Scholars@Duke
Stuart Johnston Knechtle

Stuart Johnston Knechtle

William R. Kenan, Jr. Distinguished Professor of Surgery
Surgery, Abdominal Transplant Surgery
Manage Profile
Embed Profile Data

Selected Publications

Acoustofluidic-based therapeutic apheresis system.

Journal Article Nat Commun · August 10, 2024 Therapeutic apheresis aims to selectively remove pathogenic substances, such as antibodies that trigger various symptoms and diseases. Unfortunately, current apheresis devices cannot handle small blood volumes in infants or small animals, hindering the tes ... Full text Link to item Cite

Allosensitisation in NHP results in cross-reactive anti-SLA antibodies not detected by a lymphocyte-based flow cytometry crossmatch.

Journal Article HLA · July 2024 Xenotransplantation is a potential option for individuals for whom an acceptable human allograft is unavailable. Individuals with broadly reactive HLA antibodies due to prior exposure to foreign HLA are potential candidates for a clinical xenotransplant tr ... Full text Link to item Cite

Prolonged xenokidney graft survival in sensitized NHP recipients by expression of multiple human transgenes in a triple knockout pig.

Journal Article Sci Transl Med · June 12, 2024 Genetic modification of porcine donors, combined with optimized immunosuppression, has been shown to improve outcomes of experimental xenotransplant. However, little is known about outcomes in sensitized recipients, a population that could potentially bene ... Full text Link to item Cite

Banff 2022 Liver Group Meeting report: Monitoring long-term allograft health.

Journal Article Am J Transplant · June 2024 The Banff Working Group on Liver Allograft Pathology met in September 2022. Participants included hepatologists, surgeons, pathologists, immunologists, and histocompatibility specialists. Presentations and discussions focused on the evaluation of long-term ... Full text Link to item Cite

A pig kidney supporting human physiology.

Journal Article Kidney Int · May 2024 Because of the global shortage of donor kidneys, xenotransplantation emerges as a potential solution for individuals with kidney failure who face challenges in securing a suitable donor kidney. A study featured in this month's issue of Kidney International ... Full text Link to item Cite

Posoleucel in Kidney Transplant Recipients with BK Viremia: Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial.

Journal Article J Am Soc Nephrol · May 1, 2024 KEY POINTS: Posoleucel was generally safe, well tolerated, and associated with a greater reduction of BK viremia compared with placebo. BK viremia reduction occurred coincident with an increase in the circulating frequency of BK virus–specific T cells in p ... Full text Link to item Cite

The impact of IdeS (imlifidase) on allo-specific, xeno-reactive, and protective antibodies in a sensitized rhesus macaque model.

Journal Article Xenotransplantation · 2024 BACKGROUND: Highly sensitized patients face many barriers to kidney transplantation, including higher rates of antibody-mediated rejection after HLA-incompatible transplant. IdeS, an endopeptidase that cleaves IgG nonspecifically, has been trialed as desen ... Full text Link to item Cite

The T-cell environment: may the regulatory force be with you.

Journal Article Kidney Int · January 2024 In the study by Sasaki et al. in this issue, the authors studied infusions of ex vivo-expanded regulatory T cells in a highly clinically relevant nonhuman primate kidney transplant model. This commentary will aim to discuss the use of regulatory T cells in ... Full text Link to item Cite

Normothermic Machine Perfusion of Donor Livers for Transplantation in the United States: A Randomized Controlled Trial.

Journal Article Ann Surg · November 1, 2023 OBJECTIVE: To compare conventional low-temperature storage of transplant donor livers [static cold storage (SCS)] with storage of the organs at physiological body temperature [normothermic machine perfusion (NMP)]. BACKGROUND: The high success rate of live ... Full text Link to item Cite

Design and testing of a humanized porcine donor for xenotransplantation.

Journal Article Nature · October 2023 Recent human decedent model studies1,2 and compassionate xenograft use3 have explored the promise of porcine organs for human transplantation. To proceed to human studies, a clinically ready porcine donor must be engineered and its xenograft successfully t ... Full text Link to item Cite

Detailed Analysis of Simultaneous Renal and Liver Allografts in the Presence of DSA.

Journal Article Transplant Direct · August 2023 UNLABELLED: Liver allografts protect renal allografts from the same donor from some, but not all, preformed donor specific alloantibodies (DSA). However, the precise mechanisms of protection and the potential for more subtle alterations/injuries within the ... Full text Link to item Cite

Understanding heterogeneity of human bone marrow plasma cell maturation and survival pathways by single-cell analyses.

Journal Article Cell Rep · July 25, 2023 Human bone marrow (BM) plasma cells are heterogeneous, ranging from newly arrived antibody-secreting cells (ASCs) to long-lived plasma cells (LLPCs). We provide single-cell transcriptional resolution of 17,347 BM ASCs from five healthy adults. Fifteen clus ... Full text Link to item Cite

Multicenter Validation of a Urine CXCL10 Assay for Noninvasive Monitoring of Renal Transplants.

Journal Article Transplantation · July 1, 2023 BACKGROUND: Urine CXCL10 (C-X-C motif chemokine ligand 10, interferon gamma-induced protein 10 [IP10]) outperforms standard-of-care monitoring for detecting subclinical and early clinical T-cell-mediated rejection (TCMR) and may advance TCMR therapy develo ... Full text Link to item Cite

Desensitization and belatacept-based maintenance therapy in pregnancy-sensitized monkeys receiving a kidney transplant.

Journal Article Sci Adv · May 19, 2023 Among sensitized patients awaiting a transplant, females are disproportionately represented, partly because of pregnancy-induced sensitization. Using female NHPs sensitized by pregnancy alone, we examined the efficacy of costimulation blockade and proteaso ... Full text Link to item Cite

Daratumumab Use Prior to Kidney Transplant and T Cell-Mediated Rejection: A Case Report.

Journal Article Am J Kidney Dis · May 2023 There is growing interest in daratumumab in the solid organ transplant realm owing to the potential immunomodulatory effects on CD38-expressing cells, primarily plasma cells, as they have a key role in antibody production. In particular there is interest i ... Full text Link to item Cite

Doing it right: Caring for and protecting patient information for US organ donors and transplant recipients.

Journal Article Patterns (N Y) · April 14, 2023 In the current US organ transplantation system, there are no regulations defining how organ procurement organizations must manage personal data and protect the privacy of donors and recipients. In response to the recent announcement of a major overhaul of ... Full text Link to item Cite

Acoustofluidic-based therapeutic apheresis system.

Journal Article Nat Commun · August 10, 2024 Therapeutic apheresis aims to selectively remove pathogenic substances, such as antibodies that trigger various symptoms and diseases. Unfortunately, current apheresis devices cannot handle small blood volumes in infants or small animals, hindering the tes ... Full text Link to item Cite

Allosensitisation in NHP results in cross-reactive anti-SLA antibodies not detected by a lymphocyte-based flow cytometry crossmatch.

Journal Article HLA · July 2024 Xenotransplantation is a potential option for individuals for whom an acceptable human allograft is unavailable. Individuals with broadly reactive HLA antibodies due to prior exposure to foreign HLA are potential candidates for a clinical xenotransplant tr ... Full text Link to item Cite

Prolonged xenokidney graft survival in sensitized NHP recipients by expression of multiple human transgenes in a triple knockout pig.

