Scholars@Duke
Maria Angelica Selim

Maria Angelica Selim

Professor of Pathology
Pathology
selim001@mc.duke.edu
Duke Box 3712, Durham, NC 27710
3106 Hosp South, Durham, NC

Selected Publications

Insights into Keratinocyte and Immunologic Landscape in Cutaneous Graft-Versus-Host Disease through Single-Cell Transcriptomics.

Journal Article JID Innov · July 2025 Cutaneous manifestations are the most common presenting sign of chronic graft-versus-host disease (GVHD), and the extent of cutaneous involvement is also highly correlated with prognosis. Very little is understood about the underlying pathogenesis underpin ... Full text Link to item Cite

A Comparative Study Between Copy Number Alterations and PRAME Immunohistochemical Pilot Study in Challenging Melanocytic Lesions.

Journal Article Cancers (Basel) · April 4, 2025 INTRODUCTION: Diagnostic uncertainty for ambiguous lesions that fall on the spectrum between nevi and melanoma remains a significant challenge and can have consequences for patient management. METHODS: This study aimed to compare the diagnostic utility of ... Full text Link to item Cite

Diagnostic challenges in naevoid melanoma: does depth matter?

Journal Article Clin Exp Dermatol · February 24, 2025 Full text Link to item Cite

A Mimicker of Differentiated Vulvar Intraepithelial Neoplasia: Reactive Atypia From Noncompliance With Lichen Sclerosus Therapy.

Journal Article Am J Dermatopathol · August 1, 2024 Differentiated vulvar intraepithelial neoplasia (d-VIN) is an HPV-independent precursor to vulvar squamous cell carcinoma. The histology of d-VIN lesions is difficult to differentiate from that of non-neoplastic epithelial disorders, especially lichen scle ... Full text Link to item Cite

Banff 2022 Vascularized Composite Allotransplantation Meeting Report: Diagnostic criteria for vascular changes.

Journal Article Am J Transplant · May 2024 As more data become available, the Banff 2007 working classification of skin-containing vascularized composite allograft (VCA) pathology is expected to evolve and develop. This report represents the Banff VCA Working Group's consensus on the first revision ... Full text Link to item Cite

Melanin imaging with pump-probe microscopy for diagnosis of metastatic melanoma

Conference 2024 Conference on Lasers and Electro-Optics, CLEO 2024 · January 1, 2024 Melanoma, the most aggressive skin cancer, is responsible for around 10,000 deaths annually.Wearedevelopingadiagnosticbiomarkerbasedonfemtosecondpump-probemicroscopy of melanin, a natural pigment found in most melanoma. ... Cite

Melanin imaging with pump-probe microscopy for diagnosis of metastatic melanoma

Conference 2024 Conference on Lasers and Electro Optics CLEO 2024 · January 1, 2024 Melanoma, the most aggressive skin cancer, is responsible for around 10,000 deaths annually.Wearedevelopingadiagnosticbiomarkerbasedonfemtosecondpump-probemicroscopy of melanin, a natural pigment found in most melanoma. ... Full text Cite

Pediatric Atypical Melanocytic Proliferations: Single-Site Retrospective Cohort Assessment of Treatment and Long-Term Follow-Up.

Journal Article Cancers (Basel) · December 12, 2023 Atypical and malignant cutaneous tumors are understudied in the pediatric population, with limited data on long-term follow-up. This study examines pediatric (0-18 years) atypical melanocytic proliferations over a twenty-year period (January 2002-December2 ... Full text Link to item Cite

Nonsclerotic Lichen Sclerosus: Definition of a Concept and Pathologic Description.

Journal Article Journal of lower genital tract disease · October 2023 ObjectiveNonsclerotic lichen sclerosus (NSLS) refers to the clinicopathologic situation of examination findings consistent with lichen sclerosus (LS) but without dermal sclerosis on microscopy. This review aims to describe the features of NSLS and ... Full text Cite

Onychocytic Matricoma Presenting as Longitudinal Melanonychia in a Skin of Color Patient.

Journal Article Skin Appendage Disord · August 2023 INTRODUCTION: Onychocytic matricoma (OCM) is a benign acanthoma of the nail matrix that presents with longitudinal melanonychia and nail thickening. Only 18 previously reported cases of OCM are in the literature since it was first described in 2012. CASE P ... Full text Link to item Cite

Bilateral eccrine angiomatous hamartomas of the proximal interphalangeal joints.

Journal Article Dermatol Online J · April 15, 2023 Eccrine angiomatous hamartoma is an uncommon, benign clinical entity constituting a nodular proliferation of eccrine glands and vascular structures localized to the dermis that typically present as unilateral, flesh-colored, erythematous, or violaceous pap ... Full text Link to item Cite

Recrudescence of Severe Carbamazepine- Induced DRESS Syndrome after Initiation of Levetiracetam.

Journal Article Skinmed · 2023 Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a potentially fatal cutaneous hypersensitivity reaction commonly precipitated by antiepileptic drugs (AEDs). Cross-reactivity among aromatic AEDs is well-documented, but between arom ... Link to item Cite

The hypereosinophilic syndrome - an unusual cause of myocarditis and cardioembolic strokes.

Journal Article Am J Med Sci · November 2022 Hypereosinophilic syndrome is a rare disorder characterized by excessive peripheral eosinophilia and eosinophil associated end-organ damage. Clinical presentations are heterogenous and can involve skin, pulmonary, cardiac and neurologic dysfunction. Eosino ... Full text Link to item Cite

Multimodality analysis confers a prognostic benefit of a T-cell infiltrated tumor microenvironment and peripheral immune status in patients with melanoma.

Journal Article J Immunother Cancer · September 2022 BACKGROUND: We previously reported results from a phase 1 study testing intratumoral recombinant poliovirus, lerapolturev, in 12 melanoma patients. All 12 patients received anti-PD-1 systemic therapy before lerapolturev, and 11 of these 12 patients also re ... Full text Link to item Cite

Histopathology after lidocaine/prilocaine cream administration for vulvar biopsy.

Journal Article J Cutan Pathol · October 2021 BACKGROUND: Case series have described disruptive histopathologic changes following lidocaine/prilocaine cream anesthetic for biopsies. METHODS: A study of histopathologic changes was performed following a randomized trial comparing topical lidocaine/prilo ... Full text Link to item Cite

Prognostic Roles of BRAF, KIT, NRAS, IGF2R and SF3B1 Mutations in Mucosal Melanomas.

Journal Article Cells · August 27, 2021 BACKGROUND: The prognostic value of commonly recurrent mutations remains unclear in mucosal melanomas. METHODS: Clinicopathologic parameters of 214 cases of mucosal melanomas diagnosed in 1989-2020 in several clinical institutions were analyzed. NRAS, KIT, ... Full text Link to item Cite

Characterization of Sentinel Lymph Node Immune Signatures and Implications for Risk Stratification for Adjuvant Therapy in Melanoma.

Journal Article Ann Surg Oncol · July 2021 BACKGROUND: Although sentinel lymph node (SLN) biopsy is a standard procedure used to identify patients at risk for melanoma recurrence, it fails to risk-stratify certain patients accurately. Because processes in SLNs regulate anti-tumor immune responses, ... Full text Link to item Cite

Cutaneous involvement by T-cell prolymphocytic leukemia presenting as livedoid vasculopathy.

Journal Article J Cutan Pathol · July 2021 T-cell prolymphocytic leukemia (T-PLL) is a rare, aggressive neoplasm derived from post-thymic T-cells. Patients are typically middle aged with a slight male predominance who present with a high white blood cell count, hepatosplenomegaly, lymphadenopathy, ... Full text Link to item Cite

Phase I trial of intratumoral PVSRIPO in patients with unresectable, treatment-refractory melanoma.

