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Russell P. Hall III

J. Lamar Callaway Distinguished Professor of Dermatology, in the School of Medicine
Dermatology
Duke Box 3135, Durham, NC 27710
4577 Hosp South, Durham, NC 27710

Selected Publications


Effective Peer Review: Who, Where, or What?

Journal Article JID Innovations · November 1, 2022 Full text Cite

How Do Experts Treat Patients with Bullous Pemphigoid around the World? An International Survey.

Journal Article JID Innov · July 2022 Many treatments are currently proposed for treating patients with bullous pemphigoid (BP). We assessed treatment modalities of BP depending on the different countries, BP extent, and patients' comorbidities. We surveyed worldwide experts about how they tre ... Full text Link to item Cite

SARS-CoV-2 infections in patients with autoimmune blistering disorders: A case series and retrospective analysis.

Journal Article JAAD Int · June 2022 BACKGROUND: Autoimmune blistering disorders (AIBDs) are rare, potentially life-threatening conditions often requiring immunosuppression. Throughout the SARS-CoV-2 pandemic, infection risk and mortality in patients with AIBDs are unknown. OBJECTIVE: We repo ... Full text Link to item Cite

Safety, Tolerability, and Activity of ALXN1830 Targeting the Neonatal Fc Receptor in Chronic Pemphigus.

Journal Article J Invest Dermatol · December 2021 Pemphigus is a debilitating IgG-mediated autoimmune disease requiring better tolerated, more targeted, and rapid onset therapies. ALXN1830 is a humanized IgG4 antibody that blocks neonatal Fc receptor interactions with IgG. A multicenter, open-label safety ... Full text Link to item Cite

JID Innovations and Peer Review

Journal Article JID Innovations · September 1, 2021 Full text Cite

Sharing the Joy of Questioning and Discovery

Journal Article JID Innovations · March 1, 2021 Full text Cite

JID Innovations: Skin Science from Molecules to Population Health.

Journal Article The Journal of investigative dermatology · September 2020 Full text Cite

Data from: Quantifying skin stiffness in graft-versus-host disease, morphea and systemic sclerosis using acoustic radiation force impulse imaging and shear wave elastography

Dataset · July 2, 2020 There is a need for objective, sensitive and reproducible methods of assessing skin sclerosis. We performed a cross sectional, non-interventional study to evaluate the utility of accoustic radiation force impulse (ARFI) and shear wave elasticity imaging (S ... Full text Cite

Data from: Correlation of IgG autoantibodies against acetylcholine receptors and desmogleins in patients with pemphigus treated with steroid sparing agents or rituximab

Dataset · June 2, 2020 Introduction: Autoantibodies (autoAbs) against desmoglein-1 (DSG1) and desmoglein-3 (DSG3) have conventionally been studied and well accepted in the pathogenesis of pemphigus vulgaris (PV) and foliaceus (PF). Recent studies have suggested that non-DSG auto ... Full text Cite

Diagnosis and management of pemphigus: Recommendations of an international panel of experts.

Journal Article J Am Acad Dermatol · March 2020 BACKGROUND: Several European countries recently developed international diagnostic and management guidelines for pemphigus, which have been instrumental in the standardization of pemphigus management. OBJECTIVE: We now present results from a subsequent Del ... Full text Link to item Cite

Correlation of IgG autoantibodies against acetylcholine receptors and desmogleins in patients with pemphigus treated with steroid sparing agents or rituximab.

Journal Article PLoS One · 2020 INTRODUCTION: Autoantibodies (autoAbs) against desmoglein-1 (DSG1) and desmoglein-3 (DSG3) have conventionally been studied and well accepted in the pathogenesis of pemphigus vulgaris (PV) and foliaceus (PF). Recent studies have suggested that non-DSG auto ... Full text Link to item Cite

Dapsone

Chapter · January 1, 2020 Dapsone is a sulfonamide derived antibiotic that is a mainstay of therapy for leprosy and Pneumocystis jirovecii infection. This chapter will however focus on its use in numerous inflammatory skin diseases. Dapsone is highly effective in the management of ... Full text Cite

Inpatient Management of Autoimmune Blistering Diseases: an Update, Review, and Practical Guide

Journal Article Current Dermatology Reports · December 1, 2019 Purpose of Review: Review the evaluation, management, and treatment of hospitalized autoimmune blistering diseases (AIBD) patients based on the current literature and expert opinion. Recent Findings: The cost and prevalence of hospitalization for AIBD pati ... Full text Cite

Effective Peer Review: Who, Where, or What?

Journal Article JID Innovations · November 1, 2022 Full text Cite

How Do Experts Treat Patients with Bullous Pemphigoid around the World? An International Survey.

Journal Article JID Innov · July 2022 Many treatments are currently proposed for treating patients with bullous pemphigoid (BP). We assessed treatment modalities of BP depending on the different countries, BP extent, and patients' comorbidities. We surveyed worldwide experts about how they tre ... Full text Link to item Cite

SARS-CoV-2 infections in patients with autoimmune blistering disorders: A case series and retrospective analysis.

Journal Article JAAD Int · June 2022 BACKGROUND: Autoimmune blistering disorders (AIBDs) are rare, potentially life-threatening conditions often requiring immunosuppression. Throughout the SARS-CoV-2 pandemic, infection risk and mortality in patients with AIBDs are unknown. OBJECTIVE: We repo ... Full text Link to item Cite

Safety, Tolerability, and Activity of ALXN1830 Targeting the Neonatal Fc Receptor in Chronic Pemphigus.

Journal Article J Invest Dermatol · December 2021 Pemphigus is a debilitating IgG-mediated autoimmune disease requiring better tolerated, more targeted, and rapid onset therapies. ALXN1830 is a humanized IgG4 antibody that blocks neonatal Fc receptor interactions with IgG. A multicenter, open-label safety ... Full text Link to item Cite

JID Innovations and Peer Review

Journal Article JID Innovations · September 1, 2021 Full text Cite

Sharing the Joy of Questioning and Discovery

Journal Article JID Innovations · March 1, 2021 Full text Cite

JID Innovations: Skin Science from Molecules to Population Health.

Journal Article The Journal of investigative dermatology · September 2020 Full text Cite

Data from: Quantifying skin stiffness in graft-versus-host disease, morphea and systemic sclerosis using acoustic radiation force impulse imaging and shear wave elastography

Dataset · July 2, 2020 There is a need for objective, sensitive and reproducible methods of assessing skin sclerosis. We performed a cross sectional, non-interventional study to evaluate the utility of accoustic radiation force impulse (ARFI) and shear wave elasticity imaging (S ... Full text Cite

Data from: Correlation of IgG autoantibodies against acetylcholine receptors and desmogleins in patients with pemphigus treated with steroid sparing agents or rituximab

Dataset · June 2, 2020 Introduction: Autoantibodies (autoAbs) against desmoglein-1 (DSG1) and desmoglein-3 (DSG3) have conventionally been studied and well accepted in the pathogenesis of pemphigus vulgaris (PV) and foliaceus (PF). Recent studies have suggested that non-DSG auto ... Full text Cite

Diagnosis and management of pemphigus: Recommendations of an international panel of experts.

Journal Article J Am Acad Dermatol · March 2020 BACKGROUND: Several European countries recently developed international diagnostic and management guidelines for pemphigus, which have been instrumental in the standardization of pemphigus management. OBJECTIVE: We now present results from a subsequent Del ... Full text Link to item Cite

Correlation of IgG autoantibodies against acetylcholine receptors and desmogleins in patients with pemphigus treated with steroid sparing agents or rituximab.

