Scholars@Duke
Quinn Ostrom

Quinn Ostrom

Assistant Professor in Neurosurgery
Neurosurgery, Neuro-Oncology
quinn.ostrom@duke.edu
571 Research Drive, MSRB-1, Rm 442, Durham, NC 27710

Selected Publications

Supplementary Table S4 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · November 26, 2025 <p>Supplementary Table S4. Multivariate MR estimates of direct causal effects of traits on lung cancer individually conditioned on genetically influenced smoking, alcohol use, socioeconomic status, and educational attainment.</p> Full text Cite

Supplemental Table 4 from Genetic Factors Associated with Absolute and Relative Plasma Concentrations of Calcitriol

Other · November 26, 2025 <p>Supplemental Table 4. Calcitriol-24,25-dihydroxyvitamin D3-calcifediol proportion ratio (C24CPR) and calcitriol (1,25(OH)2D3) adjusted least squares mean by demographic and environmental factors.</p> ... Full text Cite

Supplemental Table 2 from Genetic Factors Associated with Absolute and Relative Plasma Concentrations of Calcitriol

Other · November 26, 2025 <p>Supplemental Table 2. Allele Frequencies and Hardy-Weinberg Equilibrium (HWE) among African American (AA) and European American (EA) Participants (Central Pennsylvania) compared with 1000 Genomes African (AFR) and European (EUR) Population ... Full text Cite

Supplementary Table S5 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · November 26, 2025 <p>Supplementary Table S5. Multivariate MR estimates of direct causal effects of traits on lung cancer dually conditioned on genetically influenced smoking and educational attainment</p> ... Full text Cite

Supplementary Table S1 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · November 26, 2025 <p>Supplementary Table S1. Overview of Transdisciplinary Research of Cancer in Lung of the International Lung Cancer Consortium (TRICL-ILCCO) and the OncoArray Consortium GWAS studies</p> ... Full text Cite

Supplementary Table 1 from Genetic Factors Associated with Absolute and Relative Plasma Concentrations of Calcitriol

Other · November 26, 2025 <p>Supplemental Table 1. Distribution of Vitamin D Biomarkers By Race/Ethnicity, Sex and Oral Contraceptive Use.</p> ... Full text Cite

Supplemental Table 3 from Genetic Factors Associated with Absolute and Relative Plasma Concentrations of Calcitriol

Other · November 26, 2025 <p>Supplemental Table 3. Pairwise D’ and r2 Linkage Disequilibrium Values between Single Nucleotide Polymorphisms and Spearman's Correlation with West African Genetic Ancestry Proportion, African American (N=188) matched with European America ... Full text Cite

Supplementary Table S2 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · November 26, 2025 <p>Supplementary Table S2. Complete list of SNPs used as genetic instrumental variables (IVs) for causal effect modeling of traits with lung cancer outcomes.</p> ... Full text Cite

Supplementary Figure S2 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · November 26, 2025 <p>Supplementary Figure S2. IVW multivariate MR estimation of direct impact of traits on lung squamous cell carcinoma development, conditioned on smoking (pack years per lifespan), income, and education.</p> ... Full text Cite

Supplementary Figure S3 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · November 26, 2025 <p>Supplementary Figure S3. IVW multivariate MR estimation of direct impact of traits on small cell lung cancer development, conditioned on smoking (pack years per lifespan), income, and education.</p> ... Full text Cite

Supplementary Table S3 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · November 26, 2025 <p>Supplementary Table S3. Univariate MR estimations of total causal effects between traits with lung cancer risks.</p> ... Full text Cite

Supplementary Figure S1 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · November 26, 2025 <p>Supplementary Figure S1. IVW multivariate MR estimation of direct impact of traits on lung adenocarcinoma development, conditioned on smoking (pack years per lifespan), income, and years of schooling.</p> ... Full text Cite

Supplementary Figure 1 from Genetic Factors Associated with Absolute and Relative Plasma Concentrations of Calcitriol

Other · November 26, 2025 <p>Supplemental Figures 1a through 1d. Log linear plots of Plasma Calcitriol (1,25(OH)2D3) and plasma Calcitriol-24,25-Dihydroxyvitamin D3-Calcifediol Proportion ratio (C24CPR) in Relation to the Skin Melanin Index (SMI) and West African Gene ... Full text Cite

EPID-25. Molecular Epidemiology of Adult Diffuse Gliomas in the United States

Conference Neuro-Oncology · November 11, 2025 AbstractINTRODUCTIONUS cancer registries recently started collecting data on brain molecular markers, providing for the first t ... Full text Cite

RADT-33. PROGNOSTIC AND PREDICTIVE EFFECT OF AGE IN MOLECULARLY-DEFINED LOWER GRADE GLIOMAS: A REPORT FROM THE PROSPECTIVE GLIOMA RESEARCH (PROGRES) DATABASE

Conference Neuro-Oncology · November 11, 2025 AbstractPURPOSEAge over 40 years is commonly regarded as a “high risk” feature and potential indication for adjuvant chemoradio ... Full text Cite

EPID-07. Treatment with gabapentin associated with improved survival in elderly glioblastoma patients

Conference Neuro-Oncology · November 11, 2025 AbstractGlioblastoma’hijacks’ neuronal pathways to drive tumor growth, and drugs affecting the function of these pathways may potentiate survival gains. Prior studies suggest a clinical benefit with using ... Full text Cite

EPID-05. Incidence of glioma varies significantly by global region

Conference Neuro-Oncology · November 11, 2025 AbstractBrain and other central nervous system (CNS) tumors are a significant source of global morbidity and mortality. Despite decades of epidemiological research, there are few known risk factors for th ... Full text Cite

IMMU-08. Metabolic reprogramming of CD8+ T-Cells by DPP-4 inhibition for glioblastoma immunotherapy

Conference Neuro-Oncology · November 11, 2025 AbstractGlioblastoma (GBM) is characterized by T cell exclusion and exhaustion. Therefore, there is a pressing need to identify molecular targets for improved T cell response in GBM. We recently showed th ... Full text Cite

EPID-06. The Key LARGO study: Building an international resource for glioblastoma epidemiology

Conference Neuro-Oncology · November 11, 2025 AbstractDespite decades of epidemiological research, no glioblastoma risk factors have been identified that explain substantial risk. Prior studies often rely on single- or multi-center recruitment, which ... Full text Cite

IMMU-81. Glioblastoma and other intracranial pathologies elicit systemic sympathetic hyperactivity that limits immunotherapeutic responses

Conference Neuro-Oncology · November 11, 2025 AbstractImmunotherapies remain largely ineffective against intracranial malignancies such as glioblastoma (GBM), in part due to profound systemic and local immune dysfunction. Hallmarks of systemic immune ... Full text Cite

INNV-37. Real-world observation rates and treatment patterns in IDH-mutated glioma: implications for targeted therapy use

Conference Neuro-Oncology · November 11, 2025 AbstractINTRODUCTIONThe approval of vorasidenib marks a paradigm shift in the management of IDH-mutated (mIDH) gliomas. This st ... Full text Cite

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2018-2022.

Journal Article Neuro Oncol · October 14, 2025 The Central Brain Tumor Registry of the United States (CBTRUS), an aggregation of data from the Centers for Disease Control and Prevention's National Program of Cancer Registries and the National Cancer Institute's Surveillance, Epidemiology and End Result ... Full text Link to item Cite

CBTRUS Statistical Facts

Journal Article Neuro-Oncology · October 14, 2025 Full text Cite

P14.21.B IMPACTS OF SEX AND RACE/ETHNICITY ON INCIDENCE OF VESTIBULAR SCHWANNOMA ACROSS THE LIFESPAN IN THE UNITED STATES

Conference Neuro-Oncology · October 3, 2025 AbstractBACKGROUNDVestibular schwannomas (VS) are benign tumors arising in the vestibulocochlear nerve. Previous research has identifi ... Full text Cite

The effect of sex on vestibular schwannoma incidence varies across the lifespan and modifies associations with race/ethnicity.

Journal Article Res Sq · September 29, 2025 PURPOSE: Vestibular schwannoma (VS) is a benign tumor of the eighth cranial nerve with incidence that differs by age, sex, and race/ethnicity. Prior research has not characterized how the contributions of sex and race/ethnicity to VS risk may interact or v ... Full text Link to item Cite

CBTRUS Statistical Report: Pediatric Brain Tumor Foundation Childhood and Adolescent Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2017-2021.

Journal Article Neuro Oncol · September 15, 2025 This report comprehensively describes the most up-to-date incidence of primary brain and other central nervous system (CNS) tumors in children and adolescents (ages 0-19 years old), utilizing population-based data collected and reported by central cancer r ... Full text Link to item Cite

Determinants of geographic variation in the incidence of adult nonmalignant meningioma in the United States, 2010-2019.

Journal Article Cancer · September 15, 2025 BACKGROUND: US incidence rates of nonmalignant brain tumors are 3-fold higher in highest versus lowest incidence states. A county-level analysis was conducted to assess whether geographic variation in nonmalignant meningioma (NMM) incidence is related to d ... Full text Link to item Cite

PBTF Childhood and Adolescent Brain Tumor Facts.

Journal Article Neuro Oncol · September 15, 2025 Full text Link to item Cite

Atopy Improves Survival and Decreases Risk of Brain Metastasis in Cutaneous Melanoma.

Journal Article Cancer Epidemiol Biomarkers Prev · September 2, 2025 BACKGROUND: Development of new melanoma therapies has increased survival, and more patients are living to develop brain metastasis (BrM). Identifying those at increased risk of BrM is of significant public health importance, and our objective was to assess ... Full text Link to item Cite

Table S6 from Atopy Improves Survival and Decreases Risk of Brain Metastasis in Cutaneous Melanoma

Other · September 2, 2025 <p>Table S6 provides results by timing of brain metastasis (at diagnosis or after diagnosis)</p> ... Full text Cite

Table S2 from Atopy Improves Survival and Decreases Risk of Brain Metastasis in Cutaneous Melanoma

Other · September 2, 2025 <p>Table S2 shows codes used to classify therapies</p> ... Full text Cite

Figure S4 from Atopy Improves Survival and Decreases Risk of Brain Metastasis in Cutaneous Melanoma

Other · September 2, 2025 <p>Figure S4 shows sex-specific hazard of death based on atopic trait</p> ... Full text Cite

Table S3 from Atopy Improves Survival and Decreases Risk of Brain Metastasis in Cutaneous Melanoma

Other · September 2, 2025 <p>Table S3 provides an overview of characteristics of included individuals by atopic disease status</p> ... Full text Cite

Figure S2 from Atopy Improves Survival and Decreases Risk of Brain Metastasis in Cutaneous Melanoma

Other · September 2, 2025 <p>Figure S2 shows the correlation between atopic conditions and other prognostic variables</p> ... Full text Cite

Figure S5 from Atopy Improves Survival and Decreases Risk of Brain Metastasis in Cutaneous Melanoma

Other · September 2, 2025 <p>Figure S5 shows probability of brain metastasis free survival by atopic trait</p> ... Full text Cite

Table S7 from Atopy Improves Survival and Decreases Risk of Brain Metastasis in Cutaneous Melanoma

Other · September 2, 2025 <p>Table S7 provides results for those without metastatic disease at diagnosis</p> ... Full text Cite

Table S5 from Atopy Improves Survival and Decreases Risk of Brain Metastasis in Cutaneous Melanoma

Other · September 2, 2025 <p>Table S5 provides adjusted results from survival and cumulative incidence analyses</p> ... Full text Cite

Data from Atopy Improves Survival and Decreases Risk of Brain Metastasis in Cutaneous Melanoma

Other · September 2, 2025 <div>AbstractBackground:<p>Development of new melanoma therapies has increased survival, and more patients are living to develop brain metastasis (BrM). Identifying those at increased risk of BrM is of significant public health importan ... Full text Cite

Table S1 from Atopy Improves Survival and Decreases Risk of Brain Metastasis in Cutaneous Melanoma

Other · September 2, 2025 <p>Table S1 shows codes used to classify atopic disease types</p> ... Full text Cite

Figure S3 from Atopy Improves Survival and Decreases Risk of Brain Metastasis in Cutaneous Melanoma

Other · September 2, 2025 <p>Figure S3 shows association between atopic traits and treatment choice</p> ... Full text Cite

Table S4 from Atopy Improves Survival and Decreases Risk of Brain Metastasis in Cutaneous Melanoma

Other · September 2, 2025 <p>Table S4 provides results from univariate survival and cumulative incidence analyses</p> ... Full text Cite

Figure S1 from Atopy Improves Survival and Decreases Risk of Brain Metastasis in Cutaneous Melanoma

Other · September 2, 2025 <p>Figure S1 illustrates the data filtering process used to build the analytic dataset</p> ... Full text Cite

A review of diffuse hemispheric glioma, H3 G34-mutant disease development, DNA repair, microenvironment, and treatments on the horizon.

