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Daniel German Blazer

Professor Emeritus of Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences

Selected Publications


They Call the Sunset Fire.

Journal Article Am J Geriatr Psychiatry · May 2024 Full text Link to item Cite

Resilience and the COVID Pandemic.

Journal Article Am J Geriatr Psychiatry · December 2023 Full text Link to item Cite

Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation.

Journal Article Lancet Diabetes Endocrinol · October 2023 BACKGROUND: The prevalence of type 2 diabetes is increasing rapidly, particularly among younger age groups. Estimates suggest that people with diabetes die, on average, 6 years earlier than people without diabetes. We aimed to provide reliable estimates of ... Full text Link to item Cite

My Comments on Hugh.

Journal Article Am J Geriatr Psychiatry · March 21, 2023 Full text Link to item Cite

From Mouth to Brain: Tooth Loss and Cognitive Impairment.

Journal Article Am J Geriatr Psychiatry · December 2022 Full text Link to item Cite

Mental health care for older adults: recent advances and new directions in clinical practice and research.

Journal Article World Psychiatry · October 2022 The world's population is aging, bringing about an ever-greater burden of mental disorders in older adults. Given multimorbidities, the mental health care of these people and their family caregivers is labor-intensive. At the same time, ageism is a big pro ... Full text Link to item Cite

Review of Religious Variables in Advance Care Planning for End-of-Life Care: Consideration of Faith as a New Construct.

Journal Article Am J Geriatr Psychiatry · July 2022 Religion and spirituality have long been considered important social determinants of human health, and there exists an extensive body of research to support such. End-of-life (EOL) may raise complex questions for individuals about religious and spiritual ( ... Full text Link to item Cite

Domains of delirium severity in Alzheimer's disease and related dementias.

Journal Article J Am Geriatr Soc · May 2022 BACKGROUND: The ability to rate delirium severity is key to providing optimal care for persons with Alzheimer's Disease and Related Dementias (ADRD). Such ratings would allow clinicians to assess response to treatment, recovery time and prognosis, nursing ... Full text Link to item Cite

The Great Health Paradox: A Call for Increasing Investment in Public Health.

Journal Article Acad Med · April 1, 2022 The great health paradox is that the least expensive and most effective public health measures available for addressing the COVID-19 pandemic-and other society-wide health challenges-have long been ignored and rejected in the United States in favor of more ... Full text Link to item Cite

Age differences in trajectories of depressive, anxiety, and burnout symptoms in a population with a high likelihood of persistent occupational distress.

Journal Article Int Psychogeriatr · January 2022 OBJECTIVES: Work in occupations with higher levels of occupational stress can bring mental health costs. Many older adults worldwide are continuing to work past traditional retirement age, raising the question whether older adults experience depression, an ... Full text Link to item Cite

Sexual Harassment, Sexual Assault, and Physical Activity Among U.S. Military Service Members in the Millennium Cohort Study.

Journal Article J Interpers Violence · August 2021 Sexual harassment (SH) and sexual assault (SA) continue to be a focus of prevention efforts in the U.S. military because of the prevalence and potential to affect the health and readiness of service members. Limited research exists on the association of SH ... Full text Link to item Cite

Association Between Depressive Symptoms and Incident Cardiovascular Diseases.

Journal Article JAMA · December 15, 2020 IMPORTANCE: It is uncertain whether depressive symptoms are independently associated with subsequent risk of cardiovascular diseases (CVDs). OBJECTIVE: To characterize the association between depressive symptoms and CVD incidence across the spectrum of low ... Full text Link to item Cite

Hearing loss and psychiatric disorders

Journal Article Hearing Journal · November 1, 2020 Full text Cite

Hands On.

Journal Article Am J Geriatr Psychiatry · October 2020 Full text Link to item Cite

Feeding the Beast.

Journal Article J Am Geriatr Soc · October 2020 Full text Link to item Cite

COVID-19: Financial Stress Test for Academic Medical Centers.

Journal Article Acad Med · August 2020 The coronavirus (COVID-19) pandemic is having profound effects on the lives and well-being of the world's population. All levels of the nation's public health and health care delivery systems are rapidly adjusting to secure the health infrastructure to man ... Full text Link to item Cite

Geriatric Psychiatry.

Journal Article Clin Geriatr Med · May 2020 Full text Link to item Cite

They Call the Sunset Fire.

Journal Article Am J Geriatr Psychiatry · May 2024 Full text Link to item Cite

Resilience and the COVID Pandemic.

Journal Article Am J Geriatr Psychiatry · December 2023 Full text Link to item Cite

Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation.

Journal Article Lancet Diabetes Endocrinol · October 2023 BACKGROUND: The prevalence of type 2 diabetes is increasing rapidly, particularly among younger age groups. Estimates suggest that people with diabetes die, on average, 6 years earlier than people without diabetes. We aimed to provide reliable estimates of ... Full text Link to item Cite

My Comments on Hugh.

Journal Article Am J Geriatr Psychiatry · March 21, 2023 Full text Link to item Cite

From Mouth to Brain: Tooth Loss and Cognitive Impairment.

Journal Article Am J Geriatr Psychiatry · December 2022 Full text Link to item Cite

Mental health care for older adults: recent advances and new directions in clinical practice and research.

Journal Article World Psychiatry · October 2022 The world's population is aging, bringing about an ever-greater burden of mental disorders in older adults. Given multimorbidities, the mental health care of these people and their family caregivers is labor-intensive. At the same time, ageism is a big pro ... Full text Link to item Cite

Review of Religious Variables in Advance Care Planning for End-of-Life Care: Consideration of Faith as a New Construct.

Journal Article Am J Geriatr Psychiatry · July 2022 Religion and spirituality have long been considered important social determinants of human health, and there exists an extensive body of research to support such. End-of-life (EOL) may raise complex questions for individuals about religious and spiritual ( ... Full text Link to item Cite

Domains of delirium severity in Alzheimer's disease and related dementias.

Journal Article J Am Geriatr Soc · May 2022 BACKGROUND: The ability to rate delirium severity is key to providing optimal care for persons with Alzheimer's Disease and Related Dementias (ADRD). Such ratings would allow clinicians to assess response to treatment, recovery time and prognosis, nursing ... Full text Link to item Cite

The Great Health Paradox: A Call for Increasing Investment in Public Health.

Journal Article Acad Med · April 1, 2022 The great health paradox is that the least expensive and most effective public health measures available for addressing the COVID-19 pandemic-and other society-wide health challenges-have long been ignored and rejected in the United States in favor of more ... Full text Link to item Cite

Age differences in trajectories of depressive, anxiety, and burnout symptoms in a population with a high likelihood of persistent occupational distress.

Journal Article Int Psychogeriatr · January 2022 OBJECTIVES: Work in occupations with higher levels of occupational stress can bring mental health costs. Many older adults worldwide are continuing to work past traditional retirement age, raising the question whether older adults experience depression, an ... Full text Link to item Cite

Sexual Harassment, Sexual Assault, and Physical Activity Among U.S. Military Service Members in the Millennium Cohort Study.

Journal Article J Interpers Violence · August 2021 Sexual harassment (SH) and sexual assault (SA) continue to be a focus of prevention efforts in the U.S. military because of the prevalence and potential to affect the health and readiness of service members. Limited research exists on the association of SH ... Full text Link to item Cite

Association Between Depressive Symptoms and Incident Cardiovascular Diseases.

Journal Article JAMA · December 15, 2020 IMPORTANCE: It is uncertain whether depressive symptoms are independently associated with subsequent risk of cardiovascular diseases (CVDs). OBJECTIVE: To characterize the association between depressive symptoms and CVD incidence across the spectrum of low ... Full text Link to item Cite

Hearing loss and psychiatric disorders

Journal Article Hearing Journal · November 1, 2020 Full text Cite

Hands On.

Journal Article Am J Geriatr Psychiatry · October 2020 Full text Link to item Cite

Feeding the Beast.

Journal Article J Am Geriatr Soc · October 2020 Full text Link to item Cite

COVID-19: Financial Stress Test for Academic Medical Centers.

Journal Article Acad Med · August 2020 The coronavirus (COVID-19) pandemic is having profound effects on the lives and well-being of the world's population. All levels of the nation's public health and health care delivery systems are rapidly adjusting to secure the health infrastructure to man ... Full text Link to item Cite

Geriatric Psychiatry.

Journal Article Clin Geriatr Med · May 2020 Full text Link to item Cite

Hearing Loss: The Silent Risk for Psychiatric Disorders in Late Life.

Journal Article Clin Geriatr Med · May 2020 Hearing loss is among the most frequent problems experienced by older adults, yet psychiatrists and other clinicians often ignore the problem as an aggravation rather than recognizing that the problem might benefit from appropriate hearing health care. Man ... Full text Link to item Cite

A Bridge to I Know Not Where.

Journal Article Am J Geriatr Psychiatry · February 2020 Full text Link to item Cite

World Health Organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions.

Journal Article Lancet Glob Health · October 2019 BACKGROUND: To help adapt cardiovascular disease risk prediction approaches to low-income and middle-income countries, WHO has convened an effort to develop, evaluate, and illustrate revised risk models. Here, we report the derivation, validation, and illu ... Full text Link to item Cite

Hearing loss and psychiatric disorders: a review.

Journal Article Psychol Med · April 2019 Hearing loss is one of the most common yet unrecognized impairments experienced by adults, especially as they age. Mental health investigators and practitioners require better understanding of hearing loss, its association with psychiatric disorders, and t ... Full text Link to item Cite

The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.

Journal Article J Am Geriatr Soc · April 2019 BACKGROUND/OBJECTIVES: Every year, up to 40% of the more than 16 million older Americans who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD) or delirium. Each of these distinct syndromes is associated with decreased quality of ... Full text Open Access Link to item Cite

Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies.

Journal Article Eur Heart J · February 14, 2019 AIMS: There is debate about the optimum algorithm for cardiovascular disease (CVD) risk estimation. We conducted head-to-head comparisons of four algorithms recommended by primary prevention guidelines, before and after 'recalibration', a method that adapt ... Full text Open Access Link to item Cite

The New Science of Practical Wisdom.

Journal Article Perspect Biol Med · 2019 Wisdom has been discussed for centuries in religious and philosophical texts. It is often viewed as a fuzzy psychological construct analogous to consciousness, stress, and resilience. This essay provides an understanding of wisdom as a scientific construct ... Full text Link to item Cite

Older Adults

Chapter · 2019 Cite

Persistent Depressive Symptoms in a Population With High Levels of Occupational Stress: Trajectories Offer Insights Into Both Chronicity and Resilience.

Journal Article J Psychiatr Pract · November 2018 Religious participation and spirituality are linked to good mental health. However, clergy may experience more depression than is observed in the general population, which may be due in part to high job strain. The objectives of this study were to identify ... Full text Link to item Cite

Spirituality in geriatric psychiatry.

Journal Article Curr Opin Psychiatry · July 2018 PURPOSE OF REVIEW: Academic recognition of the implications of religion/spirituality (R/S) for mental health is increasing, with a growing number of studies involving older adults. The present review provides an overview of these studies, highlighting the ... Full text Link to item Cite

Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies.

Journal Article Lancet · April 14, 2018 BACKGROUND: Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant ... Full text Link to item Cite

Advancing our diagnostic tools and treatment options for delirium.

Journal Article Int Psychogeriatr · April 2018 Delirium is one of the most prevalent and disabling conditions impacting older adults in hospitals and long-term care settings. The estimates of frequency of delirium in hospitals and nursing homes among older adults range widely, yet it is safe to assume ... Full text Link to item Cite

Geriatric Psychiatry.

Journal Article Psychiatr Clin North Am · March 2018 Full text Link to item Cite

Hearing Loss: The Silent Risk for Psychiatric Disorders in Late Life.

Journal Article Psychiatr Clin North Am · March 2018 Hearing loss is among the most frequent problems experienced by older adults, yet psychiatrists and other clinicians often ignore the problem as an aggravation rather than recognizing that the problem might benefit from appropriate hearing health care. Man ... Full text Link to item Cite

Battles Worth Fighting.

Journal Article J Am Geriatr Soc · March 2018 Full text Link to item Cite

Neuroendocrine Neoplasms of the Appendix: A Review of the Literature.

Journal Article Anticancer Res · February 2018 Appendiceal neuroendocrine neoplasms (ANENs) comprise rare tumors of the appendix, mainly affecting young populations and characterized by a rather favorable prognosis. The aim of this review was to summarize the current knowledge on these neoplasms, focus ... Full text Link to item Cite

Depression Among Older Adults: A 20-Year Update on Five Common Myths and Misconceptions.

Journal Article Am J Geriatr Psychiatry · January 2018 Is depression among older adults symptomatically different than younger adults? Is it more common or chronic or difficult to treat? Is depression in late life more likely to be attributed to psychological problems? Twenty-years ago, Dan Blazer, a pioneer k ... Full text Link to item Cite

Do We Ever Outlive Depression?

Journal Article Am J Geriatr Psychiatry · November 2017 Full text Link to item Cite

Bipolar Disorder and Dementia: Weighing the Evidence.

Journal Article Am J Geriatr Psychiatry · April 2017 Full text Link to item Cite

Cognitive Aging: What We Fear and What We Know.

Journal Article Perspect Biol Med · 2017 Advances in the scientific understanding of the aging brain have led to the concept of cognitive aging. Physicians lag in their understanding of cognitive aging, and the public fear of mental deterioration is disproportionate to its true risk. Understandin ... Full text Link to item Cite

Depression in Late Life: Review and Commentary

Chapter · January 1, 2017 Depression is perhaps the most frequent cause of emotional suffering in later life and significantly decreases quality of life in older adults. In recent years, the literature on late-life depression has exploded. Many gaps in our understanding of the outc ... Full text Cite

Age-Friendly Communities Initiative: Public Health Approach to Promoting Successful Aging.

Journal Article Am J Geriatr Psychiatry · December 2016 Older adults consistently prefer aging in place, which requires a high level of community support and services that are currently lacking. With a rapidly aging population, the present infrastructure for healthcare will prove even more inadequate to meet se ... Full text Link to item Cite

Hearing health care for adults: Priorities for improving access and affordability

Book · October 6, 2016 The loss of hearing - be it gradual or acute, mild or severe, present since birth or acquired in older age - can have significant effects on one's communication abilities, quality of life, social participation, and health. Despite this, many people with he ... Full text Cite

Do We Ever Escape the Consequences of Childhood Deprivation?

Journal Article Am J Geriatr Psychiatry · September 2016 Full text Link to item Cite

Cognitive Aging: What Every Geriatric Psychiatrist Should Know.

Journal Article Am J Geriatr Psychiatry · September 2016 The authors of this review both served on the Institute of Medicine Committee, which produced the report "Cognitive Aging: Progress in Understanding and Opportunities for Action." In this review, the authors summarize portions of the report that are especi ... Full text Link to item Cite

Heterogeneity in the three-year course of major depression among older adults.

Journal Article Int J Geriatr Psychiatry · July 2016 OBJECTIVE: The objective of this research was to identify distinct trajectories of recovery in older depressed patients in order to identify optimal samples and points for interventions. METHODS: The sample was 368 patients ages 60 years and older diagnose ... Full text Link to item Cite

Epidemiology of psychiatric illness

Chapter · January 1, 2016 The science of epidemiology has much to offer in assisting clinical investigators and practicing psychiatrists to place the work on inpatient units and outpatient clinics into context. Epidemiologists first emphasize the importance of case identification a ... Full text Cite

Cognitive aging: Progress in understanding and opportunities for action

Book · August 21, 2015 For most Americans, staying "mentally sharp" as they age is a very high priority. Declines in memory and decision-making abilities may trigger fears of Alzheimer's disease or other neurodegenerative diseases. However, cognitive aging is a natural process t ... Full text Cite

Meet our editorial board member

Journal Article Current Psychiatry Reviews · August 1, 2015 Full text Cite

Substance use disorders and co-morbidities among Asian Americans and Native Hawaiians/Pacific Islanders

Journal Article Psychological Medicine · February 12, 2015 Background Asian Americans (AAs) and Native Hawaiians/Pacific Islanders (NHs/PIs) are the fastest growing segments of the US population. However, their population sizes are small, and thus AAs and NHs/PIs are often aggregated into a single racial/ethnic gr ... Full text Open Access Cite

Substance use disorders and co-morbidities among Asian Americans and Native Hawaiians/Pacific Islanders.

Journal Article Psychol Med · February 2015 BACKGROUND: Asian Americans (AAs) and Native Hawaiians/Pacific Islanders (NHs/PIs) are the fastest growing segments of the US population. However, their population sizes are small, and thus AAs and NHs/PIs are often aggregated into a single racial/ethnic g ... Full text Open Access Link to item Cite

An unsubstantiated conclusion.

Journal Article Am J Geriatr Psychiatry · February 2015 Full text Link to item Cite

The new DSM-5 diagnosis of mild neurocognitive disorder and its relation to research in mild cognitive impairment.

Journal Article Aging Ment Health · January 2015 The Diagnostic Statistical Manual-5 (DSM-5) has included a category named the neurocognitive disorder which was formally known in DSM-IV as 'dementia, delirium, amnestic, and other cognitive disorders'. The DSM-5 distinguishes between 'mild' and 'major' ne ... Full text Link to item Cite

Depression and cognition in the elderly.

Journal Article Annu Rev Clin Psychol · 2015 This review provides an overview of the relationship between depression and cognition in the elderly, with an emphasis on psychotherapies and nonpharmacologic approaches. We first review the clinical presentation of late-life depression and comorbid cognit ... Full text Link to item Cite

Nonmedical stimulant use among young Asian-Americans, Native Hawaiians/Pacific Islanders, and mixed-race individuals aged 12-34 years in the United States.

Journal Article J Psychiatr Res · December 2014 There are concerns over nonmedical use of prescription stimulants among youths, but little is known about the extent of use among young Asian-Americans, Native Hawaiians/Pacific Islanders (NHs/PIs), and mixed-race individuals-the fastest growing segments o ... Full text Open Access Link to item Cite

Classifying neurocognitive disorders: the DSM-5 approach.

Journal Article Nat Rev Neurol · November 2014 Neurocognitive disorders--including delirium, mild cognitive impairment and dementia--are characterized by decline from a previously attained level of cognitive functioning. These disorders have diverse clinical characteristics and aetiologies, with Alzhei ... Full text Link to item Cite

Risk factors for suicide among older adults with cancer.

Journal Article Aging Ment Health · September 2014 OBJECTIVE: To determine whether the increased risk of suicide for individuals with cancer may be explained by functional limitations, lack of social support, or other factors. METHOD: In this population-based case-control study, interviews of primary infor ... Full text Link to item Cite

Substance abuse among older adults.

Journal Article Clin Geriatr Med · August 2014 Although the myth that older adults do not use mood-altering substances persists, evidence suggests that substance use among older adults has been underidentified for decades. The baby boom generation is unique in its exposure to, attitudes toward, and pre ... Full text Link to item Cite

Inflammation and Coagulation as Mediators in the Relationships Between Religious Attendance and Functional Limitations in Older Adults.

Journal Article J Aging Health · June 2014 OBJECTIVE: The aim of this study was to examine inflammation and coagulation, which are positively linked to disability and inversely linked to increased religious attendance, as mediators in the cross-sectional relationships between religious attendance a ... Full text Link to item Cite

Dysphoria and anhedonia as risk factors for disability or death in older persons: implications for the assessment of geriatric depression.

Journal Article Am J Geriatr Psychiatry · June 2014 OBJECTIVES: Either dysphoria (sadness) or anhedonia (loss of interest in usually pleasurable activities) is required for a diagnosis of major depression. Although major depression is a known risk factor for disability in older persons, few studies have exa ... Full text Link to item Cite

Long-term cumulative depressive symptom burden and risk of cognitive decline and dementia among very old women.

Journal Article J Gerontol A Biol Sci Med Sci · May 2014 BACKGROUND: Depressive symptoms and cognitive outcomes are strongly interrelated. Despite that rates of depressive symptoms fluctuate during late life, little is known about the impact of long-term cumulative depressive symptom burden on cognitive decline ... Full text Link to item Cite

Substance use disorders and psychiatric comorbidity in mid and later life: a review.

Journal Article Int J Epidemiol · April 2014 BACKGROUND: Globally, adults aged 65 years or older will increase from 516 million in 2009 to an estimated 1.53 billion in 2050. Due to substance use at earlier ages that may continue into later life, and ageing-related changes in medical conditions, older ... Full text Open Access Link to item Cite

Glycated hemoglobin measurement and prediction of cardiovascular disease.

