Scholars@Duke
Marat Fudim

Marat Fudim

Associate Professor of Medicine
Medicine, Cardiology

Selected Publications

Meta-Analysis of Renal Denervation Therapy During Pulmonary Vein Isolation in Atrial Fibrillation.

Journal Article Am J Cardiol · November 8, 2024 Pulmonary vein isolation (PVI) has been established as a first-line therapy for symptomatic atrial fibrillation (AF) in selected patients with symptomatic AF and in those whose antiarrhythmic drug treatment failed. However, AF recurrence rates after PVI re ... Full text Link to item Cite

Invasive haemodynamic assessment in heart failure with preserved ejection fraction.

Journal Article ESC Heart Fail · November 8, 2024 Despite the increasing prevalence and substantial burden of heart failure with preserved ejection fraction (HFpEF), which constitutes up to 50% of all heart failure cases, significant challenges persist in its diagnostic and therapeutic strategies. These d ... Full text Link to item Cite

Remote Follow-up in a Heart Failure Pragmatic Trial: Insights From the CONNECT-HF.

Journal Article J Card Fail · November 2024 BACKGROUND: Randomized controlled trials typically require study-specific visits, which can burden participants and sites. Remote follow-up, such as centralized call centers for participant-reported or site-reported, holds promise for reducing costs and en ... Full text Link to item Cite

The impact of atrial fibrillation on clinical outcomes in heart failure with mid-range and preserved ejection fraction patients.

Journal Article Heart Rhythm · November 2024 BACKGROUND: The combined effect of left ventricular ejection fraction (LVEF) and atrial fibrillation (AF) on clinical outcomes in heart failure (HF) remains complex. OBJECTIVE: In this post hoc analysis of the TOPCAT trial, we aimed to evaluate the impact ... Full text Link to item Cite

Ongoing and future clinical trials of device therapies for patients with heart failure.

Journal Article Curr Probl Cardiol · November 2024 Heart failure continues to pose a significant burden in terms of morbidity, mortality, and healthcare costs worldwide despite the implementation of guideline-directed medical therapy. Addressing this challenge and improving clinical outcomes for this patie ... Full text Link to item Cite

HFSA Scientific Statement: Update on Device Based Therapies in Heart Failure.

Journal Article J Card Fail · November 2024 Heart failure (HF) is 1 of the major challenges of our time, given its increase in prevalence and related mortality rates. Foundational pharmacological therapies, including angiotensin receptor neprilysin inhibitors (ARNIs), beta-blockers, mineralocorticoi ... Full text Link to item Cite

Trends and Disparities in Coronary Artery Disease and Obesity-Related Mortality in the United States From 1999-2022.

Journal Article Endocrinol Diabetes Metab · November 2024 BACKGROUND: Almost half of the US adult population has obesity, which predisposes to atherosclerosis and can lead to poor prognosis in coronary artery disease (CAD). We aim to identify CAD and obesity-related mortality trends among adults in the United Sta ... Full text Link to item Cite

The road to renal denervation for hypertension and beyond (HF): two decades of failed, succeeded, and to be determined.

Journal Article Heart failure reviews · November 2024 Activation of the sympathetic nervous system has been attributed to the development of hypertension. Two established approaches for treating hypertension are pharmacotherapy and lifestyle changes. With an improved understanding of renal nerve anatomy and p ... Full text Cite

Discrepancy in the Diagnosis of Heart Failure With Preserved Ejection Fraction Between Supine Versus Upright Exercise Hemodynamic Testing.

Journal Article Circulation. Heart failure · November 2024 BackgroundInvasive exercise right heart catheterization is a gold standard in diagnosing heart failure with preserved ejection fraction (HFpEF). Body positions during the test influence hemodynamics. However, the discrepancy in HFpEF diagnosis bet ... Full text Cite

Harnessing the lymphatic system.

Journal Article Heart Fail Rev · October 15, 2024 Heart failure (HF) is a growing concern, with significant implications for mortality, morbidity, and economic sustainability. Traditionally viewed primarily as a hemodynamic disorder, recent insights have redefined HF as a complex systemic syndrome, emphas ... Full text Link to item Cite

Machine learning in the prevention of heart failure.

Journal Article Heart Fail Rev · October 7, 2024 Heart failure (HF) is a global pandemic with a growing prevalence and is a growing burden on the healthcare system. Machine learning (ML) has the potential to revolutionize medicine and can be applied in many different forms to aid in the prevention of sym ... Full text Link to item Cite

Endovascular Ablation of the Greater Splanchnic Nerve in Heart Failure With Preserved Ejection Fraction: The REBALANCE-HF Randomized Clinical Trial.

Journal Article JAMA Cardiol · October 2, 2024 IMPORTANCE: Greater splanchnic nerve ablation may improve hemodynamics in patients with heart failure and preserved ejection fraction (HFpEF). OBJECTIVE: To explore the feasibility and safety of endovascular right-sided splanchnic nerve ablation for volume ... Full text Link to item Cite

Spot urine sodium-to-creatinine ratio surpasses sodium in identifying poor diuretic response in acute heart failure.

Journal Article ESC Heart Fail · October 2024 AIMS: We aim to identify the most accurate marker for early prediction of poor diuretic response in acute heart failure (AHF) patients with signs of congestion requiring intravenous diuretic treatment. METHODS: In this single-centre, prospective observatio ... Full text Link to item Cite

Diastolic dysfunction in hypertension: a comprehensive review of pathophysiology, diagnosis, and treatment.

Journal Article European heart journal. Cardiovascular Imaging · October 2024 Diastolic dysfunction refers to impaired relaxation or filling of the ventricles during the diastolic phase of the cardiac cycle. Left ventricular diastolic dysfunction (LVDD) is common in hypertensive individuals and is associated with increased morbidity ... Full text Cite

Atrial Mechanics, Atrial Cardiomyopathy and Impact of Atrial Interventions.

Journal Article J Card Fail · October 2024 Our comprehension of atrial mechanics, atrial cardiomyopathy and their clinical implications across various cardiovascular conditions has advanced significantly. Atrial interventions can have differing effects on atrial mechanics. With the rapid increase i ... Full text Link to item Cite

Safety and Feasibility of an Implanted Inferior Vena Cava Sensor for Accurate Volume Assessment: FUTURE-HF2 Trial.

Journal Article J Card Fail · September 28, 2024 BACKGROUND: A novel implantable sensor has been designed to measure the inferior vena cava (IVC) area accurately so as to allow daily monitoring of the IVC area and collapse to predict congestion in heart failure (HF). METHODS: A prospective, multicenter, ... Full text Link to item Cite

Baroreflex Function in Cardiovascular Disease.

Journal Article J Card Fail · September 27, 2024 The baroreflex system is involved in modulating several physiological functions of the cardiovascular system and can modulate cardiac output, blood pressure, and cardiac electrophysiology directly and indirectly. In addition, it is involved in regulating n ... Full text Link to item Cite

Surveillance and Alert-based Multiparameter Monitoring to Reduce Worsening Heart Failure Events: Results From SCALE-HF 1.

Journal Article J Card Fail · September 17, 2024 BACKGROUND: There is a need for better noninvasive remote monitoring solutions that prevent hospitalizations through the early prediction and management of heart failure (HF). SurveillanCe and Alert-Based Multiparameter Monitoring to ReducE Worsening Heart ... Full text Link to item Cite

The Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure with Preserved Ejection Fraction (SPIRRIT-HFpEF): Rationale and design.

Journal Article Eur J Heart Fail · September 16, 2024 AIMS: Benefits of mineralocorticoid receptor antagonists (MRAs) in heart failure with preserved and mildly reduced ejection fraction (HFpEF/HFmrEF) have not been established. Conventional randomized controlled trials are complex and expensive. The Spironol ... Full text Link to item Cite

Understanding the variability in red cell and plasma volume combinations can help guide management in heart failure.

Journal Article ESC Heart Fail · September 12, 2024 AIMS: Quantitative methods have shown clinically significant heterogeneity in blood volume (BV) profiles across heart failure (HF) phenotypes. These profiles extend from hypovolaemia to normal BV and to variable degrees of BV hypervolaemia, frequently with ... Full text Link to item Cite

Factors associated with stellate ganglion block success in recurrent ventricular arrhythmias.

Journal Article ESC Heart Fail · September 10, 2024 AIMS: One treatment option for refractory ventricular arrythmias is stellate ganglion block (SGB). We examined differences in SGB success by patient and arrhythmia characteristics and predictors of successful SGB. METHODS AND RESULTS: This was a multicente ... Full text Link to item Cite

The Pandemic That Never Left.

Journal Article J Card Fail · September 2024 Full text Link to item Cite

Association of disproportionate liver fat with markers of heart failure: The multi-ethnic study of atherosclerosis.

Journal Article Am Heart J · September 2024 BACKGROUND: Metabolic dysfunction associated steatotic liver disease (MASLD) has been linked to heart failure with preserved ejection fraction (HFpEF). We sought to understand association between individuals with amounts of liver adiposity greater than wou ... Full text Link to item Cite

Non-invasive heart failure monitoring: leveraging smart scales and digital biomarkers to improve heart failure outcomes.

Journal Article Heart Fail Rev · September 2024 Heart failure (HF) is a significant global concern, impacting patient morbidity, mortality, and healthcare costs. Guideline-directed medical therapy and various preventive measures have proven effective in improving clinical outcomes and reducing HF hospit ... Full text Link to item Cite

Device therapy for heart failure management.

Journal Article Curr Opin Cardiol · September 1, 2024 PURPOSE OF REVIEW: Given the prevalence of heart failure (HF) and the interdisciplinary nature of device therapy, it is paramount that cardiologists not only understand the current landscape of goal-directed medical therapy, but also the ongoing efforts in ... Full text Link to item Cite

Inpatient Use of Guideline-Directed Medical Therapy During Heart Failure Hospitalizations Among Community-Based Health Systems.

Journal Article JACC Heart Fail · August 30, 2024 BACKGROUND: Guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF) remains underused. Acute heart failure (HF) hospitalization represents a critical opportunity for rapid initiation of evidence-based medications. ... Full text Link to item Cite

Digital Health: From Remote Monitoring to Remote Care.

Journal Article J Card Fail · August 20, 2024 The growth of digital health technology has led to innovative technological solutions that can help to improve patient care. However, the primary focus to date has been on the passive monitoring of patients, which poses difficulties in clinical integration ... Full text Link to item Cite

Left Ventricular Unloading Using Intra-aortic Entrainment Pumping Before Reperfusion Reduces Post-AMI Infarct Size.

Journal Article J Card Fail · August 13, 2024 BACKGROUND: Anterior myocardial infarction standard of care prioritizes swift coronary reperfusion. Recent studies show left ventricular (LV) unloading with transvalvular axial flow pumps for 30 minutes before reperfusion (vs immediate reperfusion) decreas ... Full text Link to item Cite

Outcomes of Cardiac Resynchronization Therapy by New York Heart Association Class: A Patient-Level Meta-Analysis.

Journal Article J Am Heart Assoc · August 6, 2024 BACKGROUND: Data on the benefits of cardiac resynchronization therapy (CRT) in patients with severe heart failure symptoms are limited. We investigated the relative effects of CRT in patients with ambulatory New York Heart Association (NYHA) IV versus III ... Full text Link to item Cite

Prognostic value of quality of life and functional status in patients with heart failure: a systematic review and meta-analysis.

Journal Article Egypt Heart J · August 5, 2024 BACKGROUND: Functional health status is increasingly being recognized as a viable endpoint in heart failure (HF) trials. We sought to assess its prognostic impact and relationship with traditional clinical outcomes in patients with HF. METHODS: MEDLINE and ... Full text Link to item Cite

Contemporary Decongestion Strategies in Patients Hospitalized for Heart Failure: A National Community-Based Cohort Study.

Journal Article JACC Heart Fail · August 2024 BACKGROUND: Heart failure (HF) is a leading cause of hospitalization in the United States. Decongestion remains a central goal of inpatient management, but contemporary decongestion practices and associated weight loss have not been well characterized nati ... Full text Link to item Cite

Has mortality in the United States returned to pre-pandemic levels? An analysis of provisional 2023 data.

Journal Article J Intern Med · August 2024 BACKGROUND: The COVID-19 pandemic, which started in 2020, resulted in greater all-cause mortality in 2020 and in subsequent years. Whether all-cause mortality remains elevated in 2023 compared to pre-pandemic numbers is unknown. METHODS AND RESULTS: The Un ... Full text Link to item Cite

Feasibility of a Novel Augmented 6-Minute Incremental Step Test: A Simplified Cardiorespiratory Fitness Assessment Tool.

Journal Article JACC Adv · August 2024 BACKGROUND: The cardiopulmonary exercise test (CPET) is considered a gold standard in assessing cardiorespiratory fitness (CRF) but has limited accessibility due to competency requirements and cost. Incorporating portable sensor devices into a simple bedsi ... Full text Link to item Cite

Interleukin-6 and Cardiovascular Events in Healthy Adults: MESA.

Journal Article JACC Adv · August 2024 BACKGROUND: Elevated interleukin (IL)-6 levels have been linked to adverse outcomes in patients with and without baseline cardiovascular disease (CVD). OBJECTIVES: The purpose of this study was to examine the association between circulating IL-6 levels and ... Full text Link to item Cite

Characterizing atrial fibrillation in patients with and without heart failure across the ejection fraction spectrum: Incidence, prevalence, and treatment strategies.

Journal Article Eur J Heart Fail · August 1, 2024 AIMS: Heart failure (HF) and atrial fibrillation (AF) often coexist. We explored AF incidence, prevalence, and treatment strategies in patients with versus without HF across the ejection fraction (EF) spectrum. METHODS AND RESULTS: We analysed patients wit ... Full text Link to item Cite

Intravenous iron therapy for heart failure and iron deficiency: An updated meta-analysis of randomized clinical trials.

Journal Article ESC Heart Fail · July 4, 2024 Heart failure (HF) patients frequently exhibit iron deficiency, which is associated with a poor prognosis. Although various trials have been conducted, it is uncertain if intravenous (IV) iron replenishment improves clinical outcomes in HF patients with ir ... Full text Link to item Cite

Endovascular Ablation of the Right Greater Splanchnic Nerve in Heart Failure With Preserved Ejection Fraction: Rationale, Design and Lead-in Phase Results of the REBALANCE-HF Trial.

Journal Article J Card Fail · July 2024 OBJECTIVE: Splanchnic vasoconstriction augments transfer of blood volume from the abdomen into the thorax, which may increase filling pressures and hemodynamic congestion in patients with noncompliant hearts. Therapeutic interruption of splanchnic nerve ac ... Full text Link to item Cite

Blood Pressure Response and Symptoms During Active Standing Test Among Hospitalized and Outpatients With Heart Failure: Results From the GRAVITY-HF Prospective Observational Cohort Study.

Journal Article J Card Fail · July 2024 BACKGROUND: We conducted a multicenter, prospective, observational study to describe the incidence of orthostatic hypotension (OH) and orthostatic hypertension (OHtn) and its association with symptoms at standing and outcomes in patients with heart failure ... Full text Link to item Cite

Prevalence and Predictors of Readmissions in Patients With Hypertrophic Cardiomyopathy and Atrial Fibrillation/Flutter.

Journal Article Am J Cardiol · July 1, 2024 Atrial fibrillation/flutter (AF) is the most common dysrhythmia in patients with hypertrophic cardiomyopathy (HCM). Unexplained left ventricular hypertrophy and left ventricular outflow tract obstruction are integral components of HCM pathology which can c ... Full text Link to item Cite

Association between atrial fibrillation and heart failure patient reported outcomes across the ejection fraction spectrum.

Journal Article Am Heart J · July 2024 BACKGROUND: Atrial fibrillation (AF) is common in patients with heart failure (HF) and is associated with worse clinical outcomes. We evaluated the relationship between AF and longitudinal changes in health-related quality of life (HRQoL) measured by Kansa ... Full text Link to item Cite

Lower Extremity Lymphatic Flow/Drainage Assessment by Indocyanine Green Fluorescent Lymphography in Heart Failure Patients.

Journal Article JACC Basic Transl Sci · July 2024 The purpose of this study was to present a protocol for visualizing lymphatic flow in patients with heart failure (HF) by using indocyanine green fluorescence lymphography. We studied 37 subjects: 20 patients with acute heart failure (AHF) and lower limb e ... Full text Link to item Cite

Ongoing and Future Clinical Trials of Pharmacotherapy for Heart Failure.