Journal Article Sci Transl Med · June 12, 2024 Genetic modification of porcine donors, combined with optimized immunosuppression, has been shown to improve outcomes of experimental xenotransplant. However, little is known about outcomes in sensitized recipients, a population that could potentially bene ... Full text Link to item Cite

Banff 2022 Liver Group Meeting report: Monitoring long-term allograft health.

Journal Article Am J Transplant · June 2024 The Banff Working Group on Liver Allograft Pathology met in September 2022. Participants included hepatologists, surgeons, pathologists, immunologists, and histocompatibility specialists. Presentations and discussions focused on the evaluation of long-term ... Full text Link to item Cite

A pig kidney supporting human physiology.

Journal Article Kidney Int · May 2024 Because of the global shortage of donor kidneys, xenotransplantation emerges as a potential solution for individuals with kidney failure who face challenges in securing a suitable donor kidney. A study featured in this month's issue of Kidney International ... Full text Link to item Cite

Posoleucel in Kidney Transplant Recipients with BK Viremia: Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial.

Journal Article J Am Soc Nephrol · May 1, 2024 KEY POINTS: Posoleucel was generally safe, well tolerated, and associated with a greater reduction of BK viremia compared with placebo. BK viremia reduction occurred coincident with an increase in the circulating frequency of BK virus–specific T cells in p ... Full text Link to item Cite

The impact of IdeS (imlifidase) on allo-specific, xeno-reactive, and protective antibodies in a sensitized rhesus macaque model.

Journal Article Xenotransplantation · 2024 BACKGROUND: Highly sensitized patients face many barriers to kidney transplantation, including higher rates of antibody-mediated rejection after HLA-incompatible transplant. IdeS, an endopeptidase that cleaves IgG nonspecifically, has been trialed as desen ... Full text Link to item Cite

The T-cell environment: may the regulatory force be with you.

Journal Article Kidney Int · January 2024 In the study by Sasaki et al. in this issue, the authors studied infusions of ex vivo-expanded regulatory T cells in a highly clinically relevant nonhuman primate kidney transplant model. This commentary will aim to discuss the use of regulatory T cells in ... Full text Link to item Cite

Normothermic Machine Perfusion of Donor Livers for Transplantation in the United States: A Randomized Controlled Trial.

Journal Article Ann Surg · November 1, 2023 OBJECTIVE: To compare conventional low-temperature storage of transplant donor livers [static cold storage (SCS)] with storage of the organs at physiological body temperature [normothermic machine perfusion (NMP)]. BACKGROUND: The high success rate of live ... Full text Link to item Cite

Design and testing of a humanized porcine donor for xenotransplantation.

Journal Article Nature · October 2023 Recent human decedent model studies1,2 and compassionate xenograft use3 have explored the promise of porcine organs for human transplantation. To proceed to human studies, a clinically ready porcine donor must be engineered and its xenograft successfully t ... Full text Link to item Cite

Detailed Analysis of Simultaneous Renal and Liver Allografts in the Presence of DSA.

Journal Article Transplant Direct · August 2023 UNLABELLED: Liver allografts protect renal allografts from the same donor from some, but not all, preformed donor specific alloantibodies (DSA). However, the precise mechanisms of protection and the potential for more subtle alterations/injuries within the ... Full text Link to item Cite

Understanding heterogeneity of human bone marrow plasma cell maturation and survival pathways by single-cell analyses.

Journal Article Cell Rep · July 25, 2023 Human bone marrow (BM) plasma cells are heterogeneous, ranging from newly arrived antibody-secreting cells (ASCs) to long-lived plasma cells (LLPCs). We provide single-cell transcriptional resolution of 17,347 BM ASCs from five healthy adults. Fifteen clus ... Full text Link to item Cite

Multicenter Validation of a Urine CXCL10 Assay for Noninvasive Monitoring of Renal Transplants.

Journal Article Transplantation · July 1, 2023 BACKGROUND: Urine CXCL10 (C-X-C motif chemokine ligand 10, interferon gamma-induced protein 10 [IP10]) outperforms standard-of-care monitoring for detecting subclinical and early clinical T-cell-mediated rejection (TCMR) and may advance TCMR therapy develo ... Full text Link to item Cite

Desensitization and belatacept-based maintenance therapy in pregnancy-sensitized monkeys receiving a kidney transplant.

Journal Article Sci Adv · May 19, 2023 Among sensitized patients awaiting a transplant, females are disproportionately represented, partly because of pregnancy-induced sensitization. Using female NHPs sensitized by pregnancy alone, we examined the efficacy of costimulation blockade and proteaso ... Full text Link to item Cite

Daratumumab Use Prior to Kidney Transplant and T Cell-Mediated Rejection: A Case Report.

Journal Article Am J Kidney Dis · May 2023 There is growing interest in daratumumab in the solid organ transplant realm owing to the potential immunomodulatory effects on CD38-expressing cells, primarily plasma cells, as they have a key role in antibody production. In particular there is interest i ... Full text Link to item Cite

Doing it right: Caring for and protecting patient information for US organ donors and transplant recipients.

Journal Article Patterns (N Y) · April 14, 2023 In the current US organ transplantation system, there are no regulations defining how organ procurement organizations must manage personal data and protect the privacy of donors and recipients. In response to the recent announcement of a major overhaul of ... Full text Link to item Cite

Information design to support growth, quality, and equity of the US transplant system.

Journal Article Am J Transplant · January 2023 The Organ Procurement and Transplantation Network, an arm of the Health Resources and Services Administration, has a contract with the United Network for Organ Sharing since 1986 to provide central oversight of organ donation and transplants in the United ... Full text Link to item Cite

Clinical recommendations for posttransplant assessment of anti-HLA (Human Leukocyte Antigen) donor-specific antibodies: A Sensitization in Transplantation: Assessment of Risk consensus document.

Journal Article Am J Transplant · January 2023 Although anti-HLA (Human Leukocyte Antigen) donor-specific antibodies (DSAs) are commonly measured in clinical practice and their relationship with transplant outcome is well established, clinical recommendations for anti-HLA antibody assessment are sparse ... Full text Link to item Cite

Reimagining the United States organ procurement and transplant network

Journal Article Frontiers in Transplantation · January 1, 2023 The United States system of solid organ transplantation is overseen by the Organ Procurement Transplantation Network (OPTN). Recent announcements from the Health Resources and Services Administration (HRSA) indicate their clear intention to reform the syst ... Full text Cite

Hilliard Seigler, M.D. and the origins of kidney transplantation and immunology at Duke.

Journal Article Front Transplant · 2023 The contributions of Dr. Hilliard Seigler to the founding of the Duke kidney transplantation program were considerable in both surgery and immunology. Some of these highlights are summarized based upon interviews with Dr. Seigler by the authors. ... Full text Link to item Cite

Belatacept and carfilzomib-based treatment for antibody-mediated rejection in a sensitized nonhuman primate kidney transplantation model.

Journal Article Front Transplant · 2023 INTRODUCTION: One-third of HLA-incompatible kidney transplant recipients experience antibody mediated rejection (AMR) with limited treatment options. This study describes a novel treatment strategy for AMR consisting of proteasome inhibition and costimulat ... Full text Link to item Cite

Translation of therapeutic strategies to modulate B cell reponses from non-human primate models to human kidney transplantation.

Journal Article Front Transplant · 2023 Using novel drugs targeting lymphocyte costimulation, cytokines, antibody, complement, and plasma cells, we have developed strategies in a non-human primate model to modulate the B cell response to incompatible kidney transplants. After more than two decad ... Full text Link to item Cite

Belatacept-Based Maintenance Immunosuppression Controls the Post-Transplant Humoral Immune Response in Highly Sensitized Nonhuman Primates.

