Donald Benjamin Sanders

Conference Neuromuscular disorders : NMD · November 2024 The 275th ENMC workshop on the diagnosis and management of seronegative myasthenia gravis (SNMG) was held on February 9-11, 2024. The participants included experts in the field of adult and pediatric MG together with patient representatives. This workshop ... Full text Cite

Azathioprine and mycophenolate mofetil in myasthenia gravis - Authors' reply.

Journal Article Lancet Neurol · August 2024 Full text Link to item Cite

Comparative effectiveness of azathioprine and mycophenolate mofetil for myasthenia gravis (PROMISE-MG): a prospective cohort study.

Journal Article Lancet Neurol · March 2024 BACKGROUND: Myasthenia gravis is an autoimmune disorder of the neuromuscular junction. Treatment typically includes symptomatic oral cholinesterase inhibitors, immunosuppression, and immunomodulation. In addition to corticosteroids, azathioprine and mycoph ... Full text Link to item Cite

Pregnancy in Seronegative Myasthenia Gravis: A Single-Center Case Series.

Journal Article J Clin Neuromuscul Dis · December 1, 2023 INTRODUCTION: The course of double-seronegative myasthenia gravis (DSNMG) during and after pregnancy has not been well described. OBJECTIVE: To assess the course of DSNMG during pregnancy and within 6 months postpartum. METHODS: A retrospective cohort stud ... Full text Link to item Cite

Pregnancy in MuSK-positive myasthenia gravis: A single-center case series.

Conference Muscle Nerve · July 2023 INTRODUCTION/AIMS: Myasthenia gravis (MG) with muscle-specific tyrosine kinase (MuSK) antibodies (MMG) is predominantly seen in women of childbearing age. Our objective in this study was to describe the course of MMG during pregnancy and within 6 months po ... Full text Link to item Cite

The Duke Myasthenia Gravis Clinic Registry: II. Analysis of outcomes.

Conference Muscle Nerve · April 2023 INTRODUCTION/AIMS: The Duke Myasthenia Gravis (MG) Clinic Registry contains comprehensive physician-derived data on patients with MG seen in the Duke MG Clinic since 1980. The aim of this study was to report outcomes in patients seen in the clinic and trea ... Full text Link to item Cite

Single fiber electromyography and measuring jitter with concentric needle electrodes.

Journal Article Muscle Nerve · August 2022 This monograph contains descriptions of the single fiber electromyography (SFEMG) method and of the more recently implemented method of recording jitter with concentric needle electrodes (CNEs). SFEMG records action potentials from single muscle fibers (SF ... Full text Link to item Cite

Neurophysiological challenges in myasthenia gravis associated with MuSK antibodies: a case report.

Journal Article Neurol Sci · July 2022 Full text Link to item Cite

Single fiber EMG and measuring jitter with concentric needle electrodes.

Journal Article Muscle Nerve · June 2, 2022 This monograph contains descriptions of the single-fiber electromyography (SFEMG) method and of the more recently implemented method of recording jitter with concentric needle electrodes (CNE). SFEMG records action potentials from single muscle fibers (SFA ... Full text Link to item Cite

Advancing research in autoimmune neuromuscular disorders.

Journal Article Lancet Neurol · February 2022 Full text Link to item Cite

Identifying a patient-centered outcome measure for a comparative effectiveness treatment trial in myasthenia gravis.

Journal Article Muscle Nerve · January 2022 INTRODUCTION/AIMS: Data regarding the comparative effectiveness of myasthenia gravis (MG) treatments is not available. We used patient input to identify a patient-centered outcome measure (PCOM) for PROMISE-MG, a comparative effectiveness trial of MG treat ... Full text Link to item Cite

THE DUKE MYASTHENIA GRAVIS CLINIC REGISTRY: SINGLE FIBER EMG FINDINGS

Conference MUSCLE & NERVE · 2022 Cite

THE DUKE MYASTHENIA GRAVIS CLINIC REGISTRY: THYMECTOMY IN MUSK MYASTHENIA

Conference MUSCLE & NERVE · 2022 Cite

Rethinking the utility of acetylcholine receptor antibody titer as a pharmacodynamic biomarker for myasthenia gravis.

Journal Article Muscle Nerve · October 2021 Full text Link to item Cite

If Thymectomy Reduces the Risk of Progression of Ocular to Generalized Myasthenia Gravis, Who Should Receive it?

Journal Article Neurotherapeutics · October 2021 In this issue of Neurotherapeutics, Li et.al. report a large retrospective study of the beneficial effects of thymectomy on the progression of ocular myasthenia gravis (OMG) to generalized MG (GMG) (Huanhuan et al. in Neurotherapeutics XX, 2021). This pape ... Full text Link to item Cite

Knowledge and perceptions of the COVID-19 pandemic among patients with myasthenia gravis.

Journal Article Muscle Nerve · March 2021 BACKGROUND: Patients with myasthenia gravis (MG) may be particularly vulnerable during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic due to risk of worsening disease during infection, potential adverse impacts of coronavirus dis ... Full text Link to item Cite

The Duke myasthenia gravis clinic registry: I. Description and demographics.

Journal Article Muscle Nerve · February 2021 INTRODUCTION: The Duke Myasthenia Gravis (MG) Clinic Registry is a disease-specific database containing physician-derived data from patients seen in the Duke MG Clinic since 1980. METHODS: Data from 1060 MG patients initially seen between 1980 and 2008 wer ... Full text Link to item Cite

International Consensus Guidance for Management of Myasthenia Gravis: 2020 Update.

Journal Article Neurology · January 19, 2021 OBJECTIVE: To update the 2016 formal consensus-based guidance for the management of myasthenia gravis (MG) based on the latest evidence in the literature. METHODS: In October 2013, the Myasthenia Gravis Foundation of America appointed a Task Force to devel ... Full text Link to item Cite

Single-institutional reference values for concentric needle jitter analysis using the extrapolated reference values procedure: Comparison to published reference values.

Journal Article Muscle Nerve · January 2021 BACKGROUND: The extrapolated reference values procedure (E-Ref) was used to compare data from a single institution with the recently published reference value (RV) for concentric electrode jitter. METHODS: Data from voluntarily activated concentric needle ... Full text Link to item Cite

Epidemiological evidence for a hereditary contribution to myasthenia gravis: a retrospective cohort study of patients from North America.

Journal Article BMJ Open · September 18, 2020 OBJECTIVES: To approximate the rate of familial myasthenia gravis and the coexistence of other autoimmune disorders in the patients and their families. DESIGN: Retrospective cohort study. SETTING: Clinics across North America. PARTICIPANTS: The study inclu ... Full text Link to item Cite

AANEM - IFCN Glossary of Terms in Neuromuscular Electrodiagnostic Medicine and Ultrasound.

Journal Article Muscle Nerve · July 2020 Modern neuromuscular electrodiagnosis (EDX) and neuromuscular ultrasound (NMUS) require a universal language for effective communication in clinical practice and research and, in particular, for teaching young colleagues. Therefore, the AANEM and the IFCN ... Full text Link to item Cite

AANEM - IFCN glossary of terms in neuromuscular electrodiagnostic medicine and ultrasound.

Journal Article Clin Neurophysiol · July 2020 Modern neuromuscular electrodiagnosis (EDX) and neuromuscular ultrasound (NMUS) require a universal language for effective communication in clinical practice and research and, in particular, for teaching young colleagues. Therefore, the AANEM and the IFCN ... Full text Link to item Cite

Standards for quantification of EMG and neurography.

Journal Article Clin Neurophysiol · September 2019 This document is an update and extension of ICCN Standards published in 1999. It is the consensus of experts on the current status of EMG and Neurography methods. A panel of authors from different countries with different approach to routines in neurophysi ... Full text Link to item Cite

Validation of the triple timed up-and-go test in Lambert-Eaton myasthenia.