Journal Article Am J Cardiovasc Drugs · July 2024 Increasing knowledge of the processes leading to heart failure (HF) has allowed significant developments in therapies for HF over the past few decades. Despite the evolution of HF treatment, it still places a large burden on patients and health care system ... Full text Link to item Cite

Ultrasound Neuromodulation of an Anti-Inflammatory Pathway at the Spleen Improves Experimental Pulmonary Hypertension.

Journal Article Circ Res · June 21, 2024 BACKGROUND: Inflammation is pathogenically implicated in pulmonary arterial hypertension; however, it has not been adequately targeted therapeutically. We investigated whether neuromodulation of an anti-inflammatory neuroimmune pathway involving the spleni ... Full text Link to item Cite

The role of urine chloride in acute heart failure.

Journal Article Sci Rep · June 18, 2024 In our retrospective study, we aimed to investigate the relationship between urinary chloride (uCl-) and selected clinical and laboratory biomarkers, renal function, and patient outcomes in the acute heart failure (AHF) population. We divided 248 adult pat ... Full text Link to item Cite

Patient Sex Impacts Volume Phenotypes and Hemodynamics in Chronic Heart Failure: A Multicenter Analysis.

Journal Article J Card Fail · June 14, 2024 BACKGROUND: Quantitative methods have shown clinically significant heterogeneity in blood volume (BV) profiles in patients with chronic heart failure (HF). How patients' sex might impact this volume heterogeneity and its relationship to cardiac hemodynamic ... Full text Link to item Cite

Racial and ethnic disparities in cardiovascular disease - analysis across major US national databases.

Journal Article J Natl Med Assoc · June 2024 BACKGROUND: There are several studies that have analyzed disparities in cardiovascular disease (CVD) health using a variety of different administrative databases; however, a unified analysis of major databases does not exist. In this analysis of multiple p ... Full text Link to item Cite

Relationship between sex, body size, and cardiac resynchronization therapy benefit: A patient-level meta-analysis of randomized controlled trials.

Journal Article Heart Rhythm · June 2024 BACKGROUND: Women might benefit more than men from cardiac resynchronization therapy (CRT) and do so at shorter QRS durations. OBJECTIVE: This meta-analysis was performed to determine whether sex-based differences in CRT effects are better accounted for by ... Full text Link to item Cite

Role of telemedicine in the management of obesity: State-of-the-art review.

Journal Article Obes Rev · June 2024 Obesity is a worsening public health epidemic that remains challenging to manage. Obesity substantially increases the risk of cardiovascular diseases and presents a significant financial burden on the healthcare system. Digital health interventions, specif ... Full text Link to item Cite

Effects of Sacubitril/Valsartan vs Valsartan in De Novo vs Acute on Chronic HFpEF and HFmrEF.

Journal Article JACC Adv · June 2024 BACKGROUND: Decompensated heart failure (HF) can be categorized as de novo or worsening of chronic HF. In PARAGLIDE-HF (Prospective comparison of ARNI with ARB Given following stabiLization In DEcompensated HFpEF), among patients with an ejection fraction  ... Full text Link to item Cite

The Tricuspid Valve: A Review of Pathology, Imaging, and Current Treatment Options: A Scientific Statement From the American Heart Association.

Journal Article Circulation · May 28, 2024 Tricuspid valve disease is an often underrecognized clinical problem that is associated with significant morbidity and mortality. Unfortunately, patients will often present late in their disease course with severe right-sided heart failure, pulmonary hyper ... Full text Link to item Cite

Association of Sacubitril/Valsartan vs Valsartan With Blood Pressure Changes and Symptomatic Hypotension: the PARAGLIDE-HF Trial.

Journal Article J Card Fail · May 26, 2024 BACKGROUND: In PARAGLIDE-HF, in patients with ejection fraction (EF) > 40%, stabilized after worsening heart failure (WHF), sacubitril/valsartan led to greater reduction in plasma NT-proBNP levels and was associated with clinical benefit compared to valsar ... Full text Link to item Cite

Role of splanchnic circulation in the pathogenesis of heart failure: State-of-the-art review.

Journal Article J Cardiol · May 2024 A hallmark of heart failure (HF), whether it presents itself during rest or periods of physical exertion, is the excessive elevation of intracardiac filling pressures at rest or with exercise. Many mechanisms contribute to the elevated intracardiac filling ... Full text Link to item Cite

Previous heart failure hospitalization, spironolactone, and outcomes in heart failure with preserved ejection fraction - a secondary analysis of TOPCAT.

Journal Article Am Heart J · May 2024 BACKGROUND: Hospitalization for heart failure (HHF) is associated with poor postdischarge outcomes but the role of time since most recent HHF and potential treatment interactions are unknown. We aimed to assess history of and time since previous HHF, assoc ... Full text Link to item Cite

Prognostic implications of volume status assessed by blood volume analysis in ambulatory heart failure.

Journal Article Am Heart J · May 2024 The prognostic implications of intravascular volume status assessed by blood volume analysis (BVA) in ambulatory heart failure (HF) remain uncertain. The incremental benefits of assessing volume status, beyond the well-established filling pressures, in pre ... Full text Link to item Cite

The early safety profile of simultaneous vaccination against influenza and Respiratory Syncytial Virus (RSV) in patients with high-risk heart failure.

Journal Article Vaccine · April 30, 2024 The safety of simultaneous vaccination for Respiratory Syncytial Virus (RSV) and influenza in vulnerable high-risk heart failure (HF) patients remains unclear. In an open-label, prospective study, 105 patients received concurrent influenza (Vaxigrip Tetra, ... Full text Link to item Cite

Empagliflozin in the treatment of heart failure.

Journal Article Future Cardiol · April 25, 2024 Heart failure (HF) affects more than 60 million individuals globally. Empagliflozin is currently approved for type 2 diabetes and chronic HF. Clinical trials have demonstrated that empagliflozin reduces the composite end point of hospitalizations for HF an ... Full text Link to item Cite

Comorbidities and clinical response to cardiac resynchronization therapy: Patient-level meta-analysis from eight clinical trials.

Journal Article Eur J Heart Fail · April 2024 AIMS: Patients with heart failure usually have several other medical conditions that might alter the effects of interventions. We investigated whether the burden of comorbidity modified the clinical response to cardiac resynchronization therapy (CRT). METH ... Full text Link to item Cite

A Multicenter Study of Stellate Ganglion Block as a Temporizing Treatment for Refractory Ventricular Arrhythmias.

Journal Article JACC Clin Electrophysiol · April 2024 BACKGROUND: Ventricular tachycardia (VT) and ventricular fibrillation (VF) are life-threatening conditions and can be refractory to conventional drug and device interventions. Stellate ganglion blockade (SGB) has been described as an adjunct, temporizing i ... Full text Link to item Cite

Acetazolamide as an Adjunctive Diuretic Therapy for Patients with Acute Decompensated Heart Failure: A Systematic Review and Meta-Analysis.

Journal Article Am J Cardiovasc Drugs · March 2024 BACKGROUND: Recent evidence suggests that acetazolamide may be beneficial as an adjunctive diuretic therapy in patients with acute decompensated heart failure (HF). We aim to pool all the studies conducted until now and provide updated evidence regarding t ... Full text Link to item Cite

Cognitive Impairment in Heart Failure: A Heart Failure Society of America Scientific Statement.

Journal Article J Card Fail · March 2024 Cognitive impairment is common among adults with heart failure (HF), as both diseases are strongly related to advancing age and multimorbidity (including both cardiovascular and noncardiovascular conditions). Moreover, HF itself can contribute to alteratio ... Full text Link to item Cite

Intrarenal Venous Flow Pattern Changes Do Relate With Renal Function Alterations in Acute Heart Failure.

Journal Article JACC Heart Fail · February 2024 BACKGROUND: There is scarce evidence supporting the clinical utility of congestive intrarenal venous flow (IRVF) patterns in patients with acute heart failure. OBJECTIVES: This study aims to: 1) investigate the association between IRVF patterns and the odd ... Full text Link to item Cite

Use of invasive cardiopulmonary exercise testing to diagnose preload reserve failure in patients with liver disease.

Journal Article ESC Heart Fail · February 2024 In this case series, we describe the use of invasive cardiopulmonary exercise testing (iCPET) to diagnose heart failure due to preload reserve failure in two patients with progressive dyspnoea. We demonstrate that underlying liver disease contributes to pr ... Full text Link to item Cite

Novel Trial Designs in Heart Failure: Using Digital Health Tools to Increase Pragmatism.

Journal Article Curr Heart Fail Rep · February 2024 PURPOSE OF REVIEW: Heart failure is an important clinical and public health issue. There is an urgent need to improve the efficiency of clinical trials in heart failure to rapidly identify new therapies and evidence-based implementation strategies for curr ... Full text Link to item Cite

Neuromodulation interventions in the management of heart failure.

Journal Article Eur J Heart Fail · February 2024 Despite remarkable improvements in the management of heart failure (HF), HF remains one of the most rapidly growing cardiovascular condition resulting in a substantial burden on healthcare systems worldwide. In clinical practice, however, a relevant propor ... Full text Link to item Cite

A pilot study of longitudinal changes in neurocognition, white matter hyperintensities, and cortical thickness in atrial fibrillation patients following catheter ablation vs medical management.

Journal Article Heart Rhythm O2 · February 2024 BACKGROUND: Cerebral microembolization and atrophy complicate atrial fibrillation (AF). OBJECTIVES: We aimed to compare changes in neuroimaging findings between AF patients treated with catheter ablation and those treated with medical therapy. METHODS: In ... Full text Link to item Cite

Spot urine sodium as a marker of urine dilution and decongestive abilities in acute heart failure.

Journal Article Sci Rep · January 17, 2024 The decongestion ability in response to diuretic treatment plays a crucial role in the treatment of acute heart failure. This effectiveness is evaluated through the assessment of sodium concentration and urine volume, which are also treatment goals themsel ... Full text Link to item Cite

Interatrial Shunt Devices.

Journal Article Heart Fail Clin · January 2024 Elevated left atrial pressure during exercise is a hallmark of heart failure (HF) and is associated with adverse left atrial remodeling and poor outcomes. To decompress the pressure-overloaded left atrium in patients with HF, several device-based approache ... Full text Link to item Cite

Preload Reduction Therapies in Heart Failure.

Journal Article Heart Fail Clin · January 2024 Preload reserve represents an important concept in the normal physiologic responses of the body to meet the changing metabolic demands. The recruitment of preload in healthy patients leads to an increase in effective circulating blood volume with a concomi ... Full text Link to item Cite

The spectrum of post-myocardial infarction care: From acute ischemia to heart failure.

Journal Article Prog Cardiovasc Dis · 2024 Heart failure (HF) is the leading cause of mortality in patients with acute myocardial infarction (AMI), with incidence ranging from 14% to 36% in patients admitted due to AMI. HF post-MI develops due to complex inter-play between macrovascular obstruction ... Full text Link to item Cite

Emerging devices for heart failure management.

Journal Article Prog Cardiovasc Dis · 2024 There have been significant advances in the treatment of heart failure (HF) in recent years, driven by significant strides in guideline-directed medical therapy (GDMT). Despite this, HF is still associated with high levels of morbidity and mortality, and m ... Full text Link to item Cite

Brief report: Effect of cardiac multi-morbidity on COVID hospitalization outcomes.

Journal Article PLoS One · 2024 BACKGROUND: The COVID-19 pandemic has stretched healthcare resources thin and led to significant morbidity and mortality. There have been no studies utilizing national data to investigate the role of cardiac risk factors on outcomes of COVID hospitalizatio ... Full text Link to item Cite

Metabolic and Pharmacokinetic Profiling of a Ketone Ester by Background SGLT2 Inhibitor Therapy in HFrEF

Journal Article JACC: Basic to Translational Science · January 1, 2024 Growing evidence supports therapeutic ketosis in heart failure with reduced ejection fraction, though uncertainty exists regarding use with SGLT2i and dose-dependent effects. In a phase I trial of 2 ketone ester (KE) doses in 20 heart failure with reduced ... Full text Cite

Relationship of Vascular Endothelial Growth Factor C, a Lymphangiogenesis Modulator, With Edema Formation, Congestion and Outcomes in Acute Heart Failure.

Journal Article J Card Fail · December 2023 BACKGROUND: Although vascular endothelial growth factor C (VEGF-C) is a known lymphangiogenesis modulator, its relationship with congestion formation and outcomes in acute heart failure (AHF) is unknown. METHODS: Serum VEGF-C levels were measured in 237 pa ... Full text Link to item Cite

Prospective association of occupational and leisure-time physical activity with orthostatic blood pressure changes in older adults.

Journal Article Sci Rep · November 24, 2023 Orthostatic hypotension (OH) is common in older people. We examined the influence of self-reported occupational-related physical activity (PA) and leisure-time physical exercise (PE) on orthostatic response in a sample of older people over a 2 year period. ... Full text Link to item Cite

Safety and Efficacy of Renal Denervation in Patients Taking Antihypertensive Medications.

Journal Article J Am Coll Cardiol · November 7, 2023 BACKGROUND: Renal denervation (RDN) reduces blood pressure (BP) in patients with uncontrolled hypertension in the absence of antihypertensive medications. OBJECTIVES: This trial assessed the safety and efficacy of RDN in the presence of antihypertensive me ... Full text Link to item Cite

Translating Pressure Into Practice: Operational Characteristics of Ambulatory Hemodynamic Monitoring Program in the United States.

Journal Article J Card Fail · November 2023 BACKGROUND: Ambulatory hemodynamic monitoring (AHM) using an implantable pulmonary artery pressure sensor (CardioMEMS) is effective in improving outcomes for patients with heart failure. The operations of AHM programs are crucial to clinical efficacy of AH ... Full text Link to item Cite

Association of Hospital Procedural Volume With Outcomes of Left Ventricular Assist Device Placement.

Journal Article J Card Fail · November 2023 BACKGROUND: With the advancement in device technology, the use of durable left ventricular assist devices (LVADs) has increased significantly in recent years. However, there is a dearth of evidence to conclude whether patients who undergo LVAD implantation ... Full text Link to item Cite

Socioeconomic status and in-hospital outcomes for patients undergoing heart transplantation or ventricular assist device implantation.

Journal Article Clin Transplant · November 2023 INTRODUCTION: Although lower socioeconomic status (SES) has been associated with worse in-hospital outcomes among patients with heart failure, the in-hospital outcomes for patients undergoing durable Left Ventricular Assist Device (LVAD) implantation or He ... Full text Link to item Cite

Shedding Light on Latent Pulmonary Vascular Disease in Heart Failure With Preserved Ejection Fraction.

Journal Article JACC Heart Fail · October 2023 BACKGROUND: Among patients with heart failure with preserved ejection fraction (HFpEF), a distinct hemodynamic phenotype has been recently described, ie, latent pulmonary vascular disease (HFpEF-latentPVD), defined by exercise pulmonary vascular resistance ... Full text Link to item Cite

Frailty and heart failure: State-of-the-art review.

Journal Article J Cachexia Sarcopenia Muscle · October 2023 At least half of all patients with heart failure (HF) are affected by frailty, a syndrome that limits an individual ability to recover from acute stressors. While frailty affects up to 90% of patients with HF with preserved ejection fraction, it is also se ... Full text Link to item Cite

Kidney function changes in acute heart failure: a practical approach to interpretation and management.

Journal Article Clin Kidney J · October 2023 Worsening kidney function (WKF) is common in patients with acute heart failure (AHF) syndromes. Although WKF has traditionally been associated with worse outcomes on a population level, serum creatinine concentrations vary greatly during episodes of worsen ... Full text Link to item Cite

Heart Failure Remote Monitoring: A Review and Implementation How-To.

Journal Article J Clin Med · September 26, 2023 Heart failure (HF) is a significant clinical and financial burden worldwide. Remote monitoring (RM) devices capable of identifying early physiologic changes in decompensation have the potential to reduce the HF burden. However, few trials have discussed at ... Full text Link to item Cite

Stressed Blood Volume in Severe Tricuspid Regurgitation: Implications for Transcatheter Treatment.

Journal Article JACC Cardiovasc Interv · September 25, 2023 BACKGROUND: Although tricuspid transcatheter edge-to-edge repair (TEER) has been suggested to improve outcomes in patients with tricuspid regurgitation (TR), patients remain at substantial residual risk after the intervention. Total blood volume is divided ... Full text Link to item Cite

Decoupling of Hemodynamics and Congestive Symptoms in Obese Patients With Heart Failure.

