Scholars@Duke
David Manfield Brizel

David Manfield Brizel

Leonard Prosnitz Distinguished Professor of Radiation Oncology
Radiation Oncology
david.brizel@duke.edu
Box 3085 Med Ctr, Durham, NC 27710
05135 Morris Bldg, Durham, NC 27710

Selected Publications

Clinical commissioning and introduction of an in-house artificial intelligence (AI) platform for automated head and neck intensity modulated radiation therapy (IMRT) treatment planning.

Conference J Appl Clin Med Phys · January 2025 BACKGROUND AND PURPOSE: To describe the clinical commissioning of an in-house artificial intelligence (AI) treatment planning platform for head-and-neck (HN) Intensity Modulated Radiation Therapy (IMRT). MATERIALS AND METHODS: The AI planning platform has ... Full text Link to item Cite

Long-term risk of carotid stenosis and cerebrovascular disease after radiation therapy for head and neck cancer.

Conference Cancer · January 1, 2025 BACKGROUND: Recipients of radiation therapy (RT) for head and neck cancer (HNC) are at significantly increased risk for carotid artery stenosis (CAS) and cerebrovascular disease (CVD). We sought to determine (1) cumulative incidences of CAS and CVD among H ... Full text Link to item Cite

Radiomics on spatial-temporal manifolds via Fokker-Planck dynamics.

Conference Med Phys · May 2024 BACKGROUND: Delta radiomics is a high-throughput computational technique used to describe quantitative changes in serial, time-series imaging by considering the relative change in radiomic features of images extracted at two distinct time points. Recent wo ... Full text Link to item Cite

Prognostic value of different discretization parameters in 18fluorodeoxyglucose positron emission tomography radiomics of oropharyngeal squamous cell carcinoma.

Journal Article J Med Imaging (Bellingham) · March 2024 PURPOSE: We aim to interrogate the role of positron emission tomography (PET) image discretization parameters on the prognostic value of radiomic features in patients with oropharyngeal cancer. APPROACH: A prospective clinical trial (NCT01908504) enrolled ... Full text Link to item Cite

Clinical outcomes of oropharyngeal squamous cell carcinoma stratified by human papillomavirus subtype: A systematic review and meta-analysis.

Journal Article Oral Oncol · January 2024 PURPOSE: We aim to determine if there is a survival difference between patients with oropharyngeal squamous cell carcinoma (OPSCC) associated with human papillomavirus (HPV) 16 versus HPV-non16 subtypes. PATIENT AND METHODS: Databases were queried for full ... Full text Link to item Cite

The Affordable Care Act and suicide incidence among adults with cancer.

Journal Article J Cancer Surviv · April 2023 BACKGROUND: Patients with cancer are at an increased suicide risk, and socioeconomic deprivation may further exacerbate that risk. The Affordable Care Act (ACA) expanded insurance coverage options for low-income individuals and mandated coverage of mental ... Full text Link to item Cite

Low contralateral neck recurrence risk with ipsilateral neck radiotherapy in N2b tonsillar squamous cell carcinoma.

Journal Article Oral Oncol · April 2023 OBJECTIVES: To characterize factors including nodal burden, pre-treatment imaging, and other patient factors which may influence the role of ipsilateral neck radiotherapy (IRT) in tonsillar squamous cell carcinoma (SCC) with multiple involved ipsilateral n ... Full text Link to item Cite

NCCN Guidelines® Insights: Head and Neck Cancers, Version 1.2022.

Journal Article J Natl Compr Canc Netw · March 2022 The NCCN Guidelines for Head and Neck Cancers address tumors arising in the oral cavity (including mucosal lip), pharynx, larynx, and paranasal sinuses. Occult primary cancer, salivary gland cancer, and mucosal melanoma (MM) are also addressed. The specifi ... Full text Link to item Cite

Post-Radiotherapy PET Image Outcome Prediction by Deep Learning Under Biological Model Guidance: A Feasibility Study of Oropharyngeal Cancer Application.

Journal Article Front Oncol · 2022 PURPOSE: To develop a method of biologically guided deep learning for post-radiation 18FDG-PET image outcome prediction based on pre-radiation images and radiotherapy dose information. METHODS: Based on the classic reaction-diffusion mechanism, a novel bio ... Full text Link to item Cite

Adjuvant Radiation Therapy for Clinical Stage III Melanoma in the Modern Therapeutic Era.

Journal Article Annals of surgical oncology · July 2021 BackgroundAdjuvant radiation therapy (RT) can decrease lymph node basin (LNB) recurrences in patients with clinically evident melanoma lymph node (LN) metastases following lymphadenectomy, but its role in the era of modern systemic therapies (ST), ... Full text Cite

Intrinsic radiomic expression patterns after 20 Gy demonstrate early metabolic response of oropharyngeal cancers.

Journal Article Med Phys · July 2021 PURPOSE: This study investigated the prognostic potential of intra-treatment PET radiomics data in patients undergoing definitive (chemo) radiation therapy for oropharyngeal cancer (OPC) on a prospective clinical trial. We hypothesized that the radiomic ex ... Full text Link to item Cite

Chemotherapy and radiotherapy in locally advanced head and neck cancer: an individual patient data network meta-analysis.

Journal Article Lancet Oncol · May 2021 BACKGROUND: Randomised, controlled trials and meta-analyses have shown the survival benefit of concomitant chemoradiotherapy or hyperfractionated radiotherapy in the treatment of locally advanced head and neck cancer. However, the relative efficacy of thes ... Full text Link to item Cite

Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma.

Journal Article Clin Cancer Res · March 1, 2021 PURPOSE: In this prospective trial, we sought to assess the feasibility of concurrent administration of ipilimumab and radiation as adjuvant, neoadjuvant, or definitive therapy in patients with regionally advanced melanoma. PATIENTS AND METHODS: Twenty-fou ... Full text Link to item Cite

Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group.

Journal Article Radiother Oncol · March 2021 BACKGROUND AND PURPOSE: The Meta-Analysis of Chemotherapy in squamous cell Head and Neck Cancer (MACH-NC) demonstrated that concomitant chemotherapy (CT) improved overall survival (OS) in patients without distant metastasis. We report the updated results. ... Full text Link to item Cite

Establishing ADC-Based Histogram and Texture Features for Early Treatment-Induced Changes in Head and Neck Squamous Cell Carcinoma.

Journal Article Front Oncol · 2021 The purpose of this study was to assess baseline variability in histogram and texture features derived from apparent diffusion coefficient (ADC) maps from diffusion-weighted MRI (DW-MRI) examinations and to identify early treatment-induced changes to these ... Full text Link to item Cite

Early 18F-FDG-PET Response During Radiation Therapy for HPV-Related Oropharyngeal Cancer May Predict Disease Recurrence.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2020 PURPOSE: Early indication of treatment outcome may guide therapeutic de-escalation strategies in patients with human papillomavirus (HPV)-related oropharyngeal cancer (OPC). This study investigated the relationships between tumor volume and 18F-fluorodeoxy ... Full text Open Access Link to item Cite

Development and Implementation of an Educational Simulation Workshop in Fiberoptic Laryngoscopy for Radiation Oncology Residents.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2020 PURPOSE: Fiberoptic laryngoscopy (FOL) is a critical tool for the diagnosis, staging, assessment of treatment response, and detection of recurrence for head and neck (H&N) malignancies. No standardized recommendations exist for procedural FOL education in ... Full text Link to item Cite

Practice recommendations for risk-adapted head and neck cancer radiotherapy during the COVID-19 pandemic: An ASTRO-ESTRO consensus statement.