Journal Article PLoS One · 2020 INTRODUCTION: Autoantibodies (autoAbs) against desmoglein-1 (DSG1) and desmoglein-3 (DSG3) have conventionally been studied and well accepted in the pathogenesis of pemphigus vulgaris (PV) and foliaceus (PF). Recent studies have suggested that non-DSG auto ... Full text Link to item Cite

Dapsone

Chapter · January 1, 2020 Dapsone is a sulfonamide derived antibiotic that is a mainstay of therapy for leprosy and Pneumocystis jirovecii infection. This chapter will however focus on its use in numerous inflammatory skin diseases. Dapsone is highly effective in the management of ... Full text Cite

Inpatient Management of Autoimmune Blistering Diseases: an Update, Review, and Practical Guide

Journal Article Current Dermatology Reports · December 1, 2019 Purpose of Review: Review the evaluation, management, and treatment of hospitalized autoimmune blistering diseases (AIBD) patients based on the current literature and expert opinion. Recent Findings: The cost and prevalence of hospitalization for AIBD pati ... Full text Cite

Subacute cutaneous lupus erythematosus and dermatomyositis associated with anti-programmed cell death 1 therapy.

Journal Article Br J Dermatol · September 2019 Programmed cell death 1 (PD-1) blockade has rapidly emerged as an effective therapy for a wide variety of metastatic malignancies. It has been associated with multiple immune-related adverse effects, including cutaneous eruptions. We describe two patients ... Full text Link to item Cite

Induction of hair follicle neogenesis with cultured mouse dermal papilla cells in de novo regenerated skin tissues.

Journal Article J Tissue Eng Regen Med · September 2019 De novo skin regeneration with human keratinocytes amplified in culture is a life-saving procedure for patients with extensive skin loss and chronic wounds. It also provides a valuable platform for gene function and therapeutic assessments. Nevertheless, t ... Full text Link to item Cite

Interrater Reliability of Clinical Grading Measures for Cutaneous Chronic Graft-vs-Host Disease.

Journal Article JAMA Dermatol · July 1, 2019 IMPORTANCE: Cutaneous chronic graft-vs-host disease (cGVHD) is common after allogeneic hematopoietic stem cell transplant and is often associated with poor patient outcomes. A reliable and practical method for assessing disease severity and response to the ... Full text Link to item Cite

Stephen I. Katz MD PhD 1941-2019.

Journal Article Br J Dermatol · May 2019 Full text Link to item Cite

Chapter 61: Linear Immunoglobulin A Dermatosis and Chronic Bullous Disease of Childhood

Chapter · 2019 "Important general basic science concepts are extensively covered in dedicated chapters appearing in an early section of the book, allowing subsequent clinical chapters to focus on relevant disease-specific pathophysiology in addition to ... ... Cite

Bullous Diseases of the Skin and Mucous Membranes

Chapter · January 1, 2019 Autoimmune blistering diseases are characterized by epidermal or subepidermal blistering of the skin and mucosal surfaces. Both genetic and environmental factors play a role in their development. Pathogenic autoantibodies against epidermal and basement mem ... Full text Cite

Serum Interleukin-8, Osteopontin, and Monocyte Chemoattractant Protein 1 Are Associated With Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease.

Journal Article Hepatol Commun · November 2018 The severity of hepatic fibrosis is the primary predictor of liver-related morbidity and mortality in patients with nonalcoholic fatty liver disease (NAFLD). Unfortunately, noninvasive serum biomarkers for NAFLD-associated fibrosis are limited. We analyzed ... Full text Link to item Cite

International Bullous Diseases Group: consensus on diagnostic criteria for epidermolysis bullosa acquisita.

Journal Article Br J Dermatol · July 2018 BACKGROUND: Epidermolysis bullosa acquisita (EBA) is a complex autoimmune bullous disease disease with variable clinical presentations and multiple possible diagnostic tests, making an international consensus on the diagnosis of EBA essential. OBJECTIVES: ... Full text Link to item Cite

Data from: Comparison of rituximab and conventional adjuvant therapy for pemphigus vulgaris: A retrospective analysis

Dataset · June 5, 2018 Background: Rituximab is a promising steroid sparing agent used in the treatment of moderate to severe pemphigus vulgaris. Its exact place in the algorithm of pemphigus treatment, vis-a-vis other, conventional adjuvant therapy (CAT) is not known. Objectiv ... Full text Cite

Eosinophils Mediate Tissue Injury in the Autoimmune Skin Disease Bullous Pemphigoid.

Journal Article J Invest Dermatol · May 2018 Eosinophils are typically associated with unique inflammatory settings, including allergic inflammation and helminth infections. However, new information suggests that eosinophils contribute more broadly to inflammatory responses and participate in local i ... Full text Link to item Cite

Noninvasive optical spectroscopy for identification of non-melanoma skin cancer: Pilot study.

Journal Article Lasers Surg Med · March 2018 OBJECTIVE: Optical spectroscopy offers a noninvasive alternative to biopsy as a first-line screening tool for suspicious skin lesions. This study sought to define several optical parameters across malignant and benign tissue types. STUDY DESIGN: Prospectiv ... Full text Link to item Cite

Comparison of rituximab and conventional adjuvant therapy for pemphigus vulgaris: A retrospective analysis.

Journal Article PLoS One · 2018 BACKGROUND: Rituximab is a promising steroid sparing agent used in the treatment of moderate to severe pemphigus vulgaris. Its exact place in the algorithm of pemphigus treatment, vis-à-vis other, conventional adjuvant therapy (CAT) is not known. OBJECTIVE ... Full text Link to item Cite

Perspective From the 5th International Pemphigus and Pemphigoid Foundation Scientific Conference.

Journal Article Front Med (Lausanne) · 2018 The 5th Scientific Conference of the International Pemphigus and Pemphigoid Foundation (IPPF), "Pemphigus and Pemphigoid: A New Era of Clinical and Translational Science" was held in Orlando, Florida, on May 15-16, 2018. Scientific sessions covered recent, ... Full text Link to item Cite

Clinical Implications of Direct Immunofluorescence Findings in Patients With Ocular Mucous Membrane Pemphigoid.

Journal Article Am J Ophthalmol · November 2017 PURPOSE: To examine the clinical implications of positive or negative direct immunofluorescence biopsies (DIF) in patients with clinically typical ocular mucous membrane pemphigoid (MMP). DESIGN: Retrospective cohort study. METHODS: The study population wa ... Full text Link to item Cite

Validation and comparison of quality-of-life measures for topical 5-fluorouracil treatment: results from a randomized controlled trial.

Journal Article Clin Exp Dermatol · July 2017 BACKGROUND: Topical 5-fluorouracil (5-FU) is commonly used for high-risk patients with keratinocyte carcinoma (KC). Skindex and Skin Cancer Index (SCI) are validated instruments to measure quality of life (QoL) of patients with KC and those who have had su ... Full text Link to item Cite

TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis.

Journal Article J Invest Dermatol · April 2017 Mascarenhas et al. report that TRPV4 expression is upregulated in mast cells in response to the proteolytic cathelicidin fragment LL37 in a murine rosacea model and that TRPV4 loss of function attenuates mast cell degranulation. These findings render TRPV4 ... Full text Link to item Cite

KIND1 Loss Sensitizes Keratinocytes to UV-Induced Inflammatory Response and DNA Damage.

Journal Article J Invest Dermatol · February 2017 Loss of function of KIND1, a cytoskeletal protein involved in β1-integrin function, causes Kindler syndrome, a genetic disease characterized by skin fragility, photosensitivity, and increased risk of squamous cell carcinoma. Dysregulation of β1-integrin un ... Full text Link to item Cite

Should all patients undergoing treatment with biologic agents be screened annually for latent tuberculosis infection with an interferon gamma release assay?

Journal Article J Dermatolog Treat · August 2016 Systemic biologic therapy has become commonplace for the treatment of a variety of inflammatory dermatologic conditions, particularly psoriasis. Screening for latent tuberculosis infection (LTBI) is recommended prior to initiation of systemic biologic agen ... Full text Link to item Cite

Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch.

