Scholars@Duke
Christopher G. Willett

Christopher G. Willett

Chair, Department of Radiation Oncology
Radiation Oncology
christopher.willett@duke.edu
Box 3085 Med Ctr, Durham, NC
Morris Bldg, Durham, NC

Selected Publications

NCCN Guidelines® Insights: Rectal Cancer, Version 3.2024.

Journal Article J Natl Compr Canc Netw · August 2024 The determination of an optimal treatment plan for an individual patient with rectal cancer is a complex process. In addition to decisions relating to the intent of rectal cancer surgery (ie, curative or palliative), consideration must also be given to the ... Full text Link to item Cite

Colon Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · June 2024 Colorectal cancer (CRC) is the fourth most frequently diagnosed cancer and the second leading cause of cancer death in the United States. Management of disseminated metastatic CRC involves various active drugs, either in combination or as single agents. Th ... Full text Link to item Cite

Neoadjuvant Short- Vs. Long-Course Radiation for Locally Advanced Rectal Cancer: How to Choose.

Journal Article Curr Treat Options Oncol · April 2024 Over the past decades, the treatment of locally advanced rectal cancer has evolved dramatically due to improvements in diagnostic imaging, surgical technique, and the addition of radiotherapy and/or chemotherapy. Fractionation of neoadjuvant radiotherapy w ... Full text Link to item Cite

The Society of Thoracic Surgeons/American Society for Radiation Oncology Updated Clinical Practice Guidelines on Multimodality Therapy for Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction.

Journal Article Ann Thorac Surg · January 2024 Outcomes for patients with esophageal cancer have improved over the last decade with the implementation of multimodality therapy. There are currently no comprehensive guidelines addressing multidisciplinary management of esophageal cancer that have incorpo ... Full text Link to item Cite

The Society of Thoracic Surgeons/American Society for Radiation Oncology Updated Clinical Practice Guidelines on Multimodality Therapy for Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction.

Journal Article Pract Radiat Oncol · 2024 Outcomes for patients with esophageal cancer have improved over the last decade with the implementation of multimodality therapy. There are currently no comprehensive guidelines addressing multidisciplinary management of esophageal cancer that have incorpo ... Full text Link to item Cite

Management of Metastic Liver Cancer

Chapter · January 1, 2024 The liver is the most common site for blood-borne metastasis from colorectal cancers, and is the dominant metastatic disease site just prior to death (Stewart et al. 2018). Until the early 1980s, it was generally accepted that hepatic metastases from color ... Full text Cite

Radiation Therapy

Chapter · January 1, 2024 Cite

Anal Carcinoma, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · June 2023 This discussion summarizes the NCCN Clinical Practice Guidelines for managing squamous cell anal carcinoma, which represents the most common histologic form of the disease. A multidisciplinary approach including physicians from gastroenterology, medical on ... Full text Link to item Cite

Esophageal and Esophagogastric Junction Cancers, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology.

Journal Article Journal of the National Comprehensive Cancer Network : JNCCN · April 2023 Cancers originating in the esophagus or esophagogastric junction constitute a major global health problem. Esophageal cancers are histologically classified as squamous cell carcinoma (SCC) or adenocarcinoma, which differ in their etiology, pathology, tumor ... Full text Cite

Rectal Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.

Journal Article Journal of the National Comprehensive Cancer Network : JNCCN · October 2022 This selection from the NCCN Guidelines for Rectal Cancer focuses on management of malignant polyps and resectable nonmetastatic rectal cancer because important updates have been made to these guidelines. These recent updates include redrawing the algorith ... Full text Cite

Gastric Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · February 2022 Gastric cancer is the third leading cause of cancer-related deaths worldwide. Over 95% of gastric cancers are adenocarcinomas, which are typically classified based on anatomic location and histologic type. Gastric cancer generally carries a poor prognosis ... Full text Link to item Cite

Transfer learning for fluence map prediction in adrenal stereotactic body radiation therapy.

Conference Phys Med Biol · December 6, 2021 Objective:To design a deep transfer learning framework for modeling fluence map predictions for stereotactic body radiation therapy (SBRT) of adrenal cancer and similar sites that usually have a small number of cases.Approach:We developed a transfer learni ... Full text Link to item Cite

The Role of Hypofractionated Radiation Therapy in the Management of Unresectable Hepatocellular Carcinoma (HCC).

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)Management of HCC without surgical resection or transplantation is poorly defined with no standard. Stereotactic body radiation therapy (SBRT) or hypofractionated image-guided radiotherapy (HIGRT), is an evolving, non-invasive, ... Full text Cite

Toxicity and Dosimetric Parameters of Ablative Radiation Therapy in the Management of Patients with Child-Pugh B/C Liver Function and Unresectable Hepatocellular Carcinoma (HCC).

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)To date there is no clear standard non-surgical therapeutic option for HCC patients. Ablative radiation therapy (SBRT/HIGRT) is an emerging non-invasive treatment for patients with HCC. However, there is concern about the risk ... Full text Cite

Fostering Radiation Oncology Physician Scientist Trainees Within a Diverse Workforce: The Radiation Oncology Research Scholar Track.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2021 There is a need to foster future generations of radiation oncology physician scientists, but the number of radiation oncologists with sufficient education, training, and funding to make transformative discoveries is relatively small. A large number of MD/P ... Full text Open Access Link to item Cite

The role of department chair

Chapter · May 25, 2021 The leadership position of a departmental chair can be a positive and rewarding opportunity. These rewards principally stem from the success of the faculty, trainees, staff, and everyone supporting the department. With healthcare reform and the constraints ... Full text Cite

Treatment of locally advanced/metastatic colorectal cancer

Conference JNCCN Journal of the National Comprehensive Cancer Network · May 1, 2021 Few treatment advances have been observed in recent years for the treatment of advanced colorectal cancer (CRC). The goal remains to find approaches beyond FOLFOX and bevacizumab that will prolong remission. Immunotherapy for patients with microsatellite i ... Full text Cite

An Interpretable Planning Bot for Pancreas Stereotactic Body Radiation Therapy.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2021 PURPOSE: Pancreas stereotactic body radiation therapy (SBRT) treatment planning requires planners to make sequential, time-consuming interactions with the treatment planning system to reach the optimal dose distribution. We sought to develop a reinforcemen ... Full text Link to item Cite

Colon Cancer, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · March 2, 2021 This selection from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Colon Cancer focuses on systemic therapy options for the treatment of metastatic colorectal cancer (mCRC), because important updates have recently been made to this ... Full text Link to item Cite

Deep Learning-Based Fluence Map Prediction for Pancreas Stereotactic Body Radiation Therapy With Simultaneous Integrated Boost.

Journal Article Adv Radiat Oncol · 2021 PURPOSE: Treatment planning for pancreas stereotactic body radiation therapy (SBRT) is a challenging task, especially with simultaneous integrated boost treatment approaches. We propose a deep learning (DL) framework to accurately predict fluence maps from ... Full text Link to item Cite

John Foster Dulles, his medical history and its impact on Cold War politics.

Journal Article J Med Biogr · November 2020 John Foster Dulles was the United States Secretary of State during the administration of President Dwight D Eisenhower. At the height of the Cold War, Dulles was Eisenhower's emissary, traveling over 450,000 international miles, leading United States forei ... Full text Link to item Cite

Treatment of Locally Advanced Esophageal Carcinoma: ASCO Guideline.

Journal Article J Clin Oncol · August 10, 2020 PURPOSE: To develop an evidence-based clinical practice guideline to assist in clinical decision making for patients with locally advanced esophageal cancer. METHODS: ASCO convened an Expert Panel to conduct a systematic review of the more recently publish ... Full text Link to item Cite

Long-term Consequences of Pelvic Irradiation: Toxicities, Challenges, and Therapeutic Opportunities with Pharmacologic Mitigators.

Journal Article Clin Cancer Res · July 1, 2020 A percentage of long-term cancer survivors who receive pelvic irradiation will develop treatment-related late effects, collectively termed pelvic radiation disease. Thus, there is a need to prevent or ameliorate treatment-related late effects in these pati ... Full text Link to item Cite

NCCN Guidelines Insights: Rectal Cancer, Version 6.2020.

Journal Article J Natl Compr Canc Netw · July 2020 The NCCN Guidelines for Rectal Cancer provide recommendations for the diagnosis, evaluation, treatment, and follow-up of patients with rectal cancer. These NCCN Guidelines Insights summarize the panel discussion behind recent important updates to the guide ... Full text Link to item Cite

Trimodal therapy approaches for localized rectal cancer

Conference JNCCN Journal of the National Comprehensive Cancer Network · July 1, 2020 Excellent long-term outcomes and manageable toxicity are being achieved with contemporary treatment strategies for rectal cancer. Short-course radiotherapy is now an acceptable standard. Total neoadjuvant therapy (TNT), which incorporates induction or cons ... Full text Cite

Evaluating treatment protocols for rectal squamous cell carcinomas: the Duke experience and literature.

Journal Article J Gastrointest Oncol · April 2020 BACKGROUND: Colorectal cancer is the third most common cancer in the United States and associated with significant morbidity and mortality. Within colorectal cancer histologies, squamous cell carcinomas (SCC) are rare compared to adenocarcinomas, with only ... Full text Link to item Cite

Results of the NRG Oncology/RTOG 0848 Adjuvant Chemotherapy Question-Erlotinib+Gemcitabine for Resected Cancer of the Pancreatic Head: A Phase II Randomized Clinical Trial.

Journal Article Am J Clin Oncol · March 2020 PURPOSE: NRG/RTOG 0848 was designed to determine whether adjuvant radiation with fluoropyrimidine sensitization improved survival following gemcitabine-based adjuvant chemotherapy for patients with resected pancreatic head adenocarcinoma. In step 1 of this ... Full text Link to item Cite

Multi-Institutional Analysis of Synchronous Prostate and Rectosigmoid Cancers.

Journal Article Front Oncol · 2020 Purpose: To perform a multi-institutional analysis of patients with synchronous prostate and rectosigmoid cancers. Materials and Methods: A retrospective review of Duke University and Durham Veterans Affairs Medical Center records was performed for men wit ... Full text Link to item Cite

Fluence Map Prediction Using Deep Learning Models - Direct Plan Generation for Pancreas Stereotactic Body Radiation Therapy.

Journal Article Front Artif Intell · 2020 Purpose: Treatment planning for pancreas stereotactic body radiation therapy (SBRT) is a difficult and time-consuming task. In this study, we aim to develop a novel deep learning framework to generate clinical-quality plans by direct prediction of fluence ... Full text Open Access Link to item Cite

Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · September 1, 2019 Small bowel adenocarcinoma (SBA) is a rare malignancy of the gastrointestinal tract that has increased in incidence across recent years. Often diagnosed at an advanced stage, outcomes for SBA are worse on average than for other related malignancies, includ ... Full text Link to item Cite

Esophageal and Esophagogastric Junction Cancers, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · July 1, 2019 Esophageal cancer is the sixth leading cause of cancer-related deaths worldwide. Squamous cell carcinoma is the most common histology in Eastern Europe and Asia, and adenocarcinoma is most common in North America and Western Europe. Surgery is a major comp ... Full text Link to item Cite

Role of pelvic chemoradiation therapy in patients with initially metastatic anal canal cancer: A National Cancer Database review.

Journal Article Cancer · June 15, 2019 BACKGROUND: Although the management of localized anal canal squamous cell carcinomas is well established, the role of pelvic chemoradiation (CRT) in the treatment of patients presenting with synchronous metastatic (stage IV) disease is poorly defined. This ... Full text Link to item Cite

NRG Oncology/RTOG 0438: A Phase 1 Trial of Highly Conformal Radiation Therapy for Liver Metastases.

Journal Article Pract Radiat Oncol · 2019 PURPOSE: This study aimed to determine the feasibility and maximally tolerated dose of hypofractionated, conformal radiation therapy (RT) in patients with liver metastases. METHODS AND MATERIALS: Nonsurgical patients with ≤5 liver metastases (sum of maxima ... Full text Link to item Cite

Total Neoadjuvant Therapy (TNT) in Rectal Cancer

Journal Article Current Colorectal Cancer Reports · December 1, 2018 Purpose of Review: This review summarizes the relevant literature on the use of total neoadjuvant therapy (TNT) for patients with locally advanced rectal cancer. It highlights the most notable literature published and briefly discusses future directions. R ... Full text Cite

Cancer of the rectum

Chapter · November 16, 2018 Cite

Cancer of the Colon

Chapter · November 16, 2018 Cite

Association of Interim FDG-PET Imaging During Chemoradiation for Squamous Anal Canal Carcinoma With Recurrence.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2018 PURPOSE: Imaging parameters from 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) before and after chemoradiation therapy (CRT) for anal canal cancer correlate with clinical outcomes. This prospective, hypothesis-generating pilot study inv ... Full text Link to item Cite

The role of external beam radiotherapy in the treatment of hepatocellular cancer.

Journal Article Cancer · September 1, 2018 Hepatocellular carcinoma (HCC) is increasing in incidence and mortality. Although the prognosis remains poor, long-term survival has improved from 3% in 1970 to an 18% 5-year survival rate today. This is likely because of the introduction of well tolerated ... Full text Link to item Cite

Anal Carcinoma, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · July 2018 The NCCN Guidelines for Anal Carcinoma provide recommendations for the management of patients with squamous cell carcinoma of the anal canal or perianal region. Primary treatment of anal cancer usually includes chemoradiation, although certain lesions can ... Full text Link to item Cite

Rectal Cancer, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · July 2018 The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Rectal Cancer address diagnosis, staging, surgical management, perioperative treatment, management of recurrent and metastatic disease, disease surveillance, and survivorship in patien ... Full text Link to item Cite

Management of Locoregional Rectal Cancer.

Journal Article J Natl Compr Canc Netw · May 2018 The NCCN Guidelines for Rectal Cancer are now more closely aligned with those for colon cancer. A new MRI-based definition of the rectum has been included and the use of MRI in staging has been elevated in importance. There is a new emphasis on neoadjuvant ... Full text Link to item Cite

The Selective Use of Radiation Therapy in Rectal Cancer Patients.

Journal Article Curr Oncol Rep · April 11, 2018 PURPOSE OF REVIEW: Colorectal cancer has a high global incidence, and standard treatment employs a multimodality approach. In addition to cure, minimizing treatment-related toxicity and improving the therapeutic ratio is a common goal. The following articl ... Full text Link to item Cite

Role of radiotherapy in locally advanced pancreatic cancer

Chapter · April 11, 2018 Pancreatic cancer carries a poor prognosis regardless of stage, and incidence and death rates are increasing. Pancreatic cancer is divided into four general categories, resectable, borderline resectable, locally advanced/unresectable, and metastatic. Only ... Full text Cite

NCCN Guidelines Insights: Colon Cancer, Version 2.2018.

Journal Article J Natl Compr Canc Netw · April 2018 The NCCN Guidelines for Colon Cancer provide recommendations regarding diagnosis, pathologic staging, surgical management, perioperative treatment, surveillance, management of recurrent and metastatic disease, and survivorship. These NCCN Guidelines Insigh ... Full text Link to item Cite

Adjuvant Chemoradiotherapy With Epirubicin, Cisplatin, and Fluorouracil Compared With Adjuvant Chemoradiotherapy With Fluorouracil and Leucovorin After Curative Resection of Gastric Cancer: Results From CALGB 80101 (Alliance).

Journal Article J Clin Oncol · November 10, 2017 Purpose After curative resection of gastric or gastroesophageal junction adenocarcinoma, Intergroup Trial 0116 (Phase III trial of postoperative adjuvant radiochemotherapy for high risk gastric and gastroesophageal junction adenocarcinoma: Demonstrated sup ... Full text Link to item Cite

Targeting CXCR4-dependent immunosuppressive Ly6Clow monocytes improves antiangiogenic therapy in colorectal cancer.