Journal Article JAMA · March 26, 2014 IMPORTANCE: The value of measuring levels of glycated hemoglobin (HbA1c) for the prediction of first cardiovascular events is uncertain. OBJECTIVE: To determine whether adding information on HbA1c values to conventional cardiovascular risk factors is assoc ... Full text Link to item Cite

Recovery on higher ground: Spirituality in the treatment of substance abuse

Journal Article Current Psychiatry · February 1, 2014 Cite

Diagnostic criteria for vascular cognitive disorders: a VASCOG statement.

Journal Article Alzheimer Dis Assoc Disord · 2014 BACKGROUND: Several sets of diagnostic criteria have been published for vascular dementia since the 1960s. The continuing ambiguity in vascular dementia definition warrants a critical reexamination. METHODS: Participants at a special symposium of the Inter ... Full text Link to item Cite

Progress in delirium.

Journal Article Am J Geriatr Psychiatry · December 2013 Full text Link to item Cite

Why gerontologists should care about empirical research on religion and health: transdisciplinary perspectives.

Journal Article Gerontologist · December 2013 A large volume of empirical research has accumulated on the relationship between religion/spirituality (R/S) and health since the year 2000, much of it involving older adults. The purpose of this article is to discuss how this body of existing research fin ... Full text Link to item Cite

Illicit and nonmedical drug use among Asian Americans, Native Hawaiians/Pacific Islanders, and mixed-race individuals.

Journal Article Drug Alcohol Depend · December 1, 2013 BACKGROUND: The racial/ethnic composition of the United States is shifting rapidly, with non-Hispanic Asian-Americans, Native Hawaiians/Pacific Islanders (NHs/PIs), and mixed-race individuals the fastest growing segments of the population. We determined ne ... Full text Open Access Link to item Cite

Comorbid substance use disorders with other Axis I and II mental disorders among treatment-seeking Asian Americans, Native Hawaiians/Pacific Islanders, and mixed-race people.

Journal Article J Psychiatr Res · December 2013 Little is known about behavioral healthcare needs of Asian Americans (AAs), Native Hawaiians/Pacific Islanders (NHs/PIs), and mixed-race people (MRs)-the fastest growing segments of the U.S. population. We examined substance use disorder (SUD) prevalences ... Full text Open Access Link to item Cite

The prevalence and distribution of major depression in a national community sample: The national comorbidity survey

Chapter · October 15, 2013 Objective: Major depression is a frequent and disabling psychiatric disorder in the United States. This report examines the prevalence and risk factor profile of both pure and comorbid major depression according to data from the National Comorbidity Survey ... Cite

MRI-defined vascular depression

Chapter · October 15, 2013 OBJECTIVE: The authors' goal was to characterize the clinical and demographic features of vascular depression. METHOD: They classified 89 depressed patients into two groups-those with vascular (N = 32) and nonvascular (N = 57) depression-on the basis of ex ... Cite

Latent subtypes of depression in a community sample of older adults: can depression clusters predict future depression trajectories?

Journal Article J Psychiatr Res · October 2013 Identifying sources of heterogeneity in late life depression remains an important focus of psychiatric investigation. Community samples are particularly informative since many older adults have clinically significant depressive symptoms but fail to meet cr ... Full text Link to item Cite

Tobacco use among Asian Americans, Native Hawaiians/Pacific Islanders, and mixed-race individuals: 2002-2010.

Journal Article Drug Alcohol Depend · September 1, 2013 BACKGROUND: Non-Hispanic Asian Americans, Native Hawaiians/Pacific Islanders (NHs/PIs), and mixed-race individuals are the fastest growing segments of the US population. We examined prevalences and correlates of tobacco use among these understudied groups. ... Full text Open Access Link to item Cite

Neurocognitive disorders in DSM-5.

Journal Article Am J Psychiatry · June 2013 Full text Link to item Cite

Trajectory classes of body mass index in a representative elderly community sample.

Journal Article J Gerontol A Biol Sci Med Sci · June 2013 BACKGROUND: It is unclear whether distinct weight-related trajectory classes, differing in course, demographics, and health characteristics, exist in the elderly population. METHODS: Data came from the 10-year (1986-1996) Duke Established Populations for E ... Full text Link to item Cite

Using electronic health records data to assess comorbidities of substance use and psychiatric diagnoses and treatment settings among adults.

Journal Article J Psychiatr Res · April 2013 OBJECTIVE: To examine prevalences of substance use disorders (SUD) and comprehensive patterns of comorbidities among psychiatric patients ages 18-64 years (N = 40,099) in an electronic health records (EHR) database. METHOD: DSM-IV diagnoses among psychiatr ... Full text Open Access Link to item Cite

Health consequences of familial longevity influence among the Chinese elderly.

Journal Article J Gerontol A Biol Sci Med Sci · April 2013 BACKGROUND: A comparative analysis between centenarians' children and neighborhood controls is an efficient approach to learn how familial longevity influence and its interaction with environmental factors affect healthy aging. Yet, there are few extant st ... Full text Link to item Cite

Systematic review of the effectiveness of pharmacologic interventions to improve quality of life and well-being in people with dementia.

Journal Article Am J Geriatr Psychiatry · February 2013 OBJECTIVE: To review systematically, for the first time, the effectiveness of all pharmacologic interventions to improve quality of life and well-being in people with dementia. DESIGN: Systematic review and meta-analysis. METHODS: We systematically reviewe ... Full text Link to item Cite

Foreword

Chapter · January 1, 2013 Full text Cite

The course of depression in the elderly: A longitudinal community-based study in australia

Journal Article Journal of the American Geriatrics Society · January 1, 2013 Full text Cite

The age-specific quantitative effects of metabolic risk factors on cardiovascular diseases and diabetes: a pooled analysis.

Journal Article PLoS One · 2013 BACKGROUND: The effects of systolic blood pressure (SBP), serum total cholesterol (TC), fasting plasma glucose (FPG), and body mass index (BMI) on the risk of cardiovascular diseases (CVD) have been established in epidemiological studies, but consistent es ... Full text Link to item Cite

Evaluating brief screeners to discriminate between drug use disorders in a sample of treatment-seeking adults.

Journal Article Gen Hosp Psychiatry · 2013 OBJECTIVE: The objective was to identify a potential core set of brief screeners for the detection of individuals with a substance use disorder (SUD) in medical settings. METHOD: Data were from two multisite studies that evaluated stimulant use outcomes of ... Full text Open Access Link to item Cite

Life satisfaction and preterm birth among urban black women: findings from the Baltimore preterm birth study.

Journal Article Ann Epidemiol · November 2012 PURPOSE: Preterm birth (PTB) is a major problem in the United States, and black women have greater risk of PTB than white women. The etiology of PTB and the racial disparity in preterm outcomes are poorly understood. Diminished life satisfaction is associa ... Full text Link to item Cite

The mental health and substance use workforce for older adults: In whose hands?

Book · October 26, 2012 At least 5.6 million to 8 million--nearly one in five--older adults in America have one or more mental health and substance use conditions, which present unique challenges for their care. With the number of adults age 65 and older projected to soar from 40 ... Full text Cite

Twenty-year depressive trajectories among older women.

Journal Article Arch Gen Psychiatry · October 2012 CONTEXT: Despite the frequent occurrence of depressive symptoms among older adults, especially women, little is known about the long-term course of late-life depressive symptoms. OBJECTIVE: To characterize the natural course of depressive symptoms among ol ... Full text Link to item Cite

The complex association between religious activities and functional limitations in older adults.

Journal Article Gerontologist · October 2012 PURPOSE OF THE STUDY: To examine the longitudinal associations between 3 dimensions of religious involvement-religious attendance, use of religious media, and private religious activities-and 3 domains of functional status-limitations in basic activities o ... Full text Link to item Cite

Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis.

Journal Article Int J Epidemiol · October 2012 BACKGROUND: The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain. METHODS: We calculated hazard ratios (HRs) for height, assessed in ... Full text Link to item Cite

Alcohol and drug use disorders among adults in emergency department settings in the United States.

Journal Article Ann Emerg Med · August 2012 STUDY OBJECTIVE: Improving identification and treatment for substance use disorders is a national priority, but data about various drug use disorders encountered in emergency departments (EDs) are lacking. We examine past-year substance use and substance u ... Full text Open Access Link to item Cite

Maternal prenatal depressive symptoms, nicotine addiction, and smoking-related knowledge, attitudes, beliefs, and behaviors.

Journal Article Matern Child Health J · July 2012 Maternal smoking is a key preventable cause of poor pregnancy outcomes, such as low birthweight. In many areas of the United States, including Eastern North Carolina, rates of prenatal smoking are high. Prenatal depressive symptoms are associated with mate ... Full text Link to item Cite

Age differences in symptom expression in patients with major depression.

Journal Article Int J Geriatr Psychiatry · June 2012 Featured Publication OBJECTIVE: The aim of the study was to compare symptom expression in primarily middle-aged (<60) and older (60+) patients who were depressed and determine if symptom profiles differed by age. METHODS: Patients diagnosed with major depression (N = 664) were ... Full text Link to item Cite

Trajectory classes of depressive symptoms in a community sample of older adults.

Journal Article Acta Psychiatr Scand · June 2012 Featured Publication OBJECTIVE: To identify trajectories of depressive symptoms in older community residents. METHOD: Depressive symptomatology, based on a modified Center for Epidemiological Studies-Depression scale, was obtained at years 0, 3, 6, and 10, in the Duke Establis ... Full text Link to item Cite

A dimensional approach to understanding severity estimates and risk correlates of marijuana abuse and dependence in adults.

Journal Article Int J Methods Psychiatr Res · June 2012 While item response theory (IRT) research shows a latent severity trait underlying response patterns of substance abuse and dependence symptoms, little is known about IRT-based severity estimates in relation to clinically relevant measures. In response to ... Full text Open Access Link to item Cite

The association between waist circumference and risk of mortality considering body mass index in 65- to 74-year-olds: a meta-analysis of 29 cohorts involving more than 58 000 elderly persons.

Journal Article Int J Epidemiol · June 2012 BACKGROUND: For the elderly, the association between waist circumference (WC) and mortality considering body mass index (BMI) remains unclear, and thereby also the evidence base for using these anthropometric measures in clinical practice. This meta-analys ... Full text Link to item Cite

Systematic review of the effectiveness of non-pharmacological interventions to improve quality of life of people with dementia.

Journal Article Int Psychogeriatr · June 2012 BACKGROUND: People with dementia report lower quality of life, but we know little about what interventions might improve it. METHODS: We systematically reviewed 20 randomized controlled trials reporting the effectiveness of non-pharmacological intervention ... Full text Link to item Cite

Evidence for the diagnostic criteria of delirium: an update.

Journal Article Curr Opin Psychiatry · May 2012 PURPOSE OF REVIEW: Since the publication of DSM-III in 1980, the essential criteria for delirium have been reduced progressively through DSM-III-R to DSM-IV. As the field moves toward DSM-V and ICD-11, new data can shed light on the nosological changes tha ... Full text Link to item Cite

Depression in Later Life: Aetiology, Epidemiology, Assessment, Diagnosis and Treatment

Journal Article · March 12, 2012 Depression is the most frequent cause of emotional suffering in later life and is associated with significant losses in one's quality of life, often occurring in the context of physical or cognitive impairment. Several theories of depression in the elderly ... Full text Cite

Alcohol and drug dependence symptom items as brief screeners for substance use disorders: results from the Clinical Trials Network.

Journal Article J Psychiatr Res · March 2012 Featured Publication AIM: To address an urgent need for screening of substance use problems in medical settings, we examined substance-specific dependence criteria as potential brief screeners for the detection of patients with a substance use disorder (SUD). METHODS: The samp ... Full text Open Access Link to item Cite

Comparison of outcomes and the use of multimodality therapy in young and elderly people undergoing surgical resection of pancreatic cancer.

Journal Article J Am Geriatr Soc · February 2012 Featured Publication OBJECTIVES: To compare outcomes and the use of multimodality therapy in young and elderly people with pancreatic cancer undergoing surgical resection. DESIGN: Retrospective, single-institution study. SETTING: National Cancer Institute/National Comprehensiv ... Full text Link to item Cite

A framework for quantifying net benefits of alternative prognostic models.

Journal Article Stat Med · January 30, 2012 New prognostic models are traditionally evaluated using measures of discrimination and risk reclassification, but these do not take full account of the clinical and health economic context. We propose a framework for comparing prognostic models by quantify ... Full text Link to item Cite

Systematic review of the effectiveness of pharmacologic interventions to improve quality of life and well-being in people with dementia

Journal Article American Journal of Geriatric Psychiatry · January 12, 2012 OBJECTIVE: To review systematically, for the first time, the effectiveness of all pharmacologic interventions to improve quality of life and well-being in people with dementia. DESIGN: Systematic review and meta-analysis. METHODS: We systematically reviewe ... Full text Cite

The age of melancholy: “Major depression” and its social origins

Journal Article The Age of Melancholy: "Major Depression" and its Social Origins · January 1, 2012 Depression has become the most frequently diagnosed chronic mental illness, and is a disability encountered almost daily by mental health professionals of all trades. “Major Depression” is a medical disease, which some would argue has reached epidemic prop ... Full text Cite

Patterns of tobacco use and tobacco-related psychiatric morbidity and substance use among middle-aged and older adults in the United States.

Journal Article Aging Ment Health · 2012 OBJECTIVES: To examine prevalence of tobacco use and identify psychiatric symptoms and substance use correlates of tobacco use comparing adults 50-64 years of age with those 65+ years of age (N = 10,891). METHODS: Data were from the 2008-2009 US National S ... Full text Open Access Link to item Cite

Treatment use and barriers among adolescents with prescription opioid use disorders.

Journal Article Addict Behav · December 2011 Featured Publication BACKGROUND: This study examined national trends, patterns, correlates, and barriers to substance abuse treatment use by adolescents aged 12-17 years who met at least one of the past-year criteria for prescription opioid abuse or dependence (N=1788). METHOD ... Full text Open Access Link to item Cite

Substance use disorders and comorbid Axis I and II psychiatric disorders among young psychiatric patients: findings from a large electronic health records database.

Journal Article J Psychiatr Res · November 2011 This study examined the prevalence of substance use disorders (SUDs) among psychiatric patients aged 2-17 years in an electronic health records database (N=11,457) and determined patterns of comorbid diagnoses among patients with a SUD to inform emerging c ... Full text Open Access Link to item Cite

Racial/ethnic variations in substance-related disorders among adolescents in the United States.

Journal Article Arch Gen Psychiatry · November 2011 Featured Publication CONTEXT: While young racial/ethnic groups are the fastest growing population in the United States, data about substance-related disorders among adolescents of various racial/ethnic backgrounds are lacking. OBJECTIVE: To examine the magnitude of past-year D ... Full text Open Access Link to item Cite

Use of item response theory and latent class analysis to link poly-substance use disorders with addiction severity, HIV risk, and quality of life among opioid-dependent patients in the Clinical Trials Network.

Journal Article Drug Alcohol Depend · November 1, 2011 Featured Publication BACKGROUND: This study applied item response theory (IRT) and latent class analysis (LCA) procedures to examine the dimensionality and heterogeneity of comorbid substance use disorders (SUDs) and explored their utility for standard clinical assessments, in ... Full text Open Access Link to item Cite

When a chance to cut is not a chance to cure: a future for palliative surgery?

Other Ann Surg Oncol · November 2011 Featured Publication In the context of healthcare reform, Surgery stands at a critical juncture. Attempting to rein in healthcare spending, legislators and payers can be expected to closely examine the legitimacy and necessity of a variety of medical treatments, including surg ... Full text Link to item Cite

Heterogeneity in symptom profiles among older adults diagnosed with major depression.

Journal Article Int Psychogeriatr · August 2011 Featured Publication BACKGROUND: Late-life depression may be undiagnosed due to symptom expression. These analyses explore the structure of depressive symptoms in older patients diagnosed with major depression by identifying clusters of patients based on their symptom profiles ... Full text Link to item Cite

The epidemiology of alcohol use disorders and subthreshold dependence in a middle-aged and elderly community sample.

Journal Article Am J Geriatr Psychiatry · August 2011 Featured Publication OBJECTIVE: To estimate 1-year prevalence and correlates of alcohol abuse, dependence, and subthreshold dependence (diagnostic orphans) among middle-aged and elderly persons in the United States. DESIGN: 2005-2007 National Surveys on Drug Use and Health. ME ... Full text Open Access Link to item Cite

A systematic review of treatments for refractory depression in older people.

Journal Article Am J Psychiatry · July 2011 OBJECTIVE: The authors systematically reviewed the management of treatment-refractory depression in older people (defined as age 55 or older). METHOD: The authors conducted an electronic database search and reviewed the 14 articles that fit predetermined c ... Full text Link to item Cite

Differences in onset and abuse/dependence episodes between prescription opioids and heroin: results from the National Epidemiologic Survey on Alcohol and Related Conditions.

Journal Article Subst Abuse Rehabil · May 2011 Featured Publication OBJECTIVES: To examine patterns of onset and abuse/dependence episodes of prescription opioid (PO) and heroin use disorders in a national sample of adults, and to explore differences by gender and substance abuse treatment status. METHODS: Analyses of data ... Full text Open Access Link to item Cite

Epidemiology and Geriatric Psychiatry

Journal Article · April 19, 2011 Full text Cite

Illicit and nonmedical drug use among older adults: a review.

Journal Article J Aging Health · April 2011 OBJECTIVE: Substance abuse among older adults is a looming public health concern. The number of Americans aged 50+ years with a substance use disorder is projected to double from 2.8 million in 2002-2006 to 5.7 million in 2020. The authors provide a review ... Full text Open Access Link to item Cite

Recent national trends in Salvia divinorum use and substance-use disorders among recent and former Salvia divinorum users compared with nonusers.

Journal Article Subst Abuse Rehabil · April 2011 Featured Publication CONTEXT: Media and scientific reports have indicated an increase in recreational use of Salvia divinorum. Epidemiological data are lacking on the trends, prevalence, and correlates of S. divinorum use in large representative samples, as well as the extent ... Full text Open Access Link to item Cite

Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies.

Journal Article Lancet · March 26, 2011 BACKGROUND: Guidelines differ about the value of assessment of adiposity measures for cardiovascular disease risk prediction when information is available for other risk factors. We studied the separate and combined associations of body-mass index (BMI), w ... Full text Link to item Cite

Abuse and dependence on prescription opioids in adults: a mixture categorical and dimensional approach to diagnostic classification.

Journal Article Psychol Med · March 2011 Featured Publication BACKGROUND: For the emerging DSM-V, it has been recommended that dimensional and categorical methods be used simultaneously in diagnostic classification; however, little is known about this combined approach for abuse and dependence. METHOD: Using data (n= ... Full text Open Access Link to item Cite

How do prescription opioid users differ from users of heroin or other drugs in psychopathology: results from the National Epidemiologic Survey on Alcohol and Related Conditions.

Journal Article J Addict Med · March 2011 Featured Publication OBJECTIVES: To study substance use and psychiatric disorders among prescription opioid users, heroin users, and non-opioid drug users in a national sample of adults. METHODS: Analyses of data from the 2001-2002 National Epidemiologic Survey on Alcohol and ... Full text Open Access Link to item Cite

Classification of neurocognitive disorders in DSM-5: a work in progress.

Journal Article Am J Geriatr Psychiatry · March 2011 Featured Publication Full text Link to item Cite

Depressive symptoms, substance use, and HIV-related high-risk behaviors among opioid-dependent individuals: results from the Clinical Trials Network.

Journal Article Subst Use Misuse · 2011 Featured Publication The sample included 343 opioid-dependent adults enrolled in two national multisite studies of the National Drug Abuse Treatment Clinical Trials Network (CTN001-002). Opioid-dependent individuals were recruited from 12 sites across the United States from Ja ... Full text Open Access Link to item Cite

Co-occurring amphetamine use and associated medical and psychiatric comorbidity among opioid-dependent adults: results from the Clinical Trials Network.

Journal Article Subst Abuse Rehabil · January 1, 2011 BACKGROUND: In response to the rising rate of treatment admissions related to illicit use of amphetamines (eg, methamphetamine), we examined the prevalence of amphetamine use among treatment-seeking, opioid-dependent adults, explored whether amphetamine us ... Full text Open Access Link to item Cite

Why John wasn't healed by prayer: perspectives across disciplines.