Journal Article J Biol Chem · May 6, 2016 TRPV4 ion channels function in epidermal keratinocytes and in innervating sensory neurons; however, the contribution of the channel in either cell to neurosensory function remains to be elucidated. We recently reported TRPV4 as a critical component of the ... Full text Open Access Link to item Cite

Redefining the roles of apoptotic factors in carcinogenesis.

Journal Article Mol Cell Oncol · May 2016 In a recent study we reported that mammalian cells exposed to stress such as ionizing radiation can survive with activation of caspase-3 or caspase-7. We found that sublethal activation of the executioner caspases promotes chemical- and radiation-induced g ... Full text Link to item Cite

Use of Drawing Lithography-Fabricated Polyglycolic Acid Microneedles for Transdermal Delivery of Itraconazole to a Human Basal Cell Carcinoma Model Regenerated on Mice.

Journal Article JOM (1989) · April 2016 Itraconazole is a triazole agent that is routinely used for treatment of nail infections and other fungal infections. Recent studies indicate that itraconazole can also inhibit the growth of basal cell carcinoma (BCC) through suppression of the Sonic Hedge ... Full text Link to item Cite

Inflammation Markers and Major Depressive Disorder in Patients With Chronic Heart Failure: Results From the Sertraline Against Depression and Heart Disease in Chronic Heart Failure Study.

Journal Article Psychosom Med · September 2015 BACKGROUND: Major depressive disorder (MDD) and chronic heart failure (CHF) have in common heightening states of inflammation, manifested by elevated inflammation markers such as C-reactive protein. This study compared inflammatory biomarker profiles in pa ... Full text Link to item Cite

Long-term Efficacy of Topical Fluorouracil Cream, 5%, for Treating Actinic Keratosis: A Randomized Clinical Trial.

Conference JAMA Dermatol · September 2015 IMPORTANCE: Topical fluorouracil was demonstrated to be effective in reducing the number of actinic keratoses (AKs) for up to 6 months, but no randomized trials studied its long-term efficacy. OBJECTIVE: To evaluate the long-term efficacy of a single cours ... Full text Link to item Cite

RNA-Seq and ChIP-Seq Reveal SQSTM1/p62 as a Key Mediator of JunB Suppression of NF-κB-Dependent Inflammation

Journal Article Journal of Investigative Dermatology · April 20, 2015 Mice with epidermal deletion of JunB transcription factor displayed a psoriasis-like inflammation. The relevance of these findings to humans and the mechanisms mediating JunB function are not fully understood. Here we demonstrate that impaired JunB functio ... Full text Cite

Caspase-3 promotes genetic instability and carcinogenesis.

Journal Article Mol Cell · April 16, 2015 Apoptosis is typically considered an anti-oncogenic process since caspase activation can promote the elimination of genetically unstable or damaged cells. We report that a central effector of apoptosis, caspase-3, facilitates rather than suppresses chemica ... Full text Link to item Cite

RNA-Seq and ChIP-Seq reveal SQSTM1/p62 as a key mediator of JunB suppression of NF-κB-dependent inflammation.

Journal Article J Invest Dermatol · April 2015 Mice with epidermal deletion of JunB transcription factor displayed a psoriasis-like inflammation. The relevance of these findings to humans and the mechanisms mediating JunB function are not fully understood. Here we demonstrate that impaired JunB functio ... Full text Open Access Link to item Cite

A multicentre randomized trial of the treatment of patients with pemphigus vulgaris with infliximab and prednisone compared with prednisone alone.

Journal Article Br J Dermatol · March 2015 BACKGROUND: Pemphigus vulgaris (PV) is a blistering disease and tumour necrosis factor-α has a role in its pathogenesis. OBJECTIVES: To evaluate the safety of infliximab (IFX) with prednisone compared with prednisone alone in the treatment of PV. In additi ... Full text Link to item Cite

Definitions and outcome measures for mucous membrane pemphigoid: recommendations of an international panel of experts.

Journal Article J Am Acad Dermatol · January 2015 Mucous membrane pemphigoid encompasses a group of autoimmune bullous diseases with a similar phenotype characterized by subepithelial blisters, erosions, and scarring of mucous membranes, skin, or both. Although knowledge about autoimmune bullous disease i ... Full text Link to item Cite

Treatment of Dermatitis Herpetiformis

Chapter · January 1, 2015 Dapsone, a sulfone, was synthesized in the early twentieth century and has held longtime FDA approval to treat dermatitis herpetiformis and leprosy. However, unlabeled uses of dapsone have become prevalent among dermatologist, especially in autoimmune bull ... Full text Cite

Management of Bullous Pemphigoid

Chapter · January 1, 2015 Dapsone, a sulfone, was synthesized in the early twentieth century and has held longtime FDA approval to treat dermatitis herpetiformis and leprosy. However, unlabeled uses of dapsone have become prevalent among dermatologist, especially in autoimmune bull ... Full text Cite

Bullous Pemphigoid (Cutaneous Pemphigoid): The Spectrum of Clinical Presentations

Chapter · January 1, 2015 Acantholytic EB is a very rare subtype of suprabasal EB characterised by congenital widespread skin erosions and severe skin barrier dysfunction due to acantholysis, leading to early demise. The molecular pathomechanism involves either loss, reduced number ... Full text Cite

Keratinocyte growth regulation TRP-ed up over downregulated TRPV4?

Journal Article J Invest Dermatol · September 2014 This commentary on an exciting new study (Fusi et al., 2014) puts the finding of TRPV4 downregulation in several nonmelanoma skin cancers into context. The original paper point toward possible use of TRPV4 as dermatopathologic marker, also toward the possi ... Full text Link to item Cite

Updates on the management of autoimmune blistering diseases.

Journal Article Skin Therapy Lett · 2014 Autoimmune blistering diseases are rare, but potentially debilitating cutaneous disorders characterized by varying degrees of mucosal and cutaneous bullae formation. Topical therapy is appropriate for mild and even some moderate disease activity, but syste ... Link to item Cite

Effects of Y27632 on keratinocyte procurement and wound healing.

Journal Article Clin Exp Dermatol · October 2013 A number of Rho-kinase inhibitors have been developed for various clinical applications. We examined the effects of the Rho-kinase inhibitor Y27632 on keratinocyte proliferation and migration, and found that it promoted primary human keratinocyte prolifera ... Full text Link to item Cite

Neo-epitope tissue transglutaminase autoantibodies as a biomarker of the gluten sensitive skin disease--dermatitis herpetiformis.

Journal Article Clin Chim Acta · January 16, 2013 BACKGROUND: The deamidated gliadin peptides (DGP) cross linked to human tissue transglutaminase (tTg) comprises a novel neo-epitope structure (Neo-tTg) for serological screening of celiac disease (CD). Our aim is to verify anti-Neo-tTg IgA and IgG in adult ... Full text Link to item Cite

CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways.

Journal Article J Invest Dermatol · January 2013 The molecular mechanisms mediating cylindromatosis (CYLD) tumor suppressor function appear to be manifold. Here, we demonstrate that, in contrast to the increased levels of phosphorylated c-Jun NH(2)-terminal kinase (pJNK), CYLD was decreased in a majority ... Full text Open Access Link to item Cite

Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function.

Journal Article Leukemia · January 2013 Chronic lymphocytic leukemia (CLL) can be immunosuppressive in humans and mice, and CLL cells share multiple phenotypic markers with regulatory B cells that are competent to produce interleukin (IL)-10 (B10 cells). To identify functional links between CLL ... Full text Link to item Cite

CYLD inhibits melanoma growth and progression through suppression of the jnk/ap-1 and β1-integrin signaling pathways

Journal Article Journal of Investigative Dermatology · 2013 The molecular mechanisms mediating cylindromatosis (CYLD) tumor suppressor function appear to be manifold. Here, we demonstrate that, in contrast to the increased levels of phosphorylated c-Jun NH 2 -terminal kinase (pJNK), CYLD was decreased in a majority ... Full text Cite

Dapsone

Chapter · November 16, 2012 Full text Cite

Predictors of basal cell carcinoma in high-risk patients in the VATTC (VA Topical Tretinoin Chemoprevention) trial.

