Scholars@Duke
Scott Haden Kollins

Scott Haden Kollins

Adjunct Professor in the Department of Psychiatry and Behavioral Sciences
Psychiatry, Child & Family Mental Health & Community Psychiatry
kolli001@mc.duke.edu
Box 3527 Med Ctr, Durham, NC 27710
2608 Erwin Road Lakeview Pavi, Durham, NC 27705

Selected Publications

A digital intervention for cognitive deficits following COVID-19: a randomized clinical trial.

Journal Article Neuropsychopharmacology · October 2, 2024 Post-COVID-19 cognitive deficits are common, persistent, and disabling. Evidence on effective treatments is limited. The goal of this study was to investigate the efficacy of a digital intervention to reduce cognitive and functional deficits in adults with ... Full text Link to item Cite

Real world analysis of treatment change and response in adults with attention-deficit/hyperactivity disorder (ADHD) alone and with concomitant psychiatric comorbidities: results from an electronic health record database study is the United States.

Journal Article BMC Psychiatry · September 16, 2024 BACKGROUND: The objectives of this study were to examine the association of psychiatric comorbidities and patient characteristics with treatment change and response as well as to assess the association between treatment change and healthcare resource utili ... Full text Link to item Cite

Behavioral characteristics of toddlers later identified with an autism diagnosis, ADHD symptoms, or combined autism and ADHD symptoms.

Journal Article J Child Psychol Psychiatry · September 3, 2024 BACKGROUND: Autism commonly co-occurs with attention-deficit/hyperactivity disorder (ADHD), but less is known regarding how ADHD symptoms impact the early presentation of autism. This study examined early behavioral characteristics of a community sample of ... Full text Link to item Cite

Adaptive Behavior in Young Autistic Children: Associations with Irritability and ADHD Symptoms.

Journal Article J Autism Dev Disord · September 2024 Attention-deficit/hyperactivity disorder (ADHD) symptoms affect 40-60% of autistic children and have been linked to differences in adaptive behavior. It is unclear whether adaptive behavior in autistic youth is directly impacted by co-occurring ADHD sympto ... Full text Link to item Cite

Real-time cognitive performance metrics derived from a digital therapeutic for inattention predict ADHD-related clinical outcomes: Replication across three independent trials of AKL-T01.

Journal Article Transl Psychiatry · August 11, 2024 AKL-T01 is a digital therapeutic (DTx) that targets attention by generating conflict at dynamically updated difficulty levels during a multitasking game. Clinical trials support AKL-T01's efficacy in attention-deficit/hyperactivity disorder (ADHD), but the ... Full text Link to item Cite

Brief Report: Relationships Between Caregiver-Reported Externalizing and Internalizing Behaviors and the Modified Checklist for Autism in Toddlers.

Journal Article J Autism Dev Disord · July 12, 2024 PURPOSE: Early detection and intervention are associated with improved outcomes for autistic children. Thus, it is important to understand factors influencing early screening tools designed to detect autism. This study examined the relationship between car ... Full text Link to item Cite

Secondary analyses of sex differences in attention improvements across three clinical trials of a digital therapeutic in children, adolescents, and adults with ADHD.

Journal Article BMC Public Health · April 29, 2024 BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) remains underdiagnosed and undertreated in girls. Inattentive symptoms, often predominant in girls with ADHD, represent a key driver of impairment and often persist into adulthood. AKL-T01 is a re ... Full text Link to item Cite

Sleep Physiology and Neurocognition Among Adolescents With Attention-Deficit/Hyperactivity Disorder.

Journal Article J Am Acad Child Adolesc Psychiatry · March 12, 2024 OBJECTIVE: Few studies have characterized the nature of sleep problems among adolescents with attention-deficit/hyperactivity disorder (ADHD) using polysomnography (PSG). Additionally, although adolescents with ADHD and adolescents with sleep disturbances ... Full text Link to item Cite

Serdexmethylphenidate/dexmethylphenidate for children with attention-deficit/hyperactivity disorder: dose optimization from a laboratory classroom study.

Journal Article Front Psychiatry · 2024 OBJECTIVE: To evaluate treatment responder rate using the Attention-Deficit/Hyperactivity Disorder Rating Scale-5 (ADHD-RS-5) score based on optimized dose level of serdexmethylphenidate/dexmethylphenidate (SDX/d-MPH) and changes in ADHD severity in childr ... Full text Link to item Cite

Serdexmethylphenidate/dexmethylphenidate capsules for children and adolescents with attention-deficit/hyperactivity disorder (ADHD): a plain language summary

Journal Article Future Neurology · January 1, 2024 What is this summary about?: This is a plain language summary of 2 articles published in the Journal of Child and Adolescent Psychopharmacology. It describes a medication called serdexmethylphenidate/dexmethylphenidate, or SDX/d-MPH for short. SDX/d-MPH is ... Full text Cite

Associations of comorbid substance use disorders with clinical outcomes in schizophrenia using electronic health record data.

Journal Article Schizophr Res · October 2023 BACKGROUND AND HYPOTHESIS: Schizophrenia and comorbid substance use disorders (SUDs) are associated with poor treatment outcomes but differences between the associations of different SUDs with clinical outcomes are poorly characterized. This study examines ... Full text Link to item Cite

"Click and mortar" opportunities for digitization and consumerism in trials.

Journal Article Contemp Clin Trials · September 2023 BACKGROUND: Digitization (using novel digital tools and strategies) and consumerism (taking a consumer-oriented approach) are increasingly commonplace in clinical trials, but the implications of these changes are not well described. METHODS: We assembled a ... Full text Link to item Cite

Prenatal and Childhood Smoke Exposure Associations with Cognition, Language, and Attention-Deficit/Hyperactivity Disorder.

Journal Article J Pediatr · May 2023 OBJECTIVE: To assess the relationships of prenatal and childhood smoke exposure with specific neurodevelopmental and behavioral problems during early childhood. STUDY DESIGN: A subsample (n = 386) of mother-child dyads from the Newborn Epigenetic Study (NE ... Full text Link to item Cite

Early trajectory of clinical global impression as a transdiagnostic predictor of psychiatric hospitalisation: a retrospective cohort study.

Journal Article Lancet Psychiatry · May 2023 BACKGROUND: Identifying patients most at risk of psychiatric hospitalisation is crucial to improving service provision and patient outcomes. Existing predictors focus on specific clinical scenarios and are not validated with real-world data, limiting their ... Full text Link to item Cite

Predictive Value of Early Autism Detection Models Based on Electronic Health Record Data Collected Before Age 1 Year.

Journal Article JAMA Netw Open · February 1, 2023 IMPORTANCE: Autism detection early in childhood is critical to ensure that autistic children and their families have access to early behavioral support. Early correlates of autism documented in electronic health records (EHRs) during routine care could all ... Full text Link to item Cite

Intranasal Use of Prescription Stimulants Among Adults Aged 18 to 30: Results From A Crowdsourcing Platform.

Journal Article J Atten Disord · January 2023 OBJECTIVE: Few studies of prescription stimulant non-oral, non-medical use (NMU) (defined by use not as prescribed) have been conducted in adults beyond the college population. The purpose of this study was to characterize prescription stimulant non-oral u ... Full text Link to item Cite

Screen media technology and ADHD in children and adolescents: Potential perils and emerging opportunities

Chapter · January 1, 2023 Screen media technology (SMT) use has become increasingly prevalent among youth, and is associated with a variety of negative outcomes, including poor sleep and impairments in several domains of cognitive functioning, including task-switching, attention, w ... Full text Cite

Sleep onset, duration, or regularity: which matters most for child adiposity outcomes?

Conference Int J Obes (Lond) · August 2022 BACKGROUND/OBJECTIVES: Sleep measures, such as duration and onset timing, are associated with adiposity outcomes among children. Recent research among adults has considered variability in sleep and wake onset times, with the Sleep Regularity Index (SRI) as ... Full text Link to item Cite

Regularity and Timing of Sleep Patterns and Behavioral Health Among Adolescents.

Journal Article J Dev Behav Pediatr · May 1, 2022 OBJECTIVE: Sleep is vital to supporting adolescent behavioral health and functioning; however, sleep disturbances remain under-recognized and undertreated in many health care settings. One barrier is the complexity of sleep, which makes it difficult for pr ... Full text Link to item Cite

NeuroBlu, an electronic health record (EHR) trusted research environment (TRE) to support mental healthcare analytics with real-world data.

Journal Article BMJ Open · April 22, 2022 PURPOSE: NeuroBlu is a real-world data (RWD) repository that contains deidentified electronic health record (EHR) data from US mental healthcare providers operating the MindLinc EHR system. NeuroBlu enables users to perform statistical analysis through a s ... Full text Link to item Cite

Parenting Stress, Child Weight-Related Behaviors, and Child Weight Status.

Journal Article Child Obes · April 2022 Background: There has been limited examination of the association between parenting stress and child weight-related behaviors. We aimed to determine whether parenting stress is associated with child weight-related behaviors, including physical activity, sc ... Full text Link to item Cite

Shuffle the Decks: Children Are Sensitive to Incidental Nonrandom Structure in a Sequential-Choice Task.

Journal Article Psychol Sci · April 2022 As children age, they can learn increasingly complex features of environmental structure-a key prerequisite for adaptive decision-making. Yet when we tested children (N = 304, 4-13 years old) in the Children's Gambling Task, an age-appropriate variant of t ... Full text Link to item Cite

Impact of daily caffeine intake and timing on electroencephalogram-measured sleep in adolescents.

Journal Article J Clin Sleep Med · March 1, 2022 STUDY OBJECTIVES: Caffeine use is ubiquitous among adolescents and may be harmful to sleep, with downstream implications for health and development. Research has been limited by self-reported and/or aggregated measures of sleep and caffeine collected at a ... Full text Link to item Cite

ADHD, Religiosity, and Psychiatric Comorbidity in Adolescence and Adulthood.

Journal Article J Atten Disord · January 2022 OBJECTIVE: Religiosity has been repeatedly proposed as protective in the development of depression, sociopathy and addictions. ADHD frequently co-occurs with these same conditions. Although ADHD symptoms may affect religious practice, religiosity in ADHD r ... Full text Link to item Cite

Pragmatic adaptations of telehealth-delivered caregiver coaching for children with autism in the context of COVID-19: Perspectives from the United States and South Africa.

Journal Article Autism · January 2022 COVID-19 caused many autism spectrum disorder caregiver-coaching studies to move to telehealth. Telehealth can increase the diversity of people who take part in research. This matters because most autism spectrum disorder studies have included people who h ... Full text Link to item Cite

Eveningness Diurnal Preference: Putting the "Sluggish" in Sluggish Cognitive Tempo.

Journal Article J Atten Disord · December 2021 OBJECTIVE: Eveningness diurnal preference is common in psychiatric conditions, including attention-deficit/hyperactivity disorder (ADHD) and internalizing disorders. Little is known about how diurnal preference relates to sluggish cognitive tempo (SCT)-a d ... Full text Link to item Cite

Large-scale genetic investigation reveals genetic liability to multiple complex traits influencing a higher risk of ADHD.

