Scholars@Duke
David Carl Steffens

David Carl Steffens

Professor Emeritus of Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology
steff001@mc.duke.edu
Box 3903 Med Ctr, Durham, NC 27710
3547 Hosp South, Durham, NC 27710

Selected Publications

The Role of State Versus Trait Anxiety on Cognition in Older Adults With Major Depressive Disorder.

Journal Article Am J Geriatr Psychiatry · September 2024 OBJECTIVE: Anxiety superimposed on late life depression (LLD) results in greater changes to prefrontal and medial temporal brain regions compared to depression alone. Yet, the combined impact of anxiety and depression on cognition in LLD has not been thoro ... Full text Link to item Cite

Hybrid representation learning for cognitive diagnosis in late-life depression over 5 years with structural MRI.

Journal Article Med Image Anal · May 2024 Late-life depression (LLD) is a highly prevalent mood disorder occurring in older adults and is frequently accompanied by cognitive impairment (CI). Studies have shown that LLD may increase the risk of Alzheimer's disease (AD). However, the heterogeneity o ... Full text Link to item Cite

Treatment-Resistant Depression in Older Adults.

Journal Article N Engl J Med · February 15, 2024 A 67-year-old woman with a history of obesity, chronic low back pain, and recurrent episodes of major depression presents with mild depressive symptoms of more than 2 years’ duration, with worsening symptoms over the past 4 months. She was receiving sertra ... Full text Link to item Cite

Neuropsychological Assessments of Cognitive Impairment in Major Depressive Disorder: A Systematic Review and Meta-Analysis with Meta-Regression.

Journal Article Psychother Psychosom · 2024 INTRODUCTION: Cognitive dysfunction or deficits are common in patients with major depressive disorder (MDD). The current study systematically reviews and meta-analyzes multiple domains of cognitive impairment in patients with MDD. METHODS: PubMed/MEDLINE, ... Full text Link to item Cite

Life-Course Brain Health as a Determinant of Late-Life Mental Health: American Association for Geriatric Psychiatry Expert Panel Recommendations.

Journal Article Am J Geriatr Psychiatry · December 2023 This position statement of the Expert Panel on Brain Health of the American Association for Geriatric Psychiatry (AAGP) emphasizes the critical role of life course brain health in shaping mental well-being during the later stages of life. Evidence posits t ... Full text Link to item Cite

Neuroimaging features of depression-frailty phenotype in older adults: a pilot study.

Journal Article Int Psychogeriatr · December 2023 OBJECTIVE: Frailty and late-life depression (LLD) often coexist and share several structural brain changes. We aimed to study the joint effect LLD and frailty have on brain structure. DESIGN: Cross-sectional study. SETTING: Academic Health Center. PARTICIP ... Full text Link to item Cite

Brain Anatomy-Guided MRI Analysis for Assessing Clinical Progression of Cognitive Impairment with Structural MRI.

Conference Med Image Comput Comput Assist Interv · October 2023 Brain structural MRI has been widely used for assessing future progression of cognitive impairment (CI) based on learning-based methods. Previous studies generally suffer from the limited number of labeled training data, while there exists a huge amount of ... Full text Link to item Cite

Mid-life leukocyte telomere length and dementia risk: An observational and mendelian randomization study of 435,046 UK Biobank participants.

Journal Article Aging Cell · July 2023 Telomere attrition is one of biological aging hallmarks and may be intervened to target multiple aging-related diseases, including Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD). The objective of this study was to assess associatio ... Full text Link to item Cite

The Risk for Loneliness and Major Depression among Solo Agers.

Journal Article J Appl Gerontol · May 2023 Solo agers may be vulnerable to social isolation and mental health sequelae, particularly if they lack close family or friendship ties. This study examined associations among indicators of solo aging, frequency of loneliness, and Major Depressive Disorder ... Full text Link to item Cite

Association of Race, Ethnicity, Education, and Neighborhood Context With Dementia Prevalence and Cognitive Impairment Severity Among Older Adults Receiving Medicaid-Funded Home and Community-Based Services.

Journal Article Am J Geriatr Psychiatry · April 2023 OBJECTIVE: While racial, ethnic, and socioeconomic group disparities in cognitive impairment and dementia prevalence are well-documented among community-dwelling older adults, little is known about these disparity trends among older adults receiving Medica ... Full text Link to item Cite

High Risk of Substance Use Disorder-Related Outcomes in Veterans Released from Correctional Facilities in Mid to Late Life.

Journal Article J Gen Intern Med · April 2023 BACKGROUND: Veterans Affairs (VA) is likely to encounter a growing number of veterans returning to the community in mid to late life following incarceration (i.e., experiencing reentry). Yet, rates of negative health outcomes due to substance use disorders ... Full text Link to item Cite

Effects of Longitudinal Changes in Neuroticism and Stress on Cognitive Decline.

Journal Article Am J Geriatr Psychiatry · March 2023 OBJECTIVE: The relationships among depression, personality factors, stress, and cognitive decline in the elderly are complex. Depressed elders score higher in neuroticism than nondepressed older individuals. Independently, the presence of neuroticism and t ... Full text Link to item Cite

Reliable Cognitive Decline in Late-Life Major Depression.

Journal Article Arch Clin Neuropsychol · February 18, 2023 OBJECTIVE: Major depression in older adults increases the statistical likelihood of dementia. It is challenging to translate statistical evidence of cognitive decline at the group level into knowledge of individual cognitive outcomes. The objective of the ... Full text Link to item Cite

Brain morphometric features predict depression symptom phenotypes in late-life depression using a deep learning model.

Journal Article Front Neurosci · 2023 OBJECTIVES: Our objective was to use deep learning models to identify underlying brain regions associated with depression symptom phenotypes in late-life depression (LLD). PARTICIPANTS: Diagnosed with LLD (N = 116) and enrolled in a prospective treatment s ... Full text Link to item Cite

The neurobiology of apathy in depression and neurocognitive impairment in older adults: a review of epidemiological, clinical, neuropsychological and biological research.

Journal Article Transl Psychiatry · December 26, 2022 Apathy is a common condition that involves diminished initiative, diminished interest and diminished emotional expression or responsiveness. It is highly prevalent in the context of a variety of neuropsychiatric disorders and is related to poor health outc ... Full text Link to item Cite

Different loneliness types, cognitive function, and brain structure in midlife: Findings from the Framingham Heart Study

Journal Article eClinicalMedicine · November 1, 2022 Background: It remains unclear whether persistent loneliness is related to brain structures that are associated with cognitive decline and development of Alzheimer's disease (AD). This study aimed to investigate the relationships between different loneline ... Full text Cite

Understanding Clinical Progression of Late-Life Depression to Alzheimer's Disease Over 5 Years with Structural MRI.

Conference Mach Learn Med Imaging · September 2022 Previous studies have shown that late-life depression (LLD) may be a precursor of neurodegenerative diseases and may increase the risk of dementia. At present, the pathological relationship between LLD and dementia, in particularly Alzheimer's disease (AD) ... Full text Link to item Cite

Association of 1-year change in neuroticism and 3-year change in cognitive performance among older depressed adults.

Journal Article Int Psychogeriatr · July 2022 OBJECTIVES: The relationships among depression, personality factors, and cognitive decline in the elderly are complex. Depressed elders score higher in neuroticism than nondepressed older individuals. Presence of neuroticism worsens cognitive decline in de ... Full text Link to item Cite

Comparison of Long-Term Efficacy and Safety of Esketamine Nasal Spray Plus Oral Antidepressant in Younger Versus Older Patients With Treatment-Resistant Depression: Post-Hoc Analysis of SUSTAIN-2, a Long-Term Open-Label Phase 3 Safety and Efficacy Study.

Journal Article The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · May 2022 BackgroundOlder, compared with younger, patients with treatment-resistant depression (TRD) typically have lower response and remission rates with poorer tolerability to antidepressant treatment. This post-hoc analysis compared outcomes following t ... Full text Cite

Depression in Older Adults in the Primary Care Setting: Evaluation, Treatment and Consideration of Comorbid Medical Conditions and Cognitive Symptoms

Journal Article Connecticut Medicine · January 1, 2022 Major depression in older adults is a common disorder that is suitable for management in the primary care setting. This review will focus on screening, assessment, diagnosis, and treatment of geriatric depression in primary care. It will emphasize use of s ... Cite

Associations of loneliness with risk of Alzheimer's disease dementia in the Framingham Heart Study.

Journal Article Alzheimer's & dementia : the journal of the Alzheimer's Association · October 2021 IntroductionThe relationship between persistent loneliness and Alzheimer's disease (AD) is unclear. We examined the relationship between different types of mid-life loneliness and the development of dementia and AD.MethodsLoneliness was a ... Full text Cite

Effects of physical exercise on the aging brain across imaging modalities: A meta-analysis of neuroimaging studies in randomized controlled trials.

Journal Article Int J Geriatr Psychiatry · August 2021 BACKGROUND: Physical exercise is effective in protecting against age-related neurodegeneration and cognitive decline. Although there are many neuroimaging studies to evaluate the effect of physical exercise on aging brains, consistent conclusions are limit ... Full text Link to item Cite

Cognitive variability, brain aging, and cognitive decline in late-life major depression.

Journal Article Int J Geriatr Psychiatry · May 2021 OBJECTIVES: Older adults with late-life major depression (LLMD) are at increased risk of dementia. Dispersion, or within-person performance variability across cognitive tests, is a potential marker of cognitive decline. This study examined group difference ... Full text Link to item Cite

Structural brain changes and neuroticism in late-life depression: a neural basis for depression subtypes.

Journal Article International psychogeriatrics · May 2021 The neurobiological basis of neuroticism in late-life depression (LLD) is understudied. We hypothesized that older depressed subjects scoring high in measures of neuroticism would have smaller hippocampal and prefrontal volumes compared with non-neurotic o ... Full text Cite

Apathy: Neurobiology, assessment and treatment

Journal Article Clinical Psychopharmacology and Neuroscience · May 1, 2021 Apathy is a highly prevalent, disabling and treatment resistant syndrome. It is defined as a quantitative reduction of goal-directed activity in comparison to the patient’s previous level of in multiple dimensions including behavior/cognition, emotion and ... Full text Cite

Deep factor regression for computer-aided analysis of major depressive disorders with structural MRI data

Conference Proceedings - International Symposium on Biomedical Imaging · April 13, 2021 Major depressive disorder (MDD) is a prevalent and debilitating psychiatric mood disorder that affects millions of people worldwide. Conventional methods for MDD severity diagnosis usually rely on neuropsychological assessments that are subjective and susc ... Full text Cite

Pharmacist Identification of Medication Therapy Problems Involving Cognition Among Older Adults Followed by a Home-Based Care Team.

Journal Article Drugs Aging · February 2021 BACKGROUND: Dementia, depression, and delirium alone or in combination (3Ds) can threaten independence among older adults, and polypharmacy may further accelerate decline. Clinical pharmacists can play an important role on multidisciplinary home-based care ... Full text Link to item Cite

The Interaction of Personality and Social Support on Prospective Suicidal Ideation in Men and Women With Late-Life Depression.

Journal Article Am J Geriatr Psychiatry · January 2021 OBJECTIVE: Evidence suggests a cross-sectional association between personality traits and suicidal ideation in LLD. Yet, it is unclear how personality may influence suicidal ideation over time in LLD, or whether such an association would be moderated by ps ... Full text Link to item Cite

Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort.

Journal Article J Alzheimers Dis · 2021 BACKGROUND: Brain iron deposition occurs in dementia. In European ancestry populations, the HFE p.C282Y variant can cause iron overload and hemochromatosis, mostly in homozygous males. OBJECTIVE: To estimate p.C282Y associations with brain MRI features plu ... Full text Link to item Cite

The Effects of Locus of Control, Social Support, and Stigma on the HIV Care Continuum in an Aging HIV-infected Population

Journal Article Connecticut Medicine · January 1, 2021 Research on how psychosocial factors affect older people living with HIV is limited despite the growing demographic. The purpose of this study was to determine how locus of control (LOC), HIV stigma, and social support affect older patients' progression th ... Cite

Prevalence of Treatment for Depression Among US Adults Who Screen Positive for Depression, 2007-2016.

Journal Article JAMA Psychiatry · November 1, 2020 This cohort study uses data from the National Health and Nutrition Examination Survey to examine changes in the prevalence of mental health treatment among US adults who screened positive for depression between 2007 and 2016. ... Full text Link to item Cite

Major depressive disorder and impaired health-related quality of life among US older adults.

Journal Article Int J Geriatr Psychiatry · October 2020 OBJECTIVES: To examine the association of current and past major depressive disorder (MDD) and measures of health-related quality of life (HRQOL) in a nationally representative sample of older adults. METHODS: Cross-sectional analysis of the 2012 to 2013 N ... Full text Link to item Cite

Ethical and Logistical Considerations of Caring for Older Adults on Inpatient Psychiatry During the COVID-19 Pandemic.

Journal Article Am J Geriatr Psychiatry · August 2020 The coronavirus disease 2019 (COVID-19) pandemic has brought challenges to delivery of care for older adults on inpatient psychiatry. We describe two cases: patient A, a 62-year-old woman who initially refused screening for potential COVID-19, bringing up ... Full text Link to item Cite

Clinical trial testing in-home multidisciplinary care management for older adults with cognitive vulnerability: Rationale and study design.

Journal Article Contemp Clin Trials · May 2020 Care management approaches are being widely tested in the Medicare-eligible population to manage chronic conditions, but few have focused on cognitive vulnerability as the pathway to optimizing independence in the community-dwelling older population. Cogni ... Full text Link to item Cite

Functional disability, depression, and suicidal ideation in older prisoners.

Journal Article J Affect Disord · April 1, 2020 BACKGROUND: The population of older prisoners (age ≥50), a group with high suicide rates, is growing. We sought to explore the associations among functional disability, depression, and suicidal ideation (SI) among older prisoners, focusing on the mediating ... Full text Link to item Cite

Efficacy and Safety of Esketamine Nasal Spray Plus an Oral Antidepressant in Elderly Patients With Treatment-Resistant Depression-TRANSFORM-3.

Journal Article Am J Geriatr Psychiatry · February 2020 BACKGROUND: Elderly patients with major depression have a poorer prognosis, are less responsive to treatment, and show greater functional decline compared with younger patients, highlighting the need for effective treatment. METHODS: This phase 3 double-bl ... Full text Link to item Cite

Dynamic changes in thalamic connectivity following stress and its association with future depression severity.

Journal Article Brain Behav · December 2019 INTRODUCTION: Tracking stress-induced brain activity and connectivity dynamically and examining activity/connectivity-associated recovery ability after stress might be an effective way of detecting stress vulnerability. METHODS: Using two widely used stres ... Full text Link to item Cite

Functional connectivity predictors of acute depression treatment outcome.

Journal Article Int Psychogeriatr · December 2019 Few studies have examined functional connectivity (FC) patterns using functional magnetic resonance imaging (fMRI) to predict outcomes in late-life depression. We hypothesized that FC within and between frontal and limbic regions would be associated with 1 ... Full text Link to item Cite

Is it time to do away with disorders in the very old?

Journal Article Int Psychogeriatr · November 2019 Full text Link to item Cite

Associations of Adverse Childhood Experiences with Past-Year DSM-5 Psychiatric and Substance Use Disorders in Older Adults.

Journal Article J Am Geriatr Soc · October 2019 OBJECTIVES: To examine the prevalence of adverse childhood experiences (ACEs) and the associations of ACEs with psychiatric and substance use disorders among older adults in the United States. DESIGN: Cross-sectional analysis of the 2012-2013 National Epid ... Full text Link to item Cite

Adverse Effects of Pharmacologic Treatments of Major Depression in Older Adults.

Journal Article J Am Geriatr Soc · August 2019 OBJECTIVES: To assess adverse effects of pharmacologic antidepressants for treatment of major depressive disorder (MDD) in adults 65 years of age or older. DESIGN: Systematic review and meta-analysis. SETTING: Specialist or generalist outpatient setting, r ... Full text Link to item Cite

Training the Next Generation of Geriatric-Focused Clinical Neuroscientists.

Journal Article Am J Geriatr Psychiatry · July 2019 It remains challenging to integrate clinical neuroscience into clinical practice. Hindrances at the training level (e.g., lack of qualified faculty and curriculum) contribute to this impasse. To help address this, we present a model of training in clinical ... Full text Link to item Cite

Increased ventromedial prefrontal cortex activity and connectivity predict poor sertraline treatment outcome in late-life depression.

Journal Article Int J Geriatr Psychiatry · May 2019 OBJECTIVE: Previous studies of imaging predictors on acute treatment response in late-life depression (LLD) demonstrated that poor response to selective serotonin reuptake inhibitors (SSRIs) is associated with pre-treatment low functional connectivity (FC) ... Full text Link to item Cite

Increased plasma complement factor H is associated with geriatric depression.

Journal Article Int Psychogeriatr · January 2019 UNLABELLED: ABSTRACTBackground:Complement factor H (CFH) plays a key role in regulating the cascade of the alternative pathway of the complement system. Dysregulation of CFH may be involved in the pathophysiology of various inflammation-mediated diseases i ... Full text Link to item Cite

Recent advances in the use of imaging in psychiatry: functional magnetic resonance imaging of large-scale brain networks in late-life depression.

Journal Article F1000Res · 2019 Advances in neuroimaging have identified neural systems that contribute to clinical symptoms that occur across various psychiatric disorders. This transdiagnostic approach to understanding psychiatric illnesses may serve as a precise guide to identifying d ... Full text Link to item Cite

Perspectives on the Management of Vascular Depression.

