Harvey Jay Cohen

Journal Article J Geriatr Oncol · November 2024 INTRODUCTION: Among older adults without cancer, living alone is associated with poor health outcomes. However, among older adults with non-small cell lung cancer (NSCLC) who live alone, data on function, cognition, and quality of life (QOL) during systemi ... Full text Link to item Cite

"Faith and a sunny day": Association of patient frailty with strain experienced by informal caregivers of older adults with non-muscle-invasive bladder cancer.

Journal Article J Geriatr Oncol · November 2024 INTRODUCTION: Few studies have evaluated the potential effects of aging-related conditions like frailty in older adults with cancer on informal caregivers. Our objective was to evaluate the association between the sum total of the aging-related conditions ... Full text Link to item Cite

Black Americans With Sickle Cell Disease (SCD) Demonstrate Accelerated Epigenetic Pace of Aging Compared to Black Americans Without SCD.

Journal Article J Gerontol A Biol Sci Med Sci · November 1, 2024 BACKGROUND: Sickle cell disease (SCD) is a chronic medical condition characterized by red blood cell sickling, vaso-occlusion, hemolytic anemia, and subsequently, end-organ damage and reduced survival. Because of this significant pathophysiology and early ... Full text Link to item Cite

genRCT: a statistical analysis framework for generalizing RCT findings to real-world population.

Journal Article J Biopharm Stat · October 2024 When evaluating the real-world treatment effect, the analysis based on randomized clinical trials (RCTs) often introduces generalizability bias due to the difference in risk factors between the trial participants and the real-world patient population. This ... Full text Link to item Cite

Alzheimer disease-related biomarkers and cancer-related cognitive decline: the Thinking and Living with Cancer study.

Journal Article J Natl Cancer Inst · September 1, 2024 PURPOSE: We evaluated whether plasma Alzheimer disease (AD)-related biomarkers were associated with cancer-related cognitive decline among older breast cancer survivors. METHODS: We included survivors aged 60-90 years with primary stage 0-III breast cancer ... Full text Link to item Cite

Functional decline in older breast cancer survivors treated with and without chemotherapy and non-cancer controls: results from the Hurria Older PatiEnts (HOPE) prospective study.

Journal Article J Cancer Surviv · August 2024 PURPOSE: This study aimed to assess whether physical functional decline in older women with early-stage breast cancer is driven by cancer, chemotherapy, or a combination of both. METHODS: We prospectively sampled three groups of women aged ≥ 65: 444 with e ... Full text Link to item Cite

Palbociclib in adults aged 70 years and older with advanced breast cancer: A phase 2 multicenter trial (Alliance A171601).

Journal Article J Geriatr Oncol · July 2024 INTRODUCTION: Palbociclib is a widely used treatment for advanced breast cancer in older adults. However, the existing evidence regarding its safety and tolerability in this age group is inconsistent and limited to retrospective subgroup or pooled analyses ... Full text Link to item Cite

Vegetable Gardening and Health Outcomes in Older Cancer Survivors: A Randomized Clinical Trial.

Journal Article JAMA Netw Open · June 3, 2024 IMPORTANCE: Cancer survivors experience accelerated functional decline that threatens independence and quality of life. Previous studies have suggested that vegetable gardening may improve diet, physical activity, and physical function in this vulnerable p ... Full text Link to item Cite

Cognitive and Cerebrospinal Fluid Alzheimer's Disease-related Biomarker Trajectories in Older Surgical Patients and Matched Nonsurgical Controls.

Conference Anesthesiology · May 1, 2024 BACKGROUND: Anesthesia and/or surgery accelerate Alzheimer's disease pathology and cause memory deficits in animal models, yet there is a lack of prospective data comparing cerebrospinal fluid (CSF) Alzheimer's disease-related biomarker and cognitive traje ... Full text Link to item Cite

Falls prechemotherapy and toxicity-related hospitalization during adjuvant chemotherapy for breast cancer in older women: Results from the prospective multicenter HOPE trial.

Journal Article Cancer · March 15, 2024 BACKGROUND: Older women with breast cancer frequently experience toxicity-related hospitalizations during adjuvant chemotherapy. Although the geriatric assessment can identify those at risk, its use in clinic remains limited. One simple, low-cost marker of ... Full text Link to item Cite

Prediction of cognitive decline in older breast cancer survivors: the Thinking and Living with Cancer study.

Journal Article JNCI Cancer Spectr · February 29, 2024 PURPOSE: Cancer survivors commonly report cognitive declines after cancer therapy. Due to the complex etiology of cancer-related cognitive decline (CRCD), predicting who will be at risk of CRCD remains a clinical challenge. We developed a model to predict ... Full text Link to item Cite

Geriatric assessment-derived deficit accumulation and patient-reported treatment burden in older adults with bladder cancer.

Journal Article J Am Geriatr Soc · February 2024 BACKGROUND: When a person's workload of healthcare exceeds their resources, they experience treatment burden. At the intersection of cancer and aging, little is known about treatment burden. We evaluated the association between a geriatric assessment-deriv ... Full text Link to item Cite

How I treat anemia in older adults.

Journal Article Blood · January 18, 2024 With the global growing older adult population, clinicians face the common, yet complex challenge of how to evaluate and manage anemia in this population. Older age predisposes to common causes of anemia such as nutritional deficiencies, inflammatory disor ... Full text Link to item Cite

Anti-CMV IgG Seropositivity is Associated with Plasma Biomarker Evidence of Amyloid-β Accumulation.

Journal Article J Alzheimers Dis · 2024 BACKGROUND: Some human studies have identified infection with cytomegalovirus (CMV), a member of the alpha herpesvirus family, as a risk factor for Alzheimer's disease and related dementias (ADRD). To our knowledge, no studies have evaluated associations o ... Full text Link to item Cite

Biomarkers of erythropoiesis response to intravenous iron in a crossover pilot study in unexplained anemia of the elderly.

Journal Article Hematology · December 2023 Anemia is common in older adults, but often unexplained. Previously, we conducted a randomized, controlled trial of intravenous (IV) iron sucrose to study its impact on the 6-minute walk test and hemoglobin in older adults with unexplained anemia and ferri ... Full text Link to item Cite

Role of Blood-Brain Barrier Dysfunction in Delirium following Non-cardiac Surgery in Older Adults.

Journal Article Ann Neurol · December 2023 OBJECTIVE: Although animal models suggest a role for blood-brain barrier dysfunction in postoperative delirium-like behavior, its role in postoperative delirium and postoperative recovery in humans is unclear. Thus, we evaluated the role of blood-brain bar ... Full text Link to item Cite

Depressive symptom trajectories in older breast cancer survivors: the Thinking and Living with Cancer Study.

Journal Article J Cancer Surviv · November 4, 2023 PURPOSE: To identify trajectories of depressive symptoms in older breast cancer survivors and demographic, psychosocial, physical health, and cancer-related predictors of these trajectories. METHODS: Recently diagnosed nonmetastatic breast cancer survivors ... Full text Link to item Cite

Ageing and physical resilience after health stressors.

Journal Article Stress Health · September 2023 The objectives of this article are to introduce a conceptual framework for physical resilience in the context of ageing and to discuss key elements and challenges in the design of studies of physical resilience after health stressors. Advancing age is asso ... Full text Link to item Cite

Epigenetic aging in older breast cancer survivors and noncancer controls: preliminary findings from the Thinking and Living with Cancer Study.

Journal Article Cancer · September 1, 2023 BACKGROUND: Cancer and its treatments may accelerate aging in survivors; however, research has not examined epigenetic markers of aging in longer term breast cancer survivors. This study examined whether older breast cancer survivors showed greater epigene ... Full text Link to item Cite

Plasma levels of interleukin-6 mediate neurocognitive performance in older breast cancer survivors: The Thinking and Living With Cancer study.

Journal Article Cancer · August 1, 2023 BACKGROUND: Immune activation/inflammation markers (immune markers) were tested to explain differences in neurocognition among older breast cancer survivors versus noncancer controls. METHODS: Women >60 years old with primary breast cancer (stages 0-III) ( ... Full text Link to item Cite

Perioperative changes in neurocognitive and Alzheimer's disease-related cerebrospinal fluid biomarkers in older patients randomised to isoflurane or propofol for anaesthetic maintenance.

Journal Article Br J Anaesth · August 2023 BACKGROUND: Animal studies have shown that isoflurane and propofol have differential effects on Alzheimer's disease (AD) pathology and memory, although it is unclear whether this occurs in humans. METHODS: This was a nested randomised controlled trial with ... Full text Link to item Cite

The Aging-Cancer Cycle: Mechanisms and Opportunities for Intervention.

Journal Article The journals of gerontology. Series A, Biological sciences and medical sciences · July 2023 Aging is the largest risk factor for the development of cancer. A growing body of literature indicates that aging and cancer often play a somewhat reciprocal relationship at various times. On the one hand, aging is a "driver" of cancer, and on the other, c ... Full text Cite

Effect of Low-Dose Aspirin Versus Placebo on Incidence of Anemia in the Elderly : A Secondary Analysis of the Aspirin in Reducing Events in the Elderly Trial.

Journal Article Ann Intern Med · July 2023 BACKGROUND: Daily low-dose aspirin increases major bleeding; however, few studies have investigated its effect on iron deficiency and anemia. OBJECTIVE: To investigate the effect of low-dose aspirin on incident anemia, hemoglobin, and serum ferritin concen ... Full text Link to item Cite

Multimorbidity in patients with monoclonal gammopathy of undetermined significance.

Journal Article Int J Cancer · June 15, 2023 Monoclonal gammopathy of undetermined significance (MGUS), a precursor to multiple myeloma, is present in over 5% of adults aged 70 and older, a population with a high prevalence of multimorbidity. MGUS is often diagnosed incidentally when patients seek ca ... Full text Link to item Cite

A Role for Blood-brain Barrier Dysfunction in Delirium following Non-Cardiac Surgery in Older adults.

Journal Article medRxiv · May 10, 2023 OBJECTIVE: Although animal models suggest a role for blood-brain barrier dysfunction in postoperative delirium-like behavior, its role in postoperative delirium and postoperative recovery in humans is unclear. Thus, we evaluated the role of blood-brain bar ... Full text Link to item Cite

Toxicity risk score and clinical decline after adjuvant chemotherapy in older breast cancer survivors.

Journal Article J Natl Cancer Inst · May 8, 2023 BACKGROUND: Chemotoxicity risk scores were developed to predict grade 3-5 chemotherapy toxicity in older women with early breast cancer. However, whether these toxicity risk scores are associated with clinically meaningful decline in patient health remains ... Full text Link to item Cite

Corrigendum to 'Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study' (Br J Anaesth 2021; 127: 917-928).

Journal Article Br J Anaesth · May 2023 Full text Link to item Cite

Late-onset Cognitive Impairment and Modifiable Risk Factors in Adult Childhood Cancer Survivors.

Journal Article JAMA Netw Open · May 1, 2023 IMPORTANCE: Long-term survivors of childhood cancer may be at elevated risk for new neurocognitive impairment and decline as they age into adulthood. OBJECTIVE: To determine whether aging adult childhood cancer survivors report more new-onset neurocognitiv ... Full text Link to item Cite

Change in four measures of physical function among older adults during lung cancer treatment: A mixed methods cohort study.

Journal Article J Geriatr Oncol · March 2023 INTRODUCTION: Functional outcomes during non-small cell lung cancer (NSCLC) treatment are critically important to older adults. Yet, data on physical function and which measures best capture functional change remain limited. MATERIALS AND METHODS: This mul ... Full text Link to item Cite

Improving the Approach to Defining, Classifying, Reporting and Monitoring Adverse Events in Seriously Ill Older Adults: Recommendations from a Multi-stakeholder Convening.

Journal Article J Gen Intern Med · February 2023 BACKGROUND: Clinical trials are needed to study topics relevant to older adults with serious illness. Investigators conducting clinical trials with this population are challenged by how to appropriately define, classify, report, and monitor serious and non ... Full text Link to item Cite

Inflammation and Clinical Decline After Adjuvant Chemotherapy in Older Adults With Breast Cancer: Results From the Hurria Older Patients Prospective Study.

Journal Article J Clin Oncol · January 10, 2023 PURPOSE: Older breast cancer survivors are at increased risk of clinical decline after adjuvant chemotherapy. This study aimed to evaluate whether inflammatory markers assessed before adjuvant chemotherapy are associated with chemotherapy-induced clinical ... Full text Link to item Cite

Elevated C-Reactive Protein and Subsequent Patient-Reported Cognitive Problems in Older Breast Cancer Survivors: The Thinking and Living With Cancer Study.

Journal Article J Clin Oncol · January 10, 2023 PURPOSE: To examine longitudinal relationships between levels of C-reactive protein (CRP) and cognition in older breast cancer survivors and noncancer controls. METHODS: English-speaking women age ≥ 60 years, newly diagnosed with primary breast cancer (sta ... Full text Link to item Cite

Low-Intensity Adjuvant Chemotherapy for Breast Cancer in Older Women: Results From the Prospective Multicenter HOPE Trial.

Journal Article J Clin Oncol · January 10, 2023 PURPOSE: Older women with high-risk early breast cancer (EBC) benefit from adjuvant chemotherapy, but their treatment is frequently complicated by toxic side effects, resulting in dose reductions and delays. This makes it challenging for oncologists to mai ... Full text Link to item Cite

Resilience in older adults with cancer: A scoping literature review.

Journal Article J Geriatr Oncol · January 2023 INTRODUCTION: Resilience, the ability to respond to stressors by maintaining or rapidly returning to normal homeostasis, serves as a new paradigm to improve the care of older adults. However, resilience research in oncology is nascent. We aimed to describe ... Full text Link to item Cite

Tryptophan Metabolism and Neurodegeneration: Longitudinal Associations of Kynurenine Pathway Metabolites with Cognitive Performance and Plasma Alzheimer's Disease and Related Dementias Biomarkers in the Duke Physical Performance Across the LifeSpan Study.

Journal Article J Alzheimers Dis · 2023 BACKGROUND: The kynurenine pathway (KP) comprises a family of tryptophan-derived metabolites that some studies have reported are associated with poorer cognitive performance and an increased risk of Alzheimer's disease and related dementias (ADRD). OBJECTI ... Full text Open Access Link to item Cite

Abstract B111: Black-White differences in physical and cognitive aging among older breast cancer survivors in the Thinking and Living with Cancer Study

Conference Cancer Epidemiology, Biomarkers & Prevention · January 1, 2023 AbstractIntroduction: While some cancer survivors experience minimal lasting effects of diagnosis and treatment, others report persistent decrements in physical and cognitive function. These changes may repr ... Full text Cite

Falls and hospitalization during chemotherapy in older women with early breast cancer

Conference JOURNAL OF CLINICAL ONCOLOGY · 2023 Cite

Associations of frailty with overall survival (OS) and functional decline among older adults with non-small-cell lung cancer (NSCLC) receiving chemotherapy, immunotherapy, and/ or targeted therapy

Conference JOURNAL OF CLINICAL ONCOLOGY · 2023 Cite

A pilot study to assess the feasibility of a remotely monitored high-intensity interval training program prior to allogeneic hematopoietic stem cell transplantation.

Journal Article PLoS One · 2023 INTRODUCTION: Although allogeneic hematopoietic stem cell transplantation (HCT) can be a curative therapy for hematologic disorders, it is associated with treatment-related complications and losses in cardiorespiratory fitness and physical function. High-i ... Full text Link to item Cite

Associating persistent self-reported cognitive decline with neurocognitive decline in older breast cancer survivors using machine learning: The Thinking and Living with Cancer study.

Journal Article Journal of geriatric oncology · November 2022 IntroductionMany cancer survivors report cognitive problems following diagnosis and treatment. However, the clinical significance of patient-reported cognitive symptoms early in survivorship can be unclear. We used a machine learning approach to d ... Full text Cite

Causal analysis identifies small HDL particles and physical activity as key determinants of longevity of older adults.

Journal Article EBioMedicine · November 2022 BACKGROUND: The hard endpoint of death is one of the most significant outcomes in both clinical practice and research settings. Our goal was to discover direct causes of longevity from medically accessible data. METHODS: Using a framework that combines loc ... Full text Link to item Cite

Associations between longitudinal changes in sleep disturbance and depressive and anxiety symptoms during the COVID-19 virus pandemic among older women with and without breast cancer in the thinking and living with breast cancer study.

Journal Article Cancer Med · September 2022 PURPOSE: Several studies have reported sleep disturbances during the COVID-19 virus pandemic. Little data exist about the impact of the pandemic on sleep and mental health among older women with breast cancer. We sought to examine whether women with and wi ... Full text Link to item Cite

Harvest for Health, a Randomized Controlled Trial Testing a Home-Based, Vegetable Gardening Intervention Among Older Cancer Survivors Across Alabama: An Analysis of Accrual and Modifications Made in Intervention Delivery and Assessment During COVID-19.

Journal Article J Acad Nutr Diet · September 2022 BACKGROUND: Accelerated functional decline is a concern among older cancer survivors that threatens independence and quality of life. Pilot studies suggest that vegetable gardening interventions ameliorate functional decline through improved diet and physi ... Full text Link to item Cite

Association between cognitive impairment and oral anticancer agent use in older patients with metastatic renal cell carcinoma.

Journal Article J Am Geriatr Soc · August 2022 BACKGROUND: Kidney cancer is the fastest-growing cancer diagnosis in the developed world. About 16% of new cases are stage IV, which has a low five-year survival rate. Many patients with metastatic renal cell carcinoma (mRCC) are older and may have mild co ... Full text Link to item Cite

Geriatric Assessment Reveals Actionable Impairments in Hematopoietic Stem Cell Transplantation Candidates Age 18 to 80 Years.

Journal Article Transplant Cell Ther · August 2022 Allogeneic hematopoietic stem cell transplantation (HCT) is a potentially curative treatment for both malignant and nonmalignant hematologic diseases; however, reported rates of treatment-related mortality approach 30%. Outcomes are worse in patients who b ... Full text Link to item Cite

Association of markers of tumor aggressivity and cognition in women with breast cancer before adjuvant treatment: The Thinking and Living with Cancer Study.

Journal Article Breast Cancer Res Treat · July 2022 PURPOSE: Tumor features associated with aggressive cancers may affect cognition prior to systemic therapy. We evaluated associations of cognition prior to adjuvant therapy and tumor aggressivity in older breast cancer patients. METHODS: Women diagnosed wit ... Full text Link to item Cite

Evaluation of mild cognitive impairment and dementia in patients with metastatic renal cell carcinoma.

Journal Article J Geriatr Oncol · June 2022 BACKGROUND: Dementia and cancer are both more common in adults as they age. As new cancer treatments become more popular, it is important to consider how these treatments might affect older patients. This study evaluates metastatic renal cell carcinoma (mR ... Full text Link to item Cite

"You have to be sure that the patient has the full picture": Adaptation of the Best Case/Worst Case communication tool for geriatric oncology.

Journal Article J Geriatr Oncol · June 2022 BACKGROUND: Shared decision making (SDM) is especially important for older adults with cancer given the risks of over- and undertreatment, uncertainty regarding benefits/harms worsened by research underrepresentation, and individual preferences. We aimed t ... Full text Link to item Cite

Risk Factors for Hospitalizations Among Older Adults with Gastrointestinal Cancers.

Journal Article Oncologist · February 3, 2022 BACKGROUND: Older adults (≥65 years) with gastrointestinal (GI) cancers who receive chemotherapy are at increased risk of hospitalization caused by treatment-related toxicity. Geriatric assessment (GA) has been previously shown to predict risk of toxicity ... Full text Link to item Cite

Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.

Journal Article Ann Clin Transl Neurol · February 2022 OBJECTIVE: Numerous investigators have theorized that postoperative changes in Alzheimer's disease neuropathology may underlie postoperative neurocognitive disorders. Thus, we determined the relationship between postoperative changes in cognition and cereb ... Full text Open Access Link to item Cite

Relationship Between Depression/Anxiety and Cognitive Function Before and 6 Weeks After Major Non-Cardiac Surgery in Older Adults.

Journal Article J Geriatr Psychiatry Neurol · January 2022 OBJECTIVE: To determine the relationship between affective measures and cognition before and after non-cardiac surgery in older adults. METHODS: Observational prospective cohort study in 103 surgical patients age ≥ 60 years old. All participants underwent ... Full text Link to item Cite

Disparities in older adult accrual to cancer trials: Analysis from the alliance for clinical trials in oncology (A151736).

Journal Article J Geriatr Oncol · January 2022 BACKGROUND: Older adults are under-represented in cancer clinical trials. However, it remains unclear which types of trials under-enroll aging patients. We aimed to identify associations between trial characteristics and disparate enrollment of older adult ... Full text Link to item Cite

Changes in older adults' life space during lung cancer treatment: A mixed methods cohort study.

Journal Article J Am Geriatr Soc · January 2022 BACKGROUND: Maintenance of function during cancer treatment is important to older adults. Characteristics associated with pretreatment life-space mobility and changes during non-small cell lung cancer (NSCLC) treatment remain unknown. METHODS: This mixed m ... Full text Link to item Cite

Perceptions of specialty palliative care and its role in pediatric stem cell transplant: A multidisciplinary qualitative study.

Journal Article Pediatr Blood Cancer · January 2022 BACKGROUND: Consultation of specialty palliative care remains uncommon in pediatric stem cell transplant (SCT) despite growing evidence that early integration of palliative care improves outcomes in patients with advanced cancers or undergoing SCT. Little ... Full text Link to item Cite

Impact of taxane-based chemotherapy among older women with breast cancer on cognition and quality of life: a longitudinal pooled analysis.

Journal Article Breast Cancer Res Treat · January 2022 PURPOSE: Older cancer patients are susceptible to long-term effects of chemotherapy, including cancer-related cognitive decline and impairments to quality of life. Taxane-based chemotherapies are associated with physical declines among older women and may ... Full text Link to item Cite

Cognitive and cerebrospinal fluid Alzheimer's Disease biomarker changes over time in older surgical patients and matched nonsurgical controls

Conference ANESTHESIA AND ANALGESIA · 2022 Cite

Preoperative EEG Inattention Signatures and Postoperative Delirium

Conference ANESTHESIA AND ANALGESIA · 2022 Cite

Functional decline in older breast cancer survivors treated with and without chemotherapy and non-cancer controls.

Conference JOURNAL OF CLINICAL ONCOLOGY · 2022 Cite

Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study.

Journal Article Br J Anaesth · December 2021 BACKGROUND: Cognitive dysfunction after surgery is a major issue in older adults. Here, we determined the effect of APOE4 on perioperative neurocognitive function in older patients. METHODS: We enrolled 140 English-speaking patients ≥60 yr old scheduled fo ... Full text Open Access Link to item Cite

Early-pregnancy prediction of risk for pre-eclampsia using maternal blood leptin/ceramide ratio: discovery and confirmation.

Journal Article BMJ Open · November 25, 2021 OBJECTIVE: This study aimed to develop a blood test for the prediction of pre-eclampsia (PE) early in gestation. We hypothesised that the longitudinal measurements of circulating adipokines and sphingolipids in maternal serum over the course of pregnancy c ... Full text Link to item Cite

A template for physical resilience research in older adults: Methods of the PRIME-KNEE study.

Journal Article J Am Geriatr Soc · November 2021 BACKGROUND: Older adults with similar health conditions often experience widely divergent outcomes following health stressors. Variable recovery after a health stressor may be due in part to differences in biological mechanisms at the molecular, cellular, ... Full text Link to item Cite

Applying a Life Course Biological Age Framework to Improving the Care of Individuals With Adult Cancers: Review and Research Recommendations.

Journal Article JAMA Oncol · November 1, 2021 IMPORTANCE: The practice of oncology will increasingly involve the care of a growing population of individuals with midlife and late-life cancers. Managing cancer in these individuals is complex, based on differences in biological age at diagnosis. Biologi ... Full text Link to item Cite

Medical care disruptions during the first six months of the COVID-19 pandemic: the experience of older breast cancer survivors.

Journal Article Breast Cancer Res Treat · November 2021 PURPOSE: Older cancer survivors required medical care during the COVID-19 pandemic, but there are limited data on medical care in this age group. METHODS: We evaluated care disruptions in a longitudinal cohort of non-metastatic breast cancer survivors aged ... Full text Link to item Cite

Response to Dekker, Stege, and Versteeg.