Journal Article NPJ Precis Oncol · August 14, 2025 Diffuse hemispheric glioma H3 G34-mutant is primarily diagnosed in adolescents/young adults. While molecular diagnostics have improved, cellular mechanisms that drive tumor progression and therapy resistance are poorly understood. Combining previous publis ... Full text Link to item Cite

Glioblastoma in Adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) Consensus Review on Current Management and Future Directions.

Journal Article Neuro Oncol · August 13, 2025 Glioblastoma is the most common type of malignant primary brain tumor and a major cause of morbidity and mortality. In 2021 the World Health Organization updated the classification of Central Nervous System (CNS) tumors to restrict glioblastomas to isocitr ... Full text Link to item Cite

Characteristics of long-term glioblastoma survivors diagnosed from 2010 to 2016 in the United States.

Journal Article Cancer Epidemiol · August 2025 BACKGROUND: Glioblastoma (GBM) is the most common malignant primary central nervous system (CNS) tumor, accounting for half (50.9 %) of all malignant tumors diagnosed in the US. We conducted a population-based analysis using Centers for Disease Control and ... Full text Link to item Cite

Years of life lost due to central nervous system tumor subtypes in the United States.

Journal Article Neuro Oncol · June 15, 2025 BACKGROUND: Years of Life Lost (YLL) is a disease burden measure quantifying the number of years lost due to premature mortality for a given disease. The present study sought to assess YLL for primary brain and other central nervous system (CNS) tumor hist ... Full text Link to item Cite

Grade-stratified meningioma risk among individuals who are non-Hispanic Black and interactions with male sex.

Journal Article J Natl Cancer Inst · February 1, 2025 BACKGROUND: Meningioma risk factors include older age, female sex, and being Black/African American. Limited data explore how meningioma risk in individuals who are Black varies across the lifespan, interacts with sex, and differs by tumor grade. METHODS: ... Full text Link to item Cite

Central nervous system tumors in adolescents and young adults: A Society for Neuro-Oncology Consensus Review on diagnosis, management, and future directions.

Journal Article Neuro Oncol · January 12, 2025 Adolescents and young adults (AYAs; ages 15-39 years) are a vulnerable population facing challenges in oncological care, including access to specialized care, transition of care, unique tumor biology, and poor representation in clinical trials. Brain tumor ... Full text Link to item Cite

Survivorship from pediatric and adult brain tumors: The 2024 Brain Tumor Epidemiology Consortium meeting report.

Journal Article Neurooncol Adv · 2025 The Brain Tumor Epidemiology Consortium (BTEC) is an international organization with membership of individuals from the scientific community with interests related to brain tumor epidemiology, including surveillance, classification, methodology, etiology, ... Full text Link to item Cite

The intersection of race, ethnicity, and urbanicity on treatment paradigms and clinical outcomes for non-malignant primary tumors of the spine.

Journal Article Cancer Epidemiol · December 2024 BACKGROUND: Non-malignant primary tumors of the spine (NMPTS) patients in rural areas face unique barriers that may limit their capacity to receive optimal care. With a lower geographical distribution of neurosurgical specialists and limited healthcare inf ... Full text Link to item Cite

EPID-16. GENOMIC ANCESTRY-RELATED RISK RATIOS FOR GLIOBLASTOMA INCIDENCE AMONG GLOBAL POPULATIONS AND RACIAL/ETHNIC GROUPS WITHIN THE UNITED STATES

Conference Neuro-Oncology · November 11, 2024 AbstractGlioblastoma (GBM) incidence varies globally, elevated rates in Europe and lower rates in Asia, Latin America, and Africa. While partially attributable to national differences in cancer diagnosis and ... Full text Cite

EPID-05. THE INCREASED RISK OF MENINGIOMA AMONG INDIVIDUALS WHO ARE NON-HISPANIC BLACK IS MAGNIFIED AMONG MALES AND AMONG THOSE DIAGNOSED WITH GRADE 2-3 TUMORS

Conference Neuro-Oncology · November 11, 2024 AbstractBACKGROUNDDemographic factors associated with elevated meningioma incidence include older age, female sex, and Black race. The ... Full text Cite

EPID-23. HISTORY OF TYPE III IMMUNE HYPERSENSITIVITY IMPROVES SURVIVAL IN GLIOBLASTOMA

Conference Neuro-Oncology · November 11, 2024 AbstractPreexisting atopy, particularly allergic rhinitis, is consistently associated with decreased risk of glioma, and there is evidence that preexisting autoimmune conditions may also decrease risk. Gliob ... Full text Cite

IMMU-09. REVERSING SYSTEMIC T CELL DYSFUNCTION TO LICENSE IMMUNOTHERAPY IN INTRACRANIAL TUMORS

Conference Neuro-Oncology · November 11, 2024 AbstractIntracranial tumors present unique challenges for immunotherapy. These can include both local and systemic modes of immune suppression, the mechanistic underpinnings of which are incompletely underst ... Full text Cite

EPCO-58. INTEGRATIVE PROTEOGENOMIC ANALYSES REVEAL INSIGHTS INTO SUBTYPE-SPECIFIC GLIOMA RISK

Conference Neuro-Oncology · November 11, 2024 AbstractGliomas are heterogeneous brain tumors with prognostically-significant subtypes and few risk factors. IDH-wildtype glioblastoma, the most common subtype, carries a dismal prognosis. Using the largest ... Full text Cite

DISP-08. GBM PATIENTS FACE TTF ACCESS AND INFORMATION INEQUITY THAT MAY IMPACT PATIENT OUTCOMES AND QUALITY-OF-LIFE

Conference Neuro-Oncology · November 11, 2024 AbstractWe evaluated the quality and accessibility of healthcare for Glioblastoma (GBM) patients across the United States through an online survey distributed to the OurBrainBank community and partners and p ... Full text Cite

P25.01.B ASSOCIATION BETWEEN EXPOSURE TO AIR POLLUTION AND BRAIN TUMOR INCIDENCE IN THE UNITED STATES

Conference Neuro-Oncology · October 17, 2024 AbstractBACKGROUNDAir pollution contains known human carcinogens. Prior studies evaluating an association between pollution exposure a ... Full text Cite

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2017-2021.

Journal Article Neuro Oncol · October 6, 2024 The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with the Centers for Disease Control and Prevention and the National Cancer Institute, is the largest population-based registry focused exclusively on primary brain and other ... Full text Link to item Cite

Meningioma: International Consortium on Meningiomas consensus review on scientific advances and treatment paradigms for clinicians, researchers, and patients.

Journal Article Neuro Oncol · October 3, 2024 Meningiomas are the most common primary intracranial tumors in adults and are increasing in incidence due to the aging population and increased access to neuroimaging. While most exhibit nonmalignant behavior, a subset of meningiomas are biologically aggre ... Full text Link to item Cite

Genome-wide polygenic risk scores predict risk of glioma and molecular subtypes.

Journal Article Neuro Oncol · October 3, 2024 BACKGROUND: Polygenic risk scores (PRS) aggregate the contribution of many risk variants to provide a personalized genetic susceptibility profile. Since sample sizes of glioma genome-wide association studies (GWAS) remain modest, there is a need to efficie ... Full text Link to item Cite

Genetic variation near GRB10 associated with bone growth and osteosarcoma risk in canine and human populations.

Journal Article Cancer Epidemiol · October 2024 BACKGROUND: Canine and human osteosarcoma are similar in clinical presentation and tumor genomics. Giant breed dogs experience elevated osteosarcoma incidence, and taller stature remains a consistent risk factor for human osteosarcoma. Whether evolutionari ... Full text Link to item Cite

Supplementary Figure S1 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · September 16, 2024 <p>Supplementary Figure S1. IVW multivariate MR estimation of direct impact of traits on lung adenocarcinoma development, conditioned on smoking (pack years per lifespan), income, and years of schooling.</p> ... Full text Cite

Supplementary Figure S2 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · September 16, 2024 <p>Supplementary Figure S2. IVW multivariate MR estimation of direct impact of traits on lung squamous cell carcinoma development, conditioned on smoking (pack years per lifespan), income, and education.</p> ... Full text Cite

Data from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · September 16, 2024 <div>Abstract<p>Introduction: Lung cancer is a complex polygenic disorder. Analysis with Mendelian randomization (MR) allows for genetically predicted risks to be estimated between exposures and outcomes. Methods: We analyzed 345 heri ... Full text Cite

Supplementary Figure S1 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · September 16, 2024 <p>Supplementary Figure S1. IVW multivariate MR estimation of direct impact of traits on lung adenocarcinoma development, conditioned on smoking (pack years per lifespan), income, and years of schooling.</p> ... Full text Cite

Supplementary Table S4 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · September 16, 2024 <p>Supplementary Table S4. Multivariate MR estimates of direct causal effects of traits on lung cancer individually conditioned on genetically influenced smoking, alcohol use, socioeconomic status, and educational attainment.</p> Full text Cite

Supplementary Figure S3 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · September 16, 2024 <p>Supplementary Figure S3. IVW multivariate MR estimation of direct impact of traits on small cell lung cancer development, conditioned on smoking (pack years per lifespan), income, and education.</p> ... Full text Cite

Supplementary Table S5 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · September 16, 2024 <p>Supplementary Table S5. Multivariate MR estimates of direct causal effects of traits on lung cancer dually conditioned on genetically influenced smoking and educational attainment</p> ... Full text Cite

Supplementary Figure S2 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · September 16, 2024 <p>Supplementary Figure S2. IVW multivariate MR estimation of direct impact of traits on lung squamous cell carcinoma development, conditioned on smoking (pack years per lifespan), income, and education.</p> ... Full text Cite

Supplementary Table S1 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · September 16, 2024 <p>Supplementary Table S1. Overview of Transdisciplinary Research of Cancer in Lung of the International Lung Cancer Consortium (TRICL-ILCCO) and the OncoArray Consortium GWAS studies</p> ... Full text Cite

Supplementary Table S3 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · September 16, 2024 <p>Supplementary Table S3. Univariate MR estimations of total causal effects between traits with lung cancer risks.</p> ... Full text Cite

Supplementary Table S2 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · September 16, 2024 <p>Supplementary Table S2. Complete list of SNPs used as genetic instrumental variables (IVs) for causal effect modeling of traits with lung cancer outcomes.</p> ... Full text Cite

Supplementary Table S5 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · September 16, 2024 <p>Supplementary Table S5. Multivariate MR estimates of direct causal effects of traits on lung cancer dually conditioned on genetically influenced smoking and educational attainment</p> ... Full text Cite

Supplementary Table S1 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · September 16, 2024 <p>Supplementary Table S1. Overview of Transdisciplinary Research of Cancer in Lung of the International Lung Cancer Consortium (TRICL-ILCCO) and the OncoArray Consortium GWAS studies</p> ... Full text Cite

Supplementary Table S3 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · September 16, 2024 <p>Supplementary Table S3. Univariate MR estimations of total causal effects between traits with lung cancer risks.</p> ... Full text Cite

Supplementary Figure S3 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · September 16, 2024 <p>Supplementary Figure S3. IVW multivariate MR estimation of direct impact of traits on small cell lung cancer development, conditioned on smoking (pack years per lifespan), income, and education.</p> ... Full text Cite

Supplementary Table S2 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · September 16, 2024 <p>Supplementary Table S2. Complete list of SNPs used as genetic instrumental variables (IVs) for causal effect modeling of traits with lung cancer outcomes.</p> ... Full text Cite

Supplementary Table S4 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Other · September 16, 2024 <p>Supplementary Table S4. Multivariate MR estimates of direct causal effects of traits on lung cancer individually conditioned on genetically influenced smoking, alcohol use, socioeconomic status, and educational attainment.</p> Full text Cite

EPID-01. ESTIMATING THE BURDEN DUE TO BRAIN AND OTHER CNS TUMORS IN ADOLESCENTS IN THE UNITED STATES

Conference Neuro-Oncology · June 18, 2024 AbstractBACKGROUNDBrain and other central nervous system (CNS) tumors in adolescents have unique biological and behavioral distinction ... Full text Cite

CBTRUS Statistical Report: American Brain Tumor Association & NCI Neuro-Oncology Branch Adolescent and Young Adult Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2016-2020.

