Cynthia Ann Toth

Journal Article Ophthalmol Retina · July 2024 OBJECTIVE: To review recent technological advancement in imaging, surgical visualization, robotics technology, and the use of artificial intelligence in surgical vitreoretinal (VR) diseases. BACKGROUND: Technological advancements in imaging enhance both pr ... Full text Link to item Cite

P Score: A Reference Image-Based Clinical Grading Scale for Vascular Change in Retinopathy of Prematurity.

Journal Article Ophthalmology · May 23, 2024 PURPOSE: The International Classification of Retinopathy of Prematurity, Third Edition (ICROP3), acknowledged that plus-like retinopathy of prematurity (ROP) vascular changes occurs along a spectrum. Historically, clinician-experts demonstrate variable agr ... Full text Link to item Cite

Early Single-Examination Optical Coherence Tomography Biomarkers for Treatment-Requiring Retinopathy of Prematurity.

Journal Article Invest Ophthalmol Vis Sci · April 1, 2024 PURPOSE: Optical coherence tomography (OCT) is an emerging adjunct imaging modality to evaluate retinopathy of prematurity (ROP). From an 11-year research database, we identify early OCT biomarkers that predict treatment-requiring ROP (TR-ROP). METHODS: Fo ... Full text Link to item Cite

A pilot optical coherence tomography angiography classification of retinal neovascularization in retinopathy of prematurity.

Journal Article Sci Rep · January 4, 2024 Extraretinal neovascularization is a hallmark of treatment-requiring retinopathy of prematurity (ROP). Optical coherence tomography angiography (OCTA) offers vascular flow and depth information not available from indirect ophthalmoscopy and structural OCT, ... Full text Link to item Cite

Longitudinal Choroidal Development in Preterm Infants.

Journal Article Ophthalmol Sci · 2024 PURPOSE: To characterize changes in subfoveal choroidal thickness in preterm infants from 30 to 60 weeks' postmenstrual age (PMA). DESIGN: The prospective, observational Study of Eye Imaging in Preterm infantS (BabySTEPS) enrolled infants eligible for reti ... Full text Link to item Cite

Intraoperative OCT-Guided Volumetric Measurements of Subretinal Therapy Delivery in Humans

Journal Article Journal of VitreoRetinal Diseases · January 1, 2024 Purpose: To evaluate a recently developed technique using intraoperative optical coherence tomography (OCT) to measure subretinal tissue plasminogen activator (tPA) volumes in patients with submacular hemorrhage secondary to exudative age-related macular d ... Full text Cite

Computer versus human-expert ranking of posterior pole vascular tortuosity and dilation using retinal vessel maps generated from bedside optical coherence tomography: a proof-of-concept study.

Journal Article J AAPOS · December 2023 Semiautomated computer software (ie, ROPtool) can trace and analyze optical coherence tomography (OCT)-generated retinal vessel maps for plus/pre-plus disease with high reliability and accuracy. This proof-of-concept study found that ROPtool can reliably r ... Full text Link to item Cite

Biphasic change in retinal nerve fibre layer thickness from 30 to 60 weeks postmenstrual age in preterm infants.

Journal Article Br J Ophthalmol · November 2023 BACKGROUND/AIMS: The optic nerve development during the critical postnatal weeks of preterm infants is unclear. We aimed to investigate the change of retinal nerve fibre layer (RNFL) in preterm infants. METHODS: We used an investigational handheld optical ... Full text Link to item Cite

A Deep-Learning Algorithm to Predict Short-Term Progression to Geographic Atrophy on Spectral-Domain Optical Coherence Tomography.

Journal Article JAMA Ophthalmol · November 1, 2023 IMPORTANCE: The identification of patients at risk of progressing from intermediate age-related macular degeneration (iAMD) to geographic atrophy (GA) is essential for clinical trials aimed at preventing disease progression. DeepGAze is a fully automated a ... Full text Link to item Cite

Optical Coherence Tomography and Eye Care.

Journal Article N Engl J Med · October 19, 2023 Full text Link to item Cite

MACULAR NEUROVASCULAR ABNORMALITIES IN A CHILD WITH INCONTINENTIA PIGMENTI ON HANDHELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.

Journal Article Retin Cases Brief Rep · September 1, 2023 PURPOSE: To report macular neurovascular abnormalities in a child with incontinentia pigmenti using handheld optical coherence tomography (OCT) and OCT angiography (OCT-A). METHODS: An eye of a child with incontinentia pigmenti enrolled in BabySTEPS was im ... Full text Link to item Cite

Ocular Pigmentation Impact on Retinal Versus Choroidal Optical Coherence Tomography Imaging in Preterm Infants.

Journal Article Transl Vis Sci Technol · July 3, 2023 PURPOSE: To evaluate the association of fundus pigmentation with the visibility of retinal versus choroidal layers on optical coherence tomography (OCT) in preterm infants. METHODS: For infants enrolled in BabySTEPS, ophthalmologists recorded fundus pigmen ... Full text Link to item Cite

NOVEL METHOD FOR VISUALIZING PERIPHERAL RETINAL STRUCTURES WITH MICROSCOPE-INTEGRATED OPTICAL COHERENCE TOMOGRAPHY.

Journal Article Retin Cases Brief Rep · July 1, 2023 BACKGROUND/PURPOSE: Visualization of peripheral retinal structures with optical coherence tomography (OCT) can be challenging but can offer valuable clinical information. We describe a method for intraoperative OCT of the peripheral retina. METHODS: An inv ... Full text Link to item Cite

Methods for real-time feature-guided image fusion of intrasurgical volumetric optical coherence tomography with digital microscopy.

Journal Article Biomed Opt Express · July 1, 2023 4D-microscope-integrated optical coherence tomography (4D-MIOCT) is an emergent multimodal imaging technology in which live volumetric OCT (4D-OCT) is implemented in tandem with standard stereo color microscopy. 4D-OCT provides ophthalmic surgeons with man ... Full text Link to item Cite

Visualization of surgical maneuvers using intraoperative real-time volumetric optical coherence tomography.

Journal Article Biomed Opt Express · July 1, 2023 Ophthalmic microsurgery is traditionally performed using stereomicroscopes and requires visualization and manipulation of sub-millimeter tissue structures with limited contrast. Optical coherence tomography (OCT) is a non-invasive imaging modality that can ... Full text Link to item Cite

Experts discuss the benefits of this new imaging modality, as well as pitfalls to avoid

Journal Article Retina Today · April 1, 2023 Cite

Low-Dose Intravitreal Methotrexate for Proliferative Vitreoretinopathy.

Journal Article Ophthalmic Surg Lasers Imaging Retina · March 2023 BACKGROUND AND OBJECTIVE: Proliferative vitreoretinopathy (PVR) has been mitigated by intravitreal methotrexate (MTX) 400 μg/0.1 mL in several studies. Here, we evaluate the results from a lower dose of MTX, 200 μg/0.05 mL. MATERIALS AND METHODS: We identi ... Full text Link to item Cite

Associations between systemic health and retinal nerve fibre layer thickness in preterm infants at 36 weeks postmenstrual age.