Journal Article Sci Rep · November 19, 2021 Attention Deficit-Hyperactivity Disorder (ADHD) is a complex psychiatric and neurodevelopmental disorder that develops during childhood and spans into adulthood. ADHD's aetiology is complex, and evidence about its cause and risk factors is limited. We leve ... Full text Link to item Cite

Efficacy and Safety of a Long-Acting Multilayer-Release Methylphenidate Formulation (PRC-063) in the Treatment of Adolescent Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind Clinical Trial with a 6-Month Open-Label Extension.

Journal Article J Child Adolesc Psychopharmacol · November 2021 Objectives: To study the safety and efficacy of the long-acting methylphenidate formulation PRC-063 in adolescents with attention-deficit/hyperactivity disorder (ADHD). Methods: Adolescents 12 to ≤17 years who met Diagnostic and Statistical Manual of Menta ... Full text Link to item Cite

A Randomized, Controlled Laboratory Classroom Study of Serdexmethylphenidate and d-Methylphenidate Capsules in Children with Attention-Deficit/Hyperactivity Disorder.

Journal Article J Child Adolesc Psychopharmacol · November 2021 Objectives: To evaluate the efficacy and safety of once-daily serdexmethylphenidate/dexmethylphenidate (SDX/d-MPH) capsules (Azstarysâ„¢) compared with placebo in children with attention-deficit/hyperactivity disorder (ADHD) in a randomized, double-blind, do ... Full text Link to item Cite

Patterns of Health Services Use Before Age 1 in Children Later Diagnosed With ADHD.

Journal Article J Atten Disord · October 2021 Background: Children with ADHD have 2 to 3 times increased health care utilization and annual costs once diagnosed, but little is known about utilization patterns early in life, prior to diagnosis. Quantifying early health services use among children later ... Full text Link to item Cite

The World Federation of ADHD International Consensus Statement: 208 Evidence-based conclusions about the disorder.

Journal Article Neurosci Biobehav Rev · September 2021 BACKGROUND: Misconceptions about ADHD stigmatize affected people, reduce credibility of providers, and prevent/delay treatment. To challenge misconceptions, we curated findings with strong evidence base. METHODS: We reviewed studies with more than 2000 par ... Full text Link to item Cite

A scalable computational approach to assessing response to name in toddlers with autism.

Journal Article J Child Psychol Psychiatry · September 2021 BACKGROUND: This study is part of a larger research program focused on developing objective, scalable tools for digital behavioral phenotyping. We evaluated whether a digital app delivered on a smartphone or tablet using computer vision analysis (CVA) can ... Full text Link to item Cite

Reactions to reduced nicotine content cigarettes in a sample of young adult, low-frequency smokers.

Journal Article Psychopharmacology (Berl) · September 2021 RATIONALE: Reducing nicotine content in cigarettes to ≤ 2.4 mg per g of tobacco [mg/g] reduces smoking behavior and toxicant exposure among adult daily smokers. However, cigarettes with similar nicotine content could support continued experimentation and s ... Full text Link to item Cite

The role of machine learning in clinical research: transforming the future of evidence generation.

Journal Article Trials · August 16, 2021 BACKGROUND: Interest in the application of machine learning (ML) to the design, conduct, and analysis of clinical trials has grown, but the evidence base for such applications has not been surveyed. This manuscript reviews the proceedings of a multi-stakeh ... Full text Open Access Link to item Cite

Computational Methods to Measure Patterns of Gaze in Toddlers With Autism Spectrum Disorder.

Journal Article JAMA Pediatr · August 1, 2021 IMPORTANCE: Atypical eye gaze is an early-emerging symptom of autism spectrum disorder (ASD) and holds promise for autism screening. Current eye-tracking methods are expensive and require special equipment and calibration. There is a need for scalable, fea ... Full text Link to item Cite

Associations between maternal obesity, gestational cytokine levels and child obesity in the NEST cohort.

Journal Article Pediatr Obes · July 2021 BACKGROUND: Although maternal systemic inflammation is hypothesized to link maternal pre-pregnancy obesity to offspring metabolic dysfunction, patient empirical data are limited. OBJECTIVES: In this study, we hypothesized that pre-pregnancy obesity alters ... Full text Link to item Cite

Identifying the Best Questions for Rapid Screening of Secondhand Smoke Exposure Among Children.

Journal Article Nicotine Tob Res · June 8, 2021 INTRODUCTION: Many children suffer from secondhand smoke exposure (SHSe), which leads to a variety of negative health consequences. However, there is no consensus on how clinicians can best query parents for possible SHSe among children. We employed a data ... Full text Link to item Cite

Open-Label Dose Optimization of Methylphenidate Extended-Release Orally Disintegrating Tablet in a Laboratory Classroom Study of Children with Attention-Deficit/Hyperactivity Disorder.

Journal Article J Child Adolesc Psychopharmacol · June 2021 Objective: To examine the efficacy, safety, and tolerability of methylphenidate extended-release orally disintegrating tablets (MPH XR-ODT) for the treatment of attention-deficit/hyperactivity disorder (ADHD) during the open-label dose-optimization/stabili ... Full text Link to item Cite

Smoke-Free Home Rules and Association with Child Secondhand Smoke Exposure among Mother-Child Dyad Relationships.

Journal Article Int J Environ Res Public Health · May 14, 2021 Smoke-free home rules restrict smoking in the home, but biomarkers of secondhand smoke exposure are needed to help understand the association between smoke-free homes and child secondhand smoke exposure. Participants (n = 346) were majority Black/African A ... Full text Link to item Cite

DNA Methylation in Babies Born to Nonsmoking Mothers Exposed to Secondhand Smoke during Pregnancy: An Epigenome-Wide Association Study.

Journal Article Environ Health Perspect · May 2021 BACKGROUND: Maternal smoking during pregnancy is related to altered DNA methylation in infant umbilical cord blood. The extent to which low levels of smoke exposure among nonsmoking pregnant women relates to offspring DNA methylation is unknown. OBJECTIVE: ... Full text Open Access Link to item Cite

Pharmacotherapy for Preschool Children with Attention Deficit Hyperactivity Disorder (ADHD): Current Status and Future Directions.

Journal Article CNS Drugs · April 2021 In this review, we consider issues relating to the pharmacological treatment of young children with attention deficit hyperactivity disorder (ADHD). ADHD in preschool-age children has a profound impact on psychosocial function and developmental trajectory. ... Full text Link to item Cite

Effectiveness of a digital therapeutic as adjunct to treatment with medication in pediatric ADHD.

Journal Article NPJ Digit Med · March 26, 2021 STARS-Adjunct was a multicenter, open-label effectiveness study of AKL-T01, an app and video-game-based treatment for inattention, as an adjunct to pharmacotherapy in 8-14-year-old children with attention-deficit/hyperactivity disorder (ADHD) on stimulant ... Full text Link to item Cite

Sluggish Cognitive Tempo in Adults Referred for an ADHD Evaluation: A Psychometric Analysis of Self- and Collateral Report.

Journal Article J Atten Disord · February 2021 Objective: Sluggish cognitive tempo (SCT) symptoms uniquely contribute to psychiatric and functional outcomes in child samples; however, the psychometric properties of SCT measures among adult outpatients are unknown. Method: Adults (n = 124) presenting fo ... Full text Link to item Cite

Attention-deficit/hyperactivity disorder and the explore/exploit trade-off.

Journal Article Neuropsychopharmacology · February 2021 The ability to maximize rewards and minimize the costs of obtaining them is vital to making advantageous explore/exploit decisions. Exploratory decisions are theorized to be greater among individuals with attention-deficit/hyperactivity disorder (ADHD), po ... Full text Link to item Cite

Editorial: Is child mental health research structurally racist?

Journal Article J Child Psychol Psychiatry · February 2021 The past year has accelerated global discourse on the role played by institutional and societal factors in perpetuating inequities between racial and ethnic groups across all aspects of life. This editorial considers whether our traditional approaches to c ... Full text Link to item Cite

It Is Time to REACT: Opportunities for Digital Mental Health Apps to Reduce Mental Health Disparities in Racially and Ethnically Minoritized Groups.

Journal Article JMIR Ment Health · January 26, 2021 The behavioral health toll of the COVID-19 pandemic and systemic racism has directed increased attention to the potential of digital health as a way of improving access to and quality of behavioral health care. However, as the pandemic continues to widen h ... Full text Link to item Cite

Refraining from use diminishes cannabis-associated epigenetic changes in human sperm.

Journal Article Environ Epigenet · 2021 Cannabis use alters sperm DNA methylation, but the potential reversibility of these changes is unknown. Semen samples from cannabis users and non-user controls were collected at baseline and again following a 77-day period of cannabis abstinence (one sperm ... Full text Open Access Link to item Cite

Attention-deficit/hyperactivity disorder and college students

Chapter · December 4, 2020 ADHD is a neurodevelopmental disorder characterized by inattention, hyperactivity, and/or impulsivity that can cause impairment in a variety of domains across the life span. This chapter reviews the history and prevalence of ADHD as well as known etiologic ... Full text Cite

Sluggish cognitive tempo (SCT) in an adult outpatient sample seeking an attention-deficit/hyperactivity disorder assessment: Age of onset and assessment method impact on SCT rates.

Journal Article J Psychiatr Res · December 2020 BACKGROUND: Sluggish cognitive tempo (SCT) is associated with-but distinct from-attention-deficit/hyperactivity disorder (ADHD). This study examined SCT rates in adult outpatients seeking an ADHD assessment, differences in rates based on ADHD status, impac ... Full text Link to item Cite

It Is Time to REACT: Opportunities for Digital Mental Health Apps to Reduce Mental Health Disparities in Racially and Ethnically Minoritized Groups (Preprint)

Journal Article · November 2, 2020 UNSTRUCTUREDThe behavioral health toll of the COVID-19 pandemic and systemic racism has directed increased attention to the potential of digital health as a way of improving access to and ... Full text Cite

Health system utilization before age 1 among children later diagnosed with autism or ADHD.

Journal Article Sci Rep · October 19, 2020 Children with autism spectrum disorder (ASD) or attention deficit hyperactivity disorder (ADHD) have 2-3 times increased healthcare utilization and annual costs once diagnosed, but little is known about their utilization patterns early in life. Quantifying ... Full text Link to item Cite

A Pharmacokinetic Study of Methylphenidate Hydrochloride Multilayer Extended-Release Capsules (Aptensio XR®) in Preschool-Aged Children with Attention-Deficit/Hyperactivity Disorder.

Journal Article Paediatr Drugs · October 2020 OBJECTIVE: This was a single-dose, one-period, multicenter, pharmacokinetic (PK) study to evaluate the PK of methylphenidate (MPH) hydrochloride multilayer extended-release capsules (MPH-MLR) in preschool children aged 4 to < 6 years, previously diagnosed ... Full text Link to item Cite

Feasibility and Acceptability of Wearable Sleep Electroencephalogram Device Use in Adolescents: Observational Study.