Journal Article Neuro Oncol · May 6, 2024 Recent analyses have shown that, whereas cancer survival overall has been improving, it has not improved for adolescents and young adults ages 15-39 years (AYA). The clinical care of AYA with primary brain and other central nervous system (CNS) tumors (BT) ... Full text Link to item Cite

Sex differences in adverse events in Medicare individuals ≥ 66 years of age post glioblastoma treatment.

Journal Article J Neurooncol · May 2024 PURPOSE: Glioblastoma (GB) is the most common primary malignant brain tumor with the highest incidence occurring in older adults with a median age at diagnosis of 64 years old. While treatment often improves survival it brings toxicities and adverse events ... Full text Link to item Cite

Association of county-level socioeconomic status with meningioma incidence and outcomes.

Journal Article Neuro Oncol · April 5, 2024 BACKGROUND: Prior literature suggests that individual socioeconomic status (SES) may influence incidence, treatments, and survival of brain tumor cases. We aim to conduct the first national study to evaluate the association between US county-level SES and ... Full text Link to item Cite

The impact of COVID-19 on 2020 monthly incidence trends of primary brain and other CNS tumors.

Journal Article Neuro Oncol · April 5, 2024 BACKGROUND: To mitigate disease spread, restrictions implemented in the United States surrounding the COVID-19 pandemic created an environment that led to delays in cancer diagnosis. The data needed to accurately analyze the impact of the pandemic on brain ... Full text Link to item Cite

Abstract PR-001: Beta-adrenergic blockade licenses the use of immunotherapy in primary brain tumors and brain metastases

Conference Cancer Research · March 4, 2024 AbstractImmunotherapy is less effective against intracranial metastases compared to extracranial metastases and ineffective against primary brain tumors such as glioblastoma. Brain tumors present a unique ch ... Full text Cite

Association between county-level socioeconomic status and the incidence of and surgical treatment for pituitary adenoma.

Journal Article J Neurosurg · March 1, 2024 OBJECTIVE: The objective of this study was to evaluate the association between county-level socioeconomic status (SES) and the incidence of and surgical treatment for pituitary adenoma (PA). METHODS: Using the Centers for Disease Control and Prevention's N ... Full text Link to item Cite

Brain tumors in United States military veterans.

Journal Article Neuro Oncol · February 2, 2024 BACKGROUND: Comprehensive analysis of brain tumor incidence and survival in the Veteran population has been lacking. METHODS: Veteran data were obtained from the Veterans Health Administration (VHA) Medical Centers via VHA Corporate Data Warehouse. Brain t ... Full text Link to item Cite

Childhood, adolescent, and adult primary brain and central nervous system tumor statistics for practicing healthcare providers in neuro-oncology, CBTRUS 2015-2019.

Journal Article Neurooncol Pract · February 2024 BACKGROUND: The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with the Centers for Disease Control and Prevention (CDC) and National Cancer Institute (NCI), is the largest aggregation of histopathology-specific population-bas ... Full text Link to item Cite

Genetic association between atopic disease and osteoarthritis.

Journal Article Osteoarthritis Cartilage · February 2024 OBJECTIVES: To evaluate the association between genetically determined risk for atopic disease and osteoarthritis (OA). METHODS: We performed linkage disequilibrium (LD) score regression using 1000 Genomes Project European samples as a reference for patter ... Full text Link to item Cite

Association Between Urbanicity and Outcomes Among Patients with Spinal Cord Ependymomas in the United States.

Journal Article World Neurosurg · January 2024 BACKGROUND: Spinal cord ependymomas (SCEs) represent the most common intramedullary spinal cord tumors among adults. Research shows that access to neurosurgical care and patient outcomes can be greatly influenced by patient location. This study investigate ... Full text Link to item Cite

Impact of environment on pediatric and adult brain tumors: The 2023 Brain Tumor Epidemiology Consortium meeting report.

Journal Article Clin Neuropathol · 2024 The Brain Tumor Epidemiology Consortium (BTEC) is an international organization with membership of individuals from the scientific community with interests related to brain tumor epidemiology including surveillance, classification, methodology, etiology, a ... Full text Link to item Cite

Capturing evolving definitions of 12 select rare CNS tumors: a timely report from CBTRUS and NCI-CONNECT.

Journal Article J Neurooncol · November 2023 PURPOSE: Incidence, prevalence, and survival are population-based statistics describing cancer burden. The National Cancer Institute's (NCI) Comprehensive Oncology Network Evaluating Rare CNS Tumors (NCI-CONNECT) specializes in tumor biology and outcomes f ... Full text Link to item Cite

Design and quality control of large-scale two-sample Mendelian randomization studies

Journal Article International Journal of Epidemiology · October 5, 2023 AbstractBackgroundMendelian randomization (MR) studies are susceptible to metadata errors (e.g. incorrect specification of the effect ... Full text Cite

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2016-2020.

Journal Article Neuro Oncol · October 4, 2023 The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with the Centers for Disease Control and Prevention and the National Cancer Institute, is the largest population-based registry focused exclusively on primary brain and other ... Full text Link to item Cite

Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study.

Journal Article Cancer Epidemiol Biomarkers Prev · October 2, 2023 INTRODUCTION: Lung cancer is a complex polygenic disorder. Analysis with Mendelian randomization (MR) allows for genetically predicted risks to be estimated between exposures and outcomes. METHODS: We analyzed 345 heritable traits from the United Kingdom B ... Full text Link to item Cite

Associations between urbanicity and spinal cord astrocytoma management and outcomes.

Journal Article Cancer Epidemiol · October 2023 BACKGROUND: The management of spinal cord astrocytomas (SCAs) remains controversial and may include any combination of surgery, radiation, and chemotherapy. Factors such as urbanicity (metropolitan versus non-metropolitan residence) are shown to be associa ... Full text Open Access Link to item Cite

P21.05.B CAPTURING EVOLVING DEFINITIONS OF 12 SELECT RARE CNS TUMORS: A TIMELY REPORT FROM CBTRUS AND NCI-CONNECT

Conference Neuro-Oncology · September 8, 2023 AbstractBACKGROUNDHistopathology-specific incidence, prevalence, and survival are essential population-based cancer statistics that de ... Full text Cite

P21.04.A IMPROVEMENTS IN SURVIVAL FOR GLIOBLASTOMA IN THE POST-STUPP PROTOCOL ERA

Conference Neuro-Oncology · September 8, 2023 AbstractBACKGROUNDThe Stupp protocol was accepted as standard of care for glioblastoma in 2005, and has led to significant increases i ... Full text Cite

Complete prevalence of primary malignant and nonmalignant brain tumors in comparison to other cancers in the United States.

Journal Article Cancer · August 15, 2023 BACKGROUND: Primary brain tumors (BTs) are rare, but cause morbidity and mortality disproportionately to their incidence. Prevalence estimates population-level cancer burdens at a specified time. This study estimates the prevalence of malignant and non-mal ... Full text Link to item Cite

The association of Medicaid expansion and pediatric cancer overall survival.

Journal Article J Natl Cancer Inst · June 8, 2023 Medicaid eligibility expansion, though not directly applicable to children, has been associated with improved access to care in children with cancer, but associations with overall survival are unknown. Data for children ages 0 to 14 years diagnosed with ca ... Full text Link to item Cite

Combination beta-adrenergic blockade and immunotherapy for the treatment of primary and metastatic brain cancer.

Conference Journal of Clinical Oncology · June 1, 2023 e14017 Background: Brain tumors present a unique challenge to immunotherapeutic success, as immune responses in patients with brain tumors are suppressed both within the tumor microenvironment and peripherally. The systemic immun ... Full text Cite

Genetic Factors Associated with Absolute and Relative Plasma Concentrations of Calcitriol.

Journal Article Cancer Epidemiol Biomarkers Prev · May 1, 2023 BACKGROUND: Little is known regarding factors associated with calcitriol and a relative measure of calcitriol, the calcitriol-24,25-dihydroxyvitamin D3-calcifediol proportion ratio (C24CPR). METHODS: Using a cross-sectional study design, healthy young adul ... Full text Link to item Cite

The association between genetically elevated polyunsaturated fatty acids and risk of cancer.

Journal Article EBioMedicine · May 2023 BACKGROUND: The causal relevance of polyunsaturated fatty acids (PUFAs) for risk of site-specific cancers remains uncertain. METHODS: Using a Mendelian randomization (MR) framework, we assessed the causal relevance of PUFAs for risk of cancer in European a ... Full text Link to item Cite

The joint impacts of sex and race/ethnicity on incidence of grade 1 versus grades 2-3 meningioma across the lifespan.

Journal Article Neurooncol Adv · May 2023 BACKGROUND: Previous research has identified older age, African-American race, and female sex as meningioma risk factors, but there is limited information on their joint effects, or on how these demographic factors vary across strata of tumor grade. METHOD ... Full text Open Access Link to item Cite

The genomic landscape of familial glioma.

Journal Article Sci Adv · April 28, 2023 Glioma is a rare brain tumor with a poor prognosis. Familial glioma is a subset of glioma with a strong genetic predisposition that accounts for approximately 5% of glioma cases. We performed whole-genome sequencing on an exploratory cohort of 203 individu ... Full text Link to item Cite

National-level overall survival patterns for molecularly-defined diffuse glioma types in the United States.

Journal Article Neuro Oncol · April 6, 2023 BACKGROUND: Molecularly-defined diffuse glioma types-including IDH-wildtype glioblastoma, IDH-mutant astrocytoma, IDH-mutant 1p/19q-codeleted oligodendroglioma, and H3 K27M-mutant diffuse midline glioma-were incorporated into U.S. cancer registry reporting ... Full text Link to item Cite

Data from Transcriptome-Wide Association Study Identifies New Candidate Susceptibility Genes for Glioma

Other · March 31, 2023 <div>Abstract<p>Genome-wide association studies (GWAS) have so far identified 25 loci associated with glioma risk, with most showing specificity for either glioblastoma (GBM) or non-GBM tumors. The majority of these GWAS susceptibility ... Full text Cite

Mortality trends in primary malignant brain and central nervous system tumors vary by histopathology, age, race, and sex.