Journal Article Int J Psychiatry Med · 2011 Patients and family members often turn to prayer in response to serious, life-threatening illness. Prayer for a miraculous cure is often the request. While prayer can keep hope alive, it may also promote unrealistic expectations that fuel demands for life- ... Full text Link to item Cite

Nosology and Classification of Mood Disorders

Journal Article · December 2, 2010 Mood disorders in DSM-IV and ICD-10 are classified into a number of different categories, including manic episode, depressive episode, bipolar disorder, unipolar disorder, dysthymia, adjustment disorder with depressed mood, and depressed mood associated wi ... Full text Cite

Preface to Second Edition

Journal Article Principles and Practice of Geriatric Psychiatry: Third Edition · December 2, 2010 Full text Cite

Gender and racial/ethnic differences in addiction severity, HIV risk, and quality of life among adults in opioid detoxification: results from the National Drug Abuse Treatment Clinical Trials Network.

Journal Article Subst Abuse Rehabil · December 2010 Featured Publication PURPOSE: Detoxification often serves as an initial contact for treatment and represents an opportunity for engaging patients in aftercare to prevent relapse. However, there is limited information concerning clinical profiles of individuals seeking detoxifi ... Full text Open Access Link to item Cite

Subtypes of nonmedical opioid users: results from the national epidemiologic survey on alcohol and related conditions.

Journal Article Drug Alcohol Depend · November 1, 2010 Featured Publication AIMS: To identify subtypes of nonmedical opioid users, gender variations in psychiatric disorders, and quality of life in a representative sample of adults. METHODS: Analyses of data from the 2001-2002 National Epidemiologic Survey on Alcohol and Related C ... Full text Open Access Link to item Cite

Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiological studies.

Journal Article Int J Epidemiol · October 2010 BACKGROUND: Meta-analysis of individual participant time-to-event data from multiple prospective epidemiological studies enables detailed investigation of exposure-risk relationships, but involves a number of analytical challenges. METHODS: This article de ... Full text Link to item Cite

Shortness of breath as a predictor of depressive symptoms in a community sample of older adults.

Journal Article Int J Geriatr Psychiatry · October 2010 Featured Publication OBJECTIVES: Physical symptoms are known to be associated with late life depression both cross-sectionally and over time. We attempted to determine if self-reported shortness of breath (SoB) is associated with depressive symptoms at long-term (3-year) follo ... Full text Link to item Cite

Accuracy of self-reported height and weight in a community-based sample of older African Americans and whites.

Journal Article J Gerontol A Biol Sci Med Sci · October 2010 Featured Publication BACKGROUND: To ascertain accuracy of self-reported height, weight (and hence body mass index) in African American and white women and men older than 70 years of age. METHOD: The sample consisted of cognitively intact participants at the third in-person wav ... Full text Link to item Cite

Expert consensus on characteristics of wisdom: a Delphi method study.

Journal Article Gerontologist · October 2010 PURPOSE: Wisdom has received increasing attention in empirical research in recent years, especially in gerontology and psychology, but consistent definitions of wisdom remain elusive. We sought to better characterize this concept via an expert consensus pa ... Full text Link to item Cite

Book Review: The Rise and Fall of the Biopsychosocial Model: Reconciling Art and Science in Psychiatry

Journal Article The International Journal of Psychiatry in Medicine · September 2010 Full text Cite

APOE epsilon4 allele carriers: Biological, psychological, and social variables associated with cognitive impairment.

Journal Article Aging Ment Health · August 2010 Featured Publication OBJECTIVE: The apolipoprotein (APOE) epsilon4 allele genotype is a risk factor for dementia, but not all people with the APOE epsilon4 allele develop cognitive impairment (CI). Among participants with the APOE epsilon4 allele (N = 664), we identified biolo ... Full text Link to item Cite

Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects.

Journal Article Biochim Biophys Acta · August 2010 Featured Publication The neurosteroid allopregnanolone has pronounced neuroprotective actions, increases myelination, and enhances neurogenesis. Evidence suggests that allopregnanolone dysregulation may play a role in the pathophysiology of Alzheimer's disease (AD) and other n ... Full text Link to item Cite

Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies.

Journal Article Lancet · June 26, 2010 BACKGROUND: Uncertainties persist about the magnitude of associations of diabetes mellitus and fasting glucose concentration with risk of coronary heart disease and major stroke subtypes. We aimed to quantify these associations for a wide range of circumst ... Full text Link to item Cite

Using a latent variable approach to inform gender and racial/ethnic differences in cocaine dependence: a National Drug Abuse Treatment Clinical Trials Network study.

Journal Article J Subst Abuse Treat · June 2010 Featured Publication This study applies a latent variable approach to examine gender and racial/ethnic differences in cocaine dependence, to determine the presence of differential item functioning (DIF) or item-response bias to diagnostic questions of cocaine dependence, and t ... Full text Open Access Link to item Cite

Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies.

Journal Article Lancet · May 8, 2010 BACKGROUND: Whether triglyceride-mediated pathways are causally relevant to coronary heart disease is uncertain. We studied a genetic variant that regulates triglyceride concentration to help judge likelihood of causality. METHODS: We assessed the -1131T>C ... Full text Link to item Cite

Problems meeting basic needs moderate the association between the APOE epsilon4 allele and cognitive decline.

Journal Article Aging Ment Health · March 2010 Featured Publication OBJECTIVES: The ApolipoproteinE epsilon4 (APOE epsilon4) allele influences cognitive decline (CD) in some but not in all individuals. The purpose of this study was to investigate whether problems meeting basic needs (BN) (e.g., having enough money to meet ... Full text Link to item Cite

An item response theory analysis of DSM-IV criteria for hallucinogen abuse and dependence in adolescents.

Journal Article Addict Behav · March 2010 Featured Publication AIM: This study applied both item response theory (IRT) and multiple indicators-multiple causes (MIMIC) methods to evaluate item-level psychometric properties of diagnostic questions for hallucinogen use disorders (HUDs), differential item functioning (DIF ... Full text Open Access Link to item Cite

Depressive symptoms in middle age and the development of later-life functional limitations: the long-term effect of depressive symptoms.

Journal Article J Am Geriatr Soc · March 2010 Featured Publication OBJECTIVES: To determine whether middle-aged persons with depressive symptoms are at higher risk for developing activity of daily living (ADL) and mobility limitations as they advance into older age than those without. DESIGN: Prospective cohort study. SET ... Full text Link to item Cite

Protection from late life depression.

Journal Article Int Psychogeriatr · March 2010 Featured Publication Full text Link to item Cite

C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis.

Journal Article Lancet · January 9, 2010 BACKGROUND: Associations of C-reactive protein (CRP) concentration with risk of major diseases can best be assessed by long-term prospective follow-up of large numbers of people. We assessed the associations of CRP concentration with risk of vascular and n ... Full text Link to item Cite

Genetic testing for Alzheimer's and long-term care insurance.

Journal Article Health Aff (Millwood) · 2010 Featured Publication A genetic marker known as apolipoprotein E provides a clear signal of a person's risk of developing Alzheimer's disease and thus that person's future need for long-term care. People who find that they have the variant of the trait that increases Alzheimer' ... Full text Link to item Cite

Trajectories of mobility and IADL function in older patients diagnosed with major depression.

Journal Article Int J Geriatr Psychiatry · January 2010 Featured Publication OBJECTIVE: Research has shown an association between depression and functional limitations in older adults. Our aim was to explore the latent traits of trajectories of limitations in mobility and instrumental activities of daily living (IADL) tasks in a sa ... Full text Link to item Cite

The epidemiology of alcohol use disorders and subthreshold dependence in a middle-aged and elderly community sample

Journal Article American Journal of Geriatric Psychiatry · 2010 OBJECTIVE: To estimate 1-year prevalence and correlates of alcohol abuse, dependence, and subthreshold dependence (diagnostic orphans) among middle-aged and elderly persons in the United States. DESIGN: 2005-2007 National Surveys on Drug Use and Health. ME ... Full text Open Access Cite

Geriatric Psychiatry

Journal Article Psychiatric Annals · January 1, 2010 Full text Cite

The origins of late-life depression

Journal Article Psychiatric Annals · January 1, 2010 Full text Cite

A prospective study of depression following combat deployment in support of the wars in Iraq and Afghanistan.

Journal Article Am J Public Health · January 2010 OBJECTIVE: We investigated relations between deployment and new-onset depression among US service members recently deployed to the wars in Iraq and Afghanistan. METHODS: We included 40 219 Millennium Cohort Study participants who completed baseline and fol ... Full text Link to item Cite

Drs. Blazer and Wu Reply.

Journal Article Am J Psychiatry · January 2010 Full text Open Access Link to item Cite

Religious attendance reduces cognitive decline among older women with high levels of depressive symptoms.

Journal Article J Gerontol A Biol Sci Med Sci · December 2009 Featured Publication BACKGROUND: There is growing evidence that regular attendance at religious functions is associated with less cognitive decline (CD). However, little research has investigated factors that may moderate the religious attendance-CD relationship. The present s ... Full text Link to item Cite

Major lipids, apolipoproteins, and risk of vascular disease.

Journal Article JAMA · November 11, 2009 CONTEXT: Associations of major lipids and apolipoproteins with the risk of vascular disease have not been reliably quantified. OBJECTIVE: To assess major lipids and apolipoproteins in vascular risk. DESIGN, SETTING, AND PARTICIPANTS: Individual records wer ... Full text Link to item Cite

The complex relationship between depressive symptoms and functional limitations in community-dwelling older adults: the impact of subthreshold depression.

Journal Article Psychol Med · October 2009 Featured Publication BACKGROUND: Depressive symptoms above screening thresholds have been shown to predict functional decline in older adults. Less is known about the impact of subthreshold depression, and whether more symptoms confer significantly greater risk compared to few ... Full text Link to item Cite

The epidemiology of at-risk and binge drinking among middle-aged and elderly community adults: National Survey on Drug Use and Health.

Journal Article Am J Psychiatry · October 2009 Featured Publication OBJECTIVE: The purpose of this article was to estimate the prevalence, distribution, and correlates of at-risk alcohol use (especially binge drinking) among middle-aged and elderly persons in the United States and to compare at-risk alcohol use between wom ... Full text Open Access Link to item Cite

Hallucinogen-related disorders in a national sample of adolescents: the influence of ecstasy/MDMA use.

Journal Article Drug Alcohol Depend · September 1, 2009 AIMS: To present the prevalence and correlates of hallucinogen use disorders (HUDs: abuse or dependence) and subthreshold dependence. METHODS: The study sample included adolescents aged 12-17 years (N=55,286) who participated in the National Survey on Drug ... Full text Open Access Link to item Cite

Identifying a national death index match.

Journal Article Am J Epidemiol · August 15, 2009 Featured Publication Data from the National Death Index (NDI) are frequently used to determine survival status in epidemiologic or clinical studies. On the basis of selected information submitted by the investigator, NDI returns a file containing a set of candidate matches. Al ... Full text Link to item Cite

The construct and measurement equivalence of cocaine and opioid dependences: a National Drug Abuse Treatment Clinical Trials Network (CTN) study.

Journal Article Drug Alcohol Depend · August 1, 2009 Featured Publication INTRODUCTION: Although DSM-IV criteria are widely used in making diagnoses of substance use disorders, gaps exist regarding diagnosis classification, use of dependence criteria, and effects of measurement bias on diagnosis assessment. We examined the const ... Full text Open Access Link to item Cite

The high prevalence of substance use disorders among recent MDMA users compared with other drug users: Implications for intervention.

Journal Article Addict Behav · August 2009 Featured Publication AIM: In light of the resurgence in MDMA use and its association with polysubstance use, we investigated the 12-month prevalence of substance use disorders (SUDs) among adult MDMA users to determine whether they are at risk of other drug-related problems th ... Full text Open Access Link to item Cite

Association of MDMA/ecstasy and other substance use with self-reported sexually transmitted diseases among college-aged adults: a national study.

Journal Article Public Health · August 2009 Featured Publication OBJECTIVES: MDMA/ecstasy use among college students has increased and reportedly leads to risky sexual behaviours. However, little is known about its association with sexually transmitted diseases (STDs). To evaluate this public health concern, this study ... Full text Open Access Link to item Cite

Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality.

Journal Article JAMA · July 22, 2009 CONTEXT: Circulating concentration of lipoprotein(a) (Lp[a]), a large glycoprotein attached to a low-density lipoprotein-like particle, may be associated with risk of coronary heart disease (CHD) and stroke. OBJECTIVE: To assess the relationship of Lp(a) c ... Full text Link to item Cite

Recognition and Prevention of Major Mental and Substance Use Disorders

Journal Article The Journal of Clinical Psychiatry · July 15, 2009 Full text Cite

Nonprescription use of pain relievers by middle-aged and elderly community-living adults: National Survey on Drug Use and Health.

Journal Article J Am Geriatr Soc · July 2009 Featured Publication OBJECTIVES: To estimate the frequency, distribution, and correlates of nonprescription use of pain relievers by middle-aged and elderly persons in the United States. DESIGN: Cross-sectional data analysis of a national community survey. SETTING: The 2005 an ... Full text Open Access Link to item Cite

Clinical outcomes of molecularly confirmed clear cell sarcoma from a single institution and in comparison with data from the Surveillance, Epidemiology, and End Results registry.

Journal Article Cancer · July 1, 2009 Featured Publication BACKGROUND: The authors compared disease-specific survival (DSS) in stage-specific subgroups of patients with clear cell sarcoma, including those with lymph node metastases (N1M0) and those with distant metastases (N0M1). METHODS: Clinical data regarding s ... Full text Link to item Cite

Construct and differential item functioning in the assessment of prescription opioid use disorders among American adolescents.

Journal Article J Am Acad Child Adolesc Psychiatry · May 2009 Featured Publication OBJECTIVE: To examine the psychometric properties of diagnostic criteria for prescription analgesic opioid use disorders (OUDs) and to identify background predictors of a latent continuum for OUD liability. METHOD: Data were drawn from the adolescent sampl ... Full text Open Access Link to item Cite

Profiles of depressive symptoms in older adults diagnosed with major depression: latent cluster analysis.

Journal Article Am J Geriatr Psychiatry · May 2009 Featured Publication OBJECTIVE: To explore the underlying structure of symptom presentation in older adults with major depression by identifying homogeneous clusters of individuals based on symptom profiles. DESIGN: Secondary data analysis using latent class cluster analysis. ... Full text Link to item Cite

An item response theory modeling of alcohol and marijuana dependences: a National Drug Abuse Treatment Clinical Trials Network study.

Journal Article J Stud Alcohol Drugs · May 2009 Featured Publication OBJECTIVE: The aim of this study was to examine psychometric properties of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), diagnostics criteria for alcohol and marijuana dependences among 462 alcohol users and 311 mariju ... Full text Open Access Link to item Cite

Smoking cessation behavior in older adults by race and gender: the role of health problems and psychological distress.

Journal Article Nicotine Tob Res · April 2009 Featured Publication INTRODUCTION: Initial research on older smokers suggests that a subgroup of smokers with higher levels of psychological distress and health problems may be more likely to quit smoking than older smokers with fewer such problems. The present study, based on ... Full text Link to item Cite

The epidemiology of substance use and disorders among middle aged and elderly community adults: national survey on drug use and health.

Journal Article Am J Geriatr Psychiatry · March 2009 Featured Publication OBJECTIVE: To estimate the prevalence, distribution, and correlates of drug use among middle aged and elderly persons in the United States and to compare with alcohol use in this age group. SETTING: The 2005 and 2006 National Surveys on Drug Use and Health ... Full text Open Access Link to item Cite

Treating Late-Life Depression: Aiming for the Optimum

Conference AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · March 1, 2009 Link to item Cite

Depressive symptoms moderate the influence of the apolipoproteine epsilon4 allele on cognitive decline in a sample of community dwelling older adults.

Journal Article Am J Geriatr Psychiatry · February 2009 Featured Publication OBJECTIVES: The apolipoproteinE epsilon4 (APOE epsilon4) allele and a history of depression are each separate risk factors for cognitive decline (CD). However, little research has investigated whether a history of depression influences the relationship bet ... Full text Link to item Cite

The variety of ecstasy/MDMA users: results from the National Epidemiologic Survey on alcohol and related conditions.

Journal Article Am J Addict · 2009 Featured Publication This study investigates the potential heterogeneity of ecstasy or MDMA (3,4-methylenedioxy-N-methylamphetamine) users. Data came from the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Latent class analysis (LCA) and mu ... Full text Open Access Link to item Cite

Heterogeneity of stimulant dependence: a national drug abuse treatment clinical trials network study.

Journal Article Am J Addict · 2009 Featured Publication We investigated the presence of DSM-IV subtyping for dependence on cocaine and amphetamines (with versus without physical dependence) among outpatient stimulant users enrolled in a multisite study of the Clinical Trials Network (CTN). Three mutually exclus ... Full text Open Access Link to item Cite

Racial differences in the influence of the APOE epsilon 4 allele on cognitive decline in a sample of community-dwelling older adults.

Journal Article Gerontology · 2009 Featured Publication BACKGROUND: Most, but not all, past studies have suggested that the APOE genotype is a risk factor for dementia in whites but not African Americans. This paper first describes explanations as to why some studies may have failed to detect the effect of APOE ... Full text Link to item Cite

Pathologic response to preoperative chemotherapy: a new outcome end point after resection of hepatic colorectal metastases.

Journal Article J Clin Oncol · November 20, 2008 PURPOSE: The primary goal of this study was to evaluate whether pathologic response to chemotherapy predicts patient survival after preoperative chemotherapy and resection of colorectal liver metastases (CLM). The secondary goal of the study was to identif ... Full text Link to item Cite

Social support in older individuals: the role of the BDNF Val66Met polymorphism.

Journal Article Am J Med Genet B Neuropsychiatr Genet · October 5, 2008 Although often viewed as a purely environmental construct, perception of social support may be influenced by genetic factors. This study examined the relationship between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and social support ... Full text Link to item Cite

Cerebrospinal fluid dehydroepiandrosterone levels are correlated with brain dehydroepiandrosterone levels, elevated in Alzheimer's disease, and related to neuropathological disease stage.

Journal Article J Clin Endocrinol Metab · August 2008 OBJECTIVE: It is currently unknown whether cerebrospinal fluid (CSF) neurosteroid levels are related to brain neurosteroid levels in humans. CSF and brain dehydroepiandrosterone (DHEA) levels are elevated in patients with Alzheimer's disease (AD), but it i ... Full text Link to item Cite

How do you feel about...? Health outcomes in late life and self-perceptions of health and well-being.

Journal Article Gerontologist · August 2008 Research has shown over the years that the self-perceptions of older adults about their health and well-being may be at least as important as objective data for predicting the course of their health over time. I review a series of studies that span 30 year ... Full text Link to item Cite

Strategies for resection using portal vein embolization: hepatocellular carcinoma and hilar cholangiocarcinoma.

Journal Article Semin Intervent Radiol · June 2008 Preoperative portal vein embolization (PVE) is increasingly used to optimize the volume and function of the future liver remnant (FLR) and to reduce the risk for complications of major hepatectomy for hepatocellular carcinoma (HCC) or hilar cholangiocarcin ... Full text Link to item Cite

The course of depressive symptoms in older adults with comorbid major depression and dysthymia.

Journal Article Am J Geriatr Psychiatry · April 2008 OBJECTIVE: To examine the course of depressive symptoms in older patients with comorbid major depression and dysthymia. DESIGN: Secondary data analysis using both proportional hazards modeling and a repeated measures mixed model. SETTING: Clinical Research ... Full text Link to item Cite

ACNP White Paper: update on use of antipsychotic drugs in elderly persons with dementia.

Journal Article Neuropsychopharmacology · April 2008 In elderly persons, antipsychotic drugs are clinically prescribed off-label for a number of disorders outside of their Food and Drug Administration (FDA)-approved indications (schizophrenia and bipolar disorder). The largest number of antipsychotic prescri ... Full text Link to item Cite

The influence of lifetime depression on self-reported memory and cognitive problems: results from the National Comorbidity Survey-Replication.

Journal Article Aging Ment Health · March 2008 The current study investigated the association between lifetime major depressive disorder (MDD) and self-reported memory and cognitive problems in a general population sample. The study was based on data from the National Comorbidity Survey-Replication (n ... Full text Link to item Cite

Profiles of Functional Impairment in Older Patients Treated for Major Depression

Conference AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · March 1, 2008 Link to item Cite

Social Support in Older Individuals: The Role of the BDNF Va166Met Polymorphism

Conference AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · March 1, 2008 Link to item Cite

Depression in long-term care.

