect ... Full text Link to item Cite

Reversibly cross-linked surface-grafted polymer brushes.

Journal Article Angewandte Chemie (International ed. in English) · November 2006 Full text Cite

POLY 101-Switchable friction of stimulus-responsive hydrogels

Journal Article ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · September 10, 2006 Link to item Cite

Weak polyelectrolyte brush arrays fabricated by combining electron-beam lithography with surface-initiated photopolymerization

Journal Article Chemistry of Materials · August 8, 2006 We present a simple "top-down/bottom-up" strategy to fabricate nano- and micropatterned polymer brush arrays composed of pH- and salt-sensitive, weak polyelectrolyte copolymers [poly(N-isopropy-lacrylamide-co- methacrylic acid, 3:1, poly (NIPAAM-co-MAA)]. ... Full text Cite

Friction reducing properties of lubricin (PRG4): A nanoscale study of chondroprotection

Journal Article European Cells and Materials · August 1, 2006 Cite

Peptide-PEG amphiphiles as cytophobic coatings for mammalian and bacterial cells.

Journal Article Chemistry & biology · July 2006 Amphiphilic macromolecules containing a polystyrene-adherent peptide domain and a cell-repellent poly(ethylene glycol) domain were designed, synthesized, and evaluated as a cytophobic surface coating. Such cytophobic, or cell-repellent, coatings are of int ... Full text Cite

Viscoelastic properties of zonal articular chondrocytes measured by atomic force microscopy.

Journal Article Osteoarthritis and cartilage · June 2006 ObjectiveArticular chondrocytes respond to chemical and mechanical signals depending on their zone of origin with respect to distance from the tissue surface. However, little is known of the zonal variations in cellular mechanical properties in ca ... Full text Cite

Fabrication of micropatterned gold nanoparticle arrays as a template for surface-initiated polymerization of stimuli-responsive polymers

Journal Article Macromolecular Rapid Communications · May 19, 2006 This paper demonstrates a new, reliable, and simple method for fabricating micropatterned nanoparticle arrays that can serve as templates for the surface-initiated polymerization of polymer brushes. As a proof of concept, we micropatterned gold nanoparticl ... Full text Cite

Understanding the elasticity of fibronectin fibrils: unfolding strengths of FN-III and GFP domains measured by single molecule force spectroscopy.

Journal Article Matrix Biol · April 2006 While it is well established that fibronectin (FN) matrix fibrils are elastic, the mechanism of fibril elasticity during extension is still debated. To investigate the molecular origin of FN fibril elasticity, we used single molecule force spectroscopy (SM ... Full text Link to item Cite

Micro-cantilevers with end-grafted stimulus-responsive polymer brushes for actuation and sensing

Journal Article Sensors and Actuators, B: Chemical · March 30, 2006 Stimulus-responsive macromolecules have attracted significant interest due to their potential applications in molecular motors, drug delivery, sensors, and actuation devices. Poly(N-isopropylacrylamide) (pNIPAAM) alone or as a copolymer is a stimulus-respo ... Full text Cite

Adhesion interactions between poly(vinyl alcohol) and iron-oxide surfaces: The effect of acetylation

Journal Article Journal of Applied Polymer Science · February 15, 2006 Atomic force microscopy with chemically functionalized colloidal probes was used to study "acid-base" interactions between poly(vinyl alcohol) (PVA) and a metal surface. By using well-defined model surfaces, we have studied the adhesion forces between a hy ... Full text Cite

Chemical force microscopy of cellulosic fibers

Journal Article Carbohydrate Polymers · December 14, 2005 Atomic force microscopy with chemically modified cantilever tips (chemical force microscopy) was used to study the pull-off forces (adhesion forces) on cellulose model surfaces and bleached softwood kraft pulp fibers in aqueous media. It was found that for ... Full text Cite

Enzymatic fabrication of DNA nanostructures: extension of a self-assembled oligonucleotide monolayer on gold arrays.