Journal Article Proc Natl Acad Sci U S A · September 26, 2017 Antiangiogenic therapy with antibodies against VEGF (bevacizumab) or VEGFR2 (ramucirumab) has been proven efficacious in colorectal cancer (CRC) patients. However, the improvement in overall survival is modest and only in combination with chemotherapy. Thu ... Full text Link to item Cite

Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy.

Journal Article J Clin Invest · August 1, 2017 Current anti-VEGF therapies for colorectal cancer (CRC) provide limited survival benefit, as tumors rapidly develop resistance to these agents. Here, we have uncovered an immunosuppressive role for nonclassical Ly6Clo monocytes that mediates resistance to ... Full text Link to item Cite

Anal cancer

Chapter · May 10, 2017 Cite

Pancreatic cancer

Chapter · May 10, 2017 Cite

Total neoadjuvant therapy for rectal cancer: An emerging option.

Journal Article Cancer · May 1, 2017 The treatment of locally advanced rectal cancer (LARC) has benefited from improved surgical techniques and from the implementation of neoadjuvant chemoradiotherapy (CRT), which have markedly decreased the rates of local recurrence. However, distant metasta ... Full text Link to item Cite

Neoadjuvant long-course chemoradiation remains strongly favored over short-course radiotherapy by radiation oncologists in the United States.

Journal Article Cancer · April 15, 2017 BACKGROUND: Short-course radiotherapy (SC-RT) and long-course chemoradiotherapy (LC-CRT) are accepted neoadjuvant treatments of rectal cancer. In the current study, the authors surveyed US radiation oncologists to assess practice patterns and attitudes reg ... Full text Link to item Cite

Colon Cancer, Version 1.2017, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · March 2017 This portion of the NCCN Guidelines for Colon Cancer focuses on the use of systemic therapy in metastatic disease. Considerations for treatment selection among 32 different monotherapies and combination regimens in up to 7 lines of therapy have included tr ... Full text Link to item Cite

Final Results of NRG Oncology RTOG 0246: An Organ-Preserving Selective Resection Strategy in Esophageal Cancer Patients Treated with Definitive Chemoradiation.

Journal Article J Thorac Oncol · February 2017 INTRODUCTION: The impact of selective surgical resection for patients with esophageal cancer treated with definitive chemoradiation has not been clearly evaluated long-term. METHODS: NRG (National Surgical Adjuvant Breast and Bowel Project, Radiation Thera ... Full text Link to item Cite

The Use of Re-irradiation in Locally Recurrent, Non-metastatic Rectal Cancer.

Journal Article Ann Surg Oncol · October 2016 BACKGROUND: The optimal approach to patients with locally recurrent, non-metastatic rectal cancer is unclear. This study evaluates the outcomes and toxicity associated with pelvic re-irradiation. METHODS: Patients undergoing re-irradiation for locally recu ... Full text Link to item Cite

Gastric Cancer, Version 3.2016, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · October 2016 Gastric cancer is the fifth most frequently diagnosed cancer and the third leading cause of death from cancer in the world. Several advances have been made in the staging procedures, imaging techniques, and treatment approaches. The NCCN Clinical Practice ... Full text Link to item Cite

Role of Adjuvant Radiotherapy in Locally Advanced Colonic Carcinoma in the Modern Chemotherapy Era.

Journal Article Ann Surg Oncol · March 2016 BACKGROUND: The role of adjuvant radiation therapy (RT) in the treatment of resected, locally advanced colon cancer is unclear. One randomized controlled trial (Intergroup-0130) addressed this question but failed to meet its accrual goals. Since this trial ... Full text Link to item Cite

Nonoperative management of rectal cancer.

Journal Article Cancer · January 1, 2016 Surgery has long been the primary curative modality for localized rectal cancer. Neoadjuvant chemoradiation has significantly improved local control rates and, in a significant minority, eradicated all disease. Patients who achieve a pathologic complete re ... Full text Link to item Cite

A current perspective on stereotactic body radiation therapy for pancreatic cancer.

Journal Article Onco Targets Ther · 2016 Pancreatic cancer is a formidable malignancy with poor outcomes. The majority of patients are unable to undergo resection, which remains the only potentially curative treatment option. The management of locally advanced (unresectable) pancreatic cancer is ... Full text Open Access Link to item Cite

Reflections from a chair: Leadership of a clinical department at an academic medical center.

Journal Article Cancer · November 1, 2015 The leadership position of an academic departmental chair can be a positive and rewarding opportunity. These rewards principally stem from the success of the faculty, residents, other trainees, nurses, and everyone supporting the department. With health ca ... Full text Link to item Cite

Investigation of the Lack of Angiogenesis in the Formation of Lymph Node Metastases.

Journal Article J Natl Cancer Inst · September 2015 BACKGROUND: To date, antiangiogenic therapy has failed to improve overall survival in cancer patients when used in the adjuvant setting (local-regional disease with no detectable systemic metastasis). The presence of lymph node metastases worsens prognosis ... Full text Link to item Cite

Adjuvant radiation therapy for pancreatic cancer: a review of the old and the new.

Journal Article J Gastrointest Oncol · August 2015 Surgery represents the only potential curative treatment option for patients diagnosed with pancreatic adenocarcinoma. Despite aggressive surgical management for patients deemed to be resectable, rates of local recurrence and/or distant metastases remain h ... Full text Link to item Cite

Human papillomavirus tumor infection in esophageal squamous cell carcinoma.

Journal Article J Gastrointest Oncol · June 2015 The association between human papillomavirus (HPV) and esophageal squamous cell carcinoma (ESCC) has been recognized for over three decades. Recently, multiple meta-analyses have drawn upon existing literature to assess the strength of the HPV-ESCC linkage ... Full text Link to item Cite

Rectal Cancer, Version 2.2015.

Journal Article J Natl Compr Canc Netw · June 2015 The NCCN Guidelines for Rectal Cancer begin with the clinical presentation of the patient to the primary care physician or gastroenterologist and address diagnosis, pathologic staging, surgical management, perioperative treatment, posttreatment surveillanc ... Full text Link to item Cite

Esophageal and esophagogastric junction cancers, version 1.2015.

Journal Article J Natl Compr Canc Netw · February 2015 Esophageal cancer is the sixth most common cause of cancer deaths worldwide. Adenocarcinoma is more common in North America and Western European countries, originating mostly in the lower third of the esophagus, which often involves the esophagogastric jun ... Full text Link to item Cite

Cancer of the colon

Chapter · January 7, 2015 Cite

Cancer of the rectum

Chapter · January 7, 2015 Cite

Cancer of the stomach

Chapter · January 7, 2015 Cite

Efficacy endpoints of radiation therapy group protocol 0247: a randomized, phase 2 study of neoadjuvant radiation therapy plus concurrent capecitabine and irinotecan or capecitabine and oxaliplatin for patients with locally advanced rectal cancer.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2015 PURPOSE: To report secondary efficacy endpoints of Radiation Therapy Oncology Group protocol 0247, primary endpoint analysis of which demonstrated that preoperative radiation therapy (RT) with capecitabine plus oxaliplatin achieved a pathologic complete re ... Full text Link to item Cite

Anal canal cancer

Chapter · January 1, 2015 Radiation therapy with concurrent chemotherapy is the standard treatment for patients with nonmetastatic squamous cell carcinoma of the anal canal. In the studies that established this approach, high rates of locoregional control have been reported, but th ... Full text Cite

Colon Cancer

Chapter · January 1, 2015 Full text Cite

Intraoperative Irradiation

Chapter · January 1, 2015 Full text Cite

Incidence and prognostic impact of high-risk HPV tumor infection in cervical esophageal carcinoma.

Journal Article J Gastrointest Oncol · December 2014 BACKGROUND: Cervical esophageal carcinoma (CEC) is an uncommon malignancy. Limited data supports the use of definitive chemoradiotherapy (CRT) as primary treatment. Furthermore, the role of human papillomavirus (HPV) tumor infection in CEC remains unknown. ... Full text Link to item Cite

Patterns of failure for stage I ampulla of Vater adenocarcinoma: a single institutional experience.

Journal Article J Gastrointest Oncol · December 2014 BACKGROUND: Ampullary adenocarcinoma is a rare malignancy associated with a relatively favorable prognosis. Given high survival rates in stage I patients reported in small series with surgery alone, adjuvant chemoradiotherapy (CRT) has traditionally been r ... Full text Link to item Cite

Intraoperative radiotherapy in the treatment of gastrointestinal malignancies

Journal Article Translational Cancer Research · December 1, 2014 Intraoperative radiotherapy (IORT) is a technique that allows delivery of a single high dose of radiation to a target volume during surgery. Where conventional external beam radiation therapy (EBRT) is limited by the normal tissue tolerance of abdominal an ... Full text Cite

Short-course versus long-course chemoradiation in rectal cancer--time to change strategies?

Journal Article Curr Treat Options Oncol · September 2014 There is significant debate regarding the optimal neoadjuvant regimen for resectable rectal cancer patients. Short-course radiotherapy, a standard approach throughout most of northern Europe, is generally defined as 25 Gy in 5 fractions over the course of ... Full text Link to item Cite

Patterns of recurrence after trimodality therapy for esophageal cancer.

Journal Article Cancer · July 15, 2014 BACKGROUND: Patterns of failure after neoadjuvant chemoradiotherapy and surgery for esophageal cancer are poorly defined. METHODS: All patients in the current study were treated with trimodality therapy for nonmetastatic esophageal cancer from 1995 to 2009 ... Full text Link to item Cite

Colon cancer, version 3.2014.

Journal Article J Natl Compr Canc Netw · July 2014 The NCCN Guidelines for Colon Cancer address diagnosis, pathologic staging, surgical management, perioperative treatment, posttreatment surveillance, management of recurrent and metastatic disease,and survivorship. This portion of the guidelines focuses on ... Full text Link to item Cite

Radiotherapy for Gastrointestinal Malignancies

Chapter · June 20, 2014 This chapter talks about four case studies of radiotherapy for gastrointestinal malignancies. One of the case study, a 65-year-old female presents with painless jaundice and diarrhea for 1 month. Labs show an elevation in liver function tests and total bil ... Full text Cite

The role of intraoperative radiation therapy in patients with pancreatic cancer.

Journal Article Semin Radiat Oncol · April 2014 Intraoperative radiation therapy (IORT) techniques allow for the delivery of high doses of radiation therapy while excluding part or all of the nearby dose-limiting sensitive structures. Therefore, the effective radiation dose is increased and local tumor ... Full text Link to item Cite

A prospective feasibility study of respiratory-gated proton beam therapy for liver tumors.

Journal Article Pract Radiat Oncol · 2014 PURPOSE: To evaluate the feasibility of a respiratory-gated proton beam therapy for liver tumors. METHODS AND MATERIALS: Fifteen patients were enrolled in a prospective institutional review board-approved protocol. Eligibility criteria included Childs-Pugh ... Full text Link to item Cite

A paucity of practicality puts photons ahead of protons

Journal Article Clinical Advances in Hematology and Oncology · January 1, 2014 Cite

Incidence and prognostic impact of high-risk HPV tumor infection in cervical esophageal carcinoma

Journal Article Journal of Gastrointestinal Oncology · January 1, 2014 Background: Cervical esophageal carcinoma (CEC) is an uncommon malignancy. Limited data supports the use of definitive chemoradiotherapy (CRT) as primary treatment. Furthermore, the role of human papillomavirus (HPV) tumor infection in CEC remains unknown. ... Full text Cite

Updated long-term outcomes and prognostic factors for patients with unresectable locally advanced pancreatic cancer treated with intraoperative radiotherapy at the Massachusetts General Hospital, 1978 to 2010.

Journal Article Cancer · December 1, 2013 BACKGROUND: In the current study, the authors evaluated long-term outcomes, intraoperative radiotherapy (IORT)-related toxicity, and prognostic factors for overall survival (OS) among patients with unresectable locally advanced pancreatic cancer (LAPC) who ... Full text Link to item Cite

Anal carcinoma: impact of TN category of disease on survival, disease relapse, and colostomy failure in US Gastrointestinal Intergroup RTOG 98-11 phase 3 trial.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2013 PURPOSE: The long-term update of US GI Intergroup RTOG 98-11 anal cancer trial found that concurrent chemoradiation (CCRT) with fluorouracil (5-FU) plus mitomycin had a significant impact on disease-free survival (DFS) and overall survival (OS) compared wi ... Full text Link to item Cite

Neoadjuvant chemoradiation for distal rectal cancer: 5-year updated results of a randomized phase 2 study of neoadjuvant combined modality chemoradiation for distal rectal cancer.

Journal Article Int J Radiat Oncol Biol Phys · July 1, 2013 PURPOSE: To assess the efficacy of 2 different approaches to neoadjuvant chemoradiation for distal rectal cancers. METHODS AND MATERIALS: One hundred six patients with T3/T4 distal rectal cancers were randomized in a phase 2 study. Patients received either ... Full text Link to item Cite

Practical radiation oncology for surgeons.

Journal Article Surg Oncol Clin N Am · July 2013 Full text Link to item Cite

RTOG 0529: a phase 2 evaluation of dose-painted intensity modulated radiation therapy in combination with 5-fluorouracil and mitomycin-C for the reduction of acute morbidity in carcinoma of the anal canal.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2013 PURPOSE: A multi-institutional phase 2 trial assessed the utility of dose-painted intensity modulated radiation therapy (DP-IMRT) in reducing grade 2+ combined acute gastrointestinal and genitourinary adverse events (AEs) of 5-fluorouracil (5FU) and mitomy ... Full text Link to item Cite

Gastric cancer, version 2.2013: featured updates to the NCCN Guidelines.

Journal Article J Natl Compr Canc Netw · May 1, 2013 The NCCN Clinical Practice Guidelines in Oncology for Gastric Cancer provide evidence- and consensus-based recommendations for a multidisciplinary approach for the management of patients with gastric cancer. For patients with resectable locoregional cancer ... Full text Link to item Cite

Multidisciplinary management of locally advanced rectal cancer: neoadjuvant approaches.

Journal Article J Natl Compr Canc Netw · May 1, 2013 Although tumor biology and genomics of colon and rectal cancer are no different, patients with locally advanced rectal cancer (LARC) require neoadjuvant fluoropyrimidine-based chemoradiation and total mesorectal excision. In addition to known clinical risk ... Full text Link to item Cite

Localized colon cancer, version 3.2013: featured updates to the NCCN Guidelines.

Journal Article J Natl Compr Canc Netw · May 1, 2013 The NCCN Clinical Practice Guidelines in Oncology for Colon Cancer begin with the clinical presentation of the patient to the primary care physician or gastroenterologist and address diagnosis, pathologic staging, surgical management, perioperative treatme ... Full text Link to item Cite

The role of local excision in invasive adenocarcinoma of the ampulla of Vater.

Journal Article J Gastrointest Oncol · March 2013 BACKGROUND: Ampulla of Vater carcinomas are rare malignancies that have been traditionally treated with radical surgical resection. Given the mortality associated with pancreaticoduodenectomy, some patients may benefit from local resection. A single-instit ... Full text Link to item Cite

Metastatic colon cancer, version 3.2013: featured updates to the NCCN Guidelines.

Journal Article J Natl Compr Canc Netw · February 1, 2013 The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Colon Cancer begin with the clinical presentation of the patient to the primary care physician or gastroenterologist and address diagnosis, pathologic staging, surgical management, per ... Full text Link to item Cite

Preoperative chemoradiotherapy for locally advanced gastric cancer.

Journal Article Radiat Oncol · January 4, 2013 BACKGROUND: To examine toxicity and outcomes for patients treated with preoperative chemoradiotherapy (CRT) for gastric cancer. METHODS: Patients with gastroesophageal (GE) junction (Siewert type II and III) or gastric adenocarcinoma who underwent neoadjuv ... Full text Link to item Cite

Principles of radiotherapy

Chapter · January 1, 2013 Full text Cite

Technical considerations in radiation therapy for gastroesophageal junction cancer.