Journal Article J Immunother Cancer · April 2021 BACKGROUND: While programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) antagonists have improved the prognosis for many patients with melanoma, around 60% fail therapy. PVSRIPO is a non-neurovirulent rhinovirus:poliovirus chimera th ... Full text Link to item Cite

Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma.

Journal Article Clin Cancer Res · March 1, 2021 PURPOSE: In this prospective trial, we sought to assess the feasibility of concurrent administration of ipilimumab and radiation as adjuvant, neoadjuvant, or definitive therapy in patients with regionally advanced melanoma. PATIENTS AND METHODS: Twenty-fou ... Full text Link to item Cite

Vascularized composite allotransplants as a mechanistic model for allograft rejection - an experimental study.

Journal Article Transpl Int · March 2021 Vascularized composite allotransplants (VCAs) seem to have several unique features of clinical and experimental importance, including uniquely definable lymphatic drainage that can be easily accessed at the level of ipsilateral regional node beds. Thus, VC ... Full text Link to item Cite

Dissecting the immune landscape of tumor draining lymph nodes in melanoma with high-plex spatially resolved protein detection.

Journal Article Cancer Immunol Immunother · February 2021 BACKGROUND: In melanoma patients, microscopic tumor in the sentinel lymph-node biopsy (SLN) increases the risk of distant metastases, but the transition from tumor in the SLN to metastatic disease remains poorly understood. METHODS: Fluorescent staining fo ... Full text Link to item Cite

Vulvar and perineal verrucous changes complicating hidradenitis suppurativa after wide excision: a case and literature review.

Journal Article Dermatol Online J · June 15, 2020 Poorly controlled and long-standing hidradenitis suppurativa (HS) increases the risk of squamous cell carcinoma (SCC). We report a 54-year-old woman with an over 20-year history of HS, who had previously undergone wide perineal excision with secondary inte ... Link to item Cite

Cutaneous metastasis of SMARCA4-deficient thoracic sarcoma: A diagnostic dilemma with therapeutic implications.

Journal Article J Cutan Pathol · June 2020 SMARCA4-deficient thoracic sarcoma (SMARCA4-DTS) is a recently recognized entity with undifferentiated rhabdoid morphology and mutations in the switch/sucrose nonfermenting BRG1-associated factors complex. Patients are typically males in their fifth decade ... Full text Link to item Cite

Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas.

Journal Article Cells · May 5, 2020 INTRODUCTION: Mucosal melanoma is rare and associated with poorer prognosis in comparison to conventional melanoma subtypes. Little is known about the prognostic significance as well as possible associations between PARP1 and immunologic response in mucosa ... Full text Link to item Cite

A case of periostomy intestinal metaplasia without adenomatous or dysplastic changes in an ulcerative colitis patient.

Journal Article Clin Case Rep · March 2020 We strive to educate medical providers of the possibility of cellular transformation occurring as a parastomal complication and to emphasize the importance of close monitoring, as there is a risk, although low, of subsequent malignant transformation. ... Full text Link to item Cite

Inpatient Pediatric Dermatopathology

Chapter · January 1, 2020 Pediatric dermatopathology includes a range of diseases, particularly inflammatory and genodermatosis, that pathologists may not be entirely familiar with. Furthermore, children are not biopsied frequently, and this limits the understanding of the histopat ... Full text Cite

Hospital-Based Dermatopathology: An Illustrated Diagnostic Guide

Book · January 1, 2020 This book provides a concise reference of the histologic and clinical findings of dermatologic conditions encountered in the inpatient setting. The text is divided into twenty chapters. Histopathologic images and corresponding clinical photographs facilita ... Full text Cite

Transplant-Related and Metastatic Malignancies

Chapter · January 1, 2020 The advances in surgical techniques and the introduction of more effective and less toxic immunosuppression regimens have resulted in increased rate of successful transplantation with extended survival of the recipients. Histologic assessment continues to ... Full text Cite

Introduction and Acknowledgments

Journal Article Hospital Based Dermatopathology an Illustrated Diagnostic Guide · January 1, 2020 Cite

Lichenoid and Interface Dermatitis

Chapter · January 1, 2020 A number of uncommon, clinically varied, and sometimes poorly understood inflammatory cutaneous diseases are linked by the presence of histologic findings classified as lichenoid and interface dermatitis. These inflammatory patterns can be seen in potentia ... Full text Cite

Subacute cutaneous lupus erythematosus and dermatomyositis associated with anti-programmed cell death 1 therapy.

Journal Article Br J Dermatol · September 2019 Programmed cell death 1 (PD-1) blockade has rapidly emerged as an effective therapy for a wide variety of metastatic malignancies. It has been associated with multiple immune-related adverse effects, including cutaneous eruptions. We describe two patients ... Full text Link to item Cite

Neutrophilic figurate erythema of infancy: A diagnostic challenge.

Journal Article J Cutan Pathol · March 2019 Neutrophilic figurate erythema of infancy (NFEI) is a rare variant of annular erythema of infancy. It is characterized by annular erythematous plaques, occasionally with a polycyclic configuration. The main challenge is to differentiate this rare entity fr ... Full text Link to item Cite

Resolution of Pembrolizumab-Associated Steroid-Refractory Lichenoid Dermatitis with Cyclosporine.

Journal Article Oncologist · March 2019 Checkpoint inhibitors such as pembrolizumab, an anti-PD-1 monoclonal antibody, are a promising new category of oncological therapeutics, associated with a higher risk of immune-related adverse events including dermatological, autoimmune and endocrine seque ... Full text Link to item Cite

Erythema dyschromicum perstans: A case report and systematic review of histologic presentation and treatment.

Journal Article Int J Womens Dermatol · December 2018 OBJECTIVE: Erythema dyschromicum perstans (EDP) can be difficult to diagnose and treat; therefore, we reviewed the literature to assess whether histology can be used to differentiate lichen planus pigmentosus (LPP) from EDP and determine which treatments a ... Full text Link to item Cite

Nodular amyloidosis in a patient with systemic scleroderma.

Journal Article Dermatol Online J · September 15, 2018 Primary cutaneous amyloidosis may be characterized as macular amyloidosis, lichenoid amyloidosis, or nodular amyloidosis. Nodular amyloidosis results from the deposition of immunoglobulin light chains and may rarely be associated with systemic amyloidosis. ... Open Access Link to item Cite

A Phase I Trial of the IGF-1R Antibody Ganitumab (AMG 479) in Combination with Everolimus (RAD001) and Panitumumab in Patients with Advanced Cancer.

Journal Article Oncologist · July 2018 PURPOSE: This study evaluated the maximum tolerated dose or recommended phase II dose (RPTD) and safety and tolerability of the ganitumab and everolimus doublet regimen followed by the ganitumab, everolimus, and panitumumab triplet regimen. MATERIALS AND M ... Full text Link to item Cite

De novo belatacept in clinical vascularized composite allotransplantation.

Journal Article Am J Transplant · July 2018 Most immunosuppressive regimens used in clinical vascularized composite allotransplantation (VCA) have been calcineurin inhibitor (CNI)-based. As such, most recipients have experienced CNI-related side effects. Costimulation blockade, specifically CD28/B7 ... Full text Link to item Cite

Prognostic role of tumoral PDL1 expression and peritumoral FoxP3+ lymphocytes in vulvar melanomas.