Journal Article J Am Med Dir Assoc · February 2008 OBJECTIVES: To review the diagnosis and treatment of depressive disorders in long-term care settings. METHODS: A review of the literature on the diagnosis and treatment of depression in long-term care. RESULTS: Up to 35% of residents in long-term care faci ... Full text Link to item Cite

Distal pancreatectomy for isolated metastasis of endometrial carcinoma to the pancreas.

Journal Article JOP · January 8, 2008 CONTEXT: The majority of oncological pancreatic resections involve resection of primary pancreatic tumors. Pancreatic resection for metastatic disease is rare but can produce durable palliation or even cure in carefully selected patients. Herein, we report ... Link to item Cite

Epidemiology of psychiatric illness

Journal Article · January 1, 2008 The science of epidemiology has much to offer in assisting clinical investigators and practicing psychiatrists to place the work on inpatient units and outpatient clinics into context. Epidemiologists first emphasize the importance of case identification a ... Full text Cite

Infrequent illicit methadone use among stimulant-using patients in methadone maintenance treatment programs: a national drug abuse treatment clinical trials network study.

Journal Article Am J Addict · 2008 We sought to determine the prevalence, patterns, and correlates of past-month illicit methadone use and history of regular illicit use among stimulant-using methadone maintenance treatment patients. We obtained self-reported information on illicit methadon ... Full text Open Access Link to item Cite

Religious and spiritual factors and the consequences of trauma: a review and model of the interrelationship.

Journal Article Int J Psychiatry Med · 2008 OBJECTIVE: An increasing body of literature examines the association of religious factors with posttraumatic stress as well as posttraumatic growth. This review of selected empirical studies describes religious and spiritual factors that have been examined ... Full text Link to item Cite

Geographical segregation and IL-6: a marker of chronic inflammation in older adults.

Journal Article Biomark Med · 2008 AIM: To examine environmental sociodemographic risks of high IL-6, a marker of chronic inflammation in older adults. METHODS: We spatially linked 1990 USA Census tract demographic and economic measures to a prospective cohort study of representative commun ... Full text Link to item Cite

Application of assessing care of vulnerable elders-3 quality indicators to patients with advanced dementia and poor prognosis.

Journal Article J Am Geriatr Soc · October 2007 OBJECTIVES: To use a formal decision-making strategy to reach clinically appropriate, internally consistent decisions on the application of quality indicators (QIs) to vulnerable elders (VEs) with advanced dementia (AD) or poor prognosis (PP). DESIGN: Usin ... Full text Link to item Cite

Body mass index and depressive symptoms in older adults: the moderating roles of race, sex, and socioeconomic status.

Journal Article Am J Geriatr Psychiatry · September 2007 OBJECTIVE: Although the long-term health risks associated with obesity in older adults have been well documented, less is known about the psychological consequences. The current study examined the relationship between body mass index (BMI) and subsequent d ... Full text Link to item Cite

Traumatic events and posttraumatic stress in cross-cultural mission assignments.

Journal Article J Trauma Stress · August 2007 In addition to cross-cultural and environmental stressors, aid workers and missionaries are frequently exposed to trauma. We explored the frequency of traumatic events, their mental health impact, and factors associated with posttraumatic stress in two gro ... Full text Link to item Cite

The relationship between spirituality and depressive symptoms: testing psychosocial mechanisms.

Journal Article J Nerv Ment Dis · August 2007 Although many studies suggest lower rates of depressive symptoms in those who report greater spirituality, few have investigated the mechanisms by which spirituality might relate to depressive symptoms. The current study aimed to elucidate potential psycho ... Full text Link to item Cite

Inguinal node dissection for melanoma in the era of sentinel lymph node biopsy.

Journal Article Surgery · June 2007 BACKGROUND: With the introduction of sentinel lymph node (SLN) biopsy for melanoma, inguinal lymph node dissections (ILND) are more commonly performed for microscopic disease than for clinically palpable disease. We sought to examine the effect this change ... Full text Link to item Cite

Surgical therapy of cutaneous melanoma.

Journal Article Semin Oncol · June 2007 For most solid tumors therapy has evolved from surgery alone to a multidisciplinary approach. Malignant melanoma remains an exception, with surgery maintaining the principal role not only for treatment of the primary lesion but also staging and the managem ... Full text Link to item Cite

Depressive symptoms and indicators of maternal health status during pregnancy.

Journal Article J Womens Health (Larchmt) · May 2007 OBJECTIVES: Depressive symptoms are common among women, especially those who are of childbearing age or are pregnant. Prior studies have suggested that an increased burden of depressive symptoms is associated with diminished health and functional status, b ... Full text Link to item Cite

Health service use and outcome: comparison of low charge, integrated, comprehensive services with usual health care.

Journal Article Aging Ment Health · March 2007 We examined the effects of use of low charge, integrated and comprehensive health care services (Veterans Administration (VA) health care system) on health care service use and health-related outcomes. Data came from the 10-year (1986/87-1996/97) Duke Esta ... Full text Link to item Cite

Perception of unmet basic needs as a predictor of depressive symptoms among community-dwelling older adults.

Journal Article J Gerontol A Biol Sci Med Sci · February 2007 BACKGROUND: In previous studies we found that, among older adults (>64 years), perception that basic needs were not being met increased mortality risk and risk for functional decline. In this study, we determined, controlling for reported income and functi ... Full text Link to item Cite

Millennium Cohort: the 2001-2003 baseline prevalence of mental disorders in the U.S. military.

Journal Article J Clin Epidemiol · February 2007 OBJECTIVES: The 12-month prevalence of common mental illnesses in the United States is estimated to be 26%, accounting for an increasing fraction of all disability in the general population. The U.S. military is a unique group involved in response and defe ... Full text Link to item Cite

The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases.

Journal Article Eur J Epidemiol · 2007 Many long-term prospective studies have reported on associations of cardiovascular diseases with circulating lipid markers and/or inflammatory markers. Studies have not, however, generally been designed to provide reliable estimates under different circums ... Full text Link to item Cite

Anxiety Disorders

Chapter · January 1, 2007 Full text Cite

Maternal prenatal pregnancy-related anxiety and spontaneous preterm birth in Baltimore, Maryland.

Journal Article Psychosom Med · 2007 OBJECTIVE: To focus on the relationship between pregnancy-related anxiety and spontaneous preterm birth. Psychosocial factors have been the subject of inquiries about the etiology of preterm birth; a factor of recent interest is maternal prenatal pregnancy ... Full text Link to item Cite

Effect of cancer screening and desirable health behaviors on functional status, self-rated health, health service use and mortality.

Journal Article J Am Geriatr Soc · January 2007 OBJECTIVES: To determine whether some health behaviors of older people (e.g., obtaining cancer screens) have a limited and others (e.g., exercise) have a broad association with population-level health status 4 to 6 years later. DESIGN: Longitudinal cohort. ... Full text Link to item Cite

Response letter to Dr. Cheng [2]

Journal Article Journal of the American Geriatrics Society · January 1, 2007 Full text Cite

Anxiety disorders

Journal Article · January 1, 2007 Full text Cite

The neurosteroid allopregnanolone is reduced in prefrontal cortex in Alzheimer's disease.

Journal Article Biol Psychiatry · December 15, 2006 BACKGROUND: Few data are currently available investigating neurosteroids (NS) in Alzheimer's disease (AD). The NS allopregnanolone may be decreased in serum and plasma in patients with AD, but it is unclear if allopregnanolone is also reduced in brain. Bec ... Full text Link to item Cite

Genes, behavior, and the social environment: Moving beyond the nature/nurture debate

Book · December 7, 2006 Over the past century, we have made great strides in reducing rates of disease and enhancing people's general health. Public health measures such as sanitation, improved hygiene, and vaccines; reduced hazards in the workplace; new drugs and clinical proced ... Full text Cite

Spirituality and depressive symptoms in a racially diverse US sample of community-dwelling adults.

Journal Article J Nerv Ment Dis · December 2006 The role of spirituality in depression is understudied. We examined the relationship between one dimension of spirituality, spiritual experiences, and depressive symptoms, and evaluated whether differences in gender, race, age, and stress moderated the rel ... Full text Link to item Cite

Perception of unmet basic needs as a predictor of physical functioning among community-dwelling older adults.

Journal Article J Aging Health · December 2006 OBJECTIVES: The present study examined the influence of participant's perception that their basic needs were not being met on their physical functioning problems. The association between lower social economic status (SES), typically indexed by income and e ... Full text Link to item Cite

Spirituality, depression, and the elderly.

Journal Article South Med J · October 2006 Full text Link to item Cite

Leighton's theory of sentiments: explorations and speculations on barriers to interpersonal forgiveness.

Journal Article Transcult Psychiatry · September 2006 In My Name Is Legion (Leighton, 1959), the basic assumption of Alexander H. Leighton's theory of sentiment is as follows: 'A given personality exists more or less continuously throughout life in the act of striving, and interference with that striving has ... Full text Link to item Cite

Provider characteristics related to antidepressant use in older people.

Journal Article J Am Geriatr Soc · June 2006 OBJECTIVES: To determine whether the characteristics of the usual medical care providers of older antidepressant users changed between 1986 and 1997 with the introduction of selective serotonin reuptake inhibitors. DESIGN: Longitudinal study. SETTING: Five ... Full text Link to item Cite

Sociodemographic characteristics of the neighborhood and depressive symptoms in older adults: using multilevel modeling in geriatric psychiatry.

Journal Article Am J Geriatr Psychiatry · June 2006 OBJECTIVE: Neighborhood sociodemographic characteristics may be important to the mental health of older adults who have decreased mobility and fewer resources. Our objective was to examine the association between neighborhood context and level of depressiv ... Full text Link to item Cite

Racial disparities in elevated prenatal depressive symptoms among black and white women in eastern north Carolina.

Journal Article Ann Epidemiol · June 2006 PURPOSE: Black women have an increased risk for preterm birth compared with white women, and prior research indicated that maternal prenatal depressive symptoms are associated with increased risk for preterm outcomes among black women. Race-related differe ... Full text Link to item Cite

Partial remission. A common outcome in older adults treated for major depression.

Journal Article Geriatrics · April 2006 Major depression can affect up to 10% of older adults in clinical samples. Longitudinal studies of older adults with major depression report that a significant proportion of patients do not fully recover. Partial remission or symptoms of major depression t ... Link to item Cite

Metabolic syndrome predicts mobility decline in a community-based sample of older adults.

Journal Article J Am Geriatr Soc · March 2006 OBJECTIVES: To determine whether metabolic syndrome is an independent predictor of decline in mobility in an elderly community sample. DESIGN: Biracial community-based prospective cohort study. SETTING: Urban and rural areas of central North Carolina. PART ... Full text Link to item Cite

Foreword

Chapter · 2006 Cite

Successful aging.

Journal Article Am J Geriatr Psychiatry · January 2006 Full text Link to item Cite

Children of Alzheimer patients: an overview.

Journal Article J Geriatr Psychiatry Neurol · December 2005 Full text Link to item Cite

Racial differences in cognitive decline in a sample of community-dwelling older adults: the mediating role of education and literacy.

Journal Article Am J Geriatr Psychiatry · November 2005 OBJECTIVE: The authors examined racial differences in cognitive decline (CD) and the role of education and literacy in mediating this relationship. METHODS: The relationship between race and CD was examined over a 3-year period in a biracial community samp ... Full text Link to item Cite

Origins of depression in later life.

Journal Article Psychol Med · September 2005 BACKGROUND: Despite the burden of depression in late life, its origins present a paradox to investigators and clinicians alike. METHOD: We review biological (genetics and heredity factors, neurotransmitter dysfunction, endocrine changes, vascular disorders ... Full text Link to item Cite

Aging-related diagnostic variations: need for diagnostic criteria appropriate for elderly psychiatric patients.

Journal Article Biol Psychiatry · August 15, 2005 It is commonly thought and taught that most psychiatric disorders other than dementia are much less prevalent among the elderly than among younger adults. This perception is based on a relatively small number of published epidemiologic investigations of th ... Full text Link to item Cite

Predictors of partial remission in older patients treated for major depression: the role of comorbid dysthymia.

Journal Article Am J Geriatr Psychiatry · August 2005 OBJECTIVE: The authors studied demographic, clinical, social, and perceived health and well-being factors as predictors of partial remission in older patients treated for major depressive disorder (MDD). METHODS: The sample included 186 patients who met DS ... Full text Link to item Cite

The influence of depression on cognitive decline in community-dwelling elderly persons.

Journal Article Am J Geriatr Psychiatry · May 2005 OBJECTIVE: An association between depression and cognitive decline (CD) has been observed in cross-sectional and case/control studies of elderly populations. Whereas a handful of longitudinal community studies have found depressive symptoms to predate the ... Full text Link to item Cite

Racial differences in the frequency of depressive symptoms among community dwelling elders: the role of socioeconomic factors.

Journal Article Aging Ment Health · May 2005 In a biracial sample of community dwelling elders (n=4162, the Duke EPESE), African-Americans endorsed more items than Whites on a standardized depression scale, the CES-D, in unadjusted, cross-sectional analyses. However, indices of socioeconomic status ( ... Full text Link to item Cite

Predictors of antidepressant use among older adults: have they changed over time?

Journal Article Am J Psychiatry · April 2005 OBJECTIVE: Antidepressant use increased substantially among older adults with the introduction of the new-generation medications such as the selective serotonin reuptake inhibitors. The authors analyzed data from two follow-up intervals-1986-1987 to 1989-1 ... Full text Link to item Cite

Perception of unmet basic needs as a predictor of mortality among community-dwelling older adults.

Journal Article Am J Public Health · February 2005 OBJECTIVES: We sought to determine whether, among older adults (>65 years), a perception that their basic needs are not being met increased mortality risk and whether this risk varied by race/ethnicity. METHODS: We used Cox proportional hazards modeling to ... Full text Link to item Cite

Childhood sexual and physical abuse and the 1-year prevalence of medical problems in the National Comorbidity Survey.

Journal Article Health Psychol · January 2005 In a population sample (N=5,877; ages 15 to 54), the authors found childhood sexual and physical abuse to be associated with the 1-year prevalence of serious health problems for both men and women. The authors also found that participants' psychiatric diso ... Full text Link to item Cite

Self-reported delay in seeking care has poor validity for predicting adverse outcomes.

Journal Article J Am Geriatr Soc · December 2004 OBJECTIVES: To determine whether self-reports of delayed care predict increased mortality and functional decline in community-dwelling elderly. DESIGN: Longitudinal cohort study. SETTING: Five counties in North Carolina. PARTICIPANTS: A total of 4,162 rand ... Full text Link to item Cite

What symptoms of depression predict mortality in community-dwelling elders?

Journal Article J Am Geriatr Soc · December 2004 OBJECTIVES: To determine which symptoms of depression are most likely to increase the risk of mortality in a biracial sample of older adults. DESIGN: Cross-sectional and longitudinal study. SETTING: Baseline and mortality follow-up in urban and rural North ... Full text Link to item Cite

Is the APOE ε4 allele a risk to person-environment fit?

Journal Article Journal of Applied Gerontology · September 1, 2004 This study uses Lawton's model of "the good life " to examine whether the Apolipoprotein E-ε4 genotype functions as a risk factor not only for specific diseases but also for a misfit between elders' personal needs and their physical and social environments ... Full text Cite

In memoriam - Ewald W. Busse, MD, ScD, 1918-2004

Journal Article AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · September 1, 2004 Link to item Cite

Antiangiogenic gene therapy of cancer: recent developments.

Journal Article J Transl Med · June 25, 2004 With the role of angiogenesis in tumor growth and progression firmly established, considerable effort has been directed to antiangiogenic therapy as a new modality to treat human cancers. Antiangiogenic agents have recently received much widespread attenti ... Full text Link to item Cite

How the question is asked makes a difference in the assessment of depressive symptoms in older persons.

Journal Article Am J Geriatr Psychiatry · 2004 OBJECTIVE: The authors examined whether older adults respond comparably to two standard depression instruments rating symptoms by frequency/duration or degree of severity/"bother." METHODS: Data for this cross sectional analysis of a prospective cohort cam ... Link to item Cite

Epidemiology of late-life mental disorders.

Journal Article Clin Geriatr Med · November 2003 This article reviews the prevalence and incidence of mental disorders in older adults. The authors outline the epidemiologic challenges in determining the frequency of mental disorders in late-life and discuss issues that are critical for understanding the ... Full text Link to item Cite

Is there a role for sentinel lymph node biopsy in the management of sarcoma?

Journal Article Surg Oncol · November 2003 Is there a role for sentinel lymph node (SLN) biopsy in the management of sarcoma? Sentinel node biopsy has dramatically changed the management of melanoma and breast cancer, helping surgeons avoid radical lymphadenectomies in node negative patients who wo ... Full text Link to item Cite

APOE epsilon4 as a predictor of subjective quality of life in a biracial older person community sample.

Journal Article J Aging Health · November 2003 UNLABELLED: The epsilon4 allele of apolipoprotein E (APOE) has been associated with health-related outcomes that may adversely affect quality of life (QOL) in older adults. In the absence of published information, we sought to determine whether the epsilon ... Full text Link to item Cite

Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late life.

Journal Article Arch Gen Psychiatry · July 2003 OBJECTIVES: To review progress made during the past decade in late-life mood disorders and to identify areas of unmet need in health care delivery and research. PARTICIPANTS: The Consensus Development Panel consisted of experts in late-life mood disorders, ... Full text Link to item Cite

Appropriateness of quality indicators for older patients with advanced dementia and poor prognosis.

Journal Article J Am Geriatr Soc · July 2003 OBJECTIVES: To evaluate the applicability of process-of-care quality indicators (QIs) to vulnerable elders and to measure the effect of excluding indicators based on patients' preferences and for advanced dementia and poor prognosis. DESIGN: The Assessing ... Full text Link to item Cite

Mortality and apolipoprotein E in African-American, and White elders: an attempted replication.

Journal Article Am J Med Genet A · June 1, 2003 We have tried, with only partial success, to confirm findings in a recently reported study in this journal on the relationship of APOE genotype to mortality in community representative Hispanics (n = 659), Whites (n = 272), and African-Americans (n = 450), ... Full text Link to item Cite

Assessing depression in older persons: How you ask makes a difference.

Conference JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · April 1, 2003 Link to item Cite

Depression in late life: review and commentary.

Journal Article J Gerontol A Biol Sci Med Sci · March 2003 Depression is perhaps the most frequent cause of emotional suffering in later life and significantly decreases quality of life in older adults. In recent years, the literature on late-life depression has exploded. Many gaps in our understanding of the outc ... Full text Link to item Cite

Is the APOE epsilon4 genotype associated with higher hospital costs among elderly patients?

Journal Article Am J Geriatr Psychiatry · 2003 OBJECTIVE: The apolipoprotein epsilon4 (APOE epsilon4) genotype is associated with a number of adverse health outcomes. The authors assessed whether the epsilon4 genotype was associated with higher hospital costs on the basis of data from 1,999 white or bl ... Link to item Cite

Self-efficacy and depression in late life: a primary prevention proposal.

Journal Article Aging Ment Health · November 2002 Featured Publication Feelings of sadness and loneliness are ubiquitous in late life and a risk factor for depression and perhaps other mental illnesses in late life. Targeting sadness and loneliness for an intervention addresses both primary risk reduction for depressive disor ... Full text Link to item Cite

Depression in diabetes and obesity: racial/ethnic/gender issues in older adults.

Journal Article J Psychosom Res · October 2002 Featured Publication OBJECTIVES: This study focuses on the comorbidity between depression and diabetes, as well as depression and obesity, in a biracial community sample of older adults. METHODS: The data are drawn from a cross-sectional survey of five counties in North Caroli ... Full text Link to item Cite

Apolipoprotein E epsilon4 and risk of mortality in African American and white older community residents.

Journal Article Gerontologist · June 2002 Featured Publication PURPOSE: The goal of this study was to determine whether the epsilon4 allele of apolipoprotein E is predictive of mortality in a community-based sample. DESIGN AND METHODS: Of the stratified random household sample of 4,162 participants age 65 years and ol ... Full text Link to item Cite

The millennium Cohort Study: a 21-year prospective cohort study of 140,000 military personnel.

Journal Article Mil Med · June 2002 Does military service, in particular operational deployment, result in a higher risk of chronic illness among military personnel and veterans? The Millennium Cohort Study, the largest Department of Defense prospective cohort study ever conducted, will atte ... Link to item Cite

The prevalence of depressive symptoms.

Journal Article J Gerontol A Biol Sci Med Sci · March 2002 Full text Link to item Cite

Relationship of race/ethnicity and blood pressure to change in cognitive function.