Journal Article Semin Radiat Oncol · January 2013 Contemporary randomized trials have demonstrated that radiation therapy combined with chemotherapy and surgery improves survival in both the neoadjuvant and adjuvant treatment of gastroesophageal cancers. Consequently, radiation treatment planning and admi ... Full text Link to item Cite

Implementing and integrating a clinically driven electronic medical record for radiation oncology in a large medical enterprise.

Journal Article Front Oncol · 2013 PURPOSE/OBJECTIVE: While our department is heavily invested in computer-based treatment planning, we historically relied on paper-based charts for management of Radiation Oncology patients. In early 2009, we initiated the process of conversion to an electr ... Full text Link to item Cite

Long-term update of US GI intergroup RTOG 98-11 phase III trial for anal carcinoma: survival, relapse, and colostomy failure with concurrent chemoradiation involving fluorouracil/mitomycin versus fluorouracil/cisplatin.

Journal Article J Clin Oncol · December 10, 2012 PURPOSE: On initial publication of GI Intergroup Radiation Therapy Oncology Group (RTOG) 98-11 [A Phase III Randomized Study of 5-Fluorouracil (5-FU), Mitomycin, and Radiotherapy Versus 5-Fluorouracil, Cisplatin and Radiotherapy in Carcinoma of the Anal Ca ... Full text Link to item Cite

Rectal cancer.

Journal Article J Natl Compr Canc Netw · December 1, 2012 These NCCN Clinical Practice Guidelines in Oncology provide recommendations for the management of rectal cancer, beginning with the clinical presentation of the patient to the primary care physician or gastroenterologist through diagnosis, pathologic stagi ... Full text Link to item Cite

Weekly paclitaxel, gemcitabine, and external irradiation followed by randomized farnesyl transferase inhibitor R115777 for locally advanced pancreatic cancer

Journal Article OncoTargets and Therapy · December 1, 2012 Purpose: The Radiation Therapy Oncology Group (RTOG) multi-institutional Phase II study 98-12, evaluating paclitaxel and concurrent radiation (RT) for locally advanced pancreatic cancer, demonstrated a median survival of 11.3 months and a 1-year survival o ... Full text Cite

Anal Cancer

Journal Article · November 15, 2012 This chapter provides an overview of the epidemiology, diagnosis, and treatment of the various tumors that arise in the anal canal and surrounding perianal skin. In particular, we focus on the evolution of treatment for squamous cell anal canal cancers, an ... Full text Cite

Five year results of US intergroup/RTOG 9704 with postoperative CA 19-9 ≤90 U/mL and comparison to the CONKO-001 trial.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2012 PURPOSE: Radiation Therapy Oncology Group (RTOG) trial 9704 was the largest randomized trial to use adjuvant chemoradiation therapy for patients with pancreatic cancer. This report analyzes 5-year survival by serum level of tumor marker CA 19-9 of ≤90 vs > ... Full text Link to item Cite

Compliance with therapeutic guidelines in Radiation Therapy Oncology Group prospective gastrointestinal clinical trials.

Journal Article Radiother Oncol · October 2012 BACKGROUND: This report analyzes the adherence to radiation therapy protocol guidelines in contemporary Radiation Therapy Oncology Group (RTOG) gastrointestinal trials. We aim to provide insight into current standards and compliance of radiation therapy fi ... Full text Link to item Cite

Resected pancreatic neuroendocrine tumors: patterns of failure and disease-related outcomes with or without radiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2012 PURPOSE: Pancreatic neuroendocrine tumors (NET) are rare and have better disease-related outcomes compared with pancreatic adenocarcinoma. Surgical resection remains the standard of care, although many patients present with locally advanced or metastatic d ... Full text Link to item Cite

Does preoperative therapy optimize outcomes in patients with resectable pancreatic cancer?

Journal Article J Surg Oncol · July 1, 2012 The objective of this study was to compare survival between all patients with radiographically resectable adenocarcinoma of the proximal pancreas who underwent preoperative chemoradiation therapy (PRE-OP CRT) or surgical exploration first (SURGERY) with "i ... Full text Link to item Cite

Pelvic normal tissue contouring guidelines for radiation therapy: a Radiation Therapy Oncology Group consensus panel atlas.

Journal Article Int J Radiat Oncol Biol Phys · July 1, 2012 PURPOSE: To define a male and female pelvic normal tissue contouring atlas for Radiation Therapy Oncology Group (RTOG) trials. METHODS AND MATERIALS: One male pelvis computed tomography (CT) data set and one female pelvis CT data set were shared via the Im ... Full text Link to item Cite

Pancreatic neuroendocrine tumors with involved surgical margins: prognostic factors and the role of adjuvant radiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · July 1, 2012 PURPOSE: Pancreatic neuroendocrine tumors (pNET) are rare neoplasms associated with poor outcomes without resection, and involved surgical margins are associated with a worse prognosis. The role of adjuvant radiotherapy (RT) in these patients has not been ... Full text Link to item Cite

Accomplishments in 2011 in Gastrointestinal Oncology

Journal Article Gastrointestinal Cancer Research · July 1, 2012 Cite

Potential novel drugs to combine with radiation in rectal cancer

Journal Article Current Colorectal Cancer Reports · June 1, 2012 The management of rectal cancer has seen significant advances in surgery, radiation therapy, and chemotherapy in recent years. These advances have translated into improved rates of local and distant disease control, survival, and quality of life for these ... Full text Cite

Carcinoma of the ampulla of Vater: patterns of failure following resection and benefit of chemoradiotherapy.

Journal Article Ann Surg Oncol · May 2012 BACKGROUND: Ampullary carcinoma is a rare malignancy. Despite radical resection, survival rates remain low with high rates of local failure. We performed a single-institution outcomes analysis to define the role of concurrent chemoradiotherapy (CRT) in add ... Full text Link to item Cite

The Ninth Annual ISGIO Meeting.

Journal Article Gastrointest Cancer Res · May 2012 Link to item Cite

Safety and efficacy of stereotactic radiosurgery and adjuvant bevacizumab in patients with recurrent malignant gliomas.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2012 PURPOSE: Patients with recurrent malignant gliomas treated with stereotactic radiosurgery (SRS) and multiagent systemic therapies were reviewed to determine the effects of patient- and treatment-related factors on survival and toxicity. METHODS AND MATERIA ... Full text Link to item Cite

Anal Carcinoma, Version 2.2012: featured updates to the NCCN guidelines.

Journal Article J Natl Compr Canc Netw · April 2012 The workup and management of squamous cell anal carcinoma, which represents the most common histologic form of the disease, are addressed in the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Anal Carcinoma. These NCCN Guidelines Insig ... Full text Link to item Cite

A Phase II study of a paclitaxel-based chemoradiation regimen with selective surgical salvage for resectable locoregionally advanced esophageal cancer: initial reporting of RTOG 0246.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2012 PURPOSE: The strategy of definitive chemoradiation with selective surgical salvage in locoregionally advanced esophageal cancer was evaluated in a Phase II trial in Radiation Therapy Oncology Group (RTOG)-affiliated sites. METHODS AND MATERIALS: The study ... Full text Link to item Cite

Pancreas

Chapter · March 28, 2012 Cite

Stomach

Chapter · March 28, 2012 Cite

Radiation Therapy Oncology Group 0247: a randomized Phase II study of neoadjuvant capecitabine and irinotecan or capecitabine and oxaliplatin with concurrent radiotherapy for patients with locally advanced rectal cancer.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2012 PURPOSE: To evaluate the rate of pathologic complete response (pCR) and the toxicity of two neoadjuvant chemoradiotherapy (chemoRT) regimens for Stage T3-T4 rectal cancer in a randomized Phase II study. METHODS AND MATERIALS: Patients with Stage T3 or T4 r ... Full text Link to item Cite

Failure to adhere to protocol specified radiation therapy guidelines was associated with decreased survival in RTOG 9704--a phase III trial of adjuvant chemotherapy and chemoradiotherapy for patients with resected adenocarcinoma of the pancreas.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2012 PURPOSE: In Radiation Therapy Oncology Group 9704, as previously published, patients with resected pancreatic adenocarcinoma received continuous infusion 5-FU and concurrent radiotherapy (5FU-RT). 5FU-RT treatment was preceded and followed by randomly assi ... Full text Link to item Cite

Intraoperative Irradiation

Chapter · January 1, 2012 Full text Cite

IMRT treatment of anal cancer with a scrotal shield.

Journal Article Med Dosim · 2012 The risk of sterility in males undergoing radiotherapy in the pelvic region indicates the use of a shielding device, which offers protection to the testes for patients wishing to maintain fertility. The use of such devices in the realm of intensity-modulat ... Full text Link to item Cite

Development of a 4D dosimetry simulation system in radiotherapy

Journal Article International Journal of Biomedical Engineering and Technology · January 1, 2012 4D CT image sets are used to encode patient-organ motion and to calculate the dose delivered during each respiratory phase. The dose-per-phase is summarised to the total dose via deformable registration. The system incorporates the actual beam parameters a ... Full text Cite

Tolerability of combined modality therapy for rectal cancer in elderly patients aged 75 years and older.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2011 PURPOSE: To determine the rate of treatment deviations during combined modality therapy for rectal cancer in elderly patients aged 75 years and older. METHODS AND MATERIALS: We reviewed the records of consecutively treated patients with rectal cancer aged ... Full text Link to item Cite

The influence of total nodes examined, number of positive nodes, and lymph node ratio on survival after surgical resection and adjuvant chemoradiation for pancreatic cancer: a secondary analysis of RTOG 9704.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2011 PURPOSE: Lymph node status is an important predictor of survival in pancreatic cancer. We performed a secondary analysis of Radiation Therapy Oncology Group (RTOG) 9704, an adjuvant chemotherapy and chemoradiation trial, to determine the influence of lymph ... Full text Link to item Cite

Radiotherapy in the treatment of patients with unresectable extrahepatic cholangiocarcinoma.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2011 PURPOSE: Extrahepatic cholangiocarcinoma is an uncommon but lethal malignancy. We analyzed the role of definitive chemoradiotherapy for patients with nonmetastatic, locally advanced extrahepatic cholangiocarcinoma treated at a single institution. METHODS A ... Full text Link to item Cite

Clinical practice guidelines in oncology

Journal Article JNCCN Journal of the National Comprehensive Cancer Network · November 1, 2011 The panel believes that a multidisciplinary approach is necessary for managing colorectal cancer. The panel endorses the concept that treating patients in a clinical trial has priority over standard or accepted therapy. The recommended surgical procedure f ... Cite

Colon cancer.

Journal Article J Natl Compr Canc Netw · November 2011 Full text Link to item Cite

Role of radiation therapy in patients with resectable pancreatic cancer

Journal Article Oncology · August 12, 2011 The 5-year overall survival of patients with pancreatic cancer is approximately 5%, with potentially resectable disease representing the curable minority. Although surgical resection remains the cornerstone of treatment, local and distant failure rates are ... Cite

Esophageal and esophagogastric junction cancers.

Journal Article J Natl Compr Canc Netw · August 1, 2011 Full text Link to item Cite

Beyond 5-fluorouracil: the emerging role of newer chemotherapeutics and targeted agents with radiation therapy.

Journal Article Semin Radiat Oncol · July 2011 The management of rectal cancer has undergone significant evolution with advances in surgery, radiation therapy, and chemotherapy. These advances have translated into improved rates of local control, survival, and quality of life. More recently, the integr ... Full text Link to item Cite

Role of radiation therapy in patients with resectable pancreatic cancer.

Journal Article Oncology (Williston Park) · July 2011 The 5-year overall survival of patients with pancreatic cancer is approximately 5%, with potentially resectable disease representing the curable minority. Although surgical resection remains the cornerstone of treatment, local and distant failure rates are ... Link to item Cite

Intraductal papillary mucinous adenocarcinoma of the pancreas: Clinical outcomes, prognostic factors, and the role of adjuvant therapy

Journal Article Gastrointestinal Cancer Research · July 1, 2011 Background: Pancreatic ductal adenocarcinoma (PDAC) arising in intraductal papillary mucinous neoplasms (IPMN) may represent a different biologic entity than classic PDAC, and there is little evidence to inform adjuvant treatment decisions. The purpose of ... Cite

Update on treatment advances in combined-modality therapy for anal and rectal carcinomas.

Journal Article Curr Oncol Rep · June 2011 Concurrent radiation therapy and chemotherapy is the primary treatment for patients with squamous cell tumors of the anal canal, and is also employed in the neoadjuvant setting for patients with stage II and III adenocarcinoma of the rectum. There is const ... Full text Link to item Cite

Fluorouracil-based chemoradiation with either gemcitabine or fluorouracil chemotherapy after resection of pancreatic adenocarcinoma: 5-year analysis of the U.S. Intergroup/RTOG 9704 phase III trial.

Journal Article Ann Surg Oncol · May 2011 BACKGROUND: The impact of the addition of gemcitabine to 5-fluorouracil (5-FU) chemoradiation (CRT) on 5-year overall survival (OS) in resected pancreatic adenocarcinoma are presented with updated results of a phase III trial. METHODS: After resection of p ... Full text Link to item Cite

Longitudinal quality-of-life analysis of RTOG 94-05 (Int 0123): A phase III trial of definitive chemoradiotherapy for esophageal cancer

Journal Article Gastrointestinal Cancer Research · March 1, 2011 Background: Longitudinal quality of life (QoL) was compared for patients with esophageal cancer receiving definitive chemoradiotherapy (CRT) with conventional-dose (CD) vs. high-dose (HD) radiotherapy as used in the RTOG phase III 94-05 trial (Intergroup 0 ... Cite

Colon Cancer

Chapter · January 1, 2011 Full text Cite

SU‐E‐T‐419: Clinical Protocol for the Use of Scrotal Shields in IMRT Treatment of Anal Cancer

Conference Medical Physics · January 1, 2011 Purpose: To implement a clinical protocol for the use of scrotal shields for anal cancer IMRT treatment. Methods and Results: (1) Simulation The patient is immobilized in a full‐body alpha‐cradle mold in the frog‐leg position. Further, the mold is built up ... Full text Cite

Intraoperative Irradiation

Chapter · January 1, 2011 Full text Cite

Introduction

Journal Article Ressourcement Thomism: Sacred Doctrine, the Sacraments, and the Moral Life · January 1, 2011 Full text Cite

Intensity-modulated radiation therapy for anal malignancies: a preliminary toxicity and disease outcomes analysis.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2010 PURPOSE: Intensity-modulated radiation therapy (IMRT) has the potential to reduce toxicities associated with chemoradiotherapy in the treatment of anal cancer. This study reports the results of using IMRT in the treatment of anal cancer. METHODS AND MATERI ... Full text Link to item Cite

Impact of overall treatment time on survival and local control in patients with anal cancer: a pooled data analysis of Radiation Therapy Oncology Group trials 87-04 and 98-11.

Journal Article J Clin Oncol · December 1, 2010 PURPOSE: To determine whether increased duration of radiation therapy (RT) and overall treatment (RX) time has a detrimental effect in anal cancer. PATIENTS AND METHODS: Data from Radiation Therapy Oncology Group (RTOG) 87-04 and RTOG 98-11 trials were com ... Full text Link to item Cite

Prognostic factors derived from a prospective database dictate clinical biology of anal cancer: the intergroup trial (RTOG 98-11).

Journal Article Cancer · September 1, 2010 BACKGROUND: Only 4 prospective randomized phase 3 trials have been reported for anal cancer. A prognostic factor analysis for anal cancer from a prospective database has been published from only 1 study (N = 110). To confirm and uncover new prognostic fact ... Full text Link to item Cite

Pancreatic adenocarcinoma.