Journal Article J Card Fail · September 2023 BACKGROUND: Prior studies indicate significant physiological differences between obese and nonobese patients with heart failure (HF), but none have evaluated differences in hemodynamic patterns in these patient populations during treatment for acute decomp ... Full text Link to item Cite

Effects of COVID-19 on heart failure admissions.

Journal Article American heart journal · September 2023 Despite significant investigation into the effects of COVID-19 on cardiovascular disease, there is a paucity of national data specifically examining its effects on heart failure (HF) hospitalizations. Previous cohort study data demonstrate worsened outcome ... Full text Cite

Why Do Exercise Hemodynamics Matter?

Journal Article J Card Fail · September 2023 Full text Link to item Cite

Association of Chronic Renal Insufficiency with Inhospital Outcomes in Primary Heart Failure Hospitalizations (Insights from the National Inpatient Sample 2004 to 2018).

Journal Article Am J Cardiol · September 1, 2023 Chronic kidney disease (CKD) is a major co-morbidity in patients with heart failure (HF). There are limited contemporary data characterizing the clinical profile, inhospital outcomes, and resource use in patients hospitalized for HF with co-morbid CKD. We ... Full text Link to item Cite

Sodium-glucose cotransporter-2 inhibitors in heart failure: Potential decongestive mechanisms and current clinical studies.

Journal Article Eur J Heart Fail · September 2023 Congestion is a key pathophysiological feature of heart failure (HF) syndrome that drives most of the clinical manifestations of acute HF and is related with poor quality of life and outcomes. Therefore, safe and effective decongestion is an important ther ... Full text Link to item Cite

Cardiac resynchronization therapy in patients with a prior history of atrial fibrillation: Insights from four major clinical trials.

Journal Article J Cardiovasc Electrophysiol · September 2023 AIMS: To investigate the association of cardiac resynchronization therapy (CRT) on outcomes among participants with and without a history of atrial fibrillation (AF). METHODS: Individual-patient-data from four randomized trials investigating CRT-Defibrilla ... Full text Link to item Cite

Association of Non-Alcoholic Fatty Liver Disease With in-Hospital Outcomes in Primary Heart Failure Hospitalizations With Reduced or Preserved Ejection Fraction.

Journal Article Curr Probl Cardiol · August 2023 Recent studies focusing on the prevalence, characteristics, and outcomes of primary heart failure (HF) with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF) in non-alcoholic fatty liver disease (NAFLD) are sparse. We sought to asse ... Full text Link to item Cite

Characteristics and outcomes in acute myocardial infarction hospitalizations among the older population (age ≥80 years) in the United States, 2004-2018.

Journal Article Arch Gerontol Geriatr · August 2023 IMPORTANCE: Acute myocardial infarction (AMI) is a major health concern among older adults (≥80 years). We analyzed a US national database to evaluate the clinical outcomes, resource utilization, and economic burden of AMI hospitalizations in older patient ... Full text Link to item Cite

The blunted loop diuretic response in acute heart failure is driven by reduced tubular responsiveness rather than insufficient tubular delivery. The role of furosemide urine excretion on diuretic and natriuretic response in acute heart failure.

Journal Article European journal of heart failure · August 2023 AimsDiuretic response in heart failure is blunted when compared to healthy individuals, but the pathophysiology underlying this phenomenon is unclear. We aimed to investigate whether the diuretic resistance mechanism is related to insufficient fur ... Full text Cite

An international multidisciplinary consensus statement on MAFLD and the risk of CVD.

Journal Article Hepatol Int · August 2023 BACKGROUND: Fatty liver disease in the absence of excessive alcohol consumption is an increasingly common condition with a global prevalence of ~ 25-30% and is also associated with cardiovascular disease (CVD). Since systemic metabolic dysfunction underlie ... Full text Link to item Cite

Pathophysiology and Treatment Opportunities of Iron Deficiency in Heart Failure: Is There a Need for Further Trials?

Journal Article Curr Heart Fail Rep · August 2023 PURPOSE OF REVIEW: Iron deficiency (ID) complicates heart failure (HF) at different stages of the natural history of the disease; however, this frequent comorbidity is still not comprehensively understood and investigated in terms of pathophysiology. Intra ... Full text Link to item Cite

Device Interventions for Heart Failure.

Journal Article JACC Heart Fail · August 2023 Despite remarkable advances in drug therapy for heart failure (HF), the residual HF-related morbidity, mortality, and hospitalizations remain substantial across all HF phenotypes, and significant proportions of patients with HF remain symptomatic despite o ... Full text Link to item Cite

Splanchnic Nerve Modulation Effects on Surrogate Measures of Venous Capacitance.

Journal Article J Am Heart Assoc · July 18, 2023 Background Splanchnic nerve modulation (SNM) is an emerging procedure to reduce cardiac filling pressures in heart failure. Although the main contributor to reduction in cardiac preload is thought to be increased venous capacitance in the splanchnic circul ... Full text Link to item Cite

Serum Metabolites Are Associated With HFpEF in Biopsy-Proven Nonalcoholic Fatty Liver Disease.

Journal Article J Am Heart Assoc · July 18, 2023 Background Nonalcoholic fatty liver disease (NAFLD) and heart failure with preserved ejection fraction (HFpEF) share common risk factors, including obesity and diabetes. They are also thought to be mechanistically linked. The aim of this study was to defin ... Full text Link to item Cite

Outcomes of Cardiac Resynchronization Therapy by New York Heart Association Class: A Patient-Level Meta-Analysis.

Journal Article medRxiv · July 6, 2023 Data on the benefits of cardiac resynchronization therapy (CRT) in patients with severe heart failure (HF) symptoms are limited. We investigated the relative effects of CRT in patients with ambulatory NYHA IV vs. III functional class at the time of device ... Full text Link to item Cite

Has the first year of the COVID-19 pandemic reversed the trends in CV mortality between 1999 and 2019 in the United States?

Journal Article Eur Heart J Qual Care Clin Outcomes · June 21, 2023 AIMS: Although cardiovascular (CV) mortality increased during the COVID-19 pandemic, little is known about how these patterns varied across key subgroups, including age, sex, and race and ethnicity, as well as by specific cause of CV death. METHODS AND RES ... Full text Link to item Cite

Cardiovascular Diseases in the Patients With Psoriatic Arthritis.

Journal Article Curr Probl Cardiol · June 2023 There are limited data regarding the burden and trend of cardiovascular diseases (CVD) in psoriatic arthritis (PsA). We analyzed the National Inpatient Sample database from January 2005 to December 2018 to examine the hospitalization trends amongst adults ... Full text Link to item Cite

Transvenous Endomyocardial Biopsy Technique for Intra-abdominal Heterotopic Cardiac Grafts.

Journal Article J Cardiovasc Transl Res · June 2023 The porcine intra-abdominal heterotopic heart transplantation model allows for the assessment of immunologic effects on cardiac transplantation without relying on the allograft to maintain hemodynamic support for the animal. Historically, allograft functio ... Full text Link to item Cite

Pressure-Volume Profiles in Heart Failure Across Sexes and Phenotypes.

Journal Article J Cardiovasc Transl Res · June 2023 Studies have shown poor correlation between intra-cardiac pressures and blood volume (BV) measurements including HF. The impact of sex and left ventricular ejection fraction (LVEF) on this relationship has not been studied. We obtained pressure (pulmonary ... Full text Link to item Cite

Blood Pressure Variability in Clinical Practice: Past, Present and the Future.

Journal Article J Am Heart Assoc · May 2, 2023 Recent advances in wearable technology through convenient and cuffless systems will enable continuous, noninvasive monitoring of blood pressure (BP), heart rate, and heart rhythm on both longitudinal 24-hour measurement scales and high-frequency beat-to-be ... Full text Link to item Cite

Management of Heart Failure With Reduced Ejection Fraction.

Journal Article Curr Probl Cardiol · May 2023 Heart failure with reduced ejection fraction (HFrEF) is a complex and progressive clinical condition characterized by dyspnea and functional impairment. HFrEF has a high burden of mortality and readmission rate making it one of the most significant public ... Full text Link to item Cite

Safety and performance of a novel implantable sensor in the inferior vena cava under acute and chronic intravascular volume modulation.

Journal Article European journal of heart failure · May 2023 AimsThe management of congestion is one of the key treatment targets in heart failure. Assessing congestion is, however, difficult. The purpose of this study was to investigate the safety and dynamic response of a novel, passive, inferior vena cav ... Full text Cite

Trends and Outcomes in Cardiac Arrest Among Heart Failure Admissions.

Journal Article Am J Cardiol · May 1, 2023 There is limited large, national data investigating the prevalence, characteristics, and outcomes of cardiac arrest (CA) in patients hospitalized for heart failure (HF). The goal of this study was to examine the characteristics, trends, and outcomes of HF ... Full text Link to item Cite

Comparison of sodium-glucose cotransporter-2 inhibitors and thiazolidinediones for management of non-alcoholic fatty liver disease: A systematic review and meta-analysis.

Journal Article Clin Res Hepatol Gastroenterol · May 2023 BACKGROUND: The pharmacologic treatment of non-alcoholic fatty liver disease (NAFLD) remains unclear. METHODS: Two reviewers searched PubMed, SCOPUS, Cochrane Central and clinicaltrials.gov for randomized controlled trials (RCTs) of patients with NAFLD wit ... Full text Link to item Cite

Use of a Cardiac Scale to Predict Heart Failure Events: Design of SCALE-HF 1.

Journal Article Circ Heart Fail · May 2023 BACKGROUND: There is a need for simple, noninvasive solutions to remotely monitor and predict worsening heart failure (HF) events. SCALE-HF 1 (Surveillance and Alert-Based Multiparameter Monitoring to Reduce Worsening Heart Failure Events) is a prospective ... Full text Link to item Cite

Rapid Sequence Initiation of Device Therapy in Heart Failure

Journal Article JACC. Advances · May 2023 Cite

Changes in the Inferior Vena Cava Are More Sensitive Than Venous Pressure During Fluid Removal: A Proof-of-Concept Study.

Journal Article J Card Fail · April 2023 BACKGROUND: Congestion is central to the pathophysiology of heart failure (HF); thus, tracking congestion is crucial for the management of patients with HF. In this study we aimed to compare changes in inferior vena cava diameter (IVCD) with venous pressur ... Full text Link to item Cite

Temporal Trends and Outcomes of Implantable Cardioverter Defibrillators in Heart Failure and Chronic Kidney Disease in the United States.

Journal Article Curr Probl Cardiol · April 2023 Chronic kidney disease (CKD) and hemodialysis increase the risk of sudden cardiac death (SCD) in heart failure (HF); however, national trends in utilization and outcomes of implantable cardioverter-defibrillator (ICD) in this population remain unknown. We ... Full text Link to item Cite

Trajectory of Decongestion and Mortality in Young Adults with Acute Heart Failure.

Journal Article Curr Probl Cardiol · April 2023 Although the prevalence of HF in young adults (age <50 years) is increasing, there are limited data on the trajectory of decongestion and short-term outcomes in young adults with acute heart failure (AHF). We pooled patients from 3 randomized trials of AHF ... Full text Link to item Cite

Trends in outcomes and resource utilization for acute myocardial infarction admissions during the COVID-19 pandemic.

Journal Article American heart journal · April 2023 During the early COVID-19 pandemic, resources were at times rationed, and as a result, cardiovascular outcomes may have suffered, however despite this, there is a paucity of national data specifically examining the relationship between COVID-19 and acute m ... Full text Cite

Intravenous iron infusion in patients with heart failure: a systematic review and study-level meta-analysis.

Journal Article ESC Heart Fail · April 2023 AIMS: There is considerable variability in the effect of intravenous iron on hard cardiovascular (CV)-related outcomes in patients with heart failure (HF) in randomized controlled trials (RCTs). We use a meta-analytic approach to analyse data from existing ... Full text Link to item Cite

Role of the Renal Lymphatic System in Heart Failure.

Journal Article Curr Heart Fail Rep · April 2023 PURPOSE OF REVIEW: The lymphatic system plays a major but overlooked role in maintaining fluid homeostasis. Given the unique fluid homeostasis functions of the kidneys, dysregulation of the renal lymphatic system underlies the development of self-propagati ... Full text Link to item Cite

Vericiguat for the treatment of heart failure with reduced ejection fraction.

Journal Article Expert Rev Cardiovasc Ther · April 2023 INTRODUCTION: Despite significant therapeutic advancements in heart failure with reduced ejection fraction (HFrEF), the residual risk of all-cause mortality and hospitalizations remains high among patients with HFrEF. Vericiguat is a novel oral soluble gua ... Full text Link to item Cite

Cardiac Resynchronization Therapy Improves Outcomes in Patients With Intraventricular Conduction Delay But Not Right Bundle Branch Block: A Patient-Level Meta-Analysis of Randomized Controlled Trials.

Journal Article Circulation · March 7, 2023 BACKGROUND: Benefit from cardiac resynchronization therapy (CRT) varies by QRS characteristics; individual randomized trials are underpowered to assess benefit for relatively small subgroups. METHODS: The authors analyzed patient-level data from pivotal CR ... Full text Link to item Cite

Continuous Monitoring of Heart Rate Variability and Clinical Outcomes in Patients with Implantable Cardioverter Defibrillators.

Journal Article Curr Probl Cardiol · March 2023 While heart rate variability (HRV) is an established marker of cardiovascular health, the extent to which continuously measured HRV changes over time and the relationship between these changes and clinical outcomes are less clear. We performed a health sys ... Full text Link to item Cite

In-Hospital Virtual Peer-to-Peer Consultation to Increase Guideline-Directed Medical Therapy for Heart Failure: A Pilot Randomized Trial.

Journal Article Circ Heart Fail · February 2023 BACKGROUND: Guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF) improves clinical outcomes and quality of life. Optimizing GDMT in the hospital is associated with greater long-term use in HFrEF. This study aim ... Full text Link to item Cite

Pressures do not equal volumes: implications for heart failure management in patients with CardioMEMS.

Journal Article ESC heart failure · February 2023 Pulmonary arterial pressures are often used as surrogates for intravascular blood volume. However, the relationship between pressure and volume remains controversial. To contextualize and provide concrete examples and impact on clinical management, we repo ... Full text Cite

Family income and cardiovascular disease risk in American adults.

Conference Sci Rep · January 6, 2023 Socioeconomic status is an overlooked risk factor for cardiovascular disease (CVD). Low family income is a measure of socioeconomic status and may portend greater CVD risk. Therefore, we assessed the association of family income with cardiovascular risk fa ... Full text Link to item Cite

Assessment of filling pressures and fluid overload in heart failure: an updated perspective.

Journal Article Rev Esp Cardiol (Engl Ed) · January 2023 Congestion plays a major role in the pathogenesis, presentation, and prognosis of heart failure and is an important therapeutic target. However, its severity and organ and compartment distribution vary widely among patients, illustrating the complexity of ... Full text Link to item Cite

Neuromodulation therapy for atrial fibrillation.

Journal Article Heart Rhythm · January 2023 Atrial fibrillation has a multifactorial pathophysiology influenced by cardiac autonomic innervation. Both sympathetic and parasympathetic influences are profibrillatory. Innovative therapies targeting the neurocardiac axis include catheter ablation or pha ... Full text Link to item Cite

Albuminuria and Heart Failure: JACC State-of-the-Art Review.

Journal Article Journal of the American College of Cardiology · January 2023 Although chronic kidney disease is characterized by low glomerular filtration rate (GFR) or albuminuria, estimated GFR (eGFR) is more widely utilized as a marker of risk profile in cardiovascular diseases, including heart failure (HF). The presence and mag ... Full text Cite

Impact of exercise on pulmonary artery pressure in patients with heart failure using an ambulatory pulmonary artery pressure monitor.

Journal Article Front Cardiovasc Med · 2023 BACKGROUND: In this multicenter prospective study, we explored the relationship between pulmonary artery pressure (PAP) at rest and in response to a 6-min walk test (6MWT) in ambulatory patients with heart failure (HF) with an implantable PAP sensor (Cardi ... Full text Link to item Cite

Efficacy and safety of sodium-glucose cotransporter-2 inhibitors for heart failure with mildly reduced or preserved ejection fraction: a systematic review and meta-analysis of randomized controlled trials.

Journal Article Front Cardiovasc Med · 2023 AIMS: We sought to conduct a meta-analysis to evaluate the efficacy and safety of sodium-glucose cotransporter-2 inhibitors (SGLT2i) in patients with heart failure (HF) with preserved ejection fraction (HFpEF) and HF with mildly reduced ejection fraction ( ... Full text Link to item Cite

Patient Selection and End Point Definitions for Decongestion Studies in Acute Decompensated Heart Failure: Part 2.