Journal Article JMIR Mhealth Uhealth · October 1, 2020 BACKGROUND: Adolescence is an important life stage for the development of healthy behaviors, which have a long-lasting impact on health across the lifespan. Sleep undergoes significant changes during adolescence and is linked to physical and psychiatric he ... Full text Link to item Cite

5.13 EXPLORING ENGAGEMENT AS A FACTOR FOR EFFICACY WITH AKL-T01, A HOME-BASED DIGITAL THERAPEUTIC

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2020 Full text Cite

Data from: Cannabinoid exposure and altered DNA methylation in rat and human sperm

Dataset · August 25, 2020 This dataset contains the raw sequencing data files for reduced representation bisulfite sequencing. Abstract: Little is known about the reproductive effects of paternal cannabis exposure. We evaluated associations between cannabis or tetrahydrocannabinol ... Full text Cite

Associations between attention deficit hyperactivity disorder symptoms and eating behaviors in early childhood.

Journal Article Pediatr Obes · July 2020 BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) symptoms have been linked with eating behaviors and obesity adolescence and young adulthood. Yet, little is known about whether these associations occur during early childhood and few studies have ... Full text Link to item Cite

Feasibility and Acceptability of Wearable Sleep Electroencephalogram Device Use in Adolescents: Observational Study (Preprint)

Journal Article · May 25, 2020 BACKGROUNDAdolescence is an important life stage for the development of healthy behaviors, which have a long-lasting impact on health across the lifespan. Sleep undergoes significant chan ... Full text Cite

Increased subjective and reinforcing effects of initial nicotine exposure in young adults with attention deficit hyperactivity disorder (ADHD) compared to matched peers: results from an experimental model of first-time tobacco use.

Journal Article Neuropsychopharmacology · April 2020 Individuals with attention deficit hyperactivity disorder (ADHD) are at increased risk for adverse cigarette smoking outcomes, and little is known about factors underlying this risk. This study sought to evaluate the effects of initial nicotine exposure in ... Full text Link to item Cite

Lisdexamfetamine Dimesylate for Preschool Children with Attention-Deficit/Hyperactivity Disorder.

Journal Article J Child Adolesc Psychopharmacol · April 2020 Objectives: Describe the safety and tolerability of lisdexamfetamine dimesylate (LDX) and provide data on clinical effects for efficacy-related endpoints and pharmacokinetics in preschool-aged children with attention-deficit/hyperactivity disorder (ADHD). ... Full text Link to item Cite

A novel digital intervention for actively reducing severity of paediatric ADHD (STARS-ADHD): a randomised controlled trial.

Journal Article Lancet Digit Health · April 2020 BACKGROUND: Attention-deficit hyperactivity disorder (ADHD) is a common paediatric neurodevelopmental disorder with substantial effect on families and society. Alternatives to traditional care, including novel digital therapeutics, have shown promise to re ... Full text Link to item Cite

Randomized, Double-Blind, Placebo-Controlled, Flexible-Dose Titration Study of Methylphenidate Hydrochloride Extended-Release Capsules (Aptensio XR) in Preschool Children with Attention-Deficit/Hyperactivity Disorder.

Journal Article J Child Adolesc Psychopharmacol · March 2020 Objectives: To assess the efficacy and safety of a methylphenidate hydrochloride extended-release capsule (MPH-MLR) formulation in treating attention-deficit/hyperactivity disorder (ADHD) in preschool children. Methods: Children aged 4 to <6 years with qua ... Full text Link to item Cite

Author Correction: Validation of the Sleep Regularity Index in Older Adults and Associations with Cardiometabolic Risk.

Journal Article Sci Rep · February 14, 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Full text Link to item Cite

Editorial: From risk prediction to action: leveraging electronic health records to improve pediatric population mental health.

Journal Article J Child Psychol Psychiatry · February 2020 The identification of child, family, and other environmental factors that confer risk for poor developmental outcomes has long been a major theme in child and adolescent psychopathology research. Over the past 6 decades, the Journal of Child Psychology & P ... Full text Link to item Cite

Effect of Prenatal Smoke Exposure on Birth Weight: The Moderating Role of Maternal Depressive Symptoms.

Journal Article Nicotine Tob Res · January 27, 2020 INTRODUCTION: Both prenatal smoke exposure and depression have been linked to lower birth weight, a risk factor for morbidity and mortality. Few studies have looked at the interaction between these risk factors and none have used a biomarker to objectively ... Full text Open Access Link to item Cite

Sleep/Wake Regularity Associated with Default Mode Network Structure among Healthy Adolescents and Young Adults.

Journal Article Sci Rep · January 16, 2020 Sleep deprivation and disorders are linked to reduced DMN connectivity. Less is known about how naturalistic sleep patterns - specifically sleep irregularity - relate to the DMN, particularly among adolescents and young adults. Additionally, no studies hav ... Full text Link to item Cite

Cannabis use is associated with potentially heritable widespread changes in autism candidate gene DLGAP2 DNA methylation in sperm.

Journal Article Epigenetics · 2020 Parental cannabis use has been associated with adverse neurodevelopmental outcomes in offspring, but how such phenotypes are transmitted is largely unknown. Using reduced representation bisulphite sequencing (RRBS), we recently demonstrated that cannabis u ... Full text Open Access Link to item Cite

Smoking abstinence effects on emotion dysregulation in adult cigarette smokers with and without attention-deficit/hyperactivity disorder.

Journal Article Drug Alcohol Depend · December 1, 2019 BACKGROUND: Cigarette smoking is robustly associated with attention-deficit/hyperactivity disorder (ADHD), but little is known about psychological mechanisms accounting for this comorbid relationship. This study examined difficulties in emotion regulation, ... Full text Link to item Cite

Snacking frequency and dietary intake in toddlers and preschool children.

Journal Article Appetite · November 1, 2019 Understanding the relationship between snacking and dietary intake in early life years is one key but understudied area. In this study, we examined snacking patterns in toddlers and preschool children and the associations between snacking frequency and dai ... Full text Link to item Cite

Duration of Effect of a Novel, Home-Based, Digital Treatment for Pediatric ADHD

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2019 Full text Cite

The Many Channels of Screen Media Technology in ADHD: a Paradigm for Quantifying Distinct Risks and Potential Benefits.

Journal Article Curr Psychiatry Rep · August 13, 2019 PURPOSE OF REVIEW: Individuals with attention-deficit hyperactivity disorder (ADHD) may be unusually sensitive to screen media technology (SMT), from television to mobile devices. Although an association between ADHD and SMT use has been confirmed, its imp ... Full text Link to item Cite

Methylphenidate increases willingness to perform effort in adults with ADHD.

Journal Article Pharmacol Biochem Behav · August 2019 BACKGROUND: A reduced willingness to perform effort based on the magnitude and probability of potential rewards has been associated with diminished dopamine function and may be relevant to attention-deficit/hyperactivity disorder (ADHD). Here, we investiga ... Full text Link to item Cite

A generic algorithm for sleep-wake cycle detection using unlabeled actigraphy data

Conference 2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019 - Proceedings · May 1, 2019 One key component when analyzing actigraphy data for sleep studies is sleep-wake cycle detection. Most detection algorithms rely on accurate sleep diary labels to generate supervised classifiers, with parameters optimized for a particular dataset. However, ... Full text Cite

Cigarette Smoking Progression Among Young Adults Diagnosed With ADHD in Childhood: A 16-year Longitudinal Study of Children With and Without ADHD.

Journal Article Nicotine Tob Res · April 17, 2019 INTRODUCTION: Children with attention-deficit/hyperactivity disorder (ADHD) are at increased risk for smoking cigarettes, but there is little longitudinal research on the array of smoking characteristics known to be prognostic of long-term smoking outcomes ... Full text Link to item Cite

An Automated Text-Messaging Platform for Enhanced Retention and Data Collection in a Longitudinal Birth Cohort: Cohort Management Platform Analysis.

Journal Article JMIR Public Health Surveill · April 2, 2019 BACKGROUND: Traditional methods for recruiting and maintaining contact with participants in cohort studies include print-based correspondence, which can be unidirectional, labor intensive, and slow. Leveraging technology can substantially enhance communica ... Full text Link to item Cite

Eveningness diurnal preference associated with poorer socioemotional cognition and social functioning among healthy adolescents and young adults.

Journal Article Chronobiol Int · March 2019 Recently there has been growing interest in associations between sleep, emotion, and social functioning. Less is known about relationships between chronotype preference and socioemotional cognition and functioning, particularly among adolescents, who exper ... Full text Link to item Cite

Pre-Pregnancy Weight and Symptoms of Attention Deficit Hyperactivity Disorder and Executive Functioning Behaviors in Preschool Children.

Journal Article Int J Environ Res Public Health · February 25, 2019 This study examines pre-pregnancy Body Mass Index (BMI) and gestational weight gain (GWG) in relation to early childhood Attention Deficit Hyperactivity Disorder (ADHD) symptoms and related executive self-regulation behaviors. The analyses sample (n = 331) ... Full text Open Access Link to item Cite

Associations between imprinted gene differentially methylated regions, appetitive traits and body mass index in children.

Journal Article Pediatr Obes · February 2019 BACKGROUND: Knowledge regarding genetic influences on eating behaviours is expanding; yet less is known regarding contributions of epigenetic variation to appetitive traits and body mass index (BMI) in children. OBJECTIVE: The purpose of this study was to ... Full text Link to item Cite

Editorial Perspective: Delayed circadian rhythm phase: a cause of late-onset attention-deficit/hyperactivity disorder among adolescents?

Journal Article J Child Psychol Psychiatry · December 2018 Late-onset attention-deficit/hyperactivity disorder (ADHD) has been a topic of significant debate within our field. One question focuses on whether there may be alternative explanations for the onset of inattentive and/or hyperactive symptoms in adolescenc ... Full text Link to item Cite

4.15 The Efficacy and Safety of Methylphenidate Hydrochloride (HCL) Extended-Release in Preschool Aged Children With ADHD

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2018 Full text Cite

2.22 Lisdexamfetamine Dimesylate for Preschool Children With ADHD

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2018 Full text Cite

Validation of the Sleep Regularity Index in Older Adults and Associations with Cardiometabolic Risk.

Journal Article Sci Rep · September 21, 2018 Sleep disturbances, including insufficient sleep duration and circadian misalignment, confer risk for cardiometabolic disease. Less is known about the association between the regularity of sleep/wake schedules and cardiometabolic risk. This study evaluated ... Full text Open Access Link to item Cite

Reliability and Validity of the Daily Parent Rating of Evening and Morning Behavior Scale, Revised.