Journal Article J Natl Compr Canc Netw · September 2010 Full text Link to item Cite

Intensity-modulated radiation therapy for anal cancer: toxicity versus outcomes.

Journal Article Oncology (Williston Park) · August 2010 The treatment of cancer of the anal canal has changed significantly over the past several decades. Although the abdominoperineal resection (APR) was the historical standard of care, a therapeutic paradigm shift occurred with the seminal work of Nigro, who ... Link to item Cite

Intensity-modulated radiation therapy for anal cancer: toxicity versus outcomes.

Journal Article Oncology (Williston Park, N.Y.) · August 1, 2010 The treatment of cancer of the anal canal has changed significantly over the past several decades. Although the abdominoperineal resection (APR) was the historical standard of care, a therapeutic paradigm shift occurred with the seminal work of Nigro, who ... Cite

Outcomes and tolerability of chemoradiation therapy for pancreatic cancer patients aged 75 years or older.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2010 PURPOSE: To review the outcomes and tolerability of full-dose chemoradiation in elderly patients aged 75 years or older with localized pancreatic cancer. METHODS AND MATERIALS: We retrospectively reviewed patients aged 75 years or older with nonmetastatic ... Full text Link to item Cite

Epigenetic markers in rectal cancer.

Journal Article Clin Cancer Res · May 15, 2010 DNA methylation changes in rectal cancer may serve as a new screening marker and a tool for monitoring recurrence. Importantly, these changes may also function as a predictive marker to allow appropriate exclusion of (neo)adjuvant therapies in patients at ... Full text Link to item Cite

Current and emerging treatment strategies for anal cancer.

Journal Article Curr Oncol Rep · May 2010 Concurrent radiotherapy and chemotherapy (5-fluorouracil and mitomycin-C) is established as a sphincter-preserving treatment for squamous cell carcinoma of the anal canal. However, there is room for improvement in rates of tumor control as well as a need t ... Full text Link to item Cite

Toxicity and outcomes after chemoradiation for esophageal cancer in patients age 75 or older.

Journal Article Dis Esophagus · May 2010 Randomized trials of chemoradiation for esophageal cancer have included very few patients age > or = 75. In this retrospective study, we describe the outcomes and toxicity of full-dose chemoradiation in elderly patients with esophageal cancer. Patients, ag ... Full text Link to item Cite

Gastric cancer.

Journal Article J Natl Compr Canc Netw · April 2010 Full text Link to item Cite

Nonoperative management of rectal cancer: current perspectives.

Journal Article Clin Colorectal Cancer · April 2010 While surgery plays a central role in the management of all stages of operable rectal cancer, nonoperative approaches for both early-stage and locally advanced disease are being explored. This comprehensive review summarizes the current literature regardin ... Full text Link to item Cite

Radiation Injury

Chapter · January 1, 2010 Full text Cite

Radiation therapy advances for treatment of anal cancer.

Journal Article J Natl Compr Canc Netw · January 2010 Radiation therapy (RT) is established as the primary treatment of squamous cell carcinoma of the anus. Multiple randomized trials have shown that combined modality therapy with RT, 5-fluorouracil, and mitomycin-C results in high rates of local control, dis ... Full text Link to item Cite

A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer.

Journal Article Oncologist · 2010 INTRODUCTION: Bevacizumab is increasingly being tested with neoadjuvant regimens in patients with localized cancer, but its effects on metastasis and survival remain unknown. This study examines the long-term outcome of clinical stage II/III rectal cancer ... Full text Link to item Cite

Plasma soluble VEGFR-1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer.

Journal Article Oncologist · 2010 We explored plasma and urinary concentrations of two members of the vascular endothelial growth factor (VEGF) family and their receptors as potential response and toxicity biomarkers of bevacizumab with neoadjuvant chemoradiation in patients with localized ... Full text Link to item Cite

NCCN clinical practice guidelines in oncology. Anal carcinoma.

Journal Article J Natl Compr Canc Netw · January 2010 Full text Link to item Cite

Consensus report of the national cancer institute clinical trials planning meeting on pancreas cancer treatment.

Journal Article J Clin Oncol · November 20, 2009 Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer mortality, despite significant improvements in diagnostic imaging and operative mortality rates. The 5-year survival rate remains less than 5% because of microscopic or gross met ... Full text Link to item Cite

Intensity-modulated radiation therapy for anal cancer.

Journal Article Oncology (Williston Park) · November 15, 2009 The contemporary treatment of anal cancer is combined-modality therapy with radiation therapy, fluorouracil, and mitomycin. This therapy results in long-term disease-free survival and sphincter preservation in the majority of patients. Tempering these posi ... Link to item Cite

Intensity-modulated radiation therapy for anal cancer

Journal Article ONCOLOGY · November 15, 2009 The contemporary treatment of anal cancer is combined-modality therapy with radiation therapy, fluorouracil, and mitomycin. This therapy results in long-term disease-free survival and sphincter preservation in the majority of patients. Tempering these posi ... Cite

Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer.

Journal Article Cancer Res · October 15, 2009 Clinical studies converge on the observation that circulating cytokines are elevated in most cancer patients by anti-vascular endothelial growth factor (VEGF) therapy. However, the source of these molecules and their relevance in tumor escape remain unknow ... Full text Link to item Cite

Chemoradiotherapy in gastrointestinal malignancies.

Journal Article Clin Oncol (R Coll Radiol) · September 2009 Over the past 30 years, significant advances have been made in the integration of radiation therapy and chemotherapy in the treatment of patients with localised gastrointestinal malignancies. The therapeutic goal of chemoradiotherapy is to enhance local co ... Full text Link to item Cite

NCCN Clinical Practice Guidelines in Oncology: rectal cancer.

Journal Article J Natl Compr Canc Netw · September 2009 Full text Link to item Cite

NCCN Clinical Practice Guidelines in Oncology: colon cancer.

Journal Article J Natl Compr Canc Netw · September 2009 Full text Link to item Cite

Phase II study of bevacizumab with concurrent capecitabine and radiation followed by maintenance gemcitabine and bevacizumab for locally advanced pancreatic cancer: Radiation Therapy Oncology Group RTOG 0411.

Journal Article J Clin Oncol · September 1, 2009 PURPOSE: The primary objective of this study was to assess the 1-year survival of patients with locally advanced, unresectable pancreatic cancer treated with the combination of bevacizumab, capecitabine, and radiation. Secondary end points were toxicity, p ... Full text Link to item Cite

Elective clinical target volumes for conformal therapy in anorectal cancer: a radiation therapy oncology group consensus panel contouring atlas.

Journal Article Int J Radiat Oncol Biol Phys · July 1, 2009 PURPOSE: To develop a Radiation Therapy Oncology Group (RTOG) atlas of the elective clinical target volume (CTV) definitions to be used for planning pelvic intensity-modulated radiotherapy (IMRT) for anal and rectal cancers. METHODS AND MATERIALS: The Gast ... Full text Link to item Cite

Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study.

Journal Article J Clin Oncol · June 20, 2009 PURPOSE: To assess the safety and efficacy of neoadjuvant bevacizumab with standard chemoradiotherapy in locally advanced rectal cancer and explore biomarkers for response. PATIENTS AND METHODS: In a phase I/II study, 32 patients received four cycles of th ... Full text Link to item Cite

Biomarkers of response and resistance to antiangiogenic therapy.

Journal Article Nat Rev Clin Oncol · June 2009 No validated biological markers (or biomarkers) currently exist for appropriately selecting patients with cancer for antiangiogenic therapy. Nor are there biomarkers identifying escape pathways that should be targeted after tumors develop resistance to a g ... Full text Link to item Cite

Reply to C.D. Atkins

Journal Article Journal of Clinical Oncology · May 20, 2009 Full text Cite

Current management of anal canal cancer.

Journal Article Curr Oncol Rep · May 2009 Squamous cell carcinoma of the anal canal historically has been treated with abdominoperineal resection, resulting in high rates of morbidity and local recurrence. Pioneering work led to the finding that radiation therapy (RT) combined with 5-fluorouracil ... Full text Link to item Cite

Randomized phase II trial evaluating two paclitaxel and cisplatin-containing chemoradiation regimens as adjuvant therapy in resected gastric cancer (RTOG-0114).

Journal Article J Clin Oncol · April 20, 2009 PURPOSE: The investigational arm of INT0116, a fluorouracil (FU) and leucovorin-containing chemoradiotherapy regimen, is a standard treatment for patients with resected gastric cancer with a 2-year disease-free survival rate (DFS) of 52%. Toxicity is also ... Full text Link to item Cite

US intergroup anal carcinoma trial: tumor diameter predicts for colostomy.

Journal Article J Clin Oncol · March 1, 2009 PURPOSE: The US Gastrointestinal Intergroup Radiation Therapy Oncology Group 98-11 anal carcinoma trial showed that cisplatin-based concurrent chemoradiotherapy resulted in a significantly higher rate of colostomy compared with mitomycin-based therapy. Est ... Full text Link to item Cite

Metastatic Liver Cancer: Treatment: Radiation therapy

Journal Article · January 14, 2009 The liver is the most common site for blood-borne metastasis from colorectal cancers. Until the early 1980s, it was generally accepted that hepatic metastases from colorectal cancer represented just one site in a wide systemic dissemination of tumor, and h ... Full text Cite

SU‐FF‐T‐545: Feasibility Study for Treatment of Intracranial Multi‐Focal Stereotactic Radiosurgery with Multiple Intensity Modulated Arc Technique

Conference Medical Physics · January 1, 2009 Objectives: To investigate the feasibility of using an intensity modulated arc technique for multi‐focal intracranial stereotactic radiosurgery with a single isocenter setup to significantly decrease the treatment time. Methods: A Novalis Tx linear acceler ... Full text Cite

SU‐FF‐T‐548: Comparison of Cone‐Beam CT and Frame‐Based Localizations for Stereotactic Radiosurgery with Fixed Head Rings and Removable Frames

Conference Medical Physics · January 1, 2009 Objectives: To compare localization accuracy using both conventional frame‐based localizers and cone‐beam CT (CBCT) images for stereotactic radiosurgery (SRS). Methods: A SRS geometric phantom was used to verify the localization accuracy based on a SRS loc ... Full text Cite

Concurrent chemoradiotherapy in resected extrahepatic cholangiocarcinoma.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2009 PURPOSE: Extrahepatic cholangiocarcinoma is a rare malignancy. Despite radical resection, survival remains poor, with high rates of local and distant failure. To clarify the role of radiotherapy with chemotherapy, we performed a retrospective analysis of r ... Full text Link to item Cite

Postresection CA 19-9 predicts overall survival in patients with pancreatic cancer treated with adjuvant chemoradiation: a prospective validation by RTOG 9704.

Journal Article J Clin Oncol · December 20, 2008 PURPOSE: CA 19-9 is an important tumor marker in patients with pancreatic adenocarcinoma. A secondary end point of Radiation Therapy Oncology Group trial 9704 was prospective evaluation of the ability of postresectional CA 19-9 to predict survival. METHODS ... Full text Link to item Cite

Neoadjuvant Chemoradiation for Rectal Cancer

Journal Article Seminars in Colon and Rectal Surgery · December 1, 2008 Significant advances have been made in the treatment of rectal cancer patients. Phase III studies have demonstrated the efficacy of neoadjuvant and adjuvant radiation therapy and chemotherapy in improving the outcome of patients with locally advanced disea ... Full text Cite

Normalization of tumor vasculature and microenvironment

Journal Article · December 1, 2008 Solid tumors require blood vessels for growth, and many new cancer therapies are targeted against the tumor vasculature. The widely held view is that these antiangiogenic therapies destroy the tumor vasculature, thereby depriving the tumor of oxygen and nu ... Full text Cite

Thirty years of rectal cancer research: a brief history.

Journal Article Oncology (Williston Park) · November 15, 2008 Link to item Cite

Esophageal cancer.

Journal Article J Natl Compr Canc Netw · October 2008 Link to item Cite

Principles and techniques of radiation therapy for esophageal and gastroesophageal junction cancers.

Journal Article J Natl Compr Canc Netw · October 2008 Radiation therapy serves an integral role in the primary and adjuvant treatment of esophagus cancer. Radiation techniques continue to improve, providing more accurate localization of the tumor while limiting dose to normal structures. This article reviews ... Full text Link to item Cite

Phase II randomized trial of two nonoperative regimens of induction chemotherapy followed by chemoradiation in patients with localized carcinoma of the esophagus: RTOG 0113.

Journal Article J Clin Oncol · October 1, 2008 PURPOSE: Two nonoperative approaches (one without fluorouracil) using induction chemotherapy and then definitive chemoradiotherapy developed at two centers were compared in patients with localized esophageal cancer (LEC). The primary end point was to asses ... Full text Link to item Cite

Intersociety Radiation Oncology Summit-SCOPE II.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2008 Full text Link to item Cite

Evaluation of planned treatment breaks during radiation therapy for anal cancer: update of RTOG 92-08.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2008 PURPOSE: Radiation Therapy Oncology Group (RTOG) 92-08 began as a single arm, Phase II trial for patients with anal cancer consisting of radiation (RT) + 5-flourouracil + mitomycin-C with a mandatory 2-week break and was amended after completion to evaluat ... Full text Link to item Cite

An odd but synergistic couple: Immunotherapy combined with radiotherapy

Journal Article ONCOLOGY · August 1, 2008 In summary, there is considerable promise for combinations of immunotherapy with radiotherapy, but clinical experience is still limited. Preclinical models with greater relevance to human tumors should be used to continue identifying the best combinations ... Cite

Intensity-modulated radiation therapy for gastrointestinal tumors.

Journal Article Curr Oncol Rep · May 2008 Radiation plays an important role in the multimodal management of tumors of the gastrointestinal (GI) system. Intensity-modulated radiation therapy (IMRT) is a technological development that was introduced to limit the acute and late toxicities commonly as ... Full text Link to item Cite

Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial.

Journal Article JAMA · April 23, 2008 CONTEXT: Chemoradiation as definitive therapy is the preferred primary therapy for patients with anal canal carcinoma; however, the 5-year disease-free survival rate from concurrent fluorouracil/mitomycin and radiation is only approximately 65%. OBJECTIVE: ... Full text Link to item Cite

Emerging role of intensity-modulated radiation therapy in anorectal cancer.

Journal Article Expert Rev Anticancer Ther · April 2008 Although radiation therapy has an established role to play in the management of rectal and anal tumors, there are often treatment-related morbidities that negatively impact on patients. There is a long-standing interest in radiation oncology on maximizing ... Full text Link to item Cite

Is there a role for advanced radiation therapy technologies in the treatment of pancreatic adenocarcinoma?

Journal Article Future Oncol · April 2008 Pancreatic cancer remains a highly challenging problem in oncology. Oncologists continue to search for therapies that are more effective than those currently available to improve on the existing poor treatment results. Persistence of both systemic and loca ... Full text Link to item Cite

Integration of cone-beam CT in stereotactic body radiation therapy.

Journal Article Technol Cancer Res Treat · April 2008 This report describes the technique and initial experience using cone beam CT (CBCT) for localization of treatment targets in patients undergoing stereotactic body radiation therapy (SBRT). Patients selected for SBRT underwent 3-D or 4-D CT scans in a cust ... Full text Link to item Cite

A phase I study of UFT/leucovorin, carboplatin, and paclitaxel in combination with external beam radiation therapy for advanced esophageal carcinoma.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2008 PURPOSE: Concurrent chemotherapy and radiation therapy (RT) are used to treat patients with esophageal cancer. The optimal combination of chemotherapeutic agents with RT is not well established. We evaluated the safety and preliminary efficacy of a combina ... Full text Link to item Cite

Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: a randomized controlled trial.