Journal Article Hum Pathol · March 2018 The prognostic role of PDL1 expression, CD8+ and FoxP3+ lymphocytes in vulvar melanomas has not been studied. We correlated PDL1 expression and CD8+ and FoxP3+ immune infiltrates with clinicopathologic variables and patient outcomes in a series of 75 vulva ... Full text Link to item Cite

Chemotherapy-induced eccrine squamous syringometaplasia in an infant.

Journal Article Pediatr Dermatol · January 2018 There are few reports of chemotherapy-induced eccrine squamous syringometaplasia in children. We report the first case of an infant developing this condition after treatment with busulfan, fludarabine, and antithymocyte globulin in preparation for bone mar ... Full text Link to item Cite

KIT mutations and CD117 overexpression are markers of better progression-free survival in vulvar melanomas.

Journal Article Br J Dermatol · November 2017 BACKGROUND: Few studies have addressed prognostic markers and none has correlated molecular status and prognosis in vulvar melanomas. OBJECTIVES: To evaluate the clinicopathological features of 95 cases of vulvar melanoma. METHODS: p53, CD117, Ki-67, neuro ... Full text Link to item Cite

Lichenoid Dermatitis of the Vulva: Diagnosis and Differential Diagnosis for the Gynecologic Pathologist.

Journal Article Adv Anat Pathol · September 2017 Inflammatory processes affecting the vulva may present a unique challenge due to location specific changes. Different factors are behind the intricacy in the presentation of vulvar dermatoses. First, the vulva is lined by different epithelia (hair-bearing ... Full text Link to item Cite

Primary cutaneous aggressive epidermotropic cytotoxic T-cell lymphomas: reappraisal of a provisional entity in the 2016 WHO classification of cutaneous lymphomas.

Journal Article Mod Pathol · May 2017 Primary cutaneous CD8-positive aggressive epidermotropic T-cell lymphoma is a rare and poorly characterized variant of cutaneous lymphoma still considered a provisional entity in the latest 2016 World Health Organization Classification of Cutaneous lymphom ... Full text Link to item Cite

Label-Free Imaging of Female Genital Tract Melanocytic Lesions With Pump-Probe Microscopy: A Promising Diagnostic Tool.

Journal Article J Low Genit Tract Dis · April 2017 OBJECTIVES: Melanomas of the female genital tract present a unique clinical challenge. Not only are these lesions in an anatomically sensitive area, but also they tend to be multifocal and have high recurrence rates. Furthermore, several benign melanocytic ... Full text Link to item Cite

GATA3 and MYB Expression in Cutaneous Adnexal Neoplasms.

Journal Article Am J Dermatopathol · April 2017 Knowledge of staining pattern of certain immunostains might be useful in the classification of cutaneous adnexal tumors that can have clinical importance. We studied GATA3 and MYB expression in archival materials of 220 adnexal tumors comprised of sebaceou ... Full text Link to item Cite

Amicrobial Pustulosis of the Folds and Autoimmunity.

Journal Article J Low Genit Tract Dis · October 2016 Full text Link to item Cite

Ki-67, p53, and p16 expression, and G691S RET polymorphism in desmoplastic melanoma (DM): A clinicopathologic analysis of predictors of outcome.

Journal Article J Am Acad Dermatol · September 2016 BACKGROUND: The prognostic role Ki-67, p53, and p16 immunostains and RET (rearranged during transfection) polymorphism in desmoplastic melanoma has not been evaluated. OBJECTIVE: We sought to identify potential prognostic markers. METHODS: We performed Ki- ... Full text Link to item Cite

Epidermal CYLD inactivation sensitizes mice to the development of sebaceous and basaloid skin tumors.

Journal Article JCI Insight · July 21, 2016 The deubiquitinase-encoding gene Cyld displays a dominant genetic linkage to a wide spectrum of skin-appendage tumors, which could be collectively designated as CYLD mutant-syndrome (CYLDm-syndrome). Despite recent advances, little is understood about the ... Full text Link to item Cite

Cellular Blue Nevomelanocytic Lesions: Analysis of Clinical, Histological, and Outcome Data in 37 Cases.

Journal Article Am J Dermatopathol · July 2016 Cellular blue nevomelanocytic lesions (CBNLs) frequently pose diagnostic problems to pathologists, and their biological potential may be difficult to establish. In this study, the authors have analyzed the clinical, histological, and outcome data of 37 cel ... Full text Link to item Cite

Differentiated Vulvar Intraepithelial Neoplasia: What Criteria Do We Use in Practice?

Journal Article J Low Genit Tract Dis · July 2016 OBJECTIVES: We sought to recognize the working diagnostic criteria for differentiated vulvar intraepithelial neoplasia (dVIN) among expert pathologists in the field. We also sought the frequency of definitive diagnosis, terminology of equivocal lesions, an ... Full text Link to item Cite

Vascularized composite allotransplantation: a closer look at the banff working classification.

Journal Article Transpl Int · June 2016 The first Banff vascularized composite allotransplantation meeting was held in 2007 to standardize criteria for the characterization and reporting of severity and types of rejection. As a result, the 2007 Banff VCA working classification for skin allograft ... Full text Link to item Cite

Subungual leiomyoma in the left thumb of a 16-year-old female.

Journal Article J Cutan Pathol · April 2016 Cutaneous leiomyomata, which are benign smooth muscle neoplasms, commonly present as dermal-based nodules or papules with smooth borders and firm consistency. Digital, particularly subungual leiomyomata are quite rare. A 16-year-old female presented to nai ... Full text Link to item Cite

Biostable electrospun microfibrous scaffolds mitigate hypertrophic scar contraction in an immune-competent murine model.

Journal Article Acta Biomater · March 1, 2016 UNLABELLED: Burn injuries in the United States account for over one million hospital admissions per year, with treatment estimated at four billion dollars. Of severe burn patients, 30-90% will develop hypertrophic scars (HSc). In this study, we evaluate th ... Full text Link to item Cite

Rhabdomyomatous mesenchymal hamartoma presenting as a sacral skin tag in two neonates with spinal dysraphism.

Journal Article J Cutan Pathol · October 2015 Rhabdomyomatous mesenchymal hamartoma (RMH) is a rare congenital malformation involving the dermis and subcutaneous tissue, of which there were 62 reported cases through 2014. We report RMH in two neonates presenting as a sacral skin tag. In both cases, ma ... Full text Link to item Cite

Pump-probe imaging of pigmented cutaneous melanoma primary lesions gives insight into metastatic potential.

Journal Article Biomed Opt Express · September 1, 2015 Metastatic melanoma is associated with a poor prognosis, but no method reliably predicts which melanomas of a given stage will ultimately metastasize and which will not. While sentinel lymph node biopsy (SLNB) has emerged as the most powerful predictor of ... Full text Link to item Cite

Evaluation of burn severity in vivo in a mouse model using spectroscopic optical coherence tomography.

Journal Article Biomed Opt Express · September 1, 2015 Clinical management of burn injuries depends upon an accurate assessment of the depth of the wound. Current diagnostic methods rely primarily on subjective visual inspection, which can produce variable results. In this study, spectroscopic optical coherenc ... Full text Link to item Cite

Sentinel lymph node biopsy following a rotational flap.

Journal Article BMJ Case Rep · July 14, 2015 Sentinel lymph node biopsy (SLNB) is a critical component of melanoma management. Extensive prior surgery at the site of a primary melanoma is considered a relative contraindication for SLNB. While evidence suggests that SLNB may be performed accurately ev ... Full text Link to item Cite

Melanocytic tumors with intraepidermal melanophages: a report of five cases with review of 231 archived cutaneous melanocytic tumors.