Journal Article J Natl Cancer Inst · October 1, 2021 Full text Link to item Cite

Loneliness and mental health during the COVID-19 pandemic in older breast cancer survivors and noncancer controls.

Journal Article Cancer · October 1, 2021 BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has had wide-ranging health effects and increased isolation. Older with cancer patients might be especially vulnerable to loneliness and poor mental health during the pandemic. METHODS: The autho ... Full text Link to item Cite

NCCN Guidelines® Insights: Older Adult Oncology, Version 1.2021.

Journal Article J Natl Compr Canc Netw · September 20, 2021 The NCCN Guidelines for Older Adult Oncology address specific issues related to the management of cancer in older adults, including screening and comprehensive geriatric assessment (CGA), assessing the risks and benefits of treatment, preventing or decreas ... Full text Link to item Cite

Geriatric conditions and treatment burden following diagnosis of non-muscle- invasive bladder cancer in older adults: A population-based analysis.

Journal Article J Geriatr Oncol · September 2021 INTRODUCTION: Treatment burden is emerging as an important patient-centered outcome for older adults with cancer who concurrently manage geriatric conditions. Our objective was to evaluate the contribution of geriatric conditions to treatment burden in old ... Full text Link to item Cite

Deficit Accumulation Frailty Trajectories of Older Breast Cancer Survivors and Non-Cancer Controls: The Thinking and Living With Cancer Study.

Journal Article J Natl Cancer Inst · August 2, 2021 BACKGROUND: We evaluated deficit accumulation and how deficits affected cognition and physical activity among breast cancer survivors and non-cancer controls. METHODS: Newly diagnosed nonmetastatic survivors (n = 353) and matched non-cancer controls (n = 3 ... Full text Link to item Cite

Measuring Biologic Resilience in Older Cancer Survivors.

Journal Article J Clin Oncol · July 1, 2021 Full text Link to item Cite

From Assessment to Implementation and Beyond in Cancer and Aging Research.

Journal Article J Clin Oncol · July 1, 2021 Full text Link to item Cite

Predictors of Unplanned Hospitalizations Among Older Adults Receiving Cancer Chemotherapy.

Journal Article JCO Oncol Pract · June 2021 PURPOSE: Hospitalizations during cancer treatment are costly, can impair quality of life, and negatively affect therapy completion. Our objective was to identify risk factors for unplanned hospitalization among older adults receiving chemotherapy. METHODS: ... Full text Link to item Cite

Medical Care Disruptions During the First Six-Months of the COVID19 Pandemic: The Experience of Older Breast Cancer Survivors.

Journal Article Res Sq · April 14, 2021 UNLABELLED: PurposeOlder cancer survivors required medical care during the COVID-19 pandemic despite infection risks, but there are limited data on medical care in this age group. METHODS: We evaluated care disruptions in a longitudinal cohort of non-metas ... Full text Link to item Cite

Protective Effects of APOE ε2 Genotype on Cognition in Older Breast Cancer Survivors: The Thinking and Living With Cancer Study.

Journal Article JNCI Cancer Spectr · April 2021 BACKGROUND: Cancer-related cognitive decline (CRCD) has been linked to apolipoprotein E (APOE) gene ε4 polymorphisms. APOE ε4 polymorphisms are also the strongest genetic risk for late-onset Alzheimer disease (AD), whereas ε2 polymorphisms protect against ... Full text Link to item Cite

Electronic Geriatric Assessment: Is It Feasible in a Multi-Institutional Study That Included a Notable Proportion of Older African American Patients? (Alliance A171603).

Journal Article JCO Clin Cancer Inform · April 2021 PURPOSE: This study determined whether an electronic version of the geriatric assessment is feasible in a multi-institutional, diverse setting. METHODS: Ten sites within the Alliance for Clinical Trials in Oncology participated. Patients who had active can ... Full text Link to item Cite

Expanding Beyond Maximum Grade: Chemotherapy Toxicity over Time by Age and Performance Status in Advanced Non-Small Cell Lung Cancer in CALGB 9730 (Alliance A151729).

Journal Article Oncologist · March 2021 BACKGROUND: Prior comparisons of chemotherapy adverse events (AEs) by age and performance status (PS) are limited by the traditional maximum grade approach, which ignores low-grade AEs and longitudinal changes. MATERIALS AND METHODS: To compare fatigue and ... Full text Link to item Cite

Development and Validation of a Risk Tool for Predicting Severe Toxicity in Older Adults Receiving Chemotherapy for Early-Stage Breast Cancer.

Journal Article J Clin Oncol · February 20, 2021 PURPOSE: Limited tools exist to predict the risk of chemotherapy toxicity in older adults with early-stage breast cancer. METHODS: Patients of age ≥ 65 years with stage I-III breast cancer from 16 institutions treated with neoadjuvant or adjuvant chemother ... Full text Link to item Cite

High-throughput quantitation of serological ceramides/dihydroceramides by LC/MS/MS: Pregnancy baseline biomarkers and potential metabolic messengers.

Journal Article J Pharm Biomed Anal · January 5, 2021 Ceramides and dihydroceramides are sphingolipids that present in abundance at the cellular membrane of eukaryotes. Although their metabolic dysregulation has been implicated in many diseases, our knowledge about circulating ceramide changes during the preg ... Full text Link to item Cite

Older adult participation in cancer clinical trials: A systematic review of barriers and interventions.

Journal Article CA Cancer J Clin · January 2021 Cancer is a disease of aging and, as the world's population ages, the number of older persons with cancer is increasing and will make up a growing share of the oncology population in virtually every country. Despite this, older patients remain vastly under ... Full text Link to item Cite

Inflammation and coagulation biomarkers associated with physical resilience in older women receiving chemotherapy for early breast cancer

Conference CANCER RESEARCH · 2021 Cite

Maternal metabolic profiling to assess fetal gestational age and predict preterm delivery: a two-centre retrospective cohort study in the US.

Journal Article BMJ open · December 2020 ObjectivesThe aim of this study was to develop a single blood test that could determine gestational age and estimate the risk of preterm birth by measuring serum metabolites. We hypothesised that serial metabolic modelling of serum analytes throug ... Full text Cite

Factors associated with falls in older women with breast cancer: the use of a brief geriatric screening tool in clinic.

Journal Article Breast Cancer Res Treat · November 2020 PURPOSE: Unintentional falls and breast cancer are common among older women, but the associations between them are understudied. We aimed to identify factors associated with falls in older women with breast cancer. METHODS: We retrospectively reviewed clin ... Full text Link to item Cite

Markers of Iron Flux during Testosterone-Mediated Erythropoiesis in Older Men with Unexplained or Iron-Deficiency Anemia.

Journal Article J Clin Endocrinol Metab · November 1, 2020 CONTEXT: Testosterone treatment of hypogonadal men improves their hemoglobin, but the mechanism is not understood. OBJECTIVE: To investigate possible mechanisms by which testosterone stimulates erythropoiesis in hypogonadal older men with unexplained or ir ... Full text Link to item Cite

Association of Blood Chemistry Quantifications of Biological Aging With Disability and Mortality in Older Adults.

Journal Article J Gerontol A Biol Sci Med Sci · September 16, 2020 Quantification of biological aging has been proposed for population surveillance of age-related decline in system integrity and evaluation of geroprotective therapies. However, methods of quantifying biological aging have been little studied in geriatric p ... Full text Link to item Cite

A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.

Journal Article J Neurol · July 2020 OBJECTIVE: Lumbar punctures (LPs) are important for obtaining CSF in neurology studies but are associated with adverse events and feared by many patients. We determined adverse event rates and pain scores in patients prospectively enrolled in two cohort st ... Full text Link to item Cite

A reduced transferrin saturation is independently associated with excess morbidity and mortality in older adults with heart failure and incident anemia.

Journal Article Int J Cardiol · June 15, 2020 BACKGROUND: Low transferrin saturation (TSAT) or reduced serum ferritin level are suggestive of iron deficiency but the relationship between iron parameters and outcomes has not been systematically evaluated in older adults with heart failure (HF) and anem ... Full text Link to item Cite

Cognitive function prior to systemic therapy and subsequent well-being in older breast cancer survivors: Longitudinal findings from the Thinking and Living with Cancer Study.

Journal Article Psychooncology · June 2020 OBJECTIVE: To investigate the relationships between self-reported and objectively measured cognitive function prior to systemic therapy and subsequent well-being outcomes over 24 months in older breast cancer survivors. METHODS: Data were from 397 women ag ... Full text Link to item Cite

Physical Activity in the Hospital: Documentation and Influence on Venous Thromboembolism Prophylaxis.

Journal Article J Aging Phys Act · April 24, 2020 This study describes the availability of physical activity information in the electronic health record, explores how electronic health record documentation correlates with accelerometer-derived physical activity data, and examines whether measured physical ... Full text Link to item Cite

Symptom burden among older breast cancer survivors: The Thinking and Living With Cancer (TLC) study.

Journal Article Cancer · March 15, 2020 BACKGROUND: Little is known about longitudinal symptom burden, its consequences for well-being, and whether lifestyle moderates the burden in older survivors. METHODS: The authors report on 36-month data from survivors aged ≥60 years with newly diagnosed, ... Full text Link to item Cite

Arti Hurria, M.D.: A tribute to her shining legacy in the Alliance for Clinical Trials in Oncology.

Journal Article J Geriatr Oncol · March 2020 Full text Link to item Cite

Geriatric oncology health services research: Cancer and Aging Research Group infrastructure core.

Journal Article J Geriatr Oncol · March 2020 Full text Link to item Cite

Arti Hurria and the progress in integrating the geriatric assessment into oncology: Young International Society of Geriatric Oncology review paper.

Journal Article J Geriatr Oncol · March 2020 Until recently, the progress in the diagnosis and management of cancer has not been matched by similar progress in the assessment of the increasing numbers of older and more complex patients with cancer. Dr. Arti Hurria identified this gap at the outset of ... Full text Link to item Cite

The association between social support and chemotherapy-related toxicity in older patients with cancer.

Journal Article J Geriatr Oncol · March 2020 OBJECTIVES: The goal of this study was to evaluate the relationship between social support (SS) and grade 3-5 chemotherapy-related toxicities among older adults with cancer. METHODS: This is a secondary analysis of a prospective longitudinal study of patie ... Full text Link to item Cite

Abstract PD10-10: Factors associated with decreased relative dose intensity in older adults with early-stage breast cancer receiving chemotherapy

Conference Cancer Research · February 15, 2020 AbstractBackground: Older adults with breast cancer receiving neo/adjuvant chemotherapy are at increased risk for toxicity and dose reductions, often leading to decreased relative dose intensity (dRDI &l ... Full text Cite

Race/Ethnic and Educational Disparities in the Association Between Pathogen Burden and a Laboratory-Based Cumulative Deficits Index.

Journal Article J Racial Ethn Health Disparities · February 2020 BACKGROUND: Disparities in adult morbidity and mortality may be rooted in patterns of biological dysfunction in early life. We sought to examine the association between pathogen burden and a cumulative deficits index (CDI), conceptualized as a pre-clinical ... Full text Link to item Cite

Accelerometer-Measured Hospital Physical Activity and Hospital-Acquired Disability in Older Adults.

Journal Article J Am Geriatr Soc · February 2020 BACKGROUND: Hospital-acquired disability (HAD) is common and often related to low physical activity while in the hospital. OBJECTIVE: To examine whether wearable hospital activity trackers can be used to predict HAD. DESIGN: A prospective observational stu ... Full text Link to item Cite

Geriatric assessment among older adults receiving intensive therapy for acute myeloid leukemia: Report of CALGB 361006 (Alliance).

Journal Article J Geriatr Oncol · January 2020 OBJECTIVE: To demonstrate feasibility of performing geriatric assessment (GA) in the National Clinical Trials Network (NCTN) and to explore the utility of GA to characterize treatment tolerance. MATERIALS AND METHODS: We conducted a multisite companion stu ... Full text Link to item Cite

Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors.

Journal Article J Natl Cancer Inst · December 1, 2019 Observational data have shown that some cancer survivors develop chronic conditions like frailty, sarcopenia, cardiac dysfunction, and mild cognitive impairment earlier and/or at a greater burden than similarly aged individuals never diagnosed with cancer ... Full text Link to item Cite

Effects of cancer history on functional age and mortality.

Journal Article Cancer · December 1, 2019 BACKGROUND: Cancer, its treatment, and associated adverse effects may accelerate the functional aging of cancer survivors. In the current study, the authors used geriatric assessment (GA) to compare the functional age of long-term cancer survivors with tha ... Full text Link to item Cite

Flow Cytometry Characterization of Cerebrospinal Fluid Monocytes in Patients With Postoperative Cognitive Dysfunction: A Pilot Study.

Journal Article Anesth Analg · November 2019 Animal models suggest postoperative cognitive dysfunction may be caused by brain monocyte influx. To study this in humans, we developed a flow cytometry panel to profile cerebrospinal fluid (CSF) samples collected before and after major noncardiac surgery ... Full text Open Access Link to item Cite

Cancer statistics for adults aged 85 years and older, 2019.

Journal Article CA Cancer J Clin · November 2019 Adults aged 85 years and older, the "oldest old," are the fastest-growing age group in the United States, yet relatively little is known about their cancer burden. Combining data from the National Cancer Institute, the North American Association of Central ... Full text Link to item Cite

Association of Neurocognitive and Physical Function With Gait Speed in Midlife.

Journal Article JAMA Netw Open · October 2, 2019 IMPORTANCE: Gait speed is a well-known indicator of risk of functional decline and mortality in older adults, but little is known about the factors associated with gait speed earlier in life. OBJECTIVES: To test the hypothesis that slow gait speed reflects ... Full text Link to item Cite

Incident anaemia in older adults with heart failure: rate, aetiology, and association with outcomes.

Journal Article Eur Heart J Qual Care Clin Outcomes · October 1, 2019 AIMS: Limited data exist on the epidemiology, evaluation, and prognosis of otherwise unexplained anaemia of the elderly in heart failure (HF). Thus, we aimed to determine the incidence of anaemia, to characterize diagnostic testing patterns for potentially ... Full text Link to item Cite

Randomized Trial of Standard Adjuvant Chemotherapy Regimens Versus Capecitabine in Older Women With Early Breast Cancer: 10-Year Update of the CALGB 49907 Trial.

Journal Article J Clin Oncol · September 10, 2019 PURPOSE: Older women with breast cancer remain under-represented in clinical trials. The Cancer and Leukemia Group B 49907 trial focused on women age 65 years and older. We previously reported the primary analysis after a median follow-up of 2.4 years. Sta ... Full text Link to item Cite

Creating the Next Generation of Translational Geroscientists.

Journal Article J Am Geriatr Soc · September 2019 Advances in understanding fundamental processes of aging have led to a variety of investigational therapies to delay or prevent age-related diseases and conditions. These geroscience therapeutics hold the promise of revolutionizing medical care of older ad ... Full text Link to item Cite

Association of Sensory and Cognitive Impairment With Healthcare Utilization and Cost in Older Adults.

Journal Article J Am Geriatr Soc · August 2019 OBJECTIVES: To examine the association between self-reported vision impairment (VI), hearing impairment (HI), and dual-sensory impairment (DSI), stratified by dementia status, on hospital admissions, hospice use, and healthcare costs. DESIGN: Retrospective ... Full text Link to item Cite

Moving Frailty Toward Clinical Practice: NIA Intramural Frailty Science Symposium Summary.

Journal Article J Am Geriatr Soc · August 2019 Frailty has long been an important concept in the practice of geriatric medicine and in gerontological research, but integration and implementation of frailty concepts into clinical practice in the United States has been slow. The National Institute on Agi ... Full text Link to item Cite

Clinical prognostic model for older patients with advanced non-small cell lung cancer.

Journal Article J Geriatr Oncol · July 2019 BACKGROUND: Older patients with non-small cell lung cancer (NSCLC) are often not prescribed standard therapy. It is important to know which older patients would be candidates for aggressive therapy based on their prognosis, and to develop a model that can ... Full text Link to item Cite

Older-Patient-Specific Cancer Trials: A Pooled Analysis of 2,277 Patients (A151715).

Journal Article Oncologist · June 2019 BACKGROUND: Less than 3% of older patients with cancer are enrolled in clinical trials. To reverse this underrepresentation, we compared older patients enrolled with older-patient-specific trials, defined as those designed for older patients with cancer, w ... Full text Link to item Cite

Functional Decline and Resilience in Older Women Receiving Adjuvant Chemotherapy for Breast Cancer.

Journal Article J Am Geriatr Soc · May 2019 OBJECTIVES: To analyze self-reported changes in physical function in older women with breast cancer receiving adjuvant chemotherapy. DESIGN: Secondary analysis of the Cancer and Leukemia Group B (CALGB) 49907 prospective randomized clinical trial. SETTING: ... Full text Link to item Cite

Age and the Risk of Paclitaxel-Induced Neuropathy in Women with Early-Stage Breast Cancer (Alliance A151411): Results from 1,881 Patients from Cancer and Leukemia Group B (CALGB) 40101.

Journal Article Oncologist · May 2019 PURPOSE: A few previous studies report a direct relationship between older age and chemotherapy-induced neuropathy. This study further evaluated this adverse event's age-based risk. METHODS: CALGB 40101 investigated adjuvant paclitaxel (80 mg/m2 once per w ... Full text Link to item Cite

The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.

Journal Article J Am Geriatr Soc · April 2019 BACKGROUND/OBJECTIVES: Every year, up to 40% of the more than 16 million older Americans who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD) or delirium. Each of these distinct syndromes is associated with decreased quality of ... Full text Open Access Link to item Cite

Going Far Together: A Tribute to Arti Hurria, MD.

Journal Article J Am Geriatr Soc · March 2019 Full text Link to item Cite

Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood.

Journal Article J Gerontol A Biol Sci Med Sci · February 15, 2019 Aging is characterized by deleterious immune and metabolic changes, but the onset of these changes is unknown. We measured immune and metabolic biomarkers in adults beginning at age 30. To our knowledge, this is the first study to evaluate these biomarkers ... Full text Open Access Link to item Cite

A pooled analysis of individual patient data from National Clinical Trials Network clinical trials of concurrent chemoradiotherapy for limited-stage small cell lung cancer in elderly patients versus younger patients.

Journal Article Cancer · February 1, 2019 BACKGROUND: Platinum and etoposide with thoracic radiation followed by prophylactic cranial irradiation constitute the standard treatment for limited-stage small cell lung cancer (LS-SCLC). Many patients with LS-SCLC are elderly with comorbidities. METHODS ... Full text Link to item Cite

THE INTUIT STUDY: INVESTIGATING NEUROINFLAMMATION UNDERLYING POSTOPERATIVE NEUROCOGNITIVE DYSFUNCTION AND DELIRIUM IN OLDER ADULTS

Conference ANESTHESIA AND ANALGESIA · 2019 Cite

Investigating pathogen burden in relation to a cumulative deficits index in a representative sample of US adults.

Journal Article Epidemiol Infect · November 2018 Pathogen burden is a construct developed to assess the cumulative effects of multiple, persistent pathogens on morbidity and mortality. Despite the likely biological wear and tear on multiple body systems caused by persistent infections, few studies have e ... Full text Open Access Link to item Cite

Multidisciplinary development of the Geriatric Core Dataset for clinical research in older patients with cancer: A French initiative with international survey.

Journal Article Eur J Cancer · November 2018 BACKGROUND: To define a core set of geriatric data to be methodically collected in clinical cancer trials of older adults, enabling comparison across trials. PATIENTS AND METHODS: Following a consensus approach, a panel of 14 geriatricians from oncology cl ... Full text Link to item Cite

Aging

Chapter · October 31, 2018 Full text Cite

Factors associated with falls in older adults with cancer: a validated model from the Cancer and Aging Research Group.

Journal Article Support Care Cancer · October 2018 BACKGROUND: Falls in older adults with cancer are common, yet factors associated with fall-risk are not well-defined and may differ from the general geriatric population. This study aims to develop and validate a model of factors associated with prior fall ... Full text Link to item Cite

A pooled analysis of individual patient data (IPD) of concurrent chemoradiotherapy for limited-stage small cell lung cancer (LS-SCLC) in elderly compared to younger patients (pts) who participated in US National Cancer Institute cooperative group studies.

Conference Ann Oncol · October 2018 Full text Link to item Cite

Promoting Accrual of Older Patients with Cancer to Clinical Trials: An Alliance for Clinical Trials in Oncology Member Survey (A171602).

Journal Article Oncologist · September 2018 BACKGROUND: There are multiple known individual- and practice-level barriers to enrollment of older patients with cancer to clinical trials, but little is known about how the clinical research workforce feels about potential higher-level strategy changes a ... Full text Link to item Cite

Identification of risk factors for toxicity in patients with hormone receptor-positive advanced breast cancer treated with bevacizumab plus letrozole: a CALGB 40503 (alliance) correlative study.

Journal Article Breast Cancer Res Treat · September 2018 BACKGROUND: In hormone receptor-positive advanced breast cancer, a progression-free survival benefit was reported with addition of bevacizumab to first-line letrozole. However, increased toxicity was observed. We hypothesized that functional age measures c ... Full text Link to item Cite

Do older patients with non-small cell lung cancer also benefit from first-line platinum-based doublet chemotherapy? Observations from a pooled analysis of 730 prospectively-treated patients (Alliance Study A151622).

Journal Article J Geriatr Oncol · September 2018 OBJECTIVE: This study sought to define the role of first-line platinum-based doublet chemotherapy in older patients with non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: We analyzed three first-line NSCLC trials: CALGB 9730, CALGB 30203, and CALG ... Full text Link to item Cite

Physical Resilience: Not Simply the Opposite of Frailty.

Journal Article J Am Geriatr Soc · August 2018 Full text Link to item Cite

Association between patient-reported hearing and visual impairments and functional, psychological, and cognitive status among older adults with cancer.

Journal Article Cancer · August 1, 2018 BACKGROUND: Hearing and visual impairments are common among community-dwelling older adults, and are associated with psychological, functional, and cognitive deficits. However, to the authors' knowledge, little is known regarding their prevalence among old ... Full text Link to item Cite

Practical Assessment and Management of Vulnerabilities in Older Patients Receiving Chemotherapy: ASCO Guideline for Geriatric Oncology.

Journal Article J Clin Oncol · August 1, 2018 Purpose To provide guidance regarding the practical assessment and management of vulnerabilities in older patients undergoing chemotherapy. Methods An Expert Panel was convened to develop clinical practice guideline recommendations based on a systematic re ... Full text Link to item Cite

A home-based mentored vegetable gardening intervention demonstrates feasibility and improvements in physical activity and performance among breast cancer survivors.

Journal Article Cancer · August 2018 BACKGROUND: The current study assessed the feasibility of a mentored home-based vegetable gardening intervention and examined changes in health-related outcomes among breast cancer survivors (BCS). METHODS: BCS were randomized to either a year-long vegetab ... Full text Link to item Cite

Time-to-Treatment-Failure and Related Outcomes Among 1000+ Advanced Non-Small Cell Lung Cancer Patients: Comparisons Between Older Versus Younger Patients (Alliance A151711).

Journal Article J Thorac Oncol · July 2018 INTRODUCTION: Time-to-treatment-failure (TTF) is the interval from chemotherapy initiation to premature discontinuation. We evaluated TTF based on age. METHODS: Pooled analyses were conducted with first-line chemotherapy trials for advanced NSCLC (CALGB 97 ... Full text Link to item Cite

Frequency and impact of grade three or four toxicities of novel agents on outcomes of older patients with chronic lymphocytic leukemia and non-Hodgkin lymphoma (alliance A151611).

Journal Article J Geriatr Oncol · July 2018 OBJECTIVE: Older patients with cancer suffer from chemotherapy-related toxicities more frequently than younger patients. As novel agents are being used more commonly in chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL), toxicities of these ... Full text Link to item Cite

Combined Inflammation and Metabolism Biomarker Indices of Robust and Impaired Physical Function in Older Adults.