Journal Article Br J Ophthalmol · February 2023 BACKGROUND/AIMS: Neonatal insults from systemic diseases have been implicated in the pathway of impaired neurodevelopment in preterm infants. We aimed to investigate the associations between systemic health factors and retinal nerve fibre layer (RNFL) thic ... Full text Link to item Cite

Quantitative measurements of intraocular structures and microinjection bleb volumes using intraoperative optical coherence tomography.

Journal Article Biomed Opt Express · January 1, 2023 Intraoperative optical coherence tomography (OCT) systems provide high-resolution, real-time visualization and/or guidance of microsurgical procedures. While the use of intraoperative OCT in ophthalmology has significantly improved qualitative visualizatio ... Full text Link to item Cite

Joseph A. Izatt (1962–2024)

Journal Article Nature Photonics · August 2024 Full text Cite

Artificial Intelligence, Digital Imaging, and Robotics Technologies for Surgical Vitreoretinal Diseases.

P Score: A Reference Image-Based Clinical Grading Scale for Vascular Change in Retinopathy of Prematurity.

Early Single-Examination Optical Coherence Tomography Biomarkers for Treatment-Requiring Retinopathy of Prematurity.

A pilot optical coherence tomography angiography classification of retinal neovascularization in retinopathy of prematurity.

Longitudinal Choroidal Development in Preterm Infants.

Intraoperative OCT-Guided Volumetric Measurements of Subretinal Therapy Delivery in Humans

Computer versus human-expert ranking of posterior pole vascular tortuosity and dilation using retinal vessel maps generated from bedside optical coherence tomography: a proof-of-concept study.

Biphasic change in retinal nerve fibre layer thickness from 30 to 60 weeks postmenstrual age in preterm infants.

A Deep-Learning Algorithm to Predict Short-Term Progression to Geographic Atrophy on Spectral-Domain Optical Coherence Tomography.

Optical Coherence Tomography and Eye Care.

Journal Article N Engl J Med · October 19, 2023 Full text Link to item Cite

MACULAR NEUROVASCULAR ABNORMALITIES IN A CHILD WITH INCONTINENTIA PIGMENTI ON HANDHELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.

Ocular Pigmentation Impact on Retinal Versus Choroidal Optical Coherence Tomography Imaging in Preterm Infants.

NOVEL METHOD FOR VISUALIZING PERIPHERAL RETINAL STRUCTURES WITH MICROSCOPE-INTEGRATED OPTICAL COHERENCE TOMOGRAPHY.

Methods for real-time feature-guided image fusion of intrasurgical volumetric optical coherence tomography with digital microscopy.

Visualization of surgical maneuvers using intraoperative real-time volumetric optical coherence tomography.

Experts discuss the benefits of this new imaging modality, as well as pitfalls to avoid

Journal Article Retina Today · April 1, 2023 Cite

Low-Dose Intravitreal Methotrexate for Proliferative Vitreoretinopathy.

Associations between systemic health and retinal nerve fibre layer thickness in preterm infants at 36 weeks postmenstrual age.

Quantitative measurements of intraocular structures and microinjection bleb volumes using intraoperative optical coherence tomography.

VOLUME PROBLEMS

Journal Article Retina Today · January 1, 2023 Cite

Preterm infant retinal OCT markers of perinatal health and retinopathy of prematurity.

Journal Article Front Pediatr · 2023 The increasing survival of preterm infants has led to the importance of improving long-term outcomes associated with preterm birth. Antenatal and perinatal insults not only impact mortality, but also long-term disability. While in the intensive care nurser ... Full text Link to item Cite

Imaging in Pediatric Eyes

Chapter · January 1, 2023 Multimodal imaging in pediatric eyes is useful for the diagnosis, treatment, and monitoring of several disease processes. Imaging in pediatric patients can be challenging to perform in clinic and an exam under anesthesia (EUA) may be required. Coordination ... Full text Cite

Predominantly Persistent Intraretinal Fluid in the Comparison of Age-related Macular Degeneration Treatments Trials.

Journal Article Ophthalmol Retina · September 2022 PURPOSE: To describe predominantly persistent intraretinal fluid (PP-IRF) and its association with visual acuity (VA) and retinal anatomic findings at long-term follow-up in eyes treated with pro re nata (PRN) ranibizumab or bevacizumab for neovascular age ... Full text Link to item Cite

Semi-automated vessel analysis of en face posterior pole vessel maps generated from optical coherence tomography for diagnosis of plus or pre-plus disease.

Journal Article J AAPOS · August 2022 En face retinal vessel maps generated from bedside optical coherence tomography (OCT) can show posterior pole vascular tortuosity and dilation (ie, plus/pre-plus disease). In this proof-of-concept study, we found that ROPtool could trace OCT-generated reti ... Full text Link to item Cite

Artificial Intelligence for Retinopathy of Prematurity: Validation of a Vascular Severity Scale against International Expert Diagnosis.

Journal Article Ophthalmology · July 2022 PURPOSE: To validate a vascular severity score as an appropriate output for artificial intelligence (AI) Software as a Medical Device (SaMD) for retinopathy of prematurity (ROP) through comparison with ordinal disease severity labels for stage and plus dis ... Full text Link to item Cite

Integrated Visualization Highlighting Retinal Changes in Retinopathy of Prematurity From 3-Dimensional Optical Coherence Tomography Data.

Journal Article JAMA Ophthalmol · July 1, 2022 IMPORTANCE: Early diagnosis of plus disease is critical in the management of retinopathy of prematurity (ROP). However, there is substantial interexpert disagreement in the diagnosis of plus disease based on vascular changes alone. Information derived from ... Full text Link to item Cite

Association Between Retinal Microanatomy in Preterm Infants and 9-Month Visual Acuity.

Journal Article JAMA Ophthalmol · July 1, 2022 IMPORTANCE: Preterm infants are at risk for poor visual acuity (VA) outcomes, even without retinal problems on ophthalmoscopy. Infant retinal microanatomy may provide insight as to potential causes. OBJECTIVE: To evaluate the association between preterm in ... Full text Link to item Cite

Retinopathy of prematurity classification updates: possible implications for treatment.

Journal Article J AAPOS · June 2022 Full text Link to item Cite

Machine learning OCT predictors of progression from intermediate age-related macular degeneration to geographic atrophy and vision loss.

Journal Article Ophthalmol Sci · June 2022 OBJECTIVE: To describe optical coherence tomography (SD-OCT) features, age, gender, and systemic variables that may be used in machine/deep learning studies to identify high-risk patient subpopulations with high risk of progression to geographic atrophy (G ... Full text Link to item Cite

INTERMEDIATE UVEITIS WITH RETINAL DETACHMENT IN A PATIENT WITH POMPE DISEASE.

Journal Article Retin Cases Brief Rep · May 1, 2022 PURPOSE: To describe the ocular findings in a patient with glycogen storage disease II (Pompe disease). METHODS: Case report. RESULTS: A 14-year-old boy with Pompe disease was referred for evaluation of a retinal detachment in the left eye. Indirect ophtha ... Full text Link to item Cite

OCULAR MANIFESTATIONS OF PORETTI-BOLTSHAUSER SYNDROME: FINDINGS FROM MULTIMODAL IMAGING AND ELECTROPHYSIOLOGY.