Journal Article Radiother Oncol · October 2020 PURPOSE: Because of the unprecedented disruption of health care services caused by the COVID-19 pandemic, the American Society of Radiation Oncology (ASTRO) and the European Society for Radiotherapy and Oncology (ESTRO) identified an urgent need to issue p ... Full text Link to item Cite

Practice Recommendations for Risk-Adapted Head and Neck Cancer Radiation Therapy During the COVID-19 Pandemic: An ASTRO-ESTRO Consensus Statement.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2020 PURPOSE: Because of the unprecedented disruption of health care services caused by the COVID-19 pandemic, the American Society of Radiation Oncology (ASTRO) and the European Society for Radiotherapy and Oncology (ESTRO) identified an urgent need to issue p ... Full text Link to item Cite

Head and Neck Cancers, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · July 2020 Treatment is complex for patients with head and neck (H&N) cancers with specific site of disease, stage, and pathologic findings guiding treatment decision-making. Treatment planning for H&N cancers involves a multidisciplinary team of experts. This articl ... Full text Link to item Cite

Dose-Distribution-Driven PET Image-Based Outcome Prediction (DDD-PIOP): A Deep Learning Study for Oropharyngeal Cancer IMRT Application.

Journal Article Front Oncol · 2020 PURPOSE: To develop a deep learning-based AI agent, DDD-PIOP (Dose-Distribution-Driven PET Image Outcome Prediction), for predicting 18FDG-PET image outcomes of oropharyngeal cancer (OPC) in response to intensity-modulated radiation therapy (IMRT). METHODS ... Full text Open Access Link to item Cite

Treatment Outcomes in Anaplastic Thyroid Cancer.

Journal Article J Thyroid Res · 2019 BACKGROUND: Anaplastic thyroid cancer (ATC) is rare, accounting for 1-2% of thyroid malignancies. Median survival is only 3-10 months, and the optimal therapeutic approach has not been established. This study aimed to evaluate outcomes in ATC based on trea ... Full text Link to item Cite

Adaptive IMRT Planning Improves Pharyngeal Sparing for Oropharyngeal Cancer

Conference International Journal of Radiation Oncology*Biology*Physics · November 2018 Full text Cite

The risk of carotid stenosis in head and neck cancer patients after radiation therapy.

Journal Article Oral Oncol · May 2018 OBJECTIVES: Head and neck radiotherapy (RT) is a risk factor for cerebrovascular disease. We performed a retrospective cohort study to evaluate carotid artery stenosis (CAS) incidence in head and neck cancer (HNC) patients undergoing RT, characterizing ass ... Full text Link to item Cite

NCCN Guidelines Insights: Head and Neck Cancers, Version 1.2018.

Journal Article J Natl Compr Canc Netw · May 2018 The NCCN Guidelines for Head and Neck (H&N) Cancers provide treatment recommendations for cancers of the lip, oral cavity, pharynx, larynx, ethmoid and maxillary sinuses, and salivary glands. Recommendations are also provided for occult primary of the H&N, ... Full text Link to item Cite

The Risk of Carotid Stenosis in Head and Neck Cancer Patients After Radiation Therapy

Conference International Journal of Radiation Oncology*Biology*Physics · April 2018 Full text Cite

The Incidence of Carotid Stenosis in Head and Neck Cancer Patients After Radiation Therapy

Conference International Journal of Radiation Oncology*Biology*Physics · October 2017 Full text Cite

NCCN Guidelines Insights: Head and Neck Cancers, Version 2.2017.

Journal Article J Natl Compr Canc Netw · June 2017 The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Head and Neck Cancers provide treatment recommendations for cancers of the lip, oral cavity, pharynx, larynx, ethmoid and maxillary sinuses, and salivary glands. Recommendations are al ... Full text Link to item Cite

Immunotherapy of head and neck cancer: Emerging clinical trials from a National Cancer Institute Head and Neck Cancer Steering Committee Planning Meeting.

Journal Article Cancer · April 1, 2017 Recent advances have permitted successful therapeutic targeting of the immune system in head and neck squamous cell carcinoma (HNSCC). These new immunotherapeutic targets and agents are being rapidly adopted by the oncologic community and hold considerable ... Full text Link to item Cite

Radiation therapy for oropharyngeal squamous cell carcinoma: Executive summary of an ASTRO Evidence-Based Clinical Practice Guideline.

Journal Article Pract Radiat Oncol · 2017 PURPOSE: To present evidence-based guidelines for the treatment of oropharyngeal squamous cell carcinoma (OPSCC) with definitive or adjuvant radiation therapy (RT). METHODS AND MATERIALS: The American Society for Radiation Oncology convened the OPSCC Guide ... Full text Link to item Cite

Pathology-based staging for HPV-positive squamous carcinoma of the oropharynx.

Journal Article Oral Oncol · November 2016 OBJECTIVE: The rapid worldwide rise in incidence of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) has generated studies confirming this disease as an entity distinct from traditional OPSCC. Based on pathology, surgical s ... Full text Link to item Cite

Prognostic value of midtreatment FDG-PET in oropharyngeal cancer.

Journal Article Head Neck · October 2016 BACKGROUND: Prognostic metabolic imaging indices are needed for risk stratification for patients with locally advanced oropharyngeal cancer. METHODS: We retrospectively examined pretreatment and midtreatment fluorodeoxyglucose-positron emission tomography ... Full text Link to item Cite

Oxygen and Perfusion Kinetics in Response to Fractionated Radiation Therapy in FaDu Head and Neck Cancer Xenografts Are Related to Treatment Outcome.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2016 PURPOSE: To test whether oxygenation kinetics correlate with the likelihood for local tumor control after fractionated radiation therapy. METHODS AND MATERIALS: We used diffuse reflectance spectroscopy to noninvasively measure tumor vascular oxygenation an ... Full text Link to item Cite

F-18-FDG PET/CT Response at 20 Gy Predicts Treatment Outcome for Head and Neck Squamous Cell Carcinoma (HNSCC)

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · October 1, 2016 Link to item Cite

Immunotherapy and Checkpoint Inhibitors in Recurrent and Metastatic Head and Neck Cancer.

Journal Article Am Soc Clin Oncol Educ Book · 2016 Immune surveillance is well recognized as an important mechanism to prevent development or progression of head and neck cancers. Head and neck cancer cells can escape the immune system through multiple mechanisms including development of tolerance in T cel ... Full text Link to item Cite

Translational research in head and neck oncology

Chapter · January 1, 2016 Translational research continues to shape the clinical practice of head and neck oncology. Ongoing discoveries in basic mechanisms of cancer biology and technological advances in diagnostic imaging and radiation delivery seek to improve treatment outcomes, ... Full text Cite

Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2015 PURPOSE: To test the effects of a novel Mn porphyrin oxidative stress modifier, Mn(III) meso-tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin (MnBuOE), for its radioprotective and radiosensitizing properties in normal tissue versus tumor, respectively. ME ... Full text Open Access Link to item Cite

Semiautomated head-and-neck IMRT planning using dose warping and scaling to robustly adapt plans in a knowledge database containing potentially suboptimal plans.

Journal Article Med Phys · August 2015 PURPOSE: Prior work by the authors and other groups has studied the creation of automated intensity modulated radiotherapy (IMRT) plans of equivalent quality to those in a patient database of manually created clinical plans; those database plans provided g ... Full text Link to item Cite

Head and Neck Cancers, Version 1.2015.

Journal Article J Natl Compr Canc Netw · July 2015 These NCCN Guidelines Insights focus on recent updates to the 2015 NCCN Guidelines for Head and Neck (H&N) Cancers. These Insights describe the different types of particle therapy that may be used to treat H&N cancers, in contrast to traditional radiation ... Full text Link to item Cite

Current status of clinical trials in head and neck cancer 2014.

Journal Article Otolaryngol Head Neck Surg · March 2015 INTRODUCTION: The last few years have seen significant increase in the number of available clinical trials in head and neck cancer. It has been difficult to stay abreast of these efforts because multiple cooperative groups and institutions are engaged in t ... Full text Link to item Cite

Diffusion-weighted imaging for head and neck squamous cell carcinoma: quantifying repeatability to understand early treatment-induced change.

Journal Article AJR Am J Roentgenol · November 2014 OBJECTIVE: The purpose of this study was to define baseline variability of apparent diffusion coefficient (ADC) on diffusion-weighted MR imaging (DWI) in patients with head and neck squamous cell carcinoma (HNSCC) and to compare it with early treatment-ind ... Full text Link to item Cite

Head and neck cancers, Version 2.2014. Clinical practice guidelines in oncology.