Journal Article J Am Geriatr Soc · July 2018 OBJECTIVES: To determine whether combinations of inflammatory markers are related to physical function. DESIGN AND SUBJECTS: secondary analysis of baseline of three observational studies of community-dwelling older adults MEASUREMENTS: The baseline data fr ... Full text Open Access Link to item Cite

Automated versus Manual Data Extraction of the Padua Prediction Score for Venous Thromboembolism Risk in Hospitalized Older Adults.

Journal Article Appl Clin Inform · July 2018 OBJECTIVE: Venous thromboembolism (VTE) prophylaxis is an important consideration for hospitalized older adults, and the Padua Prediction Score (PPS) is a risk prediction tool used to prioritize patient selection. We developed an automated PPS (APPS) algor ... Full text Link to item Cite

Poor Adherence to Risk Stratification Guidelines Results in Overuse of Venous Thromboembolism Prophylaxis in Hospitalized Older Adults.

Journal Article J Hosp Med · June 1, 2018 Full text Open Access Link to item Cite

Lessons From the Testosterone Trials.

Journal Article Endocr Rev · June 1, 2018 The Testosterone Trials (TTrials) were a coordinated set of seven placebo-controlled, double-blind trials in 788 men with a mean age of 72 years to determine the efficacy of increasing the testosterone levels of older men with low testosterone. Testosteron ... Full text Link to item Cite

The impact of actual body weight-based chemotherapy dosing and body size on adverse events and outcome in older patients with breast cancer: Results from Cancer and Leukemia Group B (CALGB) trial 49907 (Alliance A151436).

Journal Article J Geriatr Oncol · May 2018 OBJECTIVE: Actual weight-based (AWB) chemotherapy dosing is recommended for obese patients in the 2012 ASCO Clinical Practice Guideline. CALGB 49907, which utilized ABW-based adjuvant chemotherapy dosing, was a phase 3 trial in women age≥65years with early ... Full text Link to item Cite

The preference to receive chemotherapy and cancer-related outcomes in older adults with breast cancer CALGB 49907 (Alliance).

Journal Article J Geriatr Oncol · May 2018 OBJECTIVE: Chemotherapy preference refers to a patient's interest in receiving chemotherapy. This study examined whether chemotherapy preference was associated with toxicity, efficacy, quality of life (QoL), and functional outcomes during and after complet ... Full text Link to item Cite

Is objective mobility data associated with pharmacologic venous thromboembolism (VTE) prophylaxis use among hospitalized older adults?

Conference Journal of Hospital Medicine · April 10, 2018 Background: Clinical practice guidelines state that mobility is supposed to play an important role in determining use and duration of pharmacologic VTE prophylaxis. This study examines whether measured mobility levels relate to pharmacologic VTE prophylaxi ... Open Access Link to item Cite

Pilot Randomized Controlled Trial of a Home Vegetable Gardening Intervention among Older Cancer Survivors Shows Feasibility, Satisfaction, and Promise in Improving Vegetable and Fruit Consumption, Reassurance of Worth, and the Trajectory of Central Adiposity.

Journal Article J Acad Nutr Diet · April 2018 BACKGROUND: Holistic approaches are sought to improve lifestyle behaviors and health of cancer survivors long term. OBJECTIVE: Our aim was to explore whether a home-based vegetable gardening intervention is feasible and whether it improves diet and other h ... Full text Link to item Cite

PERIOPERATIVE TRAJECTORY OF ALZHEIMER'S DISEASE BIOMARKERS IN SURGICAL PATIENTS AND MATCHED NON-SURGICAL CONTROLS

Conference ANESTHESIA AND ANALGESIA · April 1, 2018 Link to item Cite

Evolution of Geriatric Assessment in Oncology.

Journal Article J Oncol Pract · February 2018 Full text Link to item Cite

The Impact of Multiple Dimensions of Socioeconomic Status on Physical Functioning Across the Life Course.

Journal Article Gerontol Geriatr Med · 2018 Objective: We used the Physical Performance Across the LifeSpan Study to investigate the relationships of multiple indicators of socioeconomic status (SES), both in early life and late life, with physical function. Method: We examined associations between ... Full text Open Access Link to item Cite

Perspectives on aging: Progress and priorities for age-related cancers

Chapter · January 1, 2018 This chapter shows that the research priorities in the biologic, psychosocial, and clinical aspects of the age-related cancers. It addresses aging and the clinical course of cancer. One example is breast cancer. The chapter discusses management issues and ... Full text Cite

Lymphedema, musculoskeletal events and arm function in older patients receiving adjuvant chemotherapy for breast cancer (Alliance A171302).

Journal Article Breast Cancer Res Treat · December 2017 PURPOSE: Musculoskeletal events (MEs) resulting from breast cancer treatment can significantly interfere with the quality of life (QOL) of older adults. We evaluated the incidence of MEs in women 65 years and older who had surgery and adjuvant chemotherapy ... Full text Link to item Cite

Personality, coping, and social support as predictors of long-term quality-of-life trajectories in older breast cancer survivors: CALGB protocol 369901 (Alliance).

Journal Article Psychooncology · November 2017 BACKGROUND: To determine long-term quality-of-life (QOL) trajectories among breast cancer survivors aged 65+ (older) evaluating the effects of personality and social support. METHODS: Older women (N = 1280) newly examined with invasive, nonmetastatic breas ... Full text Link to item Cite

Comparative "nocebo effects" in older patients enrolled in cancer therapeutic trials: Observations from a 446-patient cohort.

Journal Article Cancer · November 1, 2017 BACKGROUND: A nocebo is an inert substance associated with adverse events. Although previous studies have examined the positive (placebo) effects of such inert substances, few have examined negative (nocebo) adverse event profiles, particularly in older pa ... Full text Link to item Cite

Cognitive function and discontinuation of adjuvant hormonal therapy in older breast cancer survivors: CALGB 369901 (Alliance).

Journal Article Breast Cancer Res Treat · October 2017 PURPOSE: To investigate the effects of cognitive function on discontinuation of hormonal therapy in breast cancer survivors ages 65+ ("older"). METHODS: Older breast cancer survivors with invasive, non-metastatic disease, and no reported cognitive difficul ... Full text Link to item Cite

Pooled Analysis of Individual Patient Data on Concurrent Chemoradiotherapy for Stage III Non-Small-Cell Lung Cancer in Elderly Patients Compared With Younger Patients Who Participated in US National Cancer Institute Cooperative Group Studies.

Journal Article J Clin Oncol · September 1, 2017 Purpose Concurrent chemoradiotherapy is standard treatment for patients with stage III non-small-cell lung cancer. Elderly patients may experience increased rates of adverse events (AEs) or less benefit from concurrent chemoradiotherapy. Patients and Metho ... Full text Link to item Cite

A Cumulative Deficit Laboratory Test-based Frailty Index: Personal and Neighborhood Associations.

Journal Article J Am Geriatr Soc · September 2017 OBJECTIVES: To explore the association between a newly developed cumulative laboratory-based frailty index (FI) and intrinsic (personal) and extrinsic (social, environmental) characteristics. DESIGN: Cross-sectional longitudinal study. SETTING: The third a ... Full text Link to item Cite

Redefining Unexplained Anemia in Elderly-Reply.

Journal Article JAMA Intern Med · September 1, 2017 Full text Link to item Cite

Impact of early personal-history characteristics on the Pace of Aging: implications for clinical trials of therapies to slow aging and extend healthspan.

Journal Article Aging Cell · August 2017 Therapies to extend healthspan are poised to move from laboratory animal models to human clinical trials. Translation from mouse to human will entail challenges, among them the multifactorial heterogeneity of human aging. To inform clinical trials about th ... Full text Link to item Cite

Frailty and long-term mortality of older breast cancer patients: CALGB 369901 (Alliance).

Journal Article Breast Cancer Res Treat · July 2017 PURPOSE: Breast cancer patients aged 65+ ("older") vary in frailty status. We tested whether a deficits accumulation frailty index predicted long-term mortality. METHODS: Older patients (n = 1280) with non-metastatic, invasive breast cancer were recruited ... Full text Link to item Cite

Using ePrognosis to estimate 2-year all-cause mortality in older women with breast cancer: Cancer and Leukemia Group B (CALGB) 49907 and 369901 (Alliance A151503).

Journal Article Breast Cancer Res Treat · June 2017 PURPOSE: Tools to estimate survival, such as ePrognosis ( http://eprognosis.ucsf.edu/carey2.php ), were developed for general, not cancer, populations. In older patients with breast cancer, accurate overall survival estimates would facilitate discussions a ... Full text Link to item Cite

Impact of hearing and visual impairment in older adults with cancer.

Conference Journal of Clinical Oncology · May 20, 2017 10036 Background: Hearing and visual impairment increase the risk of psychological, functional, and cognitive deficits in older adults. However, little is known about their impact in older patients (pts) with cancer. Methods: Thi ... Full text Cite

Physical Performance Across the Adult Life Span: Correlates With Age and Physical Activity.

Journal Article J Gerontol A Biol Sci Med Sci · April 1, 2017 BACKGROUND: A number of large-scale population studies have provided valuable information about physical performance in aged individuals; however, there is little information about trajectories of function and associations with age across the adult life sp ... Full text Link to item Cite

Association of Testosterone Levels With Anemia in Older Men: A Controlled Clinical Trial.

Journal Article JAMA Intern Med · April 1, 2017 IMPORTANCE: In one-third of older men with anemia, no recognized cause can be found. OBJECTIVE: To determine if testosterone treatment of men 65 years or older with unequivocally low testosterone levels and unexplained anemia would increase their hemoglobi ... Full text Link to item Cite

Accrual of Older Patients With Breast Cancer to Alliance Systemic Therapy Trials Over Time: Protocol A151527.

Journal Article J Clin Oncol · February 2017 Purpose Despite increasing awareness of accrual challenges, it is unknown if accrual of older patients to breast cancer treatment trials is improving. Methods We examined accrual of older patients to Alliance for Clinical Trials in Oncology systemic therap ... Full text Link to item Cite

Response to Letter From De Alfieri et al.: Biological Resilience of Elderly Hospitalized Patients.

Journal Article J Gerontol A Biol Sci Med Sci · January 2017 Full text Link to item Cite

Risk of acute myeloid leukemia and myelodysplastic syndrome among older women receiving anthracycline-based adjuvant chemotherapy for breast cancer on Modern Cooperative Group Trials (Alliance A151511).

Journal Article Breast Cancer Res Treat · January 2017 PURPOSE: We examined acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) events among 9679 women treated for breast cancer on four adjuvant Alliance for Clinical Trials in Oncology trials with >90 months of follow-up in order to better characte ... Full text Link to item Cite

Frailty as determined by a comprehensive geriatric assessment-derived deficit-accumulation index in older patients with cancer who receive chemotherapy.

Journal Article Cancer · December 15, 2016 BACKGROUND: Frailty has been suggested as a construct for oncologists to consider in treating older cancer patients. Therefore, the authors assessed the potential of creating a deficit-accumulation frailty index (DAFI) from a largely self-administered comp ... Full text Link to item Cite

Toxicities and Related Outcomes of Elderly Patients (pts) (≥65 Years) with Hematologic Malignancies in the Contemporary Era (Alliance A151611)

Conference Blood · December 2, 2016 AbstractBackground: Contemporary approaches to non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL) incorporate chemo-immunotherapy, biologic combinations, and immune modulating agents; toxiciti ... Full text Cite

Disease drivers of aging.

Journal Article Ann N Y Acad Sci · December 2016 It has long been known that aging, at both the cellular and organismal levels, contributes to the development and progression of the pathology of many chronic diseases. However, much less research has examined the inverse relationship-the contribution of c ... Full text Link to item Cite

Reliability, Validity, and Feasibility of a Computer-Based Geriatric Assessment for Older Adults With Cancer.

Journal Article J Oncol Pract · December 2016 PURPOSE: The goal of this study was to evaluate the feasibility, reliability, and validity of a computer-based geriatric assessment via two methods of electronic data capture ( SupportScreen and REDCap) compared with paper-and-pencil data capture among old ... Full text Link to item Cite

Enrollment Trends and Disparity Among Patients With Lung Cancer in National Clinical Trials, 1990 to 2012.

Journal Article J Clin Oncol · November 20, 2016 Purpose Under-representation of elderly, women, and racial/ethnic minority patients with cancer in clinical trials is of national concern. The goal of this study was to characterize enrollment trends and disparities by age, sex, and race/ethnicity in lung ... Full text Link to item Cite

Long-term trajectories of self-reported cognitive function in a cohort of older survivors of breast cancer: CALGB 369901 (Alliance).

Journal Article Cancer · November 15, 2016 BACKGROUND: The number of survivors of breast cancer aged ≥65 years ("older") is growing, but to the authors' knowledge, little is known regarding the cognitive outcomes of these individuals. METHODS: A cohort of cognitively intact older survivors with non ... Full text Link to item Cite

Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations.

Journal Article J Gerontol A Biol Sci Med Sci · November 2016 BACKGROUND: Older age and obesity are associated with metabolic dysregulation; the mechanism by which these factors impact metabolism across the lifespan is important, but relatively unknown. We evaluated a panel of amino acids (AAs) and acylcarnitines (AC ... Full text Link to item Cite

Response to Ukraintseva et al. Letter: Resilience Versus Robustness in Aging.

Journal Article J Gerontol A Biol Sci Med Sci · November 2016 Full text Link to item Cite

Physical resilience of older cancer survivors: An emerging concept.

Journal Article J Geriatr Oncol · November 2016 OBJECTIVES: To characterize factors contributing to physical resilience in older cancer survivors, as demonstrated by resistance to decline or recovery (resilience). MATERIALS AND METHODS: We conducted a secondary analysis of data from a randomized control ... Full text Link to item Cite

NCCN Guidelines Insights: Older Adult Oncology, Version 2.2016.

Journal Article J Natl Compr Canc Netw · November 2016 Cancer is the leading cause of death in older adults aged 60 to 79 years. Older patients with good performance status are able to tolerate commonly used treatment modalities as well as younger patients, particularly when adequate supportive care is provide ... Full text Link to item Cite

Detailed methods of two home-based vegetable gardening intervention trials to improve diet, physical activity, and quality of life in two different populations of cancer survivors.

Journal Article Contemp Clin Trials · September 2016 BACKGROUND: Cancer survivors suffer from long-term adverse effects that reduce health-related quality of life (QOL) and physical functioning, creating an urgent need to develop effective, durable, and disseminable interventions. Harvest for Health, a home- ... Full text Link to item Cite

Improving the quality of survivorship for older adults with cancer.

Journal Article Cancer · August 15, 2016 In May 2015, the Cancer and Aging Research Group, in collaboration with the National Cancer Institute and the National Institute on Aging through a U13 grant, convened a conference to identify research priorities to help design and implement intervention s ... Full text Link to item Cite

Validation of a Prediction Tool for Chemotherapy Toxicity in Older Adults With Cancer.

Journal Article J Clin Oncol · July 10, 2016 PURPOSE: Older adults are at increased risk for chemotherapy toxicity, and standard oncology assessment measures cannot identify those at risk. A predictive model for chemotherapy toxicity was developed (N = 500) that consisted of geriatric assessment ques ... Full text Link to item Cite

Comorbidity in older adults with cancer.

Journal Article J Geriatr Oncol · July 2016 Comorbidity is an issue of growing importance due to changing demographics and the increasing number of adults over the age of 65 with cancer. The best approach to the clinical management and decision-making in older adults with comorbid conditions remains ... Full text Link to item Cite

Geriatric assessment with management in cancer care: Current evidence and potential mechanisms for future research.

Journal Article J Geriatr Oncol · July 2016 Older adults with cancer represent a complex patient population. Geriatric assessment (GA) is recommended to evaluate the medical and supportive care needs of this group. "GA with management" is a term encompassing the resultant medical decisions and inter ... Full text Link to item Cite

Interventions to improve the quality of life and survivorship of older adults with cancer: The funding landscape at NIH, ACS and PCORI.

Journal Article J Geriatr Oncol · July 2016 Identifying knowledge gaps and research opportunities in cancer and aging research was the focus of a three-part conference series led by the Cancer and Aging Research Group from 2010 to 2015. The third meeting, featured representatives from the NIA, NCI, ... Full text Link to item Cite

A pooled analysis of concurrent chemoradiotherapy (CCRT) for patients with stage III non-small cell lung cancer (NSCLC) who participated in U.S. cooperative group trials: Comparing the outcomes of elderly to younger patients (pts).

Conference Journal of Clinical Oncology · May 20, 2016 Full text Cite

Accrual of older patients (pts) with breast cancer to Alliance systemic therapy trials over time: A151527.

Conference Journal of Clinical Oncology · May 20, 2016 Full text Cite

Reply to N. Lowy et al and to J. Dhanda et al.

Journal Article J Clin Oncol · May 10, 2016 Full text Link to item Cite

Automated versus manual data extraction of venous thromboembolism risk among hospitalized older adults

Conference Journal of the American Geriatrics Society, Special Issue 2016: Annual Scientific Meeting Abstract Book · April 22, 2016 Full text Link to item Cite

Chemotherapeutic treatment issues in the elderly

Chapter · April 19, 2016 Cite

Effects of Religious Versus Conventional Cognitive-Behavioral Therapy on Gratitude in Major Depression and Chronic Medical Illness: A Randomized Clinical Trial

Journal Article Journal of Spirituality in Mental Health · April 2, 2016 This study examined whether religiously-integrated cognitive behavioral therapy (RCBT) was more effective than conventional CBT (CCBT) on generating gratitude among religious persons with major depressive disorder (MDD) and chronic medical illness (CMI). P ... Full text Cite

Social support and its implications in older, early-stage breast cancer patients in CALGB 49907 (Alliance A171301).

Journal Article Psychooncology · April 2016 BACKGROUND: Studies point to a direct association between social support and better cancer outcomes. This study examined whether baseline social support is associated with better survival and fewer chemotherapy-related adverse events in older, early-stage ... Full text Link to item Cite

Physical Resilience in Older Adults: Systematic Review and Development of an Emerging Construct.

Journal Article J Gerontol A Biol Sci Med Sci · April 2016 BACKGROUND: Resilience has been described in the psychosocial literature as the capacity to maintain or regain well-being during or after adversity. Physical resilience is a newer concept that is highly relevant to successful aging. Our objective was to ch ... Full text Link to item Cite

Renal Toxicity Associated with Salsalate in Elderly Adults with Anemia.

Journal Article J Am Geriatr Soc · April 2016 Full text Link to item Cite

Endothelial Progenitor Cell Levels Predict Future Physical Function: An Exploratory Analysis From the VA Enhanced Fitness Study.

Journal Article J Gerontol A Biol Sci Med Sci · March 2016 BACKGROUND: Levels of circulating progenitor cells (CPCs) are depleted with aging and chronic injury and are associated with level of physical functioning; however, little is known about the correlation of CPCs with longer-term measures of physical capabil ... Full text Link to item Cite

Effect of Pretreatment Renal Function on Treatment and Clinical Outcomes in the Adjuvant Treatment of Older Women With Breast Cancer: Alliance A171201, an Ancillary Study of CALGB/CTSU 49907.

Journal Article J Clin Oncol · March 1, 2016 PURPOSE: CALGB 49907 showed the superiority of standard therapy, which included either cyclophosphamide/doxorubicin (AC) or cyclophosphamide/methotrexate/fluorouracil over single-agent capecitabine in the treatment of patients age ≥ 65 with early-stage bre ... Full text Link to item Cite

Religious Involvement and Adaptation in Female Family Caregivers.

Journal Article J Am Geriatr Soc · March 2016 OBJECTIVES: To examine the relationship between religious involvement (RI) and adaptation of women caring for family members with severe physical or neurological disability. DESIGN: Two-site cross-sectional study. SETTING: Community. PARTICIPANTS: A conven ... Full text Link to item Cite

A Novel Analytic Technique to Measure Associations Between Circulating Biomarkers and Physical Performance Across the Adult Life Span.

Journal Article J Gerontol A Biol Sci Med Sci · February 2016 Understanding associations between circulating biomarkers and physical performance across the adult life span could aid in better describing mechanistic pathways leading to disability. We hypothesized that high concentrations of circulating biomarkers woul ... Full text Link to item Cite

Preface.

Journal Article Clin Geriatr Med · February 2016 Full text Link to item Cite

Effects of religious vs. standard cognitive behavioral therapy on therapeutic alliance: A randomized clinical trial.

Journal Article Psychother Res · 2016 BACKGROUND: Treatments that integrate religious clients' beliefs into therapy may enhance the therapeutic alliance (TA) in religious clients. OBJECTIVE: Compare the effects of religiously integrated cognitive behavioral therapy (RCBT) and standard CBT (SCB ... Full text Link to item Cite

Religious Involvement and Telomere Length in Women Family Caregivers.

Journal Article J Nerv Ment Dis · January 2016 Telomere length (TL) is an indicator of cellular aging associated with longevity and psychosocial stress. We examine here the relationship between religious involvement and TL in 251 stressed female family caregivers recruited into a 2-site study. Religiou ... Full text Link to item Cite

Association of Co-Existing Impairments in Cognition and Self-Rated Vision and Hearing With Health Outcomes in Older Adults.

Journal Article Gerontol Geriatr Med · 2016 OBJECTIVES: To assess the relationship of disability (activities of daily living (ADL) and instrumental ADL (IADL)), self-rated health (SRH), and 6-year mortality with co-existing impairments in vision (self-rated), hearing (self-rated) and/or cognition (S ... Full text Link to item Cite

Group trajectory analysis helps to identify older cancer survivors who benefit from distance-based lifestyle interventions.

Journal Article Cancer · December 15, 2015 BACKGROUND: The number of older cancer survivors is increasing as more adults survive to older ages. The objectives of this study were to examine trajectories of physical activity (PA) and physical function (PF) over a 2-year lifestyle counseling study and ... Full text Link to item Cite

Advancing Geriatrics Education Through a Faculty Development Program for Geriatrics-Oriented Clinician Educators.

Journal Article J Am Geriatr Soc · December 2015 Geriatrician and nongeriatrician faculty need instruction as teachers to provide quality training for a broader community of physicians who can care for the expanding population of older adults. Educators at Duke University designed a program to equip geri ... Full text Open Access Link to item Cite

Correspondence.

Journal Article J Public Health (Oxf) · December 2015 Full text Link to item Cite

Improving the Evidence Base for Treating Older Adults With Cancer: American Society of Clinical Oncology Statement.

Journal Article J Clin Oncol · November 10, 2015 The American Society of Clinical Oncology (ASCO) convened a subcommittee to develop recommendations on improving the evidence base for treating older adults with cancer in response to a critical need identified by the Institute of Medicine. Older adults ex ... Full text Link to item Cite

Baseline Prostate Atrophy is Associated with Reduced Risk of Prostate Cancer in Men Undergoing Repeat Prostate Biopsy.

Journal Article J Urol · November 2015 PURPOSE: We evaluated whether the presence and severity of baseline prostate atrophy in men with initial biopsy negative for prostate cancer was associated the risk of subsequent prostate cancer detection in a clinical trial with scheduled study mandated b ... Full text Link to item Cite

Validation of survival prognostic models for non-small-cell lung cancer in stage- and age-specific groups.

Journal Article Lung Cancer · November 2015 PURPOSE: Prognostic models have been proposed to predict survival for non-small-cell lung cancer (NSCLC). It is important to evaluate whether these models perform better than performance status (PS) alone in stage- and age-specific subgroups. PATIENTS AND ... Full text Link to item Cite

Symptoms, weight loss, and physical function in a lifestyle intervention study of older cancer survivors.

Journal Article J Geriatr Oncol · November 2015 OBJECTIVES: Many older cancer survivors are overweight or obese, with additional illness burden increasing functional decline, which may affect their ability to engage in lifestyle interventions. This study examined how overweight long-term survivors' symp ... Full text Link to item Cite

Erratum: An accidental career in geriatrics (Journal of the American Geriatrics Society (2015) (1946))

Journal Article Journal of the American Geriatrics Society · November 1, 2015 Full text Cite

Anemia and Functional Disability in Older Adults With Cancer.