Journal Article J Atten Disord · September 2018 OBJECTIVE: Children with ADHD frequently manifest behavioral difficulties in the morning prior to school. We sought to assess the reliability and validity of the Daily Parent Rating of Evening and Morning Behavior Scale, Revised (DPREMB-R) morning score as ... Full text Link to item Cite

An Automated Text-Messaging Platform for Enhanced Retention and Data Collection in a Longitudinal Birth Cohort: Cohort Management Platform Analysis (Preprint)

Journal Article · July 23, 2018 BACKGROUNDTraditional methods for recruiting and maintaining contact with participants in cohort studies include print-based correspondence, which can be unidirectional, labor intensive, ... Full text Cite

Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes.

Journal Article Clin Epigenetics · July 20, 2018 BACKGROUND: Epigenetic modifications, including DNA methylation, act as one potential mechanism underlying the detrimental effects associated with prenatal tobacco smoke (PTS) exposure. Methylation in a gene called AXL was previously reported to differ in ... Full text Link to item Cite

How Substance Users With ADHD Perceive the Relationship Between Substance Use and Emotional Functioning.

Journal Article J Atten Disord · July 2018 OBJECTIVE: Although substance use (SU) is elevated in ADHD and both are associated with disrupted emotional functioning, little is known about how emotions and SU interact in ADHD. We used a mixed qualitative-quantitative approach to explore this relations ... Full text Link to item Cite

Associations between maternal cytokine levels during gestation and measures of child cognitive abilities and executive functioning.

Journal Article Brain Behav Immun · May 2018 Preclinical studies demonstrate that environmentally-induced alterations in inflammatory cytokines generated by the maternal and fetal immune system can significantly impact fetal brain development. Yet, the relationship between maternal cytokines during g ... Full text Link to item Cite

Maternal pre-pregnancy obesity and child neurodevelopmental outcomes: a meta-analysis.

Journal Article Obes Rev · April 2018 This review examined evidence of the association between maternal pre-pregnancy overweight/obesity status and child neurodevelopmental outcomes. PubMed and PsycINFO databases were systematically searched for empirical studies published before April 2017 us ... Full text Link to item Cite

Childhood ADHD Symptoms and Future Illicit Drug Use: The Role of Adolescent Cigarette Use.

Journal Article J Pediatr Psychol · March 1, 2018 OBJECTIVES: The aim of this study is to understand how early cigarette use might predict subsequent illicit drug use, especially among individuals with attention-deficit hyperactivity disorder (ADHD) symptoms during childhood. METHODS: Data were drawn from ... Full text Link to item Cite

ADHD, Smoking Withdrawal, and Inhibitory Control: Results of a Neuroimaging Study with Methylphenidate Challenge.

Journal Article Neuropsychopharmacology · March 2018 Smoking withdrawal negatively impacts inhibitory control, and these effects are greater for smokers with preexisting attention problems, such as attention deficit/hyperactivity disorder (ADHD). The current study preliminarily evaluated changes in inhibitor ... Full text Link to item Cite

Impact of Smoking Ban on Passive Smoke Exposure in Pregnant Non-Smokers in the Southeastern United States.

Journal Article Int J Environ Res Public Health · January 6, 2018 Prenatal passive smoke exposure raises risk for negative birth outcomes. Legislation regulating public smoking has been shown to impact exposure levels, though fewer studies involving pregnant women have been conducted within the U.S. where bans are incons ... Full text Link to item Cite

Proof-of-concept study of an at-home, engaging, digital intervention for pediatric ADHD.

Journal Article PLoS One · 2018 OBJECTIVE: Pharmacological and behavioral therapies have limited impact on the distinct neurocognitive impairments associated with ADHD, and existing cognitive training programs have shown limited efficacy. This proof-of-concept study assessed treatment ac ... Full text Link to item Cite

Cannabinoid exposure and altered DNA methylation in rat and human sperm.

Journal Article Epigenetics · 2018 Little is known about the reproductive effects of paternal cannabis exposure. We evaluated associations between cannabis or tetrahydrocannabinol (THC) exposure and altered DNA methylation in sperm from humans and rats, respectively. DNA methylation, measur ... Full text Open Access Link to item Cite

A Pilot Trial of Mindfulness Meditation Training for ADHD in Adulthood: Impact on Core Symptoms, Executive Functioning, and Emotion Dysregulation.

Journal Article J Atten Disord · November 2017 OBJECTIVE: Mindfulness meditation training is garnering increasing empirical interest as an intervention for ADHD in adulthood, although no studies of mindfulness as a standalone treatment have included a sample composed entirely of adults with ADHD or a c ... Full text Link to item Cite

Environment and Gametic Epigenetic Reprogramming.

Conference ENVIRONMENTAL AND MOLECULAR MUTAGENESIS · September 1, 2017 Link to item Cite

Maternal inflammatory diet and adverse pregnancy outcomes: Circulating cytokines and genomic imprinting as potential regulators?

Journal Article Epigenetics · August 2017 Excessive inflammation during pregnancy alters homeostatic mechanisms of the developing fetus and has been linked to adverse pregnancy outcomes. An anti-inflammatory diet could be a promising avenue to combat the pro-inflammatory state of pregnancy, partic ... Full text Link to item Cite

Efficacy, Safety, and Tolerability of an Extended-Release Orally Disintegrating Methylphenidate Tablet in Children 6-12 Years of Age with Attention-Deficit/Hyperactivity Disorder in the Laboratory Classroom Setting.

Journal Article J Child Adolesc Psychopharmacol · February 2017 OBJECTIVE: Methylphenidate extended-release orally disintegrating tablets (MPH XR-ODTs) represent a new technology for MPH delivery. ODTs disintegrate in the mouth without water and provide a pharmacokinetic profile that is consistent with once-daily dosin ... Full text Link to item Cite

Sleep disturbances in adolescents with ADHD: A systematic review and framework for future research.

Journal Article Clin Psychol Rev · December 2016 BACKGROUND: Biological mechanisms underlying symptom and prognostic heterogeneity in Attention-Deficit/Hyperactivity Disorder (ADHD) are unclear. Sleep impacts neurocognition and daytime functioning and is disrupted in ADHD, yet little is known about sleep ... Full text Link to item Cite

Topical Review: ADHD and Health-Risk Behaviors: Toward Prevention and Health Promotion.

Journal Article J Pediatr Psychol · August 2016 Across the lifespan, attention deficit/hyperactivity disorder (ADHD) is associated with increased health risk behaviors including substance abuse, binge eating and obesity, and unsafe sexual behavior. These risks are directly linked to the neurocognitive d ... Full text Link to item Cite

"I Use Weed for My ADHD": A Qualitative Analysis of Online Forum Discussions on Cannabis Use and ADHD.

Journal Article PLoS One · 2016 BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a risk factor for problematic cannabis use. However, clinical and anecdotal evidence suggest an increasingly popular perception that cannabis is therapeutic for ADHD, including via online resou ... Full text Open Access Link to item Cite

Dasotraline for the Treatment of Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind, Placebo-Controlled, Proof-of-Concept Trial in Adults.

Journal Article Neuropsychopharmacology · November 2015 Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by symptoms of inattention, hyperactivity, and impulsivity associated with clinically significant impairment in functioning. ADHD has an early onset, but frequen ... Full text Link to item Cite

Pharmacotherapy of the Preschool ADHD Treatment Study (PATS) Children Growing Up.

Journal Article J Am Acad Child Adolesc Psychiatry · July 2015 OBJECTIVE: To describe the long-term psychopharmacological treatment of children first diagnosed with attention-deficit/hyperactivity disorder (ADHD) as preschoolers. METHOD: In a systematic, prospective, naturalistic follow-up, 206 (68.0%) of the 303 chil ... Full text Link to item Cite

The Efficacy and Safety of Evekeo, Racemic Amphetamine Sulfate, for Treatment of Attention-Deficit/Hyperactivity Disorder Symptoms: A Multicenter, Dose-Optimized, Double-Blind, Randomized, Placebo-Controlled Crossover Laboratory Classroom Study.

Journal Article J Child Adolesc Psychopharmacol · June 2015 OBJECTIVE: The study goal was to determine the efficacy and safety of an optimal dose of Evekeo, racemic amphetamine sulfate, 1:1 d-amphetamine and l-amphetamine (R-AMPH), compared to placebo in treating children with attention-deficit/hyperactivity disord ... Full text Link to item Cite

Mindfulness Meditation Training for Attention-Deficit/Hyperactivity Disorder in Adulthood: Current Empirical Support, Treatment Overview, and Future Directions.

Journal Article Cogn Behav Pract · May 2015 Research examining nonpharmacological interventions for adults diagnosed with attention-deficit/hyperactivity disorder (ADHD) has expanded in recent years and provides patients with more treatment options. Mindfulness-based training is an example of an int ... Full text Link to item Cite

PRE-PREGNANCY OBESITY AND OFFSPRING NEUROBEHAVIORAL DEVELOPMENT

Journal Article ANNALS OF BEHAVIORAL MEDICINE · April 1, 2015 Link to item Cite

Attention Deficit Hyperactivity Disorder symptoms and smoking trajectories: race and gender differences.

Journal Article Drug Alcohol Depend · March 1, 2015 PURPOSE: This study examined the influence of Attention Deficit Hyperactivity Disorder (ADHD) symptoms severity and directionality (hyperactive-impulsive symptoms relative to inattentive symptoms) on trajectories of the probability of current (past month) ... Full text Link to item Cite

An exploratory study of the combined effects of orally administered methylphenidate and delta-9-tetrahydrocannabinol (THC) on cardiovascular function, subjective effects, and performance in healthy adults.

Journal Article J Subst Abuse Treat · January 2015 Methylphenidate (MPH) is commonly prescribed for the treatment of Attention Deficit Hyperactivity Disorder (ADHD), and is often used illicitly by young adults. Illicit users often coadminister MPH with marijuana. Little is known about physiologic and subje ... Full text Link to item Cite

Dasotraline for the treatment of attention-deficit/hyperactivity disorder: A randomized, double-blind, placebo-controlled, proof-of-concept trial in adults

Journal Article Neuropsychopharmacology · 2015 © 2015 American College of Neuropsychopharmacology.Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by symptoms of inattention, hyperactivity, and impulsivity associated with clinically significant impairment i ... Full text Cite

ADHD and smoking

Chapter · January 1, 2015 Introduction Cigarette smoking is the leading preventable cause of death and disability in the United States. Annually, smoking leads to more than 400 000 premature deaths in the USA and nearly 5 million deaths worldwide [1]. In the USA alone, $150 billion ... Full text Cite

Angiogenic, neurotrophic, and inflammatory system SNPs moderate the association between birth weight and ADHD symptom severity.

Journal Article Am J Med Genet B Neuropsychiatr Genet · December 2014 Low birth weight is associated with increased risk for Attention-Deficit/Hyperactivity Disorder (ADHD); however, the etiological underpinnings of this relationship remain unclear. This study investigated if genetic variants in angiogenic, dopaminergic, neu ... Full text Link to item Cite

A randomized placebo-controlled double-blind study evaluating the time course of response to methylphenidate hydrochloride extended-release capsules in children with attention-deficit/hyperactivity disorder.