Journal Article Kidney360 · December 29, 2022 Preexisting donor-specific antibodies (DSA) to MHC antigens increase the risk of antibody-mediated rejection (AMR) in sensitized transplant recipients and reduces graft survival. Pretransplant desensitization with costimulation blockade and proteasome inhi ... Full text Link to item Cite

A novel method for in vitro culture and expansion of nonhuman primate B cells.

Journal Article J Immunol Methods · December 2022 BACKGROUND: Given the role of B cells in sensitization and antibody-mediated rejection pathogenesis, the ability to identify, isolate, and study B cells in vitro is critical for understanding these processes and developing novel therapeutics. While in vivo ... Full text Link to item Cite

Addition of interleukin-6 receptor blockade to carfilzomib-based desensitization in a highly sensitized nonhuman primate model.

Journal Article Am J Transplant · December 2022 Sensitized patients, those who had prior exposure to foreign human leukocyte antigens, are transplanted at lower rates due to challenges in finding suitable organs. Desensitization strategies have permitted highly sensitized patients to undergo kidney tran ... Full text Link to item Cite

Liver Transplantation as a New Standard of Care in Patients With Perihilar Cholangiocarcinoma? Results From an International Benchmark Study.

Journal Article Ann Surg · November 1, 2022 OBJECTIVE: To define benchmark values for liver transplantation (LT) in patients with perihilar cholangiocarcinoma (PHC) enabling unbiased comparisons. BACKGROUND: Transplantation for PHC is used with reluctance in many centers and even contraindicated in ... Full text Link to item Cite

Introducing thymus for promoting transplantation tolerance.

Journal Article J Allergy Clin Immunol · September 2022 Establishing tolerance remains a central, if elusive, goal of transplantation. In solid-organ transplantation, one strategy for inducing tolerance has been cotransplantation of various forms of thymic tissue along with another organ. As one of the biologic ... Full text Link to item Cite

Shifting Clinical Trial Endpoints in Kidney Transplantation: The Rise of Composite Endpoints and Machine Learning to Refine Prognostication.

Journal Article Transplantation · August 1, 2022 The measurement of outcomes in kidney transplantation has been more accurately documented than almost any other surgical procedure result in recent decades. With significant improvements in short- and long-term outcomes related to optimized immunosuppressi ... Full text Link to item Cite

Harnessing the B Cell Response in Kidney Transplantation - Current State and Future Directions.

Journal Article Front Immunol · 2022 Despite dramatic improvement in kidney transplantation outcomes over the last decades due to advent of modern immunosuppressive agents, long-term outcomes remain poor. Antibody-mediated rejection (ABMR), a B cell driven process, accounts for the majority o ... Full text Link to item Cite

Complement-targeted therapies in kidney transplantation-insights from preclinical studies.

Journal Article Front Immunol · 2022 Aberrant activation of the complement system contributes to solid-organ graft dysfunction and failure. In kidney transplantation, the complement system is implicated in the pathogenesis of antibody- and cell-mediated rejection, ischemia-reperfusion injury, ... Full text Link to item Cite

A cell-based multiplex immunoassay platform using fluorescent protein-barcoded reporter cell lines.

Journal Article Commun Biol · November 25, 2021 Multiplex immunoassays with acellular antigens are well-established based on solid-phase platforms such as the Luminex® technology. Cell barcoding by amine-reactive fluorescent dyes enables analogous cell-based multiplex assays, but requires multiple label ... Full text Open Access Link to item Cite

A Historical Cohort in Kidney Transplantation: 55-Year Follow-Up of 72 HLA-Identical, Donor-Recipient Pairs.

Journal Article J Clin Med · November 24, 2021 The impact of HLA matching on graft survival has been well characterized in renal transplantation, with a higher degree of matching associated with superior graft survival. Additionally, living donor grafts are known to confer superior survival compared to ... Full text Link to item Cite

C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates.

Journal Article Nat Commun · September 15, 2021 Sensitized kidney transplant recipients experience high rates of antibody-mediated rejection due to the presence of donor-specific antibodies and immunologic memory. Here we show that transient peri-transplant treatment with the central complement componen ... Full text Link to item Cite

Point-of-Care Assessment of DCD Livers During Normothermic Machine Perfusion in a Nonhuman Primate Model.

Journal Article Hepatol Commun · September 2021 Normothermic machine perfusion (NMP) provides clinicians an opportunity to assess marginal livers before transplantation. However, objective criteria and point-of-care (POC) biomarkers to predict risk and guide decision making are lacking. In this investig ... Full text Link to item Cite

Optical coherence tomography of small intestine allograft biopsies using a handheld surgical probe.

Journal Article J Biomed Opt · September 2021 SIGNIFICANCE: The current gold standard for monitoring small intestinal transplant (IT) rejection is endoscopic visual assessment and biopsy of suspicious lesions; however, these lesions are only superficially visualized by endoscopy. Invasive biopsies pro ... Full text Link to item Cite

Optimal Immunosuppression Strategy in the Sensitized Kidney Transplant Recipient.

Journal Article J Clin Med · August 18, 2021 Patients with previous sensitization events against anti-human leukocyte antigens (HLA) often have circulating anti-HLA antibodies. Following organ transplantation, sensitized patients have higher rates of antibody-mediated rejection (AMR) compared to thos ... Full text Link to item Cite

A Novel Cell-Based Multiplex Immunoassay Platform

Journal Article · May 21, 2021 AbstractWe describe generation of stable, fluorescence-barcoded cell lines suitable for multiplex screening of antibody to membrane proteins. The utility of this cell-based system, capable of a 256-plex cell panel, ... Full text Cite

Definition and Analysis of Textbook Outcome: A Novel Quality Measure in Kidney Transplantation.

Journal Article World J Surg · May 2021 BACKGROUND: "Textbook outcome" (TO) is a novel composite quality measure that encompasses multiple postoperative endpoints, representing the ideal "textbook" hospitalization for complex surgical procedures. We defined TO for kidney transplantation using a ... Full text Link to item Cite

Preoperative carfilzomib and lulizumab based desensitization prolongs graft survival in a sensitized non-human primate model.

Journal Article Kidney Int · January 2021 Sensitized patients are difficult to transplant due to pre-formed anti-donor immunity. We have previously reported successful desensitization using carfilzomib and belatacept in a non-human primate (NHP) model. Here we evaluated selective blockade of the c ... Full text Link to item Cite

Measuring the Impact of Targeting FcRn-Mediated IgG Recycling on Donor-Specific Alloantibodies in a Sensitized NHP Model.

Journal Article Front Immunol · 2021 BACKGROUND: In transplantation, plasmapheresis and IVIg provide the mainstay of treatment directed at reducing or removing circulating donor-specific antibody (DSA), yet both have limitations. We sought to test the efficacy of targeting the IgG recycling m ... Full text Link to item Cite

Emerging New Approaches in Desensitization: Targeted Therapies for HLA Sensitization.

Journal Article Front Immunol · 2021 There is an urgent need for therapeutic interventions for desensitization and antibody-mediated rejection (AMR) in sensitized patients with preformed or de novo donor-specific HLA antibodies (DSA). The risk of AMR and allograft loss in sensitized patients ... Full text Link to item Cite

Allo-Specific Humoral Responses: New Methods for Screening Donor-Specific Antibody and Characterization of HLA-Specific Memory B Cells.