Journal Article Journal of the American Chemical Society · October 2005 Nucleic acid nanostructures are useful as templates for bionanofabrication of composite molecular nanostructures in materials science, molecular electronics, and biosensing. Here, we demonstrate that terminal deoxynucleotidyl transferase, which repetitivel ... Full text Cite

Stimulus-responsive elastin-like polypetides as coatings for microcantilevers: Applications for sensing and actuation

Journal Article ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 28, 2005 Link to item Cite

Rapid fabrication of DNA nanostructures by enzymatic reactions

Journal Article ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 28, 2005 Link to item Cite

Atomic force microscopy study of reversibly crosslinked polymer brushes

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 28, 2005 Link to item Cite

Progress in fabrication and characterization of nanopatterned polymer brushes

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 28, 2005 Link to item Cite

pH, salt, and solvent sensitive polymer brush micro- and nanopatterns fabricated by electron-beam lithography

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 28, 2005 Link to item Cite

Nanofabrication with biomolecules

Journal Article Materials Today · January 1, 2005 The advances made in biotechnology and nanotechnology for building complex bionanostructures on surfaces with nanometer precision are discussed. The use of biomolecules for nanoscale has become an effective solution for difficult positioning problems in th ... Full text Cite

Self-assembly and properties of main-chain reversible polymer brushes

Journal Article Advanced Materials · 2005 The compressive and adhesive mechanical properties of self-assembled polymer brushes were investigated using DNA-based modules. The effects of surface anchor density, association strength, and monomer flexibility on the properties were also investigated. R ... Full text Link to item Cite

Polypeptide-solvent interactions measured by single molecule force spectroscopy

Journal Article Materials Research Society Symposium Proceedings · 2005 Stimulus-responsive biomolecules have attracted a large research interest because of their potential application in various areas such as drug delivery, actuators and sensing devices at the nanoscale. Using single-molecule force spectroscopy (SMFS) we stud ... Cite

Mechanics of stimulus-responsive elastin-like polypeptides studied by force spectroscopy.

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 22, 2004 Link to item Cite

Capture and release of proteins on the nanoscale by stimuli-responsive elastin-like polypeptide "switches".

Journal Article Journal of the American Chemical Society · June 2004 This article describes the fabrication and characterization of stimulus-responsive elastin-like polypeptide (ELP) nanostructures grafted onto omega-substituted thiolates that were patterned onto gold surfaces by dip-pen nanolithography (DPN). In response t ... Full text Cite

Investigation of nanoscale friction in poly(N-isopropylacrylamide) brushes by atomic force microscopy.

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · March 28, 2004 Link to item Cite

Preparation and characterization of stimulus-responsive poly(N-isopropyl-acrylamide) brushes and nanopatterns.

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · March 28, 2004 Link to item Cite

Fabrication of Stimulus-Responsive Nanopatterned Polymer Brushes by Scanning-Probe Lithography

Journal Article Nano Letters · February 1, 2004 Stimulus-responsive, surface confined poly(N-isopropylacrylamide) (pNIPAAM) brush nanopatterns were prepared on gold-coated silicon substrates in a "grafting-from" approach that combines "nanoshaving", a scanning probe lithography method, with surface-init ... Full text Cite

Surface-initiated polymerization on nanopatterns fabricated by electron-beam lithography

Journal Article Advanced Materials · 2004 A new 'top-down/bottom-up' approach for fabricating patterned polymer-brush arrays on the micrometer and nanometer length scales was reported. It was suggested that patterns with well-defined feature dimensions, shapes, and inter-feature spacings can be ea ... Full text Link to item Cite

Stimulus-responsive poly(N-isopropylacrylamide) brushes and nanopatterns prepared by surface-initiated polymerization

Journal Article Chemistry of Materials · 2004 In this paper we report the surface-initiated polymerization of poly(N-isopropylacrylamide) (pNIPAAM), a stimulus-responsive polymer, from monolayers of ω-mercaptoundecyl bromoisobutyrate on gold-coated surfaces. pNIPAAM was polymerized in aqueous so ... Full text Link to item Cite