Journal Article J Invest Dermatol · November 2012 Basal cell carcinoma (BCC) is the most common cancer in the United States today, and patients who have had one are likely to have multiple carcinomas over time. Predictors of new BCCs on the face and ears among those at very high risk have not been studied ... Full text Link to item Cite

Tretinoin and the prevention of keratinocyte carcinoma (Basal and squamous cell carcinoma of the skin): a veterans affairs randomized chemoprevention trial.

Journal Article J Invest Dermatol · June 2012 Keratinocyte carcinoma (KC) is the most common cancer in the United States, with no proven means for prevention other than systemic retinoids, which have significant toxicity, and sunscreen. Topical tretinoin has been used for KC chemoprevention, although ... Full text Link to item Cite

Management of dermatitis herpetiformis.

Journal Article Immunol Allergy Clin North Am · May 2012 The major treatment strategies for DH are gluten restriction or medical treatment with sulfones. Control of the cutaneous manifestations, but not the gastrointestinal changes, is rapid with dapsone. In addition to control of the cutaneous signs and symptom ... Full text Link to item Cite

Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation.

Journal Article Immunol Allergy Clin North Am · May 2012 Dermatitis herpetiformis (DH) is an autoimmune blistering skin disease in which antigen presentation in the gastrointestinal mucosa results in cutaneous IgA deposition and distinct, neutrophil-driven cutaneous lesions. Our findings suggest that the qualita ... Full text Link to item Cite

Definitions and outcome measures for bullous pemphigoid: recommendations by an international panel of experts.

Journal Article J Am Acad Dermatol · March 2012 Our scientific knowledge of bullous pemphigoid (BP) has dramatically progressed in recent years. However, despite the availability of various therapeutic options for the treatment of inflammatory diseases, only a few multicenter controlled trials have help ... Full text Link to item Cite

Leukocytoclastic vasculitis as the presenting feature of dermatitis herpetiformis.

Journal Article Arch Dermatol · November 2011 BACKGROUND: Dermatitis herpetiformis is an autoimmune disease typically characterized by pruritic vesicles located on the extensor surfaces. Classic disease consists of neutrophils in the dermal papillae. Additional histopathologic findings include fibrin ... Full text Link to item Cite

Management of dermatitis herpetiformis.

Journal Article Dermatol Clin · October 2011 The major treatment strategies for DH are gluten restriction or medical treatment with sulfones. Control of the cutaneous manifestations, but not the gastrointestinal changes, is rapid with dapsone. In addition to control of the cutaneous signs and symptom ... Full text Link to item Cite

Evidence-based management of bullous pemphigoid.

Journal Article Dermatol Clin · October 2011 Bullous pemphigoid (BP) is the most common autoimmune subepidermal bullous disease typically affecting the elderly. Although different therapeutic regimens have been proposed, a review of the evidence is needed to aid clinicians in their decision making an ... Full text Link to item Cite

Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation.

Journal Article Dermatol Clin · July 2011 Dermatitis herpetiformis (DH) is an autoimmune blistering skin disease in which antigen presentation in the gastrointestinal mucosa results in cutaneous IgA deposition and distinct, neutrophil-driven cutaneous lesions. Our findings suggest that the qualita ... Full text Link to item Cite

c-Jun promotes whereas JunB inhibits epidermal neoplasia.

Journal Article J Invest Dermatol · May 2011 Deregulation of the activator protein 1 (AP1) family gene regulators has been implicated in a wide range of diseases, including cancer. In this study we report that c-Jun was activated in human squamous cell carcinoma (SCC) and coexpression of c-Jun with o ... Full text Link to item Cite

Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells.

Journal Article Blood · January 13, 2011 Regulatory B cells control inflammation and autoimmunity in mice, including the recently identified IL-10-competent B10 cell subset that represents 1% to 3% of spleen B cells. In this study, a comparable IL-10-competent B10 cell subset was characterized in ... Full text Link to item Cite

The c-Jun NH2-terminal kinase 2 plays a dominant role in human epidermal neoplasia.

Journal Article Cancer Res · April 15, 2010 The c-Jun NH(2)-terminal kinase (JNK) signaling cascade has been implicated in a wide range of diseases, including cancer. It is unclear how different JNK proteins contribute to human cancer. Here, we report that JNK2 is activated in more than 70% of human ... Full text Link to item Cite

Reliability and convergent validity of two outcome instruments for pemphigus.

Journal Article J Invest Dermatol · October 2009 A major obstacle in performing multicenter controlled trials for pemphigus is the lack of a validated disease activity scoring system. Here, we assess the reliability and convergent validity of the PDAI (pemphigus disease area index). A group of 10 dermato ... Full text Link to item Cite

Tolerability of high-dose topical tretinoin: the Veterans Affairs Topical Tretinoin Chemoprevention Trial.

Journal Article Br J Dermatol · October 2009 BACKGROUND: Topical tretinoin is a medication commonly used for acne that has potential application in the long-term treatment of photodamaged skin. However, there are few published data regarding the tolerability of high-dose tretinoin with long-term use. ... Full text Link to item Cite

Topical tretinoin therapy and all-cause mortality.

Journal Article Arch Dermatol · January 2009 OBJECTIVE: To evaluate the relation of topical tretinoin, a commonly used retinoid cream, with all-cause mortality in the Veterans Affairs Topical Tretinoin Chemoprevention Trial (VATTC). The planned outcome of this trial was risk of keratinocyte carcinoma ... Full text Link to item Cite

A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation.

Journal Article J Am Acad Dermatol · September 2008 BACKGROUND: Skin cancer and photoaging changes result from ultraviolet (UV)-induced oxidative stress. Topical antioxidants may protect skin from these effects. OBJECTIVE: We sought to determine whether a stable topical formulation of 15% L-ascorbic acid, 1 ... Full text Link to item Cite

Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus.

Journal Article J Am Acad Dermatol · June 2008 Our scientific knowledge of pemphigus has dramatically progressed in recent years. However, despite the availability of various therapeutic options for the treatment of inflammatory diseases, only a few multicenter controlled trials have helped to define e ... Full text Link to item Cite

Expression of antimicrobial peptides in the normal and involved skin of patients with infective cellulitis.

Journal Article J Infect Dis · November 1, 2007 BACKGROUND: Endogenous antimicrobial peptides participate in the innate defense of skin against a variety of pathogens. The systemic expression of these peptides in normal-appearing skin of patients with infective cellulitis is unknown. METHODS: Study pati ... Full text Link to item Cite

Serum IL-8 in patients with dermatitis herpetiformis is produced in response to dietary gluten.

Journal Article J Invest Dermatol · September 2007 Patients with dermatitis herpetiformis (DH) have a gluten-sensitive enteropathy and while on gluten-containing diets have elevated levels of serum IL-8. We hypothesized that the mucosal immune response to gluten is responsible for the elevated serum IL-8. ... Full text Link to item Cite

Announcing "milestones in cutaneous biology"

Journal Article Journal of Investigative Dermatology · February 1, 2007 Full text Cite

A socratic dialogue on impact factors.

Journal Article J Invest Dermatol · September 2006 Full text Link to item Cite

Development of ocular disease in patients with mucous membrane pemphigoid involving the oral mucosa.

Journal Article Br J Ophthalmol · August 2006 AIM: To determine the rate of development of ocular disease in patients presenting with mucous membrane pemphigoid (MMP) involving their oral mucosa. METHODS: Diagnosis of oral MMP was made on the basis of clinical signs, histology, and direct and indirect ... Full text Link to item Cite

Picking your peers.

Journal Article J Invest Dermatol · July 2006 Full text Link to item Cite

Increases in stimulated secretion of proinflammatory cytokines by blood monocytes following arousal of negative affect: the role of insulin resistance as moderator.