Journal Article Retin Cases Brief Rep · May 1, 2022 BACKGROUND/PURPOSE: Poretti-Boltshauser syndrome is a rare, nonprogressive neurologic syndrome with characteristic cerebellar cysts on neuroimaging due to mutations in LAMA1. The ophthalmic findings in Poretti-Boltshauser syndrome are not well described. H ... Full text Link to item Cite

Natural history of central sparing in geographic atrophy secondary to non-exudative age-related macular degeneration.

Journal Article Br J Ophthalmol · May 2022 BACKGROUND: The macular central 1 mm diameter zone is crucial to patients' visual acuity, but the long-term natural history of central sparing in eyes with geographic atrophy (GA) is unknown. METHODS: We manually segmented GA in 210 eyes with GA involving ... Full text Link to item Cite

MULTIMODAL ASSESSMENTS OF DRUSENOID PIGMENT EPITHELIAL DETACHMENTS IN THE AGE-RELATED EYE DISEASE STUDY 2 ANCILLARY SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY STUDY COHORT.

Journal Article Retina · May 1, 2022 PURPOSE: To identify features correlating with drusenoid pigment epithelial detachment (DPED) progression in the Age-Related Eye Disease Study 2 Ancillary spectral-domain optical coherence tomography study cohort. METHODS: In this retrospective analysis of ... Full text Link to item Cite

Proliferative Vitreoretinopathy

Chapter · January 1, 2022 Proliferative vitreoretinopathy (PVR) is a clinical syndrome associated with proliferation of cells in the vitreous cavity and on the retinal surface leading to tractional forces on the retina. PVR is the most common cause of re-detachment after retinal de ... Full text Cite

Predominantly Persistent Subretinal Fluid in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal Article Ophthalmol Retina · October 2021 OBJECTIVE: To describe predominantly persistent subretinal fluid (SRF) in eyes receiving ranibizumab or bevacizumab for neovascular age-related macular degeneration and to compare visual acuity (VA) to eyes with nonpersistent SRF. DESIGN: Cohort within ran ... Full text Link to item Cite

International Classification of Retinopathy of Prematurity, Third Edition.

Journal Article Ophthalmology · October 2021 PURPOSE: The International Classification of Retinopathy of Prematurity is a consensus statement that creates a standard nomenclature for classification of retinopathy of prematurity (ROP). It was initially published in 1984, expanded in 1987, and revisite ... Full text Link to item Cite

Evaluating the association of clinical factors and optical coherence tomography retinal imaging with axial length and axial length growth among preterm infants.

Journal Article Graefes Arch Clin Exp Ophthalmol · September 2021 PURPOSE: To study the association of clinical factors and optical coherence tomography (OCT) retinal imaging with axial length (AL) and AL growth in preterm infants METHODS: Among a subgroup of infants from the prospective BabySTEPS study who were screened ... Full text Link to item Cite

Depth-Resolved Visualization of Perifoveal Retinal Vasculature in Preterm Infants Using Handheld Optical Coherence Tomography Angiography.

Journal Article Transl Vis Sci Technol · August 2, 2021 PURPOSE: To establish methods to visualize depth-resolved perifoveal retinal vasculature in preterm infants using handheld optical coherence tomography angiography (OCT-A). METHODS: In this exploratory study, eyes of preterm infants were imaged using an in ... Full text Link to item Cite

Relationship of Topographic Distribution of Geographic Atrophy to Visual Acuity in Nonexudative Age-Related Macular Degeneration.

Journal Article Ophthalmol Retina · August 2021 PURPOSE: To investigate the topographic distribution of geographic atrophy (GA) and to identify an anatomic endpoint that correlates with visual acuity (VA) in eyes with GA. DESIGN: Retrospective analysis of a multicenter, prospective, randomized controlle ... Full text Link to item Cite

Macular OCT Characteristics at 36 Weeks' Postmenstrual Age in Infants Examined for Retinopathy of Prematurity.

Journal Article Ophthalmol Retina · June 2021 PURPOSE: To report our ability to capture,-grade reliably, and analyze bedside macular OCT images from preterm infants and relate OCT findings to biological factors and retinopathy of prematurity (ROP) status at a single time window in the Study of Eye Ima ... Full text Link to item Cite

Microscope-Integrated OCT-Guided Volumetric Measurements of Subretinal Blebs Created by a Suprachoroidal Approach.

Journal Article Transl Vis Sci Technol · June 1, 2021 PURPOSE: To investigate the use of imaging modalities in the volumetric measurement of the subretinal space and examine the volume of subretinal blebs created by a subretinal drug delivery device utilizing microscope-integrated optical coherence tomography ... Full text Link to item Cite

Systemic Factors Associated with a Thinner Choroid in Preterm Infants.

Journal Article Ophthalmol Sci · June 2021 PURPOSE: To identify systemic health factors associated with a thinner choroid, which has been hypothesized as a cause of poor visual outcomes in low-birth weight infants. DESIGN: The prospective, observational Study of Eye Imaging in Preterm Infants (Baby ... Full text Link to item Cite

Local Anatomic Precursors to New-Onset Geographic Atrophy in Age-Related Macular Degeneration as Defined on OCT.

Journal Article Ophthalmol Retina · May 2021 PURPOSE: In macula-wide analyses, spectral-domain (SD) optical coherence tomography (OCT) features including drusen volume, hyperreflective foci, and OCT-reflective drusen substructures independently predict geographic atrophy (GA) onset secondary to age-r ... Full text Link to item Cite

Preterm Infant Stress During Handheld Optical Coherence Tomography vs Binocular Indirect Ophthalmoscopy Examination for Retinopathy of Prematurity.

Journal Article JAMA Ophthalmol · May 1, 2021 IMPORTANCE: Binocular indirect ophthalmoscopy (BIO) examination for retinopathy of prematurity (ROP) is a well-known cause of repeated preterm infant stress. OBJECTIVE: To compare stress during investigational optical coherence tomography (OCT) imaging to ... Full text Link to item Cite

COMBINED INTERNAL LIMITING MEMBRANE FLAP AND AUTOLOGOUS PLASMA CONCENTRATE TO CLOSE A LARGE TRAUMATIC MACULAR HOLE IN A PEDIATRIC PATIENT.

Journal Article Retin Cases Brief Rep · March 1, 2021 PURPOSE: To describe a case of a large, traumatic macular hole in a pediatric patient closed using an internal limiting membrane flap in combination with autologous plasma concentrate (APC). METHODS: Description of a surgical technique as performed in one ... Full text Link to item Cite

Localized Optical Coherence Tomography Precursors of Macular Atrophy and Fibrotic Scar in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal Article Am J Ophthalmol · March 2021 PURPOSE: To identify precursors of macular atrophy (MA) and of fibrotic scar (FS) in eyes treated with anti-vascular endothelial growth factor through pixel-mapping analysis of baseline optical coherence tomography (OCT). METHODS: Design: Cross-sectional a ... Full text Link to item Cite

Birth Weight Is a Significant Predictor of Retinal Nerve Fiber Layer Thickness at 36 Weeks Postmenstrual Age in Preterm Infants.