Journal Article J Cutan Pathol · June 2015 Dermal melanophages are frequently encountered in both benign melanocytic nevi and malignant melanoma. In contrast, intraepidermal melanophages (IEM) are under-recognized in melanocytic lesions and their biologic significance is not understood. Herein, we ... Full text Link to item Cite

Cutaneous acquired toxoplasmosis in a child: a case report and review of the literature.

Journal Article Am J Dermatopathol · April 2015 Cutaneous toxoplasmosis is a rare and diagnostically challenging entity. Today, the acquired form occurs predominantly in immunocompromised patients with human immunodeficiency virus or after hematopoietic stem cell transplantation. We report a case of cut ... Full text Link to item Cite

Angiotensin II stimulates canonical TGF-β signaling pathway through angiotensin type 1 receptor to induce granulation tissue contraction.

Conference J Mol Med (Berl) · March 2015 UNLABELLED: Hypertrophic scar contraction (HSc) is caused by granulation tissue contraction propagated by myofibroblast and fibroblast migration and contractility. Identifying the stimulants that promote migration and contractility is key to mitigating HSc ... Full text Link to item Cite

Mitigation of hypertrophic scar contraction via an elastomeric biodegradable scaffold.

Journal Article Biomaterials · March 2015 Hypertrophic scar (HSc) occurs in 40-70% of patients treated for third degree burn injuries. Current burn therapies rely upon the use of bioengineered skin equivalents (BSEs), which assist in wound healing but do not prevent HSc contraction. HSc contractio ... Full text Link to item Cite

Evolution of terminology for human-papillomavirus-infection-related vulvar squamous intraepithelial lesions.

Journal Article J Low Genit Tract Dis · January 2015 OBJECTIVE: The aim of this study was to review the nearly 100-year evolution of terminology applicable to oncogenic human papillomavirus (HPV)-related vulvar intraepithelial squamous lesions and present current consensus terminology. METHODS: An extensive ... Full text Link to item Cite

In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography.

Journal Article Opt Lett · October 1, 2014 Spectroscopic analysis of biological tissues can provide insight into changes in structure and function due to disease or injury. Depth-resolved spectroscopic measurements can be implemented for tissue imaging using optical coherence tomography (OCT). Here ... Full text Link to item Cite

The nucleic acid scavenger polyamidoamine third-generation dendrimer inhibits fibroblast activation and granulation tissue contraction.

Journal Article Plast Reconstr Surg · September 2014 BACKGROUND: Pathologic cutaneous scarring affects over 40 million people worldwide and costs billions of dollars annually. Understanding mechanisms of fibroblast activation and granulation tissue contraction is the first step toward preventing pathologic s ... Full text Link to item Cite

Vulvar inflammatory dermatoses: an update and review.

Journal Article Am J Dermatopathol · September 2014 Currently, urogenital complaints are among the most common problems encountered by family practitioners, gynecologists, and dermatologists. In response to the intricacy of vulvar disorders, the International Society for the Study of Vulvovaginal Disease wa ... Full text Link to item Cite

Oncogenic mutations in melanomas and benign melanocytic nevi of the female genital tract.

Journal Article J Am Acad Dermatol · August 2014 BACKGROUND: The genetic heterogeneity of melanomas and melanocytic nevi of the female genital tract is poorly understood. OBJECTIVE: We aim to characterize the frequency of mutations of the following genes: BRAF, NRAS, KIT, GNA11, and GNAQ in female genita ... Full text Link to item Cite

Neoplastic nodular B-cell pattern

Chapter · April 1, 2014 Cutaneous B-cell lymphomas encompass a group of B-cell lymphomas that presents in the skin without evidence of extra-cutaneous disease at the time of initial diagnosis; thus, complete laboratory workup and imaging studies are necessary. In 2005 a new conse ... Full text Cite

A novel immune competent murine hypertrophic scar contracture model: a tool to elucidate disease mechanism and develop new therapies.

Journal Article Wound Repair Regen · 2014 Hypertrophic scar (HSc) contraction following burn injury causes contractures. Contractures are painful and disfiguring. Current therapies are marginally effective. To study pathogenesis and develop new therapies, a murine model is needed. We have created ... Full text Link to item Cite

Vulvar adnexal lesions: a 32-year, single-institution review from Massachusetts General Hospital.

Journal Article Arch Pathol Lab Med · September 2013 CONTEXT: Because the skin and modified mucosal surfaces of the vulvar region contain dense apocrine glands and anogenital mammary-like glands, in addition to eccrine glands and folliculosebaceous units, benign as well as malignant lesions derived from thes ... Full text Link to item Cite

Virulence of endemic nonpigmented northern Australian Staphylococcus aureus clone (clonal complex 75, S. argenteus) is not augmented by staphyloxanthin.

Journal Article J Infect Dis · August 1, 2013 Staphylococcus aureus clonal complex 75 (herein referred to as S. argenteus) lacks the carotenoid pigment operon, crtOPQMN, responsible for production of the putative virulence factor, staphyloxanthin. Although a common cause of community-onset skin infect ... Full text Link to item Cite

Nonlinear microscopy of eumelanin and pheomelanin with subcellular resolution.

Journal Article J Invest Dermatol · July 2013 Pump-probe microscopy nondestructively differentiates eumelanin and pheomelanin and can be used to quantify melanin distributions in thin biopsy slices. Here we have extended that work for imaging eumelanin and pheomelanin distributions on a subcellular sc ... Full text Link to item Cite

TNXB mutations can cause vesicoureteral reflux.

Journal Article J Am Soc Nephrol · July 2013 Primary vesicoureteral reflux (VUR) is the most common congenital anomaly of the kidney and the urinary tract, and it is a major risk factor for pyelonephritic scarring and CKD in children. Although twin studies support the heritability of VUR, specific ge ... Full text Link to item Cite

Melanoma immunotherapy using mature DCs expressing the constitutive proteasome.

Journal Article J Clin Invest · July 2013 BACKGROUND: Many cancers, including melanoma, exclusively express constitutive proteasomes (cPs) and are unable to express immunoproteasomes (iPs). In contrast, mature DCs used for immunotherapy exclusively express iPs. Since proteasomes generate peptides ... Full text Link to item Cite

Frontal fibrosing alopecia: a retrospective review of 19 patients seen at Duke University.

Journal Article J Am Acad Dermatol · May 2013 BACKGROUND: Frontal fibrosing alopecia (FFA) is a type of scarring hair loss primarily observed in postmenopausal women and characterized by fronto-tempero-parietal hairline recession, perifollicular erythema, and loss of eyebrows. The incidence is unknown ... Full text Link to item Cite

Abstract 3914: In vivo label-free examination of early-stage melanoma formation.

Conference Cancer Research · April 15, 2013 AbstractRationale. One of the most lethal forms of skin cancer is the cutaneous melanoma that develops from melanocytes. Distinguishing between benign and malignant pigmented lesions is difficult and often r ... Full text Cite

Vulvar vascular tumors: a clinicopathologic study of 85 patients.

Journal Article Am J Dermatopathol · February 2013 The subepidermal hormonally sensitive tissue of the vulva is anatomically unique and may give rise to a wide variety of vascular tumors. As a consequence, classifying vulvar vascular lesions has been challenging due both to the wide variety of lesions that ... Full text Link to item Cite

Dermatopathology of the foreskin: an institutional experience of over 400 cases.