Conference J Neurooncol · March 2023 PURPOSE: Primary malignant brain and other central nervous system tumors are rare cancers that have shown rising mortality rates in recent years. To elucidate potential factors involved in this rising death rate, we examined mortality trends for primary ma ... Full text Link to item Cite

Exposure to radon and heavy particulate pollution and incidence of brain tumors.

Journal Article Neuro Oncol · February 14, 2023 BACKGROUND: Global incidence for brain tumors varies substantially without explanation. Studies correlating radon exposure and incidence are inconclusive. Particulate pollution has been linked to increased tumor incidence. Particulates may disrupt the bloo ... Full text Link to item Cite

Influence of county-level geographic/ancestral origin on glioma incidence and outcomes in US Hispanics.

Journal Article Neuro Oncol · February 14, 2023 BACKGROUND: Glioma incidence is 25% lower in Hispanics than White non-Hispanics. The US Hispanic population is diverse, and registry-based analyses may mask incidence differences associated with geographic/ancestral origins. METHODS: County-level glioma in ... Full text Link to item Cite

Incidence and survival of choroid plexus tumors in the United States.

Journal Article Neurooncol Pract · February 2023 BACKGROUND: There are limited data available on incidence and survival of patients with choroid plexus tumors (CPT). This study provides the most current epidemiological analysis of choroid plexus tumors from 2004 to 2017 in the United States. METHODS: Dat ... Full text Link to item Cite

Molecular marker testing and reporting completeness for adult-type diffuse gliomas in the United States.

Journal Article Neurooncol Pract · February 2023 BACKGROUND: A newly developed brain molecular marker (BMM) data item was implemented by US cancer registries for individuals diagnosed with brain tumors in 2018-including IDH and 1p/19q-co-deletion statuses for adult-type diffuse gliomas. We thus investiga ... Full text Link to item Cite

Common Germline Risk Variants Impact Somatic Alterations and Clinical Features across Cancers.

Journal Article Cancer Res · January 4, 2023 UNLABELLED: Aggregation of genome-wide common risk variants, such as polygenic risk score (PRS), can measure genetic susceptibility to cancer. A better understanding of how common germline variants associate with somatic alterations and clinical features c ... Full text Link to item Cite

Pediatric brain tumors: Origins, epidemiology, and classification - The 2022 Brain Tumor Epidemiology Consortium meeting report.

Journal Article Clin Neuropathol · 2023 The Brain Tumor Epidemiology Consortium (BTEC) is an international organization that fosters collaboration among scientists focused on understanding the epidemiology of brain tumors with interests ranging from the etiology of brain tumor development and ou ... Full text Link to item Cite

BRAIN TUMORS IN UNITED STATES MILITARY VETERANS

Conference NEURO-ONCOLOGY · 2023 Cite

Molecular biomarker-defined brain tumors: Epidemiology, validity, and completeness in the United States.

Journal Article Neuro Oncol · November 2, 2022 BACKGROUND: Selected molecular biomarkers were incorporated into the US cancer registry reporting for patients with brain tumors beginning in 2018. We investigated the completeness and validity of these variables and described the epidemiology of molecular ... Full text Link to item Cite

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2015-2019.

Journal Article Neuro Oncol · October 5, 2022 The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with the Centers for Disease Control and Prevention and the National Cancer Institute, is the largest population-based registry focused exclusively on primary brain and other ... Full text Link to item Cite

Changes in survival over time for primary brain and other CNS tumors in the United States, 2004-2017.

Journal Article J Neurooncol · October 2022 PURPOSE: Despite advances in cancer diagnosis and clinical care, survival for many primary brain and other central nervous system (CNS) tumors remain poor. This study performs a comprehensive survival analysis on these tumors. METHODS: Survival differences ... Full text Link to item Cite

CBTRUS Statistical Report: Pediatric Brain Tumor Foundation Childhood and Adolescent Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2014-2018.

Journal Article Neuro Oncol · September 6, 2022 The CBTRUS Statistical Report: Pediatric Brain Tumor Foundation Childhood and Adolescent Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2014-2018 comprehensively describes the current population-based incidence of p ... Full text Link to item Cite

A population study of clinical trial accrual for women and minorities in neuro-oncology following the NIH Revitalization Act.

Journal Article Neuro Oncol · August 1, 2022 BACKGROUND: The NIH Revitalization Act, implemented 29 years ago, set to improve the representation of women and minorities in clinical trials. In this study, we investigate progress made in all phase therapeutic clinical trials for neuroepithelial CNS tum ... Full text Link to item Cite

Epidemiology of primary malignant non-osseous spinal tumors in the United States.

Journal Article Spine J · August 2022 BACKGROUND CONTEXT: Primary malignant non-osseous spinal tumors are relatively rare and this has led to a paucity of studies specifically examining the epidemiology of malignant spinal tumors. PURPOSE: To provide an updated and more comprehensive study exa ... Full text Link to item Cite

Epidemiologic evaluation of clinical outcomes in ethnic minorities with myelodysplastic syndromes.

Journal Article Leuk Res · August 2022 Since race/ethnicity and socioeconomic status (SES), including economic and educational disadvantage (EED), may impact overall survival (OS) in primary myelodysplastic syndromes (MDS), we analyzed the impact of these characteristics on OS in Non-Hispanic W ... Full text Link to item Cite

Aligning the Central Brain Tumor Registry of the United States (CBTRUS) histology groupings with current definitions.

Journal Article Neurooncol Pract · August 2022 BACKGROUND: The Central Brain Tumor Registry of the United States (CBTRUS) uses a histology grouping model based on the World Health Organization (WHO) classifications to group records for clinically relevant statistical reporting. Newly identified genetic ... Full text Link to item Cite

Primary brain and other central nervous system tumors in the United States (2014-2018): A summary of the CBTRUS statistical report for clinicians.

Journal Article Neurooncol Pract · May 2022 BACKGROUND: The Central Brain Tumor Registry of the United States (CBTRUS) contains information on all primary brain and other central nervous system (CNS) tumors diagnosed in the United States (US). Here we summarize the 2021 CBTRUS annual statistical rep ... Full text Link to item Cite

Epidemiology of pineoblastoma in the United States, 2000-2017.

Journal Article Neurooncol Pract · April 2022 BACKGROUND: Pineoblastoma (PB) is a rare malignant brain tumor originating in the pineal gland. Here, we provide a comprehensive epidemiological analysis of PB in the United States from 2000 to 2017. METHODS: Data on 1133 patients with PB were acquired fro ... Full text Link to item Cite

Importance of the intersection of age and sex to understand variation in incidence and survival for primary malignant gliomas.

Journal Article Neuro Oncol · February 1, 2022 BACKGROUND: Gliomas are the most common type of malignant brain and other CNS tumors, accounting for 80.8% of malignant primary brain and CNS tumors. They cause significant morbidity and mortality. This study investigates the intersection between age and s ... Full text Link to item Cite

The Epidemiology of Central Nervous System Tumors.

Chapter · February 2022 This article reviews the current epidemiology of central nervous system tumors. Population-level basic epidemiology, nationally and internationally, and current understanding of germline genetic risk are discussed, with a focus on known and well-studied ri ... Full text Link to item Cite

The Central Brain Tumor Registry of the United States Histopathological Grouping Scheme Provides Clinically Relevant Brain and Other Central Nervous System Categories for Cancer Registry Data.

Journal Article J Registry Manag · 2022 BACKGROUND: Brain and other central nervous system (CNS) tumors are a heterogenous collection of tumors, but they are generally reported in local and national cancer statistics as a single, large category. Although the collection of non-malignant brain and ... Link to item Cite

Epidemiology of Brain and Other CNS Tumors.

Chapter · November 24, 2021 PURPOSE OF REVIEW: Brain and other central nervous system (CNS) tumors, while rare, cause significant morbidity and mortality across all ages. This article summarizes the current state of the knowledge on the epidemiology of brain and other CNS tumors. REC ... Full text Link to item Cite

EPID-26. ALIGNING THE CBTRUS HISTOLOGY GROUPS WITH 2016 WHO CLASSIFICATION OF TUMORS OF THE CENTRAL NERVOUS SYSTEM

Conference Neuro-Oncology · November 12, 2021 AbstractBACKGROUNDThe Central Brain Tumor Registry of the United States (CBTRUS) uses a histology grouping scheme modeled after the Wo ... Full text Cite

EPID-11. A POPULATION STUDY OF CLINICAL TRIAL ACCRUAL FOR WOMEN AND MINORITIES IN NEURO-ONCOLOGY FOLLOWING THE NIH REVITALIZATION ACT

Conference Neuro-Oncology · November 12, 2021 AbstractINTRODUCTIONThe NIH Revitalization Act, implemented 29 years ago, set to improve the representation of women and minorities in ... Full text Cite

EPID-09. VARIATION IN GLIOMA INCIDENCE AMONG US HISPANICS BY GEOGRAPHIC REGION OF ORIGIN

Conference Neuro-Oncology · November 12, 2021 AbstractBACKGROUNDGlioma incidence is 25% lower in U.S. Hispanics than in White non-Hispanics. The US Hispanic population is diverse a ... Full text Cite

EPID-06. ASSOCIATIONS BETWEEN GERMLINE GENETIC VARIANTS AND OVERALL SURVIVAL IN PATIENTS WITH GLIOMA

Conference Neuro-Oncology · November 12, 2021 AbstractBACKGROUNDIn addition to somatic genetic variation in tumors, germline genetic variation can better define cancer susceptibili ... Full text Cite

BIOM-17. DIFFERENCES IN THE IMMUNE MICROENVIRONMENT OF GLIOMAS HARBORING IDH2 VERSUS IDH1 MUTATIONS

Conference Neuro-Oncology · November 12, 2021 AbstractINTRODUCTIONIDH mutations are a defining feature of lower-grade glioma and secondary glioblastoma. Approximately 95% of glioma ... Full text Cite

Epidemiologic Evaluation of Clinical Outcomes in Ethnic Minorities with Myelodysplastic Syndromes

Conference Blood · November 5, 2021 AbstractIntroduction:Myelodysplastic syndromes (MDS) are a spectrum of disorders with variable degrees of cytopenias, morphological dysplasia and risk of progression to acute ... Full text Cite

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2014-2018.

Journal Article Neuro Oncol · October 5, 2021 Featured Publication The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with the CDC and NCI, is the largest population-based registry focused exclusively on primary brain and other central nervous system (CNS) tumors in the United States (US) and ... Full text Link to item Cite

The shared genetic architecture between epidemiological and behavioral traits with lung cancer.

Journal Article Sci Rep · September 2, 2021 The complex polygenic nature of lung cancer is not fully characterized. Our study seeks to identify novel phenotypes associated with lung cancer using cross-trait linkage disequilibrium score regression (LDSR). We measured pairwise genetic correlation (rg) ... Full text Link to item Cite

Brain and other central nervous system tumor statistics, 2021.

Journal Article CA Cancer J Clin · September 2021 Featured Publication Brain and other central nervous system (CNS) tumors are among the most fatal cancers and account for substantial morbidity and mortality in the United States. Population-based data from the Central Brain Tumor Registry of the United States (a combined data ... Full text Link to item Cite

Partitioned glioma heritability shows subtype-specific enrichment in immune cells.

Journal Article Neuro Oncol · August 2, 2021 Featured Publication BACKGROUND: Epidemiological studies of adult glioma have identified genetic syndromes and 25 heritable risk loci that modify individual risk for glioma, as well increased risk in association with exposure to ionizing radiation and decreased risk in associa ... Full text Link to item Cite

The Shared Genetic Architectures Between Lung Cancer and Multiple Polygenic Phenotypes in Genome-Wide Association Studies.