Journal Article Brain Behav Immun · July 2006 Featured Publication We examined the effect of negative affect on changes in stimulated secretion of cytokines by blood monocytes and determined whether insulin resistance (IR), as indexed by the Homeostasis Model Assessment (HOMA), moderated these associations in 58 healthy m ... Full text Link to item Cite

Errors in the lab and in publications.

Journal Article J Invest Dermatol · June 2006 Full text Link to item Cite

Cutaneous endothelial cell activation in normal skin of patients with dermatitis herpetiformis associated with increased serum levels of IL-8, sE-Selectin, and TNF-alpha.

Journal Article J Invest Dermatol · June 2006 Featured Publication The mechanisms that lead to the development of skin lesions in patients with dermatitis herpetiformis (DH) are not known. We hypothesized that an ongoing immune response in the gut of patients with DH would result in an increase in circulating cytokines an ... Full text Link to item Cite

A prospective clinical and pathological examination of injection site reactions with the HIV-1 fusion inhibitor enfuvirtide.

Journal Article Antivir Ther · 2006 OBJECTIVE: Antiretroviral regimens containing the fusion inhibitor enfuvirtide (ENF) are associated with sustained viral suppression and immunological benefit. However, local injection site reactions (ISR) occur in the majority of patients. The aim of this ... Link to item Cite

Successful treatment of refractory childhood pemphgus vulgaris with anti-CD20 monoclonal antibody (rituximab).

Journal Article Pediatr Dermatol · 2005 Featured Publication Pemphigus vulgaris is an uncommon autoimmune blistering skin disorder that is particularly rare in children. Immunosuppressive treatment can be challenging. Rituximab (anti-CD20 monoclonal antibody) has been used to treat autoimmune disorders by depletion ... Full text Link to item Cite

Perspectives: A new series of articles begins in this issue of JID

Journal Article Journal of Investigative Dermatology · January 1, 2005 Full text Cite

Localized facial macules and vesicles.

Journal Article Arch Dermatol · March 2004 Full text Link to item Cite

Patient and clinician satisfaction with a store-and-forward teledermatology consult system.

Journal Article Telemed J E Health · 2004 Featured Publication The aim of this study was to assess satisfaction with and acceptance of a store and forward teledermatology consult system among patients, referring primary-care clinicians, and consultant dermatologists. As part of a randomized clinical trial that compare ... Full text Link to item Cite

Increased E-selectin, IL-8 and IL-10 gene expression in human skin after minimal trauma.

Journal Article Exp Dermatol · December 2003 Featured Publication While clinical observations suggest that trauma to the skin plays a critical role in the induction of skin lesions in some skin diseases, the mechanism by which these lesions are induced is not known. We have postulated that minor trauma to the skin may le ... Full text Link to item Cite

Early melanoma detection: nonuniform dermoscopic features and growth.

Journal Article J Am Acad Dermatol · May 2003 BACKGROUND: Dermoscopy alone is not sufficient to detect all early melanomas. Total body photos reveal growth of melanomas but also reveal growth of melanocytic nevi. OBJECTIVE: We set out to determine whether a simplified algorithm on the basis of nonunif ... Full text Link to item Cite

An economic analysis of a store and forward teledermatology consult system.

Journal Article Telemed J E Health · 2003 Our objective was to assess the economic impact of store-and-forward teledermatology in a United States Department of Veterans Affairs (VA) health care setting. Patients being referred to the Dermatology Consult Service from the Primary Care Clinics at the ... Full text Link to item Cite

Neutrophil CD11b, L-selectin and Fc IgA receptors in patients with dermatitis herpetiformis.

Journal Article Br J Dermatol · December 2002 Featured Publication BACKGROUND: The skin lesions found in patients with dermatitis herpetiformis (DH) are characterized by the presence of neutrophils at the dermal papillary tips in areas where the diagnostic cutaneous IgA deposits are found. Although the presence of the ski ... Full text Link to item Cite

Combination treatment of bullous pemphigoid with anti-CD20 and anti-CD25 antibodies in a patient with chronic graft-versus-host disease.

Journal Article Bone Marrow Transplant · September 2002 Featured Publication In this case report we describe a novel treatment with two chimeric monoclonal antibodies (MoAb) targeting the autoimmune B cell clone responsible for bullous pemphigoid (BP) as a manifestation of steroid refractory chronic graft-versus-host disease (GVHD) ... Full text Link to item Cite

Teledermatology's impact on time to intervention among referrals to a dermatology consult service.

Journal Article Telemed J E Health · 2002 The aim of this study was to determine if a teledermatology consult system, using store-and-forward digital imaging technology, results in patients achieving a shorter time from referral date to date of initial definitive intervention when compared to a tr ... Full text Link to item Cite

Dapsone

Journal Article Dermatologic Therapy · January 1, 2002 Dapsone and other sulfonamides have been used successfully in the treatment of patients with a variety of blistering skin diseases. The patients most likely to respond to dapsone therapy have a predominantly neutrophilic infiltrate in their skin. Therefore ... Full text Cite

Combination treatment of bullous skin gvhd with ANTI-CD20 and ANTI-CD25 antibodies

Journal Article Blood · December 1, 2000 We report on a novel treatment for bullous skin GVHD prompted by immunologie monitoring. A 9 year old boy with ALL in CR3 received a 4/6 HLA-matched unrelated placental graft. Grade 3 aGVHD of the gut 5 weeks after transplant was controlled with steroids, ... Cite

Increased production of IL-4 by gut T-cell lines from patients with dermatitis herpetiformis compared to patients with isolated gluten-sensitive enteropathy.

Journal Article Dig Dis Sci · October 2000 Featured Publication Dermatitis herpetiformis (DH) and isolated gluten-sensitive enteropathy (GSE) are gluten-sensitive diseases in which ingestion of dietary gluten results in the development of clinical disease. Patients with DH develop cutaneous IgA deposits and a severe sk ... Full text Link to item Cite

TCR Vbeta expression in the small bowel of patients with dermatitis herpetiformis and gluten sensitive enteropathy. Limited expression in dermatitis herpetiformis and treated asymptomatic gluten sensitive enteropathy.

Journal Article Exp Dermatol · August 2000 Featured Publication Dermatitis herpetiformis (DH) is a blistering skin disease characterized by cutaneous deposits of IgA and an associated, most often asymptomatic, gluten sensitive enteropathy (GSE). Gluten sensitive enteropathy is also seen in patients that do not have ski ... Full text Link to item Cite

The 120-kDa soluble ectodomain of type XVII collagen is recognized by autoantibodies in patients with pemphigoid and linear IgA dermatosis.

Journal Article Br J Dermatol · July 2000 Featured Publication BACKGROUND: Type XVII collagen promotes adhesion of basal keratinocytes to epidermal basement membrane, and is the target of disease in patients with certain inherited or acquired blistering diseases. Two forms of type XVII collagen are produced by culture ... Full text Link to item Cite

Reliability and accuracy of dermatologists' clinic-based and digital image consultations.

Journal Article J Am Acad Dermatol · November 1999 BACKGROUND: Telemedicine technology holds great promise for dermatologic health care delivery. However, the clinical outcomes of digital image consultations (teledermatology) must be compared with traditional clinic-based consultations. OBJECTIVE: Our purp ... Full text Link to item Cite

Expression of interleukin-4 and interferon-gamma in the small bowel of patients with dermatitis herpetiformis and isolated gluten-sensitive enteropathy.

Journal Article Dig Dis Sci · October 1999 Featured Publication Although possessing a morphologically similar small bowel abnormality to patients with isolated gluten-sensitive enteropathy (GSE), patients with dermatitis herpetiformis (DH) have few gastrointestinal symptoms and exhibit blistering skin lesions and cutan ... Full text Link to item Cite

Characterization of skin cytokines in bullous pemphigoid and pemphigus vulgaris.