Journal Article Am J Psychiatry · December 1, 2018 In the next few years, the youngest of the baby boomers will reach age 65, resulting in the greatest proportion of elderly adults in US history. Concurrent with this demographic change is the growing number of adults living with chronic conditions that inc ... Full text Link to item Cite

Increased Risk of Suicide Attempts and Unintended Death Among Those Transitioning From Prison to Community in Later Life.

Journal Article Am J Geriatr Psychiatry · November 2018 OBJECTIVE: The number of individuals transitioning from correctional facilities to community in later life (age ≥50 ) is increasing. We sought to determine if later-life prison release is a risk factor for suicidal behavior and death by accidental injury, ... Full text Link to item Cite

Physical exercise increases involvement of motor networks as a compensatory mechanism during a cognitively challenging task.

Journal Article Int J Geriatr Psychiatry · August 2018 OBJECTIVE: Neuroimaging studies suggest that older adults may compensate for declines in cognitive function through neural compensation and reorganization of neural resources. While neural compensation as a key component of cognitive reserve is an importan ... Full text Link to item Cite

Presence of neuroticism and antidepressant remission rates in late-life depression: results from the Neurobiology of Late-Life Depression (NBOLD) study.

Journal Article Int Psychogeriatr · July 2018 ABSTRACTNeuroticism in older adults is common yet understudied, particularly its effects on depression treatment outcomes. We hypothesized that presence of high neuroticism would be associated with lower 12-week remission rates in older depressed sertralin ... Full text Link to item Cite

Predictors of recurrence in remitted late-life depression.

Journal Article Depress Anxiety · July 2018 BACKGROUND: Late-life depression (LLD) is associated with a fragile antidepressant response and high recurrence risk. This study examined what measures predict recurrence in remitted LLD. METHODS: Individuals of age 60 years or older with a Diagnostic and ... Full text Link to item Cite

State of the Science of Neural Systems in Late-Life Depression: Impact on Clinical Presentation and Treatment Outcome.

Journal Article J Am Geriatr Soc · April 2018 Major depression in older adults, or late-life depression (LLD), is a common and debilitating psychiatric disorder that increases the risk of morbidity and mortality. Although the effects of LLD make it important to achieve a diagnosis and start treatment ... Full text Link to item Cite

A new measure for neural compensation is positively correlated with working memory and gait speed

Journal Article Frontiers in Aging Neuroscience · March 19, 2018 Neuroimaging studies suggest that older adults may compensate for declines in brain function and cognition through reorganization of neural resources. A limitation of prior research is reliance on between-group comparisons of neural activation (e.g., young ... Full text Cite

Putamen Volume Differences Among Older Adults: Depression Status, Melancholia, and Age.

Journal Article J Geriatr Psychiatry Neurol · January 2018 BACKGROUND: Individuals with major depressive disorder (MDD) may exhibit smaller striatal volumes reflecting deficits in the reward circuit. Deficits may change with age and be more pronounced among the melancholic subtype. Limited research has investigate ... Full text Link to item Cite

Effects of stressful life events on cerebral white matter hyperintensity progression.

Journal Article Int J Geriatr Psychiatry · December 2017 OBJECTIVE: Exposure to stressful events is associated with both occurrence of depression and also vascular disease. The objective of this study was to determine whether higher levels of stress exposure was related to measures of pathological brain aging, s ... Full text Link to item Cite

Negative Affectivity, Aging, and Depression: Results From the Neurobiology of Late-Life Depression (NBOLD) Study.

Journal Article Am J Geriatr Psychiatry · October 2017 OBJECTIVE: Neuroticism is a common yet understudied condition in older adults. We hypothesized that presence of high negativity affectivity (NA), a key feature of neuroticism, would be associated with different prefrontal cortex (PFC) activity and connecti ... Full text Link to item Cite

Longitudinal Cognitive Outcomes of Clinical Phenotypes of Late-Life Depression.

Journal Article Am J Geriatr Psychiatry · October 2017 OBJECTIVE: Late-life depression is associated with cognitive deficits and increased risk for cognitive decline. The purpose of the study was to determine whether clinical characteristics could serve as phenotypes informative of subsequent cognitive decline ... Full text Link to item Cite

Length of axons expressing the serotonin transporter in orbitofrontal cortex is lower with age in depression.

Journal Article Neuroscience · September 17, 2017 Studies of major depressive disorder (MDD) in postmortem brain tissue report enhanced binding to inhibitory serotonin-1A autoreceptors in midbrain dorsal raphe and reductions in length of axons expressing the serotonin transporter (SERT) in dorsolateral pr ... Full text Link to item Cite

Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms

Journal Article Alzheimer's and Dementia: Translational Research and Clinical Interventions · September 1, 2017 Neuropsychiatric symptoms (NPSs) are hallmarks of Alzheimer's disease (AD), causing substantial distress for both people with dementia and their caregivers, and contributing to early institutionalization. They are among the earliest signs and symptoms of n ... Full text Cite

Late-Life Depression and the Prodromes of Dementia.

Journal Article JAMA Psychiatry · July 1, 2017 Full text Link to item Cite

Neuroticism Traits Selectively Impact Long Term Illness Course and Cognitive Decline in Late-Life Depression.

Journal Article Am J Geriatr Psychiatry · March 2017 OBJECTIVES: Neuroticism is a broad construct that conveys a predisposition to experience psychological distress and negative mood states. Vulnerability to stress (VS) is one neuroticism trait that has been linked to worse mood and cognitive outcomes in old ... Full text Link to item Cite

Decreased between-hemisphere connectivity strength and network efficiency in geriatric depression.

Journal Article Hum Brain Mapp · January 2017 White matter (WM) lesions have been recognized as a key etiological factor in geriatric depression. However, little is known about the topological pattern changes of WM in geriatric depression in the remitted state (RGD) and its relationship to depressive ... Full text Link to item Cite

Multiple Neuroimaging Measures for Examining Exercise-induced Neuroplasticity in Older Adults: A Quasi-experimental Study.

Journal Article Front Aging Neurosci · 2017 Physical exercise can improve physical and mental health. A number of imaging studies have examined the role of neuroplasticity in improving cognition with physical exercise; however, such neuroplasticity changes are not consistent across the reports partl ... Full text Link to item Cite

Cortical brain volume abnormalities associated with few or multiple neuropsychiatric symptoms in Alzheimer's disease.

Journal Article PLoS One · 2017 New research on assessing neuropsychiatric manifestations of Alzheimer´s Disease (AD) involves grouping neuropsychiatric symptoms into syndromes. Yet this approach is limited by high inter-subject variability in neuropsychiatric symptoms and a relatively l ... Full text Link to item Cite

Vascular depression consensus report - a critical update.

Journal Article BMC Med · November 3, 2016 BACKGROUND: Vascular depression is regarded as a subtype of late-life depression characterized by a distinct clinical presentation and an association with cerebrovascular damage. Although the term is commonly used in research settings, widely accepted diag ... Full text Link to item Cite

A Novel Strategy for Continuation ECT in Geriatric Depression: Phase 2 of the PRIDE Study.

Journal Article Am J Psychiatry · November 1, 2016 OBJECTIVE: The randomized phase (phase 2) of the Prolonging Remission in Depressed Elderly (PRIDE) study evaluated the efficacy and tolerability of continuation ECT plus medication compared with medication alone in depressed geriatric patients after a succ ... Full text Link to item Cite

Right Unilateral Ultrabrief Pulse ECT in Geriatric Depression: Phase 1 of the PRIDE Study.

Journal Article Am J Psychiatry · November 1, 2016 OBJECTIVE: The Prolonging Remission in Depressed Elderly (PRIDE) study evaluated the efficacy of right unilateral ultrabrief pulse electroconvulsive therapy (ECT) combined with venlafaxine for the treatment of geriatric depression. METHOD: PRIDE was a two- ... Full text Link to item Cite

Appetite and Weight Loss Symptoms in Late-Life Depression Predict Dementia Outcomes.

Journal Article Am J Geriatr Psychiatry · October 2016 OBJECTIVE: Identify depression symptoms during active late-life depression (LLD) that predict conversion to dementia. METHODS: The authors followed a cohort of 290 participants from the Neurocognitive Outcomes of Depression in the Elderly study. All partic ... Full text Link to item Cite

J'accuse! depression as a likely culprit in cases of AD.

Journal Article Int Psychogeriatr · September 2016 Clinicians have long appreciated the links between depression, cognitive impairment, and development of Alzheimer's disease (AD) and other dementias. More recently, investigators in the fields of epidemiology, genetics, neuroimaging, and neuropathology hav ... Full text Link to item Cite

Heterogeneity in the three-year course of major depression among older adults.

Journal Article Int J Geriatr Psychiatry · July 2016 OBJECTIVE: The objective of this research was to identify distinct trajectories of recovery in older depressed patients in order to identify optimal samples and points for interventions. METHODS: The sample was 368 patients ages 60 years and older diagnose ... Full text Link to item Cite

Characteristics of neurocognitive functions in mild cognitive impairment with depression.

Journal Article Int Psychogeriatr · July 2016 BACKGROUND: Previous studies suggest that there is a strong association between depression and cognitive decline, and that concurrent depressive symptoms in MCI patients could contribute to a difference in neurocognitive characteristics compared to MCI pat ... Full text Link to item Cite

Physical frailty in late-life depression is associated with deficits in speed-dependent executive functions.

Journal Article Int J Geriatr Psychiatry · May 2016 OBJECTIVE: The aim of this study was to examine the association between physical frailty and neurocognitive performance in late-life depression (LLD). METHODS: Cross-sectional design using baseline data from a treatment study of late-life depression was us ... Full text Link to item Cite

Amyloid-associated depression and ApoE4 allele: longitudinal follow-up for the development of Alzheimer's disease.

Journal Article Int J Geriatr Psychiatry · March 2016 BACKGROUND: Amyloid-associated depression is associated with cognitive impairment cross sectionally. This follow-up study was to determine the relationship between amyloid-associated depression and the development of Alzheimer's disease (AD). METHODS: Two ... Full text Link to item Cite

A Call to Restructure Psychiatry General and Subspecialty Training.

Journal Article Acad Psychiatry · February 2016 Dire shortages of psychiatrists with special expertise in geriatrics, substance abuse, forensics, and psychosomatics create barriers to care for populations with complex mental disorders and pose a significant public health concern. To address these dispar ... Full text Link to item Cite

Late-life Depression Modifies the Association Between Cerebral White Matter Hyperintensities and Functional Decline Among Older Adults.

Journal Article Am J Geriatr Psychiatry · January 2016 OBJECTIVE: Vascular lesions seen through brain imaging as hyperintensities are associated with both depression and functional impairment in older adults. Our objective was to determine if the relationship between the volume of cerebral white matter hyperin ... Full text Link to item Cite

Perspectives on the Happiness of Community-Dwelling Elderly in Korea.

Journal Article Psychiatry Investig · January 2016 OBJECTIVE: A community survey was performed to investigate the factors and perspectives associated with happiness among the elderly in Korea (≥60 years). METHODS: Eight hundred volunteers selected from participants in the Ansan Geriatric study (AGE study) ... Full text Link to item Cite

Basolateral amygdala volume and cell numbers in major depressive disorder: a postmortem stereological study.

Journal Article Brain Struct Funct · January 2016 Functional imaging studies consistently report abnormal amygdala activity in major depressive disorder (MDD). Neuroanatomical correlates are less clear: imaging studies have produced mixed results on amygdala volume, and postmortem neuroanatomic studies ha ... Full text Link to item Cite

The Treatment of Behavioral and Psychological Symptoms of Dementia: Weighing Benefits and Risks.

Journal Article Curr Alzheimer Res · 2016 Behavioral and psychological symptoms of dementia (BPSD) are common among patients with dementia. BPSD have significant implications on outcomes for patients and caregivers. Available literature for pharmacological approaches to BPSD is sparse and at times ... Full text Link to item Cite

Systems Neuroscience in Late-Life Depression

Chapter · January 1, 2016 Major depression in the elderly is a heterogeneous disorder that presents with a constellation of cognitive and affective symptoms. Neuroimaging has helped elucidate the contributions of dorsal-cognitive and ventral-affective brain regions to the pathophys ... Full text Cite

Methodology and preliminary results from the neurobiology of late-life depression study.

Journal Article Int Psychogeriatr · December 2015 BACKGROUND: We sought to investigate the relationship between neuroticism and depression in an elderly cohort. In this paper, we describe the methods of an National Institute of Mental Health-NIMH-supported study and present findings among the cohort enrol ... Full text Link to item Cite

Sleep Disturbances in the Elderly.

Journal Article Psychiatr Clin North Am · December 2015 Sleep disturbances are a common presenting symptom of older-age adults to their physicians. This article explores normal changes in sleep pattern with aging and primary sleep disorders in the elderly. Behavioral factors and primary psychiatric disorders af ... Full text Link to item Cite

Cognitive functioning throughout the treatment history of clinical late-life depression.

Journal Article Int J Geriatr Psychiatry · October 2015 OBJECTIVE: Previous investigations into the relationship between late-life depressive symptoms and cognitive functioning have resulted in mixed findings concerning whether or not depressive symptoms and cognitive functioning are related. The mixed reports ... Full text Link to item Cite

Inflammation Markers and Major Depressive Disorder in Patients With Chronic Heart Failure: Results From the Sertraline Against Depression and Heart Disease in Chronic Heart Failure Study.

Journal Article Psychosom Med · September 2015 BACKGROUND: Major depressive disorder (MDD) and chronic heart failure (CHF) have in common heightening states of inflammation, manifested by elevated inflammation markers such as C-reactive protein. This study compared inflammatory biomarker profiles in pa ... Full text Link to item Cite

Appetite loss and neurocognitive deficits in late-life depression.

Journal Article Int J Geriatr Psychiatry · June 2015 OBJECTIVES: This study aimed to examine the association of appetite loss symptoms to neurocognitive performance in late-life depression (LLD). METHODS: This study used cross-sectional data from individuals aged 60+ years with major depressive disorder (N = ... Full text Link to item Cite

Disability but not social support predicts cognitive deterioration in late-life depression.

Journal Article Int Psychogeriatr · May 2015 BACKGROUND: Depression in late life is a risk factor for cognitive decline. Depression is also associated with increased disability and social support deficits; these may precede conversion to dementia and inform risk. In this study, we examined if baselin ... Full text Link to item Cite

Anxiety symptoms in amnestic mild cognitive impairment are associated with medial temporal atrophy and predict conversion to Alzheimer disease.

Journal Article Am J Geriatr Psychiatry · May 2015 OBJECTIVE: To test the hypothesis that anxiety in amnestic mild cognitive impairment (aMCI) increases rates of conversion to Alzheimer disease (AD) and to identify potential neural mechanisms underlying such an association. METHODS: Participants (N = 376) ... Full text Link to item Cite

National Institutes of Health Pathways to Prevention Workshop: the role of opioids in the treatment of chronic pain.

Journal Article Ann Intern Med · February 17, 2015 This National Institutes of Health (NIH) Pathways to Prevention Workshop was cosponsored by the NIH Office of Disease Prevention (ODP), the NIH Pain Consortium, the National Institute on Drug Abuse, and the National Institute of Neurological Disorders and ... Full text Link to item Cite

Factors associated with cognitive evaluations in the United States.

Journal Article Neurology · January 6, 2015 OBJECTIVE: We aimed to explore factors associated with clinical evaluations for cognitive impairment among older residents of the United States. METHODS: Two hundred ninety-seven of 845 subjects in the Aging, Demographics, and Memory Study (ADAMS), a natio ... Full text Link to item Cite

Altered Synchronizations among Neural Networks in Geriatric Depression.

Journal Article Biomed Res Int · 2015 Although major depression has been considered as a manifestation of discoordinated activity between affective and cognitive neural networks, only a few studies have examined the relationships among neural networks directly. Because of the known disconnecti ... Full text Link to item Cite

Agitation in cognitive disorders: International Psychogeriatric Association provisional consensus clinical and research definition.

Journal Article Int Psychogeriatr · January 2015 BACKGROUND: Agitation is common across neuropsychiatric disorders and contributes to disability, institutionalization, and diminished quality of life for patients and their caregivers. There is no consensus definition of agitation and no widespread agreeme ... Full text Link to item Cite

Hippocampus atrophy and the longitudinal course of late-life depression.

Journal Article Am J Geriatr Psychiatry · December 2014 OBJECTIVES: Smaller hippocampal volumes are observed in depression but it remains unclear how antidepressant response and persistent depression relate to changes in hippocampal volume. We examined the longitudinal relationship between hippocampal atrophy a ... Full text Link to item Cite

Usefulness of the Patient Health Questionnaire-9 for Korean medical students.

Journal Article Acad Psychiatry · December 2014 OBJECTIVE: Depression may be highly prevalent among medical students, lowering their functioning and quality of life. Using appropriate extant depression scales to screen for depression and determining factors associated with depression can be helpful in m ... Full text Link to item Cite

Amnestic mild cognitive impairment and incident dementia and Alzheimer's disease in geriatric depression.

Journal Article Int Psychogeriatr · December 2014 BACKGROUND: Memory impairment in geriatric depression is understudied, but may identify individuals at risk for development of dementia and Alzheimer's disease (AD). Using a neuropsychologically based definition of amnestic mild cognitive impairment (aMCI) ... Full text Link to item Cite

Diffusion tensor imaging studies in late-life depression: systematic review and meta-analysis.