Journal Article J Soc Cardiovasc Angiogr Interv · 2023 Congestion is the most common manifestation of acute decompensated heart failure (ADHF). Residual congestion despite initial medical therapy is common and is recognized to be associated with worse outcomes; however, there are currently no standardized defi ... Full text Link to item Cite

Patient Selection and End Point Definitions for Decongestion Studies in Acute Decompensated Heart Failure: Part 1.

Journal Article J Soc Cardiovasc Angiogr Interv · 2023 Despite recent advances in the treatment of patients with chronic heart failure, acute decompensated heart failure remains associated with significant mortality and morbidity because many novel therapies have failed to demonstrate meaningful benefit. Persi ... Full text Link to item Cite

Role of Lymphatics in Heart Failure.

Journal Article J Soc Cardiovasc Angiogr Interv · 2023 The lymphatic system plays a crucial, yet often overlooked, role in maintaining fluid homeostasis, and its dysregulation is a key feature of heart failure (HF). Lymphatic dysregulation in patients with HF typically results from a combination of self-perpet ... Full text Link to item Cite

Multicenter registry and test bed for extended outpatient hemodynamic monitoring: the hemodynamic frontiers in heart failure (HF2) initiative.

Journal Article Front Cardiovasc Med · 2023 BACKGROUND: Hemodynamic Frontiers in Heart Failure (HF2) is a multicenter academic research consortium comprised of 14 US institutions with mature remote monitoring programs for ambulatory patients with heart failure (HF). The consortium developed a retros ... Full text Link to item Cite

ScoEHR: Generating Synthetic Electronic Health Records using Continuous-time Diffusion Models

Conference Proceedings of Machine Learning Research · January 1, 2023 Global access to statistically and clinically representative patient health data holds potential for advancing disease research, enhancing patient care, and accelerating drug development. However, acquisition of health data such as electronic health record ... Cite

Patient-reported and Clinical Outcomes Among Patients Hospitalized for Heart Failure With Reduced Versus Preserved Ejection Fraction.

Journal Article J Card Fail · December 2022 BACKGROUND: Differences between patients hospitalized for heart failure with reduced ejection fraction (HFrEF) vs HF with preserved EF (HFpEF) are not well-characterized, particularly as pertains to in-hospital decongestion and longitudinal patient-reporte ... Full text Link to item Cite

Non-Alcoholic Fatty Liver Disease, Heart Failure, and Long-Term Mortality: Insights From the National Health and Nutrition Examination Survey.

Journal Article Curr Probl Cardiol · December 2022 To evaluate the association between non-alcoholic fatty liver disease (NAFLD), heart failure (HF), and all-cause mortality. Both NAFLD and HF are increasing in prevalence due to shared risk factors. We used data from the National Health and Nutrition Exami ... Full text Link to item Cite

Evaluation and Treatment of Central Sleep Apnea in Patients with Heart Failure.

Journal Article Curr Probl Cardiol · December 2022 Sleep-disordered breathing (SDB) is a common comorbidity in patients with heart failure (HF). Prevalence of the most common subtypes of SDB, central sleep apnea (CSA) and obstructive sleep apnea (OSA), is increasing, which is concerning due to the associat ... Full text Link to item Cite

Current status of perioperative temporary mechanical circulatory support during cardiac surgery.

Journal Article J Card Surg · December 2022 OBJECTIVES: We sought to determine utilization and outcomes of perioperative temporary mechanical circulatory support (tMCS) in the current practice of cardiac surgery. BACKGROUND: tMCS is an evolving adjunct to cardiac surgery not fully characterized in c ... Full text Link to item Cite

Blood volume and chronic kidney disease in heart failure - Can volume expansion help balance the Cardio-Renal Axis for better clinical outcomes?

Journal Article Physiol Rep · December 2022 Intravascular volume is largely regulated by the kidneys but how differences in intravascular volume profiles interact with chronic kidney disease (CKD) to influence outcomes in chronic heart failure (HF) has not been explored. Our hypothesis was that a gr ... Full text Link to item Cite

Residual stroke risk despite oral anticoagulation in patients with atrial fibrillation.

Journal Article Heart Rhythm O2 · December 2022 BACKGROUND: Oral anticoagulation (OAC) reduces the risk of thromboembolic events in patients with atrial fibrillation (AF); however, thromboembolism (TE) still can occur despite OAC. Factors associated with residual risk for stroke, systemic embolism, or t ... Full text Link to item Cite

[Cardiac contractility modulation in heart failure with reduced ejection fraction treatment].

Journal Article Kardiologiia · November 30, 2022 Heart failure with reduced left ventricular ejection fraction (LV EF) (HFrEF) is a significant issue of health care due to increasing indexes of morbidity and mortality. The emergence of a number of drugs and implantable devices for the treatment of HFrEF ... Full text Link to item Cite

Characteristics and Outcomes of Suspected Digoxin Toxicity and Immune Fab Treatment Over the Past Two Decades-2000-2020.

Journal Article Am J Cardiol · November 15, 2022 The role of digoxin in clinical practice has narrowed over time. Data on digoxin toxicity trends and outcomes are variable and lack granularity for treatment outcomes. This study aimed to address data gaps in digoxin toxicity trends and outcomes in patient ... Full text Link to item Cite

Prognostic significance of obstructive coronary artery disease in patients admitted with acute decompensated heart failure: the ARIC study community surveillance.

Conference Eur J Heart Fail · November 2022 AIMS: We aimed to investigate the impact of obstructive coronary artery disease (CAD) in patients with acute decompensated heart failure (ADHF), and examine potential differences in prognostic utility for heart failure with reduced (HFrEF) versus preserved ... Full text Link to item Cite

Device Therapy for Heart Failure with Preserved Ejection Fraction.

Journal Article Cardiol Clin · November 2022 Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome with few options for effective pharmacologic therapies. Numerous device-based approaches to HFpEF therapy have emerged, which aim to treat the clinical and pathophysiologic ... Full text Link to item Cite

Synchronized Diaphragmatic Stimulation for Heart Failure With a Reduced Left Ventricular Ejection Fraction Using the VisONE System: A First-in-Patient Study With Extended Population.

Journal Article Struct Heart · November 2022 BACKGROUND: Synchronized diaphragmatic stimulation (SDS) produces localized contractions of the diaphragm gated to the cardiac cycle to transiently modulate intrathoracic pressures, thereby impacting cardiac function for heart failure patients with reduced ... Full text Link to item Cite

Neighborhood Socioeconomic Disadvantage and Hospitalized Heart Failure Outcomes in the American Heart Association Get With The Guidelines-Heart Failure Registry.

Journal Article Circ Heart Fail · November 2022 BACKGROUND: Neighborhood socioeconomic status (SES) is associated with worse health outcomes, yet its relationship with in-hospital heart failure (HF) outcomes and quality metrics are underexplored. We examined the association between socioeconomic neighbo ... Full text Link to item Cite

Clinical determinants and prognostic significance of hypocapnia in acute heart failure.

Journal Article Sci Rep · October 7, 2022 The aim of this research was to examine the prevalence of hyperventilation (defined by pCO2 value) among acute heart failure (AHF) patients and to link it with potential triggers and prognosis. All patients underwent dyspnea severity assessment and capilla ... Full text Link to item Cite

Trends and Inpatient Outcomes of Primary Atrial Fibrillation Hospitalizations with Underlying Iron Deficiency Anemia: An Analysis of The National Inpatient Sample Database from 2004 -2018.

Journal Article Curr Probl Cardiol · October 2022 Atrial fibrillation (AF) is the most prevalent arrhythmia in the United States. However, studies evaluating the impact of iron deficiency anemia on AF outcomes are limited. Therefore, we aimed to evaluate the association of iron deficiency anemia (IDA) on ... Full text Link to item Cite

Sodium-Glucose Cotransporter 2 Inhibitors and Cardiac Remodeling.

Journal Article J Cardiovasc Transl Res · October 2022 Sodium-glucose cotransporter 2 (SGLT2) inhibitors have evident cardiovascular benefits in patients with type 2 diabetes with or at high risk for atherosclerotic cardiovascular disease, heart failure with reduced ejection fraction, heart failure with preser ... Full text Link to item Cite

National trends and disparities in statin use for ischemic heart disease from 2006 to 2018: Insights from National Ambulatory Medical Care Survey.

Journal Article Am Heart J · October 2022 BACKGROUND: Statins are a cornerstone guideline-directed medical therapy for secondary prevention of ischemic heart disease (IHD). However, recent temporal trends and disparities in statin utilization for IHD have not been well characterized. METHODS: This ... Full text Link to item Cite

Transvenous Right Greater Splanchnic Nerve Ablation in Heart Failure and Preserved Ejection Fraction: First-in-Human Study.

Journal Article JACC Heart Fail · October 2022 BACKGROUND: Ablation of the right-sided greater splanchnic nerve (GSN) can reduce excessive splanchnic vasoconstriction, potentially improving the handling of volume shifts in patients with heart failure with preserved ejection fraction (HFpEF). OBJECTIVES ... Full text Link to item Cite

Sodium-glucose Cotransporter 2 Inhibitors and Nonalcoholic Fatty Liver Disease.

Journal Article Heart Fail Clin · October 2022 Nonalcoholic fatty liver disease (NAFLD) is a systemic disorder with cardiovascular manifestations; due to its complex and multifactorial pathophysiological mechanisms, no effective pharmacologic treatment has been identified to date. Sodium-glucose cotran ... Full text Link to item Cite

In HFpEF, the benefit of empagliflozin on a composite of CV death or HF hospitalization at 26 mo did not vary by diabetes status.

Journal Article Ann Intern Med · October 2022 Filippatos G, Butler J, Farmakis D, et al. Empagliflozin for heart failure with preserved left ventricular ejection fraction with and without diabetes. Circulation. 2022;146:676-86. 35762322. ... Full text Link to item Cite

Diaphragmatic Function in Cardiovascular Disease: JACC Review Topic of the Week.

Journal Article Journal of the American College of Cardiology · October 2022 In addition to the diaphragm's role as the primary respiratory muscle, it also plays an under-recognized role in cardiac function. It serves as a pump facilitating venous and lymph return, modulating left ventricular afterload hemodynamics and pericardial ... Full text Cite

Quantitative Blood Volume Analysis and Hemodynamic Measures of Vascular Compliance in Patients With Worsening Heart Failure.

Journal Article J Card Fail · September 2022 BACKGROUND: The role of blood volume (BV) expansion vs a change in vascular compliance in worsening heart failure (HF) remains under debate. We aimed to assess the relationship between BV and resting and stress hemodynamics in worsening HF and to further e ... Full text Link to item Cite

Baroreflex activation therapy with the Barostim™ device in patients with heart failure with reduced ejection fraction: a patient level meta-analysis of randomized controlled trials.

Journal Article Eur J Heart Fail · September 2022 AIMS: Heart failure with reduced ejection fraction (HFrEF) remains associated with high morbidity and mortality, poor quality of life (QoL) and significant exercise limitation. Sympatho-vagal imbalance has been shown to predict adverse prognosis and sympto ... Full text Link to item Cite

Are We Getting Any Closer to Understanding Congestion?

Journal Article JACC Heart Fail · September 2022 Full text Link to item Cite

Contemporary Applications of Machine Learning for Device Therapy in Heart Failure.

Journal Article JACC Heart Fail · September 2022 Despite a better understanding of the underlying pathogenesis of heart failure (HF), pharmacotherapy, surgical, and percutaneous interventions do not prevent disease progression in all patients, and a significant proportion of patients end up requiring adv ... Full text Link to item Cite

Demographic and Regional Trends of Hypertrophic Cardiomyopathy-Related Mortality in the United States, 1999 to 2019.

Journal Article Circ Heart Fail · September 2022 BACKGROUND: Hypertrophic cardiomyopathy (HCM)-related mortality has been decreasing within the United States; however, persistent disparities in demographic subsets may exist. In this study, we assessed nationwide trends in mortality related to HCM among p ... Full text Link to item Cite

Prevalence and Prognostic Significance of Polyvascular Disease in Patients Hospitalized With Acute Decompensated Heart Failure: The ARIC Study.

Journal Article J Card Fail · August 2022 BACKGROUND: Polyvascular disease is associated with increased mortality rates and decreased quality of life. Whether its prevalence or associated outcomes differ for patients hospitalized with heart failure with reduced vs preserved ejection fraction (HFrE ... Full text Link to item Cite

Trends and Characteristics of Hospitalizations in Patients With Heart Transplant.

Journal Article Curr Probl Cardiol · August 2022 There is limited data regarding the leading causes of hospitalization among heart transplant (HT) recipients and the characteristics of these hospitalizations. We conducted a retrospective analysis of the National Inpatient Sample weighted data between Jan ... Full text Link to item Cite

Endovascular ablation of the right greater splanchnic nerve in heart failure with preserved ejection fraction: early results of the REBALANCE-HF trial roll-in cohort.

Journal Article Eur J Heart Fail · August 2022 AIMS: In heart failure (HF) with preserved ejection fraction (HFpEF), excessive redistribution of blood volume into the central circulation leads to elevations of intracardiac pressures with exercise limitations. Splanchnic ablation for volume management ( ... Full text Link to item Cite

Synchronized diaphragmatic stimulation for heart failure using the VisONE system: a first-in-patient study.

Journal Article ESC Heart Fail · August 2022 AIMS: Synchronized diaphragmatic stimulation (SDS) modulates intrathoracic and intra-abdominal pressures with favourable effects on cardiac function for patients with a reduced left ventricular ejection fraction (LVEF) and heart failure (HFrEF). VisONE-HF ... Full text Link to item Cite

Post-recovery COVID-19 and incident heart failure in the National COVID Cohort Collaborative (N3C) study.

Journal Article Nat Commun · July 15, 2022 Cardiac involvement has been noted in COVID-19 infection. However, the relationship between post-recovery COVID-19 and development of de novo heart failure has not been investigated in a large, nationally representative population. We examined post-recover ... Full text Link to item Cite

Impact of the heart transplant allocation policy change on inpatient cost of index hospitalization.

Journal Article Clin Transplant · July 2022 BACKGROUND: We sought to determine the financial impact of the United Network for Organ Sharing heart transplant (HT) allocation policy change of October 2018. METHODS: Using the Nationwide Inpatient Sample we retrospectively analyzed hospital discharge da ... Full text Link to item Cite

Catheter-Based Management of Heart Failure: Pathophysiology and Contemporary Data.

Journal Article Interv Cardiol Clin · July 2022 Device therapy for severe heart failure (HF) has shown efficacy both in acute and chronic settings. Recent percutaneous device innovations have pioneered a field known as interventional HF, providing clinicians with a variety of options for acute decompens ... Full text Link to item Cite

The Clinical Problem of Pelvic Venous Disorders.

Journal Article Interv Cardiol Clin · July 2022 Pelvic venous disorders are inter-related pathologic conditions caused by reflux and obstruction in the pelvic veins. It can present a spectrum of clinical features based on the route of transmission of venous hypertension to either distal or caudal venous ... Full text Link to item Cite

Synchronized diaphragmatic stimulation: a case report of a novel extra-cardiac intervention for chronic heart failure.

Journal Article ESC Heart Fail · June 2022 Synchronized diaphragmatic stimulation (SDS) is a novel extra-cardiac device-based therapy for symptomatic heart failure with reduced ejection fraction. SDS provides imperceptible chronic stimulation of the diaphragm through a laparoscopically implanted sy ... Full text Link to item Cite

Hemodynamic and Clinical Determinants of Left Atrial Enlargement in Liver Transplant Candidates.

Journal Article Am J Cardiol · June 1, 2022 New-onset heart failure is a frequent complication after orthotopic liver transplantation (OLT). Left atrial enlargement (LAE) may be a sign of occult left heart disease. Our primary objective was to determine invasive hemodynamic and clinical predictors o ... Full text Link to item Cite

Clinical Prediction Models for Heart Failure Hospitalization in Type 2 Diabetes: A Systematic Review and Meta-Analysis.

Journal Article J Am Heart Assoc · May 17, 2022 Background Clinical prediction models have been developed for hospitalization for heart failure in type 2 diabetes. However, a systematic evaluation of these models' performance, applicability, and clinical impact is absent. Methods and Results We searched ... Full text Link to item Cite

Venous Tone and Stressed Blood Volume in Heart Failure: JACC Review Topic of the Week.

