Allan Howard Friedman

Journal Article J Neurosurg Pediatr · April 1, 2024 OBJECTIVE: Relatively little is known about the safety and accuracy of catheter placement for oncolytic viral therapy in children with malignant brain tumors. Accordingly, this study combines data from two phase I clinical trials that employed viral immuno ... Full text Link to item Cite

Cognitive outcomes following aneurysmal subarachnoid hemorrhage: Rehabilitation strategies

Journal Article World Neurosurgery: X · April 1, 2024 Despite decreases in mortality rate, the treatment of cognitive deficits following aneurysmal subarachnoid hemorrhage (aSAH) remains a serious challenge for clinicians and survivors alike. Deficits in executive function, language, and memory prevent more t ... Full text Cite

Antithrombotic Therapy in Cerebral Cavernous Malformations: A Systematic Review, Meta-Analysis, and Network Meta-Analysis.

Journal Article J Am Heart Assoc · March 19, 2024 BACKGROUND: Cerebral cavernous malformations are complex vascular anomalies in the central nervous system associated with a risk of intracranial hemorrhage. Traditional guidelines have been cautious about the use of antithrombotic therapy in this patient g ... Full text Link to item Cite

High-resolution neural recordings improve the accuracy of speech decoding.

Journal Article Nat Commun · November 6, 2023 Patients suffering from debilitating neurodegenerative diseases often lose the ability to communicate, detrimentally affecting their quality of life. One solution to restore communication is to decode signals directly from the brain to enable neural speech ... Full text Link to item Cite

Recombinant polio-rhinovirus immunotherapy for recurrent paediatric high-grade glioma: a phase 1b trial.

Journal Article Lancet Child Adolesc Health · July 2023 BACKGROUND: Outcomes of recurrent paediatric high-grade glioma are poor, with a median overall survival of less than 6 months. Viral immunotherapy, such as the polio-rhinovirus chimera lerapolturev, is a novel approach for treatment of recurrent paediatric ... Full text Link to item Cite

Approaches to the Cerebellopontine Angle

Chapter · January 1, 2023 The cerebellopontine angle (CPA) is formed by the petrosal cerebellar surface, middle cerebellar peduncle, lateral pons, petrosal surface of the petrous bone, and clival portion of the occipital bone. While only accounting for 10–15% of intracranial tumors ... Full text Cite

Indication for a skull base approach in microvascular decompression for hemifacial spasm.

Journal Article Acta Neurochir (Wien) · December 2022 BACKGROUND: A thorough observation of the root exit zone (REZ) and secure transposition of the offending arteries is crucial for a successful microvascular decompression (MVD) for hemifacial spasm (HFS). Decompression procedures are not always feasible in ... Full text Link to item Cite

Retrolabyrinthine transsigmoid approach to complex parabrainstem tumors in the posterior fossa.

Journal Article J Neurosurg · April 1, 2022 OBJECTIVE: The surgical management of large and complex tumors of the posterior fossa poses a formidable challenge in neurosurgery. The standard retrosigmoid craniotomy approach has been performed at most neurosurgical centers; however, the retrosigmoid ap ... Full text Link to item Cite

Neurosurgery residency and fellowship education in the United States: 2 decades of system development by the One Neurosurgery Summit organizations.

Journal Article J Neurosurg · February 1, 2022 The purpose of this report is to chronicle a 2-decade period of educational innovation and improvement, as well as governance reform, across the specialty of neurological surgery. Neurological surgery educational and professional governance systems have ev ... Full text Link to item Cite

Long-Term Outcomes for Patients With Atypical or Malignant Meningiomas Treated With or Without Radiation Therapy: A 25-Year Retrospective Analysis of a Single-Institution Experience.

Journal Article Adv Radiat Oncol · 2022 PURPOSE: Atypical (World Health Organization [WHO] grade 2) and malignant (WHO grade 3) meningiomas have high rates of local recurrence, and questions remain about the role of adjuvant radiation therapy (RT) for patients with WHO grade 2 disease. These pat ... Full text Link to item Cite

Intraoperative microseizure detection using a high-density micro-electrocorticography electrode array.

Journal Article Brain Commun · 2022 One-third of epilepsy patients suffer from medication-resistant seizures. While surgery to remove epileptogenic tissue helps some patients, 30-70% of patients continue to experience seizures following resection. Surgical outcomes may be improved with more ... Full text Open Access Link to item Cite

Neurosurgical management of petrous bone lesions: classification system and selection of surgical approaches.

Journal Article Acta Neurochir (Wien) · October 2021 BACKGROUND: Surgery of petrous bone lesions (PBLs) is challenging for neurosurgeons. Selection of the surgical approach is an important key for success. In this study, the authors present an anatomical classification for PBLs that has been used by our grou ... Full text Link to item Cite

Petrous bone lesions: surgical implementation and outcomes of extradural subtemporal approach.

Journal Article Acta Neurochir (Wien) · October 2021 BACKGROUND: Petrous bone lesions (PBLs) are rare with few reports in the neurosurgical literature. In this study, the authors describe our current technique of extradural subtemporal approach (ESTA). The objective of this study was to evaluate the role and ... Full text Link to item Cite

How I do it: total resection of a giant sphenoclinoidal meningioma with normalization of near blind vision.

Journal Article Acta Neurochir (Wien) · September 2021 BACKGROUND: Resection of giant sphenoclinoidal meningiomas (SCLM) remains difficult. We discuss a patient presenting with right eye near blindness who underwent total removal of a giant SCLM, resulting in normal vision and no recurrence. METHOD: Utilizing ... Full text Link to item Cite

Flexible, high-resolution thin-film electrodes for human and animal neural research.

Journal Article J Neural Eng · June 17, 2021 Objective.Brain functions such as perception, motor control, learning, and memory arise from the coordinated activity of neuronal assemblies distributed across multiple brain regions. While major progress has been made in understanding the function of indi ... Full text Link to item Cite

Autograft-derived spinal cord mass in the cervical spine following transplantation with olfactory mucosa cells for traumatic spinal cord injury: case report.

Journal Article J Neurosurg Spine · February 1, 2021 This study describes a patient with an autograft-derived spinal cord mass following transplantation of olfactory mucosa for treatment of cervical spine injury. The authors report the case of a 35-year-old man who suffered a complete spinal cord injury (SCI ... Full text Link to item Cite

Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy.

Journal Article Nat Commun · January 13, 2021 Several immunotherapy clinical trials in recurrent glioblastoma have reported long-term survival benefits in 10-20% of patients. Here we perform genomic analysis of tumor tissue from recurrent WHO grade IV glioblastoma patients acquired prior to immunother ... Full text Open Access Link to item Cite

Masson's tumor presenting as a left frontal intraparenchymal hemorrhage resulting in severe expressive aphasia during pregnancy: case report.

Journal Article J Neurosurg · January 1, 2021 Intravascular papillary endothelial hyperplasia (IPEH), commonly known as Masson's tumor, is a benign lesion that manifests as an excessive proliferation of endothelial cells within a vessel wall. IPEH is extremely rare in the brain, with only 36 intracran ... Full text Link to item Cite

Perioperative Assessment of Cerebellar Masses and the Potential for Cerebellar Cognitive Affective Syndrome.

Journal Article World Neurosurg · December 2020 The cerebellum was long perceived to be a region of limited importance with primary functions in the regulation of motor control. A degree of its functional topography in motor modulation has been traditionally appreciated. However, an evolving body of evi ... Full text Link to item Cite

Eosinophilic globules in a classic ependymoma: evidence of a possible secretory role.

Journal Article Ultrastruct Pathol · November 20, 2020 A number of neoplasms of the central nervous system can demonstrate diffuse eosinophilic globules, known to be secretory products of the corresponding cell type, but they have not been a salient feature in descriptions of classic ependymoma. Here, we prese ... Full text Link to item Cite

Restarting Therapeutic Anticoagulation After Elective Craniotomy for Patients with Chronic Atrial Fibrillation: A Review of the Literature.

Journal Article World Neurosurg · May 2020 The decision to restart systemic anticoagulation after surgery requires a nuanced risk-benefit analysis. The potential for surgical site bleeding must be balanced against the risk of thromboembolic events. In the context of postoperative neurosurgical pati ... Full text Link to item Cite

T-cell lymphoblastic lymphoma involving the ocular adnexa: report of two cases and review of the current literature.

Journal Article Orbit · October 2019 The majority of ocular adnexal lymphomas are B-cell in origin. We report two cases of T-cell lymphoblastic lymphoma (T-LBL) involving the ocular adnexa. One patient presented with a painless pink conjunctival lesion and inferior orbital fullness. The secon ... Full text Link to item Cite

Novel Application of Steroid Eluting Stent in Petrous Apex Cholesterol Granuloma.

Journal Article J Neurol Surg B Skull Base · October 2019 Objective This study describes the safety and efficacy of mometasone furoate eluting stents in the management of petrous apex cholesterol granuloma approached through an endonasal endoscopic route and assesses the restenosis rate. Methods Consecutive pat ... Full text Link to item Cite

History of awake mapping and speech and language localization: from modules to networks.

Journal Article Neurosurg Focus · September 1, 2019 Lesion-symptom correlations shaped the early understanding of cortical localization. The classic Broca-Wernicke model of cortical speech and language organization underwent a paradigm shift in large part due to advances in brain mapping techniques. This in ... Full text Link to item Cite

Research Update in Neuroscience for Neurosurgeons: a historical perspective.

Journal Article J Neurosurg · August 1, 2019 Full text Link to item Cite

Attitudes and opinions of US neurosurgical residents toward research and scholarship: a national survey.

Journal Article J Neurosurg · July 1, 2019 OBJECTIVE: The analysis of resident research productivity in neurosurgery has gained significant recent interest. Resident scholarly output affects departmental productivity, recruitment of future residents, and likelihood of future research careers. To ma ... Full text Link to item Cite

MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation.

Journal Article Cancer Res · July 1, 2019 Homozygous deletion of methylthioadenosine phosphorylase (MTAP) is one of the most frequent genetic alterations in glioblastoma (GBM), but its pathologic consequences remain unclear. In this study, we report that loss of MTAP results in profound epigenetic ... Full text Link to item Cite

Single-institution retrospective review of patients with recurrent glioblastoma treated with bevacizumab in clinical practice.

Journal Article Health Sci Rep · April 2019 BACKGROUND AND AIMS: This retrospective review of patients with recurrent glioblastoma treated at the Preston Robert Tisch Brain Tumor Center investigated treatment patterns, survival, and safety with bevacizumab in a real-world setting. METHODS: Adult pat ... Full text Link to item Cite

MGMT: Immunohistochemical Detection in High-Grade Astrocytomas.

Journal Article J Neuropathol Exp Neurol · January 1, 2019 Glioma therapeutic resistance to alkylating chemotherapy is mediated via O6-methylguanine-DNA methyltransferase (MGMT). We hypothesized that a CD45/HAM56/MGMT double-stained cocktail would improve MGMT discrimination in tumor cells versus inflammatory and ... Full text Link to item Cite

Recurrent Glioblastoma Treated with Recombinant Poliovirus.

Journal Article N Engl J Med · July 12, 2018 BACKGROUND: The prognosis of patients with recurrent World Health Organization (WHO) grade IV malignant glioma is dismal, and there is currently no effective therapy. We conducted a dose-finding and toxicity study in this population of patients, evaluating ... Full text Link to item Cite

Masson's tumor of the pineal region: case report.

Journal Article J Neurosurg · June 2018 Intracranial intravascular papillary endothelial hyperplasia (IPEH), also referred to as Masson's tumor, is a condition that rarely occurs in the nervous system. IPEH most frequently occurs extracranially in the skin of the face, skull, neck, and trunk and ... Full text Link to item Cite

The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma.

Journal Article Nat Commun · May 25, 2018 The majority of glioblastomas can be classified into molecular subgroups based on mutations in the TERT promoter (TERTp) and isocitrate dehydrogenase 1 or 2 (IDH). These molecular subgroups utilize distinct genetic mechanisms of telomere maintenance, eithe ... Full text Link to item Cite

Lacrimal gland abscess in a child as a rare manifestation of IgG4-related disease.

Journal Article J AAPOS · February 2018 Dacryoadenitis is unusual in children, and noninfectious causes can be manifestations of serious undiagnosed systemic conditions. This report brings further attention to this rarely-encountered condition and emphasizes its association with IgG4-related dis ... Full text Link to item Cite

Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma.

Journal Article Cancer Res · January 1, 2018 Median survival for glioblastoma (GBM) remains <15 months. Human cytomegalovirus (CMV) antigens have been identified in GBM but not normal brain, providing an unparalleled opportunity to subvert CMV antigens as tumor-specific immunotherapy targets. A recen ... Full text Link to item Cite

Complications after glioma surgery

Chapter · January 1, 2018 To achieve optimal patient outcomes in brain tumor surgery, it is critical to know how to identify, manage and prevent common complications. From specific to broad, complications can be categorized as local, regional, or systemic. Local complications depen ... Full text Cite

Obituary. Robert H. Wilkins, MD, 1934-2017.

Journal Article J Neurosurg · December 2017 Full text Link to item Cite

In Memoriam: Robert H. Wilkins, MD, 1934 to 2017.

Journal Article Neurosurgery · July 1, 2017 Full text Link to item Cite

Long-term Survival in Glioblastoma with Cytomegalovirus pp65-Targeted Vaccination.

Journal Article Clin Cancer Res · April 15, 2017 Purpose: Patients with glioblastoma have less than 15-month median survival despite surgical resection, high-dose radiation, and chemotherapy with temozolomide. We previously demonstrated that targeting cytomegalovirus pp65 using dendritic cells (DC) can e ... Full text Link to item Cite

Rare Lesions of the Internal Auditory Canal.

Journal Article World Neurosurg · March 2017 BACKGROUND: Approximately 95% of tumors occurring within the internal auditory canal (IAC) are vestibular schwannomas. Many undergo stereotactic radiation without definitive tissue diagnosis. Rare IAC tumors are not all radiosensitive and are poorly descri ... Full text Link to item Cite

Mixed hemangioblastoma and ependymoma collision tumor of the cerebellum.

Journal Article Clin Neuropathol · 2017 Full text Link to item Cite

The Effect of Propofol vs. Isoflurane Anesthesia on Postoperative Changes in Cerebrospinal Fluid Cytokine Levels: Results from a Randomized Trial.

Journal Article Front Immunol · 2017 INTRODUCTION: Aside from direct effects on neurotransmission, inhaled and intravenous anesthetics have immunomodulatory properties. In vitro and mouse model studies suggest that propofol inhibits, while isoflurane increases, neuroinflammation. If these fin ... Full text Link to item Cite

Novel Hormone Receptors Present in Apocrine Cystadenoma of the Eyelid.

Journal Article Ophthalmic Plast Reconstr Surg · 2017 A 53-year-old woman presented with an apocrine cystadenoma of the right upper eyelid. Histologic examination revealed proliferating epithelial cells with apocrine snouts and occasional mitotic figures. Immunohistochemical analysis revealed a Ki-67 index of ... Full text Link to item Cite

Isolated Deep Ear Canal Pain: Possible Role of Auricular Branch of Vagus Nerve-Case Illustrations with Cadaveric Correlation.

Journal Article World Neurosurg · December 2016 UNLABELLED: Glossopharyngeal, nervus intermedius, and vagus neuralgias can all present with ear pain. However, to our knowledge, there have been no reports of otalgia as the only symptom of vagus neuralgia. The seventh, ninth, and tenth cranial nerves have ... Full text Link to item Cite

Microsurgical resection of vestibular schwannomas: complication avoidance.

Journal Article J Neurooncol · November 2016 Vestibular schwannoma (VS) surgery requires appropriate patient selection, meticulous microsurgical technique and optimal post-operative care. Focused radiation is an effective alternative for the treatment of smaller VSs. For VS surgery to remain a reason ... Full text Link to item Cite

The Effect of Propofol Versus Isoflurane Anesthesia on Human Cerebrospinal Fluid Markers of Alzheimer's Disease: Results of a Randomized Trial.

Journal Article J Alzheimers Dis · April 15, 2016 BACKGROUND: Preclinical studies have found differential effects of isoflurane and propofol on the Alzheimer's disease (AD)-associated markers tau, phosphorylated tau (p-tau) and amyloid-β (Aβ). OBJECTIVE: We asked whether isoflurane and propofol have diffe ... Full text Open Access Link to item Cite

Glioblastoma in the elderly: the effect of aggressive and modern therapies on survival.

Journal Article J Neurosurg · April 2016 OBJECTIVE: The prognosis of elderly patients with glioblastoma (GBM) is universally poor. Currently, few studies have examined postoperative outcomes and the effects of various modern therapies such as bevacizumab on survival in this patient population. In ... Full text Link to item Cite

Surgical management of vestibular schwannomas after failed radiation treatment.

Journal Article Neurosurg Rev · April 2016 Increasing numbers of patients with vestibular schwannoma (VS) have been treated with focused-beam stereotactic radiation treatment (SRT) including Gamma knife, CyberKnife, X-knife, Novalis, or proton beam therapy. The purpose of this study was to document ... Full text Link to item Cite

The Duke glioma handbook: Pathology, diagnosis, and management

Book · March 31, 2016 The management of patients with a glioma is challenging and best achieved by a team approach encompassing a combination of chemotherapy, radiotherapy, immunotherapy, and surgical excision in a specialist Cancer Center - the balance of treatment depending o ... Full text Cite

Glioma surgery

Chapter · March 31, 2016 Full text Cite

MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B.

Journal Article Cancer Cell · January 11, 2016 The hypoxic tumor microenvironment serves as a niche for maintaining the glioma-initiating cells (GICs) that are critical for glioblastoma (GBM) occurrence and recurrence. Here, we report that hypoxia-induced miR-215 is vital for reprograming GICs to fit t ... Full text Open Access Link to item Cite

Middle infratemporal fossa less invasive approach for radical resection of parapharyngeal tumors: surgical microanatomy and clinical application.

Journal Article Neurosurg Rev · January 2016 Surgery of the infratemporal fossa (ITF) and parapharyngeal area presents a formidable challenge to the surgeon due to its anatomical complexity and limited access. Conventional surgical approaches to these regions were often too invasive and necessitate s ... Full text Link to item Cite

Extradural Dermoid Cyst of the Anterior Infratemporal Fossa. Case Report.

Journal Article J Neurol Surg Rep · November 2015 Dermoid cysts are rare in the skull base. There have been 10 reported cases of dermoid cysts in the cavernous sinus, two in the petrous apex, and one in the extradural Meckel cave. This is the first case report of a dermoid cyst in the anterior infratempor ... Full text Link to item Cite

Central Nervous System Cancers, Version 1.2015.

Journal Article J Natl Compr Canc Netw · October 2015 The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Central Nervous System (CNS) Cancers provide interdisciplinary recommendations for managing adult CNS cancers. Primary and metastatic brain tumors are a heterogeneous group of neoplasm ... Full text Link to item Cite

Severe adverse immunologic reaction in a patient with glioblastoma receiving autologous dendritic cell vaccines combined with GM-CSF and dose-intensified temozolomide.

Journal Article Cancer Immunol Res · April 2015 Therapeutic vaccination of patients with cancer-targeting tumor-associated antigens is a promising strategy for the specific eradication of invasive malignancies with minimal toxicity to normal tissues. However, as increasingly potent modalities for stimul ... Full text Link to item Cite

Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients.

Journal Article Nature · March 19, 2015 After stimulation, dendritic cells (DCs) mature and migrate to draining lymph nodes to induce immune responses. As such, autologous DCs generated ex vivo have been pulsed with tumour antigens and injected back into patients as immunotherapy. While DC vacci ... Full text Open Access Link to item Cite

Impact of Tumor Histology on Resectability and Neurological Outcome in Primary Intramedullary Spinal Cord Tumors: A Single-Center Experience With 102 Patients.

Journal Article Neurosurgery · March 1, 2015 Full text Link to item Cite

The subtemporal approach to retroinfundibular craniopharyngiomas: A new look at an old approach

Journal Article Operative Neurosurgery · January 1, 2015 BACKGROUND: Retrochiasmatic, retroinfundibular craniopharyngiomas are surgically challenging tumors. Anterolateral, posterolateral, and endoscopic endonasal approaches represent the most commonly used techniques to access these tumors, but all require an e ... Full text Cite

Oncolytic polio virotherapy of cancer.

Journal Article Cancer · November 1, 2014 Recently, the century-old idea of targeting cancer with viruses (oncolytic viruses) has come of age, and promise has been documented in early stage and several late-stage clinical trials in a variety of cancers. Although originally prized for their direct ... Full text Link to item Cite

Central nervous system cancers, version 2.2014. Featured updates to the NCCN Guidelines.

Journal Article J Natl Compr Canc Netw · November 2014 The NCCN Guidelines for Central Nervous System Cancers provide multidisciplinary recommendations for the clinical management of patients with cancers of the central nervous system. These NCCN Guidelines Insights highlight recent updates regarding the manag ... Full text Link to item Cite

Morbidity, mortality, and health care costs for patients undergoing spine surgery following the ACGME resident duty-hour reform: Clinical article.

Journal Article J Neurosurg Spine · October 2014 OBJECT: The Accreditation Council for Graduate Medical Education (ACGME) implemented resident duty-hour restrictions on July 1, 2003, in concern for patient and resident safety. Whereas studies have shown that duty-hour restrictions have increased resident ... Full text Link to item Cite

miR-33a promotes glioma-initiating cell self-renewal via PKA and NOTCH pathways.

Journal Article J Clin Invest · October 2014 Glioblastoma (GBM) is the most common and lethal brain tumor in adults. Glioma-initiating cells (GICs) are stem-like cells that have been implicated in glioblastoma progression and recurrence; however, the distinct properties of GICs and non-GICs within GB ... Full text Link to item Cite

A novel, reproducible, and objective method for volumetric magnetic resonance imaging assessment of enhancing glioblastoma.

Journal Article J Neurosurg · September 2014 OBJECT: Robust methodology that allows objective, automated, and observer-independent measurements of brain tumor volume, especially after resection, is lacking. Thus, determination of tumor response and progression in neurooncology is unreliable. The obje ... Full text Link to item Cite

Malignant brainstem gliomas in adults: clinicopathological characteristics and prognostic factors.

Journal Article J Neurooncol · August 2014 Adult malignant brainstem gliomas (BSGs) are poorly characterized due to their relative rarity. We have examined histopathologically confirmed cases of adult malignant BSGs to better characterize the patient and tumor features and outcomes, including the n ... Full text Link to item Cite

Worse outcomes for patients undergoing brain tumor and cerebrovascular procedures following the ACGME resident duty-hour restrictions.

Journal Article J Neurosurg · August 2014 OBJECT: On July 1, 2003, the Accreditation Council for Graduate Medical Education (ACGME) implemented duty-hour restrictions for resident physicians due to concerns for patient and resident safety. Though duty-hour restrictions have increased resident qual ... Full text Link to item Cite

Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.

Journal Article Nat Genet · July 2014 Gliomas arising in the brainstem and thalamus are devastating tumors that are difficult to surgically resect. To determine the genetic and epigenetic landscape of these tumors, we performed exomic sequencing of 14 brainstem gliomas (BSGs) and 12 thalamic g ... Full text Link to item Cite

Hearing preservation surgery for vestibular schwannomas via the retrosigmoid transmeatal approach: surgical tips.

Journal Article Neurosurg Rev · July 2014 Maximum tumor extirpation with preservation of the facial and cochlear nerve function is the goal of surgery for vestibular schwannoma. To preserve cochlear nerve function, the surgeon must employ a detailed knowledge of microanatomy, precise microsurgical ... Full text Link to item Cite

Oncolytic polio/rhinovirus recombinant (pvsripo) in recurrent glioblastoma (gbm): first phase I clinical trial evaluating the intratumoral administration.

Journal Article Neuro Oncol · July 2014 PVSRIPO is the live attenuated, oral (SABIN) serotype 1 poliovirus vaccine containing a heterologous internal ribosomal entry site stemming from human rhinovirus type 2. PVSRIPO recognizes nectin-like molecule-5, an oncofetal cell adhesion molecule and tum ... Full text Link to item Cite

Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas.

Journal Article Oncotarget · March 30, 2014 Frequent mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) and the promoter of telomerase reverse transcriptase (TERT) represent two significant discoveries in glioma genomics. Understanding the degree to which these two mutations co-occur or o ... Full text Open Access Link to item Cite

The genetic landscape of anaplastic astrocytoma.

Journal Article Oncotarget · March 30, 2014 Anaplastic astrocytoma WHO grade III (A3) is a lethal brain tumor that often occurs in middle aged patients. Clinically, it is challenging to distinguish A3 from glioblastoma multiforme (GBM) WHO grade IV. To reveal the genetic landscape of this tumor type ... Full text Link to item Cite

Response.

Journal Article J Neurosurg · March 2014 Link to item Cite

Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas

Journal Article Nature Genetics · January 1, 2014 Gliomas arising in the brainstem and thalamus are devastating tumors that are difficult to surgically resect. To determine the genetic and epigenetic landscape of these tumors, we performed exomic sequencing of 14 brainstem gliomas (BSGs) and 12 thalamic g ... Full text Cite

Surgical management of nonvascular lesions around the oculomotor nerve.

Journal Article World Neurosurg · 2014 OBJECTIVE: Schwannomas originating from the oculomotor nerve are extremely rare. We report our experience in the management of oculomotor schwannomas and other lesions mimicking them, and discuss operative strategy for these rare tumors emphasizing oculomo ... Full text Link to item Cite

Cerebellopontine angle meningiomas: postoperative outcomes in a modern cohort.

Journal Article Neurosurg Focus · December 2013 OBJECT: Tumors of the cerebellopontine angle (CPA) have always proven difficult for neurosurgeons to optimally manage. Studies investigating the natural history and treatment of vestibular schwannomas have dominated the literature in this regard. Distingui ... Full text Link to item Cite

Chlamydia trachomatis masquerading as a chronic allergic conjunctivitis.

Journal Article Ocul Immunol Inflamm · December 2013 Full text Link to item Cite

Anatomical location dictating major surgical complications for intradural extramedullary spinal tumors: a 10-year single-institutional experience.

Journal Article J Neurosurg Spine · December 2013 OBJECT: Intradural extramedullary (IDEM) neoplasms are uncommon lesions that can pose a challenge for resection. Numerous factors affect the resectability and ultimately the outcome of these lesions. The authors report their 10-year institutional experienc ... Full text Link to item Cite

Levetiracetam seizure prophylaxis in craniotomy patients at high risk for postoperative seizures.