Journal Article J Child Adolesc Psychopharmacol · December 2014 OBJECTIVE: The purpose of this study was to assess the time of onset and time course of efficacy over 12.0 hours of extended-release multilayer bead formulation of methylphenidate (MPH-MLR) compared with placebo in children 6-12 years of age with attention ... Full text Link to item Cite

Steady-state bioavailability of extended-release methylphenidate (MPH-MLR) capsule vs. immediate-release methylphenidate tablets in healthy adult volunteers.

Journal Article Clin Drug Investig · November 2014 OBJECTIVES: The objective of the study was to determine the relative bioavailability of an extended-release multilayer bead formulation of methylphenidate hydrochloride (MPH-MLR) 80 mg vs. methylphenidate immediate-release (IR; Ritalin(®)) tablets as singl ... Full text Link to item Cite

Ecological momentary assessment of antecedents and consequences of smoking in adults with attention-deficit/hyperactivity disorder.

Journal Article Subst Use Misuse · September 2014 The current study assessed antecedents and consequences of ad lib cigarette smoking in smokers diagnosed with attention-deficit/hyperactivity disorder (ADHD) using ecological momentary assessment (EMA). Adult smokers with ADHD (n = 17) completed 870 smokin ... Full text Link to item Cite

ADHD, altered dopamine neurotransmission, and disrupted reinforcement processes: implications for smoking and nicotine dependence.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · July 3, 2014 Attention deficit hyperactivity disorder (ADHD) is a common and impairing disorder affecting millions of children, adolescents, and adults. Individuals with ADHD smoke cigarettes at rates significantly higher than their non-diagnosed peers and the disorder ... Full text Link to item Cite

Stimulant treatment of ADHD and cigarette smoking: a meta-analysis.

Journal Article Pediatrics · June 2014 BACKGROUND AND OBJECTIVE: Individuals with attention-deficit/hyperactivity disorder (ADHD) have a significantly higher risk of cigarette smoking. The nature of the relationship between smoking and psychostimulant medications commonly used to treat ADHD is ... Full text Link to item Cite

Corners' rating scales-revised

Chapter · April 8, 2014 Cite

A pilot study of lis-dexamfetamine dimesylate (LDX/SPD489) to facilitate smoking cessation in nicotine-dependent adults with ADHD.

Journal Article J Atten Disord · February 2014 OBJECTIVE: The goal of this study was to assess the efficacy and tolerability of lis-dexamfetamine dimesylate (LDX) as an adjunct to nicotine replacement therapy in adult smokers with ADHD who were undergoing a quit attempt. METHODS: Thirty-two regular adu ... Full text Link to item Cite

Analysis of individual items on the attention-deficit/hyperactivity disorder symptom rating scale in children and adults: the effects of age and sex in pivotal trials of lisdexamfetamine dimesylate.

Journal Article Neuropsychiatr Dis Treat · 2014 BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) symptom presentation across age and sex has not been fully elucidated. The present post hoc analyses qualitatively explored the baseline levels of ADHD symptomatology across subgroups in two clini ... Full text Link to item Cite

Combined ecological momentary assessment and global positioning system tracking to assess smoking behavior: a proof of concept study.

Journal Article J Dual Diagn · 2014 OBJECTIVE: Ecological momentary assessment (EMA) methods have provided a rich assessment of the contextual factors associated with a wide range of behaviors including alcohol use, eating, physical activity, and smoking. Despite this rich database, this inf ... Full text Link to item Cite

Smoking motivation in adults with attention-deficit/hyperactivity disorder using the Wisconsin inventory of smoking dependence motives.

Journal Article Nicotine Tob Res · January 2014 INTRODUCTION: Smokers with attention-deficit/hyperactivity disorder (ADHD) differ from smokers without ADHD across a range of smoking outcomes (e.g., higher prevalence rates of smoking, faster progression to regular smoking, and greater difficulty quitting ... Full text Link to item Cite

Childhood economic strains in predicting substance use in emerging adulthood: mediation effects of youth self-control and parenting practices.

Journal Article J Pediatr Psychol · November 2013 OBJECTIVE: To examine the influence of childhood economic strains on substance use in young adulthood and to assess the mediating roles of self-control as well as positive parenting during adolescence in a nationally representative longitudinal cohort. MET ... Full text Link to item Cite

Nicotinic receptor gene variants interact with attention deficient hyperactive disorder symptoms to predict smoking trajectories from early adolescence to adulthood.

Journal Article Addict Behav · November 2013 OBJECTIVE: To examine the association of single nucleotide polymorphisms (SNPs) of the CHRNB3 (rs13280604) and CHRNA6 (rs892413) nicotinic acetylcholine receptor (nAChR) genes and symptoms of attention deficit hyperactivity disorder (ADHD) in predicting sm ... Full text Link to item Cite

Methylphenidate does not influence smoking-reinforced responding or attentional performance in adult smokers with and without attention deficit hyperactivity disorder (ADHD).

Journal Article Exp Clin Psychopharmacol · October 2013 Individuals with Attention Deficit Hyperactivity Disorder (ADHD) smoke cigarettes at rates higher than the general population and questions have been raised about how stimulant drugs-the frontline pharmacological treatment for ADHD-influence smoking risk a ... Full text Link to item Cite

Individual- and community-level correlates of cigarette-smoking trajectories from age 13 to 32 in a U.S. population-based sample.

Journal Article Drug Alcohol Depend · September 1, 2013 BACKGROUND: Characterizing smoking behavior is important for informing etiologic models and targeting prevention efforts. This study explored the effects of both individual- and community-level variables in predicting cigarette use vs. non-use and level of ... Full text Link to item Cite

Effects of smoking abstinence on smoking-reinforced responding, withdrawal, and cognition in adults with and without attention deficit hyperactivity disorder.

Journal Article Psychopharmacology (Berl) · May 2013 RATIONALE: Individuals with attention deficit hyperactivity disorder (ADHD) have a more difficult time quitting smoking compared to their non-ADHD peers. Little is known about the underlying behavioral mechanisms associated with this increased risk. OBJECT ... Full text Link to item Cite

The Preschool Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS) 6-year follow-up.

Journal Article J Am Acad Child Adolesc Psychiatry · March 2013 OBJECTIVE: To describe the clinical course of attention-deficit/hyperactivity disorder (ADHD) symptom severity and diagnosis from ages 3 to 5 up to 9 to 12 years during a 6-year follow-up after the original Preschool ADHD Treatment Study (PATS). METHOD: A ... Full text Link to item Cite

ADHD in adolescence

Chapter · 2013 Cite

Long-term stimulant treatment affects brain dopamine transporter level in patients with attention deficit hyperactive disorder.

Journal Article PLoS One · 2013 OBJECTIVE: Brain dopamine dysfunction in attention deficit/hyperactivity disorder (ADHD) could explain why stimulant medications, which increase dopamine signaling, are therapeutically beneficial. However while the acute increases in dopamine induced by st ... Full text Link to item Cite

Emotion dysregulation and emotional impulsivity among adults with attention-deficit/hyperactivity disorder: Results of a preliminary study

Journal Article Journal of Psychopathology and Behavioral Assessment · December 1, 2012 Recent reviews argue that emotion dysregulation is an important feature of attention-deficit/hyperactivity disorder (ADHD) and involves a failure to inhibit negative emotions that leads to negative affectively-driven impulsive behavior (i.e., emotional imp ... Full text Cite

Assessing the role of attention-deficit/hyperactivity disorder symptoms in smokers with and without posttraumatic stress disorder.

Journal Article Nicotine Tob Res · August 2012 INTRODUCTION: Smoking prevalence among individuals with posttraumatic stress disorder (PTSD) is elevated relative to non-PTSD smokers, and there is evidence to suggest that affect regulation may be a motivation for smoking among those with this disorder. P ... Full text Link to item Cite

Treatment for co-occurring attention deficit/hyperactivity disorder and autism spectrum disorder.

Journal Article Neurotherapeutics · July 2012 Interest in the co-occurrence of attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) has grown in the last decade. Research on clinical populations supports the frequent co-occurrence of ADHD traits (e.g., hyperactivity) in i ... Full text Link to item Cite

Efficacy of guanfacine extended release in the treatment of combined and inattentive only subtypes of attention-deficit/hyperactivity disorder.

Journal Article J Child Adolesc Psychopharmacol · June 2012 BACKGROUND: Extended-release guanfacine (GXR) is approved for the treatment of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents aged 6-17 years. This post-hoc analysis further examines the effects of GXR on hyperactivity-impulsiv ... Full text Link to item Cite

Sex, ADHD symptoms, and smoking outcomes: an integrative model.

Journal Article Med Hypotheses · May 2012 Both females and individuals with Attention-Deficit/Hyperactivity Disorder (ADHD) have been found to be at increased risk for a range of smoking outcomes, and recent empirical findings have suggested that women with ADHD may be particularly vulnerable to n ... Full text Link to item Cite

Dose response effects of lisdexamfetamine dimesylate treatment in adults with ADHD: an exploratory study.

Journal Article J Atten Disord · February 2012 OBJECTIVE: To explore dose-response effects of lisdexamfetamine dimesylate (LDX) treatment for ADHD. METHOD: This was a 4-week, randomized, double-blinded, placebo-controlled, parallel-group, forced-dose titration study in adult participants, aged 18 to 55 ... Full text Link to item Cite

A preliminary analysis of interactions between genotype, retrospective ADHD symptoms, and initial reactions to smoking in a sample of young adults.

Journal Article Nicotine Tob Res · February 2012 INTRODUCTION: Initial reactions to cigarettes predict later regular smoking. Symptoms of attention deficit hyperactivity disorder (ADHD) have also been shown to increase smoking risk and may moderate the relationship between genotype and smoking. We conduc ... Full text Link to item Cite

An examination of differences in variables maintaining smoking behavior in adult smokers with and without attention-deficit/hyperactivity disorder

Journal Article Addiction Research and Theory · February 1, 2012 Individuals with attention-deficit/hyperactivity disorder (ADHD) smoke cigarettes at higher rates and have greater difficulty quitting than their non-diagnosed peers. This study examined differences between smokers with and without ADHD on a range of smoki ... Full text Cite

Methylphenidate-elicited dopamine increases in ventral striatum are associated with long-term symptom improvement in adults with attention deficit hyperactivity disorder.

Journal Article J Neurosci · January 18, 2012 Stimulant medications, such as methylphenidate, which are effective treatments for attention deficit hyperactivity disorder (ADHD), enhance brain dopamine signaling. However, the relationship between regional brain dopamine enhancement and treatment respon ... Full text Link to item Cite

Understanding the phenotypic structure of adult retrospective ADHD symptoms during childhood in the United States.

Journal Article J Clin Child Adolesc Psychol · 2012 Attention-deficit/hyperactivity disorder (ADHD) is a highly heterogeneous disorder, and the phenotypic structure comprising inattentive and hyperactive-impulsive type symptoms has been the focus of a growing body of recent research. Methodological studies ... Full text Link to item Cite

Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway.