Journal Article J Natl Compr Canc Netw · October 2014 This selection from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Head and Neck Cancers focuses on glottic laryngeal cancer, which is the most common type of laryngeal cancer and has an excellent cure rate. The lymphatic drainage ... Full text Link to item Cite

Phase II multicenter trial of Caphosol for the reduction of mucositis in patients receiving radiation therapy for head and neck cancer.

Journal Article Oral Oncol · August 2014 PURPOSE: We conducted a phase II multicenter study evaluating Caphosol in patients receiving head and neck radiation (H/N RT) +/- chemotherapy or biologic sensitizer. MATERIALS/METHODS: The primary endpoint of the study tested the rate of functional mucosi ... Full text Link to item Cite

Comprehensive population-averaged arterial input function for dynamic contrast-enhanced vmagnetic resonance imaging of head and neck cancer.

Journal Article Int J Radiat Oncol Biol Phys · July 1, 2014 PURPOSE: To generate a population-averaged arterial input function (PA-AIF) for quantitative analysis of dynamic contrast-enhanced MRI data in head and neck cancer patients. METHODS AND MATERIALS: Twenty patients underwent dynamic contrast-enhanced MRI dur ... Full text Link to item Cite

Incidence and risk factors of significant carotid artery stenosis in asymptomatic survivors of head and neck cancer after radiotherapy.

Journal Article Head Neck · February 2014 BACKGROUND: The incidence and risk factors of carotid artery stenosis in asymptomatic patients after head and neck radiation therapy (RT) are unknown. METHODS: This retrospective study reviewed asymptomatic patients treated with RT for head and neck cancer ... Full text Link to item Cite

Adaptive Treatment Planning With F-18 FDG-PET and CT Scans to Optimize Parotid Sparing in Head-and-Neck Cancer

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Reduced Volume Irradiation for Head-and-Neck Cancer of Unknown Primary (HNCUP)

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Head and neck cancers, version 2.2013. Featured updates to the NCCN guidelines.

Journal Article J Natl Compr Canc Netw · August 2013 These NCCN Guidelines Insights focus on nutrition and supportive care for patients with head and neck cancers. This topic was a recent addition to the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Head and Neck Cancers. The NCCN Guide ... Full text Link to item Cite

Using FDG-PET to measure early treatment response in head and neck squamous cell carcinoma: quantifying intrinsic variability in order to understand treatment-induced change.

Journal Article AJNR Am J Neuroradiol · July 2013 BACKGROUND AND PURPOSE: Quantification of both baseline variability and intratreatment change is necessary to optimally incorporate functional imaging into adaptive therapy strategies for HNSCC. Our aim was to define the baseline variability of SUV on FDG- ... Full text Link to item Cite

Contemporary radiotherapy in head and neck cancer: balancing chance for cure with risk for complication.

Journal Article Surg Oncol Clin N Am · July 2013 Radiotherapy plays an integral role in the management of most patients with cancers of the head and neck. Better understanding of radiobiology and radiation physics has allowed radiation oncologists to enhance the tumoricidal effects of radiation and reduc ... Full text Link to item Cite

Radiation induces aerobic glycolysis through reactive oxygen species.

Journal Article Radiother Oncol · March 2013 BACKGROUND AND PURPOSE: Although radiation induced reoxygenation has been thought to increase radiosensitivity, we have shown that its associated oxidative stress can have radioprotective effects, including stabilization of the transcription factor hypoxia ... Full text Link to item Cite

SU‐E‐J‐200: Impact of FDG‐PET/CT Reconstruction Parameters On PET Variability and Treatment Response Assessment

Conference Medical Physics · January 1, 2013 Purpose: To examine the effect of PET image reconstruction parameters on baseline and early‐treatment FDG‐PET/CT quantitative imaging. Early‐treatment changes in tumor metabolism in primary tumor and nodes can potentially determine if the patient is respon ... Full text Cite

Transoral resection of pharyngeal cancer: summary of a National Cancer Institute Head and Neck Cancer Steering Committee Clinical Trials Planning Meeting, November 6-7, 2011, Arlington, Virginia.

Journal Article Head Neck · December 2012 Recent advances now permit resection of many pharyngeal tumors through the open mouth, an approach that can greatly reduce the morbidity of surgical exposure. These transoral techniques are being rapidly adopted by the surgical community and hold considera ... Full text Link to item Cite

Quantifying Temporal Fluctuations of DCE-MRI Extracted Parameters in Neck Nodal Metastases

Conference International Journal of Radiation Oncology*Biology*Physics · November 2012 Full text Cite

Predictive and prognostic role of functional imaging of head and neck squamous cell carcinomas.

Journal Article Semin Radiat Oncol · July 2012 Predicting radiotherapy (RT) treatment response and eventual locoregional disease control is an important component of the ongoing effort to improve the therapeutic ratio in the management of head and neck squamous cell carcinomas. The development of clini ... Full text Link to item Cite

SU-D-BRB-06: Comprehensive Population-Averaged Arterial Input Function (AIF) for DCE-MRI of Head and Neck Cancer.

Journal Article Med Phys · June 2012 PURPOSE: To generate a composite population-averaged(PA)-AIF for quantitative analysis of DCE-MRI data in head and neck (H&N) patients that is based on the right (RT) and left (LT) carotids, two pre-treatment scans, and one post-treatment scan. METHODS: Tw ... Full text Link to item Cite

Stereotactic radiotherapy for malignancies involving the trigeminal and facial nerves.

Journal Article Technol Cancer Res Treat · June 2012 Involvement of a cranial nerve caries a poor prognosis for many malignancies. Recurrent or residual disease in the trigeminal or facial nerve after primary therapy poses a challenge due to the location of the nerve in the skull base, the proximity to the b ... Full text Link to item Cite

Treatment-induced changes in vocal cord mobility and subsequent local recurrence after organ preservation therapy for laryngeal carcinoma.

Journal Article Head Neck · June 2012 BACKGROUND: As multidisciplinary cancer treatment evolves, strategies to identify patients needing early resection/salvage are necessary. Some have suggested that vocal cord function after organ-preservation treatment may be an indicator. METHODS: A retros ... Full text Link to item Cite

Development and clinical evaluation of a three-dimensional cone-beam computed tomography estimation method using a deformation field map.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2012 PURPOSE: To develop a three-dimensional (3D) cone-beam computed tomography (CBCT) estimation method using a deformation field map, and to evaluate and optimize the efficiency and accuracy of the method for use in the clinical setting. METHODS AND MATERIALS ... Full text Link to item Cite

Prospective trial of synchronous bevacizumab, erlotinib, and concurrent chemoradiation in locally advanced head and neck cancer.

Journal Article Clin Cancer Res · March 1, 2012 Featured Publication PURPOSE: We assessed the safety and efficacy of synchronous VEGF and epidermal growth factor receptor (EGFR) blockade with concurrent chemoradiation (CRT) in locally advanced head and neck cancer (HNC). EXPERIMENTAL DESIGN: Newly diagnosed patients with st ... Full text Link to item Cite

Mucosal melanoma of the head and neck.

Journal Article J Natl Compr Canc Netw · March 2012 Full text Link to item Cite

Dynamic contrast-enhanced MRI in head-and-neck cancer: the impact of region of interest selection on the intra- and interpatient variability of pharmacokinetic parameters.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2012 PURPOSE: Dynamic contrast-enhanced (DCE) MRI-extracted parameters measure tumor microvascular physiology and are usually calculated from an intratumor region of interest (ROI). Optimal ROI delineation is not established. The valid clinical use of DCE-MRI r ... Full text Link to item Cite

Analysis of pretreatment FDG-PET SUV parameters in head-and-neck cancer: tumor SUVmean has superior prognostic value.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2012 Featured Publication PURPOSE: To evaluate the prognostic significance of different descriptive parameters in head-and-neck cancer patients undergoing pretreatment [F-18] fluoro-D-glucose-positron emission tomography (FDG-PET) imaging. PATIENTS AND METHODS: Head-and-neck cancer ... Full text Link to item Cite

WE‐A‐217A‐02: The Impact of Fluorodeoxyglucose Positron Emission Tomography (FDG‐PET) Variability on the Assessment of Treatment Response in Head‐And‐Neck Cancer Patients Undergoing Chemoradiotherapy

Conference Medical Physics · January 1, 2012 Purpose: To compare intrinsic, temporal variability of tumor glucose metabolism versus early treatment‐induced change. This assessment is necessary to use changes in imaging parameters during therapy to properly segregate metabolic responders from non‐resp ... Full text Cite

FDG-PET assessment of the effect of head and neck radiotherapy on parotid gland glucose metabolism.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2012 Featured Publication PURPOSE: Functional imaging with [F-18]-fluorodeoxyglucose positron emission tomography (FDG-PET) provides the opportunity to define the physiology of the major salivary glands before and after radiation therapy. The goal of this retrospective study was to ... Full text Link to item Cite

Incidence of Asymptomatic Carotid Artery Stenosis in Survivors of Head and Neck Radiation

Conference International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

The Use of Serial FDG-PET Scanning to Develop Metabolic Response Criteria to Chemoradiation in Head and Neck Cancer (HNC)

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Effect of amifostine on survival among patients treated with radiotherapy: a meta-analysis of individual patient data.