Journal Article Asian J Neurosurg · October 2013 BACKGROUND: The risk of developing immediate postoperative seizures in patients undergoing supratentorial brain tumor surgery without anti-epileptic drug (AED) prophylaxis is 15-20%. Patients who present with pre-operative seizures and patients with suprat ... Full text Link to item Cite

Less invasive transjugular approach with Fallopian bridge technique for facial nerve protection and hearing preservation in surgery of glomus jugulare tumors.

Journal Article Neurosurg Rev · October 2013 For the past three decades, surgery of glomus jugulare tumors (GJTs) has been characterized by extensive combined head and neck, neuro-otologic, and neurosurgical approaches. In recent years, the authors have modified the operative technique to a less inva ... Full text Link to item Cite

Clinical characteristics and treatment of malignant brainstem gliomas in elderly patients.

Journal Article J Clin Neurosci · October 2013 Adult brainstem gliomas (BSG) are uncommon tumors that constitute only 2% of all brain tumors. Due to its rare occurrence in the elderly (60 years and older), there is no literature discussing the natural history, prognosis, and best treatment strategy for ... Full text Link to item Cite

Central nervous system cancers.

Journal Article J Natl Compr Canc Netw · September 1, 2013 Primary and metastatic tumors of the central nervous system are a heterogeneous group of neoplasms with varied outcomes and management strategies. Recently, improved survival observed in 2 randomized clinical trials established combined chemotherapy and ra ... Full text Link to item Cite

Comparison of postoperative nausea between benign and malignant brain tumor patients undergoing awake craniotomy: a retrospective analysis.

Journal Article Curr Med Res Opin · September 2013 BACKGROUND: Benign and malignant brain tumors have different histopathological characteristics, including different degrees of tissue infiltration and inflammatory response. The aim of this retrospective study was to compare the incidence of postoperative ... Full text Link to item Cite

Does midline shift predict postoperative nausea in brain tumor patients undergoing awake craniotomy? A retrospective analysis.

Journal Article Curr Med Res Opin · September 2013 BACKGROUND: The presence of midline shift on neuroradiologic studies in brain tumor patients represents mass effect from the tumor and surrounding edema. We hypothesized that baseline cerebral edema as measured by midline shift would increase postoperative ... Full text Link to item Cite

Low-grade astrocytomas: the prognostic value of fibrillary, gemistocytic, and protoplasmic tumor histology.

Journal Article J Neurosurg · August 2013 OBJECT: Low-grade astrocytomas are slow-growing, infiltrative gliomas that over time may progress into more malignant tumors. Various factors have been shown to affect the time to progression and overall survival including age, performance status, tumor si ... Full text Link to item Cite

Outcome and prognostic factors in adult cerebellar glioblastoma.

Journal Article J Clin Neurosci · August 2013 Cerebellar glioblastoma multiforme (GBM) occurs rarely in adults, accounting for 0.4-3.4% of all GBM. Current studies have all involved small patient numbers, limiting the clear identification of prognostic factors. Additionally, while few studies have com ... Full text Link to item Cite

107 Dose-finding and safety study of an oncolytic polio/rhinovirus recombinant against recurrent glioblastoma.

Journal Article Neurosurgery · August 2013 Current therapies for glioblastoma are limited by ineffective delivery beyond the blood-brain barrier, limited diffusion of regionally-delivered macromolecules, and lack of tumor specificity. Sustained direct intracerebral infusion at slow flow rates [conv ... Full text Link to item Cite

Clinicopathological characteristics and treatment of rhabdoid glioblastoma.

Journal Article J Neurosurg · August 2013 OBJECT: Rhabdoid glioblastoma (GB) is an exceedingly rare tumor in which some of the tumor cells possess rhabdoid features such as eccentric nuclei, abundant eosinophilic cytoplasm, and pseudopapillary formations. These tumors are exceptionally aggressive, ... Full text Link to item Cite

An outbreak of fungal endophthalmitis after intravitreal injection of compounded combined bevacizumab and triamcinolone.

Journal Article JAMA Ophthalmol · July 2013 IMPORTANCE: Our experience may be useful to other practitioners using compounded intravitreal agents, those suspecting infectious outbreaks, and those managing fungal endophthalmitis. OBJECTIVE: To describe a series of patients with fungal endophthalmitis ... Full text Link to item Cite

Vestibular schwannomas in the modern era: epidemiology, treatment trends, and disparities in management.

Journal Article J Neurosurg · July 2013 OBJECT: There are a variety of treatment options for the management of vestibular schwannomas (VSs), including microsurgical resection, radiotherapy, and observation. Although the choice of treatment is dependent on various patient factors, physician bias ... Full text Link to item Cite

Contemporary surgical management of vestibular schwannomas: analysis of complications and lessons learned over the past decade.

Journal Article Neurosurgery · June 2013 BACKGROUND: Despite advanced microsurgical techniques, more refined instrumentation, and expert team management, there is still a significant incidence of complications in vestibular schwannoma surgery. OBJECTIVE: To analyze complications from the microsur ... Full text Link to item Cite

Long-term economic impact of coiling vs clipping for unruptured intracranial aneurysms.

Journal Article Neurosurgery · June 2013 BACKGROUND: : Treatment of unruptured intracranial aneurysms (UIAs) involves endovascular coiling or aneurysm clipping. While many studies have compared these treatment modalities with respect to various clinical outcomes, few studies have investigated the ... Full text Link to item Cite

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.

Journal Article Proc Natl Acad Sci U S A · April 9, 2013 Malignant cells, like all actively growing cells, must maintain their telomeres, but genetic mechanisms responsible for telomere maintenance in tumors have only recently been discovered. In particular, mutations of the telomere binding proteins alpha thala ... Full text Link to item Cite

Middle fossa approach for total resection of petrous apex cholesterol granulomas: use of vascularized galeofascial flap preventing recurrence.

Journal Article Neurosurgery · March 2013 BACKGROUND: Cholesterol granulomas (CGs) of the petrous apex (PA) are rare, benign, expanding lesions. Surgical treatment is recommended for patients with symptomatic disease; however, the optimal surgical procedure is still controversial due to high recur ... Full text Link to item Cite

A comprehensive analysis of 41 patients with rosette-forming glioneuronal tumors of the fourth ventricle.

Journal Article J Clin Neurosci · March 2013 The rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle is a recently described, rare, and distinct tumor of the glioneuronal family. The presentation, natural history, and treatment response of these tumors has been unclear as there are no s ... Full text Link to item Cite

Thickness of subcutaneous fat as a risk factor for infection in cervical spine fusion surgery.

Journal Article J Bone Joint Surg Am · February 20, 2013 BACKGROUND: Surgical site infections increase the incidence of morbidity and mortality as well as health-care expenses. The cost of care increases threefold to fourfold as a consequence of surgical site infection after spinal surgery. The aim of the presen ... Full text Link to item Cite

Improved survival in the largest national cohort of adults with cerebellar versus supratentorial low-grade astrocytomas.

Journal Article Neurosurg Focus · February 2013 OBJECT: Low-grade gliomas (LGGs) are indolent tumors that have the potential to dedifferentiate into malignant high-grade tumors. Recent studies have demonstrated that cerebellar low-grade tumors have a better prognosis than supratentorial tumors, although ... Full text Link to item Cite

Evaluation of variation in the course of the facial nerve, nerve adhesion to tumors, and postoperative facial palsy in acoustic neuroma.

Journal Article J Neurol Surg B Skull Base · February 2013 Objective To investigate the variation in the course of the facial nerve (FN) in patients undergoing acoustic neuroma (AN) surgery, its adhesion to tumors, and the relationship between such adhesions and postoperative facial palsy. Methods The subjects wer ... Full text Link to item Cite

Convection enhanced delivery of macromolecules for brain tumors.

Journal Article Curr Drug Discov Technol · December 2012 The blood brain barrier (BBB) poses a significant challenge for drug delivery of macromolecules into the brain. Convection-enhanced delivery (CED) circumvents the BBB through direct intracerebral infusion using a hydrostatic pressure gradient to transfer t ... Full text Link to item Cite

Bevacizumab continuation beyond initial bevacizumab progression among recurrent glioblastoma patients.

Journal Article Br J Cancer · October 23, 2012 BACKGROUND: Bevacizumab improves outcome for most recurrent glioblastoma patients, but the duration of benefit is limited and survival after initial bevacizumab progression is poor. We evaluated bevacizumab continuation beyond initial progression among rec ... Full text Open Access Link to item Cite

Preauricular transzygomatic anterior infratemporal fossa approach for tumors in or around infratemporal fossa lesions.

Journal Article Neurosurg Rev · October 2012 Various surgical approaches to the infratemporal fossa (ITF) have been reported. Among them, the preauricular transzygomatic anterior ITF approach (anterior ITF approach) has been used for exposure of the antero-superior part of the ITF. The purpose of thi ... Full text Link to item Cite

Calcifying pseudoneoplasms of the skull base presenting with cranial neuropathies: case report and literature review.

Journal Article J Neurol Surg Rep · October 2012 Objectives We report our institutional experience with calcifying pseudoneoplasms of the skull base that presented with cranial neuropathies. These lesions are also known as fibro-osseous lesions, cerebral calculi, or brain stones. Results One patient pres ... Full text Link to item Cite

2012 Young Investigator Award winner: The distribution of body mass as a significant risk factor for lumbar spinal fusion postoperative infections.

Journal Article Spine (Phila Pa 1976) · September 1, 2012 STUDY DESIGN: A retrospective review. OBJECTIVE: The purpose of this study was to determine the role in body habitus and weight distribution on developing a surgical site infection (SSI). SUMMARY OF BACKGROUND DATA: SSI after lumbar spine surgery remains a ... Full text Link to item Cite

Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas.

Journal Article Oncotarget · July 2012 Mutations in the critical chromatin modifier ATRX and mutations in CIC and FUBP1, which are potent regulators of cell growth, have been discovered in specific subtypes of gliomas, the most common type of primary malignant brain tumors. However, the frequen ... Full text Open Access Link to item Cite

Thrombin and hemin as central factors in the mechanisms of intracerebral hemorrhage-induced secondary brain injury and as potential targets for intervention.

Journal Article Neurosurg Focus · April 2012 Intracerebral hemorrhage (ICH) is a subtype of stoke that may cause significant morbidity and mortality. Brain injury due to ICH initially occurs within the first few hours as a result of mass effect due to hematoma formation. However, there is increasing ... Full text Link to item Cite

The use of motor mapping to aid resection of eloquent gliomas.

Journal Article Neurosurg Clin N Am · April 2012 Surgery remains one of the oldest and still most important forms of treatment for patients with glioma. The advantages of surgical resection for glioma must be balanced with the potential of operative morbidity to surrounding eloquent brain. To that end, a ... Full text Link to item Cite

Comments

Journal Article Neurosurgery · April 1, 2012 Full text Cite

Phase II study of carboplatin, irinotecan, and bevacizumab for bevacizumab naïve, recurrent glioblastoma.

Journal Article J Neurooncol · March 2012 Featured Publication We evaluated the efficacy of carboplatin, irinotecan, and bevacizumab among bevacizumab-naïve, recurrent glioblastoma (GBM) patients in a phase 2, open-label, single arm trial. Forty eligible patients received carboplatin (area under the plasma curve [AUC] ... Full text Link to item Cite

Tentorial detachment technique in the combined petrosal approach for petroclival meningiomas.

Journal Article J Neurosurg · March 2012 Featured Publication OBJECT: The combined petrosal approach is a suitable technique for the resection of medium-to-large petroclival meningiomas (PCMs). Multiple technical modifications have been reported to increase the surgical corridor, including the method of dural and ten ... Full text Link to item Cite

Trigeminal schwannomas: skull base approaches and operative results in 105 patients.

Journal Article Neurosurgery · March 2012 Featured Publication BACKGROUND: Trigeminal schwannomas make up 0.8% to 8% of all intracranial schwannomas. OBJECTIVE: To analyze our surgical experience with trigeminal schwannomas. METHODS: We performed 107 operations on 105 patients harboring trigeminal schwannomas over the ... Full text Link to item Cite

Addition of bevacizumab to standard radiation therapy and daily temozolomide is associated with minimal toxicity in newly diagnosed glioblastoma multiforme.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2012 PURPOSE: To determine the safety of the addition of bevacizumab to standard radiation therapy and daily temozolomide for newly diagnosed glioblastoma multiforme (GBM). METHODS AND MATERIALS: A total of 125 patients with newly diagnosed GBM were enrolled in ... Full text Link to item Cite

A pilot study of IL-2Rα blockade during lymphopenia depletes regulatory T-cells and correlates with enhanced immunity in patients with glioblastoma.

Journal Article PLoS One · 2012 BACKGROUND: Preclinical studies in mice have demonstrated that the prophylactic depletion of immunosuppressive regulatory T-cells (T(Regs)) through targeting the high affinity interleukin-2 (IL-2) receptor (IL-2Rα/CD25) can enhance anti-tumor immunotherapy ... Full text Open Access Link to item Cite

Trigeminal schwannomas: skull base approaches and operative results in 105 patients.

Journal Article Neurosurgery · January 1, 2012 Trigeminal schwannomas make up 0.8% to 8% of all intracranial schwannomas. To analyze our surgical experience with trigeminal schwannomas. We performed 107 operations on 105 patients harboring trigeminal schwannomas over the past 30 years. We classified th ... Cite

Microsurgical management of hypoglossal schwannomas over 3 decades: a modified grading scale to guide surgical approach.

Journal Article Neurosurgery · December 2011 Featured Publication BACKGROUND: Schwannomas originating from the hypoglossal nerve are extremely rare. Microsurgical resection with the goal for cure has traditionally been associated with a high risk of postoperative deficits. OBJECTIVE: To summarize our clinical experience ... Full text Link to item Cite

Phase 2 study of carboplatin, irinotecan, and bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy.

Journal Article Cancer · December 1, 2011 BACKGROUND: The efficacy of carboplatin, irinotecan, and bevacizumab among recurrent glioblastoma (GBM) patients after prior progression on bevacizumab therapy in a phase 2, open-label, single-arm trial was evaluated. METHODS: Eligible patients received ca ... Full text Link to item Cite

A phase I trial of the farnesyl transferase inhibitor, SCH 66336, with temozolomide for patients with malignant glioma.

Journal Article J Neurooncol · December 2011 We conducted a phase I clinical trial of the combination of SCH 66336 with temozolomide administered on the standard 5-day dosing schedule. The primary objective was to determine the maximum tolerated dose and dose limiting toxicity (DLT) of twice daily SC ... Full text Link to item Cite

Comments

Journal Article Neurosurgery · December 1, 2011 Full text Cite

Monoclonal antibody blockade of IL-2 receptor α during lymphopenia selectively depletes regulatory T cells in mice and humans.

Journal Article Blood · September 15, 2011 Lymphodepletion augments adoptive cell transfer during antitumor immunotherapy, producing dramatic clinical responses in patients with malignant melanoma. We report that the lymphopenia induced by the chemotherapeutic agent temozolomide (TMZ) enhances vacc ... Full text Link to item Cite

Midsubtemporal ridge as a predictor of the lateral loop formed by the maxillary nerve and mandibular nerve: a cadaveric morphological study.

Journal Article Neurosurgery · September 2011 BACKGROUND: The lateral loop formed by the maxillary nerve (V2) and the mandibular nerve (V3) consists of a part of the far lateral triangle of the cavernous sinus. Because this triangle becomes a surgical corridor of the preauricular infratemporal fossa a ... Full text Link to item Cite

Convection-enhanced delivery.

Journal Article J Neurosurg · September 2011 Full text Link to item Cite

Colocalization of gadolinium-diethylene triamine pentaacetic acid with high-molecular-weight molecules after intracerebral convection-enhanced delivery in humans.

Journal Article Neurosurgery · September 2011 BACKGROUND: Convection-enhanced delivery (CED) permits site-specific therapeutic drug delivery within interstitial spaces at increased dosages through circumvention of the blood-brain barrier. CED is currently limited by suboptimal methodologies for monito ... Full text Link to item Cite

Calcifying pseudoneoplasm of the cerebellopontine angle: case report.

Journal Article Neurosurgery · September 2011 BACKGROUND AND IMPORTANCE: Calcifying pseudoneoplasms are rare tumors of the neuraxis. To our knowledge, this is only the second reported case in the literature of calcifying pseudoneoplasm of the cerebellopontine angle. The etiology and natural history of ... Full text Link to item Cite

Epidemiology.

Journal Article J Neurosurg · August 2011 Full text Link to item Cite

Exercise behavior, functional capacity, and survival in adults with malignant recurrent glioma.

Journal Article J Clin Oncol · July 20, 2011 PURPOSE: Identifying strong markers of prognosis are critical to optimize treatment and survival outcomes in patients with malignant recurrent glioma. We investigated the prognostic significance of exercise behavior and functional capacity in this populati ... Full text Link to item Cite

The addition of bevacizumab to standard radiation therapy and temozolomide followed by bevacizumab, temozolomide, and irinotecan for newly diagnosed glioblastoma.

Journal Article Clin Cancer Res · June 15, 2011 PURPOSE: To determine if the addition of bevacizumab to radiation therapy and temozolomide, followed by bevacizumab, temozolomide, and irinotecan, for newly diagnosed glioblastoma patients is safe and effective. EXPERIMENTAL DESIGN: A total of 75 patients ... Full text Link to item Cite

Phase II study of metronomic chemotherapy with bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy.

Journal Article J Neurooncol · June 2011 Featured Publication We evaluated the efficacy of metronomic etoposide or temozolomide administered with bevacizumab among recurrent glioblastoma (GBM) patients who progressed on prior bevacizumab therapy in a phase 2, open-label, two-arm trial. Twenty-three patients received ... Full text Link to item Cite

A review of VEGF/VEGFR-targeted therapeutics for recurrent glioblastoma.

Journal Article J Natl Compr Canc Netw · April 2011 Glioblastoma, the most common primary malignant brain tumor among adults, is a highly angiogenic and deadly tumor. Angiogenesis in glioblastoma, driven by hypoxia-dependent and independent mechanisms, is primarily mediated by vascular endothelial growth fa ... Full text Link to item Cite

Central nervous system cancers.

Journal Article J Natl Compr Canc Netw · April 2011 Full text Link to item Cite

Monitoring radiographic brain tumor progression.

Journal Article Toxins (Basel) · March 2011 Determining radiographic progression in primary malignant brain tumors has posed a significant challenge to the neuroncology community. Glioblastoma multiforme (GBM, WHO Grade IV) through its inherent heterogeneous enhancement, growth patterns, and irregul ... Full text Link to item Cite

Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma.

Journal Article Neuro Oncol · March 2011 Featured Publication Epidermal growth factor receptor variant III (EGFRvIII) is a tumor-specific mutation widely expressed in glioblastoma multiforme (GBM) and other neoplasms, but absent from normal tissues. Immunotherapeutic targeting of EGFRvIII could eliminate neoplastic c ... Full text Link to item Cite

Imaging of convection enhanced delivery of toxins in humans.

Journal Article Toxins (Basel) · March 2011 Drug delivery of immunotoxins to brain tumors circumventing the blood brain barrier is a significant challenge. Convection-enhanced delivery (CED) circumvents the blood brain barrier through direct intracerebral application using a hydrostatic pressure gra ... Full text Link to item Cite

A novel method for volumetric MRI response assessment of enhancing brain tumors.

Journal Article PLoS One · January 26, 2011 Current radiographic response criteria for brain tumors have difficulty describing changes surrounding postoperative resection cavities. Volumetric techniques may offer improved assessment, however usually are time-consuming, subjective and require expert ... Full text Link to item Cite

Fourth ventricular schwannoma: identical clinicopathologic features as schwann cell-derived schwannoma with unique etiopathologic origins.

Journal Article Case Rep Med · 2011 Background. To our knowledge, this is the sixth reported case in the literature of fourth ventricular schwannoma. The etiology and natural history of intraventricular schwannomas is not well understood. A thorough review of potential etiopathogenic mechani ... Full text Link to item Cite

Impact of tumor histology on resectability and neurological outcome in primary intramedullary spinal cord tumors: a single-center experience with 102 patients.

Journal Article Neurosurgery · January 2011 BACKGROUND: Surgical outcomes for intramedullary spinal cord tumors are affected by many variables including tumor histology and preoperative neurological function. OBJECTIVE: To analyze the impact of tumor histology on neurological outcome in primary intr ... Full text Link to item Cite

Effect of CYP3A-inducing anti-epileptics on sorafenib exposure: results of a phase II study of sorafenib plus daily temozolomide in adults with recurrent glioblastoma.

Journal Article J Neurooncol · January 2011 Sorafenib, an oral VEGFR-2, Raf, PDGFR, c-KIT and Flt-3 inhibitor, is active against renal cell and hepatocellular carcinomas, and has recently demonstrated promising activity for lung and breast cancers. In addition, various protracted temozolomide dosing ... Full text Link to item Cite

Response

Journal Article Journal of Neurosurgery · December 1, 2010 Full text Cite

Intraoperative floppy iris syndrome: report of a case and histopathologic analysis.

Journal Article Arch Ophthalmol · November 2010 OBJECTIVE: To understand the role of the α(1A)-adrenoreceptors (ARs) in the pathophysiologic mechanism of intraoperative floppy iris syndrome (IFIS). METHODS: Iris specimens from a patient with tamsulosin hydrochloride-induced IFIS were obtained during tra ... Full text Link to item Cite

Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma.

Journal Article J Clin Oncol · November 1, 2010 PURPOSE: Immunologic targeting of tumor-specific gene mutations may allow precise eradication of neoplastic cells without toxicity. Epidermal growth factor receptor variant III (EGFRvIII) is a constitutively activated and immunogenic mutation not expressed ... Full text Link to item Cite

Comments

Journal Article Neurosurgical Review · October 1, 2010 Full text Cite

Critical assessment of operative approaches for hearing preservation in small acoustic neuroma surgery: retrosigmoid vs middle fossa approach.

Journal Article Neurosurgery · September 2010 Featured Publication BACKGROUND: For hearing preservation in acoustic neuroma (AN) surgery, the middle fossa (MF) or retrosigmoid (RS) approach can be used. Recent literature advocates the use of the MF approach, especially for small ANs. OBJECTIVE: To present our critical ana ... Full text Link to item Cite

Ophthalmic findings in a patient with CD8-positive T cell lymphoma and a hydroa vacciniforme-like eruption.

Journal Article Br J Ophthalmol · September 2010 Full text Link to item Cite

Combined microsurgical and endovascular treatment of a giant left middle cerebral artery aneurysm.

Journal Article J Neurointerv Surg · September 2010 Giant fusiform aneurysms of the middle cerebral artery (MCA) bifurcation pose significant treatment challenges. A giant fusiform aneurysm of the left MCA in a pediatric patient, which persisted despite Hunterian ligation of the M1 and double barrel superfi ... Full text Link to item Cite

Unilateral hypoglossal nerve palsy caused by an intraneural ganglion cyst.

Journal Article J Neurosurg · August 2010 Featured Publication The authors describe a rare case of unilateral hypoglossal nerve palsy caused by an intraneural ganglion cyst. Three similar cases have been reported with pathological classification still under consideration. One case was classified as an intraneural gang ... Full text Link to item Cite

Poor drug distribution as a possible explanation for the results of the PRECISE trial.

Journal Article J Neurosurg · August 2010 OBJECT: Convection-enhanced delivery (CED) is a novel intracerebral drug delivery technique with considerable promise for delivering therapeutic agents throughout the CNS. Despite this promise, Phase III clinical trials employing CED have failed to meet cl ... Full text Link to item Cite

Surgical management of brainstem cavernomas: selection of approaches and microsurgical techniques.

Journal Article Neurosurg Rev · July 2010 This study reviewed surgical experience with brainstem cavernomas in an attempt to define optimal surgical approaches and risks associated with surgical management. Clinical courses were retrospectively reviewed for 36 consecutive patients (12 men, 24 wome ... Full text Link to item Cite

Retrosigmoid suprafloccular transhorizontal fissure approach for resection of brainstem cavernous malformation.

Journal Article Neurosurgery · June 2010 OBJECTIVE: This study examined the usefulness of a surgical approach (retrosigmoid suprafloccular transhorizontal fissure approach) for resection of brainstem cavernous malformations (CMs). METHODS: An anatomic study concerning the retrosigmoid suprafloccu ... Full text Link to item Cite

Skull base training and education using an artificial skull model created by selective laser sintering.

Journal Article Acta Neurochir (Wien) · June 2010 Featured Publication INTRODUCTION: Practicing skull base approaches on cadavers affords the surgeon a chance to learn complex anatomical relationships and to practice surgical skills. However, there are ethical or legal problems in obtaining cadaver material in some countries. ... Full text Link to item Cite

Is the rate of congenital heart defects detected by fetal echocardiography among pregnancies conceived by in vitro fertilization really increased?: a case-historical control study.

Journal Article J Ultrasound Med · June 2010 OBJECTIVE: We investigated the prenatal prevalence of congenital heart defects (CHDs) among in vitro fertilization (IVF) pregnancies at a referral program in the United States. METHODS: Study patients were referred for fetal echocardiography between April ... Full text Link to item Cite

Comments

Journal Article Neurosurgery · May 1, 2010 Full text Cite

Timing of symptomatic vasospasm in aneurysmal subarachnoid hemorrhage: the effect of treatment modality and clinical implications.

Journal Article J Stroke Cerebrovasc Dis · March 2010 A better prediction of the time course of symptomatic vasospasm (SVSP) might have a significant impact on the management and prevention of delayed neurologic ischemic deficit (DIND). We studied the influence of the treatment for ruptured aneurysm on SVSP t ... Full text Link to item Cite

Quantitative assessment of cardiorespiratory fitness, skeletal muscle function, and body composition in adults with primary malignant glioma.

Journal Article Cancer · February 1, 2010 BACKGROUND: The study was undertaken to evaluate cardiorespiratory fitness, skeletal muscle function, and body composition of patients with newly diagnosed and untreated, postsurgical primary malignant glioma. METHODS: By using a cross-sectional design, pa ... Full text Link to item Cite

Phase 2 trial of erlotinib plus sirolimus in adults with recurrent glioblastoma.