Journal Article J Natl Compr Canc Netw · October 2015 OBJECTIVES: Anemia is associated with functional disability among older adults in general. However, the relationship between anemia and functional disability has not been well characterized among older adults with cancer. Therefore, we examined the associa ... Full text Link to item Cite

An Accidental Career in Geriatrics.

Journal Article J Am Geriatr Soc · September 2015 Full text Link to item Cite

Postoperative Cognitive Dysfunction: Minding the Gaps in Our Knowledge of a Common Postoperative Complication in the Elderly.

Journal Article Anesthesiol Clin · September 2015 Postoperative cognitive dysfunction (POCD) is a common complication associated with significant morbidity and mortality in elderly patients. There is much interest in and controversy about POCD, reflected partly in the increasing number of articles publish ... Full text Link to item Cite

Quantification of biological aging in young adults.

Journal Article Proc Natl Acad Sci U S A · July 28, 2015 Antiaging therapies show promise in model organism research. Translation to humans is needed to address the challenges of an aging global population. Interventions to slow human aging will need to be applied to still-young individuals. However, most human ... Full text Open Access Link to item Cite

Abstract P5-15-07: Association of patient preference for adjuvant chemotherapy (chemo) at baseline (BL) with toxicity, mental health, function, quality of life (QoL) and survival in older women with early stage breast cancer (ESBC) [CALGB 49907 Alliance]

Conference Cancer Research · May 1, 2015 AbstractBackground: In CALGB-49907 (NEJM 2009;360:2055), older patients (pts) with ESBC were randomized to standard adjuvant chemo (AC or CMF versus capecitabine). The objective of this secondary QoL analysi ... Full text Cite

Religious vs. conventional cognitive behavioral therapy for major depression in persons with chronic medical illness: a pilot randomized trial.

Journal Article J Nerv Ment Dis · April 2015 We examine the efficacy of conventional cognitive behavioral therapy (CCBT) versus religiously integrated CBT (RCBT) in persons with major depression and chronic medical illness. Participants were randomized to either CCBT (n = 67) or RCBT (n = 65). The in ... Full text Link to item Cite

Religiously integrated cognitive behavioral therapy: a new method of treatment for major depression in patients with chronic medical illness.

Journal Article Psychotherapy (Chic) · March 2015 Intervention studies have found that psychotherapeutic interventions that explicitly integrate clients' spiritual and religious beliefs in therapy are as effective, if not more so, in reducing depression than those that do not for religious clients. Howeve ... Full text Link to item Cite

Generalizability of trial results to elderly Medicare patients with advanced solid tumors (Alliance 70802).

Journal Article J Natl Cancer Inst · January 2015 BACKGROUND: In the United States, patients who enroll in chemotherapy trials seldom reflect the attributes of the general population with cancer, as they are often younger, more functional, and have less comorbidity. We compared survival following three ch ... Full text Link to item Cite

Effects of religious vs. conventional cognitive-behavioral therapy on generosity in major depression and chronic medical illness: A randomized clinical trial

Journal Article Spirituality in Clinical Practice · 2015 Cite

Associations among survivorship care plans, experiences of survivorship care, and functioning in older breast cancer survivors: CALGB/Alliance 369901.

Journal Article J Cancer Surviv · December 2014 PURPOSE: Survivorship care plans (SCP) are recommended for all cancer patients and could be especially useful to survivors 65 years and over ("older"). This study examined receipt of SCPs among older breast cancer survivors and whether SCPs were associated ... Full text Link to item Cite

A prospective randomized wait list control trial of intravenous iron sucrose in older adults with unexplained anemia and serum ferritin 20-200 ng/mL.

Journal Article Blood Cells Mol Dis · December 2014 Anemia is common in older persons and is associated with substantial morbidity and mortality. One third of anemic older adults have unexplained anemia of the elderly (UAE). We carried out a randomized, wait list control trial in outpatients with UAE and se ... Full text Link to item Cite

Perinatal complications and aging indicators by midlife.

Journal Article Pediatrics · November 2014 BACKGROUND: Perinatal complications predict increased risk for morbidity and early mortality. Evidence of perinatal programming of adult mortality raises the question of what mechanisms embed this long-term effect. We tested a hypothesis related to the the ... Full text Link to item Cite

Introduction

Chapter · October 9, 2014 Cite

Palliative care is critical to the changing face of child mortality and morbidity in the United States.

Journal Article Clin Pediatr (Phila) · October 2014 Full text Link to item Cite

Comorbidity, chemotherapy toxicity, and outcomes among older women receiving adjuvant chemotherapy for breast cancer on a clinical trial: CALGB 49907 and CALGB 361004 (alliance).

Journal Article J Oncol Pract · September 2014 PURPOSE: We evaluated associations among comorbidity, toxicity, time to relapse (TTR), and overall survival (OS) in older women with early-stage breast cancer receiving adjuvant chemotherapy. METHODS: Cancer and Leukemia Group B 49907 (Alliance) randomly a ... Full text Link to item Cite

Designing therapeutic clinical trials for older and frail adults with cancer: U13 conference recommendations.

Journal Article J Clin Oncol · August 20, 2014 A majority of cancer diagnoses and deaths occur in patients age ≥ 65 years. With the aging of the US population, the number of older adults with cancer will grow. Although the coming wave of older patients with cancer was anticipated in the early 1980s, wh ... Full text Link to item Cite

Incorporating biomarkers into cancer and aging research.

Journal Article J Clin Oncol · August 20, 2014 The challenge in treating the older adult with cancer is accurately accounting for and adapting management to the heterogeneity in health status of the individual patient. Many oncologists recognize that chronological age alone should not be the determinan ... Full text Link to item Cite

Religious involvement is associated with greater purpose, optimism, generosity and gratitude in persons with major depression and chronic medical illness.

Journal Article J Psychosom Res · August 2014 OBJECTIVE: Religious involvement may help individuals with chronic medical illness cope better with physical disability and other life changes. We examine the relationships between religiosity, depressive symptoms, and positive emotions in persons with maj ... Full text Link to item Cite

Frailty and adherence to adjuvant hormonal therapy in older women with breast cancer: CALGB protocol 369901.

Journal Article J Clin Oncol · August 1, 2014 PURPOSE: Most patients with breast cancer age ≥ 65 years (ie, older patients) are eligible for adjuvant hormonal therapy, but use is not universal. We examined the influence of frailty on hormonal therapy noninitiation and discontinuation. PATIENTS AND MET ... Full text Link to item Cite

Light-intensity activity attenuates functional decline in older cancer survivors.

Journal Article Med Sci Sports Exerc · July 2014 UNLABELLED: While moderate- to vigorous-intensity physical activities (MVPA) confer the greatest health benefits, evidence suggests that light-intensity activities are also beneficial, particularly for older adults and individuals with moderate to severe c ... Full text Link to item Cite

Inflammation and Coagulation as Mediators in the Relationships Between Religious Attendance and Functional Limitations in Older Adults.

Journal Article J Aging Health · June 2014 OBJECTIVE: The aim of this study was to examine inflammation and coagulation, which are positively linked to disability and inversely linked to increased religious attendance, as mediators in the cross-sectional relationships between religious attendance a ... Full text Link to item Cite

Multiple myeloma in the very old: an IASIA conference report.

Journal Article J Natl Cancer Inst · April 3, 2014 Multiple myeloma (MM) in patients aged greater than 80 years poses an increasingly common challenge for oncology providers. A multidisciplinary workshop was held in which MM-focused hematologists/oncologists, geriatricians, and associated health-care team ... Full text Link to item Cite

Characteristics and treatment options of elderly Chinese patients with cancer as determined by Comprehensive Geriatric Assessment (CGA).

Journal Article J Geriatr Oncol · April 2014 OBJECTIVE: China is experiencing a rapid increase in cancer incidence in elderly patients. In order to better understand this group, a large study of patients from multiple tertiary centers in the Beijing area was designed. This study was designed to provi ... Full text Link to item Cite

Reply to L.K. Mell et al.

Journal Article J Clin Oncol · April 1, 2014 Full text Link to item Cite

Underrepresentation of older adults in cancer trials--reply.

Journal Article JAMA · March 5, 2014 Full text Link to item Cite

The Duke Center for the Study of Aging: one of our earliest roots.

Journal Article Gerontologist · February 2014 The Duke University Center for the Study of Aging and Human Development (Duke CFA) was established by a multidisciplinary group of visionary scientists in 1955. It is the oldest continually operating center or institute dedicated to aging in the United Sta ... Full text Link to item Cite

Senior adult oncology, version 2.2014: clinical practice guidelines in oncology .

Journal Article J Natl Compr Canc Netw · January 2014 Cancer is the leading cause of death in older adults aged 60 to 79 years. The biology of certain cancers and responsiveness to therapy changes with the patient's age. Advanced age alone should not preclude the use of effective treatment that could improve ... Full text Link to item Cite

Accelerated aging among cancer survivors: from pediatrics to geriatrics.

Journal Article Am Soc Clin Oncol Educ Book · 2014 There are almost 14-million cancer survivors in the United States and the population is growing. Almost two-thirds of these survivors are age 65 or older. Given this, it is imperative to understand the impact of cancer and its therapies on the aging proces ... Full text Link to item Cite

Lower levels of circulating progenitor cells are associated with low physical function and performance in elderly men with impaired glucose tolerance: a pilot substudy from the VA Enhanced Fitness trial.

Journal Article J Gerontol A Biol Sci Med Sci · December 2013 BACKGROUND: Aging is marked by a decline in physical function. Although the biological underpinnings for this remain unclear, loss of regenerative capacity has been proposed as one cause of the loss of physical function that occurs over time. The quantity ... Full text Link to item Cite

Improving the quality of cancer care in an aging population: recommendations from an IOM report.

Journal Article JAMA · November 6, 2013 Full text Link to item Cite

End points and trial design in geriatric oncology research: a joint European organisation for research and treatment of cancer--Alliance for Clinical Trials in Oncology--International Society Of Geriatric Oncology position article.

Journal Article J Clin Oncol · October 10, 2013 Selecting the most appropriate end points for clinical trials is important to assess the value of new treatment strategies. Well-established end points for clinical research exist in oncology but may not be as relevant to the older cancer population becaus ... Full text Link to item Cite

A planned, prospective comparison of short-term quality of life outcomes among older patients with breast cancer treated with standard chemotherapy in a randomized clinical trial vs. an observational study: CALGB #49907 and #369901.

Journal Article J Geriatr Oncol · October 2013 OBJECTIVES: Patients ≥ 65 years old ("older") are often not included in randomized clinical trials (RCT), but when they are, care in an RCT might improve quality of life (QoL). We conducted a prospective comparison of QoL among older women receiving standa ... Full text Link to item Cite

A low-vision rehabilitation program for patients with mild cognitive deficits.

Journal Article JAMA Ophthalmol · July 2013 IMPORTANCE: We are unaware of any standardized protocols within low-vision rehabilitation (LVR) to address cognitive impairment. OBJECTIVE: To design and pilot-test an LVR program for patients with macular disease and cognitive deficits. DESIGN: The Memory ... Full text Link to item Cite

Trajectory classes of body mass index in a representative elderly community sample.

Journal Article J Gerontol A Biol Sci Med Sci · June 2013 BACKGROUND: It is unclear whether distinct weight-related trajectory classes, differing in course, demographics, and health characteristics, exist in the elderly population. METHODS: Data came from the 10-year (1986-1996) Duke Established Populations for E ... Full text Link to item Cite

Cognitive function in older women with breast cancer treated with standard chemotherapy and capecitabine on Cancer and Leukemia Group B 49907.

Journal Article Breast Cancer Res Treat · June 2013 Cognitive changes in older women receiving chemotherapy are poorly understood. We examined self-reported cognitive function for older women who received adjuvant chemotherapy on Cancer and Leukemia Group B (CALGB) 49907. CALGB 49907 randomized 633 women ag ... Full text Link to item Cite

Multidisciplinary Models of Care

Journal Article · January 2, 2013 Full text Cite

Depletion of circulating progenitor cells precedes overt diabetes: a substudy from the VA enhanced fitness trial.

Journal Article J Diabetes Complications · 2013 BACKGROUND: One theory of aging and disease development is that chronic injury (pathology) results in activation of regenerative processes and initial repair, with overt disease arising only after exhaustion of reparative capability leads to inadequate rep ... Full text Link to item Cite

Persistence, adherence, and toxicity with oral CMF in older women with early-stage breast cancer (Adherence Companion Study 60104 for CALGB 49907).

Journal Article Ann Oncol · December 2012 BACKGROUND: Cyclophosphamide-methotrexate-5-fluorouracil (CMF) is often selected as adjuvant chemotherapy for older patients with early-stage breast cancer due to perceived superior tolerability. We sought to measure persistence with CMF, adherence to oral ... Full text Link to item Cite

Memory deficit associated with worse functional trajectories in older adults in low-vision rehabilitation for macular disease.

Journal Article J Am Geriatr Soc · November 2012 OBJECTIVES: To examine whether performance on a brief memory test is related to functional outcomes in older individuals undergoing low-vision rehabilitation (LVR) for macular disease. DESIGN: Observational cohort study of individuals receiving outpatient ... Full text Link to item Cite

MEDICARE-BASED MULTIMORBIDITY INDEX FOR PROJECTING MORBIDITY AND MORTALITY AMONG OLDER ADULTS IN THE U.S

Journal Article GERONTOLOGIST · November 1, 2012 Open Access Link to item Cite

Role of pain medications, consultants, and other services in improved pain control of elderly adults with cancer in geriatric evaluation and management units.

Journal Article J Am Geriatr Soc · October 2012 OBJECTIVES: To determine whether pain medication use and inpatient consultations and services were associated with significantly better pain control. DESIGN: Secondary data analysis from a randomized two-by-two factorial trial. Hospitalized, frail individu ... Full text Link to item Cite

Patient and physician decision styles and breast cancer chemotherapy use in older women: Cancer and Leukemia Group B protocol 369901.

Journal Article J Clin Oncol · July 20, 2012 PURPOSE Physician and patient decision styles may influence breast cancer care for patients ≥ 65 years ("older") because there is uncertainty about chemotherapy benefits in this group. We evaluate associations between decision-making styles and actual trea ... Full text Link to item Cite

Reach out to enhance wellness home-based diet-exercise intervention promotes reproducible and sustainable long-term improvements in health behaviors, body weight, and physical functioning in older, overweight/obese cancer survivors.

Journal Article J Clin Oncol · July 1, 2012 PURPOSE: Diet and exercise interventions have been tested in cancer survivors as a means to reduce late effects and comorbidity, but few have assessed adherence and health outcomes long term. METHODS: Between July 2005 and May 2007, the Reach Out to Enhanc ... Full text Link to item Cite

Dietary patterns differ between urban and rural older, long-term survivors of breast, prostate, and colorectal cancer and are associated with body mass index.

Journal Article J Acad Nutr Diet · June 2012 BACKGROUND: Older adult cancer survivors are at greater risk of cancer recurrence and other comorbidities that can be prevented through improved diet and weight management. The tertiary prevention needs of rural-dwelling survivors can be even greater, yet ... Full text Link to item Cite

Comorbidity, chemotherapy toxicity, and outcomes among older women receiving adjuvant chemotherapy for breast cancer (BC)

Conference JOURNAL OF CLINICAL ONCOLOGY · May 20, 2012 Link to item Cite

The Donald W. Reynolds Consortium for Faculty Development to Advance Geriatrics Education (FD~AGE): a model for dissemination of subspecialty educational expertise.

Journal Article Acad Med · May 2012 PURPOSE: Most U.S. medical schools and training programs lack sufficient faculty expertise in geriatrics to train future physicians to care for the growing population of older adults. Thus, to reach clinician-educators at institutions and programs that hav ... Full text Link to item Cite

Biological, clinical, and psychosocial correlates at the interface of cancer and aging research.

Journal Article J Natl Cancer Inst · April 18, 2012 In September 2010, the Cancer and Aging Research Group, in collaboration with the National Cancer Institute and the National Institute on Aging, conducted the first of three planned conferences to discuss research methodology to generate the highest qualit ... Full text Link to item Cite

Impact of age, comorbidity and symptoms on physical function in long-term breast cancer survivors (CALGB 70803).

Journal Article J Geriatr Oncol · April 1, 2012 PURPOSE: The purpose of this study was to assess the impact of aging, comorbidities and symptoms on physical function in patients surviving 20 years since adjuvant treatment for breast cancer. PATIENTS #ENTITYSTARTX00026; METHODS: Patients were originally ... Full text Link to item Cite

Higher medical morbidity burden is associated with external locus of control.

Journal Article J Am Geriatr Soc · April 2012 OBJECTIVES: To describe the association between an increasing number of coexisting conditions and locus of control (LOC), a psychological construct reflecting the degree to which one perceives circumstances to be controlled by personal actions (internal LO ... Full text Link to item Cite

Medical causes of dementia, Part II: Metabolic, organ related, nutritional, toxic, and psychiatric

Chapter · March 28, 2012 Cite

Paclitaxel efficacy and toxicity in older women with metastatic breast cancer: combined analysis of CALGB 9342 and 9840.

Journal Article Ann Oncol · March 2012 BACKGROUND: Two Cancer and Leukemia Group B (CALGB) studies were utilized to determine the efficacy and tolerability of paclitaxel (Taxol) in older patients with metastatic breast cancer. PATIENTS AND METHODS: CALGB 9840 evaluated weekly paclitaxel (80 mg/ ... Full text Link to item Cite

Senior adult oncology.

Journal Article J Natl Compr Canc Netw · February 2012 Full text Link to item Cite

Geriatric inpatient units in the care of hospitalized frail adults with a history of heart failure

Journal Article International Journal of Gerontology · January 1, 2012 Background: Frail hospitalized older adults are at risk for adverse outcomes. Previous studies have suggested benefits for inpatient geriatric management (GEM). We sought to determine whether hospitalized patients with a history of heart failure (HF) benef ... Full text Cite

Relations of a marker of endothelial activation (s-VCAM) to function and mortality in community-dwelling older adults.

Journal Article J Gerontol A Biol Sci Med Sci · December 2011 BACKGROUND: We wished to determine if a marker of endothelial dysfunction/activation soluble vascular cell adhesion molecule (s-VCAM)-was related to functional status and mortality in community-dwelling older adults independent of the known effects of mark ... Full text Link to item Cite

Categorizing the effect of comorbidity: a qualitative study of individuals' experiences in a low-vision rehabilitation program.

Journal Article J Am Geriatr Soc · October 2011 OBJECTIVES: To identify generalizable ways that comorbidity affects older adults' experiences in a health service program directed toward an index condition and to develop a framework to assist clinicians in approaching comorbidity in the design, delivery, ... Full text Link to item Cite

Black-white disparity in disability: the role of medical conditions.

Journal Article J Am Geriatr Soc · May 2011 OBJECTIVES: To describe the independent contributions of selected medical conditions to the disparity between black and white people in disability rates, controlling for demographic and socioeconomic factors. DESIGN: Cross-sectional analysis of a community ... Full text Link to item Cite

Plasma acylcarnitines are associated with physical performance in elderly men.

Journal Article J Gerontol A Biol Sci Med Sci · May 2011 BACKGROUND: Metabolic profiling might provide insight into the biologic underpinnings of disability in older adults. METHODS: A targeted mass spectrometry-based platform was used to identify and quantify 45 plasma acylcarnitines in 77 older men with a mean ... Full text Link to item Cite

Implementing a geriatric assessment in cooperative group clinical cancer trials: CALGB 360401.

Journal Article J Clin Oncol · April 1, 2011 PURPOSE: Factors captured in a geriatric assessment can predict morbidity and mortality in older adults, but are not routinely measured in cancer clinical trials. This study evaluated the implementation of a geriatric assessment tool in the cooperative gro ... Full text Link to item Cite

Quality of life of older patients with early-stage breast cancer receiving adjuvant chemotherapy: a companion study to cancer and leukemia group B 49907.

Journal Article J Clin Oncol · March 10, 2011 PURPOSE: A phase III trial (Cancer and Leukemia Group B CALGB-49907) was conducted to test whether older patients with early-stage breast cancer would have equivalent relapse-free and overall survival with capecitabine compared with standard chemotherapy. ... Full text Link to item Cite

Comorbid cognitive impairment and functional trajectories in low vision rehabilitation for macular disease.

Journal Article Aging Clin Exp Res · 2011 BACKGROUND AND AIMS: Comorbid cognitive impairment is common among visually impaired older adults. This study investigated whether baseline cognitive status predicts functional trajectories among older adults in low vision rehabilitation (LVR) for macular ... Full text Link to item Cite

Why John wasn't healed by prayer: perspectives across disciplines.

Journal Article Int J Psychiatry Med · 2011 Patients and family members often turn to prayer in response to serious, life-threatening illness. Prayer for a miraculous cure is often the request. While prayer can keep hope alive, it may also promote unrealistic expectations that fuel demands for life- ... Full text Link to item Cite

Urine peptidomic and targeted plasma protein analyses in the diagnosis and monitoring of systemic juvenile idiopathic arthritis

Journal Article Clinical Proteomics · December 1, 2010 Purpose: Systemic juvenile idiopathic arthritis is a chronic pediatric disease. The initial clinical presentation can mimic other pediatric inflammatory conditions, which often leads to significant delays in diagnosis and appropriate therapy. SJIA biomarke ... Full text Cite

Chronic medical conditions and the sex-based disparity in disability: the Cardiovascular Health Study.

Journal Article J Gerontol A Biol Sci Med Sci · December 2010 BACKGROUND: Older women experience disability more commonly than their male peers. This disparity may be due, in part, to sex-based differences in the prevalence or the disabling effects of common medical conditions. The objectives of this analysis were to ... Full text Link to item Cite

Functional assessment and the cancer survivor: something old, something new.

Journal Article J Natl Cancer Inst · October 6, 2010 Full text Link to item Cite

Accuracy of self-reported height and weight in a community-based sample of older African Americans and whites.

Journal Article J Gerontol A Biol Sci Med Sci · October 2010 BACKGROUND: To ascertain accuracy of self-reported height, weight (and hence body mass index) in African American and white women and men older than 70 years of age. METHOD: The sample consisted of cognitively intact participants at the third in-person wav ... Full text Link to item Cite

The need for an aging and cancer curriculum for hematology/oncology trainees

Journal Article Journal of Geriatric Oncology · October 1, 2010 Purpose: There has long been recognition for the need of education and training in aging and cancer. As the proportion of older individuals in the United States increases, with 20% being over 65 by 2030, it will become increasingly important for hematology ... Full text Cite

Low birth weight is associated with components of the metabolic syndrome.

Journal Article Metabolism · September 2010 The purpose of the study was to investigate the association between birth weight and number of metabolic syndrome (MetS) components in an urban Chinese cohort. Individuals (N = 2019) who were born between 1921 and 1954 at the Peking Union Medical College H ... Full text Link to item Cite

Breast cancer adjuvant chemotherapy decisions in older women: the role of patient preference and interactions with physicians.

Journal Article J Clin Oncol · July 1, 2010 PURPOSE: Breast cancer chemotherapy decisions in patients > or = 65 years old (older) are complex because of comorbidity, toxicity, and limited data on patient preference. We examined relationships between preferences and chemotherapy use. METHODS: Older w ... Full text Link to item Cite

Geriatric oncology research in the cooperative groups: A report of a SIOG special meeting

Journal Article Journal of Geriatric Oncology · June 1, 2010 Purpose: The purpose of this meeting was to bring together geriatric oncology researchers in the cooperative groups to discuss the design of clinical trials to improve our knowledge of the efficacy and toxicity of cancer therapeutics in older adults with c ... Full text Cite

The Link Between Religion and Health: Psychoneuroimmunology and the Faith Factor

Book · April 1, 2010 This book presents new medical research establishing a connection between religion and health and examines the implications for Eastern and Western religious traditions and for society and culture. It examines a series of psychoneuroimmunology (PNI) topics ... Full text Cite

Avenues for Future Research

Chapter · April 1, 2010 This chapter explores avenues for future research in the area of religion, spirituality and psychoneuroimmunology. Recommendations are made based in part on a recent conference at Duke University Medical Center that brought together the world's leading exp ... Full text Cite

Psychological Stress and Autoimmune Disease

Chapter · April 1, 2010 This chapter looks at diseases which result not from a hypoactive immune system but rather from an immune system functioning in an exaggerated or uncontrolled fashion. This is seen in autoimmune diseases such as psoriasis, rheumatoid arthritis, Graves's di ... Full text Cite

Psychosocial Factors, Immunity, and Wound Healing

Chapter · April 1, 2010 This chapter reviews the work of Janice Kiecolt-Glaser, Ron Glaser and others who have investigated the effects of psychological stress and social support on immune functioning and wound healing. This area of research is of particular importance because of ... Full text Cite

Introduction

Journal Article The Link Between Religion and Health: Psychoneuroimmunology and the Faith Factor · April 1, 2010 On July 12 1999, twelve of the world's leading psychoneuroimmunologists, theologians and physicians gathered at Duke University to discuss the effects of stress on the immune system and to see how this knowledge might inform us about the religion-health re ... Full text Cite

Long-term results of Dana-Farber Cancer Institute ALL Consortium protocols for children with newly diagnosed acute lymphoblastic leukemia (1985-2000).

