Scholars@Duke
Rodger Alan Liddle

Rodger Alan Liddle

Professor of Medicine
Medicine, Gastroenterology
rodger.liddle@duke.edu
Duke Box 103859, 1033A GSRB-1, Durham, NC 27710
1033A GSRB-1 Bldg, Durham, NC 27710

Selected Publications

Mechanisms and clinical implications of gut-brain interactions.

Journal Article J Clin Invest · January 2, 2026 Connections between the digestive system and the brain have been postulated for over 2000 years. Despite this, only recently have specific mechanisms of gut-brain interaction been identified. Due in large part to increased interest in the microbiome, the w ... Full text Link to item Cite

Loss of TRPV4 reduces pancreatic cancer growth and metastasis.

Journal Article JCI Insight · December 8, 2025 Pancreatic ductal adenocarcinoma (PDAC) is a rapidly metastasizing cancer characterized by a dense desmoplastic stroma composed of extracellular matrix (ECM) proteins, which complicates treatment. Upon stimulation, pancreatic stellate cells (PSCs) differen ... Full text Link to item Cite

Identification of intestinal enteroendocrine cell subtypes and their associated hormones in zebrafish.

Journal Article PLoS Biol · December 2025 Enteroendocrine cells (EECs) are rare sensory cells in the intestinal epithelium that coordinate digestive physiology by secreting a diverse repertoire of peptide hormones. These hormones are the main effectors of EEC function, and their characterization r ... Full text Link to item Cite

Phosphate Improves Mitochondrial Function and Reduces Pancreatitis in Hypertriglyceridemia.

Journal Article FASEB J · August 31, 2025 Hypertriglyceridemia-associated pancreatitis (HTGP) accounts for 9% to 10% of acute pancreatitis; however, the exact cause and associated factors advancing HTGP are unclear. Clinical studies have revealed that hypophosphatemia is a common factor in many pa ... Full text Link to item Cite

Piezo1-induced durotaxis of pancreatic stellate cells depends on TRPC1 and TRPV4 channels.

Journal Article J Cell Sci · April 15, 2025 Pancreatic stellate cells (PSCs) are primarily responsible for producing the stiff tumor tissue in pancreatic ductal adenocarcinoma (PDAC). Thereby, PSCs generate a stiffness gradient between the healthy pancreas and the tumor. This gradient induces durota ... Full text Link to item Cite

Lewy body diseases and the gut.

Journal Article Mol Neurodegener · January 30, 2025 Gastrointestinal (GI) involvement in Lewy body diseases (LBDs) has been observed since the initial descriptions of patients by James Parkinson. Recent experimental and human observational studies raise the possibility that pathogenic alpha-synuclein (⍺-syn ... Full text Link to item Cite

LRG1 inhibition promotes acute pancreatitis recovery by inducing cholecystokinin Type 1 receptor expression via Akt.

Journal Article Theranostics · 2025 Rationale: Acute pancreatitis (AP) is a common gastrointestinal disease affecting nearly 3 million people annually worldwide. Although AP is typically self-limiting, up to 20% of patients may develop life-threatening complications. Individuals who suffer f ... Full text Link to item Cite

Intestinal cholecystokinin secretion

Chapter · January 1, 2025 Cholecystokinin (CCK) is produced in the gastrointestinal tract and brain. In the intestine, the hormone is produced by specialized mucosal enteroendocrine cells, which have their apical end exposed to the intestinal lumen. Ingested food molecules, such as ... Full text Cite

Early Hypophosphatemia as a Prognostic Marker in Acute Pancreatitis.

Journal Article Pancreas · August 1, 2024 OBJECTIVES: Acute pancreatitis (AP) is a complex disease representing a significant portion of gastrointestinal-related hospitalizations in the U.S. Understanding risk factors of AP might provide attractive therapeutic targets. We evaluated hypophosphatemi ... Full text Link to item Cite

Hypophosphatemia as a Predictor of Clinical Outcomes in Acute Pancreatitis: A Retrospective Study.

Journal Article Pancreas · January 1, 2024 OBJECTIVE: Phosphate is crucial for cellular repair after injury and may be important in recovery following acute pancreatitis (AP). This study aimed to evaluate the association between hypophosphatemia and severity of AP. METHODS: Patients admitted with A ... Full text Link to item Cite

Mechanosensing Piezo channels in gastrointestinal disorders.

Journal Article J Clin Invest · October 2, 2023 All cells in the body are exposed to physical force in the form of tension, compression, gravity, shear stress, or pressure. Cells convert these mechanical cues into intracellular biochemical signals; this process is an inherent property of all cells and i ... Full text Link to item Cite

Guanylyl cyclase C ameliorates visceral pain: an unsuspected link.

Journal Article J Clin Invest · February 15, 2023 Visceral pain associated with irritable bowel syndrome afflicts 15% of the US population. Although treatments are limited, guanylyl cyclase C (GUCY2C) agonists alleviate pain and constipation. Until now, it was assumed that the activation of GUCY2C and pro ... Full text Link to item Cite

Nicotinic stimulation of splenic T cells is protective in endoscopic retrograde cholangiopancreatography-induced acute pancreatitis in mice.

Journal Article Am J Physiol Gastrointest Liver Physiol · November 1, 2022 It has previously been shown that current smoking is protective against endoscopic retrograde cholangiopancreatography (ERCP)-induced acute pancreatitis, but the mechanism of this effect was not identified. We tested the hypothesis that nicotine is the act ... Full text Link to item Cite

Initiation and severity of experimental pancreatitis are modified by phosphate.

Journal Article Am J Physiol Gastrointest Liver Physiol · June 1, 2022 Proper mitochondrial function and adequate cellular ATP are necessary for normal pancreatic protein synthesis and sorting, maintenance of intracellular organelles and enzyme secretion. Inorganic phosphate is required for generating ATP and its limited avai ... Full text Link to item Cite

Piezo1-mediated stellate cell activation causes pressure-induced pancreatic fibrosis in mice.

Journal Article JCI Insight · April 22, 2022 Pancreatic fibrosis is a complication of chronic pancreatitis and is a prominent feature of pancreatic cancer. Pancreatic fibrosis is commonly observed in patients with prolonged pancreatic duct obstruction, which elevates intrapancreatic pressure. We show ... Full text Link to item Cite

Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia.

Journal Article PLoS One · 2022 OBJECTIVE: Immunoglobulin-like Domain-Containing Receptor 1 (ILDR1) is expressed on nutrient sensing cholecystokinin-positive enteroendocrine cells of the gastrointestinal tract and it has the unique ability to induce fat-mediated CCK secretion. However, t ... Full text Link to item Cite

The Role of Phosphate in Alcohol-Induced Experimental Pancreatitis.

Journal Article Gastroenterology · September 2021 BACKGROUND & AIMS: Heavy alcohol consumption is a common cause of acute pancreatitis; however, alcohol abuse does not always result in clinical pancreatitis. As a consequence, the factors responsible for alcohol-induced pancreatitis are not well understood ... Full text Link to item Cite

Heterogeneity in α-synuclein fibril activity correlates to disease phenotypes in Lewy body dementia.

Journal Article Acta Neuropathol · April 2021 α-Synuclein aggregation underlies pathological changes in Lewy body dementia. Recent studies highlight structural variabilities associated with α-synuclein aggregates in patient populations. Here, we develop a quantitative real-time quaking-induced convers ... Full text Link to item Cite

Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways.

Journal Article Cell Host Microbe · February 10, 2021 The intestinal epithelium senses nutritional and microbial stimuli using epithelial sensory enteroendocrine cells (EEC). EECs communicate nutritional information to the nervous system, but whether they also relay signals from intestinal microbes remains un ... Full text Link to item Cite

Chemical pancreatectomy: an unconventional approach to preventing autodigestion in pancreatitis.

Journal Article J Clin Invest · February 1, 2021 Due to progressive inflammation, chronic pancreatitis destroys both the exocrine and endocrine pancreas and sensitizes pancreatic nerves, leading to unremitting pain. Unfortunately, there are no treatments for pancreatic inflammation and approaches to amel ... Full text Link to item Cite

Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress.

Journal Article J Biol Chem · 2021 The ion channels Piezo1 and TRPV4 have both, independently, been implicated in high venous pressure- and fluid shear stress-induced vascular hyperpermeability in endothelial cells. However, the mechanism by which Piezo1 and TRPV4 channels execute the same ... Full text Link to item Cite

Pressure-sensing Piezo1: the eyes have it.

Journal Article J Physiol · January 2021 Full text Link to item Cite

TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation.

Journal Article J Clin Invest · May 1, 2020 Elevated pressure in the pancreatic gland is the central cause of pancreatitis following abdominal trauma, surgery, endoscopic retrograde cholangiopancreatography, and gallstones. In the pancreas, excessive intracellular calcium causes mitochondrial dysfun ... Full text Link to item Cite

Gut Sensory Transduction

Chapter · January 1, 2020 Nutrient assimilation is essential for life and is regulated by a complex system that coordinates the ingestion, absorption, and digestion of food. Central to this process is the body’s ability to assess its nutritional needs and adjust food intake to meet ... Full text Cite

High fat diet induces microbiota-dependent silencing of enteroendocrine cells.