Journal Article J Neurooncol · January 2010 We evaluated the anti-tumor activity and safety of erlotinib, a receptor tyrosine kinase inhibitor of the epidermal growth factor receptor, plus sirolimus, an inhibitor of the mammalian target of rapamycin, among patients with recurrent glioblastoma (GBM) ... Full text Link to item Cite

Chemopotentiation by ultrafractionated radiotherapy in glioblastoma resistant to conventional therapy.

Journal Article Tumori · 2010 INTRODUCTION: Induced radiation resistance (IRR) and hyper-radiosensitivity (HRS) are well-described phenomena in basic literature, yet few reports have been published in which such phenomena are exploited clinically for the benefit of patients. Glioblasto ... Full text Link to item Cite

Changes in functional performance measures in adults undergoing chemoradiation for primary malignant glioma: a feasibility study.

Journal Article Oncologist · 2010 PURPOSE: To investigate the feasibility of longitudinal assessment of functional performance measures in newly diagnosed postsurgical malignant glioma patients. METHODS: Patients with histologically confirmed, clinically stable, postsurgical, and previousl ... Full text Link to item Cite

Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study.

Journal Article Br J Cancer · December 15, 2009 BACKGROUND: We evaluated bevacizumab with metronomic etoposide among recurrent malignant glioma patients in a phase 2, open-label trial. METHODS: A total of 59 patients, including 27 with glioblastoma (GBM) and 32 with grade 3 malignant glioma, received 10 ... Full text Open Access Link to item Cite

Phase II trial of temozolomide (TMZ) plus irinotecan (CPT-11) in adults with newly diagnosed glioblastoma multiforme before radiotherapy.

Journal Article J Neurooncol · December 2009 This phase II trial evaluated efficacy and safety of temozolomide (TMZ) in combination with irinotecan (CPT-11) before radiotherapy in patients with newly diagnosed glioblastoma multiforme (GBM). Prior to radiotherapy, patients were treated with a maximum ... Full text Link to item Cite

Simple identification of the third segment of the extracranial vertebral artery by extreme lateral inferior transcondylar-transtubercular exposure (ELITE).

Journal Article Acta Neurochir (Wien) · November 2009 PURPOSE: The exposure of the third segment of the extracranial vertebral artery (V3) is an important step in the extreme lateral inferior transcondylar-transtubercular exposure (ELITE) approach. The muscular suboccipital triangle provides one of the landma ... Full text Link to item Cite

Alpha1-adrenergic blockers and intraoperative floppy-iris syndrome.

Journal Article Arch Ophthalmol · November 2009 Full text Link to item Cite

An Eclectic Review of the History of Peripheral Nerve Surgery.

Journal Article Neurosurgery · October 1, 2009 Full text Link to item Cite

Tinzaparin prophylaxis against venous thromboembolic complications in brain tumor patients.

Journal Article J Neurooncol · October 2009 The purpose of this study was to determine the safety of tinzaparin for deep vein thrombosis prophylaxis in newly diagnosed grade III-IV malignant glioma patients. Patients were initiated on daily tinzaparin at a fixed dose of 4,500 IU subcutaneously betwe ... Full text Link to item Cite

Hearing preservation in surgery for large vestibular schwannomas.

Journal Article J Neurosurg · October 2009 Featured Publication OBJECT: Hearing preservation remains a challenging problem in vestibular schwannoma (VS) surgery. The ability to preserve hearing in patients with large tumors is subject to particular difficulty. In this study, the authors focus on hearing preservation in ... Full text Link to item Cite

An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme.

Journal Article Mol Cancer Ther · October 2009 Featured Publication Conventional therapies for glioblastoma multiforme (GBM) fail to target tumor cells exclusively, such that their efficacy is ultimately limited by nonspecific toxicity. Immunologic targeting of tumor-specific gene mutations, however, may allow more precise ... Full text Link to item Cite

Phase I trial of temozolomide plus O6-benzylguanine 5-day regimen with recurrent malignant glioma.

Journal Article Neuro Oncol · October 2009 This phase I clinical trial conducted with patients who had recurrent or progressive malignant glioma (MG) was designed to determine the maximum tolerated dose (MTD) and toxicity of three different 5-day dosing regimens of temozolomide (TMZ) in combination ... Full text Link to item Cite

The association of breast cancer and meningioma in men and women: Commentary

Journal Article Neurosurgery · September 1, 2009 Full text Cite

Overall survival of newly diagnosed glioblastoma patients receiving carmustine wafers followed by radiation and concurrent temozolomide plus rotational multiagent chemotherapy.

Journal Article Cancer · August 1, 2009 Featured Publication BACKGROUND: Glioblastoma multiforme (GBM), the most lethal type of brain tumor, has a 1-year median survival. The effect of carmustine wafers on the survival of newly diagnosed GBM patients treated with radiotherapy (RT) and concurrent temozolomide (TMZ) p ... Full text Link to item Cite

Assessment of physical functioning in recurrent glioma: preliminary comparison of performance status to functional capacity testing.

Journal Article J Neurooncol · August 2009 BACKGROUND: Performance status (PS) scoring systems are tools of immense clinical importance in the management of patients with malignant disease but these tools are subjective and do not provide an objective evaluation of physical functioning. We conducte ... Full text Link to item Cite

Computerized assessment of vessel morphological changes during treatment of glioblastoma multiforme: report of a case imaged serially by MRA over four years.

Journal Article Neuroimage · August 2009 A patient with glioblastoma multiforme underwent serial computerized analysis of tumor-associated vasculature defined from magnetic resonance angiographic (MRA) scans obtained over almost a four year period. The clinical course included tumor resection wit ... Full text Link to item Cite

Tamsulosin and the intraoperative floppy iris syndrome.

Journal Article JAMA · May 20, 2009 Full text Link to item Cite

A successful pregnancy outcome following the Ross procedure: a case report.

Journal Article Am J Perinatol · April 2009 For women requiring valve replacement surgery, it is unclear which type of valve offers the greatest chance of a healthy pregnancy. This case describes a successful pregnancy outcome following the Ross procedure, which involves replacing the aortic valve w ... Full text Link to item Cite

Impact of ruptured cerebral aneurysm coiling and clipping on the incidence of cerebral vasospasm and clinical outcome.

Journal Article J Neuroimaging · April 2009 BACKGROUND: This study assessed the impact of treatment modality of aneurysmal subarachnoid hemorrhage (aSAH) on the rate of vasospasm (VSP), mortality, and hospital length of stay (LOS) of patients with aneurysmal subarachnoid hemorrhage (aSAH). METHODS: ... Full text Link to item Cite

Primary intramedullary melanocytoma of the spinal cord: case report.

Journal Article Neurosurgery · April 2009 OBJECTIVE: The authors report 2 cases of primary intramedullary spinal melanocytomas in 2 patients who presented with lower extremity numbness and/or weakness. CLINICAL PRESENTATION: Magnetic resonance imaging of the spine, thoracic laminectomy, and histol ... Full text Link to item Cite

Gait abnormalities and inflammatory cytokines in an autologous nucleus pulposus model of radiculopathy.

Journal Article Spine (Phila Pa 1976) · April 1, 2009 STUDY DESIGN: The authors investigated gait abnormalities and mechanical hypersensitivity associated with invertebral disc herniation in a rat model of radiculopathy. Further evaluation involved assessing how nucleus pulposus (NP) injury affected systemic ... Full text Link to item Cite

fMRI activation mapping as a percentage of local excitation: consistent presurgical motor maps without threshold adjustment.

Journal Article J Magn Reson Imaging · April 2009 PURPOSE: To evaluate the performance of a relative activation amplitude algorithm, versus standard t-value thresholding, for reliably establishing the location, amplitude, and spatial extent of functional magnetic resonance imaging (fMRI) brain activation ... Full text Link to item Cite

Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma.

Journal Article J Clin Oncol · March 10, 2009 PURPOSE: This phase II trial was designed to define the role of O(6)-benzylguanine (O(6)-BG) in restoring temozolomide sensitivity in patients with recurrent or progressive, temozolomide-resistant malignant glioma and to evaluate the safety of administerin ... Full text Link to item Cite

Longitudinal follow up of elevated pulmonary artery pressures in children with sickle cell disease.

Journal Article Br J Haematol · March 2009 Elevated pulmonary artery pressures (PAP) occur in approximately 30% of children with sickle cell disease. In adults, pulmonary hypertension is significantly associated with mortality. There are no data on the long term significance in children. Nineteen c ... Full text Link to item Cite

IDH1 and IDH2 mutations in gliomas.

Journal Article N Engl J Med · February 19, 2009 BACKGROUND: A recent genomewide mutational analysis of glioblastomas (World Health Organization [WHO] grade IV glioma) revealed somatic mutations of the isocitrate dehydrogenase 1 gene (IDH1) in a fraction of such tumors, most frequently in tumors that wer ... Full text Link to item Cite

Introduction: peripheral nerve surgery--biology, entrapment, and injuries.

Journal Article Neurosurg Focus · February 2009 Featured Publication Surgery aimed at repairing damaged peripheral nerves has a long history. Refuting the time-honored nihilism of Hippocrates and Galen that an injured nerve cannot regain function, a few adventurous medieval surgeons attempted to repair severed nerves. Howev ... Full text Link to item Cite

Phase II trial of Gliadel plus O6-benzylguanine in adults with recurrent glioblastoma multiforme.

Journal Article Clin Cancer Res · February 1, 2009 PURPOSE: This phase II trial was designed to define the efficacy of Gliadel wafers in combination with an infusion of O6-benzylguanine (O6-BG) that suppresses tumor O6-alkylguanine-DNA alkyltransferase (AGT) levels in patients with recurrent glioblastoma m ... Full text Link to item Cite

Management of postneurosurgical bone flap loss caused by infection.

Journal Article Plast Reconstr Surg · December 2008 LEARNING OBJECTIVES: After studying this article, the participant should: 1. Be able to define indications and timing for secondary cranioplasty. 2. Understand the surgical options for reconstructing the cranium and overlying soft-tissue defect including t ... Full text Link to item Cite

Anatomy, morphogenesis, diagnosis, management, and outcomes for neonates with common arterial trunk.

Journal Article Cardiol Young · December 2008 Full text Link to item Cite

Microsurgical management of 53 jugular foramen schwannomas: lessons learned incorporated into a modified grading system.

Journal Article J Neurosurg · November 2008 Featured Publication OBJECT: Due to the proximity and involvement of critical neurovascular structures, the resection of jugular foramen schwannomas can pose a formidable challenge. The authors review their experience in the microsurgical management of jugular foramen schwanno ... Full text Link to item Cite

Bevacizumab plus irinotecan in recurrent WHO grade 3 malignant gliomas.

Journal Article Clin Cancer Res · November 1, 2008 Featured Publication PURPOSE: Although patients with newly diagnosed WHO grade 3 malignant glioma have a more favorable prognosis than those with WHO grade 4 malignant glioma, salvage therapies following recurrence offer essentially palliative benefit. We did a phase II trial ... Full text Link to item Cite

Comprehensive genomic characterization defines human glioblastoma genes and core pathways.

Journal Article Nature · October 23, 2008 Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas (TCGA) pilot project aims to assess the value of large-scale multi-dim ... Full text Link to item Cite

Neurophysiological intraoperative monitoring of the glossopharyngeal nerve: technical case report.

Journal Article Neurosurgery · October 2008 OBJECTIVE: Neurophysiological intraoperative monitoring of the glossopharyngeal nerve has been performed only with needle electrodes inserted into the pharyngeal muscles or soft palate. We describe a noninvasive method of monitoring this cranial nerve. MET ... Full text Link to item Cite

Neurophysiological intraoperative monitoring of the glossopharyngeal nerve: Technical case report

Journal Article Neurosurgery · October 1, 2008 OBJECTIVE: Neurophysiological intraoperative monitoring of the glossopharyngeal nerve has been performed only with needle electrodes inserted into the pharyngeal muscles or soft palate. We describe a noninvasive method of monitoring this cranial nerve. MET ... Cite

Synthesis and characterization of a thermally-responsive tumor necrosis factor antagonist.

Journal Article J Control Release · August 7, 2008 Numerous antagonists of tumor necrosis factor alpha (TNFalpha) have been developed to attenuate inflammation and accompanying pain in many disease processes. Soluble TNF receptor type II (sTNFRII) is one such antagonist that sequesters TNFalpha away from t ... Full text Link to item Cite

Cryptococcal meningitis in patients with glioma: a report of two cases.

Journal Article J Neurooncol · August 2008 OBJECTIVE AND IMPORTANCE: We describe two patients with high-grade glioma undergoing treatment with corticosteroids and chemotherapy who presented with cryptococcal meningitis and sepsis. This report of two cases highlights the importance of examining the ... Full text Link to item Cite

Treatment of neuroinflammation by soluble tumor necrosis factor receptor Type II fused to a thermally responsive carrier.

Journal Article J Neurosurg Spine · August 2008 OBJECT: Biochemical irritation of the dorsal root ganglion (DRG) after intervertebral disc herniation contributes to radiculopathy through tumor necrosis factor-alpha (TNFalpha)-mediated inflammation. Soluble TNF receptor Type II (sTNFRII) sequesters this ... Full text Link to item Cite

Mismatch repair deficiency does not mediate clinical resistance to temozolomide in malignant glioma.

Journal Article Clin Cancer Res · August 1, 2008 PURPOSE: A major mechanism of resistance to methylating agents, including temozolomide, is the DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (AGT). Preclinical data indicates that defective DNA mismatch repair (MMR) results in tolerance to temo ... Full text Link to item Cite

Polyethylene glycol hydrogel dural sealant may reduce incisional cerebrospinal fluid leak after posterior fossa surgery.

Journal Article Neurosurgery · July 2008 OBJECTIVE: Incisional cerebrospinal fluid (CSF) leak remains a significant cause of morbidity, particularly after posterior fossa surgery, with ranges between 4 and 17% in most series. We aimed to determine whether the use of a new polyethylene glycol (PEG ... Full text Link to item Cite

Safety and accuracy of bedside external ventricular drain placement: Commentary

Journal Article Neurosurgery · July 1, 2008 Full text Cite

Morphometric three-dimensional computed tomography anatomy of the hypoglossal canal.

Journal Article Neurosurg Rev · July 2008 Optimal surgical exposure during the transcondylar approach may result in injury to the hypoglossal nerve. This study evaluated the utility of three-dimensional computed tomography (3-D CT) as a means of obtaining detailed anatomic information in an indivi ... Full text Link to item Cite

Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors.

Journal Article Neuro Oncol · June 2008 Featured Publication The purpose of this study is to determine the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), and intracerebral distribution of a recombinant toxin (TP-38) targeting the epidermal growth factor receptor in patients with recurrent malignant brai ... Full text Link to item Cite

Safety and pharmacokinetics of dose-intensive imatinib mesylate plus temozolomide: phase 1 trial in adults with malignant glioma.

Journal Article Neuro Oncol · June 2008 We determined the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of imatinib mesylate, an inhibitor of the receptor tyrosine kinases platelet-derived growth factor receptor (PDGFR), the proto-oncogene product c-kit, and the fusion protein Bc ... Full text Link to item Cite

The history of neurosurgery at emory University in Atlanta, Georgia: Commentary

Journal Article Neurosurgery · June 1, 2008 Full text Cite

Immunotherapy against angiogenesis-associated targets: evidence and implications for the treatment of malignant glioma.

Journal Article Expert Rev Anticancer Ther · May 2008 Angiogenesis, the growth of new blood vessels from previously existing vasculature, is a requirement for tumor growth and metastasis. The first US FDA-approved drugs targeting angiogenesis have shown potential in the treatment of malignant gliomas. Immunot ... Full text Link to item Cite

Prenatal course of isolated muscular ventricular septal defects diagnosed only by color Doppler sonography: single-institution experience.

Journal Article J Ultrasound Med · May 2008 OBJECTIVE: Counseling patients with an isolated ventricular septal defect (i-VSD) is clinically important because with high-resolution ultrasound equipment, more small muscular VSDs are now being diagnosed. The prevalence of these lesions is not yet comple ... Full text Link to item Cite

Central nervous system cancers.

Journal Article J Natl Compr Canc Netw · May 2008 Full text Link to item Cite

Comments

Journal Article Neurosurgery · May 1, 2008 Full text Cite

Prevalence and risk factors of elevated pulmonary artery pressures in children with sickle cell disease.

Journal Article Pediatrics · April 2008 OBJECTIVES: The objectives of this study were (1) to determine the prevalence and risk factors of elevated pulmonary artery pressures in children with homozygous SS or Sbeta(0) thalassemia using Doppler echocardiography and (2) to determine a correlation b ... Full text Link to item Cite

An injectable and in situ-gelling biopolymer for sustained drug release following perineural administration.

Journal Article Spine (Phila Pa 1976) · April 1, 2008 STUDY DESIGN: This study evaluated whether the aggregation behavior of a thermally responsive elastin-like polypeptide (ELP) prolongs protein residence time at the dorsal root ganglion (DRG). This work involves development of a sustained-release drug deliv ... Full text Link to item Cite

Molecular strategies for the treatment of malignant glioma--genes, viruses, and vaccines.

Journal Article Neurosurg Rev · April 2008 The standard treatment paradigm of surgery, radiation, and chemotherapy for malignant gliomas has only a modest effect on survival. It is well emphasized in the literature that despite aggressive multimodal therapy, most patients survive approximately 1 ye ... Full text Link to item Cite

A pilot study: 131I-antitenascin monoclonal antibody 81c6 to deliver a 44-Gy resection cavity boost.

Journal Article Neuro Oncol · April 2008 The purpose of this study was to determine the feasibility and assess the efficacy and toxicity, among newly diagnosed malignant glioma patients, of administering (131)I-labeled murine antitenascin monoclonal antibody 81C6 ((131)I-81C6) into a surgically c ... Full text Link to item Cite

Identification of distinct and overlapping cortical areas for bilingual naming and reading using cortical stimulation. Case report.

Journal Article J Neurosurg Pediatr · March 2008 A bilingual pediatric patient who underwent tumor resection was mapped extraoperatively using cortical stimulation to preserve English and Hebrew languages. The authors mapped both languages by using 4 tasks: 1) English visual naming, 2) Hebrew visual nami ... Full text Link to item Cite

Extent of resection and survival in glioblastoma multiforme: Identification of and adjustment for bias - Commentary

Journal Article Neurosurgery · March 1, 2008 Full text Cite

Sensitive detection of human cytomegalovirus in tumors and peripheral blood of patients diagnosed with glioblastoma.

Journal Article Neuro Oncol · February 2008 Human cytomegalovirus (HCMV) has been described to be associated with several human malignancies, though the frequency of detection remains controversial. It is unclear whether HCMV plays an active role in malignant tumor progression or becomes reactivated ... Full text Link to item Cite

Infectious complications of temporary spinal catheter insertion for diagnosis of adult hydrocephalus and idiopathic intracranial hypertension: Commentary

Journal Article Neurosurgery · February 1, 2008 Full text Cite

Clinical experience with alpha-particle emitting 211At: treatment of recurrent brain tumor patients with 211At-labeled chimeric antitenascin monoclonal antibody 81C6.

Journal Article J Nucl Med · January 2008 UNLABELLED: alpha-Particle-emitting radionuclides, such as (211)At, with a 7.2-h half-life, may be optimally suited for the molecularly targeted radiotherapy of strategically sensitive tumor sites, such as those in the central nervous system. Because of th ... Full text Link to item Cite

Challenges and opportunities for recruiting a new generation of neurosurgeons.

Journal Article Neurosurgery · December 2007 Several factors have converged to raise concern among program directors about attracting and training the next generation of neurosurgeons. These include the relatively new duty-hour regulations, the projected physician shortage, and the preference of many ... Full text Link to item Cite

Prevalence of congenital heart defects in monochorionic/diamniotic twin gestations: a systematic literature review.

Journal Article J Ultrasound Med · November 2007 OBJECTIVE: Congenital heart defects (CHDs) affect approximately 0.5% of all neonates. Recent literature points to a possible increase in the CHD prevalence among monochorionic/diamniotic (MC/DA) twin gestations. We hypothesized that MC/DA twin pregnancy is ... Full text Link to item Cite

Bevacizumab plus irinotecan in recurrent glioblastoma multiforme.

Journal Article J Clin Oncol · October 20, 2007 PURPOSE: The prognosis for patients with recurrent glioblastoma multiforme is poor, with a median survival of 3 to 6 months. We performed a phase II trial of bevacizumab, a monoclonal antibody to vascular endothelial growth factor, in combination with irin ... Full text Link to item Cite

Angiotensin converting enzyme inhibition for arterial hypertension reduces the risk of recurrence in patients with chronic subdural hematoma possibly by an antiangiogenic mechanism: Commentary

Journal Article Neurosurgery · October 1, 2007 Full text Cite

Identification, imaging, functional assessment and management of congenital coronary arterial abnormalities in children

Journal Article Cardiology in the Young · September 1, 2007 The coronary arteries, the vessels through which both substrate and oxygen are provided to the cardiac muscle, normally arise from paired stems, right and left, each arising from a separate and distinct sinus of the aortic valve. The right coronary artery ... Full text Cite

Identification, imaging, functional assessment and management of congenital coronary arterial abnormalities in children.

Journal Article Cardiol Young · September 2007 The coronary arteries, the vessels through which both substrate and oxygen are provided to the cardiac muscle, normally arise from paired stems, right and left, each arising from a separate and distinct sinus of the aortic valve. The right coronary artery ... Full text Link to item Cite

Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusions.

Journal Article Neuro Oncol · July 2007 Convection-enhanced delivery (CED) is a novel drug delivery technique that uses positive infusion pressure to deliver therapeutic agents directly into the interstitial spaces of the brain. Despite the promise of CED, clinical trials have demonstrated that ... Full text Link to item Cite

A brief history of surgery for peripheral nerve sheath tumors.

Journal Article Neurosurg Focus · June 15, 2007 The authors present a brief and selective history of surgery for peripheral nerve tumors to illustrate how the current understanding of the nature of disease influences the choice of surgical intervention. There was very little understanding of the anatomy ... Full text Link to item Cite

Tumor resection cavity administered iodine-131-labeled antitenascin 81C6 radioimmunotherapy in patients with malignant glioma: neuropathology aspects.

Journal Article Nucl Med Biol · May 2007 INTRODUCTION: The neurohistological findings in patients treated with targeted beta emitters such as (131)I are poorly described. We report a histopathologic analysis from patients treated with combined external beam therapy and a brachytherapy consisting ... Full text Link to item Cite

Phase II study of imatinib mesylate and hydroxyurea for recurrent grade III malignant gliomas.

Journal Article J Neurooncol · May 2007 PURPOSE: Recent reports demonstrate the activity of imatinib mesylate, an ATP-mimetic, tyrosine kinase inhibitor, plus hydroxyurea, a ribonucleotide reductase inhibitor, in patients with recurrent glioblastoma multiforme. We performed the current phase 2 s ... Full text Link to item Cite

Temozolomide in children with progressive low-grade glioma.

Journal Article Neuro Oncol · April 2007 We conducted a phase II study to assess the efficacy of oral temozolomide (TMZ) in children with progressive low-grade glioma. Thirty eligible patients were enrolled on this study. Median age at enrollment was 10 years (range, 4-18 years). Eligible patient ... Full text Link to item Cite

Wound complications associated with the use of bovine serum albumin-glutaraldehyde surgical adhesive in pediatric patients: Commentary

Journal Article Neurosurgery · April 1, 2007 Full text Cite

Free flap reconstruction of the scalp and calvaria of major neurosurgical resections in cancer patients: lessons learned closing large, difficult wounds of the dura and skull.

Journal Article Plast Reconstr Surg · March 2007 BACKGROUND: Reconstruction of major neurosurgical resections can present a significant challenge because of the morbidity of radiation therapy, cerebrospinal fluid leaks, bacterial contamination from sinus exposure, and functional and cosmetic deformity fr ... Full text Link to item Cite

Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma.

Journal Article Clin Cancer Res · February 15, 2007 PURPOSE: Recurrent grade III-IV gliomas have a dismal prognosis with minimal improvements in survival seen following currently available salvage therapy. This study was conducted to determine if the combination of a novel antiangiogenic therapy, bevacizuma ... Full text Link to item Cite

Intracerebral infusate distribution by convection-enhanced delivery in humans with malignant gliomas: descriptive effects of target anatomy and catheter positioning.

Journal Article Neurosurgery · February 2007 OBJECTIVE: Convection-enhanced delivery (CED) holds tremendous potential for drug delivery to the brain. However, little is known about the volume of distribution achieved within human brain tissue or how target anatomy and catheter positioning influence d ... Full text Link to item Cite

Indications for heart transplantation in pediatric heart disease: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young; the Councils on Clinical Cardiology, Cardiovascular Nursing, and Cardiovascular Surgery and Anesthesia; and the Quality of Care and Outcomes Research Interdisciplinary Working Group.

Journal Article Circulation · February 2007 BACKGROUND: Since the initial utilization of heart transplantation as therapy for end-stage pediatric heart disease, improvements have occurred in outcomes with heart transplantation and surgical therapies for congenital heart disease along with the applic ... Full text Cite

Free flap transfer for the treatment of intractable postcraniotomy subdural empyemas and epidural abscesses: Commentary

Journal Article Neurosurgery · February 1, 2007 Full text Cite

In vivo imaging in a murine model of glioblastoma - Commentary

Journal Article Neurosurgery · February 1, 2007 Full text Cite

Immunohistochemical and electron microscopic studies of langerhans' cell histiocytosis (eosinophilic granuloma) of the orbit

Journal Article Clinical and Refractive Optometry · January 1, 2007 Immunophenotypic and histochemical studies have shown that Langerhans' cell histiocytosis results from an abnormal proliferation of dendritic cells. Characterized by a cytoplasm containing Birbeck granules and S-100 protein, these cells elaborate the surfa ... Cite

Cerebellopontine angle craniopharyngioma: case report and literature review.

Journal Article Pediatr Neurosurg · 2007 The authors report an unusual case of adamantinomatous craniopharyngioma occurring in isolation in the cerebellopontine angle of a 12-year-old female. The patient presented with a 1-year history of nausea, vomiting, and headache. MRI revealed a left cerebe ... Full text Link to item Cite

Phase II study of Cloretazine for the treatment of adults with recurrent glioblastoma multiforme.