Journal Article Leukemia · February 2010 The Dana-Farber Cancer Institute (DFCI) acute lymphoblastic leukemia (ALL) Consortium has been conducting multi-institutional clinical trials in childhood ALL since 1981. The treatment backbone has included 20-30 consecutive weeks of asparaginase during in ... Full text Link to item Cite

Erwinia asparaginase after allergy to E. coli asparaginase in children with acute lymphoblastic leukemia.

Journal Article Pediatr Blood Cancer · February 2010 BACKGROUND: Escherichia coli asparaginase is an important component of treatment for childhood acute lymphoblastic leukemia (ALL); however, hypersensitivity develops in up to 30% of patients. We assessed the nadir enzyme activity and tolerability of Erwini ... Full text Link to item Cite

Geriatric assessment for the older adult with cancer

Chapter · January 1, 2010 The aging population in the United States and worldwide Cancer is a disease associated with aging. Approximately 60 percent of cancer incidence and 70 percent of cancer mortality occur in adults over 65 years of age.1 Thus the principles of geriatrics are ... Full text Cite

Practical geriatric oncology

Book · January 1, 2010 The risk of cancer increases with age, and the number of older adults seeking treatment is increasing dramatically in line with the aging population. The care of older patients differs from that of younger adults because of differences in the biology of th ... Full text Cite

Prevalence and patterns of comorbid cognitive impairment in low vision rehabilitation for macular disease.

Journal Article Arch Gerontol Geriatr · 2010 The prevalence of comorbid cognitive impairment among older adults referred to low vision rehabilitation (LVR) for macular disease is unknown. We performed cognitive testing on 101 adults aged 65 years or older with macular disease who were referred to The ... Full text Link to item Cite

Promoting healthy lifestyles in older cancer survivors to improve health and preserve function.

Journal Article J Am Geriatr Soc · November 2009 Currently, there are about 7 million cancer survivors in this country aged 65 and older, and this number is expected to increase rapidly, given trends toward aging and improvements in early detection and treatment. Unfortunately, cancer survivors are at ri ... Full text Link to item Cite

A model for the shared care of elderly patients with cancer.

Journal Article J Am Geriatr Soc · November 2009 A model of care for elderly patients with cancer is suggested that incorporates the concept of shared care by various disciplines but in particular the oncologist and primary care provider or geriatrician. Degrees of participation will vary over time, depe ... Full text Link to item Cite

Associations between lifestyle factors and quality of life among older long-term breast, prostate, and colorectal cancer survivors.

Journal Article Cancer · September 1, 2009 BACKGROUND: Older cancer survivors are at increased risk for secondary cancers, cardiovascular disease, obesity, and functional decline and, thus, may benefit from health-related interventions. However, to the authors' knowledge, little is known regarding ... Full text Link to item Cite

Adjuvant chemotherapy in older women with early-stage breast cancer.

Journal Article N Engl J Med · May 14, 2009 BACKGROUND: Older women with breast cancer are underrepresented in clinical trials, and data on the effects of adjuvant chemotherapy in such patients are scant. We tested for the noninferiority of capecitabine as compared with standard chemotherapy in wome ... Full text Link to item Cite

Effects of home-based diet and exercise on functional outcomes among older, overweight long-term cancer survivors: RENEW: a randomized controlled trial.

Journal Article JAMA · May 13, 2009 CONTEXT: Five-year survival rates for early stage colorectal, breast, and prostate cancer currently exceed 90% and are increasing. Cancer survivors are at greater risk for second malignancies, other comorbidities, and accelerated functional decline. Lifest ... Full text Link to item Cite

Reach out to ENhancE Wellness in Older Cancer Survivors (RENEW): design, methods and recruitment challenges of a home-based exercise and diet intervention to improve physical function among long-term survivors of breast, prostate, and colorectal cancer.

Journal Article Psychooncology · April 2009 OBJECTIVE: Cure rates for cancer are increasing, especially for breast, prostate, and colorectal cancer. Despite positive trends in survivorship, a cancer diagnosis can trigger accelerated functional decline that can threaten independence, reduce quality-o ... Full text Link to item Cite

Correlation between symptoms and function in older adults with comorbidity.

Journal Article J Am Geriatr Soc · April 2009 OBJECTIVES: To describe the relationship between symptom scores and mobility function measures, assess whether symptom scores and disease scores are similarly associated with mobility function, and identify clusters of symptoms that are most strongly assoc ... Full text Link to item Cite

Differential gene expression of interleukin-1 receptor associated kinase-1 and interleukin-1 receptor associated kinase-M in peripheral blood mononuclear cells of young and aged rats following preconditioning with endotoxin.

Journal Article Shock · January 2009 The IL-1 receptor-associated kinase 1 (IRAK-1) and IRAK-M are key signaling molecules in cellular responses to endotoxin initiated through the Toll-like receptors (TLRs). The aim of this study was to evaluate the effect of age on the modulation of TLRs and ... Full text Link to item Cite

Physical activity as a preventative factor for frailty: the health, aging, and body composition study.

Journal Article J Gerontol A Biol Sci Med Sci · January 2009 BACKGROUND: It is unclear if physical activity (PA) can prevent or reverse frailty. We examined different doses and types of PA and their association with the onset and severity of frailty. METHODS: Health, Aging and Body Composition (Health ABC) study par ... Full text Link to item Cite

Fatigue in older cancer patients: etiology, assessment, and treatment.

Journal Article Semin Oncol · December 2008 Cancer-related fatigue (CRF) is one of the most common and debilitating symptoms experienced by elderly cancer patients and by cancer survivors. However, this has not translated into an increase in clinical trials for assessment and therapy of CRF in this ... Full text Link to item Cite

Overturning barriers will take heavy lifting

Journal Article Journal of Oncology Practice · December 1, 2008 Full text Cite

New light on an age-old issue.

Journal Article Mech Ageing Dev · November 2008 In this issue, Varadhan and colleagues propose a methodologic framework that seeks to quantify impaired resiliency in dynamic systems underlying the frailty syndrome. We view this work, which is based on modeling stimulus-response data, as an exciting expa ... Full text Link to item Cite

Effect of physical activity guidelines on physical function in older adults.

Journal Article J Am Geriatr Soc · October 2008 OBJECTIVES: To determine whether elderly people who meet national guidelines have higher physical function (PF) scores than those who do not and the effect on functional trajectory when physical activity (PA) levels change from above to below this threshol ... Full text Link to item Cite

Dietary supplement use among elderly, long-term cancer survivors.

Journal Article J Cancer Surviv · September 2008 INTRODUCTION: The purpose of the present study was to assess dietary supplement use and its association with micronutrient intakes and diet quality among older (>or=65 years), long-term survivors (>or=5 years post-diagnosis) of female breast, prostate, and ... Full text Link to item Cite

Capture of phosphopeptides using alpha-zirconium phosphate nanoplatelets.

Journal Article Anal Chem · July 15, 2008 Alpha-zirconium phosphate nanoplatelets (alpha-ZrPN) were studied as a binding agent for phosphopeptides. Nanoplatelets of alpha-zirconium phosphate were incubated overnight with zirconium oxychloride, followed by centrifugation, and washed twice with wate ... Full text Link to item Cite

The older cancer patient.

Journal Article Nurs Clin North Am · June 2008 Providing effective and tolerable cancer treatment for the growing number of older adult patients who have cancer requires an understanding of the role of aging, comorbidity, functional status, and frailty on treatment outcomes. The incorporation of compre ... Full text Link to item Cite

Evidence of a relationship between infant birth weight and later diabetes and impaired glucose regulation in a Chinese population.

Journal Article Diabetes Care · March 2008 OBJECTIVE: The aim of this study was to determine the influence of birth weight, a marker of fetal growth, on the development of later impaired glucose metabolism throughout the life span of people living in China. RESEARCH DESIGN AND METHODS: We recorded ... Full text Link to item Cite

Geographical segregation and IL-6: a marker of chronic inflammation in older adults.

Journal Article Biomark Med · 2008 AIM: To examine environmental sociodemographic risks of high IL-6, a marker of chronic inflammation in older adults. METHODS: We spatially linked 1990 USA Census tract demographic and economic measures to a prospective cohort study of representative commun ... Full text Link to item Cite

Effect of telephone exercise counseling on frailty in older veterans: project LIFE.

Journal Article Am J Mens Health · December 2007 This study sought to determine if telephone exercise counseling attenuates frailty in older, male veterans through increased levels of physical activity. Eighty-one elderly, male veterans (age = 78.4 +/- 4.9 years) randomized to intervention (n = 39) or co ... Full text Link to item Cite

Application of assessing care of vulnerable elders-3 quality indicators to patients with advanced dementia and poor prognosis.

Journal Article J Am Geriatr Soc · October 2007 OBJECTIVES: To use a formal decision-making strategy to reach clinically appropriate, internally consistent decisions on the application of quality indicators (QIs) to vulnerable elders (VEs) with advanced dementia (AD) or poor prognosis (PP). DESIGN: Usin ... Full text Link to item Cite

The Diet Quality Index-Revised: a tool to promote and evaluate dietary change among older cancer survivors enrolled in a home-based intervention trial.

Journal Article J Am Diet Assoc · September 2007 OBJECTIVE: To utilize the Diet Quality Index-Revised (DQI-R) as a framework for delivering and evaluating an intervention to improve overall diet quality among older cancer survivors. DESIGN: As part of a randomized controlled trial to improve lifestyle be ... Full text Link to item Cite

Frailty thy name is ... Phrailty?

Journal Article J Gerontol A Biol Sci Med Sci · July 2007 Featured Publication Full text Link to item Cite

Evaluation of agreement between physicians' notation of 'no evidence of disease' (NED) and patients' report of cancer status.

Journal Article Psychooncology · July 2007 This study examines extent of agreement between oncologists' and cancer patients' reports of current cancer status. Participants with history of cancer were given a comprehensive geriatric assessment in which they were asked whether they had cancer at the ... Full text Link to item Cite

The combined effect of visual impairment and cognitive impairment on disability in older people.

Journal Article J Am Geriatr Soc · June 2007 OBJECTIVES: To determine the risk of disability in individuals with coexisting visual and cognitive impairment and to compare the magnitude of risk associated with visual impairment, cognitive impairment, or the multimorbidity. DESIGN: Prospective cohort. ... Full text Link to item Cite

Meeting report: Translational Research at the Aging and Cancer Interface.

Journal Article Cancer Res · May 15, 2007 Full text Link to item Cite

The cancer aging interface: a research agenda.

Journal Article J Clin Oncol · May 10, 2007 Featured Publication There are substantial knowledge gaps in our understanding of the relationships between cancer and aging. These include areas of basic biology, societal aspects, and clinical aspects. Recommendations for research agendas in each of these areas are offered. ... Full text Link to item Cite

Report of the national institute on aging task force on comorbidity.

Journal Article J Gerontol A Biol Sci Med Sci · March 2007 The National Institute on Aging (NIA) Geriatrics and Clinical Gerontology (GCG) Program convened an interdisciplinary Task Force on Comorbidity to foster the development of a research agenda on the multiple concurrent health problems that often occur in ol ... Full text Link to item Cite

Anemia and cancer in older persons.

Journal Article J Support Oncol · March 2007 Although the overall prevalence for many cancers is declining, cancer still remains a diagnosis more common in the elderly than in younger individuals. As the population ages, the proportion of patients with cancer who are elderly is expected to increase d ... Link to item Cite

Effect of motorized scooters on physical performance and mobility: a randomized clinical trial.

Journal Article Arch Phys Med Rehabil · March 2007 OBJECTIVE: To investigate the effects of providing a motorized scooter on physical performance and mobility. DESIGN: Randomized clinical trial comparing scooter users with usual care. SETTING: One academic and 1 Veterans Affairs medical center. PARTICIPANT ... Full text Link to item Cite

Biological and clinical significance of monoclonal gammopathy

Chapter · January 1, 2007 Introduction: Monoclonal gammopathy of unknown significance (MGUS) affects up to 2% of persons aged 50 years or over, and about 3% of those older than 70 years. The aim of this chapter is to highlight some of the features of this disease process and its re ... Full text Cite

Hematologic disorders

Chapter · January 1, 2007 Full text Cite

Monitoring the randomized trials of the Women's Health Initiative: the experience of the Data and Safety Monitoring Board.

Journal Article Clin Trials · 2007 Data Safety Monitoring Committees (DSMB) for large, long-term randomized trials of agents in common use face challenging problems especially when the emerging data indicate unanticipated effects. The DSMB for the Women's Health Initiative Clinical Trials, ... Full text Link to item Cite

Combination of flavor enhancement and chemosensory education improves nutritional status in older cancer patients.

Journal Article J Nutr Health Aging · 2007 BACKGROUND: Abnormalities in taste and smell functioning occur with elevated frequency in both older adults and patients with cancer. With the predicted increase in both of these populations in the coming decades, it is imperative to evaluate potential int ... Link to item Cite

Effect of cancer screening and desirable health behaviors on functional status, self-rated health, health service use and mortality.

Journal Article J Am Geriatr Soc · January 2007 OBJECTIVES: To determine whether some health behaviors of older people (e.g., obtaining cancer screens) have a limited and others (e.g., exercise) have a broad association with population-level health status 4 to 6 years later. DESIGN: Longitudinal cohort. ... Full text Link to item Cite

Telephone monitoring of distress in patients aged 65 years or older with advanced stage cancer: a cancer and leukemia group B study.

Journal Article Cancer · December 1, 2006 BACKGROUND: Significant barriers to cancer patients receiving mental health treatment for distress have been reported in the literature. The objective of the current study was to determine whether distress in older patients (aged 65 years and older) would ... Full text Link to item Cite

Keynote comment: cancer survivorship and ageing--a double whammy.

Journal Article Lancet Oncol · November 2006 Featured Publication Full text Link to item Cite

Spirituality across the lifespan.

Journal Article South Med J · October 2006 Full text Link to item Cite

Geriatric assessment for oncologists: rationale and future directions.

Journal Article Crit Rev Oncol Hematol · September 2006 Sixty percent of all cancer occurrences and seventy percent of cancer mortalities occur in people over the age of 65. As the population ages, there is an emerging need to develop a means for oncologists to characterize the "functional age" of older patient ... Full text Link to item Cite

The older cancer patient.

Journal Article Med Clin North Am · September 2006 Providing effective and tolerable cancer treatment for the growing number of older adult patients who have cancer will require an understanding of the role of aging, comorbidity, functional status, and frailty on treatment outcomes. The incorporation of CG ... Full text Link to item Cite

Lifestyle intervention development study to improve physical function in older adults with cancer: outcomes from Project LEAD.

Journal Article J Clin Oncol · July 20, 2006 PURPOSE: Declines in physical functioning (PF) among elderly cancer patients threaten quality of life and the ability to maintain independence. Adherence to healthy lifestyle behaviors may prevent functional decline. PATIENTS AND METHODS: Project Leading t ... Full text Link to item Cite

Prevalence of monoclonal gammopathy of undetermined significance.

Journal Article N Engl J Med · June 29, 2006 Full text Link to item Cite

The cancer and leukemia group B cancer in the elderly committee: addressing a major cancer need.

Journal Article Clin Cancer Res · June 1, 2006 Cancer is a disease of aging, and the majority of cancers occur in persons over 65 years of age. In spite of this, few elders have been represented in clinical trials, and the need for information regarding the treatment of elders with cancer remains great ... Full text Link to item Cite

Impact of anemia on mortality, cognition, and function in community-dwelling elderly.

Journal Article Am J Med · April 2006 Featured Publication PURPOSE: To explore the impact of varying hemoglobin levels on mortality, function, and cognition in a representative population of older persons. METHODS: Participants in this prospective cohort study included 1 744 men and women, aged 71 years or older, ... Full text Link to item Cite

The effect of geriatrics evaluation and management on nursing home use and health care costs: results from a randomized trial.

Journal Article Med Care · January 2006 Featured Publication BACKGROUND: The Geriatric Evaluation and Management study was developed to assess the impact of a comprehensive geriatric assessment service on the care of the elderly. OBJECTIVES: We sought to evaluate the cost and clinical impact of inpatient units and o ... Full text Link to item Cite

Is the prevalence of dehydration among community-dwelling older adults really low? Informing current debate over the fluid recommendation for adults aged 70+years.

Journal Article Public Health Nutr · December 2005 OBJECTIVE: The fluid recommendation for adults aged 70+ years has been criticised on the basis of a low prevalence of dehydration in community-dwelling older adults. This study explores whether the low prevalence might reflect limitations of individual deh ... Full text Link to item Cite

In reply [10]

Journal Article Journal of Clinical Oncology · December 1, 2005 Full text Cite

Developing a cancer-specific geriatric assessment: a feasibility study.

Journal Article Cancer · November 1, 2005 Featured Publication BACKGROUND: As the U.S. population ages, there is an emerging need to characterize the "functional age" of older patients with cancer to tailor treatment decisions and stratify outcomes based on factors other than chronologic age. The goals of the current ... Full text Link to item Cite

The association between oral health and general health and quality of life in older male cancer patients.

Journal Article J Am Geriatr Soc · September 2005 OBJECTIVES: To describe the long-term effects of oral health problems on quality of life (QoL), functional status, pain, and general health in older male cancer patients. DESIGN: Secondary analysis of a prospective observational study. SETTING: Community d ... Full text Link to item Cite

Use of comprehensive geriatric assessment in older cancer patients: recommendations from the task force on CGA of the International Society of Geriatric Oncology (SIOG).

Journal Article Crit Rev Oncol Hematol · September 2005 BACKGROUND: As more and more cancers occur in elderly people, oncologists are increasingly confronted with the necessity of integrating geriatric parameters in the treatment of their patients. METHODS: The International Society of Geriatric Oncology (SIOG) ... Full text Link to item Cite

Senior adult oncology clinical practice guidelines in oncology.

Journal Article J Natl Compr Canc Netw · July 2005 Full text Link to item Cite

Geriatric evaluation and management units in the care of the frail elderly cancer patient.

Journal Article J Gerontol A Biol Sci Med Sci · June 2005 Featured Publication BACKGROUND: Geriatric assessment has been suggested as a possibly useful approach in dealing with frail elderly cancer patients. METHODS: This was a secondary subset analysis from a randomized 2 x 2 factorial trial in 11 Department of Veterans Affairs medi ... Full text Link to item Cite

Approach to monoclonal gammopathy of unknown significance in the older patient

Journal Article Clinical Geriatrics · June 1, 2005 Cite

Improving accrual of older persons to cancer treatment trials: a randomized trial comparing an educational intervention with standard information: CALGB 360001.

Journal Article J Clin Oncol · April 1, 2005 PURPOSE: To design and test a geriatric educational intervention to improve accrual of cancer patients age 65 years and older to cooperative group-sponsored treatment trials. METHODS: Main member institutions of the Cancer and Leukemia Group B (CALGB) and ... Full text Link to item Cite

Adjuvant chemotherapy in older and younger women with lymph node-positive breast cancer.

Journal Article JAMA · March 2, 2005 CONTEXT: Adjuvant chemotherapy improves survival for patients with local-regional breast cancer, but healthy older patients at high risk of recurrence are frequently not offered adjuvant chemotherapy, and the benefit of adjuvant chemotherapy in older patie ... Full text Link to item Cite

Never too old? Age should not be a barrier to enrollment in cancer clinical trials.

Journal Article Oncologist · March 2005 Throughout Europe and the U.S., over 60% of the total incidence of cancer occurs in the elderly (> or =65 years) population, a patient group that requires particular consideration when making treatment decisions due to a number of factors. Despite this, el ... Full text Link to item Cite

Walking speed predicts health status and hospital costs for frail elderly male veterans.

Journal Article J Rehabil Res Dev · 2005 This study evaluated the use of walking speed as an indicator of function and health status in acutely ill, hospitalized, older male veterans. Hospital inpatients in a Department of Veterans Affairs (VA) study of Geriatric Evaluation and Management (GEM) ( ... Full text Link to item Cite

Perspectives, preferences, care practices, and outcomes among older and middle-aged patients with late-stage cancer.

Journal Article J Clin Oncol · December 15, 2004 PURPOSE: To evaluate relationships among physician and cancer patient survival estimates, patients' perceived quality of life, care preferences, and outcomes, and how they vary across middle-aged and older patient groups. PATIENTS AND METHODS: Subjects wer ... Full text Link to item Cite

The Impact of Anemia on Mortality, Cognition and Function in a Racially Diverse Community-Dwelling Elderly Population.

Conference Blood · November 16, 2004 AbstractThe WHO definition of anemia, Hgb<12g/dL (W) and <13g/dL (M) is largely based on studies in younger populations. As our population is aging it is important to explore the impact of varying Hgb ... Full text Cite

Effects of cancer history and comorbid conditions on mortality and healthcare use among older cancer survivors.

Journal Article Cancer · November 15, 2004 BACKGROUND: Older cancer survivors use healthcare services to an increased extent relative to their counterparts who have no history of malignant disease. In the current study, the authors set out to assess the effects of cancer history and comorbid condit ... Full text Link to item Cite

Physical function and associations with diet and exercise: Results of a cross-sectional survey among elders with breast or prostate cancer.

Journal Article Int J Behav Nutr Phys Act · October 29, 2004 BACKGROUND: Functional decline threatens independent living and is common among individuals diagnosed with cancer, especially those who are elderly. The purpose of this study was to explore whether dietary and exercise practices are associated with physica ... Full text Open Access Link to item Cite

Inpatient care for elderly cancer patients: the role for Geriatric Evaluation and Management Units in fulfilling goals for care.

Journal Article Crit Rev Oncol Hematol · September 2004 PURPOSE: To describe patterns of functional status, symptoms, therapeutic goals and outcomes among older adults with cancer diagnoses hospitalized on a Geriatric Evaluation and Management Unit (GEMU). DESIGN AND METHODS: Retrospective chart review of veter ... Full text Link to item Cite

Plasma hypertonicity: another marker of frailty?

Journal Article J Am Geriatr Soc · August 2004 OBJECTIVES: To determine whether plasma hypertonicity might be a marker of early frailty, this study tested the associations between plasma hypertonicity, incident disability, and mortality in nondisabled older adults. DESIGN: Longitudinal, observational s ... Full text Link to item Cite

Duke University School of Medicine.

Journal Article Acad Med · July 2004 Full text Link to item Cite

Aging and cancer.

Journal Article Clin Adv Hematol Oncol · July 2004 A substantial increase in the number of elderly people in the populations of developed nations in the coming years has been projected. Persons 65 years and older are at significantly higher risk of developing cancer when compared to younger individuals. Th ... Link to item Cite

Geriatric assessment and comorbidity.

Journal Article Semin Oncol · April 2004 Elderly persons, a rapidly growing population segment, have an increased incidence of cancer. The older cancer patient's clinical evaluation and treatment is influenced by conditions such as disabilities, comorbidity, and functional status, along with tumo ... Full text Link to item Cite

Effects of geriatric evaluation and management on adverse drug reactions and suboptimal prescribing in the frail elderly.

Journal Article Am J Med · March 15, 2004 Featured Publication PURPOSE: To determine if inpatient or outpatient geriatric evaluation and management, as compared with usual care, reduces adverse drug reactions and suboptimal prescribing in frail elderly patients. METHODS: The study employed a randomized 2 x 2 factorial ... Full text Link to item Cite

Symptom management in the elderly cancer patient: fatigue, pain, and depression.