Journal Article Mol Psychiatry · November 2011 Featured Publication Attention-deficit hyperactivity disorder (ADHD) is typically characterized as a disorder of inattention and hyperactivity/impulsivity but there is increasing evidence of deficits in motivation. Using positron emission tomography (PET), we showed decreased ... Full text Link to item Cite

Self-Regulation of Emotion, Functional Impairment, and Comorbidity Among ChildrenWith AD/HD.

Journal Article J Atten Disord · October 2011 OBJECTIVE: This study investigated the role of self-regulation of emotion in relation to functional impairment and comorbidity among children with and without AD/HD. METHOD: A total of 358 probands and their siblings participated in the study, with 74% of ... Full text Link to item Cite

Smoking withdrawal symptoms are more severe among smokers with ADHD and independent of ADHD symptom change: results from a 12-day contingency-managed abstinence trial.

Journal Article Nicotine Tob Res · September 2011 Featured Publication INTRODUCTION: Smokers with attention deficit hyperactivity disorder (ADHD) have greater difficulty quitting than those without ADHD, but preliminary data (McClernon, Kollins, Lutz, Fitzgerald, Murray, Redman, et al., 2008) suggest equivalent severity of wi ... Full text Link to item Cite

Cognitive enhancers for the treatment of ADHD.

Journal Article Pharmacol Biochem Behav · August 2011 Attention-deficit hyperactivity disorder (ADHD) is associated with multiple cognition-related phenotypic features in both children and adults. This review aims to clarify the role of cognition in ADHD and how prevailing treatments, which are often highly e ... Full text Link to item Cite

Clonidine extended-release tablets as add-on therapy to psychostimulants in children and adolescents with ADHD.

Journal Article Pediatrics · June 2011 Featured Publication OBJECTIVE: To assess the efficacy and safety of clonidine hydrochloride extended-release tablets (CLON-XR) combined with stimulants (ie, methylphenidate or amphetamine) for attention-deficit/hyperactivity disorder (ADHD). PATIENTS AND METHODS: In this phas ... Full text Link to item Cite

Association between attention-deficit/hyperactivity disorder symptoms and obesity and hypertension in early adulthood: a population-based study.

Journal Article Int J Obes (Lond) · June 2011 Featured Publication OBJECTIVE: To examine the associations between attention-deficit/hyperactivity disorder (ADHD) symptoms, obesity and hypertension in young adults in a large population-based cohort. DESIGN, SETTING AND PARTICIPANTS: The study population consisted of 15,197 ... Full text Open Access Link to item Cite

Reliability and validity of self- and other-ratings of symptoms of ADHD in adults.

Journal Article J Atten Disord · April 2011 Featured Publication OBJECTIVE: Few studies have examined concordance between raters of ADHD symptoms in adults; there is less information on how well rating scales function in distinguishing adult ADHD from other disorders. This study examined these variables using the Conner ... Full text Link to item Cite

Psychomotor functioning and alertness with guanfacine extended release in subjects with attention-deficit/hyperactivity disorder.

Journal Article J Child Adolesc Psychopharmacol · April 2011 Featured Publication OBJECTIVES: To determine whether treatment with guanfacine extended release (GXR) in subjects with attention-deficit/hyperactivity disorder (ADHD) disrupted psychomotor functioning and alertness, or impacted daytime sleepiness. METHOD: This was a randomize ... Full text Link to item Cite

A double-blind, placebo-controlled study of atomoxetine in young children with ADHD.

Journal Article Pediatrics · April 2011 OBJECTIVE: To evaluate the efficacy and tolerability of atomoxetine for the treatment of attention-deficit/hyperactivity disorder (ADHD) in 5- and 6-year-old children. METHODS: This was an 8-week, double-blind, placebo-controlled randomized clinical trial ... Full text Link to item Cite

The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjects.

Journal Article Am J Med Genet B Neuropsychiatr Genet · March 2011 Intelligence is a highly heritable trait for which it has proven difficult to identify the actual genes. In the past decade, five whole-genome linkage scans have suggested genomic regions important to human intelligence; however, so far none of the respons ... Full text Link to item Cite

Corrigendum

Journal Article Journal of the American Academy of Child & Adolescent Psychiatry · March 2011 Full text Cite

Clonidine extended-release tablets for pediatric patients with attention-deficit/hyperactivity disorder.

Journal Article J Am Acad Child Adolesc Psychiatry · February 2011 OBJECTIVE: This study examined the efficacy and safety of clonidine hydrochloride extended-release tablets (CLON-XR) in children and adolescents with attention-deficit/hyperactivity disorder (ADHD). METHOD: This 8-week, placebo-controlled, fixed-dose trial ... Full text Link to item Cite

Lisdexamfetamine dimesylate for the treatment of attention deficit hyperactivity disorder in adults with a history of depression or history of substance use disorder.

Journal Article Innov Clin Neurosci · February 2011 OBJECTIVE: To evaluate the efficacy and safety of lisdexamfetamine dimesylate in participants with attention deficit hyperactivity disorder and a history of depression and/or substance use disorder. History of these comorbidities was recorded from medical ... Link to item Cite

Abuse potential of stimulant drugs used to treat ADHD

Chapter · January 1, 2011 The use of psychostimulants and, more recently, other classes of drugs for the treatment of attention-deficit hyperactivity disorder (ADHD) is widespread. Although it is generally agreed that use in the United States is higher than in other countries, evid ... Full text Cite

Efficacy and tolerability of lisdexamfetamine dimesylate in children with attention-deficit/hyperactivity disorder: sex and age effects and effect size across the day.

Journal Article Child Adolesc Psychiatry Ment Health · December 14, 2010 BACKGROUND: Efficacy and safety profiles by sex and age (6-9 vs 10-12 years) and magnitude and duration of effect by effect size overall and across the day of lisdexamfetamine dimesylate (LDX) vs placebo were assessed. METHODS: This study enrolled children ... Full text Link to item Cite

Lisdexamfetamine dimesylate: a new option in stimulant treatment for ADHD.

Journal Article Expert Opin Pharmacother · December 2010 IMPORTANCE OF THE FIELD: Attention deficit/hyperactivity disorder (ADHD), a prevalent disorder in children and adults, presents a substantial societal burden in both monetary cost and human suffering. Characterized by significant difficulties in maintainin ... Full text Link to item Cite

Smoking withdrawal modulates right inferior frontal cortex but not presupplementary motor area activation during inhibitory control.

Journal Article Neuropsychopharmacology · December 2010 Featured Publication Smokers exhibit decrements in inhibitory control (IC) during withdrawal. The objective of this study was to investigate the neural basis of these effects in critical substrates of IC--right inferior frontal cortex (rIFC) and presupplementary motor area (pr ... Full text Link to item Cite

Alpha-2 adrenergic receptors and attention-deficit/hyperactivity disorder.

Journal Article Curr Psychiatry Rep · October 2010 Pharmacologic management of attention-deficit/hyperactivity disorder (ADHD) has expanded beyond stimulant medications to include alpha-2 adrenergic agonists. These agents exert their actions through presynaptic stimulation and likely involve facilitation o ... Full text Link to item Cite

Effects of guanfacine extended release on oppositional symptoms in children aged 6-12 years with attention-deficit hyperactivity disorder and oppositional symptoms: a randomized, double-blind, placebo-controlled trial.

Journal Article CNS Drugs · September 2010 OBJECTIVE: To evaluate the efficacy and safety of guanfacine extended release (XR, Intuniv; Shire Development Inc., Wayne, PA, USA) in the treatment of oppositional symptoms in children aged 6-12 years with a diagnosis of attention-deficit hyperactivity di ... Full text Link to item Cite

Monetary incentives promote smoking abstinence in adults with attention deficit hyperactivity disorder (ADHD).

Journal Article Exp Clin Psychopharmacol · June 2010 Featured Publication Individuals with attention deficit hyperactivity disorder (ADHD) smoke at rates significantly higher than the general population and have more difficulty quitting than nondiagnosed individuals. Currently, there are no evidence-based approaches for reducing ... Full text Link to item Cite

Subjective Effects of Methylphenidate

Journal Article · April 1, 2010 Methylphenidate (MPH) is one of the most widely prescribed psychotropic agents in the United States, and its increased use over the past two decades has been a source of growing controversy among scientists, clinicians, policy makers, and parents. This cha ... Full text Cite

Genetic variants in SLC9A9 are associated with measures of attention-deficit/hyperactivity disorder symptoms in families.

Journal Article Psychiatr Genet · April 2010 OBJECTIVE: A family was previously identified that cosegregates a pericentric inversion, inv(3)(p14 : q21), with an early-onset developmental condition, characterized by impulsive behavior and intellectual deficit. The inversion breakpoints lie within DOCK ... Full text Link to item Cite

Implications of Extending the ADHD Age-of-Onset Criterion to Age 12

Journal Article Journal of the American Academy of Child & Adolescent Psychiatry · March 2010 Full text Cite

Implications of extending the ADHD age-of-onset criterion to age 12: results from a prospectively studied birth cohort.

Journal Article J Am Acad Child Adolesc Psychiatry · March 2010 OBJECTIVE: To evaluate whether including children with onset of symptoms between ages 7 and 12 years in the ADHD diagnostic category would: (a) increase the prevalence of the disorder at age 12, and (b) change the clinical and cognitive features, impairmen ... Link to item Cite

Effects of lisdexamfetamine dimesylate treatment for ADHD on growth.

Journal Article J Am Acad Child Adolesc Psychiatry · January 2010 OBJECTIVE: To complete an exploratory uncontrolled study of the effects of lisdexamfetamine dimesylate (LDX) on growth of children treated for attention-deficit/hyperactivity disorder (ADHD). METHOD: Height, weight, and body mass index (BMI) from 281 child ... Full text Link to item Cite

Evaluating Dopamine Reward Pathway in ADHD: Clinical Implications (vol 302, pg 1084, 2009)

Journal Article JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION · October 7, 2009 Link to item Cite

Evaluating dopamine reward pathway in ADHD: clinical implications.

Journal Article JAMA · September 9, 2009 Featured Publication CONTEXT: Attention-deficit/hyperactivity disorder (ADHD)--characterized by symptoms of inattention and hyperactivity-impulsivity--is the most prevalent childhood psychiatric disorder that frequently persists into adulthood, and there is increasing evidence ... Full text Link to item Cite

A 13-hour laboratory school study of lisdexamfetamine dimesylate in school-aged children with attention-deficit/hyperactivity disorder.

Journal Article Child Adolesc Psychiatry Ment Health · June 9, 2009 BACKGROUND: Lisdexamfetamine dimesylate (LDX) is indicated for the treatment of attention-deficit/hyperactivity disorder (ADHD) in children 6 to 12 years of age and in adults. In a previous laboratory school study, LDX demonstrated efficacy 2 hours postdos ... Full text Link to item Cite

Effects of postnatal parental smoking on parent and teacher ratings of ADHD and oppositional symptoms.