Journal Article Elife · December 3, 2019 Enteroendocrine cells (EECs) are specialized sensory cells in the intestinal epithelium that sense and transduce nutrient information. Consumption of dietary fat contributes to metabolic disorders, but EEC adaptations to high fat feeding were unknown. Here ... Full text Link to item Cite

1089 Hypophosphatemia in Patients With Alcoholic Hepatitis

Conference American Journal of Gastroenterology · October 2019 INTRODUCTION:Patients with alcoholic hepatitis suffer from high rates of malnutrition and are at risk for hypophosphatemia due to poor dietary intake, renal wasting, and refeeding syndrom ... Full text Cite

Neuropods.

Journal Article Cell Mol Gastroenterol Hepatol · 2019 Enteroendocrine cells (EECs) are sensory cells of the gastrointestinal tract. Most EECs reside in the mucosal lining of the stomach or intestine and sense food in the gut lumen. Food signals stimulate the release of hormones into the paracellular space whe ... Full text Link to item Cite

Parkinson's disease from the gut.

Journal Article Brain Res · August 15, 2018 Parkinson's disease (PD) is a debilitating neurodegenerative condition associated with tremor, rigidity, dementia, and gastrointestinal symptoms such as constipation, nausea and vomiting. The pathological hallmarks of PD are Lewy bodies and neurites in the ... Full text Link to item Cite

Interactions of Gut Endocrine Cells with Epithelium and Neurons.

Journal Article Compr Physiol · June 18, 2018 Even the simplest animals possess sophisticated systems for sensing and securing nutrients. After all, ensuring adequate nutrition is essential for sustaining life. Once multicellular animals grew too large to be nourished by simple diffusion of nutrients ... Full text Link to item Cite

Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis.

Journal Article Nat Commun · April 30, 2018 Merely touching the pancreas can lead to premature zymogen activation and pancreatitis but the mechanism is not completely understood. Here we demonstrate that pancreatic acinar cells express the mechanoreceptor Piezo1 and application of pressure within th ... Full text Link to item Cite

Regulation of Pancreatic Secretion

Chapter · January 1, 2018 Pancreatic secretion is regulated by highly integrated neural and hormonal influences that involve the brain, enteric nervous system, and gastrointestinal tract. Although these processes are complex they illustrate the finely regulated nature that is neede ... Full text Cite

Editorial introductions

Journal Article Current Opinion in Gastroenterology · September 1, 2017 Full text Cite

α-Synuclein in gut endocrine cells and its implications for Parkinson's disease.

Journal Article JCI Insight · June 15, 2017 Parkinson's disease (PD) is a progressive neurodegenerative disease with devastating clinical manifestations. In PD, neuronal death is associated with intracellular aggregates of the neuronal protein α-synuclein known as Lewy bodies. Although the cause of ... Full text Link to item Cite

Gastrointestinal hormones and the gut connectome.

Journal Article Curr Opin Endocrinol Diabetes Obes · February 2017 PURPOSE OF REVIEW: Provision of adequate nutrients by the gut is essential for survival and essential behaviors are linked to the proper ingestion and digestion of food. Recently, a new neural connection has been reported between sensory cells of the gut e ... Full text Link to item Cite

Location, Location, Location . . . It Is Important in Pancreatitis, Too.

Journal Article Cell Mol Gastroenterol Hepatol · January 2017 Full text Link to item Cite

Introduction: The progressive Dilemma in British politics

Journal Article Political Quarterly · January 1, 2017 This special edition reflects on the contemporary relevance of the insights and concerns of David Marquand’s book The Progressive Dilemma. In this Introduction, the editors set the scene for these reflections. They consider the structural changes that have ... Full text Cite

Some lessons of the SDP for labour’s present predicament

Journal Article Political Quarterly · January 1, 2017 Jeremy Corbyn’s election and re-election as Labour leader, together with the emergence of a new Conservative Prime Minister committed to Brexit, has led to renewed speculation about the possibility of a new party appealing to the ‘politically homeless’ in ... Full text Cite

From Pain to a Plan

Journal Article Political Quarterly · July 1, 2016 Full text Cite

Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain.

Journal Article Sci Rep · June 1, 2016 TRPV4 ion channels represent osmo-mechano-TRP channels with pleiotropic function and wide-spread expression. One of the critical functions of TRPV4 in this spectrum is its involvement in pain and inflammation. However, few small-molecule inhibitors of TRPV ... Full text Open Access Link to item Cite

128 A Gut-Brain Sensory Neuroepithelial Circuit

Conference Gastroenterology · April 2016 Full text Cite

Mechanism, assessment and management of pain in chronic pancreatitis: Recommendations of a multidisciplinary study group.

Journal Article Pancreatology · 2016 DESCRIPTION: Pain in patients with chronic pancreatitis (CP) remains the primary clinical complaint and source of poor quality of life. However, clear guidance on evaluation and treatment is lacking. METHODS: Pancreatic Pain working groups reviewed informa ... Full text Link to item Cite

Correlative Confocal and 3D Electron Microscopy of a Specific Sensory Cell.

Journal Article J Vis Exp · July 19, 2015 Delineation of a cell's ultrastructure is important for understanding its function. This can be a daunting project for rare cell types diffused throughout tissues made of diverse cell types, such as enteroendocrine cells of the intestinal epithelium. These ... Full text Link to item Cite

The gut connectome: making sense of what you eat.

Journal Article J Clin Invest · March 2, 2015 The enteric nervous system has been studied thus far as an isolated unit. As researchers probe deeper into the function of this system, it is evident that the neural network stretches beyond enteric neurons. It is formed by both intrinsic and extrinsic neu ... Full text Link to item Cite

Endogenous elevation of plasma cholecystokinin does not prevent gallstones.

Journal Article Eur J Clin Invest · March 2015 BACKGROUND: Regular gall bladder contraction reduces bile stasis and prevents gallstone formation. Intraduodenal administration of exogenous pancreatic secretory trypsin inhibitor-I (PSTI-I, also known as monitor peptide) causes cholecystokinin (CCK) secre ... Full text Link to item Cite

ILDR1 null mice, a model of human deafness DFNB42, show structural aberrations of tricellular tight junctions and degeneration of auditory hair cells.

Journal Article Hum Mol Genet · February 1, 2015 Featured Publication In the mammalian inner ear, bicellular and tricellular tight junctions (tTJs) seal the paracellular space between epithelial cells. Tricellulin and immunoglobulin-like (Ig-like) domain containing receptor 1 (ILDR1, also referred to as angulin-2) localize t ... Full text Link to item Cite

Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells.

Journal Article J Clin Invest · February 2015 Satiety and other core physiological functions are modulated by sensory signals arising from the surface of the gut. Luminal nutrients and bacteria stimulate epithelial biosensors called enteroendocrine cells. Despite being electrically excitable, enteroen ... Full text Open Access Link to item Cite

Acinar Cell Production of Leukotriene B4 Contributes to Development of Neurogenic Pancreatitis in Mice.

Journal Article Cell Mol Gastroenterol Hepatol · January 2015 BACKGROUND & AIMS: In the pancreas, activation of primary sensory nerves through the transient receptor potential ion channel TRPV1 contributes to the early stages of development of pancreatitis. Little is known about the mechanism by which this occurs. We ... Full text Link to item Cite

Labouring in the shadow of the british political tradition: The Dilemma of 'One Nation' politics in an age of disunification

Journal Article Political Quarterly · January 1, 2015 The British state is in flux and the Labour party is struggling to shape an effective response to the politics of disunification. This article reflects on the nature of Labour's governing project and its conception of modern statecraft which has evolved si ... Full text Cite

Recent advances in the regulation of pancreatic secretion.

Journal Article Curr Opin Gastroenterol · September 2014 PURPOSE OF REVIEW: This review highlights recent progress made in the field of pancreatic secretion. RECENT FINDINGS: This review summarizes a number of recent studies demonstrating the intracellular pathways by which hormones and neural inputs regulate pa ... Full text Link to item Cite

Ethanol contributes to neurogenic pancreatitis by activation of TRPV1.

Journal Article FASEB J · February 2014 Alcohol abuse is a major cause of pancreatitis in people, but the mechanism is unknown. It has been recently demonstrated that transient receptor potential vanilloid 1 (TRPV1) activation causes neurogenic inflammation and plays an important role in acute p ... Full text Link to item Cite

An enteroendocrine cell-enteric glia connection revealed by 3D electron microscopy.

Journal Article PLoS One · 2014 The enteroendocrine cell is the cornerstone of gastrointestinal chemosensation. In the intestine and colon, this cell is stimulated by nutrients, tastants that elicit the perception of flavor, and bacterial by-products; and in response, the cell secretes h ... Full text Open Access Link to item Cite

Modulation of taste responsiveness by the satiation hormone peptide YY.

Journal Article FASEB J · December 2013 It has been hypothesized that the peripheral taste system may be modulated in the context of an animal's metabolic state. One purported mechanism for this phenomenon is that circulating gastrointestinal peptides modulate the functioning of the peripheral g ... Full text Link to item Cite

Modulation of pancreatic exocrine and endocrine secretion.

Journal Article Curr Opin Gastroenterol · September 2013 PURPOSE OF REVIEW: Recent advances in the regulation of pancreatic secretion by secretagogues, modulatory proteins and neural pathways are discussed. RECENT FINDINGS: Downstream events involved in secretagogue stimulation of pancreatic secretion have been ... Full text Link to item Cite

Immunoglobulin-like domain containing receptor 1 mediates fat-stimulated cholecystokinin secretion.