Journal Article Int J Geriatr Psychiatry · December 2014 OBJECTIVES: Late-life depression (LLD) is the association with more cerebrovascular susceptibilities and white matter damage that can be assessed with diffusion tensor imaging (DTI). To better understand the white matter pathological alterations in LLD, we ... Full text Link to item Cite

Association of gene variants of the renin-angiotensin system with accelerated hippocampal volume loss and cognitive decline in old age.

Journal Article Am J Psychiatry · November 1, 2014 OBJECTIVE: Genetic factors confer risk for neuropsychiatric phenotypes, but the polygenic etiology of these phenotypes makes identification of genetic culprits challenging. An approach to this challenge is to examine the effects of genetic variation on rel ... Full text Link to item Cite

Use of diuretics is associated with reduced risk of Alzheimer's disease: the Cache County Study.

Journal Article Neurobiol Aging · November 2014 Although the use of antihypertensive medications has been associated with reduced risk of Alzheimer's disease (AD), it remains unclear which class provides the most benefit. The Cache County Study of Memory Health and Aging is a prospective longitudinal co ... Full text Link to item Cite

Influence of the number and severity of somatic symptoms on the severity of depression and suicidality in community-dwelling elders.

Journal Article Asia Pac Psychiatry · September 2014 INTRODUCTION: Older adults commonly experience somatic symptoms, and those who do are more likely to have depressive disorders as well. Our goal in this study is to examine the influence of the number and severity of somatic symptoms on the severity of dep ... Full text Link to item Cite

Melancholia in later life: late and early onset differences in presentation, course, and dementia risk.

Journal Article Int J Geriatr Psychiatry · September 2014 OBJECTIVES: Depression is a risk factor for cognitive decline and dementia. This risk may vary with age of onset and depression subtype. Late onset depression (LOD, 60 years and older) is associated with more cognitive decline, whereas early onset depressi ... Full text Link to item Cite

Relative effectiveness of reappraisal and distraction in regulating emotion in late-life depression.

Journal Article Am J Geriatr Psychiatry · September 2014 OBJECTIVES: The present study compares the effectiveness of two strategies, reappraisal and distraction, in reducing negative affect in older adults induced by focusing on personally relevant negative events and stressors. PARTICIPANTS: 30 adults with majo ... Full text Link to item Cite

Elevated brain lesion volumes in older adults who use calcium supplements: a cross-sectional clinical observational study.

Journal Article Br J Nutr · July 28, 2014 Recent studies have implicated Ca supplements in vascular risk elevation, and therefore these supplements may also be associated with the occurrence of brain lesions (or hyperintensities) in older adults. These lesions represent damage to brain tissue that ... Full text Link to item Cite

Cingulum bundle white matter lesions influence antidepressant response in late-life depression: a pilot study.

Journal Article J Affect Disord · June 2014 BACKGROUND: Late-life depression is associated with white matter hyperintense lesions (WMLs) occurring in specific fiber tracts. In this study, we sought to determine if greater WML severity in the cingulum bundle or uncinate fasciculus was associated with ... Full text Link to item Cite

Vascular lesions and functional limitations among older adults: does depression make a difference?

Journal Article Int Psychogeriatr · May 9, 2014 ABSTRACT Background: The association between disability and depression is complex, with disability well established as a correlate and consequence of late life depression. Studies in community samples report that greater volumes of cerebral white matter hy ... Full text Link to item Cite

Angiotensin converting enzyme inhibitors and Alzheimer disease in the presence of the apolipoprotein E4 allele.

Journal Article Am J Geriatr Psychiatry · February 2014 OBJECTIVE: The effect of angiotensin converting enzyme (ACE) inhibitors on Alzheimer disease (AD) remains unclear, with conflicting results reported. We studied the interaction of the Apolipoprotein E (ApoE) genotype and ACE inhibitors on AD. METHODS: This ... Full text Link to item Cite

Neuropsychological indicators of preclinical Alzheimer's disease among depressed older adults.

Journal Article Neuropsychol Dev Cogn B Aging Neuropsychol Cogn · 2014 Older adults with major depressive disorder (MDD) may also have preclinical Alzheimer's disease (AD). Differential diagnosis is quite challenging due to the overlapping symptoms of MDD and AD. In the current study, we predicted that impaired long-term memo ... Full text Link to item Cite

Differences between suicide attempters and nonattempters in depressed older patients: depression severity, white-matter lesions, and cognitive functioning.

Journal Article Am J Geriatr Psychiatry · January 2014 OBJECTIVES: The population of older adults with major depressive disorder (MDD) has the highest rate of suicide. White-matter brain lesions (WML) are a potential biologic marker for suicidality in young and middle-aged adults and are correlated with cognit ... Full text Link to item Cite

Resilience in the face of chronic illness and family caregiving in middle and later life

Journal Article Psychiatric Annals · December 1, 2013 CME EDUCATIONAL OBJECTIVES 1. Understand the role of perceived personal control and accommodative strategies in adults coping with common challenges of old age. 2. Describe the effect of positive affect on resilience in older adults. 3. Discuss a proposed ... Full text Cite

What are the causes of late-life depression?

Journal Article Psychiatr Clin North Am · December 2013 Although depression in old age is less common than depression in younger populations, it still affects more than 1 million community-living older adults. Depression in late life has been associated with reduced quality of life and increased mortality from ... Full text Link to item Cite

Clinical outcomes of older depressed patients with and without comorbid neuroticism.

Journal Article Int Psychogeriatr · December 2013 BACKGROUND: Neuroticism is a psychological construct that includes tendency to exhibit negative affect (NA), having poor stress tolerance and being at risk for depression and anxiety disorders. The consequences of neuroticism in the elderly adults are unde ... Full text Link to item Cite

Quality of life and physical activity associated to lower prevalence of depression in community-dwelling elderly subjects from Sao Paulo.

Journal Article J Affect Disord · September 5, 2013 BACKGROUND: Studies investigating major depression and associated factors in older people from developing countries are scarce. METHODS: Cross-sectional study of a community-based sample of 1563 elderly subjects aged 60 years or older from Sao Paulo, Brazi ... Full text Link to item Cite

Folate metabolism genes, dietary folate and response to antidepressant medications in late-life depression.

Journal Article Int J Geriatr Psychiatry · September 2013 OBJECTIVE: The primary aims of this study were to (i) determine whether folate metabolism genetic polymorphisms predict age of onset and occurrence of late life depression; and (ii) determine whether folate metabolism genetic polymorphisms predict response ... Full text Link to item Cite

Morphometric analysis of vascular pathology in the orbitofrontal cortex of older subjects with major depression.

Journal Article Int J Geriatr Psychiatry · September 2013 OBJECTIVE: Late-life depression has been associated with risk for cerebrovascular pathology, as demonstrated in neuroimaging studies of older depressed patients, as well as mood disorder following cerebrovascular accidents. However, more research is needed ... Full text Link to item Cite

Sensitivity of cognitive tests in four cognitive domains in discriminating MDD patients from healthy controls: a meta-analysis.

Journal Article Int Psychogeriatr · September 2013 BACKGROUND: We performed a meta-analysis in order to determine which neuropsychological domains and tasks would be most sensitive for discriminating between patients with major depressive disorder (MDD) and healthy controls. METHODS: Relevant articles were ... Full text Link to item Cite

Stressful life events and cognitive decline in late life: moderation by education and age. The Cache County Study.

Journal Article Int J Geriatr Psychiatry · August 2013 OBJECTIVE: Stressful life events (SLE) have been associated with increased dementia risk, but their association with cognitive decline has been inconsistent. In a longitudinal population-based study of older individuals, we examined the association between ... Full text Link to item Cite

Serum ionized calcium may be related to white matter lesion volumes in older adults: a pilot study.

Journal Article Nutrients · June 18, 2013 White matter lesions have detrimental effects upon older adults, while serum calcium levels have been associated with elevated vascular risk and may be associated with these lesions. Depression, a serious mental disorder characterized by disturbances in ca ... Full text Link to item Cite

Late-life onset bipolar disorder presenting as a case of pseudo-dementia: a case discussion and review of literature.

Journal Article Yale J Biol Med · June 2013 Depression and comorbid cognitive impairment in the elderly can be difficult to distinguish from dementia. Adding to the complex differential is that depression may be part of a bipolar illness rather than a unipolar mood disorder. A diligent workup and cl ... Link to item Cite

Validation of a treatment algorithm for major depression in an older Brazilian sample.

Journal Article Int J Geriatr Psychiatry · June 2013 OBJECTIVE: The aim of this study was to investigate the effectiveness of a modified version of the Duke Somatic Algorithm Treatment for Geriatric Depression (STAGED) in a Brazilian sample of older patients with major depression. Besides, we aimed to invest ... Full text Link to item Cite

Negative life stress and longitudinal hippocampal volume changes in older adults with and without depression.

Journal Article J Psychiatr Res · June 2013 Major depressive disorder is associated with smaller hippocampal volumes but the mechanisms underlying this relationship are unclear. To examine the effect of environmental influences, we examined the relationship between self-reported stressors and two-ye ... Full text Link to item Cite

Neuropsychological predictors of dementia in late-life major depressive disorder.

Journal Article Am J Geriatr Psychiatry · March 2013 OBJECTIVE: Major depressive disorder is a likely risk factor for dementia, but some cases of major depressive disorder in older adults may actually represent a prodrome of this condition. The purpose of this study was to use neuropsychological test scores ... Full text Link to item Cite

Fiber tract-specific white matter lesion severity Findings in late-life depression and by AGTR1 A1166C genotype.

Journal Article Hum Brain Mapp · February 2013 Past work demonstrated that late-life depression is associated with greater severity of ischemic cerebral hyperintense white matter lesions, particularly frontal lesions. However, these lesions are also associated with other neuropsychiatric deficits, so t ... Full text Link to item Cite

Structural brain changes as biomarkers and outcome predictors in patients with late-life depression: a cross-sectional and prospective study.

Journal Article PLoS One · 2013 The relationship between structural changes in grey matter and treatment response in patients with late-life depression remains an intriguing area of research. This magnetic resonance imaging (MRI) study compares the baseline grey matter volume of elderly ... Full text Link to item Cite

The relationship of religious involvement indicators and social support to current and past suicidality among depressed older adults.

Journal Article Aging Ment Health · 2013 Elderly people, particularly those with major depression, are at the highest risk for suicide than any other age group. Religious involvement is associated with a range of health outcomes including lower odds of death by suicide. However, not much is known ... Full text Link to item Cite

Association of five-factor model personality domains and facets with presence, onset, and treatment outcomes of major depression in older adults.

Journal Article Am J Geriatr Psychiatry · January 2013 OBJECTIVES: To assess the relationship of multiple domains and facets of the five-factor model of personality with presence, onset, and severity of late-life depression. DESIGN: Cross-sectional analysis of depression status, and age of onset. Retrospective ... Full text Link to item Cite

A longitudinal study of differences in late- and early-onset geriatric depression: depressive symptoms and psychosocial, cognitive, and neurological functioning.

Journal Article Aging Ment Health · 2013 OBJECTIVES: Studies suggest early-onset depression (EOD) is associated with a more severe course of the depressive disorder, while late-onset depression (LOD) is associated with more cognitive and neuroimaging changes. This study examined if older adults w ... Full text Link to item Cite

Reduced comparison speed during visual search in late life depression.

Journal Article J Clin Exp Neuropsychol · 2013 Slowed information processing is a prominent deficit in late-life depression (LLD). To better differentiate processing speed components in LLD, we examined characteristics of visual search performance in 32 LLD and 32 control participants. Data showed spec ... Full text Open Access Link to item Cite

Fruit, vegetable, and antioxidant intakes are lower in older adults with depression.

Journal Article J Acad Nutr Diet · December 2012 Studies have shown an association between depression and both antioxidant levels and oxidant stress, but generally have not included intakes of antioxidants and antioxidant-rich fruits and vegetables. This study examined the cross-sectional associations be ... Full text Link to item Cite

Longitudinal relationships of religion with posttreatment depression severity in older psychiatric patients: Evidence of direct and indirect effects

Journal Article Depression Research and Treatment · December 1, 2012 Psychiatric patients (age 59+) were assessed before study treatment for major depressive disorder, and again after 3 months. Measures taken before study treatment included facets of religiousness (subjective religiosity, private prayer, worship attendance, ... Full text Open Access Cite

Memory deficit associated with worse functional trajectories in older adults in low-vision rehabilitation for macular disease.

Journal Article J Am Geriatr Soc · November 2012 OBJECTIVES: To examine whether performance on a brief memory test is related to functional outcomes in older individuals undergoing low-vision rehabilitation (LVR) for macular disease. DESIGN: Observational cohort study of individuals receiving outpatient ... Full text Link to item Cite

Association of attentional shift and reversal learning to functional deficits in geriatric depression.

Journal Article Int J Geriatr Psychiatry · November 2012 OBJECTIVE: The objective of this study is to examine the association between self-reported functional disability in depressed older adults and two types of executive function processes, attentional set shifting and reversal learning. METHODS: Participants ... Full text Link to item Cite

Treatment course with antidepressant therapy in late-life depression.

Journal Article Am J Psychiatry · November 2012 OBJECTIVE: In order to assess the effect of gray matter volumes and cortical thickness on antidepressant treatment response in late-life depression, the authors examined the relationship between brain regions identified a priori and Montgomery-Ã…sberg Depre ... Full text Link to item Cite

Latent class-derived subgroups of depressive symptoms in a community sample of older adults: the Cache County Study.

Journal Article Int J Geriatr Psychiatry · October 2012 OBJECTIVE: We sought to identify possible subgroups of elders that varied in depressive symptomatology and to examine symptom patterns and health status differences between subgroups. METHODS: The Cache County memory study is a population-based epidemiolog ... Full text Link to item Cite

Clinical and sociodemographic factors in a sample of older subjects experiencing depressive symptoms.

Journal Article Int J Geriatr Psychiatry · September 2012 OBJECTIVES: This study aims to determine the frequency of clinically significant depressive symptoms (CSDS) in a community sample of older Brazilians and to examine their relationship with sociodemographic factors, cognitive and functional impairment (CFI) ... Full text Link to item Cite

Neural correlates associated with cognitive decline in late-life depression.

Journal Article Am J Geriatr Psychiatry · August 2012 OBJECTIVES: Persistent cognitive impairment (PCI) after remission of depressive symptoms is a major adverse outcome of late-life depression (LLD). The purpose of this study was to examine neural substrates associated with PCI in LLD. DESIGN: Longitudinal s ... Full text Link to item Cite

Depression in Taiwanese patients with Alzheimer's disease determined by the National Institutes of Mental Health Provisional Criteria.

Journal Article Int Psychogeriatr · August 2012 BACKGROUND: Depression is a common behavioral and psychological symptom of Alzheimer's disease (AD). The aims of the present study were to determine the rate of depression in Taiwanese patients with AD using the National Institutes of Mental Health Provisi ... Full text Link to item Cite

Stressful life events, perceived stress, and 12-month course of geriatric depression: direct effects and moderation by the 5-HTTLPR and COMT Val158Met polymorphisms.

Journal Article Stress · July 2012 Although the relation between stressful life events (SLEs) and risk of major depressive disorder is well established, important questions remain about the effects of stress on the course of geriatric depression. Our objectives were (1) to examine how basel ... Full text Link to item Cite

Depressed older patients with the atypical features of interpersonal rejection sensitivity and reversed-vegetative symptoms are similar to younger atypical patients.

Journal Article Am J Geriatr Psychiatry · July 2012 OBJECTIVES: The atypical depression (AD) subtype has rarely been examined in older patients. However, younger AD patients have been characterized as having more severe and chronic symptoms of depression compared with non-AD patients. DESIGN: Secondary data ... Full text Link to item Cite

Impact of BDNF Val66Met and 5-HTTLPR polymorphism variants on neural substrates related to sadness and executive function.

Journal Article Genes Brain Behav · April 2012 The brain-derived neurotrophic factor (BDNF) Val(66) Met allelic variation is linked to both the occurrence of mood disorders and antidepressant response. These findings are not universally observed, and the mechanism by which this variation results in inc ... Full text Link to item Cite

Association of Five-Factor Model Personality Domains and Facets with Presence, Onset, and Treatment Outcomes of Major Depression in Older Adults.

Journal Article Am J Geriatr Psychiatry · March 15, 2012 OBJECTIVES:: To assess the relationship of multiple domains and facets of the five-factor model of personality with presence, onset, and severity of late-life depression. DESIGN:: Cross-sectional analysis of depression status, and age of onset. Retrospecti ... Full text Link to item Cite

Neuropsychological Predictors of Dementia in Late-Life Major Depressive Disorder.

Journal Article Am J Geriatr Psychiatry · March 11, 2012 OBJECTIVE:: Major depressive disorder is a likely risk factor for dementia, but some cases of major depressive disorder in older adults may actually represent a prodrome of this condition. The purpose of this study was to use neuropsychological test scores ... Full text Link to item Cite

Plasma omega-3 polyunsaturated fatty acids and survival in patients with chronic heart failure and major depressive disorder.

Journal Article J Cardiovasc Transl Res · February 2012 The omega-3 fatty acid (FA) concentration is low in patients with coronary heart disease (CHD). Supplement of omega-3 FA improves cardiovascular outcomes in patients with CHD and heart failure (HF). However, plasma omega-3 FA and its role for prognosis in ... Full text Link to item Cite

Religion and the presence and severity of depression in older adults.