Journal Article Am J Ophthalmol · February 2021 PURPOSE: To assess retinal nerve fiber layer (RNFL) thickness in preterm infants. DESIGN: Prospective observational study. METHODS: We imaged 83 awake infants (159 eyes) at 36 ± 1 weeks postmenstrual age (defined as the time elapsed between the first day o ... Full text Link to item Cite

Foveal Differentiation and Inner Retinal Displacement Are Arrested in Extremely Premature Infants.

Journal Article Invest Ophthalmol Vis Sci · February 1, 2021 PURPOSE: Children with a history of prematurity often have poorly developed foveae but when during development foveal differences arise. We hypothesize that the course of foveal development is altered from the time of preterm birth. METHODS: Eyes of 102 pr ... Full text Link to item Cite

Lightweight Learning-Based Automatic Segmentation of Subretinal Blebs on Microscope-Integrated Optical Coherence Tomography Images.

Journal Article Am J Ophthalmol · January 2021 PURPOSE: Subretinal injections of therapeutics are commonly used to treat ocular diseases. Accurate dosing of therapeutics at target locations is crucial but difficult to achieve using subretinal injections due to leakage, and there is no method available ... Full text Link to item Cite

Visualizing Three-Layered Perifoveal Retinal Vasculature in Preterm Infants Using Handheld Optical Coherence Tomography Angiography

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2021 Cite

Association between maternal and perinatal systemic factors and macular optical coherence tomography characteristics in preterm infants at 36 weeks postmenstrual age

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2021 Cite

Sepsis and Necrotizing Enterocolitis are Associated with Thinner Retinal Nerve Fiber Layer in Preterm Infants at 36 Weeks Postmenstrual Age

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2021 Cite

Association between retinal microanatomy at 36 weeks postmenstrual age and grating acuity at 9 months in preterm infants

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2021 Cite

Heads-up ocular microsurgery with integrated live volumetric intraoperative optical coherence tomography

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2021 Cite

Ex vivo evaluation of the peripheral retina utilizing a mirrored contact with optical coherence tomography

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2021 Cite

Preoperative Imaging and Surgical Outcomes After Epiretinal Membrane Peeling in Pediatric Combined Hamartoma of the Retina and Retinal Pigment Epithelium

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2021 Cite

Feature-Guided Image Fusion of Intrasurgical Optical Coherence Tomography and Digital Surgical Microscopy

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2021 Cite

An Evaluation of the Microvasculature of Macular Nodules in Coats Disease Using Optical Coherence Tomography Angiography: A Report of 3 Cases.

Journal Article J Vitreoretin Dis · 2021 PURPOSE: This work aimed to examine the microvasculature of macular fibrosis in Coats disease. METHODS: Three boys (aged 3, 4, and 6 years) with Coats disease (stages 2B to 3A2) and macular fibrotic nodules were imaged using optical coherence tomography an ... Full text Link to item Cite

HANDHELD SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY FINDINGS OF X-LINKED RETINOSCHISIS IN EARLY CHILDHOOD.

Journal Article Retina · October 2020 BACKGROUND/PURPOSE: Using handheld spectral domain optical coherence tomography (SDOCT) imaging to investigate in vivo microanatomic retinal changes and their progression over time in young children with juvenile X-linked retinoschisis (XLRS). METHODS: Thi ... Full text Link to item Cite

Morphological characteristics of early- versus late-onset macular edema in preterm infants.

Journal Article J AAPOS · October 2020 Macular images of infants with early-onset edema (occurring at or before 33 weeks' postmenstrual age [PMA]) and infants with late-onset edema (at or after 36 weeks' PMA) were compared. At first appearance, early-onset edema has a more severe morphology, wi ... Full text Link to item Cite

Slow progressive perifoveal vascular formation in an infant with aggressive posterior retinopathy of prematurity.

Journal Article Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · October 2020 Aggressive posterior retinopathy of prematurity (AP-ROP) is a severe form of ROP occurring in preterm infants that is characterized by rapid progression and prominent vascularity. We report the use of investigational bedside noninvasive optical coherence t ... Full text Cite

Repeatability and Reproducibility of Axial and Lateral Measurements on Handheld Optical Coherence Tomography Systems Compared with Tabletop System.

Journal Article Transl Vis Sci Technol · October 2020 PURPOSE: To compare the repeatability and reproducibility of axial and lateral retinal measurements using handheld optical coherence tomography (OCT) systems and a tabletop OCT system. METHODS: Graders measured central foveal thickness (CFT), optic nerve-t ... Full text Link to item Cite

Subclinical Retinal versus Brain Findings in Infants with Hypoxic Ischemic Encephalopathy.

Journal Article Graefes Arch Clin Exp Ophthalmol · September 2020 PURPOSE: To detect retinal features and abnormalities on optical coherence tomography (OCT) without pupil dilation and relate these to brain injury in infants with a clinical diagnosis of hypoxic ischemic encephalopathy (HIE). METHODS: Under an institution ... Full text Link to item Cite

BASELINE CHARACTERISTICS OF VITREOMACULAR TRACTION PROGRESSING TO FULL-THICKNESS MACULAR OR LAMELLAR HOLES IN THE PHASE III TRIALS OF ENZYMATIC VITREOLYSIS.

Conference Retina · August 2020 PURPOSE: To identify characteristics associated with progression from vitreomacular traction (VMT) to a full-thickness macular hole (FTMH) or lamellar hole (LH). METHODS: Post-hoc analysis of the Phase III clinical trial comparing ocriplasmin with placebo ... Full text Link to item Cite

Aphakic contact lens use for improved handheld optical coherence tomography imaging in pediatric aphakic patients.

Journal Article J AAPOS · August 2020 Handheld optical coherence tomography (OCT) makes it possible to acquire intraoperative and clinical imaging in infants and children for whom standard OCT is not possible. In patients with a retinal pathology who are left aphakic after surgery, however, im ... Full text Link to item Cite

Auto-Processed Retinal Vessel Shadow View Images From Bedside Optical Coherence Tomography to Evaluate Plus Disease in Retinopathy of Prematurity.

Journal Article Transl Vis Sci Technol · August 2020 PURPOSE: To describe the creation of en face retinal vessel shadow view (RVSV) optical coherence tomography (OCT) images and assess the feasibility of using these for evaluating vascular disease in preterm infants at risk for retinopathy of prematurity (RO ... Full text Link to item Cite

Comparison of retinal layer thickness measurements from automated segmentation versus with manual correction for optical coherence tomography (OCT) at the fovea in preterm infants in the BabySTEPS study

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 2020 Link to item Cite

Incidence and Progression of Nongeographic Atrophy in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) Clinical Trial.