Journal Article Neuro Oncol · January 2007 Cloretazine (VNP40101M) is a newly synthesized alkylating agent belonging to a novel class of alkylating agents called 1,2-bis(sulfonyl)hydrazines. Agents that belong to this class do not produce vinylating and chloroethylating species, and hence this clas ... Full text Link to item Cite

Peer discussion

Journal Article Transactions of the American Ophthalmological Society · December 1, 2006 Cite

Immunohistochemical and electron microscopic studies of Langerhans' cell histiocytosis (eosinophilic granuloma) of the orbit

Journal Article Clinical and Surgical Ophthalmology · December 1, 2006 Immunophenotypic and histochemical studies have shown that Langerhans' cell histiocytosis results from an abnormal proliferation of dendritic cells. Characterized by a cytoplasm containing Birbeck granules and S-100 protein, these cells elaborate the surfa ... Cite

Peer discussion

Journal Article Transactions of the American Ophthalmological Society · December 1, 2006 Cite

Primary malignant melanoma of the cerebellopontine angle: A diagnostic dilemma: Case report - Commentary

Journal Article Neurosurgery · December 1, 2006 Full text Cite

Jugular tubercle: Morphometric analysis and surgical significance.

Journal Article J Neurosurg · November 2006 OBJECT: Maximizing intradural exposure via the extreme lateral infrajugular transcondylar-transtubercular exposure (ELITE) approach depends on understanding the fundamental anatomy of the jugular tubercle (JT). Drilling the JT can maximize the extent of ex ... Full text Link to item Cite

Primary spinal intramedullary adrenal cortical adenoma associated with spinal dysraphism: case report.

Journal Article Neurosurgery · November 2006 OBJECTIVE: The authors report a primary spinal intramedullary adrenal cortical adenoma in a patient with spinal dysraphism presenting with bilateral leg pain and urinary frequency. METHODS: Magnetic resonance imaging, L2 laminectomy with resection of mass, ... Full text Link to item Cite

Risk of cerebral vasopasm after subarachnoid hemorrhage reduced by statin therapy: A multivariate analysis of an institutional experience.

Journal Article J Neurosurg · November 2006 OBJECT: Impairment of endothelial nitric oxide synthase (eNOS), endothelium-dependent relaxation, and cerebrovascular autoregulation all occur in vasospastic cerebral arteries following subarachnoid hemorrhage (SAH). The 3-hydroxy-3-methylglutaryl coenzyme ... Full text Link to item Cite

Photodynamic treatment in a rabbit model of glaucoma surgery.

Journal Article Acta Ophthalmol Scand · October 2006 PURPOSE: To evaluate the safety and efficacy of postoperative verteporfin photodynamic treatment as an adjunct to glaucoma experimental filtration surgery in rabbits. METHODS: Dutch belted (n = 15) rabbits underwent full thickness sclerectomy in one eye. T ... Full text Link to item Cite

Quantitative analysis of O6-alkylguanine-DNA alkyltransferase in malignant glioma.

Journal Article Mol Cancer Ther · October 2006 Promoter hypermethylation of the DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (AGT) has been associated with an enhanced response to chloroethylating and methylating agents in patients with malignant glioma. The purpose of this study was to co ... Full text Link to item Cite

Preoperative functional MR imaging localization of language and motor areas: effect on therapeutic decision making in patients with potentially resectable brain tumors.

Journal Article Radiology · September 2006 PURPOSE: To prospectively evaluate the effect of preoperative functional magnetic resonance (MR) imaging localization of language and motor areas on therapeutic decision making in patients with potentially resectable brain tumors. MATERIALS AND METHODS: Th ... Full text Link to item Cite

Three-dimensional computed tomographic analysis of the relationship between the arcuate eminence and the superior semicircular canal.

Journal Article Neurosurgery · July 2006 OBJECTIVE: The location of the superior semicircular canal (SSC) is often determined intraoperatively based on its topographic association with the arcuate eminence (AE). This determination is not always possible because of the potential variability in the ... Full text Link to item Cite

Patient outcomes after vestibular schwannoma management: A prospective comparison of microsurgical resection and stereotactic radiosurgery - Commentary

Journal Article Neurosurgery · July 1, 2006 Full text Cite

Novel human IgG2b/murine chimeric antitenascin monoclonal antibody construct radiolabeled with 131I and administered into the surgically created resection cavity of patients with malignant glioma: phase I trial results.

Journal Article J Nucl Med · June 2006 UNLABELLED: Results from animal experiments have shown that human IgG2/mouse chimeric antitenascin 81C6 (ch81C6) monoclonal antibody exhibited higher tumor accumulation and enhanced stability compared with its murine parent. Our objective was to determine ... Link to item Cite

Multisession CyberKnife radiosurgery for intramedullary spinal cord arteriovenous malformations.

Journal Article Neurosurgery · June 2006 OBJECTIVE: Intramedullary spinal cord arteriovenous malformations (AVMs) have an unfavorable natural history that characteristically involves myelopathy secondary to progressive ischemia and/or recurrent hemorrhage. Although some lesions can be managed suc ... Full text Link to item Cite

Delayed posttraumatic acute subdural hematoma in elderly patients on anticoagulation: Commentary

Journal Article Neurosurgery · May 1, 2006 Full text Cite

Comparison of intratumoral bolus injection and convection-enhanced delivery of radiolabeled antitenascin monoclonal antibodies.

Journal Article Neurosurg Focus · April 15, 2006 Featured Publication OBJECTIVES: Convection-enhanced delivery (CED) is a novel technique used to deliver agents to the brain parenchyma for treatment of neoplastic, infectious, and degenerative conditions. The purpose of this study was to determine if CED would provide a large ... Full text Link to item Cite

Incidence and patterns of neuraxis metastases in children with diffuse pontine glioma.

Journal Article J Neurooncol · April 2006 PURPOSE: We performed a retrospective study of patients with diffuse pontine glioma (DPG) who suffered neuraxis metastasis (NM) and characterized the incidence, clinical features, radiologic findings, and patterns of disease dissemination. METHODS: Magneti ... Full text Link to item Cite

Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma.

Journal Article Cancer Res · March 15, 2006 Immunosuppression is frequently associated with malignancy and is particularly severe in patients with malignant glioma. Anergy and counterproductive shifts toward T(H)2 cytokine production are long-recognized T-cell defects in these patients whose etiolog ... Full text Link to item Cite

Primary myxoma of the parafalcine meninges. Case report.

Journal Article J Neurosurg · March 2006 The authors report on an unusual case of a primary intracranial myxoma in a 39-year-old woman. The patient presented with headache and generalized seizure. Magnetic resonance imaging revealed a large right frontal tumor resembling a parasagittal meningioma ... Full text Link to item Cite

Trends in fetal echocardiography and implications for clinical practice: 1985 to 2003.

Journal Article J Ultrasound Med · February 2006 OBJECTIVE: The purpose of this study was to determine whether patterns of referral for fetal echocardiography (FE) and the subsequent yield for structural congenital heart disease (CHD) have changed between 1985 and 2003. METHODS: All FE performed between ... Full text Link to item Cite

Phase 1 trial of gefitinib plus sirolimus in adults with recurrent malignant glioma.

Journal Article Clin Cancer Res · February 1, 2006 PURPOSE: To determine the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of gefitinib, a receptor tyrosine kinase inhibitor of the epidermal growth factor receptor, plus sirolimus, an inhibitor of the mammalian target of rapamycin, among pat ... Full text Link to item Cite

Cranioplasty after trephination using a novel biodegradable burr hole cover: Technical case report - Commentary

Journal Article Neurosurgery · February 1, 2006 Cite

FLAIR-/T1-/T2-co-registration for image-guided diagnostic and resective epilepsy surgery: Commentary

Journal Article Neurosurgery · February 1, 2006 Cite

Astrocytoma of the spinal cord

Chapter · January 1, 2006 Full text Cite

Diffuse astrocytoma

Chapter · January 1, 2006 Full text Cite

Anaplastic astrocytoma

Chapter · January 1, 2006 Cite

Astrocytoma of the brainstem

Chapter · January 1, 2006 Full text Cite

Pleomorphic xanthoastrocytoma

Chapter · January 1, 2006 Cite

Glioblastoma

Chapter · January 1, 2006 Cite

Salvage radioimmunotherapy with murine iodine-131-labeled antitenascin monoclonal antibody 81C6 for patients with recurrent primary and metastatic malignant brain tumors: phase II study results.

Journal Article J Clin Oncol · January 1, 2006 PURPOSE: To assess the efficacy and toxicity of intraresection cavity iodine-131-labeled murine antitenascin monoclonal antibody 81C6 (131I-m81C6) among recurrent malignant brain tumor patients. PATIENTS AND METHODS: In this phase II trial, 100 mCi of 131I ... Full text Link to item Cite

Potential additional indicators for pacemaker requirement in isolated congenital atrioventricular block.

Journal Article Pediatr Cardiol · 2006 Low heart rate is the predominantly used indication for pacemaker intervention in patients with isolated congenital atrioventricular block (CAVB). The aim of this study was to compare the difference in heart rates recorded with ECG and Holter monitoring be ... Full text Link to item Cite

Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme.

Journal Article J Clin Oncol · December 20, 2005 PURPOSE: We performed a phase II study to evaluate the combination of imatinib mesylate, an adenosine triphosphate mimetic, tyrosine kinase inhibitor, plus hydroxyurea, a ribonucleotide reductase inhibitor, in patients with recurrent glioblastoma multiform ... Full text Link to item Cite

Brain metastases from malignant melanoma

Journal Article · December 1, 2005 Full text Cite

Ependymoma

Journal Article · December 1, 2005 Full text Cite

Survival analysis of presumptive prognostic markers among oligodendrogliomas.

Journal Article Cancer · October 15, 2005 BACKGROUND: Allelic losses of 1p and 19q arms correlate with the oligodendroglial phenotype as well as with sensitivity to radiotherapy and chemotherapy. Furthermore, the DNA repair gene, methylguanine methyltransferase (MGMT), is diminished in 80% of olig ... Full text Link to item Cite

Movement-attention coupling in infancy and attention problems in childhood.

Journal Article Dev Med Child Neurol · October 2005 Adaptive behavior requires the integration of body movement and attention. Therefore, individual differences in integration of movement and attention during infancy may have significance for development. We contacted families whose 8-year-old children (n=2 ... Full text Link to item Cite

Phase I trial of irinotecan plus temozolomide in adults with recurrent malignant glioma.

Journal Article Cancer · October 1, 2005 BACKGROUND: The authors determined the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of irinotecan (CPT-11), a topoisomerase I inhibitor, when administered with temozolomide among patients with recurrent malignant glioma (MG). METHODS: Pati ... Full text Link to item Cite

Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.

Journal Article J Clin Oncol · October 1, 2005 PURPOSE: We conducted a two-phase clinical trial in patients with progressive malignant glioma (MG). The first phase of this trial was designed to determine the dose of O6-BG effective in producing complete depletion of tumor AGT activity for 48 hours. The ... Full text Link to item Cite

Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trial.

Journal Article Stroke · September 2005 BACKGROUND AND PURPOSE: Cerebral vasospasm remains a major source of morbidity after aneurysmal subarachnoid hemorrhage (SAH). We demonstrate that simvastatin reduces serum markers of brain injury and attenuates vasospasm after SAH. METHODS: Patients with ... Full text Link to item Cite

Chemotherapy and novel therapeutic approaches in malignant glioma.

Journal Article Front Biosci · September 1, 2005 Glial neoplasms represent 0.5-1% of all cancers in most Western countries. Malignant gliomas are among the most devastating cancers, leading to death in most cases. They present unique challenges due to their location, aggressive biological behavior and di ... Full text Link to item Cite

Central nervous system cancers: Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · September 2005 Full text Link to item Cite

External rotation as a result of suprascapular nerve neurotization in obstetric brachial plexus lesions: Comments

Journal Article Neurosurgery · September 1, 2005 Cite

Myxopapillary Ependymoma and Fatty Filum in an Adult with Tethered Cord Syndrome: A Shared Embryological Lesion? Case Report.

Journal Article Neurosurgery · August 1, 2005 Full text Link to item Cite

871 Simvastatin Reduces Vasospasm after Aneurysmal Subarachnoid Hemorrhage: Results of a Pilot Randomized Clinical Trial.

Journal Article Neurosurgery · August 1, 2005 Full text Link to item Cite

A retrospective analysis of a remifentanil/propofol general anesthetic for craniotomy before awake functional brain mapping.

Journal Article Anesth Analg · August 2005 UNLABELLED: We performed this study to summarize drug dosing, physiologic responses, and anesthetic complications from an IV general anesthetic technique for patients undergoing craniotomy for awake functional brain mapping. Review of 98 procedures reveale ... Full text Link to item Cite

Management and outcomes of 42 surgical suprascapular nerve injuries and entrapments: Comments

Journal Article Neurosurgery · July 1, 2005 Cite

Dosimetry and radiographic analysis of 131I-labeled anti-tenascin 81C6 murine monoclonal antibody in newly diagnosed patients with malignant gliomas: a phase II study.

Journal Article J Nucl Med · June 2005 UNLABELLED: The objective was to perform dosimetry and evaluate dose-response relationships in newly diagnosed patients with malignant brain tumors treated with direct injections of (131)I-labeled anti-tenascin murine 81C6 monoclonal antibody (mAb) into su ... Link to item Cite

Surgical management of petroclival meningiomas: defining resection goals based on risk of neurological morbidity and tumor recurrence rates in 137 patients.

Journal Article Neurosurgery · March 2005 Featured Publication OBJECTIVE: Meningiomas arising from the petroclival region remain a challenging surgical problem. Because of the substantial risk of neurological morbidity, uniformly pursuing a gross total resection (GTR) to minimize tumor recurrence rates may not be just ... Full text Link to item Cite

Surgical management of 10 genitofemoral neuralgias at the Louisiana State University Health Sciences Center - Comments

Journal Article Neurosurgery · February 1, 2005 Cite

Phase II trial of irinotecan plus celecoxib in adults with recurrent malignant glioma.

Journal Article Cancer · January 15, 2005 BACKGROUND: In the current study, the authors report a Phase II trial of irinotecan (CPT-11), a topoisomerase I inhibitor active against malignant glioma (MG), with celecoxib, a selective COX-2 inhibitor, among MG patients with recurrent disease. METHODS: ... Full text Link to item Cite

Surgical exposure of the sciatic nerve in the gluteal region: anatomic and historical comparison of two approaches.

Journal Article Neurosurgery · January 2005 Featured Publication OBJECTIVE: To increase awareness among neurosurgeons of alternative surgical approaches to lesions of the sciatic nerve in the gluteal region. METHODS: The dominant surgical approach to lesions of the proximal sciatic nerve involves detachment and medial r ... Full text Link to item Cite

Sustained radiographic and clinical response in patient with bifrontal recurrent glioblastoma multiforme with intracerebral infusion of the recombinant targeted toxin TP-38: case study.

Journal Article Neuro Oncol · January 2005 Glioblastoma multiforme remains refractory to conventional therapy, and novel therapeutic modalities are desperately needed. TP-38 is a recombinant chimeric protein containing a genetically engineered form of the cytotoxic Pseudomonas exotoxin fused to tra ... Full text Link to item Cite

Xanthogranuloma of the sciatic nerve: case report.

Journal Article Neurosurgery · December 2004 OBJECTIVE AND IMPORTANCE: Xanthogranulomas involving the central or peripheral nervous system are extraordinarily rare. None have been reported in the lower extremity. Here, we report and characterize the first case of xanthogranuloma of the sciatic nerve. ... Link to item Cite

Training pediatric residents to evaluate congenital heart disease in the current era.

Journal Article Pediatr Clin North Am · December 2004 Working with young pediatricians to create an exciting educational environment in which to learn cardiology remains a challenge for all of us. Numerous forces impact our efforts, making the process of training residents to evaluate and treat congenital hea ... Full text Link to item Cite

Acquired subretinal flecks secondary to hypovitaminosis A in a patient with hepatitis C.

Journal Article Doc Ophthalmol · November 2004 Full text Link to item Cite

Correlation of serum brain natriuretic peptide with hyponatremia and delayed ischemic neurological deficits after subarachnoid hemorrhage.

Journal Article Neurosurgery · June 2004 OBJECTIVE: Serum brain natriuretic peptide (BNP) is elevated after subarachnoid hemorrhage (SAH), causes diuresis and natriuresis (cerebral salt wasting), and may exacerbate delayed ischemic neurological deficits. We examined the temporal relationship betw ... Full text Link to item Cite

Resistance to tyrosine kinase inhibition by mutant epidermal growth factor receptor variant III contributes to the neoplastic phenotype of glioblastoma multiforme.

Journal Article Clin Cancer Res · May 1, 2004 PURPOSE: We have reported previously that tumors expressing wild-type epidermal growth factor receptor (EGFR) in a murine model are sensitive to the EGFR tyrosine kinase inhibitor gefitinib, whereas tumors expressing mutant EGFR variant III (EGFRvIII) are ... Full text Link to item Cite

Median nerve excursion during endoscopic carpal tunnel release.

Journal Article Neurosurgery · May 2004 OBJECTIVE: Restriction of the excursion of the nerve has been accepted as a pathogenetic element in carpal tunnel syndrome. The goal of this article was to evaluate the median nerve excursion in the carpal tunnel measured as a function of wrist position be ... Full text Link to item Cite

An eclectic history of peripheral nerve surgery.

Journal Article Neurosurg Clin N Am · April 2004 It is hard to decide where history stops and contemporary development of peripheral nerve surgery begins. This article provides an eclectic view of the history of peripheral nerve surgery. In trying to keep the story moving, the publications of many author ... Full text Link to item Cite

Phase 1 trial of irinotecan plus BCNU in patients with progressive or recurrent malignant glioma.

Journal Article Neuro Oncol · April 2004 Irinotecan is a topoisomerase I inhibitor previously shown to be active in the treatment of malignant glioma. We now report the results of a phase 1 trial of irinotecan plus BCNU, or 1,3-bis(2-chloroethyl)-1-nitrosourea, for patients with recurrent or prog ... Full text Link to item Cite

Phase 2 trial of BCNU plus irinotecan in adults with malignant glioma.

Journal Article Neuro Oncol · April 2004 In preclinical studies, BCNU, or 1,3-bis(2-chloroethyl)-1-nitrosourea, plus CPT-11 (irinotecan) exhibits schedule-dependent, synergistic activity against malignant glioma (MG). We previously established the maximum tolerated dose of CPT-11 when administere ... Full text Link to item Cite

Postherpetic neuralgia

Journal Article Seminars in Neurosurgery · March 1, 2004 Postherpetic neuralgia (PHN) is a chronic neuropathic pain syndrome defined as pain persisting more than 3 months after the resolution of herpes zoster-associated rash. It is often characterized as spontaneous aching or burning with paroxysmal shooting pai ... Full text Cite

Cerebellar malignant fibrous histiocytoma: case report and literature review.

Journal Article Neurosurgery · March 2004 OBJECTIVE AND IMPORTANCE: Malignant fibrous histiocytoma in the central nervous system is uncommon. Fewer than 70 cases have been documented and, to the best of our knowledge, this is the first case arising from the cerebellum. CLINICAL PRESENTATION: A 44- ... Full text Link to item Cite

Awake craniotomy for malignant glioma resection

Journal Article International Congress Series · February 1, 2004 There is mounting evidence that gross total resection (GTR) of the MRI contrast-enhancing portions of malignant gliomas (WHO grades III and IV) improves survival. Any survival benefits gained from the aggressive resection of high-grade gliomas suspected of ... Full text Cite

Vitrectomy for epiretinal membranes with good visual acuity.

Journal Article Trans Am Ophthalmol Soc · 2004 PURPOSE: To evaluate the visual results of vitrectomy for epiretinal membrane in eyes with a preoperative visual acuity of 20/50 or better. METHODS: The visual results and complications were analyzed following vitrectomy for idiopathic epiretinal membranes ... Link to item Cite

Presumed sinus-related strabismus.

Journal Article Trans Am Ophthalmol Soc · 2004 PURPOSE: To determine whether sinus disease may cause acquired strabismus. METHODS: Patients with idiopathic acquired (nonaccommodative) esotropia and/or hypotropia were questioned in detail about possible contributing factors (trauma; family history of st ... Link to item Cite

Phase II trial of gefitinib in recurrent glioblastoma.

Journal Article J Clin Oncol · January 1, 2004 PURPOSE: To evaluate the efficacy and tolerability of gefitinib (ZD1839, Iressa; AstraZeneca, Wilmington, DE), a novel epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. PATIENTS AND METHODS: This was an op ... Full text Link to item Cite

Malignant peripheral nerve sheath tumor of the spine after radiation therapy for Hodgkin's lymphoma.

Journal Article Clin Neuropathol · 2004 We report the development of a malignant peripheral nerve sheath tumor (MPNST) in 2 patients after irradiation for Hodgkin's lymphoma. Clinicians should be aware of this uncommon, but important fatal complication of radiation therapy. The first case is a 3 ... Link to item Cite

Predictors of outcome of myocarditis.

Journal Article Pediatr Cardiol · 2004 Heart failure from myocarditis may be transient or may progress to unremitting severe cardiac failure. This study was performed to determine the outcomes and prognostic features of pediatric patients with myocarditis. Patients with the diagnosis of myocard ... Full text Link to item Cite

Intraventricular solitary fibrous tumor: an unusual tumor with radiological, ultrastructural, and immunohistochemical evaluation: case report.

Journal Article Neurosurgery · January 2004 OBJECTIVE AND IMPORTANCE: Intracranial solitary fibrous tumors have been described previously, but intraventricular solitary fibrous tumors are extremely rare. We present what is, to our knowledge, the first reported case of solitary fibrous tumor in the t ... Full text Link to item Cite

Efficacy of intracerebral microinfusion of trastuzumab in an athymic rat model of intracerebral metastatic breast cancer.

Journal Article Clin Cancer Res · November 15, 2003 PURPOSE: The monoclonal antibody (MAb) trastuzumab (Herceptin) effectively treats HER2-overexpressing extracerebral breast neoplasms. Delivery of such macromolecule therapeutic agents to intracerebral metastases, however, is limited by the tight junctions ... Link to item Cite

Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malignant brain tumors.

Journal Article J Neurooncol · October 2003 TP-38 is a recombinant chimeric targeted toxin composed of the EGFR binding ligand TGF-alpha and a genetically engineered form of the Pseudomonas exotoxin, PE-38. After in vitro and in vivo animal studies that showed specific activity and defined the maxim ... Full text Link to item Cite

Rate of resolution of histologically verified intracranial tuberculomas.

Journal Article Neurosurgery · October 2003 OBJECTIVE: The goal of this study was to determine the rate of radiological resolution of histopathologically proven tuberculomas treated with antituberculous therapy (ATT). The effects of the size of the tuberculomas, the number of tuberculomas, and the a ... Full text Link to item Cite

Epidermal growth factor receptor VIII peptide vaccination is efficacious against established intracerebral tumors.

Journal Article Clin Cancer Res · September 15, 2003 PURPOSE: The epidermal growth factor receptor (EGFR) is often amplified and structurally rearranged in malignant gliomas and other tumors such as breast and lung, with the most common mutation being EGFRvIII. In the study described here, we tested in mouse ... Link to item Cite

Congenitally absent C-7 pedicle presenting as a jumped locked facet. Case illustration.

Journal Article J Neurosurg · September 2003 Full text Link to item Cite

High-dose chemotherapy with autologous stem-cell rescue in children and adults with newly diagnosed pineoblastomas.

Journal Article J Clin Oncol · June 1, 2003 PURPOSE: We evaluated the usefulness of a treatment regimen that included high-dose chemotherapy (HDC) with autologous stem-cell rescue (ASCR) in patients with newly diagnosed pineoblastoma (PBL). PATIENTS AND METHODS: Twelve patients with PBL were initial ... Full text Link to item Cite

Leukocytosis as an independent risk factor for cerebral vasospasm following aneurysmal subarachnoid hemorrhage.

Journal Article J Neurosurg · June 2003 OBJECT: The identification of patients at an increased risk for cerebral vasospasm after subarachnoid hemorrhage (SAH) may allow for more aggressive treatment and improved patient outcomes. Note, however, that blood clot size on admission remains the only ... Full text Link to item Cite

Preoperative evaluation of neural tracts by use of three-dimensional anisotropy contrast imaging in a patient with brainstem cavernous angioma: technical case report.

Journal Article Neurosurgery · May 2003 OBJECTIVE AND IMPORTANCE: We describe a case of brainstem cavernous angioma in which the neural tracts were evaluated before surgery by three-dimensional anisotropy contrast (3-DAC) magnetic resonance imaging. CLINICAL PRESENTATION: A 64-year-old man prese ... Link to item Cite

MRI-guided stereotactic biopsy in the diagnosis of glioma: comparison of biopsy and surgical resection specimen.

Journal Article Surg Neurol · April 2003 BACKGROUND: Although there has been a dramatic increase in the accessibility and utilization of high-resolution MRI techniques for the evaluation of brain tumors, there is currently only a single report comparing stereotactic brain biopsy specimen to subse ... Full text Link to item Cite

Use of the peak troponin value to differentiate myocardial infarction from reversible neurogenic left ventricular dysfunction associated with aneurysmal subarachnoid hemorrhage.

Journal Article J Neurosurg · March 2003 OBJECT: Differentiating myocardial infarction (MI) from reversible neurogenic left ventricular dysfunction (stunned myocardium [SM]) associated with aneurysmal subarachnoid hemorrhage (SAH) is critical for early surgical intervention. The authors hypothesi ... Full text Link to item Cite

Phase II trial of temozolomide in patients with progressive low-grade glioma.

Journal Article J Clin Oncol · February 15, 2003 PURPOSE: Temozolomide (Temodar; Schering-Plough Corp, Kenilworth, NJ) is an imidazole tetrazinone that undergoes chemical conversion to the active methylating agent 5-(3-methyltriazen-1yl)imidazole-4-carboximide under physiologic conditions. Previous studi ... Full text Link to item Cite

Spinal muscular atrophy type 1 quality of life.

Journal Article Am J Phys Med Rehabil · February 2003 OBJECTIVE: To compare healthcare professionals' assessment of the quality of life of spinal muscular atrophy type 1 children with that of the care providers for the children. DESIGN: The care providers of all 53 surviving spinal muscular atrophy type 1 chi ... Full text Link to item Cite

The "demise" of diagnostic and research ocular pathology: temporary or forever?