Journal Article Muscle Nerve · September 2019 INTRODUCTION: There are no validated, practical, and quantitative measures of disease severity in Lambert-Eaton myasthenia (LEM). METHODS: Data from the Effectiveness of 3,4-Diaminopyridine in Lambert-Eaton Myasthenic Syndrome (DAPPER) trial were analyzed ... Full text Link to item Cite

Guidelines for single fiber EMG.

Journal Article Clin Neurophysiol · August 2019 This document is the consensus of international experts on the current status of Single Fiber EMG (SFEMG) and the measurement of neuromuscular jitter with concentric needle electrodes (CNE - CN-jitter). The panel of authors was chosen based on their partic ... Full text Link to item Cite

Neuromuscular transmission in myopathies.

Journal Article Muscle Nerve · July 2019 Full text Link to item Cite

Reply.

Journal Article Muscle Nerve · October 2018 Full text Link to item Cite

Reply.

Journal Article Muscle Nerve · May 2018 Full text Link to item Cite

Randomized study of adjunctive belimumab in participants with generalized myasthenia gravis.

Journal Article Neurology · April 17, 2018 OBJECTIVE: To investigate the efficacy and safety of belimumab, a fully human immunoglobulin G1λ monoclonal antibody against B-lymphocyte stimulator, in participants with generalized myasthenia gravis (MG) who remained symptomatic despite standard of care ... Full text Link to item Cite

3,4-diaminopyridine base effectively treats the weakness of Lambert-Eaton myasthenia.

Journal Article Muscle Nerve · April 2018 INTRODUCTION: 3,4-diaminopyridine has been used to treat Lambert-Eaton myasthenia (LEM) for 30 years despite the lack of conclusive evidence of efficacy. METHODS: We conducted a randomized double-blind placebo-controlled withdrawal study in patients with L ... Full text Link to item Cite

Comparative effectiveness clinical trials to advance treatment of myasthenia gravis.

Journal Article Ann N Y Acad Sci · February 2018 Myasthenia gravis (MG) presents many challenges for establishing treatment efficacy through clinical trials. Among these are the rarity and heterogeneity of the disease, spontaneous fluctuations, prolonged latency to effect for many immunosuppressive drugs ... Full text Link to item Cite

The extrapolated reference values procedure: Theory, algorithm, and results in patients and control subjects.

Journal Article Muscle Nerve · January 2018 INTRODUCTION: Reference values (RVs) are required to separate normal from abnormal values obtained in electrodiagnostic (EDx) testing. However, it is frequently impractical to perform studies on control subjects to obtain RVs. The Extrapolated Reference Va ... Full text Link to item Cite

Reliability of the triple-timed up-and-go test.

Journal Article Muscle Nerve · January 2018 INTRODUCTION: We report the reliability of a new measure, the triple-timed up-and-go (3TUG) test, for assessing clinical function in patients with Lambert-Eaton myasthenia (LEM). METHODS: Intrarater reproducibility and interrater agreement of the 3TUG test ... Full text Link to item Cite

Developing treatment guidelines for myasthenia gravis.

Journal Article Ann N Y Acad Sci · January 2018 A task force of the Myasthenia Gravis Foundation of America recently published a formal consensus statement intended to be a treatment guide for clinicians caring for myasthenia gravis (MG) patients worldwide. Its development was stimulated by the fact tha ... Full text Link to item Cite

Problems in Comparing Jitter Values Obtained with Voluntary Activation and Electrical Stimulation.

Journal Article J Neuromuscul Dis · 2018 Comparing results from jitter studies performed with voluntary and electrical activation is difficult to perform quantitatively, particularly in complex signals as seen in reinnervation. High jitter values in individual spikes in these multispike signals c ... Full text Link to item Cite

Pitfalls and errors in measuring jitter.

Journal Article Clin Neurophysiol · November 2017 The safety factor of neuromuscular transmission can be assessed by measuring the neuromuscular jitter, which reflects the time variability of processes in the motor end-plate. Jitter is increased in any condition with disturbed end-plate function, such as ... Full text Link to item Cite

Marked clinical and jitter improvement after eculizumab in refractory myasthenia.

Journal Article Muscle Nerve · September 2017 Full text Link to item Cite

Does change in neuromuscular jitter predict or correlate with clinical change in MG?

Journal Article Muscle Nerve · July 2017 INTRODUCTION: The objective of this study was to determine if single-fiber electromyography (SFEMG) jitter accurately reflects change in severity in myasthenia gravis (MG). METHODS: We reviewed jitter and outcome data from all MG patients in our clinic who ... Full text Link to item Cite

Author response: International consensus guidance for management of myasthenia gravis: Executive summary.

Journal Article Neurology · January 31, 2017 Full text Link to item Cite

Author response: International consensus guidance for management of myasthenia gravis: Executive summary

Journal Article Neurology · January 31, 2017 Full text Cite

International clinimetric evaluation of the MG-QOL15, resulting in slight revision and subsequent validation of the MG-QOL15r.

Journal Article Muscle Nerve · December 2016 INTRODUCTION: The MG-QOL15 is a validated, health-related quality of life (HRQOL) measure for myasthenia gravis (MG). Widespread use of the scale gave us the opportunity to further analyze its clinimetric properties. METHODS: We first performed Rasch analy ... Full text Link to item Cite

Factors affecting outcome in myasthenia gravis.

Journal Article Muscle Nerve · December 2016 INTRODUCTION AND METHODS: Information from myasthenia gravis (MG) patients treated and evaluated for at least 2 years between 1980 and 2014 was reviewed to assess the effect of demographics, antibody status and titer, thymus histology, and clinical severit ... Full text Link to item Cite

International consensus guidance for management of myasthenia gravis: Executive summary.

Journal Article Neurology · July 26, 2016 OBJECTIVE: To develop formal consensus-based guidance for the management of myasthenia gravis (MG). METHODS: In October 2013, the Myasthenia Gravis Foundation of America appointed a Task Force to develop treatment guidance for MG, and a panel of 15 interna ... Full text Link to item Cite

Reference values for jitter recorded by concentric needle electrodes in healthy controls: A multicenter study.

Journal Article Muscle Nerve · March 2016 INTRODUCTION: The aim of this study was to create reference values for jitter measured with concentric needle electrodes. METHODS: Operators worldwide contributed recordings from orbicularis oculi (OO), frontalis (FR), and extensor digitorum (ED) muscles i ... Full text Link to item Cite

Lambert-Eaton myasthenia?

Journal Article Muscle Nerve · March 2016 Full text Link to item Cite

Efficacy of prednisone for the treatment of ocular myasthenia (EPITOME): A randomized, controlled trial.

Journal Article Muscle Nerve · March 2016 INTRODUCTION: In this study we evaluated the safety, tolerability, and efficacy of prednisone in patients with ocular myasthenia gravis (OMG) concurrently treated with pyridostigmine. METHODS: This investigation was a randomized, double-blind, placebo-cont ... Full text Link to item Cite

Stimulated jitter in infant botulism.

Journal Article Muscle Nerve · October 2015 Full text Link to item Cite

RESULTS FROM THE DAPPER STUDY: INPATIENT DOUBLE-BLIND PLACEBO-CONTROLLED WITHDRAWAL STUDY OF 3,4-DIAMINOPYRIDINE BASE (3,4-DAP) IN SUBJECTS WITH LAMBERTEATON MYASTHENIC SYNDROME (LEMS)

Conference MUSCLE & NERVE · October 1, 2015 Link to item Cite

Results of a Double-Blind Placebo-Controlled Study of 3,4-Diaminopyridine (DAP) in Lambert-Eaton Myasthenic Syndrome (LEMS)

Conference ANNALS OF NEUROLOGY · October 1, 2015 Link to item Cite

T CELL REACTIVITY IN INCLUSION BODY MYOSITIS (IBM)

Conference MUSCLE & NERVE · September 1, 2015 Open Access Link to item Cite

Can mycophenolate mofetil be tapered safely in myasthenia gravis? A retrospective, multicenter analysis.

