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Mustafa Shadi Rifaat Bashir

Professor of Radiology
Radiology, Abdominal Imaging
Dept of Radiology, Box 3808, Durham, NC 27710

Selected Publications


Deep learning-based compressed SENSE improved diffusion-weighted image quality and liver cancer detection: A prospective study.

Journal Article Magn Reson Imaging · September 2024 PURPOSE: To assess whether diffusion-weighted imaging (DWI) with Compressed SENSE (CS) and deep learning (DL-CS-DWI) can improve image quality and lesion detection in patients at risk for hepatocellular carcinoma (HCC). METHODS: This single-center prospect ... Full text Link to item Cite

Best Practice for MRI Diagnostic Accuracy Research With Lessons and Examples from the LI-RADS Individual Participant Data Group.

Journal Article J Magn Reson Imaging · July 2024 Medical imaging diagnostic test accuracy research is strengthened by adhering to best practices for study design, data collection, data documentation, and study reporting. In this review, key elements of such research are discussed, and specific recommenda ... Full text Link to item Cite

Automated selection of abdominal MRI series using a DICOM metadata classifier and selective use of a pixel-based classifier.

Journal Article Abdom Radiol (NY) · June 11, 2024 Accurate, automated MRI series identification is important for many applications, including display ("hanging") protocols, machine learning, and radiomics. The use of the series description or a pixel-based classifier each has limitations. We demonstrate a ... Full text Link to item Cite

Prognostic MRI features to predict postresection survivals for very early to intermediate stage hepatocellular carcinoma.

Journal Article Eur Radiol · May 2024 OBJECTIVES: Contrast-enhanced MRI can provide individualized prognostic information for hepatocellular carcinoma (HCC). We aimed to investigate the value of MRI features to predict early (≤ 2 years)/late (> 2 years) recurrence-free survival (E-RFS and L-RF ... Full text Link to item Cite

A Method for Efficient De-identification of DICOM Metadata and Burned-in Pixel Text.

Journal Article J Imaging Inform Med · April 8, 2024 De-identification of DICOM images is an essential component of medical image research. While many established methods exist for the safe removal of protected health information (PHI) in DICOM metadata, approaches for the removal of PHI "burned-in" to image ... Full text Link to item Cite

Identifying a stable and generalizable factor structure of major depressive disorder across three large longitudinal cohorts.

Journal Article Psychiatry Res · March 2024 The Patient Health Questionnaire 9 (PHQ-9) is the current standard outpatient screening tool for measuring and tracking the nine symptoms of major depressive disorder (MDD). While the PHQ-9 was originally conceptualized as a unidimensional measure, it has ... Full text Link to item Cite

LI-RADS CT and MRI Ancillary Feature Association with Hepatocellular Carcinoma and Malignancy: An Individual Participant Data Meta-Analysis.

Journal Article Radiology · February 2024 Background The independent contribution of each Liver Imaging Reporting and Data System (LI-RADS) CT or MRI ancillary feature (AF) has not been established. Purpose To evaluate the association of LI-RADS AFs with hepatocellular carcinoma (HCC) and malignan ... Full text Link to item Cite

Are dilution, slow injection and care bolus technique the causal solution to mitigating arterial-phase artifacts on gadoxetic acid-enhanced MRI? A large-cohort study.

Journal Article Eur Radiol · January 20, 2024 OBJECTIVE: Arterial-phase artifacts are gadoxetic acid (GA)-enhanced MRI's major drawback, ranging from 5 to 39%. We evaluate the effect of dilution and slow injection of GA using automated fluoroscopic triggering on liver MRI arterial-phase (AP) acquisiti ... Full text Link to item Cite

Abbreviated MRI Protocols in the Abdomen and Pelvis.

Journal Article J Magn Reson Imaging · January 2024 Abbreviated MRI (AMRI) protocols rely on the acquisition of a limited number of sequences tailored to a specific question. The main objective of AMRI protocols is to reduce exam duration and costs, while maintaining an acceptable diagnostic performance. AM ... Full text Link to item Cite

Design of the phase 3 MAESTRO clinical program to evaluate resmetirom for the treatment of nonalcoholic steatohepatitis.

Journal Article Aliment Pharmacol Ther · January 2024 BACKGROUND: Non-alcoholic steatohepatitis (NASH) is a progressive form of non-alcoholic fatty liver disease (NAFLD) associated with steatosis, hepatocellular injury, inflammation and fibrosis. In a Phase 2 trial in adults with NASH (NCT02912260), resmetiro ... Full text Link to item Cite

Diagnosis and Monitoring of Nonalcoholic Steatohepatitis: Current State and Future Directions.

Journal Article Radiology · January 2024 Nonalcoholic fatty liver disease (NAFLD) is a common liver disease, with a worldwide prevalence of 25%. NAFLD is a spectrum that includes nonalcoholic fatty liver defined histologically by isolated hepatocytes steatosis without inflammation and nonalcoholi ... Full text Link to item Cite

Comparative Performance of 2018 LI-RADS versus Modified LIRADS (mLI-RADS): An Individual Participant Data Meta-Analysis.

Journal Article J Magn Reson Imaging · December 1, 2023 BACKGROUND: LI-RADS version 2018 (v2018) is used for non-invasive diagnosis of hepatocellular carcinoma (HCC). A recently proposed modification (known as mLI-RADS) demonstrated improved sensitivity while maintaining specificity and positive predictive valu ... Full text Link to item Cite

Individual Participant Data Meta-Analysis of LR-5 in LI-RADS Version 2018 versus Revised LI-RADS for Hepatocellular Carcinoma Diagnosis.

Journal Article Radiology · December 2023 Background A simplification of the Liver Imaging Reporting and Data System (LI-RADS) version 2018 (v2018), revised LI-RADS (rLI-RADS), has been proposed for imaging-based diagnosis of hepatocellular carcinoma (HCC). Single-site data suggest that rLI-RADS c ... Full text Link to item Cite

Nutrition assessment and MASH severity in children using the Healthy Eating Index.

Journal Article Hepatol Commun · December 1, 2023 BACKGROUND: Pediatric metabolic-associated fatty liver disease (MAFLD) is a global health problem, with lifestyle modification as its major therapeutic strategy. Rigorous characterization of dietary content on MAFLD in children is lacking. We hypothesized ... Full text Link to item Cite

Resmetirom for nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled phase 3 trial.

Journal Article Nat Med · November 2023 Nonalcoholic steatohepatitis (NASH) is a progressive liver disease with no approved treatment. MAESTRO-NAFLD-1 was a 52-week randomized, double-blind, placebo-controlled phase 3 trial evaluating the safety of resmetirom in adults with nonalcoholic fatty li ... Full text Link to item Cite

Development of a Model including MRI Features for Predicting Advanced-stage Recurrence of Hepatocellular Carcinoma after Liver Resection.

Journal Article Radiology · November 2023 Background Identifying patients at high risk for advanced-stage hepatocellular carcinoma (HCC) recurrence after liver resection may improve patient survival. Purpose To develop a model including MRI features for predicting postoperative advanced-stage HCC ... Full text Link to item Cite

ACR Appropriateness Criteria® Abnormal Liver Function Tests.

Journal Article J Am Coll Radiol · November 2023 Liver function tests are commonly obtained in symptomatic and asymptomatic patients. Various overlapping lab patterns can be seen due to derangement of hepatocytes and bile ducts function. Imaging tests are pursued to identify underlying etiology and guide ... Full text Link to item Cite

The current status of imaging in liver fibrosis.

Journal Article Nat Rev Gastroenterol Hepatol · October 2023 Full text Link to item Cite

AHRR Hypomethylation mediates the association between maternal smoking and metabolic profiles in children.

Journal Article Hepatol Commun · October 1, 2023 BACKGROUND: Tobacco smoking during pregnancy is associated with metabolic dysfunction in children, but mechanistic insights remain limited. Hypomethylation of cg05575921 in the aryl hydrocarbon receptor repressor (AHRR) gene is associated with in utero tob ... Full text Open Access Link to item Cite

Deep learning-based compressed SENSE improved diffusion-weighted image quality and liver cancer detection: A prospective study.

Journal Article Magn Reson Imaging · September 2024 PURPOSE: To assess whether diffusion-weighted imaging (DWI) with Compressed SENSE (CS) and deep learning (DL-CS-DWI) can improve image quality and lesion detection in patients at risk for hepatocellular carcinoma (HCC). METHODS: This single-center prospect ... Full text Link to item Cite

Best Practice for MRI Diagnostic Accuracy Research With Lessons and Examples from the LI-RADS Individual Participant Data Group.

Journal Article J Magn Reson Imaging · July 2024 Medical imaging diagnostic test accuracy research is strengthened by adhering to best practices for study design, data collection, data documentation, and study reporting. In this review, key elements of such research are discussed, and specific recommenda ... Full text Link to item Cite

Automated selection of abdominal MRI series using a DICOM metadata classifier and selective use of a pixel-based classifier.

Journal Article Abdom Radiol (NY) · June 11, 2024 Accurate, automated MRI series identification is important for many applications, including display ("hanging") protocols, machine learning, and radiomics. The use of the series description or a pixel-based classifier each has limitations. We demonstrate a ... Full text Link to item Cite

Prognostic MRI features to predict postresection survivals for very early to intermediate stage hepatocellular carcinoma.

Journal Article Eur Radiol · May 2024 OBJECTIVES: Contrast-enhanced MRI can provide individualized prognostic information for hepatocellular carcinoma (HCC). We aimed to investigate the value of MRI features to predict early (≤ 2 years)/late (> 2 years) recurrence-free survival (E-RFS and L-RF ... Full text Link to item Cite

A Method for Efficient De-identification of DICOM Metadata and Burned-in Pixel Text.

Journal Article J Imaging Inform Med · April 8, 2024 De-identification of DICOM images is an essential component of medical image research. While many established methods exist for the safe removal of protected health information (PHI) in DICOM metadata, approaches for the removal of PHI "burned-in" to image ... Full text Link to item Cite

Identifying a stable and generalizable factor structure of major depressive disorder across three large longitudinal cohorts.

Journal Article Psychiatry Res · March 2024 The Patient Health Questionnaire 9 (PHQ-9) is the current standard outpatient screening tool for measuring and tracking the nine symptoms of major depressive disorder (MDD). While the PHQ-9 was originally conceptualized as a unidimensional measure, it has ... Full text Link to item Cite

LI-RADS CT and MRI Ancillary Feature Association with Hepatocellular Carcinoma and Malignancy: An Individual Participant Data Meta-Analysis.

Journal Article Radiology · February 2024 Background The independent contribution of each Liver Imaging Reporting and Data System (LI-RADS) CT or MRI ancillary feature (AF) has not been established. Purpose To evaluate the association of LI-RADS AFs with hepatocellular carcinoma (HCC) and malignan ... Full text Link to item Cite

Are dilution, slow injection and care bolus technique the causal solution to mitigating arterial-phase artifacts on gadoxetic acid-enhanced MRI? A large-cohort study.

Journal Article Eur Radiol · January 20, 2024 OBJECTIVE: Arterial-phase artifacts are gadoxetic acid (GA)-enhanced MRI's major drawback, ranging from 5 to 39%. We evaluate the effect of dilution and slow injection of GA using automated fluoroscopic triggering on liver MRI arterial-phase (AP) acquisiti ... Full text Link to item Cite

Abbreviated MRI Protocols in the Abdomen and Pelvis.

Journal Article J Magn Reson Imaging · January 2024 Abbreviated MRI (AMRI) protocols rely on the acquisition of a limited number of sequences tailored to a specific question. The main objective of AMRI protocols is to reduce exam duration and costs, while maintaining an acceptable diagnostic performance. AM ... Full text Link to item Cite

Design of the phase 3 MAESTRO clinical program to evaluate resmetirom for the treatment of nonalcoholic steatohepatitis.

Journal Article Aliment Pharmacol Ther · January 2024 BACKGROUND: Non-alcoholic steatohepatitis (NASH) is a progressive form of non-alcoholic fatty liver disease (NAFLD) associated with steatosis, hepatocellular injury, inflammation and fibrosis. In a Phase 2 trial in adults with NASH (NCT02912260), resmetiro ... Full text Link to item Cite

Diagnosis and Monitoring of Nonalcoholic Steatohepatitis: Current State and Future Directions.

Journal Article Radiology · January 2024 Nonalcoholic fatty liver disease (NAFLD) is a common liver disease, with a worldwide prevalence of 25%. NAFLD is a spectrum that includes nonalcoholic fatty liver defined histologically by isolated hepatocytes steatosis without inflammation and nonalcoholi ... Full text Link to item Cite

Comparative Performance of 2018 LI-RADS versus Modified LIRADS (mLI-RADS): An Individual Participant Data Meta-Analysis.

Journal Article J Magn Reson Imaging · December 1, 2023 BACKGROUND: LI-RADS version 2018 (v2018) is used for non-invasive diagnosis of hepatocellular carcinoma (HCC). A recently proposed modification (known as mLI-RADS) demonstrated improved sensitivity while maintaining specificity and positive predictive valu ... Full text Link to item Cite

Individual Participant Data Meta-Analysis of LR-5 in LI-RADS Version 2018 versus Revised LI-RADS for Hepatocellular Carcinoma Diagnosis.

Journal Article Radiology · December 2023 Background A simplification of the Liver Imaging Reporting and Data System (LI-RADS) version 2018 (v2018), revised LI-RADS (rLI-RADS), has been proposed for imaging-based diagnosis of hepatocellular carcinoma (HCC). Single-site data suggest that rLI-RADS c ... Full text Link to item Cite

Nutrition assessment and MASH severity in children using the Healthy Eating Index.

Journal Article Hepatol Commun · December 1, 2023 BACKGROUND: Pediatric metabolic-associated fatty liver disease (MAFLD) is a global health problem, with lifestyle modification as its major therapeutic strategy. Rigorous characterization of dietary content on MAFLD in children is lacking. We hypothesized ... Full text Link to item Cite

Resmetirom for nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled phase 3 trial.