Journal Article J Clin Invest · August 2013 Cholecystokinin (CCK) is a satiety hormone produced by discrete enteroendocrine cells scattered among absorptive cells of the small intestine. CCK is released into blood following a meal; however, the mechanisms inducing hormone secretion are largely unkno ... Full text Link to item Cite

CD36-dependent signaling mediates fatty acid-induced gut release of secretin and cholecystokinin.

Journal Article FASEB J · March 2013 Genetic variants in the fatty acid (FA) translocase FAT/CD36 associate with abnormal postprandial lipids and influence risk for the metabolic syndrome. CD36 is abundant on apical enterocyte membranes in the proximal small intestine, where it facilitates FA ... Full text Link to item Cite

Regulation of Pancreatic Secretion

Journal Article · December 1, 2012 Full text Cite

Pilot study of aprepitant for prevention of post-ERCP pancreatitis in high risk patients: a phase II randomized, double-blind placebo controlled trial.

Journal Article JOP · September 10, 2012 CONTEXT: Animal studies have demonstrated a role for substance P binding to neurokinin-1 receptor in the pathogenesis of acute pancreatitis. OBJECTIVE: Our aim was to assess the efficacy of a neurokinin-1 receptor antagonist (aprepitant) at preventing post ... Full text Link to item Cite

Neurohormonal regulation of pancreatic secretion.

Journal Article Curr Opin Gastroenterol · September 2012 PURPOSE OF REVIEW: Recent advances in the regulation of pancreatic secretion by neural and hormonal mechanisms are discussed in this review. RECENT FINDINGS: It has been shown that the multidrug-resistance protein MRP4 may play a role in the efflux of cAMP ... Full text Link to item Cite

Pancreatic secretory trypsin inhibitor I reduces the severity of chronic pancreatitis in mice overexpressing interleukin-1β in the pancreas.

Journal Article Am J Physiol Gastrointest Liver Physiol · March 1, 2012 IL-1β is believed to play a pathogenic role in the development of pancreatitis. Expression of human IL-1β in pancreatic acinar cells produces chronic pancreatitis, characterized by extensive intrapancreatic inflammation, atrophy, and fibrosis. To determine ... Full text Link to item Cite

Factors associated with survival of veterans with gastrointestinal neuroendocrine tumors.

Journal Article J Cancer Epidemiol · 2012 Background. Gastrointestinal (GI) neuroendocrine tumor (NET) incidence has been increasing; however, GI NET within the national Veterans Affairs (VA) health system has not been described. Methods. We used the VA Central Cancer Registry to identify the coho ... Full text Link to item Cite

Axon-like basal processes in enteroendocrine cells: characteristics and potential targets.

Journal Article Clin Transl Sci · October 2011 Enteroendocrine cells (EECs) play a key role in nutrient digestion and absorption, and are essential for normal life. Recently, EEC function has received considerable attention because several gastrointestinal hormones modulate insulin secretion and food i ... Full text Link to item Cite

Recent advances in pancreatic endocrine and exocrine secretion.

Journal Article Curr Opin Gastroenterol · September 2011 PURPOSE OF REVIEW: This review presents recent advancements in the mechanisms by which integrated signaling mechanisms elicit and regulate pancreatic endocrine and exocrine secretion. RECENT FINDINGS: Cholecystokinin (CCK) can stimulate exocrine secretion ... Full text Link to item Cite

Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats.

Journal Article Pancreas · July 2011 OBJECTIVES: We tested the hypothesis that leukotriene B4 (LTB4) mediates pancreatic inflammation in rats via activation of the transient receptor potential vanilloid 1 (TRPV1). METHODS: Leukotriene B4 or a vehicle was administered to adult rats via celiac ... Full text Link to item Cite

Amino acids stimulate cholecystokinin release through the Ca2+-sensing receptor.

Journal Article Am J Physiol Gastrointest Liver Physiol · April 2011 Cholecystokinin (CCK) is produced by discrete endocrine cells in the proximal small intestine and is released following the ingestion of food. CCK is the primary hormone responsible for gallbladder contraction and has potent effects on pancreatic secretion ... Full text Link to item Cite

Characterization of basal pseudopod-like processes in ileal and colonic PYY cells.

Journal Article J Mol Histol · February 2011 The peptide tyrosine tyrosine (PYY) is produced and secreted from L cells of the gastrointestinal mucosa. To study the anatomy and function of PYY-secreting L cells, we developed a transgenic PYY-green fluorescent protein mouse model. PYY-containing cells ... Full text Open Access Link to item Cite

Pancreatitis: the acid test.

Journal Article Gastroenterology · November 2010 Full text Link to item Cite

Pseudopod-like basal cell processes in intestinal cholecystokinin cells.

Journal Article Cell Tissue Res · August 2010 Cholecystokinin (CCK) is secreted by neuroendocrine cells comprising 0.1%-0.5% of the mucosal cells in the upper small intestine. Using CCK promoter-driven green fluorescent protein (GFP) expression in transgenic mice, we have applied immunofluorescence te ... Full text Link to item Cite

Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotype.

Journal Article Am J Physiol Gastrointest Liver Physiol · April 2010 Endogenous trypsin inhibitors are synthesized, stored, and secreted by pancreatic acinar cells. It is believed that they play a protective role in the pancreas by inhibiting trypsin within the cell should trypsinogen become prematurely activated. Rodent tr ... Full text Link to item Cite

Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor.

Journal Article Pancreas · January 2010 OBJECTIVES: Mutations in the gene encoding for pancreatic secretory trypsin inhibitor (PSTI) can contribute to chronic pancreatitis. In the current study, we tested whether overexpression of PSTI-I in mice protects against chronic pancreatitis and pancreat ... Full text Link to item Cite

A Tribute to Gary M. Green (1940-2008)

Journal Article Pancreas · October 2009 Full text Cite

Neural and hormonal regulation of pancreatic secretion.

Journal Article Curr Opin Gastroenterol · September 2009 PURPOSE OF REVIEW: The biology of the pancreas is exquisitely complex and involves both endocrine and exocrine functions that are regulated by an integrated array of neural and hormonal processes. This review discusses recent developments in the regulation ... Full text Link to item Cite

A pH-sensitive, neurogenic pathway mediates disease severity in a model of post-ERCP pancreatitis.

Journal Article Gut · November 2008 BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) has a high risk of pancreatitis although the underlying mechanisms are unclear. Transient receptor potential vanilloid 1 (TRPV1) is a cation channel expressed on C and Adelta fibres of prima ... Full text Link to item Cite

Pharmacologic disruption of TRPV1-expressing primary sensory neurons but not genetic deletion of TRPV1 protects mice against pancreatitis.

Journal Article Pancreas · May 2008 OBJECTIVES: Transient receptor potential subtype vanilloid 1 (TRPV1) is an ion channel that is primarily expressed by primary sensory neurons where it mediates pain and heat sensation and participates in neurogenic inflammation. In this study, we examined ... Full text Link to item Cite

Clinical features and physiological response to a test meal in purging disorder and bulimia nervosa.

Journal Article Arch Gen Psychiatry · September 2007 CONTEXT: Recent data suggest that purging disorder, a recently characterized form of eating disorder not otherwise specified, may be worthy of specific delineation in nosological schemes. However, more data are needed to determine how purging disorder diff ... Full text Link to item Cite

The role of Transient Receptor Potential Vanilloid 1 (TRPV1) channels in pancreatitis.

Journal Article Biochim Biophys Acta · August 2007 Premature activation of digestive enzymes within the pancreas which leads to autodigestion of the gland is an early step in the pathogenesis of pancreatitis. Pancreatic injury is followed by other manifestations of inflammation including plasma extravasati ... Full text Link to item Cite

Cholecystokinin.

Journal Article Curr Opin Endocrinol Diabetes Obes · February 2007 PURPOSE OF REVIEW: The hormone cholecystokinin was discovered in 1928 because of its ability to induce gallbladder contraction. Since then, cholecystokinin has been shown to possess multiple functions in the gastrointestinal tract and brain. This review di ... Full text Link to item Cite

Epigenetic silencing of genes in human colon cancer.

Journal Article Gastroenterology · September 2006 Full text Link to item Cite

Local disruption of the celiac ganglion inhibits substance P release and ameliorates caerulein-induced pancreatitis in rats.

Journal Article Am J Physiol Gastrointest Liver Physiol · July 2006 Primary sensory neurons of the C and Adelta subtypes express the vanilloid capsaicin receptor TRPV1 and contain proinflammatory peptides such as substance P (SP) that mediate neurogenic inflammation. Pancreatic injury stimulates these neurons causing the r ... Full text Link to item Cite

Pathophysiology of SPINK mutations in pancreatic development and disease.

Journal Article Endocrinol Metab Clin North Am · June 2006 The endogenous pancreatic trypsin inhibitor, SPINK, is believed to limit enzyme activity in the pancreas and reduce the risk of pancreatitis. Recently, mutations in the SPINK1 gene have been associated with development of both acute and chronic pancreatiti ... Full text Link to item Cite

Sequence variation outside the "active" region of dog and rabbit cholecystokinin-58 results in bioactivity differences.