Journal Article Cancer Epidemiol Biomarkers Prev · June 2021 BACKGROUND: Prior genome-wide association studies have identified numerous lung cancer risk loci and reveal substantial etiologic heterogeneity across histologic subtypes. Analyzing the shared genetic architecture underlying variation in complex traits can ... Full text Link to item Cite

Epidemiology of brainstem high-grade gliomas in children and adolescents in the United States, 2000-2017.

Journal Article Neuro Oncol · June 1, 2021 BACKGROUND: Limited population-based data exist for the brainstem gliomas for children ages ≤19 years, which includes high-grade aggressively growing tumors such as diffuse intrinsic pontine glioma (DIPG). We examined the overall incidence and survival pat ... Full text Link to item Cite

Role of Ethnicity and Geographic Location on Glioblastoma IDH1/IDH2 Mutations.

Journal Article World Neurosurg · May 2021 BACKGROUND: Previous studies have demonstrated possible differences in glioblastoma (GBM) survival attributable to ethnicity. The goal of this study was to quantify oncogenic differences and evaluate the overall survival (OS) and progression-free survival ... Full text Link to item Cite

Racial/ethnic disparities in treatment pattern and time to treatment for adults with glioblastoma in the US.

Journal Article J Neurooncol · May 2021 PURPOSE: Race/ethnicity have been previously shown to significantly affect survival after diagnosis with glioblastoma, but the cause of this survival difference is not known. The aim of this study was to examine variation in treatment pattern and time to t ... Full text Link to item Cite

A comprehensive epidemiological review of spinal astrocytomas in the United States.

Journal Article J Neurosurg Spine · February 1, 2021 OBJECTIVE: Spinal cord astrocytoma (SCA) is a rare tumor whose epidemiology has not been well defined. The authors utilized the Central Brain Tumor Registry of the United States (CBTRUS) to provide comprehensive up-to-date epidemiological data for this dis ... Full text Link to item Cite

The state of neuro-oncology during the COVID-19 pandemic: A worldwide assessment

Conference Neuro Oncology Advances · January 1, 2021 Background:It remains unknown how the COVID-19 pandemic has changed neuro-oncology clinical practice, training, and research efforts. Methods:We performed an international survey of practitioners, scientists, and trainees from 21 neuro-oncology organizatio ... Full text Cite

An updated histology recode for the analysis of primary malignant and nonmalignant brain and other central nervous system tumors in the Surveillance, Epidemiology, and End Results Program.

Journal Article Neurooncol Adv · 2021 BACKGROUND: There are over 100 histologically distinct types of primary malignant and nonmalignant brain and other central nervous system (CNS) tumors. Our study presents recent trends in the incidence of these tumors using an updated histology recode that ... Full text Link to item Cite

The state of neuro-oncology during the COVID-19 pandemic: a worldwide assessment.

Journal Article Neurooncol Adv · 2021 BACKGROUND: It remains unknown how the COVID-19 pandemic has changed neuro-oncology clinical practice, training, and research efforts. METHODS: We performed an international survey of practitioners, scientists, and trainees from 21 neuro-oncology organizat ... Full text Link to item Cite

Glioblastoma as an age-related neurological disorder in adults.

Journal Article Neurooncol Adv · 2021 BACKGROUND: Advanced age is a major risk factor for the development of many diseases including those affecting the central nervous system. Wild-type isocitrate dehydrogenase glioblastoma (IDHwt GBM) is the most common primary malignant brain cancer and acc ... Full text Open Access Link to item Cite

Brain tumor biomarkers for research, clinics, and registries - The 2021 Brain Tumor Epidemiology Consortium meeting report.

Journal Article Clin Neuropathol · 2021 The Brain Tumor Epidemiology Consortium (BTEC) is an international consortium that fosters interdisciplinary collaborations focusing on research related to the etiology, outcomes, and prevention of brain tumors. The 21st annual BTEC meeting with the theme ... Full text Link to item Cite

A Population Study of Clinical Trial Accrual for Women and Minorities in Neuro-Oncology Following the NIH Revitalization Act

Journal Article · 2021 BACKGROUND The NIH Revitalization Act, implemented 29 years ago, set to improve the representation of women and minorities in clinical trials. In this study, we investigate progress made in all phase therapeutic clinical trials for neuro-epithelia ... Full text Cite

Sex-Specific Genetic Associations for Barrett's Esophagus and Esophageal Adenocarcinoma.

Journal Article Gastroenterology · December 2020 BACKGROUND & AIMS: Esophageal adenocarcinoma (EA) and its premalignant lesion, Barrett's esophagus (BE), are characterized by a strong and yet unexplained male predominance (with a male-to-female ratio in EA incidence of up to 6:1). Genome-wide association ... Full text Link to item Cite

European genetic ancestry associated with risk of childhood ependymoma.

Journal Article Neuro Oncol · November 26, 2020 BACKGROUND: Ependymoma is a histologically defined central nervous system tumor most commonly occurring in childhood. Population-level incidence differences by race/ethnicity are observed, with individuals of European ancestry at highest risk. We aimed to ... Full text Link to item Cite

Diffusion-weighted MR imaging histogram analysis in HIV positive and negative patients with primary central nervous system lymphoma as a predictor of outcome and tumor proliferation.

Journal Article Oncotarget · November 10, 2020 INTRODUCTION: Ki-67 expression, a marker of tumor proliferation, is considered a prognostic factor in primary CNS lymphoma (PCNSL). Apparent diffusion coefficient (ADC) parameters have also been proposed as imaging biomarkers for tumor progression and prol ... Full text Link to item Cite

BIOM-50. GENETIC PREDISPOSITION TO LONGER TELOMERE LENGTH AND RISK OF CHILDHOOD, ADOLESCENT AND ADULT-ONSET EPENDYMOMA

Journal Article Neuro-Oncology · November 9, 2020 AbstractINTRODUCTIONEpendymoma is the third most common brain tumor in children, with well-described molecular characterization but po ... Full text Cite

EPCO-13. GENOME-WIDE ASSOCIATION STUDY IN INDIVIDUALS OF ASHKENAZI JEWISH ANCESTRY IDENTIFIES NOVEL RISK LOCI FOR GLIOMA

Journal Article Neuro-Oncology · November 9, 2020 AbstractPopulation stratification, or systematic differences in allele frequencies between subpopulations, can distort the results from genome-wide association studies (GWAS). While GWAS are usually conducte ... Full text Cite

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2013-2017.

Journal Article Neuro Oncol · October 30, 2020 The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with the Centers for Disease Control (CDC) and National Cancer Institute (NCI), is the largest population-based registry focused exclusively on primary brain and other central ... Full text Link to item Cite

Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma.

Journal Article Acta Neuropathol Commun · October 28, 2020 Ependymoma is the third most common brain tumor in children, with well-described molecular characterization but poorly understood underlying germline risk factors. To investigate whether genetic predisposition to longer telomere length influences ependymom ... Full text Link to item Cite

Association of metabolic syndrome with glioblastoma: a retrospective cohort study and review.

Journal Article Neurooncol Pract · October 2020 BACKGROUND: Metabolic syndrome is identified as a risk factor for the development of several systemic cancers, but its frequency among patients with glioblastoma and its association with clinical outcomes have yet to be determined. The aim of this study wa ... Full text Link to item Cite

Abstract 2327: Genetic correlation analysis identifies glioma heritability enrichment in immune cell types and novel protective associations with auto-immune conditions

Conference Cancer Research · August 15, 2020 AbstractIntroduction: Prior epidemiological studies in glioma have identified 25 germline risk variants, as well as risk association with exposure to ionizing radiation and protective association with histor ... Full text Cite

Sex Differences in Cancer Incidence and Survival: A Pan-Cancer Analysis.

Journal Article Cancer Epidemiol Biomarkers Prev · July 2020 BACKGROUND: Sex plays an important role in the incidence, prognosis, and mortality of cancers, but often is not considered in disease treatment. METHODS: We quantified sex differences in cancer incidence using the United States Cancer Statistics (USCS) pub ... Full text Link to item Cite

Testing for causality between systematically identified risk factors and glioma: a Mendelian randomization study.

Journal Article BMC Cancer · June 3, 2020 BACKGROUND: Whilst epidemiological studies have provided evidence of associations between certain risk factors and glioma onset, inferring causality has proven challenging. Using Mendelian randomization (MR), we assessed whether associations of 36 reported ... Full text Link to item Cite

Association between urbanicity and surgical treatment among patients with primary glioblastoma in the United States.

Journal Article Neurooncol Pract · June 2020 BACKGROUND: Glioblastoma (GB) is the most common and most lethal primary malignant brain tumor. Extent of surgical resection is one of the most important prognostic factors associated with improved survival. Historically, patients living in nonmetropolitan ... Full text Link to item Cite

Relative survival after diagnosis with a primary brain or other central nervous system tumor in the National Program of Cancer Registries, 2004 to 2014.

Journal Article Neurooncol Pract · June 2020 BACKGROUND: The majority of reported cancer survival statistics in the United States are generated using the National Cancer Institute's publicly available Surveillance, Epidemiology, and End Results (SEER) data, which prior to 2019 represented 28% of the ... Full text Link to item Cite

The epidemiology of spinal schwannoma in the United States between 2006 and 2014.

Journal Article J Neurosurg Spine · May 1, 2020 OBJECTIVE: Spinal schwannoma remains the third most common intradural spinal tumor following spinal meningioma and ependymoma. The available literature is generally limited to single-institution reports rather than epidemiological investigations. As of 1/1 ... Full text Link to item Cite

Association of Maximal Extent of Resection of Contrast-Enhanced and Non-Contrast-Enhanced Tumor With Survival Within Molecular Subgroups of Patients With Newly Diagnosed Glioblastoma.

Journal Article JAMA Oncol · April 1, 2020 IMPORTANCE: Per the World Health Organization 2016 integrative classification, newly diagnosed glioblastomas are separated into isocitrate dehydrogenase gene 1 or 2 (IDH)-wild-type and IDH-mutant subtypes, with median patient survival of 1.2 and 3.6 years, ... Full text Link to item Cite

Glioma risk associated with extent of estimated European genetic ancestry in African Americans and Hispanics.

Journal Article Int J Cancer · February 1, 2020 Glioma incidence is highest in non-Hispanic Whites, and to date, glioma genome-wide association studies (GWAS) to date have only included European ancestry (EA) populations. African Americans and Hispanics in the US have varying proportions of EA, African ... Full text Link to item Cite

Proteins inform survival-based differences in patients with glioblastoma.

Journal Article Neurooncol Adv · 2020 BACKGROUND: Improving the care of patients with glioblastoma (GB) requires accurate and reliable predictors of patient prognosis. Unfortunately, while protein markers are an effective readout of cellular function, proteomics has been underutilized in GB pr ... Full text Link to item Cite

Sex is an important prognostic factor for glioblastoma but not for nonglioblastoma.

Journal Article Neurooncol Pract · December 2019 BACKGROUND: Glioblastoma (GBM) is the most common and most malignant glioma. Nonglioblastoma (non-GBM) gliomas (WHO Grades II and III) are invasive and also often fatal. The goal of this study is to determine whether sex differences exist in glioma surviva ... Full text Link to item Cite

Risk factors for childhood and adult primary brain tumors.

Journal Article Neuro Oncol · November 4, 2019 Primary brain tumors account for ~1% of new cancer cases and ~2% of cancer deaths in the United States; however, they are the most commonly occurring solid tumors in children. These tumors are very heterogeneous and can be broadly classified into malignant ... Full text Link to item Cite

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012-2016.