Journal Article Nat Med · November 2023 Nonalcoholic steatohepatitis (NASH) is a progressive liver disease with no approved treatment. MAESTRO-NAFLD-1 was a 52-week randomized, double-blind, placebo-controlled phase 3 trial evaluating the safety of resmetirom in adults with nonalcoholic fatty li ... Full text Link to item Cite

Development of a Model including MRI Features for Predicting Advanced-stage Recurrence of Hepatocellular Carcinoma after Liver Resection.

Journal Article Radiology · November 2023 Background Identifying patients at high risk for advanced-stage hepatocellular carcinoma (HCC) recurrence after liver resection may improve patient survival. Purpose To develop a model including MRI features for predicting postoperative advanced-stage HCC ... Full text Link to item Cite

ACR Appropriateness Criteria® Abnormal Liver Function Tests.

Journal Article J Am Coll Radiol · November 2023 Liver function tests are commonly obtained in symptomatic and asymptomatic patients. Various overlapping lab patterns can be seen due to derangement of hepatocytes and bile ducts function. Imaging tests are pursued to identify underlying etiology and guide ... Full text Link to item Cite

The current status of imaging in liver fibrosis.

Journal Article Nat Rev Gastroenterol Hepatol · October 2023 Full text Link to item Cite

AHRR Hypomethylation mediates the association between maternal smoking and metabolic profiles in children.

Journal Article Hepatol Commun · October 1, 2023 BACKGROUND: Tobacco smoking during pregnancy is associated with metabolic dysfunction in children, but mechanistic insights remain limited. Hypomethylation of cg05575921 in the aryl hydrocarbon receptor repressor (AHRR) gene is associated with in utero tob ... Full text Open Access Link to item Cite

Duke Liver Dataset: A Publicly Available Liver MRI Dataset with Liver Segmentation Masks and Series Labels.

Journal Article Radiol Artif Intell · September 2023 The Duke Liver Dataset contains 2146 abdominal MRI series from 105 patients, including a majority with cirrhotic features, and 310 image series with corresponding manually segmented liver masks. ... Full text Link to item Cite

Imaging prognostication and tumor biology in hepatocellular carcinoma.

Journal Article J Liver Cancer · September 2023 Hepatocellular carcinoma (HCC) is the most common primary liver malignancy, and represents a significant global health burden with rising incidence rates, despite a more thorough understanding of the etiology and biology of HCC, as well as advancements in ... Full text Link to item Cite

A Faster Prostate MRI: Comparing a Novel Denoised, Single-Average T2 Sequence to the Conventional Multiaverage T2 Sequence Regarding Lesion Detection and PI-RADS Score Assessment.

Journal Article J Magn Reson Imaging · August 2023 BACKGROUND: The T2 w sequence is a standard component of a prostate MRI examination; however, it is time-consuming, requiring multiple signal averages to achieve acceptable image quality. PURPOSE/HYPOTHESIS: To determine whether a denoised, single-average ... Full text Link to item Cite

Fibrosis Progression Rate in Biopsy-Proven Nonalcoholic Fatty Liver Disease Among People With Diabetes Versus People Without Diabetes: A Multicenter Study.

Journal Article Gastroenterology · August 2023 BACKGROUND & AIMS: There are limited data regarding fibrosis progression in biopsy-proven nonalcoholic fatty liver disease (NAFLD) in people with type 2 diabetes mellitus (T2DM) compared with people without T2DM. We assessed the time to fibrosis progressio ... Full text Link to item Cite

Evaluation of Frailty Measures and Short-term Outcomes After Lung Transplantation.

Journal Article Chest · July 2023 BACKGROUND: Frailty, measured as a single construct, is associated variably with poor outcomes before and after lung transplantation. The usefulness of a comprehensive frailty assessment before transplantation is unknown. RESEARCH QUESTION: How are multipl ... Full text Link to item Cite

Towards optimal deep fusion of imaging and clinical data via a model-based description of fusion quality.

Journal Article Med Phys · June 2023 BACKGROUND: Due to intrinsic differences in data formatting, data structure, and underlying semantic information, the integration of imaging data with clinical data can be non-trivial. Optimal integration requires robust data fusion, that is, the process o ... Full text Link to item Cite

Updates on LI-RADS Treatment Response Criteria for Hepatocellular Carcinoma: Focusing on MRI.

Journal Article J Magn Reson Imaging · June 2023 As the incidence of hepatocellular carcinoma (HCC) and subsequent treatments with liver-directed therapies rise, the complexity of assessing lesion response has also increased. The Liver Imaging Reporting and Data Systems (LI-RADS) treatment response algor ... Full text Link to item Cite

A Multicenter Assessment of Interreader Reliability of LI-RADS Version 2018 for MRI and CT.

Journal Article Radiology · June 2023 Background Various limitations have impacted research evaluating reader agreement for Liver Imaging Reporting and Data System (LI-RADS). Purpose To assess reader agreement of LI-RADS in an international multicenter multireader setting using scrollable imag ... Full text Link to item Cite

Systematic Analysis of Common Factors Impacting Deep Learning Model Generalizability in Liver Segmentation.

Journal Article Radiol Artif Intell · May 2023 PURPOSE: To investigate the effect of training data type on generalizability of deep learning liver segmentation models. MATERIALS AND METHODS: This Health Insurance Portability and Accountability Act-compliant retrospective study included 860 MRI and CT a ... Full text Link to item Cite

Imaging to Predict Prognosis in Hepatocellular Carcinoma: Current and Future Perspectives.

Journal Article Radiology · May 2023 The focus of hepatocellular carcinoma (HCC) research for many years has been on noninvasive diagnosis. Standardized systematic algorithms composed of combinations of precise features now serve as diagnostic imaging markers of HCC and constitute a major inn ... Full text Cite

ACR Appropriateness Criteria® Right Upper Quadrant Pain: 2022 Update.

Journal Article J Am Coll Radiol · May 2023 Acute right upper quadrant pain is one of the most common presenting symptoms in hospital emergency departments, as well as outpatient settings. Although gallstone-related acute cholecystitis is a leading consideration in diagnosis, a myriad of extrabiliar ... Full text Link to item Cite

VICT2 Trait: Prognostic Alternative to Peritumoral Hepatobiliary Phase Hypointensity in HCC.

Journal Article Radiology · April 2023 Background Peritumoral hepatobiliary phase (HBP) hypointensity is an established prognostic imaging feature in hepatocellular carcinoma (HCC), often associated with microvascular invasion (MVI). Similar prognostic features are needed for non-HBP MRI. Purpo ... Full text Link to item Cite

Liver fat quantification in photon counting CT in head to head comparison with clinical MRI - First experience.

Journal Article Eur J Radiol · April 2023 PURPOSE: To compare liver fat quantification between MRI and photon-counting CT (PCCT). METHOD: A cylindrical phantom with inserts containing six concentrations of oil (0, 10, 20, 30, 50 and 100%) and oil-iodine mixtures (0, 10, 20, 30 and 50% fat +3 mg/mL ... Full text Link to item Cite

MRI Quantification of Placebo Effect in Nonalcoholic Steatohepatitis Clinical Trials.

Journal Article Radiology · March 2023 Background Several early-phase clinical trials for the treatment of nonalcoholic steatohepatitis (NASH) use liver fat content as measured with the MRI-derived proton density fat fraction (PDFF) for a primary outcome. These trials have shown relative reduct ... Full text Open Access Link to item Cite

Changes in abdominal adipose tissue depots assessed by MRI correlate with hepatic histologic improvement in non-alcoholic steatohepatitis.

Journal Article J Hepatol · February 2023 BACKGROUND & AIMS: Non-alcoholic steatohepatitis (NASH) is prevalent in adults with obesity and can progress to cirrhosis. In a secondary analysis of prospectively acquired data from the multicenter, randomized, placebo-controlled FLINT trial, we investiga ... Full text Link to item Cite

Comparing Survival Outcomes of Patients With LI-RADS-M Hepatocellular Carcinomas and Intrahepatic Cholangiocarcinomas.

Journal Article J Magn Reson Imaging · January 2023 BACKGROUND: There is a sparsity of data evaluating outcomes of patients with Liver Imaging Reporting and Data System (LI-RADS) (LR)-M lesions. PURPOSE: To compare overall survival (OS) and progression free survival (PFS) between hepatocellular carcinoma (H ... Full text Link to item Cite

CT-derived body composition measurements as predictors for neoadjuvant treatment tolerance and survival in gastroesophageal adenocarcinoma.

Journal Article Abdom Radiol (NY) · January 2023 PURPOSE: Treatment for gastroesophageal adenocarcinomas can result in significant morbidity and mortality. The purpose of this study is to supplement methods for choosing treatment strategy by assessing the relationship between CT-derived body composition, ... Full text Link to item Cite

Universal Liver Imaging Lexicon: Imaging Atlas for Research and Clinical Practice.

Journal Article Radiographics · January 2023 The use of standardized terms in assessing and reporting disease processes has well-established benefits, such as clear communication between radiologists and other health care providers, improved diagnostic accuracy and reproducibility, and the enhancemen ... Full text Link to item Cite

LR-3 and LR-4 Lesions Are More Likely to Be Hepatocellular Carcinoma in Transplant Patients with LR-5 or LR-TR Lesions.

Conference Dig Dis Sci · November 2022 BACKGROUND: Liver Imaging Reporting and Data System (LI-RADS) classifies liver nodules from LR-1 to LR-5 based on risk for hepatocellular carcinoma (HCC). It is challenging to know the nature of the LR-3 and LR-4 lesions. AIMS: To test our hypothesis that ... Full text Link to item Cite

Alterations in DNA methylation associate with fatty liver and metabolic abnormalities in a multi-ethnic cohort of pre-teenage children.

Journal Article Epigenetics · November 2022 Non-Alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in children. Epigenetic alterations, such as through DNA methylation (DNAm), may link adverse childhood exposures and fatty liver and provide non-invasive methods for i ... Full text Link to item Cite

Clinical and imaging predictors of the natural course of bland portal vein thrombus in cirrhotic patients.

Journal Article Abdom Radiol (NY) · November 2022 BACKGROUND: Portal vein thrombus (PVT) in cirrhotic patients is associated with worsening portal hypertension, leads to increased complexity of necessary interventions such as transjugular liver portosystemic shunt or liver transplantation, and is associat ... Full text Link to item Cite

Leveraging Artificial Intelligence to Enhance Peer Review: Missed Liver Lesions on Computed Tomographic Pulmonary Angiography.

Journal Article J Am Coll Radiol · November 2022 PURPOSE: The aim of this study was to use artificial intelligence (AI) to facilitate peer review for detection of missed suspicious liver lesions (SLLs) on CT pulmonary angiographic (CTPA) examinations. METHODS: This retrospective study included 1 month of ... Full text Link to item Cite

Transfusion Requirements with Hybrid Management of Placenta Accreta Spectrum Incorporating Targeted Embolization and a Selective Use of Delayed Hysterectomy.

Journal Article Am J Perinatol · October 2022 OBJECTIVE: This study compares the number of units of red blood cells (RBCs) transfused in patients with placenta accreta spectrum (PAS) treated with or without a multidisciplinary algorithm that includes placental uterine arterial embolization (P-UAE) and ... Full text Link to item Cite

Radiomics: a primer on high-throughput image phenotyping.

Journal Article Abdom Radiol (NY) · September 2022 Radiomics is a high-throughput approach to image phenotyping. It uses computer algorithms to extract and analyze a large number of quantitative features from radiological images. These radiomic features collectively describe unique patterns that can serve ... Full text Link to item Cite

Liver imaging: it is time to adopt standardized terminology.

Journal Article Eur Radiol · September 2022 Liver imaging plays a vital role in the management of patients at risk for hepatocellular carcinoma (HCC); however, progress in the field is challenged by nonuniform and inconsistent terminology in the published literature. The Steering Committee of the Am ... Full text Link to item Cite

Profiling hepatocellular carcinoma aggressiveness with contrast-enhanced ultrasound and gadoxetate disodium-enhanced MRI: An intra-individual comparative study based on the Liver Imaging Reporting and Data System.

Journal Article Eur J Radiol · September 2022 PURPOSE: Contrast-enhanced ultrasound (CEUS) and gadoxetate disodium-enhanced MRI (EOB-MRI) may synergize in profiling hepatocellular carcinoma (HCC) aggressiveness considering distinct imaging traits. This study aimed to intra-individually compare CEUS an ... Full text Link to item Cite

Modifying LI-RADS on Gadoxetate Disodium-Enhanced MRI: A Secondary Analysis of a Prospective Observational Study.

Journal Article J Magn Reson Imaging · August 2022 BACKGROUND: The Liver Imaging Reporting and Data System (LI-RADS) is widely used for diagnosing hepatocellular carcinoma (HCC), however, with unsatisfactory sensitivity, complex ancillary features, and inadequate integration with gadoxetate disodium (EOB)- ... Full text Link to item Cite

Aldafermin in patients with non-alcoholic steatohepatitis (ALPINE 2/3): a randomised, double-blind, placebo-controlled, phase 2b trial.

Journal Article Lancet Gastroenterol Hepatol · July 2022 BACKGROUND: Non-alcoholic steatohepatitis (NASH) is characterised by hepatic steatosis, inflammation, and injury, and is associated with an increased risk of liver transplantation and death. NASH affects more than 16 million people in the USA, and there is ... Full text Link to item Cite

Impact of Reference Standard on CT, MRI, and Contrast-enhanced US LI-RADS Diagnosis of Hepatocellular Carcinoma: A Meta-Analysis.

Journal Article Radiology · June 2022 See also the editorial by Ronot in this issue. Online supplemental material is available for this article. ... Full text Link to item Cite

Predicting microvascular invasion in hepatocellular carcinoma: A dual-institution study on gadoxetate disodium-enhanced MRI.

Journal Article Liver Int · May 2022 BACKGROUND & AIMS: Microvascular invasion (MVI) is an important risk factor in hepatocellular carcinoma (HCC), but its diagnosis mandates postoperative histopathologic analysis. We aimed to develop and externally validate a predictive scoring system for MV ... Full text Link to item Cite

3D Pyramid Pooling Network for Abdominal MRI Series Classification.