Journal Article J Natl Cancer Inst Monogr · 2004 Patients who are > or =65 years of age are the fastest growing segment of the U.S. population. These patients with already existing physiologic decline and comorbidities, when diagnosed with cancer, provide considerable challenges in management issues. Alo ... Full text Link to item Cite

Hypertonic hyperglycemia progresses to diabetes faster than normotonic hyperglycemia.

Journal Article Eur J Epidemiol · 2004 To explore whether elevated plasma glucose might progress to diabetes via a mechanism that involves plasma hypertonicity, we evaluated the independent and joint effects of these variables on diabetes risk. Community-dwelling older adults (70+years), who re ... Full text Link to item Cite

Function in elderly cancer survivors depends on comorbidities.

Journal Article J Gerontol A Biol Sci Med Sci · December 2003 Featured Publication BACKGROUND: Factors associated with functional status in elderly cancer survivors, in particular, comorbidity, have been inadequately studied. METHODS: Of 4162 participants aged 65 and older enrolled in the Duke Established Populations for Epidemiologic St ... Full text Link to item Cite

Cancer in the elderly: to screen or not to screen?

Journal Article J Am Geriatr Soc · December 2003 Full text Link to item Cite

The above letter was referred to the author(s) of the original paper and their reply follows

Journal Article Journal of the American Geriatrics Society · December 2003 Full text Cite

The origin of the word geriatrics.

Journal Article J Am Geriatr Soc · November 2003 Full text Link to item Cite

Cross-linked fibrin degradation products (D-dimer), plasma cytokines, and cognitive decline in community-dwelling elderly persons.

Journal Article J Am Geriatr Soc · October 2003 Featured Publication OBJECTIVES: To investigate the effect of coagulation and inflammatory pathway activation on future cognitive decline in older persons. DESIGN: Prospective cohort study. SETTING: Rural and urban communities in North Carolina. PARTICIPANTS: Community-dwellin ... Full text Link to item Cite

An overview of variance inflation factors for sample-size calculation.

Journal Article Eval Health Prof · September 2003 For power and sample-size calculations, most practicing researchers rely on power and sample-size software programs to design their studies. There are many factors that affect the statistical power that, in many situations, go beyond the coverage of commer ... Full text Link to item Cite

Barriers to clinical trial participation by older women with breast cancer.

Journal Article J Clin Oncol · June 15, 2003 PURPOSE: Although 48% of breast cancer patients are 65 years old or older, these older patients are severely underrepresented in breast cancer clinical trials. This study tested whether older patients were offered trials significantly less often than young ... Full text Link to item Cite

Leading the Way in Exercise and Diet (Project LEAD): intervening to improve function among older breast and prostate cancer survivors.

Journal Article Control Clin Trials · April 2003 The U.S. population is aging, bringing with it an increased prevalence of chronic disease and concomitant declines in physical function. The risk of developing cancer increases significantly with age, and functional decline is much more likely once a cance ... Full text Link to item Cite

Anemia in the elderly: clinical impact and practical diagnosis.

Journal Article J Am Geriatr Soc · March 2003 Full text Link to item Cite

Coagulation and activation of inflammatory pathways in the development of functional decline and mortality in the elderly.

Journal Article Am J Med · February 15, 2003 Featured Publication PURPOSE: This study was performed to determine the effects of markers of inflammation (interleukin 6) and coagulation (D-dimer) on mortality and functional status in older persons. METHODS: Subjects were selected for the Duke Established Populations for Ep ... Full text Link to item Cite

Cytokines and cognition--the case for a head-to-toe inflammatory paradigm.

Journal Article J Am Geriatr Soc · December 2002 The brain is not only immunologically active of its own accord, but also has complex peripheral immune interactions. Given the central role of cytokines in neuroimmmunoendocrine processes, it is hypothesized that these molecules influence cognition via div ... Full text Link to item Cite

The effect of comorbid illness on receipt of cancer screening by older people.

Journal Article J Am Geriatr Soc · October 2002 OBJECTIVES: To identify associations between the type and number of diagnoses and receipt of screening for breast, cervical, and colorectal cancer by older people. DESIGN: Sixth annual follow-up of a community-based survey with 4,162 participants aged 65 a ... Full text Link to item Cite

Survey of oncologists' perceptions of barriers to accrual of older patients with breast carcinoma to clinical trials.

Journal Article Cancer · September 1, 2002 BACKGROUND: Prior research has documented the under-representation in clinical trials of older patients with cancer. In part of a larger study to test the magnitude of these barriers to entering eligible older patients with carcinoma of the breast into cli ... Full text Link to item Cite

Functional status and the elderly cancer patient.

Journal Article Crit Rev Oncol Hematol · September 2002 Evaluation of functional status plays a unique role in the assessment of older cancer patients. While performance status has been the traditional method for oncologists to assess the impact of a cancer patient's disease, older cancer patients may require a ... Full text Link to item Cite

A controlled trial of geriatric evaluation.

Journal Article N Engl J Med · August 1, 2002 Full text Link to item Cite

Analysis of age, estimated creatinine clearance and pretreatment hematologic parameters as predictors of fludarabine toxicity in patients treated for chronic lymphocytic leukemia: a CALGB (9011) coordinated intergroup study.

Journal Article Cancer Chemother Pharmacol · July 2002 PURPOSE: Fludarabine is a renally excreted agent that is an effective treatment for chronic lymphocytic leukemia (CLL), a disease predominantly of the elderly. We sought to determine whether age, renal function or pretreatment hematologic status predicted ... Full text Link to item Cite

A controlled trial of inpatient and outpatient geriatric evaluation and management.

Journal Article N Engl J Med · March 21, 2002 Featured Publication BACKGROUND: Over the past 20 years, both inpatient units and outpatient clinics have developed programs for geriatric evaluation and management. However, the effects of these interventions on survival and functional status remain uncertain. METHODS: We con ... Full text Link to item Cite

Comprehensive assessment of the elderly cancer patient: the feasibility of self-report methodology.

Journal Article J Clin Oncol · February 1, 2002 Featured Publication PURPOSE: Comprehensive geriatric assessment (CGA) has aided the medical community greatly in understanding the quality-of-life issues and functional needs of older patients. With its professional team assessment approach, however, CGA may be time consuming ... Full text Link to item Cite

Inpatient geriatric units and outpatient geriatric clinics improve quality of life, but not survival for frail older adults

Journal Article Evidence-Based Healthcare · January 1, 2002 Full text Cite

Comparison of methods for detecting potential adverse drug events in frail elderly inpatients and outpatients.

Journal Article Am J Health Syst Pharm · September 1, 2001 Full text Link to item Cite

Accuracy of self-reported stroke among elderly veterans.

Journal Article Aging Ment Health · August 2001 The objective was to use secondary analysis of prevalence data from a prospective cohort study to ascertain the accuracy of self-reported stroke among veterans. The study comprised a community-dwelling population of 88 elderly veterans (from five counties ... Full text Link to item Cite

Cancer screening in the elderly.

Journal Article Hosp Pract (1995) · March 15, 2001 A number of disease- and patient-specific factors need to be taken into account when cancer screening is considered in an older patient. They include the impact of aging on the cancer's biology and screening test performance, the patient's remaining years ... Full text Link to item Cite

Considerations of psychosocial illness phase in cancer survival.

Journal Article Psychooncology · 2001 Rarely are biomedical, clinical and psychosocial data considered simultaneously as influences on cancer patient outcomes. This study utilized medical record and interview data from 152 adult cancer patients with various tumor types in a model of survival e ... Full text Link to item Cite

In search of the underlying mechanisms of frailty.

Journal Article J Gerontol A Biol Sci Med Sci · December 2000 Featured Publication Full text Link to item Cite

The Lichtman/Skirvin article reviewed

Journal Article ONCOLOGY · December 1, 2000 Cite

Age, functional status, and racial differences in plasma D-dimer levels in community-dwelling elderly persons.

Journal Article J Gerontol A Biol Sci Med Sci · November 2000 BACKGROUND: Dysregulation of immunologic and coagulation systems is common in elderly persons and is associated with many diseases of aging. Thrombotic events are a major cause of morbidity and mortality in the elderly population. This study assesses wheth ... Full text Link to item Cite

Generalists and oncologists show similar care practices and outcomes for hospitalized late-stage cancer patients. SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks for Treatment.

Journal Article Med Care · November 2000 OBJECTIVE: The objective of this work was to identify similarities and differences in primary attending physicians' (generalists' versus oncologists') care practices and outcomes for seriously ill hospitalized patients with malignancy. DESIGN: This was a p ... Full text Link to item Cite

Antihypertensive drugs and gastrointestinal hemorrhage: causation or confounding?

Journal Article Gastroenterology · November 2000 Full text Link to item Cite

Racial differences in use of cancer prevention services among older Americans.

Journal Article J Am Geriatr Soc · July 2000 CONTEXT: Racial differences in receipt of cancer prevention services may be related to poorer outcomes for minorities. Understanding reasons for such differences could help target appropriate interventions. OBJECTIVES: To determine if racial differences ex ... Full text Link to item Cite

Age differences in care practices and outcomes for hospitalized patients with cancer.

Journal Article J Am Geriatr Soc · May 2000 OBJECTIVE: To identify age group differences in care practices and outcomes for seriously ill hospitalized patients with malignancy. DESIGN: Prospective cohort study (SUPPORT project). SETTING: Five United States teaching hospitals; data was gathered betwe ... Full text Link to item Cite

Calcium channel blockers and cancer.

Journal Article Am J Med · February 15, 2000 PURPOSE: We sought to explore the relation that has been previously reported between calcium channel blockers and an increased risk of cancer. SUBJECTS AND METHODS: We followed 3,511 participants, age 65 years or older, in the Duke Established Populations ... Full text Link to item Cite

Clinical research in the older cancer patient.

Journal Article Hematol Oncol Clin North Am · February 2000 The opportunities for conducting focused research in older patients with cancer continue to increase and reflect the increasing awareness of the incidence of cancer in older persons. As the population ages, cancer will become more and more a problem of the ... Full text Link to item Cite

Comorbidity of five chronic health conditions in elderly community residents: determinants and impact on mortality.

Journal Article J Gerontol A Biol Sci Med Sci · February 2000 BACKGROUND: Comorbidity is common in elderly persons. Its extent, correlates, and life-threatening impact in representative community residents are unclear. METHODS: Self-reported information of physician-diagnosed coronary artery disease (CAD), cerebrovas ... Full text Link to item Cite

Does religious attendance prolong survival? A six-year follow-up study of 3,968 older adults.

Journal Article J Gerontol A Biol Sci Med Sci · July 1999 METHODS: A probability sample of 3,968 community-dwelling adults aged 64-101 years residing in the Piedmont of North Carolina was surveyed in 1986 as part of the Established Populations for the Epidemiologic Studies of the Elderly (EPESE) program of the Na ... Full text Link to item Cite

Serum IL-6 level and the development of disability in older persons.

Journal Article J Am Geriatr Soc · June 1999 Featured Publication BACKGROUND: The serum concentration of interleukin 6 (IL-6), a cytokine that plays a central role in inflammation, increases with age. Because inflammation is a component of many age-associated chronic diseases, which often cause disability, high circulati ... Full text Link to item Cite

Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly.

Journal Article Am J Med · May 1999 PURPOSE: To investigate whether interleukin-6 and C-reactive protein levels predict all-cause and cause-specific mortality in a population-based sample of nondisabled older people. SUBJECTS AND METHODS: A sample of 1,293 healthy, nondisabled participants i ... Full text Link to item Cite

Evidence for a black-white crossover in all-cause and coronary heart disease mortality in an older population: the North Carolina EPESE.

Journal Article Am J Public Health · March 1999 OBJECTIVES: This cohort study evaluated racial differences in mortality among Blacks and Whites 65 years and older. METHODS: A total of 4136 men and women (1875 Whites and 2261 Blacks) living in North Carolina were interviewed in 1986 and followed up for m ... Full text Link to item Cite

Association of interleukin-6 and other biologic variables with depression in older people living in the community.

Journal Article J Am Geriatr Soc · January 1999 Featured Publication OBJECTIVES: The prevalence of depression increases with age, as does the prevalence of higher levels of the cytokine interleukin-6 (IL-6). This analysis was performed to determine the association between increased levels of this cytokine and depression in ... Full text Link to item Cite

Expression of extracellular glutathione peroxidase in human and mouse gastrointestinal tract.

Journal Article Am J Physiol · December 1998 Extracellular glutathione peroxidase (EGPx) is a glycosylated selenoprotein capable of reducing hydrogen peroxide, organic hydroperoxides, free fatty acid hydroperoxides, and phosphatidylcholine hydroperoxides. We found that human large intestinal explant ... Full text Link to item Cite

Benzodiazepine use and cognitive function among community-dwelling elderly.

Journal Article Clin Pharmacol Ther · December 1998 OBJECTIVE: To evaluate the relation between benzodiazepine use and cognitive function among community-dwelling elderly. METHODS: This prospective cohort study included 2765 self-reporting subjects from the Duke Established Populations for Epidemiologic Stu ... Full text Link to item Cite

The relationship between religious activities and cigarette smoking in older adults.

Journal Article J Gerontol A Biol Sci Med Sci · November 1998 BACKGROUND: The objective of this study was to examine the relationship between religious activities and cigarette smoking in community-dwelling older adults. METHODS: Cigarette smoking and religious activities were assessed in a probability sample of 3968 ... Full text Link to item Cite

Developing a summary measure of medical status.

Journal Article Aging (Milano) · October 1998 Health status surveys and assessments typically obtain detailed information on specific physical health conditions. While such specific details are important, it is frequently also valuable to have a summarized evaluation of medical conditions which can be ... Full text Link to item Cite

Religious activity and depression among community-dwelling elderly persons with cancer: the moderating effect of race.

Journal Article J Gerontol B Psychol Sci Soc Sci · July 1998 OBJECTIVES: Research has been oriented toward elucidating the links between religion and mental health. The purpose of this article is to further our knowledge in this area by examining the effect of religious activity on depressive symptomatology among co ... Full text Link to item Cite

Racial differences in the prevalence of monoclonal gammopathy in a community-based sample of the elderly.

Journal Article Am J Med · May 1998 Featured Publication PURPOSE: To determine if there is an increased prevalence of monoclonal gammopathy in elderly blacks compared with whites, analogous to the difference in incidence of multiple myeloma reported for the two racial groups and to confirm age and gender relatio ... Full text Link to item Cite

The cost-effectiveness of a clinical pharmacist intervention among elderly outpatients

Journal Article Pharmacotherapy · March 1, 1998 We estimated the cost and cost-effectiveness of a clinical pharmacist intervention known to improve the appropriateness of drug prescribing. Elderly veteran outpatients prescribed at least five drugs were randomized to an intervention (105 patients) or con ... Cite

The cost-effectiveness of a clinical pharmacist intervention among elderly outpatients.

Journal Article Pharmacotherapy · 1998 We estimated the cost and cost-effectiveness of a clinical pharmacist intervention known to improve the appropriateness of drug prescribing. Elderly veteran outpatients prescribed at least five drugs were randomized to an intervention (105 patients) or con ... Link to item Cite

The relationship between religious activities and blood pressure in older adults.

Journal Article Int J Psychiatry Med · 1998 OBJECTIVE: To examine the relationship between religious activities and blood pressure in community-dwelling older adults. METHOD: Blood pressure and religious activities were assessed in a probability sample of 3,963 persons age sixty-five years or older ... Full text Link to item Cite

Erratum: Racial differences in the prevalence of monoclonal gammopathy in a community-based sample of the elderly (The American Journal of Medicine (1998) 104 (439-444))

Journal Article American Journal of Medicine · January 1, 1998 Cite

Cancer and the functional status of the elderly.

Journal Article Cancer · November 15, 1997 Full text Link to item Cite

An agenda for clinical research in geriatrics.

Journal Article Cancer · October 1, 1997 The health of the older segment of the population is affected by two types of problems: those that cause death and those that cause disability. Both types need to be studied. All levels of investigation, from basic clinical research to applied health servi ... Link to item Cite

The Oncology Geriatric Education Retreat: commentary and conclusions.

Journal Article Cancer · October 1, 1997 The aging of the population will result in more older people with cancer. Thus, it is important to consider mechanisms by which geriatrics content could be incorporated into oncology training. The Oncology Geriatric Education Retreat was held February 21-2 ... Link to item Cite

The association of plasma IL-6 levels with functional disability in community-dwelling elderly.

Journal Article J Gerontol A Biol Sci Med Sci · July 1997 Featured Publication BACKGROUND: IL-6 is a multifunctional cytokine that has been shown to increase with age. METHODS: Plasma IL-6 was measured by ELISA in 1,727 community-dwelling elderly subjects whose blood was drawn during the third in-person survey of the Duke Established ... Full text Link to item Cite

Alterations in stimulus-induced integrin expression in peripheral blood neutrophils of patients with diabetic retinopathy.

Journal Article Am J Med Sci · March 1997 Adhesion molecule expression on peripheral blood leukocytes from diabetic patients with severe retinopathy and age-matched control subjects was assessed. Expression of CD11b, CD18, and L-selectin was measured on granulocytes and lymphocytes in whole blood ... Full text Link to item Cite

Relation of prescription nonsteroidal antiinflammatory drug use to cognitive function among community-dwelling elderly.

Journal Article Ann Epidemiol · February 1997 PURPOSE: To evaluate the relationship of nonsteroidal antiinflammatory drug (NSAID) use to level of cognitive function in community-dwelling elderly persons. METHODS: The prospective cohort study included 2765 nonproxy subjects from the Duke University Est ... Full text Link to item Cite

Attendance at religious services, interleukin-6, and other biological parameters of immune function in older adults.

Journal Article Int J Psychiatry Med · 1997 OBJECTIVE: First, to examine and explain the relationship between religious service attendance and plasma Interleukin-6 (IL-6) levels, and second, to examine the relationship between religious attendance and other immune-system regulators and inflammatory ... Full text Link to item Cite

Race and myeloma survival.

Journal Article J Clin Oncol · December 1996 Full text Link to item Cite

Physician agreement with pharmacist-suggested drug therapy changes for elderly outpatients.

Journal Article Am J Health Syst Pharm · November 15, 1996 Full text Link to item Cite

Medical illness, religion, health control and depression of institutionalized medically ill veterans in long-term care

Journal Article International Journal of Geriatric Psychiatry · July 1, 1996 Utilizing multivariable multivariate regression procedures, we examine the relationships among medical illness, religion, health control beliefs and depression in 97 mostly elderly, institutionalized medically ill veterans in long term-care. Controlling fo ... Full text Cite

Factors predicting change in prescription and nonprescription drug use in a community-residing black and white elderly population.

Journal Article J Clin Epidemiol · May 1996 The current study identifies characteristics that predict change in use of prescription and nonprescription drugs over a period of 3 years. A modified health care services use model was applied to information obtained from a probability-based sample of bla ... Full text Link to item Cite

Is medication use by community-dwelling elderly people influenced by cognitive function?

Journal Article Age Ageing · May 1996 To determine whether medication use differs by cognitive status among community dwelling elderly, a survey was made of a stratified random sample of 4110 black and white participants, aged 65 or older from the Duke Established Populations for Epidemiologic ... Full text Link to item Cite

A randomized, controlled trial of a clinical pharmacist intervention to improve inappropriate prescribing in elderly outpatients with polypharmacy.

Journal Article Am J Med · April 1996 PURPOSE: To evaluate the effect of sustained clinical pharmacist interventions involving elderly outpatients with polypharmacy and their primary physicians. PATIENTS AND METHODS: Randomized, controlled trial of 208 patients aged 65 years or older with poly ... Full text Link to item Cite

Geriatric oncology.

Journal Article Cancer · March 15, 1996 Full text Link to item Cite

Do older women use estrogen replacement? Data from the Duke Established Populations for Epidemiologic Studies of the Elderly (EPESE).

Journal Article J Am Geriatr Soc · January 1996 OBJECTIVES: The primary purpose of this study was to determine the prevalence of current and past estrogen use among older, community-dwelling, postmenopausal women. The secondary purpose was to describe factors associated with estrogen use in this populat ... Full text Link to item Cite

The duke approach to faculty development in geriatric medicine

Journal Article Educational Gerontology · January 1, 1996 A number of studies have documented that there is an inadequate number of physicians trained in geriatrics in the United States. Over the last 15 years, we have developed a Geriatric Physician Fellowship Program directed at developing academic geriatric ph ... Full text Cite

Nonabandonment: medical ethics.

Journal Article Ann Intern Med · September 15, 1995 Full text Link to item Cite

Nonabandonment: medical ethics.

Journal Article Ann Intern Med · September 15, 1995 Full text Link to item Cite

Geriatric principles of treatment applied to medical oncology: an overview.

Journal Article Semin Oncol · February 1995 Link to item Cite

Tumor necrosis factor, natural killer activity and other measures of immune function and inflammation in elderly men with heart failure.

Journal Article Gerontology · 1995 OBJECTIVE: To determine the status of tumor necrosis factor (TNF) and other measures of immunity and inflammation in chronic heart failure (CHF) in the elderly. DESIGN: Comparative survey study of subjects with heart failure and age-matched controls. SETTI ... Full text Link to item Cite

Religious coping and cognitive symptoms of depression in elderly medical patients.

Journal Article Psychosomatics · 1995 The investigators examined associations between depressive symptom type and religious coping in 832 consecutively admitted older medical inpatients. Cognitive symptoms of depression, but not somatic symptoms, were related to religious coping. Boredom, loss ... Full text Link to item Cite

Geriatric principles of treatment applied to medical oncology: An overview

Journal Article Seminars in Oncology · January 1, 1995 Cite

Alterations in L-selectin expression and elastase activity in neutrophils from patients receiving granulocyte colony-stimulating factor alone or in conjunction with high-dose chemotherapy with autologous bone marrow transplantation.

Journal Article Lymphokine Cytokine Res · December 1994 We determined L-selectin expression and elastase levels in neutrophils obtained from patients receiving granulocyte colony-stimulating factor (G-CSF) either alone (given for increasing peripheral progenitor cells for harvest) or in combination with high-do ... Link to item Cite

Variability of plasma IL-6 and crosslinked fibrin dimers over time in community dwelling elderly subjects.

Journal Article Am J Clin Pathol · December 1994 Because obtaining multiple blood samples from individuals involved in epidemiologic studies is difficult, conclusions must be drawn on the basis of one or two samples. In this study, the authors attempted to determine the variability of two plasma markers ... Full text Link to item Cite

Assessing health-related quality of life in elderly outpatients: telephone versus face-to-face administration.

Journal Article J Am Geriatr Soc · December 1994 OBJECTIVE: While health-related quality of life (HRQOL) is increasingly being used as an outcome in clinical trials, it is unknown whether HRQOL assessments are influenced by the method of administration. Within the context of a randomized, controlled tria ... Full text Link to item Cite

Appropriateness of medication prescribing in ambulatory elderly patients.

Journal Article J Am Geriatr Soc · December 1994 OBJECTIVE: To assess the quality of medication prescribing in ambulatory elderly patients on multiple medications using the Medication Appropriateness Index (MAI). DESIGN: Cross-sectional study. SETTING: General Medical Clinic of the Durham VA Medical Cent ... Full text Link to item Cite

Geriatrics faculty and program development at Duke University.

Journal Article Am J Med · October 17, 1994 Full text Link to item Cite

Biology of aging as related to cancer.

Journal Article Cancer · October 1, 1994 The relationship of the biology of aging to cancer in older patients is of importance at several levels. The striking increase of cancer incidence with age may be related to a number of biologic factors. Potential age-related etiologic factors include decr ... Full text Link to item Cite

The comprehensive assessment of community dwelling elderly: why functional status is not enough.

Journal Article Aging (Milano) · October 1994 The present study attempts to determine empirically the relationship of measures of functional status to other domains common to geriatric assessment, and to ascertain whether functional status can substitute for other domains of clinical assessment. A com ... Full text Link to item Cite

A summated score for the medication appropriateness index: development and assessment of clinimetric properties including content validity.