Journal Article Neuro Oncol · November 1, 2019 The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with the Centers for Disease Control and Prevention and National Cancer Institute, is the largest population-based registry focused exclusively on primary brain and other cent ... Full text Link to item Cite

Whole Tumor Histogram Analysis Using DW MRI in Primary Central Nervous System Lymphoma Correlates with Tumor Biomarkers and Outcome.

Journal Article Cancers (Basel) · October 8, 2019 The ability to non-invasively predict outcomes and monitor treatment response in primary central nervous system lymphoma (PCNSL) is important as treatment regimens are constantly being trialed. The aim of this study was to assess the validity of using appa ... Full text Link to item Cite

Glioma incidence and survival variations by county-level socioeconomic measures.

Journal Article Cancer · October 1, 2019 BACKGROUND: Multiple studies have reported higher rates of glioma in areas with higher socioeconomic status (SES) but to the authors' knowledge have not stratified by other factors, including race/ethnicity or urban versus rural location. METHODS: The auth ... Full text Link to item Cite

Cancer collection efforts in the United States provide clinically relevant data on all primary brain and other CNS tumors.

Journal Article Neurooncol Pract · September 2019 Cancer surveillance is critical for monitoring the burden of cancer and the progress in cancer control. The accuracy of these data is important for decision makers and others who determine resource allocation for cancer prevention and research. In the Unit ... Full text Link to item Cite

The Immune Landscape of Cancer.

Journal Article Immunity · August 20, 2019 Full text Link to item Cite

Partnership for defining the impact of 12 selected rare CNS tumors: a report from the CBTRUS and the NCI-CONNECT.

Journal Article J Neurooncol · August 2019 PURPOSE: Population-based cancer statistics, including histology-specific incidence, prevalence, and survival are essential to evaluating the total burden due to disease in a population. The National Cancer Institute's (NCI) Comprehensive Oncology Network ... Full text Link to item Cite

Abstract 2745: Tumor microenvironment and host genetics impact glioma progression in a Collaborative Cross-based orthotopic allograft model

Conference Cancer Research · July 1, 2019 AbstractGliomas are diffusely invasive brain tumors with fatal outcomes and few effective treatments. Precision medicine focuses on targeting the genetics of individual tumors, but not host genetics, desp ... Full text Cite

Abstract 4173: Previously identified common glioma risk SNPs are associated with familial glioma

Conference Cancer Research · July 1, 2019 AbstractBACKGROUND: Approximately 5% of gliomas occur in individuals with a family history of glioma, and first-degree relatives of brain tumor cases have a two-fold increase in risk of brain tumor. Recen ... Full text Cite

Descriptive epidemiology of germ cell tumors of the central nervous system diagnosed in the United States from 2006 to 2015.

Journal Article J Neurooncol · June 2019 PURPOSE: Germ cell tumors (GCT) in the central nervous system (CNS) are rare tumors that occur with highest frequency in males, Asian populations, and children less than age 20 years. Due to the rarity of these tumors, their patterns of incidence are not w ... Full text Link to item Cite

Publisher Correction: Mendelian randomisation study of the relationship between vitamin D and risk of glioma.

Journal Article Sci Rep · May 23, 2019 A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ... Full text Link to item Cite

Primary central nervous system lymphoma in patients with and without HIV infection: a multicenter study and comparison with U.S national data.

Journal Article Cancer Causes Control · May 2019 PURPOSE: Primary central nervous system lymphoma (PCNSL) in patients living with HIV (PLWH) is a distinct entity; however, the management is adopted from patients without HIV. The study aims to examine the differences in presentation, treatment, and outcom ... Full text Link to item Cite

The epidemiology of central and extraventricular neurocytoma in the United States between 2006 and 2014.

Journal Article J Neurooncol · May 2019 INTRODUCTION: Central neurocytoma (CN) and extraventricular neurocytoma (EVN) are rare intracranial tumors. There is a paucity of studies reporting the population-based incidence of these tumors. We used the Central Brain Tumor Registry of the United State ... Full text Link to item Cite

Lifetime Occurrence of Brain Metastases Arising from Lung, Breast, and Skin Cancers in the Elderly: A SEER-Medicare Study.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2019 BACKGROUND: The Surveillance, Epidemiology, and End Results (SEER) Program recently released data on brain metastases (BM) diagnosed during primary cancer staging workup ("synchronous" BM, or SBM); this study examines the incidence of SBM compared with tha ... Full text Link to item Cite

Transcriptome-Wide Association Study Identifies New Candidate Susceptibility Genes for Glioma.

Journal Article Cancer Res · April 15, 2019 Genome-wide association studies (GWAS) have so far identified 25 loci associated with glioma risk, with most showing specificity for either glioblastoma (GBM) or non-GBM tumors. The majority of these GWAS susceptibility variants reside in noncoding regions ... Full text Link to item Cite

Aspirin, NSAIDs, and Glioma Risk: Original Data from the Glioma International Case-Control Study and a Meta-analysis.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2019 BACKGROUND: There have been few studies of sufficient size to address the relationship between glioma risk and the use of aspirin or NSAIDs, and results have been conflicting. The purpose of this study was to examine the associations between glioma and asp ... Full text Link to item Cite

Primary brain and other central nervous system tumors in Appalachia: regional differences in incidence, mortality, and survival.

Journal Article J Neurooncol · March 2019 BACKGROUND: The Appalachian region is a large geographic and economic area, representing 7.69% of the United States (US). This region is more rural, whiter, older, and has a higher level of poverty as compared to the rest of the US. Limited research has be ... Full text Link to item Cite

Esthesioneuroblastoma: Descriptive Epidemiology from the Central Brain Tumor Registry of the United States

Conference Journal of Neurological Surgery Part B: Skull Base · February 2019 Full text Cite

Sex-specific gene and pathway modeling of inherited glioma risk.

Journal Article Neuro Oncol · January 1, 2019 BACKGROUND: To date, genome-wide association studies (GWAS) have identified 25 risk variants for glioma, explaining 30% of heritable risk. Most histologies occur with significantly higher incidence in males, and this difference is not explained by currentl ... Full text Link to item Cite

Multiscale, multimodal analysis of tumor heterogeneity in IDH1 mutant vs wild-type diffuse gliomas.

Journal Article PLoS One · 2019 Glioma is recognized to be a highly heterogeneous CNS malignancy, whose diverse cellular composition and cellular interactions have not been well characterized. To gain new clinical- and biological-insights into the genetically-bifurcated IDH1 mutant (mt) ... Full text Link to item Cite

Epidemiology and Molecular Epidemiology.

Chapter · January 2019 Incidence, prevalence, and survival for diffuse low-grade gliomas and diffuse anaplastic gliomas (including grade II and grade III astrocytomas and oligodendrogliomas) varies by histologic type, age at diagnosis, sex, and race/ethnicity. Significant progre ... Full text Link to item Cite

Tumor cell phenotype and heterogeneity differences in IDH1 mutant vs wild-type gliomas

Journal Article · 2019 Glioma is recognized to be a highly heterogeneous CNS malignancy, whose diverse cellular composition and cellular interactions have not been well characterized. To gain new clinical- and biological-insights into the genetically-bifurcated IDH1 mutant (mt) ... Full text Cite

Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age.

Journal Article Int J Cancer · November 15, 2018 Glioblastoma (GBM) is the most common malignant brain tumor in the United States. Incidence of GBM increases with age, and younger age-at-diagnosis is significantly associated with improved prognosis. While the relationship between candidate GBM risk SNPs ... Full text Link to item Cite

Survivorship in adults with malignant brain and other central nervous system tumor from 2000-2014.

Journal Article Neuro Oncol · November 9, 2018 BACKGROUND: The goal of this study was to provide up-to-date and comprehensive statistics on incidence, survival, and prevalence rates for selected malignant brain and other CNS tumors in adults. METHODS: The current study used data from the Central Brain ... Full text Link to item Cite

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer.

Journal Article Cell Rep · October 30, 2018 Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehensive molecular characterization of 19 Hippo core genes in 9,125 tumor samples across 33 cancer types using multidimensional "omic" data from The Cancer Genom ... Full text Link to item Cite

A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily.

Journal Article Cell Syst · October 24, 2018 We present an integromic analysis of gene alterations that modulate transforming growth factor β (TGF-β)-Smad-mediated signaling in 9,125 tumor samples across 33 cancer types in The Cancer Genome Atlas (TCGA). Focusing on genes that encode mediators and re ... Full text Link to item Cite

A comparison of relative survival and cause-specific survival methods to measure net survival in cancer populations.

Journal Article Cancer Med · September 2018 BACKGROUND: Accurate cancer survival statistics are necessary for describing population-level survival patterns and measuring advancements in cancer care. Net cancer survival is measured using two methods: cause-specific survival (CSS) and relative surviva ... Full text Link to item Cite

Adult Glioma Incidence and Survival by Race or Ethnicity in the United States From 2000 to 2014.

Journal Article JAMA Oncol · September 1, 2018 IMPORTANCE: Glioma is the most commonly occurring malignant brain tumor in the United States, and its incidence varies by age, sex, and race or ethnicity. Survival after brain tumor diagnosis has been shown to vary by these factors. OBJECTIVE: To quantify ... Full text Link to item Cite

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients.

Journal Article Cancer Cell · August 13, 2018 Our comprehensive analysis of alternative splicing across 32 The Cancer Genome Atlas cancer types from 8,705 patients detects alternative splicing events and tumor variants by reanalyzing RNA and whole-exome sequencing data. Tumors have up to 30% more alte ... Full text Link to item Cite

Abstract 4220: Heterogeneous distribution of prognostic protein markers in glioblastoma

Conference Cancer Research · July 1, 2018 AbstractBackground: Glioblastoma (GBM) is the most common and lethal primary malignant brain tumor in adults. The heterogeneity of the disease leads to significant variability in response to standard therapy ... Full text Cite

Abstract 233: Evaluating glioma risk associated with extent of European admixture in African-Americans and Latinos

Conference Cancer Research · July 1, 2018 AbstractGlioma incidence is highest in non-Hispanic Whites, where it occurs ~2x as frequently compared with other race/ethnicity groups. Glioma GWAS to date have included European ancestry populations only, ... Full text Cite

Models of epigenetic age capture patterns of DNA methylation in glioma associated with molecular subtype, survival, and recurrence.

Journal Article Neuro Oncol · June 18, 2018 BACKGROUND: Models of epigenetic aging (epigenetic clocks) have been implicated as potentially useful markers for cancer risk and prognosis. Using 2 previously published methods for modeling epigenetic age, Horvath's clock and epiTOC, we investigated epige ... Full text Link to item Cite

Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.

Journal Article Sci Rep · May 9, 2018 Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma genome-wide association studie ... Full text Link to item Cite

The Immune Landscape of Cancer.

Journal Article Immunity · April 17, 2018 We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified six immune subtypes-wound healing, IFN-γ dominant, inflammatory, lymphocyt ... Full text Link to item Cite

Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas.

Journal Article Cancer Cell · April 9, 2018 We analyzed 921 adenocarcinomas of the esophagus, stomach, colon, and rectum to examine shared and distinguishing molecular characteristics of gastrointestinal tract adenocarcinomas (GIACs). Hypermutated tumors were distinct regardless of cancer type and c ... Full text Link to item Cite

lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer.

Journal Article Cancer Cell · April 9, 2018 We characterized the epigenetic landscape of genes encoding long noncoding RNAs (lncRNAs) across 6,475 tumors and 455 cancer cell lines. In stark contrast to the CpG island hypermethylation phenotype in cancer, we observed a recurrent hypomethylation of 1, ... Full text Link to item Cite

Genomic and Functional Approaches to Understanding Cancer Aneuploidy.

Journal Article Cancer Cell · April 9, 2018 Aneuploidy, whole chromosome or chromosome arm imbalance, is a near-universal characteristic of human cancers. In 10,522 cancer genomes from The Cancer Genome Atlas, aneuploidy was correlated with TP53 mutation, somatic mutation rate, and expression of pro ... Full text Link to item Cite

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers.