Journal Article J Am Geriatr Soc · March 2002 Featured Publication OBJECTIVES: To determine whether there are racial/ethnic differences regarding the relationship of level of blood pressure to change in cognitive function in older people. DESIGN: Longitudinal data 1986 to 1989 on representative, older, community-residing ... Full text Link to item Cite

Abstinence versus alcohol use among elderly rural Baptists: a test of reference group theory and health outcomes.

Journal Article Aging Ment Health · February 2002 Featured Publication Reference groups, such as religious groups, are thought to provide individuals with normative frameworks which set and maintain standards for them. Persons who belong to a reference group, yet do not comply with the standards of that group, i.e. non-confor ... Full text Link to item Cite

The association of depression and mortality in elderly persons.

Journal Article J Gerontol A Biol Sci Med Sci · February 2002 Full text Link to item Cite

Sex differences in the relationship between subthreshold depression and mortality in a community sample of older adults.

Journal Article Am J Geriatr Psychiatry · 2002 Featured Publication The authors investigated the increased risk of mortality from subthreshold depression and examined differences in risk by gender. Data from the Duke University Established Populations for Epidemiologic Studies of the Elderly (EPESE) longitudinal study of 4 ... Link to item Cite

The impact of borderline personality disorder on post-traumatic stress in the community: a study of health status, health utilization, and functioning.

Journal Article Compr Psychiatry · 2002 Featured Publication This study examines impairment and health status and resource utilization among individuals with and without borderline personality disorder (BPD), all of whom had post-traumatic stress symptoms (PTSS). Using data from the community-based Piedmont Health S ... Full text Link to item Cite

APOE epsilon4 and low cholesterol as risks for depression in a biracial elderly community sample.

Journal Article Am J Geriatr Psychiatry · 2002 Featured Publication OBJECTIVE: The epsilon4 allele of apolipoprotein (APOE) is known to be associated with a number of adverse health outcomes, yet the association of the allele with depression has not been conclusively determined. The authors explored the hypothesis that the ... Link to item Cite

The APOE-E4 allele and the risk of functional decline in a community sample of African American and white older adults.

Journal Article J Gerontol A Biol Sci Med Sci · December 2001 Featured Publication BACKGROUND: Given previous findings of adverse health outcomes associated with the E4 allele, data from a biracial community sample of older adults were used to determine whether functional decline is associated with the apolipoprotein E (APOE) E4 allele. ... Full text Link to item Cite

Emotion: The science of sentiment

Journal Article JOURNAL OF PSYCHOSOMATIC RESEARCH · December 1, 2001 Link to item Cite

Breaking the watch: The meanings of retirement in America

Journal Article GERONTOLOGIST · October 1, 2001 Link to item Cite

The American Psychiatric Press Textbook of Psychopharmacology (Second Edition)

Journal Article Journal of Psychosomatic Research · October 2001 Full text Cite

Social integration in the second half of life

Journal Article GERONTOLOGIST · October 1, 2001 Link to item Cite

The relationship of APOE genotype to cognitive functioning in older African-American and Caucasian community residents.

Journal Article J Am Geriatr Soc · September 2001 Featured Publication OBJECTIVES: To determine whether cognitive decline associated with the apolipoprotein E (APOE) epsilon4 allele is different in older African Americans than it is in Caucasians. DESIGN: Performance on a brief screen of cognitive functioning was examined at ... Full text Link to item Cite

Handbook of the Sociology of Mental Health

Journal Article Archives of General Psychiatry · September 1, 2001 Full text Cite

The association of depression and mortality in elderly persons: a case for multiple, independent pathways.

Journal Article J Gerontol A Biol Sci Med Sci · August 2001 Featured Publication BACKGROUND: The evidence for an association between depression and mortality among community-dwelling elderly persons remains inconclusive, although it is well established for younger individuals. Extant studies suggest that this association weakens when a ... Full text Link to item Cite

Accuracy of self-reported stroke among elderly veterans.

Journal Article Aging Ment Health · August 2001 Featured Publication The objective was to use secondary analysis of prevalence data from a prospective cohort study to ascertain the accuracy of self-reported stroke among veterans. The study comprised a community-dwelling population of 88 elderly veterans (from five counties ... Full text Link to item Cite

Toward a threshold for subthreshold depression: an analysis of correlates of depression by severity of symptoms using data from an elderly community sample.

Journal Article Gerontologist · June 2001 PURPOSE: The prevalence of depressive symptoms in elderly adults is high, yet the criteria to identify clinically significant depression may leave many elders undiagnosed and untreated. We explored the demographic and risk factor profiles of two groups, on ... Full text Link to item Cite

Antidepressant use by race.

Journal Article Am J Psychiatry · June 2001 Full text Link to item Cite

Blood pressure and mortality risk in older people: comparison between African Americans and whites.

Journal Article J Am Geriatr Soc · April 2001 Featured Publication OBJECTIVES: To determine the risk from hypertension for all-cause mortality in a racially mixed sample of community-dwelling older adults. DESIGN: Baseline blood pressure was assessed between 1985 and 1986 in a sample of persons 65 years of age and older f ... Full text Link to item Cite

Duke's 3rd year: a 35-year retrospective.

Journal Article Teach Learn Med · 2001 PURPOSE: Our purpose was to review and evaluate Duke University School of Medicine's 3rd year. SUMMARY: Duke University School of Medicine instituted a dramatic change in its curriculum 35 years ago by restructuring the 1st, 2nd, and 4th years of medical s ... Full text Link to item Cite

Psychiatry and the oldest old.

Journal Article Am J Psychiatry · December 2000 OBJECTIVE: This article reviews the assessment and management of psychiatric problems among the oldest old. METHOD: The author reviewed the English-language literature pertinent to the characteristics of people 85 years old or older and the assessment and ... Full text Link to item Cite

A multivariate analysis of factors associated with depression: evaluating the role of health literacy as a potential contributor.

Journal Article Arch Intern Med · November 27, 2000 BACKGROUND: High rates of low health literacy among elderly populations along with a high prevalence of chronic conditions may lead to increased levels of depression symptomatology. We sought to determine whether older adults with inadequate health literac ... Full text Link to item Cite

Impact of depressive symptoms on hospitalization risk in community-dwelling older persons.

Journal Article J Am Geriatr Soc · October 2000 OBJECTIVE: To determine whether depressive symptoms in older adults are associated with an increased risk for hospitalization. DESIGN: A 6 month cohort study. SETTING: Five counties in the northern Piedmont of North Carolina from the Duke University site o ... Full text Link to item Cite

Sedative, hypnotic, and antianxiety medication use in an aging cohort over ten years: a racial comparison.

Journal Article J Am Geriatr Soc · September 2000 OBJECTIVES: Prescriptions of sedatives, hypnotics, and antianxiety medications have decreased over the past 15 years. However, racial differences have not been well investigated in controlled analyses. DESIGN: A prospective cohort study. SETTINGS AND PARTI ... Full text Link to item Cite

Marked differences in antidepressant use by race in an elderly community sample: 1986-1996.

Journal Article Am J Psychiatry · July 2000 OBJECTIVE: Prescriptions of antidepressant medications have increased significantly over the past 15 years across the life cycle. One overall correlate of medication use in older adults is race, with African Americans using fewer medications than whites. G ... Full text Link to item Cite

Does private religious activity prolong survival? A six-year follow-up study of 3,851 older adults.

Journal Article J Gerontol A Biol Sci Med Sci · July 2000 BACKGROUND: Previous studies have linked higher religious attendance and longer survival. In this study, we examine the relationship between survival and private religious activity. METHODS: A probability sample of elderly community-dwelling adults in Nort ... Full text Link to item Cite

Social and personal resources and the prevalence of phobic disorder in a community population.

Journal Article Psychol Med · May 2000 BACKGROUND: Phobic disorder is one of the most prevalent psychiatric disorders in community populations and much attention has focused on the association of sociodemographic factors and social resources with the disorder. There has been little investigatio ... Full text Link to item Cite

The effect of race and health-related factors on naming and memory. The MacArthur Studies of Successful Aging.

Journal Article J Aging Health · February 2000 OBJECTIVES: The purpose of the analyses was to examine the impact of health-related variables on race differences in neuropsychological functioning (Boston Naming Task). METHODS: Using cross-sectional data from the MacArthur Successful Aging Study, the aut ... Full text Link to item Cite

Religious activity, alcohol use, and depression in a sample of elderly baptists

Journal Article Research on Aging · January 1, 2000 Recent research has shown the beneficial effects of religious activity for individual health and well-being among older adults. The purpose of this article is to determine whether breaking the norms of the religious group can have deleterious consequences ... Full text Cite

Vitamin D receptor polymorphisms and prostate cancer.

Journal Article Mol Carcinog · January 2000 Prostate cancer is a common disease, yet determinants of prostate cancer risk remain largely unidentified. Low circulating levels of 1, 25-dihydroxy vitamin D (1,25-D) have been implicated as a risk factor for prostate cancer. In addition, 1,25-D exhibits ... Full text Link to item Cite

Issues for academic health centers to consider before implementing a balanced-scorecard effort.

Journal Article Acad Med · December 1999 Because of changes in the health care environment, it is likely that strategic planning and management will become much more important to academic health centers (AHCs) than in the past. One approach to strategic planning and management that is gaining the ... Full text Link to item Cite

New onset and remission of suicidal ideation among a depressed adult sample.

Journal Article J Affect Disord · November 1999 BACKGROUND: Previous research has demonstrated that suicidal ideation often predicts suicide completion. METHODS: The present study examined clinical and phenomenological variables associated with the presence, development and remission of suicidal ideatio ... Full text Link to item Cite

Correlates of suicidal ideation among an elderly depressed sample.

Journal Article J Affect Disord · November 1999 BACKGROUND: Suicidal ideation has been shown to be strongly associated with suicide completion and elders take their own lives more than any other age group. METHODS: The present study examined clinical and phenomenological correlates of suicidal ideation ... Full text Link to item Cite

Insomnia and heart disease: a review of epidemiologic studies.

Journal Article J Psychosom Res · October 1999 Since the discovery and successful treatment of sleep apnea, researchers seem to believe that the association between sleep disturbance and coronary heart disease (CHD) has been explained. To determine whether subjective nighttime sleep complaints (trouble ... Full text Link to item Cite

Functional impairment and utilization of services associated with posttraumatic stress in the community.

Journal Article J Trauma Stress · October 1999 This study describes social functioning and service utilization patterns associated with posttraumatic stress symptoms relative to nonpsychiatric controls and depressive disorder controls in a cross-sectional epidemiological survey. Data from 49 cases and ... Full text Link to item Cite

Perceived social support among depressed elderly, middle-aged, and young-adult samples: cross-sectional and longitudinal analyses.

Journal Article J Affect Disord · October 1999 BACKGROUND: A number of studies have concluded that the perceived quality of support is more strongly associated with mental health than with the actual structure of personal networks. This study examined clinical, historical, and phenomenological variable ... Full text Link to item Cite

Depression and the older man.

Journal Article Med Clin North Am · September 1999 Older women report more depressive symptoms in community samples and are also more likely to seek medical care, although the frequency of suicide is more common among older men. Depression in the older man has been neglected by both investigators and clini ... Full text Link to item Cite

Does religious attendance prolong survival? A six-year follow-up study of 3,968 older adults.

Journal Article J Gerontol A Biol Sci Med Sci · July 1999 METHODS: A probability sample of 3,968 community-dwelling adults aged 64-101 years residing in the Piedmont of North Carolina was surveyed in 1986 as part of the Established Populations for the Epidemiologic Studies of the Elderly (EPESE) program of the Na ... Full text Link to item Cite

Incidence and remission of insomnia among elderly adults: an epidemiologic study of 6,800 persons over three years.

Journal Article Sleep · May 1, 1999 To determine incidence and remission rates of insomnia in older adults and associated risk factors. Three-year longitudinal study, 1982-198--East Boston, MA; New Haven, CT; Iowa and Washington counties, IA. Participants were 6,899 men and women aged 65 yea ... Link to item Cite

Incidence and remission of insomnia among elderly adults in a biracial cohort.

Journal Article Sleep · May 1, 1999 OBJECTIVES: To determine the incidence and remission rates of insomnia in older adults according to race and associated risk factors in a three-year longitudinal study. METHODS: 2,971 men and women, aged 65 years and older, completed questionnaires adminis ... Link to item Cite

EURODEP Consortium and late-life depression.

Journal Article Br J Psychiatry · April 1999 Full text Link to item Cite

Disability and depressive symptoms in the elderly: the effects of instrumental support and its subjective appraisal.

Journal Article Int J Aging Hum Dev · 1999 This article explores the buffering effect of social support on depressive symptoms in a community sample of elderly with varying levels of disability. Baseline interviews were conducted in respondents' homes. Results show that higher levels of disability ... Full text Link to item Cite

Association of interleukin-6 and other biologic variables with depression in older people living in the community.

Journal Article J Am Geriatr Soc · January 1999 OBJECTIVES: The prevalence of depression increases with age, as does the prevalence of higher levels of the cytokine interleukin-6 (IL-6). This analysis was performed to determine the association between increased levels of this cytokine and depression in ... Full text Link to item Cite

Dysthymia, somatisation disorder and generalised anxiety in the elderly

Conference LATE-ONSET MENTAL DISORDERS · January 1, 1999 Link to item Cite

Benzodiazepine use and cognitive function among community-dwelling elderly.

Journal Article Clin Pharmacol Ther · December 1998 OBJECTIVE: To evaluate the relation between benzodiazepine use and cognitive function among community-dwelling elderly. METHODS: This prospective cohort study included 2765 self-reporting subjects from the Duke Established Populations for Epidemiologic Stu ... Full text Link to item Cite

Symptoms of depression among community-dwelling elderly African-American and white older adults.

Journal Article Psychol Med · November 1998 BACKGROUND: Few studies have explored the variance in individual symptoms by race in older adults. METHODS: Data were analysed from the Duke site of the Established Populations for Epidemiologic Studies of the Elderly (EPESE), a community sample of persons ... Full text Link to item Cite

Aging, health, and the "electronic church".

Journal Article J Aging Health · November 1998 We tested whether elders substitute religious media use for church attendance when health declines (using multidimensional disengagement theory) with data from a multiracial, population-based sample in the Bible Belt (N = 2,971). In adjusted models, 3-year ... Full text Link to item Cite

The relationship between religious activities and cigarette smoking in older adults.

Journal Article J Gerontol A Biol Sci Med Sci · November 1998 BACKGROUND: The objective of this study was to examine the relationship between religious activities and cigarette smoking in community-dwelling older adults. METHODS: Cigarette smoking and religious activities were assessed in a probability sample of 3968 ... Full text Link to item Cite

Prevalence of seasonal affective disorder.

Journal Article Br J Psychiatry · September 1998 Full text Link to item Cite

Are sleep complaints an independent risk factor for myocardial infarction?

Journal Article Ann Epidemiol · August 1998 PURPOSE: To investigate whether subjective sleep complaints are an independent predictor of myocardial infarction (MI) in a community of older adults and to gain clues as to why the association between sleep complaints and incident MI exists. METHODS: Usin ... Full text Link to item Cite

Managing depression in the elderly

Journal Article Patient Care · May 15, 1998 Depression is prevalent in elderly patients but frequently missed or undertreated. A practical, systematic approach can help you improve quality of life for the depressed elderly and reduce disability, suicide rates, and unnecessary health care costs in th ... Cite

Epidemiology of recurrent major and minor depression with a seasonal pattern. The National Comorbidity Survey.

Journal Article Br J Psychiatry · February 1998 BACKGROUND: Previous estimates of the prevalence of seasonal affective disorder (SAD) in community samples have been in the range 2-10%, using methods not derived from DSM algorithms. We report the first community-based study to estimate major and minor de ... Full text Link to item Cite

Suicidal behaviors in depressed men with a family history of suicide: Effects of psychosocial factors and age

Journal Article Aging and Mental Health · January 1, 1998 Effects of impaired social support and stressful life events on non-lethal suicidal behaviors were examined in a clinical sample of high-risk patients: depressed adult men with a family history of suicide or attempted suicide. All subjects (N = 79) were pa ... Full text Cite

Social correlates of the dimensions of depression in the elderly.

Journal Article J Gerontol B Psychol Sci Soc Sci · January 1998 Few investigations of the social correlates of depressive symptomatology have addressed variation in the correlates across multiple dimensions of depression scales. We examined the relationships of selected social, clinical, and demographic correlates with ... Full text Link to item Cite

Age of first onset of bipolar disorder: demographic, family history, and psychosocial correlates.

Journal Article Depress Anxiety · 1998 The literature suggests that bipolar elders with early and late onset of the disorder present with different demographic, family history, and psychosocial profiles, which are less well characterized than those for elderly unipolar patients. In this cross-s ... Link to item Cite

The relationship between religious activities and blood pressure in older adults.

Journal Article Int J Psychiatry Med · 1998 OBJECTIVE: To examine the relationship between religious activities and blood pressure in community-dwelling older adults. METHOD: Blood pressure and religious activities were assessed in a probability sample of 3,963 persons age sixty-five years or older ... Full text Link to item Cite

Six-month outcomes for MRI-related vascular depression.

Journal Article Depress Anxiety · 1998 The purpose of this paper is to estimate the relative probabilities of 6-month recovery from an index episode of major depression for subjects with and without MRI-confirmed vascular brain changes. In this cohort study, 57 depressed subjects from the Duke ... Full text Link to item Cite

Late life affective disorders

Journal Article Archives of Gerontology and Geriatrics · January 1, 1998 Late life mood disorders are subject to many misconceptions. In this paper, misconceptions about the symptomatology, frequency and treatment of late life depression are reviewed. If late life depression is not complicated by comorbid physical illness or de ... Full text Cite

Psychosocial and physical correlates of chronic depression.

Journal Article Psychiatry Res · October 10, 1997 This study used a case-control design to address differences in psychosocial, physical and clinical profiles between subjects who presented with a chronic index episode of major depression and those who presented with a non-chronic index episode. Subjects ... Full text Link to item Cite

Prevalence, correlates, and course of minor depression and major depression in the National Comorbidity Survey.

Journal Article J Affect Disord · August 1997 Data from the National Comorbidity Survey are used to study the lifetime prevalences, correlates, course and impairments associated with minor depression (mD), major depression 5-6 symptoms (MD 5-6), and major depression with seven or more symptoms (MD 7-9 ... Full text Link to item Cite

Double depression: A distinctive subtype of unipolar depression - Discussion

Journal Article JOURNAL OF AFFECTIVE DISORDERS · August 1, 1997 Link to item Cite

Memory complaint as a predictor of cognitive decline: a comparison of African American and White elders.

Journal Article J Aging Health · May 1997 Of a representative, racially mixed community sample of older adults in North Carolina, 59% of Whites and 49% of African Americans reported worsening memory. The complaint about memory was positively correlated with age, depressive symptomatology, and phys ... Full text Link to item Cite

MRI-defined vascular depression.

Journal Article Am J Psychiatry · April 1997 OBJECTIVE: The authors' goal was to characterize the clinical and demographic features of vascular depression. METHOD: They classified 89 depressed patients into two groups-those with vascular (N = 32) and nonvascular (N = 57) depression-on the basis of ex ... Full text Link to item Cite

Depression in the elderly. Myths and misconceptions.

Journal Article Psychiatr Clin North Am · March 1997 Despite myths to the contrary, existing evidence suggests that depression in the elderly is not different in its symptoms, more frequent, more chronic, more difficult to treat, or more attributable to psychosocial factors than depression in younger persons ... Full text Link to item Cite

Social support and depression as risk factors for loss of physical function in late life

Journal Article Aging and Mental Health · January 1, 1997 Poor physical function status in elders is a robust predictor of not only medical service use and institutionalization but also mortality. We assessed whether depressive symptoms and low social support would predict deficits in three domains of physical fu ... Full text Cite

Medicine as a mission.

Journal Article N C Med J · 1997 Link to item Cite

Attendance at religious services, interleukin-6, and other biological parameters of immune function in older adults.

Journal Article Int J Psychiatry Med · 1997 OBJECTIVE: First, to examine and explain the relationship between religious service attendance and plasma Interleukin-6 (IL-6) levels, and second, to examine the relationship between religious attendance and other immune-system regulators and inflammatory ... Full text Link to item Cite

Active immunization with tumor cells transduced by a novel AAV plasmid-based gene delivery system.