Journal Article Pancreas · April 2006 OBJECTIVES: We propose that regions outside the bioactive 7-amino acid carboxyl terminus of cholecystokinin (CCK)-58 influence its biological activity. Here we evaluate if sequence variation of the N-terminal regions of rabbit and canine CCK-58 changes the ... Full text Link to item Cite

Lack of trophic pancreatic effects in humans with long-term administration of ximelagatran.

Journal Article Pancreas · March 2006 OBJECTIVES: Negative feedback regulation of pancreatic proteases controls pancreatic secretion in most species and pancreatic growth in rodents. Its mechanism involves the inhibition of intraluminal proteases, resulting in sustained elevation of plasma cho ... Full text Link to item Cite

Regulation of Pancreatic Secretion

Journal Article · January 1, 2006 Full text Cite

Not for the faint of heart.

Journal Article Gastroenterology · November 2005 Full text Link to item Cite

Neurohormonal control of exocrine pancreatic secretion.

Journal Article Curr Opin Gastroenterol · September 2005 PURPOSE OF REVIEW: Investigations into the neural and hormonal control of pancreatic exocrine function have led to many exciting discoveries over the past year. This review seeks to identify those articles that further our understanding into the complex re ... Full text Link to item Cite

Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice.

Journal Article Gastroenterology · March 2005 BACKGROUND & AIMS: Endogenous trypsin inhibitors are believed to inhibit protease activity if trypsin becomes inadvertently activated within the acinar cell. However, this action remains unproven, and the role of endogenous pancreatic trypsin inhibitors in ... Full text Link to item Cite

Inhibition of Clostridium difficile toxin A-induced colitis in rats by APAZA.

Journal Article Dig Dis Sci · March 2005 A new compound, APAZA, consisting of a molecule of 5-aminosalicylic acid linked to one molecule of 4-aminophenylacetic acid by an azo bond, was testedfor its ability to inhibit acute colitis in rats caused by Clostridium difficile toxin A. When administere ... Full text Link to item Cite

Susceptibility to pancreatitis related to PSTI/SPINK1 expression.

Journal Article Gastroenterol Clin North Am · December 2004 This article summarized several observations on the role of pancreatic secretory trypsin inhibitor in the pancreas. Although it long has been suspected that endogenous pancreatic trypsin inhibitors protect against inadvertent activation of trypsinogen, thi ... Full text Link to item Cite

Non-O1 Vibrio cholerae septicemia: case report, discussion of literature, and relevance to bioterrorism.

Journal Article Diagn Microbiol Infect Dis · August 2004 Non-O1 Vibrio cholerae (NOVC) is a rare cause of septicemia in the United States. We report a case of NOVC septicemia and discuss the literature pertaining to this organism. NOVC takes on new significance given that it can be confused with toxigenic V. cho ... Full text Link to item Cite

Identification of nonsulfated cholecystokinin-58 in canine intestinal extracts and its biological properties.

Journal Article Am J Physiol Gastrointest Liver Physiol · August 2004 Nonsulfated CCK(58) [CCK(58)(ns)] has not been considered to be of biological importance because CCK(58)(ns) binds poorly to the CCK(A) receptor and has only been identified once in intestinal extracts. In this work, a radioimmunoassay specific for the COO ... Full text Link to item Cite

Calcineurin mediates pancreatic growth in protease inhibitor-treated mice.

Journal Article Am J Physiol Gastrointest Liver Physiol · May 2004 CCK acts on pancreatic acinar cells to increase intracellular Ca(2+) leading to secretion of digestive enzymes and, in the long term, pancreatic growth. Calcineurin (CN) is a serine/threonine-specific protein phosphatase activated by Ca(2+) and calmodulin ... Full text Link to item Cite

Neurogenic inflammation and pancreatitis.

Journal Article Pancreatology · 2004 Stimulation of primary sensory neurons produces local vasodilation, plasma extravasation, and pain and is due largely to the release of the tachykinins substance P and calcitonin-gene-related peptide. Pathological activation of sensory neurons and the infl ... Full text Link to item Cite

Malcolm P. Tyor, MD, (1923-2003) AGA president 1981-1982

Journal Article GASTROENTEROLOGY · August 1, 2003 Link to item Cite

Elevated plasma cholecystokinin and appetitive ratings after consumption of a liquid meal in humans.

Journal Article Nutrition · June 2003 OBJECTIVE: This study had two objectives. The first was to evaluate the possibility that, in a previous study, a soup preload augmented the reduction of food intake in a test meal induced by an exogenous infusion of cholecystokinin (CCK) because the soup a ... Full text Link to item Cite

Cholecystokinin: Its role in health and disease

Journal Article Current Opinion in Endocrinology and Diabetes · February 1, 2003 Cholecystokinin is a classical gastrointestinal hormone secreted from endocrine cells of the small intestine on ingestion of a meal. It plays a major role in the coordination of many processes involved in the ingestion, digestion, and absorption of nutrien ... Full text Cite

Primary sensory neurons: a common final pathway for inflammation in experimental pancreatitis in rats.

Journal Article Am J Physiol Gastrointest Liver Physiol · October 2002 Featured Publication We hypothesized that neurogenic inflammation is a common final pathway for parenchymal inflammation in pancreatitis and evaluated the role of primary sensory neurons in secretagogue-induced and obstructive pancreatitis. Neonatal rats received either the pr ... Full text Link to item Cite

Neurohormonal control of pancreatic exocrine secretion.

Journal Article Curr Opin Gastroenterol · September 2002 The neurohormonal control of pancreatic exocrine secretion is a complex interaction of multiple pathways involving a large number of gut hormones, neurotransmitters, and neuropeptides. Recent studies have elucidated a role for cholecystokinin in the regula ... Full text Link to item Cite

The best and the brightest.

Journal Article Gastroenterology · April 2002 Full text Link to item Cite

Luminal CCK-releasing factor stimulates CCK release from human intestinal endocrine and STC-1 cells.

Journal Article Am J Physiol Gastrointest Liver Physiol · January 2002 Featured Publication CCK is secreted into the blood from intestinal endocrine cells following ingestion of a meal. Recently, it has been demonstrated that the ability of certain foods to stimulate CCK release is mediated by endogenously produced CCK-releasing factors. A newly ... Full text Link to item Cite

Capsaicin vanilloid receptor-1 mediates substance P release in experimental pancreatitis.

Journal Article Am J Physiol Gastrointest Liver Physiol · November 2001 Featured Publication We examined whether the capsaicin vanilloid receptor-1 (VR1) mediates substance P (SP) release from primary sensory neurons in experimental pancreatitis. Pancreatitis was achieved by 12 hourly injections of caerulein (50 microg/kg ip) in mice. One group re ... Full text Link to item Cite

Neurohumoral control of the exocrine pancreas.

Journal Article Curr Opin Gastroenterol · September 1999 Recent advances in the study of pancreatic exocrine secretion are reviewed, with an emphasis on neurohumoral mechanisms. In the past year, cDNA for the human pancreatic sodium-bicarbonate cotransporter was cloned, and the expressed protein was localized to ... Full text Link to item Cite

Activation of calcium channels by cAMP in STC-1 cells is dependent upon Ca2+ calmodulin-dependent protein kinase II.

Journal Article Biochem Biophys Res Commun · January 27, 1999 Activation of L-type calcium channels in the neuroendocrine, cholecytstokinin-secreting cell line, STC-1, is vital for secretion of CCK. In the present study, the regulation of L-type Ca2+ channels by cAMP and Ca2+ calmodulin dependent protein kinase II (C ... Full text Link to item Cite

Monitor peptide binding sites are expressed in the rat liver and small intestine.

Journal Article Peptides · 1999 125I-monitor peptide binding was performed using frozen sections of the rat liver and gut and visualized using autoradiography. Saturable binding was observed in unidentified single cells in the liver and in the mucosa of the small intestine. Epidermal gro ... Full text Link to item Cite

Inhibition of Na+/H+ exchange stimulates CCK secretion in STC-1 cells.

Journal Article Am J Physiol · October 1998 Featured Publication It has been demonstrated that K+ channel regulation of membrane potential is critical for control of CCK secretion. Because certain K+ channels are pH sensitive, it was postulated that pH affects K+ channel activity in the CCK-secreting cell line STC-1 and ... Full text Link to item Cite

Inhibition of Na+/H+ exchange stimulates CCK secretion in STC-1 cells

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY · October 1, 1998 Link to item Cite

Inhibition of gastric emptying in response to intestinal lipid is dependent on chylomicron formation.

Journal Article Am J Physiol Regul Integr Comp Physiol · June 1, 1998 Lipid in the intestine initiates feedback inhibition of proximal gastrointestinal function and food intake. In rats and humans, inhibition of gastric emptying is mediated, at least in part, by cholecystokinin (CCK)-A receptors, and in rats there is evidenc ... Full text Link to item Cite

On the measurement of cholecystokinin.

Journal Article Clin Chem · May 1998 Link to item Cite

Bioactivity of intraduodenally and intravenously infused fragments of luminal cholecystokinin releasing factor (LCRF).

Journal Article Regul Pept · February 27, 1998 A luminal cholecystokinin releasing factor (LCRF), has been purified from intestinal secretion and found to have a mass of 8136 daltons. The amino-terminal 41 residues have been sequenced. Previous studies showed that intraduodenal infusion of the syntheti ... Full text Link to item Cite

Salmeterol powder compared with albuterol aerosol as maintenance therapy for asthma in adolescent and adult patients.