Journal Article J Cutan Pathol · January 2013 BACKGROUND: Diseases of the foreskin may manifest with an array of pathologic findings, including potentially under-recognized dermatologic conditions. Herein, we summarize an institutional experience in foreskin dermatopathology. METHODS: Diagnoses render ... Full text Link to item Cite

Nonlinear microscopy of eumelanin and pheomelanin with subcellular resolution

Journal Article Journal of Investigative Dermatology · 2013 Pump-probe microscopy nondestructively differentiates eumelanin and pheomelanin and can be used to quantify melanin distributions in thin biopsy slices. Here we have extended that work for imaging eumelanin and pheomelanin distributions on a subcellular sc ... Full text Cite

Pump-probe imaging of melanin identifies metastatic potential of melanoma

Journal Article Frontiers in Optics, FIO 2012 · December 1, 2012 Two-color pump-probe microscopy produces chemical contrast between melanins in skin. Increased eumelanin fraction corresponds with worse melanoma prognosis. The spatial heterogeneity of the melanin fraction, both on a cellular and sub-cellular scale, also ... Cite

A phase I multi-institutional study of systemic sorafenib in conjunction with regional melphalan for in-transit melanoma of the extremity.

Journal Article Ann Surg Oncol · November 2012 BACKGROUND: Isolated limb infusion with melphalan (ILI-M) corrected for ideal body weight (IBW) is a well-tolerated treatment for patients with in-transit extremity melanoma with an approximate 29 % complete response (CR) rate. Sorafenib, a multi-kinase in ... Full text Link to item Cite

Cutaneous γδ T-cell lymphomas: a spectrum of presentations with overlap with other cytotoxic lymphomas.

Journal Article Am J Surg Pathol · November 2012 We reviewed our multicenter experience with gamma-delta (γδ) T-cell lymphomas first presenting in the skin. Fifty-three subjects with a median age of 61 years (range, 25 to 91 y) were diagnosed with this disorder. The median duration of the skin lesions at ... Full text Link to item Cite

Clinicopathologic study of 85 cases of melanoma of the female genitalia.

Journal Article J Am Acad Dermatol · October 2012 BACKGROUND: Melanoma of the female genitalia has poor overall prognosis. OBJECTIVE AND METHODS: To examine prognostic factors influencing survival, the Duke Melanoma and Tumor Registry Databases were queried for patients who had received their clinical car ... Full text Link to item Cite

A multicenter prospective evaluation of the clinical utility of F-18 FDG-PET/CT in patients with AJCC stage IIIB or IIIC extremity melanoma.

Journal Article Ann Surg · August 2012 OBJECTIVE/BACKGROUND: There is a high risk of relapse in stage IIIB/IIIC melanoma. The utility of 2-[fluorine-18]-fluoro-2-deoxy-D-glucose positron emission tomography integrated with computed tomography (FDG-PET/CT) in these patients to evaluate response ... Full text Link to item Cite

An immunohistochemical comparison of cytokeratin 7, cytokeratin 15, cytokeratin 19, CAM 5.2, carcinoembryonic antigen, and nestin in differentiating porocarcinoma from squamous cell carcinoma.

Journal Article Hum Pathol · August 2012 The distinction of porocarcinoma from squamous cell carcinoma is clinically relevant but can often be a diagnostic dilemma. Current markers reported to be helpful in diagnosing porocarcinoma include carcinoembryonic antigen and cytokeratin 7; however, thei ... Full text Link to item Cite

The role of osteopontin and osteopontin aptamer (OPN-R3) in fibroblast activity.

Journal Article J Surg Res · July 2012 BACKGROUND: Scarring is believed to be caused by both persistent inflammation and overexuberant fibroblast activation. Osteopontin (OPN) is a cytokine that promotes cell activation. The absence of OPN in vivo reduces dermal scarring. This suggests that OPN ... Full text Link to item Cite

Fibroblastic rheumatism: a report of 4 cases with potential therapeutic implications.

Journal Article J Am Acad Dermatol · June 2012 BACKGROUND: Fibroblastic rheumatism is a rare dermatoarthropathy characterized by the sudden onset of cutaneous nodules, flexion contractures, and polyarthritis. Histopathology in the correct clinical context confirms the diagnosis. Treatment is based on o ... Full text Link to item Cite

Changes in dermal histomorphology following surgical weight loss versus diet-induced weight loss in the morbidly obese patient.

Journal Article Ann Plast Surg · May 2012 INTRODUCTION: Patients with postgastric bypass and diet-induced weight loss present to the plastic surgeon for various body contouring procedures. Gross differences in skin dermal elasticity may exist between these populations; however, studies evaluating ... Full text Link to item Cite

In vivo pump-probe microscopy of melanoma and pigmented lesions

Journal Article Progress in Biomedical Optics and Imaging Proceedings of SPIE · April 16, 2012 A growing number of dermatologists and pathologists are concerned that the rapidly rising incidence of melanoma reflects not a true 'epidemic' but an increasing tendency to overdiagnose pigmented lesions. Addressing this problem requires both a better unde ... Full text Cite

Abstract 381: Non-invasive histology for early detection of cutaneous melanoma and pigmented lesions in vivo

Journal Article Cancer Research · April 15, 2012 AbstractRationale The diagnosis of melanoma is based on clinical identification followed by histopathologic confirmation. Surgical excision remains the mainstay for a suspicious lesion that will be evaluated ... Full text Cite

In vivo pump-probe microscopy of eumelanin, pheomelanin in melanoma

Journal Article Biomedical Optics Biomed 2012 · January 1, 2012 We employ pump-probe microscopy to highlight eumelanin versus pheomelanin content of pigmented skin lesions in vivo, and combine the technique with confocal reflectance and fluorescence microscopies to gain a more familiar illustration of the skin. © 2012. ... Full text Cite

Pump-probe imaging of melanin identifies metastatic potential of melanoma

Conference Frontiers in Optics Fio 2012 · January 1, 2012 Two-color pump-probe microscopy produces chemical contrast between melanins in skin. Increased eumelanin fraction corresponds with worse melanoma prognosis. The spatial heterogeneity of the melanin fraction, both on a cellular and sub-cellular scale, also ... Full text Cite

Familial eruptive vellus hair cysts.

Journal Article Pediatr Dermatol · 2012 Eruptive vellus hairs cysts are benign papules consisting of small cysts containing multiple vellus hairs. An eruption commonly develops on the chest and sometimes the upper extremities. These papules are asymptomatic or rarely pruritic. Only a few cases o ... Full text Link to item Cite

Apocrine-eccrine carcinomas: molecular and immunohistochemical analyses.

Journal Article PLoS One · 2012 Apocrine-eccrine carcinomas are rare and associated with poor prognosis. Currently there is no uniform treatment guideline. Chemotherapeutic drugs that selectively target cancer-promoting pathways may complement conventional therapeutic approaches. However ... Full text Link to item Cite

Leukocytoclastic vasculitis as the presenting feature of dermatitis herpetiformis.

Journal Article Arch Dermatol · November 2011 BACKGROUND: Dermatitis herpetiformis is an autoimmune disease typically characterized by pruritic vesicles located on the extensor surfaces. Classic disease consists of neutrophils in the dermal papillae. Additional histopathologic findings include fibrin ... Full text Link to item Cite

Validation of a novel rodent model to test anti-scarring therapeutics

Journal Article Wounds · November 1, 2011 Scar contracture is a debilitating disease that affects many people worldwide. There are currently no effective preventative medi-cal treatments. A pivotal step to attaining the goal of developing a treatment is the testing of anti-scarring agents in precl ... Cite

Wound contraction is attenuated by fasudil inhibition of Rho-associated kinase.