Journal Article JAMA · March 5, 2008 CONTEXT: Among patients with locally advanced metastatic pancreatic adenocarcinoma, gemcitabine has been shown to improve outcomes compared with fluorouracil. OBJECTIVE: To determine if the addition of gemcitabine to adjuvant fluorouracil chemoradiation (c ... Full text Link to item Cite

Phase III trial of trimodality therapy with cisplatin, fluorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer: CALGB 9781.

Journal Article J Clin Oncol · March 1, 2008 PURPOSE: The primary treatment modality for patients with carcinoma of the esophagus or gastroesophageal junction has been surgery, although primary radiation therapy with concurrent chemotherapy produces similar results. As both have curative potential, t ... Full text Link to item Cite

Introduction

Chapter · January 1, 2008 The goal of this book is to provide practical guidance for anyone who is interested in initiating a teledermatology program or expanding their current system. This book was written for a wide audience to include anyone in a private practice, academic cente ... Full text Cite

Duodenal adenocarcinoma: patterns of failure after resection and the role of chemoradiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2007 PURPOSE: To report patterns of disease recurrence after resection of adenocarcinoma of the duodenum and compare outcomes between patients undergoing surgery only vs. surgery with concurrent chemotherapy and radiation therapy (CT-RT). METHODS AND MATERIALS: ... Full text Link to item Cite

The impact of advanced technologies on treatment deviations in radiation treatment delivery.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2007 PURPOSE: To assess the impact of new technologies on deviation rates in radiation therapy (RT). METHODS AND MATERIALS: Treatment delivery deviations in RT were prospectively monitored during a time of technology upgrade. In January 2003, our department had ... Full text Link to item Cite

Radiation therapy in stage II and III rectal cancer.

Journal Article Clin Cancer Res · November 15, 2007 Over the past 25 years, significant advances have been made in the management of patients with rectal cancer. Phase III studies have shown the efficacy of postoperative radiation therapy and chemotherapy in improving local control and survival of patients ... Full text Link to item Cite

Discussion: Surgical issues in colon and rectal cancers

Journal Article Clinical Cancer Research · November 15, 2007 Cite

Discussion: Issues in adjuvant therapy for early-stage disease

Journal Article Clinical Cancer Research · November 15, 2007 Cite

New approaches to assessing and treating early-stage colon and rectal cancer: summary statement from 2007 Santa Monica Conference.

Journal Article Clin Cancer Res · November 15, 2007 The 2007 Santa Monica Conference on Assessing and Treating Early-Stage Colon and Rectal Cancer, a multidisciplinary meeting of leaders in surgery, medical and radiation oncology, and pathology, was convened on January 12 to 13, 2007. The purpose of the mee ... Full text Link to item Cite

Paclitaxel-based chemoradiotherapy in the treatment of patients with operable esophageal cancer.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2007 PURPOSE: To compare a neoadjuvant regimen of cisplatin/5-fluorouracil (5-FU) and concurrent radiation therapy (RT) with paclitaxel-based regimens and RT in the management of operable esophageal (EC)/gastroesophageal junction (GEJ) cancer. METHODS AND MATER ... Full text Link to item Cite

Monitoring changes in the microenvironment during targeted therapies

Journal Article ONCOLOGY · October 1, 2007 Both antiangiogenic and vascular-targeted therapies hold great promise. The approval of some antiangiogenic agents in combination with other therapies bode well for the future clinical use of these agents. Similarly, the increased interest in vascular-targ ... Cite

Antiangiogenics: the potential role of integrating this novel treatment modality with chemoradiation for solid cancers.

Journal Article J Clin Oncol · September 10, 2007 Although still in very early stages of clinical development, the combination of antiangiogenics with contemporary chemoradiotherapy regimens has emerged as a feasible and promising approach to many cancers. We review the rationale and the current understan ... Full text Link to item Cite

Combined-modality therapy for rectal cancer: future prospects.

Journal Article Clin Colorectal Cancer · September 2007 The management of rectal cancer has undergone significant evolution with advances in surgery, radiation therapy, and chemotherapy. These advances have translated into improved rates of local control, survival, and quality of life. More recently, the integr ... Full text Link to item Cite

Long-term results of RTOG trial 8911 (USA Intergroup 113): a random assignment trial comparison of chemotherapy followed by surgery compared with surgery alone for esophageal cancer.

Journal Article J Clin Oncol · August 20, 2007 PURPOSE: We update Radiation Therapy Oncology Group trial 8911 (USA Intergroup 113), a comparison of chemotherapy plus surgery versus surgery alone for patients with localized esophageal cancer. The relationship between resection type and between tumor res ... Full text Link to item Cite

Targeted therapy in rectal cancer.

Journal Article Oncology (Williston Park) · August 2007 Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) are often overexpressed in colorectal cancer and are associated with inferior outcomes. Based on successful randomized phase III trials, anti-EGFR and anti-VEGF therapeut ... Link to item Cite

Is radiation therapy required for patients with intermediate-risk rectal cancer?

Journal Article Clin Adv Hematol Oncol · August 2007 Randomized trials have demonstrated that radiation therapy improves local control in patients with rectal cancer. Because pelvic irradiation may result in acute and/or late morbidity, identification of patients with the highest probability of benefiting fr ... Link to item Cite

Bevacizumab, oxaliplatin, and capecitabine with radiation therapy in rectal cancer: Phase I trial results.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2007 PURPOSE: The overexpression of vascular endothelial growth factor (VEGF) is associated with poor outcomes in colorectal cancer patients. Bevacizumab, a VEGF inhibitor, enhances the effects of chemotherapy and radiation therapy on tumor cytotoxicity in prec ... Full text Link to item Cite

VEGF-targeted cancer therapy strategies: current progress, hurdles and future prospects.

Journal Article Trends Mol Med · June 2007 Despite setbacks, the clinical development of antiangiogenic agents has accelerated remarkably over the past 3-4 years. Consequently, there are currently three direct inhibitors of the VEGF pathway approved for use in cancer therapy. Other agents that bloc ... Full text Link to item Cite

Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer.

Journal Article Nat Clin Pract Oncol · May 2007 BACKGROUND: Localized rectal cancer responds well to 5-fluorouracil and radiation-based regimens. A phase I-II trial is currently testing the efficacy of adding bevacizumab, a VEGF-specific antibody, to standard chemoradiotherapy. The case presented here i ... Full text Link to item Cite

Reduction of organ motion by combined cardiac gating and respiratory gating.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2007 PURPOSE: To investigate whether the effect of organ motion can be further reduced with the application of a cardiac gating technique, together with respiratory gating. METHODS AND MATERIALS: Axial and coronal images through the heart and liver were continu ... Full text Link to item Cite

Surrogate biomarkers for anti-angiogenic therapy for advanced colorectal cancer

Journal Article Current Colorectal Cancer Reports · May 1, 2007 Vascular endothelial growth factor (VEGF)-overexpressed in colorectal cancer-is associated with disease progression and inferior survival. Based on successful, randomized, phase III trials, anti-VEGF therapeutics have entered clinical practice. Bevacizumab ... Full text Cite

Evaluation of an artificial intelligence guided inverse planning system: clinical case study.

Journal Article Radiother Oncol · April 2007 PURPOSE: An artificial intelligence (AI) guided method for parameter adjustment of inverse planning was implemented on a commercial inverse treatment planning system. For evaluation purpose, four typical clinical cases were tested and the results from both ... Full text Link to item Cite

A Phase I study of capecitabine, carboplatin, and paclitaxel with external beam radiation therapy for esophageal carcinoma.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2007 PURPOSE: Concurrent chemotherapy and radiation therapy (RT) are used to treat patients with esophageal cancer. The optimal combination of chemotherapeutic agents with RT is undefined. We evaluated a combination of capecitabine, carboplatin, and paclitaxel ... Full text Link to item Cite

Intraoperative radiation therapy.

Journal Article J Clin Oncol · March 10, 2007 Intraoperative radiation therapy (IORT) is the delivery of irradiation at the time of an operation. This is performed by different techniques including intraoperative electron beam techniques and high-dose rate brachytherapy. IORT is usually given in combi ... Full text Link to item Cite

In reply [10]

Journal Article Journal of Clinical Oncology · February 10, 2007 Full text Cite

MO‐D‐M100F‐03: Latest Clinical Development for GI

Journal Article Medical Physics · January 1, 2007 There has been significant progress in the technical delivery of radiation therapy in GI cancer. These innovations have included the use of intensity modulated radiation therapy, image guidance radiation therapy, and stereotactic radiation therapy. One of ... Full text Cite

Antiangiogenic cancer therapy

Chapter · January 1, 2007 The targeting of tumor angiogenesis has evolved into one of the most widely pursued therapeutic strategies. However, as of yet, no antiangiogenic agent used as a monotherapy has demonstrated a survival benefit in a randomized Phase III trial. The combinati ... Full text Cite

Adjuvant therapy of pancreatic cancer.

Journal Article Cancer J · 2007 Of the 33,370 patients diagnosed with pancreatic carcinoma in the United States this year, approximately 20% will present with resectable disease. At present, surgery offers the only means of cure. Radiation therapy and chemotherapy approaches have been us ... Full text Link to item Cite

Advanced radiation therapy technologies in the treatment of rectal and anal cancer: intensity-modulated photon therapy and proton therapy.

Journal Article Clin Colorectal Cancer · January 2007 Intensity-modulated photon radiation therapy (RT; IMRT) and proton therapy are advanced radiation technologies that permit improved conformation of radiation dose to target structures while limiting irradiation of surrounding normal tissues. Application of ... Full text Link to item Cite

SU‐FF‐T‐252: Improvement of Localization Accuracy by Using 3D Cone Beam CT for Stereotactic Body Radiation Therapy of Liver, Lung and Spine Lesions

Conference Medical Physics · January 1, 2007 Purpose: To compare treatment isocenter placement based on OBI 2D kV imaging and OBI 3D‐CBCT imaging for patients undergoing SBRT, and compare the CBCT based isocenter shifts among liver, lung and spine lesions. Material and Methods: 119 SBRT fractions wer ... Full text Cite

TH‐D‐M100F‐01: An Evaluation of Noise in Radiotracer Emission Imaging Using Flat‐Panel Detectors

Conference Medical Physics · January 1, 2007 Purpose: Single Photon Emission Computed Tomography (SPECT) onboard radiation therapy machines could enable the use of functional and molecular imaging in guiding the therapy beam and in monitoring disease. Costs and spatial constraints of onboard SPECT mi ... Full text Cite

TH‐E‐M100F‐07: Amplitude Gated Breath‐Hold Treatment for Upper Abdominal Lesions with On Board Imaging Guidance

Conference Medical Physics · January 1, 2007 Purpose: To apply on‐boardmdash;image (OBI) guided amplitude gating for breath‐hold treatment and to assess treatment margin adequacy by analyzing the isocenter placement based on orthogonal 2D kV radiographs and 3D cone‐beam CT (CBCT) acquired under ampli ... Full text Cite

Outcomes in a series of 103 retroperitoneal sarcomas.

Journal Article Eur J Surg Oncol · December 2006 AIMS: To report the effect on outcome of selection in patients receiving intra-operative electron beam radiation (IOERT) and external beam radiation therapy (EBRT). METHODS: One hundred and three patients treated for primary RS were studied. Median follow- ... Full text Link to item Cite

Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: theory and clinical practice.

Journal Article Semin Oncol · October 2006 Despite the routine use of adjuvant and neoadjuvant chemoradiotherapy, patients with advanced rectal tumors experience significant rates of treatment failure and disease recurrence. Resistance to radiation is a particular problem. Adding a vascular endothe ... Full text Link to item Cite

Phase II trial of preoperative chemoradiation in patients with localized gastric adenocarcinoma (RTOG 9904): quality of combined modality therapy and pathologic response.

Journal Article J Clin Oncol · August 20, 2006 PURPOSE: Preoperative therapy for localized gastric cancer has considerable appeal. We hypothesized that, in a cooperative group setting, preoperative chemoradiotherapy would induce a 20% pathologic complete response (pathCR) rate. Combined-modality therap ... Full text Link to item Cite

Concurrent cisplatin, 5-FU, paclitaxel, and radiation therapy in patients with locally advanced esophageal cancer.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2006 PURPOSE: Phase I-II data regarding neoadjuvant cisplatin, 5-fluorouracil (5-FU), paclitaxel, and radiation (PFT-R) from our institution demonstrated encouraging pathologic complete response (pCR) rates. This article updates our experience with PFT-R, and c ... Full text Link to item Cite

Radiation therapy in the treatment of cholangiocarcinoma.

Journal Article Oncology (Williston Park) · July 2006 The prognosis of patients with biliary cancers is poor. Although surgery is potentially curative in selected patients, local recurrence is a common pattern of failure. Adjuvant or neoadjuvant radiation therapy improves local control and possibly survival. ... Link to item Cite

Digital tomosynthesis with an on-board kilovoltage imaging device.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2006 PURPOSE: To generate on-board digital tomosynthesis (DTS) and reference DTS images for three-dimensional image-guided radiation therapy (IGRT) as an alternative to conventional portal imaging or on-board cone-beam computed tomography (CBCT). METHODS AND MA ... Full text Link to item Cite

Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy.

Journal Article J Clin Oncol · March 20, 2006 PURPOSE: Circulating endothelial cells (CECs) and progenitor cells are currently evaluated as potential biomarkers of antiangiogenic therapy. CD146 is considered a panendothelial-specific marker, but its utility as a CEC marker in cancer patients remains u ... Full text Link to item Cite

Radiation therapy for resectable colon cancer. Is there a role in the modern chemotherapy era?

Journal Article Oncology (Williston Park) · February 2006 Colon cancer is a major public health problem. The primary treatment is resection. For patients with early-stage disease, surgery results in excellent survival rates. In contrast, patients with locally advanced tumors arising in "anatomically immobile" seg ... Link to item Cite

Increased toxicity with gefitinib, capecitabine, and radiation therapy in pancreatic and rectal cancer: phase I trial results.

Journal Article J Clin Oncol · February 1, 2006 PURPOSE: Overexpression of epidermal growth factor receptor (EGFR) has been associated with aggressive tumor phenotypes, chemotherapy, and radiation resistance, as well as poor survival in preclinical and clinical models. The EGFR inhibitor gefitinib poten ... Full text Link to item Cite

Pancreatoblastoma in a teenage patient.

Journal Article Clin Adv Hematol Oncol · February 2006 Link to item Cite

Randomized phase II study of neoadjuvant combined-modality chemoradiation for distal rectal cancer: Radiation Therapy Oncology Group Trial 0012.

Journal Article J Clin Oncol · February 1, 2006 PURPOSE: To evaluate the rate of pathologic complete response and toxicity of neoadjuvant chemoradiation for advanced T3/T4 distal rectal cancers in a randomized phase II study PATIENTS AND METHODS: Patients with clinical T3/T4 distal rectal cancers were r ... Full text Link to item Cite

Detection of stool DNA mutations before and after treatment of colorectal neoplasia.

Journal Article Cancer · January 15, 2006 BACKGROUND: Whether stool DNA abnormalities arise solely from colorectal neoplastic lesions or are due to more pervasive field effects is not known. In the current study, the authors conducted a prospective multicenter study to evaluate the performance of ... Full text Link to item Cite

Upper gastrointestinal tract.