Conference Trans Am Ophthalmol Soc · 2003 PURPOSE: Several authorities have documented a significant decrease in support for modern eye pathology/pathology research laboratories. Indeed, many laboratories have closed or suffered marked cutbacks. The purpose of this report is to ask why this is so ... Link to item Cite

Immunohistochemical and electron microscopic studies of Langerhans' cell histiocytosis (Eosinophilic granuloma) of the orbit

Journal Article Ophthalmic Practice · January 1, 2003 Immunophenotypic and histochemical studies have shown that Langerhans' cell histiocytosis results from an abnormal proliferation of dendritic cells. Characterized by a cytoplasm containing Birbeck granules and S-100 protein, these cells elaborate the surfa ... Cite

Graded full-thickness anterior blepharotomy for upper eyelid retraction.

Conference Trans Am Ophthalmol Soc · 2003 PURPOSE: A chief morbidity of Graves' eye disease (GED) is upper lid retraction that results in exposure keratopathy and cosmetic deformity. This study was conducted to assess the efficacy of graded anterior blepharotomy to treat upper lid retraction. METH ... Link to item Cite

Histopathologic features of trabeculectomy surgery.

Conference Trans Am Ophthalmol Soc · 2003 PURPOSE: Trabeculectomy surgery is the most common operative procedure for the treatment of medically uncontrolled glaucoma. Variability exists in both the design and the position of the limbal wound as well as in outcomes, even in cases with similarly des ... Link to item Cite

Primary orbital angiomatous meningioma.

Journal Article Arch Ophthalmol · January 2003 Full text Link to item Cite

Prognostic value of magnetic resonance imaging-guided stereotactic biopsy in the evaluation of recurrent malignant astrocytoma compared with a lesion due to radiation effect.

Journal Article J Neurosurg · January 2003 OBJECT: The prognostic value of differentiating between recurrent malignant glioma and a lesion due to radiation effect by performing stereotactic biopsy has not been assessed. Thus, this study was undertaken to determine such value. METHODS: Between 1995 ... Full text Link to item Cite

Transient choroid plexus cysts and benign asymmetrical ventricles: a case suggesting a possible link: case report.

Journal Article Neurosurgery · January 2003 OBJECTIVE AND IMPORTANCE: Brain magnetic resonance imaging scans occasionally reveal asymmetrical ventricles with no identifiable cause. A case is presented that highlights a possible connection between transient choroid plexus cysts and benign asymmetrica ... Full text Link to item Cite

Pacemaker therapy in isolated congenital complete atrioventricular block.

Journal Article Pacing Clin Electrophysiol · December 2002 The aim of this study was to evaluate the effect of pacemaker (PM) therapy in patients with isolated congenital complete atrioventricular block (CCAVB). Patients with CCAVB eventually quality for PM implantation, however, timing remains controversial. Retr ... Full text Link to item Cite

Stability of fibrin sealant in cerebrospinal fluid: an in vitro study.

Journal Article Neurosurgery · December 2002 OBJECTIVE: The in vitro stability of fibrin sealant in cerebrospinal fluid (CSF) was investigated to verify the efficacy of intracranial application of fibrin sealant. METHODS: Human CSF was collected from 11 patients. Fibrin glue spheres (diameter, 5 mm) ... Link to item Cite

Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (iressa).

Journal Article Clin Cancer Res · November 2002 Featured Publication Iressa (ZD1839) is a p.o.-active, selective, epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) that blocks signal transduction pathways implicated in cancer cell proliferation, survival, and host-dependent processes promoting cancer gro ... Link to item Cite

Serum von Willebrand factor, matrix metalloproteinase-9, and vascular endothelial growth factor levels predict the onset of cerebral vasospasm after aneurysmal subarachnoid hemorrhage.

Journal Article Neurosurgery · November 2002 Featured Publication OBJECTIVE: Endothelial damage and intimal proliferation occur in vasospastic cerebral arteries after subarachnoid hemorrhage (SAH). In the peripheral vasculature, endothelial damage increases intimal matrix metalloproteinase-9 (MMP-9) and vascular endothel ... Full text Link to item Cite

Necrotizing neurosarcoidosis of the cranial base resembling an en plaque sphenoid wing meningioma: case report.

Journal Article Neurosurgery · November 2002 OBJECTIVE AND IMPORTANCE: Necrotizing sarcoid granuloma (NSG) has been recognized as a histological variant of sarcoidosis. Two cases of neurosarcoidosis (NS) with NSG with concomitant systemic disease have been described previously. We present an unusual ... Full text Link to item Cite

Management of malignant tumors of the anterior skull base: experience with 76 patients.

Journal Article Neurosurg Focus · October 15, 2002 As the management of anterior cranial fossa malignancies has undergone significant evolution, decreases in morbidity and mortality rates have occurred. In this article, the authors discuss the clinical presentation, neuroimaging findings, and management op ... Full text Link to item Cite

Influence of filgrastim (granulocyte colony-stimulating factor) on human immunodeficiency virus type 1 RNA in patients with cytomegalovirus retinitis.

Journal Article J Infect Dis · October 1, 2002 Filgrastim, or granulocyte colony-stimulating factor, reverses neutropenia associated with human immunodeficiency virus type 1 (HIV-1) and cytomegalovirus (CMV) infections. During a trial of anti-CMV retinitis therapies coadministered with antiretroviral t ... Full text Link to item Cite

Endocardial and epicardial steroid lead pacing in the neonatal and paediatric age group.

Journal Article Heart · October 2002 AIM: To compare the performance of steroid eluting epicardial and endocardial leads in infants and children requiring permanent pacing. METHODS: Evaluation of pacing and sensing characteristics, impedances, and longevity of 159 steroid eluting leads implan ... Full text Link to item Cite

Current options for the treatment of neoplastic meningitis.

Journal Article J Neurooncol · October 2002 Featured Publication Neoplastic meningitis, which is the diffuse involvement of the leptomeninges by infiltrating cancer cells, may be caused by many systemic tumors. The treatment options for neoplastic meningitis disease remain unsatisfactory. In this review article, we disc ... Full text Link to item Cite

Endoscopic cranioplasty with calcium phosphate cement for pterional bone defect after frontotemporal craniotomy: technical note.

Journal Article Neurosurgery · October 2002 OBJECTIVE: Postoperative pterional depression is a minor but unpleasant sequela of frontotemporal craniotomy. We developed a simple method for repair of this condition with the use of an endoscope and calcium phosphate cement. METHODS: The cranial defect w ... Full text Link to item Cite

Surgical treatment of nocardial brain abscesses.

Journal Article Neurosurgery · September 2002 OBJECTIVE: Nocardial brain abscesses are associated with significant morbidity and mortality rates. The optimal management remains unclear. We reviewed the surgical outcomes of patients treated with a relatively uniform policy at a single institution. METH ... Link to item Cite

Isolated, giant cerebellopontine angle craniopharyngioma in a patient with Gardner syndrome: case report.

Journal Article Neurosurgery · July 2002 OBJECTIVE AND IMPORTANCE: We report the case of a 29-year-old man with Gardner syndrome and an isolated, giant cerebellopontine angle craniopharyngioma. Our description of this patient is only the second case report of a craniopharyngioma arising primarily ... Full text Link to item Cite

Cerebellar hemorrhage after spinal surgery: report of two cases and literature review.

Journal Article Neurosurgery · June 2002 OBJECTIVE AND IMPORTANCE: Cerebellar hemorrhage remote from the site of surgery may complicate neurosurgical procedures. We describe our experience with two cases of cerebellar hemorrhage after spinal surgery and review the three cases previously reported ... Full text Link to item Cite

Molecular markers of prognosis in astrocytic tumors.

Journal Article Cancer · May 15, 2002 BACKGROUND: Astrocytoma is a primary brain tumor that affects 20,000 Americans each year. To date, only age and histologic grade stand out as independent predictors of survival. There is now increased interest in the use of molecular markers as objective s ... Full text Link to item Cite

Management of tumor bed cysts after chemotherapeutic wafer implantation. Report of four cases.

Journal Article J Neurosurg · May 2002 Adjuvant use of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) wafers with surgical resection is becoming common for the treatment of malignant gliomas. Cyst formation in the tumor resection cavity is a recently described complication associated with the use ... Full text Link to item Cite

Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma.

Journal Article J Clin Oncol · May 1, 2002 PURPOSE: We conducted a phase II trial of carmustine (BCNU) plus the O(6)-alkylguanine-DNA alkyltransferase inhibitor O(6)-benzylguanine (O(6)-BG) to define the activity and toxicity of this regimen in the treatment of adults with progressive or recurrent ... Full text Link to item Cite

Prognostic significance of amino acid transport imaging in patients with brain tumors.

Journal Article Neurosurgery · May 2002 OBJECTIVE: To evaluate the prognostic significance of presence, intensity, and extent of amino acid uptake in patients with suspected primary or recurrent brain tumors. METHODS: We retrospectively analyzed 181 consecutive studies of amino acid uptake using ... Full text Link to item Cite

Diagnosis of cardiac defects: where we've been, where we are and where we're going.

Journal Article Prenat Diagn · April 2002 There has been tremendous development in the field of prenatal diagnosis of cardiac disease in the last 30 years. Early work centered on the technical aspects of providing an accurate assessment of cardiac structure and function. Techniques of fetal cardia ... Full text Link to item Cite

Phase II study of irinotecan (CPT-11) in children with high-risk malignant brain tumors: the Duke experience.

Journal Article Neuro Oncol · April 2002 A phase II study of irinotecan (CPT-11) was conducted at Duke University Medical Center, Durham, NC, to evaluate the activity of this agent in children with high-risk malignant brain tumors. A total of 22 children were enrolled in this study, including 13 ... Full text Link to item Cite

Phase II trial of murine (131)I-labeled antitenascin monoclonal antibody 81C6 administered into surgically created resection cavities of patients with newly diagnosed malignant gliomas.

Journal Article J Clin Oncol · March 1, 2002 PURPOSE: To assess the efficacy and toxicity of intraresection cavity (131)I-labeled murine antitenascin monoclonal antibody 81C6 and determine its true response rate among patients with newly diagnosed malignant glioma. PATIENTS AND METHODS: In this phase ... Full text Link to item Cite

Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes.

Journal Article Genomics · February 2002 Ceramide is an important cellular lipid involved in signal transduction and the biosynthesis of complex sphingolipids. It can be hydrolyzed into sphingosine, another important signaling lipid, by the activity of ceramidases. Point mutations in the gene (As ... Full text Cite

A very large Brazilian pedigree with 11778 Leber's hereditary optic neuropathy.

Conference Trans Am Ophthalmol Soc · 2002 PURPOSE: We conducted extensive epidemiological, neuro-ophthalmological, psychophysical, and blood examinations on a newly discovered, very large pedigree with molecular analysis showing mtDNA mutation for Leber's hereditary optic neuropathy (LHON). METHOD ... Link to item Cite

Dendritic cells pulsed with a tumor-specific peptide induce long-lasting immunity and are effective against murine intracerebral melanoma.

Journal Article Neurosurgery · January 2002 Featured Publication OBJECTIVE: Dendritic cells (DCs) are specialized cells of the immune system that are capable of generating potent immune responses that are active even within the "immunologically privileged" central nervous system. However, immune responses generated by D ... Full text Link to item Cite

Pediatric grand rounds: a tribute to Norman J. Siegel, M.D.

Journal Article Yale J Biol Med · 2002 At ceremonies held in Baltimore Maryland on May, 4, 2002, Dr. Howard A Pearson, Professor of Pediatrics, was awarded the John A. Howland award of the American Pediatric Society, probably the most prestigious award of American Pediatrics. Dr. Pearson had be ... Link to item Cite

Lateralized seizure termination: relationship to outcome following anterior temporal lobectomy.

Journal Article Epilepsy Res · November 2001 Determination of side of seizure onset is critical for a successful outcome following epilepsy surgery. Little is known about the significance of lateralized seizure termination. Sustained seizure activity contralateral to side of seizure onset, following ... Full text Link to item Cite

Intractable epilepsy following radiosurgery for arteriovenous malformation.

Journal Article J Neurosurg · November 2001 Featured Publication Radiosurgery is often used to treat arteriovenous malformations (AVMs) located in deep brain locations. Most of these procedures are successful not only in obliterating the AVM but also in decreasing the frequency and severity of associated seizures. Altho ... Full text Link to item Cite

Phase I study of Gliadel wafers plus temozolomide in adults with recurrent supratentorial high-grade gliomas.

Journal Article Neuro Oncol · October 2001 Both Gliadel wafers [1,3-bis(2-chloroethyl)-1-nitrosourea] and temozolomide (TEMO) have been shown in independent studies to prolong survival of patients with recurrent malignant glioma following surgery and radiotherapy. On the basis of preclinical eviden ... Full text Link to item Cite

Surgical approaches to pineal region tumors.

Journal Article J Neurooncol · September 2001 Featured Publication Direct surgical resection of pineal region tumors has become safer, more effective, and now plays an essential role in their management. Tissue diagnosis allows for the initiation of appropriate therapies and resection can be curative or improve the effica ... Full text Link to item Cite

Clinical Studies in Non-chromosome 4-Linked Facioscapulohumeral Muscular Dystrophy.

Journal Article J Clin Neuromuscul Dis · September 2001 OBJECTIVES: To characterize clinically and molecularly a large, non-chromosome 4-linked facioscapulohumeral muscular dystrophy (FSHMD) family. METHODS: Neurological evaluations of affected (N = 55) and at-risk (N = 48) individuals were performed along with ... Full text Link to item Cite

Three-dimensional computed tomographic cranial base measurements for improvement of surgical approaches to the petrous carotid artery and apex regions.

Journal Article Neurosurgery · August 2001 OBJECTIVE: The bony and vascular anatomic features in the region of the petrous apex can vary significantly. These variations affect the operative view obtained via extended subtemporal or anterior transpetrosal approaches to cranial base lesions for indiv ... Full text Link to item Cite

Ectopic cardiac calcification associated with hyperparathyroidism in a boy with hypophosphatemic rickets.

Journal Article Curr Opin Pediatr · August 2001 An adolescent with hypophosphatemic rickets developed cardiac calcifications in the absence of hypercalcemia or elevation of the phosphocalcic product (the product of the total serum calcium and phosphorus concentrations). Cardiac calcifications led to aor ... Full text Link to item Cite

Safety of perioperative minidose heparin in patients undergoing brain tumor surgery: a prospective, randomized, double-blind study.

Journal Article J Neurosurg · June 2001 OBJECT: Thromboembolic phenomena (TEPs) continue to be a significant source of morbidity and mortality in patients undergoing neurosurgery. Although the efficacy of low-dose heparin in preventing TEPs in neurosurgical patients is well established, neurosur ... Full text Link to item Cite

Long term response in a patient with neoplastic meningitis secondary to melanoma treated with (131)I-radiolabeled antichondroitin proteoglycan sulfate Mel-14 F(ab')(2): a case study.

Journal Article Cancer · May 1, 2001 Even with novel chemotherapeutic agents and external beam radiation therapy, the prognosis of neoplastic meningitis secondary to malignant melanoma is still dismal. The authors report a case study of a 46-year-old white female who presented with progressiv ... Link to item Cite

Dilated cardiomyopathy in isolated congenital complete atrioventricular block: early and long-term risk in children.

Journal Article J Am Coll Cardiol · March 15, 2001 OBJECTIVES: We sought to identify the risk factors predicting the development of dilated cardiomyopathy (DCM) in patients with isolated congenital complete atrioventricular block (CCAVB). BACKGROUND: Recently evidence has emerged that a subset of patients ... Full text Link to item Cite

Utility of three-dimensional computed tomographic angiography for assessment of relationships between the vertebrobasilar system and the cranial base.

Journal Article Neurosurgery · February 2001 OBJECTIVE: The optimal surgical exposure for basilar tip aneurysms is dictated by the relationship of the basilar bifurcation to the cranial base. This study was designed to evaluate three-dimensional computed tomographic angiography as a means of obtainin ... Full text Link to item Cite

Evaluation and surgical repair of brachial plexus injuries

Journal Article Seminars in Neurosurgery · January 1, 2001 Traumatic injuries of the brachial plexus may result in severe and permanent loss of motor and sensory function of the involved extremity. The neurosurgeon's ability to improve the functional outcome following a plexus injury requires an understanding of t ... Full text Cite

Phase I trial results of iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with newly diagnosed malignant gliomas.

Journal Article J Clin Oncol · November 15, 2000 PURPOSE: To determine the maximum-tolerated dose (MTD) of iodine-131 ((131)I)-labeled 81C6 antitenascin monoclonal antibody (mAb) administered clinically into surgically created resection cavities (SCRCs) in malignant glioma patients and to identify any ob ... Full text Link to item Cite

Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.

Journal Article J Clin Oncol · October 15, 2000 PURPOSE: The major mechanism of resistance to alkylnitrosourea therapy involves the DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (AGT), which removes chloroethylation or methylation damage from the O(6) position of guanine. O(6)-benzylguanine ... Full text Link to item Cite

Temozolomide delivered by intracerebral microinfusion is safe and efficacious against malignant gliomas in rats.

Journal Article Clin Cancer Res · October 2000 Intracerebral microinfusion (ICM) is an innovative technique of delivering therapeutic agents throughout large portions of the brain that circumvents the blood-brain barrier, minimizes systemic toxicity, and provides a homogeneous distribution of the infus ... Link to item Cite

Fiber dissection technique: lateral aspect of the brain.

Journal Article Neurosurgery · August 2000 OBJECTIVE: The fiber dissection technique involves peeling away the white matter tracts of the brain to display its three-dimensional anatomic organization. Early anatomists demonstrated many tracts and fasciculi of the brain using this technique. The comp ... Full text Link to item Cite

Inhibitory simple partial (non-convulsive) status epilepticus after intracranial surgery.

Journal Article J Neurol Neurosurg Psychiatry · July 2000 OBJECTIVES: To report on five patients who developed, 2 to 4 days after an intracranial neurosurgical procedure, new, persistent, focal neurological deficits which were due to inhibitory simple partial (non-convulsive) status epilepticus, and resolved with ... Full text Link to item Cite

Comparative genetic patterns of glioblastoma multiforme: potential diagnostic tool for tumor classification.

Journal Article Neuro Oncol · July 2000 Cytogenetic and molecular genetic studies of glioblastoma multiforme (GBM) have shown that the most frequent alterations are gains of chromosome 7, losses of 9p loci and chromosome 10, and gene amplification, primarily of the epidermal growth factor recept ... Full text Link to item Cite

Castleman's disease confined to the leptomeninges.

Journal Article Ann Clin Lab Sci · July 2000 We report a rare case of the plasma cell variant of Castleman's disease confined to the leptomeninges in a 42-year-old female. Flow cytometry demonstrated a minor monoclonal kappa light chain population, and conventional Southern blotting confirmed clonal ... Link to item Cite

Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · June 2000 The epidermal growth factor receptor (EGFR) is often amplified and rearranged structurally in tumors of the brain, breast, lung, and ovary. The most common mutation, EGFRvIII, is characterized by an in-frame deletion of 801 base pairs, resulting in the gen ... Full text Cite

Gliomas of the optic nerve: histological, immunohistochemical (MIB-1 and p53), and MRI analysis.

Journal Article Acta Neuropathol · May 2000 Gliomas of the optic nerve, although typically of pilocytic (WHO grade I) histology, can present within the spectrum of astrocytic neoplasia including glioblastoma (WHO grade IV). In certain cases, histologic features alone make the distinction between pil ... Full text Link to item Cite

A lost contact lens and Actinomyces colonization in an asymptomatic patient.

Journal Article Arch Ophthalmol · April 2000 Full text Link to item Cite

Parasitic lesion of the insula suggesting cerebral sparganosis: case report.

Journal Article Neuroradiology · March 2000 Cerebral sparganosis, a parasitic disease, rarely produces a chronic active inflammatory response in the brain. Clinically and radiographically the process may mimic a neoplasm. We report a 30-year-old man who underwent surgical exploration for a mass in t ... Full text Link to item Cite

Dosimetry and dose-response relationships in newly diagnosed patients with malignant gliomas treated with iodine-131-labeled anti-tenascin monoclonal antibody 81C6 therapy.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2000 PURPOSE: The objective of this study was to perform the dosimetry and evaluate the dose-response relationships in newly diagnosed patients with malignant brain tumors treated by direct injections of (131)I-labeled 81C6 monoclonal antibody (MAb) into surgic ... Full text Link to item Cite

Seizure outcome after temporal lobectomy for temporal lobe epilepsy: a Kaplan-Meier survival analysis.

Journal Article Neurology · February 8, 2000 OBJECTIVE: To determine seizure outcome and its predictors in patients with medically refractory temporal lobe epilepsy (TLE) after temporal lobectomy (TL). BACKGROUND: TL is the most common surgical procedure performed in adolescents and adults for the tr ... Full text Link to item Cite

Bone marrow-derived dendritic cells pulsed with tumor homogenate induce immunity against syngeneic intracerebral glioma.

Journal Article J Neuroimmunol · February 1, 2000 To evaluate the efficacy and toxicity of dendritic cell (DC) based therapy for intracerebral gliomas, we utilized a cell line derived from an astrocytoma that arose spontaneously in a VM/Dk mouse. This astrocytoma mirrors human gliomas phenotypically, morp ... Full text Link to item Cite

Effects of botulinum toxin A on upper limb spasticity in children with cerebral palsy.

Journal Article Am J Phys Med Rehabil · 2000 OBJECTIVE: Botulinum toxin A inhibits presynaptic release of acetylcholine at the neuromuscular junction and has reportedly been successful in the treatment of spastic disorders. This prospective study attempted to determine whether botulinum toxin A injec ... Full text Link to item Cite

A comparative clinicopathologic study of endogenous mycotic endophthalmitis: variations in clinical and histopathologic changes in candidiasis compared to aspergillosis.

Conference Trans Am Ophthalmol Soc · 2000 PURPOSE: Endophthalmitis caused by endogenous Candida and Aspergillus species has emerged as a visually threatening complication in patients with immune deficiency of various causes. Twenty-five patients who underwent enucleation, 13 with endogenous Asperg ... Link to item Cite

Cerebral hemorrhage and edema following brain biopsy in rats: significance of mean arterial blood pressure.

Journal Article J Neurosurg · January 2000 OBJECT: It is taken for granted that patients with hypertension are at greater risk for intracerebral hemorrhage during neurosurgical procedures than patients with normal blood pressure. The anesthesiologist, therefore, maintains mean arterial blood pressu ... Full text Link to item Cite

Resident curriculum guidelines for neurosurgery. Congress of Neurological Surgeons Education Committee.

Journal Article Clin Neurosurg · 2000 Link to item Cite

[Rubral tremor of Holmes, rare case of pathological tremor: case report].

Journal Article Neurol Neurochir Pol · 2000 The authors present a very rare case of Holmes tremor (previously known as rubral or midbrain tremor). In all described till now cases the tremor was due to a known and revealed in laboratory or neuroimaging cause. We present an unusual case of a 42-year o ... Link to item Cite

Carpal tunnel release: Surgical considerations

Journal Article Techniques in Neurosurgery · January 1, 2000 Entrapment of the median nerve at the carpal tunnel is the most common entrapment neuropathy. Although nocturnal paresthesias are the most common initial manifestation of carpal tunnel syndrome, the patient may also note hand numbness, clumsiness, pain rad ... Full text Cite

Three-dimensional ct angiography for planning skull base approaches to vertebrobasilar aneurysms: a radiographic and cadaveric study

Journal Article Skull Base Surgery · December 1, 1999 Three-dimensional CTA was evaluated as a means of acquiring detailed anatomic measurements of the relationships between bony landmarks at the base of the skull and the vertebrobasilar system. Thirty normal patients underwent CT angiography with 1-mm slices ... Cite

Three-dimensional ct angiography for evaluating anatomic variations of the skull base in the region of the intrapetrous carotid

Journal Article Skull Base Surgery · December 1, 1999 Introduction: We evaluated 3-D CTA as a means of obtaining detailed anatomic information regarding differences in bony landmarks and spatial relationships in the region of the petrous carotid. Methods: Thirty patients underwent CT angiography with 1-mm sli ... Cite

Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor Group.

Journal Article J Clin Oncol · September 1999 PURPOSE: To determine the antitumor efficacy and safety profile of temozolomide in patients with malignant astrocytoma at first relapse. PATIENTS AND METHODS: This open-label, multicenter, phase II trial enrolled 162 patients (intent-to-treat [ITT] populat ... Full text Link to item Cite

Regional treatment of epidermal growth factor receptor vIII-expressing neoplastic meningitis with a single-chain immunotoxin, MR-1.

Journal Article Clin Cancer Res · September 1999 The incidence of neoplastic meningitis is on the rise. Neoplastic meningitis can result from a direct seeding of the neuraxis by primary brain tumors or by hematogeneous spread of systemic solid tumors. A frequent genetic alteration in primary brain tumors ... Link to item Cite

Molecular genetic aspects of oligodendrogliomas including analysis by comparative genomic hybridization.

Journal Article Am J Pathol · August 1999 Oligodendroglial neoplasms are a subgroup of gliomas with distinctive morphological characteristics. In the present study we have evaluated a series of these tumors to define their molecular profiles and to determine whether there is a relationship between ... Full text Link to item Cite

Eyelid healing after carbon dioxide laser skin resurfacing: histological analysis.

Journal Article Arch Ophthalmol · July 1999 OBJECTIVE: To clarify in vivo healing of eyelid skin after carbon dioxide (CO2) laser resurfacing. DESIGN: Patients requesting upper eyelid blepharoplasty consented to undergo previous CO2 laser skin resurfacing of the upper eyelid skin segments to be exci ... Full text Link to item Cite

Treatment of neoplastic meningitis with intrathecal temozolomide.

Journal Article Clin Cancer Res · May 1999 Neoplastic meningitis (NM) results from leptomeningeal dissemination of cancers arising within the central nervous system or metastasizing to the leptomeninges from systemic neoplasms. The inability to produce therapeutic drug levels intrathecally (i.t.) w ... Link to item Cite

Irinotecan therapy in adults with recurrent or progressive malignant glioma.