Journal Article Plast Reconstr Surg · November 2011 BACKGROUND: Dermal scarring and scar contracture result in restriction of movement. There are no effective drugs to prevent scarring. RhoA and Rho-associated kinase have emerged as regulators of fibrosis and contracture. Fasudil, a Rho-associated kinase in ... Full text Link to item Cite

Changes in oligosaccharide chains of autoantibodies to GRP78 expressed during progression of malignant melanoma stimulate melanoma cell growth and survival.

Journal Article Melanoma Res · August 2011 A correlation between expression of the glucose-regulated protein of 78 kDa (GRP78) in malignant melanoma tumors and poor patient survival is well established. In this study, in addition to demonstrating the expression of GRP78 in tumor tissue, we investig ... Full text Link to item Cite

Vulvar manifestations of Crohn's disease.

Journal Article Am J Dermatopathol · August 2011 Crohn's disease is an inflammatory bowel disorder with several well-known extraintestinal manifestations, such as erythema nodosum, uveitis, and arthritis. Less commonly observed are vulvar manifestations, which have primarily been discussed in case report ... Full text Link to item Cite

Metastatic vs primary malignant neoplasms affecting the umbilicus: clinicopathologic features of 77 tumors.

Journal Article Ann Diagn Pathol · August 2011 Periumbilical skin is unique due to its proximity to intra-abdominal and pelvic structures. In addition to primary skin malignancies, it is a site often involved with metastatic disease. We reviewed the clinical and pathologic features of 77 umbilical mali ... Full text Link to item Cite

A methodology for utilization of predictive genomic signatures in FFPE samples.

Journal Article BMC Med Genomics · July 11, 2011 BACKGROUND: Gene expression signatures developed to measure the activity of oncogenic signaling pathways have been used to dissect the heterogeneity of tumor samples and to predict sensitivity to various cancer drugs that target components of the relevant ... Full text Link to item Cite

Kaposi sarcoma presenting as yellow-green penile plaques in a black man with HIV.

Journal Article Cutis · July 2011 Kaposi sarcoma characteristically presents with violaceous papules, plaques, or nodules due to the vascular nature of the lesions. We present the case of a human immunodeficiency virus (HIV)-positive black man with yellow-green penile plaques. Biopsy resul ... Link to item Cite

Calcium-dependent signaling in Dupuytren's disease.

Journal Article Hand (N Y) · June 2011 BACKGROUND: Previous studies suggest that Dupuytren's disease is caused by fibroblast and myofibroblast contractility. Cell contractility in smooth muscle cells is caused by calcium-dependent and calcium-independent signaling mechanisms. In the calcium-dep ... Full text Link to item Cite

CYLD inhibits tumorigenesis and metastasis by blocking JNK/AP1 signaling at multiple levels.

Journal Article Cancer Prev Res (Phila) · June 2011 CYLD has been recognized as a tumor suppressor due to its dominant genetic linkage to multiple types of epidermal tumors and a range of other cancers. The molecular mechanisms governing CYLD control of skin cancer are still unclear. Here, we showed that K1 ... Full text Link to item Cite

Proliferative nodules arising within congenital melanocytic nevi: a histologic, immunohistochemical, and molecular analyses of 43 cases.

Journal Article Am J Surg Pathol · May 2011 The histopathologic interpretation of proliferative nodules (PNs) in congenital melanocytic nevi can present significant challenges as some PNs may exhibit atypical features that make the distinction from melanoma difficult. We compared histologic features ... Full text Link to item Cite

Temporal spatial expression and function of non-muscle myosin II isoforms IIA and IIB in scar remodeling.

Journal Article Lab Invest · April 2011 Scar contracture is believed to be caused by the cell contractility during the remodeling phase of wound healing. Cell contractility is mediated by non-muscle myosin II (NMMII) and actin, but the temporal-spatial expression profile of NMMII isoforms A and ... Full text Link to item Cite

Atypical vulvar lymphangioma.

Journal Article J Cutan Pathol · March 2011 Full text Link to item Cite

Pump-probe imaging differentiates melanoma from melanocytic nevi.

Journal Article Sci Transl Med · February 23, 2011 Melanoma diagnosis is clinically challenging: the accuracy of visual inspection by dermatologists is highly variable and heavily weighted toward false positives. Even the current gold standard of biopsy results in varying diagnoses among pathologists. We h ... Full text Link to item Cite

Beyond Pathology: Pump-probe imaging of skin slices provides additional indicators of melanoma

Journal Article Optics InfoBase Conference Papers · 2011 Principal component analysis of images taken with a pump-probe scanning microscope resolves eumelanin and pheomelanin. Utilizing intrinsic melanin contrast in skin slices has revealed significant differences between melanoma and other lesions. © 2011 OSA: ... Cite

Beyond Pathology: Pump-probe imaging of skin slices provides additional indicators of melanoma

Conference Optics Infobase Conference Papers · January 1, 2011 Principal component analysis of images taken with a pump-probe scanning microscope resolves eumelanin and pheomelanin. Utilizing intrinsic melanin contrast in skin slices has revealed significant differences between melanoma and other lesions. © 2011 OSA: ... Cite

Angiotensin-II mediates nonmuscle myosin II activation and expression and contributes to human keloid disease progression.

Journal Article Mol Med · 2011 Aberrant fibroblast migration in response to fibrogenic peptides plays a significant role in keloid pathogenesis. Angiotensin II (Ang II) is an octapeptide hormone recently implicated as a mediator of organ fibrosis and cutaneous repair. Ang II promotes ce ... Full text Link to item Cite

Nonlinear high-resolution imaging of eumelanin and pheomelanin distributions in normal skin tissue and melanoma

Journal Article Optics InfoBase Conference Papers · December 1, 2010 Two-color two-photon spectroscopy allows us for the first time to image the distribution of eumelanin and pheomelanin in tissue slices, giving histology-like detail and highlighting chemical and morphological changes in melanoma compared to benign lesions. ... Cite

Neuronal ceroid lipofuscinosis diagnosed via skin biopsy.

Journal Article J Clin Neurosci · December 2010 We aim to report that skin biopsy, a non-invasive test by neurological standards, may lead to a diagnosis. A 4-year-old male presented with a 2-year history of epilepsy and progressive developmental regression. The patient had a mildly elevated ammonia lev ... Full text Link to item Cite

Cutaneous metastatic cholangiocarcinoma: a report of three cases and review of the literature.

Journal Article J Cutan Pathol · December 2010 Cutaneous metastasis from cholangiocarcinoma is an extremely rare event. Herein, we present three cases with review of the literature. Case 1 is that of a young female with scalp metastasis. Cases 2 and 3 involve cutaneous metastasis to the sites of prior ... Full text Link to item Cite

A histologic review of vulvar inflammatory dermatoses and intraepithelial neoplasm.

Journal Article Dermatol Clin · October 2010 Featured Publication Patients with urogenital complaints are frequently encountered by family practitioners, gynecologists, and dermatologists. This review article provides practical information regarding normal anatomy and embryology of the vulva, followed by a summary of pro ... Full text Link to item Cite

Dupuytren's fibroblast contractility by sphingosine-1-phosphate is mediated through non-muscle myosin II.

Journal Article J Hand Surg Am · October 2010 PURPOSE: Previous studies suggest that Dupuytren's disease is caused by fibroblast and myofibroblast contractility within Dupuytren's nodules; however, the stimulus for cell contractility is unknown. Sphingosine-1-phosphate (S1P) is a serum-derived lysopho ... Full text Link to item Cite

Acquired vulvar lymphangioma circumscriptum: a comparison of 12 cases with Crohn's associated lesions or radiation therapy induced tumors.