Journal Article Muscle Nerve · August 2015 INTRODUCTION: Mycophenolate mofetil (MMF) is frequently used to treat myasthenia gravis, but there is little information to guide clinicians on the safety of reducing the dose in well-controlled patients. METHODS: This retrospective chart review at 3 insti ... Full text Link to item Cite

Two steps forward, one step back: mycophenolate mofetil treatment for myasthenia gravis in the United States.

Journal Article Muscle Nerve · May 2015 Full text Link to item Cite

A genome-wide association study of myasthenia gravis.

Journal Article JAMA Neurol · April 2015 IMPORTANCE: Myasthenia gravis is a chronic, autoimmune, neuromuscular disease characterized by fluctuating weakness of voluntary muscle groups. Although genetic factors are known to play a role in this neuroimmunological condition, the genetic etiology und ... Full text Link to item Cite

Characterization of B cells in muscle-specific kinase antibody myasthenia gravis.

Journal Article Neurol Neuroimmunol Neuroinflamm · April 2015 OBJECTIVE: To characterize B-cell subsets in patients with muscle-specific tyrosine kinase (MuSK) myasthenia gravis (MG). METHODS: In accordance with Human Immunology Project Consortium guidelines, we performed polychromatic flow cytometry and ELISA assays ... Full text Open Access Link to item Cite

A Double-Blinded, Randomized, Placebo-Controlled Trial to Evaluate Efficacy, Safety, and Tolerability of Single Doses of Tirasemtiv in Patients with Acetylcholine Receptor-Binding Antibody-Positive Myasthenia Gravis.

Journal Article Neurotherapeutics · April 2015 Tirasemtiv is a fast skeletal troponin activator that sensitizes the sarcomere to calcium and increases muscle force following subtetanic nerve input. In an animal model of myasthenia gravis (MG), single oral doses of tirasemtiv improved muscle force and r ... Full text Link to item Cite

PARALLEL CLINICAL AND JITTER CHANGES DURING RAPID, ECULIZUMAB-INDUCED MYASTHENIC REMISSION

Conference MUSCLE & NERVE · October 1, 2014 Link to item Cite

COMPARISON OF B10 CELLS IN IMMUNOSLTPPRESSED AND IMMUNOSUPPRESSION NAIVE ACHR plus MG

Conference MUSCLE & NERVE · October 1, 2014 Link to item Cite

Myasthenia gravis and Lambert-Eaton myasthenic syndrome.

Journal Article Continuum (Minneap Minn) · October 2014 PURPOSE OF REVIEW: This article reviews the clinical presentations, diagnostic findings, and treatment options for autoimmune myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome. RECENT FINDINGS: Immunologic research is unraveling the immunopathol ... Full text Link to item Cite

THE EFFECTS OF TIRASEMTIV, A FAST SKELETAL MUSCLE TROPONIN ACTIVATOR, ON MEASURES OF RESPIRATORY FUNCTION IN NEUROMUSCULAR DISEASES

Conference MUSCLE & NERVE · September 1, 2014 Link to item Cite

Characterization of CD4 and CD8 T cell responses in MuSK myasthenia gravis.

Journal Article J Autoimmun · August 2014 Muscle specific tyrosine kinase myasthenia gravis (MuSK MG) is a form of autoimmune MG that predominantly affects women and has unique clinical features, including prominent bulbar weakness, muscle atrophy, and excellent response to therapeutic plasma exch ... Full text Open Access Link to item Cite

Patient demographics and health plan paid costs in chronic inflammatory demyelinating polyneuropathy.

Conference Muscle Nerve · July 2014 INTRODUCTION: We determined health plan paid costs and healthcare resource usage of patients with chronic inflammatory demyelinating polyneuropathy (CIDP). METHODS: CIDP patients from 9 U.S. commercial health plans with claims in 2011 were identified from ... Full text Link to item Cite

Is the decremental pattern in Lambert-Eaton syndrome different from that in myasthenia gravis?

Journal Article Clin Neurophysiol · June 2014 OBJECTIVE: We reviewed our experience to determine if the decremental pattern during low frequency repetitive nerve stimulation (LF-RNS) distinguishes between the Lambert-Eaton myasthenic syndrome (LEMS) and myasthenia gravis (MG). METHODS: LF-RNS studies ... Full text Link to item Cite

Does change in acetylcholine receptor antibody level correlate with clinical change in myasthenia gravis?

Journal Article Muscle Nerve · April 2014 INTRODUCTION: The objective of this study is to determine if change in acetylcholine receptor antibody (AChR-ab) levels reflects change in clinical severity in patients with myasthenia gravis (MG). METHODS: We reviewed results from a prospective trial in M ... Full text Link to item Cite

Jože Trontelj; june 1, 1939 to december 9, 2013

Journal Article Muscle and Nerve · January 30, 2014 Full text Cite

Single-Fiber EMG

Chapter · January 1, 2014 Single-fiber electromyography (SFEMG) is a selective electromyography (EMG) recording technique that uniquely identifies action potentials (APs) from individual muscle fibers, thus allowing measurement of fiber density (FD) and neuromuscular jitter. FD qua ... Full text Cite

Lambert-Eaton Myasthenic Syndrome

Chapter · January 1, 2014 The Lambert-Eaton myasthenic syndrome (LEMS) is a rare autoimmune condition, in which weakness is caused by blocked release of the neurotransmitter acetylcholine from the motor nerve terminal. This condition was first described in patients with lung cancer ... Full text Cite

Do acetylcholine receptor and striated muscle antibodies predict the presence of thymoma in patients with myasthenia gravis?

Journal Article Muscle Nerve · January 2014 INTRODUCTION: Acetylcholine receptor (AChR) and striated muscle antibodies (StrAbs) are found frequently in myasthenia gravis (MG) patients with thymoma. In this study we aimed to determine the positive predictive value (PPV) and negative predictive value ... Full text Link to item Cite

Prolonged B-cell depletion in MuSK myasthenia gravis following rituximab treatment.

Journal Article Muscle Nerve · December 2013 Full text Open Access Link to item Cite

PROLONGED B CELL DEPLETION IN MUSK MYASTHENIA GRAVIS FOLLOWING RITUXIMAB TREATMENT

Conference MUSCLE & NERVE · October 1, 2013 Link to item Cite

Reference values in concentric needle electrode studies.

Journal Article Clin Neurophysiol · June 2013 Full text Link to item Cite

Measuring jitter with concentric needle electrodes.

Journal Article Muscle Nerve · March 2013 Full text Link to item Cite

A retrospective study of complications of therapeutic plasma exchange in myasthenia.

Journal Article Muscle Nerve · February 2013 INTRODUCTION: Venous access for therapeutic plasma exchange (TPE) in myasthenia gravis (MG) can be achieved by central venous catheters (CVC) or peripheral veins (PV), and the preferred method varies among providers. We evaluated our institutional experien ... Full text Link to item Cite

Reply: To PMID 22581550.

Journal Article Muscle Nerve · January 2013 Full text Link to item Cite

Patient registries: useful tools for clinical research in myasthenia gravis.

Journal Article Ann N Y Acad Sci · December 2012 Clinical registries may facilitate research on myasthenia gravis (MG) in several ways: as a source of demographic, clinical, biological, and immunological data on large numbers of patients with this rare disease; as a source of referrals for clinical trial ... Full text Link to item Cite

Design of the efficacy of prednisone in the treatment of ocular myasthenia (EPITOME) trial.

Journal Article Ann N Y Acad Sci · December 2012 Efficacy of Prednisone in the Treatment of Ocular Myasthenia (EPITOME) is a multicenter, randomized, double blind, placebo-controlled trial that is being conducted under the auspices of the Muscle Study Group. EPITOME is the first randomized control trial ... Full text Link to item Cite

DOES THE PRESENCE OR LEVEL OF ACETYLCHOLINE RECEPTOR ANTIBODY (ACHR-AB) PREDICT GENERALIZATION IN OCULAR MYASTHENIA (OM)?