Journal Article Am J Geriatr Psychiatry · February 2012 OBJECTIVES: : To examine the associations of dimensions of religiousness with the presence and severity of depression in older adults. DESIGN: : Cross-sectional analysis of clinical and interview data. SETTING: : Private university-affiliated medical cente ... Full text Link to item Cite

Depression, hippocampal volume changes, and cognitive decline in a clinical sample of older depressed outpatients and non-depressed controls.

Journal Article Aging Ment Health · 2012 OBJECTIVE: The aim of this study was to develop and test a model of depression, hippocampal changes, and cognitive decline. METHOD: Participants were 248 community-dwelling, depressed patients and 147 healthy, non-depressed individuals 60 years and older. ... Full text Link to item Cite

A functional alternative splicing mutation in human tryptophan hydroxylase-2.

Journal Article Mol Psychiatry · December 2011 The brain serotonergic system has an essential role in the physiological functions of the central nervous system and dysregulation of serotonin (5-HT) homeostasis has been implicated in many neuropsychiatric disorders. The tryptophan hydroxylase-2 (TPH2) g ... Full text Link to item Cite

Change in stress and social support as predictors of cognitive decline in older adults with and without depression.

Journal Article Int J Geriatr Psychiatry · December 2011 OBJECTIVE: The relationship between stress, social support, and cognition in geriatric depression is complex. In this study, we sought to examine whether an increase in stressful life events or a decrease in social support would lead to subsequent cognitiv ... Full text Link to item Cite

MRI-defined vascular depression: a review of the construct.

Journal Article Int J Geriatr Psychiatry · November 2011 OBJECTIVE: To review the construct of MRI-defined vascular depression and to examine the substantive and methodological issues that bear on its validity as a distinct subtype of depression in late life. DESIGN: Literature review. RESULTS: We identified thr ... Full text Link to item Cite

Early parental death and remarriage of widowed parents as risk factors for Alzheimer disease: the Cache County study.

Journal Article Am J Geriatr Psychiatry · September 2011 OBJECTIVES: Early parental death is associated with lifelong tendencies toward depression and chronic stress. We tested the hypothesis that early parental death is associated with higher risk for Alzheimer disease (AD) in offspring. DESIGN: A population-ba ... Full text Link to item Cite

Incidence of dementia and cognitive impairment, not dementia in the United States.

Journal Article Ann Neurol · September 2011 OBJECTIVE: Estimates of incident dementia, and cognitive impairment, not dementia (CIND) (or the related mild cognitive impairment) are important for public health and clinical care policy. In this paper, we report US national incidence rates for dementia ... Full text Link to item Cite

Amygdala volume in late-life depression: relationship with age of onset.

Journal Article Am J Geriatr Psychiatry · September 2011 OBJECTIVES: Depression is common in the elderly population. Although numerous neuroimaging studies have examined depressed elders, there is limited research examining how amygdala volume may be related to depression. DESIGN: A cross-sectional examination o ... Full text Link to item Cite

Heterogeneity in symptom profiles among older adults diagnosed with major depression.

Journal Article Int Psychogeriatr · August 2011 BACKGROUND: Late-life depression may be undiagnosed due to symptom expression. These analyses explore the structure of depressive symptoms in older patients diagnosed with major depression by identifying clusters of patients based on their symptom profiles ... Full text Link to item Cite

Reduction of dorsolateral prefrontal cortex gray matter in late-life depression.

Journal Article Psychiatry Res · July 30, 2011 Postmortem studies have documented abnormalities in the dorsolateral prefrontal cortex (dlPFC) in depressed subjects. In this study we used magnetic resonance imaging to test for dlPFC volume differences between older depressed and non-depressed individual ... Full text Link to item Cite

Efficacy and safety of adjunctive aripiprazole in major depressive disorder in older patients: a pooled subpopulation analysis.

Journal Article Int J Geriatr Psychiatry · June 2011 OBJECTIVES: To evaluate the efficacy and safety of adjunctive aripiprazole compared with standard antidepressant therapy (ADT) for older patients with major depressive disorder (MDD) who demonstrated an incomplete response to standard antidepressant monoth ... Full text Link to item Cite

Structural neuroimaging of geriatric depression.

Journal Article Psychiatr Clin North Am · June 2011 There is a large literature on the neuroanatomy of late-life depression that continues to grow with the discovery of novel structural imaging techniques along with innovative methods to analyze the images. Such advances have helped identify specific areas, ... Full text Link to item Cite

BDNF Val66Met genotype and 6-month remission rates in late-life depression.

Journal Article Pharmacogenomics J · April 2011 Although not observed in younger adult cohorts, in older individuals the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with major depressive disorder (MDD) risk. It is further associated with subjective social support and mag ... Full text Link to item Cite

Religious factors and hippocampal atrophy in late life.

Journal Article PLoS One · March 30, 2011 Despite a growing interest in the ways spiritual beliefs and practices are reflected in brain activity, there have been relatively few studies using neuroimaging data to assess potential relationships between religious factors and structural neuroanatomy. ... Full text Link to item Cite

Neuropsychiatric symptoms and the risk of institutionalization and death: the aging, demographics, and memory study.

Journal Article J Am Geriatr Soc · March 2011 OBJECTIVES: To examine the association between neuropsychiatric symptoms and risk of institutionalization and death. DESIGN: Analysis of longitudinal data. SETTING: The Aging, Demographics, and Memory Study (ADAMS). PARTICIPANTS: Five hundred thirty-seven ... Full text Link to item Cite

Social support modifies the relationship between personality and depressive symptoms in older adults.

Journal Article Am J Geriatr Psychiatry · February 2011 OBJECTIVE: To explore the relationship between personality, social support, and depression in older adults, identify the personality trait and social support dimension most closely associated with depression, and determine whether the relationship between ... Full text Link to item Cite

Comorbid cognitive impairment and functional trajectories in low vision rehabilitation for macular disease.

Journal Article Aging Clin Exp Res · 2011 BACKGROUND AND AIMS: Comorbid cognitive impairment is common among visually impaired older adults. This study investigated whether baseline cognitive status predicts functional trajectories among older adults in low vision rehabilitation (LVR) for macular ... Full text Link to item Cite

Change in hippocampal volume on magnetic resonance imaging and cognitive decline among older depressed and nondepressed subjects in the neurocognitive outcomes of depression in the elderly study.

Journal Article Am J Geriatr Psychiatry · January 2011 INTRODUCTION: previous studies have linked hippocampal volume change and cognitive decline in older adults with dementia. The authors examined hippocampal volume change and cognitive change in older nondemented adults with and without major depression. MET ... Full text Link to item Cite

Altered cerebellar-cerebral functional connectivity in geriatric depression.

Journal Article PLoS One · 2011 Although volumetric and activation changes in the cerebellum have frequently been reported in studies on major depression, its role in the neural mechanism of depression remains unclear. To understand how the cerebellum may relate to affective and cognitiv ... Full text Link to item Cite

Cross-cultural considerations in administering the center for epidemiologic studies depression scale.

Journal Article Gerontology · 2011 BACKGROUND: Cultural biases may affect the individual responses to questionnaires for depression and thus confound the international or multiethnic researches on depression. OBJECTIVE: We compared the diagnostic accuracy of the Center for Epidemiologic Stu ... Full text Link to item Cite

Structural integrity of the uncinate fasciculus and resting state functional connectivity of the ventral prefrontal cortex in late life depression.

Journal Article PLoS One · 2011 BACKGROUND: Neuroimaging studies in late life depression have reported decreased structural integrity of white matter tracts in the prefrontal cortex. Functional studies have identified changes in functional connectivity among several key areas involved in ... Full text Link to item Cite

The moderating effect of the APOE [small element of] 4 allele on the relationship between hippocampal volume and cognitive decline in older depressed patients.

Journal Article Am J Geriatr Psychiatry · January 2011 OBJECTIVE: the apolipoprotein E epsilon-4 (APOE [small element of] 4) allele and depression are independently associated with increased risk for cognitive decline (CD). The authors have reported that depressed elders with an APOE [small element of]4 allele ... Full text Link to item Cite

Associations of religious behavior and experiences with extent of regional atrophy in the orbitofrontal cortex during older adulthood.

Journal Article Religion Brain Behav · 2011 The orbitofrontal cortex (OFC) is a region of the brain that has been empirically linked with religious or spiritual activity, and atrophy in this region has been shown to contribute to serious mental illness in late life. This study used structural magnet ... Full text Link to item Cite

Acute Management of Late-Life Depression

Chapter · December 2, 2010 The patient with late-life depression frequently presents in a complex manner that may require hospitalization. Accurate diagnosis and treatment of these patients is essential to prevent disability, caregiver burden and nursing home placement. Confusion, s ... Full text Cite

Adherence to treatment for depression

Chapter · December 1, 2010 Major depressive disorder (MDD) is often a chronic, recurrent, and debilitating health problem with a lifetime prevalence of 16.2% and a 12-month prevalence of 6.6% in the USA [1]. Left untreated, depression can have a significant negative impact on a pers ... Full text Cite

Variability in frontotemporal brain structure: the importance of recruitment of African Americans in neuroscience research.

Journal Article PLoS One · October 26, 2010 BACKGROUND: Variation in brain structure is both genetically and environmentally influenced. The question about potential differences in brain anatomy across populations of differing race and ethnicity remains a controversial issue. There are few studies s ... Full text Open Access Link to item Cite

Accurate identification of MCI patients via enriched white-matter connectivity network

Journal Article Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · October 25, 2010 Mild cognitive impairment (MCI), often a prodromal phase of Alzheimer's disease (AD), is frequently considered to be a good target for early diagnosis and therapeutic interventions of AD. Recent emergence of reliable network characterization techniques hav ... Full text Cite

Quetiapine XR: current status for the treatment of major depressive disorder.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · October 1, 2010 Quetiapine fumarate extended release (XR) has been approved for treatment of schizophrenia and bipolar disorder. Quetiapine may have antidepressant effects through effects on 5-HT(2A) receptor, 5-HT(1A) receptor, dopamine receptor, glutamate receptor and n ... Full text Link to item Cite

Cerebrovascular risk factors and cerebral hyperintensities among middle-aged and older adults with major depression.

Journal Article Am J Geriatr Psychiatry · September 2010 OBJECTIVES: To examine the association between cerebral hyperintensities and cerebrovascular risk factors (CVRF) among middle-aged and older adults with major depressive disorder (MDD). METHODS: Thirty patients (aged 55-77 years) with MDD and no history of ... Full text Link to item Cite

Differential patterns of cognitive decline in anterior and posterior white matter hyperintensity progression.

Journal Article Stroke · September 2010 BACKGROUND AND PURPOSE: White matter hyperintensities (WMHs) found on brain MRI in elderly individuals are largely thought to be due to microvascular disease, and its progression has been associated with cognitive decline. The present study sought to deter ... Full text Link to item Cite

Functional evidence implicating a novel TOR1A mutation in idiopathic, late-onset focal dystonia.

Journal Article J Med Genet · September 2010 BACKGROUND: TOR1A encodes a chaperone-like AAA-ATPase whose Delta GAG (Delta E) mutation is responsible for an early onset, generalised dystonia syndrome. Because of the established role of the TOR1A gene in heritable generalised dystonia (DYT1), a potenti ... Full text Link to item Cite

Angiotensin receptor gene polymorphisms and 2-year change in hyperintense lesion volume in men.

Journal Article Mol Psychiatry · August 2010 This longitudinal study examined the relationship between 2-year change in white matter hyperintense lesion (WML) volume and polymorphisms in genes coding for the angiotensin-II type 1 and type 2 receptors, AGTR1 A1166C and AGTR2 C3123A, respectively. 137 ... Full text Link to item Cite

Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects.

Journal Article Biochim Biophys Acta · August 2010 The neurosteroid allopregnanolone has pronounced neuroprotective actions, increases myelination, and enhances neurogenesis. Evidence suggests that allopregnanolone dysregulation may play a role in the pathophysiology of Alzheimer's disease (AD) and other n ... Full text Link to item Cite

Depressive morbidity and gender in community-dwelling Brazilian elderly: systematic review and meta-analysis.

Journal Article Int Psychogeriatr · August 2010 BACKGROUND: Although studies indicate that community-dwelling elderly have a lower prevalence of major depression compared with younger age groups, prevalence estimates in Brazil show that clinically significant depressive symptoms (CSDS) and depression ar ... Full text Link to item Cite

Metabolomic differences in heart failure patients with and without major depression.

Journal Article J Geriatr Psychiatry Neurol · June 2010 Metabolomics is an emerging technology that allows researchers to characterize hundreds of small molecules that comprise the metabolome. We sought to determine metabolic differences in depressed and nondepressed participants. The sample consisted of a depr ... Full text Link to item Cite

White matter hyperintensities and their association with suicidality in major affective disorders: a meta-analysis of magnetic resonance imaging studies.

Journal Article CNS Spectr · June 2010 INTRODUCTION: Individuals who have deep and periventricular white matter hyperintensities may have a higher risk for suicidal behavior. There are mixed results in the literature regarding whether unipolar or bipolar patients who have attempted suicide have ... Full text Link to item Cite

Greater risk of dementia when spouse has dementia? The Cache County study.

Journal Article J Am Geriatr Soc · May 2010 OBJECTIVES: To examine the effects of caring for a spouse with dementia on the caregiver's risk for incident dementia. DESIGN: Population-based study of incident dementia in spouses of persons with dementia. SETTING: Rural county in northern Utah. PARTICIP ... Full text Link to item Cite

The brain-derived neurotrophic factor Val66Met polymorphism, hippocampal volume, and cognitive function in geriatric depression.

Journal Article Am J Geriatr Psychiatry · April 2010 OBJECTIVE: The Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene is associated with geriatric depression. In studies of younger adults without depression, met allele carriers exhibit smaller hippocampal volumes and have poorer perf ... Full text Link to item Cite

Cholinesterase inhibitors as adjunctive therapy in patients with schizophrenia and schizoaffective disorder: a review and meta-analysis of the literature.

Journal Article CNS Drugs · April 2010 BACKGROUND: Cognitive deficits have been described in patients with schizophrenia from the first descriptions of dementia praecox to current concepts of cognitive dysmetria. Nevertheless, little is known about how to deal with them. In Alzheimer disease, c ... Full text Link to item Cite

Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial.

Journal Article Arch Gen Psychiatry · March 2010 CONTEXT: Research on vascular depression has used 2 approaches to subtype late-life depression, based on executive dysfunction or white matter hyperintensity severity. OBJECTIVE: To evaluate the relationship of neuropsychological performance and white matt ... Full text Link to item Cite

Prevalence of neuropsychiatric symptoms and their association with functional limitations in older adults in the United States: the aging, demographics, and memory study.

Journal Article J Am Geriatr Soc · February 2010 OBJECTIVES: To estimate the prevalence of neuropsychiatric symptoms and examine their association with functional limitations. DESIGN: Cross-sectional analysis. SETTING: The Aging, Demographics, and Memory Study (ADAMS). PARTICIPANTS: A sample of adults ag ... Full text Link to item Cite

Prevalence and patterns of comorbid cognitive impairment in low vision rehabilitation for macular disease.

Journal Article Arch Gerontol Geriatr · 2010 The prevalence of comorbid cognitive impairment among older adults referred to low vision rehabilitation (LVR) for macular disease is unknown. We performed cognitive testing on 101 adults aged 65 years or older with macular disease who were referred to The ... Full text Link to item Cite

Trajectories of mobility and IADL function in older patients diagnosed with major depression.

Journal Article Int J Geriatr Psychiatry · January 2010 OBJECTIVE: Research has shown an association between depression and functional limitations in older adults. Our aim was to explore the latent traits of trajectories of limitations in mobility and instrumental activities of daily living (IADL) tasks in a sa ... Full text Link to item Cite

Geriatric Psychiatry

Journal Article Psychiatric Annals · January 1, 2010 Full text Cite

Understanding depression and cognitive impairment in the elderly

Journal Article Psychiatric Annals · January 1, 2010 Full text Cite

Cognitive performance and informant reports in the diagnosis of cognitive impairment and dementia in African Americans and whites.

Journal Article Alzheimers Dement · November 2009 BACKGROUND: The diagnosis of cognitive impairment and dementia must reflect an increasingly diverse and aging United States population. This study compared direct testing and informant reports of cognition with clinical diagnoses of cognitive impairment an ... Full text Link to item Cite

A multiplicity of approaches to characterize geriatric depression and its outcomes.

Journal Article Curr Opin Psychiatry · November 2009 PURPOSE OF REVIEW: Research in geriatric depression has always had a multidisciplinary bent, particularly in methods used to characterize depression. Understanding diagnosis, psychiatric comorbidities, and course continues to be a goal of clinical research ... Full text Link to item Cite

Natural food folate and late-life depression.

Journal Article J Nutr Elder · October 2009 Low folate status has been linked to depression, but findings have been inconsistent. The authors sought to examine the association between folate intake and late-life depression. This cross-sectional study included individuals age 60 and older (n = 111 de ... Full text Link to item Cite

Influence of the MTHFR C677T polymorphism on magnetic resonance imaging hyperintensity volume and cognition in geriatric depression.