Journal Article Clin Ther · 1998 Two multicenter, randomized, double-masked, placebo-controlled studies involving 451 adolescent and adult patients with mild-to-moderate asthma compared the efficacy and safety of salmeterol powder 50 micrograms twice daily with albuterol 180 micrograms fo ... Full text Link to item Cite

Distribution and localization of a novel cholecystokinin-releasing factor in the rat gastrointestinal tract.

Journal Article Endocrinology · December 1997 The purpose of this study was to examine the distribution and localization of an intestinal cholecystokinin (CCK)-releasing factor, called luminal CCK-releasing factor (LCRF), in the gastrointestinal tract and pancreas of the rat. RIA analysis indicates th ... Full text Link to item Cite

An amino-terminal fragment of LCRF, LCRF-(1-35), has the same activity as the natural peptide

Journal Article American Journal of Physiology · December 1, 1997 A cholecystoki nin (CCK)-releasing peptide, luminal CCK-releasing factor (LCRF), has been purified from rat jejunal secretion. Amino acid analysis and mass spectral analysis showed that the purified peptide is composed of 70-75 amino acid residues and has ... Cite

Regulation of biliary secretion through apical purinergic receptors in cultured rat cholangiocytes.

Journal Article Am J Physiol Gastrointest Liver Physiol · November 1, 1997 To evaluate whether ATP in bile serves as a signaling factor regulating ductular secretion, voltage-clamp studies were performed using a novel normal rat cholangiocyte (NRC) model. In the presence of amiloride (100 μM) to block Na+channels, exposure of the ... Full text Link to item Cite

An amino-terminal fragment of LCRF, LCRF-(1-35), has the same activity as the natural peptide.

Journal Article Am J Physiol · September 1997 A cholecystokinin (CCK)-releasing peptide, luminal CCK-releasing factor (LCRF), has been purified from rat jejunal secretion. Amino acid analysis and mass spectral analysis showed that the purified peptide is composed of 70-75 amino acid residues and has a ... Full text Link to item Cite

An amino-terminal fragment of LCRF, LCRF-(1-35), has the same activity as the natural peptide

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY · September 1, 1997 Link to item Cite

Postprandial cholecystokinin release and gastric emptying in patients with bulimia nervosa.

Journal Article Am J Clin Nutr · January 1997 This study was designed to investigate the biological underpinnings of the observed deficit in satiety in patients with bulimia nervosa. Eight women with bulimia nervosa and 10 age- and weight-matched control subjects consumed three laboratory meals consis ... Full text Link to item Cite

Cholecystokinin cells.

Journal Article Annu Rev Physiol · 1997 Featured Publication Cholecystokinin (CCK) is an important hormonal regulator of the digestive process. CCK cells are concentrated in the proximal small intestine, and hormone is secreted into the blood upon the ingestion of food. The physiological actions of CCK include stimu ... Full text Link to item Cite

Neurohumoral control of the exocrine pancreas

Journal Article Current Opinion in Gastroenterology · November 14, 1996 Recent advances in the study of pancreatic exocrine secretion are reviewed, with emphasis on neurohumoral mechanisms. Pancreatic exocrine and endocrine function are precisely regulated and involve both neural and hormonal mediators. The role of gut peptide ... Full text Cite

Regulation of cholecystokinin secretion in STC-1 cells by nitric oxide.

Journal Article Am J Physiol · October 1996 In the present study we evaluated the effects of agents anticipated to change NO levels on the secretion of cholecystokinin (CCK) from STC-1 cells. After a 15-min treatment with the nitric oxide (NO) generating agent sodium nitroprusside (SNP; 10 microM), ... Full text Link to item Cite

Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene.

Journal Article Nat Genet · October 1996 Hereditary pancreatitis (HP) is a rare, early-onset genetic disorder characterized by epigastric pain and often more serious complications. We now report that an Arg-His substitution at residue 117 of the cationic trypsinogen gene is associated with the HP ... Full text Link to item Cite

Regulation of cholecystokinin secretion in STC-1 cells by nitric oxide

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY · October 1, 1996 Link to item Cite

Evidence that CCK-58 has structure that influences its biological activity.

Journal Article Am J Physiol · May 1996 Many biologically active peptides exist in multiple molecular forms, but the functional significance of regions outside the region of bioactivity is unknown. The biological and immunological data presented in this study indicate that cholecystokinin-58 (CC ... Full text Link to item Cite

Evidence that CCK-58 has structure that influences its biological activity

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY · May 1, 1996 Link to item Cite

Purification and characterization of a luminal cholecystokinin-releasing factor from rat intestinal secretion.

Journal Article Proc Natl Acad Sci U S A · April 30, 1996 Featured Publication Cholecystokinin (CCK) secretion in rats and humans is inhibited by pancreatic proteases and bile acids in the intestine. It has been hypothesized that the inhibition of CCK release caused by pancreatic proteases is due to proteolytic inactivation of a CCK- ... Full text Link to item Cite

Beta-adrenergic regulation of cholecystokinin secretion in STC-1 cells.

Journal Article Am J Physiol · February 1996 Previously, it has been shown that an increase in adenosine 3',5'-cyclic monophosphate (cAMP) levels stimulates intestinal secretion of cholecystokinin (CCK); however, the mechanisms for increasing intracellular cAMP levels are not known. Using the CCK-sec ... Full text Link to item Cite

Depolarization-stimulated cholecystokinin secretion is mediated by L-type calcium channels in STC-1 cells.

Journal Article Am J Physiol · February 1996 To examine the role of calcium channels in depolarization-activated cholecystokinin (CCK) release, studies were performed in an intestinal CCK-secreting cell line, STC-1. Blockade of potassium channels with barium chloride (5 mM) increased the release of C ... Full text Link to item Cite

beta-Adrenergic regulation of cholecystokinin secretion in STC-1 cells

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY · February 1, 1996 Link to item Cite

Depolarization-stimulated cholecystokinin secretion is mediated by L-type calcium channels in STC-1 cells

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY · February 1, 1996 Link to item Cite

Adaptation to fat markedly increases pancreatic secretory response to intraduodenal fat in rats.

Journal Article Am J Physiol · January 1996 Exposure to higher levels of fat in the diet increases the secretion of fat-digesting enzymes in pancreatic juice. This study examines the functional consequences of this phenomenon and demonstrates that adapting rats to high fat (triglyceride) loads incre ... Full text Link to item Cite

Adaptation to fat markedly increases pancreatic secretory response to intraduodenal fat in rats

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY · January 1, 1996 Link to item Cite

Chemical messengers of the gut.

Journal Article West J Med · November 1995 Link to item Cite

Regulation of cholecystokinin secretion by intraluminal releasing factors.

Journal Article Am J Physiol · September 1995 Featured Publication Ingested nutrients stimulate secretion of gastrointestinal hormones that are necessary for the coordinated processes of digestion and absorption of food. One of the most important hormonal regulators of the digestive process is cholecystokinin (CCK). This ... Full text Link to item Cite

REGULATION OF CHOLECYSTOKININ SECRETION BY INTRALUMINAL RELEASING FACTORS

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY · September 1, 1995 Link to item Cite

Dietary regulation of glucose-dependent insulinotropic peptide (GIP) gene expression in rat small intestine.

Journal Article Comp Biochem Physiol C Pharmacol Toxicol Endocrinol · February 1995 The hormone, glucose-dependent insulinotropic peptide (GIP), is an important incretin regulator of the gastrointestinal tract. To investigate whether diet is important for the control of GIP gene expression in the small intestine, GIP messenger RNA (mRNA) ... Full text Link to item Cite

Phenylalanine-stimulated secretion of cholecystokinin is calcium dependent.

Journal Article Am J Physiol · January 1995 The secretion of cholecystokinin was examined in STC-1 cells, an intestinal cholecystokinin (CCK)-secreting cell line. Exposure to the amino acid L-phenylalanine increased release of CCK by 135%, 180%, and 251% of control levels after 15-min treatments wit ... Full text Link to item Cite

PHENYLALANINE-STIMULATED SECRETION OF CHOLECYSTOKININ IS CALCIUM-DEPENDENT

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY · January 1, 1995 Link to item Cite

Regulation of cholecystokinin secretion by ATP-sensitive potassium channels

Journal Article American Journal of Physiology - Gastrointestinal and Liver Physiology · November 9, 1994 The relationship of potassium channel activity to the secretion of cholecystokinin (CCK) was evaluated in STC-I cells, an intestinal CCK- secreting cell line. Patch-clamp and 86Rb efflux studies showed that an ATP-sensitive potassium channel was endogenous ... Cite

Regulation of cholecystokinin secretion by bombesin in STC-1 cells.

Journal Article Am J Physiol · November 1994 Bombesin stimulates cholecystokinin (CCK) secretion, presumably by a direct effect on the intestinal CCK cell. The present objectives were to characterize bombesin-stimulated CCK release and to investigate the role of calcium in CCK secretion in an intesti ... Full text Link to item Cite

REGULATION OF CHOLECYSTOKININ SECRETION BY BOMBESIN IN STC-1 CELLS

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY · November 1, 1994 Link to item Cite

Characterization of ATP-sensitive potassium channels in intestinal, cholecystokinin-secreting cells.