Conference MUSCLE & NERVE · October 1, 2012 Link to item Cite

DOES THE ACETYLCHOLINE RECEPTOR ANTIBODY LEVEL PREDICT OR CORRELATE WITH THE OUTCOME IN MG?

Conference MUSCLE & NERVE · October 1, 2012 Link to item Cite

DOES CHANGE IN ACETYLCHOLINE RECEPTOR ANTIBODY (ACHR-AB) LEVEL PREDICT OR CORRELATE WITH CLINICAL CHANGE IN MG?

Conference MUSCLE & NERVE · October 1, 2012 Link to item Cite

Muscle autoantibodies in myasthenia gravis: beyond diagnosis?

Journal Article Expert Rev Clin Immunol · July 2012 Myasthenia gravis is an autoimmune disorder of the neuromuscular junction. A number of molecules, including ion channels and other proteins at the neuromuscular junction, may be targeted by autoantibodies leading to abnormal neuromuscular transmission. In ... Full text Link to item Cite

Recommendations for myasthenia gravis clinical trials.

Journal Article Muscle Nerve · June 2012 The recommendations for clinical research standards published in 2000 by a task force of the Medical Scientific Advisory Board (MSAB) of the Myasthenia Gravis Foundation of America (MGFA) were largely successful in introducing greater uniformity in the rec ... Full text Link to item Cite

Psychometric evaluation of the myasthenia gravis composite using Rasch analysis.

Journal Article Muscle Nerve · June 2012 INTRODUCTION: The MG Composite (MGC) is a validated outcome measure of the clinical manifestations of myasthenia gravis. METHODS: We performed Rasch analyses of the MGC to investigate additional properties, including its unidimensionality and the appropria ... Full text Link to item Cite

Electrophysiologic Study of Disorders of Neuromuscular Transmission

Journal Article · March 29, 2012 Full text Cite

Estimated cost of treating myasthenia gravis in an insured U.S. population.

Journal Article Muscle Nerve · March 2012 INTRODUCTION: In this study we estimated the costs paid by U.S. health plans for treating myasthenia gravis (MG) in 2009 and determined the major cost drivers. METHODS: One hundred thirteen MG patients were matched by propensity scores with 339 non-MG pati ... Full text Link to item Cite

If you build a rare disease registry, will they enroll and will they use it? Methods and data from the National Registry of Myotonic Dystrophy (DM) and Facioscapulohumeral Muscular Dystrophy (FSHD).

Journal Article Contemp Clin Trials · March 2012 INTRODUCTION: Registries are becoming increasingly important for rare diseases as experimental therapies develop. This report describes the methodology behind the National Registry of Myotonic Dystrophy (DM) and Facioscapulohumeral Muscular Dystrophy (FSHD ... Full text Link to item Cite

Cost analysis of myasthenia gravis from a large U.S. insurance database.

Journal Article Muscle Nerve · December 2011 INTRODUCTION: Little is known about the costs of managing rare diseases, and comprehensive healthcare costs have not been reported for myasthenia gravis (MG). We evaluated the direct costs and healthcare resource utilization in insured MG patients. METHODS ... Full text Link to item Cite

PLASMA EXCHANGE COMPLICATIONS ARE RELATED TO THE VENOUS ACCESS ROUTE

Conference MUSCLE & NERVE · October 1, 2011 Link to item Cite

INCREASED OCCURRENCE OF LATE ONSET MYASTHENIA GRAVIS

Conference MUSCLE & NERVE · October 1, 2011 Link to item Cite

DO ANTIBODIES PREDICT THE PRESENCE OR ABSENCE OF THYMOMA IN MYASTHENIA GRAVIS?

Conference MUSCLE & NERVE · October 1, 2011 Link to item Cite

Approach to Diseases of the Neuromuscular Junction

Journal Article · September 6, 2011 Diseases of the neuromuscular junction are rare, and few physicians have seen enough patients with them to easily recognize all the ways in which they can present. Yet, the most important step in making the diagnosis is to think of these conditions. This c ... Full text Cite

The importance of studying history: lessons learnt from a trial of tacrolimus in myasthenia gravis.

Journal Article J Neurol Neurosurg Psychiatry · September 2011 Full text Link to item Cite

Anti-MuSK antibody myasthenia gravis: clinical findings and response to treatment in two large cohorts.

Journal Article Muscle Nerve · July 2011 INTRODUCTION: Myasthenia gravis (MG) patients with autoantibodies to muscle-specific tyrosine kinase (MuSK) represent a distinct subset of those with this disease. Treatment and outcomes data in these patients are limited and conflicting. METHODS: We revie ... Full text Link to item Cite

Prognostic Value of Clinical Response to Acetylcholinesterase Inhibitors in Myasthenia Gravis with Anti-MuSK Antibodies

Conference NEUROLOGY · March 1, 2011 Link to item Cite

Approach to Diseases of the Neuromuscular Junction

Chapter · 2011 Cite

The MG-QOL15 for following the health-related quality of life of patients with myasthenia gravis.

Journal Article Muscle Nerve · January 2011 Featured Publication The MG-QOL15 is helpful in informing the clinician about the patient's perception of the extent of and dissatisfaction with myasthenia gravis (MG)-related dysfunction. The aims of this study were to determine the usefulness of the MG-QOL15 for following in ... Full text Link to item Cite

Update on muscle-specific tyrosine kinase antibody positive myasthenia gravis.

Journal Article Curr Opin Neurol · October 2010 PURPOSE OF REVIEW: Important concepts regarding the pathogenesis, clinical features, diagnosis and treatment of muscle-specific tyrosine kinase (MuSK) antibody positive myasthenia gravis will be reviewed. Special attention will be paid to clinical phenotyp ... Full text Link to item Cite

Immunosuppressive therapies in myasthenia gravis.

Journal Article Autoimmunity · August 2010 Featured Publication Immunosuppression is the mainstay of treatment for myasthenia gravis (MG). In this paper, we review the mechanisms of action and clinical application of corticosteroids and different classes of immunosuppressive drugs that are currently used in MG patients ... Full text Link to item Cite

The MG Composite: A valid and reliable outcome measure for myasthenia gravis.

Journal Article Neurology · May 4, 2010 Featured Publication OBJECTIVE: To study the concurrent and construct validity and test-retest reliability in the practice setting of an outcome measure for myasthenia gravis (MG). METHODS: Eleven centers participated in the validation study of the Myasthenia Gravis Composite ... Full text Link to item Cite

Mycophenolate mofetil in AChR-antibody-positive myasthenia gravis: outcomes in 102 patients.

Journal Article Muscle Nerve · May 2010 Featured Publication Two recent randomized, controlled trials failed to demonstrate a benefit of mycophenolate mofetil (MMF) over prednisone in the treatment of myasthenia gravis (MG). We reviewed our experience with MMF in MG to determine whether these trials may have been un ... Full text Link to item Cite

Construct and concurrent validation of the MG-QOL15 in the practice setting.

Journal Article Muscle Nerve · February 2010 Health-related quality of life (HRQOL) estimates can play an important role in patient care by providing information about the patient's perception of impairment and disability and the degree to which the patient tolerates disease manifestations. The 15-it ... Full text Link to item Cite

Change in urethral sphincter neuromuscular function during pregnancy persists after delivery.

Journal Article Am J Obstet Gynecol · November 2009 OBJECTIVE: The purpose of this study was to assess the effect of pregnancy and first vaginal delivery on urethral striated sphincter neuromuscular function. STUDY DESIGN: Quantitative electromyographic (EMG) interference pattern analysis of the urethral sp ... Full text Link to item Cite

IN65-FR-02 Rationale for thymectomy in myasthenia gravis

Conference Journal of the Neurological Sciences · October 2009 Full text Cite

Jitter recordings with concentric needle electrodes.

Journal Article Muscle Nerve · September 2009 Featured Publication Neuromuscular jitter is generally recorded with a single fiber (SF) electromyography (EMG) electrode. Due to concern about using reusable needle electrodes, an acceptable alternative for the SF electrode has been sought. This is a review of the issues invo ... Full text Link to item Cite

Levator ani denervation and reinnervation 6 months after childbirth.