Journal Article JAMA Ophthalmol · May 1, 2020 IMPORTANCE: Retinal hypopigmentation and hyperpigmentation are precursors of geographic atrophy (GA). Incidence and progression to GA in eyes treated with anti-vascular endothelial growth factor for neovascular age-related macular degeneration (nAMD) have ... Full text Link to item Cite

Ranibizumab and Bevacizumab for Treatment of Neovascular Age-related Macular Degeneration: Two-Year Results.

Journal Article Ophthalmology · April 2020 OBJECTIVE: To describe effects of ranibizumab and bevacizumab when administered monthly or as needed for 2 years and to describe the impact of switching to as-needed treatment after 1 year of monthly treatment. DESIGN: Multicenter, randomized clinical tria ... Full text Link to item Cite

Characteristics of Eyes With Good Visual Acuity at 5 Years After Initiation of Treatment for Age-Related Macular Degeneration but Not Receiving Treatment From Years 3 to 5: Post Hoc Analysis of the CATT Randomized Clinical Trial.

Journal Article JAMA Ophthalmol · March 1, 2020 IMPORTANCE: Identifying the characteristics of eyes with neovascular age-related macular degeneration (nAMD) that maintain good vision without anti-vascular endothelial growth factor treatment for at least 3 years after management, as occurred in the Compa ... Full text Link to item Cite

Differentiating Retinal Detachment and Retinoschisis Using Handheld Optical Coherence Tomography in Stage 4 Retinopathy of Prematurity.

Conference JAMA Ophthalmol · January 1, 2020 IMPORTANCE: Progression of retinopathy of prematurity (ROP) to stage 4 may require surgical intervention. The partial retinal detachment of stage 4 ROP may involve the fovea (stage 4B ROP) or may not (stage 4A ROP). This determination has heretofore been b ... Full text Link to item Cite

Appearance of pediatric choroidal neovascular membranes on optical coherence tomography angiography.

Journal Article Graefes Arch Clin Exp Ophthalmol · January 2020 PURPOSE: Compared with fluorescein angiography (FA), the gold standard for diagnosing choroidal neovascularization (CNV) activity, optical coherence tomography angiography (OCTA) is non-invasive without risks associated with fluorescein dye use, and may be ... Full text Link to item Cite

Comparison of retinal layer thickness measurements from automated segmentation versus with manual correction for optical coherence tomography (OCT) at the fovea in preterm infants in the BabySTEPS study

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

Achievements and need for technologies to advance image-guided retinal surgery and the care of retinal diseases in children

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2020 Through biomedical engineering partnerships, our group has been able to develop and translate optical coherence tomography (OCT), an imaging tool conventionally used in the "eye imaging suite", for bedside use in unstable infants or for intraoperative guid ... Full text Cite

High Speed Volumetric Intrasurgical Optical Coherence Tomography at 400 kHz with Real Time, 4D Visualization of Surgical Maneuvers

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

Use of automated processing of en face swept-source optical coherence tomography images to evaluate vascular disease severity in retinopathy of prematurity

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

Handheld Optical Coherence Tomography Angiography Findings in Preterm Infants with Retinopathy of Prematurity

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

Imaging retinal neovascularization with handheld optical coherence tomography angiography in preterm infants with retinopathy of prematurity

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

Comparing en face swept-source optical coherence tomography images to RetCam photographs in the assessment of retinopathy of prematurity

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

Longitudinal evaluation of visual function in early and intermediate dry age-related macular degeneration over 24 months

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

Optimizing Subretinal Gene Therapy Delivery with Microscope-Integrated Optical Coherence Tomography and Novel Suprachoroidal Delivery System

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

Feasibility to capture retinal microanatomy in novel handheld swept source optical coherence tomography imaging systems in non-sedated preterm infants in the intensive care nursery

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

Repeatability and reproducibility of axial and lateral measurements on handheld optical coherence tomography systems

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

Optical Coherence Tomography (OCT) Characteristics and Prevalence at 35-37 weeks Postmenstrual Age in a Cohort of Very Preterm Infants

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

Preterm infant retinal microanatomy from bedside optical coherence tomography imaging relative to injury score on brain MRI

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

Optical modelling and image dewarping procedures for quantitative measurements of subretinal microinjection volumes using intraoperative OCT

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

Measuring Volume of Subretinal Injections with Commercial Intraoperative OCT

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

Assessment of Macular Microvasculature in Healthy Eyes of Infants and Children Using OCT Angiography.

Journal Article Ophthalmology · December 2019 PURPOSE: To assess macular vasculature in healthy infants and children using OCT angiography (OCTA). DESIGN: Prospective cross-sectional study. PARTICIPANTS: One hundred thirty-five normal maculae of 89 healthy infants and children (mean age, 8.5±5.3 years ... Full text Open Access Link to item Cite

Microvascular Features of Treated Retinoblastoma Tumors in Children Assessed Using OCTA.

Journal Article Ophthalmic Surg Lasers Imaging Retina · December 1, 2019 BACKGROUND AND OBJECTIVE: To describe the microvascular features of treated, clinically regressed, or reactivated retinoblastoma lesions using an investigational portable optical coherence tomography angiography (OCTA) system. PATIENTS AND METHODS: Single- ... Full text Link to item Cite

Handheld Optical Coherence Tomography Normative Inner Retinal Layer Measurements for Children <5 Years of Age.

Journal Article Am J Ophthalmol · November 2019 PURPOSE: Measurements of the ganglion cell complex (GCC), comprising the retinal nerve fiber (RNFL), ganglion cell, and inner plexiform layers, can be correlated with vision loss caused by optic nerve disease. Handheld optical coherence tomography (HH-OCT) ... Full text Link to item Cite

Association Between Cilioretinal Arteries and Advanced Age-Related Macular Degeneration: Secondary Analysis of the Comparison of Age-Related Macular Degeneration Treatment Trials (CATT).

Journal Article JAMA Ophthalmol · November 1, 2019 IMPORTANCE: Recent reports suggest that cilioretinal arteries (CRAs) confer protection against developing advanced age-related macular degeneration (AMD). OBJECTIVE: To further characterize the association between the presence of a CRA and incidence of geo ... Full text Link to item Cite

Four-Dimensional Microscope-Integrated Optical Coherence Tomography Guidance in a Model Eye Subretinal Surgery.

Conference Retina · October 2019 PURPOSE:: Subretinal delivery of stem cells and gene therapy vectors hold great promise in clinical care. Delivery techniques are evolving. We investigate the utility of 4-dimensional (volumes over time) microscope-integrated optical coherence tomography ( ... Full text Link to item Cite

Neuroretinal Imaging Inflammatory Biomarkers Anticipating Radiation-Induced Macular Edema.

Journal Article Retina · October 2019 Full text Link to item Cite

Capturing Macular Vascular Development in an Infant With Retinopathy of Prematurity.

Journal Article JAMA Ophthalmol · September 1, 2019 Full text Link to item Cite

Longitudinal Study of Visual Function in Dry Age-Related Macular Degeneration at 12 Months.

Journal Article Ophthalmol Retina · August 2019 PURPOSE: To report the 1-year progression of visual impairment on psychophysical tests of visual function in patients with early and intermediate age-related macular degeneration (AMD). DESIGN: Prospective, observational study. PARTICIPANTS: Patients with ... Full text Link to item Cite

Blue Light Fundus Autofluorescence in Coats Disease.