Conformational Mechanics of Stimulus-Responsive Polypeptides

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · November 27, 2003 Stimulus-responsive polymers and polypeptides (SRPs) experience a significant entropic response when exposed to an environmental stimulus, such as a change in temperature. This phase transition directly affects polymer conformation and can potentially be h ... Full text Cite

Force interactions between calcium carbonate and chemically functionalized colloidal probes: The effect of calcium ion and polyelectrolyte addition

Journal Article International Paper and Coating Chemistry Symposium, Proceedings · November 20, 2003 An understanding of fundamental interactions of micron-sized pigments in papermaking and paper coating processes is important in controlling the interactions between the pigment and cellulose fibers, flocculants and binder. This research established, for t ... Cite

Fabrication of "smart" protein nanostructures using molecular recognition and dip-pen nano-lithography.

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · September 1, 2003 Link to item Cite

Fabrication of stimulus-responsive polymeric nanostructures by proximal probes

Journal Article Materials Research Society Symposium - Proceedings · July 28, 2003 The triggered control of interfacial properties on the nanometer scale holds significant promise for actuation in bio-nanotechnology applications where polymeric actuators may manipulate the transport, separation, and detection of biomolecules. To fabricat ... Cite

Fabrication of surface confined, stimulus-responsive polymer nanostructures using dip-pen nanolithography.

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · March 1, 2003 Link to item Cite

Surface forces and friction between cellulose surfaces in aqueous media

Conference NANOTRIBOLOGY: CRITICAL ASSESSMENT AND RESEARCH NEEDS · 2003 Cite

The influence of fatty acids and humidity on friction and adhesion of hydrophilic polymer surfaces

Journal Article Langmuir · September 3, 2002 Monolayers of saturated fatty acids of different chain lengths and of 9-cis-octadecenoic acid were physisorbed onto regenerated cellulose surfaces to study their effect on friction and adhesion. Lateral and normal force measurements on these surfaces were ... Full text Cite

The influence of fatty acids and humidity on the friction of hydrophilic polymer surfaces.

Journal Article ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · April 7, 2002 Link to item Cite

Molecular recognition-mediated fabrication of protein nanostructures by dip-pen lithography

Journal Article Nano Lett. (USA) · 2002 We describe the molecular recognition-mediated, stepwise fabrication of patterned protein nanostructures with feature sizes on the order of 200 nm. First, a self-assembled monolayer (SAM) of 16-mercaplohexadecanoic acid (MHA) is patterned onto gold by dip- ... Full text Link to item Cite

Determination of adhesion forces between adhesives and metal/paper surfaces using atomic force microscopy.

Journal Article ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · 2002 Cite

Friction of hydrogel surfaces.

Journal Article ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · April 1, 2001 Link to item Cite

Friction between cellulose surfaces measured with colloidal probe microscopy

Journal Article Colloids and Surfaces A: Physicochemical and Engineering Aspects · March 15, 2001 Colloidal probe microscopy was employed to study sliding friction between model cellulose surfaces in aqueous solutions. Regardless of scan size, friction exhibits irregular stick-slip behavior related to surface roughness. At small scan sizes (∼10 nm), th ... Full text Cite

Pulp extrusions incorporating sludge from the pulp and paper industry

Journal Article TAPPI Proceedings - Environmental Conference and Exhibit · December 1, 2000 Pulp extrusion at ultra-high consistency (≅30% solids) has been shown to be a viable process for converting recovered paper, wastepaper, and papermill residues into solid sheets and profiles. We have previously shown that extrusion of ultra-high consistenc ... Cite

Normal Forces between Cellulose Surfaces Measured with Colloidal Probe Microscopy.