Journal Article Front Immunol · 2021 Antibody-mediated allograft rejection (AMR) causes more kidney transplant failure than any other single cause. AMR is mediated by antibodies recognizing antigens expressed by the graft, and antibodies generated against major histocompatibility complex (MHC ... Full text Open Access Link to item Cite

Donor apoptotic cell-based therapy for effective inhibition of donor-specific memory T and B cells to promote long-term allograft survival in allosensitized recipients.

Journal Article Am J Transplant · October 2020 Allosensitization constitutes a major barrier in transplantation. Preexisting donor-reactive memory T and B cells and preformed donor-specific antibodies (DSAs) have all been implicated in accelerated allograft rejection in sensitized recipients. Here, we ... Full text Open Access Link to item Cite

Textbook Outcomes in Liver Transplantation.

Journal Article World J Surg · October 2020 BACKGROUND: Textbook outcome (TO) is an emerging concept within multiple surgical domains, which represents a novel effort to define a standardized, composite quality benchmark based on multiple postoperative endpoints that represent the ideal "textbook" h ... Full text Link to item Cite

Outcomes in Kidney Transplantation Between Veterans Affairs and Civilian Hospitals: Considerations in the Context of the MISSION Act.

Journal Article Ann Surg · September 1, 2020 OBJECTIVE: We sought to compare kidney transplantation outcomes between Veterans Affairs (VA) and non-VA transplant centers. SUMMARY BACKGROUND DATA: Transplant care at the VA has previously been scrutinized due to geographic and systematic barriers. The r ... Full text Link to item Cite

Cultured thymus tissue implantation promotes donor-specific tolerance to allogeneic heart transplants.

Journal Article JCI Insight · June 4, 2020 Eighty-six infants born without a thymus have been treated with allogeneic cultured thymus tissue implantation (CTTI). These infants, who lack T cells and are profoundly immunodeficient at birth, after CTTI from an unmatched donor develop T cells similar t ... Full text Open Access Link to item Cite

Experimental modeling of desensitization: What have we learned about preventing AMR?

Journal Article Am J Transplant · June 2020 During the past 5 decades, short-term outcomes in kidney transplant have significantly improved, in large part due to reduced rates and severity of acute rejection. Development of better immunosuppressive maintenance agents, as well as new induction therap ... Full text Link to item Cite

Antibody-Mediated Rejection.

Journal Article Am J Transplant · June 2020 Full text Link to item Cite

Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials.

Journal Article Lancet · May 23, 2020 BACKGROUND: Use of cell-based medicinal products (CBMPs) represents a state-of-the-art approach for reducing general immunosuppression in organ transplantation. We tested multiple regulatory CBMPs in kidney transplant trials to establish the safety of regu ... Full text Link to item Cite

Targeting Calcium Release-activated Calcium Channel Is Not Sufficient to Prevent Rejection in Nonhuman Primate Kidney Transplantation.

Journal Article Transplantation · May 2020 BACKGROUND: Calcineurin inhibitors successfully control rejection of transplanted organs but also cause nephrotoxicity. This study, using a rhesus monkey renal transplantation model, sought to determine the applicability of a new immunomodulatory drug inhi ... Full text Link to item Cite

Recommended Treatment for Antibody-mediated Rejection After Kidney Transplantation: The 2019 Expert Consensus From the Transplantion Society Working Group.

Journal Article Transplantation · May 2020 With the development of modern solid-phase assays to detect anti-HLA antibodies and a more precise histological classification, the diagnosis of antibody-mediated rejection (AMR) has become more common and is a major cause of kidney graft loss. Currently, ... Full text Link to item Cite

B cells in transplant tolerance and rejection: friends or foes?

Journal Article Transpl Int · January 2020 Our understanding of the role of B cells in organ transplantation remains incomplete and continues to grow. The majority of research has focused on the detrimental role of antibodies that drive the development of pathogenesis of the transplanted organ. How ... Full text Link to item Cite

The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.

Journal Article J Alzheimers Dis · 2020 BACKGROUND: Perioperative neurocognitive disorders (PND) are common complications in older adults associated with increased 1-year mortality and long-term cognitive decline. One risk factor for worsened long-term postoperative cognitive trajectory is the A ... Full text Open Access Link to item Cite

Antibody-Mediated Graft Rejection in Nonhuman Primate Models: Comparison of Sensitized Allotransplant and Xenotransplant Rejection

Chapter · January 1, 2020 Antibody-mediated rejection (AMR) is a barrier to successful long-term xenograft survival. We compared AMR in kidney xenotransplantation to sensitized kidney allotransplantation in a nonhuman primate model. With conventional CNI-based immunosuppressive mai ... Full text Cite

Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients.

Journal Article J Am Soc Nephrol · December 2019 BACKGROUND: Patients with broad HLA sensitization have poor access to donor organs, high mortality while waiting for kidney transplant, and inferior graft survival. Although desensitization strategies permit transplantation via lowering of donor-specific a ... Full text Link to item Cite

A Propensity-matched Survival Analysis: Do Simultaneous Liver-lung Transplant Recipients Need a Liver?

Conference Transplantation · August 2019 BACKGROUND: There is debate whether simultaneous lung-liver transplant (LLT) long-term outcomes warrant allocation of 2 organs to a single recipient. We hypothesized that LLT recipients would have improved posttransplant survival compared with matched sing ... Full text Link to item Cite

Improvement in Liver Transplant Outcomes From Older Donors: A US National Analysis.

Journal Article Ann Surg · August 2019 OBJECTIVE: To investigate trends in long-term graft and patient outcomes following liver transplantation using grafts from donors ≥60 years old. SUMMARY BACKGROUND DATA: The scarcity of donor livers has led to increased utilization of organs from donors ≥6 ... Full text Link to item Cite

The past, present, and future of costimulation blockade in organ transplantation.

Journal Article Curr Opin Organ Transplant · August 2019 PURPOSE OF REVIEW: Manipulating costimulatory signals has been shown to alter T cell responses and prolong graft survival in solid organ transplantation. Our understanding of and ability to target various costimulation pathways continues to evolve. RECENT ... Full text Link to item Cite

Translational impact of NIH-funded nonhuman primate research in transplantation.

Journal Article Sci Transl Med · July 10, 2019 The National Institutes of Health (NIH) has long supported using nonhuman primate (NHP) models for research on kidney, pancreatic islet, heart, and lung transplantation. The primary purpose of this research has been to develop new treatments for down-modul ... Full text Link to item Cite

Transplant research in nonhuman primates to evaluate clinically relevant immune strategies in organ transplantation.

Journal Article Transplant Rev (Orlando) · July 2019 Research in transplant immunology using non-human primate (NHP) species to evaluate immunologic strategies to prevent rejection and prolong allograft survival has yielded results that have translated successfully into human organ transplant patient managem ... Full text Link to item Cite

Daratumumab in Sensitized Kidney Transplantation: Potentials and Limitations of Experimental and Clinical Use.

Journal Article J Am Soc Nephrol · July 2019 BACKGROUND: Donor-specific antibodies are associated with increased risk of antibody-mediated rejection and decreased allograft survival. Therefore, reducing the risk of these antibodies remains a clinical need in transplantation. Plasma cells are a logica ... Full text Link to item Cite

The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.