Journal Article IEEE Trans Pattern Anal Mach Intell · April 2022 Recognizing and organizing different series in an MRI examination is important both for clinical review and research, but it is poorly addressed by the current generation of picture archiving and communication systems (PACSs) and post-processing workstatio ... Full text Link to item Cite

Predicting Genomic Alterations of Phosphatidylinositol-3 Kinase Signaling in Hepatocellular Carcinoma: A Radiogenomics Study Based on Next-Generation Sequencing and Contrast-Enhanced CT.

Journal Article Ann Surg Oncol · March 14, 2022 BACKGROUND: Exploring the genomic landscape of hepatocellular carcinoma (HCC) provides clues for therapeutic decision-making. Phosphatidylinositol-3 kinase (PI3K) signaling is one of the key pathways regulating HCC aggressiveness, and its genomic alteratio ... Full text Link to item Cite

Deep learning-based AI model for signet-ring cell carcinoma diagnosis and chemotherapy response prediction in gastric cancer.

Journal Article Med Phys · March 2022 PURPOSE: We aimed to develop a noninvasive artificial intelligence (AI) model to diagnose signet-ring cell carcinoma (SRCC) of gastric cancer (GC) and identify patients with SRCC who could benefit from postoperative chemotherapy based on preoperative contr ... Full text Link to item Cite

Data-Driven Modification of the LI-RADS Major Feature System on Gadoxetate Disodium-Enhanced MRI: Toward Better Sensitivity and Simplicity.

Journal Article J Magn Reson Imaging · February 2022 BACKGROUND: The Liver Imaging Reporting and Data System (LI-RADS) is widely accepted as a reliable diagnostic scheme for hepatocellular carcinoma (HCC) in at-risk patients. However, its application is hampered by substantial complexity and suboptimal diagn ... Full text Link to item Cite

CT/MRI and CEUS LI-RADS Major Features Association with Hepatocellular Carcinoma: Individual Patient Data Meta-Analysis.

Journal Article Radiology · February 2022 Background The Liver Imaging Reporting and Data System (LI-RADS) assigns a risk category for hepatocellular carcinoma (HCC) to imaging observations. Establishing the contributions of major features can inform the diagnostic algorithm. Purpose To perform a ... Full text Link to item Cite

Imaging Features of Premalignant Biliary Lesions and Predisposing Conditions with Pathologic Correlation.

Journal Article Radiographics · 2022 Biliary malignancies include those arising from the intrahepatic and extrahepatic bile ducts as well as the gallbladder and hepatopancreatic ampulla of Vater. The majority of intrahepatic and extrahepatic malignancies are cholangiocarcinomas (CCAs). They a ... Full text Link to item Cite

ACR Appropriateness Criteria® Epigastric Pain.

Journal Article J Am Coll Radiol · November 2021 Epigastric pain can have multiple etiologies including myocardial infarction, pancreatitis, acute aortic syndromes, gastroesophageal reflux disease, esophagitis, peptic ulcer disease, gastritis, duodenal ulcer disease, gastric cancer, and hiatal hernia. Th ... Full text Link to item Cite

Therapies for hepatocellular carcinoma: overview, clinical indications, and comparative outcome evaluation-part one: curative intention.

Journal Article Abdominal radiology (New York) · August 2021 Hepatocellular carcinoma (HCC) offers unique management challenges as it commonly occurs in the setting of underlying chronic liver disease. The management of HCC is directed primarily by the clinical stage. The most commonly used staging system is the Bar ... Full text Cite

Artificial intelligence in assessment of hepatocellular carcinoma treatment response.

Journal Article Abdom Radiol (NY) · August 2021 Artificial Intelligence (AI) continues to shape the practice of radiology, with imaging of hepatocellular carcinoma (HCC) being of no exception. This article prepared by members of the LI-RADS Treatment Response (TR LI-RADS) work group and associates, pres ... Full text Link to item Cite

Therapies for hepatocellular carcinoma: overview, clinical indications, and comparative outcome evaluation. Part two: noncurative intention.

Journal Article Abdom Radiol (NY) · August 2021 Locoregional therapies can be offered to hepatocellular carcinoma patients as a bridge to transplant, to downstage disease burden for transplant eligibility, or for disease control to prolong survival. Systemic therapies also play a large role in HCC treat ... Full text Link to item Cite

LI-RADS treatment response algorithm for detecting incomplete necrosis in hepatocellular carcinoma after locoregional treatment: a systematic review and meta-analysis using individual patient data.

Journal Article Abdom Radiol (NY) · August 2021 PURPOSE: To perform a systematic review and meta-analysis using individual patient data to investigate the diagnostic performance of Liver Imaging Reporting and Data System (LI-RADS) Treatment Response (TR) algorithm for detecting incomplete necrosis on pa ... Full text Link to item Cite

Multisite multivendor validation of a quantitative MRI and CT compatible fat phantom.

Journal Article Med Phys · August 2021 PURPOSE: Chemical shift-encoded magnetic resonance imaging enables accurate quantification of liver fat content though estimation of proton density fat-fraction (PDFF). Computed tomography (CT) is capable of quantifying fat, based on decreased attenuation ... Full text Link to item Cite

Week 4 Liver Fat Reduction on MRI as an Early Predictor of Treatment Response in Participants with Nonalcoholic Steatohepatitis.

Journal Article Radiology · August 2021 Background Pharmacologic treatment of nonalcoholic steatohepatitis (NASH) is long term in nature; thus, early noninvasive treatment response assessment is important for therapeutic decision making. Purpose To investigate potential early predictors of the 1 ... Full text Link to item Cite

MR Imaging of Diffuse Liver Disease.

Journal Article Magn Reson Imaging Clin N Am · August 2021 The liver performs many vital functions for the human body. It stores essential vitamins and minerals, such as iron and vitamins A, D, K, and B12. It synthesizes proteins, such as blood clotting factors, albumin, and glycogen, as well as cholesterol, carbo ... Full text Link to item Cite

Temperature-corrected proton density fat fraction estimation using chemical shift-encoded MRI in phantoms.

Journal Article Magn Reson Med · July 2021 PURPOSE: Chemical shift-encoded MRI (CSE-MRI) is well-established to quantify proton density fat fraction (PDFF) as a quantitative biomarker of hepatic steatosis. However, temperature is known to bias PDFF estimation in phantom studies. In this study, stra ... Full text Link to item Cite

Missed Incidental Pulmonary Embolism: Harnessing Artificial Intelligence to Assess Prevalence and Improve Quality Improvement Opportunities.

Journal Article J Am Coll Radiol · July 2021 PURPOSE: Incidental pulmonary embolism (IPE) can be found on body CT. The aim of this study was to evaluate the feasibility of using artificial intelligence to identify missed IPE on a large number of CT examinations. METHODS: This retrospective analysis i ... Full text Link to item Cite

A structurally optimized FXR agonist, MET409, reduced liver fat content over 12 weeks in patients with non-alcoholic steatohepatitis.

Journal Article J Hepatol · July 2021 BACKGROUND & AIMS: The benefits of farnesoid X receptor (FXR) agonists in patients with non-alcoholic steatohepatitis (NASH) have been validated, although improvements in efficacy and/or tolerability remain elusive. Herein, we aimed to assess the performan ... Full text Link to item Cite

Diagnosis of LI-RADS M lesions on gadoxetate-enhanced MRI: identifying cholangiocarcinoma-containing tumor with serum markers and imaging features.

Journal Article Eur Radiol · June 2021 OBJECTIVES: The LI-RADS M (LR-M) category describes hepatic lesions probably or definitely malignant, but not specific for hepatocellular carcinoma in at-risk patients. Differentiation among LR-M entities, particularly detecting cholangiocarcinoma-containi ... Full text Link to item Cite

Prediction of Microvascular Invasion in Hepatocellular Carcinoma via Deep Learning: A Multi-Center and Prospective Validation Study.

Journal Article Cancers (Basel) · May 14, 2021 Microvascular invasion (MVI) is a critical risk factor for postoperative recurrence of hepatocellular carcinoma (HCC). Preknowledge of MVI would assist tailored surgery planning in HCC management. In this multicenter study, we aimed to explore the validity ... Full text Link to item Cite

Glycogenosis is common in nonalcoholic fatty liver disease and is independently associated with ballooning, but lower steatosis and lower fibrosis.

Journal Article Liver Int · May 2021 BACKGROUND/AIMS: Glycogen synthesis and storage are normal hepatocyte functions. However, glycogenosis, defined as excess hepatocyte glycogen visible by routine H&E light microscopy, has not been well characterized in nonalcoholic fatty liver disease (NAFL ... Full text Link to item Cite

Effects of Resmetirom on Noninvasive Endpoints in a 36-Week Phase 2 Active Treatment Extension Study in Patients With NASH.

Journal Article Hepatol Commun · April 2021 Resmetirom (MGL-3196), a selective thyroid hormone receptor-β agonist, was evaluated in a 36-week paired liver biopsy study (NCT02912260) in adults with biopsy-confirmed nonalcoholic steatohepatitis (NASH). The primary endpoint was relative liver fat reduc ... Full text Link to item Cite

How frequently does hepatocellular carcinoma develop in at-risk patients with a negative liver MRI examination with intravenous Gadobenate dimeglumine?

Journal Article Abdom Radiol (NY) · March 2021 OBJECTIVE: To determine the rate of development of clinically significant liver nodules (LR-4, LR-5, LR-M) after a negative MRI in an HCC screening population. METHODS: This retrospective study included patients at risk of developing HCC requiring imaging ... Full text Link to item Cite

Linearity and Bias of Proton Density Fat Fraction as a Quantitative Imaging Biomarker: A Multicenter, Multiplatform, Multivendor Phantom Study.

Journal Article Radiology · March 2021 Background Proton density fat fraction (PDFF) estimated by using chemical shift-encoded (CSE) MRI is an accepted imaging biomarker of hepatic steatosis. This work aims to promote standardized use of CSE MRI to estimate PDFF. Purpose To assess the accuracy ... Full text Link to item Cite

Efficacy and Safety of Aldafermin, an Engineered FGF19 Analog, in a Randomized, Double-Blind, Placebo-Controlled Trial of Patients With Nonalcoholic Steatohepatitis.

Journal Article Gastroenterology · January 2021 BACKGROUND & AIMS: Aldafermin, an engineered analog of fibroblast growth factor 19, inhibits bile acid synthesis and regulates metabolic homeostasis. We report results from a 24-week, phase 2 study, with serial liver biopsies, of patients with nonalcoholic ... Full text Link to item Cite

Online Liver Imaging Course; Pivoting to Transform Radiology Education During the SARS-CoV-2 Pandemic.

Journal Article Acad Radiol · January 2021 PURPOSE: The SARS-CoV-2 pandemic has drastically disrupted radiology in-person education. The purpose of this study was to assess the implementation of a virtual teaching method using available technology and its role in the continuity of education of prac ... Full text Link to item Cite

Deep neural networks trained for segmentation are sensitive to brightness changes: Preliminary results

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2021 Medical images of a patient may have a significantly different appearance depending on imaging modality (e.g. MRI vs. CT), sequence type (e.g., T1-weighted MRI vs. T2-weighted MRI), and even manufacturer/model of equipment used for the same modality and se ... Full text Cite

Ferumoxytol-enhanced MR Venography of the Central Veins of the Thorax for the Evaluation of Stenosis and Occlusion in Patients with Renal Impairment.

Journal Article Radiol Cardiothorac Imaging · December 2020 PURPOSE: To assess the diagnostic performance of ferumoxytol-enhanced MR venography for the detection of thoracic central vein stenosis or occlusion with conventional venography as the reference standard. MATERIALS AND METHODS: In this retrospective study, ... Full text Link to item Cite

Gadoxetate-enhanced abbreviated MRI is highly accurate for hepatocellular carcinoma screening.

Journal Article Eur Radiol · November 2020 OBJECTIVES: The primary objective was to compare the performance of 3 different abbreviated MRI (AMRI) sets extracted from a complete gadoxetate-enhanced MRI obtained for hepatocellular carcinoma (HCC) screening. Secondary objective was to perform a prelim ... Full text Link to item Cite

ACR Appropriateness Criteria® Liver Lesion-Initial Characterization.

Journal Article J Am Coll Radiol · November 2020 Incidental liver masses are commonly identified on imaging performed for other indications. Since the prevalence of benign focal liver lesions in adults is high, even in patients with primary malignancy, accurate characterization of incidentally detected l ... Full text Link to item Cite

Multicenter Validation of Association Between Decline in MRI-PDFF and Histologic Response in NASH.

Journal Article Hepatology · October 2020 BACKGROUND AND AIMS: Emerging data from a single-center study suggests that a 30% relative reduction in liver fat content as assessed by magnetic resonance imaging-proton density fat fraction (MRI-PDFF) from baseline may be associated with histologic impro ... Full text Link to item Cite

LI-RADS ancillary feature prediction of longitudinal category changes in LR-3 observations: an exploratory study.

Journal Article Abdom Radiol (NY) · October 2020 PURPOSE: To determine whether LI-RADS ancillary features predict longitudinal LR-3 observation category changes. MATERIALS AND METHODS: This exploratory, retrospective, single-center study with an independent reading center included patients who underwent ... Full text Link to item Cite

Use of Skeletal Muscle Index as a Predictor of Wait-List Mortality in Patients With End-Stage Liver Disease.

Conference Liver Transpl · September 2020 The aim of this study is to validate a proposed definition of sarcopenia in predicting wait-list mortality. We retrospectively evaluated 355 adults (age ≥18 years) with cirrhosis listed for first-time LT from January 1, 2010, to April 1, 2018 from our cent ... Full text Link to item Cite

Hepatocellular adenomas: Understanding the pathomolecular lexicon, MRI features, terminology, and pitfalls to inform a standardized approach.

Journal Article J Magn Reson Imaging · June 2020 Hepatocellular adenomas (HCAs) are benign hepatic tumors that can be complicated by bleeding and/or malignant transformation. The epidemiology of HCAs has changed over recent decades, primarily influenced by an increased incidence of obesity in both men an ... Full text Link to item Cite

ACR Appropriateness Criteria® Chronic Liver Disease.