Journal Article Journal of colloid and interface science · September 2000 Colloidal probe microscopy was employed to study interactions between cellulose surfaces in aqueous solutions. Hydrodynamic forces must be accounted for in data analysis. Long-range interactions betweeen cellulose surfaces are governed by double-layer forc ... Full text Cite

Surface and friction forces between cellulose surfaces measured with colloidal probe microscopy

Journal Article Nordic Pulp and Paper Research Journal · January 1, 2000 To better understand interactions that govern the micro-rheological behavior of pulp fiber suspensions, we used colloidal probe microscopy to study normal forces and sliding friction between model cellulose surfaces in polyelectrolyte solutions. Hydrodynam ... Full text Cite

Pulp extrusion for recycling wastepapers and paper mill sludges

Journal Article TAPPI Journal · January 1, 2000 Extrusion processing offers a new method by which pulps from recycled papers and sludges can be processed at ultra-high consistencies to form useful products. However, the method must surmount two problems. First, the fiber suspension must be made to flow ... Cite

Pulp extrusion at ultra-high consistencies: a new processing method for recycling waste papers and papermill sludges

Conference FIFTH INTERNATIONAL CONFERENCE ON WOODFIBER-PLASTIC COMPOSITES · 1999 Cite

Rheology and extrusion of low-grade paper and sludge

Conference TAPPI INTERNATIONAL ENVIRONMENTAL CONFERENCE, VOLS 1-3 · 1999 Cite

Force imaging cellulose with colloidal probe microscopy.

Journal Article ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · 1998 Cite

Orienting lignocellulosic fibers and particles by means of a magnetic field

Journal Article Wood and Fiber Science · December 1, 1997 Fiber and particle alignment in composite materials may be used to tailor material and object properties to specific performance requirements. The present research demonstrates that alignment of ferromagnetically modified slender wood particles in magnetic ... Cite

Pulp extrusion at ultra-high consistencies

Journal Article TAPPI Proceedings - Environmental Conference & Exhibition · December 1, 1997 A new process for producing continuous lignocellulosic fiber products is currently under development at the USDA Forest Service, Forest Products Laboratory. The goal of this exploratory research is to utilize conventional pulping techniques to process reco ... Cite

Influence of water on the elastic modulus of paper

Journal Article TAPPI Journal · 1997 In Part I, an extension of the theory of hydrogen-bond-dominated solids was proposed. In Part 2, the predictions of the extended theory are tested statistically using recently reported measurements of elastic moduli for 24 papers over a wide range of moist ... Cite

Influence of water on the elastic modulus of paper part 2:Verification of predictions of the H-bond theory

Journal Article Tappi Journal · January 1, 1997 In Part I, an extension of the theory of hydrogen-bond-dominated solids was proposed. In Part 2, the predictions of the extended theory are tested statistically using recently reported measurements of elastic moduli for 24 papers over a wide range of moist ... Cite

Pulp extrusion: A new processing method for recycling recovered wastepaper and papermill sludge and its application for building materials

Journal Article Proceedings of the Conference on the Use of Recycled Wood and Paper in Building Applications · December 1, 1996 Fibers recovered from recycled paper products have desirable mechanical properties and can be used for the manufacture of composite materials. Contrary to their use in papermaking, recycled wood pulp fibers used for composites may require only minimal clea ... Cite

The influence of water on the elastic modulus of paper. Part I: Extension of the H-bond theory

Journal Article Tappi Journal · December 1, 1996 In Part I, the theory of hydrogen-bond-dominated solids is extended to explain phenomena concerning the elastic behavior of paper, based on the postulate that the number dencity of effective hydrogen bonds, normalized to on average bond stiffness, is highe ... Cite

Rheology and extrusion processability of pulp suspensions

Journal Article Proceedings of the Conference on the Use of Recycled Wood and Paper in Building Applications · December 1, 1996 The mechanism by which water-soluble polymers change suspension rheology is examined. The effect of polymer addition on rheology was evaluated using a torque rheometer where large shear rates and strains prevail. The polymer addition level for sufficient f ... Cite