Journal Article Am J Obstet Gynecol · May 2009 OBJECTIVE: The objective of the study was to assess the prevalence of levator ani denervation and reinnervation 6 months after the first delivery. STUDY DESIGN: Ninety-six primigravida women underwent quantitative electromyography of the levator ani during ... Full text Link to item Cite

Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity.

Journal Article Lancet Neurol · May 2009 Featured Publication Acquired myasthenia gravis (MG) is an autoimmune disorder of the neuromuscular junction in which patients experience fluctuating skeletal muscle weakness that often affects selected muscle groups preferentially. The target of the autoimmune attack in most ... Full text Link to item Cite

Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion.

Journal Article Brain Res Bull · December 16, 2008 Although developmental exposures of rats to low levels of the organophosphate pesticides (OPs), chlorpyrifos (CPF) or diazinon (DZN), both cause persistent neurobehavioral effects, there are important differences in their neurotoxicity. The current study e ... Full text Link to item Cite

Construction of an efficient evaluative instrument for myasthenia gravis: the MG composite.

Journal Article Muscle Nerve · December 2008 We assessed the performance of items from the Quantitative Myasthenia Gravis (QMG), MMT (Manual Muscle Test), and MG-ADL (Myasthenia Gravis - Activities of Daily Living) scales, using data from two recently completed treatment trials of generalized MG. Ite ... Full text Link to item Cite

Reply to "Diagnostic value of wrist median nerve cross sectional area versus wrist-to-forearm ratio in carpal tunnel syndrome"

Journal Article Clinical Neurophysiology · December 1, 2008 Full text Cite

Comparison of outcome measures from a trial of mycophenolate mofetil in myasthenia gravis.

Journal Article Muscle Nerve · November 2008 We determined the strength of correlation among, and responsiveness of, outcome measures used in a multicenter, double-blind, placebo-controlled trial of mycophenolate mofetil in combination with prednisone in myasthenia gravis (MG). The primary efficacy m ... Full text Link to item Cite

Mycophenolate mofetil in myasthenia gravis: the unanswered question.

Journal Article Expert Opin Pharmacother · October 2008 Myasthenia gravis (MG) is an autoimmune disease that leads to muscular weakness, which can significantly affect the patient's daily functions. If left untreated, the mortality rate can be as high as 30%. Effective immunosuppression is the cornerstone of tr ... Full text Link to item Cite

MuSK-antibody positive myasthenia gravis: questions from the clinic.

Journal Article J Neuroimmunol · September 15, 2008 Clinical vignettes are presented of five patients with MuSK-antibody positive myasthenia gravis, each of which demonstrates a diagnostic or therapeutic issue that is unique to or characteristic of this condition. Consideration of these issues leads to ques ... Full text Link to item Cite

An international, phase III, randomized trial of mycophenolate mofetil in myasthenia gravis.

Journal Article Neurology · August 5, 2008 Featured Publication BACKGROUND: This prospective, randomized, double-blind, placebo-controlled, phase III trial assessed the efficacy, safety, and tolerability of mycophenolate mofetil (MMF) as a steroid-sparing agent in patients with myasthenia gravis (MG). METHODS: Patients ... Full text Link to item Cite

A trial of mycophenolate mofetil with prednisone as initial immunotherapy in myasthenia gravis.

Journal Article Neurology · August 5, 2008 OBJECTIVE: To test the hypothesis that mycophenolate mofetil (MMF) with prednisone provides better control of myasthenic weakness than prednisone alone in the initial management of generalized myasthenia gravis (MG). METHODS: Eighty immunosuppression naïve ... Full text Link to item Cite

Disease-specific measure of quality of life for myasthenia gravis.

Journal Article Muscle Nerve · August 2008 In 2000 a Task Force of the Myasthenia Gravis Foundation of America recommended development of a quality of life (QOL) measure specific for myasthenia gravis (MG). Extant investigations have relied solely on assessment of physical aspects of daily living i ... Full text Link to item Cite

Less is more, or almost as much: a 15-item quality-of-life instrument for myasthenia gravis.

Journal Article Muscle Nerve · August 2008 We describe the process whereby a recently developed myasthenia gravis (MG)-specific quality-of-life (QOL) instrument was reduced from 60 items to 15 items while maintaining potential usefulness in the clinic and in prospective treatment trials. In data fr ... Full text Link to item Cite

The ultrasonographic wrist-to-forearm median nerve area ratio in carpal tunnel syndrome.

Journal Article Clin Neurophysiol · June 2008 OBJECTIVE: Peripheral nerve ultrasound is an emerging tool in the diagnosis of carpal tunnel syndrome (CTS). Although numerous publications have cited an increased median nerve area at the wrist to be the diagnostic of CTS, there has been considerable vari ... Full text Link to item Cite

Lessons from two trials of mycophenolate mofetil in myasthenia gravis.

Journal Article Ann N Y Acad Sci · 2008 Featured Publication Two randomized controlled trials of mycophenolate mofetil (MMF) in the treatment of myasthenia gravis (MG) were recently completed. Although neither study demonstrated efficacy of MMF in the population of patients studied, there are valuable lessons in the ... Full text Link to item Cite

The Lambert-Eaton myasthenic syndrome.

Journal Article Handb Clin Neurol · 2008 Featured Publication Full text Link to item Cite

Clinical features of myasthenia gravis.

Journal Article Handb Clin Neurol · 2008 Featured Publication Full text Link to item Cite

Chapter 12 Neurotoxicology of neuromuscular transmission.

Journal Article Handb Clin Neurol · 2008 Full text Link to item Cite

Neuromuscular Transmission Defects

Journal Article · December 1, 2006 Full text Cite

Muscle-specific kinase antibody myasthenia gravis: Response to treatment in 25 patients

Conference MUSCLE & NERVE · October 1, 2006 Link to item Cite

Lambert-Eaton myasthenic syndrome: Findings in 97 patients

Conference MUSCLE & NERVE · October 1, 2006 Link to item Cite

Peripheral neuropathy in Krabbe disease: electrodiagnostic findings.

Journal Article Neurology · July 25, 2006 BACKGROUND: Krabbe disease (KD) is associated with marked central and peripheral demyelination and nerve conduction studies (NCS) typically show a mixed sensorimotor demyelinating peripheral neuropathy (PN). OBJECTIVES: To further characterize the PN in a ... Full text Link to item Cite

Peripheral neuropathy in Krabbe disease: effect of hematopoietic stem cell transplantation.

Journal Article Neurology · July 25, 2006 BACKGROUND: Hematopoietic stem cell transplantation (HSCT) may slow the progression of Krabbe disease (KD) if performed early in the disease. The authors' studies indicate that more than 90% of patients with KD have severe abnormalities in peripheral nerve ... Full text Link to item Cite

Long-term results of tacrolimus in cyclosporine- and prednisone-dependent myasthenia gravis.

Journal Article Neurology · March 28, 2006 Full text Link to item Cite

Electrophysiologic Study of Disorders of Neuromuscular Transmission

Journal Article · December 1, 2005 Full text Cite

MuSK-antibody positive myasthenia gravis: clinical and electrodiagnostic patterns.

Journal Article Clin Neurophysiol · September 2005 Featured Publication OBJECTIVE: To examine the clinical manifestations and patterns of electromyographic abnormalities in MuSK-Ab positive myasthenia gravis. METHODS: The clinical evaluations and electrodiagnostic testing results of 20 MuSK-Ab positive myasthenia gravis patien ... Full text Link to item Cite

Advances in the diagnosis of neuromuscular junction disorders.

Journal Article Am J Phys Med Rehabil · August 2005 Featured Publication Disorders of the neuromuscular junction have a wide range of clinical presentations, which frequently poses a diagnostic challenge to evaluating clinicians. This article describes the tests used in the diagnosis of diseases of the neuromuscular junction, r ... Full text Link to item Cite

Quantitative myasthenia gravis score: assessment of responsiveness and longitudinal validity.