Journal Article J Clin Oncol · June 20, 2011 PURPOSE: Controversy exists regarding whether or not amifostine might reduce the efficacy of cancer treatment. The aim of this meta-analysis was to evaluate the impact of amifostine on overall survival (OS) and progression-free survival (PFS) in patients t ... Full text Link to item Cite

Head and neck cancers.

Journal Article J Natl Compr Canc Netw · June 1, 2011 Full text Link to item Cite

Controversies in the locoregional management of head and neck cancer.

Journal Article J Natl Compr Canc Netw · June 1, 2011 Featured Publication Head and neck cancer (HNC) is a heterogeneous combination of various sites and types of disease. This manuscript elaborates on 3 important and current issues: the emerging role of human papilloma virus (HPV) in oropharyngeal cancer (OPC), current considera ... Full text Link to item Cite

Head and neck cancer as a model for advances in imaging prognosis, early assessment, and posttherapy evaluation.

Journal Article Cancer J · 2011 Featured Publication Novel noninvasive functional imaging methods are necessary to predict therapeutic outcome and thereby improve the ability to properly select patients for treatment with both conventional and targeted therapies, to better evaluate therapeutic effectiveness ... Full text Link to item Cite

The role of adaptive and functional imaging modalities in radiation therapy: approach and application from a radiation oncology perspective.

Journal Article Semin Ultrasound CT MR · December 2010 The field of radiation oncology relies heavily on imaging modalities. From initial consultation to treatment completion, images are used to guide nearly every step of the patient encounter. Technological advances in diagnostic radiology continue to be read ... Full text Link to item Cite

Dynamic contrast enhanced-MRI in head and neck cancer patients: Variability of the precontrast longitudinal relaxation time (T10).

Journal Article Med Phys · June 2010 PURPOSE: Calculation of the precontrast longitudinal relaxation times (T10) is an integral part of the Tofts-based pharmacokinetic (PK) analysis of dynamic contrast enhanced-magnetic resonance images. The purpose of this study was to investigate the interp ... Full text Link to item Cite

SU‐GG‐T‐136: Treatment Plans Comparison with Static‐Gantry IMRT and RapidArcTM for Head‐And‐Neck Cancers Involving Cervical Lymph Nodes

Conference Medical Physics · January 1, 2010 Purpose: To compare the dosimetric results and treatment efficiency of intensity modulated arc therapy using RapidArc™ to static‐gantry IMRT plans for conventional fractionation treatment of head‐and‐neck cancer. Materials and Methods: This study evaluated ... Full text Cite

Clinical practice guidance for radiotherapy planning after induction chemotherapy in locoregionally advanced head-and-neck cancer.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2009 PURPOSE: The use of induction chemotherapy (IC) for locoregionally advanced head-and-neck cancer is increasing. The response to IC often causes significant alterations in tumor volume and location and shifts in normal anatomy. Proper determination of the r ... Full text Link to item Cite

Prognostic Value of Pre- and Post-treatment FDG PET in Head-and-Neck Cancer

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Synchronous Chemoradiation and Multiple Targeted Drugs for Advanced Head and Neck Cancer

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Mucositis-related morbidity and resource utilization in head and neck cancer patients receiving radiation therapy with or without chemotherapy.

Journal Article J Pain Symptom Manage · October 2009 Featured Publication The objective of this study was to estimate health care-resource utilization in head and neck cancer (HNC) patients. This was a prospective, longitudinal, multicenter, noninterventional study of mucositis in patients receiving radiation with or without che ... Full text Link to item Cite

Paraganglioma of the head and neck: long-term local control with radiotherapy.

Journal Article Am J Clin Oncol · June 2009 OBJECTIVES: Paragangliomas are rare neuroendocrine neoplasms of the head and neck. Treatment strategies include resection, definitive external beam radiation therapy (EBRT), stereotactic radiosurgery (SRS), or observation alone. Due to their rarity and ind ... Full text Link to item Cite

Targeting the future in head and neck cancer.

Journal Article Lancet Oncol · March 2009 Featured Publication Full text Link to item Cite

SU‐FF‐T‐130: Radiotherapy Treatment Plans with RapidArc for Head‐And‐Neck Cancer

Conference Medical Physics · January 1, 2009 Purpose: The purpose of this study is to compare RapidArc plans and conventional IMRT plans for head‐and‐neck cancer treatment involving bilateral nodes. Methods and Materials: This study included 10 locally advanced head‐and‐neck cancer patients. The plan ... Full text Cite

Head and neck cancer. Introduction.

Journal Article Semin Radiat Oncol · January 2009 Full text Link to item Cite

Induction chemotherapy: to use or not to use? That is the question.

Journal Article Semin Radiat Oncol · January 2009 Featured Publication The intensification of radiation, induction chemotherapy, and concomitant chemoradiotherapy has been extensively investigated over the past 2 decades for the nonsurgical management of locally advanced, nonmetastatic squamous cell head and neck cancer (HNC) ... Full text Link to item Cite

Head and neck cancers.

Journal Article J Natl Compr Canc Netw · August 2008 Full text Link to item Cite

Phase II study of palifermin and concurrent chemoradiation in head and neck squamous cell carcinoma.

Journal Article J Clin Oncol · May 20, 2008 Featured Publication PURPOSE: Acute mucositis is a dose-limiting toxicity of concurrent chemoradiotherapy regimens for locally advanced head and neck cancer. Palifermin (a recombinant human keratinocyte growth factor; DeltaN23-KGF) stimulates the proliferation and differentiat ... Full text Link to item Cite

Preoperative radiotherapy and bevacizumab for angiosarcoma of the head and neck: two case studies.

Journal Article Head Neck · February 2008 BACKGROUND: Angiosarcoma of the face is a vascular tumor with poor local control and short median survival despite standard treatment. Bevacizumab is a humanized monoclonal antibody to vascular endothelial growth factor (VEGF), which can inhibit tumor grow ... Full text Link to item Cite

SU‐GG‐J‐181: The Role of Voxel‐Based T10 Calculations in Determining Correct Pharmacokinetic Parameters for Head and Neck Tumors

Conference Medical Physics · January 1, 2008 Purpose: To determine the optimal flip angle combination (oFAc) that generates voxel‐based T10 values, the median T10 for primary and nodes [formula omitted], and its implications on vascular permeability (PERM) and extracellular volume fraction (EVF) in H ... Full text Cite

NCCN Task Force Report. prevention and management of mucositis in cancer care.

Journal Article J Natl Compr Canc Netw · January 2008 Oral mucositis (OM) has emerged as a common cause of dose delays and interruptions of cancer therapies such as multicycle chemotherapy, myeloablative chemotherapy, and radiotherapy with or without concurrent chemotherapy of head and neck cancer. Research i ... Link to item Cite

Radioprotective effects of amifostine on acute and chronic esophageal injury in rodents.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2007 Featured Publication PURPOSE: This study was performed to evaluate the protective benefit of amifostine against esophageal injury from fractionated radiation in a rodent model. METHODS: Fractionated or sham esophageal irradiation was administered to Fisher-344 rats for 5 conse ... Full text Link to item Cite

On-board patient positioning for head-and-neck IMRT: comparing digital tomosynthesis to kilovoltage radiography and cone-beam computed tomography.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2007 PURPOSE: High-precision intensity-modulated radiotherapy demands high patient positioning accuracy. On-board digital tomosynthesis (DTS) provides three-dimensional (3D) image guidance for daily positioning with a lower imaging dose, faster acquisition, and ... Full text Link to item Cite

Pharmacologic approaches to radiation protection.