Journal Article J Nerv Ment Dis · June 2009 Featured Publication To assess the effects of postnatal parental smoking on subsequent parent and teacher ratings of DSM-IV attention deficit hyperactivity disorder (ADHD) symptoms and oppositional behaviors in children diagnosed with ADHD and their siblings. Children between ... Full text Link to item Cite

Reinforcing and subjective effects of methylphenidate in adults with and without attention deficit hyperactivity disorder (ADHD).

Journal Article Psychopharmacology (Berl) · May 2009 Featured Publication RATIONALE: There has been controversy over the abuse potential of methylphenidate (MPH) in the context of treatment for attention deficit hyperactivity disorder (ADHD). OBJECTIVE: The objective of this study was to compare the reinforcing and subjective ef ... Full text Link to item Cite

Interactions between genotype and depressive symptoms on obesity.

Journal Article Behav Genet · May 2009 Depression and Genetic variation in serotonin and monoamine transmission have both been associated with body mass index (BMI), but their interaction effects are not well understood. We examined the interaction between depressive symptoms and functional pol ... Full text Link to item Cite

Association between smoking and retrospectively reported attention-deficit/hyperactivity disorder symptoms in a large sample of new mothers.

Journal Article Nicotine Tob Res · March 2009 INTRODUCTION: This study investigated the association between retrospectively reported attention-deficit/hyperactivity disorder (ADHD) symptoms experienced during childhood and five cigarette smoking-related outcomes in adulthood. METHODS: A large sample ( ... Full text Link to item Cite

Effects of smoking abstinence on reaction time variability in smokers with and without ADHD: an ex-Gaussian analysis.

Journal Article Drug Alcohol Depend · February 1, 2009 Featured Publication Smoking abstinence differentially affects cognitive functioning in smokers with ADHD, compared to non-ADHD smokers. Alternative approaches for analyzing reaction time data from these tasks may further elucidate important group differences. Adults smoking > ... Full text Link to item Cite

SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families.

Journal Article Am J Med Genet B Neuropsychiatr Genet · December 5, 2008 Haplotype-tagging SNP analyses were conducted to identify molecular genetic substrates of quantitative phenotypes derived from performance on a Continuous Performance Task (CPT). Three hundred sixty-four individuals were sampled from 152 families ascertain ... Full text Link to item Cite

Methylphenidate and amphetamine do not induce cytogenetic damage in lymphocytes of children with ADHD.

Journal Article J Am Acad Child Adolesc Psychiatry · December 2008 OBJECTIVE: In response to previously published findings of methylphenidate-induced chromosomal changes in children, this study was designed to determine whether methylphenidate- or amphetamine-based drugs induce chromosomal damage (structural aberrations, ... Full text Link to item Cite

ADHD and smoking: from genes to brain to behavior.

Journal Article Ann N Y Acad Sci · October 2008 Attention-deficit/hyperactivity disorder (ADHD) and tobacco smoking are among the most common and costly psychiatric and behavioral problems. The rates of co-occurrence of these two common problems are larger than expected by chance. Despite progress in id ... Full text Link to item Cite

Double-blind, placebo-controlled study of the efficacy and safety of lisdexamfetamine dimesylate in adults with attention-deficit/hyperactivity disorder.

Journal Article J Clin Psychiatry · September 2008 OBJECTIVE: To evaluate the efficacy and safety of 30, 50, and 70 mg/day lisdexamfetamine dimesylate compared with placebo in adults with attention-deficit/hyperactivity disorder (ADHD). METHOD: Following a 7- to 28-day washout, 420 adults aged 18 to 55 yea ... Full text Link to item Cite

ADHD, substance use disorders, and psychostimulant treatment: current literature and treatment guidelines.

Journal Article J Atten Disord · September 2008 OBJECTIVE: This review explores the relationship between ADHD and substance use disorder (SUD), factors that determine the abuse potential of psychostimulants, and strategies for identifying and treating at-risk ADHD patients. METHOD: This study uses a Med ... Full text Link to item Cite

A qualitative review of issues arising in the use of psycho-stimulant medications in patients with ADHD and co-morbid substance use disorders.

Journal Article Curr Med Res Opin · May 2008 OBJECTIVE: This review addresses the relationship between attention-deficit/hyperactivity disorder (ADHD) and substance use disorders (SUDs), with an emphasis on factors that determine the potential for psychostimulant abuse. Strategies for identification ... Full text Link to item Cite

Effects of smoking abstinence on adult smokers with and without attention deficit hyperactivity disorder: results of a preliminary study.

Journal Article Psychopharmacology (Berl) · March 2008 RATIONALE: Individuals with attention deficit hyperactivity disorder (ADHD) smoke at higher rates than the general population; however, little is known about the mechanisms underlying this comorbidity. OBJECTIVE: This study evaluated the effects of overnig ... Full text Link to item Cite

Genes implicated in serotonergic and dopaminergic functioning predict BMI categories.

Journal Article Obesity (Silver Spring) · February 2008 OBJECTIVE: This study addressed the hypothesis that variation in genes associated with dopamine function (SLC6A3, DRD2, DRD4), serotonin function (SLC6A4, and regulation of monoamine levels (MAOA) may be predictive of BMI categories (obese and overweight + ... Full text Link to item Cite

Interactions between genotype and retrospective ADHD symptoms predict lifetime smoking risk in a sample of young adults.

Journal Article Nicotine Tob Res · January 2008 Attention-deficit/hyperactivity disorder (ADHD) symptoms are associated with an increased risk of smoking, and genetic studies have identified similar candidate genes associated with both ADHD and smoking phenotypes. This paper addresses the question of wh ... Full text Link to item Cite

Psychosocial treatments for preschool-aged children with Attention-Deficit Hyperactivity Disorder.

Journal Article Dev Disabil Res Rev · 2008 This article reviews the research literature on psychosocial treatments for preschool-aged children with Attention-Deficit Hyperactivity Disorder (ADHD) in the context of the developmental and contextual needs of this population (e.g., increased parenting ... Full text Link to item Cite

Methylphenidate effects on functional outcomes in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS).

Journal Article J Child Adolesc Psychopharmacol · October 2007 OBJECTIVE: The purpose of this study was to examine the effects of methylphenidate (MPH) on functional outcomes, including children's social skills, classroom behavior, emotional status, and parenting stress, during the 4-week, double-blind placebo control ... Full text Link to item Cite

Effectiveness of methylphenidate in the 10-month continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS).

Journal Article J Child Adolesc Psychopharmacol · October 2007 OBJECTIVE: The aim of this study was to examine immediate-release methylphenidate effectiveness during the 10-month open-label continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder (ADHD) Treatment Study (PATS). METHODS: One ... Full text Link to item Cite

Parent versus teacher ratings of attention-deficit/hyperactivity disorder symptoms in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS).

Journal Article J Child Adolesc Psychopharmacol · October 2007 OBJECTIVE: To assess parent-teacher concordance on ratings of DSM-IV symptoms of attention-deficit/hyperactivity disorder (ADHD) in a sample of preschool children referred for an ADHD treatment study. METHODS: Parent and teacher symptom ratings were compar ... Full text Link to item Cite

Factor structure of parent- and teacher-rated attention-deficit/hyperactivity disorder symptoms in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS).

Journal Article J Child Adolesc Psychopharmacol · October 2007 OBJECTIVE: This study examines one-, two-, and three-factor models of attention-deficit/hyperactivity disorder (ADHD) using the existing 18 Diagnostic and Statistical Manual of Mental Disorder, 4th edition (DSM-IV) symptoms in a sample of symptomatic presc ... Full text Link to item Cite

Effects of source of DNA on genotyping success rates and allele percentages in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS).

Journal Article J Child Adolesc Psychopharmacol · October 2007 OBJECTIVE: In children diagnosed with attention-deficit/hyperactivity disorder (ADHD) and their parents, who were participants of the Preschool ADHD Treatment Study (PATS), we assessed the effect of source of DNA (from buccal or blood cells) on the genotyp ... Full text Link to item Cite

Comorbidity moderates response to methylphenidate in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS).

Journal Article J Child Adolesc Psychopharmacol · October 2007 OBJECTIVE: The aim of this study was to examine whether demographic or pretreatment clinical and social characteristics influenced the response to methylphenidate (MPH) in the Preschoolers with ADHD Treatment Study (PATS). METHODS: Exploratory moderator an ... Full text Link to item Cite

Increases in impulsivity following smoking abstinence are related to baseline nicotine intake and boredom susceptibility.

Journal Article Addict Behav · October 2007 Trait impulsivity and response inhibition have been shown to be related to smoking behavior. One measure of response inhibition - antisaccade performance, or the ability to inhibit looking at a novel stimulus - has been shown to be worsened by smoking abst ... Full text Link to item Cite

Clinical presentation of attention-deficit/hyperactivity disorder in preschool children: the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS).

Journal Article J Child Adolesc Psychopharmacol · October 2007 OBJECTIVE: The aim of this study was to describe the clinical presentation of preschoolers diagnosed with moderate to severe attention-deficit/hyperactivity disorder (ADHD) recruited for the multisite Preschool ADHD Treatment Study (PATS). The diagnosis an ... Full text Link to item Cite

A pilot study of atomoxetine in young children with attention-deficit/hyperactivity disorder.

Journal Article J Child Adolesc Psychopharmacol · April 2007 OBJECTIVE: The purpose of this study was to assess the effectiveness and tolerability of atomoxetine during acute treatment of attention-deficit/hyperactivity disorder (ADHD) in 5 and 6 year olds. METHOD: Twenty two children (male n = 19, 86%) with ADHD we ... Full text Link to item Cite

ADHD and Sustance Abuse Update

Journal Article The American Journal on Addictions · January 2, 2007 Full text Cite

Abuse liability of medications used to treat attention-deficit/hyperactivity disorder (ADHD).

Journal Article Am J Addict · 2007 The use of psychostimulants to treat attention-deficit/hyperactivity disorder (ADHD) has been controversial for a number of reasons. In an effort to clarify the extent to which the psychostimulant methylphenidate has abuse potential, the existing published ... Full text Link to item Cite

Attention deficit hyperactivity disorder symptoms predict nicotine dependence and progression to regular smoking from adolescence to young adulthood.

Journal Article J Pediatr Psychol · 2007 OBJECTIVE: To examine the association between retrospectively reported attention deficit hyperactivity disorder (ADHD) symptoms and progression to smoking and the association with nicotine dependence. METHODS: Study sample consisted of a nationally represe ... Full text Link to item Cite

Stimulant-related reductions of growth rates in the PATS.

Journal Article J Am Acad Child Adolesc Psychiatry · November 2006 OBJECTIVE: To investigate growth of children with attention-deficit/hyperactivity disorder (ADHD) in the Preschool ADHD Treatment Study (PATS) before and after initiation of treatment with methylphenidate at titrated doses (average, 14.2 mg/day) administer ... Full text Link to item Cite

Efficacy and safety of immediate-release methylphenidate treatment for preschoolers with ADHD.