Journal Article Biochem Biophys Res Commun · October 28, 1994 In the present study, the electrophysiologic properties of ATP-sensitive potassium channels were evaluated in an intestinal, cholecystokinin-secreting cell line (STC-1). Channels were operative under basal conditions and, in cell-attached membrane patches, ... Full text Link to item Cite

Regulation of cholecystokinin secretion by ATP-sensitive potassium channels.

Journal Article Am J Physiol · October 1994 The relationship of potassium channel activity to the secretion of cholecystokinin (CCK) was evaluated in STC-1 cells, an intestinal CCK-secreting cell line. Patch-clamp and 86Rb efflux studies showed that an ATP-sensitive potassium channel was endogenousl ... Full text Link to item Cite

REGULATION OF CHOLECYSTOKININ SECRETION BY ATP-SENSITIVE POTASSIUM CHANNELS

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY · October 1, 1994 Link to item Cite

Regulation of cholecystokinin synthesis and secretion in rat intestine.

Journal Article J Nutr · August 1994 Cholecystokinin is a classical gastrointestinal hormone that is produced by discrete endocrine cells of the upper small intestine. Cholecystokinin is produced in various molecular forms that result from differences in posttranslation processing of a single ... Full text Link to item Cite

Regulation of cholecystokinin secretion by calcium-dependent calmodulin kinase II: differential effects of phenylalanine and cAMP.

Journal Article Biochem Biophys Res Commun · June 30, 1994 The release of cholecystokinin was investigated in STC-1 cells, an intestinal cholecystokinin-secreting cell line. Fifteen minute incubation of cells with the amino acid, L-phenylalanine (20 mM), or the phosphodiesterase inhibitor, IBMX (100 microM), stimu ... Full text Link to item Cite

Developmental expression of the glucose-dependent insulinotropic polypeptide gene in rat intestine.

Journal Article Biochem Biophys Res Commun · June 15, 1994 The developmental expression of the glucose-dependent insulinotropic polypeptide (GIP) gene was investigated in rat intestine. Steady state levels of GIP mRNA were determined in the intestine during fetal and postnatal development by double ribonuclease pr ... Full text Link to item Cite

REGULATION OF CCK SECRETION BY POTASSIUM CHANNELS

Conference GASTROENTEROLOGY · April 1, 1994 Link to item Cite

Natural and synthetic CCK-58. Novel reagents for studying cholecystokinin physiology.

Journal Article Ann N Y Acad Sci · March 23, 1994 CCK-58 is a unique reagent for testing how segments of a peptide far removed from its active site can influence the expression of its biological activity. Indications of tertiary structure have come from studies with natural peptide purified from canine sm ... Full text Link to item Cite

Inhibitors of ATP-sensitive potassium channels stimulate intestinal cholecystokinin secretion.

Journal Article Peptides · 1994 Recently, a role for adenosine 5'-triphosphate(ATP)-sensitive potassium channels in the regulation of cholecystokinin (CCK) secretion has been described in STC-1 cells, an intestinal CCK-secreting cell line. To examine whether a similar mechanism might par ... Full text Link to item Cite

Regulation of cholecystokinin secretion by bombesin in STC-1 cells

Journal Article AM.J.PHYSIOL. · January 1, 1994 Cite

Total synthesis, purification, and characterization of human [Phe(p-CH2SO 3Na)52, Nle32,53,56, Nal55]-CCK20-58, [Tyr52, Nle32,53,56, Nal55]-CCK-58, and [Phe(p-CH2SO3Na)52, Nle32,53,56, Nal55]-CCK-58.

Journal Article J Protein Chem · October 1993 The synthesis of [Phe(p-CH2SO3Na)52, Nle32,53,56 Nal55]-CCK20-58, [Tyr52, Nle32,53,56, Nal55]-CCK-58 and of [Phe(p-CH2SO3Na)52, Nle32,53,56, Nal55]-CCK-58 using the (9-fluorenylmethyloxy)-carbonyl (Fmoc) strategy on a 2,4-DMBHA resin is described. The crud ... Full text Link to item Cite

Potassium channels regulate cholecystokinin secretion in STC-1 cells.

Journal Article Biochem Biophys Res Commun · September 30, 1993 Following blockade of plasma membrane potassium channels with barium or tetraethylammonium chloride, release of cholecystokinin was increased in an intestinal cell line (STC-1). Treatment with calcium channel blockers inhibited barium- or TEA-induced secre ... Full text Link to item Cite

Evidence for indirect dietary regulation of cholecystokinin release in rats.

Journal Article Am J Physiol · July 1993 Food ingestion stimulates cholecystokinin (CCK) release from the proximal intestine, but the mechanisms involved are not well understood. To investigate this effect in vivo in intact rats, plasma CCK was measured after orogastric feeding of proteins, prote ... Full text Link to item Cite

EVIDENCE FOR INDIRECT DIETARY-REGULATION OF CHOLECYSTOKININ RELEASE IN RATS

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY · July 1, 1993 Link to item Cite

Synthesis of human CCK26-33 and CCK-33 related analogues on 2,4-DMBHA and TMBHA.

Journal Article J Med Chem · June 11, 1993 New analogues of human cholecystokinin in which the Tyr(SO3H) has been replaced by Phe(p-CH2SO3Na), methionines by norleucines, and tryptophan by 2-naphthylalanine([Phe(p-CH2- SO3Na)27,Nle28,31,Nal30]-CCK26-33 and [Phe(p-CH2SO3Na)27,Nle7,28,31,Nal30]-CCK-3 ... Full text Link to item Cite

Calcium-dependent regulation of cholecystokinin secretion and potassium currents in STC-1 cells.

Journal Article Am J Physiol · June 1993 Secretory and electrophysiological properties of STC-1 cells, a cholecystokinin-secreting cell line, were examined with a radioimmunoassay and patch-clamp recording techniques. Stimulation of cholecystokinin secretion was seen after exposure to agents anti ... Full text Link to item Cite

Isolation and characterization of the gene encoding rat glucose-dependent insulinotropic peptide.

Journal Article Biochem Biophys Res Commun · May 28, 1993 The rat glucose-dependent insulinotropic peptide (GIP) gene has been isolated and characterized. The gene spans approximately 8.2 kilobase pairs (kb) and the GIP mRNA (0.8 kb) is encoded by six exons. The 42 amino acid hormone is encoded by exons 3 and 4. ... Full text Link to item Cite

Reduced postprandial cholecystokinin (CCK) secretion in patients with noninsulin-dependent diabetes mellitus: evidence for a role for CCK in regulating postprandial hyperglycemia.

Journal Article J Clin Endocrinol Metab · February 1993 The plasma cholecystokinin (CCK) response to a test meal was studied in 16 control subjects and 15 patients with noninsulin-dependent diabetes mellitus (NIDDM). Basal CCK levels were approximately 1 pmol in both groups. However, after the test meal, plasma ... Full text Link to item Cite

Intraventricular CCK-8 reduces single meal size in the baboon by interaction with type-A CCK receptors.

Journal Article Am J Physiol · October 1992 Intraventricular cholecystokinin COOH-terminal octapeptide (CCK-8) decreases meal size in the meal-trained baboon. In the present study, we tested whether this action is mediated by CCK-A receptors, CCK-B receptors, or both. Intraventricular administration ... Full text Link to item Cite

Molecular cloning of rat glucose-dependent insulinotropic peptide (GIP).

Journal Article Biochim Biophys Acta · August 17, 1992 A cDNA clone encoding glucose-dependent insulinotropic peptide (GIP) was identified that consisted of 34 bp of 5' untranslated sequence, an open reading frame of 432 bp and 115 bp in the 3' untranslated region. The deduced amino acid sequence revealed a 14 ... Full text Link to item Cite

Regulation of appetite and cholecystokinin secretion in anorexia nervosa.

Journal Article Am J Psychiatry · July 1992 Six patients with anorexia nervosa, the same patients after weight normalization, and six healthy control subjects had similar fasting and postprandial plasma cholecystokinin concentrations. These data do not support the hypothesis that low levels of hunge ... Full text Link to item Cite

Cholecystokinin cells purified by fluorescence-activated cell sorting respond to monitor peptide with an increase in intracellular calcium.

Journal Article Proc Natl Acad Sci U S A · June 1, 1992 Cholecystokinin (CCK) is secreted from specific enteroendocrine cells of the upper small intestine upon ingestion of a meal. In addition to nutrients, endogenously produced factors appear to act within the gut lumen to stimulate CCK release. One such facto ... Full text Link to item Cite

Role of calcium in monitor peptide-stimulated cholecystokinin release from perifused intestinal cells.

Journal Article Am J Physiol · May 1992 Monitor peptide stimulates cholecystokinin (CCK) release from the intestine, but the cellular mechanisms responsible for this effect are uncertain. In the present study, the roles of membrane potential difference and calcium influx in monitor peptide-media ... Full text Link to item Cite

Characterization of canine intestinal cholecystokinin-58 lacking its carboxyl-terminal nonapeptide. Evidence for similar post-translational processing in brain and gut.

Journal Article J Biol Chem · July 25, 1991 An antibody raised against a synthetic cholecystokinin (CCK) analog, (1-27)-(CCK)-33, corresponding to the midregion of CCK-58, detected immunoreactivity in intestinal extracts which eluted between the positions of CCK-33/39 and CCK-58 on high performance ... Link to item Cite

Regulation of intestinal cholecystokinin and somatostatin mRNA by bombesin in rats.