Journal Article J Clin Oncol · September 10, 2007 Featured Publication The concept of the therapeutic ratio (TR) is central to understanding the rationale for using radioprotectors. The TR relates tumor control probabilities and normal tissue complication probabilities to one another. An ideal radioprotector will reduce the l ... Full text Link to item Cite

Concomitant chemoradiotherapy

Journal Article Journal of Clinical Oncology · September 10, 2007 Full text Cite

How much radiation is the chemotherapy worth in advanced head and neck cancer?

Journal Article Int J Radiat Oncol Biol Phys · August 1, 2007 Featured Publication PURPOSE: To estimate the radiotherapeutic dose equivalence of chemoradiotherapy in head and neck cancer. METHODS: The biologic equivalent dose (BED) of radiotherapy in nine trials of standard and five trials of modified fractionated radiotherapy with or wi ... Full text Link to item Cite

The potential role of intrinsic hypoxia markers as prognostic variables in cancer.

Journal Article Antioxid Redox Signal · August 2007 Tumor hypoxia is related to tumor progression and therapy resistance, which leads to poor patient outcome. It has been suggested that measuring the hypoxic status of a tumor helps to predict patient outcome and to select more targeted treatment. However, c ... Full text Link to item Cite

Longitudinal evaluation of the oral mucositis weekly questionnaire-head and neck cancer, a patient-reported outcomes questionnaire.

Journal Article Cancer · May 1, 2007 BACKGROUND: Quality-of-life instruments that measure specific functional consequences of mucositis are needed to assess the efficacy of therapeutic interventions targeted against mucositis and to guide patient care. The authors undertook a prospective, mul ... Full text Link to item Cite

A Phase II trial of subcutaneous amifostine and radiation therapy in patients with head-and-neck cancer.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2007 PURPOSE: Intravenous amifostine 200 mg/m2 reduces xerostomia in head-and-neck cancer patients. This Phase II study evaluated subcutaneous (s.c.) amifostine in a similar patient population. PATIENTS AND METHODS: Patients received amifostine 500 mg, administ ... Full text Link to item Cite

Multiple etiologies of tumor hypoxia require multifaceted solutions.

Journal Article Clin Cancer Res · January 15, 2007 Featured Publication Full text Link to item Cite

TH‐E‐M100J‐02: Potential of Dynamic Contrast Enhanced‐Magnetic Resonance Imaging (DCE‐MRI) Extracted Parameters to Estimate Treatment Response in Locally Advanced Head and Neck (LAHN) Cancer Patients

Conference Medical Physics · January 1, 2007 Purpose: To evaluate the use of DCE‐MRI to measure changes in tumor physiology in LAHN cancer patients receiving TT and cisplatin based concurrent chemoradiation (ChemoRT). Material and Methods: Eligible patients with LAHN were enrolled on an IRB approved ... Full text Cite

1025

Conference International Journal of Radiation Oncology*Biology*Physics · November 2006 Full text Cite

117

Conference International Journal of Radiation Oncology*Biology*Physics · November 2006 Full text Cite

Oral mucositis (OM) related morbidity and resource utilization in a prospective study of head and neck cancer (HNC) patients.

Journal Article J Clin Oncol · June 20, 2006 5539 Background: Few studies have reported the burden of oropharyngeal mucositis (OM) as well as the downstream resource consumption and risk of complications due to OM following standard therapy in head and neck cancer patients. This study was a prospecti ... Link to item Cite

Concurrent chemoradiotherapy for locally advanced, nonmetastatic, squamous carcinoma of the head and neck: consensus, controversy, and conundrum.

Journal Article J Clin Oncol · June 10, 2006 Featured Publication Radiotherapy and concurrent chemotherapy (CRT) is superior to radiotherapy alone for the treatment of locally advanced, nonmetastatic squamous carcinoma of the head and neck (HNC). Three issues affect the use of CRT as primary treatment for advanced HNC. T ... Full text Link to item Cite

38 Clinical status of keratinocyte growth factor

Conference Radiotherapy and Oncology · March 2006 Full text Cite

Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor.

Journal Article Cancer Res · February 15, 2006 To test the hypothesis that temporal variations in microvessel red cell flux cause unstable oxygen levels in tumor interstitium, extravascular oxygenation of R3230Ac mammary tumors grown in skin-fold window chambers was measured using recessed tip polarogr ... Full text Link to item Cite

The effect of darbepoetin alfa on growth, oxygenation and radioresponsiveness of a breast adenocarcinoma.

Journal Article Radiat Res · February 2006 Tumor hypoxia is associated with poor clinical outcome in a variety of tumors, including cervical, head/neck and breast cancer. Administration of erythropoietic factors has been suggested as a means of improving tumor oxygenation (pO2). This study randomiz ... Full text Link to item Cite

SU‐FF‐J‐125: Therapy Assessment Using a Full Time Point (fTP) Pharmacokinetic Analysis of Dynamic Contrast‐Enhanced Magnetic Resonance Imaging (DCE‐MRI): Role of Region of Interest (ROI) Selection in Three Tumor Sites

Conference Medical Physics · January 1, 2006 Background: DCE‐MRI has great potential to provide routine assessment of cancer treatment response. The contrast agent preferentially accumulates in tumors due to increased tumor vascular permeability. The MR based parameters that can be used for treatment ... Full text Cite

Influence of intravenous amifostine on xerostomia, tumor control, and survival after radiotherapy for head-and- neck cancer: 2-year follow-up of a prospective, randomized, phase III trial.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2005 PURPOSE: To evaluate chronic xerostomia and tumor control 18 and 24 months after initial treatment with amifostine in a randomized controlled trial of patients with head-and-neck cancer; at 12 months after radiotherapy (RT), amifostine had been shown to re ... Full text Link to item Cite

Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study.

Journal Article Radiother Oncol · October 2005 PURPOSE: To analyze the relationship between pre-treatment measurements of tumor oxygen tension (pO2) and survival in advanced head and neck cancer. PATIENTS AND METHODS: Eppendorf pO2 measurements in 397 patients from seven centers were analyzed using the ... Full text Link to item Cite

Amifostine for Xerostomia - Normal Tissue Protection at What Cost?

Conference International Journal of Radiation Oncology*Biology*Physics · October 2005 Full text Cite

Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2005 The ability to optimize treatments for cancer on the basis of relative risks for normal tissue injury has important implications in oncology, because higher doses of radiation might, in some diseases, improve both local control and survival. To achieve thi ... Full text Link to item Cite

Head and neck cancers.

Journal Article J Natl Compr Canc Netw · May 2005 Full text Link to item Cite

Pretreatment anemia is correlated with the reduced effectiveness of radiation and concurrent chemotherapy in advanced head and neck cancer.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2005 Featured Publication PURPOSE: Pretreatment anemia is an adverse prognostic variable in squamous cell head-and-neck cancer (HNC) patients treated with radiotherapy (RT) alone. Tumor hypoxia is an adverse parameter for treatment with RT alone or with RT and concurrent chemothera ... Full text Link to item Cite

Relation between pO2, 31P magnetic resonance spectroscopy parameters and treatment outcome in patients with high-grade soft tissue sarcomas treated with thermoradiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2005 PURPOSE: In a prior study, the combination of (31)P magnetic resonance spectroscopy (MRS)-based intracellular pH (pHi) and T2 relaxation time was highly predictive of the pathologic complete response (pCR) rate in a small series of patients with soft tissu ... Full text Link to item Cite

The protective effect of recombinant human keratinocyte growth factor on radiation-induced pulmonary toxicity in rats.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2004 Featured Publication PURPOSE: Radiation-induced lung toxicity is a significant dose-limiting side effect of radiotherapy for thoracic tumors. Recombinant human keratinocyte growth factor (rHuKGF) has been shown to be a mitogen for type II pneumocytes. The purpose of this study ... Full text Link to item Cite

Tumor-dependent kinetics of partial pressure of oxygen fluctuations during air and oxygen breathing.