Journal Article J Am Coll Cardiol · May 10, 2022 A number of pathologic processes contribute to the elevation in cardiac filling pressures in heart failure (HF), including myocardial dysfunction and primary volume overload. In this review, we discuss the important role of the venous system and the concep ... Full text Link to item Cite

Trends in Characteristics and Outcomes in Primary Heart Failure Hospitalizations Among Older Population in the United States, 2004 to 2018.

Journal Article Circ Heart Fail · May 2022 BACKGROUND: Heart failure (HF) accounts for a significant proportion of morbidity, mortality, and health care costs among older adults in the United States. We evaluated trends in clinical outcomes and the economic burden of HF hospitalizations in older pa ... Full text Link to item Cite

The heart transplant allocation change attenuates but does not eliminate blood group O waitlist outcome disadvantage.

Journal Article Clin Transplant · May 2022 BACKGROUND: Patients with blood group O have historically been disadvantaged in the United Network for Organ Sharing (UNOS) heart transplant allocation system. We sought to determine whether the new UNOS allocation system implemented in 2018 had an impact ... Full text Link to item Cite

Trends in Characteristics and Outcomes of Peripartum Cardiomyopathy Hospitalizations in the United States Between 2004 and 2018.

Journal Article Am J Cardiol · April 1, 2022 Data are limited on contemporary temporal trends in maternal characteristics and outcomes in hospitalized patients with peripartum cardiomyopathy (PC). We used the National Inpatient Sample database from January 1, 2004, to December 31, 2018, to identify P ... Full text Link to item Cite

Trends and characteristics of hospitalizations for heart failure in the United States from 2004 to 2018.

Journal Article ESC Heart Fail · April 2022 AIMS: Hospitalization for heart failure (HF) constitutes a major healthcare and economic burden. Trends and characteristics of hospitalizations for HF for the recent years are not clear. We sought to determine the trends and characteristics of hospitalizat ... Full text Link to item Cite

Renal effects of guideline-directed medical therapies in heart failure: a consensus document from the Heart Failure Association of the European Society of Cardiology.

Journal Article Eur J Heart Fail · April 2022 Novel pharmacologic treatment options reduce mortality and morbidity in a cost-effective manner in patients with heart failure (HF). Undisputedly, the effective implementation of these agents is an essential element of good clinical practice, which is endo ... Full text Link to item Cite

Major adverse cardiac events in symptomatic women with non-obstructive CAD on coronary CTA: pooled analysis from PROMISE and SCOT-HEART.

Journal Article Int J Cardiovasc Imaging · March 2022 The presence of non-obstructive coronary artery disease (CAD) on coronary computed tomography angiography (CTA) has been associated with the occurrence of major adverse cardiac events (MACE). However, factors associated with the development of MACE in symp ... Full text Link to item Cite

Changes in inferior vena cava area represent a more sensitive metric than changes in filling pressures during experimental manipulation of intravascular volume and tone.

Journal Article Eur J Heart Fail · March 2022 AIMS: Remote monitoring of pulmonary artery pressure has reduced heart failure (HF) hospitalizations in chronic HF as elevation of pulmonary artery pressure provides information that can guide treatment. The venous system is characterized by high capacitan ... Full text Link to item Cite

Targeting Preload in Heart Failure: Splanchnic Nerve Blockade and Beyond.

Journal Article Circ Heart Fail · March 2022 Preload augmentation represents a critical mechanism for the cardiovascular system to increase effective circulating blood volume to increase cardiac filling pressures and, subsequently, for the heart to increase cardiac output. The splanchnic vascular com ... Full text Link to item Cite

Early Hemodynamic Changes following Surgical Ablation of the Right Greater Splanchnic Nerve for the Treatment of Heart Failure with Preserved Ejection Fraction.

Journal Article J Clin Med · February 18, 2022 BACKGROUND: Permanent ablation of the right greater splanchnic nerve (GSN) has previously been demonstrated to improve quality of life and functional outcomes, as well as reduce abnormally high intracardiac filling pressures, in patients with heart failure ... Full text Link to item Cite

Efficacy and safety of sodium-glucose cotransporter 2 inhibitors initiation in patients with acute heart failure, with and without type 2 diabetes: a systematic review and meta-analysis.

Journal Article Cardiovasc Diabetol · February 5, 2022 BACKGROUND: There is uncertainty and limited data regarding initiation of sodium-glucose cotransporter 2 (SGLT2) inhibitors among patients hospitalized with acute heart failure (AHF). This systematic review and meta-analysis aim to establish the efficacy a ... Full text Link to item Cite

A Machine Learning Methodology for Identification and Triage of Heart Failure Exacerbations.

Journal Article J Cardiovasc Transl Res · February 2022 Inadequate at-home management and self-awareness of heart failure (HF) exacerbations are known to be leading causes of the greater than 1 million estimated HF-related hospitalizations in the USA alone. Most current at-home HF management protocols include p ... Full text Link to item Cite

Contemporary Nationwide Heart Transplantation and Left Ventricular Assist Device Outcomes in Patients with Histories of Bariatric Surgery.

Journal Article J Card Fail · February 2022 Bariatric surgery may play a role in the management of morbidly obese patients with end-stage heart failure through increasing eligibility and improving the outcomes of destination therapies. We conducted a nationally representative, retrospective cohort s ... Full text Link to item Cite

Demographic and Regional Trends of Mortality in Patients With Acute Myocardial Infarction in the United States, 1999 to 2019.

Journal Article Am J Cardiol · February 1, 2022 Acute myocardial infarction (AMI)-related mortality has been decreasing within the United States because of improvements in management and preventive efforts; however, persistent disparities in demographic subsets such as race may exist. In this study, the ... Full text Link to item Cite

Evaluation of Representation of Women as Authors in Pivotal Trials Supporting US Food and Drug Administration Approval of Novel Cardiovascular Drugs.

Journal Article JAMA Netw Open · February 1, 2022 This cross-sectional study evaluates the representation of women as authors of pivotal trials of novel cardiovascular drugs approved by the US Food and Drug Administration between 2008 and 2020. ... Full text Link to item Cite

Pericardial Adipose Tissue Volume and Left Ventricular Assist Device-Associated Outcomes.

Journal Article J Card Fail · January 2022 BACKGROUND: Pericardial adipose tissue (PAT) is associated with adverse cardiovascular outcomes in those with and without established heart failure (HF). However, it is not known whether PAT is associated with adverse outcomes in patients with end-stage HF ... Full text Link to item Cite

Trends in hospitalizations for heart failure, acute myocardial infarction, and stroke in the United States from 2004 to 2018.

Journal Article Am Heart J · January 2022 AIM: To determine the trends in hospitalizations for heart failure (HF), acute myocardial infarction (AMI), and stroke in the United States (US). METHOD AND RESULTS: A retrospective analysis of the National Inpatient Sample weighted data between January 1, ... Full text Link to item Cite

Prognosis for patients with heart failure and reduced ejection fraction with and without diabetes: A 7 year nationwide veteran administration analysis.

Journal Article Int J Cardiol · January 1, 2022 OBJECTIVE: Evidence suggests diabetes mellitus is an independent risk factor for adverse cardiovascular events in patients with heart failure. As a result, we sought to compare mortality in patients with heart failure with reduced ejection fraction (HFrEF) ... Full text Link to item Cite

Low level of neutrophil gelatinase-associated lipocalin (NGAL) in patients with chronic heart failure and multivessel coronary atherosclerosis

Journal Article Russian Open Medical Journal · January 1, 2022 Rationale - Several biomarkers are used to determine the prognosis of patients with heart failure (HF), including neutrophil gelatinase-associated lipocalin (NGAL, Lipocalin-2). We investigated NGAL serum levels in patients with HF and coronary artery dise ... Full text Cite

Significance of indeterminate and abnormal stress electrocardiography despite normal imaging in patients with suspected coronary artery disease - An analysis of the PROMISE trial.

Journal Article J Electrocardiol · 2022 BACKGROUND: Abnormal and indeterminate electrocardiographic (ECG) changes during cardiac stress imaging are not uncommon. While the prognostic importance of abnormal ECG despite normal imaging has been previously studied, prognosis of indeterminate stress ... Full text Link to item Cite

Neuromodulation Strategies to Reduce Inflammation and Improve Lung Complications in COVID-19 Patients.

Journal Article Front Neurol · 2022 Since the outbreak of the COVID-19 pandemic, races across academia and industry have been initiated to identify and develop disease modifying or preventative therapeutic strategies has been initiated. The primary focus has been on pharmacological treatment ... Full text Link to item Cite

Therapeutic targeting of splanchnic nerves

Chapter · January 1, 2022 The venous capacitance of the splanchnic vascular bed plays a pivotal role across the cardiovascular disease spectrum, and at the opposing extremes of that spectrum are patients with heart failure and dysautonomia. One possible mechanism of heart failure e ... Full text Cite

Distinct renin/aldosterone activity profiles correlate with renal function, natriuretic response, decongestive ability and prognosis in acute heart failure.

Journal Article Int J Cardiol · December 15, 2021 BACKGROUND: Although renin-angiotensin-aldosterone system (RAAS) activation is believed to be the major driver of acute heart failure (AHF) episodes our understanding of its prevalence and clinical relevance in contemporary settings is incomplete. METHODS: ... Full text Link to item Cite

Relation of left atrial function with exercise capacity and muscle endurance in patients with heart failure.

Journal Article ESC Heart Fail · December 2021 AIMS: Both left atrial strain (LAS) and skeletal muscle endurance demonstrate a linear relationship to peak VO2 . Less is known about the relationship between central (cardiac) and peripheral (muscle endurance) limitations of exercise capacity in patients ... Full text Link to item Cite

Temporal Trends and Prognosis of Physical Examination Findings in Patients With Acute Decompensated Heart Failure: The ARIC Study Community Surveillance.

Journal Article Circ Heart Fail · December 2021 BACKGROUND: Bedside evaluation of congestion is a mainstay of heart failure (HF) management. Whether detected physical examination signs have changed over time as obesity prevalence has increased in HF populations, or if the associated prognosis differs fo ... Full text Link to item Cite

Nonalcoholic Fatty Liver Disease and Risk of Heart Failure Among Medicare Beneficiaries.

Journal Article J Am Heart Assoc · November 16, 2021 Background Nonalcoholic fatty liver disease (NAFLD) and heart failure (HF) are increasing in prevalence. The independent association between NAFLD and downstream risk of HF and HF subtypes (HF with preserved ejection fraction and HF with reduced ejection f ... Full text Link to item Cite

Drugs of Abuse and Heart Failure.

Journal Article J Card Fail · November 2021 Substance use is common among those with heart failure (HF) and is associated with worse clinical outcomes. Alcohol, tobacco, cannabis, and cocaine are commonly abused substances that can contribute to the development and worsening of HF. Heavy alcohol con ... Full text Link to item Cite

Clinical and Echocardiographic Characteristics of Patients Hospitalized With Acute Versus Chronic Heart Failure With Preserved Ejection Fraction (From the ARIC Study).

Journal Article Am J Cardiol · November 1, 2021 An expanding number of therapies are now indicated for comorbidity management in heart failure with preserved ejection fraction (HFpEF). Whether comorbidity burdens differ for patients with HFpEF who are hospitalized for acute decompensated heart failure ( ... Full text Link to item Cite

Phenotyping heart failure patients for iron deficiency and use of intravenous iron therapy: data from the Swedish Heart Failure Registry.

Journal Article Eur J Heart Fail · November 2021 AIMS: Iron deficiency (ID) is associated with poor prognosis regardless of anaemia. Intravenous iron improves quality of life and outcomes in patients with ID and heart failure (HF) with reduced ejection fraction (HFrEF). In the Swedish HF registry, we ass ... Full text Link to item Cite

Relationship of Nonalcoholic Fatty Liver Disease and Heart Failure With Preserved Ejection Fraction.

Journal Article JACC Basic Transl Sci · November 2021 Although there is an established bidirectional relationship between heart failure with reduced ejection fraction and liver disease, the association between heart failure with preserved ejection fraction (HFpEF) and liver diseases, such as nonalcoholic fatt ... Full text Link to item Cite

Mechanical dyssynchrony: How do we measure it, what it means, and what we can do about it.

Journal Article J Nucl Cardiol · October 2021 Left ventricular mechanical dyssynchrony (LVMD) is defined by a difference in the timing of mechanical contraction or relaxation between different segments of the left ventricle (LV). Mechanical dyssynchrony is distinct from electrical dyssynchrony as meas ... Full text Link to item Cite

Clinical Phenotypes in Patients With Type 2 Diabetes Mellitus: Characteristics, Cardiovascular Outcomes and Treatment Strategies.

Journal Article Curr Heart Fail Rep · October 2021 PURPOSE OF REVIEW: With recent advances in the pharmacological management of type 2 diabetes mellitus (T2DM), there is a growing need to understand which patients optimally benefit from these novel therapies. Various clinical clustering methodologies have ... Full text Link to item Cite

Early Identification of Patients at Risk for Incident Heart Failure With Preserved Ejection Fraction: Novel Approach to Echocardiographic Trends.

Journal Article J Card Fail · September 2021 BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) continues to increase in prevalence with a 50% mortality rate within 3 years of diagnosis, but lacking effective evidence-based therapies. Specific echocardiographic markers are not typical ... Full text Link to item Cite

Pre-operative atrial fibrillation and early right ventricular failure after left ventricular assist device implantation: a systematic review and meta-analysis.

Journal Article Am Heart J · September 2021 BACKGROUND: Right ventricular failure (RVF) remains a major cause of morbidity and mortality after left ventricular assist device (LVAD). Atrial fibrillation (AF) is known for its deleterious effects on cardiac function and hemodynamics. The association of ... Full text Link to item Cite

Early diuretic strategies and the association with In-hospital and Post-discharge outcomes in acute heart failure.

Journal Article Am Heart J · September 2021 BACKGROUND: Decongestion is a primary goal during hospitalizations for decompensated heart failure (HF). However, data surrounding the preferred route and strategy of diuretic administration are limited with varying results in prior studies. METHODS: This ... Full text Link to item Cite

Dietary interventions and nutritional supplements for heart failure: a systematic appraisal and evidence map.

Journal Article Eur J Heart Fail · September 2021 AIMS: To appraise meta-analytically determined effect of dietary interventions and nutritional supplements on heart failure (HF)-related outcomes, and create an evidence map to visualize the findings and certainty of evidence. METHODS AND RESULTS: Online d ... Full text Link to item Cite

Device Therapy in Chronic Heart Failure: JACC State-of-the-Art Review.

Journal Article J Am Coll Cardiol · August 31, 2021 The regulatory landscape for device-based heart failure (HF) therapies has seen a major shift in the last 7 years. In 2013, the U.S. Food and Drug Administration released guidance for early feasibility and first-in-human studies, thereby encouraging device ... Full text Link to item Cite

Spot urine sodium in acute heart failure: differences in prognostic value on admission and discharge.

Journal Article ESC Heart Fail · August 2021 AIMS: Most studies examined spot urine sodium's (sUNa+ ) prognostic utility during the early phase of acute heart failure (AHF) hospitalization. In AHF, sodium excretion is related to clinical status; therefore, we investigated the differences in the progn ... Full text Link to item Cite

Extra-cardiac targets in the management of cardiometabolic disease: Device-based therapies.

Journal Article ESC Heart Fail · August 2021 Heart failure (HF) does not occur in a vacuum and is commonly defined and exacerbated by its co-morbid conditions. Neurohormonal imbalance and systemic inflammation are some of the key pathomechanisms of HF but also commonly encountered co-morbidities such ... Full text Link to item Cite

Growth differentiation factor-15, treatment with liraglutide, and clinical outcomes among patients with heart failure.

Journal Article ESC Heart Fail · August 2021 AIMS: Associations between growth differentiation factor-15 (GDF-15), cardiovascular outcomes, and exercise capacity among patients with a recent hospitalization for heart failure (HHF) and heart failure with reduced ejection fraction (HFrEF) are unknown. ... Full text Link to item Cite

Causes of hospitalization in the USA between 2005 and 2018.

Journal Article Eur Heart J Open · August 2021 In this report, we identify the 10 most common causes of hospitalizations in the USA in 2005-2018 using the discharge data from the National Inpatient Sample database. We show that sepsis has been the leading cause of hospitalizations in the USA followed b ... Full text Link to item Cite

Regional Adiposity and Risk of Heart Failure and Mortality: The Jackson Heart Study.

Journal Article J Am Heart Assoc · July 20, 2021 Background Visceral adipose tissue (VAT) is associated with incident heart failure (HF) and HF with preserved ejection fraction, yet it is unknown how pericardial and abdominal adiposity affect HF and mortality risks in Black individuals. We examined the a ... Full text Link to item Cite

Lymphatic Dysregulation in Patients With Heart Failure: JACC Review Topic of the Week.