Journal Article Am J Geriatr Psychiatry · October 2009 OBJECTIVE: The 5,10-methylenetetrahydrofolate reductase gene (MTHFR) has been linked to unipolar major depressive disorder (MDD) and magnetic resonance imaging (MRI) hyperintensities. The authors examined the relationship between the MTHFR C677T polymorphi ... Full text Link to item Cite

Prevalence of depression among older Americans: the Aging, Demographics and Memory Study.

Journal Article Int Psychogeriatr · October 2009 BACKGROUND: Previous studies have attempted to provide estimates of depression prevalence in older adults. The Aging, Demographics and Memory Study (ADAMS) is a population-representative study that included a depression assessment, providing an opportunity ... Full text Link to item Cite

The COMT Val158Met polymorphism and cognition in depressed and nondepressed older adults.

Journal Article Int J Geriatr Psychiatry · October 2009 OBJECTIVE: The objective of the current study was to examine the relationship between the COMT Val(158)Met polymorphism and neuropsychological performance in depressed and nondepressed older adults. METHODS: One hundred and twenty-six clinically depressed ... Full text Link to item Cite

The moderating role of personality factors in the relationship between depression and neuropsychological functioning among older adults.

Journal Article Int J Geriatr Psychiatry · September 2009 OBJECTIVE: Depression is often associated with decreased cognitive performance among older adults. The current study focused on the association of neuropsychological functioning and personality traits in depressed and non-depressed older adults. METHODS: D ... Full text Link to item Cite

Association analysis of the COMT/MTHFR genes and geriatric depression: an MRI study of the putamen.

Journal Article Int J Geriatr Psychiatry · August 2009 OBJECTIVE: Catechol-O-Methyltransferase (COMT) and Methylenetetrahydrofolate reductase (MTHFR) had been reported to relate to depression but with inconsistent results. The basal ganglia are also important in the pathophysiology of affective disorder via co ... Full text Link to item Cite

Reductions in neuronal density in elderly depressed are region specific.

Journal Article Int J Geriatr Psychiatry · August 2009 OBJECTIVE: Frontal regions, including the orbitofrontal cortex (ORB) and dorsolateral prefrontal cortex (dlPFC) have been implicated in the neuropathology of geriatric depression. Prominent reductions in pyramidal neuron density have been recently reported ... Full text Link to item Cite

Clinically significant depressive symptoms and associated factors in community elderly subjects from Sao Paulo, Brazil.

Journal Article Am J Geriatr Psychiatry · July 2009 OBJECTIVES: To determine the frequency of clinically significant depressive symptoms (CSDS) in a community sample of Brazilian elderly and to assess their relationship with sociodemographic factors, cognitive and functional impairment (CFI), and clinical d ... Full text Link to item Cite

Thyroid hormones affect recovery from depression during antidepressant treatment.

Journal Article Psychiatry Clin Neurosci · June 2009 AIMS: The aim of the present study was to evaluate whether thyroid hormonal changes during menopause may affect the development and the course of major depressive disorder. METHODS: Thirty-nine female patients (n = 17 in pre-menopause; n = 22 in post-menop ... Full text Link to item Cite

Twin pairs discordant for neuropathologically confirmed Lewy body dementia.

Journal Article J Neurol Neurosurg Psychiatry · May 2009 AIM: Little is known about the concordance rate in twins for dementia with Lewy bodies (DLB). The rate of agreement between clinical and pathological diagnoses for DLB is typically low, necessitating confirmation of the diagnosis neuropathologically. METHO ... Full text Link to item Cite

Profiles of depressive symptoms in older adults diagnosed with major depression: latent cluster analysis.

Journal Article Am J Geriatr Psychiatry · May 2009 OBJECTIVE: To explore the underlying structure of symptom presentation in older adults with major depression by identifying homogeneous clusters of individuals based on symptom profiles. DESIGN: Secondary data analysis using latent class cluster analysis. ... Full text Link to item Cite

Biochemical abnormalities of the medial temporal lobe and medial prefrontal cortex in late-life depression.

Journal Article Psychiatry Res · April 30, 2009 We utilized single-voxel (1)H magnetic resonance spectroscopy (MRS) to investigate biochemical abnormalities related to late-life depression in the medial prefrontal cortex and medial temporal lobe. Fourteen elderly subjects whose depression responded to t ... Full text Link to item Cite

Effectiveness of antidepressant treatments in pre-menopausal versus post-menopausal women: a pilot study on differential effects of sex hormones on antidepressant effects.

Journal Article Biomed Pharmacother · March 2009 The incidence or recurrence of major depression is greatly increased in women during the transition to and after menopause and hormonal changes occurring during these periods are thought to play an important role in depressive recurrence. It has been also ... Full text Link to item Cite

Neuropsychological correlates of magnetic resonance imaging-defined subcortical ischemic depression.

Journal Article Int J Geriatr Psychiatry · March 2009 OBJECTIVE: The goal of the current study was to examine the neuropsychological profile of magnetic resonance imaging (MRI)-defined subcortical ischemic depression (SID). METHODS: Clinically depressed older adults with MRI-defined SID (n = 70) and depressed ... Full text Link to item Cite

Outcomes of older cognitively impaired individuals with current and past depression in the NCODE study.

Journal Article J Geriatr Psychiatry Neurol · March 2009 We examined the frequency and course of cognitive impairment, no dementia among a group of older patients enrolled in a longitudinal study of depression. Among 230 participants, 29 with baseline dementia diagnosis were excluded from further analyses. Among ... Full text Link to item Cite

APOE related hippocampal shape alteration in geriatric depression.

Journal Article Neuroimage · February 1, 2009 Late-onset depression often precedes the onset of dementia associated with the hippocampal degeneration. Using large deformation diffeomorphic metric mapping (LDDMM), we evaluated apolipoprotein E epsilon-4 allele (apoE E4) effects on hippocampal volume an ... Full text Link to item Cite

Glycemic index and glycemic load are not associated with brain lesions in the elderly.

Journal Article J Nutr Health Aging · February 2009 OBJECTIVE: The goal of this study was to determine if brain lesion volume was correlated with dietary glycemic index and glycemic load in elderly individuals. DESIGN AND SETTING: This cross-sectional study was performed at an academic medical center as par ... Full text Link to item Cite

Course of suicide ideation and predictors of change in depressed older adults.

Journal Article J Affect Disord · February 2009 BACKGROUND: Rates of suicide among older adults in the United States are higher than that of other age groups. Therefore, it is critically important to deepen understanding of the processes that drive suicide risk among at-risk older patients. To this end, ... Full text Link to item Cite

Does neurotropin-3 have a therapeutic implication in major depression?

Journal Article Int J Neurosci · November 2008 Although several classes of antidepressants are used to treat major depression, there is an unmet need in real clinical practice because not all patients treated with an antidepressant fully recover from their functional impairment. Hence, the development ... Full text Link to item Cite

Social support in older individuals: the role of the BDNF Val66Met polymorphism.

Journal Article Am J Med Genet B Neuropsychiatr Genet · October 5, 2008 Although often viewed as a purely environmental construct, perception of social support may be influenced by genetic factors. This study examined the relationship between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and social support ... Full text Link to item Cite

The vascular depression subtype: evidence of internal validity.

Journal Article Biol Psychiatry · September 15, 2008 BACKGROUND: Vascular depression has been proposed as a unique diagnostic subtype in late life, yet no study has evaluated whether the specified clinical features associated with the illness are jointly indicative of an underlying diagnostic class. METHODS: ... Full text Link to item Cite

Midlife activity predicts risk of dementia in older male twin pairs.

Journal Article Alzheimers Dement · September 2008 BACKGROUND: This was a prospective study of dementia to elucidate mechanisms of disease risk factors amenable to modification and specifically to determine whether midlife cognitive and physical leisure activities are associated with delayed onset or reduc ... Full text Link to item Cite

Neurocognitive correlates of response to treatment in late-life depression.

Journal Article Am J Geriatr Psychiatry · September 2008 UNLABELLED: Depression is often associated with neurocognitive deficits in older adults, particularly in the domains of information processing speed, episodic memory, and executive functions. Greater neurocognitive dysfunction while depressed is associated ... Full text Link to item Cite

Cerebrospinal fluid dehydroepiandrosterone levels are correlated with brain dehydroepiandrosterone levels, elevated in Alzheimer's disease, and related to neuropathological disease stage.

Journal Article J Clin Endocrinol Metab · August 2008 OBJECTIVE: It is currently unknown whether cerebrospinal fluid (CSF) neurosteroid levels are related to brain neurosteroid levels in humans. CSF and brain dehydroepiandrosterone (DHEA) levels are elevated in patients with Alzheimer's disease (AD), but it i ... Full text Link to item Cite

Do estradiol levels influence on the cognitive function during antidepressant treatments in post-menopausal women with major depressive disorder? A comparison with pre-menopausal women.

Journal Article Neuro Endocrinol Lett · August 2008 OBJECTIVES: A hypo-estrogenic status, as that occurring with menopause, has been proposed to negatively affect cognitive function in post-menopause women. Nevertheless, little is known about the improvement of cognitive functions during antidepressant trea ... Link to item Cite

Separating mood disturbance from mild cognitive impairment in geriatric depression.

Journal Article Int Rev Psychiatry · August 2008 Disentangling depression from dementia remains one of the most difficult clinical challenges for psychiatrists caring for older adults. The relationship between geriatric depression and dementia is complex for several reasons. First, cognitive impairment i ... Full text Link to item Cite

Hippocampal volumes and depression subtypes.

Journal Article Psychiatry Res · July 15, 2008 Studies of depression and hippocampal volume have yielded inconsistent results. This inconsistency could stem from the heterogeneity of depressive disorders. We conducted cross-sectional and longitudinal analyses of hippocampal volumes in atypical depressi ... Full text Link to item Cite

Depressive state- and disease-related alterations in neural responses to affective and executive challenges in geriatric depression.

Journal Article Am J Psychiatry · July 2008 OBJECTIVE: Geriatric depression has been associated with a heterogeneous neuropathology. Identifying both depressive state-related and disease-related alterations in brain regions associated with emotion and cognitive function could provide useful diagnost ... Full text Link to item Cite

Age-dependent reduction of amygdala volume in bipolar disorder.

Journal Article Psychiatry Res · May 30, 2008 The amygdala is hypothesized to play a critical role in mood regulation, yet its involvement in bipolar disorder remains unclear. The aim of the present study was to compare measurements of amygdala volumes in a relatively large sample of bipolar disorder ... Full text Link to item Cite

Calcium and vitamin D intakes may be positively associated with brain lesions in depressed and nondepressed elders.

Journal Article Nutr Res · May 2008 Studies indicate that diet and vascular calcification may be related to the occurrence of brain lesions, although the importance of dietary calcium and vitamin D has not been investigated. The objective of this study was to test the hypothesis that calcium ... Full text Link to item Cite

Church attendance and new episodes of major depression in a community study of older adults: the Cache County Study.

Journal Article J Gerontol B Psychol Sci Soc Sci · May 2008 We examined the relation between church attendance, membership in the Church of Jesus Christ of Latter-Day Saints (LDS), and major depressive episode, in a population-based study of aging and dementia in Cache County, Utah. Participants included 2,989 nond ... Full text Link to item Cite

Amyloid-associated depression: a prodromal depression of Alzheimer disease?

Journal Article Arch Gen Psychiatry · May 2008 CONTEXT: A high ratio of plasma amyloid-beta peptide 40 (Abeta(40)) to Abeta(42), determined by both high Abeta(40) and low Abeta(42) levels, increases the risk of Alzheimer disease. In a previous study, we reported that depression is also associated with ... Full text Link to item Cite

The brain-derived neurotrophic factor VAL66MET polymorphism and cerebral white matter hyperintensities in late-life depression.

Journal Article Am J Geriatr Psychiatry · April 2008 OBJECTIVE: In animal models, brain-derived neurotrophic factor (BDNF) appears to protect against cerebral ischemia. The authors examined whether the BDNF Val66Met polymorphism, which affects BDNF distribution, was associated with greater volumes of hyperin ... Full text Link to item Cite

The course of depressive symptoms in older adults with comorbid major depression and dysthymia.

Journal Article Am J Geriatr Psychiatry · April 2008 OBJECTIVE: To examine the course of depressive symptoms in older patients with comorbid major depression and dysthymia. DESIGN: Secondary data analysis using both proportional hazards modeling and a repeated measures mixed model. SETTING: Clinical Research ... Full text Link to item Cite

Hippocampus shape analysis and late-life depression.

Journal Article PLoS One · March 19, 2008 Major depression in the elderly is associated with brain structural changes and vascular lesions. Changes in the subcortical regions of the limbic system have also been noted. Studies examining hippocampus volumetric differences in depression have shown va ... Full text Open Access Link to item Cite

Prevalence of cognitive impairment without dementia in the United States.

Journal Article Ann Intern Med · March 18, 2008 BACKGROUND: Cognitive impairment without dementia is associated with increased risk for disability, increased health care costs, and progression to dementia. There are no population-based prevalence estimates of this condition in the United States. OBJECTI ... Full text Link to item Cite

Antidepressant treatment and worsening white matter on serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health Study.

Journal Article Stroke · March 2008 BACKGROUND AND PURPOSE: In some studies, late life depression is associated with white matter lesions on MRI. The effect of different classes of antidepressants on progression of white matter lesions is unknown. Selective serotonergic reuptake inhibitors ( ... Full text Link to item Cite

Short/long heterozygotes at 5HTTLPR and white matter lesions in geriatric depression.

Journal Article Int J Geriatr Psychiatry · March 2008 OBJECTIVE: We examined the relationship between 5HTTLPR genotype and volume of magnetic resonance imaging (MRI) brain lesions. METHOD: We studied 217 older depressed patients and 141 individuals in the comparison group using a standard brain MRI protocol t ... Full text Link to item Cite

Is there protective haplotype of dysbindin gene (DTNBP1) 3 polymorphisms for major depressive disorder.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · February 15, 2008 Dysbindin gene has been repeatedly associated with psychiatric disorders and schizophrenia in particular. This study aimed to investigate the variants of dysbindin gene in major depressive disorder (MDD). One hundred and eighty eight patients with MDD and ... Full text Link to item Cite

Aging, gender, and the elderly adult brain: an examination of analytical strategies.

Journal Article Neurobiol Aging · February 2008 We sought to examine the relations between age, gender and brain volumes in an elderly population; we also sought to examine ways of measuring these relations. Three sets of analyses were used: correlational analyses, in which correlations between independ ... Full text Link to item Cite

The effects of antidepressant medication adherence as well as psychosocial and clinical factors on depression outcome among older adults.

Journal Article Int J Geriatr Psychiatry · February 2008 OBJECTIVE: To examine the contribution of medication adherence to 12-month depression scores in the context of other psychosocial and clinical predictors of depression in a sample of older adults treated for depression. METHODS: Secondary analysis of a pro ... Full text Link to item Cite

Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study.

Journal Article Int J Geriatr Psychiatry · February 2008 BACKGROUND: Neuropsychiatric symptoms are nearly universal in dementia, yet little is known about their longitudinal course in the community. OBJECTIVE: To estimate point and 5-year period prevalence of neuropsychiatric symptoms in an incident sample of 40 ... Full text Link to item Cite

Geriatric depression and cognitive impairment.

Journal Article Psychol Med · February 2008 Cognitive impairment is common in geriatric depression, and depressed individuals with co-morbid cognitive impairment are at increased risk for a number of adverse medical, psychiatric and cognitive outcomes. This review focuses on clinical issues surround ... Full text Link to item Cite

Validation of the Patient Health Questionnaire-9 Korean version in the elderly population: the Ansan Geriatric study.

Journal Article Compr Psychiatry · 2008 OBJECTIVE: We evaluated the diagnostic validity of the 9-item depression module of the Patient Health Questionnaire-9 (PHQ-9) in elderly Korean patients and suggest an optimal cutoff score to screen for major depressive disorders. METHOD: The PHQ-9 and an ... Full text Link to item Cite

Review of evidence for genetic testing for CYP450 polymorphisms in management of patients with nonpsychotic depression with selective serotonin reuptake inhibitors.

Journal Article Genet Med · December 2007 PURPOSE: Cytochrome P450 (CYP450) enzymes metabolize selective serotonin reuptake inhibitor (SSRI) drugs used in treatment of depression. Variants in these genes may impact treatment efficacy and tolerability. The purpose of this study was 2-fold: to syste ... Full text Link to item Cite

Orbitofrontal cortex volume in late life depression: influence of hyperintense lesions and genetic polymorphisms.

Journal Article Psychol Med · December 2007 BACKGROUND: Orbitofrontal cortex (OFC) volumetric differences have been reported in depression, but in relatively small samples. Factors associated with these differences are not well described. We examined OFC volumes in a large sample of elderly depresse ... Full text Link to item Cite

Five-year trajectories of social networks and social support in older adults with major depression.

Journal Article Int Psychogeriatr · December 2007 BACKGROUND: Research with nondepressed adults suggests that social networks and social support are stable over the life course until very late age. This may not hold true for older adults with depression. We examined baseline status and trajectories of soc ... Full text Link to item Cite

Depression and cognitive impairment in older adults

Journal Article Psychiatric Times · November 1, 2007 Cite

Longitudinal magnetic resonance imaging vascular changes, apolipoprotein E genotype, and development of dementia in the neurocognitive outcomes of depression in the elderly study.

Journal Article Am J Geriatr Psychiatry · October 2007 OBJECTIVE: Several studies suggest that depression is a risk factor for development of dementia in the elderly. In a study of older depressed individuals, the authors examined both neuroimaging and genetic factors in development of dementia. The authors hy ... Full text Link to item Cite

Fatigue as a core symptom in major depressive disorder: overview and the role of bupropion.