Journal Article Cancer Res · September 1, 2004 The primary purpose of this study was to examine the kinetics of partial pressure of oxygen (pO2) fluctuations in fibrosarcoma (FSA) and 9L tumors under air and O2 breathing conditions. The overall hypothesis was that key factors relating to oxygen tension ... Full text Link to item Cite

Assessment and management of cutaneous reactions with amifostine administration: findings of the ethyol (amifostine) cutaneous treatment advisory panel (ECTAP).

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2004 PURPOSE: To review reports of severe skin reactions during amifostine treatment. METHODS AND MATERIAL: The expert panel reviewed postmarketing reports of skin reactions and discussed strategies for evaluation and management. RESULTS: Between 1994 and April ... Full text Link to item Cite

Thermochemoradiotherapy improves oxygenation in locally advanced breast cancer

Journal Article Women's Oncology Review · September 1, 2004 Full text Cite

The influence of intravenous amifostine on xerostomia and survival during radiotherapy for head and neck cancer: Two year follow-up of a prospective randomized trial.

Journal Article J Clin Oncol · July 15, 2004 5536 Background: Amifostine (A, Ethyol) reduced radiotherapy (RT)-induced xerostomia without diminishing tumor control at 12 months in a prospective, randomized trial of patients receiving head and neck RT (Brizel et al, J Clin Oncol 2000;18:3339-45). The ... Link to item Cite

Thermochemoradiotherapy improves oxygenation in locally advanced breast cancer.

Journal Article Clin Cancer Res · July 1, 2004 PURPOSE: The purpose of this research was to evaluate toxicity, response, and changes in oxygenation (pO(2)) in patients with locally advanced breast cancer (LABC) treated with concurrent taxol, hyperthermia (HT), and radiation therapy (RT) followed by mas ... Full text Link to item Cite

Necessity for adjuvant neck dissection in setting of concurrent chemoradiation for advanced head-and-neck cancer.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2004 Featured Publication PURPOSE: Neck dissection has traditionally played an important role in the treatment of patients with squamous cell carcinoma of the head and neck who present with regionally advanced neck disease (N2-N3). Radiotherapy and concurrent chemotherapy improves ... Full text Link to item Cite

Human recombinant erythropoietin significantly improves tumor oxygenation independent of its effects on hemoglobin.

Journal Article Cancer Res · October 1, 2003 Tumor oxygenation is known to be an important predictive/prognostic marker in a variety of tumors, including cervix, head/neck, sarcoma, non-small cell of the lung, and breast. Tumor oxygenation is influenced by many interactions, including oxygen delivery ... Link to item Cite

Effect of longitudinal oxygen gradients on effectiveness of manipulation of tumor oxygenation.

Journal Article Cancer Res · August 1, 2003 The purpose of this study was to test the hypothesis that longitudinal O(2) gradients in tumor affect response to manipulation of oxygenation. Previously we showed that pO(2) is higher on the fascial than the tumor surface of the R3230Ac rat mammary carcin ... Link to item Cite

The prevention and treatment of radiotherapy - induced xerostomia.

Journal Article Semin Radiat Oncol · July 2003 Efforts to reduce the severity of postradiotherapy xerostomia include the use of salivary substitutes to gain symptomatic relief, salivary gland stimulants, agents delivered to protect the glands during radiotherapy (RT), and physical means to partially sp ... Full text Link to item Cite

How should we measure and report radiotherapy-induced xerostomia?

Journal Article Semin Radiat Oncol · July 2003 Xerostomia is commonly measured and graded using objective measures of major salivary gland output and observer-rated toxicity grading. The separation between the different grades is somewhat ambiguous in the current toxicity grading systems. We propose a ... Full text Link to item Cite

Does amifostine have a role in chemoradiation treatment?

Journal Article Lancet Oncol · June 2003 Featured Publication For many years, scientists have been investigating use of drugs to protect normal tissue from injury during radiation therapy, thereby increasing the amount of radiation that can be safely administered to patients. Despite the introduction of modern shield ... Full text Link to item Cite

A mathematical model of tumor oxygen and glucose mass transport and metabolism with complex reaction kinetics.

Journal Article Radiat Res · March 2003 Hypoxia imparts radioresistance to tumors, and various approaches have been developed to enhance oxygenation, thereby improving radiosensitivity. This study explores the influence of kinetic and physical factors on substrate metabolism in a tumor model, ba ... Full text Link to item Cite

M6P/IGF2R loss of heterozygosity in head and neck cancer associated with poor patient prognosis.

Journal Article BMC Cancer · February 13, 2003 BACKGROUND: The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) encodes for a multifunctional receptor involved in lysosomal enzyme trafficking, fetal organogenesis, cytotoxic T cell-induced apoptosis and tumor suppression. The purpos ... Full text Link to item Cite

M6P/IGF2R loss of heterozygosity in head and neck cancer associated with poor patient prognosis

Journal Article BMC Cancer · February 13, 2003 Background: The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) encodes for a multifunctional receptor involved in lysosomal enzyme trafficking, fetal organogenesis, cytotoxic T cell-induced apoptosis and tumor suppression. The purpos ... Full text Cite

Ultrasound guided pO2 measurement of breast cancer reoxygenation after neoadjuvant chemotherapy and hyperthermia treatment.

Journal Article Int J Hyperthermia · 2003 The objective of this study was to determine whether neoadjuvant chemotherapy in combination with hyperthermia (HT) would improve oxygenation in locally advanced breast tumours. The study describes a new optimized ultrasound guided technique of pO2 measure ... Full text Link to item Cite

Radioprotection of lungs by amifostine is associated with reduction in profibrogenic cytokine activity.

Journal Article Radiat Res · June 2002 Radiation-induced pulmonary toxicity causes significant morbidity and mortality in patients irradiated for lung cancer, breast cancer, lymphoma or thymoma. Amifostine is an important drug in the emerging field of cytoprotection. Recent advances in our unde ... Full text Link to item Cite

Assessment of the protective effect of amifostine on radiation-induced pulmonary toxicity.

Journal Article Exp Lung Res · 2002 Featured Publication The objective of this study was to assess the radioprotective effects of amifostine in the rat model of radiation-induced lung injury using fractionated doses of radiation, to determine whether amifostine given before irradiation protects tumor from radiat ... Full text Link to item Cite

Head and neck: Editorial

Journal Article Head and Neck · December 13, 2001 Full text Cite

Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2001 PURPOSE: It has been shown that oxygen gradients exist in R3230AC tumors grown in window chambers. The fascial surface is better oxygenated than the tumor surface. The purpose of the present study was to determine whether gradients exist for energy metabol ... Full text Link to item Cite

The role of amifostine as a radioprotector.

Journal Article Oncology (Williston Park) · October 2001 Effective radiotherapy for patients with cancer should include maximal tumor cell killing with minimal injury to normal tissue. Radiation doses that can be delivered, without causing severe damage to surrounding normal tissues, can be insufficient to eradi ... Link to item Cite

Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2001 Featured Publication PURPOSE: Hypoxia shifts the balance of cellular energy production toward glycolysis with lactate generation as a by-product. Quantitative bioluminescence imaging allows for the quantitation of lactate concentrations in individual tumors. We assessed the re ... Full text Link to item Cite

Simultaneous administration of glucose and hyperoxic gas achieves greater improvement in tumor oxygenation than hyperoxic gas alone.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2001 PURPOSE: To test the feasibility of hyperglycemic reduction of oxygen consumption combined with oxygen breathing (O(2)), to improve tumor oxygenation. METHODS AND MATERIALS: Fischer-344 rats bearing 1 cm R3230Ac flank tumors were anesthetized with Nembutal ... Full text Link to item Cite

A phase II trial testing the thermal dose parameter CEM43 degrees T90 as a predictor of response in soft tissue sarcomas treated with pre-operative thermoradiotherapy.