Journal Article Cancer Cell · April 9, 2018 We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of four gynecological types plus breast. Our aims were to identify shared and unique molecular features, clinically significant subtypes, and potential therapeutic targets. We f ... Full text Link to item Cite

The elderly left behind-changes in survival trends of primary central nervous system lymphoma over the past 4 decades.

Journal Article Neuro Oncol · April 9, 2018 BACKGROUND: There has been significant improvement in treatment outcomes of primary central nervous system lymphoma (PCNSL) at specialized centers over the past several decades; however, it is unclear if these changes have translated to benefits in the gen ... Full text Link to item Cite

Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.

Journal Article Cell · April 5, 2018 The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of diverse genomic alterations underlying human cancers. At this historic junction marking the completion of genomic characterization of over 11,000 tumors from 33 cancer types, we pr ... Full text Link to item Cite

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.

Journal Article Cell · April 5, 2018 We conducted comprehensive integrative molecular analyses of the complete set of tumors in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and representing 33 types of cancer. We performed molecular clustering using data on chr ... Full text Link to item Cite

Pathogenic Germline Variants in 10,389 Adult Cancers.

Journal Article Cell · April 5, 2018 We conducted the largest investigation of predisposition variants in cancer to date, discovering 853 pathogenic or likely pathogenic variants in 8% of 10,389 cases from 33 cancer types. Twenty-one genes showed single or cross-cancer associations, including ... Full text Link to item Cite

A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples.

Journal Article Cell · April 5, 2018 The role of enhancers, a key class of non-coding regulatory DNA elements, in cancer development has increasingly been appreciated. Here, we present the detection and characterization of a large number of expressed enhancers in a genome-wide analysis of 892 ... Full text Link to item Cite

Oncogenic Signaling Pathways in The Cancer Genome Atlas.

Journal Article Cell · April 5, 2018 Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tu ... Full text Link to item Cite

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation.

Journal Article Cell · April 5, 2018 Cancer progression involves the gradual loss of a differentiated phenotype and acquisition of progenitor and stem-cell-like features. Here, we provide novel stemness indices for assessing the degree of oncogenic dedifferentiation. We used an innovative one ... Full text Link to item Cite

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics.

Journal Article Cell · April 5, 2018 For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features represe ... Full text Link to item Cite

Comprehensive Characterization of Cancer Driver Genes and Mutations.

Journal Article Cell · April 5, 2018 Identifying molecular cancer drivers is critical for precision oncology. Multiple advanced algorithms to identify drivers now exist, but systematic attempts to combine and optimize them on large datasets are few. We report a PanCancer and PanSoftware analy ... Full text Link to item Cite

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma.

Journal Article Cell Rep · April 3, 2018 Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, includ ... Full text Link to item Cite

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context.

Journal Article Cell Rep · April 3, 2018 Long noncoding RNAs (lncRNAs) are commonly dysregulated in tumors, but only a handful are known to play pathophysiological roles in cancer. We inferred lncRNAs that dysregulate cancer pathways, oncogenes, and tumor suppressors (cancer genes) by modeling th ... Full text Link to item Cite

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.

Journal Article Cell Rep · April 3, 2018 Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% validation ra ... Full text Link to item Cite

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images.

Journal Article Cell Rep · April 3, 2018 Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumor-infiltrating lymphocytes (TILs) based on H&E images from 13 TCGA t ... Full text Link to item Cite

Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers.

Journal Article Cell Rep · April 3, 2018 Metabolic reprogramming provides critical information for clinical oncology. Using molecular data of 9,125 patient samples from The Cancer Genome Atlas, we identified tumor subtypes in 33 cancer types based on mRNA expression patterns of seven major metabo ... Full text Link to item Cite

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas.

Journal Article Cell Rep · April 3, 2018 This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smoking and/or human papillomavirus (HPV). SCCs harbor 3q, 5p, and other recu ... Full text Link to item Cite

Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types.

Journal Article Cell Rep · April 3, 2018 Protein ubiquitination is a dynamic and reversible process of adding single ubiquitin molecules or various ubiquitin chains to target proteins. Here, using multidimensional omic data of 9,125 tumor samples across 33 cancer types from The Cancer Genome Atla ... Full text Link to item Cite

Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas.

Journal Article Cell Rep · April 3, 2018 Precision oncology uses genomic evidence to match patients with treatment but often fails to identify all patients who may respond. The transcriptome of these "hidden responders" may reveal responsive molecular states. We describe and evaluate a machine-le ... Full text Link to item Cite

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types.

Journal Article Cell Rep · April 3, 2018 Hotspot mutations in splicing factor genes have been recently reported at high frequency in hematological malignancies, suggesting the importance of RNA splicing in cancer. We analyzed whole-exome sequencing data across 33 tumor types in The Cancer Genome ... Full text Link to item Cite

Systematic Analysis of Splice-Site-Creating Mutations in Cancer.

Journal Article Cell Rep · April 3, 2018 For the past decade, cancer genomic studies have focused on mutations leading to splice-site disruption, overlooking those having splice-creating potential. Here, we applied a bioinformatic tool, MiSplice, for the large-scale discovery of splice-site-creat ... Full text Link to item Cite

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas.

Journal Article Cell Rep · April 3, 2018 DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types. Mutations with accompanying loss of heter ... Full text Link to item Cite

Influence of obesity-related risk factors in the aetiology of glioma.

Journal Article Br J Cancer · April 2018 BACKGROUND: Obesity and related factors have been implicated as possible aetiological factors for the development of glioma in epidemiological observation studies. We used genetic markers in a Mendelian randomisation framework to examine whether obesity-re ... Full text Link to item Cite

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas.

Journal Article Cell Syst · March 28, 2018 Although the MYC oncogene has been implicated in cancer, a systematic assessment of alterations of MYC, related transcription factors, and co-regulatory proteins, forming the proximal MYC network (PMN), across human cancers is lacking. Using computational ... Full text Link to item Cite

Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines.

Journal Article Cell Syst · March 28, 2018 The Cancer Genome Atlas (TCGA) cancer genomics dataset includes over 10,000 tumor-normal exome pairs across 33 different cancer types, in total >400 TB of raw data files requiring analysis. Here we describe the Multi-Center Mutation Calling in Multiple Can ... Full text Link to item Cite

Impact of atopy on risk of glioma: a Mendelian randomisation study.

Journal Article BMC Med · March 15, 2018 BACKGROUND: An inverse relationship between allergies with glioma risk has been reported in several but not all epidemiological observational studies. We performed an analysis of genetic variants associated with atopy to assess the relationship with glioma ... Full text Link to item Cite

Mendelian randomisation study of the relationship between vitamin D and risk of glioma.

Journal Article Sci Rep · February 5, 2018 To examine for a causal relationship between vitamin D and glioma risk we performed an analysis of genetic variants associated with serum 25-hydroxyvitamin D (25(OH)D) levels using Mendelian randomisation (MR), an approach unaffected by biases from confoun ... Full text Link to item Cite

Brain metastases: epidemiology.

Chapter · 2018 Brain metastases (BM) are the most commonly diagnosed type of central nervous system tumor in the United States. Estimates of the frequency of BM vary significantly, as there is no nationwide reporting system for metastases. BM may be the first sign of a p ... Full text Link to item Cite

Epidemiology of Intracranial Gliomas.

Journal Article Prog Neurol Surg · 2018 Gliomas are the most common primary intracranial neoplasms, which cause significant mortality and morbidity that is disproportionate to their relatively rare incidence. Many potential risk factors for glioma have been studied to date, but only few provide ... Full text Link to item Cite

Incidence and survival trends for medulloblastomas in the United States from 2001 to 2013.

Journal Article J Neurooncol · December 2017 Population-based data examining recent epidemiological trends in medulloblastoma, the most common pediatric brain malignancy, are limited. Therefore, we sought to examine recent population-level trends in medulloblastoma incidence and survival. Central Bra ... Full text Link to item Cite

Brain tumor biobanking in the precision medicine era: building a high-quality resource for translational research in neuro-oncology.

Journal Article Neurooncol Pract · December 2017 The growth of precision medicine has made access to biobanks with high-quality, well-annotated neuro-oncology biospecimens critical. Developing and maintaining neuro-oncology biobanks is best accomplished through multidisciplinary collaboration between cli ... Full text Link to item Cite

Global incidence of malignant brain and other central nervous system tumors by histology, 2003-2007.

Journal Article Neuro Oncol · October 19, 2017 BACKGROUND: Previous reports have shown that overall incidence of malignant brain and other central nervous system (CNS) tumors varied significantly by country. The aim of this study was to estimate histology-specific incidence rates by global region and a ... Full text Link to item Cite

Prognostic significance of preoperative neutrophilia on recurrence-free survival in meningioma.

Journal Article Neuro Oncol · October 19, 2017 BACKGROUND: Meningioma is the most common primary intracranial tumor and recurrence is one of the important challenges in patient management. Prognostic factors for tumor recurrences in these patients especially before surgical resection are not fully char ... Full text Link to item Cite

Do race and age vary in non-malignant central nervous system tumor incidences in the United States?

Journal Article J Neurooncol · September 2017 Epidemiological analyses of many cancers have demonstrated differences in incidence and outcome for patients from different racial backgrounds. The aim of this study was to determine the incidence of non-malignant CNS tumors by race and age to identify inc ... Full text Link to item Cite

Estimating the annual frequency of synchronous brain metastasis in the United States 2010-2013: a population-based study.

Journal Article J Neurooncol · August 2017 Brain metastases (BM) are one of the most common types of brain tumors and are a relatively common event in the disease process for several high-incidence cancer types, including breast and lung cancers. Historically, information on metastases including BM ... Full text Link to item Cite

Abstract 1315: Estimating sex-specific effects of genetic loci associated with glioma risk

Conference Cancer Research · July 1, 2017 AbstractBACKGROUND: Incidence of glioma varies significantly by sex, and most glioma histologies occur with greater incidence in males. Previous analyses have examined the impact of estrogen exposure as a ri ... Full text Cite

Abstract 1302: Genome-wide association study of glioma reveals specific differences in genetic susceptibility to glioblastoma and non-glioblastoma

Conference Cancer Research · July 1, 2017 AbstractBACKGROUND: Glioma accounts for ~27% of all primary brain tumors and is responsible for ~13,000 cancer-related deaths in the US each year. Glioma tumors can be broadly classified into glioblastoma (G ... Full text Cite

Integrated genomic analysis of survival outliers in glioblastoma.

Journal Article Neuro Oncol · June 1, 2017 BACKGROUND: To elucidate molecular features associated with disproportionate survival of glioblastoma (GB) patients, we conducted deep genomic comparative analysis of a cohort of patients receiving standard therapy (surgery plus concurrent radiation and te ... Full text Link to item Cite

Is mortality due to primary malignant brain and other central nervous system tumors decreasing?

Journal Article J Neurooncol · June 2017 Primary malignant brain and other central nervous system tumors (BT) are a rare cancer that causes morbidity and mortality disproportionate to their incidence. This study presents the most up-to-date mortality data for malignant BT in the United States (US ... Full text Link to item Cite

Corrigendum.

Journal Article Neurooncol Pract · June 2017 [This corrects the article DOI: 10.1093/nop/npw029.]. ... Full text Link to item Cite

Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.

Journal Article Nat Genet · May 2017 Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 ca ... Full text Link to item Cite

Complete prevalence of malignant primary brain tumors registry data in the United States compared with other common cancers, 2010.