Journal Article Retina · August 2019 Full text Link to item Cite

A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration.

Journal Article Nat Commun · July 26, 2019 Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly in the developed world. While treatment is effective for the neovascular or "wet" form of AMD, no therapy is successful for the non-neovascular or "dry" form. He ... Full text Link to item Cite

Demonstration of anatomical development of the human macula within the first 5 years of life using handheld OCT.

Journal Article Int Ophthalmol · July 2019 PURPOSE: To demonstrate the anatomical development of the human macula using handheld spectral domain optical coherence tomography (SD-OCT) during the first 5 years of life. METHODS: This study is a cross-sectional, observational case series. Thirty-five n ... Full text Link to item Cite

Retinal Degeneration After Accidental Intravitreal Injection of Ropivacaine During Strabismus Surgery.

Journal Article Retina · July 2019 Full text Link to item Cite

Monocyte-related biomarkers of intermediate age-related macular degeneration

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2019 Link to item Cite

Classification of Intermediate Age-Related Macular Degeneration by Short-Term Risk for Atrophy on Spectral Domain Optical Coherence Tomography

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2019 Link to item Cite

Choriovitreal Neovascularization After Resolution of Infectious Chorioretinitis.

Journal Article Retina · June 2019 This report describes the first documented case of choriovitreal neovascularization (CVNV) occurring after infectious chorioretinitis, with OCT-angiography (OCT-A) demonstrating flow through the vitreal portion of the lesion, and response to anti-VEGF ther ... Full text Link to item Cite

Five-Year Follow-up of Nonfibrotic Scars in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal Article Ophthalmology · May 2019 PURPOSE: To describe changes in visual acuity (VA) and macular morphologic features at 5 years in eyes with nonfibrotic scar (NFS) identified at 1 year in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). DESIGN: Prospective coho ... Full text Link to item Cite

Ergonomic handheld OCT angiography probe optimized for pediatric and supine imaging.

Journal Article Biomed Opt Express · May 1, 2019 OCT angiography is a functional extension of OCT that allows for non-invasive imaging of retinal microvasculature. However, most current OCT angiography systems are tabletop systems that are typically used for imaging compliant, seated subjects. These syst ... Full text Link to item Cite

Macular Microvascular Findings in Familial Exudative Vitreoretinopathy on Optical Coherence Tomography Angiography.

Journal Article Ophthalmic Surg Lasers Imaging Retina · May 1, 2019 BACKGROUND AND OBJECTIVE: To describe depth-resolved macular microvasculature abnormalities in patients with familial exudative vitreoretinopathy (FEVR) using optical coherence tomography angiography (OCTA). PATIENTS AND METHODS: Twenty-two eyes (11 eyes o ... Full text Link to item Cite

Best Clinical Practice for Age-Related Macular Degeneration Imaging

Journal Article Journal of VitreoRetinal Diseases · May 1, 2019 Purpose: To identify best clinical practices for macular degeneration imaging. Methods: We reviewed best clinical practices for imaging patients with age-related macular degeneration. These recommendations are based on different levels of evidence (I-III). ... Full text Cite

Three-dimensional pattern of extraretinal neovascular development in retinopathy of prematurity.

Journal Article Graefes Arch Clin Exp Ophthalmol · April 2019 BACKGROUND: The application of three-dimensional (3D) visualization techniques to evaluate the earliest visible onset of abnormal retinal vascular development in preterm infants with retinopathy of prematurity (ROP), using bedside non-contact optical coher ... Full text Link to item Cite

Distribution of OCT Features within Areas of Macular Atrophy or Scar after 2 Years of Anti-VEGF Treatment for Neovascular AMD in CATT.

Journal Article Ophthalmol Retina · April 2019 PURPOSE: Macular atrophy and scar increase in prevalence during treatment for neovascular age-related macular degeneration and are associated with poor visual acuity. We sought to identify the distribution of spectral-domain OCT (SD-OCT)-determined feature ... Full text Link to item Cite

Experimental Evidence Behind Clinical Trial Outcomes in Retinopathy of Prematurity.

Journal Article Ophthalmic Surg Lasers Imaging Retina · April 1, 2019 Treatment of severe retinopathy of prematurity (ROP) has evolved over the last decade. This article reviews recent clinical trials and experimental evidence that supports clinical outcomes and observations, including the efficacy of anti-vascular endotheli ... Full text Link to item Cite

Development of a Retinopathy of Prematurity Activity Scale and Clinical Outcome Measures for Use in Clinical Trials.

Journal Article JAMA Ophthalmol · March 1, 2019 IMPORTANCE: To facilitate drug and device development for neonates, the International Neonatal Consortium brings together key stakeholders, including pharmaceutical companies, practitioners, regulators, funding agencies, scientists, and families, to addres ... Full text Link to item Cite

Macular Morphology and Visual Acuity in Year Five of the Comparison of Age-related Macular Degeneration Treatments Trials.

Conference Ophthalmology · February 2019 PURPOSE: To evaluate associations of morphologic features with 5-year visual acuity (VA) in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). DESIGN: Cohort study within a randomized clinical trial. PARTICIPANTS: Participants in ... Full text Link to item Cite

Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report No. 17.

Journal Article Ophthalmology · February 2019 PURPOSE: To investigate the natural history and genetic associations of drusenoid pigment epithelial detachment (DPED) associated with age-related macular degeneration (AMD). DESIGN: Retrospective analysis of a prospective cohort study. PARTICIPANTS: Of th ... Full text Link to item Cite

Comparison of Optical Coherence Tomography With Fundus Photographs, Fluorescein Angiography, and Histopathologic Analysis in Assessing Coats Disease.

Journal Article JAMA Ophthalmol · February 1, 2019 IMPORTANCE: Coats disease is a rare pediatric vitreoretinopathy that can cause devastating visual and anatomic outcomes. OBJECTIVE: To compare optical coherence tomography (OCT) with fundus photographs, fluorescein angiography (FA), and histopathologic fin ... Full text Link to item Cite

Vascular Findings in a Small Retinoblastoma Tumor Using OCT Angiography.

Journal Article Ophthalmol Retina · February 2019 Full text Link to item Cite

LONGITUDINAL CHANGES IN THE OPTIC NERVE HEAD AND RETINA OVER TIME IN VERY YOUNG CHILDREN WITH FAMILIAL EXUDATIVE VITREORETINOPATHY.

Journal Article Retina · January 2019 PURPOSE: To explore vitreoretinal pathologies and their longitudinal changes visible on handheld optical coherence tomography (OCT) of young children with familial exudative vitreoretinopathy. METHODS: The authors retrospectively analyzed handheld OCT imag ... Full text Link to item Cite

Imaging Infant Retinal Vasculature with OCT Angiography.

Journal Article Ophthalmol Retina · January 2019 Full text Link to item Cite

Subfoveal Lucency after Treatment of Vitreomacular Traction without Macular Hole in the Phase 3 Trials of Ocriplasmin Vitreolysis.