Journal Article Int J Hyperthermia · 2001 We prospectively evaluated whether delivering a thermal dose of > 10 cumulative equivalent minutes at 43 degrees C to >90% of the tumour sites monitored (CEM43 degrees T90) would produce a pathologic complete response (pCR) in > 75% of high-grade soft tiss ... Full text Link to item Cite

Effect of amifostine on patient assessed clinical benefit in irradiated head and neck cancer.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2000 Featured Publication PURPOSE: To determine if head and neck (H/N) cancer patients receiving daily amifostine during radiation therapy (RT) experienced clinical benefit (improvement in their ability to carry out normal functions with reduced discomfort) compared to nonamifostin ... Full text Link to item Cite

Review of methods used to study oxygen transport at the microcirculatory level.

Journal Article Int J Cancer · October 20, 2000 The existence of hypoxic regions in tumors has long been recognized as a key factor leading to radiation resistance. More recently, it has been found that low oxygen levels also affect drug resistance, angiogenesis, cytokine production, cell cycle control, ... Link to item Cite

Phase III randomized trial of amifostine as a radioprotector in head and neck cancer.

Journal Article J Clin Oncol · October 1, 2000 Featured Publication PURPOSE: Radiotherapy for head and neck cancer causes acute and chronic xerostomia and acute mucositis. Amifositine and its active metabolite, WR-1065, accumulate with high concentrations in the salivary glands. This randomized trial evaluated whether amif ... Full text Link to item Cite

Temperature-dependent changes in physiologic parameters of spontaneous canine soft tissue sarcomas after combined radiotherapy and hyperthermia treatment.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2000 PURPOSE: The objectives of this study were to evaluate effects of hyperthermia on tumor oxygenation, extracellular pH (pHe), and blood flow in 13 dogs with spontaneous soft tissue sarcomas prior to and after local hyperthermia. METHODS AND MATERIALS: Tumor ... Full text Link to item Cite

Double blind randomized trial of sucralfate vs placebo during radical radiotherapy for head and neck cancers.

Journal Article Head Neck · December 1999 Featured Publication BACKGROUND: This study sought to determine whether sucralfate prophylaxis during a course of high dose radiation therapy (RT) for head and neck cancer decreases acute side effects. METHODS: Patients receiving curative intent RT for advanced head and neck c ... Full text Link to item Cite

The treatment of high-grade soft tissue sarcomas with preoperative thermoradiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 1999 PURPOSE: To explore the use of a novel program of preoperative radiation and hyperthermia in the management of high-grade soft tissue sarcomas (STS). METHODS AND MATERIALS: Eligible patients were adults over 18 with Grade 2 or 3 STS, surgically resectable ... Full text Link to item Cite

Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome.

Journal Article Radiother Oncol · November 1999 Featured Publication BACKGROUND AND PURPOSE: To evaluate the long term clinical significance of tumor oxygenation in a population of head and neck cancer patients receiving radiotherapy and to assess changes in tumor oxygenation during the course of treatment. METHODS AND MATE ... Full text Link to item Cite

Conformal radiation therapy treatment planning reduces the dose to the optic structures for patients with tumors of the paranasal sinuses.

Journal Article Radiother Oncol · June 1999 PURPOSE: Compare dose distributions of traditional versus conformal beam orientations in paranasal sinus malignancies. MATERIALS AND METHODS: Maximum normal tissue doses, dose volume histograms (DVH), normal tissue complication probabilities (NTCP), and th ... Full text Link to item Cite

Future directions in toxicity prevention

Journal Article Seminars in Radiation Oncology · November 5, 1998 The modern practice of radiation therapy has developed over several decades, taking into consideration the anatomic location of the tumor, technical aspects of radiation delivery, combined treatment modalities, and patient comorbidity. Improved understandi ... Cite

Treatment of head and neck cancer.

Journal Article N Engl J Med · October 29, 1998 Full text Link to item Cite

Treatment of head and neck cancer - Reply

Journal Article NEW ENGLAND JOURNAL OF MEDICINE · October 29, 1998 Link to item Cite

Radiotherapy and concurrent chemotherapy for the treatment of locally advanced head and neck squamous cell carcinoma.

Journal Article Semin Radiat Oncol · October 1998 Cure of locally advanced squamous cell carcinoma of the head and neck (SCCHN) is uncommon with radiotherapy alone. The desire for organ preservation in advanced resectable SCCHN and the need for better local therapy for unresectable disease have led to the ... Full text Link to item Cite

Future directions in toxicity prevention.

Journal Article Semin Radiat Oncol · October 1998 The modern practice of radiation therapy has developed over several decades, taking into consideration the anatomic location of the tumor, technical aspects of radiation delivery, combined treatment modalities, and patient comorbidity. Improved understandi ... Link to item Cite

Future directions in toxicity prevention.

Conference Seminars in radiation oncology · October 1998 The modern practice of radiation therapy has developed over several decades, taking into consideration the anatomic location of the tumor, technical aspects of radiation delivery, combined treatment modalities, and patient comorbidity. Improved understandi ... Cite

Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer.

Journal Article N Engl J Med · June 18, 1998 Featured Publication BACKGROUND: Radiotherapy is often the primary treatment for advanced head and neck cancer, but the rates of locoregional recurrence are high and survival is poor. We investigated whether hyperfractionated irradiation plus concurrent chemotherapy (combined ... Full text Link to item Cite

Artificial neural network model of survival in patients treated with irradiation with and without concurrent chemotherapy for advanced carcinoma of the head and neck.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 1998 PURPOSE: This study was performed to investigate the feasibility of predicting survival in squamous cell carcinoma of the head and neck (SCCHN) with an artificial neural network (ANN), and to compare ANN performance with conventional models. METHODS AND MA ... Full text Link to item Cite

Where there's smoke, is there fire?

Journal Article Int J Hyperthermia · 1998 Full text Link to item Cite

Radiation techniques for the treatment of Hodgkin's disease with combined modality therapy or radiation alone.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 1997 Featured Publication This article reviews radiation techniques including field arrangements, anatomic borders, and doses for the treatment of Hodgkin's disease when radiotherapy is being used as the sole treatment and when it is part of a planned combined modality program with ... Full text Link to item Cite

Response to the Letter of Drs. Hartmann et al.

Journal Article Radiation Research · November 1997 Full text Cite

Interlaboratory variation in oxygen tension measurement by Eppendorf "Histograph" and comparison with hypoxic marker.

Journal Article J Surg Oncol · September 1997 BACKGROUND AND OBJECTIVES: The median of pO2 values in tumor measured by Eppendorf "Histograph" with a needle-type electrode has been used as a prognostic indicator in cancer patients. However, it is not established that a pretreatment measured pO2 value c ... Full text Link to item Cite

Comparison of two head and neck immobilization systems.

Journal Article Int J Radiat Oncol Biol Phys · July 1, 1997 PURPOSE: Accurate and reproducible patient positioning is fundamental to the success of fractionated radiotherapy. Concurrent with the introduction of three-dimensional treatment planning capabilities at our institution, a head and neck immobilization syst ... Full text Link to item Cite

Hyperbaric oxygen improves tumor radiation response significantly more than carbogen/nicotinamide.

Journal Article Radiat Res · June 1997 Featured Publication This laboratory previously demonstrated that hyperbaric oxygen and hyperbaric carbogen improved oxygenation in the R3230Ac tumor, but normobaric 100% O2 and carbogen did not. The current study assessed tumor growth after exposure to radiation plus either h ... Link to item Cite

Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 1997 Featured Publication PURPOSE: Tumor hypoxia adversely affects short term clinical radiation response of head and neck cancer lymph node metastases and long term disease-free survival (DFS) in cervix carcinoma. This study was performed to evaluate the relationship between tumor ... Full text Link to item Cite

2013 The impact of hypoxia and oxygenation modification on the radiation response of an intracranial rat glioma

Journal Article International Journal of Radiation Oncology*Biology*Physics · January 1997 Full text Cite

Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas.