Journal Article J Am Coll Radiol · May 2020 The liver fibrosis stage is the most important clinical determinate of morbidity and mortality in patients with chronic liver diseases. With newer therapies, liver fibrosis can be stabilized and possibly reversed, thus accurate diagnosis and staging of liv ... Full text Link to item Cite

ACR Appropriateness Criteria® Pancreatic Cyst.

Journal Article J Am Coll Radiol · May 2020 Incidental pancreatic cysts are increasingly detected on imaging studies performed for unrelated indications and may be incompletely characterized on these studies. Adequate morphological characterization is critical due to the small risk of malignant dege ... Full text Link to item Cite

NGM282 Improves Liver Fibrosis and Histology in 12 Weeks in Patients With Nonalcoholic Steatohepatitis.

Journal Article Hepatology · April 2020 NGM282, an engineered fibroblast growth factor 19 analogue, rapidly and significantly reduced liver fat content in a multicenter, randomized, double-blind, placebo-controlled study in patients with biopsy-confirmed nonalcoholic steatohepatitis (NASH). Howe ... Full text Link to item Cite

Imaging diamagnetic susceptibility of collagen in hepatic fibrosis using susceptibility tensor imaging.

Journal Article Magn Reson Med · April 2020 PURPOSE: To characterize the magnetic susceptibility changes of liver fibrosis using susceptibility tensor imaging. METHODS: Liver biopsy tissue samples of patients with liver fibrosis were obtained. Three-dimensional gradient-echo and diffusion-weighted i ... Full text Link to item Cite

The LI-RADS Version 2018 MRI Treatment Response Algorithm: Evaluation of Ablated Hepatocellular Carcinoma.

Journal Article Radiology · February 2020 Background The Liver Imaging Reporting and Data System (LI-RADS) treatment response algorithm (TRA) is used to assess presumed hepatocellular carcinoma (HCC) after local-regional therapy, but its performance has not been extensively assessed. Purpose To as ... Full text Open Access Link to item Cite

Increased Glutaminolysis Marks Active Scarring in Nonalcoholic Steatohepatitis Progression.

Journal Article Cell Mol Gastroenterol Hepatol · 2020 BACKGROUND & AIMS: Nonalcoholic steatohepatitis (NASH) occurs in the context of aberrant metabolism. Glutaminolysis is required for metabolic reprograming of hepatic stellate cells (HSCs) and liver fibrogenesis in mice. However, it is unclear how changes i ... Full text Open Access Link to item Cite

Relative Sarcopenia With Excess Adiposity Predicts Survival After Transjugular Intrahepatic Portosystemic Shunt Creation.

Journal Article AJR Am J Roentgenol · January 2020 OBJECTIVE. The purpose of this study was to assess the impact of relative sarcopenia with excess adiposity on mortality after transjugular intrahepatic portosystemic shunt (TIPS) creation. MATERIALS AND METHODS. In this single-institution retrospective stu ... Full text Link to item Cite

Deep convolutional neural network applied to the liver imaging reporting and data system (LI-RADS) version 2014 category classification: a pilot study.

Journal Article Abdom Radiol (NY) · January 2020 PURPOSE: To develop a deep convolutional neural network (CNN) model to categorize multiphase CT and MRI liver observations using the liver imaging reporting and data system (LI-RADS) (version 2014). METHODS: A pre-existing dataset comprising 314 hepatic ob ... Full text Link to item Cite

Impact of obeticholic acid on the lipoprotein profile in patients with non-alcoholic steatohepatitis.

Journal Article J Hepatol · January 2020 BACKGROUND & AIMS: Obeticholic acid (OCA), a farnesoid X receptor agonist, increases total and low-density lipoprotein cholesterol (LDL-C) in patients with non-alcoholic steatohepatitis. In the present study, we aimed to evaluate the impact of OCA therapy ... Full text Link to item Cite

The Project Baseline Health Study: a step towards a broader mission to map human health.

Journal Article NPJ Digit Med · 2020 The Project Baseline Health Study (PBHS) was launched to map human health through a comprehensive understanding of both the health of an individual and how it relates to the broader population. The study will contribute to the creation of a biomedical info ... Full text Open Access Link to item Cite

Pre-transplant hepatic steatosis (fatty liver) is associated with chronic graft-vs-host disease but not mortality.

Journal Article PLoS One · 2020 Allogeneic-HCT (allo-HCT), while potentially curative, can result in significant complications including graft versus host disease (GVHD). Prior studies suggest that metabolic syndrome may be one risk factor for GVHD. We hypothesized that hepatic steatosis ... Full text Link to item Cite

User and system pitfalls in liver imaging with LI-RADS.

Journal Article J Magn Reson Imaging · December 2019 The Liver Imaging Reporting and Data System (LI-RADS) is a comprehensive system for standardizing the terminology, technique, interpretation, reporting, and data collection of liver imaging, created specifically for patients at risk for hepatocellular carc ... Full text Link to item Cite

Multicenter Safety and Practice for Off-Label Diagnostic Use of Ferumoxytol in MRI.

Journal Article Radiology · December 2019 Background Ferumoxytol is approved for use in the treatment of iron deficiency anemia, but it can serve as an alternative to gadolinium-based contrast agents. On the basis of postmarketing surveillance data, the Food and Drug Administration issued a black ... Full text Link to item Cite

A Pilot Genome-Wide Analysis Study Identifies Loci Associated With Response to Obeticholic Acid in Patients With NASH.

Journal Article Hepatol Commun · December 2019 A significantly higher proportion of patients with nonalcoholic steatohepatitis (NASH) who received obeticholic acid (OCA) had histological improvement relative to placebo in the FLINT (farnesoid X nuclear receptor ligand obeticholic acid for noncirrhotic, ... Full text Link to item Cite

Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.

Journal Article Lancet · November 30, 2019 BACKGROUND: Non-alcoholic steatohepatitis (NASH) is characterised by hepatic steatosis, inflammation, hepatocellular injury, and progressive liver fibrosis. Resmetirom (MGL-3196) is a liver-directed, orally active, selective thyroid hormone receptor-β agon ... Full text Link to item Cite

Pre-Transplant Hepatic Steatosis (fatty liver) Predicts Chronic Graft-Vs-Host Disease but Does Not Affect Mortality

Conference Blood · November 13, 2019 Introduction: Allogeneic hematopoietic stem cell transplant (allo-HCT) remains the only curative treatment for many hematologic conditions. However, significant mortality risk and risk of severe graft-vs-host disease (GvHD) limit its usefulness. So ... Full text Cite

A North American Expert Opinion Statement on Sarcopenia in Liver Transplantation.

Journal Article Hepatology · November 2019 Loss of muscle mass and function, or sarcopenia, is a common feature of cirrhosis and contributes significantly to morbidity and mortality in this population. Sarcopenia is a main indicator of adverse outcomes in this population, including poor quality of ... Full text Link to item Cite

ACR Appropriateness Criteria® Acute Pancreatitis.

Journal Article J Am Coll Radiol · November 2019 Acute pancreatitis (AP) is divided into two types: interstitial edematous and necrotizing. AP severity is classified clinically into mild, moderately severe, and severe, depending on the presence and persistence of organ failure and local or systemic compl ... Full text Link to item Cite

Defining Improvement in Nonalcoholic Steatohepatitis for Treatment Trial Endpoints: Recommendations From the Liver Forum.

Journal Article Hepatology · November 2019 Identifying effective therapies for nonalcoholic steatohepatitis (NASH) with fibrosis is a pressing challenge, with 1%-2% of the population in developed nations at risk of developing NASH cirrhosis and its complications. The design of NASH clinical therape ... Full text Link to item Cite

Association of Histologic Disease Activity With Progression of Nonalcoholic Fatty Liver Disease.

Journal Article JAMA Netw Open · October 2, 2019 IMPORTANCE: The histologic evolution of the full spectrum of nonalcoholic fatty liver disease (NAFLD) and factors associated with progression or regression remain to be definitively established. OBJECTIVE: To evaluate the histologic evolution of NAFLD and ... Full text Link to item Cite

LI-RADS: Diagnostic Performance of Hepatobiliary Phase Hypointensity and Major Imaging Features of LR-3 and LR-4 Lesions Measuring 10-19 mm With Arterial Phase Hyperenhancement.

Journal Article AJR. American journal of roentgenology · August 2019 OBJECTIVE. The purpose of this study was to determine the diagnostic performance of hepatobiliary phase hypointensity and Liver Imaging Reporting and Data System (LI-RADS) major imaging features in the diagnosis of hepatocellular carcinoma (HCC) in ... Full text Cite

Improved accuracy of apparent diffusion coefficient quantification using a fully automatic noise bias compensation method: Preliminary evaluation in prostate diffusion weighted imaging.

Journal Article J Magn Reson · August 2019 Noise in diffusion magnetic resonance imaging can introduce bias in apparent diffusion coefficient (ADC) quantification. Previous studies proposed methods that are site-specific techniques as research tools with limited availability and typically require m ... Full text Link to item Cite

N-Acetylcysteine in the Management of Acute Liver Failure From Sickle Cell Hepatic Crisis.

Journal Article ACG Case Rep J · August 2019 N-acetylcysteine (NAC) has been well studied in the treatment of acetaminophen-induced and select non-acetaminophen-induced liver failure. However, its role in the management of sickle cell hepatic crisis resulting in acute liver failure (ALF) is unknown. ... Full text Link to item Cite

LI-RADS Treatment Response Algorithm: Performance and Diagnostic Accuracy.

Journal Article Radiology · July 2019 Background In 2017, the Liver Imaging Reporting and Data System (LI-RADS) included an algorithm for the assessment of hepatocellular carcinoma (HCC) treated with local-regional therapy. The aim of the algorithm was to enable standardized evaluation of trea ... Full text Link to item Cite

140-LB: NGM313, a Novel Activator of b-Klotho/FGFR1c, Improves Insulin Resistance and Reduces Hepatic Fat in Obese, Nondiabetic Subjects

Conference Diabetes · June 1, 2019 Background: NGM313 is a humanized monoclonal antibody activator of β-klotho/FGFR1c that has been shown to reduce HOMA-IR in obese subjects. This study compared the effects of a single dose of NGM313 vs. daily pioglitazone (PIO) on insulin sensitivi ... Full text Cite

Hepatic R2* is more strongly associated with proton density fat fraction than histologic liver iron scores in patients with nonalcoholic fatty liver disease.

Journal Article J Magn Reson Imaging · May 2019 BACKGROUND: The liver R2* value is widely used as a measure of liver iron but may be confounded by the presence of hepatic steatosis and other covariates. PURPOSE: To identify the most influential covariates for liver R2* values in patients with nonalcohol ... Full text Link to item Cite

Deep learning in radiology: An overview of the concepts and a survey of the state of the art with focus on MRI.

Journal Article J Magn Reson Imaging · April 2019 Deep learning is a branch of artificial intelligence where networks of simple interconnected units are used to extract patterns from data in order to solve complex problems. Deep-learning algorithms have shown groundbreaking performance in a variety of sop ... Full text Link to item Cite

Accurate fatty acid composition estimation of adipose tissue in the abdomen based on bipolar multi-echo MRI.

Journal Article Magn Reson Med · April 2019 PURPOSE: To develop a bipolar multi-echo MRI method for the accurate estimation of the adipose tissue fatty acid composition (FAC) using clinically relevant protocols at clinical field strength. METHODS: The proposed technique jointly estimates confounding ... Full text Link to item Cite

Applications of 3D printing in small animal magnetic resonance imaging.

Journal Article J Med Imaging (Bellingham) · April 2019 Three-dimensional (3D) printing has significantly impacted the quality, efficiency, and reproducibility of preclinical magnetic resonance imaging. It has vastly expanded the ability to produce MR-compatible parts that readily permit customization of animal ... Full text Link to item Cite

Accuracy of the Liver Imaging Reporting and Data System in Computed Tomography and Magnetic Resonance Image Analysis of Hepatocellular Carcinoma or Overall Malignancy-A Systematic Review.

Journal Article Gastroenterology · March 2019 BACKGROUND & AIMS: The Liver Imaging Reporting and Data System (LI-RADS) categorizes observations from imaging analyses of high-risk patients based on the level of suspicion for hepatocellular carcinoma (HCC) and overall malignancy. The categories range fr ... Full text Link to item Cite

Imaging-guided percutaneous thrombin injection for the treatment of iatrogenic femoral artery pseudoaneurysms.

Journal Article Abdom Radiol (NY) · March 2019 PURPOSE: To evaluate factors that may affect successful ultrasound-guided percutaneous thrombin injection of iatrogenic femoral artery pseudoaneurysms (PSA). MATERIALS AND METHODS: This was an IRB-approved, HIPAA-compliant retrospective study of 326 consec ... Full text Link to item Cite

LI-RADS: a conceptual and historical review from its beginning to its recent integration into AASLD clinical practice guidance.

Journal Article J Hepatocell Carcinoma · 2019 The Liver Imaging Reporting and Data System (LI-RADS®) is a comprehensive system for standardizing the terminology, technique, interpretation, reporting, and data collection of liver observations in individuals at high risk for hepatocellular carcinoma (HC ... Full text Link to item Cite

DIfferential Subsampling With Cartesian Ordering With Respiratory Triggering Versus Conventional Liver Acquisition With Volume Acquisition: A Multiple Reader Preference Study.

Journal Article J Comput Assist Tomogr · 2019 OBJECTIVE: The aim of this study was to compare respiratory-triggered DIfferential Subsampling with Cartesian Ordering (rtDISCO) and breath-held Liver Acquisition with Volume Acquisition (LAVA) image quality. METHODS: In this institutional review board-app ... Full text Link to item Cite

Liver Imaging Reporting and Data System (LI-RADS) Version 2018: Imaging of Hepatocellular Carcinoma in At-Risk Patients.

Journal Article Radiology · December 2018 The Liver Imaging Reporting and Data System (LI-RADS) is composed of four individual algorithms intended to standardize the lexicon, as well as reporting and care, in patients with or at risk for hepatocellular carcinoma in the context of surveillance with ... Full text Link to item Cite

CT evaluation of the renal donor and recipient.