Journal Article Cancer Treat Res · 2006 Full text Link to item Cite

SU‐FF‐T‐66: A Technique for Cone‐Beam CT‐Guided Stereotactic Body Radiation Therapy

Conference Medical Physics · January 1, 2006 Purpose: To develop and assess a technique using cone‐beam CT (CBCT) to localize treatment targets for stereotactic body radiation therapy (SBRT). Material and Methods: Patients selected for SBRT had 3‐D or 4‐D CT simulation with immobilization. GTV, CTV, ... Full text Cite

TU‐FF‐A3‐02: Preliminary Investigations Into Combined CT/SPECT Imaging Onboard Therapy Machines

Conference Medical Physics · January 1, 2006 Purpose: Functional and molecular (F&M) imaging onboard radiation therapy machines would allow for targeting of functional tumor volume, and avoiding of healthy tissue, by guiding and modifying radiation beams, in the treatment room, based on real‐time F&M ... Full text Cite

SU‐EE‐A1‐04: Verifying Internal Target Volume Using Cone‐Beam CT for Stereotactic Body Radiotherapy Treatment

Conference Medical Physics · January 1, 2006 Purpose: The internal target volume (ITV) could be determined using 4D CT simulation images and be verified in the treatment room using on‐board cone‐beam CT (CBCT) since the CBCT projection images are acquired over approximately 10 breathing cycles. This ... Full text Cite

SU‐FF‐J‐86: Intra‐ and Inter‐Breath‐Hold Position Variations for OBI Guided Amplitude Gating Treatment with Breath Hold

Conference Medical Physics · January 1, 2006 Purpose: We have applied OBI guidance together with a respiratory gating system to effectively control patient positioning for amplitude gating treatment with breath hold. The deep inspiration breath‐hold treatment has been proven effective in reducing the ... Full text Cite

SU‐FF‐J‐16: A Tool for Off‐Line Review of 3D Target Verification and Localization with Cone‐Beam Computed Tomography

Conference Medical Physics · January 1, 2006 Purpose: To implement a clinical tool for off‐line review of Cone‐Beam Computed Tomography (CBCT) based 3D target verification and localization. Methods and Materials: An in‐house 3D target localization and verification tool is being developed to allow phy ... Full text Cite

SU‐FF‐J‐96: Modeling Correlation Between External Surface Motion and Internal Organ Motion Based On 4DCT

Conference Medical Physics · January 1, 2006 Purpose: To develop a method for modeling the dynamic relationship between patient surface motion and internal target motion using 4DCT data. Then, to verify its capability to interpolate internal target motion with real‐time patient surface motion informa ... Full text Cite

The Chadha/Kuvshinoff/Javle article reviewed

Journal Article ONCOLOGY · December 1, 2005 Cite

The Pisters/Wolff/Crane et al article reviewed

Journal Article ONCOLOGY · December 1, 2005 Cite

Adjuvant external-beam radiotherapy with concurrent chemotherapy after resection of primary gallbladder carcinoma: a 23-year experience.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2005 PURPOSE: Primary adenocarcinoma of the gallbladder is a rare malignancy. To better define the role of adjuvant radiation therapy and chemotherapy, a retrospective analysis of the outcome of patients undergoing surgery and adjuvant therapy was undertaken. M ... Full text Link to item Cite

Locally advanced pancreatic cancer.

Journal Article J Clin Oncol · July 10, 2005 Of the 32,180 patients diagnosed with pancreatic carcinoma in the United States this year, approximately 40% will present with locally advanced disease. Radiotherapeutic approaches are often employed because these patients have unresectable tumors by virtu ... Full text Link to item Cite

Outcome results of the 1996-1999 patterns of care survey of the national practice for patients receiving radiation therapy for carcinoma of the esophagus.

Journal Article J Clin Oncol · April 1, 2005 PURPOSE: A Patterns of Care Study of patients treated from 1996 to 1999 evaluated the national practice for patients receiving radiation therapy for carcinoma of the esophagus in the United States. METHODS: A national survey was conducted at 59 institution ... Full text Link to item Cite

Four-dimensional image-based treatment planning: Target volume segmentation and dose calculation in the presence of respiratory motion.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2005 PURPOSE: To describe approaches to four-dimensional (4D) treatment planning, including acquisition of 4D-CT scans, target delineation of spatio-temporal image data sets, 4D dose calculations, and their analysis. METHODS AND MATERIALS: The study included pa ... Full text Link to item Cite

The correlation between internal and external markers for abdominal tumors: implications for respiratory gating.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2005 PURPOSE: The correlation of the respiratory motion of external patient markers and abdominal tumors was examined. Data of this type are important for image-guided therapy techniques, such as respiratory gating, that monitor the movement of external fiducia ... Full text Link to item Cite

A challenge to the therapeutic nihilism of ESPAC-1.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2005 Full text Link to item Cite

Assessing tumor perfusion and treatment response in rectal cancer with multisection CT: initial observations.

Journal Article Radiology · March 2005 PURPOSE: To use first-pass perfusion computed tomography (CT) to prospectively investigate tumor vascularity in rectal cancer and to determine whether any of the perfusion parameters would predict tumor response to chemotherapy and radiation therapy. MATER ... Full text Link to item Cite

Long-term results of intraoperative electron beam irradiation (IOERT) for patients with unresectable pancreatic cancer.

Journal Article Ann Surg · February 2005 SUMMARY BACKGROUND DATA: To analyze the effects of a treatment program of intraoperative electron beam radiation therapy (IOERT) and external beam radiation therapy and chemotherapy on the outcome of patients with unresectable or locally advanced pancreati ... Full text Link to item Cite

Combined modality treatment for rectal cancer.

Journal Article Semin Oncol · February 2005 Significant gains have been achieved in the integration of radiation therapy (RT) and chemotherapy with surgery in the management of patients with localized rectal cancer. Treatment combinations of RT and chemotherapy with surgery have evolved to neoadjuva ... Full text Link to item Cite

Patients undergoing treatment for pancreatic adenocarcinoma can mount an effective immune response to vaccinations.

Journal Article Pancreatology · 2005 BACKGROUND: Immunotherapy has been proposed as a novel treatment for pancreatic cancer. However, patients with pancreatic cancer have been observed to have depressed immune responses, suggesting that immunotherapy might have limited utility in this group o ... Full text Link to item Cite

SU‐FF‐J‐30: Quantification of Normal Organ Motion Due to the Respiratory and Cardiac Cycles

Conference Medical Physics · January 1, 2005 Purpose: To quantify the degree of normal organ motion due to the respiratory and cardiac cycles. Better definition of such motion may be useful in defining field margins and in assessing the utility of gating technologies. Method and Materials: Four healt ... Full text Cite

SU‐EE‐A4‐04: Compartment Modeling Analysis of Cu‐ATSM Dynamic PET Images

Conference Medical Physics · January 1, 2005 Purpose: Copper labeled diacetyl‐bis(N4‐methylthiosemicarbazone) (Cu‐ATSM) has been reported to selectively bind to hypoxic tumor cells. This makes Cu‐ATSM PET a promising modality to image tumor hypoxia. However, intravascular Cu‐ATSM that is not related ... Full text Cite

Moving targets: detection and tracking of internal organ motion for treatment planning and patient set-up.

Journal Article Radiother Oncol · December 2004 BACKGROUND AND PURPOSE: Clinical target volumes of the thorax and abdomen are typically expanded to account for inter- and intrafractional organ motion. Usually, such expansions are based on clinical experience and planar observations of target motion duri ... Full text Link to item Cite

Adjuvant therapy for pancreatic cancer: an evolving paradigm.

Journal Article Surg Oncol Clin N Am · October 2004 Pancreatic cancer is the fourth leading cause of death in men and fifth in women in the United States. The median survival is 8 to 12 months for patients with locally advanced and unresectable disease and only 3 to 6 months for those with metastatic diseas ... Full text Link to item Cite

Phase III study of adjuvant chemotherapy and radiation therapy compared with chemotherapy alone in the surgical adjuvant treatment of colon cancer: results of intergroup protocol 0130.

Journal Article J Clin Oncol · August 15, 2004 PURPOSE: Some patients with colon cancer have a high risk of local recurrence postoperatively. This trial was undertaken to determine whether radiation therapy added to an adjuvant chemotherapy regimen improves outcome in high-risk patients. PATIENTS AND M ... Full text Link to item Cite

Impact of T and N stage and treatment on survival and relapse in adjuvant rectal cancer: a pooled analysis.

Journal Article J Clin Oncol · May 15, 2004 PURPOSE: To determine survival and relapse rates by T and N stage and treatment method in five randomized phase III North American rectal adjuvant studies. PATIENTS AND METHODS: Data were pooled from 3,791 eligible patients enrolled onto North Central Canc ... Full text Link to item Cite

Quantification of respiration-induced abdominal tumor motion and its impact on IMRT dose distributions.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2004 PURPOSE: The treatment of moving targets with intensity-modulated radiotherapy may introduce errors in dose delivery. The motion of tumors in the abdomen was studied using quantitative fluoroscopic analysis, and the effect on dose delivery to the target wa ... Full text Link to item Cite

Impact of body mass index on outcomes and treatment-related toxicity in patients with stage II and III rectal cancer: findings from Intergroup Trial 0114.

Journal Article J Clin Oncol · February 15, 2004 PURPOSE: To study the relationship between body mass index (BMI) and rates of sphincter-preserving operations, overall survival, cancer recurrence, and treatment-related toxicities in patients with rectal cancer. PATIENTS AND METHODS: We evaluated a nested ... Full text Link to item Cite

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer.

Journal Article Nat Med · February 2004 The effects of vascular endothelial growth factor (VEGF) blockade on the vascular biology of human tumors are not known. Here we show here that a single infusion of the VEGF-specific antibody bevacizumab decreases tumor perfusion, vascular volume, microvas ... Full text Link to item Cite

Impact of hospital procedure volume on surgical operation and long-term outcomes in high-risk curatively resected rectal cancer: findings from the Intergroup 0114 Study.

Journal Article J Clin Oncol · January 1, 2004 PURPOSE: Prior studies have demonstrated superior outcomes after a curative surgical resection of rectal cancer at hospitals where the volume of such surgeries is high. However, because these studies often lack detailed information on tumor and treatment c ... Full text Link to item Cite

Update on combined-modality treatment options for pancreatic cancer.

Journal Article Oncology (Williston Park) · December 2003 Cancer of the pancreas remains a formidable challenge in oncology. This malignancy ranks as the fourth leading cause of cancer death in the United States in 2003, with an estimated 30,700 new cases to be diagnosed and 30,000 deaths. Although gains have bee ... Link to item Cite

Intraoperative radiation therapy in the management of gynecologic and genitourinary malignancies.

Journal Article Surg Oncol Clin N Am · October 2003 Women with locally advanced primary or recurrent gynecologic malignancies have a poor prognosis. The doses of external radiation necessary to treat gross or microscopic recurrent disease in patients previously irradiated exceed the doses tolerated by norma ... Full text Link to item Cite

Clinical physics, applicator choice, technique, and equipment for electron intraoperative radiation therapy.

Journal Article Surg Oncol Clin N Am · October 2003 IORT has been a widely used modality since the 1980s. The initial euphoria experienced at the beginning, however, has subsided, with the result that most centers still practicing IORT are academic institutions. The reason for the reduction in IORT performe ... Full text Link to item Cite

Chemotherapeutic and biologic agents as radiosensitizers in rectal cancer.

Journal Article Semin Radiat Oncol · October 2003 Over the past 25 years, important advances have been made in the management of patients with resectable rectal cancer. Clinical studies have shown the efficacy of combined chemoradiation therapy in enhancing resectability and sphincter preservation rates, ... Full text Link to item Cite

Advances in combined radiation therapy for the management of rectal cancer.

Journal Article Expert Rev Anticancer Ther · August 2003 Significant advances have been made in the use of adjuvant radiation for patients with localized rectal cancer. Recent progress in adjuvant postoperative radiation regimens relates to the integration of systemic therapy into radiation, as well as redefinin ... Full text Link to item Cite

Combined modality therapy for rectal and colon cancer.

Journal Article Semin Oncol · August 2003 Combined modality therapy (CMT) with radiation therapy and chemotherapy plays an important role in the management of rectal cancer. Postoperatively, pelvic irradiation and 5-fluorouracil-based chemotherapy have been used to improve local control and surviv ... Full text Link to item Cite

The national practice for patients receiving radiation therapy for carcinoma of the esophagus: results of the 1996-1999 Patterns of Care Study.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2003 PURPOSE: A Patterns of Care Study (PCS) was conducted to evaluate the standards of practice for patients receiving radiation therapy for esophageal cancer from 1996 to 1999. This study examined the evaluation and treatment schemes used during this time and ... Full text Link to item Cite

Adjuvant Therapy of Rectal Cancer: Introduction

Journal Article Seminars in Radiation Oncology · January 1, 2003 Full text Cite

Clinical research in pancreatic cancer: the Radiation Therapy Oncology Group trials.

Journal Article Int J Radiat Oncol Biol Phys · 2003 To summarize the clinical research activities of the Radiation Therapy Oncology Group program in the treatment of patients with locally advanced, as well as resected, pancreatic cancer. Phase II and III clinical trials are underway, examining novel cytotox ... Full text Link to item Cite

Results of radiation therapy in gastric cancer.

Journal Article Semin Radiat Oncol · April 2002 Radiation therapy has been used in the treatment of patients with gastric cancer in two clinical settings: definitive therapy for locally advanced, unresectable tumors and adjuvant therapy following surgery for high-risk disease. For patients with locally ... Full text Link to item Cite

Management of locally advanced adenocarcinoma of the pancreas.

Journal Article Hematol Oncol Clin North Am · February 2002 Pancreatic cancer is one of the deadliest malignancies and is fatal in more than 95% of affected individuals. For locally advanced disease, the combination of 5-FU and radiation appears to offer the best chance for delaying disease progression. The introdu ... Full text Link to item Cite

Gastric surgical adjuvant radiotherapy consensus report: rationale and treatment implementation.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2002 Radiation therapy has recently emerged as a pivotal modality in the management of completely resected, high-risk gastric cancer. The recently published results of the Intergroup 0116 Gastric Surgical Adjuvant Trial randomized high-risk (T3,4 and/or node po ... Full text Link to item Cite

Local excision of rectal cancer

Journal Article Seminars in Colon and Rectal Surgery · December 1, 2001 The treatment of distal rectal cancer is in evolution. Although abdominoperineal resection has been long regarded as the definitive treatment of distal rectal cancer, it is associated with significant morbidity loss of anorectal function with a permanent c ... Cite

Adjuvant radiation therapy for colon carcinoma

Journal Article Seminars in Colon and Rectal Surgery · December 1, 2001 Although the benefit of adjuvant chemotherapy in high-risk carcinoma of the colon after surgical resection has been shown through randomized trials, the role of external beam radiotherapy is uncertain. Historic studies on patterns and predictors of failure ... Cite

Intraoperative radiation therapy.

Journal Article Int J Clin Oncol · October 2001 The modern use of intraoperative radiation therapy (IORT) was initiated by the studies of Abe and colleagues at the University of Kyoto. This work stimulated significant laboratory and clinical investigation into the use of IORT throughout Japan, Europe, a ... Full text Link to item Cite

Radiation therapy in the management of rectal cancer.

Journal Article Curr Opin Oncol · July 2001 Substantial advances have been made in the adjuvant management of patients with resectable rectal cancer. Increasing interest in patient quality of life has promoted the use of radiation therapy to enhance sphincter-preserving surgical approaches as an alt ... Full text Link to item Cite

Effect of ionizing radiation on thymidine uptake, differentiation, and VEGFR2 receptor expression in endothelial cells: the role of VEGF(165).

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2001 PURPOSE: Late thrombosis of irradiated vascular segments may be the consequence of endothelial cell (EC) dysfunction after radiation therapy. We investigated the effects of beta ionizing radiation on human EC viability, thymidine uptake, and differentiatio ... Full text Link to item Cite

Squamous cell carcinoma of the anal canal and anal margin.

Journal Article Hematol Oncol Clin North Am · April 2001 Squamous cell carcinomas of the anal canal and margin are relatively uncommon neoplasms of the distal gastrointestinal tract and surrounding skin. The major risk factors for tumor development have been defined through various epidemiologic studies. Randomi ... Full text Link to item Cite

Intraoperative radiation therapy for locally advanced recurrent rectal or rectosigmoid cancer.