Journal Article J Immunother · January 1997 Ex vivo genetically engineered cytokine-secreting tumor cell vaccines have been shown to prevent metastatic disease in animal models of lung and breast cancer. Because of the inefficiency of existing modes of gene delivery in transducing primary human tumo ... Full text Link to item Cite

Generalized anxiety disorder and panic disorder in the elderly: a review.

Journal Article Harv Rev Psychiatry · 1997 Practicing psychiatrists frequently encounter elderly patients with generalized anxiety disorder or panic disorder. Unfortunately, the empirical literature regarding the assessment, diagnosis, and treatment of these illnesses in older individuals is sparse ... Full text Link to item Cite

Inhibition of established pancreatic cancers following specific active immunotherapy with interleukin-2 gene-transduced tumor cells.

Journal Article Cancer Gene Ther · 1997 Pancreatic cancer has a poor prognosis even when complete resection can be accomplished. Recent studies have demonstrated that the immune system is capable of mounting effective tumor-specific immune responses even against "nonimmunogenic" tumors. The stud ... Link to item Cite

Modeling the cross-sectional relationships between religion, physical health, social support, and depressive symptoms.

Journal Article Am J Geriatr Psychiatry · 1997 The authors examined models of the relationships between religious activities, physical health, social support, and depressive symptoms in a sample of 4,000 persons age 65 and over. Religious activity was examined first as a single composite construct and ... Link to item Cite

Health indices as predictors of cognition among older African Americans: MacArthur studies of successful aging.

Journal Article Ethn Dis · 1997 Using cross-sectional and longitudinal data from the MacArthur Successful Aging Study, this paper examines associations between cognition and indices of health in 224 elderly African Americans 70 to 79 years of age at initial interview. The results indicat ... Link to item Cite

On the new clinical case conferences.

Journal Article Am J Psychiatry · January 1997 Full text Link to item Cite

Global self-ratings of health and mortality: hazard in the North Carolina Piedmont.

Journal Article J Clin Epidemiol · September 1996 We analyzed the first 5 years of surveillance data from the Established Population for the Epidemiologic Studies of the Elderly (EPESE) in the Piedmont of North Carolina (n = 4162) to estimate the effect of a global self-rating of health on survival. Covar ... Full text Link to item Cite

Minor depression in late life

Journal Article American Journal of Geriatric Psychiatry · September 1, 1996 Minor depression is a type of depressive disorder that does not fulfill the duration criteria or show the number of symptoms necessary to make the diagnosis of major depression. Defining minor depression, therefore, is difficult because of the many differe ... Cite

Minor depression in late life

Journal Article AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · September 1, 1996 Link to item Cite

Active immunotherapy of pancreatic cancer with tumor cells genetically engineered to secrete multiple cytokines.

Journal Article Surgery · August 1996 BACKGROUND: Vaccination of tumor-bearing animals with tumor cells genetically engineered to secrete cytokines including interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) has been shown to induce effective tumor-specific immune responses capable of inhi ... Full text Link to item Cite

Sociodemographic and clinical correlates of number of previous depressive episodes in the depressed elderly.

Journal Article J Affect Disord · July 8, 1996 Age of onset has been used as a correlate of depressive symptomatology in the elderly. Examining frequency of episodes may improve our ability to make such correlations. The authors studied variations in an index presentation of depression in late life bas ... Full text Link to item Cite

The association of sexual assault and attempted suicide within the community.

Journal Article Arch Gen Psychiatry · June 1996 BACKGROUND: Lifetime community rates of attempted suicide were compared between those who reported a history of sexual assault and a control group without such a history. METHODS: The 2918 respondents in the Duke University Epidemiological Catchment Area S ... Full text Link to item Cite

Risk of napping: excessive daytime sleepiness and mortality in an older community population.

Journal Article J Am Geriatr Soc · June 1996 OBJECTIVE: To describe the demographic and health-related factors related to excessive daytime sleepiness. To estimate the risk of mortality associated with excessive daytime sleepiness independent of nightime sleep problems and other factors that limit su ... Full text Link to item Cite

Effects of gender and ethnic group on blood pressure control in the elderly.

Journal Article Am J Hypertens · June 1996 In order to determine the adequacy of blood pressure treatment in black and white elderly men and women, the authors performed a cross-sectional population survey in Central North Carolina in 1986-1987. Participants included a random sample of noninstituti ... Full text Link to item Cite

Comorbidity of DSM-III-R major depressive disorder in the general population: results from the US National Comorbidity Survey.

Journal Article Br J Psychiatry Suppl · June 1996 General population data are presented on the prevalence and correlates of comorbidity between DSM-III-R major depressive disorder (MDD) and other DSM-III-R disorders. The data come from the US National Comorbidity Survey, a large general population survey ... Link to item Cite

Comorbidity of DSM-III-R major depressive disorder in the general population: results from the US National Comorbidity Survey.

Journal Article The British journal of psychiatry. Supplement · June 1, 1996 General population data are presented on the prevalence and correlates of comorbidity between DSM-III-R major depressive disorder (MDD) and other DSM-III-R disorders. The data come from the US National Comorbidity Survey, a large general population survey ... Cite

Do racial differences in hypertension persist in successful agers? Findings from the MacArthur Study of Successful Aging.

Journal Article J Aging Health · May 1996 The objective of this study was to determine whether racial differences in hypertension in a random sample of community-dwelling older adults also remained significant in a sample of successful agers. Data for the random sample of community-dwelling older ... Full text Link to item Cite

Is medication use by community-dwelling elderly people influenced by cognitive function?

Journal Article Age Ageing · May 1996 To determine whether medication use differs by cognitive status among community dwelling elderly, a survey was made of a stratified random sample of 4110 black and white participants, aged 65 or older from the Duke Established Populations for Epidemiologic ... Full text Link to item Cite

Factors associated with paranoid symptoms in a community sample of older adults.

Journal Article Gerontologist · February 1996 Symptoms of paranoia were found in 9.5% of a community sample of older adults in North Carolina. In cross-sectional analyses, these symptoms were associated most strongly with black race, lower income and education, less exercise, and more depressive sympt ... Full text Link to item Cite

Lifetime perturbations of bipolar disorder.

Journal Article Am J Psychiatry · January 1996 Full text Link to item Cite

Predictors of cognitive change in older persons: MacArthur studies of successful aging.

Journal Article Psychol Aging · December 1995 This study used a linear structural relations modeling technique (LISREL) to examine longitudinal data for 1,192 persons from a community-based population. The goal was to test the ability of an a priori model to predict cognitive change over a 2.0- to 2.5 ... Full text Link to item Cite

Interrelationships of peak expiratory flow rate with physical and cognitive function in the elderly: MacArthur Foundation studies of aging.

Journal Article J Gerontol A Biol Sci Med Sci · November 1995 BACKGROUND: Peak expiratory flow rate (PEFR) is correlated with several measures of health in the elderly, including physical and cognitive function. It is unclear, however, whether these relationships persist among the non-frail. METHODS: The Community-ba ... Full text Link to item Cite

Health services access and use among older adults in North Carolina: urban vs rural residents.

Journal Article Am J Public Health · October 1995 OBJECTIVES: This study compared health service use and satisfaction with health care among older adults living in urban vs rural counties in North Carolina. METHODS: A stratified random sample of 4162 residents of one urban and four rural counties of North ... Full text Link to item Cite

Sleep complaints in older adults: a racial comparison.

Journal Article J Gerontol A Biol Sci Med Sci · September 1995 BACKGROUND: Sleep complaints have been reported in epidemiologic studies to be more frequent in late life, among females, among the physically impaired, and among persons experiencing psychiatric disorders. To date, however, no studies have reported a raci ... Full text Link to item Cite

Black-white and urban-rural differences in stability of household composition among elderly persons.

Journal Article J Gerontol B Psychol Sci Soc Sci · September 1995 The dynamic nature of household composition in a population of elderly persons, with particular focus on Black-White and urban-rural differences, is described in this study. The Duke EPESE is a stratified, random household sample (N = 4,162) of elderly per ... Full text Link to item Cite

Depressive symptoms in the elderly: association with total white blood cell count.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · September 1995 1. The white blood cell (WBC) count in those with high depressive symptoms and non-depressed participants in the Established Populations for Epidemiologic Studies of the Elderly (EPESE) were compared. 2. Of 3769 participants 10.8% had high depressive sympt ... Full text Link to item Cite

Sleep complaints among elderly persons: an epidemiologic study of three communities.

Journal Article Sleep · July 1995 The frequencies of five common sleep complaints--trouble falling asleep, waking up, awaking too early, needing to nap and not feeling rested--were assessed in over 9,000 participants aged 65 years and older in the National Institute on Aging's multicentere ... Full text Link to item Cite

Behavioral and psychosocial predictors of physical performance: MacArthur studies of successful aging.

Journal Article J Gerontol A Biol Sci Med Sci · July 1995 BACKGROUND: Performance-based measures of physical performance are examined for an older cohort of relatively high-functioning men and women. The influences of baseline behavioral, social, and psychological characteristics on patterns of change in performa ... Full text Link to item Cite

Clinical and phenomenological comparisons of late-onset and early-onset depression.

Journal Article Am J Psychiatry · May 1995 OBJECTIVE: The authors examined the relationship between age at onset of first depressive episode and clinical features in elderly depressed patients. METHOD: They used data on age at onset and clinical features in 246 elderly depressed patients treated at ... Full text Link to item Cite

Medication taking behaviors in the high- and low-functioning elderly: MacArthur field studies of successful aging.

Journal Article Ann Pharmacother · April 1995 OBJECTIVE: To describe and compare medication-taking behaviors in the high- and low-functioning elderly living in the community. DESIGN: A cross-sectional design with data collected by interview. SETTING: The study included 5 counties in the southern Piedm ... Full text Link to item Cite

Antidepressant use in the elderly: association with demographic characteristics, health-related factors, and health care utilization.

Journal Article J Clin Epidemiol · March 1995 The characteristics of antidepressant use and its correlates were assessed in the four Established Populations for Epidemiologic Study of the Elderly (EPESE) communities (n = 13,074). Women were significantly more likely to be treated with an antidepressan ... Full text Link to item Cite

Does weight loss from middle age to old age explain the inverse weight mortality relation in old age?

Journal Article Am J Epidemiol · February 15, 1995 The authors examined body mass index at middle age, body mass index in old age, and weight change between age 50 years and old age in relation to mortality in old age. The study population from the Established Populations for Epidemiologic Studies of the E ... Full text Link to item Cite

Depressive symptomatology and hypertension-associated morbidity and mortality in older adults.

Journal Article Psychosom Med · 1995 This study determines, in a population of older adults with diagnosed hypertension, the concurrent association between depressive symptomatology and blood pressure control and the longitudinal association between depressive symptomatology and blood pressur ... Full text Link to item Cite

Religious coping and cognitive symptoms of depression in elderly medical patients.

Journal Article Psychosomatics · 1995 The investigators examined associations between depressive symptom type and religious coping in 832 consecutively admitted older medical inpatients. Cognitive symptoms of depression, but not somatic symptoms, were related to religious coping. Boredom, loss ... Full text Link to item Cite

Geriatric syndromes: An introduction

Journal Article Psychiatric Services · January 1, 1995 Full text Cite

The boundary of social phobia. Exploring the threshold.

Journal Article Arch Gen Psychiatry · December 1994 BACKGROUND: Individuals with subthreshold social phobia (SSP) in the community are characterized relative to nonphobic, healthy controls (C), and diagnosed social phobics (SP). METHODS: Data from 1488 subjects from the Duke University Epidemiological Catch ... Full text Link to item Cite

The impact of depressive symptomatology on physical disability: MacArthur Studies of Successful Aging.

Journal Article Am J Public Health · November 1994 OBJECTIVES: The purpose of these analyses was to test the hypothesis that depressive symptomatology affects the risk of onset of physical disability in high-functioning elderly adults. METHODS: The data come from the MacArthur Study of Successful Aging, a ... Full text Link to item Cite

Investigation of antiestrogenic properties of unleaded gasoline in female mice.

Journal Article Toxicol Appl Pharmacol · August 1994 Chronic exposure of female B6C3F1 mice to a high concentration of unleaded gasoline (UG) vapor induced liver tumors and caused uterine changes suggestive of estrogen antagonism. These effects of UG may be related, since estrogens inhibit hepatocarcinogenes ... Full text Link to item Cite

Depression in the elderly.

Journal Article Hosp Pract (Off Ed) · July 15, 1994 Presentation differs from that in the young, as does choice of therapy, which tends to be empiric. The tricyclics are considered the best treatment, although electroconvulsive therapy may be preferable in severe delusional depression. ... Full text Link to item Cite

The prevalence and distribution of major depression in a national community sample: the National Comorbidity Survey.

Journal Article Am J Psychiatry · July 1994 OBJECTIVE: Major depression is a frequent and disabling psychiatric disorder in the United States. This report examines the prevalence and risk factor profile of both pure and comorbid major depression according to data from the National Comorbidity Survey ... Full text Link to item Cite

Age and functional correlations of markers of coagulation and inflammation in the elderly: functional implications of elevated crosslinked fibrin degradation products (D-dimers).

Journal Article J Am Geriatr Soc · July 1994 OBJECTIVE: To measure markers of inflammation in a cohort of young and old subjects and relate these findings to the functional level of the individuals. DESIGN: For the pilot study, blood samples were obtained from 18 young (age 20-35 years) and 18 old (a ... Full text Link to item Cite

Religious affiliation and psychiatric disorder among Protestant baby boomers.

Journal Article Hosp Community Psychiatry · June 1994 OBJECTIVE: The authors examined the relationship between religious affiliation and psychiatric disorder among Protestant members of the baby-boom generation (those born between 1945 and 1966) who resided in the Piedmont area of North Carolina. METHODS: Dat ... Full text Link to item Cite

Estimating increment-decrement life tables with multiple covariates from panel data: the case of active life expectancy.

Journal Article Demography · May 1994 A fundamental limitation of current multistate life table methodology-evident in recent estimates of active life expectancy for the elderly-is the inability to estimate tables from data on small longitudinal panels in the presence of multiple covariates (s ... Link to item Cite

Self-rated health and mortality in the high-functioning elderly--a closer look at healthy individuals: MacArthur field study of successful aging.

Journal Article J Gerontol · May 1994 BACKGROUND: This study tested the predictive value of self-rated health on 3-year mortality, with attention focused on healthy, high-functioning elders. METHODS: Data from the MacArthur Field Study of Successful Aging were utilized. Subjects were 70-79-yea ... Full text Link to item Cite

Predicting changes in physical performance in a high-functioning elderly cohort: MacArthur studies of successful aging.

Journal Article J Gerontol · May 1994 BACKGROUND: Performance-based measures of physical performance were examined for an older cohort of relatively high-functioning men and women. Relationships between baseline physical performance and sociodemographic and health status characteristics were a ... Full text Link to item Cite

Religious practices and alcoholism in a southern adult population.

Journal Article Hosp Community Psychiatry · March 1994 OBJECTIVE: The study examined associations between religious variables and alcohol abuse and dependence among 2,969 North Carolina residents aged 18 to 97 who participated in the 1983-1984 National Institute of Mental Health Epidemiologic Catchment Area su ... Full text Link to item Cite

A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission.

Journal Article J Gerontol · March 1994 BACKGROUND: A short battery of physical performance tests was used to assess lower extremity function in more than 5,000 persons age 71 years and older in three communities. METHODS: Balance, gait, strength, and endurance were evaluated by examining abilit ... Full text Link to item Cite

Plasma homovanillic acid and performance on motor and cognitive tasks in community-dwelling elderly: MacArthur studies of successful aging.

Journal Article Neuropsychopharmacology · February 1994 To investigate the dopaminergic correlates of the aging-related motor and cognitive deficits, the dopamine metabolite homovanillic acid (HVA) in plasma was studied in a community-dwelling elderly cohort (n = 141). The results showed that hand-signature tim ... Full text Link to item Cite

Adult onset of severe and pervasive antisocial behavior: A distinct syndrome?

Journal Article Journal of Personality Disorders · January 1, 1994 Data from the Duke Epidemiologic Catchment Area (ECA) study were used to determine if persons reporting a pervasive pattern of severe adult antisocial behavior always report a similar pattern of antisocial behavior in childhood. Roughly half of persons rep ... Full text Cite

Sex and depression in the National Comorbidity Survey. II: Cohort effects.

Journal Article J Affect Disord · January 1994 Data from a nationally representative sample of the general population are used to study cohort differences in the prevalence of DSM-III-R Major Depressive Episode (MDE). We document increasing lifetime prevalence of MDE among both men and women in more re ... Full text Link to item Cite

The health burden of diabetes for the elderly in four communities.

Journal Article Public Health Rep · 1994 Although diabetes is a common health problem of the elderly, the impact of diabetes on health and functioning in older persons is not well established. The purpose of this analysis was to identify health conditions accompanying diabetes in four samples of ... Link to item Cite

Social ties and support and neuroendocrine function: The MacArthur studies of successful aging

Journal Article Annals of Behavioral Medicine · January 1, 1994 Data from a community-based, relatively high-functioning cohort of men and women, aged 70-79, were used to test hypotheses relating the quantity and quality of social relationships to levels of urinary norepinephrine, epinephrine, and cortisol. For men, mu ... Cite

Depression and smoking cessation in older adults: a longitudinal study.

Journal Article J Am Geriatr Soc · December 1993 OBJECTIVE: To explore the relationship of smoking cessation and depression. DESIGN: Cohort study with 3 years of follow-up. SETTING: North Carolina community of the Established Populations for the Epidemiologic Studies of the Elderly. PARTICIPANTS: Stratif ... Full text Link to item Cite

Profile of depressive symptoms in younger and older medical inpatients with major depression.

Journal Article J Am Geriatr Soc · November 1993 OBJECTIVE: To examine and compare the profile of cognitive symptoms, somatic symptoms, and somatic complaints in younger and older medical inpatients diagnosed with major depressive disorder (MDD). DESIGN: Cross-sectional cohort. PATIENTS AND SETTING: Male ... Full text Link to item Cite

High, usual and impaired functioning in community-dwelling older men and women: findings from the MacArthur Foundation Research Network on Successful Aging.

Journal Article J Clin Epidemiol · October 1993 The objective of this study is to determine the range of complex physical and cognitive abilities of older men and women functioning at high, medium and impaired ranges and to determine the psychosocial and physiological conditions that discriminate those ... Full text Link to item Cite

The epidemiology of social phobia: findings from the Duke Epidemiological Catchment Area Study.

Journal Article Psychol Med · August 1993 Social phobia was studied in a North Carolina community, using DSM-III criteria. Two kinds of comparison were made: social phobia v. non-social phobia, and comorbid social phobia v. non-comorbid social phobia. Six-month and lifetime prevalence rates were 2 ... Full text Link to item Cite

Educational status and active life expectancy among older blacks and whites.

Journal Article N Engl J Med · July 8, 1993 BACKGROUND AND METHODS: Persons of low socioeconomic status are known to have reduced life expectancy. In a study of the relation of socioeconomic status to disability-free or active life expectancy among older persons, we analyzed prospectively gathered d ... Full text Link to item Cite

Measured versus estimated creatinine clearance in a high-functioning elderly sample: MacArthur Foundation Study of Successful Aging.

Journal Article J Am Geriatr Soc · July 1993 OBJECTIVE: To assess the validity of several equations for estimating creatinine clearance in a large sample of high-functioning, community-dwelling elderly. DESIGN: Serum and 12-hour urine samples were collected and assayed for creatinine using the Jaffe ... Full text Link to item Cite

Intercommunity variations in the association between social ties and mortality in the elderly. A comparative analysis of three communities.

Journal Article Ann Epidemiol · July 1993 Identical measures of social ties obtained from three community-based cohorts aged 65 and over from East Boston, MA; New Haven, CT; and two rural counties in Iowa permit the first direct cross-community comparison of the hypothesis that social isolation in ... Full text Link to item Cite

Does age make a difference in the effects of physical health and social support on the outcome of a major depressive episode?

Journal Article Am J Psychiatry · May 1993 OBJECTIVE: The authors examined the effects of physical health and social support on 6-month outcome of a major depressive episode in 67 patients who were less than 60 years old and 46 patients who were 60 years old or older. They hypothesized that despite ... Full text Link to item Cite

Psychiatric disorders in adult children of alcoholics: data from the Epidemiologic Catchment Area project.

Journal Article Am J Psychiatry · May 1993 OBJECTIVE: The authors examined differences in the prevalence of psychiatric disorders in individuals who did or did not have alcoholic parents. METHOD: They used data from the National Institute of Mental Health Epidemiologic Catchment Area project, speci ... Full text Link to item Cite

Reducing antipsychotic drug use in nursing homes. A controlled trial of provider education.