Journal Article J Am Coll Cardiol · July 6, 2021 The lymphatic system is an integral part of the circulatory system and plays an important role in the volume homeostasis of the human body. The complex anatomy and physiology paired with a lack of simple diagnostic tools to study the lymphatic system have ... Full text Link to item Cite

Splanchnic nerve modulation in heart failure: mechanistic overview, initial clinical experience, and safety considerations.

Journal Article Eur J Heart Fail · July 2021 Volume recruitment from the splanchnic compartment is an important physiological response to stressors such as physical activity and blood loss. In the setting of heart failure (HF), excess fluid redistribution from this compartment leads to increased card ... Full text Link to item Cite

Surgical ablation of the right greater splanchnic nerve for the treatment of heart failure with preserved ejection fraction: first-in-human clinical trial.

Journal Article European journal of heart failure · July 2021 AimsInappropriate control of blood volume redistribution may be a mechanism responsible for exercise intolerance in heart failure with preserved ejection fraction (HFpEF). We propose to address this underlying pathophysiology with selective blocka ... Full text Cite

Acute cardiovascular hospitalizations and illness severity before and during the COVID-19 pandemic.

Journal Article Clin Cardiol · May 2021 BACKGROUND: Cardiovascular disease (CVD) hospitalizations declined worldwide during the COVID-19 pandemic. It is unclear how shelter-in-place orders affected acute CVD hospitalizations, illness severity, and outcomes. HYPOTHESIS: COVID-19 pandemic was asso ... Full text Link to item Cite

Association of liver fibrosis risk scores with clinical outcomes in patients with heart failure with preserved ejection fraction: findings from TOPCAT.

Journal Article ESC Heart Fail · April 2021 AIMS: Non-alcoholic fatty liver disease leads to progressive liver fibrosis and appears to be a frequent co-morbid disease in heart failure with preserved ejection fraction (HFpEF). It is well known that liver fibrosis severity predicts future liver-relate ... Full text Link to item Cite

Splanchnic Nerve Block Mediated Changes in Stressed Blood Volume in Heart Failure.

Journal Article JACC Heart Fail · April 2021 OBJECTIVES: The authors estimated changes of stressed blood volume (SBV) induced by splanchnic nerve block (SNB) in patients with either decompensated or ambulatory heart failure with reduced ejection fraction (HFrEF). BACKGROUND: The splanchnic vascular c ... Full text Link to item Cite

Eligibility for sacubitril/valsartan in heart failure across the ejection fraction spectrum: real-world data from the Swedish Heart Failure Registry.

Journal Article J Intern Med · March 2021 BACKGROUND: Randomized controlled trials (RCT) generalizability may be limited due to strict patient selection. OBJECTIVE: In a real-world heart failure (HF) population, we assessed eligibility for sacubitril/valsartan based on PARADIGM-HF (sacubitril/vals ... Full text Link to item Cite

Plasma Volume Status and Its Association With In-Hospital and Postdischarge Outcomes in Decompensated Heart Failure.

Journal Article J Card Fail · March 2021 BACKGROUND: Prior analyses suggest an association between formula-based plasma volume (PV) estimates and outcomes in heart failure (HF). We assessed the association between estimated PV status by the Duarte-ePV and Kaplan Hakim (KH-ePVS) formulas, and in-h ... Full text Link to item Cite

Contemporary Use of Venoarterial Extracorporeal Membrane Oxygenation: Insights from the Multicenter RESCUE Registry.

Conference J Card Fail · March 2021 BACKGROUND: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used as a life-saving therapy for patients with cardiovascular collapse, but identifying patients unlikely to benefit remains a challenge. METHODS AND RESULTS: We create ... Full text Link to item Cite

Effects of sodium-glucose cotransporter 1 and 2 inhibitors on cardiovascular and kidney outcomes in type 2 diabetes: A meta-analysis update.

Journal Article Am Heart J · March 2021 In this report, we aim to provide an updated meta-analysis of the sodium-glucose cotransporter 2 (SGLT2) inhibitors trial data with the new trial data on sotagliflozin, a first-in-class dual SGLT1 and SGLT2 inhibitor. We searched Medline, Cochrane library, ... Full text Link to item Cite

Obesity and Outcomes Following Cardiogenic Shock Requiring Acute Mechanical Circulatory Support.

Journal Article Circ Heart Fail · March 2021 BACKGROUND: The association of obesity on outcomes in patients with cardiogenic shock requiring acute mechanical circulatory support has not been thoroughly investigated. METHODS: We evaluated the National Readmission Database for adults with either acute ... Full text Link to item Cite

Impact of Atrial Fibrillation on In-Hospital Mortality and Thromboembolic Complications after Left Ventricular Assist Device Implantation.

Journal Article J Cardiovasc Transl Res · February 2021 The association between atrial fibrillation (AF) and thromboembolic (TE) complications in left ventricular assist device (LVAD) recipients is controversial, and there is paucity of large-scale data evaluating the impact of AF on early outcomes after device ... Full text Link to item Cite

Effect of sodium-glucose cotransporter 2 inhibitors on cardiovascular and kidney outcomes-Systematic review and meta-analysis of randomized placebo-controlled trials.

Journal Article Am Heart J · February 2021 UNLABELLED: Sodium-glucose cotransporter 2 inhibitor (SGLT2i) use is associated with improved cardiovascular and kidney outcomes. However, the magnitude and potential heterogeneity of effect across patients with varying types of cardiometabolic and kidney ... Full text Link to item Cite

Implications of peripheral oedema in heart failure with preserved ejection fraction: a heart failure network analysis.

Journal Article ESC Heart Fail · February 2021 AIMS: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous condition, and tissue congestion manifested by oedema is not present in all patients. We compared clinical characteristics, exercise capacity, and outcomes in patients with HFp ... Full text Link to item Cite

Novel findings of respiratory rate increases using the multisensor HeartLogic heart failure monitoring algorithm in COVID-19-positive patients: a case series.

Journal Article Eur Heart J Case Rep · February 2021 BACKGROUND: With the ongoing coronavirus disease 2019 (COVID-19) epidemic, remote monitoring of patients with implanted cardiac devices has become more important than ever, as physical distancing measures have placed limits on in-clinic device monitoring. ... Full text Link to item Cite

A current and future outlook on upcoming technologies in remote monitoring of patients with heart failure.

Journal Article Eur J Heart Fail · January 2021 Heart failure is a major health and economic challenge in both developing and developed countries. Despite advances in pharmacological and device therapies for patients with a reduced left ventricular ejection fraction (LVEF) and heart failure, their quali ... Full text Link to item Cite

The Degree of the Predischarge Pulmonary Congestion in Patients Hospitalized for Worsening Heart Failure Predicts Readmission and Mortality.

Journal Article Cardiology · 2021 BACKGROUND: Prediction of readmission and death after hospitalization for heart failure (HF) is an unmet need. AIM: We evaluated the ability of clinical parameters, NT-proBNP level and noninvasive lung impedance (LI), to predict time to readmission (TTR) a ... Full text Link to item Cite

Association of Visit-to-Visit Variability in Kidney Function and Serum Electrolyte Indexes With Risk of Adverse Clinical Outcomes Among Patients With Heart Failure With Preserved Ejection Fraction.

Journal Article JAMA Cardiol · January 1, 2021 IMPORTANCE: Although kidney dysfunction and abnormalities in serum electrolyte levels are associated with poor clinical outcomes in patients with heart failure with preserved ejection fraction (HFpEF), the association of visit-to-visit variability in such ... Full text Link to item Cite

Extracardiac Abnormalities of Preload Reserve: Mechanisms Underlying Exercise Limitation in Heart Failure with Preserved Ejection Fraction, Autonomic Dysfunction, and Liver Disease.

Journal Article Circ Heart Fail · January 2021 While many of the cardiac limitations to exercise performance are now well-characterized, extracardiac limitations to exercise performance have been less well recognized but are nevertheless important. We propose that abnormalities of cardiac preload reser ... Full text Link to item Cite

Association between Pulmonary Hypertension and Outcomes in Heart-Kidney Transplantation

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2021 Cite

Ultrafiltration in Acute Heart Failure: Implications of Ejection Fraction and Early Response to Treatment From CARRESS-HF.

Journal Article J Am Heart Assoc · December 15, 2020 Background Ultrafiltration is not commonly used because of higher incidence of worsening renal function without improved decongestion. We examined differential outcomes of high versus low fluid removal and preserved versus reduced ejection fraction (EF) in ... Full text Open Access Link to item Cite

Implications for Neuromodulation Therapy to Control Inflammation and Related Organ Dysfunction in COVID-19.

Journal Article J Cardiovasc Transl Res · December 2020 COVID-19 is a syndrome that includes more than just isolated respiratory disease, as severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) also interacts with the cardiovascular, nervous, renal, and immune system at multiple levels, increasing morbid ... Full text Open Access Link to item Cite

In-hospital outcomes after bariatric surgery in patients with heart failure.

Journal Article Am Heart J · December 2020 Based on the largest publicly available all-payer inpatient database in the United States, this study sought to evaluate real-world outcomes after bariatric surgery among patients with heart failure. ... Full text Link to item Cite

Economic Evaluation of Catheter Ablation of Atrial Fibrillation in Patients with Heart Failure With Reduced Ejection Fraction.

Journal Article Circ Cardiovasc Qual Outcomes · December 2020 BACKGROUND: Randomized clinical trials have demonstrated that catheter ablation for atrial fibrillation in patients with heart failure with reduced ejection fraction may improve survival and other cardiovascular outcomes. METHODS: We constructed a decision ... Full text Link to item Cite

Applications of the Multisensor HeartLogic Heart Failure Monitoring Algorithm During the COVID-19 Global Pandemic.

Journal Article JACC Case Rep · November 18, 2020 In the COVID-19 era, the heart failure community has witnessed an unprecedented reduction in heart failure-related patient visits and hospitalizations. Social distancing measures present a dilemma for patients with heart failure who require frequent survei ... Full text Open Access Link to item Cite

Lower Post Myocardial Infarction Mortality Among Women Treated at Veterans Affairs Hospitals Compared to Men.

Journal Article Am J Med Sci · November 2020 BACKGROUND: There is conflicting evidence about whether mortality after myocardial infarction is higher among women than among men. This study aimed to compare sex differences in post myocardial infarction mortality in the Veterans Affairs system, a settin ... Full text Link to item Cite

Characterization of the Progression From Ambulatory to Hospitalized Heart Failure With Preserved Ejection Fraction.

Journal Article J Card Fail · November 2020 BACKGROUND: Heart failure (HF) with preserved ejection fraction (HFpEF) is a heterogeneous syndrome. Some patients develop elevated filling pressures exclusively during exercise and never require hospitalization, whereas others periodically develop congest ... Full text Link to item Cite

Stellate Ganglion Blockade: an Intervention for the Management of Ventricular Arrhythmias.

Journal Article Curr Hypertens Rep · October 23, 2020 PURPOSE OF REVIEW: To highlight the indications, procedural considerations, and data supporting the use of stellate ganglion blockade (SGB) for management of refractory ventricular arrhythmias. RECENT FINDINGS: In patients with refractory ventricular arrhy ... Full text Open Access Link to item Cite

The prognostic value of diastolic and systolic mechanical left ventricular dyssynchrony among patients with coronary artery disease and heart failure.

Journal Article J Nucl Cardiol · October 2020 BACKGROUND: Prevalence and prognostic value of diastolic and systolic dyssynchrony in patients with coronary artery disease (CAD) + heart failure (HF) or CAD alone are not well understood. METHODS: We included patients with gated single-photon emission com ... Full text Link to item Cite

Expected vs Actual Outcomes of Elective Initiation of Inotropic Therapy During Heart Failure Hospitalization.

Journal Article Mayo Clin Proc Innov Qual Outcomes · October 2020 OBJECTIVE: To describe the intent and early outcomes of elective inotrope use during heart failure hospitalization. PATIENTS AND METHODS: A prospective multisite design was used to collect data for hemodynamically stable patients started electively on inot ... Full text Link to item Cite

Splanchnic Nerve Block for Chronic Heart Failure.

Journal Article JACC Heart Fail · September 2020 OBJECTIVES: We hypothesized that splanchnic nerve blockade (SNB) would attenuate increased exercise-induced cardiac filling pressures in patients with chronic HF. BACKGROUND: Chronic heart failure (HF) is characterized by limited exercise capacity driven i ... Full text Link to item Cite

Regional adiposity and heart failure with preserved ejection fraction.

Journal Article Eur J Heart Fail · September 2020 The role of obesity in the pathogenesis of heart failure (HF), and in particular HF with preserved ejection fraction (HFpEF), has drawn significant attention in recent years. The prevalence of both obesity and HFpEF has increased worldwide over the past de ... Full text Link to item Cite

Association of Hypertension and Arterial Blood Pressure on Limb and Cardiovascular Outcomes in Symptomatic Peripheral Artery Disease: The EUCLID Trial.

Journal Article Circ Cardiovasc Qual Outcomes · September 2020 BACKGROUND: Current guidelines recommend aggressive management of hypertension. Recent evidence suggested potential harm with low blood pressure targets in patients with peripheral artery disease. We investigated the association of a history of hypertensio ... Full text Link to item Cite

Correlation of Quantitated Intravascular Volume with Blood Pressure in Patients with Systemic Hypertension.

Journal Article J Cardiovasc Transl Res · August 2020 Volume management is an essential component of anti-hypertensive therapy. Different volume phenotypes have been proposed. We sought to study the total blood volume (TBV), plasma volume (PV), and red blood cell volume (RBV) in hypertensive patients. We incl ... Full text Link to item Cite

Increasing Blood Pressure by Greater Splanchnic Nerve Stimulation: a Feasibility Study.

Journal Article J Cardiovasc Transl Res · August 2020 The splanchnic vascular compartment is the major reservoir for intravascular blood volume, and dysregulation of the compartment was implicated in a series of cardiovascular conditions. We explored feasibility and effectiveness of an implantable cuff system ... Full text Link to item Cite

Renal Outcomes in Patients Bridged to Heart Transplant With a Left Ventricular Assist Device.

Journal Article Ann Thorac Surg · August 2020 BACKGROUND: Patients with end-stage heart failure are increasingly being bridged to heart transplant (BTT) with mechanical circulatory support; however the association between a left ventricular assist device (LVAD) BTT strategy and posttransplant renal ou ... Full text Link to item Cite

A Novel In-hospital Congestion Score to Risk Stratify Patients Admitted for Worsening Heart Failure (from ASCEND-HF).

Journal Article J Cardiovasc Transl Res · August 2020 Patients hospitalized for heart failure (HF) remain at high risk for early readmission. A post hoc analysis was performed of the biomarker substudy of the ASCEND-HF trial. An in-hospital congestion score was derived using orthopnea, pedal edema, and NT-pro ... Full text Link to item Cite

Levels of evidence supporting drug, device, and other recommendations in the American Heart Association/American College of Cardiology guidelines.

Journal Article Am Heart J · August 2020 UNLABELLED: Clinical guideline documents reflect the evidence supporting clinical practice, but few recommendations in cardiovascular guidelines are supported by evidence from randomized controlled trials (RCTs), the highest level of evidence. Incentives f ... Full text Link to item Cite

Addressing Orthostatic Hypotension in Heart Failure: Pathophysiology, Clinical Implications and Perspectives.

Journal Article J Cardiovasc Transl Res · August 2020 Heart failure (HF)is a condition at high risk for orthostatic hypotension (OH)given the large proportion of patients at an advanced age and high burden of comorbidities contributing to OH, as well as a high prevalence of medications with neurovascular and ... Full text Link to item Cite

Reassessing Recipient Mortality Under the New Heart Allocation System: An Updated UNOS Registry Analysis.

Journal Article JACC Heart Fail · July 2020 BACKGROUND: An early report of recipient heart transplantation outcomes under the new U.S. heart allocation system introduced in late 2018 found a lower post-transplant survival rate compared with that of the prior system. OBJECTIVES: The aim of this study ... Full text Link to item Cite

Trends in Treatment for Patients Hospitalized with Heart Failure with Preserved Ejection Fraction Before and After Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT).

Journal Article Am J Cardiol · June 1, 2020 The TOPCAT trial investigated spironolactone vs placebo in patients with heart failure with preserved ejection fraction (HFpEF). Although the primary endpoint was not statistically significant, treatment with spironolactone did reduce heart failure hospita ... Full text Link to item Cite

Periprocedural Risk and Survival Associated With Implantable Cardioverter-Defibrillator Placement in Older Patients With Advanced Heart Failure.