Journal Article Radiother Oncol · January 2001 BACKGROUND AND PURPOSE: To update and summarize the experience at the Massachusetts General Hospital of a treatment program of high-dose preoperative irradiation, surgical re-resection, and intraoperative radiation therapy (IORT) as a salvage treatment for ... Full text Link to item Cite

Gastrointestinal cancer committee

Journal Article International Journal of Radiation Oncology Biology Physics · 2001 Cite

Sphincter preservation in rectal cancer.

Journal Article Curr Treat Options Oncol · December 2000 Distal rectal cancer poses two challenges to the oncologist: local tumor control and sphincter preservation. The abdominoperineal resection (APR), long considered the standard treatment of tumors with a distal edge located up to 6 cm from the anal verge, p ... Full text Link to item Cite

Current perspectives on locally advanced pancreatic cancer.

Journal Article Oncology (Williston Park) · November 2000 This year, approximately 40% of the 28,300 patients diagnosed with pancreatic carcinoma in the United States will present with locally advanced disease. Radiotherapeutic approaches are often employed, as these patients have unresectable tumors by virtue of ... Link to item Cite

Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999.

Journal Article Arch Pathol Lab Med · July 2000 BACKGROUND: Under the auspices of the College of American Pathologists, the current state of knowledge regarding pathologic prognostic factors (factors linked to outcome) and predictive factors (factors predicting response to therapy) in colorectal carcino ... Full text Link to item Cite

Impact of laparoscopic staging in the treatment of pancreatic cancer.

Journal Article Arch Surg · April 2000 HYPOTHESIS: Staging laparoscopy in patients with pancreatic cancer identifies unsuspected metastases, allows treatment selection, and helps predict survival. DESIGN: Inception cohort. SETTING: Tertiary referral center. PATIENTS: A total of 125 consecutive ... Full text Link to item Cite

Acute and late toxicity of patients with inflammatory bowel disease undergoing irradiation for abdominal and pelvic neoplasms.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2000 PURPOSE: Little data exists in the medical literature describing the response of patients with inflammatory bowel disease (IBD) to abdominal and pelvic irradiation. To clarify the use of this modality in this setting, this study assesses the short- and lon ... Full text Link to item Cite

Outcome of patients receiving radiation for cancer of the esophagus: results of the 1992-1994 Patterns of Care Study.

Journal Article J Clin Oncol · February 2000 PURPOSE: A Patterns of Care Study examined the records of patients with esophageal cancer (EC) treated with radiation in 1992 through 1994 to determine the national practice processes of care and outcomes and to compare the results with those of clinical t ... Full text Link to item Cite

Intraoperative radiation therapy in resected bile duct cancer.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2000 Full text Link to item Cite

Technical advances in the treatment of patients with rectal cancer.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 1999 Full text Link to item Cite

CD10/neutral endopeptidase inhibition augments pulmonary neuroendocrine cell hyperplasia in hamsters treated with diethylnitrosamine and hyperoxia.

Journal Article Am J Respir Cell Mol Biol · July 1999 In previous studies, we demonstrated that pulmonary neuroendocrine cell (PNEC) hyperplasia in hamsters treated with diethylnitrosamine (DEN) plus 65% hyperoxia (DEN/O2) reflects predominantly neuroendocrine cell differentiation. Several peptides implicated ... Full text Link to item Cite

Long-term follow-up of patients with rectal cancer managed by local excision with and without adjuvant irradiation.

Journal Article Ann Surg · July 1999 OBJECTIVE: The long-term outcomes of patients undergoing local excision with or without pelvic irradiation were examined to define the role of adjuvant irradiation after local excision of T1 and T2 rectal cancers. METHODS: Ninety-nine patients with T1 or T ... Full text Link to item Cite

The evaluation and treatment of patients receiving radiation therapy for carcinoma of the esophagus: results of the 1992-1994 Patterns of Care Study.

Journal Article Cancer · June 15, 1999 BACKGROUND: For the first time, a Patterns of Care Study (PCS) was conducted in 1992-1994 to determine the national practice standards in evaluating and treating patients with esophageal carcinoma and to determine the degree to which clinical trials have b ... Full text Link to item Cite

Prognostic factors in stage T3N0 rectal cancer: do all patients require postoperative pelvic irradiation and chemotherapy?

Journal Article Dis Colon Rectum · February 1999 PURPOSE: To further define the indications for postoperative pelvic irradiation and chemotherapy, an analysis of the influence of extent of tumor invasion into perirectal fat, lymphatic or venous vessel invasion, and tumor grade on the clinical course of p ... Full text Link to item Cite

Irradiation for Unresectable Pancreatic Cancer

Journal Article Journal of Gastrointestinal Surgery · January 1, 1999 Full text Cite

Does postoperative irradiation play a role in the adjuvant therapy of stage T4 colon cancer?

Journal Article Cancer J Sci Am · 1999 PURPOSE: This study analyzes the long-term outcome of patients with stage T4 colon cancer who receive postoperative irradiation. The purpose of the study is to define the potential role of this modality with current systemic therapies. PATIENTS AND METHODS ... Link to item Cite

Intraoperatic electron beam irradiation in pancreatic cancer.

Journal Article Front Biosci · November 15, 1998 Intraoperative electron beam radiation therapy (IOERT) is a technique in which a single high fraction radiation treatment is administered at the time of surgery. Using IOERT, the total radiation dose delivered to a tumor can be increased since sensitive no ... Full text Link to item Cite

The impact of 5-fluorouracil and intraoperative electron beam radiation therapy on the outcome of patients with locally advanced primary rectal and rectosigmoid cancer.

Journal Article Ann Surg · August 1998 OBJECTIVE: To analyze the effects of 5-fluorouracil (5-FU) chemotherapy combined with preoperative irradiation and the role of intraoperative electron beam irradiation (IOERT) on the outcome of patients with primary locally advanced rectal or rectosigmoid ... Full text Link to item Cite

Radiation therapy for rectosigmoid and rectal cancer: results of the 1992-1994 Patterns of Care process survey.

Journal Article J Clin Oncol · July 1998 PURPOSE: To determine the US national practice standards for patients with adenocarcinoma of the rectum treated in radiation oncology facilities. MATERIALS AND METHODS: A national survey of 57 institutions identified 507 eligible patients who received radi ... Full text Link to item Cite

Macrophage-stimulating protein and its receptor in non-small-cell lung tumors: induction of receptor tyrosine phosphorylation and cell migration.

Journal Article Am J Respir Cell Mol Biol · April 1998 Previously, we identified macrophage-stimulating protein (MSP) as being expressed during hamster lung injury induced by nitrosamine carcinogens. Transient, generalized epithelial-cell hyperplasia during the preneoplastic period, and eventually nonneuroendo ... Full text Link to item Cite

Implications of peritoneal cytology for pancreatic cancer management.

Journal Article Arch Surg · April 1998 OBJECTIVE: To assess the implications of positive cytology for malignant cells (positive results) from peritoneal washings in the management of patients with pancreatic cancer. DESIGN: Retrospective cohort study. SETTING: Referral practice in a university ... Full text Link to item Cite

Treatment systems guidelines for primary rectal cancer from the 1996 Patterns of Care Study.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 1998 PURPOSE: The Patterns of Care Rectal Cancer Committee was formed to develop consensus recommendations for patients with adenocarcinoma of the rectum limited to the pelvis. METHODS AND MATERIALS: The Committee was composed of a multidisciplinary group of on ... Full text Link to item Cite

Patterns of care study decision tree and management guidelines for esophageal cancer. American College of Radiology.

Journal Article Radiat Med · 1998 PURPOSE: The Patterns of Care Study (PCS) of the American College of Radiology periodically develops a decision tree and current management guidelines for major malignancies where radiation has an important role. The decision tree is a framework which depi ... Link to item Cite

Changes in tumor proliferation of rectal cancer induced by preoperative 5-fluorouracil and irradiation.

Journal Article Dis Colon Rectum · January 1998 PURPOSE: This study examines the effect of 5-fluorouracil administration during preoperative irradiation on rectal cancer tumor proliferation. PATIENTS AND METHODS: One hundred and fifty-three patients with locally advanced rectal cancer received 45 to 50 ... Full text Link to item Cite

Sphincter preservation in rectal cancer. Local excision followed by postoperative radiation therapy.

Journal Article Semin Radiat Oncol · January 1998 The management of distal rectal cancer is in evolution. Although abdominoperineal resection has been long regarded as the definitive treatment of distal rectal cancer, it is associated with significant morbidity--loss of anorectal function with a permanent ... Full text Link to item Cite

Intraoperative irradiation: current and future status.

Journal Article Semin Oncol · December 1997 Intraoperative radiation therapy (IORT) in its broadest sense refers to the delivery of irradiation at the time of an operation. This article will discusses the rationale for and results of both intraoperative electron radiation therapy and intraoperative ... Link to item Cite

NCCN practice guidelines for pancreatic cancer.

Journal Article Oncology (Williston Park) · November 1997 Link to item Cite

Time-dose considerations in the treatment of anal cancer.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 1997 PURPOSE: To analyze the impact of patient and treatment parameters in concurrent chemoradiation treatment for anal carcinoma. METHODS AND MATERIALS: Retrospective review of 50 MO anal cancer patients treated from 1984-1994. Most patients received concurren ... Full text Link to item Cite

Appendiceal carcinoma: patterns of failure following surgery and implications for adjuvant therapy.

Journal Article J Surg Oncol · September 1997 BACKGROUND AND OBJECTIVES: Primary adenocarcinoma of the appendix is rare, which makes an understanding of its natural history difficult. To date, it is treated predominantly with surgery alone. This review aims to elucidate the patterns of failure and tre ... Full text Link to item Cite

Adjuvant therapy for colorectal cancer.

Journal Article Curr Probl Surg · August 1997 Full text Link to item Cite

Differential screening of a human chromosome 3 library identifies hepatocyte growth factor-like/macrophage-stimulating protein and its receptor in injured lung. Possible implications for neuroendocrine cell survival.

Journal Article J Clin Invest · June 15, 1997 Transient pulmonary neuroendocrine cell hyperplasia and non-neuroendocrine lung tumors develop in nitrosaminetreated hamsters, which we hypothesized might modulate epithelial cell phenotype by expressing gene(s) homologous to human chromosome 3p gene(s) de ... Full text Link to item Cite

High risk of breast carcinoma after irradiation of young women with Hodgkin's disease.

Journal Article Cancer · March 15, 1997 BACKGROUND: Treatment-associated second neoplasms have emerged as a major threat to the continued survival of patients cured of Hodgkin's disease. In this study, the authors investigated the risk of breast carcinoma in an irradiated Hodgkin's disease popul ... Full text Link to item Cite

Adjuvant therapy for colorectal cancer background and results of surgical resection

Journal Article Current Problems in Surgery · January 1, 1997 Cite

The role of radiation therapy and 5-fluorouracil in colon and rectal cancer

Journal Article Seminars in Radiation Oncology · January 1, 1997 Since the original report of improved survival of patients with locally unresectable gastric cancer treated with irradiation and 5-fluorouracil (5- FU) in 1968, there has been extensive investigation of this treatment combination in a variety of gastrointe ... Full text Cite

CA 19-9 is an index of response to neoadjunctive chemoradiation therapy in pancreatic cancer.

Journal Article Am J Surg · October 1996 PURPOSE: This study examines the changes of serum levels of CA 19-9 in patients with pancreatic cancer following neoadjuvant irradiation and chemotherapy to define the potential role of this tumor marker in preoperative management of these patients. MATERI ... Full text Link to item Cite

Organ preservation in anal and rectal cancers.

Journal Article Curr Opin Oncol · July 1996 For the past 10 to 15 years, radiation therapy and chemotherapy have played an increasingly important role in the treatment of various gastrointestinal malignancies, most prominently in anal and rectal cancer. Critical issues in the care of patients with a ... Full text Link to item Cite

Intraoperative radiation therapy for locally advanced recurrent rectal or rectosigmoid cancer.

Journal Article J Surg Oncol · October 1995 Recurrent rectal or rectosigmoid cancer is a difficult therapeutic problem. A treatment program of external beam irradiation, surgery, and intraoperative irradiation has been used for 41 patients. The 5-year actuarial local control and disease-free surviva ... Full text Link to item Cite

Histochemical characterization of non-neuroendocrine tumors and neuroendocrine cell hyperplasia induced in hamster lung by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone with or without hyperoxia.

Journal Article Am J Pathol · September 1995 Lung tumors induced by 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone (NNK) with or without hyperoxia have frequent K-ras mutations but only rare p53 mutations, suggesting that this may be a model for non-small cell lung cancers. The goals of the present s ... Link to item Cite

Tumor proliferation in rectal cancer following preoperative irradiation.

Journal Article J Clin Oncol · June 1995 PURPOSE: This study examines the effect of preoperative irradiation on tumor proliferation in rectal cancer. PATIENTS AND METHODS: One hundred twenty-two patients with locally advanced rectal cancer received 45 to 50 Gy of preoperative irradiation followed ... Full text Link to item Cite

Rectal cancer: the influence of tumor proliferation on response to preoperative irradiation.

Journal Article Int J Radiat Oncol Biol Phys · April 30, 1995 PURPOSE: Regression of rectal carcinoma after preoperative irradiation is variable, likely reflecting differences in the physical and biologic properties of these tumors. This study examines the association between the pathologic response of rectal cancer ... Full text Link to item Cite

Modulation of oncogene and tumor suppressor gene expression in a hamster model of chronic lung injury with varying degrees of pulmonary neuroendocrine cell hyperplasia.

Journal Article Lab Invest · June 1994 BACKGROUND: Intense pulmonary neuroendocrine cell (PNEC) hyperplasia occurs during preneoplastic lung injury in hamsters treated with diethylnitrosamine (DEN) plus hyperoxia. Alterations in oncogene and tumor suppressor gene expression during this process ... Link to item Cite

The effect of pelvic radiation therapy on serum levels of prostate specific antigen.

Journal Article J Urol · June 1994 To determine the effect of prostatic irradiation on the production of prostate specific antigen (PSA), serum PSA levels were measured in 36 men who received pelvic irradiation (45 to 65 Gy.) for nonprostatic malignancies, and compared with those of a contr ... Full text Link to item Cite

Selection factors for local excision or abdominoperineal resection of early stage rectal cancer.

Journal Article Cancer · June 1, 1994 BACKGROUND: This study reviews the experience of patients with early stage rectal cancer managed by local excision or abdominoperineal resection to clarify the relative indications and results of these two approaches. METHODS: From 1962 to 1991, 125 patien ... Full text Link to item Cite

Proliferating cell nuclear antigen and mitotic activity in rectal cancer: predictor of response to preoperative irradiation.

Journal Article J Clin Oncol · April 1994 PURPOSE: This study examines the association between the pathologic response of rectal cancer after irradiation and its pretreatment proliferative state as assayed by proliferating cell nuclear antigen (PCNA) and mitotic activity. PATIENTS AND METHODS: Nin ... Full text Link to item Cite

Radical radiation therapy in the management of prostatic adenocarcinoma: the initial prostate specific antigen value as a predictor of treatment outcome.

Journal Article J Urol · March 1994 We studied 161 prostate cancer patients treated by radical irradiation alone without endocrine therapy in whom pretreatment and posttreatment prostate specific antigen (PSA) values were measured, and who had a minimum followup of 2 years. Outcome was analy ... Full text Link to item Cite

Chemoradiotherapy for anal carcinoma: What is the optimal radiation dose?

Journal Article Radiation Oncology Investigations · January 1, 1994 A dose‐response analysis was undertaken in a group of patients with clinically node‐negative carcinoma of the anal canal treated with a sphincter‐sparing approach. Twenty‐three patients underwent biopsy of the primary tumor, followed by concurrent radiatio ... Full text Cite

Late rectal bleeding following combined X-ray and proton high dose irradiation for patients with stages T3-T4 prostate carcinoma.