Journal Article Expert Rev Neurother · October 2007 Fatigue is one of the most common symptoms found in both community and medical care settings. Fatigue may imply a prodromal or residual symptom of major depressive disorder or an adverse reaction to antidepressant treatment. Fatigue may also compromise ant ... Full text Link to item Cite

Prefrontal white matter lesions and prefrontal task impersistence in depressed and nondepressed elders.

Journal Article Neuropsychopharmacology · October 2007 Poor task persistence is often observed among depressed individuals, and may be associated with some of the same frontal regions that are involved in depression. The current study explored the association between white-matter lesion volume in prefrontal co ... Full text Link to item Cite

Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression.

Journal Article Am J Geriatr Psychiatry · October 2007 OBJECTIVE: The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with cognitive and neuroimaging changes. The authors examined the relationship between this polymorphism and depression in an elderly sample, hypothesizing tha ... Full text Link to item Cite

Autopsy-confirmed Alzheimer's disease versus clinically diagnosed Alzheimer's disease in the Cache County Study on Memory and Aging: a comparison of quantitative MRI and neuropsychological findings.

Journal Article J Clin Exp Neuropsychol · July 2007 Atrophy of specific, regional, and generalized brain structures occurs as a result of the Alzheimer's disease (AD) process. Comparing AD patients with histopathological confirmation of the disease at autopsy to those without autopsy but who were clinically ... Full text Link to item Cite

Association of AGTR1 with 18-month treatment outcome in late-life depression.

Journal Article Am J Geriatr Psychiatry · July 2007 OBJECTIVE: Converging lines of evidence implicate vascular factors in late-life depression, and argue that late-life depression is a distinct entity among the mood disorders. The A1166C polymorphism in the angiotensin II receptor, vascular type 1 (AGTR1) g ... Full text Link to item Cite

Job demands and dementia risk among male twin pairs.

Journal Article Alzheimers Dement · July 2007 BACKGROUND: Job characteristics may influence dementia risk, but some types of job complexity remain to be examined. Twin studies provide a useful methodology to examine job differences between pairs who share many environmental and genetic influences. MET ... Full text Link to item Cite

Widespread effects of hyperintense lesions on cerebral white matter structure.

Journal Article AJR Am J Roentgenol · June 2007 OBJECTIVE: Hyperintense lesions are a common finding on neuroimaging and are associated not only with aging, medical illness, and some invasive medical procedures, but also with neurologic and psychiatric morbidity. We hypothesized that hyperintense lesion ... Full text Link to item Cite

A preliminary metabolomic analysis of older adults with and without depression.

Journal Article Int J Geriatr Psychiatry · May 2007 BACKGROUND: Metabolomics, the global science of biochemistry, is an emerging field that enables detection and quantification of small molecules involved in metabolic and signaling pathways. Metabolic signatures for disease and its treatment could provide v ... Full text Link to item Cite

Reply from the authors [5]

Journal Article Neurology · May 1, 2007 Full text Cite

Contribution of depression to cognitive impairment and dementia in older adults.

Journal Article Neurologist · May 2007 BACKGROUND: The objective of this review is to provide information for clinicians regarding current research and opinions on the association of depression to conditions of cognitive impairment and dementia. We also intend to integrate this current research ... Full text Link to item Cite

Food group intake and brain lesions in late-life vascular depression.

Journal Article Int Psychogeriatr · April 2007 BACKGROUND: Studies indicate that diet may be related to the occurrence of brain lesions. The cross-sectional association between food intake and brain lesion volumes in late-life depression was examined in a cohort of elderly individuals with current or p ... Full text Link to item Cite

Are microvascular abnormalities in the retina associated with depression symptoms? The Cardiovascular Health Study.

Journal Article Am J Geriatr Psychiatry · April 2007 OBJECTIVE: Depression has been linked with vascular risk factors and stroke. The authors examined the relationship between retinal microvascular abnormalities and depression symptoms in an elderly population. METHODS: The Cardiovascular Health Study is a p ... Full text Link to item Cite

Persistent mild cognitive impairment in geriatric depression.

Journal Article Int Psychogeriatr · February 2007 BACKGROUND: Cognitive impairment often occurs with geriatric depression and impairments may persist despite remission of depression. Although clinical definitions of mild cognitive impairment (MCI) have typically excluded depression, a neuropsychological m ... Full text Link to item Cite

Satisfaction and outcomes of depressed older adults with psychiatric clinical nurse specialists in primary care

Journal Article Journal of the American Psychiatric Nurses Association · February 1, 2007 Background: Recent models integrating depression care management into primary care have demonstrated improved clinical outcomes and patient satisfaction. To date, none have examined psychiatric-mental health clinical nurse specialists (PCNSs) as providers ... Full text Cite

Symptomatic Remission in Patients with Bipolar Mania: Results from a Double-Blind, Placebo-Controlled Trial of Risperidone Monotherapy

Journal Article Progress in Neurotherapeutics and Neuropsychopharmacology · January 1, 2007 The purpose of this analysis was to compare symptomatic remission rates between risperidone and placebo in a completed randomized controlled trial. Design and Methods: Two hundred ninety (290) adult patients who met DSM-IV criteria for Bipolar I Disorder M ... Full text Cite

Testing for cytochrome P450 polymorphisms in adults with non-psychotic depression treated with selective serotonin reuptake inhibitors (SSRIs).

Journal Article Evid Rep Technol Assess (Full Rep) · January 2007 OBJECTIVES: To determine if testing for cytochrome P450 (CYP450) polymorphisms in adults entering selective serotonin reuptake inhibitor (SSRI) treatment for non-psychotic depression leads to improvement in outcomes, or if testing results are useful in med ... Link to item Cite

Prevalence of dementia in the United States: the aging, demographics, and memory study.

Journal Article Neuroepidemiology · 2007 AIM: To estimate the prevalence of Alzheimer's disease (AD) and other dementias in the USA using a nationally representative sample. METHODS: The Aging, Demographics, and Memory Study sample was composed of 856 individuals aged 71 years and older from the ... Full text Link to item Cite

Depressive symptoms and age-related macular degeneration in older people: the cardiovascular health study.

Journal Article Ophthalmic Epidemiol · 2007 PURPOSE: To examine the association between age-related macular degeneration (AMD) and depressive symptoms. METHODS: Population-based, cross-sectional study. A total of 2,194 persons aged 69-97 years were included in the current analyses. During the 1997-1 ... Full text Link to item Cite

Coenzyme Q10: a review of its promise as a neuroprotectant.

Journal Article CNS Spectr · January 2007 Coenzyme Q10 (CoQ10) is a powerful antioxidant that buffers the potential adverse consequences of free radicals produced during oxidative phosphorylation in the inner mitochondrial membrane. Oxidative stress, resulting in glutathione loss and oxidative DNA ... Full text Link to item Cite

Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression.

Journal Article Biol Psychiatry · December 15, 2006 BACKGROUND: The dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) are critical for mood regulation. Alterations in the white matter connections of these regions may impair their role in mood regulation and increase the risk of deve ... Full text Link to item Cite

The neurosteroid allopregnanolone is reduced in prefrontal cortex in Alzheimer's disease.

Journal Article Biol Psychiatry · December 15, 2006 BACKGROUND: Few data are currently available investigating neurosteroids (NS) in Alzheimer's disease (AD). The NS allopregnanolone may be decreased in serum and plasma in patients with AD, but it is unclear if allopregnanolone is also reduced in brain. Bec ... Full text Link to item Cite

Psychiatric disease in the twenty-first century: The case for subcortical ischemic depression.

Journal Article Biol Psychiatry · December 15, 2006 The current approach to psychiatric diagnoses involves identifying symptom clusters that fit a specific syndrome. Although this approach has facilitated the field's development, advances in genetics and neuroimaging raise the question of how causality may ... Full text Link to item Cite

Duke Twins Study of Memory in Aging in the NAS-NRC Twin Registry.

Journal Article Twin Res Hum Genet · December 2006 The Duke Twins Study of Memory in Aging is an ongoing, longitudinal study of cognitive change and dementia in the population-based National Academy of Sciences-National Research Council (NAS-NRC) Twin Registry of World War II Male Veterans. The primary goa ... Full text Link to item Cite

White matter lesion volumes and caudate volumes in late-life depression.

Journal Article Int J Geriatr Psychiatry · December 2006 BACKGROUND: Decreased caudate volumes and increased white matter lesions (WMLs) are associated both with aging and late-life depression, but the relationship between the two is unclear. We examined the association between WML and caudate volume, hypothesiz ... Full text Link to item Cite

Vascular risk factors and cognitive decline among elderly male twins.

Journal Article Neurology · November 14, 2006 BACKGROUND: Studies investigating the association between cardiovascular risk factors and cognitive decline report discrepant outcomes. The co-twin control method improves on traditional case-control approaches by controlling for within-twin pair similarit ... Full text Link to item Cite

Differences in brain volumes among males and female hormone-therapy users and nonusers.

Journal Article Psychiatry Res · October 30, 2006 Numerous studies have shown gender differences in the brain volumes of elderly adults. Some evidence shows that higher estrogen levels may be neuroprotective, suggesting that hormone therapy (HT) may in part be responsible for these gender differences; how ... Full text Link to item Cite

Reducing suicidal ideation in depressed older primary care patients.

Journal Article J Am Geriatr Soc · October 2006 OBJECTIVES: To determine the effect of a primary care-based collaborative care program for depression on suicidal ideation in older adults. DESIGN: Randomized, controlled trial. SETTING: Eighteen diverse primary care clinics. PARTICIPANTS: One thousand eig ... Full text Link to item Cite

Vascular nutritional correlates of late-life depression.

Journal Article Am J Geriatr Psychiatry · September 2006 OBJECTIVE: The authors sought to examine the association of vascular nutritional factors and depression in an elderly cohort of depression (currently and recently depressed) and comparison (never depressed) subjects. METHOD: Nutrient intake over the past y ... Full text Link to item Cite

White matter and subcortical gray matter lesion volume changes and late-life depression outcome: a 4-year magnetic resonance imaging study.

Journal Article Int Psychogeriatr · September 2006 BACKGROUND: Cross-sectional studies have shown that late-onset depression is associated with larger deep white matter lesions (WMLs) and subcortical gray matter lesions (GMLs). In a longitudinal analysis, we examined changes in deep WMLs and subcortical GM ... Full text Link to item Cite

Risk factors for neuropsychiatric symptoms in dementia: the Cache County Study.

Journal Article Int J Geriatr Psychiatry · September 2006 OBJECTIVE: To investigate the probability of individual neuropsychiatric symptoms in dementia patients as a function of eight risk factors. METHODS: In the Cache County Study, we administered the Neuropsychiatric Inventory (NPI) to 328 dementia patients at ... Full text Link to item Cite

Lobar distribution of lesion volumes in late-life depression: the Biomedical Informatics Research Network (BIRN).

Journal Article Neuropsychopharmacology · July 2006 White matter hyperintense lesions on T2-weighted images are associated with late-life depression. Little work has been carried out examining differences in lesion location between elderly individuals with and without depression. In contrast to previous stu ... Full text Link to item Cite

Cognitive function in late life depression: relationships to depression severity, cerebrovascular risk factors and processing speed.

Journal Article Biol Psychiatry · July 1, 2006 BACKGROUND: A number of studies have examined clinical factors linked to worse neuropsychological performance in late life depression (LLD). To understand the influence of LLD on cognition, it is important to determine if deficits in a number of cognitive ... Full text Link to item Cite

A population-based study of the association between coronary artery bypass graft surgery (CABG) and cognitive decline: the Cache County study.

Journal Article Int J Geriatr Psychiatry · June 2006 BACKGROUND: The relationship between coronary artery bypass graft (CABG) surgery and cognitive decline remains uncertain, in particular with regard to whether there is delayed cognitive decline associated with this procedure. METHODS: This was a population ... Full text Link to item Cite

Gender differences in the association between religious involvement and depression: the Cache County (Utah) study.

Journal Article J Gerontol B Psychol Sci Soc Sci · May 2006 We examined the relation between religious involvement, membership in the Church of Jesus Christ of Latter-Day Saints, and major depression in a population-based study of aging and dementia in Cache County, Utah. Participants included 4,468 nondemented ind ... Full text Link to item Cite

Cognitive impairment and depression outcomes in the IMPACT study.

Journal Article Am J Geriatr Psychiatry · May 2006 INTRODUCTION: It is unclear whether cognitive impairment affects acute and long-term treatment response in geriatric depression. In addition, little is known about the long-term outcome of depression among older individuals who experience cognitive decline ... Full text Link to item Cite

Partial remission. A common outcome in older adults treated for major depression.

Journal Article Geriatrics · April 2006 Major depression can affect up to 10% of older adults in clinical samples. Longitudinal studies of older adults with major depression report that a significant proportion of patients do not fully recover. Partial remission or symptoms of major depression t ... Link to item Cite

Three-year incidence of first-onset depressive syndrome in a population sample of older adults: the Cache County study.

Journal Article Am J Geriatr Psychiatry · March 2006 OBJECTIVE: Estimates of incidence of late-life depression vary greatly with few studies excluding demented cases through in-depth evaluation and most studies failing to control for the effect of mortality and interval treatment. In a large population-based ... Full text Link to item Cite

Hippocampal volume is associated with physician-reported acute cognitive deficits after electroconvulsive therapy.

Journal Article J Geriatr Psychiatry Neurol · March 2006 Predicting memory problems in older depressed patients receiving electroconvulsive therapy (ECT) is difficult. In this study, hippocampal volume and acute memory outcomes were examined in 15 patients following an index course of ECT. Smaller hippocampal vo ... Full text Link to item Cite

Perspectives on depression, mild cognitive impairment, and cognitive decline.

Journal Article Arch Gen Psychiatry · February 2006 CONTEXT: The public health implications of depression and cognitive impairment in late life are enormous. Cognitive impairment and late-life depression are associated with increased risk for subsequent dementia; however, investigations of these phenomena a ... Full text Link to item Cite

Depression treatment preferences in older primary care patients.

Journal Article Gerontologist · February 2006 PURPOSE: For depressed older primary care patients, this study aimed to examine (a) characteristics associated with depression treatment preferences; (b) predictors of receiving preferred treatment; and (c) whether receiving preferred treatment predicted s ... Full text Link to item Cite

Ascending digits task as a measure of executive function in geriatric depression.

Journal Article J Neuropsychiatry Clin Neurosci · 2006 The authors hypothesized that older depressed patients would perform more poorly on the Ascending Digits Task (ADT) when matched against a nondepressed elderly comparison group. In a novel measure, the ADT, 129 older depressives scored more poorly than 129 ... Full text Link to item Cite

Comparison of clinical and neuropathologic diagnoses of Alzheimer's disease in 3 epidemiologic samples.

Journal Article Alzheimers Dement · January 2006 BACKGROUND: Studies of dementia in populations avoid many of the selection biases in clinical samples but require special evaluation and diagnostic methods to obtain high participation rates. To address this issue, we developed a unique in-home dementia as ... Full text Link to item Cite

Clinical correlates of anxious depression among elderly patients with depression.

Journal Article J Affect Disord · January 2006 OBJECTIVE: The purpose of this study was to determine the clinical correlates of comorbid anxiety and depression in a sample of older patients with major depression. METHODS: 352 patients aged 59 and older with major depression were enrolled in the Study o ... Full text Link to item Cite

Managing patients with vascular disease and depression

Journal Article Journal of Clinical Psychiatry · January 1, 2006 Full text Cite

Residual symptoms in older patients treated for major depression.

Journal Article Int J Geriatr Psychiatry · December 2005 OBJECTIVE: The purpose of this study was to identify residual symptoms in a sample of older adults treated for major depression and compare individual symptoms present at baseline with those at three months by remission status. METHODS: The sample was comp ... Full text Link to item Cite

Hippocampal volume as a predictor of short-term ECT outcomes in older patients with depression.

Journal Article Am J Geriatr Psychiatry · October 2005 OBJECTIVE: The authors examined the relationship between hippocampal volume and acute electroconvulsive therapy (ECT) outcomes. METHODS: Depression was measured by Montgomery-Asberg Depression Rating Scale (MADRS) scores, and hippocampal volume was assesse ... Full text Link to item Cite

Symptomatic remission in patients with bipolar mania: results from a double-blind, placebo-controlled trial of risperidone monotherapy.

Journal Article J Clin Psychiatry · August 2005 BACKGROUND: The purpose of this analysis was to assess rates of symptomatic remission in patients with bipolar mania receiving risperidone in a double-blind, parallel-group, multicenter, placebo-controlled trial conducted in India. METHOD: Two hundred nine ... Full text Link to item Cite

Predictors of partial remission in older patients treated for major depression: the role of comorbid dysthymia.

Journal Article Am J Geriatr Psychiatry · August 2005 OBJECTIVE: The authors studied demographic, clinical, social, and perceived health and well-being factors as predictors of partial remission in older patients treated for major depressive disorder (MDD). METHODS: The sample included 186 patients who met DS ... Full text Link to item Cite

Hormone therapy does not affect depression severity in older women.

Journal Article Am J Geriatr Psychiatry · July 2005 OBJECTIVE: Although estrogens are thought to have a beneficial effect on menopausal symptoms, the role of estrogen in the etiology and treatment of depression in older women remains unclear. The authors examined the relationship between hormone therapy (HT ... Full text Link to item Cite

Greater MRI lesion volumes in elderly depressed subjects than in control subjects.