Journal Article J Clin Oncol · May 1999 PURPOSE: To determine the activity, toxicity, and pharmacokinetics of irinotecan (CPT-11, Camptosar; Pharmacia & Upjohn, Kalamazoo, MI) in the treatment of adults with progressive, persistent, or recurrent malignant glioma. PATIENTS AND METHODS: Patients w ... Full text Link to item Cite

Fractionated external-beam radiation therapy for meningiomas of the cavernous sinus.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 1999 PURPOSE: Despite advances in microsurgical technique, many cavernous sinus meningiomas remain unresectable or only partially resectable, prompting referral of patients for radiation therapy. Stereotactic radiosurgery is recommended as therapy at some insti ... Full text Link to item Cite

Dosimetry of 131I-labeled 81C6 monoclonal antibody administered into surgically created resection cavities in patients with malignant brain tumors.

Journal Article J Nucl Med · April 1999 UNLABELLED: The objective of this study was to perform the dosimetry of 131I-labeled 81C6 monoclonal antibody (MAb) in patients with recurrent malignant brain tumors, treated by direct injections of MAb into surgically created resection cavities (SCRCs). M ... Link to item Cite

Topotecan treatment of adults with primary malignant glioma. The Brain Tumor Center at Duke.

Journal Article Cancer · March 1, 1999 BACKGROUND: Topotecan activity was evaluated for the treatment of malignant glioma. METHODS: Sixty-three patients with newly diagnosed (n = 25) or recurrent (n = 38) malignant glioma were treated with topotecan [AU: Please verify all dosages here and throu ... Link to item Cite

Diagnosis of phacoanaphylactic endophthalmitis by fine needle aspiration biopsy.

Journal Article Ophthalmic Surg Lasers · February 1999 Diagnosis of phacoanaphylactic endophthalmitis (or lens induced uveitis), a rare autoimmune disease, is difficult due to variable clinical presentation. We sought to diagnose a case based on the cytopathology of the anterior chamber aspirate. This is a cas ... Link to item Cite

Correlation of hippocampal neuronal density and FDG-PET in mesial temporal lobe epilepsy.

Journal Article Epilepsia · January 1999 PURPOSE: Interictal [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) reveals regional hypometabolism in 60-80% of patients with mesial temporal lobe epilepsy (MTLE). The extent of hypometabolism generally extends beyond the epileptogenic zo ... Full text Link to item Cite

Chemotherapy for adults with malignant glioma.

Journal Article Cancer Invest · 1999 Full text Link to item Cite

Intrathecal busulfan treatment of human neoplastic meningitis in athymic nude rats.

Journal Article J Neurooncol · 1999 The current study was designed to evaluate the toxicity and activity of Spartaject Busulfan, a microcrystalline preparation of busulfan, following its intrathecal administration into a nude rat model of human neoplastic meningitis. Animals were treated thr ... Full text Link to item Cite

DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma.

Journal Article J Clin Oncol · December 1998 PURPOSE: We evaluated the response to Temodal (Schering-Plough Research Institute, Kenilworth, NJ) of patients with newly diagnosed malignant glioma, as well as the predictive value of quantifying tumor DNA mismatch repair activity and O6-alkylguanine-DNA ... Full text Link to item Cite

Seizure onset from periventricular nodular heterotopias: depth-electrode study.

Journal Article Neurology · December 1998 The association between gray matter heterotopias and seizures is well established; whether seizures originate from these lesions is not known. We evaluated three patients with intractable complex partial seizures and periventricular nodular heterotopias (P ... Full text Link to item Cite

Gliomas.

Journal Article Eur J Cancer · November 1998 Full text Link to item Cite

Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma.

Journal Article J Clin Oncol · November 1998 PURPOSE: The major mechanism of resistance to alkylnitrosourea therapy is the DNA repair protein O6-alkylguanine-DNA alkyltransferase (AGT), which removes chlorethylation or methylation damage from the O6-position of guanine. O6-benzylguanine (O6-BG) is an ... Full text Link to item Cite

Case 4--1998. Cardiopulmonary bypass and hypothermic circulatory arrest for basilar artery aneurysm clipping.

Journal Article J Cardiothorac Vasc Anesth · August 1998 Full text Link to item Cite

Treatment of adults with progressive oligodendroglioma with carboplatin (CBDCA): preliminary results. Writing Committee for The Brain Tumor Center at Duke.

Journal Article Med Pediatr Oncol · July 1998 BACKGROUND: Exploration of the role of chemotherapy in the treatment of low grade glioma, including oligodendroglioma, has been limited to the pediatric population, reflecting the sensitivity of young patients to radiation-induced toxicity and a desire to ... Full text Link to item Cite

Retinopathy associated with pancreatitis in a child with maple syrup urine disease.

Journal Article Br J Ophthalmol · July 1998 Full text Link to item Cite

Surgical outcome in patients with epilepsy with occult vascular malformations treated with lesionectomy.

Journal Article Epilepsia · June 1998 PURPOSE: This retrospective study reports the long-term surgical outcome of patients with medically refractory epilepsy and vascular malformations who were treated with lesionectomy. A detailed analysis of surgical failures had been performed in an attempt ... Full text Link to item Cite

Iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with recurrent malignant gliomas: phase I trial results.

Journal Article J Clin Oncol · June 1998 PURPOSE: To determine the maximum-tolerated dose (MTD) of iodine 131 (131I)-labeled 81C6 monoclonal antibody (mAb) in brain tumor patients with surgically created resection cavities (SCRCs) and to identify any objective responses to this treatment. METHODS ... Full text Link to item Cite

Analysis of DNA mismatch repair proteins in human medulloblastoma.

Journal Article Clin Cancer Res · June 1998 During replication, the primary function of the eukaryotic DNA mismatch repair (MMR) system is to recognize and correct mismatched base pairs within the DNA helix. Deficiencies in MMR have been reported previously in cases of hereditary nonpolyposis colore ... Link to item Cite

Phase II study of carboplatin (CBDCA) in progressive low-grade gliomas.

Journal Article Neurosurg Focus · April 15, 1998 In this study, the authors sought to investigate the response rate and toxicity of carboplatin in patients with progressive low-grade glioma (LGG). Thirty-two patients with progressive LGG were treated with carboplatin at a dosage of 560 mg/m(2). Treatment ... Full text Link to item Cite

Images in cardiovascular medicine. Kawasaki disease: coronary aneurysms in mother and son.

Journal Article Circulation · February 3, 1998 Full text Link to item Cite

Demographics, prognosis, and therapy in 702 patients with brain metastases from malignant melanoma.

Journal Article J Neurosurg · January 1998 UNLABELLED: Brain metastases are a common and devastating complication in patients with malignant melanoma. Therapeutic options for these patients are limited, and the prognosis is usually poor. OBJECT: A retrospective review of 6953 patients with melanoma ... Full text Link to item Cite

PTEN gene mutations are seen in high-grade but not in low-grade gliomas.

Journal Article Cancer Res · October 1, 1997 The PTEN gene, located on 10q23, has recently been implicated as a candidate tumor suppressor gene in brain, breast and prostate tumors. In the present study, 123 brain tumors, including various grades and histological types of gliomas occurring in childre ... Link to item Cite

Cell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor, EGFRvIII.

Journal Article Cancer Res · September 15, 1997 The potential of therapeutic targeting of tumor cell surface epidermal growth factor receptors (EGFRs) by modified ligands or specific antibodies has been limited by the normal tissue distribution of the receptor. The identification and characterization of ... Link to item Cite

Clinical and electrographic manifestations of lesional neocortical temporal lobe epilepsy.

Journal Article Neurology · September 1997 To determine whether lesional neocortical temporal lobe epilepsy (NTLE) can be differentiated from mesial temporal lobe epilepsy (MTLE) during the noninvasive presurgical evaluation, we compared the historical features, seizure symptomatology, and surface ... Full text Link to item Cite

Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial: 5. Clinical features of cytomegalovirus retinitis at diagnosis. Studies of ocular complications of AIDS Research Group in collaboration with the AIDS Clinical Trials Group.

Journal Article Am J Ophthalmol · August 1997 PURPOSE: To examine associations of systemic and ocular characteristics with severity of cytomegalovirus (CMV) retinitis at time of diagnosis and to compare ocular characteristics of eyes with and without CMV retinitis. METHODS: Eleven clinical centers, a ... Link to item Cite

Sex hormones and renal nitric oxide synthases.

Journal Article J Am Soc Nephrol · August 1997 The present study was undertaken to determine whether sex hormones influence nitric oxide synthase levels in the kidney. Five groups of rats were studied: males, castrated males, females, oophorectomized females, and oophorectomized females receiving estra ... Full text Link to item Cite

Complications in the treatment of carpal tunnel syndrome.

Journal Article Neurosurg Focus · July 15, 1997 Complications may result from every facet of the management of carpal tunnel syndrome. The authors review the common errors in diagnosis, nonoperative management, and operative treatment, with emphasis on prevention and resolution of complications. In gene ... Full text Link to item Cite

Surgical anatomy of the carpal tunnel.

Journal Article Neurosurg Focus · July 15, 1997 The author describes and details the anatomy of the carpal tunnel and surrounding structures pertinent to the surgical treatment of carpal tunnel syndrome. Potential complications of both open and endoscopic carpal tunnel release are discussed as well as t ... Full text Link to item Cite

Rhegmatogenous retinal detachment in patients with cytomegalovirus retinitis: the Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial. The Studies of Ocular Complications of AIDS (SOCA) Research Group in Collaboration with the AIDS Clinical Trials Group (ACTG).

Journal Article Am J Ophthalmol · July 1997 PURPOSE: To determine the incidence and risk factors for rhegmatogenous retinal detachment in a population of patients with newly diagnosed cytomegalovirus retinitis. METHODS: Analysis of selected baseline and time-dependent data on patients enrolled in a ... Link to item Cite

Management of fetal cardiac arrhythmias.

Journal Article Obstet Gynecol Clin North Am · March 1997 While most fetal cardiac arrhythmias are benign in nature, some may be dangerous and require prenatal treatment. This article reviews the differential diagnoses of fetal tachycardias and bradycardias, as well as treatment and management approaches. ... Full text Link to item Cite

Brachial plexus compression by venous aneurysms. Case illustration.

Journal Article J Neurosurg · February 1997 Full text Link to item Cite

Craniocerebral plasmacytoma: MR features.

Journal Article AJNR Am J Neuroradiol · February 1997 We report the MR imaging findings in two patients with solitary craniocerebral plasmacytoma, a benign plasma cell tumor that can arise from the skull, the dura, or, rarely, the brain. In both patients, the lesion was extraaxial and nearly isointense with g ... Link to item Cite

Long-term follow-up after uveal melanoma charged particle therapy.

Conference Trans Am Ophthalmol Soc · 1997 PURPOSE: To examine the results of helium ion irradiation in 218 uveal melanoma patients treated more than 10 years ago. METHODS: Retrospective review of 218 eyes treated with helium ion radiation for uveal melanoma between 1978 and 1984. Several parametri ... Link to item Cite

A pathologic study of degeneration of the rod and cone populations of the rhodopsin Pro347Leu transgenic pigs.

Journal Article Trans Am Ophthalmol Soc · 1997 PURPOSE: Transgenic pigs with rhodopsin (Pro347Leu) mutation exhibited rod-cone degeneration. We compared the pathologic characteristics of the rod degeneration versus those of the cone cells. METHODS: The posterior and peripheral retinas of these transgen ... Link to item Cite

Predictors of outcome of epilepsy surgery: multivariate analysis with validation.

Journal Article Epilepsia · September 1996 PURPOSE: To identify predictors of outcome of epilepsy surgery, using the Duke experience, applying multivariate analysis and validation techniques. To compare the results of different modeling algorithms. Few previous studies have reported multivariate an ... Full text Link to item Cite

Autosomal dominant cataracts of the fetus: early detection by transvaginal ultrasound.

Journal Article Ultrasound Obstet Gynecol · August 1996 Cataracts are lens opacities that account for approximately 10% of blindness in children. We report on four consecutive pregnancies in a woman at risk for recurrent autosomal dominant cataracts in which extensive ultrasound studies were helpful in establis ... Full text Link to item Cite

Intrathecal 131I-labeled antitenascin monoclonal antibody 81C6 treatment of patients with leptomeningeal neoplasms or primary brain tumor resection cavities with subarachnoid communication: phase I trial results.

Journal Article Clin Cancer Res · June 1996 We aimed to determine the maximum tolerated dose (MTD) of 131I-labeled 81C6 in patients with leptomeningeal neoplasms or brain tumor resection cavities with subarachnoid communication and to identify any objective responses. 81C6 is a murine IgG monoclonal ... Link to item Cite

A phase III randomized prospective trial of external beam radiotherapy, mitomycin C, carmustine, and 6-mercaptopurine for the treatment of adults with anaplastic glioma of the brain. CNS Cancer Consortium.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 1996 PURPOSE: This study was designed to evaluate strategies to overcome the resistance of anaplastic gliomas of the brain to external beam radiotherapy (ERT) plus carmustine (BCNU). Patients were > or = 15 years of age, had a histologic diagnosis of malignant ... Full text Link to item Cite

Neuro-Behcet's disease in Japan - Reply

Journal Article NEUROLOGY · 1996 Full text Cite

Ipsilateral facial and uveal arteriovenous and capillary angioma, microphthalmos, heterochromia of the iris, and hypotony: an oculocutaneous syndrome simulating Sturge-Weber syndrome.

Conference Trans Am Ophthalmol Soc · 1996 Sturge-Weber syndrome is a disorder characterized by ipsilateral cavernous hemangioma of the face, uvea, and brain in patients who may present with an enlarged eye, exudative retinal detachment, glaucoma, and seizures. This report presents the clinicopatho ... Link to item Cite

Apoptosis in human retinal degenerations.

Conference Trans Am Ophthalmol Soc · 1996 PURPOSE: This paper examined the role of apoptosis in human retinal degenerations including pathologic myopia, age-related macular degeneration, serous retinal detachment, retinal lattice, and paving stone degenerations. METHOD: Thirty-seven enucleated hum ... Link to item Cite

Outcome of temporal lobectomy in adolescents

Journal Article Journal of Epilepsy · January 1, 1996 We performed temporal lobectomy in 23 young patients with intractable complex partial seizures (CPS) at an average age of 14.5 years. At a mean follow-up interval of 4.8 years, we reevaluated the patients to assess the surgical outcome; 74% were seizure-fr ... Full text Cite

Progressive outer retinal necrosis.

Journal Article Ophthalmology · December 1995 Full text Link to item Cite

Perioperative management of aneurysmal subarachnoid hemorrhage: Part 2. Postoperative management.

Journal Article Anesth Analg · December 1995 Full text Link to item Cite

Perioperative management of aneurysmal subarachnoid hemorrhage: Part 1. Operative management.

Journal Article Anesth Analg · November 1995 Full text Link to item Cite

Thrombosis of the pulmonary artery stump after distal ligation.

Journal Article J Thorac Cardiovasc Surg · November 1995 Full text Link to item Cite

Thromboembolic complications after Fontan operations.

Journal Article Circulation · November 1, 1995 BACKGROUND: Despite the increasing recognition of thromboembolic complications of the Fontan procedure, data characterizing such events are limited. The total cavopulmonary connection is believed to be less prone to this complication than other modificatio ... Full text Link to item Cite

The risk of intracranial aneurysms in families with subarachnoid hemorrhage.

Journal Article Can J Neurol Sci · November 1995 Full text Link to item Cite

Metastatic melanoma to the spine. Demographics, risk factors, and prognosis in 114 patients.

Journal Article Spine (Phila Pa 1976) · October 1, 1995 STUDY DESIGN: One-hundred-fourteen patients with metastatic melanoma of the spine were retrospectively reviewed. OBJECTIVE: The goal was to define the demographics, risk factors, and prognosis for this population. SUMMARY OF BACKGROUND DATA: The incidence ... Full text Link to item Cite

Fast spin-echo, magnetic resonance imaging-measured hippocampal volume: correlation with neuronal density in anterior temporal lobectomy patients.

Journal Article Epilepsia · September 1995 To assess the value of magnetic resonance imaging (MRI)-measured hippocampal volume in the detection of hippocampal sclerosis, we studied 28 patients undergoing anterior temporal lobectomy for medically intractable mesial temporal lobe epilepsy. Hippocampa ... Full text Link to item Cite

Neuro-Behçet's disease: factors hampering proper diagnosis.

Journal Article Neurology · September 1995 We reviewed the clinical course of nine patients with neuro-Behçet's disease to assess difficulties in making this diagnosis. Factors delaying proper diagnosis included lack of accurate history and physical examination, lack of recognition of an underlying ... Full text Link to item Cite

Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25.

Other Oncogene · June 1, 1995 The high incidence of loss of chromosome 10 alleles in glioblastoma multiforme suggests the presence on this chromosome of a tumor suppressor gene that is important in glioma tumorigenesis and progression. Our initial deletion mapping studies using restric ... Link to item Cite

Medical complications of aneurysmal subarachnoid hemorrhage: a report of the multicenter, cooperative aneurysm study. Participants of the Multicenter Cooperative Aneurysm Study.

Journal Article Crit Care Med · June 1995 OBJECTIVES: This report examines the frequency, type, and prognostic factors of medical (nonneurologic) complications after subarachnoid hemorrhage in a large, prospective study. The influences of contemporary neurosurgical, neurological, and critical care ... Full text Link to item Cite

The restoration of elbow flexion with intercostal nerve transfers.

Journal Article Clin Orthop Relat Res · May 1995 Seventeen patients with absent elbow flexion secondary to brachial plexus avulsion injury underwent intercostal neurotization of the biceps muscle. Followup was performed at an average of 5 years. The average age in this series was 21.8 years; the mean tim ... Link to item Cite

Risk of intracranial aneurysms in families with subarachnoid hemorrhage.

Journal Article Can J Neurol Sci · May 1995 BACKGROUND: Genetic factors may be important in the etiology of subarachnoid hemorrhage (SAH) and intracranial aneurysm (IA) formation. Several studies have reported the familial occurrence of SAH and IA, although in most cases asymptomatic family members ... Full text Link to item Cite

Fast spin-echo MR in hippocampal sclerosis: correlation with pathology and surgery.

Journal Article AJNR Am J Neuroradiol · April 1995 PURPOSE: To identify the extent of hippocampal sclerosis in temporal lobe epilepsy with fast spin-echo MR and correlate it with histopathologic findings and surgical outcome. METHODS: MR images of 30 patients with temporal lobe epilepsy and pathologically ... Link to item Cite

Shadow cells in an intracranial dermoid cyst.

Journal Article Arch Pathol Lab Med · April 1995 A case of an intracranial dermoid cyst containing shadow cells is presented. This case expands the group of lesions in which shadow cells, indicative of hair matrical differentiation, have been described. ... Link to item Cite

Reply

Journal Article Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · January 1, 1995 Full text Cite

Surgery for stroke

Journal Article Neurosurgery · January 1, 1995 Full text Cite

Vascular malformations presenting as spinal cord neoplasms: case report.

Journal Article Neurosurgery · January 1995 Three cases of adult patients with subacute courses of progressive caudal spinal cord disease are presented. Computed tomography, magnetic resonance imaging, and myelographic studies were interpreted preoperatively as representing a spinal cord neoplasm in ... Full text Link to item Cite

Dorsal root entry zone lesions for intractable pain after trauma to the conus medullaris and cauda equina.

Journal Article J Neurosurg · January 1995 This review was undertaken to determine the efficacy of using dorsal root entry zone (DREZ) lesions to treat intractable pain caused by trauma to the conus medullaris and cauda equina. Traumatic lesions of this area are unique in that both the spinal cord ... Full text Link to item Cite

Phase I studies of treatment of malignant gliomas and neoplastic meningitis with 131I-radiolabeled monoclonal antibodies anti-tenascin 81C6 and anti-chondroitin proteoglycan sulfate Me1-14 F (ab')2--a preliminary report.

Journal Article J Neurooncol · 1995 The advent of monoclonal antibody (MAb) technology has made Ehrlich's postulate of the 'magic bullet' an attainable goal. Although specific localization of polyvalent antibodies to human gliomas was demonstrated in the 1960s, the lack of specific, high aff ... Full text Link to item Cite

Childhood dural arteriovenous fistulae of the posterior dural sinuses: Three case reports and literature review

Journal Article Neurosurgery · 1995 WE REPORT THREE cases of posterior dural sinus arteriovenous fistulae in pediatric patients and a literature review of 18 additional cases. These lesions carry a grave prognosis with a reported mortality of 38% and with an historical anatomic cure of only ... Cite

Association and chance occurrence of aniridia and retinoblastoma.

Journal Article Am J Ophthalmol · December 15, 1994 PURPOSE/METHODS: A 9-month-old infant had inherited aniridia and unilateral retinoblastoma. Family history disclosed three generations of aniridia; yet there were no instances of retinoblastoma. The coincidental occurrence of retinoblastoma and aniridia is ... Full text Link to item Cite

Ipsilateral subcortical atrophy associated with temporal lobectomy.

Journal Article Psychiatry Res · December 1994 Stereologic methods for determining the volume of cerebral structures in vivo via magnetic resonance imaging have identified unilateral hippocampal atrophy among patients with complex partial epilepsy of temporal lobe origin. Metabolic imaging has also ide ... Full text Link to item Cite

Treatment of radiation-induced nervous system injury with heparin and warfarin.

Journal Article Neurology · November 1994 When radiation is used to treat nervous system cancer, exposure of adjacent normal nervous system tissue is unavoidable, and radiation-induced injury may occur. Acute injury is usually mild and transient, but late forms of radiation-induced nervous system ... Full text Link to item Cite

MR and positron emission tomography in the diagnosis of surgically correctable temporal lobe epilepsy.

Journal Article AJNR Am J Neuroradiol · August 1994 PURPOSE: To determine the association of an MR abnormality and a positron emission tomography (PET) abnormality with a good outcome in patients with temporal lobe epilepsy after lobectomy, the association of combined PET and MR findings with good outcomes ... Link to item Cite

Regarding "A moment with endocrinology and metabolism" Maryland Medical Journal November 1993.

Journal Article Md Med J · April 1994 Link to item Cite

Neuronal migration disorders: positron emission tomography correlations.

Journal Article Ann Neurol · March 1994 We analyzed the interictal [18F]fluoro-2-deoxy-D-glucose positron emission tomography (PET) findings of 17 epileptic patients with neuronal migration disorders (NMDs). Fifteen patients had abnormal PET findings, i.e., focal hypometabolism in 9 patients and ... Full text Link to item Cite

Alterations of the TP53 gene in human gliomas.

Journal Article Cancer Res · March 1, 1994 Glial tumors of all grades and histological types from 72 adults and 48 children were analyzed for mutations of the TP53 gene, loss of heterozygosity (LOH) for 17p, and accumulation of TP53 protein to determine whether the incidence and type of TP53 altera ... Link to item Cite

Giant Cavernous Hemangioma of the Face-Reply

Journal Article Archives of Ophthalmology · January 1, 1994 Full text Cite

Retinal and choroidal biopsy in intraocular inflammation: a clinicopathologi study.

Conference Trans Am Ophthalmol Soc · 1994 Link to item Cite

Giant cavernous hemangioma of the face.

Journal Article Arch Ophthalmol · January 1994 Full text Link to item Cite

Positron emission tomography: Comparison of clinical utility in temporal lobe and extratemporal epilepsy

Journal Article Journal of Epilepsy · January 1, 1994 Sixty consecutive patients admitted for possible surgical treatment of intractable epilepsy underwent 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) as part of a standardized presurgical protocol. Patients were classified as having tempora ... Full text Cite

Complex partial seizures and mesial temporal sclerosis: evaluation with fast spin-echo MR imaging.

Journal Article Radiology · December 1993 PURPOSE: This study was performed to determine the sensitivity and specificity of fast spin-echo (FSE) magnetic resonance (MR) imaging in detecting mesial temporal sclerosis. MATERIALS AND METHODS: Twenty-one patients with a diagnosis of complex partial se ... Full text Link to item Cite

Temporal lobe hypometabolism on PET: predictor of seizure control after temporal lobectomy.

Journal Article Neurology · June 1993 To investigate the relationship of temporal lobe hypometabolism demonstrated on PET to surgical outcome and underlying pathology, we reviewed 30 consecutive epilepsy patients who underwent interictal PET studies with 18F fluorodeoxyglucose before temporal ... Full text Link to item Cite

Distribution and dosimetry of I-123-labeled monoclonal antibody 81C6 in patients with anaplastic glioma.

Journal Article Invest Radiol · June 1993 RATIONALE AND OBJECTIVES: Monoclonal antibody 81C6 reacts with the extracellular matrix antigen, tenascin, present on gliomas and other tumors, as well as several normal tissues, including spleen and liver tissue. Single photon emission computed tomography ... Link to item Cite

3-dimensional optimization of multiple arcs for stereotactic radiosurgery.

Journal Article Int J Radiat Oncol Biol Phys · April 30, 1993 PURPOSE: During linear accelerator-based radiosurgery, the physicians and physicists need to determine which combination of treatment arcs are "best" with regard to target coverage and incidental dose to adjacent structures. This is a complex problem, espe ... Full text Link to item Cite

The transition from fetal to neonatal circulation: normal responses and implications for infants with heart disease.

Journal Article Semin Perinatol · April 1993 The primary function of the circulatory system of both the fetus and newborn is to deliver oxygen to metabolizing organs and return deoxygenated blood to the gas exchange organ to replenish the oxygen and eliminate the waste product CO2. In the fetus, the ... Link to item Cite

Fetal echocardiography and fetal cardiology: indications, diagnosis and management.

Journal Article Semin Perinatol · April 1993 Over the last 15 years, the ultrasound examination of the fetal heart has become increasingly sophisticated. Fetal echocardiography is now paramount in making an early and accurate assessment of cardiovascular structure as well as diagnosing and treating f ... Link to item Cite

Epidural spinal metastases from malignant melanoma: Demographics, prognosis and treatment.

Journal Article Canadian Journal of Neurological Sciences · 1993 Cite

Ocular manifestations of the acquired immunodeficiency syndrome

Journal Article Current Opinion in Ophthalmology · January 1, 1993 New findings continue to appear in the study of the eyes of AIDS patients. Disturbances in color vision and contrast threshold have been noted. Central retinal vein occlusion has been reported. Retrobulbar optic neuropathy is another new finding. Cytomegal ... Full text Cite

Treatment of spasmodic torticollis with intradural selective rhizotomies.

Journal Article J Neurosurg · January 1993 To determine the effects of ventral cervical and selective spinal accessory nerve rhizotomy on spasmodic torticollis, 58 patients who had undergone surgery between 1979 and 1987 were reviewed retrospectively. At the time of surgery, each nerve rootlet was ... Full text Link to item Cite

Correlation between function and structure in "epileptic" human hippocampal tissue maintained in vitro.