Journal Article J Am Acad Child Adolesc Psychiatry · November 2006 OBJECTIVE: The Preschool ADHD Treatment Study (PATS) was a NIMH-funded, six-center, randomized, controlled trial to determine the efficacy and safety of immediate-release methylphenidate (MPH-IR), given t.i.d. to children ages 3 to 5.5 years with attention ... Full text Link to item Cite

Safety and tolerability of methylphenidate in preschool children with ADHD.

Journal Article J Am Acad Child Adolesc Psychiatry · November 2006 OBJECTIVE: To report on the safety and tolerability of methylphenidate (MPH) 3- to 5-year-old children with attention-deficit/hyperactivity disorder (ADHD) during 1 year of treatment. METHOD: Exactly 183 children (3-5 years old) entered a treatment study o ... Full text Link to item Cite

Rationale, design, and methods of the Preschool ADHD Treatment Study (PATS).

Journal Article J Am Acad Child Adolesc Psychiatry · November 2006 OBJECTIVE: To describe the rationale and design of the Preschool ADHD Treatment Study (PATS). METHOD: PATS was a National Institutes of Mental Health-funded, multicenter, randomized, efficacy trial designed to evaluate the short-term (5 weeks) efficacy and ... Full text Link to item Cite

Pharmacogenetics of methylphenidate response in preschoolers with ADHD.

Journal Article J Am Acad Child Adolesc Psychiatry · November 2006 OBJECTIVE: The authors explored genetic moderators of symptom reduction and side effects in methylphenidate-treated preschool-age children diagnosed with attention-deficit/hyperactivity disorder (ADHD). METHOD: DNA was isolated from 81 subjects in a double ... Full text Link to item Cite

Genetic associations with reaction time variability in AD/HD

Conference AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS · October 5, 2006 Link to item Cite

Psychometric properties of an adult ADHD diagnostic interview.

Journal Article J Atten Disord · February 2006 Although research has been conducted to support the psychometric properties of rating scales used to assess ADHD in adults, little work has been published examining semi-structured interviews to assess ADHD in adults. The present study examined the test-re ... Full text Link to item Cite

Evidence base for the use of stimulant medication in preschool children with ADHD

Journal Article Infants and Young Children · January 1, 2006 Increasingly, attention-deficit/hyperactivity disorder (ADHD) is being recognized as a valid disorder in preschool-aged children. There are only limited data available, however, to provide useful guidelines for the pharmacological management of this impair ... Full text Cite

A pilot study of methylphenidate preference assessment in children diagnosed with attention-deficit/hyperactivity disorder.

Journal Article J Child Adolesc Psychopharmacol · October 2005 OBJECTIVE: The use of methylphenidate (MPH) in the treatment of attention-deficit/hyperactivity disorder (ADHD) is widely accepted; however, there is increased concern regarding its abuse potential. Few studies have examined the reinforcing effects of drug ... Full text Link to item Cite

Association between smoking and attention-deficit/hyperactivity disorder symptoms in a population-based sample of young adults.

Journal Article Arch Gen Psychiatry · October 2005 Featured Publication CONTEXT: Attention-deficit/hyperactivity disorder (ADHD) has been associated with increased risk of smoking, and some studies have suggested that inattentive symptoms specifically may underlie this risk. Few studies, however, have examined ADHD symptoms in ... Full text Link to item Cite

A laboratory school comparison of mixed amphetamine salts extended release (Adderall XR) and atomoxetine (Strattera) in school-aged children with attention deficit/hyperactivity disorder.

Journal Article J Atten Disord · August 2005 Mixed amphetamine salts extended release (MAS XR; Adderall XR) and atomoxetine (Strattera) were compared in children 6 to 12 years old with attention deficit/hyperactivity disorder (ADHD) combined or hyperactive/impulsive type in a randomized, double-blind ... Full text Link to item Cite

Assessing methylphenidate preference in ADHD patients using a choice procedure.

Journal Article Psychopharmacology (Berl) · October 2004 RATIONALE: Methylphenidate (MPH) is widely used in the treatment of attention deficit hyperactivity disorder (ADHD) and is associated with positive clinical effects across a wide range of domains. Despite the clinical effectiveness of MPH, concern has aris ... Full text Link to item Cite

The genetics of AD/HD: Subtyping, comorbidity and developmental considerations

Conference AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS · September 15, 2004 Link to item Cite

A comparison of once-daily extended-release methylphenidate formulations in children with attention-deficit/hyperactivity disorder in the laboratory school (the Comacs Study).

Journal Article Pediatrics · March 2004 OBJECTIVE: The objective of this study was to evaluate differences in the pharmacodynamic (PD) profile of 2 second-generation extended-release (ER) formulations of methylphenidate (MPH): Metadate CD (MCD; methylphenidate HCl, US Pharmacopeia) extended-rele ... Full text Link to item Cite

Delay discounting is associated with substance use in college students.

Journal Article Addict Behav · August 2003 This study investigated whether a measure of delay discounting was associated with substance use variables in a sample of college students. Participants (N=47) completed a substance use survey and a delay-discounting measure that asked them to make a serie ... Full text Link to item Cite

Comparing the abuse potential of methylphenidate versus other stimulants: a review of available evidence and relevance to the ADHD patient.

Journal Article J Clin Psychiatry · 2003 The use of psychostimulants to treat attention-deficit/hyperactivity disorder (ADHD) has been controversial for a number of reasons. In an effort to clarify the extent to which the psychostimulant methylphenidate has abuse potential, the existing published ... Link to item Cite

Sensitization to the cardiovascular but not subject-rated effects of oral cocaine in humans.

Journal Article Biol Psychiatry · January 15, 2002 BACKGROUND: Despite a substantial nonhuman literature in the area, few studies have experimentally evaluated the effects of repeated stimulant administration in human participants. This study examined the effects of repeated cocaine in individuals with his ... Full text Link to item Cite

Assessing the abuse potential of methylphenidate in nonhuman and human subjects: a review.

Journal Article Pharmacol Biochem Behav · March 2001 Methylphenidate (MPH) is widely used for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in children, adolescents, and adults. Methylphenidate is clearly effective for the treatment of ADHD, but there is controversy as to whether it has si ... Full text Link to item Cite

Temporal discounting: basic research and the analysis of socially important behavior.

Journal Article J Appl Behav Anal · 2001 Recent basic research on human temporal discounting is reviewed to illustrate procedures, summarize key findings, and draw parallels with both nonhuman animal research and conceptual writings on self-control. Lessons derived from this research are then app ... Full text Link to item Cite

Effects of methylphenidate on sensitivity to reinforcement in children diagnosed with attention deficit hyperactivity disorder: an application of the matching law.

Journal Article J Appl Behav Anal · 2000 The behavior of children diagnosed with attention deficit hyperactivity disorder (ADHD) has been hypothesized to be the result of decreased sensitivity to consequences compared to typical children. The present study examined sensitivity to reinforcement in ... Full text Link to item Cite

The good, the bad, and the aggregate.

Journal Article Behav Anal · 2000 To evaluate progress and focus goals, scientific disciplines need to identify relations that are robust across many situations. One approach is the literature review, which characterizes generality across studies. Some writers (e.g., Baron & Derenne, 2000) ... Full text Link to item Cite

Effects of training dose on the relationship between discriminative-stimulus and self-reported drug effects of d-amphetamine in humans.

Journal Article Pharmacol Biochem Behav · October 1999 The aim of the present experiment was to examine the relationship between the discriminative-stimulus and self-reported effects of drugs in humans. To accomplish this aim, nine healthy adult volunteers (four females, five males) were trained to discriminat ... Full text Link to item Cite

Factors affecting the reliability of clinical judgments about the function of children's school-refusal behavior.

Journal Article J Clin Child Psychol · September 1999 Conducted two studies to examine the interrater reliability, test-retest stability, and the effect of various clinician variables, such as years of clinical experience, theoretical orientation, and prior experience with children, on clinical judgments abou ... Full text Link to item Cite

Has behavior therapy drifted from its experimental roots? A survey of publication trends in mainstream behavioral journals.

Journal Article J Behav Ther Exp Psychiatry · September 1999 In recent years it has been suggested that behavior therapy, characterized in part by single-subject designs and an idiographic approach to addressing practical problems, is drifting from its experimental roots. To examine trends in behavior therapy, and t ... Full text Link to item Cite

Quantitative integration of single-subject studies: Methods and misinterpretations.

Journal Article Behav Anal · 1999 Derenne and Baron (1999) criticized a quantitative literature review by Kollins, Newland, and Critchfield (1997) and raised several important issues with respect to the integration of single-subject data. In their criticism they argued that the quantitativ ... Full text Link to item Cite

Behavioural assessment of children and adolescents.

Journal Article Indian J Pediatr · 1999 This article is an overview for pediatricians who conduct behavioural assessments of children and adolescents. It identifies the most common behavioural problems encountered by pediatricians and brief descriptions of selected tests that are administered by ... Full text Link to item Cite

Discriminative and participant-rated effects of methylphenidate in children diagnosed with attention deficit hyperactivity disorder (ADHD).

Journal Article Exp Clin Psychopharmacol · November 1998 Despite the demonstrated beneficial effects of methylphenidate and d-amphetamine for the treatment of attention-deficit hyperactivity disorder (ADHD), the discriminative and subjective effects of these compounds in children are not well understood. This st ... Full text Link to item Cite

Comparison of acute behavioral effects of sustained-release and immediate-release methylphenidate.

Journal Article Exp Clin Psychopharmacol · November 1998 The rate of onset of a drug's effect is an important determinant of its abuse potential. This experiment examined the acute behavioral effects of orally administered sustained-release methylphenidate (SR; 20-40 mg), immediate-release methylphenidate (IR; 2 ... Full text Link to item Cite

Discriminative-stimulus and participant-rated effects of methylphenidate, bupropion, and triazolam in d-amphetamine-trained humans.

Journal Article Exp Clin Psychopharmacol · February 1998 The discriminative-stimulus and participate-rated effects of a range of doses of d-amphetamine (2.5-20 mg), methylphenidate (5-40 mg), bupropion (50-400 mg), and triazolam (0.0625-0.5 mg) were tested in 5 humans trained to discriminate between oral d-amphe ... Full text Link to item Cite

Human sensitivity to reinforcement in operant choice: How much do consequences matter?

Journal Article Psychon Bull Rev · June 1997 The results of many human operant conditioning experiments appear to show that humans are less sensitive than nonhumans to operant consequences, suggesting species discontinuities in basic behavioral processes. A reanalysis of 31l data sets from 25 studies ... Full text Link to item Cite

Experimental analysis of childhood psychopathology: A laboratory matching analysis of the behavior of children diagnosed with Attention-Deficit Hyperactivity Disorder (ADHD)

Journal Article Psychological Record · January 1, 1997 The behavior of children diagnosed with Attention-Deficit Hyperactivity Disorder (ADHD) has been hypothesized to involve differential sensitivity to parameters of reward and punishment. However, support for these theories has been limited because, in part, ... Full text Cite