Journal Article Abdom Radiol (NY) · October 2018 Proper pre- and post-transplant diagnostic imaging work-up is fundamental in ensuring a successful outcome for renal transplantation. Despite exposure to ionizing radiation, CT has high spatial resolution and is a widely available and fast imaging techniqu ... Full text Link to item Cite

White paper of the Society of Abdominal Radiology hepatocellular carcinoma diagnosis disease-focused panel on LI-RADS v2018 for CT and MRI.

Journal Article Abdom Radiol (NY) · October 2018 The Liver Imaging and Reporting Data System (LI-RADS) is a comprehensive system for standardizing the terminology, technique, interpretation, reporting, and data collection of liver imaging with the overarching goal of improving communication, clinical car ... Full text Link to item Cite

Spectrum of Pitfalls, Pseudolesions, and Potential Misdiagnoses in Cirrhosis.

Journal Article AJR Am J Roentgenol · July 2018 OBJECTIVE: The purposes of this article are to review a variety of pitfalls in liver imaging that can lead to the inaccurate diagnosis of focal hepatic lesions in cirrhosis, to describe the pathophysiologic processes of these pitfalls, and to provide speci ... Full text Link to item Cite

Spectrum of Pitfalls, Pseudolesions, and Misdiagnoses in Noncirrhotic Liver.

Journal Article AJR Am J Roentgenol · July 2018 OBJECTIVE: The purpose of this article is to illustrate the various pitfalls, mimics, and atypical features that can lead to inaccurate diagnosis of focal lesions in a noncirrhotic liver. The content includes relevant pathogenesis and background as well as ... Full text Link to item Cite

Mechanism of Action of the Transobturator Sling for Post-Radical Prostatectomy Incontinence: A Multi-institutional Prospective Study Using Dynamic Magnetic Resonance Imaging.

Journal Article Urology · June 2018 OBJECTIVE: To compare the length of the membranous (functional) urethra in male patients who underwent the male transobturator sling (TOS) for postradical prostatectomy urinary incontinence (PPI). The TOS is in established use for treatment of PPI; however ... Full text Link to item Cite

Comparison of Visualization Rates of LI-RADS Version 2014 Major Features With IV Gadobenate Dimeglumine or Gadoxetate Disodium in Patients at Risk for Hepatocellular Carcinoma.

Journal Article AJR Am J Roentgenol · June 2018 OBJECTIVE: The purpose of this study is to compare visualization rates of the major features covered by Liver Imaging Reporting and Data System (LI-RADS) version 2014 in patients at risk for hepatocellular carcinoma using either gadobenate dimeglumine or g ... Full text Link to item Cite

LI-RADS 2017: An update.

Journal Article J Magn Reson Imaging · June 2018 UNLABELLED: The computed tomography / magnetic resonance imaging (CT/MRI) Liver Imaging Reporting & Data System (LI-RADS) is a standardized system for diagnostic imaging terminology, technique, interpretation, and reporting in patients with or at risk for ... Full text Link to item Cite

NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.

Journal Article Lancet · March 24, 2018 BACKGROUND: Non-alcoholic steatohepatitis is a chronic liver disease characterised by the presence of hepatic steatosis, inflammation, and hepatocellular injury, for which no Food and Drug Administration (FDA)-approved treatment exists. FGF19 is a hormone ... Full text Link to item Cite

Clinical and metabolic effects associated with weight changes and obeticholic acid in non-alcoholic steatohepatitis.

Journal Article Aliment Pharmacol Ther · March 2018 BACKGROUND: In a 72-week, randomised controlled trial of obeticholic acid (OCA) in non-alcoholic steatohepatitis (NASH), OCA was superior to placebo in improving serum ALT levels and liver histology. OCA therapy also reduced weight. AIMS: Because weight lo ... Full text Link to item Cite

Linearity, Bias, and Precision of Hepatic Proton Density Fat Fraction Measurements by Using MR Imaging: A Meta-Analysis.

Journal Article Radiology · February 2018 Purpose To determine the linearity, bias, and precision of hepatic proton density fat fraction (PDFF) measurements by using magnetic resonance (MR) imaging across different field strengths, imager manufacturers, and reconstruction methods. Materials and Me ... Full text Link to item Cite

Management implications and outcomes of LI-RADS-2, -3, -4, and -M category observations.

Journal Article Abdom Radiol (NY) · January 2018 A radiologist issuing a LI-RADS category is, implicitly or explicitly, a member of a multidisciplinary team. If the definite diagnosis of a benign or malignant entity is not possible, categorizing the uncertainty as LR-2, -3, -4, or -M has important manage ... Full text Link to item Cite

Clinically Acceptable Optimized Dose Reduction in Computed Tomographic Imaging of Necrotizing Pancreatitis Using a Noise Addition Software Tool.

Journal Article J Comput Assist Tomogr · 2018 OBJECTIVE: This study aimed to determine potential radiation dose reduction of contrast-enhanced computed tomography (CECT) for imaging necrotizing pancreatitis (NP) using a noise addition tool. METHODS: Eighty-four patients were identified with at least 1 ... Full text Link to item Cite

Interreader Reliability of LI-RADS Version 2014 Algorithm and Imaging Features for Diagnosis of Hepatocellular Carcinoma: A Large International Multireader Study.

Journal Article Radiology · January 2018 Purpose To determine in a large multicenter multireader setting the interreader reliability of Liver Imaging Reporting and Data System (LI-RADS) version 2014 categories, the major imaging features seen with computed tomography (CT) and magnetic resonance ( ... Full text Link to item Cite

Free-breathing abdominal MRI improved by repeated k-t-subsampling and artifact-minimization (ReKAM).

Journal Article Med Phys · January 2018 PURPOSE: We report an approach, termed Repeated k-t-subsampling and artifact-minimization (ReKAM), for removing motion artifacts in free-breathing abdominal MRI. The method is particularly valuable for challenging patients who may not hold their breath for ... Full text Link to item Cite

Evidence Supporting LI-RADS Major Features for CT- and MR Imaging-based Diagnosis of Hepatocellular Carcinoma: A Systematic Review.

Journal Article Radiology · January 2018 The Liver Imaging Reporting and Data System (LI-RADS) standardizes the interpretation, reporting, and data collection for imaging examinations in patients at risk for hepatocellular carcinoma (HCC). It assigns category codes reflecting relative probability ... Full text Link to item Cite

LI-RADS: a glimpse into the future.

Journal Article Abdom Radiol (NY) · January 2018 This article provides a glimpse into the future of the Liver Imaging Reporting and Data System (LI-RADS), discussing the immediate and long-term plans for its continuing improvement and expansion. To complement the Core and Essentials components of the lat ... Full text Link to item Cite

Accuracy of Automated Liver Contouring, Fat Fraction, and R2* Measurement on Gradient Multiecho Magnetic Resonance Images.

Journal Article J Comput Assist Tomogr · 2018 OBJECTIVE: This study aimed to evaluate the performance of an automated workflow of volumetric liver proton density fat fraction (PDFFvol) and R2* quantification with automated inline liver volume (LV) segmentation. METHODS: Dual-echo and multiecho Dixon m ... Full text Link to item Cite

Quantitative Imaging in the Abdomen.

Journal Article Top Magn Reson Imaging · December 2017 Full text Link to item Cite

Respiratory motion artifacts during arterial phase imaging with gadoxetic acid: Can the injection protocol minimize this drawback?

Journal Article J Magn Reson Imaging · October 2017 PURPOSE: To determine which of three gadoxetic acid injection techniques best reduced the contrast-related arterial-phase motion artifacts. MATERIALS AND METHODS: This Institutional Review Board (IRB)-approved, retrospective study included a cohort of 78 c ... Full text Link to item Cite

Liver imaging reporting and data system category 4 observations in MRI: Risk factors predicting upgrade to category 5.

Journal Article J Magn Reson Imaging · September 2017 PURPOSE: To identify demographic and imaging features in magnetic resonance imaging (MRI) that are associated with upgrade of Liver Imaging Reporting and Data System (LI-RADS) category 4 (LR-4) observations to category 5 (LR-5), and to assess their effects ... Full text Link to item Cite

Structured reporting of CT enterography for inflammatory bowel disease: effect on key feature reporting, accuracy across training levels, and subjective assessment of disease by referring physicians.

Journal Article Abdom Radiol (NY) · September 2017 PURPOSE: To compare the content and accuracy of structured reporting (SR) versus non-structured reporting (NSR) for computed tomographic enterography (CTE) of inflammatory bowel disease (IBD). MATERIALS AND METHODS: This IRB-approved, HIPAA-compliant, retr ... Full text Link to item Cite

Agreement Between Magnetic Resonance Imaging Proton Density Fat Fraction Measurements and Pathologist-Assigned Steatosis Grades of Liver Biopsies From Adults With Nonalcoholic Steatohepatitis.

Journal Article Gastroenterology · September 2017 BACKGROUND & AIMS: We assessed the diagnostic performance of magnetic resonance imaging (MRI) proton density fat fraction (PDFF) in grading hepatic steatosis and change in hepatic steatosis in adults with nonalcoholic steatohepatitis (NASH) in a multi-cent ... Full text Link to item Cite

Gadolinium-based contrast agents: A comprehensive risk assessment.

Journal Article J Magn Reson Imaging · August 2017 UNLABELLED: Gadolinium-based contrast agents (GBCAs) have been used in magnetic resonance imaging (MRI) since the 1980s and are now administered in up to 35% of all MRI examinations. While GBCAs were initially felt to carry minimal risk, the subsequent ide ... Full text Link to item Cite

Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children.

Journal Article J Pediatr · August 2017 OBJECTIVES: To examine the distribution of birth weight in children with nonalcoholic fatty liver disease (NAFLD) compared with the general US population, and to investigate the relationship between birth weight and severity of NAFLD. STUDY DESIGN: A multi ... Full text Link to item Cite

Current and potential imaging applications of ferumoxytol for magnetic resonance imaging.

Journal Article Kidney Int · July 2017 Contrast-enhanced magnetic resonance imaging is a commonly used diagnostic tool. Compared with standard gadolinium-based contrast agents, ferumoxytol (Feraheme, AMAG Pharmaceuticals, Waltham, MA), used as an alternative contrast medium, is feasible in pati ... Full text Link to item Cite

Multisite, multivendor validation of the accuracy and reproducibility of proton-density fat-fraction quantification at 1.5T and 3T using a fat-water phantom.

Journal Article Magn Reson Med · April 2017 PURPOSE: To evaluate the accuracy and reproducibility of quantitative chemical shift-encoded (CSE) MRI to quantify proton-density fat-fraction (PDFF) in a fat-water phantom across sites, vendors, field strengths, and protocols. METHODS: Six sites (Philips, ... Full text Link to item Cite

Retrospective four-dimensional magnetic resonance imaging with image-based respiratory surrogate: a sagittal-coronal-diaphragm point of intersection motion tracking method.

Journal Article J Med Imaging (Bellingham) · April 2017 A four-dimensional magnetic resonance imaging (4-D-MRI) technique with Sagittal-Coronal-Diaphragm Point-of-Intersection (SCD-PoI) as a respiratory surrogate is proposed. To develop an image-based respiratory surrogate, the SCD-PoI motion tracking method is ... Full text Link to item Cite

Hepatic gadoxetic acid uptake as a measure of diffuse liver disease: Where are we?

Journal Article J Magn Reson Imaging · March 2017 UNLABELLED: MRI has emerged as the most comprehensive noninvasive diagnostic tool for focal liver lesions and diffuse hepatobiliary disorders. The introduction of hepatobiliary contrast agents, most notably gadoxetic acid (GA), has expanded the role of MRI ... Full text Link to item Cite

Comparison of ferumoxytol-enhanced MRA with conventional angiography for assessment of severity of transplant renal artery stenosis.

Journal Article J Magn Reson Imaging · March 2017 PURPOSE: To determine the accuracy of ferumoxytol-enhanced magnetic resonance angiography (MRA) in assessing the severity of transplant renal artery stenosis (TRAS), using digital subtraction angiography (DSA) as the reference standard. MATERIALS AND METHO ... Full text Link to item Cite

Intravenous Gadoxetate Disodium Administration Reduces Breath-holding Capacity in the Hepatic Arterial Phase: A Multi-Center Randomized Placebo-controlled Trial.

Journal Article Radiology · February 2017 Purpose To determine, in a multicenter double-blinded placebo-controlled trial, whether maximal hepatic arterial phase breath-holding duration is affected by gadoxetate disodium administration. Materials and Methods Institutional review board approval was ... Full text Link to item Cite

Four-dimensional diffusion-weighted MR imaging (4D-DWI): a feasibility study.

Journal Article Med Phys · February 2017 PURPOSE: Diffusion-weighted Magnetic Resonance Imaging (DWI) has been shown to be a powerful tool for cancer detection with high tumor-to-tissue contrast. This study aims to investigate the feasibility of developing a four-dimensional DWI technique (4D-DWI ... Full text Link to item Cite

Liver Imaging Reporting and Data System: an expert consensus statement.

Journal Article J Hepatocell Carcinoma · 2017 The increasing incidence and high morbidity and mortality of hepatocellular carcinoma (HCC) have inspired the creation of the Liver Imaging Reporting and Data System (LI-RADS). LI-RADS aims to reduce variability in exam interpretation, improve communicatio ... Full text Link to item Cite

Repeatability of Computerized Tomography-Based Anthropomorphic Measurements of Frailty in Patients With Pulmonary Fibrosis Undergoing Lung Transplantation.

Journal Article Curr Probl Diagn Radiol · 2017 PURPOSE: To determine interreader and intrareader repeatability and correlations among measurements of computerized tomography-based anthropomorphic measurements in patients with pulmonary fibrosis undergoing lung transplantation. METHODS: This was an inst ... Full text Link to item Cite

Effect of a Low-Rank Denoising Algorithm on Quantitative Magnetic Resonance Imaging-Based Measures of Liver Fat and Iron.