Journal Article Neurology · June 14, 2005 We prospectively tested the quantitative myasthenia gravis score (QMG) for responsiveness and longitudinal construct validity in 53 patients with myasthenia gravis. Index of responsiveness was high. Longitudinal construct validity was confirmed by the corr ... Full text Link to item Cite

Electrophysiologic Study of Disorders of Neuromuscular Transmission

Chapter · April 20, 2005 Full text Cite

Myasthenia gravis: diagnosis.

Journal Article Semin Neurol · March 2004 The clinical history and neurological examination provide the most important data on which the diagnosis of autoimmune myasthenia gravis (MG) is based. MG produces symptomatic weakness that predominates in certain muscle groups and typically fluctuates in ... Full text Link to item Cite

Electrophysiologic tests of neuromuscular transmission.

Journal Article Suppl Clin Neurophysiol · 2004 Featured Publication Full text Link to item Cite

Chapter 25 Neuromuscular junction disorders

Journal Article Handbook of Clinical Neurophysiology · December 1, 2003 Full text Cite

Chapter 14 Repetitive nerve stimulation

Journal Article Handbook of Clinical Neurophysiology · December 1, 2003 Full text Cite

Mycophenolate mofetil for myasthenia gravis: an analysis of efficacy, safety, and tolerability.

Journal Article Neurology · November 25, 2003 The authors report a retrospective analysis of the use of mycophenolate mofetil (MyM) in 85 patients with autoimmune myasthenia gravis. The Myasthenia Gravis Foundation of America (MGFA) postintervention status (PIS) was used to characterize the treatment ... Full text Link to item Cite

Lambert-eaton myasthenic syndrome: diagnosis and treatment.

Journal Article Ann N Y Acad Sci · September 2003 A high index of suspicion is essential in arriving at the correct diagnosis of Lambert-Eaton myasthenic syndrome (LEMS). LEMS should be considered in the differential in any patient who has proximal weakness, reduced or absent muscle stretch reflexes, and ... Full text Link to item Cite

A simple manual muscle test for myasthenia gravis: validation and comparison with the QMG score.

Journal Article Ann N Y Acad Sci · September 2003 Featured Publication Full text Link to item Cite

Antibodies in sera of patients with late-onset myasthenia gravis recognize the PEVK domain of titin.

Journal Article Ann N Y Acad Sci · September 2003 Full text Link to item Cite

Thymectomy for myasthenia gravis: evaluation requires controlled prospective studies.

Journal Article Ann Thorac Surg · July 2003 Full text Link to item Cite

Clinical aspects of MuSK antibody positive seronegative MG.

Journal Article Neurology · June 24, 2003 Serum antibodies to muscle-specific receptor tyrosine kinase were detected in 12 of 32 patients with generalized seronegative MG. All were women, with onset between ages 21 and 59 years. Seven had prominent neck, shoulder, or respiratory muscle weakness an ... Full text Link to item Cite

Preoperative preparation of patients with myasthenia gravis forestalls postoperative respiratory complications after thymectomy.

Journal Article Ann Thorac Surg · March 2003 Full text Link to item Cite

Lambert–Eaton Myasthenic Syndrome

Chapter · January 1, 2003 Full text Cite

Single-Fiber EMG

Chapter · January 1, 2003 Full text Cite

Treatment of myasthenia gravis: current practice and future directions.

Journal Article Expert Rev Neurother · September 2002 Myasthenia gravis is the best understood of the autoimmune diseases and a number of treatments are currently used to produce clinical improvement. However, due to the scarcity of evidence-based and comparative data, there is still no consensus on many ther ... Full text Link to item Cite

On the concept of myasthenic crisis.

Journal Article J Clin Neuromuscul Dis · September 2002 This article reviews controversies surrounding the concept of myasthenic crisis. Literature review and our own experience demonstrate that there is disagreement about how a crisis should be defined, what the implications of a crisis are, whether crises are ... Full text Link to item Cite

Problems in the evaluation of thymectomy for myasthenia gravis.

Journal Article Ann Thorac Surg · March 2002 Full text Link to item Cite

Steroid treatment for myasthenia gravis: steroids have an important role.

Journal Article Muscle Nerve · January 2002 Full text Link to item Cite

The Lambert-Eaton myasthenic syndrome.

Journal Article Adv Neurol · 2002 Link to item Cite

Advances in myasthenia gravis.

Journal Article Curr Neurol Neurosci Rep · January 2002 Recent advances in the diagnosis and treatment of acquired myasthenia gravis (MG) are reviewed. Increased awareness about the need for more uniform methods of reporting treatment trials for MG has prompted systematic review of the literature and inspired a ... Full text Link to item Cite

Clinical impact of single-fiber electromyography.

Journal Article Muscle Nerve Suppl · 2002 Featured Publication The major clinical impact of single-fiber electromyography has been from its role in confirming, or excluding, the diagnosis of myasthenia gravis (MG). Jitter measurements also have a clinical role in demonstrating changes in disease severity in patients w ... Full text Link to item Cite

Isaacs' syndrome as a potassium channelopathy of the nerve.

Journal Article Muscle Nerve Suppl · 2002 Isaacs' syndrome (acquired neuromyotonia) is an antibody-mediated potassium channel disorder (channelopathy). The target channel proteins of the antigens are voltage-gated potassium channels (VGKCs), especially dendrotoxin-sensitive fast potassium channels ... Full text Link to item Cite

Clinical impact of single-fiber electromyography.

Journal Article Muscle Nerve Suppl · 2002 The major clinical impact of single-fiber electromyography has been from its role in confirming, or excluding, the diagnosis of myasthenia gravis (MG). Jitter measurements also have a clinical role in demonstrating changes in disease severity in patients w ... Link to item Cite

Thymectomy for myasthenia gravis in older patients.

Journal Article J Am Coll Surg · September 2001 Full text Link to item Cite

Effect of thymectomy on human peripheral blood T cell pools in myasthenia gravis.

Journal Article J Immunol · February 15, 2001 The human thymus is required for establishment of the T cell pool in fetal life, but postnatal thymectomy does not lead to immunodeficiency in humans. Because thymectomy in humans is performed for treatment of myasthenia gravis (MG), we have studied patien ... Full text Link to item Cite

Mycophenolate mofetil for myasthenia gravis: an open-label pilot study.

Journal Article Neurology · January 9, 2001 In an open-label study, 12 patients with refractory MG or who were taking only corticosteroids and required additional immunosuppression received mycophenolate mofetil 1 g twice daily for 6 months. A reduction of three points in a quantified MG score and t ... Full text Link to item Cite

Pelvic muscle electromyography of levator ani and external anal sphincter in nulliparous women and women with pelvic floor dysfunction.

Journal Article Am J Obstet Gynecol · December 2000 OBJECTIVE: The purpose of this study was to compare results of electromyographic assessment of muscular recruitment between nulliparous control subjects without pelvic floor dysfunction and parous subjects with genuine stress urinary incontinence and with ... Full text Link to item Cite

Quantitative electromyographic analysis of levator ani and external anal sphincter muscles of nulliparous women.

Journal Article Am J Obstet Gynecol · November 2000 OBJECTIVES: Our aims were to introduce a method of digital quantitative electromyography of the levator ani and external anal sphincter muscles and to establish reference values. STUDY DESIGN: Fifteen nulliparous, symptom-free women underwent concentric ne ... Full text Link to item Cite

Predictive value of single-fiber electromyography in the extensor digitorum communis muscle of patients with ocular myasthenia gravis: a retrospective study.

Journal Article J Clin Neuromuscul Dis · September 2000 PURPOSE: To determine if the jitter in the extensor digitorum communis (EDC) muscle in patients with purely ocular myasthenia gravis (OMG) predicts the subsequent development of generalized myasthenic weakness-Methods: Included in this retrospective study ... Full text Link to item Cite

Retrospective analysis of the use of cyclosporine in myasthenia gravis.