Journal Article Br J Dermatol · June 1999 Featured Publication The purpose of this study was to determine cytokine and cell marker expression in perilesional skin biopsies from patients with the autoimmune blistering diseases bullous pemphigoid (BP, n = 21) and pemphigus vulgaris (PV, n = 7). Immunohistochemistry and ... Full text Link to item Cite

Reliability and accuracy of dermatologists' digital image consultations

Journal Article Journal of Investigative Medicine · January 1, 1999 We compared the reliability and accuracy of diagnoses and management plans generated by dermatologists performing digital image review with dermatologists performing traditional clinic-based consultations. Our patient sample included referrals to a dermato ... Cite

A pilot trial of digital imaging in skin cancer.

Journal Article J Telemed Telecare · 1998 We have used inexpensive off-the-shelf equipment for store-and-forward teledermatology and compared the precision and accuracy of digital image consultations with conventional, clinic-based consultations. Thirteen lesions were studied on 12 patients referr ... Full text Link to item Cite

Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-expressed recombinant desmogleins.

Journal Article J Immunol · August 15, 1997 Featured Publication Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune skin diseases caused by autoantibodies against desmoglein (Dsg) 3 and Dsg1, respectively. Routine immunofluorescence testing of skin and serum from patients cannot distinguish between thes ... Link to item Cite

Primary care clinicians' performance for detecting actinic keratoses and skin cancer.

Journal Article Arch Intern Med · May 12, 1997 BACKGROUND: If skin cancer screening is to become widely adopted, its effectiveness depends on the ability of primary care clinicians to detect cutaneous malignancies. OBJECTIVE: To assess primary care clinicians' proficiency for detecting skin cancers and ... Link to item Cite

Comparative epitope mapping of sera from United States (US) and Japanese patients with bullous pemphigoid (BP) to fusion proteins encoded by BPAG1.

Journal Article J Dermatol Sci · September 1996 Featured Publication Sera from patients with bullous pemphigoid (BP) from the United States (US), Japan, and Britain demonstrate similar reactivity to the major target antigens BPAG1 and BPAG2. The purpose of the present study was to determine if the epitope specificity of cir ... Full text Link to item Cite

Primary care clinicians' performance in the diagnosis of actinic keratoses and skin cancer

Journal Article Journal of Investigative Medicine · January 1, 1996 If skin cancer screening is to become widely adopted, increasing its accessibility would be best achieved by incorporating screening examinations into routine patient care by primary care clinicians (PCCs). Because PCCs' proficiency for detecting skin canc ... Cite

The influence of history on interobserver agreement for diagnosing actinic keratoses and malignant skin lesions.

Journal Article J Am Acad Dermatol · October 1995 BACKGROUND: Quantifying interobserver diagnostic agreement is necessary to evaluate skin cancer screening programs, but estimates of variability are incomplete. OBJECTIVE: We sought to measure agreement between dermatologists for diagnosing actinic keratos ... Full text Link to item Cite

Peripheral blood mononuclear cells from patients with bullous pemphigoid have an increased frequency of response to synthetic peptides encoded by BPAG1.

Journal Article J Invest Dermatol · July 1994 We determined the response of peripheral blood mononuclear cells from patients with bullous pemphigoid and normal subjects to synthetic peptides encoded by BPAG1. Peripheral blood mononuclear cells from patients and normal subjects were cocultured in the p ... Full text Link to item Cite

IgA antibodies against reticulin and endomysium in the serum and gastrointestinal secretions of patients with dermatitis herpetiformis.

Journal Article Dermatology · 1994 Although IgA is present in the skin of patients with dermatitis herpetiformis (DH), the relationship of that IgA to the mucosal immune response is not known. The purpose of this study was to determine if IgA antibodies directed against tissue antigens, whi ... Full text Link to item Cite

Cross-reactive idiotypes in the sera of patients with bullous pemphigoid express anti-basement-membrane-zone activity.

Journal Article Dermatology · 1994 We have previously generated a monoclonal anti-idiotypic antibody (antiId 3-17) specific for a cross-reactive idiotype (CRI) present in sera and bound at the basement membrane zone (BMZ) in some patients with bullous pemphigoid (BP). The purpose of the pre ... Full text Link to item Cite

IgG antibodies from patients with bullous pemphigoid bind to fusion proteins encoded by BPAg1 cDNA.

Journal Article J Invest Dermatol · December 1993 Bullous pemphigoid (BP) is an autoimmune blistering skin disease characterized in part by the presence of circulating and tissue-bound IgG antibodies directed against the epidermal basement membrane zone. IgG from over 95% of patients with BP have been sho ... Full text Link to item Cite

Rabbits immunized with a peptide encoded for by the 230-kD bullous pemphigoid antigen cDNA develop an enhanced inflammatory response to UVB irradiation: a potential animal model for bullous pemphigoid.

Journal Article J Invest Dermatol · July 1993 Previous attempts to develop an animal model of bullous pemphigoid (BP) have failed to result in inflammatory disease in the skin. P1-2 is an 18-amino acid peptide encoded for by the 230-kD BP antigen cDNA that has been shown to contain an epitope recogniz ... Full text Link to item Cite

Expression of cross-reactive idiotypes at the basement membrane zone in patients with bullous pemphigoid.

Journal Article J Invest Dermatol · June 1993 The purpose of the present study was to determine whether tissue-bound anti-basement membrane zone (BMZ) autoantibodies in patients with bullous pemphigoid (BP) express a cross-reactive idiotype. We assayed 34 skin biopsies from 26 patients with BP and nin ... Full text Link to item Cite

Dermatitis herpetiformis.

Journal Article J Invest Dermatol · December 1992 Full text Link to item Cite

Comparison of the intestinal and serum antibody response in patients with dermatitis herpetiformis.

Journal Article Clin Immunol Immunopathol · January 1992 Dermatitis herpetiformis (DH) is an intensely pruritic, blistering skin disease characterized by cutaneous IgA deposits and an associated, most often asymptomatic, gluten-sensitive enteropathy. When patients with DH are placed on a gluten-free diet both th ... Full text Link to item Cite

Vancomycin-associated linear IgA dermatosis. A report of three cases.

Journal Article J Am Acad Dermatol · January 1992 BACKGROUND: Linear IgA dermatosis is an autoantibody-mediated, subepidermal blistering disease that is rarely associated with drug exposure. OBJECTIVE: We report the development of linear IgA dermatosis in three patients associated with the administration ... Full text Link to item Cite

Immunogenetics of dermatitis herpetiformis.

Journal Article Semin Dermatol · September 1991 Dermatitis herpetiformis (DH) is a pruritic, papulovesicular skin disease characterized in part by the presence of granular deposits of IgA at the dermal-epidermal junction, an associated gluten sensitive enteropathy (GSE), and a strong association with sp ... Link to item Cite

Soluble interleukin-2 receptor levels in patients with dermatitis herpetiformis.

Journal Article J Invest Dermatol · September 1991 To determine the role of T-cell activation in dermatitis herpetiformis (DH), soluble IL-2R levels were measured by enzyme-linked immunosorbent assay (ELISA) in the sera of 30 patients with DH. Levels of this shed receptor are considered to be a measure of ... Full text Link to item Cite

DNA sequence analysis and restriction fragment length polymorphism (RFLP) typing of the HLA-DQw2 alleles associated with dermatitis herpetiformis.

Journal Article J Invest Dermatol · August 1991 Dermatitis herpetiformis (DH) is a blistering autoimmune skin disease associated with a 95-100% incidence of the HLA class II antigen HLA-DQw2. Although the precise role of this antigen in the pathogenesis of DH is unclear, one theory proposes that patient ... Full text Link to item Cite

Salt-split human skin substrate for the immunofluorescent screening of serum from patients with cicatricial pemphigoid and a new method of immunoprecipitation with IgA antibodies.

Journal Article J Am Acad Dermatol · June 1991 In patients with cicatricial pemphigoid, immunoglobulins (usually IgG) and complement are deposited within the dermoepidermal junction and are detected by direct immunofluorescent staining of perilesional mucous membrane and/or skin with fluorescein-labele ... Full text Link to item Cite

Detection of cross-reactive idiotypes in the serum of patients with bullous pemphigoid.