Journal Article J Comput Assist Tomogr · 2017 PURPOSE: This study aimed to assess the effect of a low-rank denoising algorithm on quantitative magnetic resonance imaging-based measures of liver fat and iron. MATERIALS AND METHODS: This was an institutional review board-approved, Health Insurance Porta ... Full text Link to item Cite

2017 Version of LI-RADS for CT and MR Imaging: An Update.

Journal Article Radiographics · 2017 The Liver Imaging Reporting and Data System (LI-RADS) is a reporting system created for the standardized interpretation of liver imaging findings in patients who are at risk for hepatocellular carcinoma (HCC). This system was developed with the cooperative ... Full text Link to item Cite

Increased parenchymal damage and steatohepatitis in Caucasian non-alcoholic fatty liver disease patients with common IL1B and IL6 polymorphisms.

Journal Article Aliment Pharmacol Ther · December 2016 BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a complex, multifactorial disease affected by diet, lifestyle and genetics. Proinflammatory cytokines like IL-1β and IL-6 have been shown to be elevated in non-alcoholic steatohepatitis (NASH). AIM: ... Full text Link to item Cite

Natural history of liver imaging reporting and data system category 4 nodules in MRI.

Journal Article Abdom Radiol (NY) · September 2016 PURPOSE: The purpose of this study was to characterize the MR imaging features and outcomes of liver imaging reporting and data system (LI-RADS) category 4 (LR4) nodules, with an emphasis on upgrade to category 5 (LR5) and development of contraindications ... Full text Link to item Cite

Stability of liver proton density fat fraction and changes in R 2* measurements induced by administering gadoxetic acid at 3T MRI.

Journal Article Abdom Radiol (NY) · August 2016 OBJECTIVE: To assess changes in liver proton density fat fraction (PDFF) and R 2* measurements in the presence of changes in tissue relaxation rates induced by administrating gadoxetic acid, using two different image reconstruction methods at 3T MRI. METHO ... Full text Link to item Cite

Diagnostic performance of MDCT in identifying closed loop small bowel obstruction.

Journal Article Abdom Radiol (NY) · July 2016 PURPOSE: To assess the diagnostic performance of MDCT in the diagnosis of closed loop small bowel obstruction. MATERIALS AND METHODS: One hundred fifty patients with CT reports including "small bowel obstruction (SBO)" between 1/30/2011 and 12/4/2012 were ... Full text Link to item Cite

How reader perception of capsule affects interpretation of washout in hypervascular liver nodules in patients at risk for hepatocellular carcinoma.

Journal Article J Magn Reson Imaging · June 2016 PURPOSE: To determine whether reader perception of a capsule affects reader interpretation of washout in hypervascular liver nodules at dynamic magnetic resonance imaging (MRI) in patients at risk for hepatocellular carcinoma (HCC). MATERIALS AND METHODS: ... Full text Link to item Cite

Can combining triple-arterial phase acquisition with fluoroscopic triggering provide both optimal early and late hepatic arterial phase images during gadoxetic acid-enhanced MRI?

Journal Article J Magn Reson Imaging · May 2016 PURPOSE: To determine whether triple-arterial phase acquisition with fluoroscopic triggering can provide both well-timed early and late hepatic arterial phase (HAP) images more frequently than when using a fixed-time delay during gadoxetic acid-enhanced ma ... Full text Link to item Cite

Safety and technique of ferumoxytol administration for MRI.

Journal Article Magn Reson Med · May 2016 Ferumoxytol is an ultrasmall superparamagnetic iron oxide agent marketed for the treatment of anemia. There has been increasing interest in its properties as an MRI contrast agent as well as greater awareness of its adverse event profile. This mini-review ... Full text Link to item Cite

Computed Tomography-Based Limb Volume Measurements for Isolated Limb Infusion in Melanoma.

Journal Article Ann Surg Oncol · April 2016 BACKGROUND: Despite advances in cross-sectional imaging, chemotherapeutic dosing for isolated limb infusion (ILI) in melanoma is currently calculated through cumbersome and potentially imprecise manual measurements. The primary objective of this study was ... Full text Link to item Cite

Consensus report from the 7th International Forum for Liver Magnetic Resonance Imaging.

Journal Article Eur Radiol · March 2016 OBJECTIVES: Liver-specific MRI is a fast-growing field, with technological and protocol advancements providing more robust imaging and allowing a greater depth of information per examination. This article reports the evidence for, and expert thinking on, c ... Full text Link to item Cite

Isolated recto-sigmoid colitis: a new imaging pattern of ipilimumab-associated colitis.

Journal Article Abdom Radiol (NY) · February 2016 PURPOSE: The purpose of this study is to describe typical CT findings and distinct imaging patterns of ipilimumab-associated colitis in immunotherapeutic treatment of melanoma. MATERIALS AND METHODS: This HIPAA-compliant retrospective study included 86 pat ... Full text Link to item Cite

Differences in Liver Imaging and Reporting Data System Categorization Between MRI and CT.

Journal Article AJR Am J Roentgenol · February 2016 OBJECTIVE: The purpose of this study is to determine whether focal liver observations are categorized differently by CT and MRI using the Liver Imaging and Reporting Data System (LI-RADS). MATERIALS AND METHODS: We performed a retrospective review of 58 pa ... Full text Link to item Cite

POCS-based reconstruction of multiplexed sensitivity encoded MRI (POCSMUSE): A general algorithm for reducing motion-related artifacts.

Journal Article Magn Reson Med · November 2015 PURPOSE: A projection onto convex sets reconstruction of multiplexed sensitivity encoded MRI (POCSMUSE) is developed to reduce motion-related artifacts, including respiration artifacts in abdominal imaging and aliasing artifacts in interleaved diffusion-we ... Full text Open Access Link to item Cite

Interexamination repeatability and spatial heterogeneity of liver iron and fat quantification using MRI-based multistep adaptive fitting algorithm.

Journal Article J Magn Reson Imaging · November 2015 PURPOSE: To assess the interexamination repeatability and spatial heterogeneity of liver iron and fat measurements using a magnetic resonance imaging (MRI)-based multistep adaptive fitting algorithm. MATERIALS AND METHODS: This prospective observational st ... Full text Link to item Cite

Magnetic resonance imaging of acute appendicitis in pregnancy: a 5-year multiinstitutional study.

Journal Article Am J Obstet Gynecol · November 2015 OBJECTIVE: The purpose of this study was to determine the diagnostic performance of magnetic resonance imaging (MRI) in the diagnosis of acute appendicitis during pregnancy in a multiinstitutional study. STUDY DESIGN: In this multicenter retrospective stud ... Full text Link to item Cite

Initial Evaluation of Four Dimensional Diffusion-Weighted MR Imaging (4D-DWI) in Phantom and Human Subject

Conference International Journal of Radiation Oncology*Biology*Physics · November 2015 Full text Cite

Diagnostic performance of imaging criteria for distinguishing autoimmune cholangiopathy from primary sclerosing cholangitis and bile duct malignancy.

Journal Article Abdom Imaging · October 2015 OBJECTIVE: To determine the diagnostic performance of imaging criteria for distinguishing Ig-G4-associated autoimmune cholangiopathy (IAC) from primary sclerosing cholangitis (PSC) and bile duct malignancy. METHODS: A medical records search between January ... Full text Link to item Cite

Imaging in Patients with Cirrhosis: Current Evidence.

Journal Article Radiol Clin North Am · September 2015 There have been major changes in the management and reporting of hepatocellular carcinoma (HCC) in the last decade. Cross-sectional imaging is now pivotal in the management of cirrhotic patients, in particular in the diagnosis and staging of HCC. Although ... Full text Link to item Cite

Concordance of hypervascular liver nodule characterization between the organ procurement and transplant network and liver imaging reporting and data system classifications.

Journal Article J Magn Reson Imaging · August 2015 PURPOSE: To determine the rate of agreement between the Organ Procurement and Transplant Network (OPTN) and Liver Imaging Reporting and Data System (LI-RADS) classifications for hypervascular liver nodules at least 1 cm in diameter, and for patient eligibi ... Full text Link to item Cite

T2-weighted four dimensional magnetic resonance imaging with result-driven phase sorting.

Journal Article Med Phys · August 2015 PURPOSE: T2-weighted MRI provides excellent tumor-to-tissue contrast for target volume delineation in radiation therapy treatment planning. This study aims at developing a novel T2-weighted retrospective four dimensional magnetic resonance imaging (4D-MRI) ... Full text Link to item Cite

Image-guided percutaneous drainage vs. surgical repair of gastrointestinal anastomotic leaks: is there a difference in hospital course or hospitalization cost?

Journal Article Abdom Imaging · June 2015 PURPOSE: To identify differences in hospital course and hospitalization cost when comparing image-guided percutaneous drainage with surgical repair for gastrointestinal anastomotic leaks. MATERIALS AND METHODS: A retrospective IRB-approved search using key ... Full text Link to item Cite

Computer-aided liver volumetry: performance of a fully-automated, prototype post-processing solution for whole-organ and lobar segmentation based on MDCT imaging.

Journal Article Abdom Imaging · June 2015 PURPOSE: To evaluate the performance of a prototype, fully-automated post-processing solution for whole-liver and lobar segmentation based on MDCT datasets. MATERIALS AND METHODS: A polymer liver phantom was used to assess accuracy of post-processing appli ... Full text Link to item Cite

TH-CD-207-09: Retrospective 4D-MRI with a Novel Image-Based Surrogate: A Sagittal-Coronal-Diaphragm Point of Intersection (SCD-PoI) Motion Tracking Method.

Journal Article Med Phys · June 2015 PURPOSE: The unreliable stability of internal respiratory surrogates and inconvenience of external respiratory surrogates for current retrospective 4D-MRI techniques largely affects the image quality of 4D-MRI. This study aims at developing image-based sur ... Full text Link to item Cite

SU-F-303-13: Initial Evaluation of Four Dimensional Diffusion- Weighted MRI (4D-DWI) and Its Effect On Apparent Diffusion Coefficient (ADC) Measurement.

Journal Article Med Phys · June 2015 PURPOSE: Diffusion-weighted imaging(DWI) has been shown to have superior tumor-to-tissue contrast for cancer detection.This study aims at developing and evaluating a four dimensional DWI(4D-DWI) technique using retrospective sorting method for imaging resp ... Full text Link to item Cite

Effect of anisotropic dust pressure and superthermal electrons on propagation and stability of dust acoustic solitary waves

Journal Article Physics of Plasmas · June 1, 2015 Employing the reductive perturbation technique, Zakharov-Kuznetzov (ZK) equation is derived for dust acoustic (DA) solitary waves in a magnetized plasma which consists the effects of dust anisotropic pressure, arbitrary charged dust particles, Boltzmann di ... Full text Cite

Correlation between quantitative whole-body muscle magnetic resonance imaging and clinical muscle weakness in Pompe disease.

Journal Article Muscle Nerve · May 2015 INTRODUCTION: Previous examination of whole-body muscle involvement in Pompe disease has been limited to physical examination and/or qualitative magnetic resonance imaging (MRI). In this study we assess the feasibility of quantitative proton-density fat-fr ... Full text Open Access Link to item Cite

On confirmation bias in imaging research.

Journal Article J Magn Reson Imaging · May 2015 Full text Link to item Cite

Advanced magnetic resonance techniques: 3 T.

Journal Article Radiol Clin North Am · May 2015 Magnetic resonance (MR) imaging at 3 T is clinically feasible and, in the right context, can provide improvements compared with 1.5-T MR imaging. Improvements in both signal/noise ratio and contrast/noise ratio can be used to improve image homogeneity and/ ... Full text Link to item Cite

Trust in automation: integrating empirical evidence on factors that influence trust.

Journal Article Hum Factors · May 2015 OBJECTIVE: We systematically review recent empirical research on factors that influence trust in automation to present a three-layered trust model that synthesizes existing knowledge. BACKGROUND: Much of the existing research on factors that guide human-au ... Full text Link to item Cite

Effects of the organic additives on dental zirconia ceramics: structural and mechanical properties

Conference Journal of Sol-Gel Science and Technology · May 1, 2015 Zirconia ceramics have gained lot of interest as restorative materials because of remarkable mechanical properties; such as high strength and toughness, good biocompatibility, and aesthetic properties. But the problem with zirconia is inertness with the bo ... Full text Cite

Synthesis of stabilized zirconia hollow nanoparticles: sugar as a template

Conference Journal of Sol-Gel Science and Technology · May 1, 2015 Hollow zirconia (HZ) nanoparticles (NPs) are synthesized by a simple, versatile, and an efficient methodology based on sol–gel technique. Before gelation, zirconia sols of different molarities are treated ultrasonically for 10 min with sugar as a template. ... Full text Cite

Fe3O4 stabilized zirconia: structural, mechanical and optical properties

Conference Journal of Sol-Gel Science and Technology · May 1, 2015 Zirconia (ZrO2) is one of the most well studied transition-metal oxides in the optical and biological fields. The applications area of ZrO2 can be increased by addition of metal oxides. Aim of this study is to determine the effect of acidic and basic Fe3O4 ... Full text Cite

Effect of Vitamin D supplementation on glycemic parameters and progression of prediabetes to diabetes: A 1-year, open-label randomized study

Journal Article Indian Journal of Endocrinology and Metabolism · May 1, 2015 Background: Whether Vitamin D supplementation in prediabetes subjects prevents the development of diabetes is a matter of debate, and the results are inconsistent. This open-label, randomized study in subjects with prediabetes evaluated the effect of 12 mo ... Full text Cite

Emerging applications for ferumoxytol as a contrast agent in MRI.

Journal Article J Magn Reson Imaging · April 2015 Ferumoxytol is an ultrasmall superparamagnetic iron oxide (USPIO) agent initially approved by the Food and Drug Administration (FDA) as an iron replacement therapy for patients with anemia due to chronic renal failure. Recently, ferumoxytol has been invest ... Full text Link to item Cite

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial.

Journal Article Lancet · March 14, 2015 BACKGROUND: The bile acid derivative 6-ethylchenodeoxycholic acid (obeticholic acid) is a potent activator of the farnesoid X nuclear receptor that reduces liver fat and fibrosis in animal models of fatty liver disease. We assessed the efficacy of obeticho ... Full text Link to item Cite

Interdependencies of acquisition, detection, and reconstruction techniques on the accuracy of iodine quantification in varying patient sizes employing dual-energy CT.