Journal Article Ophthalmol Retina · January 2019 PURPOSE: To describe the clinical impact of subfoveal lucency (SFL) seen on OCT before and after treatment of vitreomacular traction (VMT) or symptomatic vitreomacular adhesion (VMA) without macular hole (MH) in the prospective phase 3 trials of ocriplasmi ... Full text Link to item Cite

Understanding the variability of handheld spectral-domain optical coherence tomography measurements in supine infants.

Journal Article PLoS One · 2019 PURPOSE: Central foveal thickness (CFT) measurements from optical coherence tomography (OCT) scans provide a precise measure of severity of pathologic changes in the fovea, progress of disease and response to treatment. Although these measures are addition ... Full text Link to item Cite

Handbook of pediatric retinal OCT and the eye-brain connection

Book · January 1, 2019 Optical Coherence Tomography (OCT) plays a vital role in pediatric retina diagnosis, often revealing unrecognized retinal disorders and connections to brain injury, disease, and delayed neurodevelopment. Handbook of Pediatric Retinal OCT and the Eye-Brain ... Full text Cite

OCT and OCTA image capture in the nursery, clinic, and operating room

Chapter · January 1, 2019 Different scan protocols are useful when performing optical coherence tomography (OCT) on a cooperative patient who is able to fixate versus on an infant or young child. Although there are overlaps in scan acquisition patterns across different commercial s ... Full text Cite

Introduction to age-dependent features in pediatric OCT imaging

Chapter · January 1, 2019 An overview of age-dependent features is presented. ... Full text Cite

Incontinentia pigmenti

Chapter · January 1, 2019 Incontinentia pigmenti (IKBKG/NEMO gene-related retinopathy, Bloch-Sulzberger syndrome) is an X-linked dominant disorder characterized by abnormalities of the skin, teeth, nails, hair, retina, and central nervous system (CNS) and usually lethal before birt ... Full text Cite

Coats disease and coats plus syndrome

Chapter · January 1, 2019 Coats disease, or Leber multiple miliary aneurysm disease, is characterized by idiopathic retinal vascular telangiectasias that can occur with retinal exudates and exudative retinal detachments. In this chapter, we discuss the clinical features, optical co ... Full text Cite

Inflammatory and idiopathic choroidal neovascularization

Chapter · January 1, 2019 This chapter reviews the imaging findings for diagnosis and monitoring treatment response of inflammatory pediatric choroidal neovascular membranes. ... Full text Cite

Introduction to OCT imaging in infants and children

Chapter · January 1, 2019 Full text Cite

Familial exudative vitreoretinopathy and norrie disease

Chapter · January 1, 2019 Familial exudative vitreoretinopathy (FEVR), Norrie disease, and other retinal diseases with a FEVR-like appearance are diseases of abnormal vascular development with peripheral retinal vascular nonperfusion as a predominant feature. Optical coherence tomo ... Full text Cite

Retinopathy of prematurity

Chapter · January 1, 2019 Retinopathy of prematurity (ROP) is identified clinically by a pattern of incomplete and abnormal retinal vessel development in preterm infants. Assessment is centered on determining whether retinal findings indicate a course of disease that requires treat ... Full text Cite

Understanding the variability of handheld spectral-domain optical coherence tomography measurements in supine infants

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2019 Cite

Progression of Geographic Atrophy in Age-related Macular Degeneration: AREDS2 Report Number 16.

Journal Article Ophthalmology · December 2018 PURPOSE: To analyze the prevalence, incidence, and clinical characteristics of eyes with geographic atrophy (GA) in age-related macular degeneration (AMD), including clinical and genetic factors affecting enlargement. DESIGN: Prospective cohort study withi ... Full text Link to item Cite

Visualizing Macular Microvasculature Anomalies in 2 Infants With Treated Retinopathy of Prematurity.

Journal Article JAMA Ophthalmol · December 1, 2018 Full text Link to item Cite

Deep learning for retinopathy of prematurity screening.

Journal Article Br J Ophthalmol · November 23, 2018 Full text Link to item Cite

Depth-Based, Motion-Stabilized Colorization of Microscope-Integrated Optical Coherence Tomography Volumes for Microscope-Independent Microsurgery.

Journal Article Transl Vis Sci Technol · November 2018 PURPOSE: We develop and assess the impact of depth-based, motion-stabilized colorization (color) of microscope-integrated optical coherence tomography (MIOCT) volumes on microsurgical performance and ability to interpret surgical volumes. METHODS: Color wa ... Full text Link to item Cite

Handheld Adaptive Optics Scanning Laser Ophthalmoscope.

Journal Article Optica · September 20, 2018 Adaptive optics scanning laser ophthalmoscopy (AOSLO) has enabled in vivo visualization and enhanced understanding of retinal structure and function. Current generation AOSLOs have a large footprint and are mainly limited to imaging cooperative adult subje ... Full text Link to item Cite

VISUALIZATION FROM INTRAOPERATIVE SWEPT-SOURCE MICROSCOPE-INTEGRATED OPTICAL COHERENCE TOMOGRAPHY IN VITRECTOMY FOR COMPLICATIONS OF PROLIFERATIVE DIABETIC RETINOPATHY.

Journal Article Retina · September 2018 PURPOSE: To evaluate the use of live volumetric (4D) intraoperative swept-source microscope-integrated optical coherence tomography in vitrectomy for proliferative diabetic retinopathy complications. METHODS: In this prospective study, we analyzed a subgro ... Full text Link to item Cite

Spectral-Domain OCT Findings of Retinal Vascular-Avascular Junction in Infants with Retinopathy of Prematurity.

Journal Article Ophthalmol Retina · September 2018 PURPOSE: Bedside examination of premature infants at risk for retinopathy of prematurity (ROP) is predominantly performed with ophthalmoscopic en face viewing of the retina. While postmortem retinal microstructures have been studied at the vascular-avascul ... Full text Link to item Cite

HANDHELD SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY IMAGING THROUGH THE UNDILATED PUPIL IN INFANTS BORN PRETERM OR WITH HYPOXIC INJURY OR HYDROCEPHALUS.

Journal Article Retina · August 2018 PURPOSE: The authors investigated feasibility of undilated handheld spectral domain optical coherence tomography (SDOCT) retinal imaging in preterm infants and children with neurologic abnormalities. METHODS: Under an institutional review board-approved pr ... Full text Link to item Cite

Development and Course of Scars in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal Article Ophthalmology · July 2018 PURPOSE: To describe risk factors for scar formation and changes to fibrotic scar through 5 years in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). DESIGN: Multicenter, prospective cohort study. PARTICIPANTS: A total of 1061 s ... Full text Link to item Cite

Handheld Adaptive Optics Scanning Laser Ophthalmoscope for in vivo Photoreceptor Imaging of Supine Adults and Neonates

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Foveal vascular development in pediatric eyes assessed using optical coherence tomography angiography

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Long term Follow up of non-fibrotic scars in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT)

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Use of 3D printing technology in fabricating intraoperative OCT compatible ophthalmic tools

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Development of microscope-integrated optical coherence tomography (MIOCT) generated topography maps for corneal astigmatic axis detection

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Longitudinal progression of visual function metrics in early and intermediate age-related macular degeneration

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Use of mobile MyVisionTrack (mVT) technology as a remote visual function metric in Early and Intermediate Age-Related Macular Degeneration

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Hand held OCT probe optimized for supine optical coherence tomography angiography

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Axial Position-Based Colorization Improves Intraoperative Visualization of Live Volumetric (4D) Microscope-Integrated Optical Coherence Tomography (MIOCT)

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Effects of multifocal and monofocal intraocular lenses on swept-source microscope-integrated optical coherence tomography (SS-MIOCT) image quality in a model eye.