Journal Article J Invest Dermatol · June 1991 To further characterize the circulating antibasement membrane zone (antiBMZ) antibodies present in the sera of patients with bullous pemphigoid (BP), we have generated a mouse monoclonal anti-idiotypic antibody (antiId 3-17) specific for an IgG antiBMZ ant ... Full text Link to item Cite

IgA-binding structures in dermatitis herpetiformis skin are independent of elastic-microfibrillar bundles.

Journal Article J Invest Dermatol · January 1991 Dermatitis herpetiformis (DH) is characterized in part by the presence of granular deposits of IgA in the papillary dermis just beneath the dermal-epidermal junction. The nature of the structures to which IgA binds in DH skin, however, has not been clearly ... Full text Link to item Cite

Salt-split human skin substrate for the immunofluorescent screening of serum from patients with cicatricial pemphigoid and a new method of immunoprecipitation with IgA antibodies

Journal Article Journal of the American Academy of Dermatology · 1991 In patients with cicatricial pemphigoid, immunoglobulins (usually IgG) and complement are deposited within the dermoepidermal junction and are detected by direct immunofluorescent staining of perilesional mucous membrane and/or skin with fluorescein-labele ... Cite

IgG antibodies from patients with bullous pemphigoid bind to localized epitopes on synthetic peptides encoded by bullous pemphigoid antigen cDNA.

Journal Article J Immunol · December 1, 1990 Bullous pemphigoid (BP) is an autoimmune blistering disease characterized in part by the presence of tissue-bound and circulating antibodies specific for basement membrane zone proteins, the BP Ag. The purpose of the present study was to determine seroreac ... Link to item Cite

Dermatitis herpetiformis.

Journal Article Dermatol Clin · October 1990 The state of our understanding of the pathogenesis of DH relies on the integration of several key characteristics: (1) a high frequency of the HLA antigens HLA-B8, HLA-DR3, and HLA-DQw2, (2) an associated GSE, (3) the resolution of both the skin lesions an ... Link to item Cite

Serum interleukin-2 receptor responses to immunization.

Journal Article Clin Immunol Immunopathol · October 1990 Serum interleukin-2 receptor (sIL-2R) levels have been used to assess immune activation in inflammatory and infectious illnesses, although the cellular origin of these receptors and the dynamics of their production are not well defined. To investigate the ... Full text Link to item Cite

An HLA class II region restriction fragment length polymorphism (RFLP) in patients with dermatitis herpetiformis: association with HLA-DP phenotype.

Journal Article J Invest Dermatol · August 1990 Dermatitis herpetiformis (DH) is characterized in part by an associated gluten-sensitive enteropathy (GSE), and a strong association with the HLA antigens HLA-A1, -B8, -DR3, and -DQw2, essentially identical to that seen in patients with isolated GSE (celia ... Full text Link to item Cite

Dermatitis herpetiformis in two American blacks: HLA type and clinical characteristics.

Journal Article J Am Acad Dermatol · March 1990 Dermatitis herpetiformis is a rare blistering skin disease characterized in part by granular IgA deposits at the dermoepidermal junction, an associated gluten-sensitive enteropathy, and a strong association with the human histocompatibility leukocyte antig ... Full text Link to item Cite

Alterations in HLA-DP and HLA-DQ antigen frequency in patients with dermatitis herpetiformis.

Journal Article J Invest Dermatol · October 1989 Dermatitis herpetiformis (DH) is associated with a markedly increased frequency of the HLA class II antigens DR3 and DQw2. To investigate a possible role of HLA-DP (or closely associated genes) in the pathogenesis of DH as well as to confirm the previously ... Full text Link to item Cite

Epidermal keratinocytes express the adhesion molecule intercellular adhesion molecule-1 in inflammatory dermatoses.

Journal Article J Invest Dermatol · May 1989 Using indirect immunofluorescence assays on frozen tissue sections of skin from healthy subjects and subjects with inflammatory skin diseases, we found that intercellular adhesion molecule-1 (ICAM-1) was expressed in a cell surface pattern on epidermal ker ... Full text Link to item Cite

Anti-idiotypic antibodies as vaccine candidates. The immune network.

Journal Article Arch Dermatol · February 1989 Antibodies specific for determinants within the variable region of an antibody molecule are known as anti-idiotypic antibodies. Anti-idiotypic antibodies specific for determinants within the antigen binding site of the antibody may mimic the original antig ... Link to item Cite

Phase slips and switching in charge-density-wave transport.

Journal Article Phys Rev B Condens Matter · December 15, 1988 Full text Link to item Cite

Idiotypes, anti-idiotypes, and autoimmunity.

Journal Article J Am Acad Dermatol · September 1988 Over the past two decades it has become clear that the ability of a host to generate antibodies against a wide variety of potential antigens is due to structural diversity in the antibody molecule within the variable region. This diversity results in sites ... Full text Link to item Cite

Characterization of the mucosal immune response to dietary antigens in patients with dermatitis herpetiformis.

Journal Article J Invest Dermatol · May 1988 The association of dermatitis herpetiformis (DH) with granular IgA deposits at the dermal-epidermal junction and a gluten sensitive enteropathy (GSE) suggests that a mucosal immune response may play an important role in the pathogenesis of DH. The degree o ... Full text Link to item Cite

Dietary management of dermatitis herpetiformis.

Journal Article Arch Dermatol · October 1987 Dermatitis herpetiformis (DH) is an extremely itchy, papulovesicular skin disease characterized in part by the presence of IgA at the dermal-epidermal junction. Eighty-five percent to 90% of DH patients have granular deposits of IgA at the dermal-epidermal ... Link to item Cite

IgA immune complexes in patients with dermatitis herpetiformis occur in the absence of IgA rheumatoid factor.

Journal Article J Invest Dermatol · July 1987 Thirty to forty percent of patients with dermatitis herpetiformis (DH) have IgA-containing circulating immune complexes (IgA-CIC); however, the antigenic composition of these complexes as well as the role they play in the pathogenesis of DH are unknown. Th ... Full text Link to item Cite

The pathogenesis of dermatitis herpetiformis: recent advances.

Journal Article J Am Acad Dermatol · June 1987 Over the last two decades a rapid expansion of our knowledge regarding dermatitis herpetiformis has occurred, including the discovery of IgA in the skin, the discovery of an associated gluten-sensitive enteropathy, the noting of an increased prevalence of ... Full text Link to item Cite

Sherwin, Hall, and Zettl respond.

Journal Article Phys Rev Lett · December 30, 1985 Full text Link to item Cite

Characterization of circulating and cutaneous IgA immune complexes in patients with dermatitis herpetiformis.

Journal Article J Immunol · September 1985 Dermatitis herpetiformis (DH) is a chronic, blistering skin disease characterized in part by deposits of IgA at the dermal-epidermal junction. Eighty-five percent of DH patients have granular IgA deposits and have an associated gluten-sensitive enteropathy ... Link to item Cite

Characterization of T lymphocyte and monocyte populations in HLA B8/DRw3 normal individuals and in patients with dermatitis herpetiformis.

Journal Article J Invest Dermatol · March 1984 Normal individuals who possess the HLA B8/DRw3 haplotype as well as patients with dermatitis herpetiformis have been found to have a number of immunologic abnormalities including decreased numbers of E rosette-positive, Fc IgG receptor-bearing lymphocytes ... Full text Link to item Cite

Pruritic urticarial papules and plaques of pregnancy. Clinical experience in twenty-five patients.

Journal Article J Am Acad Dermatol · March 1984 During the past eight years, twenty-five patients with pruritic urticarial papules and plaques of pregnancy (PUPPP) have been prospectively evaluated at our institution. This distinct eruption of the third trimester was most frequently seen in primigravida ... Full text Link to item Cite

IgA-containing immune complexes in patients with psoriatic arthritis.