Journal Article Neuro Oncol · May 1, 2017 BACKGROUND: Complete prevalence proportions illustrate the burden of disease in a population. This study estimates the 2010 complete prevalence of malignant primary brain tumors overall and by Central Brain Tumor Registry of the United States (CBTRUS) hist ... Full text Link to item Cite

Incidence and survival trends in oligodendrogliomas and anaplastic oligodendrogliomas in the United States from 2000 to 2013: a CBTRUS Report.

Journal Article J Neurooncol · May 2017 Measuring tumor-specific trends in incidence is necessary to elucidate tumor-type contribution to overall cancer burden in the US population. Recently, there have been conflicting reports concerning the incidence of oligodendrogliomas (OD) and anaplastic o ... Full text Link to item Cite

Sex-specific gene and pathway modeling of inherited glioma risk

Journal Article · 2017 ABSTRACTBackground Genome-wide association studies (GWAS) have identified 25 risk variants for glioma, which explain ~30% of heritable risk. Most glioma histologies occur with significantly higher incidence in males. A sex-stratified ana ... Full text Cite

Sex-specific genome-wide association study in glioma identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21

Journal Article · 2017 Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma genome-wide association studie ... Full text Cite

Nervous system

Chapter · January 1, 2017 Although brain and other nervous system tumors are relatively rare, constituting up to 4% of incident primary cancer diagnoses, they are often associated with high morbidity and mortality. Several etiologic factors have been examined in relation to nervous ... Full text Cite

Completeness of required site-specific factors for brain and CNS tumors in the Surveillance, Epidemiology and End Results (SEER) 18 database (2004-2012, varying).

Journal Article J Neurooncol · October 2016 Cancer registries are an important source of population-level information on brain tumor incidence and survival. Surveillance, Epidemiology, and End Results (SEER) registries currently collect data on specific required factors related to brain tumors as de ... Full text Link to item Cite

Abstract 129: Integrated genomic analysis of survival outliers in glioblastoma

Conference Cancer Research · July 15, 2016 AbstractDespite the general poor prognosis for patients with GBM, a proportion survives well beyond the median survival of 12-14 months following diagnosis. To elucidate molecular features associated with di ... Full text Cite

Conditional survival after diagnosis with malignant brain and central nervous system tumor in the United States, 1995-2012.

Journal Article J Neurooncol · July 2016 General population-based survival statistics for primary malignant brain or other central nervous system (CNS) tumors do not provide accurate estimations of prognosis for individuals who have survived for a significant period of time. For these persons, th ... Full text Link to item Cite

Understanding inherited genetic risk of adult glioma - a review.

Journal Article Neurooncol Pract · March 2016 During the past six years, researchers have made major progress identifying common inherited genetic variation that increases risk for primary adult glioma. This paper summarizes knowledge about rare familial cancer syndromes that include adult glioma and ... Full text Link to item Cite

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.

Journal Article Cell · January 28, 2016 Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic glioma driving alterations and suboptimal disease classification. We defined the complete set of genes associated with 1,122 diffuse grade II-III-IV gliomas from Th ... Full text Link to item Cite

Years of potential life lost for brain and CNS tumors relative to other cancers in adults in the United States, 2010.

Journal Article Neuro Oncol · January 2016 BACKGROUND: Years of potential life lost (YPLL) complement incidence and survival rates by measuring how much a patient's life is likely to be shortened by his or her cancer. In this study, we examine the impact of death due to brain and other central nerv ... Full text Link to item Cite

Comparative Brain and Central Nervous System Tumor Incidence and Survival between the United States and Taiwan Based on Population-Based Registry.

Journal Article Front Public Health · 2016 PURPOSE: Reasons for worldwide variability in the burden of primary malignant brain and central nervous system (CNS) tumors remain unclear. This study compares the incidence and survival of malignant brain and CNS tumors by selected histologic types betwee ... Full text Link to item Cite

Incidence of vestibular schwannomas in the United States.

Journal Article J Neurooncol · September 2015 There is a paucity of population-based data evaluating the incidence of vestibular schwannomas according to age, gender, race, and ethnicity. Such data are necessary to assess the burden of vestibular schwannomas on varying populations and to inform future ... Full text Link to item Cite

Descriptive Epidemiology of Spinal Meningiomas in the United States.

Journal Article Spine (Phila Pa 1976) · August 1, 2015 STUDY DESIGN: Cross-sectional study of US cancer registry data. OBJECTIVE: To present the current population-based descriptive epidemiology of spinal meningiomas in the United States. SUMMARY OF BACKGROUND DATA: Meningioma is the most common primary spinal ... Full text Link to item Cite

Descriptive epidemiology of World Health Organization grades II and III intracranial meningiomas in the United States.

Journal Article Neuro Oncol · August 2015 BACKGROUND: Because World Health Organization (WHO) grades II and III meningiomas are relatively uncommon, there is limited literature on the descriptive epidemiology of these tumors, and the existing literature predates the 2000 WHO classification revisio ... Full text Link to item Cite

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

Journal Article N Engl J Med · June 25, 2015 BACKGROUND: Diffuse low-grade and intermediate-grade gliomas (which together make up the lower-grade gliomas, World Health Organization grades II and III) have highly variable clinical behavior that is not adequately predicted on the basis of histologic cl ... Full text Link to item Cite

Completeness and concordancy of WHO grade assignment for brain and central nervous system tumors in the United States, 2004-2011.

Journal Article J Neurooncol · May 2015 Central nervous system (CNS) tumors are categorized and graded for clinical and research purposes according to the World Health Organization (WHO) scheme which segregates tumors by histological type and predicted biological behavior. However, reporting of ... Full text Link to item Cite

Years of life lived with disease and years of potential life lost in children who die of cancer in the United States, 2009.

Journal Article Cancer Med · April 2015 Incidence and survival rates are commonly reported statistics, but these may fail to capture the full impact of childhood cancers. We describe the years of potential life lost (YPLL) and years of life lived with disease (YLLD) in children and adolescents w ... Full text Link to item Cite

Trends in central nervous system tumor incidence relative to other common cancers in adults, adolescents, and children in the United States, 2000 to 2010.

Journal Article Cancer · January 1, 2015 BACKGROUND: Time trends in cancer incidence rates (IR) are important to measure the changing burden of cancer on a population over time. The overall IR of cancer in the United States is declining. Although central nervous system tumors (CNST) are rare, the ... Full text Link to item Cite

Epidemiology of gliomas.

Chapter · 2015 Gliomas are the most common type of primary intracranial tumors. Some glioma subtypes cause significant mortality and morbidity that are disproportionate to their relatively rare incidence. A very small proportion of glioma cases can be attributed to inher ... Full text Link to item Cite

Alex's Lemonade Stand Foundation Infant and Childhood Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2007-2011.

Journal Article Neuro Oncol · January 2015 The CBTRUS Statistical Report: Alex's Lemonade Stand Foundation Infant and Childhood Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2007–2011 comprehensively describes the current population-based incidence of primary mal ... Full text Link to item Cite

International Differences in Treatment and Clinical Outcomes for High Grade Glioma.

Journal Article PLoS One · 2015 BACKGROUND: High grade gliomas are the most common type of malignant brain tumor, and despite their rarity, cause significant morbidity and mortality. This study aimed to compare the treatment patterns of high grade glioma to examine survival patterns in p ... Full text Link to item Cite

Childhood brain tumor epidemiology: a brain tumor epidemiology consortium review.

Journal Article Cancer Epidemiol Biomarkers Prev · December 2014 Childhood brain tumors are the most common pediatric solid tumor and include several histologic subtypes. Although progress has been made in improving survival rates for some subtypes, understanding of risk factors for childhood brain tumors remains limite ... Full text Link to item Cite

Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer.

Journal Article Neuro Oncol · October 2014 BACKGROUND: Although familial susceptibility to glioma is known, the genetic basis for this susceptibility remains unidentified in the majority of glioma-specific families. An alternative approach to identifying such genes is to examine cancer pedigrees, w ... Full text Link to item Cite

The descriptive epidemiology of atypical teratoid/rhabdoid tumors in the United States, 2001-2010.

Journal Article Neuro Oncol · October 2014 BACKGROUND: Atypical teratoid/rhabdoid tumor is a rare malignant CNS tumor that most often affects children ≤ 3 years old. The Central Brain Tumor Registry of the United States contains the largest aggregation of population-based incidence data for primary ... Full text Link to item Cite

Epidemiologic and molecular prognostic review of glioblastoma.

Journal Article Cancer Epidemiol Biomarkers Prev · October 2014 Glioblastoma multiforme (GBM) is the most common and aggressive primary central nervous system malignancy with a median survival of 15 months. The average incidence rate of GBM is 3.19/100,000 population, and the median age of diagnosis is 64 years. Incide ... Full text Link to item Cite

Descriptive epidemiology of pituitary tumors in the United States, 2004-2009.

Journal Article J Neurosurg · September 2014 OBJECT: Pituitary tumors are abnormal growths that develop in the pituitary gland. The Central Brain Tumor Registry of the United States (CBTRUS) contains the largest aggregation of population-based data on the incidence of primary CNS tumors in the US. Th ... Full text Link to item Cite

The epidemiology of glioma in adults: a "state of the science" review.

Journal Article Neuro Oncol · July 2014 Gliomas are the most common primary intracranial tumor, representing 81% of malignant brain tumors. Although relatively rare, they cause significant mortality and morbidity. Glioblastoma, the most common glioma histology (∼45% of all gliomas), has a 5-year ... Full text Link to item Cite

Erratum

Journal Article Neuro-Oncology · May 1, 2014 Full text Cite

Genome-wide methylation analyses in glioblastoma multiforme.

Journal Article PLoS One · 2014 Few studies had investigated genome-wide methylation in glioblastoma multiforme (GBM). Our goals were to study differential methylation across the genome in gene promoters using an array-based method, as well as repetitive elements using surrogate global m ... Full text Link to item Cite

Gene markers in brain tumors: what the epileptologist should know.

Journal Article Epilepsia · December 2013 Gene markers or biomarkers can be used for diagnostic or prognostic purposes for all different types of complex disease, including brain tumors. Prognostic markers can be useful to explain differences not only in overall survival but also in response to tr ... Full text Link to item Cite

The somatic genomic landscape of glioblastoma.

Journal Article Cell · October 10, 2013 We describe the landscape of somatic genomic alterations based on multidimensional and comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify several novel mutated genes as well as complex rearrangements of signature recept ... Full text Link to item Cite

Methylation markers of malignant potential in meningiomas.

Journal Article J Neurosurg · October 2013 OBJECT: Although most meningiomas are benign, about 20% are atypical (Grade II or III) and have increased mortality and morbidity. Identifying tumors with greater malignant potential can have significant clinical value. This validated genome-wide methylati ... Full text Link to item Cite

Family history of cancer in benign brain tumor subtypes versus gliomas.

Journal Article Front Oncol · 2012 PURPOSE: Family history is associated with gliomas, but this association has not been established for benign brain tumors. Using information from newly diagnosed primary brain tumor patients, we describe patterns of family cancer histories in patients with ... Full text Link to item Cite

Current state of our knowledge on brain tumor epidemiology.

Journal Article Curr Neurol Neurosci Rep · June 2011 The overall incidence of brain tumors for benign and malignant tumors combined is 18.71 per 100,000 person-years; 11.52 per 100,000 person-years for benign tumors and 7.19 per 100,000 person-years for malignant tumors. Incidence, response to treatment, and ... Full text Link to item Cite

Incidence patterns for primary malignant spinal cord gliomas: a Surveillance, Epidemiology, and End Results study.

Journal Article J Neurosurg Spine · June 2011 OBJECT: Primary malignant spinal glioma represents a significant clinical challenge due to the devastating effect on clinical outcomes in the majority of cases. As they are infrequently encountered in any one center, there has been limited population-based ... Full text Link to item Cite