Journal Article J Clin Epidemiol · August 1994 Inappropriate medication prescribing is an important problem in the elderly, but is difficult to measure. As part of a randomized controlled trial to evaluate the effectiveness of a pharmacist intervention among elderly veterans using many medications, we ... Full text Link to item Cite

Age and functional correlations of markers of coagulation and inflammation in the elderly: functional implications of elevated crosslinked fibrin degradation products (D-dimers).

Journal Article J Am Geriatr Soc · July 1994 OBJECTIVE: To measure markers of inflammation in a cohort of young and old subjects and relate these findings to the functional level of the individuals. DESIGN: For the pilot study, blood samples were obtained from 18 young (age 20-35 years) and 18 old (a ... Full text Link to item Cite

Multiple myeloma in the elderly.

Journal Article J Am Geriatr Soc · June 1994 While multiple myeloma is an incurable disease for nearly all patients, current chemotherapy and supportive care can result in significant disease control and improved duration of survival and quality of life. With the average age of patients about 70, mos ... Full text Link to item Cite

Increased adhesion of neutrophils to retinal vascular endothelial cells exposed to hyperosmolarity.

Journal Article Exp Eye Res · June 1994 Recent studies suggest that leukocytes may contribute to capillary occlusion and endothelial cell injury in diabetic retinopathy. The present study is an attempt to determine whether high glucose concentration/hyperosmolar conditions would increase neutrop ... Full text Link to item Cite

Substance P and adrenocorticotropic hormone do not affect T-lymphocyte adhesion to vascular endothelium or surface expression of adhesion receptors.

Journal Article Int J Immunopharmacol · February 1994 Substance P (SP) and adrenocorticotropic hormone (ACTH) are peptides that have been shown to have both neurological and immunological effects. Because of the demonstrated effects upon immune function, we examined the effects of these peptides on T-lymphocy ... Full text Link to item Cite

Geriatrics faculty and program development at Duke University

Journal Article American Journal of Medicine · 1994 Cite

Age-related increase in phorbol myristate acetate-induced lymphocyte adhesion to vascular endothelium.

Journal Article Mech Ageing Dev · November 1993 Lymphocyte adhesion to vascular endothelium is an important part of immune function. This investigation sought to detect differences between the adhesion of lymphocytes from young and aged human donors to vascular endothelium with and without treatment of ... Full text Link to item Cite

Profile of depressive symptoms in younger and older medical inpatients with major depression.

Journal Article J Am Geriatr Soc · November 1993 OBJECTIVE: To examine and compare the profile of cognitive symptoms, somatic symptoms, and somatic complaints in younger and older medical inpatients diagnosed with major depressive disorder (MDD). DESIGN: Cross-sectional cohort. PATIENTS AND SETTING: Male ... Full text Link to item Cite

A fatal case of constrictive pericarditis due to a marked, selective pericardial accumulation of amyloid.

Journal Article Am J Med · March 1993 Distinguishing constrictive pericarditis from restrictive cardiomyopathy, usually due to amyloidosis, is a relatively frequent and difficult diagnostic problem. This report describes, for the first time, a patient with constrictive pericarditis caused by d ... Full text Link to item Cite

A comparative study of monoclonal gammopathies and immunoglobulin levels in Japanese and United States elderly.

Journal Article J Am Geriatr Soc · January 1993 OBJECTIVE: To define the prevalence of monoclonal immunoglobulin (Ig) proteins and quantitative serum immunoglobulin levels in elderly Japanese in comparison with elderly Caucasians as possible factors related to the reported lower incidence of multiple my ... Full text Link to item Cite

Medical education in geriatrics: The lasting impact of the aging game

Journal Article Educational Gerontology · January 1, 1993 In an effort to sensitize medical students to the problems of the frail elderly, a simulation experience known as the Aging Game is a required portion of the In troduction to Clinical Medicine course for medical students at Duke University. The immediate p ... Full text Cite

Predictors of two-year post-hospitalization mortality among elderly veterans in a study evaluating a geriatric consultation team.

Journal Article J Am Geriatr Soc · December 1992 OBJECTIVE: To determine predictors of 2-year post-hospitalization mortality in a cohort of elderly hospitalized patients originally assembled to assess the impact of a Geriatric Consultation Team (GCT). DESIGN: Two-year follow-up of an inception cohort. SE ... Full text Link to item Cite

Religious coping and depression among elderly, hospitalized medically ill men.

Journal Article Am J Psychiatry · December 1992 OBJECTIVE: The investigators examined the frequency of religious coping among older medical inpatients, the characteristics of those who use it, and the relation between this behavior and depression. METHOD: The subjects were 850 men aged 65 years and over ... Full text Link to item Cite

Breast cancer screening in older women: the geriatrician/internist perspective.

Journal Article J Gerontol · November 1992 There are many issues of concern to internists and geriatricians as they face the prospect of implementing breast cancer screening programs for elderly women. Population heterogeneity and variations in comorbidity require individualization in order to maxi ... Link to item Cite

Supporting statements and rationale.

Journal Article J Gerontol · November 1992 Link to item Cite

A method for assessing drug therapy appropriateness.

Journal Article J Clin Epidemiol · October 1992 This study evaluated the reliability of a new medication appropriateness index. Using the index, independent assessments were made of chronic medications taken by 10 ambulatory, elderly male patients by a clinical pharmacist and an internist-geriatrician. ... Full text Link to item Cite

Screening for depression in hospitalized elderly medical patients: taking a closer look.

Journal Article J Am Geriatr Soc · October 1992 OBJECTIVE: To re-examine the test characteristics of the Geriatric Depression Scale (GDS) and the Brief Carroll Depression Rating Scale (BCDRS) in elderly medical inpatients, simulating the procedure followed by clinicians when using screening instruments. ... Full text Link to item Cite

The effect of age on driving skills.

Journal Article J Am Geriatr Soc · June 1992 OBJECTIVE: To assess the effect of age on driving skills independent of the limitations related to disease or dementia. DESIGN: Prospective comparison of driving skills across three age groups. SETTING: A university-based research study of student and univ ... Full text Link to item Cite

Anemia and hemoglobin levels in older persons: relationship with age, gender, and health status.

Journal Article J Am Geriatr Soc · May 1992 OBJECTIVE: To determine the relationship of hemoglobin levels and anemia with age and health status in older adults. DESIGN: Survey. SETTING: Community. PARTICIPANTS AND METHODS: Hematologic tests were obtained from 3,946 adults aged greater than or equal ... Full text Link to item Cite

Flow cytometric analysis of nitric oxide production in human neutrophils using dichlorofluorescein diacetate in the presence of a calmodulin inhibitor.

Journal Article J Leukoc Biol · May 1992 Dichlorofluorescein (DCFH) oxidation assay measures hydrogen peroxide (H2O2), which is a derivative of superoxide anion. We found that a calmodulin antagonist, W-13, which is known to inhibit superoxide anion generation enhanced the capacity of human neutr ... Full text Link to item Cite

Serum albumin in older persons: relationship with age and health status.

Journal Article J Clin Epidemiol · March 1992 We analyzed data from 4115 persons aged 71 years and older who had blood drawn at a home visit in three communities to examine the cross-sectional distribution of serum albumin and correlates of hypoalbuminemia. Mean albumin was lower among older persons, ... Full text Link to item Cite

Age-related alterations in actin cytoskeleton and receptor expression in human leukocytes.

Journal Article J Gerontol · March 1992 We studied a number of parameters, which may all depend upon cytoskeletal function, comparing lymphocytes and granulocytes (PMN) from young and old healthy donors. F-actin content was measured by NBD-phallacidin staining, followed by flow cytometry and was ... Full text Link to item Cite

Changes in actin state and chemotactic peptide receptor expression in granulocytes during cytokine administration after autologous bone marrow transplantation.

Journal Article Lymphokine Cytokine Res · February 1992 We studied the changes in actin state and chemotactic peptide receptor expression in granulocytes from patients receiving different cytokines following high dose chemotherapy and autologous bone marrow transplantation (ABMT). The F-actin content in granulo ... Link to item Cite

Can screening older patients for cancer save lives?

Journal Article Clin Geriatr Med · February 1992 Cancer screening of the elderly is warranted for those cancers for which early detection and treatment improve life expectancy. There is excellent evidence to include screening for breast cancer with clinical examination and mammography for elderly women. ... Link to item Cite

Randomized study of cyclophosphamide, doxorubicin, and vincristine versus etoposide and cisplatin versus alternation of these two regimens in extensive small-cell lung cancer: a phase III trial of the Southeastern Cancer Study Group.

Journal Article J Clin Oncol · February 1992 PURPOSE: The trial was undertaken to determine (1) the relative efficacy/toxicity of two commonly used combination chemotherapy regimens in patients with extensive small-cell lung cancer (SCLC) and (2) whether the rapid alternation of these two regimens co ... Full text Link to item Cite

Cytochalasins induce actin polymerization in human leukocytes.

Journal Article Cell Motil Cytoskeleton · 1992 We studied the effect of cytochalasins (B, D, and E) on the F-actin content in human neutrophils and lymphocytes using NBD-phallacidin labeling followed by flow cytometry. All three cytochalasins induced a concentration- and time-dependent increase in the ... Full text Link to item Cite

A brief depression scale for use in the medically ill.

Journal Article Int J Psychiatry Med · 1992 OBJECTIVE: Using items from two existing depression scales, we have sought to develop a brief self-rated instrument for detecting major depressive disorder (M.D.D.) in medically ill, hospitalized patients. METHOD: Forty-two items from the Geriatric Depress ... Full text Link to item Cite

Self-rated depressive symptoms in medical inpatients: age and racial differences.

Journal Article Int J Psychiatry Med · 1992 One thousand and eleven men under age forty (n = 161) or over age sixty-four (n = 850) admitted to medical and neurological services of an acute care hospital were screened for depressive symptoms as part of the Durham VA Mental Health Survey. Thirty-three ... Full text Link to item Cite

Major depression in hospitalized medically ill older men: Documentation, management, and outcome

Journal Article International Journal of Geriatric Psychiatry · January 1, 1992 Fifty‐three hospitalized elderly men with medical illness were diagnosed with major depressive disorder and followed up for a mean of 2.3 months. Documentation and management of the depression by medical housestaff during the followup period were examined. ... Full text Cite

Working group recommendations: research on content and efficacy of geriatric evaluation and management interventions.

Journal Article J Am Geriatr Soc · September 1991 Methods of conducting comprehensive geriatric evaluation and management (GEM) are proliferating in a variety of clinical settings. However, rigorous evaluations of efficacy for this new approach to care of older patients have demonstrated a favorable impac ... Full text Link to item Cite

Major depressive disorder in hospitalized medically ill patients: an examination of young and elderly male veterans.

Journal Article J Am Geriatr Soc · September 1991 OBJECTIVE: To study the epidemiology of depressive disorder in younger and older medical inpatients. DESIGN, PATIENTS, & SETTING: Depressive disorders were examined using the Diagnostic Interview Schedule in 116 young and 332 elderly medically ill men hosp ... Full text Link to item Cite

My grandmother said, "if you have your health, you have everything." What did she mean?

Journal Article Vital Health Stat 5 · August 1991 Link to item Cite

Cancer mortality, aging, and patterns of comorbidity in the United States: 1968 to 1986.

Journal Article J Gerontol · July 1991 Cancer is often reported as contributing to the risk of noncancer causes of death. The age variation of these reports was studied using U.S. data on all causes of death listed on death certificates for 1968 to 1986. The occurrence of cancer as a nonunderly ... Full text Link to item Cite

Pentoxifylline and other methyl xanthines inhibit interleukin-2 receptor expression in human lymphocytes.

Journal Article Cell Immunol · July 1991 Addition of pentoxifylline to lymphocytes caused a dose-dependent decrease in PHA-induced interleukin-2 receptor (IL-2R) expression. Expression of IL-2R protein and mRNA were inhibited by 60% at a concentration of 1 mM. Pentoxifylline also inhibited releas ... Full text Link to item Cite

An evaluation of a brief health status measure in elderly veterans.

Journal Article J Am Geriatr Soc · July 1991 OBJECTIVE: To examine the feasibility of a brief 36-item health status measure in elderly male veterans, by comparing it with the 136-item Sickness Impact Profile. DESIGN: Cross-sectional study in which all subjects completed both measures in a random orde ... Full text Link to item Cite

Age-related studies of SIg, Leu-4 and concanavalin A receptor densities and capping in human lymphocytes.

Journal Article Mech Ageing Dev · June 28, 1991 We compared the cell surface antigen density and capping of three antigens in lymphocytes obtained from healthy, young (mean age 27 years) and elderly (mean age 76), population. There were no differences in the expression of surface immunoglobulin (SIg), c ... Full text Link to item Cite

Multivariate procedures to describe clinical staging of melanoma.

Journal Article Methods Inf Med · April 1991 Analyzing multivariate clinical data to identify subclasses of patients being treated for a specific disease may improve patient management and increase understanding of the behavior of disease under clinical conditions. In some cases, patients have been c ... Link to item Cite

Anti-inflammatory effects of pentoxifylline in claudication.

Journal Article Am J Med Sci · February 1991 We measured neutrophil elastase/alpha 1 proteinase inhibitor complex (E/alpha) levels by ELISA in plasma samples drawn from 19 patients with claudication, before and at 1 and 2 months after initiation of pentoxifylline (PTF), 400 mg. p.o. tid. Plasma E/alp ... Full text Link to item Cite

Actin cytoskeletal network in aging and cancer.

Journal Article Mutat Res · 1991 The cytoskeleton is being recognized as an important modulator of metabolic functions of the cell. The actin cytoskeletal network, in particular, is involved in events regulating cell proliferation and differentiation. The state of actin in a variety of ce ... Full text Link to item Cite

Commentary

Journal Article Journal of the American Geriatrics Society · January 1, 1991 Full text Cite

The first four years of the Journal of Gerontology: Medical Sciences scientific and ethical challenges

Journal Article Journals of Gerontology · January 1, 1991 Full text Cite

The protein synthetic surge in response to mitogen triggers high glycolytic enzyme levels in human lymphocytes and occurs prior to DNA synthesis.

Journal Article Biochem Med Metab Biol · December 1990 A simultaneous increase is found in the level of protein synthesis and the major regulatory glycolytic enzyme, phosphofructokinase (PFK), in early phytohemagglutinin exposure of human lymphocytes. The induction of DNA synthesis is demonstrated to be a much ... Full text Link to item Cite

Are stressful life events risk factors for herpes zoster?

Journal Article J Am Geriatr Soc · November 1990 To determine if psychologically stressful life events are risk factors for herpes zoster, we conducted a case-control study of zoster and self-reported recent negative life events and major changes in spousal relationships. The subjects were 101 healthy co ... Full text Link to item Cite

Effects of pentoxifylline administration on blood viscosity and leukocyte cytoskeletal function in patients with intermittent claudication.

Journal Article J Lab Clin Med · June 1990 We have previously shown that pentoxifylline, a drug used in intermittent claudication, causes depolymerization of actin in leukocytes in vitro. In this study we evaluated several parameters in peripheral blood obtained from 17 patients receiving pentoxify ... Link to item Cite

Correlation between erythrocyte CR1 reduction and other blood proteinase markers in patients with malignant and inflammatory disorders.

Journal Article Blood · April 15, 1990 Erythrocyte CR1, a C3b/C4b-binding complement-regulatory protein, is sensitive to proteolysis in vitro. To test the hypothesis that in vivo erythrocyte CR1 reduction results from intravascular proteinase activities, we used enzyme-linked immunosorbent assa ... Link to item Cite

Development of multiple monoclonal serum immunoglobulins (multiclonal gammopathy) following both HLA-identical unfractionated and T cell-depleted haploidentical bone marrow transplantation in severe combined immunodeficiency.

Journal Article J Clin Immunol · March 1990 We have identified five patients with severe combined immunodeficiency (SCID) who developed multiple monoclonal serum immunoglobulin components (multiclonal gammopathy) following bone marrow transplantation. Four patients received haploidentical bone marro ... Full text Link to item Cite

Stimulus-specific effects of pentoxifylline on neutrophil CR3 expression, degranulation, and superoxide production.

Journal Article J Leukoc Biol · March 1990 The effects of pentoxifylline (Trental) on human neutrophil CR3 up-modulation, degranulation, and superoxide production were studied. We used the chemotactic peptide fMLP and the phorbol ester PMA as soluble stimuli, and beta-glucan particles as a CR3-spec ... Full text Link to item Cite

Cancer screening in the elderly.

Journal Article J Am Geriatr Soc · March 1990 Full text Link to item Cite

Therapy of acute myelogenous leukemia in patients over the age of 50: a randomized Southeastern Cancer Study Group trial.

Journal Article Leuk Res · 1990 In a randomized trial, 299 evaluable patients with acute myelogenous leukemia, age greater than or equal to 51, were initially randomized to cytosine arabinoside, 100 mg/m2/day, by continuous intravenous infusion for seven days, plus either daunorubicin 45 ... Full text Link to item Cite

The role of the cytoskeleton in aging.

Journal Article Exp Gerontol · 1990 Full text Link to item Cite

An in vitro analogue of immune dysfunction with altered immunoglobulin production in the aged.

Journal Article J Am Geriatr Soc · December 1989 The consequences of aging of the immune system include impaired T-lymphocyte responsiveness and aberrant immunoglobulin production. Although T cells from elderly individuals have a well-described defect in lymphoblastic transformation in response to some p ... Full text Link to item Cite

Comprehensive geriatric assessment: mission not yet accomplished.

Journal Article J Gerontol · November 1989 Full text Link to item Cite

Chemotactic peptide receptor-cytoskeletal interactions and functional correlations in differentiated HL-60 cells and human polymorphonuclear leukocytes.

Journal Article J Cell Physiol · October 1989 We studied the chemotactic peptide receptor/cytoskeletal interactions in HL-60 cells induced to differentiate with different agents and attempted to correlate these observations with the acquisition of different functional responses. Dibutyryl cyclic AMP-t ... Full text Link to item Cite

The 'aging game'. An approach to education in geriatrics.

Journal Article JAMA · September 15, 1989 Full text Link to item Cite

Survival and health care utilization in elderly medical inpatients with major depression.

Journal Article J Am Geriatr Soc · July 1989 Forty-one elderly medical inpatients with active major depression were matched with nondepressed controls from the same population. Survival and health care utilization were examined during a mean follow-up period of five months. Cases and controls were ma ... Full text Link to item Cite

Geriatrics.

Journal Article JAMA · May 19, 1989 Link to item Cite

Hyperviscosity syndrome in association with kappa light chain myeloma.

Journal Article Am J Med · May 1989 Full text Link to item Cite

Familial aggregation of multiple myeloma and central nervous system diseases.

Journal Article J Am Geriatr Soc · April 1989 Degenerative central nervous system diseases such as Alzheimer's disease and lymphoreticular malignancies such as multiple myeloma occur with increased frequency with advancing age. Relatives of early-onset Alzheimer's disease patients may have an increase ... Full text Link to item Cite

Geriatric education: the Duke program.

Journal Article N C Med J · February 1989 Link to item Cite

Geriatrics: Reply

Journal Article Journal of the American Medical Association · 1989 Full text Cite

Age as a prognostic factor in multiple myeloma.

Journal Article Blood · January 1989 Link to item Cite

Health status of aged minorities: directions for clinical research.

Journal Article J Gerontol · January 1989 Full text Link to item Cite

Effect of a geriatric consultation team on functional status of elderly hospitalized patients. A randomized, controlled clinical trial.

Journal Article Ann Intern Med · January 1, 1989 STUDY OBJECTIVE: To evaluate the impact of a geriatric consultation team on the functional status of hospitalized elderly patients. DESIGN: Randomized controlled clinical trial. SETTING: University-affiliated referral Veterans Administration Medical Center ... Full text Link to item Cite

Antidepressant use in elderly medical inpatients: lessons from an attempted clinical trial.

Journal Article J Gen Intern Med · 1989 The authors conducted a clinical trial to examine the efficacy and safety of nortriptyline in the treatment of major depression in elderly medical inpatients. The diagnosis of major depression was made by a psychiatrist in 41 of 680 patients 65 years of ag ... Full text Link to item Cite

Major depression and the NIMH Diagnostic Interview Schedule: validation in medically ill hospitalized patients.

Journal Article Int J Psychiatry Med · 1989 The authors validate the usefulness of the Diagnostic Interview Schedule (DIS) in prevalence studies of major depression (MD) in medically ill male veterans. The affective disorders portion of the DIS was administered by a trained interviewer to a represen ... Full text Link to item Cite

Lack of correlation between induction of chemotactic peptide receptors and stimulus-induced actin polymerization in HL-60 cells treated with dibutyryl cyclic adenosine monophosphate or retinoic acid.

Journal Article Cancer Res · December 1, 1988 We used the promyelocytic leukemic cell line HL-60 to explore the molecular mechanisms regulating stimulus-induced actin polymerization in myeloid cells. HL-60 cells express very few chemotactic peptide receptors in their undifferentiated state and fail to ... Link to item Cite

Actin depolymerization and inhibition of capping induced by pentoxifylline in human lymphocytes and neutrophils.

Journal Article J Cell Physiol · December 1988 Pentoxifylline is used clinically for the treatment of intermittent claudication. It is believed to exert its effect by altering the rheologic properties of blood. The cytoskeleton plays an important role in the maintenance of cell structure and function. ... Full text Link to item Cite

Membrane protein organization of peripheral blood lymphocytes from healthy young and aged adults.

Journal Article Mech Ageing Dev · October 1988 Membrane-mediated events are important in the function of lymphocytes and age-dependent changes in the integrity of lymphocytic membranes could account, in part, for the loss of immune responsiveness observed in the aged. To test the hypothesis that membra ... Full text Link to item Cite

Depression in elderly hospitalized patients with medical illness.

Journal Article Arch Intern Med · September 1988 Depressive symptoms and disorders were identified by structured psychiatric interview in 130 consecutively admitted male inpatients aged 70 years and over. Major depression was found in 11.5% and other depressive syndromes in 23%. While depressive symptoms ... Link to item Cite

Self-rated depression scales and screening for major depression in the older hospitalized patient with medical illness.

Journal Article J Am Geriatr Soc · August 1988 Until now, no self-rated depression scale had been validated as a screening measure for major depression in the older patient hospitalized with medical illness. The present report establishes the validity of two brief, easily administered depression screen ... Full text Link to item Cite

Impact of a geriatric consultation team on discharge placement and repeat hospitalization.

Journal Article Gerontologist · June 1988 Full text Link to item Cite

Cooperative effect of tumor necrosis factor and gamma-interferon on chemotactic peptide receptor expression and stimulus-induced actin polymerization in HL-60 cells.

Journal Article Blood · April 1988 We studied the effect of tumor necrosis factor (TNF) and gamma interferon (IFN-gamma), alone and in combination, on the expression of chemotactic peptide receptors, stimulus-induced actin polymerization, hydrogen peroxide production (H2O2), and expression ... Link to item Cite

Monoclonal gammopathies and aging.

Journal Article Hosp Pract (Off Ed) · March 30, 1988 Link to item Cite

Hospital versus random digit dialing controls in the elderly. Observations from two case-control studies.

Journal Article J Am Geriatr Soc · February 1988 Finding an optimal source of controls is a major consideration in the design of case-control studies. While hospital patients can provide a relatively economical and convenient source of controls, hospital controls may have diseases independently associate ... Full text Link to item Cite

Detection and treatment of major depression in older medically ill hospitalized patients.

Journal Article Int J Psychiatry Med · 1988 While major depression is common among medically ill older inpatients, little is known about the frequency of detection or appropriate treatment in this population. In the present study, 171 consecutive men age seventy and over admitted to the medical and ... Full text Link to item Cite

Monoclonal gammopathies and aging

Journal Article Hospital Practice · January 1, 1988 The monoclonal gammopathies are a group of disorders that are most prevalent in the elderly. Their common denominator is overproduction of a homogeneous immunoglobulin by plasma cells derived from a single ancestral B lymphocyte. The overproduction represe ... Cite

Effects of socioeconomic and clinical factors on survival in multiple myeloma.