Journal Article Am J Physiol · July 1991 The neuropeptide bombesin has been shown to stimulate secretion of several gastrointestinal hormones, including cholecystokinin (CCK). We have previously demonstrated that stimulation of CCK release by feeding is associated with an increase in steady-state ... Full text Link to item Cite

Influence of food deprivation on intestinal cholecystokinin and somatostatin.

Journal Article Gastroenterology · April 1991 Dietary stimulation has trophic effects on the gastrointestinal tract, whereas prolonged fasting causes mucosal atrophy. Whether gastrointestinal endocrine cells within the mucosa are similarly affected is unknown. The present study was designed to determi ... Full text Link to item Cite

CCK-releasing activity of rat intestinal secretion: effect of atropine and comparison with monitor peptide.

Journal Article Pancreas · November 1990 A bioassay for studying the cholecystokinin (CCK)-releasing activity of intraluminal protease-sensitive bioactive peptides was developed. In conscious rats, bile and pancreatic juice were chronically diverted from the proximal intestine to the ileum to cau ... Full text Link to item Cite

Regulation of plasma cholecystokinin levels by bile and bile acids in the rat.

Journal Article Gastroenterology · September 1990 To determine whether intraduodenal bile acids inhibit pancreatic secretion and cholecystokinin (CCK) release independent of pancreatic proteases, experiments were conducted in rats with bile and pancreatic juice chronically diverted to the ileum. Diversion ... Full text Link to item Cite

Atropine enhances food-stimulated CCK secretion in the rat.

Journal Article Pancreas · September 1990 The effect of atropine on plasma cholecystokinin (CCK) and pancreatic secretion during intraintestinal infusion of a conventional defined formula liquid diet (Ensure HN, Ross Laboratories, 1.06 kcal/ml) was studied in conscious rats. Rats were prepared wit ... Full text Link to item Cite

Cholecystokinin is not a major hormonal regulator of lower esophageal sphincter pressure.

Journal Article Gastroenterology · September 1990 Although injection of cholecystokinin can reduce resting lower esophageal sphincter pressure, the physiological significance of this finding has not been established. The purpose of this double-blind crossover study was to determine the effect of physiolog ... Full text Link to item Cite

Regulation of pancreatic endocrine function by cholecystokinin: studies with MK-329, a nonpeptide cholecystokinin receptor antagonist.

Journal Article J Clin Endocrinol Metab · May 1990 A cholecystokinin (CCK) receptor antagonist, MK-329, was used to explore the physiological role of CCK in regulating pancreatic endocrine function in humans. The ability of CCK to increase plasma pancreatic polypeptide (PP) concentrations and blockade of t ... Full text Link to item Cite

Cholecystokinin does not stimulate prosomatostatin-derived peptides in man.

Journal Article J Clin Endocrinol Metab · May 1990 In man, plasma cholecystokinin (CCK) and somatostatin-28 (S-28) levels increase after ingestion of a mixed meal. Both peptides originate from the gastrointestinal tract. In supra- and periphysiological doses, CCK stimulates the release of somatostatin-14 f ... Full text Link to item Cite

DIETARY-REGULATION OF PANCREATIC HORMONE GENE-EXPRESSION

Journal Article CLINICAL RESEARCH · April 1, 1990 Link to item Cite

Somatostatin regulates duodenal cholecystokinin and somatostatin messenger RNA.

Journal Article Am J Physiol · March 1990 The gastrointestinal peptides, cholecystokinin (CCK) and somatostatin, are produced by discrete endocrine cells in the mucosa of the small intestine. Although somatostatin may inhibit CCK secretion, the mechanism by which this occurs is unknown. The presen ... Full text Link to item Cite

SOMATOSTATIN REGULATES DUODENAL CHOLECYSTOKININ AND SOMATOSTATIN MESSENGER-RNA

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY · March 1, 1990 Link to item Cite

Lack of cholinergic control in feedback regulation of pancreatic secretion in the rat.

Journal Article Gastroenterology · February 1990 The effect of atropine (100 micrograms/kg/h, i.v.) on plasma cholecystokinin and pancreatic secretion during diversion of bile and pancreatic juice from the intestine was studied in 8 conscious rats equipped with jugular vein, pancreatic, biliary, and duod ... Full text Link to item Cite

Somatostatin regulates duodenal cholecystokinin and somatostatin messenger RNA

Journal Article American Journal of Physiology Gastrointestinal and Liver Physiology · January 1, 1990 The gastrointestinal peptides, cholecystokinin (CCK) and somatostatin, are produced by discrete endocrine cells in the mucosa of the small intestine. Although somatostatin may inhibit CCK secretion, the mechanism by which this occurs is unknown. The presen ... Cite

Integrated actions of cholecystokinin on the gastrointestinal tract: use of the cholecystokinin bioassay.

Journal Article Gastroenterol Clin North Am · December 1989 This article has centered on the hormonal actions of CCK on a variety of different target tissues. Until the development of specific assays for measuring plasma levels of the hormone, it was not possible to distinguish physiologic from pharmacologic effect ... Link to item Cite

Endogenous cholecystokinin does not decrease food intake or gastric emptying in fasted rats.

Journal Article Am J Physiol · December 1989 To investigate the hypothesized inhibitory effect of cholecystokinin (CCK) released from the small intestine on food intake and gastric emptying, we infused soybean trypsin inhibitor (STI) into the stomach or duodenum of male rats deprived of food for 17 h ... Full text Link to item Cite

Endogenous cholecystokinin does not decrease food intake or gastric emptying in fasted rats

Journal Article American Journal of Physiology Regulatory Integrative and Comparative Physiology · December 1, 1989 To investigate the hypothesized inhibitory effect of cholecystokinin (CCK) released from the small intestine on food intake and gastric emptying, we infused soybean trypsin inhibitor (STI) into the stomach or duodenum of male rats deprived of food for 17 h ... Cite

Effects of a novel cholecystokinin (CCK) receptor antagonist, MK-329, on gallbladder contraction and gastric emptying in humans. Implications for the physiology of CCK.

Journal Article J Clin Invest · October 1989 To explore the physiology of cholecystokinin (CCK) in humans, we investigated the effect on gallbladder contraction and gastric emptying of a recently developed CCK receptor antagonist, MK-329. In a double-blind, four-period crossover study eight subjects ... Full text Link to item Cite

Gallstone formation during weight-reduction dieting.

Journal Article Arch Intern Med · August 1989 We investigated the development of gallstones over an 8-week period from the onset of dieting in 51 obese men and women and 26 nondieting control subjects. Gallbladder examinations were performed by abdominal real-time ultrasonography for the detection of ... Link to item Cite

Feedback regulation by trypsin: evidence for intraluminal CCK-releasing peptide.

Journal Article Am J Physiol · August 1989 The mechanism by which intraluminal proteases inhibit pancreatic secretion and CCK release was investigated in conscious rats. We hypothesized that the stimulation of pancreatic secretion and CCK release that occurs in the absence of luminal trypsin is cau ... Full text Link to item Cite

Plasma secretin, CCK, and pancreatic secretion in response to dietary fat in the rat.

Journal Article Am J Physiol · June 1989 The role of fat in regulation of pancreatic secretion was studied in conscious rats by measuring pancreatic secretion and plasma cholecystokinin (CCK) and secretin responses to intraluminal infusion of fat, protein, or trypsin inhibitor via the duodenum. I ... Full text Link to item Cite

Intraventricular CCK inhibits food intake and gastric emptying in baboons.

Journal Article Am J Physiol · June 1989 To evaluate the role of cholecystokinin (CCK) as a physiological regulator of meal size and gastric emptying in the baboon, we measured plasma CCK bioactivity during 30-min meals alone and after intravenous or intraventricular infusions of CCK COOH-termina ... Full text Link to item Cite

Inhibitory regulation of rat exocrine pancreas by peptide YY and pancreatic polypeptide.

Journal Article Am J Physiol · April 1989 Peptide YY (PYY) and pancreatic polypeptide (PP) have been shown to inhibit exocrine pancreatic secretion in vivo in a variety of species. This study evaluates the type of stimulation inhibited by PYY and PP by examining, in urethan-anesthetized rats, the ... Full text Link to item Cite

Pancreatic digestive enzyme gene expression: effects of CCK and soybean trypsin inhibitor.

Journal Article Am J Physiol · April 1989 Regulation of pancreatic gene expression by cholecystokinin (CCK) was examined in the rat using cloned cDNA probes to quantify changes in specific mRNAs (amylase, trypsinogen I, chymotrypsinogen B, and ribonuclease). Rats were administered intraduodenally ... Full text Link to item Cite

Bulimia nervosa.

Journal Article N Engl J Med · March 16, 1989 Full text Link to item Cite

BULIMIA NERVOSA - REPLY

Journal Article NEW ENGLAND JOURNAL OF MEDICINE · March 16, 1989 Link to item Cite

Meal-related cholecystokinin secretion in eating and affective disorders.