Journal Article Psychiatry Res · May 30, 2005 Hyperintense lesions in both white matter and gray matter on T2-weighted magnetic resonance imaging (MRI) are associated with late-life depression. This large study examined differences in gray and white matter lesion volumes on brain MRI between 253 elder ... Full text Link to item Cite

Influence of serotonin transporter promoter region polymorphisms on hippocampal volumes in late-life depression.

Journal Article Arch Gen Psychiatry · May 2005 CONTEXT: Polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR) influence transcription and may play a role in the pathogenesis and course of depression. Recent research demonstrates that specific polymorphisms may be associated ... Full text Link to item Cite

Biological and social predictors of long-term geriatric depression outcome.

Journal Article Int Psychogeriatr · March 2005 OBJECTIVE: In this study, we examined 204 older depressed individuals for up to 64 months to determine factors related to depression outcome. We hypothesized that both presence of vascular brain lesions seen on baseline magnetic resonance imaging (MRI) sca ... Full text Link to item Cite

Social support and locus of control as predictors of adherence to antidepressant medication in an elderly population.

Journal Article Am J Geriatr Psychiatry · February 2005 OBJECTIVE: The authors examined whether social support and locus of control (LOC), either individually or jointly, would be associated with subsequent self-reported medication adherence and treatment barriers in a sample of depressed elderly patients. METH ... Full text Link to item Cite

The Aging, Demographics, and Memory Study: study design and methods.

Journal Article Neuroepidemiology · 2005 OBJECTIVE: We describe the design and methods of the Aging, Demographics, and Memory Study (ADAMS), a new national study that will provide data on the antecedents, prevalence, outcomes, and costs of dementia and "cognitive impairment, not demented" (CIND) ... Full text Link to item Cite

Prevalence and clinical correlates of neuropsychiatric symptoms in dementia.

Journal Article Am J Alzheimers Dis Other Demen · 2005 The purpose of this research was to assess the frequency and severity of neuropsychiatric and behavioral symptoms and to examine the association between preexisting medical conditions and specific neuropsychiatric symptoms in demented individuals. We studi ... Full text Link to item Cite

A population study of Alzheimer's disease: findings from the Cache County Study on Memory, Health, and Aging.

Journal Article Care Manag J · 2005 There are several population-based studies of aging, memory, and dementia being conducted worldwide. Of these, the Cache County Study on Memory, Health and Aging is noteworthy for its large number of "oldest-old" members. This study, which has been followi ... Full text Link to item Cite

Impact of symptoms of generalized anxiety disorder on the course of late-life depression.

Journal Article Am J Geriatr Psychiatry · January 2005 OBJECTIVE: The authors sought to examine the effect of symptoms of generalized anxiety disorder (GAD) on acute course of depression in a group of older depressed patients. METHODS: Authors assessed GAD symptoms in a sample of 204 patients age 60 and older ... Full text Link to item Cite

Age effects of coronary artery bypass graft on cognitive status change among elderly male twins.

Journal Article Neurology · December 28, 2004 BACKGROUND: Research regarding long-term cognitive outcome following coronary artery bypass graft (CABG) is inconsistent, which may be due in part to differential genetic and environmental influences within most study samples. METHODS: The authors examined ... Full text Link to item Cite

Prefrontal neuropsychological predictors of treatment remission in late-life depression.

Journal Article Neuropsychopharmacology · December 2004 Recent studies suggest that neuropsychological measures involving the prefrontal cortex are associated with treatment remission in late-life depression. To further explore this issue, we studied the neuropsychological performance of 110 depressed individua ... Full text Link to item Cite

Methodology and preliminary results from the neurocognitive outcomes of depression in the elderly study.

Journal Article J Geriatr Psychiatry Neurol · December 2004 A methodology is presented for following a cohort of older depressed patients to examine neurocognitive outcomes of depression. A total of 265 depressed individuals and 138 healthy, nondepressed controls age 60 and older who completed at least 1 year of fo ... Full text Link to item Cite

Is there a definition of remission in late-life depression that predicts later relapse?

Journal Article Neuropsychopharmacology · December 2004 Remission of depressive symptoms is the goal of all antidepressant therapy. Rating scales define remission in clinical trials, but it is unclear how well these definitions predict risk of later relapse. We measured the sensitivity and specificity of a rang ... Full text Link to item Cite

Establishing diagnostic criteria for vascular depression.

Journal Article J Neurol Sci · November 15, 2004 We have proposed a subtype of vascular depression with two key elements: (1) presence of major depression and (2) presence of cerebrovascular disease on neuroimaging. Future studies are needed to refine these diagnostic criteria. There must be a consensus ... Full text Link to item Cite

Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter.

Journal Article Am J Psychiatry · July 2004 OBJECTIVE: The purpose of this study was to determine whether microstructural abnormalities in the white matter of the dorsolateral prefrontal cortex are associated with late-life depression. METHOD: Seventeen elderly depressed subjects were compared with ... Full text Link to item Cite

Depression in the elderly: A timely update

Journal Article Primary Psychiatry · May 1, 2004 Cite

Fitness levels of middle aged martial art practitioners.

Journal Article Br J Sports Med · April 2004 OBJECTIVES: To quantify and compare fitness levels of middle aged practitioners of soo bahk do (SBD; a Korean martial art similar to karate) with those of sedentary subjects. METHODS: Eighteen volunteers, 14 men and four women (aged 40-60 years), participa ... Full text Link to item Cite

Clinical characteristics of magnetic resonance imaging-defined subcortical ischemic depression.

Journal Article Biol Psychiatry · February 15, 2004 BACKGROUND: There is a substantial body of research supporting the vascular depression hypothesis of late-life depression. To update this hypothesis so it incorporates recent research, we propose that the term subcortical ischemic vascular depression may b ... Full text Link to item Cite

Statin use and hippocampal volumes in elderly subjects at risk for Alzheimer's disease: a pilot observational study.

Journal Article Am J Alzheimers Dis Other Demen · 2004 Statins are investigational therapies for preventing or treating Alzheimer's disease (AD) and mild cognitive impairment (MCI). Hippocampal atrophy is a characteristic feature of MCI and AD. This study analyzed cross-sectional data from 246 nondemented elde ... Full text Link to item Cite

The persistence of neuropsychiatric symptoms in dementia: the Cache County Study.

Journal Article Int J Geriatr Psychiatry · January 2004 OBJECTIVE: To estimate the 18-month persistence of neuropsychiatric symptoms in dementia in a population-based sample, and to compare the severity of neuropsychiatric symptoms at baseline to the severity at 18-month follow-up. METHODS: A population-based s ... Full text Link to item Cite

The association of psychosocial factors and depression with hypertension among older adults.

Journal Article Int J Geriatr Psychiatry · December 2003 OBJECTIVE: To examine the relationship between depression and hypertension in an elderly population and how psychosocial variables influence this relationship. METHODS: The study included 293 subjects, who met DSM-IV criteria for unipolar depression, and 1 ... Full text Link to item Cite

Diagnostic criteria for Depression of Alzheimer disease (DAD)

Journal Article Research and Practice in Alzheimer's Disease · December 1, 2003 This chapter focuses on the development of diagnostic criteria for Depression of Alzheimer disease. Depression of Alzheimer's disease is similar to major depression, but relies less on verbal reporting, requires fewer symptoms, and includes irritability as ... Cite

Left orbital frontal cortex volume and performance on the benton visual retention test in older depressives and controls.

Journal Article Neuropsychopharmacology · December 2003 Changes within the prefrontal cortex (PFC) have been associated with both mood disorders and with specific impairments in cognitive testing. The left PFC has been implicated in relational processing, that is, binding different pieces of information. We hyp ... Full text Link to item Cite

White matter hyperintensity progression and late-life depression outcomes.

Journal Article Arch Gen Psychiatry · November 2003 CONTEXT: White matter hyperintensities (WMHs) are bright foci seen in the parenchyma of the brain on T2-weighted cranial magnetic resonance imaging (MRI) scans and are associated with geriatric depression. Because they are associated with age, they should ... Full text Link to item Cite

Apolipoprotein E genotype and subcortical vascular lesions in older depressed patients and control subjects.

Journal Article Biol Psychiatry · October 1, 2003 BACKGROUND: Several studies have linked geriatric depression with cerebrovascular disease. The apolipoprotein E gene (APOE) epsilon 4 allele has been associated with a variety of late-life neuropsychiatric disorders, including Alzheimer's disease, vascular ... Full text Link to item Cite

The impact of religious practice and religious coping on geriatric depression.

Journal Article Int J Geriatr Psychiatry · October 2003 OBJECTIVE: Both religiousness and social support have been shown to influence depression outcome, yet some researchers have theorized that religiousness largely reflects social support. We set out to determine the relationship of religiousness with depress ... Full text Link to item Cite

Subcortical lesion severity and orbitofrontal cortex volume in geriatric depression.

Journal Article Biol Psychiatry · September 1, 2003 Previous studies have shown a reduction of orbital frontal cortex volume and an increase in magnetic resonance imaging signal hyperintensities in geriatric depression. We aimed to assess the relationship between subcortical gray- and deep white-matter lesi ... Full text Link to item Cite

Serial MR imaging of volumes of hyperintense white matter lesions in elderly patients: correlation with vascular risk factors.

Journal Article AJR Am J Roentgenol · August 2003 OBJECTIVE: The purpose of the study was to examine change in volume of hyperintense white matter lesions in a cohort of community-dwelling elderly subjects without neuropsychiatric disease. SUBJECTS AND METHODS. One hundred seventeen volunteers underwent b ... Full text Link to item Cite

Localization of age-associated white matter hyperintensities in late-life depression.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · May 2003 OBJECTIVE: Deep white matter hyperintense lesions are associated with advanced age and late-life depression. The authors examined where age-related cerebral lesions occurred in elderly depressed and healthy control subjects. METHODS: Eighty-seven depressed ... Full text Link to item Cite

Apolipoprotein E genotype and major depression in a community of older adults. The Cache County Study.

Journal Article Psychol Med · April 2003 BACKGROUND: The role of allelic variation in APOE, the genetic locus for apolipoprotein E, in geriatric depression is poorly understood. There are conflicting reports as to an association between the epsilon4 allele and depression in late life. METHOD: Usi ... Full text Link to item Cite

Associations among the NEO Personality Inventory, Revised and the serotonin transporter gene-linked polymorphic region in elders: effects of depression and gender.

Journal Article Psychiatr Genet · March 2003 OBJECTIVE: The short variant of the serotonin transporter gene-linked functional polymorphic region (5-HTTLPR) has been associated with personality traits related to anxiety, hostility, and depression. We attempted to replicate findings suggesting a positi ... Full text Link to item Cite

Smaller orbital frontal cortex volumes associated with functional disability in depressed elders.

Journal Article Biol Psychiatry · January 15, 2003 BACKGROUND: Depression is associated with significant functional impairment. Recent evidence has linked the orbital frontal cortex (OFC) with depression. We examined the relationship between OFC volumes in older subjects and impairment in the basic (BADL) ... Full text Link to item Cite

MRI lesion severity and mortality in geriatric depression.

Journal Article Am J Geriatr Psychiatry · 2003 OBJECTIVE: The authors correlated magnetic resonance imaging (MRI) lesion severity and mortality among depressed elderly patients. METHOD: They examined the association of mortality and deep white-matter hyperintensity (DWMH), periventricular hyperintensit ... Full text Link to item Cite

A three-factor analytic model of the MADRS in geriatric depression.

Journal Article Int J Geriatr Psychiatry · January 2003 OBJECTIVE: Major depression is a heterogeneous disorder, perhaps comprising several clinical subtypes or subgroups of symptoms. This study examined whether items on the Montgomery-Asberg Depression Rating Scale (MADRS) form distinct symptom subgroups among ... Full text Link to item Cite

Partial response as a predictor of outcome in geriatric depression.

Journal Article Am J Geriatr Psychiatry · 2003 OBJECTIVE: Although geriatric depression generally responds to treatment, patients are often left with residual symptoms after acute treatment. Data are lacking on the eventual outcomes of individuals who are partial responders or poor responders to initia ... Link to item Cite

Implementing a disease management intervention for depression in primary care: a random work sampling study.

Journal Article Gen Hosp Psychiatry · 2003 We describe the daily work activities of 13 Depression Clinical Specialists (DCSs) at 7 national sites who served as care managers in an effective multisite randomized trial of a disease management model for depression in primary care. DCSs carried portabl ... Full text Link to item Cite

The incidence of mental and behavioral disturbances in dementia: the cache county study.

Journal Article J Neuropsychiatry Clin Neurosci · 2003 A population-based prevalence sample of 355 residents of Cache County, Utah, who were diagnosed with dementia, was rated on the Neuropsychiatric Inventory (NPI). Of the 355 residents, 119 had no neuropsychiatric symptoms at baseline and were, consequently, ... Full text Link to item Cite

Cholesterol-lowering medication and relapse of depression.

Journal Article Psychopharmacol Bull · 2003 This study sought to examine the effects of taking cholesterol-lowering medication on outcomes of depression among older depressed adults. 243 elderly depressed patients were treated using an antidepressant algorithm by a geriatric psychiatrist who adminis ... Link to item Cite

Provisional diagnostic criteria for depression of Alzheimer's disease: description and review.

Journal Article Expert Rev Neurother · January 2003 This review centers on the development of diagnostic criteria for depression of Alzheimer's disease. It describes: risk-factors and neurobiological correlates, epidemiology, clinical characteristics and course, assessment, treatment, economics, a descripti ... Full text Link to item Cite

Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study.

Journal Article JAMA · November 6, 2002 CONTEXT: Previous studies have shown a sex-specific increased risk of Alzheimer disease (AD) in women older than 80 years. Basic neuroscience findings suggest that hormone replacement therapy (HRT) could reduce a woman's risk of AD. Epidemiologic findings ... Full text Link to item Cite

Investigation of Notch3 as a candidate gene for bipolar disorder using brain hyperintensities as an endophenotype.

Journal Article Am J Med Genet · August 8, 2002 The purpose of the study was to consider MRI hyperintensities as a potential endophenotype for bipolar disorder (BPD) and to investigate Notch3 (CADASIL) as a candidate gene for BPD. MRI scans were performed on 21 members of a family with a high incidence ... Full text Link to item Cite

Anatomic location and laterality of MRI signal hyperintensities in late-life depression.

Journal Article J Psychosom Res · August 2002 OBJECTIVES: Evidence is mounting linking cerebrovascular disease with the development of major depression in the elderly. Lesions in both white and gray matter have been associated with geriatric depression. In addition, the literature on poststroke depres ... Full text Link to item Cite

Hippocampal volume and antidepressant response in geriatric depression.

Journal Article Int J Geriatr Psychiatry · June 2002 BACKGROUND: Biological markers of treatment response may include structural brain changes seen on neuroimaging. While most imaging studies have focused on cerebrovascular disease, evidence is growing that the hippocampus may play a role in depression, part ... Full text Link to item Cite

Behavioral medicine and aging.

Journal Article J Consult Clin Psychol · June 2002 A brief history of behavioral medicine and aging is followed by a series of perspectives that help to understand how age is used as a variable in this research, the relative importance of age to declines in cognitive functioning, and the impact of behavior ... Full text Link to item Cite

Cerebrovascular disease and evolution of depressive symptoms in the cardiovascular health study.

Journal Article Stroke · June 2002 BACKGROUND AND PURPOSE: Previous studies have reported an association between cerebrovascular disease and depressive symptoms. The Cardiovascular Health Study (CHS) provides an opportunity to examine the relationship between vascular brain pathology seen o ... Full text Link to item Cite

APOE genotype and hippocampal volume change in geriatric depression.

Journal Article Biol Psychiatry · March 1, 2002 BACKGROUND: Apolipoprotein E has been associated with hippocampal volume loss in Alzheimer's disease and in elderly controls. In this study, we examined the role of apolipoprotein E and hippocampal volume change in 45 older nondemented depressed subjects. ... Full text Link to item Cite

Psychosocial and clinical predictors of unipolar depression outcome in older adults.

Journal Article Int J Geriatr Psychiatry · March 2002 BACKGROUND: This study examined psychosocial and clinical predictors of depression non-remittance among a sample of initially clinically depressed elders. METHODS: Incident and prevalent unipolar depression cases (n = 166) were enrolled into the MHCRC for ... Full text Link to item Cite

An adaptation of the modified mini-mental state examination: analysis of demographic influences and normative data: the cache county study.

Journal Article Neuropsychiatry Neuropsychol Behav Neurol · March 2002 OBJECTIVES: To present a new version of the Modified Mini-Mental State Examination (3MS-R), provide normative information extending to individuals in the 10th decade, and examine the effects of demographic variables on test performance. BACKGROUND: The Mod ... Link to item Cite

Hippocampal volume and incident dementia in geriatric depression.

Journal Article Am J Geriatr Psychiatry · 2002 The authors investigated the role of baseline hippocampal volume on later clinical emergence of dementia in a group of older, non-demented depressed individuals. Subjects were 115 depressed, non-demented participants in a mental health clinical research ce ... Link to item Cite

Greater depression severity associated with less improvement in depression-associated cognitive deficits in older subjects.