Journal Article Epilepsia · 1993 Intracellular and extracellular recordings were obtained from the CA1 region and gyrus dentatus of human hippocampi that had been surgically removed for treatment of intractable seizures. Pathologic diagnoses were obtained, and electrophysiologic results w ... Full text Link to item Cite

[18F]2-fluoro-2-deoxyglucose-positron emission tomography correlation of gadolinium-enhanced MR imaging of central nervous system neoplasia.

Journal Article AJNR Am J Neuroradiol · 1993 PURPOSE: To correlate the findings of gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA)-enhanced MR imaging with positron emission tomography (PET) in the evaluation of central nervous system neoplasia. MATERIALS AND METHODS: Thirty-six lesions ident ... Link to item Cite

[¹⁸F]2-fluoro-2-deoxyglucose-positron emission tomography correlation of gadolinium-enhanced MR imaging of central nervous system neoplasia

Journal Article American Journal of Neuroradiology · 1993 PURPOSE: To correlate the findings of gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA)enhanced MR imaging with positron emission tomography (PET) in the evaluation of central nervous system neoplasia. MATERIALS AND METHODS: Thirty-six lesions identi ... Cite

Lymph node sampling in patients with epithelial ovarian carcinoma.

Journal Article Gynecol Oncol · November 1992 Lymph node sampling is part of the FIGO staging of patients with ovarian carcinoma and is usually part of a meticulous second look operation. We analyzed the primary lymph node status of patients and compared this to the lymph node status at second look op ... Full text Link to item Cite

Solitary eosinophilic granuloma invading the clivus of an adult: case report.

Journal Article Neurosurgery · October 1992 A 41-year-old white man with facial pain and diplopia was found to have an invasive lesion of the clivus. The final pathological diagnosis was eosinophilic granuloma. The patient's symptoms resolved completely after transsphenoidal resection of the lesion. ... Full text Link to item Cite

Loss of heterozygosity for 10q loci in human gliomas.

Journal Article Genes Chromosomes Cancer · July 1992 Cytogenetic and RFLP studies have shown that chromosome 10 is frequently lost in tumor cells from glioblastomas, suggesting that a suppressor gene important in tumorigenesis is present on this chromosome. Forty-one tumors were examined for loss of heterozy ... Full text Link to item Cite

Exophytic syrinx, an extreme form of syringomyelia: CT, myelographic, and MR imaging features.

Journal Article Radiology · April 1992 Magnetic resonance (MR) imaging and computed tomography (CT) were used to study severe syringomyelia, in which the syrinx was so eccentric relative to the center of the spinal cord that at initial examination it appeared to be an exophytic extramedullary m ... Full text Link to item Cite

Bilateral transpedicular decompression and Harrington rod stabilization in the management of severe thoracolumbar burst fractures.

Journal Article Spine (Phila Pa 1976) · February 1992 Fifty-eight patients with severe thoracolumbar burst fractures were treated with bilateral transpedicular decompression, Harrington rod instrumentation, and spine fusion. Spinal realignment and stabilization was achieved by contoured dual Harrington distra ... Full text Link to item Cite

Peripheral nerve repair with collagen tubes

Journal Article Neurosurgery · January 1, 1992 Full text Cite

Uveitis and infectious diseases: Editorial overview

Journal Article Current Opinion in Ophthalmology · January 1, 1992 Full text Cite

Sex differences in vulnerability and maladjustment as a function of parental investment: an evolutionary approach.

Journal Article Soc Biol · 1992 Sex differences in aspects of mental health are examined as a function of uneven parental investment in children. Relative vulnerability is a new construct mediating the influence of parental investment on mental health. Couples (129) in three stages of th ... Full text Link to item Cite

Opportunistic intraocular infections in AIDS.

Conference Trans Am Ophthalmol Soc · 1992 In conclusion, this clinicopathologic study has shown that CMV ocular infection is present in about 16% of terminal AIDS patients. The treatment of CMV retinitis reduces the number of CMV-infected nonocular organs and may also lessen the severity and contr ... Link to item Cite

Phase I study of BCNU and intravenous 6-mercaptopurine in patients with anaplastic gliomas.

Journal Article Cancer Chemother Pharmacol · 1992 On the basis of response rates of up to 50%, BCNU [1,3-bis(2-chloroethyl)-1-nitrosourea] is the primary drug used in the chemotherapy of anaplastic gliomas. Preclinical data obtained in several experimental systems show that the cytotoxicity of chloroethyl ... Full text Link to item Cite

Screening indices for cytomegalovirus retinitis in patients with human immunodeficiency virus.

Journal Article Mt Sinai J Med · January 1992 Cytomegalovirus retinitis, the major cause of blindness in patients with the acquired immunodeficiency syndrome, can be arrested by early detection and treatment. We identified 9 screening indices for early CMV retinitis: T-4/T-8 ratio less than 0.11, T-4 ... Link to item Cite

Systemic antiviral drugs used in ophthalmology.

Journal Article Surv Ophthalmol · 1992 Over the past two decades, the recognition of viral enzymes and proteins that can serve as molecular targets of drugs has revolutionized the treatment of viral infections. Beginning with acyclovir, a number of systemically administered agents which are bot ... Full text Link to item Cite

Comparison of the human electro-oculographic response to green and near-ultraviolet stimuli.

Journal Article Doc Ophthalmol · 1992 We recorded the electro-oculogram from 27 normal subjects by means of green and near-ultraviolet (UVA) stimulation. After a 40-minute dark-adaptation period, baseline responses were recorded. In response to the green stimulus, the electro-oculogram increas ... Full text Link to item Cite

Influence of the type of surgery on the histologic diagnosis in patients with anaplastic gliomas.

Journal Article Neurology · November 1991 Stereotactic biopsy of CNS tumors provides a small amount of tissue for pathologic diagnosis. This potentially leads to inaccurate grading of gliomas because of their histologic heterogeneity. We compared histologic diagnoses in a consecutive series of 329 ... Full text Link to item Cite

Loss of hippocampal acetylcholinesterase staining after fornix lesion in the monkey.

Journal Article Exp Neurol · October 1991 Cholinergic denervation of the hippocampal formation has been extensively studied in rodents but not in primates. Therefore we studied the changes in acetylcholinesterase histochemical staining of the hippocampus occurring after bilateral transection of th ... Full text Link to item Cite

Identification of amiodarone in corneal deposits.

Journal Article Am J Ophthalmol · April 15, 1991 Full text Link to item Cite

Ganglioglioma: a clinical study with long-term follow-up.

Journal Article Surg Neurol · April 1991 Gangliogliomas are uncommon tumors of mixed neoplastic glial and neuronal elements. Because of their low incidence, few large series exist that fully describe the clinical characteristics of patients afflicted with this tumor. We have reviewed the medical ... Full text Link to item Cite

Identification of early recurrence of primary central nervous system tumors by [18F]fluorodeoxyglucose positron emission tomography.

Journal Article Ann Neurol · April 1991 As aggressive neurosurgery and adjuvant therapy have become standard care for most patients with primary central nervous system (CNS) tumors, limitations of posttreatment neuroimaging techniques have become more apparent. Interpretation of computed cranial ... Full text Link to item Cite

Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas.

Journal Article J Neurosurg · March 1991 Malignant gliomas have been difficult to treat with chemotherapy. The most effective agent, BCNU (carmustine), has considerable systemic toxicity and a short half-life in serum. To obviate these problems, a method has been developed for the local sustained ... Full text Link to item Cite

Hemangiopericytoma of the sciatic nerve. Case report.

Journal Article J Neurosurg · March 1991 The authors report the case of a hemangiopericytoma arising in a sciatic nerve. It was found to be invasive within the epineurium but sparing surrounding tissues. Adequate resection required sacrifice of the nerve. Hemangiopericytomas can be added to the s ... Full text Link to item Cite

Increased AMPA-sensitive quisqualate receptor binding and reduced NMDA receptor binding in epileptic human hippocampus.

Journal Article J Neurosci · February 1991 Based on results from the kindling model of epilepsy, we hypothesized that enhanced binding of radioligands to the NMDA receptor and decreased binding to the alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionate (AMPA)-sensitive quisqualate (ASQ) receptor ... Full text Link to item Cite

Pneumocystis carinii choroiditis after long-term aerosolized pentamidine therapy.

Journal Article Am J Ophthalmol · January 15, 1991 Full text Link to item Cite

Uveitis and infectious diseases: Editorial overview

Journal Article Current Opinion in Ophthalmology · January 1, 1991 Cite

Neurotization of elements of the brachial plexus.

Journal Article Neurosurg Clin N Am · January 1991 Satisfactory therapy for an avulsion injury of the brachial plexus has yet to be described. Dorsal root entry zone lesions will usually mitigate the searing pain which is so disabling in some of these patients. Neurotization procedures are effective in res ... Link to item Cite

FDG-PET in the selection of brain lesions for biopsy.

Journal Article J Comput Assist Tomogr · 1991 The CT-guided stereotaxic needle biopsy has become a widely used procedure in the diagnostic evaluation of intracranial lesions including tumors. Conventional CT or MR frequently defines the anatomic regions of abnormality, which may be multiple lesions or ... Full text Link to item Cite

Choroidal lesions in patients with AIDS.

Journal Article Br J Ophthalmol · October 1990 Seven cases of bilateral, scattered, yellow-white choroidal lesions have been seen in AIDS patients since January 1988. One resulted from presumed extension of cryptococcal meningitis into the optic nerve and choroid. All the remaining six patients had pne ... Full text Link to item Cite

MR imaging in patients with temporal lobe seizures: correlation of results with pathologic findings.

Journal Article AJR Am J Roentgenol · September 1990 Thirty-nine consecutive patients with medically intractable complex partial seizures were studied with electroencephalography and MR imaging to localize an epileptogenic focus for temporal lobectomy. The patients were divided into three groups on the basis ... Full text Link to item Cite

Repair of isolated axillary nerve lesions after infraclavicular brachial plexus injuries: case reports.

Journal Article Neurosurgery · September 1990 Stretch injuries of the infraclavicular brachial plexus have a much better prognosis for spontaneous recovery than do their supraclavicular counterparts. We present three patients with stretch injuries of the infraclavicular brachial plexus who had spontan ... Full text Link to item Cite

Catecholaminergic innervation of the hippocampus in the cynomolgus monkey.

Journal Article J Comp Neurol · August 8, 1990 We studied the immunocytochemical distribution of catecholaminergic fibers in the hippocampal formation from two cynomolgus monkeys by using phenylethanolamine-N-methyltransferase, dopamine-beta-hydroxylase, and tyrosine-hydroxylase antibodies. There were ... Full text Link to item Cite

The identification of adrenergic receptors in human pial membranes.

Journal Article Neurosurgery · July 1990 Recent experimental work has suggested that the adrenergic nervous system is important in regulating cerebral blood flow under conditions of hypoxia and systemic arterial hypertension. Although previous investigations have demonstrated the presence of adre ... Full text Link to item Cite

An NMDA-mediated component of excitatory synaptic input to dentate granule cells in 'epileptic' human hippocampus studied in vitro.

Journal Article Brain Res · May 7, 1990 Recordings were made from human hippocampal tissue surgically removed for treatment of epilepsy. In 70% of cases, an N-methyl-D-aspartate (NMDA) receptor-mediated component was present in excitatory synaptic input to gyrus dentatus. NMDA receptors are norm ... Full text Link to item Cite

Anterior temporal lobectomy for complex partial seizures: evaluation, results, and long-term follow-up in 100 cases.

Journal Article Neurology · March 1990 We report evaluation and results in 100 patients who had undergone anterior temporal lobectomy for intractable complex partial seizures. Average follow-up was 9.0 years (range, 2 to 21 years). In the 2nd postoperative year, 63% were seizure free, 16% were ... Full text Link to item Cite

Dorsal root entry zone lesions for the treatment of post brachial avulsion injury pain.

Chapter · 1990 Cite

Nerve transposition for the restoration of elbow flexion following brachial plexus avulsion injuries.

Journal Article J Neurosurg · January 1990 Despite technical advances, the ability to restore motor function following a brachial plexus avulsion is limited. Twenty patients who suffered the loss of elbow flexion following a brachial plexus avulsion injury underwent a neurotization procedure in an ... Full text Link to item Cite

MR imaging in patients with temporal lobe seizures: correlation of results with pathologic findings.

Journal Article AJNR Am J Neuroradiol · 1990 Thirty-nine consecutive patients with medically intractable complex partial seizures were studied with electroencephalography and MR imaging to localize an epileptogenic focus for temporal lobectomy. The patients were divided into three groups on the basis ... Link to item Cite

Ocular toxoplasmosis in AIDS patients.

Journal Article Trans Am Ophthalmol Soc · 1990 We describe 16 cases of ocular and, in some patients, associated CNS toxoplasmosis in AIDS patients. T gondii is commonly associated with infection in the immunocompromised host. The lesions are most often seen in the CNS and eyes; involvement in the brain ... Link to item Cite

Retinal dysfunction as an initial ophthalmic sign in AIDS.

Journal Article Br J Ophthalmol · January 1990 Three cases of patients with AIDS in whom severe retinal dysfunction preceded the development of widespread funduscopic abnormalities are presented. The disparity between the minimal extent of visible retinal lesions and the severe loss of retinal function ... Full text Link to item Cite

Letter to the editor

Journal Article Surgical Neurology · January 1, 1990 Full text Cite

Cytomegalovirus retinitis.

Journal Article JAMA · December 15, 1989 Link to item Cite

Endogenous Klebsiella endophthalmitis: case report.

Journal Article Mt Sinai J Med · September 1989 A case of endogenous Klebsiella pneumoniae endophthalmitis, cryptogenic in origin, is presented. It was treated initially with success, only to recur three months later with loss of the eye. Common sites of Klebsiella infection are reviewed. This organism ... Link to item Cite

Chemotherapy in the management of intraocular lymphoma.

Journal Article Cancer · May 15, 1989 Six patients with intraocular (vitreous) lymphomas were treated with high-dose intravenous cytosine arabinoside (Ara-C). Four patients were previously untreated, one patient had previously received ocular and central nervous system radiation therapy and re ... Full text Link to item Cite

Ten-year experience with primary ocular 'reticulum cell sarcoma' (large cell non-Hodgkin's lymphoma).

Journal Article Br J Ophthalmol · May 1989 Fourteen patients with intraocular 'reticulum cell sarcoma' (non-Hodgkin's large cell lymphoma) ranging in age from 27 to 77 are presented. All patients had evidence of vitritis with 50% showing intraretinal and/or subretinal lesions and 21% having anterio ... Full text Link to item Cite

Neurofibromatosis and neural crest neoplasms: primary acquired melanosis and malignant melanoma of the conjunctiva.

Journal Article Surv Ophthalmol · 1989 With an occurrence of approximately 1 in 3000 births, von Recklinghausen neurofibromatosis (NF) is one of the most common inherited human disorders. NF is considered a neurocristopathy, a disorder of neural crest derived cells. One of the complications of ... Full text Link to item Cite

The status of dorsal root entry zone lesions in 1987.

Journal Article Clin Neurosurg · 1989 Link to item Cite

Comparison of [125I]HIPDm and [125I]iodoantipyrine in quantifying regional cerebral blood flow in rats.

Journal Article Stroke · November 1988 We determined regional cerebral blood flow (rCBF) using [125I]HIPDm [N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamin e] and [125I]iodoantipyrine autoradiography under control and pathologic conditions (hypercapnia [acidosis], hypoca ... Full text Link to item Cite

Unusual chorioretinal degeneration associated with sarcoidosis.

Journal Article Am J Ophthalmol · October 15, 1988 Full text Link to item Cite

Successful treatment of cryptococcal ventriculoatrial shunt infection with systemic therapy alone.

Journal Article Neurosurgery · September 1988 We report successful treatment of a cryptococcal ventriculoatrial shunt infection with antifungal therapy without shunt removal. ... Full text Link to item Cite

Multiple dosing of prostaglandin F2 alpha or epinephrine on cynomolgus monkey eyes. III. Histopathology.

Journal Article Invest Ophthalmol Vis Sci · September 1988 Prostaglandins (PGs), or their derivatives, are potent ocular hypotensive agents which may prove useful in glaucoma therapy. PGF2 alpha (250 micrograms in 50 microliter saline) or epinephrine 2% solution (50 microliter) was topically applied twice daily fo ... Link to item Cite

Tear urea nitrogen and creatinine levels in renal patients.

Journal Article Acta Ophthalmol (Copenh) · August 1988 Tear and blood urea nitrogen, creatinine, and glucose levels were quantitatively analyzed by an enzymatic method in 30 normal patients and in 10 patients with end stage renal disease. The tear and blood samples collected from the end stage renal patients b ... Full text Link to item Cite

N-3-pyridylmethyl-N'-p-nitrophenylurea ocular toxicity in man and rabbits.

Journal Article Br J Ophthalmol · August 1988 Ingestion of the rat poison N-3-pyridylmethyl-N'-p-nitrophenylurea (PNU) produced ocular toxicity in three humans and in an animal model, the Dutch Belted rabbit. The electroretinogram b wave was especially susceptible to the effects of the rodenticide, an ... Full text Link to item Cite

Intracranial atherosclerosis following radiotherapy.

Journal Article Neurology · July 1988 We describe a case of severe intracranial atherosclerosis in a young man who had received therapeutic radiation for a presumed brain neoplasm. Since there was no evidence of vascular disease outside the radiation ports, we speculate that accelerated athero ... Full text Link to item Cite

Active cytomegalovirus particles in the eyes of an AIDS patient being treated with 9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine (Ganciclovir).

Journal Article Br J Ophthalmol · April 1988 The eyes of an AIDS patient with cytomegalovirus (CMV) retinitis and pneumonitis who died while receiving maintenance therapy with the antiviral agent 9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine (Ganciclovir) were obtained for pathological examina ... Full text Link to item Cite

A clinical and histopathological review of intermediate uveitis ("pars planitis").

Journal Article Bull N Y Acad Med · March 1988 Link to item Cite

Dorsal root entry zone lesions for the treatment of brachial plexus avulsion injuries: a follow-up study.

Journal Article Neurosurgery · February 1988 Dorsal root entry zone (DREZ) lesions have been shown to yield short term relief from the pain associated with a brachial plexus avulsion injury. Because of the propensity of pain to recur after neuroablative procedures, 39 patients with pain after a brach ... Full text Link to item Cite

A clinical and histopathological review of intermediate uveitis ('pars planitis')

Journal Article Bulletin of the New York Academy of Medicine: Journal of Urban Health · January 1, 1988 Pars planitis with anterior and posterior ocular findings, without any clear systemic disease associations, continues as an enigma in the spectrum of uveitis and retino-choroiditis. In the course of pars planitis, a peculiar unwinding of subacute and chron ... Cite

Microangiopathic retinopathy in experimental diabetic monkeys.

Journal Article Trans Am Ophthalmol Soc · 1988 Link to item Cite

Localized injections of botulinum toxin for the treatment of focal dystonia and hemifacial spasm.

Journal Article Adv Neurol · 1988 Link to item Cite

Dorsal root entry zone lesions in the treatment of pain following brachial plexus avulsion, spinal cord injury and herpes zoster.

Journal Article Appl Neurophysiol · 1988 This paper details the long-term results in patients treated with dorsal root entry zone (DREZ) lesions for the treatment of pain following brachial plexus avulsion, spinal cord injury, and herpes zoster. With our current operative technique, 82% of patien ... Full text Link to item Cite

MR imaging of thoracic extradural arachnoid cysts.

Journal Article J Comput Assist Tomogr · 1988 Two extradural arachnoid cysts of the thoracic spine were studied with magnetic resonance imaging, myelography, and CT. Magnetic resonance imaging correctly characterized the extradural location of the cysts as well as the cyst contents as CSF, thus establ ... Full text Link to item Cite

Succinylcholine: a depolarizing relaxant.

Journal Article Am J Dis Child · December 1987 Full text Link to item Cite

Intracranial aneurysms for the primary care physician.

Journal Article N C Med J · November 1987 Link to item Cite

Prevalence, pathophysiology, and treatment of rhegmatogenous retinal detachment in treated cytomegalovirus retinitis.

Journal Article Am J Ophthalmol · September 15, 1987 Full text Link to item Cite

A case of Ollier's disease associated with two intracranial gliomas.

Journal Article Neurosurgery · September 1987 Ollier's disease or multiple enchondromatosis is a deforming dysplastic disease of cartilage involving primarily the metaphyses and diaphyses of long bones. It is only rarely associated with sarcomatous degeneration of the enchondromas or other generalized ... Full text Link to item Cite

Combined short- and long-term therapy for the treatment of cytomegalovirus retinitis using ganciclovir (BW B759U).

Journal Article Ophthalmology · July 1987 A total of 66 eyes in 41 patients were treated for cytomegalovirus (CMV) retinitis with a new acyclic nucleoside, ganciclovir (BW B759U). At the completion of the short-term therapy period of 21 days, 87.7% of eyes had stabilized or improved. Seventy-two p ... Full text Link to item Cite

Conus medullaris nerve root avulsions.

Journal Article J Neurosurg · June 1987 The association of avulsive lesions and pain has been well established in avulsions of the brachial plexus from the cervical spinal cord, but avulsive lesions of the conus medullaris have not previously been recognized or documented by direct observation. ... Full text Link to item Cite

Sexually transmitted ocular disorders associated with male homosexuality.

Journal Article Mt Sinai J Med · February 1987 Link to item Cite

Craniotomy flap osteomyelitis: a diagnostic approach.

Journal Article J Neurosurg · January 1987 Nine cases of suspected craniotomy flap osteomyelitis evaluated by combined bone and gallium scanning are presented. In six cases, the clinical data were inconclusive and evaluation by radionuclide imaging provided an accurate negative diagnosis. The other ... Full text Link to item Cite

Acquired immunodeficiency syndrome (AIDS).

Journal Article Surv Ophthalmol · 1987 The Acquired Immunodeficiency Syndrome (AIDS), caused by the human immunodeficiency virus (HIV), also called the human T-lymphotropic virus type III/lymphadenopathy-associated virus [HTLV-III/LAV], has affected over 23,000 people; more than half of those w ... Full text Link to item Cite

Viral particles in the conjunctiva of a patient with the acquired immune deficiency syndrome.

Journal Article Am J Med · January 1987 Conjunctival biopsy from a 39-year-old man with the acquired immune deficiency syndrome revealed the presence of herpes virus particles by electron microscopy. The finding of herpes virus particles in the conjunctiva may be of prognostic significance in do ... Full text Link to item Cite

Coats' disease in a renal transplant recipient.

Journal Article Nephrol Dial Transplant · 1987 We report the first case, to our knowledge, of Coats' disease, an idiopathic exudative retinopathy, in a renal transplant recipient. Due to certain similarities in clinical presentation and confounding factors present in patients who have received kidney a ... Link to item Cite

DREZ lesions for relief of pain related to spinal cord injury.

Journal Article J Neurosurg · October 1986 Fifty-six patients with intractable pain following a spinal cord injury were treated with dorsal root entry zone (DREZ) lesions. After a follow-up period ranging from 6 months to 6 years, 50% of patients had good pain relief. Certain pain syndromes tended ... Full text Link to item Cite

Eosinophil chemotaxis and anterior uveitis from topical dimaprit and nordimaprit.

Journal Article Invest Ophthalmol Vis Sci · October 1986 Topical application of the H2-histamine receptor agonist, dimaprit (S-[4-N,N-dimethylaminopropyl]isothiourea), produced eosinophil chemotaxis into the anterior segment of rabbit eyes only when an H2-antagonist was co-administered. Nordimaprit (S-[4-N,N-dim ... Link to item Cite

Ocular involvement in congenital leukemia.

Journal Article Am J Ophthalmol · June 15, 1986 Congenital leukemia, a rare disease with distinct features, was diagnosed in a 5-week-old girl. The infant was tachypneic and tachycardic, with intercostal retractions, distended abdomen, and multiple hematomas. Despite aggressive treatment, the child died ... Full text Link to item Cite

Syringomyelia in a man with sarcoidosis.

Journal Article Neurosurgery · June 1986 Sarcoidosis, generally a systemic ailment, uncommonly affects the central nervous system. It only rarely affects the spinal cord alone or in combination with other areas. Syringomyelia has never been associated with sarcoidosis. We report the case of a 32- ... Full text Link to item Cite

Posterior fossa arteriovenous malformations.

Journal Article J Neurosurg · January 1986 The authors report their treatment of 66 infratentorial arteriovenous malformations (AVM's) in patients aged 5 to 69 years. Sixty-one of them presented with hemorrhage, three with headache, and two with focal neurological deficits. Five patients underwent ... Full text Link to item Cite

Subtle cord magnetic resonance changes in cervical myelomalacia.

Journal Article Acta Radiol Suppl · 1986 After spinal cord injury cystic lesions of different types are known to develop. However, in a large group of patients radiologic examinations have not revealed abnormalities in spite of neurologic deficit symptoms. Magnetic resonance imaging in 6 such pat ... Link to item Cite

Localized conjunctival amyloidosis: case reports and review of literature.

Journal Article Ophthalmologica · 1986 Two men in their 20s had flat, stable, pink, well-vascularized conjunctival lesions found unexpectedly which on biopsy proved to be primary localized amyloidosis. The diagnosis was made possible by the absence of systemic manifestations or antecedent ocula ... Full text Link to item Cite

Senior-Loken syndrome (familial renal-retinal dystrophy) and Coats' disease.

Journal Article Am J Ophthalmol · December 15, 1985 Senior-Loken syndrome is a rare hereditary disease that combines a disorder resembling familial juvenile nephronophthisis with retinitis pigmentosa. Retinitis pigmentosa is even less frequently associated with exudative retinopathy. The patient, a 15-year- ... Full text Link to item Cite

Foreign body reaction to rubber Torkildsen catheters: a report of two cases.

Journal Article Neurosurgery · November 1985 Two patients came to clinical attention because of foreign body reactions to rubber catheters. In one patient, the reaction presented as multiple levels of aseptic meningitis and, in the second patient, the reaction caused an intracranial mass with localiz ... Full text Link to item Cite

Nursing revisited: profile Alice Howell Friedman. Interview by Ann Sheridan.

Journal Article Mass Nurse · March 1985 Link to item Cite

Choroidal (subretinal) neovascularization secondary to choroidal nevus and successful treatment with argon laser photocoagulation. Case reports and review of literature.