Journal Article Eur Radiol · March 2015 PURPOSE: To assess the impact of patient habitus, acquisition parameters, detector efficiencies, and reconstruction techniques on the accuracy of iodine quantification using dual-source dual-energy CT (DECT). MATERIALS AND METHODS: Two phantoms simulating ... Full text Link to item Cite

Diagnostic per-patient accuracy of an abbreviated hepatobiliary phase gadoxetic acid-enhanced MRI for hepatocellular carcinoma surveillance.

Journal Article AJR Am J Roentgenol · March 2015 OBJECTIVE. The purpose of this study is to evaluate the per-patient diagnostic performance of an abbreviated gadoxetic acid-enhanced MRI protocol for hepatocellular carcinoma (HCC) surveillance. MATERIALS AND METHODS. A retrospective review identified 298 ... Full text Link to item Cite

Quantification of hepatic steatosis with a multistep adaptive fitting MRI approach: prospective validation against MR spectroscopy.

Journal Article AJR Am J Roentgenol · February 2015 OBJECTIVE. The purpose of this study is to prospectively compare hybrid and complex chemical shift-based MRI fat quantification methods against MR spectroscopy (MRS) for the measurement of hepatic steatosis. SUBJECTS AND METHODS. Forty-two subjects (18 men ... Full text Link to item Cite

Respiratory-gated noncontrast SPACE MR angiography sequence at 3T for evaluation of the central veins of the chest: a feasibility study.

Journal Article J Magn Reson Imaging · January 2015 PURPOSE: To evaluate the feasibility of a respiratory-gated noncontrast magnetic resonance angiography (MRA) sequence for imaging the central veins of the chest. MATERIALS AND METHODS: Eleven healthy subjects underwent MRA of the central veins of the chest ... Full text Link to item Cite

Respiratory motion artifact affecting hepatic arterial phase MR imaging with gadoxetate disodium is more common in patients with a prior episode of arterial phase motion associated with gadoxetate disodium.

Journal Article Radiology · January 2015 PURPOSE: To determine, in a dual-center setting, whether patients who experience transient severe motion ( TSM transient severe motion ) in the arterial phase during gadoxetate disodium-enhanced magnetic resonance (MR) imaging are at higher risk for a subs ... Full text Link to item Cite

Graft Kidney Torsion After Simultaneous Kidney-Pancreas Transplant: Report of 2 Cases and Literature Review.

Journal Article J Comput Assist Tomogr · 2015 Torsion of an allograft kidney is an extremely rare and potentially reversible complication. Imaging diagnosis plays a crucial role because of the absence of specific clinical features. We report 2 cases in which kidney torsion after simultaneous kidney-pa ... Full text Link to item Cite

Effect of Glomus mosseae (Gerd and Trappe) and neemex® against Meloidogyne incognita (Kofoid and White) chitwood on eggplant

Journal Article Pakistan Journal of Zoology · January 1, 2015 An experiment was conducted to formulate a strategy for the management of root-knot nematode, (Meloidogyne incognita) on eggplant under field conditions by mycorrhizal fungus (Glomus mosseae) and neemex®(Azadirachtin) alone and in combination. Eggplant see ... Cite

Is diaphragm motion a good surrogate for liver tumor motion?

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2014 PURPOSE: To evaluate the relationship between liver tumor motion and diaphragm motion. METHODS AND MATERIALS: Fourteen patients with hepatocellular carcinoma (10 of 14) or liver metastases (4 of 14) undergoing radiation therapy were included in this study. ... Full text Link to item Cite

Liver fat quantification using a multi-step adaptive fitting approach with multi-echo GRE imaging.

Journal Article Magn Reson Med · November 2014 PURPOSE: The purpose of this study was to develop a multi-step adaptive fitting approach for liver proton density fat fraction (PDFF) and R(2)* quantification, and to perform an initial validation on a broadly available hardware platform. THEORY AND METHOD ... Full text Link to item Cite

CME update: review articles and commentaries in JMRI.

Journal Article J Magn Reson Imaging · October 2014 Full text Link to item Cite

Investigation of sagittal image acquisition for 4D-MRI with body area as respiratory surrogate.

Journal Article Med Phys · October 2014 PURPOSE: The authors have recently developed a novel 4D-MRI technique for imaging organ respiratory motion employing cine acquisition in the axial plane and using body area (BA) as a respiratory surrogate. A potential disadvantage associated with axial ima ... Full text Link to item Cite

Dose-toxicity relationship of gadoxetate disodium and transient severe respiratory motion artifact.

Journal Article AJR Am J Roentgenol · October 2014 OBJECTIVE: The purpose of this article is to determine whether there is a dose-toxicity relationship between gadoxetate disodium and transient severe respiratory motion artifact. MATERIALS AND METHODS: Gadoxetate disodium-enhanced MRI studies (559 studies ... Full text Link to item Cite

Magnetic resonance contrast agents for liver imaging.

Journal Article Magn Reson Imaging Clin N Am · August 2014 Intravenous contrast agents are important in the performance of liver magnetic resonance (MR) imaging. These agents differ in their physical properties. These differences can be exploited to optimize imaging protocols based on indications for examination. ... Full text Link to item Cite

Iron deficiency in patients with nonalcoholic Fatty liver disease is associated with obesity, female gender, and low serum hepcidin.

Journal Article Clin Gastroenterol Hepatol · July 2014 BACKGROUND & AIMS: Iron deficiency is often observed in obese individuals. The iron regulatory hormone hepcidin is regulated by iron and cytokines interleukin (IL) 6 and IL1β. We examine the relationship between obesity, circulating levels of hepcidin, and ... Full text Link to item Cite

Retrospective assessment of the utility of an iron-based agent for contrast-enhanced magnetic resonance venography in patients with endstage renal diseases.

Journal Article J Magn Reson Imaging · July 2014 PURPOSE: To compare abdominopelvic and lower extremity venous enhancement in contrast-enhanced magnetic resonance venography (ceMRV), using iron-based ferumoxytol and gadolinium-based gadofosveset. MATERIALS AND METHODS: This was a Health Insurance Portabi ... Full text Link to item Cite

High variability in radiologists' reporting practices for incidental thyroid nodules detected on CT and MRI.

Journal Article AJNR Am J Neuroradiol · June 2014 BACKGROUND AND PURPOSE: There are no guidelines for reporting incidental thyroid nodules seen on CT and MR imaging. We evaluated radiologists' current reporting practices for incidental thyroid nodules detected on these imaging modalities. MATERIALS AND ME ... Full text Link to item Cite

Vascular artifact mimicking thrombosis on MR imaging using ferumoxytol as a contrast agent in abdominal vascular assessment.

Journal Article J Vasc Interv Radiol · June 2014 PURPOSE: To describe an artifact that mimics thrombosis when assessing abdominal vasculature on magnetic resonance (MR) imaging using ferumoxytol in patients with contraindications to gadolinium-based contrast agents and to evaluate factors that may contri ... Full text Link to item Cite

Optimal timing and diagnostic adequacy of hepatocyte phase imaging with gadoxetate-enhanced liver MRI.

Journal Article Acad Radiol · June 2014 RATIONALE AND OBJECTIVES: To evaluate clinical and imaging features associated with adequacy of the hepatocyte phase (HP) in gadoxetate disodium-enhanced liver magnetic resonance imaging (MRI) in patients without chronic liver disease (CLD). MATERIALS AND ... Full text Link to item Cite

Safety of an intercostal approach for imaging-guided percutaneous drainage of subdiaphragmatic abscesses.

Journal Article AJR Am J Roentgenol · June 2014 OBJECTIVE: The objective of our study was to test the hypothesis that an intercostal approach to imaging-guided percutaneous subdiaphragmatic abscess drainage is as safe as a subcostal approach. MATERIALS AND METHODS: A cohort of 258 consecutive patients w ... Full text Link to item Cite

MO-G-18C-04: Improved Synthetic 4D-MRI Using Linear Polynomial Fitting Model.

Journal Article Med Phys · June 2014 PURPOSE: To reduce deformable image registration error by fitting the displacement vector field (DVF) to smooth the motion trajectory of each pixel in synthetic 4D-MRI. METHODS: Five patients with cancers in the liver were enrolled in this study. For a 4D ... Full text Link to item Cite

MO-C-17A-02: A Novel Method for Evaluating Hepatic Stiffness Based On 4D-MRI and Deformable Image Registration.

Journal Article Med Phys · June 2014 PURPOSE: Quantitative imaging of hepatic stiffness has significant potential in radiation therapy, ranging from treatment planning to response assessment. This study aims to develop a novel, noninvasive method to quantify liver stiffness with 3D strains li ... Full text Link to item Cite

SU-E-J-68: Evaluation of Liver Deformation During Breathing Using Deformable Image Registration: A Comparison Between 4D CT and 4D MRI.

Journal Article Med Phys · June 2014 PURPOSE: It is of clinical interest to study liver deformation during breathing by applying deformable image registration (DIR) on respiratory correlated 4D images. This study aims to evaluate and compare the accuracy of DIR-derived liver deformation based ... Full text Link to item Cite

WE-G-18C-06: Is Diaphragm Motion a Good Surrogate for Liver Tumor Motion?

Journal Article Med Phys · June 2014 PURPOSE: To investigate whether diaphragm motion is a good surrogate for liver tumor motion by comparing their motion trajectories obtained from cine-MRI. METHODS: Fourteen patients with hepatocellular carcinoma (10/14) or liver metastases (4/14) undergoin ... Full text Link to item Cite

Current opinions on medical radiation: a survey of oncologists regarding radiation exposure and dose reduction in oncology patients.

Journal Article J Am Coll Radiol · May 2014 PURPOSE: The aim of this study was to evaluate oncologists' opinions about the use of ionizing radiation in medical imaging of oncology patients. METHODS: An electronic survey was e-mailed to 2,725 oncologists at the top 50 National Cancer Institute-funded ... Full text Link to item Cite

Respiratory motion artifact affecting hepatic arterial phase imaging with gadoxetate disodium: examination recovery with a multiple arterial phase acquisition.

Journal Article Radiology · May 2014 PURPOSE: To determine whether the use of a multiple arterial phase imaging technique provides adequate image quality in patients experiencing transient severe motion (TSM) in the arterial phase on abdominal magnetic resonance (MR) images obtained with gado ... Full text Link to item Cite

Impact of precontrast T10 relaxation times on dynamic contrast-enhanced MRI pharmacokinetic parameters: T10 mapping versus a fixed T10 reference value.

Journal Article J Magn Reson Imaging · May 2014 PURPOSE: To investigate variation in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) pharmacokinetic parameter measurements between different methods of precontrast tissue relaxation (T10) estimation: pixel-based mapping versus a fixed refer ... Full text Link to item Cite

Four-dimensional magnetic resonance imaging using axial body area as respiratory surrogate: initial patient results.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2014 PURPOSE: To evaluate the feasibility of a retrospective binning technique for 4-dimensional magnetic resonance imaging (4D-MRI) using body area (BA) as a respiratory surrogate. METHODS AND MATERIALS: Seven patients with hepatocellular carcinoma (4 of 7) or ... Full text Link to item Cite

Contrast-enhanced free-breathing 3D T1-weighted gradient-echo sequence for hepatobiliary MRI in patients with breath-holding difficulties.

Journal Article Eur Radiol · November 2013 OBJECTIVE: Evaluate the image quality and diagnostic performance of a free-breathing 3D-gradient-echo sequence with radial acquisition (rGRE) compared with a Cartesian breath-hold 3D-GRE (cGRE) sequence on hepatobiliary phase MRI in patients with breath-ho ... Full text Link to item Cite

Is follow-up CT imaging of the chest and abdomen necessary after preoperative neoadjuvant therapy in rectal cancer patients without evidence of metastatic disease at diagnosis?

Journal Article Colorectal Dis · November 2013 AIM: Patients with rectal cancer often undergo multiple CT scans prior to surgical resection. We propose that in patients with locally advanced rectal cancer without evidence of metastatic disease at presentation, CT imaging of the chest and abdomen after ... Full text Link to item Cite

4D-MRI Using Sagittal Acquisition and Body Area as Respiratory Surrogate

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Automated patient-tailored screening of the liver for diffuse steatosis and iron overload using MRI.

Journal Article AJR Am J Roentgenol · September 2013 OBJECTIVE: The purpose of this article is to validate an automated screening method for evaluation of hepatic steatosis or siderosis. MATERIALS AND METHODS: This was a two-part study, with retrospective and prospective portions. First, 130 consecutive abdo ... Full text Link to item Cite

Inter- and intra-rater reproducibility of quantitative dynamic contrast enhanced MRI using TWIST perfusion data in a uterine fibroid model.

Journal Article J Magn Reson Imaging · August 2013 PURPOSE: To determine the reproducibility of TWIST-derived (Time-Resolved Angiography with Interleaved Stochastic Trajectories) quantitative dynamic contrast enhanced (DCE) MRI in a uterine fibroid model. MATERIALS AND METHODS: The institutional review boa ... Full text Link to item Cite

Generating color-coded anatomic muscle maps for correlation of quantitative magnetic resonance imaging analysis with clinical examination in neuromuscular disorders.

Journal Article Muscle Nerve · August 2013 INTRODUCTION: Fatty infiltration of muscles may be seen in many neuromuscular disorders, including glycogen storage disease (GSD), muscular dystrophy, and amyotrophic lateral sclerosis. Recording pathologic involvement of musculature in these patients is c ... Full text Link to item Cite

Renal transplant imaging using magnetic resonance angiography with a nonnephrotoxic contrast agent.

Journal Article Transplantation · July 15, 2013 BACKGROUND: In renal allograft recipients presenting with graft dysfunction, it is critical to determine the patency of the transplant vasculature to guide clinical management. Conventional modalities such as Doppler ultrasound, contrast-enhanced computed ... Full text Link to item Cite

MRI assessment of biliary ductal obstruction: is there added value of T1-weighted gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced MR cholangiography?