Journal Article J Clin Oncol · December 1987 It was recently reported that low socioeconomic status (SES) in multiple myeloma (MM) patients is associated with a poorer prognosis. To reassess this finding in another group of MM patients, we used data from interviews of 153 MM patients seen at Duke Uni ... Full text Link to item Cite

Characteristics of lung cancer in elderly patients.

Journal Article J Gerontol · September 1987 In order to assist in the definition of the natural history of lung cancer in the elderly population, a number of biological characteristics were studied, retrospectively, by comparing previously abstracted data from a cancer registry for three cohorts of ... Full text Link to item Cite

Guidelines for fellowship training programs in geriatric medicine

Journal Article Journal of the American Geriatrics Society · August 1, 1987 Full text Cite

Relationship of cancer and aging.

Journal Article Clin Geriatr Med · August 1987 The major risk factor for cancer is progressive age. Molecular advances in our understanding of carcinogenesis and the aging process are helping to clarify this relationship. The magnitude of cancer in the elderly warrants institution of an active preventi ... Link to item Cite

The effects of aging on phosphofructokinase induction during lymphocyte mitogenesis in relation to DNA and protein synthesis.

Journal Article Mol Cell Biochem · June 1987 The incorporation of radiolabeled leucine into phytohemagglutinin-stimulated human lymphocytes increases by 9 hours after mitogen addition in the young whereas this process is delayed by two-fold in the aged (18 hours). Once induced, the leucine incorporat ... Full text Link to item Cite

Hospital-acquired complications in a randomized controlled clinical trial of a geriatric consultation team.

Journal Article JAMA · May 1, 1987 As part of a controlled clinical trial of a geriatric consultation team (GCT), we investigated whether a GCT could affect the incidence of hospital-acquired complications in elderly patients. One hundred eighty-five patients, aged 75 years and older, were ... Link to item Cite

Clinical utility of erythrocyte sedimentation rate and plasma protein analysis in the elderly.

Journal Article Am J Med · February 1987 The utilization and interpretation of the erythrocyte sedimentation rate in the elderly have been surrounded by controversy and confusion. To improve the understanding of the erythrocyte sedimentation rate and its determinants in the aged, a defined popula ... Full text Link to item Cite

Role of immune stimulation in the etiology of multiple myeloma: a case control study.

Journal Article Am J Hematol · February 1987 A hospital-based case-control study of 153 multiple myeloma (MM) cases and 459 controls was conducted to evaluate the hypothesis that chronic or frequent infections or allergic and autoimmune diseases might be of higher prevalence in individuals who develo ... Full text Link to item Cite

A quantitative analysis of palliative care decisions in acute nonlymphocytic leukemia.

Journal Article J Am Geriatr Soc · February 1987 With the increasing incidence of cancer in elderly patients, decisions to adopt palliative care become particularly relevant to this patient population. In order to define characteristics of decisions to adopt palliative care, including those factors influ ... Full text Link to item Cite

Response by Dr. Cohen

Journal Article Journal of the American Geriatrics Society · January 1, 1987 Full text Cite

Evaluation of monoclonal gammopathies in the "well" elderly.

Journal Article Am J Med · January 1987 The study of monoclonal gammopathies in the elderly provides an opportunity to define immunologic and neoplastic changes with aging. Previous reports using paper and cellulose acetate electrophoresis have documented an age-related increase in monoclonal ga ... Full text Link to item Cite

Malignant melanoma in the elderly.

Journal Article J Clin Oncol · January 1987 Advancing age is associated with poorer prognosis in malignant melanoma. We studied 3,872 cases of malignant melanoma to evaluate whether the effect of age could be analyzed relative to sex, tumor depth, primary site, and other clinical and pathologic vari ... Full text Link to item Cite

Clinical Programs for the Elderly

Journal Article Journal of the American Geriatrics Society · January 1, 1987 Full text Cite

Breast cancer in the elderly. Current patterns of care.

Journal Article J Am Geriatr Soc · September 1986 To evaluate age-related differences in the current patterns of presentation and clinical management of breast cancer patients, the authors reviewed 1795 patients referred to a university hospital for their initial treatment. No age-related differences were ... Full text Link to item Cite

Consolidation and maintenance therapy in multiple myeloma: randomized comparison of a new approach to therapy after initial response to treatment.

Journal Article J Clin Oncol · June 1986 A randomized, controlled trial was initiated in 1977 to evaluate the impact of three alternative approaches to consolidation and maintenance therapy after initial maximal response for multiple myeloma. All patients were treated initially with BCNU, cycloph ... Full text Link to item Cite

Medical problems associated with aging.

Journal Article Clin Obstet Gynecol · June 1986 Full text Link to item Cite

A randomized, controlled clinical trial of a geriatric consultation team. Compliance with recommendations.

Journal Article JAMA · May 16, 1986 As part of a prospective, randomized, controlled study of the effectiveness of a geriatric consultation team, we examined compliance by the house staff with recommendations made by the team. Recommendations were formulated for 185 patients, aged 75 years o ... Link to item Cite

Weekly mitoxantrone therapy for refractory multiple myeloma: a Southeastern Cancer Study Group Trial.

Journal Article Cancer Treat Rep · May 1986 Link to item Cite

Gordon's first law.

Journal Article J Am Geriatr Soc · May 1986 Full text Link to item Cite

Surgical experience of colon resection in the extreme elderly.

Journal Article Am Surg · April 1986 A retrospective review was undertaken at Mount Sinai Medical Center of Miami Beach for patients aged 70 and greater undergoing colon resection between January 1, 1983 and December 31, 1983. These resections were performed for carcinoma 67.3 per cent, diver ... Link to item Cite

Role of protein molecular and metabolic aberrations in aging, in the physiologic decline of the aged, and in age-associated diseases.

Journal Article J Am Geriatr Soc · April 1986 Full text Link to item Cite

Comprehensive care of the elderly patient with cancer.

Journal Article Compr Ther · March 1986 Link to item Cite

Expression of intracellular biochemical defects of lymphocytes in aging: proposal of a general aging mechanism which is not cell-specific.

Journal Article Exp Gerontol · 1986 There is a decline in immune capacity with age which is expressed on the organismic level by association with numerous immune-related diseases, on the cellular level by impaired mitogenesis, on the biochemical level by impaired metabolic pathways, and on t ... Full text Link to item Cite

Multiple myeloma in the elderly

Journal Article Medical Grand Rounds · January 1, 1986 Cite

Multiple myeloma in the elderly.

Journal Article Clin Geriatr Med · November 1985 The incidence of multiple myeloma, a monoclonal gammopathy, increases dramatically with age. The disorder involves a malignant proliferation of plasma cells, which results in abnormal production of immunoglobulin, bone-marrow infiltration, destruction of b ... Link to item Cite

Multiple myeloma and family history of cancer. A case-control study.

Journal Article Cancer · October 15, 1985 A hospital-based case-control study was done to examine the hypothesis that persons with a family history of multiple myeloma (MM) or other cancers are at increased risk of multiple myeloma. Study members were 439 cases of multiple myeloma and 1317 matched ... Full text Link to item Cite

Age and the treatment of multiple myeloma. Southeastern Cancer Study Group experience.

Journal Article Am J Med · September 1985 To determine the impact of age upon the response to treatment, survival, and toxicity of chemotherapy for multiple myeloma, the results of a large cooperative group trial were examined. Patients were randomly assigned to induction therapy with either carmu ... Full text Link to item Cite

The essential role of L-glutamine in lymphocyte differentiation in vitro.

Journal Article J Cell Physiol · August 1985 The biochemistry of human B lymphocyte differentiation to plasma cells is incompletely understood. L-glutamine appears to be required for both lymphoblastic transformation and plasma cell formation in pokeweed-mitogen-stimulated human peripheral blood mono ... Full text Link to item Cite

Evaluation of hyperviscosity in monoclonal gammopathies.

Journal Article Am J Med · July 1985 The serum or plasma hyperviscosity syndrome has been described in both monoclonal and polyclonal immunoglobulin disorders. The usefulness of initial and serial plasma viscosity measurements by an automated viscometer technique was evaluated and compared wi ... Full text Link to item Cite

Carbohydrate metabolism in transforming lymphocytes from the aged.

Journal Article J Cell Physiol · June 1985 There is an age-related decline in immune capacity which has been linked to a decreased response of lymphocytes to mitogens in vitro. During transformation, lymphocytes require a marked increase in energy production and biosynthesis which is supplied prima ... Full text Link to item Cite

Socioeconomic status and risk of multiple myeloma.

Journal Article J Epidemiol Community Health · June 1985 A case control study was conducted to test the hypothesis that socioeconomic status is positively associated with multiple myeloma incidence. One hundred and fifty-three myeloma cases and 459 controls were identified at the Duke University Medical Center a ... Full text Link to item Cite

Decreased protein synthesis of transforming lymphocytes from aged humans: relationship to impaired mitogenesis with age.

Journal Article Mech Ageing Dev · April 1985 Recent studies have indicated that the decline in mitogenesis during the aging process may be related to intracellular defects that become apparent when the cells are subjected to the metabolic stress of cell transformation. We provide the first report of ... Full text Link to item Cite

Culture kinetics of glycolytic enzyme induction, glucose utilization, and thymidine incorporation of extended-exposure phytohemagglutinin-stimulated human lymphocytes.

Journal Article J Cell Physiol · January 1985 Glycolytic enzyme activity is significantly (P less than 0.05) induced between 24 and 48 hours of incubation in phytohemagglutinin-stimulated human lymphocytes. Nonstimulated cultured cells do not show this induction although these cells have an approximat ... Full text Link to item Cite

Host regulation of MOPC 104E plasmacytoma after reduction of tumor burden by total body irradiation.

Journal Article Cancer Invest · 1985 Radiation-sensitive BALB/c MOPC 104E plasmacytoma was studied to investigate the effectiveness of total body irradiation in reducing tumor burden and preventing tumor regrowth. Also noted were the effects of such radiation on host immunity. BALB/c mice bea ... Full text Link to item Cite

The functional approach to the care of the elderly: a conceptual framework.

Journal Article J Am Geriatr Soc · December 1984 A conceptual framework that is based on the biopsychosocial model and focuses on functional status is proposed for the understanding and teaching of the functional approach to health care. Functional status can be viewed as the composition of various biolo ... Full text Link to item Cite

Randomized trial of radiotherapy to the thorax in limited small-cell carcinoma of the lung treated with multiagent chemotherapy and elective brain irradiation: a preliminary report.

Journal Article J Clin Oncol · November 1984 A total of 304 patients with limited small-cell carcinoma of the lung were treated with a combination of cyclophosphamide, Adriamycin (Adria Laboratories, Columbus, Ohio), and vincristine (CAV) and elective brain irradiation (3,600 rad TD in 14 fractions). ... Full text Link to item Cite

Phase II evaluation of chlorozotocin in refractory multiple myeloma.

Journal Article Cancer Treat Rep · November 1984 Link to item Cite

An interdepartmental division of geriatric medicine.

Journal Article J Med Educ · August 1984 Full text Link to item Cite

The effect of age on the accumulation of labile triosephosphate isomerase and thymidine incorporation in pokeweed mitogen stimulated human lymphocytes.

Journal Article J Gerontol · July 1984 Peripheral lymphocytes from young persons were found to increase the content of labile triosephosphate isomerase (TPI) following pokeweed mitogen stimulation in vitro. The labile form appears to have the same thermal inactivation pattern as a tetradeamidat ... Full text Link to item Cite

Werner's syndrome: An underdiagnosed disorder resembling premature aging

Journal Article AGE · July 1, 1984 Werner's syndrome is an inheritable segmental progeroid syndrome manifested by a premature senescent appearance. Juvenile cataract formation and cutaneous atrophy are the most common features of this disease. Differences in geographic prevalence of this di ... Full text Cite

Comparison of two long-term chemotherapy regimens, with or without agents to modify skeletal repair, in multiple myeloma.

Journal Article Blood · March 1984 A randomized controlled trial was initiated in 1972 to compare two chemotherapeutic regimens [1-3-bis (2-chloroethyl) 1-nitrosourea (BCNU), cyclophosphamide, and prednisone versus melphalan and prednisone], to determine whether the two regimens are cross-r ... Link to item Cite

Aging and neoplasia.

Journal Article Annu Rev Gerontol Geriatr · 1984 Link to item Cite

Effects of age on responses to treatment and survival of patients with multiple myeloma.

Journal Article J Am Geriatr Soc · May 1983 The elderly patient with malignancy is often considered a poor risk for treatment. To assess the effect of age on the treatment of one such disease, multiple myeloma (a disease with increased incidence in the elderly), a study was made of 280 patients trea ... Full text Link to item Cite

Aberrant interaction of B-cell lymphocytic leukemia cells with antibody coated polyacrylamide beads.

Journal Article Exp Hematol · February 1983 Anti-immunoglobulin coated polyacrylamide beads have been used to assess surface membrane immunoglobulin in normal and lymphoproliferative states. The polyvalent anti-immunoglobulin bead reacts with normal B cells and cells from patients with hairy cell le ... Link to item Cite

An approach to monoclonal gammopathies in the elderly.

Journal Article Geriatrics · October 1982 Link to item Cite

Cisplatin, BCNU, cyclophosphamide, and prednisone in multiple myeloma.

Journal Article Cancer Treat Rep · February 1982 Using the MOPC 104E murine plasmacytoma model, Ghanta et al have shown major synergism when cisplatin was added to a treatment program with BCNU and cyclophosphamide (CTX). To evaluate possible synergism in the treatment of human multiple myeloma (MM), 23 ... Link to item Cite

Hexamethylmelamine and prednisone in the treatment of refractory multiple myeloma.

Journal Article Am J Clin Oncol · February 1982 Hexamethylmelamine (280 mg/m2) daily for 21 days every 28 days was given, with prednisone 75 mg on days 1-7, to patients with multiple myeloma failing to respond to, or relapsing from, previous therapy. All patients had received the same dose of prednisone ... Link to item Cite

Prednisone-responsive aplastic anemia associated with T-lymphocyte proliferation.

Journal Article Am J Hematol · November 1981 In some cases, bone marrow aplasia has been thought to result from immunologic abnormalities. Our patient had severe transfusion-dependent aplastic anemia, which responded to treatment with prednisone on two occasions. The exacerbations of aplastic anemia ... Full text Link to item Cite

Assessment of myeloma maintenance regimen of prednisone. Adriamycin, imuran, and vincristine in a murine plasmacytoma model.

Journal Article Cancer Clin Trials · 1981 A current southeastern cancer study group protocol for the treatment of multiple myeloma involves induction with BCNU, cyclophosphamide, and prednisone (BCP) and maintenance with either melphalan and prednisone (MP), prednisone, Adriamycin, imuran, and vin ... Link to item Cite

Alternative approaches to therapy after plateau in multiple myeloma

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1981 Cite

Therapy of myeloma.

Journal Article Blood · June 1980 Link to item Cite

Beta adrenergic receptors in lymphocyte subpopulations.

Journal Article J Allergy Clin Immunol · January 1980 To further evaluate the potential utility of lymphocyte beta adrenergic receptor assays in the study of receptor alterations in human disease, we studied highly purified populations of B and T lymphocytes in peripheral blood to see if differences existed i ... Full text Link to item Cite

Combination chemotherapy with intermittent 1-3-bis(2-chloroethyl)1-nitrosourea (BCNU), cyclophosphamide, and prednisone for multiple myeloma.

Journal Article Blood · October 1979 Link to item Cite

Renal-failure anemia and nitrosourea therapy.

Journal Article N Engl J Med · September 20, 1979 Full text Link to item Cite

Pseudo-Gaucher cells in multiple myeloma.

Journal Article Am J Med · August 1979 A bone biopsy specimen from a patient with multiple myeloma showed numerous Gaucher-like cells scattered throughout a homogeneous background of plasma cells. Further studies using histochemical stains, immunofluorescence, and light and electron microscopy ... Full text Link to item Cite

Arsenic-induced bone marrow toxicity: ultrastructural and electron-probe analysis.

Journal Article Blood · May 1979 A patient with severe arsenic poisoning that resulted in marked peripheral blood and bone marrow abnormalities, including megaloblastic erythropoiesis experienced many of the previously reported hematologic complications of arsenic poisoning: leukopenia, g ... Link to item Cite

Hairy cell leukemia: cellular characteristics including surface immunoglobulin dynamics and biosynthesis.

Journal Article Blood · April 1979 Link to item Cite

Hairy cell leukemia-associated familial lymphoproliferative disorder: immunologic abnormalities in unaffected family members.

Journal Article Ann Intern Med · February 1979 Three generations of a family were affected by hematologic malignancies: the proband had hairy cell leukemia, his brother chronic lymphocytic leukemia, his nephew cutaneous and central nervous system lymphoma, and his father chronic granulocytic leukemia. ... Full text Link to item Cite

Kinetics of immunoglobulin synthesis and secretion by resting and pokeweed mitogen-transformed human lymphocytes.

Journal Article Clin Immunol Immunopathol · January 1979 Full text Link to item Cite

The kinetics of immunoglobulin synthesis by pokeweed mitogen stimulated peripheral blood lymphocytes in multiple myeloma.

Journal Article Am J Hematol · 1979 As a means of investigating the immunoglobulin (Ig) deficiency in multiple myeloma, the effects of pokeweed mitogen (PWM) on morphologic transformation and concomitant immunoglobulin synthesis and secretion kinetics were studied in peripheral blood lymphoc ... Full text Link to item Cite

Myelomatous pleural effusion: clinical course and immunologic characterization of the pleural fluid cells.

Journal Article Am J Hematol · 1979 Multiple myeloma is a disease that infrequently involves nonreticuloendothelial tissues and rarely causes pleural effusion. A 59-year-old woman had pleural effusion as the major manifestation of multiple myeloma. Light microscopy of her pleural fluid with ... Full text Link to item Cite

Unmaintained remission after two years of combination chemotherapy in myeloma

Journal Article Proceedings of the American Association for Cancer Research · 1979 Cite

Unmaintained remission after two years of combination chemotherapy in myeloma

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1979 Cite

Combination chemotherapy for primary amyloidosis reconsidered.

Journal Article Ann Intern Med · October 1978 Full text Link to item Cite

B-cell lymphosarcoma cell leukemia: dynamics of surface-membrance immunoglobulin. Value for differentiation from chronic lymphocytic leukemia.

Journal Article Ann Intern Med · March 1978 Circulating abnormal lymphoid cells in patients with lymphosarcoma cell leukemia show intense fluorescence when stained with fluoroscein-labeled anti-immunoglobulin. The fluorescence is brighter than normal B cells in contrast with chronic lymphocytic leuk ... Full text Link to item Cite

New presentation of alpha heavy chain disease: North American polypoid gastrointestinal lymphoma. Clinical and cellular studies.

Journal Article Cancer · March 1978 Alpha Heavy Chain Disease has generally been described in the Mediterranean area in young people with a diffuse gastrointestinal lymphoma and malabsorption. We describe a patient from the United States with polypoid lymphoma of the gastrointestinal tract a ... Full text Link to item Cite

Transient monoclonal immunoglobulin G with anti-dextran activity.

Journal Article Acta Haematol · 1978 A patient with regional enteritis had received iron dextran for treatment of iron deficiency. Subsequently he developed a large (3.1 g/100 ml) IgG-K serum spike which had precipitin activity against dextran sulfate but not a variety of other antigens. Ther ... Full text Link to item Cite

Replication of type I herpes simplex virus in primary cultures of hairy cell leukemic leukocytes.

Journal Article Am J Pathol · January 1978 The ability of leukemic leukocytes to support the replication of herpes simplex virus (HSV) was studied. Mononuclear leukocytes (MNL) from the peripheral blood of patients with a variety of lymphoid leukemias were isolated on Ficoll-Hypaque gradients and i ... Link to item Cite

Corticosteroid-induced lymphocytopenia in man: absence of splenic influence and effect of recipient serum.

Journal Article Am J Hematol · 1978 Pharmacologic doses of corticosteroids produce a profound, transient lymphocytopenia in man. We have studied the role of the spleen and possible induction of cytolytic factors in the generation of this effect. A 200 mg IV dose of hydrocortisone-21-hemisucc ... Full text Link to item Cite

In vitro kinetics of immunoglobulin synthesis and secretion by nonsecretory human myeloma cells.

Journal Article Blood · December 1977 Link to item Cite

Human lymphocyte complement receptors. Quantitative requirements for C3 of normal and chronic lymphocyte leukemia lymphocytes.

Journal Article J Clin Invest · November 1977 Erythrocytes coated with varying amounts of human complement were used to detect lymphocytes with complement receptors from normal subjects and patients with chronic lymphocytic leukemia. The relationship between the percentage of lymphocytes rosetting and ... Full text Link to item Cite

Long term evaluation of prognostic factors in BCNU, cyclophosphamide, prednisone (BCP) treatment of myeloma

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1977 Cite

Human lymphocyte motility: normal characteristics and anomalous behavior of chronic lymphocytic leukemia cells.

Journal Article Blood · November 1976 The characteristics of human lymphocyte motility and its relationship to the redistribution of surface membrane antigens (capping) are poorly defined. Since chronic lymphocytic leukemia (CLL) cells cap poorly when compared with normal human lymphocytes, th ... Link to item Cite

BCNU, cyclophosphamide, and prednisone (BCP) vs. melphalan and prednisone (MP) in myeloma

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1976 Cite

Combination chemotherapy with vincristine, cyclophosphamide, and prednisone producing long-term remission of a transplanted canine lymphoma.

Journal Article Am J Vet Res · October 1975 Lymphoma developed in 6 neonatal pups inoculated with 1.0 to 2.06 X 10(9) cells of the 2nd in vivo passage of a canine lymphoma. Three to 4 weeks later (or 8 weeks after the pups had been inoculated), 3 of the 6 pups were started on a chemotherapeutic regi ... Link to item Cite

Resolution of primary amyloidosis during chemotherapy. Studies in a patient with nephrotic syndrome.

Journal Article Ann Intern Med · April 1975 A patient with primary amyloidosis with evidence for a plasma cell dyscrasia but no abnormal immunoglobulin components had nephrotic syndrome with severe renal impairment. Kidney and bone marrow had extensive amyloid infiltration. She was treated with peni ... Full text Link to item Cite

Meningeal mycosis fungoides: clinical and cellular characteristics.

Journal Article Ann Intern Med · April 1975 A patient with mycosis fungoides developed meningeal disease while his skin disease was in remission with systemic chemotherapy. His central nervous system involvement with mycosis fungoides was controlled with intrathecal methotrexate for 7 months. The pr ... Full text Link to item Cite

Intranuclear inclusions in Bence Jones lambda plasma cell myeloma.

Journal Article Blood · January 1975 A patient with plasma cell myeloma producing only Bence Jones lambda protein was found to have pale intranuclear inclusions in the majority of the bone marrow plasma cells. These inclusions, previously undescribed in myeloma patients producing only Bence J ... Link to item Cite

Managing the complications of plasma cell myeloma.

Journal Article Arch Intern Med · January 1975 Management of some diverse complications of plasma cell myeloma is reviewed with respect to prevention when possible and prompt treatment when necessary. A series of 102 patients from the Duke University Medical Center was surveyed to ascertain the approxi ... Link to item Cite

Human lymphocyte surface immunoglobulin capping. Normal characteristics and anomalous behavior of chronic lymphocytic leukemic lymphocytes.

Journal Article J Clin Invest · January 1975 The phenomenon of redistribution of surface membrane immunoglobulin (Ig) components (capping) has been well described in mouse lymphoid cells. The characteristics of this process in human lymphocytes are less clear. This study characterizes the phenomenon ... Full text Link to item Cite

The synthesis and secretion of gamma-globulin by lymph node cells. V. The dissociation of the microsome-antibody complex with enzymatically and chemically altered gamma-globulins.

Journal Article J Biol Chem · January 25, 1969 Link to item Cite

Synthesis and secretion of gamma-globulin by lymph node cells. VI. Characteristics of the structure of immunoglobulin A and its pattern of secretion by appendix cell suspensions.

Journal Article Biochim Biophys Acta · 1969 Full text Link to item Cite

Cytologic studies of glucose-6-phosphate dehydrogenase in malignancy.

Journal Article Cancer · June 1968 Full text Link to item Cite