Journal Article Arch Intern Med · March 22, 1993 OBJECTIVE: In the United States, 20% or more of nursing home residents receive antipsychotic drugs, primarily for the behavioral manifestations of dementia. This high level of use of drugs with substantial toxicity has engendered a strong and persistent co ... Link to item Cite

CES-D: cutpoint or change score?

Journal Article J Am Geriatr Soc · March 1993 Full text Link to item Cite

Established populations for epidemiologic studies of the elderly: study design and methodology.

Journal Article Aging (Milano) · February 1993 A project initiated by the intramural Epidemiology, Demography and Biometry Program of the National Institute on Aging, entitled "Established Populations for Epidemiologic Studies of the Elderly" (EPESE), has developed information on death, chronic conditi ... Full text Link to item Cite

Religion and anxiety disorder: An examination and comparison of associations in young, middle-aged, and elderly adults

Journal Article Journal of Anxiety Disorders · January 1, 1993 We examined and compared associations between religious variables and anxiety disorders in 1025 young (ages 18 to 39), 645 middle-aged (ages 40 to 59), and 1299 elderly (ages 60 to 97) community-dwelling adults who participated in Wave II of the Piedmont N ... Full text Cite

Abbreviating the Duke Social Support Index for use in chronically ill elderly individuals.

Journal Article Psychosomatics · 1993 The 35-item Duke Social Support Index (DSSI) measures multiple dimensions of social support and has been used extensively in cross-sectional and longitudinal studies of aging. Epidemiological studies of chronically ill, frail elderly individuals often wish ... Full text Link to item Cite

Black/white differences in hypertension in the elderly: an epidemiologic analysis in central North Carolina.

Journal Article Am J Epidemiol · January 1, 1993 Hypertension in blacks, compared with whites, occurs at higher prevalence rates, is more severe, and carries a worse prognosis for cardiovascular morbidity and mortality. The authors examined the degree to which black/white differences in hypertension in t ... Full text Link to item Cite

Should physicians screen for depression in elderly medical inpatients?: Results of a decision analysis.

Journal Article Int J Psychiatry Med · 1993 OBJECTIVE: We wish to determine whether or not elderly medical inpatients should be screened for depressive disorder using either 1) a self-rated depression scale (Geriatric Depression Scale), 2) "usual clinical assessment," or 3) neither, assuming that tr ... Full text Link to item Cite

Rhythmicity and response to A.M. and P.M. CRH challenge in elderly subjects.

Journal Article Neurobiol Aging · 1993 Cortisol and ACTH exhibit circadian rhythmicity, peaking in the early morning. These peaks are associated with increased activity and alertness. We sought to determine whether self-reported daily rhythms predict outcome of a.m. and p.m. CRH challenge in el ... Full text Link to item Cite

Sex and depression in the National Comorbidity Survey. I: Lifetime prevalence, chronicity and recurrence.

Journal Article J Affect Disord · 1993 Basic epidemiologic prevalence data are presented on sex differences in DSM-III-R major depressive episodes (MDE). The data come from the National Comorbidity Survey (NCS), the first survey in the U.S. to administer a structured psychiatric interview to a ... Full text Link to item Cite

Diagnosis and treatment of depression in late life: the NIH Consensus Development Conference Statement.

Journal Article Psychopharmacol Bull · 1993 The National Institutes of Health Consensus Development Conference on Diagnosis and Treatment of Depression in Late Life brought together biomedical and behavioral scientists, surgeons, and other health care professionals as well as the public to address t ... Link to item Cite

DIAGNOSIS AND EPIDEMIOLOGY OF DEPRESSION

Journal Article CLINICAL NEUROSCIENCE · January 1, 1993 Link to item Cite

Religious coping and depression among elderly, hospitalized medically ill men.

Journal Article Am J Psychiatry · December 1992 OBJECTIVE: The investigators examined the frequency of religious coping among older medical inpatients, the characteristics of those who use it, and the relation between this behavior and depression. METHOD: The subjects were 850 men aged 65 years and over ... Full text Link to item Cite

Religious affiliation and major depression.

Journal Article Hosp Community Psychiatry · December 1992 Data from the Duke Epidemiologic Catchment Area survey were used to examine the relationship between religious affiliation and major depression among 2,850 adults in the community. Religious affiliations were categorized into six groups: mainline Protestan ... Full text Link to item Cite

Screening for depression in hospitalized elderly medical patients: taking a closer look.

Journal Article J Am Geriatr Soc · October 1992 OBJECTIVE: To re-examine the test characteristics of the Geriatric Depression Scale (GDS) and the Brief Carroll Depression Rating Scale (BCDRS) in elderly medical inpatients, simulating the procedure followed by clinicians when using screening instruments. ... Full text Link to item Cite

William W.K. Zung, MDiv, MS, MD

Journal Article Journal of Clinical Psychopharmacology · August 1992 Full text Cite

Family history of psychiatric disorder and low self-confidence: predictors of depressive symptoms at 12-month follow-up.

Journal Article J Affect Disord · July 1992 We examined effects of two risk factors for depression, family psychiatric history and Low Self-Confidence, on (1) baseline characteristics of major depression and (2) depressive symptoms one year later. Subjects (N = 104) in the midst of a depressive epis ... Full text Link to item Cite

Epidemiology of geriatric affective disorders.

Journal Article Clin Geriatr Med · May 1992 Recent Epidemiologic Catchment area studies found the prevalence of major depression to be only about 1% in community-dwelling elders; other less severe depressive disorders, however, may be present in over 25% of this population. Furthermore, at least 800 ... Link to item Cite

Drug-use patterns among black and nonblack community-dwelling elderly.

Journal Article Ann Pharmacother · May 1992 OBJECTIVE: To describe and compare drug-use patterns among black and nonblack community-dwelling elderly. DESIGN: Survey. SETTING: Five-county urban and rural region in Piedmont, NC. PARTICIPANTS: Stratified probability household sample of 4164 community r ... Full text Link to item Cite

Sociocultural Factors in Sexual Assault: Comparison of Two Representative Samples of Women

Journal Article Journal of Social Issues · April 1992 In previous research, the lifetime prevalence of sexual assault among U.S. women ranges from less than 15% to more than 50%. Much of this variability is due to methodological differences across studies, but some of the inconsistency may be substant ... Full text Cite

Age and impaired subjective support. Predictors of depressive symptoms at one-year follow-up.

Journal Article J Nerv Ment Dis · March 1992 We followed a cohort of subjects (predominantly inpatients) suffering a major depressive episode in midlife and late-life for 1 year (N = 118). In this follow-up study, we examined three hypotheses. a) Elder subjects suffering major depression, compared wi ... Link to item Cite

The prevention of major depression in the elderly.

Journal Article Clin Geriatr Med · February 1992 Limited information is available regarding the relationship between elderly individuals and depression; but the clinician can anticipate problems in those who have had depression in the past, in those who are bereaved, in caretakers, and in patients with a ... Link to item Cite

A brief depression scale for use in the medically ill.

Journal Article Int J Psychiatry Med · 1992 OBJECTIVE: Using items from two existing depression scales, we have sought to develop a brief self-rated instrument for detecting major depressive disorder (M.D.D.) in medically ill, hospitalized patients. METHOD: Forty-two items from the Geriatric Depress ... Full text Link to item Cite

Self-rated depressive symptoms in medical inpatients: age and racial differences.

Journal Article Int J Psychiatry Med · 1992 One thousand and eleven men under age forty (n = 161) or over age sixty-four (n = 850) admitted to medical and neurological services of an acute care hospital were screened for depressive symptoms as part of the Durham VA Mental Health Survey. Thirty-three ... Full text Link to item Cite

Secretaries, depression and absenteeism

Journal Article Women and Health · 1992 This study examines the prevalence of Major Depressive Disorder; missed work; and mental health services use among secretaries and other women employed full-time. In a random sample of 3,484 women employed full-time, women employed as secretaries were sign ... Full text Cite

Issues in the treatment of major depression: Selection, efficacy, and safety

Journal Article Journal of Clinical Psychiatry · January 1, 1992 Cite

Diagnosis and treatment of depression in late life

Journal Article Journal of the American Medical Association · January 1, 1992 Full text Cite

Major depression in hospitalized medically ill older men: Documentation, management, and outcome

Journal Article International Journal of Geriatric Psychiatry · January 1, 1992 Fifty‐three hospitalized elderly men with medical illness were diagnosed with major depressive disorder and followed up for a mean of 2.3 months. Documentation and management of the depression by medical housestaff during the followup period were examined. ... Full text Cite

Occurrence of subcortical hyperintensities in elderly subjects with mania.

Journal Article Psychiatry Res · December 1991 In a retrospective study, brain magnetic resonance images of 12 patients with the onset of manic symptoms after the age of 50 years were compared to age- and sex-matched control subjects for the incidence, size, and location of subcortical hyperintensities ... Full text Link to item Cite

The association of age and depression among the elderly: an epidemiologic exploration.

Journal Article J Gerontol · November 1991 Advanced age among the elderly has been hypothesized to be a risk factor for depression, yet extant data do not uniformly support this hypothesis. The paucity of sufficiently large and representative samples of both the young-old and old-old and the failur ... Full text Link to item Cite

Adult vulnerability for psychiatric disorders: interactive effects of negative childhood experiences and recent stress.

Journal Article J Nerv Ment Dis · November 1991 The effects of negative childhood experiences on adult psychiatric status remain unclear because of inconsistent findings in previous studies. In this study, we examine the extent to which parental separation/divorce before the age of 10, parental death be ... Link to item Cite

Major depressive disorder in hospitalized medically ill patients: an examination of young and elderly male veterans.

Journal Article J Am Geriatr Soc · September 1991 OBJECTIVE: To study the epidemiology of depressive disorder in younger and older medical inpatients. DESIGN, PATIENTS, & SETTING: Depressive disorders were examined using the Diagnostic Interview Schedule in 116 young and 332 elderly medically ill men hosp ... Full text Link to item Cite

Post-traumatic stress disorder in the community: an epidemiological study.

Journal Article Psychol Med · August 1991 Post-traumatic stress disorder (PTSD) was studied in the Piedmont region of North Carolina. Among 2985 subjects, the lifetime and six month prevalence figures for PTSD were 1.30 and 0.44% respectively. In comparison to non-PTSD subjects, those with PTSD ha ... Full text Link to item Cite

Tricyclic antidepressant prescribing for nonpsychiatric disorders. An analysis based on data from the 1985 National Ambulatory Medical Care Survey.

Journal Article J Fam Pract · July 1991 BACKGROUND: Primary care physicians often do not document a psychiatric diagnosis when prescribing psychotropic medications. Recent literature suggests the potential benefit of tricyclic antidepressants (TCAs) in a number of nonpsychiatric conditions (low ... Link to item Cite

Benzodiazepine anti-anxiety agents: prevalence and correlates of use in a southern community.

Journal Article Am J Public Health · May 1991 BACKGROUND: Benzodiazepine anti-anxiety agents are the most widely prescribed psychotherapeutic drugs in the United States today. Recent evidence, however, suggests that their use may be decreasing. METHODS: We examine the population prevalence and correla ... Full text Link to item Cite

Training in Geriatric Psychiatry

Journal Article Academic Psychiatry · January 1, 1991 The objective of this study was to determine the extent and the barriers to expansion of geriatric psychiatry training in psychiatry training programs in the United States. We mailed a questionnaire to the training directors of all 216 psychiatry residency ... Full text Cite

Epidemiologic data and planning mental health services. A tale of two surveys.

Journal Article Soc Psychiatry Psychiatr Epidemiol · January 1991 The Epidemiologic Catchment Area Program (ECA) is the most comprehensive community and institutionalized epidemiologic data base currently available for mental health service planning. In this report, the authors compare the ECA with a previous community s ... Full text Link to item Cite

Clinical features in depression in old age: A case for minor depression

Journal Article Current Opinion in Psychiatry · January 1, 1991 An epidemiologic dilemma exists in the study of the prevalence of depression in late life. Though depressive symptoms are frequent, the diagnosis of major depression in both community and clinical populations is relatively rare. Minor depression, a subsynd ... Full text Cite

Subjective social support and depressive symptoms in major depression: separate phenomena or epiphenomena.

Journal Article J Psychiatr Res · 1991 One hundred and twenty-five middle-aged and elderly adults suffering from a major depressive episode were evaluated during the index episode and at six and twelve month follow-up. Subjective (emotional) social support and depressive symptoms (CES-D) were e ... Full text Link to item Cite

Suicide risk factors in the elderly: An epidemiological study

Journal Article Journal of Geriatric Psychiatry · January 1, 1991 Cite

Social outcomes related to age of onset among psychiatric disorders.

Journal Article J Consult Clin Psychol · December 1990 Analyses are presented that examine the impact of a diagnosis of affective disorder, anxiety disorder, and substance abuse before and after age 20 on multiple measures of education, socioeconomic and employment status, childbearing, marital status, and ins ... Full text Link to item Cite

Depression, disability days, and days lost from work in a prospective epidemiologic survey.

Journal Article JAMA · November 21, 1990 We describe the relationship of depression and depressive symptoms to disability days and days lost from work in 2980 participants in the Epidemiologic Catchment Area Study in North Carolina after 1 year of follow-up. Compared with asymptomatic individuals ... Link to item Cite

Elevated plasma concentrations of alpha 1-acid glycoprotein, a putative endogenous inhibitor of the tritiated imipramine binding site, in depressed patients.

Journal Article Arch Gen Psychiatry · April 1990 The plasma concentration of alpha 1-acid glycoprotein, a putative endogenous inhibitor of the site labeled by tritiated imipramine, was measured by a radial immunodiffusion assay in 36 normal human volunteers and 51 drug-free patients who fulfilled DSM-III ... Full text Link to item Cite

Sexual assault and psychiatric disorders among a community sample of women.

Journal Article Am J Psychiatry · March 1990 The authors examined the relationships between sexual assault and psychiatric disorders in a sample of 1,157 women 18-64 years old in the North Carolina site of the NIMH Epidemiologic Catchment Area Program. The results suggest that sexual assault is a ris ... Full text Link to item Cite

Estimating the prevalence of borderline personality disorder in the community

Journal Article Journal of Personality Disorders · January 1, 1990 The authors use a new diagnostic algorithm derived from the Diagnostic Interview Schedule (the DIS/Borderline Index) to identify a borderline personality disorder among 19- to 55-year-olds at the Duke site of the Epidemiologic Catchment Area project. A cri ... Full text Cite

Anticipating the future and change.

Journal Article J Public Health Dent · 1990 As in all of medicine, there are basic assumptions underlying the present system of dental education and delivery. These basic assumptions are facing challenges due in part to the marked reduction in the incidence of caries and the development of more effe ... Full text Link to item Cite

Demographic and health characteristics of elderly smokers: results from established populations for epidemiologic studies of the elderly.

Journal Article Am J Prev Med · 1990 Although smoking has been shown to be associated with excess morbidity and mortality, most studies have focused on young and middle-aged rather than elderly smokers. We examined the demographic characteristics and physical and psychological health of elder ... Link to item Cite

Alternative models of the stress buffering hypothesis.

Journal Article Am J Community Psychol · October 1989 The interactive effects of life events and social support on a DSM-III diagnosis of major depressive episode and on number of depressive symptoms were examined. Data are from a stratified random sample of 3,732 community-dwelling adults. The paper focuses ... Full text Link to item Cite

The prevalence of major depression in black and white adults in five United States communities.

Journal Article Am J Epidemiol · October 1989 There have been inconsistent findings on race differences in the rates and nature of depression, which are probably due to methodological differences between studies. Data are presented on the prevalence of major depression in white and black adults from t ... Full text Link to item Cite

Major depression in later life.

Journal Article Hosp Pract (Off Ed) · September 30, 1989 Link to item Cite

Antisocial and related disorders in a southern community. An application of grade of membership analysis.

Journal Article J Nerv Ment Dis · September 1989 Symptoms of antisocial personality disorder (ASPD) and of psychiatric conditions reported to be related to ASPD were subjected to grade of membership analysis, a relatively new procedure for medical classification, to identify the pure types that would emp ... Full text Link to item Cite

The association between depressive symptoms and mortality among older participants in the Epidemiologic Catchment Area-Piedmont Health Survey.

Journal Article J Gerontol · July 1989 The association between depression and two-year mortality risk was assessed in 1,606 elderly community participants in the 1982-83 Epidemiologic Catchment Area-Piedmont Health Survey. Two depression measures were formed from the Diagnostic Interview Schedu ... Full text Link to item Cite

Survival and health care utilization in elderly medical inpatients with major depression.

Journal Article J Am Geriatr Soc · July 1989 Forty-one elderly medical inpatients with active major depression were matched with nondepressed controls from the same population. Survival and health care utilization were examined during a mean follow-up period of five months. Cases and controls were ma ... Full text Link to item Cite

Depression in the elderly.

Journal Article N Engl J Med · June 15, 1989 Full text Link to item Cite

The effects of childhood parental death and divorce on six-month history of anxiety disorders.

Journal Article Br J Psychiatry · June 1989 Duke Epidemiologic Catchment Area (ECA) data were used to examine the relationships between: (a) early childhood maternal death, paternal death, and parental separation/divorce, and (b) six-month DIS/DSM-III diagnoses of agoraphobia with and without panic ... Full text Link to item Cite

Social support and the outcome of major depression.

Journal Article Br J Psychiatry · April 1989 One hundred and fifty middle-aged and elderly adults with a diagnosis of major depression were assessed initially as in-patients, and were reinterviewed 6-32 months later. Both size of social network and subjective social support were significant predictor ... Full text Link to item Cite

Reduced inhibitory effect of imipramine on radiolabeled serotonin uptake into platelets in geriatric depression.

Journal Article Biol Psychiatry · March 15, 1989 Tritiated imipramine binding, uptake of radiolabeled serotonin, and inhibition of uptake by imipramine in vitro were studied in platelets obtained from four groups of subjects: (1) normal controls 50 years of age or younger, (2) patients with major depress ... Full text Link to item Cite

Dizziness in a community elderly population.

Journal Article J Am Geriatr Soc · February 1989 Dizziness was studied in 1,622 community-dwelling adults aged 60 and older who were interviewed as part of the Duke Epidemiologic Catchment Area study. The lifetime prevalence of dizziness (defined as severe enough to see a physician, to take a medication, ... Full text Link to item Cite

Identification of borderline personality disorder with the NIMH Diagnostic Interview Schedule.

Journal Article Am J Psychiatry · February 1989 No lay-administered interviews are currently available to identify persons with borderline personality disorder. The authors studied 79 subjects with the NIMH Diagnostic Interview Schedule (DIS), a lay-administered interview, and the Diagnostic Interview f ... Full text Link to item Cite

Religious affiliations in mental health research samples as compared with national samples.

Journal Article J Nerv Ment Dis · February 1989 Religious affiliations of patients in research samples in four major psychiatric journals for the years 1978-1982 were compared with those reported in national samples. Protestants and the unaffiliated were underrepresented, whereas Jewish persons were ove ... Full text Link to item Cite

Depression in the elderly.

Journal Article N Engl J Med · January 19, 1989 Full text Link to item Cite

Somatization symptoms in the community: a rural/urban comparison.

Journal Article Psychosomatics · 1989 Somatization is conceptualized as a bodily or somatic expression of psychic distress. Unexplained somatic symptomatology was assessed by use of the National Institute of Mental Health Diagnostic Interview Schedule among community respondents in the Piedmon ... Full text Link to item Cite

Antidepressant use in elderly medical inpatients: lessons from an attempted clinical trial.

Journal Article J Gen Intern Med · 1989 The authors conducted a clinical trial to examine the efficacy and safety of nortriptyline in the treatment of major depression in elderly medical inpatients. The diagnosis of major depression was made by a psychiatrist in 41 of 680 patients 65 years of ag ... Full text Link to item Cite

Major depression and the NIMH Diagnostic Interview Schedule: validation in medically ill hospitalized patients.

Journal Article Int J Psychiatry Med · 1989 The authors validate the usefulness of the Diagnostic Interview Schedule (DIS) in prevalence studies of major depression (MD) in medically ill male veterans. The affective disorders portion of the DIS was administered by a trained interviewer to a represen ... Full text Link to item Cite

The construct validity of the ischemic score of Hachinski for the detection of dementias.