Journal Article J Am Geriatr Soc · April 2019 BACKGROUND/OBJECTIVES: Every year, up to 40% of the more than 16 million older Americans who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD) or delirium. Each of these distinct syndromes is associated with decreased quality of ... Full text Open Access Link to item Cite

Dual targeting: Combining costimulation blockade and bortezomib to permit kidney transplantation in sensitized recipients.

Journal Article Am J Transplant · March 2019 Previous evidence suggests that a homeostatic germinal center (GC) response may limit bortezomib desensitization therapy. We evaluated the combination of costimulation blockade with bortezomib in a sensitized non-human primate kidney transplant model. Sens ... Full text Link to item Cite

Toward Long-term Livers.

Journal Article Ann Surg · January 2019 Full text Link to item Cite

Comparison between liver transplantation and resection for hilar cholangiocarcinoma: A systematic review and meta-analysis.

Journal Article PLoS One · 2019 BACKGROUND: Hilar cholangiocarcinoma (hCCA) is a rare and aggressive malignancy with R0 resection being currently the only option for long-term survival. With the improvement in the outcomes of liver transplantation (LT), the indications for LT have expand ... Full text Link to item Cite

Medical evaluation of the living donor

Chapter · January 1, 2019 Living donor kidney transplants constitute between 10% and 50% of annual kidney transplant volume worldwide. This chapter presents the history of living donation through the modern-day approach to living donation, with a focus on evolving paradigms of what ... Full text Cite

Kidney transplantation - Principles and practice

Book · January 1, 2019 Offering practical guidance for all members of the transplant team, Kidney Transplantation, Principles and Practice, 8th Edition, provides the balanced, up-to-date information you need to achieve optimal outcomes for your patients. A global team of interna ... Full text Cite

Results of renal transplantation

Chapter · January 1, 2019 This chapter reviews outcomes of kidney transplantation using data derived from surveillance and registry data from the United States, Europe, Australia and New Zealand, in addition to data from individual transplant center reports and multicenter trial da ... Full text Cite

Improved contemporary outcomes of liver transplantation for pediatric hepatoblastoma and hepatocellular carcinoma.

Journal Article Pediatr Transplant · December 2018 PURPOSE: Improvement in outcomes of LT for pediatric HB and HCC has been reported in small series. We analyzed national outcomes and changes in donor, recipient, and perioperative factors over time that may contribute to survival differences. METHODS: The ... Full text Link to item Cite

Improved survival in simultaneous lung-liver recipients and candidates in the modern era of lung allocation.

Journal Article J Surg Res · November 2018 BACKGROUND: Liver-lung transplantation (LLT) is a rare procedure performed for patients with end-stage liver and lung disease. The lung allocation score (LAS), introduced in 2005, guides lung allocation including those receiving LLT. However, the impact of ... Full text Link to item Cite

Identification and Management of Abdominal Wall Varices in Pregnancy.

Journal Article Obstet Gynecol · October 2018 BACKGROUND: Portal hypertension in pregnancy is associated with elevated risk of variceal hemorrhage. Ectopic varices, those located outside the esophagus or stomach, are rare but have a high risk of associated maternal morbidity or mortality. CASE: A 31-y ... Full text Link to item Cite

The impact of human leukocyte antigen donor and recipient serotyping and matching on liver transplant graft failure in primary sclerosing cholangitis, autoimmune hepatitis, and primary biliary cholangitis.

Journal Article Clin Transplant · October 2018 Human leukocyte antigen (HLA) serotyping is not considered to have significant impact on liver graft survival and does not factor into U.S. organ allocation. Immune-related liver diseases such as primary sclerosing cholangitis (PSC), autoimmune hepatitis ( ... Full text Link to item Cite

Contemporary Strategies and Barriers to Transplantation Tolerance.

Journal Article Transplantation · August 2018 The purpose of this review is to discuss immunologic tolerance as it applies to solid organ transplantation and to identify barriers that hinder the achievement of this long-term goal. First, the definition of tolerance and an introduction of mechanisms by ... Full text Link to item Cite

Sensitization in Transplantation: Assessment of Risk (STAR) 2017 Working Group Meeting Report.

Journal Article Am J Transplant · July 2018 The presence of preexisting (memory) or de novo donor-specific HLA antibodies (DSAs) is a known barrier to successful long-term organ transplantation. Yet, despite the fact that laboratory tools and our understanding of histocompatibility have advanced sig ... Full text Link to item Cite

Innate networking: Thrombotic microangiopathy, the activation of coagulation and complement in the sensitized kidney transplant recipient.

Journal Article Transplant Rev (Orlando) · July 2018 Thrombotic microangiopathy (TMA) is a histological feature of antibody-mediated rejection and has the potential to cause problematic graft dysfunction, particularly for highly sensitized cross-match positive kidney transplant recipients. Prompt recognition ... Full text Link to item Cite

The Volume-outcome Relationship in Deceased Donor Kidney Transplantation and Implications for Regionalization.

Journal Article Ann Surg · June 2018 OBJECTIVE: The aim of this study was to investigate the volume-outcome relationship in kidney transplantation by examining graft and patient outcomes using standardized risk adjustment (observed-to-expected outcomes). A secondary objective was to examine t ... Full text Link to item Cite

Single-Center Long-Term Analysis of Combined Liver-Lung Transplant Outcomes.

Journal Article Transplant Direct · May 2018 BACKGROUND: Combined lung-liver transplantation (LLT) applies 2 technically challenging transplants in 1 patient with severe 2-organ failure. METHODS: Institutional medical records and United Network for Organ Sharing database were queried for patients at ... Full text Open Access Link to item Cite

IL-21 Biased Alemtuzumab Induced Chronic Antibody-Mediated Rejection Is Reversed by LFA-1 Costimulation Blockade.

Journal Article Front Immunol · 2018 Despite its excellent efficacy in controlling T cell mediated acute rejection, lymphocyte depletion may promote a humoral response. While T cell repopulation after depletion has been evaluated in many aspects, the B cell response has not been fully elucida ... Full text Link to item Cite

Neuroendocrine carcinomas of the gallbladder: Lessons learnt from cases at opposite ends of the spectrum.

Journal Article J BUON · 2018 Neuroendocrine tumors are the rarest tumors of gallbladder. The most aggressive variant is neuroendocrine carcinoma which represents about 0.5% of all gallbladder carcinomas and 0.2% of all neuroendocrine tumors. It seems possible that survival rates can b ... Link to item Cite

Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates.

Journal Article Blood Adv · November 14, 2017 The detrimental effects of donor-directed antibodies in sensitized transplant patients remain a difficult immunologic barrier to successful organ transplantation. Antibody removal is often followed by rebound. Proteasome inhibitors (PIs) deplete antibody-p ... Full text Link to item Cite

Elevated HbA1c in donor organs from patients without a diagnosis of diabetes portends worse liver allograft survival.

Journal Article Clin Transplant · September 2017 Recipients of liver allografts from diabetic donors have decreased graft survival. However, limited data exist on the effects of donor HbA1c. We hypothesized that allografts from nondiabetic donors with elevated HbA1c would be associated with decreased sur ... Full text Link to item Cite

Infiltrative Hepatocellular Carcinoma With Portal Vein Tumor Thrombosis Treated With a Single High-Dose Y90 Radioembolization and Subsequent Liver Transplantation Without a Recurrence.