Journal Article Neurology · August 8, 2000 The authors reviewed the records of patients with myasthenia gravis who took cyclosporine for at least 6 months between November 1987 and January 1999. Of 57 patients who took cyclosporine for an average of 3.5 years, 55 (96%) had clinical improvement. The ... Full text Link to item Cite

Myasthenia gravis: recommendations for clinical research standards. Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America.

Journal Article Neurology · July 12, 2000 Full text Link to item Cite

Myasthenia gravis: recommendations for clinical research standards. Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America.

Journal Article Ann Thorac Surg · July 2000 Full text Link to item Cite

Lambert-Eaton myasthenic syndrome: electrodiagnostic findings and response to treatment.

Journal Article Neurology · June 13, 2000 Featured Publication The authors reviewed the incidence of cancer, repetitive nerve stimulation findings, and response to treatment in 73 patients with Lambert-Eaton myasthenic syndrome. Thirty-one patients (42%) had lung cancer, 29 small cell. Doubling of the compound motor a ... Full text Link to item Cite

Hidden afterdischarges in slow channel congenital myasthenic syndrome.

Journal Article J Clin Neuromuscul Dis · June 2000 Afterdischarges in motor nerve stimulation studies help distinguish slow channel congenital myasthenic syndrome (SCCMS) from acquired myasthenia gravis (MG) We present a patient with fatigable weakness in whom afterdischarges were not initially apparent. A ... Full text Link to item Cite

Some observations on fibrillations and positive sharp waves.

Journal Article Muscle Nerve · June 2000 Electromyographic recordings of fibrillation potentials (FPs) and positive sharp waves (PSWs) demonstrate transformation of FP to PSW and vice versa, atypical firing patterns, changes in waveform shape and amplitude, and time-locked potentials. The etiolog ... Full text Link to item Cite

How to handle myasthenic crisis. Essential steps in patient care.

Journal Article Postgrad Med · April 2000 Myasthenic crisis, or respiratory failure requiring intubation and mechanical ventilation, may be caused by infections, aspiration, physical and emotional stress, and changes in medication. Although no single factor determines the need for respiratory supp ... Full text Link to item Cite

A randomized trial of 3,4-diaminopyridine in Lambert-Eaton myasthenic syndrome.

Journal Article Neurology · February 8, 2000 Featured Publication OBJECTIVES: The authors report the results of a prospective, placebo-controlled, randomized study to evaluate the effectiveness of 3,4-diaminopyridine (DAP) in patients with Lambert-Eaton myasthenic syndrome (LEMS) and to determine the acute and long-term ... Full text Link to item Cite

The clinical neurophysiology of diseases of neuromuscular transmission.

Journal Article Suppl Clin Neurophysiol · 2000 Full text Link to item Cite

Distinguishing clinical and electrodiagnostic features of X-linked bulbospinal neuronopathy.

Journal Article Muscle Nerve · December 1999 X-linked bulbospinal neuronopathy (XLBSN) or Kennedys disease is a rare inherited neuromuscular disease characterized by adult-onset muscle weakness, usually in a limb-girdle distribution. It is frequently misdiagnosed despite a distinctive clinical presen ... Full text Link to item Cite

Prominent inflammatory changes on muscle biopsy in patients with Miyoshi myopathy.

Journal Article Neuromuscul Disord · October 1999 Miyoshi myopathy is a rare autosomal recessive distal myopathy characterized by early and prominent involvement of the posterior compartment of the legs. We describe two patients with the clinical diagnosis of Miyoshi myopathy who demonstrated marked infla ... Full text Link to item Cite

Neuroendocrine lung tumors and disorders of the neuromuscular junction.

Journal Article Neurology · April 22, 1999 We report four cases of Lambert-Eaton myasthenic syndrome (LEMS) or myasthenia gravis (MG) associated with pulmonary neuroendocrine carcinoma having prolonged survival. The tumors were atypical carcinoid or large cell neuroendocrine carcinoma. LEMS is asso ... Full text Link to item Cite

Conduction block and continuous motor unit activity in chronic acquired demyelinating polyneuropathy.

Journal Article Muscle Nerve · April 1999 The term continuous motor unit activity (CMUA) may be used to refer to the involuntary, sustained activity of motor units caused by hyperactivity of peripheral motor nerves. CMUA has been reported in association with acquired neuropathies such as chronic i ... Full text Link to item Cite

Lambert-Eaton myasthenic syndrome (LEMS). Clinical and electrodiagnostic features and response to therapy in 59 patients.

Journal Article Ann N Y Acad Sci · May 13, 1998 Full text Link to item Cite

Acetylcholine receptor antibody measurements in acquired myasthenia gravis. Diagnostic sensitivity and predictive value for thymoma.

Journal Article Ann N Y Acad Sci · May 13, 1998 Full text Link to item Cite

3,4-Diaminopyridine (DAP) in the treatment of Lambert-Eaton myasthenic syndrome (LEMS).

Journal Article Ann N Y Acad Sci · May 13, 1998 Full text Link to item Cite

Thymectomy task force formed by the medical advisory board of the Myasthenia Gravis Foundation of America

Journal Article ANNALS OF THORACIC SURGERY · November 1, 1997 Link to item Cite

Surgical treatment of carpal tunnel syndrome in patients with peripheral neuropathy.

Journal Article Neurology · October 1997 Outcome after carpal tunnel surgery was studied retrospectively in 32 patients with peripheral neuropathy and carpal tunnel syndrome. Nocturnal paresthesias were almost universally relieved, followed in order of responsiveness by pain, numbness, and weakne ... Full text Link to item Cite

Seronegative myasthenia gravis

Journal Article Neurology · April 1, 1997 Cite

Surgical treatment of carpal tunnel syndrome in patients with peripheral neuropathy

Journal Article NEUROLOGY · March 1, 1997 Link to item Cite

Correlation of acetylcholine receptor antibody binding, modulating and blocking activity with jitter measurements in myasthenia gravis

Conference NEUROLOGY · 1997 Cite

Do acetylcholine receptor antibody binding, modulating and blocking activity measurements correlate with disease severity in myasthenia gravis?

Conference NEUROLOGY · 1997 Cite

Quantitative motor unit potential analysis.

Journal Article J Clin Neurophysiol · September 1996 Featured Publication A review of quantitative methods for electromyography is given. Background information about motor unit anatomy, physiology, and pathology is provided to explain some of the presented electrophysiological phenomena. Different aspects of quantitation, such ... Full text Link to item Cite

Multivariate discriminant analysis of the electromyographic interference pattern: statistical approach to discrimination among controls, myopathies and neuropathies.

Journal Article Med Biol Eng Comput · September 1996 The stepwise linear discriminant analysis method is used to develop optimal combinations of features measured from the electromyographic interference pattern, with the aim of minimising the misclassification rate in controls while maximising the correct cl ... Full text Link to item Cite

Analysis of the electromyographic interference pattern.

Journal Article J Clin Neurophysiol · September 1996 Featured Publication The electromyographic interference pattern (EMG-IP) contains information about the number, firing rate, and recruitment characteristics of motor units, and information regarding the waveforms of the recruited motor units. Muscle and nerve diseases produce ... Full text Link to item Cite

AAEM minimonograph #25: single-fiber electromyography.

Journal Article Muscle Nerve · September 1996 Featured Publication Single-fiber electromyography (SFEMG) is a selective recording technique in which a needle electrode with a small recording surface in the side is used to identify action potentials from individual muscle fibers. The SFEMG parameters of greatest clinical u ... Full text Link to item Cite

Lambert-Eaton sera reduce low-voltage and high-voltage activated Ca2+ currents in murine dorsal root ganglion neurons.

Journal Article Proc Natl Acad Sci U S A · August 20, 1996 Voltage-gated Ca2+ channels are categorized as either high-voltage activated (HVA) or low-voltage activated (LVA), and a subtype (or subtypes) of HVA Ca2+ channels link the presynaptic depolarization to rapid neuro-transmitter release. Reductions in transm ... Full text Link to item Cite

Clinical correlates in the deep tendon reflexes of the electrophysiology in the Lambert-Eaton myasthenic syndrome and myasthenia gravis.