Journal Article JAMA Cardiol · June 1, 2020 IMPORTANCE: Little is known about the utilization rates and outcomes of implantable cardioverter-defibrillator (ICD) and cardiac resynchronization therapy defibrillator (CRT-D) placement among patients with advanced heart failure (HF). OBJECTIVE: To examin ... Full text Link to item Cite

Telehealth transformation: COVID-19 and the rise of virtual care.

Journal Article J Am Med Inform Assoc · June 1, 2020 The novel coronavirus disease-19 (COVID-19) pandemic has altered our economy, society, and healthcare system. While this crisis has presented the U.S. healthcare delivery system with unprecedented challenges, the pandemic has catalyzed rapid adoption of te ... Full text Open Access Link to item Cite

Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial.

Journal Article Lancet · May 2, 2020 BACKGROUND: Catheter-based renal denervation has significantly reduced blood pressure in previous studies. Following a positive pilot trial, the SPYRAL HTN-OFF MED (SPYRAL Pivotal) trial was designed to assess the efficacy of renal denervation in the absen ... Full text Link to item Cite

One-year mortality after implantable cardioverter-defibrillator placement within the Veterans Affairs Health System.

Journal Article Eur J Heart Fail · May 2020 AIMS: Implantable cardioverter-defibrillator (ICD) therapy reduces mortality in patients with heart failure and current guidelines advise implantation of ICDs in patients with a life expectancy of >1 year. We examined trends in all-cause mortality in patie ... Full text Link to item Cite

Future research prioritization in cardiac resynchronization therapy.

Journal Article Am Heart J · May 2020 BACKGROUND: Although cardiac resynchronization therapy (CRT) is effective for some patients with heart failure and a reduced left ventricular ejection fraction (HFrEF), evidence gaps remain for key clinical and policy areas. The objective of the study was ... Full text Link to item Cite

Effects of Liraglutide on Worsening Renal Function Among Patients With Heart Failure With Reduced Ejection Fraction: Insights From the FIGHT Trial.

Journal Article Circ Heart Fail · May 2020 BACKGROUND: The FIGHT (Functional Impact of GLP-1 [glucagon-like peptide-1] for Heart Failure Treatment) trial randomized 300 patients with heart failure with reduced ejection fraction (HFrEF) and a recent hospitalization for heart failure to liraglutide v ... Full text Link to item Cite

Stellate Ganglion Blockade for the Treatment of Refractory Ventricular Arrhythmias.

Journal Article JACC Clin Electrophysiol · May 2020 OBJECTIVES: This study sought to describe our institutional experience with establishing a neurocardiology service in an attempt to provide autonomic modulation as a treatment for ventricular arrhythmias (VAs). BACKGROUND: Treatment-refractory VAs are comm ... Full text Link to item Cite

Moving towards a synchronized left ventricle.

Journal Article J Nucl Cardiol · April 2020 Full text Link to item Cite

Heterogeneous Outcomes of Heart Failure with Better Ejection Fraction.

Journal Article J Cardiovasc Transl Res · April 2020 We evaluated the heterogeneity of outcomes among heart failure patients with ventricular recovery. The BEST trial studied patients with left ventricular ejection fraction (LVEF) ≤ 35%. Serial LVEF assessment was performed at baseline, 3 months, and 12 mont ... Full text Link to item Cite

Impact of Continuous Flow Left Ventricular Assist Device Therapy on Chronic Kidney Disease: A Longitudinal Multicenter Study.

Journal Article J Card Fail · April 2020 BACKGROUND: Many patients undergoing durable left ventricular assist device (LVAD) implantation suffer from chronic kidney disease (CKD). Therefore, we investigated the effect of LVAD support on CKD. METHODS: A retrospective multicenter cohort study, inclu ... Full text Link to item Cite

Heart failure with mid-range ejection fraction: pro and cons of the new classification of Heart Failure by European Society of Cardiology guidelines.

Journal Article ESC Heart Fail · April 2020 Currently, the assessment of left ventricular ejection fraction (LVEF) is the cornerstone of the classification of patients with heart failure (HF). The mid-range LVEF (HFmrEF) category was identified in an attempt to uncover specific characteristics of th ... Full text Link to item Cite

Representativeness of the PIONEER-HF Clinical Trial Population in Patients Hospitalized With Heart Failure and Reduced Ejection Fraction.

Journal Article Circ Heart Fail · April 2020 BACKGROUND: In PIONEER-HF (Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT-pro BNP in Patients Stabilized From an Acute Heart Failure Episode), the in-hospital initiation of sacubitril/valsartan in patients hospitalized for acute decomp ... Full text Link to item Cite

LAWN MOWER VS. LEFT VENTRICULAR ASSIST DEVICE: A CASE OF TRAUMATIC CORONARY INJURY

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 24, 2020 Link to item Cite

Lawn Mower Versus Left Ventricular Assist Device: A Case of Traumatic Coronary Injury.

Journal Article JACC Case Rep · March 2020 A 77-year-old man with history of ischemic cardiomyopathy and left ventricular assist device (LVAD) presented with abdominal pain after a lawn mower accident. Examination and imaging revealed a displaced LVAD driveline and a pericardial hematoma secondary ... Full text Open Access Link to item Cite

Are existing and emerging biomarkers associated with cardiorespiratory fitness in patients with chronic heart failure?

Journal Article Am Heart J · February 2020 BACKGROUND: Cardiorespiratory fitness (CRF) is closely linked to health status and clinical outcomes in heart failure (HF) patients. We aimed to test whether biomarkers can reflect CRF and its change over time. METHODS: This post hoc analysis used data fro ... Full text Link to item Cite

Stress Remains in the Eye of the Beholder.

Journal Article JACC Case Rep · February 2020 Full text Link to item Cite

Association between beta-blocker use and mortality/morbidity in older patients with heart failure with reduced ejection fraction. A propensity score-matched analysis from the Swedish Heart Failure Registry.

Journal Article Eur J Heart Fail · January 2020 BACKGROUND: Beta-blockers reduce mortality and morbidity in heart failure (HF) with reduced ejection fraction (HFrEF). However, patients older than 80 years are poorly represented in randomized controlled trials. We assessed the association between beta-bl ... Full text Link to item Cite

Phrenic Nerve Stimulation for the Treatment of Central Sleep Apnea: A Pooled Cohort Analysis.

Journal Article J Clin Sleep Med · December 15, 2019 STUDY OBJECTIVES: Early evidence with transvenous phrenic nerve stimulation (PNS) demonstrates improved disease severity and quality of life (QOL) in patients with central sleep apnea (CSA). The goal of this analysis is to evaluate the complete prospective ... Full text Link to item Cite

Effect of Once-Weekly Exenatide in Patients With Type 2 Diabetes Mellitus With and Without Heart Failure and Heart Failure-Related Outcomes: Insights From the EXSCEL Trial.

Journal Article Circulation · November 12, 2019 BACKGROUND: Once-weekly exenatide (EQW) had a neutral effect on hospitalization for heart failure (HHF) in the EXSCEL study (Exenatide Study of Cardiovascular Event Lowering), with no differential treatment effect on major adverse cardiac events by baselin ... Full text Link to item Cite

Phrenic Nerve Stimulation for the Treatment of Central Sleep Apnea: A Pooled Cohort Analysis.

Journal Article J Clin Sleep Med · November 5, 2019 STUDY OBJECTIVES: Early evidence with transvenous phrenic nerve stimulation (PNS) demonstrates improved disease severity and quality of life (QOL) in patients with central sleep apnea (CSA). The goal of this analysis is to evaluate the complete prospective ... Link to item Cite

Myocardial Energetics in Heart Failure With Preserved Ejection Fraction.

Journal Article Circ Heart Fail · October 2019 BACKGROUND: The role of coronary microvascular disease and its impact on functional and energetic reserve in heart failure with preserved ejection fraction (HFpEF) remains unclear. We hypothesized that in response to submaximal pharmacologic stress (dobuta ... Full text Link to item Cite

Spironolactone in Acute Heart Failure Patients With Renal Dysfunction and Risk Factors for Diuretic Resistance: From the ATHENA-HF Trial.

Journal Article Can J Cardiol · September 2019 BACKGROUND: Acute heart failure (HF) patients with renal insufficiency and risk factors for diuretic resistance may be most likely to derive incremental improvement in congestion with the addition of spironolactone. METHODS: The Aldosterone Targeted Neuroh ... Full text Link to item Cite

Neuromodulation for the Treatment of Heart Rhythm Disorders.

Journal Article JACC Basic Transl Sci · August 2019 There is an increasing recognition of the importance of interactions between the heart and the autonomic nervous system in the pathophysiology of arrhythmias. These interactions play a role in both the initiation and maintenance of arrhythmias and are impo ... Full text Link to item Cite

The Prognostic Value of Diastolic and Systolic Mechanical Left Ventricular Dyssynchrony Among Patients With Coronary Heart Disease.

Conference JACC Cardiovasc Imaging · July 2019 OBJECTIVES: The goal of this study was to examine whether diastolic dyssynchrony, measured by using gated single-photon emission computed tomography (GSPECT) myocardial perfusion imaging (MPI) in patients with coronary artery disease (CAD), is independentl ... Full text Link to item Cite

Characterization of the Obese Phenotype of Heart Failure With Preserved Ejection Fraction: A RELAX Trial Ancillary Study.

Journal Article Mayo Clin Proc · July 2019 OBJECTIVE: To characterize the obese heart failure with preserved ejection fraction (HFpEF) phenotype in a multicenter cohort. PATIENTS AND METHODS: This was a secondary analysis of the randomized clinical trial RELAX (Phosphodiesterase-5 Inhibition to Imp ... Full text Link to item Cite

Heart Failure and Atrial Fibrillation, Like Fire and Fury.

Journal Article JACC Heart Fail · June 2019 Heart failure and atrial fibrillation are 2 common cardiovascular disorders that frequently complicate one another and exert a significant detrimental effect on cardiovascular health and well-being. Both heart failure and atrial fibrillation continue to in ... Full text Link to item Cite

Efficacy and Safety of Apixaban Versus Warfarin in Patients With Atrial Fibrillation and Extremes in Body Weight.

Journal Article Circulation · May 14, 2019 BACKGROUND: Guidelines caution against the use of non-vitamin K antagonist oral anticoagulants in patients with extremely high (>120 kg) or low (≤60 kg) body weight because of a lack of data in these populations. METHODS: In a post hoc analysis of ARISTOTL ... Full text Link to item Cite

Prognostic value of estimated plasma volume in acute heart failure in three cohort studies.

Journal Article Clin Res Cardiol · May 2019 AIMS: Estimated plasma volume status (ePVS) predicts prognosis in patients with heart failure (HF). It remains unclear whether admission, discharge or change ePVS best predicts post-discharge outcome in patients with acute decompensated heart failure (ADHF ... Full text Link to item Cite

Correction to: Prognostic value of estimated plasma volume in acute heart failure in three cohort studies.

Journal Article Clin Res Cardiol · May 2019 Unfortunately, an error occurred in the methods section of the abstract. ... Full text Link to item Cite

Splanchnic nerve blockade in chronic heart failure (Splanchnic HF-2)

Conference EUROPEAN JOURNAL OF HEART FAILURE · May 1, 2019 Link to item Cite

Identifying responders to oral iron supplementation in heart failure with a reduced ejection fraction: a post-hoc analysis of the IRONOUT-HF trial.

Journal Article J Cardiovasc Med (Hagerstown) · April 2019 BACKGROUND: The IRONOUT-HF trial previously demonstrated that oral iron supplementation minimally increased iron stores and did not improve exercise capacity in patients with heart failure with a reduced ejection fraction (HFrEF) and iron deficiency. METHO ... Full text Link to item Cite

Predictors and Changes in Cardiac Hemodynamics and Geometry With Transcatheter Aortic Valve Implantation.

Journal Article Am J Cardiol · March 1, 2019 The introduction of transcatheter aortic valve implantation (TAVI) has revolutionized the treatment of patients with severe aortic stenosis (AS). However, despite the great clinical success of TAVI, less is known about the cardiac hemodynamics and structur ... Full text Link to item Cite

Relationship of Liver Stiffness With Congestion in Patients Presenting With Acute Decompensated Heart Failure.

Journal Article J Card Fail · March 2019 OBJECTIVE: The significance of liver stiffness (LS) in the setting of cardiovascular congestion during the course of acute decompensated heart failure (ADHF) is under investigation. The aim of this study was to assess LS with the use of transient elastogra ... Full text Link to item Cite

Temporary autonomic modulation with botulinum toxin type A to reduce atrial fibrillation after cardiac surgery.

Journal Article Heart Rhythm · February 2019 BACKGROUND: Postoperative atrial fibrillation (POAF) frequently complicates cardiac surgery and is associated with worse outcomes. The cardiac autonomic nervous system is implicated in the pathogenesis of POAF. OBJECTIVE: The purpose of this study was to d ... Full text Link to item Cite

High-Sensitivity Troponin I in Hospitalized and Ambulatory Patients With Heart Failure With Preserved Ejection Fraction: Insights From the Heart Failure Clinical Research Network.

Conference J Am Heart Assoc · December 18, 2018 Background We sought to study the prevalence of high-sensitivity troponin and its association with cardiac structure and outcomes in ambulatory and hospitalized patients with heart failure with a preserved ejection fraction ( HF p EF ). Methods and Results ... Full text Link to item Cite

Is Time From Last Hospitalization for Heart Failure to Placement of a Primary Prevention Implantable Cardioverter-Defibrillator Associated With Patient Outcomes?

Journal Article Circulation · December 11, 2018 BACKGROUND: Landmark studies have demonstrated the safety and efficacy of implantable cardioverter-defibrillators (ICDs) in selected stable ambulatory patients with heart failure (HF) with a reduced ejection fraction receiving optimal medical therapy. It i ... Full text Link to item Cite

Natural History of Patients Postacute Coronary Syndrome Based on Heart Failure Status.

Journal Article Am J Cardiol · November 1, 2018 The natural history of patients hospitalized for acute coronary syndrome (ACS) with pre-existing versus (vs) de novo heart failure (HF) has not been previously reported over an extended duration of follow-up. The IMPROVE-IT trial enrolled 18,144 patients h ... Full text Link to item Cite

Relation of Volume Overload to Clinical Outcomes in Acute Heart Failure (From ASCEND-HF).

Journal Article Am J Cardiol · November 1, 2018 We aimed to study whether jugular venous distension (JVD) and peripheral edema were associated with worse outcomes in patients with acute heart failure in the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure trial. Of 7,14 ... Full text Link to item Cite

Loop diuretic adjustments in patients with chronic heart failure: Insights from HF-ACTION.

Journal Article Am Heart J · November 2018 BACKGROUND: The relationship between diuretic use or change in diuretic use and outcomes in chronic heart failure (HF) remains poorly defined. We evaluated the association between diuretic use and changes in health status, exercise capacity, and clinical e ... Full text Link to item Cite

New Curveball for Hypertension Guidelines?

Journal Article Circulation · October 23, 2018 Full text Link to item Cite

Prediction of readmissions and mortality in patients with heart failure: lessons from the IMPEDANCE-HF extended trial.

Journal Article ESC Heart Fail · October 2018 AIMS: Readmissions for heart failure (HF) are a major burden. We aimed to assess whether the extent of improvement in pulmonary fluid content (ΔPC) during HF hospitalization evaluated by lung impedance (LI), or indirectly by other clinical and laboratory p ... Full text Link to item Cite

Worsening renal function during decongestion among patients hospitalized for heart failure: Findings from the Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness (ESCAPE) trial.

Journal Article Am Heart J · October 2018 INTRODUCTION: Worsening renal function (WRF) can occur throughout a hospitalization for acute heart failure (HF). However, decongestion can be measured in different ways and the prognostic implications of WRF in the setting of different measures of deconge ... Full text Link to item Cite

Effect on Mortality of Higher Versus Lower β-Blocker (Metoprolol Succinate or Carvedilol) Dose in Patients With Heart Failure.

Journal Article Am J Cardiol · September 15, 2018 This study aimed to compare the effect of β-blocker dose and heart rate (HR) on mortality in patients with heart failure with reduced ejection fraction (HFrEF). The Veteran Affairs databases were queried to identify all patients diagnosed with HFrEF based ... Full text Link to item Cite

Calculated Estimates of Plasma Volume in Patients With Chronic Heart Failure-Comparison With Measured Volumes.