Journal Article Transplant Direct · September 2017 BACKGROUND: Infiltrative hepatocellular carcinoma with macrovascular invasion is a relatively rare presentation and usually fatal disease. METHODS: Both patients exceeded Milan and University of California-San Francisco (UCSF) criteria, and per Barcelona C ... Full text Link to item Cite

Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation.

Journal Article Am J Transplant · August 2017 Early activation of coagulation is an important factor in the initiation of innate immunity, as characterized by thrombotic microangiopathy (TMA). In transplantation, systemic anticoagulation is difficult due to bleeding. A novel "cytotopic" agent, thromba ... Full text Link to item Cite

Humoral Compensation after Bortezomib Treatment of Allosensitized Recipients.

Journal Article J Am Soc Nephrol · July 2017 The efficacy of bortezomib monotherapy in desensitizing kidney transplant candidates with preformed donor-specific antibodies remains unclear. We evaluated the effect of bortezomib on preformed antibodies and upstream components of the B cell response in a ... Full text Link to item Cite

Crosstalk Between T and B Cells in the Germinal Center After Transplantation.

Journal Article Transplantation · April 2017 Crosstalk between B and T cells in transplantation is increasingly recognized as being important in the alloimmune response. T cell activation of B cells occurs by a 3-stage pathway, culminating with costimulation signals. We review the distinct T cell sub ... Full text Link to item Cite

Hypoxia of the growing liver accelerates regeneration.

Journal Article Surgery · March 2017 BACKGROUND: After portal vein ligation of 1 side of the liver, the other side regenerates at a slow rate. This slow growth may be accelerated to rapid growth by adding a transection between the 2 sides, i.e., performing portal vein ligation and parenchymal ... Full text Link to item Cite

Bridging Locoregional Therapy Prolongs Survival in Patients Listed for Liver Transplant with Hepatocellular Carcinoma.

Journal Article Cardiovasc Intervent Radiol · March 2017 BACKGROUND AND AIMS: To evaluate the long-term survival benefit of bridging locoregional therapy (LRT) prior to orthotopic liver transplantation (OLT) in patients with hepatocellular carcinoma (HCC) within Milan criteria. METHODS: Our transplant center reg ... Full text Link to item Cite

2016 Comprehensive Update of the Banff Working Group on Liver Allograft Pathology: Introduction of Antibody-Mediated Rejection.

Journal Article Am J Transplant · October 2016 The Banff Working Group on Liver Allograft Pathology reviewed and discussed literature evidence regarding antibody-mediated liver allograft rejection at the 11th (Paris, France, June 5-10, 2011), 12th (Comandatuba, Brazil, August 19-23, 2013), and 13th (Va ... Full text Link to item Cite

Rapamycin Interferes With Postdepletion Regulatory T Cell Homeostasis and Enhances DSA Formation Corrected by CTLA4-Ig.

Journal Article Am J Transplant · September 2016 Previously, we demonstrated that alemtuzumab induction with rapamycin as sole maintenance therapy is associated with an increased incidence of humoral rejection in human kidney transplant patients. To investigate the role of rapamycin in posttransplant hum ... Full text Open Access Link to item Cite

Regulating T Cell Behavior.

Journal Article Am J Transplant · July 2016 Full text Link to item Cite

Antibody-Mediated Rejection in Sensitized Nonhuman Primates: Modeling Human Biology.

Journal Article Am J Transplant · June 2016 We have established a model of sensitization in nonhuman primates and tested two immunosuppressive regimens. Animals underwent fully mismatched skin transplantation, and donor-specific antibody (DSA) response was monitored by flow cross-match. Sensitized a ... Full text Link to item Cite

Urine Metabolite Profiles Predictive of Human Kidney Allograft Status.

Journal Article J Am Soc Nephrol · February 2016 Noninvasive diagnosis and prognostication of acute cellular rejection in the kidney allograft may help realize the full benefits of kidney transplantation. To investigate whether urine metabolites predict kidney allograft status, we determined levels of 74 ... Full text Link to item Cite

Percutaneous Management of Benign Biliary Strictures with Large-Bore Catheters: Comparison between Patients with and without Orthotopic Liver Transplantation.

Journal Article J Vasc Interv Radiol · February 2016 PURPOSE: To prospectively evaluate stricture resolution and patency rates of benign biliary strictures treated with percutaneous large-bore catheter "stenting" in patients with and without previous orthotopic liver transplantation (OLT) and to compare trea ... Full text Link to item Cite

One Size Does Not Fit All--Regional Variation in the Impact of the Share 35 Liver Allocation Policy.

Journal Article Am J Transplant · January 2016 Allocation policies for liver transplantation underwent significant changes in June 2013 with the introduction of Share 35. We aimed to examine the effect of Share 35 on regional variation in posttransplant outcomes. We examined two patient groups from the ... Full text Link to item Cite

Impact of Leukocyte Function-Associated Antigen-1 Blockade on Endogenous Allospecific T Cells to Multiple Minor Histocompatibility Antigen Mismatched Cardiac Allograft.

Journal Article Transplantation · December 2015 BACKGROUND: Blocking leukocyte function-associated antigen (LFA)-1 in organ transplant recipients prolongs allograft survival. However, the precise mechanisms underlying the therapeutic potential of LFA-1 blockade in preventing chronic rejection are not fu ... Full text Open Access Link to item Cite

Longitudinal studies of a B cell-derived signature of tolerance in renal transplant recipients.

Journal Article Am J Transplant · November 2015 Biomarkers of transplant tolerance would enhance the safety and feasibility of clinical tolerance trials and potentially facilitate management of patients receiving immunosuppression. To this end, we examined blood from spontaneously tolerant renal transpl ... Full text Link to item Cite

Open-label prospective study of the safety and efficacy of glass-based yttrium 90 radioembolization for infiltrative hepatocellular carcinoma with portal vein thrombosis.

Journal Article Cancer · July 1, 2015 BACKGROUND: The safety and efficacy of yttrium 90 ((90) Y) therapy for unresectable infiltrative hepatocellular carcinoma (HCC) with portal vein thrombosis (PVT) requires further evaluation. METHODS: A prospective, single-center safety and feasibility stud ... Full text Link to item Cite

Systems biological analyses reveal the hepatitis C virus (HCV)-specific regulation of hematopoietic development.

Journal Article Hepatology · March 2015 UNLABELLED: Chronic liver disease is characterized by the liver enrichment of myeloid dendritic cells (DCs). To assess the role of disease on myelopoiesis, we utilized a systems biology approach to study development in liver-resident cells expressing stem ... Full text Link to item Cite

Neutralizing BAFF/APRIL with atacicept prevents early DSA formation and AMR development in T cell depletion induced nonhuman primate AMR model.

Journal Article Am J Transplant · March 2015 Depletional strategies directed toward achieving tolerance induction in organ transplantation have been associated with an increased incidence and risk of antibody-mediated rejection (AMR) and graft injury. Our clinical data suggest correlation of increase ... Full text Open Access Link to item Cite

The clinical relevance of alloantibody in liver transplantation.

Journal Article Transplant Rev (Orlando) · January 2015 The transplanted liver appears resistant to antibody-mediated injury compared to other transplanted organs such as kidney or heart. However, a growing number of reports suggest that alloantibody to the liver is associated with poorer outcomes. The data sur ... Full text Link to item Cite

Belatacept: is there BENEFIT for liver transplantation too?

Other Am J Transplant · August 2014 The results of the multicenter belatacept liver transplant trial disappoint with respect to safety and efficacy, and new approaches will be required before this agent plays a role in liver transplant immunosuppression. See article by Klintmalm et al on pag ... Full text Link to item Cite

Laparoscopic vs open right hepatectomy: a value-based analysis.