Journal Article Clin Exp Rheumatol · 1984 Using a sensitive, specific Raji cell radioimmunoassay we have analyzed the sera of 35 patients with psoriatic arthritis (PsA) for IgA-containing circulating immune complexes. In addition, the 125I-Clq binding assay and the Raji IgG radio-immunoassay were ... Link to item Cite

Reticuloendothelial system fc receptor function in rheumatoid arthritis.

Journal Article J Rheumatol · August 1983 Patients with systemic lupus erythematosus (SLE) have abnormal reticuloendothelial system (RES) IgG Fc receptor function which is correlated with disease activity and levels of immune complexes (IC). We studied RES function, IC levels, clinical and laborat ... Link to item Cite

Dietary gluten challenge does not influence the levels of circulating immune complexes in patients with dermatitis herpetiformis.

Journal Article J Invest Dermatol · June 1983 To examine the relationship between the gluten-sensitive enteropathy (GSE) and IgA circulating immune complexes (CIC) in dermatitis herpetiformis (DH) a series of dietary gluten-challenge studies were performed in patients with DH and patients with ordinar ... Full text Link to item Cite

Circulating IgA immune complexes in patients with psoriasis.

Journal Article J Invest Dermatol · June 1983 The sera of 21 patients with psoriasis were examined for the presence of IgA-containing circulating immune complexes (CIC) using the Raji IgA radioimmunoassay. In addition, the Raji IgG radioimmunoassay and 125I-Clq binding assay were used to detect IgG- a ... Full text Link to item Cite

Randomised trial of plasma exchange in mild systemic lupus erythematosus.

Journal Article Lancet · January 1, 1983 The effects of intensive plasma exchange on the serological and clinical manifestations of mildly active systemic lupus erythematosus were evaluated in a controlled, double-blind trial. Twenty patients were randomised to receive either six 4-litre plasma e ... Full text Link to item Cite

IgA-containing circulating immune complexes in patients with igA nephropathy.

Journal Article Am J Med · January 1983 The role of circulating immune complexes in the pathogenesis of IgA nephropathy (Berger's disease) is controversial. Previous studies have shown that a minority of these patients have immune complexes, but the methods used have been able to detect only IgG ... Full text Link to item Cite

Methods for the detection of circulating immune complexes

Journal Article Plasma Therapy and Transfusion Technology · January 1, 1983 Cite

Bullous eruption of systemic lupus erythematosus.

Journal Article J Am Acad Dermatol · December 1982 Full text Link to item Cite

Barriers to medical care of Mexican-Americans: the role of social class, acculturation, and social isolation.

Journal Article Med Care · September 1982 Literature on medical care utilization by Mexican-Americans suggests that patterns of utilization can be explained, in part, by acculturation, social class and social isolation. The relative importance of these variables is explored in a survey of a rural ... Full text Link to item Cite

Monocyte receptors for the Fc portion of IgG studies with monomeric human IgG1: normal in vitro expression of Fc gamma receptors in HLA-B8/Drw3 subjects with defective Fc gamma-mediated in vivo clearance.

Journal Article J Immunol · September 1982 The Fc gamma receptors of reticuloendothelial cells are presumed to play an important role in the clearance of circulating particles opsonized with IgG. In order to quantify these receptors and assess their contribution to the clearance phenomenon in man, ... Link to item Cite

Bullous eruption of systemic lupus erythematosus. Dramatic response to dapsone therapy.

Journal Article Ann Intern Med · August 1982 Four patients with systemic lupus erythematosus developed a nonpruritic vesiculobullous eruption that was unresponsive to high-dose systemic corticosteroid therapy. In three patients the eruption was not associated with a flare of systemic disease. Biopsy ... Full text Link to item Cite

Habitual anger-coping styles: I. Effect on mean blood pressure and risk for essential hypertension.

Journal Article Psychosom Med · May 1982 In this study we examined the effect(s) of race, sex socioecological stress, and habitual anger-coping systolic/diastolic blood pressure levels and risk for being classified hypotensive. A total of 495 black/white males and 511 black/white females, residin ... Full text Link to item Cite

Endocrine activity in air traffic controllers at work. II. Biological, psychological and work correlates.

Journal Article Psychoneuroendocrinology · 1982 This is the second in a series of three papers describing cortisol and growth hormone secretion in air traffic controllers at work. Comparing controllers' average hormone levels across a large number of biological, psychological and occupational characteri ... Full text Link to item Cite

Endocrine activity in air traffic controllers at work. III. Relationship to physical and psychiatric morbidity.

Journal Article Psychoneuroendocrinology · 1982 This final report in the series of three examines the relationships between physical health change, psychopathology and work responsiveness to cortisol and growth hormone secretion in air traffic controllers. In contrast to expectations, those who had the ... Full text Link to item Cite

Endocrine activity in air traffic controllers at work. I. Characterization of cortisol and growth hormone levels during the day.

Journal Article Psychoneuroendocrinology · 1982 This is the first in a series of three reports on repeated endocrine studies in the working environment for a group of 416 air traffic controllers. Twenty-minute integrated concentrations for plasma cortisol and human growth hormone across five-hr work per ... Full text Link to item Cite

Dermal myiasis: the porcine lipid cure.

Journal Article Arch Dermatol · November 1981 Full text Link to item Cite

Erythromelalgia-like eruption in parkinsonian patients treated with bromocriptine.

Journal Article Neurology · October 1981 In a previous report about the chronic use of bromocriptine in Parkinson disease, a distinctive cutaneous eruption was noted and termed "erythromelalgia." This eruption has occurred in 9 of 110 patients on chronic bromocriptine therapy; histopathologic exa ... Full text Link to item Cite

IgA-containing circulating immune complexes in gluten-sensitive enteropathy.

Journal Article Clin Exp Immunol · August 1981 Since mucosal immune response involving IgA may be particularly important in the pathogenesis of gluten-sensitive enteropathy (GSE), we examined the sera of 22 patients with GSE for IgA-containing circulating immune complexes using a sensitive radioimmunoa ... Link to item Cite

Dermatitis herpetiformis.

Journal Article Springer Semin Immunopathol · June 1981 Full text Link to item Cite

Immunopathological and clinical studies in herpes gestationis.

Journal Article Br J Obstet Gynaecol · February 1981 Herpes gestationis is a recurring pruritic, vesiculobullous disease of pregnancy and puerperium. Recently, Lawley et al (1979) reported a high frequency (38 per cent) of fetal morbidity and mortality in 40 cases of immunologically proven herpes gestationis ... Full text Link to item Cite

Defective Fc-receptor functions associated with the HLA-B8/DRw3 haplotype: studies in patients with dermatitis herpetiformis and normal subjects.

Journal Article N Engl J Med · January 22, 1981 Dermatitis herpetiformis is associated with the HLA-B8/DRw3 haplotype in over 90 per cent of patients, and various percentages have been reported to have circulating immune complexes. Since removal of immune complexes from the circulation is thought to dep ... Full text Link to item Cite

Circulating immune complexes in dermatologic disease.

Journal Article Springer Semin Immunopathol · 1981 Full text Link to item Cite

Dermatitis herpetiformis: the skin and the gut.

Journal Article Ann Intern Med · December 1980 Dermatitis herpetiformis is an intensely itchy, chronic, papulovesicular eruption that is usually symmetrically distributed on extensor surfaces. Histologically, it is characterized by dermal papillary collections of neutrophils and subepidermal vesicle fo ... Full text Link to item Cite

IgA-containing circulating immune complexes in dermatitis herpetiformis, Henoch-Schönlein purpura, systemic lupus erythematosus and other diseases.

Journal Article Clin Exp Immunol · June 1980 The sera of patients with dermatitis herpetiformis, Henoch-Schönlein purpura and systemic lupus erythematosus were examined for IgA-containing immune complexes using a newly described radioimmunoassay. The IgG Raji cell radioimmunoassay and the 125I-C1q bi ... Link to item Cite