Journal Article J Cutan Pathol · September 2010 BACKGROUND: Lymphangioma circumscriptum (LC) is a benign lesion of lymphatic origin. Vulvar involvement occurs in various clinical settings. METHODS: We present 12 cases, and compare lesions in patients with Crohn's disease and those associated with pelvic ... Full text Link to item Cite

Inhibition of poly(ADP-ribose) polymerase enhances the effect of chemotherapy in an animal model of regional therapy for the treatment of advanced extremity malignant melanoma.

Journal Article Ann Surg Oncol · August 2010 BACKGROUND: Poly(ADP-ribose) polymerase (PARP) is an important regulator of programmed cell death in response to alkylating agents such as temozolomide (TMZ). The goal of this study was to determine if a systemically administered PARP-inhibitor (INO-1001) ... Full text Link to item Cite

Sorafenib, a multikinase inhibitor, enhances the response of melanoma to regional chemotherapy.

Journal Article Mol Cancer Ther · July 2010 Featured Publication Melanoma responds poorly to standard chemotherapy due to its intrinsic chemoresistance. Multiple genetic and molecular defects, including an activating mutation in the BRaf kinase gene, are associated with melanoma, and the resulting alterations in signal ... Full text Link to item Cite

Alopecia in IL-10-deficient mouse pups is c-kit-dependent and can be triggered by iron deficiency.

Journal Article Exp Dermatol · June 2010 Hair loss (alopecia) can result from a variety of metabolic, endocrine, immunologic, and environmental causes. This investigation was undertaken to determine the mechanisms underlying the sporadic development of alopecia in litters from C57BL/6 interleukin ... Full text Link to item Cite

Isolated and synchronous vulvar granular cell tumors: a clinicopathologic study of 17 cases in 13 patients.

Journal Article Int J Gynecol Pathol · March 2010 Featured Publication Granular cell tumors (GCTs) are benign Schwann cell-derived neoplasms occurring throughout the body. Vulvar GCTs are usually isolated, but occasionally multifocal. On account of their anatomic location, surgical interventions aiming for negative resection ... Full text Link to item Cite

Paget disease of the vulva: a study of 56 cases.

Journal Article Eur J Obstet Gynecol Reprod Biol · March 2010 OBJECTIVE: To resolve controversial issues regarding vulvar Paget disease through analysis of a substantial number of cases. STUDY DESIGN: The medical records and pathology slides of 56 patients with a diagnosis of vulvar Paget disease were reviewed. Possi ... Full text Link to item Cite

Nonlinear high-resolution imaging of eumelanin and pheomelanin distributions in normal skin tissue and melanoma

Conference Optics Infobase Conference Papers · January 1, 2010 Two-color two-photon spectroscopy allows us for the first time to image the distribution of eumelanin and pheomelanin in tissue slices, giving histology-like detail and highlighting chemical and morphological changes in melanoma compared to benign lesions. ... Full text Cite

Immunohistochemistry in the diagnosis of cutaneous neoplasms.

Journal Article Future Oncol · January 2010 Featured Publication In recent years, there has been a significant increase in the number of diagnostic immunohistochemical stains available to pathologists and dermatopathologists. Immunohistochemistry has become an indispensable tool in dermatopathology, not only in diagnosi ... Full text Link to item Cite

Paget disease of the vulva: a histologic study of 56 cases correlating pathologic features and disease course.

Journal Article Int J Gynecol Pathol · January 2010 The Duke experience with 56 vulvar Paget disease patients was analyzed emphasizing pathologic features and controversial issues. Nearly all patients were Caucasian, and their mean age was 69 years. The average length of follow-up was 5.6 years. For each ca ... Full text Link to item Cite

Patterns of GRP78 and MTJ1 expression in primary cutaneous malignant melanoma.

Journal Article Mod Pathol · January 2010 Featured Publication Cell surface expression of glucose-regulated protein 78 (GRP78) occurs in several types of cancer; however, its role in the behavior of primary cutaneous melanoma is not well studied. The association of cell surface GRP78 with other proteins such as MTJ1 s ... Full text Link to item Cite

A phase 1 study of systemic ADH-1 in combination with melphalan via isolated limb infusion in patients with locally advanced in-transit malignant melanoma.

Journal Article Cancer · October 15, 2009 BACKGROUND: Isolated limb infusion with melphalan is a well-tolerated treatment for patients with in-transit extremity melanoma with an approximately 30% complete response (CR) rate. ADH-1 is a cyclic pentapeptide that disrupts N-cadherin adhesion complexe ... Full text Link to item Cite

GRP78: a multifunctional receptor on the cell surface.

Journal Article Antioxid Redox Signal · September 2009 Featured Publication The 78 kDa glucose-regulated protein (GRP78) is an endoplasmic reticulum chaperone, whose function is generally thought to be restricted to controlling the structural maturation of nascent glycoproteins. However, GRP78 also is expressed on the cell surface ... Full text Link to item Cite

Pediatric melanoma: a single-institution experience of 150 patients.

Journal Article J Pediatr Surg · August 2009 Featured Publication PURPOSE: Differentiating pigmented skin lesions from malignant melanoma in the pediatric population has been a challenge. Despite guidelines describing clinical features and histopathologic criteria to distinguish these lesions, misdiagnoses still occur. W ... Full text Link to item Cite

Targeting N-cadherin enhances antitumor activity of cytotoxic therapies in melanoma treatment.

Journal Article Cancer Res · May 15, 2008 Malignant transformation in melanoma is characterized by a phenotype "switch" from E- to N-cadherin, which is associated with increased motility and invasiveness of the tumor and altered signaling, leading to decreased apoptosis. We hypothesized that the n ... Full text Link to item Cite

The cutaneous manifestations of atypical complete DiGeorge syndrome: a histopathologic and immunohistochemical study.

Journal Article J Cutan Pathol · April 2008 Featured Publication DiGeorge syndrome is a congenital anomaly with a constellation of findings that includes thymic hypoplasia. Only a small subset of patients with DiGeorge syndrome has complete athymia, classified as complete DiGeorge anomaly; one third of these patients sh ... Full text Link to item Cite

Keratosis follicularis spinulosa decalvans in a family.

Journal Article J Am Acad Dermatol · March 2008 Keratosis follicularis spinulosa decalvans (KFSD) is a rare condition characterized by diffuse keratosis pilaris with a scarring alopecia of the scalp and associated photophobia, facial erythema, and palmoplantar keratoderma. Although initially described a ... Full text Link to item Cite

Atypical cellular blue nevi (cellular blue nevi with atypical features): lack of consensus for diagnosis and distinction from cellular blue nevi and malignant melanoma ("malignant blue nevus").

Journal Article Am J Surg Pathol · January 2008 The distinction of cellular blue nevi (CBN) with atypical features ["atypical" CBN (ACBN)] from conventional CBN and malignant melanomas related to or derived from CBN remains a difficult problem. Here, we report on the diagnosis of various cellular blue m ... Full text Link to item Cite

Defining regional infusion treatment strategies for extremity melanoma: comparative analysis of melphalan and temozolomide as regional chemotherapeutic agents.

Journal Article Mol Cancer Ther · May 2007 Five different human melanoma xenografts were used in a xenograft model of extremity melanoma to evaluate the variability of tumor response to regionally administered melphalan or temozolomide and to determine if various components of pertinent drug resist ... Full text Link to item Cite

Melanocytic nevi with nonsurgical trauma: a histopathologic study.