Journal Article Int J Radiat Oncol Biol Phys · June 15, 1993 PURPOSE: Dose escalation for prostate cancer by external beam irradiation is feasible by a 160 MeV perineal proton beam that reduces the volume of rectum irradiated. We correlated the total doses received to portions of the anterior rectum to study the pos ... Full text Link to item Cite

Postoperative radiation therapy for high-risk colon carcinoma.

Journal Article J Clin Oncol · June 1993 PURPOSE: This study examines the experience of patients treated with postoperative radiation therapy after resection of high-risk colon carcinoma in an effort to assess the potential role of this modality in combination with current systemic therapies. PAT ... Full text Link to item Cite

A phase I/II study of intraoperative radiotherapy in advanced unresectable or recurrent carcinoma of the rectum: a Radiation Therapy Oncology Group (RTOG) study.

Journal Article J Surg Oncol · May 1993 The Radiation Therapy Oncology Group (RTOG) initiated a phase I/II study of intraoperative radiotherapy (IORT) in advanced or recurrent rectal cancer to assess therapeutic efficacy, toxicity, and establish quality control guidelines prior to beginning a ph ... Full text Link to item Cite

Resection margins in carcinoma of the head of the pancreas. Implications for radiation therapy.

Journal Article Ann Surg · February 1993 A retrospective review of the pathology and clinical course of 72 patients undergoing resection of carcinoma of the head of the pancreas was undertaken to identify the frequency of tumor involvement at standard surgical transection margins (stomach, duoden ... Full text Link to item Cite

Residual disease after radical surgery or radiation therapy for prostate cancer. Clinical significance and therapeutic implications.

Journal Article Cancer · February 1, 1993 Radical treatment for prostate cancer aims at complete eradication of tumor. This review of published data makes clear that the goal is less frequently achieved than commonly presumed. Following radical prostatectomy extracapsular disease, carrying a signi ... Full text Link to item Cite

Adjuvant postoperative radiation therapy for colonic carcinoma

Journal Article Seminars in Radiation Oncology · January 1, 1993 Full text Cite

Patterns of failure after pancreaticoduodenectomy for ampullary carcinoma.

Journal Article Surg Gynecol Obstet · January 1993 The clinical courses of 41 patients with ampullary carcinoma were retrospectively reviewed to determine patterns of failure after resection. The five year actuarial local control and overall survival rates of 29 patients undergoing only pancreaticoduodenec ... Link to item Cite

Adjuvant postoperative radiation therapy for rectal adenocarcinoma.

Journal Article Am J Clin Oncol · October 1992 From October 1975 to August 1988, 261 patients at high risk for local recurrence after curative resection of rectal carcinoma underwent high-dose postoperative irradiation. Patients received 45 Gy by a 4-field box usually followed by a boost to 50.4 Gy or ... Full text Link to item Cite

Prophylaxis for heterotopic bone formation after total hip arthroplasty using low-dose radiation in high-risk patients.

Journal Article Clin Orthop Relat Res · July 1992 Fifteen consecutive total hip arthroplasties (THAs) in 14 patients considered at risk for developing significant heterotopic ossification (HO) were treated postoperatively with 7.5 Gy of external beam radiation in three fractions. Eight hips in eight of th ... Link to item Cite

Induction and spontaneous regression of intense pulmonary neuroendocrine cell differentiation in a model of preneoplastic lung injury

Journal Article Cancer Research · May 1, 1992 Pulmonary neuroendocrine cell (PNEC) hyperplasia is associated with chronic lung diseases in humans, where it is thought to play a role in reparative responses to lung injury. To investigate the kinetics of strongly induced PNEC hyperplasia in an animal mo ... Cite

Are there patients with stage I rectal carcinoma at risk for failure after abdominoperineal resection?

Journal Article Cancer · April 1, 1992 The clinical courses of 64 patients undergoing abdominoperineal resection for Stage I lower rectal carcinoma (tumors confined to the muscularis propria without lymph node involvement) were reviewed to identify subsets at risk for failure. Twelve of 12 pati ... Full text Link to item Cite

3-D comparative study of proton vs. x-ray radiation therapy for rectal cancer.

Journal Article Int J Radiat Oncol Biol Phys · 1992 To assess the usefulness of proton beams for treatment of patients with rectal cancer, we have performed comparative 3D treatment planning for proton beam and x-ray beam therapy. Three common x-ray techniques (AP-PA, 3-field, and 4-field box), a proton bea ... Full text Link to item Cite

The accelerated repopulation of a murine fibrosarcoma, FSA-II, during the fractionated irradiation and the linear-quadratic model.

Journal Article Int J Radiat Oncol Biol Phys · November 1991 Radiation response of a spontaneous mouse fibrosarcoma, FSa-II, to various fractionated doses was studied in vivo together with single dose cell survival curves. Early generation isotransplants were used. Animals were C3Hf/Sed mice derived from our defined ... Full text Link to item Cite

Intraoperative electron beam radiation therapy for retroperitoneal soft tissue sarcoma.

Journal Article Cancer · July 15, 1991 From December 1981 to December 1989, 20 patients with primary or recurrent retroperitoneal sarcoma received 4000 to 5000 cGy of external beam radiation therapy (EBRT) in conjunction with surgical resection and intraoperative radiation therapy (IORT). Seven ... Full text Link to item Cite

Preoperative irradiation for tethered rectal carcinoma.

Journal Article Radiother Oncol · June 1991 Twenty-eight patients with resectable but tethered rectal carcinomas were treated with preoperative irradiation (EBRT) and surgical resection. The 5-year actuarial disease-free survival and local control rates of these 28 patients were 66 and 76%, respecti ... Full text Link to item Cite

Intraoperative electron beam radiation therapy for primary locally advanced rectal and rectosigmoid carcinoma.

Journal Article J Clin Oncol · May 1991 To improve local control and survival in patients with primary locally advanced rectal and rectosigmoid carcinoma, intraoperative electron beam radiation therapy (IORT) has been used with a combination of moderate- to high-dose preoperative radiation thera ... Full text Link to item Cite

Intraoperative electron beam radiation therapy for recurrent locally advanced rectal or rectosigmoid carcinoma.

Journal Article Cancer · March 15, 1991 A multimodality approach of moderate-dose to high-dose preoperative radiation therapy, surgical resection, and intraoperative electron beam radiation therapy (IORT) has been used for patients with locally recurrent rectal or rectosigmoid carcinoma. The 5-y ... Full text Link to item Cite

Radiation-blocking shields to localize periarticular radiation precisely for prevention of heterotopic bone formation around uncemented total hip arthroplasties.

Journal Article Clin Orthop Relat Res · August 1990 Sixteen patients (18 hips) were treated with localized radiation therapy limited to periarticular regions surrounding the femoral neck by shielding the prosthesis and the adjacent regions to prevent heterotopic bone formation around the uncemented prosthes ... Link to item Cite

Considerations in fractionated proton radiation therapy: clinical potential and results.

Journal Article Radiother Oncol · January 1990 Protons have a finite range in tissue and can provide a better concentration of radiation dose in the tumor than conventional X-rays in certain situations. The development of optimized treatment plans for X-rays and protons followed by a comparative evalua ... Full text Link to item Cite

Patterns of failure following local excision and local excision and postoperative radiation therapy for invasive rectal adenocarcinoma.

Journal Article J Clin Oncol · August 1989 The clinical course of 40 patients undergoing conservative surgical excision and 26 patients undergoing local excision and postoperative radiation therapy of rectal carcinoma was reviewed. Surgical procedures were transanal excision (55 patients), Kraske p ... Full text Link to item Cite

Indications for adjuvant radiotherapy in extrapelvic colonic carcinoma.

Journal Article Oncology (Williston Park) · July 1989 Although the value of postoperative radiotherapy has been demonstrated for subsets of patients with rectal carcinoma, the efficacy of postoperative radiation therapy for colonic carcinoma (above the peritoneal reflection) is much less clear. Recent studies ... Link to item Cite

Modulation of the transformed and neoplastic phenotype of rat fibroblasts by MHC-I gene expression.

Journal Article Cancer Res · June 15, 1989 Transfection of the activated ras oncogene (Ha-ras) into second passage rat embryo fibroblasts can induce the metastatic phenotype, while cotransfection of Ha-ras with the adenovirus type 2 E1a gene (Ad2-E1a) yields cells which are tumorigenic but nonmetas ... Link to item Cite

Altered growth of a human neuroendocrine carcinoma line after transfection of a major histocompatibility complex class I gene.

Journal Article Proc Natl Acad Sci U S A · June 1989 The major histocompatibility complex (MHC) class I molecules are known to serve as recognition elements for cytotoxic T cells in mediating the rejection of transplanted tumors. We demonstrate that MHC molecules may have nonimmune functions in modulating tu ... Full text Link to item Cite

Mediastinal large cell lymphoma. An uncommon subset of adult lymphoma curable with combined modality therapy.

Journal Article Cancer · November 1, 1988 Thirty adults with large cell lymphoma predominantly localized to the mediastinum diagnosed at the Massachusetts General Hospital between 1976 and 1985 were identified. The median age of the 20 females and 10 males was 34 years. All but one presented with ... Full text Link to item Cite

Partial suppression of anchorage-independent growth and tumorigenicity in immunodeficient mice by transfection of the H-2 class I gene H-2Ld into a human colon cancer cell line (HCT).

Journal Article Proc Natl Acad Sci U S A · November 1988 Many human tumors, particularly those of epithelial origin, appear to express greatly reduced levels of major histocompatibility complex class I antigens on their surface. It has been previously reported that the class I gene H-2Ld, introduced into adenovi ... Full text Link to item Cite

Effects of pentobarbital anesthesia on the energy metabolism of murine tumors studied by in vivo 31P nuclear magnetic resonance spectroscopy.

Journal Article Radiat Res · August 1988 The effects of pentobarbital anesthesia on the energy metabolism of FSaII and MCaIV foot tumors in mice were studied by 31P MRS. Using an 8.5 T spectrometer, in vivo spectra were obtained in 15 animals before and after pentobarbital anesthesia (0.05 mg/g i ... Link to item Cite

Three-dimensional volumetric assessment of response to treatment: stage I and II diffuse large cell lymphoma of the mediastinum.

Journal Article Radiother Oncol · July 1988 From 1981 to 1986, 12 patients with Stage I and II diffuse large cell lymphoma of the mediastinum were treated with 4 or more cycles of multiagent chemotherapy and for nine patients this was followed by mediastinal irradiation. The response to treatment wa ... Full text Link to item Cite

Stage IA to IIB mediastinal Hodgkin's disease: three-dimensional volumetric assessment of response to treatment.

Journal Article J Clin Oncol · May 1988 From 1979 to 1986, the response to treatment of 53 patients with stage IA to IIB mediastinal Hodgkin's disease was evaluated by three-dimensional volumetric analysis using thoracic computed tomographic (CT) scans. The mean initial volume of mediastinal dis ... Full text Link to item Cite

Adjuvant postoperative radiation therapy for colonic carcinoma.

Journal Article Ann Surg · December 1987 One hundred thirty-three patients with Stage B2, B3, and C colonic carcinoma had resection for curative intent followed by adjuvant postoperative radiotherapy to the tumor bed. The 5-year actuarial local control and disease-free survival rates for these 13 ... Full text Link to item Cite

Effects of oxygen on the metabolism of murine tumors using in vivo phosphorus-31 NMR.

Journal Article Am J Clin Oncol · December 1987 The effect of 100% inspired oxygen on in vivo tumor metabolism was examined using phosphorus-31 (31P) NMR spectroscopy. Isotransplants of two murine tumor histologies, designated MCaIV (C3H mammary adenocarcinoma) and FSaII (C3H fibrosarcoma), were used in ... Full text Link to item Cite

The histologic response of soft tissue sarcoma to radiation therapy.

Journal Article Cancer · October 1, 1987 Twenty-seven patients with soft tissue sarcoma had preoperative radiotherapy, limb-sparing marginal surgical resection and whole-mount tumor histologic analysis. Incisional biopsy specimens before radiotherapy were reviewed for tumor type, grade, and exten ... Full text Link to item Cite

The effect of the respiratory cycle on mediastinal and lung dimensions in Hodgkin's disease. Implications for radiotherapy gated to respiration.

Journal Article Cancer · September 15, 1987 Changes in mediastinal and lung dimensions during respiration were studied to assess the potential of radiotherapy gated to respiration to minimize normal tissue irradiation. Twelve patients with mediastinal Hodgkin's disease were assessed using chest radi ... Full text Link to item Cite

Effect of temperature on blood flow and hypoxic fraction in a murine fibrosarcoma.

Journal Article Int J Radiat Oncol Biol Phys · September 1987 The effect of hypo to hyperthermic temperatures on tumor blood flow and hypoxic cell fractions was studied in a murine fibrosarcoma transplanted in the hind leg of anesthetized mice. The blood flow to the tumor was assessed by the determination of the upta ... Full text Link to item Cite

Results of treatment of stage IA and IIA Hodgkin's disease.

Journal Article Cancer · March 15, 1987 This study analyzed the 5 year actuarial survival and disease-free survival of 122 patients with Stage IA and IIA Hodgkin's disease, (108 patients laparotomy staged) treated with mantle and paraaortic irradiation from 1975 to 1981. Prognostic subgroups and ... Full text Link to item Cite

Results of treatment of stage 3A Hodgkin's disease.

Journal Article Cancer · January 1, 1987 From 1975 to 1981, 38 patients with Stage 3A Hodgkin's disease (35 patients pathologically staged) underwent mantle and para-aortic irradiation, and in 36 patients this was preceded or followed by at least six cycles of multiagent chemotherapy. Both the 5- ... Full text Link to item Cite

Renal complications secondary to radiation treatment of upper abdominal malignancies.

Journal Article Int J Radiat Oncol Biol Phys · September 1986 A retrospective review of all patients undergoing radiotherapy for carcinoma of the colon, pancreas, stomach, small bowel and bile ducts, lymphomas of the stomach, and other GI sites and retroperitoneal sarcomas was completed to assess the effects of secon ... Full text Link to item Cite

Obstructive and perforative colonic carcinoma: patterns of failure.

Journal Article J Clin Oncol · March 1985 Carcinoma of the colon complicated by obstruction or perforation has been recognized as having a poorer prognosis than tumors without obstruction or perforation. To clarify the natural history, failure patterns, and implications for adjuvant treatment afte ... Full text Link to item Cite

Failure patterns following curative resection of colonic carcinoma.

Journal Article Ann Surg · December 1984 To identify patterns of failure following curative resection of colonic (nonrectal) carcinoma, the medical records of 533 patients undergoing resection with curative intent were reviewed. The overall local failure rate was 19% (102/533 patients) with 32 pa ... Full text Link to item Cite

Local failure following curative resection of colonic adenocarcinoma.

Journal Article Int J Radiat Oncol Biol Phys · May 1984 A retrospective review of the medical records of 533 patients undergoing resection with curative intent of large bowel above the peritoneal reflection was undertaken to identify subsets of patients at high risk for local failure. The overall local failure ... Full text Link to item Cite

The impact of coronary artery disease on carotid endarterectomy.

Journal Article Ann Surg · December 1983 In a series of 531 CENDX, preoperative cardiac risk was categorized by clinical criteria. Patients with CAD (history of previous MI, angina, congestive heart failure, and/or electrocardiographic evidence of CAD were selected for more invasive studies based ... Full text Link to item Cite

Effect of preoperative irradiation on resectability of colorectal carcinomas.

Journal Article Int J Radiat Oncol Biol Phys · August 1982 From 1968 to January 1, 1977, 44 patients with initially unresectable colorectal carcinoma were treated with preoperative radiotherapy and surgery. On presentation, unresectability was determined either clinically (26 patients) or by preradiotherapy laparo ... Full text Link to item Cite