Journal Article J Card Fail · September 2018 BACKGROUND: Calculated estimates of plasma volume (PV) have been developed with the use of hemoglobin/hematocrit-body weight-based methods. The accuracy of such formula-derived values has not been thoroughly evaluated. The objective of this analysis was to ... Full text Link to item Cite

Splanchnic Nerve Block for Acute Heart Failure.

Journal Article Circulation · August 28, 2018 Full text Link to item Cite

Agent Orange exposure in veterans with heart failure

Conference EUROPEAN HEART JOURNAL · August 1, 2018 Link to item Cite

Post-Traumatic Stress Disorder and Heart Failure in Men Within the Veteran Affairs Health System.

Journal Article Am J Cardiol · July 15, 2018 Patients with post-traumatic stress disorder (PTSD) are at risk of multiple co-morbidities and are more likely to develop incident heart failure with reduced ejection fraction (HFrEF). The relation of PTSD with clinical outcomes in HFrEF is not established ... Full text Link to item Cite

The relationship between baseline and follow-up left ventricular ejection fraction with adverse events among primary prevention ICD patients.

Journal Article Am Heart J · July 2018 BACKGROUND: Left ventricular ejection fraction (LVEF) is used to select patients for primary prevention implantable cardioverter defibrillators (ICDs). The relationship between baseline and long-term follow-up LVEF and clinical outcomes among primary preve ... Full text Link to item Cite

Hyperkalemia in Heart Failure: Probably Not O"K".

Journal Article J Am Heart Assoc · May 22, 2018 Full text Link to item Cite

Prevalent digoxin use and subsequent risk of death or hospitalization in ambulatory heart failure patients with a reduced ejection fraction-Findings from the Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) randomized controlled trial.

Journal Article Am Heart J · May 2018 BACKGROUND: Despite more than 200 years of clinical experience and a pivotal trial, recently published research has called into question the safety and efficacy of digoxin therapy in heart failure (HF). METHODS: HF-ACTION (ClinicalTrials.gov Number: NCT000 ... Full text Link to item Cite

Selective vs. Global Renal Denervation: a Case for Less Is More.

Journal Article Curr Hypertens Rep · May 1, 2018 PURPOSE OF REVIEW: Review the renal nerve anatomy and physiology basics and explore the concept of global vs. selective renal denervation (RDN) to uncover some of the fundamental limitations of non-targeted renal nerve ablation and the potential superiorit ... Full text Link to item Cite

Mineralocorticoid Receptor Antagonism in Patients With Atrial Fibrillation: Findings From the ORBIT-AF (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation) Registry.

Journal Article J Am Heart Assoc · April 13, 2018 BACKGROUND: Mineralocorticoid receptor antagonist (MRA) therapy may be beneficial to patients with atrial fibrillation (AF), but little is known about their use in patients with AF and subsequent outcomes. METHODS AND RESULTS: In order to better understand ... Full text Link to item Cite

Aetiology, timing and clinical predictors of early vs. late readmission following index hospitalization for acute heart failure: insights from ASCEND-HF.

Journal Article Eur J Heart Fail · February 2018 AIMS: Patients hospitalized for heart failure (HF) are at high risk for 30-day readmission. This study sought to examine the timings and causes of readmission within 30 days of an HF hospitalization. METHODS AND RESULTS: Timing and cause of readmission in ... Full text Link to item Cite

Orthostatic Hypotension in Patients With Left Ventricular Assist Devices: Acquired Autonomic Dysfunction.

Journal Article ASAIO J · 2018 Contemporary left ventricular assist device (LVAD) technology uses nonphysiologic continuous flow to deliver blood into the circulation. This results in a reduction of pulsatility, which is implicated in some of the commonly associated side effects with LV ... Full text Link to item Cite

Stellate ganglion blockade for the treatment of refractory ventricular arrhythmias: A systematic review and meta-analysis.

Journal Article J Cardiovasc Electrophysiol · December 2017 INTRODUCTION: Treatment refractory ventricular arrhythmias (VAs) are often driven and exacerbated by heightened sympathetic tone. We aim to conduct a systematic review and meta-analysis of published studies of a temporary percutaneous stellate ganglion blo ... Full text Link to item Cite

Electrolyte Derangements in Heart Failure

Conference Journal of Cardiac Failure · August 2017 Full text Cite

Raising the pressure: Hemodynamic effects of splanchnic nerve stimulation.

Journal Article J Appl Physiol (1985) · July 1, 2017 A number of cardiovascular and neurological diseases are characterized by a dysregulation of intravascular volume distribution. The veins and arteries of the visceral organs form the so-called splanchnic vascular compartment and are the largest reservoir f ... Full text Link to item Cite

Trajectory of Congestion Metrics by Ejection Fraction in Patients With Acute Heart Failure (from the Heart Failure Network).

Journal Article Am J Cardiol · July 1, 2017 Differences in the clinical course of congestion by underlying ejection fraction (EF) have not been well-characterized in acute heart failure (AHF). A post hoc analysis was performed using pooled data from the Diuretic Optimization Strategies Evaluation in ... Full text Link to item Cite

The prognostic value of mechanical left ventricular dyssynchrony defined by phase analysis from gated single-photon emission computed tomography myocardial perfusion imaging among patients with coronary heart disease.

Journal Article J Nucl Cardiol · April 2017 BACKGROUND: The prognostic value of left ventricular dyssynchrony measured by gated single-photon emission computed tomography (GSPECT) myocardial perfusion imaging (MPI) and its relationship to electrical dyssynchrony measured by QRS duration are incomple ... Full text Link to item Cite

Autonomic Modulation for the Treatment of Ventricular Arrhythmias: Therapeutic Use of Percutaneous Stellate Ganglion Blocks.

Journal Article J Cardiovasc Electrophysiol · April 2017 Ventricular tachycardia (VT), ventricular fibrillation (VF), and electrical storm are commonly encountered emergency conditions in cardiac and surgical intensive care units. In most cases, recurrent ventricular arrhythmias or electrical storm are associate ... Full text Link to item Cite

Carotid body resection for sympathetic modulation in systolic heart failure: results from first-in-man study.

Journal Article Eur J Heart Fail · March 2017 AIMS: Augmented reflex responses from peripheral chemoreceptors, which are mainly localized in the carotid bodies (CBs), characterize patients with systolic heart failure and contribute to adrenergic hyperactivation. We investigated whether surgical resect ... Full text Link to item Cite

Extracorporeal membrane oxygenation support and post-heart transplant outcomes among United States adults.

Journal Article J Heart Lung Transplant · January 2017 BACKGROUND: Patients supported with extracorporeal membrane oxygenation (ECMO) are given priority listing status for heart transplant (HT). Data on post-HT outcomes for adults with ECMO support at the time of HT are limited. METHODS: We analyzed data from ... Full text Link to item Cite

Body Weight Change During and After Hospitalization for Acute Heart Failure: Patient Characteristics, Markers of Congestion, and Outcomes: Findings From the ASCEND-HF Trial.

Journal Article JACC Heart Fail · January 2017 OBJECTIVES: This study sought to examine the relationships between in-hospital and post-discharge body weight changes and outcomes among patients hospitalized for acute heart failure (AHF). BACKGROUND: Body weight changes during and after hospitalization f ... Full text Link to item Cite

No Time to Waste: in Support of Aggressive and Immediate Management of Hypertension.

Journal Article Curr Hypertens Rep · April 2016 Untreated and uncontrolled hypertension (HTN) presents a major public health burden in the USA and worldwide. Despite the known risk for increased cardiovascular (CV) morbidity and mortality, blood pressure remains untreated and uncontrolled at alarming ra ... Full text Link to item Cite

Data on coronary artery calcium score performance and cardiovascular risk reclassification across gender and ethnicities.

Journal Article Data Brief · March 2016 The current guidelines recommend the new risk score, Atherosclerotic Cardiovascular Disease score (ASCVD), to assess an individual׳s risk of future cardiovascular disease (CVD) events. No data exist on the predictive utility of ASCVD score with the increme ... Full text Link to item Cite

Driveline Infection Risk with Utilization of a Temporary External Anchoring Suture After Implantation of a Left Ventricular Assist Device.

Journal Article ASAIO J · 2016 Driveline infections (DLI) are a cause of morbidity after continuous-flow left ventricular assist device (CF-LVAD) implantation. Because driveline trauma contributes to DLI, we assessed whether intraoperative placement of a temporary external anchoring sut ... Full text Link to item Cite

Vascular Dysfunction in High BMI Black College Football Players

Conference ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY · 2016 Cite

Marginal Donor Use in Patients Undergoing Heart Transplantation With Left Ventricular Assist Device Explantation.

Journal Article Ann Thorac Surg · December 2015 BACKGROUND: The use of continuous flow (CF) left ventricular assist devices (LVAD) as a bridge to orthotopic heart transplantation (OHT) has increased. This study examined survival outcomes after CF-LVAD explantation and OHT using marginal donors. METHODS: ... Full text Link to item Cite

Effects of carotid body tumor resection on the blood pressure of essential hypertensive patients.

Journal Article J Am Soc Hypertens · June 2015 Removal of carotid body (CB) improves animal models of hypertension (HTN) and heart failure, via withdrawal of chemoreflex-induced sympathetic activation. Effect of CB tumor (CBT) resection on blood pressure (BP) in subjects with HTN is unknown. A retrospe ... Full text Link to item Cite

THE METABOLIC SYNDROME, CORONARY ARTERY CALCIUM SCORE AND CARDIOVASCULAR RISK RECLASSIFICATION

Conference Journal of the American College of Cardiology · March 2015 Full text Cite

BR2ACED RISK SCORE A PREDICTOR OF MORTALITY PRIOR TO TAVR

Conference Journal of the American College of Cardiology · March 2015 Full text Cite

ETHNICITY, CORONARY ARTERY CALCIUM SCORE AND CARDIOVASCULAR RISK RECLASSIFICATION

Conference Journal of the American College of Cardiology · March 2015 Full text Cite

GENDER, CORONARY ARTERY CALCIUM SCORE AND CARDIOVASCULAR RISK RECLASSIFICATION

Conference Journal of the American College of Cardiology · March 2015 Full text Cite

CORONARY ARTERY CALCIUM SCORE AND CARDIOVASCULAR RISK RECLASSIFICATION

Conference Journal of the American College of Cardiology · March 2015 Full text Cite

The endpoint on measuring the clinical effects of renal denervation: What are the best surrogates

Chapter · January 1, 2015 In the past several years, renal denervation has proven to be an effective treatment for resistant hypertension (HTN). Unfortunately the procedure does not always lower blood pressure and many patients continue to need drugs for HTN. While there are severa ... Full text Cite

Percutaneous management of RetroFlex 3 balloon rupture and separation of the Edwards Sapien delivery system.

Journal Article Tex Heart Inst J · December 2014 We report the case of an 85-year-old woman with severe aortic stenosis who underwent transcatheter aortic valve replacement with use of the Edwards Sapien(®) valve system. The procedure was complicated by rupture of the valve-deployment balloon, with separ ... Full text Link to item Cite

The thrill of success: central arterial-venous anastomosis for hypertension.

Journal Article Curr Hypertens Rep · December 2014 Excess blood pressure remains the most important risk factor for cardiovascular and renal disease. Poly pharmacy has been proved safe and effective under clinical trial circumstances; however, the majority of patients fail to sustain pharmaceutical persist ... Full text Link to item Cite

Racial differences in the prevalence of severe aortic stenosis.

Journal Article J Am Heart Assoc · May 28, 2014 BACKGROUND: In an era of expanded treatment options for severe aortic stenosis, it is important to understand risk factors for the condition. It has been suggested that severe aortic stenosis is less common in African Americans, but there are limited data ... Full text Link to item Cite

Inflammation in coronary artery disease.

Journal Article Cardiol Rev · 2014 Coronary artery disease (CAD) is the leading cause of death in the United States. Although CAD was formerly considered a lipid accumulation-mediated disease, it has now been clearly shown to involve an ongoing inflammatory response. Advances in basic scien ... Full text Link to item Cite

Carotid body size on CTA: correlation with comorbidities.

Journal Article Clin Radiol · January 2014 AIM: To test the hypothesis that computed tomographic angiography (CTA) can identify carotid body enlargement in patients with sympathetically mediated diseases. MATERIALS AND METHODS: A retrospective chart review of all patients obtaining CTAs of the cerv ... Full text Link to item Cite

Alpha-1 adrenoceptor-angiotensin II type 1 receptor cross-talk and its relevance in clinical medicine.

Journal Article Cardiol Rev · 2014 The two most relevant clinical trials investigating the efficacy of multiple neurohormonal drug combinations in the treatment of chronic congestive heart failure are the Valsartan Heart Failure Trial and the Candesartan in Heart Failure Assessment of Reduc ... Full text Link to item Cite

Transcatheter aortic valve replacement for aortic bioprosthetic valve failure with cardiogenic shock.

Journal Article J Invasive Cardiol · November 2013 Acutely failing bioprosthetic valves represent a clinical emergency and are exceedingly challenging given the paucity of therapeutic options. Oftentimes, these patients are not re-operative candidates due to clinical instability. We present 2 cases of acut ... Link to item Cite

CT angiography in the detection of carotid body enlargement in patients with hypertension and heart failure.

Journal Article Neuroradiology · November 2013 INTRODUCTION: The carotid body (CB) has previously been found to be enlarged and hyperactive in various disease states such as heart failure (HF), hypertension (HTN), and respiratory disease. Evaluation of CB size in these disease states using imaging has ... Full text Link to item Cite

Carotid body removal for treatment of chronic systolic heart failure.

Journal Article Int J Cardiol · October 3, 2013 BACKGROUND: Augmented reflex response from peripheral chemoreceptors characterises chronic heart failure (CHF), contributes to autonomic imbalance and exercise intolerance and predicts poor outcome. METHODS AND RESULTS: We present a case of a 56-year-old m ... Full text Link to item Cite

Clinical predictors and hemodynamic consequences of elevated peripheral chemosensitivity in optimally treated men with chronic systolic heart failure.

Journal Article J Card Fail · June 2013 AIMS: Augmented peripheral chemoreflex response is an important mechanism in the pathophysiology of chronic heart failure (CHF). This study characterizes prevalence and clinical predictors of this phenomenon in optimally managed male CHF patients, and seek ... Full text Link to item Cite

Peripheral vascular complications during transcatheter aortic valve replacement: management and potential role of chronic steroid use.

Journal Article Perspect Vasc Surg Endovasc Ther · December 2012 PURPOSE: To report a case of a major vascular complication during transcatheter aortic valve replacement (TAVR) and the endovascular management thereof. Additionally, we discuss a possible correlation with long-term steroid use. CASE REPORT: A 79-year-old ... Full text Link to item Cite

Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat.

Journal Article J Physiol · September 1, 2012 The peripheral chemoreflex is known to be enhanced in individuals with hypertension. In pre-hypertensive (PH) and adult spontaneously hypertensive rats (SHRs) carotid body type I (glomus) cells exhibit hypersensitivity to chemosensory stimuli and elevated ... Full text Link to item Cite

The neurohormonal network in the RAAS can bend before breaking.

Journal Article Curr Heart Fail Rep · June 2012 The renin-angiotensin-aldosterone system (RAAS) has evolved in humans as one of the main physiological networks by which blood pressure and blood flow to vital organs is maintained. The RAAS has evolved to circumvent life-threatening events such as hemorrh ... Full text Link to item Cite

Pathophysiology and treatment options for cardiac anorexia.

Journal Article Curr Heart Fail Rep · June 2011 The anorexia-cachexia syndrome (ACS) occurs in many chronic illnesses, such as cancer, AIDS, and chronic obstructive pulmonary disease in addition to chronic congestive heart failure (CHF). Comparable to other chronic states, the ACS complicates CHF and im ... Full text Link to item Cite

Reversible cardiomyopathies--a review.

Journal Article Transplant Proc · November 2010 End-stage renal disease, cirrhosis, obesity, tachycardia, and extreme stress have all been shown to result in impaired left ventricular function. It is becoming clear, however, that the cardiomyopathies associated with these states are reversible after res ... Full text Link to item Cite

Acute decompensated heart failure

Chapter · February 10, 2008 The Washington Manual of Critical Care is a concise pocket manual for physicians and nurses. ... Cite

[Prognostic value of liver stiffness in decompensated heart failure: results of prospective observational transient elastography-based study].

Journal Article Kardiologiia OBJECTIVE: There is growing evidence that liver stiffness (LS) in decompensated heart failure (DHF) is related to congestion, however data about its impact on outcomes are limited. The aim of the study was to evaluate associations and long-term prognostic ... Link to item Cite