Journal Article Cancer Res · December 1, 1996 Featured Publication The adverse prognostic impact of tumor hypoxia has been demonstrated in human malignancy. We report the effects of radiotherapy and hyperthermia (HT) on soft tissue sarcoma oxygenation and the relationship between treatment-induced changes in oxygenation a ... Link to item Cite

Monitoring of neoadjuvant therapy response of soft-tissue and musculoskeletal sarcoma using fluorine-18-FDG PET.

Journal Article J Nucl Med · September 1996 UNLABELLED: The purpose of this study was to investigate the potential role of FDG-PET in the monitoring of neoadjuvant therapy of soft-tissue and musculoskeletal sarcomas. METHODS: Nine patients were studied. Neoadjuvant therapy consisted of either chemot ... Link to item Cite

Arteriolar oxygenation in tumour and subcutaneous arterioles: effects of inspired air oxygen content.

Journal Article Br J Cancer Suppl · July 1996 Carbogen is thought to be more effective than normobaric oxygen in reducing tumour hypoxia because it may reduce hyperoxic vasoconstriction. In this study, tumour and normal arteriolar diameters were measured simultaneously with perivascular pO2 during air ... Link to item Cite

Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.

Journal Article Cancer Res · March 1, 1996 Featured Publication This study was performed to explore the relationship between tumor oxygenation and treatment outcome in human soft tissue sarcoma. Twenty-two patients with nonmestastatic, high-grade, soft tissue sarcomas underwent preoperative irradiation and hyperthermia ... Link to item Cite

Arteriolar oxygenation in tumour and subcutaneous arterioles: Effects of inspired air oxygen content

Journal Article British Journal of Cancer · January 1, 1996 Carbogen is thought to be more effective than normobaric oxygen in reducing tumour hypoxia because it may reduce hyperoxic vasoconstriction. In this study, tumour and normal arteriolar diameters were measured simultaneously with perivascular pO2 during air ... Cite

The mechanisms by which hyperbaric oxygen and carbogen improve tumour oxygenation.

Journal Article Br J Cancer · November 1995 Featured Publication Hyperbaric oxygen (HBO) has been proposed to reduce tumour hypoxia by increasing the amount of dissolved oxygen in the plasma. That this actually occurs has not been verified experimentally. This study was performed to explore changes in tumour oxygenation ... Full text Link to item Cite

Patterns and variability of tumor oxygenation in human soft tissue sarcomas, cervical carcinomas, and lymph node metastases.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 1995 Featured Publication PURPOSE: The validity of tumor pO2 measurement as a predictive outcome assay depends upon demonstrating that intrapatient pO2 variation is less than interpatient variation. No consensus exists regarding the appropriate distance between individual measureme ... Full text Link to item Cite

The effect of the perflubron emulsion Oxygent on the calibration characteristics of polarographic oxygen electrodes.

Journal Article Radiother Oncol · December 1994 The perfluorocarbon emulsion Oxygent improves normal tissue oxygenation. A clinical trial is planned to evaluate this effect in tumors. Polarographic oxygen electrodes were calibrated in solutions of saline +/- perflubron to assess whether Oxygent influenc ... Full text Link to item Cite

Pretreatment oxygenation profiles of human soft tissue sarcomas.

Journal Article Int J Radiat Oncol Biol Phys · October 15, 1994 Featured Publication PURPOSE: Tumor oxygenation is thought to influence the radiocurability of many malignancies. Advances in polarographic electrode technology have facilitated the in situ measurement of human tumor pO2. The optimal method of defining a "hypoxic" tumor is not ... Full text Link to item Cite

Cyclophosphamide, doxorubicin, vincristine, and prednisone for primary central nervous system lymphoma: short-duration response and multifocal intracerebral recurrence preceding radiotherapy.

Journal Article Neurology · September 1994 The activity of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) in the treatment of primary central nervous system lymphoma (PCNSL) prior to radiotherapy was studied in six patients. Primary lesions were reduced by 80% or more on contrast ... Full text Link to item Cite

A pilot study of etoposide, vinblastine, and doxorubicin plus involved field irradiation in advanced, previously untreated Hodgkin's disease.

Journal Article Cancer · July 1, 1994 BACKGROUND: Advanced stage Hodgkin's disease (HD) usually is treated with combination chemotherapy with or without supplemental irradiation. The risk of significant acute and long term toxicity when the chemotherapy regimen contains alkylating agents has p ... Full text Link to item Cite

Pilot study of positron emission tomography in patients with advanced head and neck cancer receiving radiotherapy and chemotherapy.

Journal Article Head Neck · 1994 Featured Publication BACKGROUND: Positron emission tomography (PET) provides a noninvasive modality for evaluating the biochemical processes of normal and pathologic tissue. Preliminary reports of F-18 fluorodeoxyglucose (FDG) PET indicate its potential usefulness in evaluatin ... Full text Link to item Cite

A phase I/II trial of twice daily irradiation and concurrent chemotherapy for locally advanced squamous cell carcinoma of the head and neck.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 1994 Featured Publication PURPOSE: This study was designed to test the toxicity and efficacy of a regimen of twice daily irradiation and concurrent multiagent chemotherapy for patients with locally advanced squamous cell carcinoma of the head and neck. METHODS AND MATERIALS: This w ... Full text Link to item Cite

A comparison of tumor and normal tissue microvascular hematocrits and red cell fluxes in a rat window chamber model.

Journal Article Int J Radiat Oncol Biol Phys · January 15, 1993 Featured Publication This laboratory has previously used a window chamber model to measure red blood cell velocity in mammary tumors and normal granulation tissues of the F-344 rat. Because red cell flux and hematocrit more accurately reflect the oxygen carrying potential of b ... Full text Link to item Cite

Effects of the calcium channel blocker flunarizine on the hemodynamics and oxygenation of tumor microvasculature.

Journal Article Radiat Res · October 1992 Flunarizine is a diphenylpiperazine calcium entry blocker that has been shown previously to increase tumor blood flow and sensitivity to radiotherapy via reduction in the radiobiologically significant hypoxic fraction. Two mechanisms of action have been pr ... Link to item Cite

Perivascular oxygen tensions in a transplantable mammary tumor growing in a dorsal flap window chamber.

Journal Article Radiat Res · May 1992 Fischer 344 rats with R3230 Ac mammary carcinomas implanted in dorsal flap window chambers served as a model to obtain measurements of perivascular and stromal oxygen tension in normal and tumor tissues using Whalen recessed-tip microelectrodes (3- to 6-mi ... Link to item Cite

The radiation dose-response relationship in a human glioma xenograft and an evaluation of the influence of glutathione depletion by buthionine sulfoximine.

Journal Article Int J Radiat Oncol Biol Phys · 1992 We have used an extensively characterized human glioma cell line in an athymic mouse model to evaluate new therapeutic approaches for human supratentorial high grade gliomas. The tumor, D-54MG, is a subline of a human anaplastic glioma. Eight days after ho ... Full text Link to item Cite

The radiation dose-response relationship in a human glioma xenograft and an evaluation of the influence of glutathione depletion by buthionine sulfoximine

Journal Article International Journal of Radiation Oncology, Biology, Physics · 1992 We have used an extensively characterized human glioma cell line in an athymic mouse model to evaluate new therapeutic approaches for human supratentorial high grade gliomas. The tumor, D-54MG, is a subline of a human anaplastic glioma. Eight days after ho ... Cite

Improved survival in advanced Hodgkin's disease with the use of combined modality therapy.

Journal Article Int J Radiat Oncol Biol Phys · September 1990 To compare the effectiveness of combined modality therapy and chemotherapy alone for the treatment of advanced Hodgkin's disease (Stages IIB-IV), records of 154 patients who achieved a complete or partial response to induction combination chemotherapy were ... Full text Link to item Cite

CORRECTION

Journal Article INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · November 1, 1988 Link to item Cite

Failure patterns and survival in pediatric soft tissue sarcoma.

Journal Article Int J Radiat Oncol Biol Phys · July 1988 We retrospectively analyzed 44 patients with localized soft tissue sarcomas who were seen and treated at the JCRT, DFCI, and TCH between 1970-1984. Patients with rhabdomyosarcoma were excluded. Primary tumors were located in the following sites: extremitie ... Full text Link to item Cite