Journal Article Psychopharmacol Bull · 1989 The satiety-inducing effects of centrally and peripherally administered cholecystokinin (CCK) in experimental animals have been well documented. Recently, studies in humans showed that CCK is released into plasma following food ingestion, a phenomenon post ... Link to item Cite

Inhibitory regulation of rat exocrine pancreas by peptide YY and pancreatic polypeptide

Journal Article American Journal of Physiology Gastrointestinal and Liver Physiology · January 1, 1989 Peptide YY (PYY) and pancreatic polypeptide (PP) have been shown to inhibit exocrine pancreatic secretion in vivo in a variety of species. This study evaluates the type of stimulation inhibited by PYY and PP by examining, in urethan-anesthetized rats, the ... Cite

Pancreatic digestive enzyme gene expression: Effects of CCK and soybean trypsin inhibitor

Journal Article American Journal of Physiology Gastrointestinal and Liver Physiology · January 1, 1989 Regulation of pancreatic gene expression by cholecystokinin (CCK) was examined in the rat using cloned cDNA probes to quantify changes in specific mRNAs (amylase, trypsinogen I, chymotrypsinogen B, and ribonuclease). Rats were administered intraduodenally ... Cite

Feedback regulation by trypsin: Evidence for intraluminal CCK-releasing peptide

Journal Article American Journal of Physiology Gastrointestinal and Liver Physiology · January 1, 1989 The mechanism by which intraluminal proteases inhibit pancreatic secretion and CCK release was investigated in conscious rats. We hypothesized that the stimulation of pancreatic secretion and CCK release that occurs in the absence of luminal trypsin is cau ... Cite

Intraventricular CCK inhibits food intake and gastric emptying in baboons

Journal Article American Journal of Physiology Regulatory Integrative and Comparative Physiology · January 1, 1989 To evaluate the role of cholecystokinin (CCK) as a physiological regulator of meal size and gastric emptying in the baboon, we measured plasma CCK bioactivity during 30-min meals alone and after intravenous or intraventricular infusions of CCK COOH-termina ... Cite

Plasma secretin, CCK, and pancreatic secretion in response to dietary fat in the rat

Journal Article American Journal of Physiology Gastrointestinal and Liver Physiology · January 1, 1989 The role of fat in regulation of pancreatic secretion was studied in conscious rats by measuring pancreatic secretion and plasma cholecystokinin (CCK) and secretin responses to intraluminal infusion of fat, protein, or trypsin inhibitor via the duodenum. I ... Cite

Effects of cholecystokinin on pancreatic ornithine decarboxylase gene expression.

Journal Article Am J Physiol · December 1988 The effects of cholecystokinin (CCK) on pancreatic ornithine decarboxylase (ODC) gene expression were studied in the rat. Plasma CCK concentrations were raised to levels comparable to postprandial values either by intravenous infusion of CCK octapeptide (C ... Full text Link to item Cite

Effects of cholecystokinin on pancreatic ornithine decarboxylase gene expression

Journal Article American Journal of Physiology Gastrointestinal and Liver Physiology · December 1, 1988 The effects of cholecystokinin (CCK) on pancreatic ornithine decarboxylase (ODC) gene expression were studied in the rat. Plasma CCK concentrations were raised to levels comparable to postprandial values either by intravenous infusion of CCK octapeptide (C ... Cite

Impaired cholecystokinin secretion in bulimia nervosa.

Journal Article N Engl J Med · September 15, 1988 Bulimia nervosa is a prevalent disorder of unknown cause, characterized by recurrent episodes of uncontrollable eating. In the light of recent evidence that the gastrointestinal hormone cholecystokinin induces satiety and reduces food intake in laboratory ... Full text Link to item Cite

Dietary regulation of rat intestinal cholecystokinin gene expression.

Journal Article J Clin Invest · June 1988 Cholecystokinin (CCK) is a gastrointestinal hormone produced by discrete endocrine cells in the upper small intestine and released after ingestion of a meal. The present study was designed to determine if enhanced CCK secretion is associated with increases ... Full text Link to item Cite

Physiological role for cholecystokinin in reducing postprandial hyperglycemia in humans.

Journal Article J Clin Invest · June 1988 It is known that the ingestion of glucose alone causes a greater increase in plasma glucose levels than ingestion of the same amount of glucose given with other nutrients. Since physiological plasma concentrations of cholecystokinin (CCK) prolong gastric e ... Full text Link to item Cite

Physiological concentrations of cholecystokinin stimulate amino acid-induced insulin release in humans.

Journal Article J Clin Endocrinol Metab · September 1987 After a meal, hormones released from the gut potentiate insulin release. This study was undertaken to determine if physiological concentrations of plasma cholecystokinin (CCK) stimulate insulin secretion in man. Employing a specific CCK bioassay, postprand ... Full text Link to item Cite

Jejunal bypass stimulation of pancreatic growth and cholecystokinin secretion in rats: importance of luminal nutrients.

Journal Article Gut · 1987 The effect of jejunal bypass on pancreatic growth and plasma cholecystokinin (CCK) was investigated in rats. Rats underwent bypass of jejunum or sham operation. Rats with jejunal bypass were further divided into three groups; one group received a continuou ... Full text Link to item Cite

Pancreatic growth: interaction of exogenous cholecystokinin, a protease inhibitor, and a cholecystokinin receptor antagonist in mice.

Journal Article Gut · 1987 The effects on pancreatic growth and plasma CCK concentration of chronic feeding of camostate (400 mg/kg day for 10 days), a potent inhibitor of serine proteases including trypsin, were assessed in the mouse. For comparison, the trophic effects of chronic ... Full text Link to item Cite

Beneficial effects of cholecystokinin-receptor blockade and inhibition of proteolytic enzyme activity in experimental acute hemorrhagic pancreatitis in mice. Evidence for cholecystokinin as a major factor in the development of acute pancreatitis.

Journal Article J Clin Invest · October 1986 The effects of the cholecystokinin (CCK)-receptor antagonist proglumide, the protease inhibitor gabexate, and the hormones secretin and cholecystokinin-octapeptide (CCK-8) were studied in a model of acute hemorrhagic pancreatitis induced by feeding mice a ... Full text Link to item Cite

Proteins but not amino acids, carbohydrates, or fats stimulate cholecystokinin secretion in the rat.

Journal Article Am J Physiol · August 1986 Because of prior difficulties in measuring plasma cholecystokinin (CCK) levels, it has not been established which components of food stimulate CCK secretion in rats. In the present study, we used a sensitive and specific bioassay for measuring plasma CCK a ... Full text Link to item Cite

Plasma cholecystokinin and pancreatic growth during adaptation to dietary protein.

Journal Article Am J Physiol · July 1986 The relationship among plasma cholecystokinin (CCK), pancreatic growth, and food intake was studied in rats over a 2-wk period of adaptation from a very low-protein to a very high-protein diet. Rats adapted to a control diet (5% casein) were killed at 0900 ... Full text Link to item Cite

Regulation of gastric emptying in humans by cholecystokinin.

Journal Article J Clin Invest · March 1986 In the present study we used a bioassay system for measuring plasma cholecystokinin (CCK) to evaluate whether CCK has a physiologic role in regulating gastric emptying in humans. Plasma CCK levels and gastric emptying after ingestion of a mixed liquid meal ... Full text Link to item Cite

Relative bioactivities of cholecystokinins-8 and -33 on rat pancreatic acini.

Journal Article Peptides · 1986 The relative potencies of cholecystokinin (CCK-33) and its carboxyl terminal octapeptide (CCK-8) for stimulation of amylase release from rat pancreatic acini was measured. Porcine CCK-33 and synthetic CCK-8 were initially subjected to high pressure liquid ... Full text Link to item Cite

Cholecystokinin bioactivity in human plasma. Molecular forms, responses to feeding, and relationship to gallbladder contraction.

Journal Article J Clin Invest · April 1985 A sensitive and specific bioassay for the measurement of cholecystokinin (CCK) in human plasma was developed to determine the molecular forms of CCK in circulation, CCK responses to feeding, and the physiologic role of CCK in gallbladder contraction. First ... Full text Link to item Cite

Bioassay of plasma cholecystokinin in rats: effects of food, trypsin inhibitor, and alcohol.

Journal Article Gastroenterology · September 1984 We report herein a specific, sensitive, and rapid bioassay for measuring plasma cholecystokinin in rats. Plasma was first passed through octadecylsilylsilica cartridges and the extracts were then tested for their content of cholecystokinin, based on their ... Link to item Cite

Renal uptake of lutropin. Studies based on electron microscopic autoradiography and nephrectomy.

Journal Article Mol Cell Biochem · March 21, 1977 Nephrectomy of mature rats was found to result in a significant increase in the circulatory half-life of tritiated ovine lutropin. The interaction of the glycoprotein hormone with the kidneys was studied in a more direct fashion using electron microscopic ... Full text Link to item Cite

Renal and hepatic lysosomal catabolism of luteinizing hormone.

Journal Article Mol Cell Endocrinol · May 1976 Following an intravenous injection of tritiated ovine lutenizing hormone (LH) into mature male rats, the liver and kidneys accumulate a significant portion of the non-excreted hormone. The subcellular distribution of total radioactivity in both tissues was ... Full text Link to item Cite

The metabolism of luteinizing hormone. Plasma clearance, urinary excretion, and tissue uptake.

Journal Article Mol Cell Endocrinol · July 1975 The kinetics of plasma clearance, tissue uptake, and urinary excretion of tritiated ovine pituitary luteinizing hormone in adult male rats are reported. Most of the intravenously injected tritiated gonadotropin is cleared from circulation with a half-life ... Full text Link to item Cite