Journal Article Muscle Nerve · August 1995 Full text Link to item Cite

Lambert-Eaton myasthenic syndrome: clinical diagnosis, immune-mediated mechanisms, and update on therapies.

Journal Article Ann Neurol · May 1995 The Lambert-Eaton myasthenic syndrome (LEMS) is a rare condition in which weakness results from a presynaptic abnormality of acetylcholine release at the neuromuscular junction. It was first described as a paraneoplastic syndrome in patients with lung canc ... Full text Link to item Cite

Repetitive nerve stimulation studies in the Lambert-Eaton myasthenic syndrome.

Journal Article Muscle Nerve · September 1994 We compared changes in amplitude and area of surface recorded compound motor action potentials (CMAPs) during 20-Hz repetitive nerve stimulation and after maximum voluntary contraction in patients with the Lambert-Eaton myasthenic syndrome (LEMS), myasthen ... Full text Link to item Cite

Race, sex, and puberty influence onset, severity, and outcome in juvenile myasthenia gravis.

Journal Article Neurology · July 1994 Featured Publication We assessed the influence of race, sex, and puberty upon clinical features and outcome in 115 patients with autoimmune juvenile myasthenia gravis (JMG). These demographic variables influenced not only disease incidence but also disease severity, response t ... Full text Link to item Cite

Lambert-Eaton myasthenic syndrome: pathogenesis and treatment.

Journal Article Semin Neurol · June 1994 Full text Link to item Cite

The electrodiagnosis of myasthenia gravis and the Lambert-Eaton myasthenic syndrome.

Journal Article Neurol Clin · May 1994 Electrodiagnostic studies are valuable in confirming the diagnosis of a disorder of neuromuscular transmission. They are used to distinguish presynaptic and postsynaptic abnormalities. These studies provide an objective measure of the severity of the illne ... Link to item Cite

The treatment of patients with myasthenia gravis.

Journal Article Neurol Clin · May 1994 Although there is general agreement among experienced physicians on the usefulness of different treatments for myasthenia gravis (MG), so many variations are possible that in practice, similar patients treated by different physicians rarely are treated the ... Link to item Cite

MYASTHENIA-GRAVIS AND MYASTHENIC SYNDROMES - PREFACE

Journal Article NEUROLOGIC CLINICS · May 1, 1994 Link to item Cite

Single fiber EMG and repetitive stimulation of the same muscle in myasthenia gravis.

Journal Article Muscle Nerve · February 1994 We performed RNS and SFEMG studies of the same muscle in 46 patients with myasthenia gravis. Maximum decrement to 3-5-Hz stimulation before and after maximum voluntary exercise, percentage of action potential pairs with increased jitter and blocking, and m ... Full text Link to item Cite

Bell's palsy: an eponym that often leads to confusion.

Journal Article Muscle Nerve · January 1994 Link to item Cite

Preface

Journal Article Neurologic Clinics · January 1, 1994 Full text Cite

3,4-Diaminopyridine in Lambert-Eaton myasthenic syndrome and myasthenia gravis.

Journal Article Ann N Y Acad Sci · June 21, 1993 Full text Link to item Cite

Single-fiber EMG and repetitive stimulation of the same muscle in myasthenia gravis.

Journal Article Ann N Y Acad Sci · June 21, 1993 Full text Link to item Cite

Acetylcholine receptor antibodies in juvenile myasthenia gravis.

Journal Article Neurology · May 1993 We analyzed relationships among pubertal stage at disease onset, sex, disease severity, and acetylcholine receptor antibody (AChR Ab) levels in 46 patients with autoimmune juvenile myasthenia gravis (JMG). Female predominance was least in children with pre ... Full text Link to item Cite

Single fiber electromyography in myasthenia gravis during pregnancy.

Journal Article Muscle Nerve · May 1993 We report the use of single fiber electromyography (SFEMG) to demonstrate changes in the physiologic abnormality of myasthenia gravis (MG) during pregnancy. A 23-year-old became pregnant 15 months after the onset of mild ocular weakness. On initial evaluat ... Full text Link to item Cite

Clinical neurophysiology of disorders of the neuromuscular junction.

Journal Article J Clin Neurophysiol · April 1993 This is a review of the neurophysiological techniques used clinically to demonstrate abnormalities of neuromuscular transmission. The use of these tests in myasthenia gravis, Lambert-Eaton myasthenic syndrome, congenital myasthenic syndromes, and other con ... Full text Link to item Cite

MUAP analysis using Bayes classifier.

Journal Article Muscle Nerve · August 1992 Link to item Cite

Postpericardiotomy syndrome following thymectomy.

Journal Article Clin Pediatr (Phila) · May 1992 Full text Link to item Cite

The effect of firing rate on neuromuscular jitter in Lambert-Eaton myasthenic syndrome.

Journal Article Muscle Nerve · February 1992 Link to item Cite

Letters to the editor

Journal Article Muscle & Nerve · January 1, 1992 Full text Cite

Letters to the editor

Journal Article Muscle & Nerve · January 1, 1992 Full text Cite

Single fiber EMG reference values: A collaborative effort

Journal Article Muscle and Nerve · 1992 Single fiber electromyography (SFEMG) measurements of fiber density and jitter are used in the diagnosis of a variety of peripheral nervous system disorders. However, the normal values of these measurements for most muscles and age groups are not well docu ... Cite

Single-fiber EMG demonstrates reinnervation dynamics after nerve injury.

Journal Article Neurology · July 1991 Serial single-fiber EMG (SF-EMG) studies in the frontalis muscle showed increased jitter with normal fiber density 15 days after facial nerve trauma. Both measurements were increased thereafter. The maximum increases occurred at 37 days, coincident with th ... Full text Link to item Cite

Recording characteristics of monopolar EMG electrodes.

Journal Article Muscle Nerve · February 1991 Motor unit action potentials (MUAPs) and the electromyographic (EMG) interference pattern (IP) were recorded from the biceps muscle of 5 normal subjects using both a concentric needle (CN) and a disposable monopolar needle (MN) electrode. The MUAPs recorde ... Full text Link to item Cite

On the shape of the normal turns--amplitude cloud.

Journal Article Muscle Nerve · January 1991 Factors that affect the shape of the so-called "normal cloud" of the turns and amplitude measurements of the electromyographic interference pattern are investigated. As the force of voluntary contraction increases from low to moderate levels, the number of ... Full text Link to item Cite

Personal-computer-based single-fibre EMG jitter analysis system.

Journal Article Med Biol Eng Comput · November 1990 Full text Link to item Cite

Recording and physical characteristics of disposable concentric needle EMG electrodes.

Journal Article Muscle Nerve · October 1990 There is currently considerable interest in using disposable concentric needle (CN) electrodes for clinical electromyography (EMG). To determine how these electrodes compare with reusable CN electrodes, we have compared signals recorded by these two electr ... Full text Link to item Cite

Measurement of the amplitude of the EMG envelope.

Journal Article Muscle Nerve · October 1990 When the force of muscle contraction is increased, the amplitude of the EMG envelope (ENAMP) increases. The ENAMP is usually assessed subjectively and its value in EMG analysis has been established. In this article we describe a method to make automatic me ... Full text Link to item Cite

Quantitative EMG in inflammatory myopathy.

Journal Article Muscle Nerve · March 1990 Fifty-four quantitative electromyographic (EMG) studies were made in 37 patients with inflammatory myopathy (IM) at different points in their clinical course and treatment. All studies were performed in the biceps brachii which varied in clinical strength. ... Full text Link to item Cite

Median averaging of electromyographic motor unit action potentials: comparison with other techniques

Journal Article Medical & Biological Engineering & Computing · November 1, 1989 A technique of extracting individual motor unit action potentials (MUAPs) from EMG signals by median averaging, a modification of an existing method, is presented. To compare different techniques of MUAP extraction, 89 MUAPs were recorded with a concentric ... Full text Cite