Journal Article J Am Coll Surg · May 2014 BACKGROUND: Current literature lacks sufficient data on outcomes after extensive laparoscopic liver resections. We hypothesized that laparoscopic right hepatectomy (LRH) is associated with better clinical outcomes and less overall hospital costs than open ... Full text Link to item Cite

Transplant versus resection for the management of hepatocellular carcinoma meeting Milan Criteria in the MELD exception era at a single institution in a UNOS region with short wait times.

Journal Article J Surg Oncol · May 2014 BACKGROUND: Management of hepatocellular carcinoma (HCC) in the Model for End-Stage Liver Disease (MELD) exception era remains regionally variable. Outcomes were compared for patients undergoing transplant versus resection at a single institution in a UNOS ... Full text Link to item Cite

The role of donor-specific HLA alloantibodies in liver transplantation.

Journal Article Am J Transplant · April 2014 The impact of donor-specific HLA alloantibodies (DSA) on short- and long-term liver transplant outcome is not clearly defined. While it is clear that not all levels of allosensitization produce overt clinical injury, and that liver allografts possess some ... Full text Link to item Cite

Banff 2013 meeting report: inclusion of c4d-negative antibody-mediated rejection and antibody-associated arterial lesions.

Conference Am J Transplant · February 2014 The 12th Banff Conference on Allograft Pathology was held in Comandatuba, Brazil, from August 19-23, 2013, and was preceded by a 2-day Latin American Symposium on Transplant Immunobiology and Immunopathology. The meeting was highlighted by the presentation ... Full text Link to item Cite

Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection.

Journal Article Am J Transplant · January 2014 De novo donor-specific antibody (DSA) after organ transplantation promotes antibody-mediated rejection (AMR) and causes late graft loss. Previously, we demonstrated that depletion using anti-CD3 immunotoxin combined with tacrolimus and alefacept (AMR regim ... Full text Open Access Link to item Cite

Racial and socioeconomic disparities in pediatric and young adult liver transplant outcomes.

Journal Article Liver Transpl · January 2014 Racial and socioeconomic disparities exist in liver transplantation (LT) outcomes among adults, but little research exists for pediatric LT populations. We examined racial differences in graft survival and mortality within a retrospective cohort of pediatr ... Full text Link to item Cite

Urine proteomics in kidney transplantation.

Journal Article Transplant Rev (Orlando) · January 2014 The transplanted kidney, through its urinary output, provides a medium through which the molecular constitution can provide insight into either the healthy function or developing dysfunction of a newly transplanted organ. An assay that would detect the abe ... Full text Link to item Cite

Immunosuppression in Transplantation

Chapter · January 1, 2014 The field of soLid organ transplantation has rapidly evolved into the treatment of choice for many end-stage organ illnesses. Much of this evolution is attributable to significantly improved short-term outcomes resulting from successful immunosuppressive t ... Full text Cite

Anti-CD40 ligand monoclonal antibody delays the progression of murine autoimmune cholangitis.

Journal Article Clin Exp Immunol · December 2013 While there have been significant advances in our understanding of the autoimmune responses and the molecular nature of the target autoantigens in primary biliary cirrhosis (PBC), unfortunately these data have yet to be translated into new therapeutic agen ... Full text Link to item Cite

Simultaneous kidney transplantation and bilateral native nephrectomy for polycystic kidney disease.

Journal Article J Urol · December 2013 PURPOSE: Bilateral native nephrectomy with simultaneous kidney transplantation is becoming more common for patients with polycystic kidney disease in the living donor nephrectomy era. Single center reports evaluating the short-term and long-term outcomes o ... Full text Link to item Cite

Humoral Immunity Induced By Viral Infection Provides a Major Barrier To Hematopoietic Cell Transplantation

Conference Blood · November 15, 2013 AbstractBackgroundSensitization to MHC antigens because of transfusion, pregnancy, and previous grafts is among the most critical chal ... Full text Cite

Post-transplant lymphoproliferative disorder associated with immunosuppressive therapy for renal transplantation in rhesus macaques (Macaca mulatta).

Journal Article Exp Toxicol Pathol · November 2013 Human post-transplant lymphoproliferative disorder (PTLD) is an abnormal lymphoid proliferation that arises in 1-12% of transplant recipients as a consequence of prolonged immunosuppression and Epstein-Barr viral infection (EBV). Nonhuman primates, primari ... Full text Link to item Cite

Urinary-cell mRNA profile and acute cellular rejection in kidney allografts.

Journal Article N Engl J Med · July 4, 2013 BACKGROUND: The standard test for the diagnosis of acute rejection in kidney transplants is the renal biopsy. Noninvasive tests would be preferable. METHODS: We prospectively collected 4300 urine specimens from 485 kidney-graft recipients from day 3 throug ... Full text Link to item Cite

Induction immunosuppression in liver transplantation: a review.

Journal Article Transpl Int · July 2013 Antibody therapy for induction is seldom used in liver transplantation in the United States, but continues to be used in approximately 10% of patients. The most commonly used antibody at the current time is basiliximab (Simulect, Novartis) and is used in a ... Full text Link to item Cite

Lymphodepletional strategies in transplantation.

Journal Article Cold Spring Harb Perspect Med · July 1, 2013 Because lymphocytes were shown to mediate transplant rejection, their depletion has been studied as a mechanism of preventing rejection and perhaps inducing immunologic tolerance. Agents that profoundly deplete lymphocytes have included monoclonal antibodi ... Full text Link to item Cite

Evaluation of clinical outcomes of prophylactic versus preemptive cytomegalovirus strategy in liver transplant recipients.

Journal Article Transpl Int · June 2013 Cytomegalovirus (CMV) is a major cause of morbidity and mortality following solid organ transplantation (SOT). Two strategies, prophylactic, and preemptive have emerged for the prevention of CMV infection and disease after SOT. This retrospective chart rev ... Full text Link to item Cite

Reply to Vanhove et al.

Other Transpl Int · April 2013 Full text Link to item Cite

Domino liver transplantation in maple syrup urine disease: a case report and review of the literature.

Journal Article Transplant Proc · March 2013 BACKGROUND: Improved outcomes have expanded the indications for liver transplantation, thus aggravating the already limited supply of donor organs. Domino liver transplantation (DLT) has been one strategy to augment the supply of donor organs in cases of i ... Full text Link to item Cite

Therapeutic effect of cytotoxic T lymphocyte antigen 4/immunoglobulin on a murine model of primary biliary cirrhosis.

Journal Article Hepatology · February 2013 UNLABELLED: Collectively, the data in both humans and murine models of human primary biliary cirrhosis (PBC) suggest that activated T cells, particularly CD8 T cells, play a critical role in biliary cell destruction. Under physiological conditions, T-cell ... Full text Link to item Cite

Identification of potential cytokine pathways for therapeutic intervention in murine primary biliary cirrhosis.