Journal Article Am J Geriatr Psychiatry · 2002 OBJECTIVES: Elderly depressed patients often exhibit cognitive deficits, which may improve with drug therapy. The authors investigated the relationship of baseline depression severity and cognitive improvement with antidepressant treatment in depressed pat ... Link to item Cite

Allelic differences in the serotonin transporter-linked polymorphic region in geriatric depression.

Journal Article Am J Geriatr Psychiatry · 2002 Previous studies have examined the role of genetic variations in the serotonin transporter-linked polymorphic region (5HTTLPR) in affective disorders. The authors studied 182 older depressed subjects and 107 elderly control subjects and obtained DNA for ge ... Link to item Cite

Subcortical white matter lesions and functional impairment in geriatric depression.

Journal Article Depress Anxiety · 2002 Geriatric depression is associated with significant functional impairment. There is also growing evidence linking vascular brain changes to depression in late life. We sought to examine the relationship between cerebrovascular disease and impairment in bas ... Full text Link to item Cite

Time-to-remission from geriatric depression: psychosocial and clinical factors.

Journal Article Am J Geriatr Psychiatry · 2002 OBJECTIVE: The authors examined psychosocial and clinical predictors of time-to-remission in a sample of initially clinically depressed elderly patients. METHODS: Using a standardized algorithm, a prospective cohort study enrolled 239 patients undergoing t ... Link to item Cite

Head injury in early adulthood and the lifetime risk of depression.

Journal Article Arch Gen Psychiatry · January 2002 BACKGROUND: Depressive symptoms are common and can be debilitating in the months after head injury. Head injury can also have long-term cognitive effects, but little is known about the long-term risk of depression associated with head injury. We investigat ... Full text Link to item Cite

Treating depression in primary care: An innovative role for mental health nurses

Journal Article Journal of the American Psychiatric Nurses Association · January 1, 2002 Late-life depression is common in primary care. However, because of barriers such as stigma and the assumption that depression in older adults is a normal part of aging, it is often underrecognized and undertreated. Further, most primaty care providers do ... Full text Cite

Sociodemographic and clinical predictors of mortality in geriatric depression.

Journal Article Am J Geriatr Psychiatry · 2002 OBJECTIVE: It is well documented that depression and early mortality are related, and current research suggests that depression may influence vascular causes of death. The authors report on prospectively observed mortality in elderly depressed patients, co ... Link to item Cite

The Duke Somatic Treatment Algorithm for Geriatric Depression (STAGED) approach.

Journal Article Psychopharmacol Bull · 2002 Although there have been previously published algorithms for the treatment of depression, few have been rigorously studied in terms of outcome. We present the Duke Somatic Treatment Algorithm for Geriatric Depression (STAGED) approach, developed by clinici ... Link to item Cite

Provisional diagnostic criteria for depression of Alzheimer disease.

Journal Article Am J Geriatr Psychiatry · 2002 The authors, a group of investigators with extensive research and clinical experience related to both late-life depression and Alzheimer disease (AD), propose provisional affective and behavioral inclusion and exclusion diagnostic criteria for Depression o ... Link to item Cite

Hormone replacement therapy and reduced cognitive decline in older women: the Cache County Study.

Journal Article Neurology · December 26, 2001 OBJECTIVE: To examine the association between postmenopausal hormone replacement therapy (HRT) and the trajectory of global cognitive change with age. METHODS: The Modified Mini-Mental State Examination (MMSE) was administered to a population sample of 2,0 ... Full text Link to item Cite

Does social support buffer functional decline in elderly patients with unipolar depression?

Journal Article Am J Psychiatry · November 2001 OBJECTIVE: This study tested whether social support protects against functional decline, either generally or selectively, in the most severely depressed elderly patients undergoing treatment for major depressive disorder. METHOD: In a prospective cohort st ... Full text Link to item Cite

Neuropsychiatric disturbance in Alzheimer's disease clusters into three groups: the Cache County study.

Journal Article Int J Geriatr Psychiatry · November 2001 OBJECTIVE: We investigated the frequency and inter-relationship of neuropsychiatric disturbances in a population sample of persons suffering from Alzheimer's disease (AD). METHOD: Screening 5,092 elderly residents (90% of the population aged 65 and older) ... Full text Link to item Cite

Bupropion SR in the naturalistic treatment of elderly patients with major depression.

Journal Article Int J Geriatr Psychiatry · September 2001 INTRODUCTION: Bupropion immediate release (IR) and bupropion sustained release (SR) are frequently used to treat geriatric depression, as they have few cardiovascular, gastrointestinal and sexual adverse effects. We sought to examine the efficacy and dosin ... Full text Link to item Cite

Performance feedback deficit in geriatric depression.

Journal Article Biol Psychiatry · September 1, 2001 BACKGROUND: The orbital frontal cortex is involved with processing of performance feedback. This study tests the hypothesis that older depressed subjects, compared with elderly control subjects, commit more subsequent errors after receiving feedback from a ... Full text Link to item Cite

Diagnosis, epidemiology, and clinical course of geriatric depression

Journal Article Economics of Neuroscience · August 25, 2001 The elderly population is steadily growing. It is projected that the number of persons age 65 and older will more than the double between now and 2050. As this population grows, an increasing percentage of the elderly will experience psychiatric disorders ... Cite

MRI correlates of suicide attempt history in unipolar depression.

Journal Article Biol Psychiatry · August 15, 2001 BACKGROUND: Suicide represents a major health problem in the United States, and prediction of suicide attempts is difficult. No structural neuroimaging studies have been done to specifically examine findings in patients who have attempted suicide. The obje ... Full text Link to item Cite

Evidence of white matter tract disruption in MRI hyperintensities.

Journal Article Biol Psychiatry · August 1, 2001 BACKGROUND: Diffusion tensor imaging (DTI) of brain tissue measures the apparent diffusion coefficient (ADC), or isotropic diffusion, and anisotropy, or diffusion as influenced by tissue structure. We hypothesized that hyperintensities, when compared with ... Full text Link to item Cite

Severity of subcortical gray matter hyperintensity predicts ECT response in geriatric depression.

Journal Article J ECT · March 2001 OBJECTIVE: To determine the effect of subcortical white and gray matter lesions on ECT outcome. METHOD: 41 geriatric psychiatric inpatients underwent an MRI scan during their ECT work-up. Periventricular, deep white matter, and subcortical gray matter hype ... Full text Link to item Cite

Depressive symptoms, menopausal status, and climacteric symptoms in women at midlife.

Journal Article Psychosom Med · 2001 OBJECTIVE: Previous studies have found increased rates of depression in women aged 45 to 54 years, but the factors that influence these rates are not understood. It was assessed whether higher rates of depressive symptoms were associated with menopausal st ... Full text Link to item Cite

Relation of subjective and received social support to clinical and self-report assessments of depressive symptoms in an elderly population.

Journal Article J Affect Disord · December 2000 BACKGROUND: The authors sought to evaluate the associations between depressive symptoms and social support in a sample drawn from a relatively understudied population - depressed elderly patients. The present study also used a multi-measure approach to ass ... Full text Link to item Cite

Reduction of orbital frontal cortex volume in geriatric depression.

Journal Article Biol Psychiatry · November 15, 2000 BACKGROUND: Postmortem studies have documented abnormalities in the medial orbital frontal cortex in depressed patients. In this study we evaluated whether atrophy of this region can be identified in older depressed patients using magnetic resonance imagin ... Full text Link to item Cite

Grey-matter lesions and dementia.

Journal Article Lancet · November 11, 2000 Full text Link to item Cite

Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias.

Journal Article Neurology · October 24, 2000 BACKGROUND: The association between antecedent head injury and AD is inconsistent. OBJECTIVE: To examine the association between early adult head injury, as documented by military hospital records, and dementia in late life; and to evaluate the interaction ... Full text Link to item Cite

Hippocampal volume in geriatric depression.

Journal Article Biol Psychiatry · August 15, 2000 BACKGROUND: There is a growing literature on the importance of hippocampal volume in geriatric depression. METHODS: We examined hippocampal volume in a group of elderly depressed patients and a group of elderly control subjects (N = 66 geriatric depressed ... Full text Link to item Cite

Prevalence of depression and its treatment in an elderly population: the Cache County study.

Journal Article Arch Gen Psychiatry · June 2000 BACKGROUND: Previous estimates of the prevalence of geriatric depression have varied. There are few large population-based studies; most of these focused on individuals younger than 80 years. No US studies have been published since the advent of the newer ... Full text Link to item Cite

Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging.

Journal Article Am J Psychiatry · May 2000 OBJECTIVE: The authors report findings from a study of 5,092 community residents who constituted 90% of the elderly resident population of Cache County, Utah. METHOD: The 5,092 participants, who were 65 years old or older, were screened for dementia. Based ... Full text Link to item Cite

APOE and AD concordance in twin pairs as predictors of AD in first-degree relatives.

Journal Article Neurology · February 8, 2000 OBJECTIVE: To examine the independent effects of the APOE genotype (APOE) and concordance for AD in twin pairs on the occurrence of AD in first-degree relatives. BACKGROUND: Studies of twins have been undertaken to investigate the influence of genes in a v ... Full text Link to item Cite

The relationship of social support, social networks and negative events with depression in patients with coronary artery disease

Journal Article Aging and Mental Health · January 1, 2000 This study examined the relationship of social relationships and negative life events with major depression among 335 inpatients with coronary artery disease (CAD) who were free of neurological illnesses. Depression was assessed using the Duke Depression E ... Full text Cite

Geriatric depression: Further evidence for the 'vascular depression' hypothesis

Journal Article Current Opinion in Psychiatry · November 17, 1999 Depression in the elderly is a heterogeneous group of syndromes with many biologic and psychosocial antecedents. Recent studies support the notion that vascular processes may play a role in a subset of geriatric depressions. More recently, studies have att ... Full text Cite

Initial evaluation of suspected dementia. Asking the right questions.

Journal Article Postgrad Med · October 15, 1999 The initial clinical approach to suspected dementia involves asking the right questions of the patient and a knowledgeable family member or caregiver. These questions should focus on the nature of the cognitive problem (e.g., the onset, duration, and sever ... Full text Link to item Cite

Enhanced cognitive performance with estrogen use in nondemented community-dwelling older women.

Journal Article J Am Geriatr Soc · October 1999 OBJECTIVE: To examine the association between history of postmenopausal estrogen use and cognitive function in a large sample of nondemented community-dwelling older women. SETTING: A community of older residents in Cache County, Utah. PARTICIPANTS: A tota ... Full text Link to item Cite

Cerebrovascular disease and depression symptoms in the cardiovascular health study.

Journal Article Stroke · October 1999 BACKGROUND AND PURPOSE: Evidence is mounting linking cerebrovascular disease with depressive symptoms in the elderly. Lesions in both white and gray matter have been associated with depressive symptoms and major depression. We sought to investigate the rel ... Full text Link to item Cite

APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: the Cache County Study.

Journal Article Neurology · July 22, 1999 OBJECTIVE: To examine the prevalence of Alzheimer's disease (AD) and other dementias in relation to age, education, sex, and genotype at APOE. Recent studies suggest age heterogeneity in the risk of AD associated with the APOE genotype and a possible inter ... Full text Link to item Cite

The effect of major depression on functional status in patients with coronary artery disease.

Journal Article J Am Geriatr Soc · March 1999 OBJECTIVE: To examine the effect of major depression on reported functional status in a group of patients with coronary artery disease (CAD). SETTING: An inpatient cardiology service. PARTICIPANTS: Three hundred thirty-five inpatients with coronary artery ... Full text Link to item Cite

Disability in geriatric depression.

Journal Article Am J Geriatr Psychiatry · 1999 The authors examined impairment in self-maintenance skills and in instrumental activities of daily living (IADL) among 211 older patients with unipolar major depression. In regression models, self-maintenance impairment was associated with older age, less ... Link to item Cite

Familial leukoencephalopathy in bipolar disorder.

Journal Article Am J Psychiatry · November 1998 OBJECTIVE: Imaging studies of patients with bipolar disorder demonstrate changes in deep white matter and subcortical gray nuclei that are seen as focal hyperintensities on T2-weighted magnetic resonance imaging (MRI). The objective of this study was to ex ... Full text Link to item Cite

Combination therapy for early Alzheimer's disease: what are we waiting for?

Journal Article J Am Geriatr Soc · October 1998 The practical pharmacological approaches currently available to palliate the cognitive and functional losses in early Alzheimer's disease (AD) include cholinesterase inhibitors (ChEI), antioxidants (e.g., vitamin E), anti-inflammatory agents, estrogen, sel ... Full text Link to item Cite

Magnetic resonance imaging signal hypointensity and iron content of putamen nuclei in elderly depressed patients.

Journal Article Psychiatry Res · August 26, 1998 We previously introduced a semiquantitative scale for assessment of iron content of putamen nuclei as determined by magnetic resonance imaging (MRI)--the Signal Hypointensity in the Putamen (SHIP) scale. Such hypointensity may be related to putamen nuclei ... Full text Link to item Cite

Structural neuroimaging and mood disorders: recent findings, implications for classification, and future directions.

Journal Article Biol Psychiatry · May 15, 1998 Neuroimaging is playing an increasing role in research of affective disorders, with investigators examining both volumetric changes of specific brain structures and vascular changes within white and gray matter. Recent studies have attempted to make clinic ... Full text Link to item Cite

The use of flumazenil in the anxious and benzodiazepine-dependent ECT patient.

Journal Article J ECT · March 1998 Many patients who receive electroconvulsive therapy (ECT) are benzodiazepine dependent or are anxious and require benzodiazepine drugs. Because these agents may diminish the therapeutic effectiveness of ECT, we explored the dosing, safety, and efficacy of ... Link to item Cite

Psychotherapeutic agents in older adults. Metabolism, bioavailability, and drug interactions.

Journal Article Clin Geriatr Med · February 1998 This article presents clinically relevant drug interactions which may confront the geriatric psychiatrist. Changes in drug metabolism due to aging, higher medical comorbidity, and frequent polypharmacy all place the older patient at a greater risk of devel ... Link to item Cite

Early recognition of Alzheimer's disease: what is consensual? What is controversial? What is practical?

Journal Article J Clin Psychiatry · 1998 Alzheimer's disease is often unrecognized or misdiagnosed in its early stages. Despite the lack of curative treatments, there are compelling reasons why early recognition of Alzheimer's disease may offer substantial benefits. Early evaluation and diagnosis ... Link to item Cite

A review of racial differences in geriatric depression: implications for care and clinical research.

Journal Article J Natl Med Assoc · November 1997 How racial differences influence depressed elders' seeking and obtaining treatment for depression is poorly understood. Studies in other medical illnesses show older African Americans use fewer health-care services for heart disease, stroke, and renal dial ... Link to item Cite

A twin study of late-onset depression and apolipoprotein E epsilon 4 as risk factors for Alzheimer's disease.

Journal Article Biol Psychiatry · April 15, 1997 A prior history of depression and the epsilon 4 allele of apolipoprotein E (APOE) have each been associated with development of Alzheimer's disease (AD). In a sample of 142 elderly twins from a large study of dementia, we examined the relation of major dep ... Full text Link to item Cite

Are SSRIs better than TCAs? Comparison of SSRIs and TCAs: a meta-analysis.

Journal Article Depress Anxiety · 1997 In this analysis we examined studies of tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) to compare efficacy and drop-out rates. Frequency of reported side effects was also studied. Using Medline, we located 36 clinical ... Full text Link to item Cite

Magnetic resonance imaging changes in putamen nuclei iron content and distribution in normal subjects.

Journal Article Psychiatry Res · November 25, 1996 To study patterns of iron deposition in the putamen in aging, we reviewed brain magnetic resonance imaging (MRI) scans of 56 normal subjects. We developed the Signal Hypointensity in the Putamen (SHIP) Scale, a semiquantitative measure, to evaluate putamen ... Full text Link to item Cite

Sociodemographic and clinical correlates of number of previous depressive episodes in the depressed elderly.

Journal Article J Affect Disord · July 8, 1996 Age of onset has been used as a correlate of depressive symptomatology in the elderly. Examining frequency of episodes may improve our ability to make such correlations. The authors studied variations in an index presentation of depression in late life bas ... Full text Link to item Cite

Diagnosis of Alzheimer's disease in epidemiologic studies by staged review of clinical data

Journal Article Neuropsychiatry, Neuropsychology and Behavioral Neurology · April 1, 1996 We explored the inter-rater agreement and validity of diagnoses of Alzheimer's disease (AD) and other dementias made in an epidemiological study. A previously described protocol for cognitive screening and clinical assessment was applied to a large registr ... Cite

Decision model for the acute treatment of mania.

Journal Article Depress Anxiety · 1996 Decision making in psychiatric diagnosis and treatment has not been evaluated systematically. The authors present a model for treatment of an acute manic episode using a decision analysis software program. Six treatment options were put into the model: lit ... Full text Link to item Cite

Cost effectiveness of maintenance ECT.

Journal Article Convuls Ther · December 1995 Link to item Cite

Alzheimer's disease in the National Academy of Sciences-National Research Council Registry of Aging Twin Veterans. III. Detection of cases, longitudinal results, and observations on twin concordance.

Journal Article Arch Neurol · August 1995 OBJECTIVES: To detect cases of Alzheimer's disease (AD) in a large population of twins living throughout the United States and to examine concordance for AD in twins as a function of age and genotype for apolipoprotein E (APOE). SETTING: Nationwide survey. ... Full text Link to item Cite

The neurostructural/neurofunctional basis of depression/mania

Journal Article Current Opinion in Psychiatry · January 1, 1993 Full text Cite