Journal Article Am J Dermatopathol · April 2007 Featured Publication There is a belief among dermatopathologists that benign melanocytic nevi (BMN) may display atypical histologic characteristics when traumatized. However, to our knowledge, a systematic study of nonsurgically traumatized melanocytic nevi (TMN) has not been ... Full text Link to item Cite

Self-healing juvenile cutaneous mucinosis: cases highlighting subcutaneous/fascial involvement.

Journal Article J Am Acad Dermatol · December 2006 BACKGROUND: Self-healing juvenile cutaneous mucinosis is a rare disease affecting young people characterized by transient cutaneous lesions and sometimes mild inflammatory symptoms. The deep dermal and subcutaneous features of this disorder have not yet be ... Full text Link to item Cite

Incontinentia pigmenti in a boy with XXY mosaicism detected by fluorescence in situ hybridization.

Journal Article J Am Acad Dermatol · July 2006 We report the case of a male infant with incontinentia pigmenti (MIM 308310) and low-grade XXY mosaicism. Fluorescence in situ hybridization may reveal the underlying genetic alteration in male patients with incontinentia pigmenti and a normal karyotype. ... Full text Link to item Cite

Differential expression of N-cadherin distinguishes a subset of metastasizing desmoplastic melanomas.

Journal Article Hum Pathol · July 2006 Desmoplastic melanoma is a variant of spindle cell melanoma considered at low risk for distant metastases when compared with other forms of melanoma. The emphasis in the differential diagnosis of desmoplastic melanomas has been placed mostly in distinguish ... Full text Link to item Cite

Histopathologic characteristics, recurrence patterns, and survival of 129 patients with desmoplastic melanoma.

Journal Article Ann Surg Oncol · May 2006 BACKGROUND: Desmoplastic melanoma (DM) has been associated with higher local recurrence rates than other types of cutaneous melanoma. Current controversies regarding locoregional treatment strategies warrant further investigation. METHODS: Retrospective re ... Full text Link to item Cite

Basal cell-signet-ring squamous cell carcinoma of the eyelid.

Journal Article Arch Pathol Lab Med · March 2006 A 93-year-old woman developed a mass on her right lower eyelid that was present for more than 6 months but underwent rapid expansion during several weeks prior to her ophthalmological evaluation. Examination revealed an approximately 1.8 cm in diameter, fl ... Full text Link to item Cite

CD10 expression in trichoepithelioma and basal cell carcinoma.

Journal Article J Cutan Pathol · February 2006 BACKGROUND: Trichoepithelioma (TE) is a benign neoplasm that shares both clinical and histologic features with basal cell carcinoma (BCC). However, it is important to distinguish these neoplasms. Limited immunohistochemical stains are available to separate ... Full text Link to item Cite

Diffuse hypopigmented macules.

Journal Article Arch Dermatol · February 2006 Full text Link to item Cite

A prospective clinical and pathological examination of injection site reactions with the HIV-1 fusion inhibitor enfuvirtide.

Journal Article Antivir Ther · 2006 OBJECTIVE: Antiretroviral regimens containing the fusion inhibitor enfuvirtide (ENF) are associated with sustained viral suppression and immunological benefit. However, local injection site reactions (ISR) occur in the majority of patients. The aim of this ... Link to item Cite

Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin.

Journal Article J Invest Dermatol · October 2005 Ferulic acid is a potent ubiquitous plant antioxidant. Its incorporation into a topical solution of 15%l-ascorbic acid and 1%alpha-tocopherol improved chemical stability of the vitamins (C+E) and doubled photoprotection to solar-simulated irradiation of sk ... Full text Link to item Cite

Uveal melanocytomas: genetic comparison with uveal and dermal melanomas.

Journal Article Arch Ophthalmol · March 2005 OBJECTIVE: Melanocytomas of the eye are typically benign tumors that may be associated with nevi and melanomas. In this study, we assessed the genetic data of melanocytomas and compared them with nevi and melanomas of both the eyes and the skin. DESIGN: We ... Full text Link to item Cite

Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis.

Journal Article Mod Pathol · February 2005 A subset of Spitz nevi poses substantial diagnostic difficulty, even among experts, due to its resemblance to malignant melanoma. These lesions are termed atypical Spitz nevi/tumors and there is currently a lack of objective criteria for predicting their b ... Full text Link to item Cite

Evaluation of concurrent and adjuvant carboplatin with radiation therapy for locally advanced cervical cancer.

Journal Article Gynecol Oncol · July 2004 OBJECTIVE: To analyze the toxicity profile and long-term outcomes of patients receiving carboplatin with concurrent radiation for locally advanced cervical cancer. METHODS: A retrospective study was performed to identify patients treated with carboplatin a ... Full text Link to item Cite

Cutaneous findings in patients with pulmonary arterial hypertension receiving long-term epoprostenol therapy.

Journal Article J Am Acad Dermatol · July 2004 Pulmonary arterial hypertension (PAH) is a rare debilitating disease characterized by an increase in pulmonary vascular resistance and progressive right ventricular failure. PAH may be primary or associated with other conditions such as collagen vascular d ... Full text Link to item Cite

Dermatopathologic manifestations of rheumatologic diseases

Journal Article Pathology Case Reviews · January 1, 2004 Full text Cite

Are en face frozen sections accurate for diagnosing margin status in melanocytic lesions?

Journal Article Am J Clin Pathol · August 2003 To assess the diagnostic accuracy of margin evaluation of melanocytic lesions using en face frozen sections compared with standard paraffin-embedded sections, we studied 2 sets of lesions in which en face frozen sections were used for analysis of surgical ... Full text Link to item Cite

UV photoprotection by combination topical antioxidants vitamin C and vitamin E.

Journal Article J Am Acad Dermatol · June 2003 BACKGROUND: Virtually all plants and animals protect themselves from the sun using vitamins C and E. OBJECTIVE: The purpose of this study was to see if a combination of topical vitamins C and E is better for UV protection to skin than an equivalent concent ... Full text Link to item Cite

What is your diagnosis? Lupus profundus.

Journal Article Am J Dermatopathol · December 2002 Link to item Cite

Severe erythroderma as a complication of continuous epoprostenol therapy.

Journal Article Chest · July 2002 Epoprostenol is a vasodilator that is produced by vascular endothelial cells and is currently the "gold standard" therapy for patients with severe primary pulmonary hypertension or pulmonary hypertension secondary to collagen vascular disease. Hypersensiti ... Full text Link to item Cite

CD34 expression in desmoplastic melanoma.

Journal Article J Cutan Pathol · November 2001 BACKGROUND: Primary and metastatic malignant melanoma can simulate various soft tissue tumors, including dermatofibrosarcoma protuberans (DFSP). Expression of CD34, a marker characteristic of DFSP, as well as other spindle cell tumors, has not been previou ... Full text Link to item Cite

Waxy keratoses of childhood in a segmental distribution.

Journal Article Pediatr Dermatol · 2001 Waxy keratoses of childhood is a rare genodermatosis previously noted in both familial and isolated presentations. Three previous cases have been described in which the lesions appeared over the trunk and extremities. We report a case in which the waxy ker ... Full text Link to item Cite

Microscopic localization of calcifications in and around breast carcinoma: a cautionary note for needle core biopsies.

Journal Article Ann Surg · July 1998 OBJECTIVE: To detail the microanatomic localization of microcalcifications (Ca++) occurring in association with breast carcinoma and thereby to determine their reliability as a marker of breast carcinoma in small tissue core biopsies. SUMMARY BACKGROUND DA ... Full text Link to item Cite