Journal Article J Neuropsychiatry Clin Neurosci · 1989 Two hundred forty-one nursing home patients from the National Nursing Home Survey Pretest were assessed using the Ischemic Score of Hachinski. Medical chart diagnoses were used to classify those with and without dementia. The Mini-Mental State Examination ... Full text Link to item Cite

Depression in late life: an update.

Journal Article Annu Rev Gerontol Geriatr · 1989 Clinical and basic research units depressive disorders in late life have expanded our knowledge base appreciably in recent years. In the process, some clinical impressions have been confirmed (e.g., the association of depression and physical disorders); ot ... Full text Link to item Cite

The epidemiology of depression in late life.

Journal Article J Geriatr Psychiatry · 1989 In contrast to previous observations, which had indicated an increased prevalence of depressive symptoms among the elderly, recent epidemiological studies have shown a decreasing current and lifetime prevalence after age 20 or 30. The question whether depr ... Link to item Cite

A statistical analysis of the classification of depression in a mixed community and clinical sample.

Journal Article J Affect Disord · 1989 Depressive symptoms in three samples are assessed using grade-of-membership analysis to clarify the distribution of depressive symptoms across traditional affective diagnoses. The technique is used to examine whether depressive symptoms and symptoms freque ... Full text Link to item Cite

Anxiety as an outcome symptom of depression in elderly and middle‐aged adults

Journal Article International Journal of Geriatric Psychiatry · January 1, 1989 Early morning anxiety was reported as a symptom in 32.1% of 131 elderly and middle‐aged patients hospitalized for depression one to two years following hospitalization. Two‐thirds of those patients complaining of early morning anxiety also complained of an ... Full text Cite

Depression in late life

Journal Article Current Opinion in Psychiatry · January 1, 1989 Full text Cite

Depressive symptoms and depressive diagnoses in a community population. Use of a new procedure for analysis of psychiatric classification.

Journal Article Arch Gen Psychiatry · December 1988 A multivariate classification technique was used to examine whether depressive symptoms and symptoms frequently associated with depressive disorders would cluster into recognizable syndromes that parallel traditional DSM-III psychiatric diagnoses. An analy ... Full text Link to item Cite

Scoring nonresponse on the Mini-Mental State Examination.

Journal Article Psychol Med · November 1988 Alternative procedures for coding nonresponse on the Mini-Mental State Examination as error or as correct) results in different classification of 13% of a random sample of 1931 subjects aged 60 and over. Comparison of responders' and nonresponders' ability ... Full text Link to item Cite

Marked reduction in the number of platelet-tritiated imipramine binding sites in geriatric depression.

Journal Article Arch Gen Psychiatry · October 1988 The number (Bmax) and affinity (Kd) of platelet-tritiated imipramine binding sites was determined in young and middle-aged controls 50 years of age and younger (n = 25), elderly normal controls over 60 years of age (n = 18), patients who fulfilled DSM-III ... Full text Link to item Cite

Depression in elderly hospitalized patients with medical illness.

Journal Article Arch Intern Med · September 1988 Depressive symptoms and disorders were identified by structured psychiatric interview in 130 consecutively admitted male inpatients aged 70 years and over. Major depression was found in 11.5% and other depressive syndromes in 23%. While depressive symptoms ... Link to item Cite

Self-rated depression scales and screening for major depression in the older hospitalized patient with medical illness.

Journal Article J Am Geriatr Soc · August 1988 Until now, no self-rated depression scale had been validated as a screening measure for major depression in the older patient hospitalized with medical illness. The present report establishes the validity of two brief, easily administered depression screen ... Full text Link to item Cite

Relationship of health and demographic characteristics to Mini-Mental State examination score among community residents.

Journal Article Psychol Med · August 1988 Mini-Mental State findings from an age 60+ random community sample (N = 1681) indicate that score is related to education, age and race (but not sex) and to functional status, but not to selected aspects of physical or mental health. Adjustment for demogra ... Full text Link to item Cite

Dr. Blazer's Response

Journal Article American Journal of Public Health · August 1988 Full text Cite

Trends in US suicide mortality rates 1968 to 1982: race and sex differences in age, period and cohort components.

Journal Article Int J Epidemiol · June 1988 Interest has recently emerged in increases in suicide among US teenagers. Nonetheless suicide remains one of the major causes of death among the fastest growing components of the US population--the elderly. We examine the trends in US age-specific suicide ... Full text Link to item Cite

Age differences in life event qualities: Multivariate controlled analyses

Journal Article Journal of Community Psychology · April 1988 Full text Cite

New concepts in the diagnosis and management of depression.

Journal Article Compr Ther · April 1988 The diagnosis and therapy of the depressive disorders has entered a new era in the 80s. Though primarily driven by breakthroughs in the neurosciences, such as neuroendocrinology, neurochemistry, and psychopharmacology, the increased sophistication of our d ... Link to item Cite

Home health care: house calls revisited.

Journal Article Am J Public Health · March 1988 Full text Link to item Cite

Affective disorders in five United States communities.

Journal Article Psychol Med · February 1988 Results on the age/sex specific prevalence of DSM-III affective disorders from the NIMH Epidemiologic Catchment Area Study (ECA), a probability sample of over 18,000 adults from five United States communities, are presented. The cross-site means for bipola ... Full text Link to item Cite

Detection and treatment of major depression in older medically ill hospitalized patients.

Journal Article Int J Psychiatry Med · 1988 While major depression is common among medically ill older inpatients, little is known about the frequency of detection or appropriate treatment in this population. In the present study, 171 consecutive men age seventy and over admitted to the medical and ... Full text Link to item Cite

Age differences in life events: a multivariate controlled analysis.

Journal Article Int J Aging Hum Dev · 1988 Effects of age on the distribution of specific life events experienced during the past year by community-based adults were examined controlling for sex, race, education, marital status, and place of residence. The controlled analyses were done using logist ... Full text Link to item Cite

Social support as a predictor of the natural history of major depression

Journal Article Journal of Psychiatric Research · January 1, 1988 Full text Cite

Reducing antipsychotic drug prescribing for nursing home patients: a controlled trial of the effect of an educational visit.

Journal Article Am J Public Health · November 1987 We conducted a statewide, controlled trial of the efficacy of an educational visit in reducing antipsychotic drug prescribing for nursing home patients. Frequent antipsychotic drug prescribers were visited by a trained physician counselor who stressed know ... Full text Link to item Cite

Major depression with melancholia: a comparison of middle-aged and elderly adults.

Journal Article J Am Geriatr Soc · October 1987 Patients admitted to an inpatient psychiatric service were screened to identify middle-aged (35 to 50 years of age) and elderly (60 years of age and over) patients suffering from a major depressive episode with melancholia. Thirty-seven subjects (18 middle ... Full text Link to item Cite

Stressful life events and the onset of a generalized anxiety syndrome.

Journal Article Am J Psychiatry · September 1987 In a study of 2,902 subjects from the National Institute of Mental Health Epidemiologic Catchment Area Project in North Carolina, the association between life events and the onset of new cases of generalized anxiety syndrome varied across demographic subgr ... Full text Link to item Cite

Alcohol abuse and dependence in the rural South.

Journal Article Arch Gen Psychiatry · August 1987 We studied rural-urban differences in the prevalence of Diagnostic Interview Schedule (DIS)-DSM-III alcohol abuse or dependence from a community survey (part of the Epidemiologic Catchment Area program) of 3921 adults living in the Piedmont of North Caroli ... Full text Link to item Cite

Suicide in middle age and later life: sex and race specific life table and cohort analyses.

Journal Article J Gerontol · March 1987 Cross-temporal data on suicide for the period 1962 to 1981 from the National Center for Health Statistics were analyzed. These data were used to estimate period and cohort suicide rates for the four middle-aged and elderly groups (ages 45 to 64, 65 to 74, ... Full text Link to item Cite

Somatization disorder in the community. A study of diagnostic concordance among three diagnostic systems.

Journal Article J Nerv Ment Dis · January 1987 Somatization disorder, the presentation of multiple somatic complaints in multiple organ systems, can be diagnosed by three roughly comparable diagnostic systems: the Washington University Feighner criteria, the Research Diagnostic Criteria, and DSM-III cr ... Full text Link to item Cite

A study of somatization disorder in a community population utilizing grade of membership analysis.

Journal Article Psychiatr Dev · 1987 A new multivariate analytical technique for the analysis of medical classification, Grade of Membership analysis, is utilized to examine somatization disorder in a community population. The authors examine whether somatic symptoms will cluster into a clini ... Link to item Cite

Hospital treatment of anorexia nervosa: A 25 year retrospective study form 1958 to 1982

Journal Article International Journal of Eating Disorders · January 1, 1987 In order to characterize changes in the presenting symptomatology and treatment of anorexia nervosa (AN), the hospital charts of 76 anorexia nervosa patients were reviewed from three time periods: (1) 1958‐1962, (II) 1968‐1972, and (III) 1978‐1982. In peri ... Full text Cite

Reducing long-term diazepam prescribing in office practice. A controlled trial of educational visits.

Journal Article JAMA · November 14, 1986 We conducted a controlled, statewide trial of the efficacy of an educational visit by a physician counselor in the reduction of diazepam prescribing in outpatient practice. A novel aspect of this trial was the provision of a schedule for gradual withdrawal ... Link to item Cite

Somatization disorder in a community population.

Journal Article Am J Psychiatry · November 1986 The data recently collected in the Piedmont region of North Carolina as part of the National Institute of Mental Health Epidemiologic Catchment Area Program were used to examine somatization disorder in a community population. The authors found an adjusted ... Full text Link to item Cite

Premenstrual symptoms in black and white community samples.

Journal Article Am J Psychiatry · November 1986 Premenstrual syndrome specialty clinics are reported to be almost exclusively attended by white women. This racial discrepancy has raised the question of whether there is a lower prevalence or severity of symptoms during the premenstruum among black women. ... Full text Link to item Cite

The economic burden of depression.

Journal Article Gen Hosp Psychiatry · November 1986 This article provides estimates of direct treatment costs and indirect costs from lost productivity associated with the morbidity and mortality of depression. Data are based on epidemiologic estimates of the prevalence of major depressive illness and on th ... Full text Link to item Cite

Psychosocial risk factors and urban/rural differences in the prevalence of major depression.

Journal Article Br J Psychiatry · September 1986 The Piedmont Health Survey interviewed 3798 adult community residents in a region of North Carolina. Current major depression was nearly three times more common in the urban than in the rural counties; rural residence decreased the risk of major depression ... Full text Link to item Cite

Comparison of lifetime psychiatric diagnoses in Premenstrual Syndrome Clinic and community samples.

Journal Article J Nerv Ment Dis · September 1986 The purpose of this investigation was to obtain information about lifetime psychiatric diagnoses of women seeking treatment for premenstrual syndrome. The National Institute for Mental Health Diagnostic Interview Schedule (DIS) was administered to 223 wome ... Full text Link to item Cite

Caring for the older adult: avoiding the lumping syndrome.

Journal Article J Tenn Med Assoc · September 1986 Link to item Cite

Somatization disorder in a US southern community: use of a new procedure for analysis of medical classification.

Journal Article Psychol Med · August 1986 The authors examine somatization disorder in a community population, using grade of membership analysis, a new multivariate analytical technique for the analysis of medical classification. The technique is used to examine whether somatic symptoms will clus ... Full text Link to item Cite

Suicide in late life. Review and commentary.

Journal Article J Am Geriatr Soc · July 1986 Increasing attention has been directed to recent increases in suicide rates for children, adolescents, and young adults. Nevertheless, persons 65 years and older continue to commit suicide at a higher rate than any other age group in the United States. In ... Full text Link to item Cite

Systematic analysis of research on religious variables in four major psychiatric journals, 1978-1982.

Journal Article Am J Psychiatry · March 1986 The authors conducted a systematic analysis of quantitative research on religious variables found in four psychiatric journals between 1978 and 1982. Of the 2,348 psychiatric articles reviewed, 59 included a quantified religious variable. In this research, ... Full text Link to item Cite

Developing a screening index for community studies of somatization disorder.

Journal Article J Psychiatr Res · 1986 Despite the low prevalence of somatization disorder in the community, the section of the Diagnostic Interview Schedule used to make the diagnosis--as well as previous diagnostic interviews for the related diagnoses of hysteria, and Briquet's syndrome--is q ... Full text Link to item Cite

Psychiatric disorders. A rural/urban comparison.

Journal Article Arch Gen Psychiatry · July 1985 We studied rural/urban differences in the prevalence of nine psychiatric disorders from a community survey (part of the Epidemiologic Catchment Area Program) of 3,921 adults living in the Piedmont of North Carolina. Crude comparisons disclosed that major d ... Full text Link to item Cite

The NIMH Epidemiologic Catchment Area program. Historical context, major objectives, and study population characteristics.

Journal Article Arch Gen Psychiatry · October 1984 The National Institute of Mental Health multisite Epidemiologic Catchment Area (ECA) program is described in the context of four previous psychiatric epidemiologic surveys that included a combined total of 4,000 subjects from Stirling County, the Baltimore ... Full text Link to item Cite

Epidemiology of persecutory ideation in an elderly population in the community.

Journal Article Am J Psychiatry · September 1984 Of 997 elderly people living in the community, 40 (4%) were found to have generalized persecutory ideation. Sensory deficits and cognitive impairment were significant risk factors for the development of this symptom complex. Generalized persecutory ideatio ... Full text Link to item Cite

Family therapy and the dementia patient.

Journal Article Am Fam Physician · May 1984 Caring for a relative with senile dementia often results in family problems. In this situation, the family usually turns to the physician for evaluation, advice, treatment and support. A specific strategy for family intervention is helpful and does not req ... Link to item Cite

ARE DEPRESSIVE SYMPTOMS DIFFERENT IN THE DEPRESSED ELDERLY

Journal Article GERONTOLOGIST · January 1, 1984 Link to item Cite

The NIMH epidemiologic catchment area program

Journal Article Archives of General Psychiatry · 1984 The National Institute of Mental Health multisite Epidemiologic Catchment Area (ECA) program is described in the context of four previous psychiatric epidemiologic surveys that included a combined total of 4,000 subjects from Stirling County, the Baltimore ... Cite

Community adjustment of older schizophrenics.

Journal Article J Clin Psychol · March 1983 Community adjustment among older schizophrenics is a virtually unresearched area. This study addressed two questions related to this problem: Does the community adjustment of older schizophrenics differ from that of younger schizophrenics?, and Do "older" ... Full text Link to item Cite

Impact of late-life depression on the social network.

Journal Article Am J Psychiatry · February 1983 The author tested the hypothesis that a major depressive disorder contributes to a decline in social support by studying data from 331 subjects 65 years of age and older who had been selected at random from a larger community group and screened for a major ... Full text Link to item Cite

The risk of anticholinergic toxicity in the elderly: a study of prescribing practices in two populations.

Journal Article J Gerontol · January 1983 The potential for anticholinergic toxicity due to concurrent use of medications was assessed among 5,902 continuous nursing home residents and a comparable group of ambulatory patients. During the study year nearly 60% of the nursing home residents and 23% ... Full text Link to item Cite

MID LIFE AND LATER LIFE

Journal Article JOURNAL OF PSYCHIATRIC EDUCATION · January 1, 1983 Link to item Cite

The epidemiology of late life depression.

Journal Article J Am Geriatr Soc · September 1982 Full text Link to item Cite

Social support and mortality in an elderly community population.

Journal Article Am J Epidemiol · May 1982 A community sample made in the fall of 1972 in Durham County, North Carolina, and that consisted of 331 persons 65 years of age and older was assessed for adequacy of social support along three parameters: roles and available attachments, perceived social ... Full text Link to item Cite

Diagnosing organic mental disorders in the elderly.

Journal Article Am Fam Physician · May 1982 Link to item Cite

Using epidemiologic survey data to plan geriatric mental health services.

Journal Article Hosp Community Psychiatry · January 1982 A university medical center and a community mental health center undertook an epidemiologic survey of elderly residents of a county in North Carolina and used the data to plan a geriatric mental health program. The survey team assessed the rate and distrib ... Full text Link to item Cite

Chronic pain: a multiaxial approach to psychosocial assessment and intervention.

Journal Article South Med J · February 1981 With the advent of new and improved psychiatric treatment of chronic pain, increased interest has been directed toward psychosocial factors that contribute to chronic pain. Attention has been focused on assessing chronic pain and selecting therapy accordin ... Link to item Cite

Life events, mental health functioning and the use of health care services by the elderly.

Journal Article Am J Public Health · November 1980 The association of life events and mental health impairment was studied in a community-based population of the elderly (n = 986). A crude estimate of the relative risk for mental health impairment given life events larger than or equal to 150 (as measured ... Full text Link to item Cite

Older adults and their families in a community mental health center: strategies for intervention.

Journal Article Hosp Community Psychiatry · May 1980 Clinicians at a geriatric evaluation and treatment clinic include the patient's family in all stages of assessment and intervention so that the family can ultimately assume much of the responsibility for care. The family's strengths and weaknesses and its ... Full text Link to item Cite

Epidemiology of dysphoria and depression in an elderly population.

Journal Article Am J Psychiatry · April 1980 The authors surveyed 997 elderly people living in the community and found that the rate of significant dysphoric symptomatology was 14.7%. Forty-five (4.5%) of these individuals suffered from dysphoric symptoms only, and 37 (3.7%) had symptoms of a major d ... Full text Link to item Cite

The diagnosis of depression in the elderly.

Journal Article J Am Geriatr Soc · February 1980 The reported prevalence of depressive symptomatology among the elderly ranges from 5 to 65 percent in hospital and community populations. Depression is considered the most common emotional disorder of advanced age. One of the chief diagnostic problems has ... Full text Link to item Cite

Narcissism and the development of chronic pain.

Journal Article Int J Psychiatry Med · 1980 Thirteen patients were selected for study from a population of patients undergoing routine psychiatric evaluation in a Pain Clinic. These patients demonstrated consistent character traits (traits typically seen in the narcissistic personality) and appeared ... Full text Link to item Cite

Depression in late life.

Journal Article Am Fam Physician · November 1979 The depressed elderly have the highest suicide risk of any group in our society. Thus, depression in late life is a serious mental health problem. The essential goal of the diagnostic work-up is to distinguish a major depressive episode from less severe dy ... Link to item Cite

Perception of poor health in the healthy older adult.

Journal Article J Am Geriatr Soc · July 1979 A survey of 977 community subjects aged 65 or older identified 719 of them as not impaired in physical health. Of these, 104 (14 percent) perceived their physical status to be poor, whereas 615 (86 percent) accurately perceived it to be unimpaired. There w ... Full text Link to item Cite

Techniques for communicating with your elderly patient.

Journal Article Geriatrics · November 1978 A physician can best treat elderly patients if he or she understands their unique problems and employs effective techniques of communication. Be aware how your patient's anxiety or your own view about the elderly can erect a barrier to communication. Your ... Link to item Cite

Working with the elderly patient's family.

Journal Article Geriatrics · February 1978 Link to item Cite

Anorexia nervosa: a combined therapeutic approach.

Journal Article South Med J · April 1977 Ten female patients with a diagnosis of anorexia nervosa were treated with a combination of behavior modification and psychotherapy and, when appropriate, psychotropic medication. All patients had favorable weight gain and improvement in adjustment during ... Full text Link to item Cite

Affective psychoses following renal transplant.

Journal Article Dis Nerv Syst · December 1976 Six patients who developed affective psychoses following renal transplantation ae reported. Each patient was treated, with careful management, with an appropriate somatic therapy (including phenothiazines, tricyclic antidepressants, electroconvulsive treat ... Link to item Cite

Religion and aging in a longitudinal panel.

Journal Article Gerontologist · February 1976 Full text Link to item Cite

Observations on pain and suffering.

Journal Article Psychosomatics · 1976 Full text Link to item Cite

Pentazocine psychosis: a case of persistent delusions.

Journal Article Dis Nerv Syst · July 1975 A case of psychosis secondary to pentazocine is presented. The patient demonstrated hallucinations, preceptual aberrations, a distorted body image and delusional thinking. The delusional ideation persisted for a period of three weeks. Such a case of persis ... Link to item Cite

RELIGION AND AGING - ANALYSIS OF A LONGITUDINAL PANEL

Conference GERONTOLOGIST · January 1, 1975 Link to item Cite

Determinants of Poor Self-Rated Health in Late Life.

Journal Article Am J Geriatr Psychiatry The authors examined the determinants of poor self-rated health by use of data from the Duke University site of the Established Populations for Epidemiologic Studies of the Elderly (EPESE). Study participants were community residents, 65 years of age or ol ... Full text Link to item Cite