Journal Article AJR Am J Roentgenol · July 2013 OBJECTIVE: The goal of the present study was to determine the added value of gadolium-ethoxybenzyl-diethylenetriamine pentaacetic acid (gadoxetate disodium)-enhanced magnetic resonance cholangiography (MRC) to standard liver MRI including T2-weighted MRCP ... Full text Link to item Cite

TU-G-134-01: 4D-MRI Using Body Area as Internal Respiratory Surrogate: Initial Patient Results.

Journal Article Med Phys · June 2013 PURPOSE: We have previously developed a novel 4D-MRI technique using body area (BA) as internal respiratory surrogate. This study is to demonstrate our initial patient results via validating the accuracy of tumor motion measurements and the improvement of ... Full text Link to item Cite

TH-C-141-07: T2-Weighted 4D-MRI with Combined Phase and Amplitude Sorting.

Journal Article Med Phys · June 2013 PURPOSE: T2-weighted MR provides excellent delineation of malignant liver lesions due to its superior tumor-to-tissue contrast. This study aims to develop a novel T2-weighted retrospective 4D-MRI technique for imaging organ/tumor respiratory motion with im ... Full text Link to item Cite

WE-C-116-07: Tumor Enhancement Using Deformable Image Registration for Four-Dimensional Magnetic Resonance Imaging (4D-MRI): A Feasibility Study.

Journal Article Med Phys · June 2013 PURPOSE: We have previously developed a 4D-MRI technique using the fast imaging sequence employing steady-state acquisition (FIESTA) sequence, which has suboptimal tumor-to-tissue contrast-to-noise ratio (CNR) due to its T2*/T1 weighting. This study invest ... Full text Link to item Cite

Lesion detection and assessment of extrahepatic findings in abdominal MRI using hepatocyte specific contrast agents--comparison of Gd-EOB-DTPA and Gd-BOPTA.

Journal Article BMC Med Imaging · March 18, 2013 BACKGROUND: To evaluate the contrast agent performance of Gd-EOB-DTPA and Gd-BOPTA for detection and assessment of extrahepatic findings, semi-quantitatively and qualitatively. METHODS: 13 patients with 19 extrahepatic lesions underwent liver MRI with Gd-E ... Full text Link to item Cite

Reproducibility of dynamic contrast-enhanced MR imaging. Part II. Comparison of intra- and interobserver variability with manual region of interest placement versus semiautomatic lesion segmentation and histogram analysis.

Journal Article Radiology · March 2013 PURPOSE: To compare the inter- and intraobserver variability with manual region of interest (ROI) placement versus that with software-assisted semiautomatic lesion segmentation and histogram analysis with respect to quantitative dynamic contrast material-e ... Full text Link to item Cite

Reproducibility of dynamic contrast-enhanced MR imaging. Part I. Perfusion characteristics in the female pelvis by using multiple computer-aided diagnosis perfusion analysis solutions.

Journal Article Radiology · March 2013 PURPOSE: To test the reproducibility of model-derived quantitative and semiquantitative pharmacokinetic parameters among various commercially available perfusion analysis solutions for dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imagin ... Full text Link to item Cite

Quantitative dynamic contrast-enhanced MRI of pelvic and lumbar bone marrow: effect of age and marrow fat content on pharmacokinetic parameter values.

Journal Article AJR Am J Roentgenol · March 2013 OBJECTIVE: The purpose of this study was to determine the effects of age and fat content on quantitative dynamic contrast-enhanced MRI (DCE-MRI) parameters in the bone marrow of the lumbar spine and pelvis. The interreader reproducibility of this technique ... Full text Link to item Cite

Hepatocellular carcinoma in a North American population: does hepatobiliary MR imaging with Gd-EOB-DTPA improve sensitivity and confidence for diagnosis?

Journal Article J Magn Reson Imaging · February 2013 PURPOSE: To evaluate the value of hepatobiliary phase imaging for detection and characterization of hepatocellular carcinoma (HCC) in liver MRI with Gd-EOB-DTPA, in a North American population. MATERIALS AND METHODS: One hundred MRI examinations performed ... Full text Link to item Cite

Bone marrow enhancement during time-resolved magnetic resonance angiography of the pelvis.

Journal Article J Comput Assist Tomogr · 2013 OBJECTIVE: This study aimed to determine whether visible bone marrow enhancement (BME) at pelvic magnetic resonance angiography (MRA) correlates with anemia. METHODS: This is an institutional review board-approved, Health Insurance Portability and Accounta ... Full text Link to item Cite

Gadofosveset-enhanced magnetic resonance angiography of the thoracic vasculature in the equilibrium phase: feasibility and impact of dose.

Journal Article J Comput Assist Tomogr · 2013 OBJECTIVE: The objectives of this study were to evaluate the feasibility of gadofosveset-enhanced magnetic resonance angiography (MRA) of the thoracic vasculature in the equilibrium phase and to determine the impact of gadofosveset dose on imaging quality. ... Full text Link to item Cite

Bulbar muscle weakness and fatty lingual infiltration in glycogen storage disorder type IIIa.

Journal Article Mol Genet Metab · November 2012 Featured Publication Glycogen storage disorder type III (GSD III) is a rare autosomal recessive disorder resulting from a deficiency of glycogen debranching enzyme, critical in cytosolic glycogen degradation. GSD IIIa, the most common form of GSD III, primarily affects the liv ... Full text Open Access Link to item Cite

Iodine quantification using dual-energy multidetector computed tomography imaging: phantom study assessing the impact of iterative reconstruction schemes and patient habitus on accuracy.

Journal Article Invest Radiol · November 2012 Featured Publication PURPOSE: The aim of this study was to assess the accuracy of iodine quantification based on spectral dual-energy computed tomography (DECT) extraction with additional noise reduction using iterative reconstruction in simulated optimal and obese patient env ... Full text Link to item Cite

Gradient shimming during magnetic resonance imaging of the liver: comparison of a standard protocol versus a novel reduced protocol.

Journal Article Invest Radiol · September 2012 Featured Publication PURPOSE: The aim of this study was to examine the effect of minimizing prescan adjustments on table time and image quality in magnetic resonance imaging (MRI) of the liver. MATERIALS AND METHODS: This prospective Health Insurance Portability and Accountabi ... Full text Link to item Cite

Improved aortic enhancement in CT angiography using slope-based triggering with table speed optimization: a pilot study.

Journal Article Int J Cardiovasc Imaging · August 2012 Featured Publication To assess whether a scan triggering technique based on the slope of the time-attenuation curve combined with table speed optimization may improve arterial enhancement in aortic CT angiography compared to conventional threshold-based triggering techniques. ... Full text Link to item Cite

Radiation dose reduction in abdominal computed tomography during the late hepatic arterial phase using a model-based iterative reconstruction algorithm: how low can we go?

Journal Article Invest Radiol · August 2012 Featured Publication OBJECTIVE: The aim of this study was to compare the image quality of abdominal computed tomography scans in an anthropomorphic phantom acquired at different radiation dose levels where each raw data set is reconstructed with both a standard convolution fil ... Full text Link to item Cite

MDCT evaluation of the pancreas: nuts and bolts.

Journal Article Radiol Clin North Am · May 2012 Featured Publication Multidetector-row CT (MDCT) imaging of the pancreas has important roles in diagnosis, staging, and treatment monitoring of a vast array of pancreatic diseases. Optimizing MDCT protocols not only requires an understanding of expected pathologies but also mu ... Full text Link to item Cite

Automated liver sampling using a gradient dual-echo Dixon-based technique.

Journal Article Magn Reson Med · May 2012 Featured Publication Magnetic resonance spectroscopy of the liver requires input from a physicist or physician at the time of acquisition to insure proper voxel selection, while in multiecho chemical shift imaging, numerous regions of interest must be manually selected in orde ... Full text Link to item Cite

Liver MRI in the hepatocyte phase with gadolinium-EOB-DTPA: does increasing the flip angle improve conspicuity and detection rate of hypointense lesions?

Journal Article J Magn Reson Imaging · March 2012 Featured Publication PURPOSE: To compare conspicuity and detection rate of hypointense lesions on T1-weighted (T1w) gradient echo (GRE) sequences with low and high flip angles (FA) in hepatocyte phase magnetic resonance imaging (MRI) using gadoxetate disodium. MATERIALS AND ME ... Full text Link to item Cite

Assessing disease severity in Pompe disease: the roles of a urinary glucose tetrasaccharide biomarker and imaging techniques.

Journal Article Am J Med Genet C Semin Med Genet · February 15, 2012 Featured Publication Defining disease severity in patients with Pompe disease is important for prognosis and monitoring the response to therapies. Current approaches include qualitative and quantitative assessments of the disease burden, and clinical measures of the impact of ... Full text Link to item Cite

Hepatic MR imaging for in vivo differentiation of steatosis, iron deposition and combined storage disorder: single-ratio in/opposed phase analysis vs. dual-ratio Dixon discrimination.

Journal Article Eur J Radiol · February 2012 Featured Publication OBJECTIVE: To assess whether in vivo dual-ratio Dixon discrimination can improve detection of diffuse liver disease, specifically steatosis, iron deposition and combined disease over traditional single-ratio in/opposed phase analysis. METHODS: Seventy-one ... Full text Link to item Cite

Contrast-enhanced magnetic resonance angiography: first-pass arterial enhancement as a function of gadolinium-chelate concentration, and the saline chaser volume and injection rate.

Journal Article Invest Radiol · February 2012 Featured Publication OBJECTIVE: To evaluate the effect of the contrast medium (CM) concentration and the saline chaser volume and injection rate on first-pass aortic enhancement characteristics in contrast-enhanced magnetic resonance angiography using a physiologic flow phanto ... Full text Link to item Cite

Diagnostic accuracy of intra-abdominal fluid collection characterization in the era of multidetector computed tomography.

Journal Article Am Surg · February 2012 Featured Publication The purpose of this study was to test the hypothesis that with improved technology, the presence of abscess in a postoperative fluid collection may be prospectively made. This is an Institutional Review Board-approved, Health Insurance Portability and Acco ... Link to item Cite

Rate of contrast material extravasations and allergic-like reactions: effect of extrinsic warming of low-osmolality iodinated CT contrast material to 37 degrees C.

Journal Article Radiology · February 2012 PURPOSE: To retrospectively determine whether extrinsic warming of the low-osmolality contrast material iopamidol to 37°C prior to intravenous administration at computed tomography (CT) affects extravasation and allergic-like reaction rates. MATERIALS AND ... Full text Link to item Cite

Effectiveness of a three-dimensional dual gradient echo two-point Dixon technique for the characterization of adrenal lesions at 3 Tesla.

Journal Article Eur Radiol · January 2012 Featured Publication OBJECTIVE: To compare the sensitivity, specificity, and diagnostic accuracy of fat-only datasets reconstructed using a two-point Dixon technique, with corresponding opposed-phase (OP) and in-phase (IP) datasets for characterization of adrenal lesions at 3 ... Full text Link to item Cite

Effectiveness of a breath-hold monitoring system in improving the reproducibility of different breath-hold positions in multiphasic CT imaging.

Journal Article Clin Imaging · 2012 Featured Publication This study tests whether the utilization of an electronic breath-hold monitoring device improves breath-hold reproducibility during computed tomographic (CT) scanning. Two cohorts of 40 patients underwent dual-phase abdominal CT scans, either with a breath ... Full text Link to item Cite

White paper from the ACR Task Force on Print Media in Radiology.

Journal Article J Am Coll Radiol · October 2011 Featured Publication The rapidly changing technological and business environment in which scientific journals are published will necessitate ongoing reassessment of operations, goals, and priorities. In this white paper, the ACR Task Force on Print Media in Radiology reviews t ... Full text Link to item Cite

Imaging-guided preoperative hookwire localization of nonpalpable extramammary lesions.

Journal Article AJR Am J Roentgenol · September 2011 Featured Publication OBJECTIVE: Imaging-guided hookwire localization of nonpalpable lesions in the breast is frequently performed preoperatively. Outside the breast, this procedure is useful for planning resection of lesions in anatomic regions without intrinsic landmarks. The ... Full text Link to item Cite

Global health training in radiology residency programs.

Journal Article Acad Radiol · June 2011 Featured Publication RATIONALE AND OBJECTIVES: To measure perceptions of radiology residents regarding the imaging needs of the developing world and the potential role of an organized global health imaging curriculum during residency training. MATERIALS AND METHODS: An electro ... Full text Link to item Cite

Effect of organ enhancement and habitus on estimation of unenhanced attenuation at contrast-enhanced dual-energy MDCT: concepts for individualized and organ-specific spectral iodine subtraction strategies.

Journal Article AJR Am J Roentgenol · May 2011 Featured Publication OBJECTIVE: The purpose of this study was to assess whether habitus and organ enhancement influence iodine subtraction and should be incorporated into spectral subtraction algorithms. SUBJECTS AND METHODS: This study included 171 patients. In the unenhanced ... Full text Link to item Cite

Improved liver lesion conspicuity by increasing the flip angle during hepatocyte phase MR imaging.

Journal Article Eur Radiol · February 2011 Featured Publication OBJECTIVE: One of the advantages of using hepatobiliary contrast agents in liver MRI is the ability to acquire a delayed, "hepatocyte phase" dataset. This phase highlights many types of lesions as hypointense compared with the liver, because of the accumul ... Full text Link to item Cite

Endoleaks after endovascular abdominal aortic aneurysm repair: management strategies according to CT findings.

Journal Article AJR Am J Roentgenol · April 2009 Featured Publication OBJECTIVE: With increasing use of endovascular techniques for repair of abdominal aortic aneurysms, the prevalence of leakage into excluded aneurysm sacs (endoleaks) as a complication has risen. We will describe and illustrate the imaging findings for endo ... Full text Link to item Cite

Changes to resident call and the dilution of education.

Journal Article J Am Coll Radiol · April 2009 Featured Publication Full text Link to item Cite

Median nerve injury as a result of medial brachial fascial compartment syndrome.

Journal Article J Vasc Interv Radiol · November 2007 Featured Publication A case of brachial plexus injury after brachial arteriography is reported. Percutaneous catheterization of the brachial artery for angiography and intervention is performed when contraindications for the femoral approach exist. Access-related complications ... Full text Link to item Cite