Journal Article Ophthalmologica · 1985 Retinal detachment secondary to choroidal nevus may be caused by subretinal fluid accumulation or neovascularization. Foveal subretinal fluid or leakage of choroidal neovascularization may impair visual acuity. 10 cases of nevus with serous sensory retinal ... Full text Link to item Cite

Dorsal root entry zone lesions for the treatment of postherpetic neuralgia.

Journal Article Neurosurgery · December 1984 These investigators attempted to diminish postherpetic neuralgia in 17 patients by making dorsal root entry zone (DREZ) lesions. They describe the clinical syndrome of pain after herpes zoster, the incidence of which increases with age, and discuss its pat ... Full text Link to item Cite

Failed aneurysm surgery. Reoperation in 115 cases.

Journal Article J Neurosurg · November 1984 Failure to obliterate intracranial aneurysms completely during initial surgery still occurs in spite of recent technical advances. Of the 115 reoperations reported in this series, 89% of the aneurysms were obliterated, and 84% of the patients had a satisfa ... Full text Link to item Cite

Ocular manifestations of hematologic disorders.

Journal Article Hosp Pract (Off Ed) · November 1984 Full text Link to item Cite

Dorsal root entry zone lesions for the treatment of post-herpetic neuralgia.

Journal Article J Neurosurg · June 1984 Post-herpetic pain was treated in 12 patients using dorsal root entry zone ( DREZ ) lesions. All patients had failed to receive adequate pain relief from conservative therapy consisting of transcutaneous nerve stimulation, carbamazepine, and/or amitriptyli ... Full text Link to item Cite

Correlation of serum tumor markers in advanced germ cell tumors with responses to chemotherapy and surgery.

Journal Article Cancer · March 15, 1984 Remission rates induced by chemotherapy alone or by combined chemotherapy and surgery were analyzed in relation to specific serum tumor marker abnormalities immediately before treatment in 103 patients with Stage III or bulky Stage II nonseminomatous germ ... Full text Link to item Cite

Drug reservoirs in topical therapy.

Journal Article Invest Ophthalmol Vis Sci · March 1984 The nictitating membrane, corneal epithelium, and corneal stroma were investigated as drug reservoirs. A hydrophilic drug, D,L-epinephrine HCl, or a lipophilic drug, chloramphenicol, was applied topically to rabbit eyes. Tissue levels of radioactive drug-p ... Link to item Cite

Subarachnoid hemorrhage from intracranial dissecting aneurysm.

Journal Article J Neurosurg · February 1984 Rupture of an intracranial dissecting aneurysm is a rare but dangerous event. The authors' experience with 14 cases of these lesions on the vertebrobasilar circulation suggests that these aneurysms have typical angiographic silhouettes and that, at least i ... Full text Link to item Cite

Role of computed tomography in the radiological evaluation of painful radiculopathy after negative myelography: foraminal neural entrapment.

Journal Article Neurosurgery · February 1984 Thirty-five patients with an unremarkable or a negative water-soluble contrast myelogram and a diagnosis of foraminal neural entrapment made or more firmly established by computed tomography (CT) were detected in evaluating 950 patients presenting for myel ... Full text Link to item Cite

The importance of defining light parameters in chronobiological studies.

Journal Article Chronobiol Int · 1984 Full text Link to item Cite

The retinal lesions of the acquired immune deficiency syndrome.

Journal Article Trans Am Ophthalmol Soc · 1984 AIDS is a reliably diagnosed disease that is indicative of an underlying cellular immunodeficiency with no other cause for the disorder. To date over 2000 cases have been reported in North America and Europe and the number is rising. Patients fulfilling th ... Link to item Cite

Fibrosarcoma of the heart metastatic to the brain.

Journal Article Neurosurgery · September 1983 A right parietal lobe metastasis of a fibrosarcoma originating in the left atrium of the heart was resected twice in a 33-year-old man. Light microscopy showed lightly packed, pleomorphic spindle cells with abundant collagen production and an alcian blue-p ... Full text Link to item Cite

Recurrent subacute thyroiditis: a report of three cases.

Journal Article N Y State J Med · June 1983 Link to item Cite

Cytomegalovirus retinitis: a manifestation of the acquired immune deficiency syndrome (AIDS).

Journal Article Br J Ophthalmol · June 1983 Two homosexual males with the "gay bowel syndrome' experienced an acute unilateral loss of vision. Both patients had white intraretinal lesions, which became confluent. One of the cases had a depressed cell-mediated immunity; both patients ultimately died ... Full text Link to item Cite

Head injuries. Initial evaluation and management.

Journal Article Postgrad Med · March 1983 While primary neurologic damage in the patient with head trauma may be irreversible, damage from secondary injuries can often be avoided with rapid identification and correction of factors potentially leading to such injury. In patients with severe injurie ... Full text Link to item Cite

An unusual presentation of isolated optic nerve sarcoidosis.

Journal Article J Clin Neuroophthalmol · March 1983 A 32-year old diabetic female had unilateral reduced vision (20/30) in an eye having the ophthalmoscopic appearance of papillophlebitis of the optic nerve head. After an apparently benign course, with recovery, the optic disc became edematous again and a c ... Link to item Cite

Treatment of acute lymphoblastic leukemia in adults: Results of the L-10 and L-10M protocols

Journal Article Journal of Clinical Oncology · January 1, 1983 Full text Cite

Retinal manifestations of the acquired immune deficiency syndrome (AIDS): cytomegalovirus, candida albicans, cryptococcus, toxoplasmosis and Pneumocystis carinii.

Journal Article Trans Ophthalmol Soc U K (1962) · 1983 The ocular manifestations of 34 patients with the Acquired Immune Deficiency Syndrome (AIDS), are reviewed. Cytomegalovirus retinitis was seen in 18 patients, cotton wool spots were observed in 11 patients with Pneumocystis carinii pneumonia; Fungal retini ... Link to item Cite

Topical conjunctival corticosteroid therapy for malignant atrophic papulosis (Kohlmeier-Degos disease).

Journal Article Mt Sinai J Med · 1983 Link to item Cite

Ocular effects in acquired immune deficiency syndrome.

Journal Article Mt Sinai J Med · 1983 Link to item Cite

Characteristics of adrenergic receptors in human pial arterioles

Journal Article Surgical Forum · January 1, 1983 Cite

Anatomic applications of xenon-enhanced CT scanning: visual image analysis and brain-blood partition coefficient studies in man.

Journal Article AJNR Am J Neuroradiol · 1983 The inhalation of nonradioactive xenon, an inert gas that diffuses freely across the blood-brain barrier, resulted in brain enhancement which was quantitated and visualized by computed tomography (CT). Serial CT scans obtained during the buildup and equili ... Link to item Cite

In vivo quantitation of regional cerebral blood flow in glioma and cerebral infarction: validation of the HIPDm-SPECT method.

Journal Article AJNR Am J Neuroradiol · 1983 Iodine-123 labeled hydroxyiodopropyldiamine (HIPDm) is a diffusible indicator with an 85%-90% extraction fraction and stable retention in the brain for more than 2 hr. Equilibrium-phase imaging and quantitation using single-photon emission computed tomogra ... Link to item Cite

Experience using two CT-guided stereotactic biopsy methods.

Journal Article Appl Neurophysiol · 1983 15 patients had intracranial CT-guided stereotactic biopsies. Biopsies were performed either with a Riechert-Mundinger stereotactic frame modified for use in the CT or by using the CT scan to establish the relationship of the intracranial lesion to identif ... Full text Link to item Cite

Subretinal neovascularisation in ocular toxoplasmosis.

Journal Article Br J Ophthalmol · August 1982 Full text Link to item Cite

Pituitary adenoma presenting as facial pain: report of two cases and review of the literature.

Journal Article Neurosurgery · June 1982 Full text Link to item Cite

Cytomegalovirus retinitis and immunodeficiency in homosexual males.

Journal Article Lancet · April 24, 1982 Full text Link to item Cite

Large dominant hemisphere AVMs near the speech area: Treatment with intrasvascular glue in two patients

Journal Article Neurosurgery · January 1, 1982 Cite

Measurement of regional cerebral blood flow using hydroxyiodopropyldiamine and single photon emission tomography

Journal Article Neurosurgery · January 1, 1982 Cite

Ultrastructure of the eye in fetal type II glycogenosis (Pompe's disease).

Journal Article Invest Ophthalmol Vis Sci · January 1982 Type II glycogenosis is an autosomal recessive storage disease characterized by absence of the enzyme acid alpha-1,4-glucosidase. The eye of a 16 week fetus, aborted after diagnosis by amniocentesis, was studied by light and electron microscopy. Extensive ... Link to item Cite

Ocular pathology of Fabry's disease in a hemizygous male following renal transplantation.

Journal Article Surv Ophthalmol · 1982 The ocular pathology of a hemizygous male with Fabry's disease after renal transplantation is reported. The ocular pathology in this patient was essentially identical to that which has previously been reported for both hemizygotes and heterozygotes afflict ... Full text Link to item Cite

Electrical stimulation of the conus medullaris to control bladder emptying in paraplegia: a ten-year review.

Journal Article Appl Neurophysiol · 1982 Full text Link to item Cite

Case report. Steroid exophthalmos.

Journal Article J Comput Assist Tomogr · December 1981 Full text Link to item Cite

Proton-beam irradiated epithelioid cell melanoma of the ciliary body.

Journal Article Ophthalmology · December 1981 A malignant ciliary body melanoma received proton-beam irradiation. After an apparent failure of the tumor to respond, the eye was enucleated. A predominantly epithelioid cell tumor appeared viable by light microscopy, and a low degree of mitotic activity ... Full text Link to item Cite

Sugiura's sign. Perilimbal vitiligo in the Vogt-Koyanagi-Harada syndrome.

Journal Article Ophthalmology · November 1981 Link to item Cite

Erosion of the orbital plate (frontal bone) by a benign tumor of the lacrimal gland.

Journal Article Ophthalmic Surg · October 1981 Link to item Cite

On angiomas of retina, brain, and skin.

Journal Article Pediatrics · May 1981 Link to item Cite

The isolated perfused frog eye: a useful preparation for the investigation of drug effects on retinal function.

Journal Article J Pharmacol Methods · May 1981 The isolated frog eye perfused through its ophthalmic artery with a modified oxygenated Sickel's media responds to light stimuli of different wavelengths in a manner similar to that observed in the frog eye in vivo for periods of 9 hr and longer. Short- an ... Full text Link to item Cite

The significance of splenomegaly in 101 adults with acute lymphoblastic leukemia (ALL) at presentation and during remission.

Journal Article Blood · April 1981 One-hundred-one adult patients with ALL were analyzed to determine the prognostic implications of splenomegaly occurring at any time during the course of their illness. The clinical status of the spleen at presentation was not found to be of major prognost ... Link to item Cite

Ocular manifestations of multiple myeloma, Waldenström's macroglobulinemia and benign monoclonal gammopathy.

Journal Article Surv Ophthalmol · 1981 Multiple myeloma, Waldenström's macroglobulinemia and benign monoclonal gammopathy are examples of diseases in which there is an uncontrolled proliferation of cells involved in antibody synthesis. Myeloma and macroglobulinemia are considered malignant dise ... Full text Link to item Cite

Electrical stimulation of the conus medullaris to control the bladder in the paraplegic patient. A 10-year review.

Journal Article Appl Neurophysiol · 1981 Full text Link to item Cite

Marginal corneal ulceration (limbal guttering) as a presenting sign of temporal arteritis.

Journal Article Ophthalmology · November 1980 A 68-year-old white woman was seen because of pain in each eye associated with the development of a marginal corneal ulceration (limbal guttering) bilaterally. Subsequently, the patient developed swelling over the bridge of the nose, painful necrotic lesio ... Full text Link to item Cite

Ocular reticulum cell sarcoma.

Journal Article Br J Ophthalmol · October 1980 Although rare, ocular reticulum cell sarcoma presents a recognisable clinical pattern, as confirmed by 3 new cases. Typical patients, in their sixth and seventh decades, initially complain of gradual visual loss. Examination reveals 'uveitis' with prominen ... Full text Link to item Cite

Immunofluorescent studies of the eye in Waldenström's macroglobulinemia.

Journal Article Arch Ophthalmol · April 1980 The eyes of a 53-year-old woman with K light chain macroglobulinemia were studied histopathologically. Retinal hemorrhages were observed on gross examination. Microscopic examination disclosed eosinophilic, PAS-positive deposits in cystoid spaces within th ... Full text Link to item Cite

Removal of intravitreous cysticerci from the surface of the optic nervehead. A pars plana approach.

Journal Article Arch Ophthalmol · April 1980 Two larvae of Taenia solium (eg, Cysticercus cellulosae) were identified in the posterior vitreous attached to the optic nervehead of a 13-year-old Guatemalan girl. Preoperative evaluation showed the larvae to be viable. The vitreous showed a mild cellular ... Full text Link to item Cite

Tuberculoma of the choroid.

Journal Article Ophthalmology · March 1980 A 22-year-old South American man with known active pulmonary tuberculosis was seen because of marked unilateral loss of vision. A diagnosis of choroidal tuberculoma was made. Resolution of the lesion while under antituberculous medication was documented by ... Full text Link to item Cite

Identification and characterization of adrenergic receptors and catecholamine-stimulated adenylate cyclase in hog pial membranes.

Journal Article Brain Res · February 3, 1980 In order to define the adrenergic receptors in small pial blood vessels, we studied [3H]dihydroalprenolol (DHA) binding, [3H]dihydroergocryptine (DHE) binding, and catecholamine-stimulated adenylate cyclase in membranes prepared from the hog pia. [3H]dha b ... Full text Link to item Cite

Echocardiography in acute myocardial infarction

Journal Article Practical Cardiology · January 1, 1980 Cite

Electron microscopic observations of intravitreal Cysticercus cellulosae (Taenia solium).

Journal Article Ophthalmologica · 1980 Cysticercus cellulosae, the larval stage of Taenia solium, was studied by light and electron microscopy after its removal from the vitreous. The ultrastructure of the larva is highly organized and displays a superficial tegument and deeper parenchyma. The ... Full text Link to item Cite

Senile macular degeneration: clinical, histopathological, and ultrastructural studies.

Journal Article Mt Sinai J Med · 1980 Link to item Cite

Transient open-angle glaucoma associated with sickle cell trait: report of 4 cases.

Journal Article Br J Ophthalmol · December 1979 Four black patients, all with sickle trait (SA), developed transient open-angle glaucoma with blood in Schlemm's canal. In 3 patients the condition followed blunt trauma, while in the fourth no antecedent trauma was described. The intraocular pressure beca ... Full text Link to item Cite

New findings in the chromosome 13 long-arm deletion syndrome and retinoblastoma.

Journal Article Ophthalmology · June 1979 New clinical and pathologic findings in patients with deletion of the long arm of chromosome 13 (13q-) include optic nerve hypoplasia and retinal dysplasia. Fibroblasts derived from patients with a 13q- syndrome with and without retinoblastoma, as well as ... Full text Link to item Cite

Clinicopathological correlations in unilateral glaucoma.

Journal Article Bull N Y Acad Med · March 1979 Link to item Cite

Asymptomatic transient uveitis in children with inflammatory bowel disease.

Journal Article Am J Dis Child · February 1979 Although acute anterior uveitis has been noted in children with inflammatory bowel disease, it has not been appreciated in the absence of ocular symptoms. To determine the presence of asymptomatic uveitis, slit-lamp examinations were performed in 19 childr ... Full text Link to item Cite

Discussion of Three Papers

Journal Article Ophthalmology · January 1, 1979 Full text Cite

Effect of photoperiod reversal on twenty-four hour patterns for dopamine levels in the corpus striatum and upper and lower brainstem of the rat.

Journal Article Int J Chronobiol · 1979 Dopamine levels were measured in the corpus striatum, upper and lower brainstem at 6 hour intervals for a period of 24 hours in rats adapted for 3 weeks to either of two concomitantly-conducted lighting programs. On the normal cycle the animals were illumi ... Link to item Cite

Adrenergic receptors of small cerebral blood vessels

Journal Article Stroke · January 1, 1979 Cite

Diurnal variations in the toxicity and tissue levels of spermidine in mice.

Journal Article Life Sci · November 20, 1978 Full text Link to item Cite

Ocular penetration of 5-fluorocytosine.

Journal Article Invest Ophthalmol Vis Sci · July 1978 Ocular penetration of 5-fluorocytosine (5FC) was studied in uninfected rabbits after subconjunctival and oral administration. With oral administration, 5FC achieved therapeutic levels in both the vitreous and aqueous humors. The use of a pharmacokinetic mo ... Link to item Cite

GABA, picrotoxin and retinal sensitivity.

Journal Article Brain Res · June 16, 1978 Full text Link to item Cite

A histopathologic study of retinal arterial aneurysms.

Journal Article Am J Ophthalmol · April 1978 An isolated retinal arterial aneurysm was found postmortem in the eye of a 75-year-old hypertensive woman, and multiple aneurysms were in the enucleated eye of a 68-year-old hypertensive man with neovascular glaucoma. The aneurysmal sites showed thickening ... Full text Link to item Cite

Positive after-image, PAI: early erasure by saccadic eye movement or Jendrassik manoeuvre.

Journal Article Experientia · January 15, 1978 Positive after-images (PAIs) evoked by low intensity stroboscopic flash are erased by voluntary large amplitude saccadic eye movements. The duration of the PAI is shortened by a Jendrassik manoeuvre. The results suggest that muscle spindle afferent impulse ... Full text Link to item Cite

Effect of photoperiod reversal on twenty-four hour patterns for GABA levels in rat brain.

Journal Article Int J Chronobiol · 1978 GABA levels were measured in various areas of rat brain at 3 or 6 hour intervals for a period of 24 hours in animals adapted for 3 weeks to a programmed-lighting schedule. On the normal cycle rats were illuminated from 08 to 20 hours; on the reverse cycle, ... Link to item Cite

Binding of [³H] dihydroalprenolol (DHA) and [³H] dihydroergocryptine (DHE) to hog brain pial blood vessels

Journal Article Federation Proceedings · January 1, 1978 Cite

The association of retinitis pigmentosa with preretinal macular gliosis.

Journal Article Br J Ophthalmol · September 1977 A retrospective study of the histopathological features of retinitis pigmentosa was undertaken. A consistent finding in 10 out of 10 eyes from 6 patients with retinitis pigmentosa was the presence of a preretinal membrane. The frequency of this finding has ... Full text Link to item Cite

The association of rubeosis iridis with endothelialisation of the anterior chamber: report of a clinical case with histopathological review of 16 additional cases.

Journal Article Br J Ophthalmol · April 1977 A patient is reported in whom the clinical observation of extension of the corneal endothelium and Descemet's membrane in association with rubeosis iridis was confirmed by histopathological examination. In a study of eyes which had been removed and demonst ... Full text Link to item Cite

Aqueous and vitreous levels of 5 fluorocytosine following subconjunctival and oral administration

Journal Article INVEST.OPHTHAL.VISUAL SCI. · January 1, 1977 Cite

Radical anterior segment surgery for epithelial invasion of the anterior chamber: report of three cases.

Journal Article Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol · 1977 Three patients who developed epithelial invasion of the anterior chamber were treated by radical anterior segment surgery. Two adults had typical epithelial downgrowth of the anterior chamber, while the third patient, an 8-year-old child, developed large s ... Link to item Cite

Drusen of the optic disc.

Journal Article Surv Ophthalmol · 1977 Although optic disc drusen have been of interest to ophthalmologists for more than 100 years, their etiology and many aspects of their relationship to other clinical conditions remain obscure. They have been clinically observed in 0.3% of the population, a ... Full text Link to item Cite

Chronopharmacology of strychnine and allylglycine in the mouse.

Journal Article Clin Exp Pharmacol Physiol · 1977 1. The response of individually caged mice to the lethal actions of allylglycine and strychnine was evaluated in animals previously conditioned on an LD 12:12 (12 h light-12 h darkness) schedule in a controlled environment. 2. These convulsant agents were ... Full text Link to item Cite

Squamous cell carcinoma of the conjunctiva. Value of exfoliative cytology in diagnosis.

Journal Article Surv Ophthalmol · 1977 Cytologic examination is of potential value to the practicing ophthalmologist in confirming the clinical impression of cancer of the eye. Scrapings of conjunctival lesions can be prepared in the office, stained with Giemsa stain and rapidly examined. Carci ... Full text Link to item Cite

Congenital alacrima.

Journal Article Surv Ophthalmol · 1977 A sixteen-year-old black male with congenital alacrima and deficient salivary secretion demonstrated evidence of keratoconjunctivitis sicca. The workup revealed elevated immunoglobulins and histologically normal lacrimal and salivary glands, but there was ... Full text Link to item Cite

Electrical stimulation of the conus medullaris in the paraplegic. A 5-year review.

Journal Article Appl Neurophysiol · 1977 In 1970 we carried out the first electrode implantation of the conus medullaris of a 17-year-old male paraplegic to control the emptying of his paralyzed bladder. Our patient has used electromicturition for 6 years to successfully empty his bladder and pre ... Full text Link to item Cite

The retina in type 5 hyperlipoproteinemia.

Journal Article Am J Ophthalmol · July 1976 Of two patients with type 5 hyperlipoproteinemia, one exhibited lipemia retinalis with multiple retinal hemorrhages and intraretinal lipid extravasations. Postmortem examination showed hemorrhages in the inner retinal layers and lipid deposits largely in t ... Full text Link to item Cite

Sclero-cornea and defective mesodermal migration.

Journal Article British Journal of Ophthalmology · November 1, 1975 A 5-month-old boy with bilateral sclero-cornea, multiple systemic abnormalities, and normal karyotype had his left eye removed after corneal perforation. Histopathological examination of the enucleated eye revealed an irregular corneal epithelium, absent B ... Cite

Metastatic carcinoma of the iris.

Journal Article Am J Ophthalmol · November 1975 Of three women and one man with metastatic carcinoma of the iris, the average age of the four was 50.2 years. Two of the tumors originated in the breast and two in the lungs. The average survival from time of diagnosis of the iris lesion was less than six ... Full text Link to item Cite

Sclero-cornea and defective mesodermal migration.

Journal Article Br J Ophthalmol · November 1975 A 5-month-old boy with bilateral sclero-cornea, multiple systemic abnormalities, and normal karyotype had his left eye removed after corneal perforation. Histopathological examination of the enucleated eye revealed an irregular corneal epithelium, absent B ... Full text Link to item Cite

Drusen of the optic disc. A retrospective study in cadaver eyes.

Journal Article Br J Ophthalmol · August 1975 A retrospective study of 737 consecutive necropsies yielded 15 cases of drusen of the optic nerve head, an incidence of 20-4 cases per thousand. This represents the highest incidence yet reported. The histopathological features of drusen of the nerve head ... Full text Link to item Cite

Controlled trial comparing co-trimoxazole and methenamine hippurate in the prevention of recurrent urinary tract infections.

Journal Article Med J Aust · May 10, 1975 To study the effects of continous low doses of antibacterial agents after eradication of bacteriuria in patients with recurrent urinary tract infection, 31 patients with documented recurrent urinary tract infection were allocated alternately to treatment w ... Link to item Cite

Drusen of the optic disc. A histopathological study.

Journal Article Trans Ophthalmol Soc U K (1962) · April 1975 A retrospective study of autopsy and surgically enucleated eyes yielded eighteen autopsy and four surgically enucleated eyes harbouring drusen of the optic disc. The average age of the patients in this series was 58-6 years. Various histopathological chang ... Link to item Cite

Ultrastructure and clinicopathologic correlation of idiopathic preretinal macular fibrosis.

Journal Article Am J Ophthalmol · March 1975 Detailed light and electron microscopic examination of early idiopathic preretinal fibrosis lesions showed that the fibrosis consisted of a layer of glial cells on the retinal surface. Two cases supported the clinical observation that a glinting retinal re ... Full text Link to item Cite

Exogenous Moraxella liquefaciens endophthalmitis.

Journal Article Ophthalmologica · 1975 Moraxella species have been generally associated with diseases of the external eye. In this report we present a case of exogenous Moraxella liquefaciens endothalmitis which developed 14 years after an intracapsular cataract extraction. ... Full text Link to item Cite

Uniocular vascular occlusion in a paraplegic hybrid monkey. A clinicopathologic study.

Journal Article J Med Primatol · 1975 One eye of a hybrid monkey showed ophthalmoscopic, fluorescein angiographic, and electroretinographic evidence of ophthalmic artery occlusive disease. Histopathologic examination of that eye revealed widespread atrophy of the choroid, retina and optic nerv ... Full text Link to item Cite

Gamma-butyrolactone sleep: A 24-hour rhythm paralleling normal sleep in the rat and CNS amine changes.

Journal Article Pharmacol Biochem Behav · 1975 The duration of sleep induced by a fixed dose of gamma-butyrolactone (GBL) (350 mg/kg, IP) FOllows the normal circadian sleep pattern of rats. GBL sleep duration is maximal at 1800 hr and minimal at 0600 hr. CNS amine changes are not extensive, but when no ... Full text Link to item Cite

Chemosis, proptosis and amaurosis in a 19-year-old male.

Journal Article Surv Ophthalmol · 1975 An ectopic pinealoma was excised in 1966 and the patient received radiotherapy postoperatively. The patient developed diabeted insipidus, hypopituitarism, chemosis, proptosis, and loss of vision in the left eye. The left eye was enucleated in 1974 and a la ... Full text Link to item Cite

Retinal pigment epithelial degeneration, partial retinal atrophy and macular hole in acute lymphocytic leukemia.

Journal Article Albrecht Von Graefes Arch Klin Exp Ophthalmol · 1975 A seven year old child with acute lymphocytic leukemia presented at autopsy with a macular hole, and degeneration of the retinal pigment epithelium and its overlying photoreceptors. She had been treated with cobalt 60, methotrexate, vincristine cyclophosph ... Full text Link to item Cite

Retinal oxalosis in two diabetic patients.

Journal Article Am J Ophthalmol · August 1974 Full text Link to item Cite

Unusual causes of episcleritis

Journal Article Transactions of the American Academy of Ophthalmology and Otolaryngology · January 1, 1974 A number of the collagen diseases may be associated with episcleral involvement. These include rheumatoid arthritis, polyarteritis nodosa, relapsing polychondritis, and systemic lupus erythematosus. Episcleral nodules have rarely been reported in temporal ... Cite