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Spectral-domain optical coherence tomography findings in Coats' disease

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Baseline Predictors for Five-Year Visual Acuity Outcomes in the Comparison of AMD Treatment Trials.

Journal Article Ophthalmol Retina · June 2018 PURPOSE: To determine baseline predictors of visual acuity (VA) outcomes at 5 years after initiating treatment with ranibizumab or bevacizumab for neovascular age-related macular degeneration (AMD). DESIGN: Secondary analysis of data from a cohort study. P ... Full text Link to item Cite

Macular Features on Spectral-Domain Optical Coherence Tomography Imaging Associated With Visual Acuity in Coats' Disease.

Journal Article Invest Ophthalmol Vis Sci · June 1, 2018 PURPOSE: To investigate the association between macular features on spectral-domain optical coherence tomography (SD-OCT) and visual acuity (VA) in Coats' disease. METHODS: Thirty-nine eyes (39 patients) with SD-OCT from January 1, 2008 to December 31, 201 ... Full text Link to item Cite

Visual Function Metrics in Early and Intermediate Dry Age-related Macular Degeneration for Use as Clinical Trial Endpoints.

Journal Article Am J Ophthalmol · May 2018 PURPOSE: To evaluate and quantify visual function metrics to be used as endpoints of age-related macular degeneration (AMD) stages and visual acuity (VA) loss in patients with early and intermediate AMD. DESIGN: Cross-sectional analysis of baseline data fr ... Full text Link to item Cite

Fluorescein Angiographic Characteristics of Macular Edema During Infancy.

Journal Article JAMA Ophthalmol · May 1, 2018 IMPORTANCE: Macular edema during infancy, a subclinical feature identified in premature infants by handheld spectral-domain optical coherence tomography (SD-OCT), has been associated with poorer visual acuity and neurodevelopmental outcomes. Features of ma ... Full text Link to item Cite

Real-Time Volumetric Imaging of Vitreoretinal Surgery with a Prototype Microscope-Integrated Swept-Source OCT Device.

Journal Article Ophthalmol Retina · May 2018 PURPOSE: To evaluate the images produced in an initial surgical series of intraoperative near-real-time volumetric swept-source (SS) OCT imaging. DESIGN: Prospective translational study. PARTICIPANTS: Forty-one consecutive adult patients undergoing vitreor ... Full text Link to item Cite

Four-Dimensional Microscope-Integrated OCT Use in Argus II Placement.

Journal Article Ophthalmol Retina · May 2018 Full text Link to item Cite

Linking OCT, Angiographic, and Photographic Lesion Components in Neovascular Age-Related Macular Degeneration.

Journal Article Ophthalmol Retina · May 2018 PURPOSE: To develop methods to make precise comparisons of specific retinal features between and within spectral-domain (SD) OCT images, color fundus photography (CFP) images, and fluorescein angiography (FA) images in eyes treated with anti-vascular endot ... Full text Link to item Cite

Volumetric Measurement of Subretinal Blebs Using Microscope-Integrated Optical Coherence Tomography.

Journal Article Transl Vis Sci Technol · April 2018 PURPOSE: We advance studies of subretinal treatments by developing a microscope-integrated optical coherence tomography (MIOCT) image-based method for measuring the volume of therapeutics delivered into the subretinal space. METHODS: A MIOCT image-based vo ... Full text Link to item Cite

Association of Low Luminance Questionnaire With Objective Functional Measures in Early and Intermediate Age-Related Macular Degeneration.

Journal Article Invest Ophthalmol Vis Sci · January 1, 2018 PURPOSE: To determine whether Low Luminance Questionnaire (LLQ) scores are associated with objective measures of visual function in early and intermediate age-related macular degeneration (AMD). METHODS: Cross-sectional study of subjects with early AMD Age ... Full text Link to item Cite

Integrating optical imaging of mummy mask cartonnage

Conference IS and T Archiving Conference, ARCHIVING 2018 · January 1, 2018 This rapid development and testing project captured data from multiple digital imaging techniques to try to see texts in papyrus mâché mummy mask cartonnage layers. Prior studies by other scholars destroyed the masks to access the papyri, denying future re ... Cite

Teleoperating robots from arbitrary viewpoints in surgical contexts

Conference IEEE International Conference on Intelligent Robots and Systems · December 13, 2017 Intraoperative 3D imaging has great potential for enhancing surgical visualization. This is especially so in ophthalmic surgery where live volumetric imaging from optical coherence tomography systems recently incorporated into surgical microscopes has free ... Full text Cite

Optical Coherence Tomography Predictors of Risk for Progression to Non-Neovascular Atrophic Age-Related Macular Degeneration.

Conference Ophthalmology · December 2017 PURPOSE: Appearance of geographic atrophy (GA) on color photography (CP) is preceded by specific features on spectral-domain optical coherence tomography (SD OCT). We aimed to build SD OCT-based risk assessment models for 5-year new onset of GA and central ... Full text Link to item Cite

Characterization of Long Working Distance Optical Coherence Tomography for Imaging of Pediatric Retinal Pathology.

Journal Article Transl Vis Sci Technol · October 2017 PURPOSE: We determined the feasibility of fovea and optic nerve head imaging with a long working distance (LWD) swept source optical coherence tomography (OCT) prototype in adults, teenagers, and young children. METHODS: A prototype swept source OCT system ... Full text Link to item Cite

Comparison of Visual Outcomes in Coats' Disease: A 20-Year Experience.

Journal Article Ophthalmology · September 2017 PURPOSE: To report differences in visual acuities among patients with Coats' disease who sought treatment at a tertiary care university-based practice. DESIGN: Single-center retrospective cohort study. PARTICIPANTS: Patients with Coats' disease diagnosed c ... Full text Link to item Cite

Intra-operative microscope-integrated swept-source optical coherence tomography guided placement of Argus II retinal prosthesis.

Journal Article Acta Ophthalmol · August 2017 Full text Link to item Cite

ASSESSMENT OF THE RETINAL STRUCTURE IN CHILDREN WITH INCONTINENTIA PIGMENTI.

Journal Article Retina · August 2017 PURPOSE: This report aims at expanding the current knowledge of retinal microanatomy in children with incontinentia pigmenti using hand-held spectral domain optical coherence tomography (SDOCT). METHODS: We reviewed OCT scans from 7 children (4 weeks-13 ye ... Full text Link to item Cite