Conference PLoS One · 2013 Primary biliary cirrhosis (PBC) is considered a model autoimmune disease, with the most highly directed and specific autoantibody in both murine and human autoimmunity, the anti-mitochondrial autoantibody (AMA). However, therapeutic advances in this diseas ... Full text Link to item Cite

Kidney transplantation-principles and practice, seventh edition

Journal Article Kidney Transplantation-Principles and Practice, Seventh Edition · January 1, 2013 With meticulous updates throughout, Kidney Transplantation remains your definitive medical resource for state-of-the-art answers on every aspect of renal transplantation. A multidisciplinary approach from internationally renowned nephrologists from around ... Cite

Preface to the seventh edition

Journal Article Kidney Transplantation-Principles and Practice, Seventh Edition · January 1, 2013 Full text Cite

Hepatic enrichment and activation of myeloid dendritic cells during chronic hepatitis C virus infection.

Journal Article Hepatology · December 2012 UNLABELLED: Chronic hepatitis C virus (HCV) infection is a serious disease that can result in numerous long-term complications leading to liver failure or death. Approximately 80% of people fail to clear their infection, largely as the result of weak, narr ... Full text Link to item Cite

The glucagon-like peptide-1 receptor agonist Exendin 4 has a protective role in ischemic injury of lean and steatotic liver by inhibiting cell death and stimulating lipolysis.

Journal Article Am J Pathol · November 2012 Nonalcoholic fatty liver disease is an increasingly prevalent spectrum of conditions characterized by excess fat deposition within hepatocytes. Affected hepatocytes are known to be highly susceptible to ischemic insults, responding to injury with increased ... Full text Link to item Cite

Patterns of de novo allo B cells and antibody formation in chronic cardiac allograft rejection after alemtuzumab treatment.

Journal Article Am J Transplant · October 2012 Even though the etiology of chronic rejection (CR) is multifactorial, donor specific antibody (DSA) is considered to have a causal effect on CR development. Currently the antibody-mediated mechanisms during CR are poorly understood due to lack of proper an ... Full text Open Access Link to item Cite

Enhanced de novo alloantibody and antibody-mediated injury in rhesus macaques.

Journal Article Am J Transplant · September 2012 Chronic allograft rejection is a major impediment to long-term transplant success. Humoral immune responses to alloantigens are a growing clinical problem in transplantation, with mounting evidence associating alloantibodies with the development of chronic ... Full text Open Access Link to item Cite

Biologics in organ transplantation.

Journal Article Transpl Int · July 2012 The last two decades have witnessed a pandemic in antibody development, with over 600 entering clinical studies and a total of 28 approved by the FDA and European Union. The incorporation of biologics in transplantation has made a significant impact on all ... Full text Link to item Cite

Belatacept Prevents De Novo Alloantibody Production in Rhesus Macaques.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · May 1, 2012 Link to item Cite

Enhanced De Novo Alloantibody and Antibody-Mediated Injury in Rhesus Macaques.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · May 1, 2012 Link to item Cite

Phenotypic and Functional Analysis of Long-Lived Alloreactive Plasma Cells.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · May 1, 2012 Link to item Cite

The Role of Alemtuzumab in Solid Organ Transplantation

Chapter · April 19, 2012 National registry data indicate a trend towards increasing use of lymphocyte-depleting antibody induction therapy into immunosuppressive regimens for solid organ transplantation. Depletional induction has been shown to reduce the risk of early acute reject ... Full text Cite

The role of B cells in solid organ transplantation.

Journal Article Semin Immunol · April 2012 The role of antibodies in chronic injury to organ transplants has been suggested for many years, but recently emphasized by new data. We have observed that when immunosuppressive potency decreases either by intentional weaning of maintenance agents or due ... Full text Open Access Link to item Cite

Tolerogenic therapies in transplantation.

Journal Article Front Immunol · 2012 Since the concept of immunologic tolerance was discovered in the 1940s, the pursuit of tolerance induction in human transplantation has led to a rapid development of pharmacologic and biologic agents. Short-term graft survival remains an all-time high, but ... Full text Link to item Cite

Hepatocellular carcinoma lesion characterization: single-institution clinical performance review of multiphase gadolinium-enhanced MR imaging--comparison to prior same-center results after MR systems improvements.

Journal Article Radiology · December 2011 PURPOSE: To measure diagnostic performance in the detection of hepatocellular carcinoma (HCC) by using the most recent technology and multiphase gadolinium-enhanced magnetic resonance (MR) imaging and to compare with earlier results at the same institution ... Full text Link to item Cite

Primary vascularization of the graft determines the immunodominance of murine minor H antigens during organ transplantation.

Journal Article J Immunol · October 15, 2011 Grafts can be rejected even when matched for MHC because of differences in the minor histocompatibility Ags (mH-Ags). H4- and H60-derived epitopes are known as immunodominant mH-Ags in H2(b)-compatible BALB.B to C57BL/6 transplantation settings. Although m ... Full text Open Access Link to item Cite

Liver transplantation for the treatment of hepatocellular carcinoma.

Journal Article Oncology (Williston Park) · July 2011 The rise of infection with hepatitis C virus worldwide and the lack of effective treatment for this infection has led to a rise in the incidence of hepatocellular carcinoma (HCC). Moreover, it is now accepted that the cirrhotic liver, regardless of etiolog ... Link to item Cite

Miles to go….

Other Am J Transplant · June 2011 Full text Link to item Cite

Donor-directed MHC class I antibody is preferentially cleared from sensitized recipients of combined liver/kidney transplants.

Journal Article Am J Transplant · April 2011 For patients with chronic renal and liver diseases, simultaneous liver and kidney transplantation (SLKT) is the best therapeutic option. The role of a pretransplant donor-specific antibody (DSA) in SLKT is unclear. We report the results of a retrospective ... Full text Link to item Cite

A Non-Human Primate Model for Alloantibody Production after T Cell Depletion

Conference AMERICAN JOURNAL OF TRANSPLANTATION · April 1, 2011 Link to item Cite

Immunoregulation and tolerance.

Journal Article Transplant Proc · November 2010 T-regulatory cells (Tregs), a subset of CD4(+)CD25(+) lymphocytes, have the functional ability to suppress alloimmune responses in vitro and in vivo. Conditions that promote their development and enhance their biological function may be attractive for prom ... Full text Link to item Cite

The effectiveness of locoregional therapies versus supportive care in maintaining survival within the Milan criteria in patients with hepatocellular carcinoma.

Journal Article J Vasc Interv Radiol · August 2010 PURPOSE: To compare survival after treatment with either locoregional therapy (LRT) or supportive care in patients with hepatocellular carcinoma (HCC) within the Milan criteria. MATERIALS AND METHODS: Patients with HCC who were classified within the Milan ... Full text Link to item Cite

Cytokine kinetics profiling in pediatric renal transplant recipients.

Journal Article Pediatr Transplant · August 2010 Pediatric renal transplant recipients experience side effects of immunosuppression. Few immunoassays exist which can assess the adequacy of immunosuppression. We developed a CKT, whereby cytokine levels are measured in a five-day mixed lymphocyte reaction. ... Full text Link to item Cite

Interleukin-15 receptor blockade in non-human primate kidney transplantation.

Journal Article Transplantation · April 27, 2010 BACKGROUND: Interleukin (IL)-15 is a chemotactic factor to T cells. It induces proliferation and promotes survival of activated T cells. IL-15 receptor blockade in mouse cardiac and islet allotransplant models has led to long-term engraftment and a regulat ... Full text Open Access Link to item Cite

Prevention trumps treatment of antibody-mediated transplant rejection.

Other J Clin Invest · April 2010 Belying the spectacular success of solid organ transplantation and improvements in immunosuppressive therapy is the reality that long-term graft survival rates remain relatively unchanged, in large part due to chronic and insidious alloantibody-mediated gr ... Full text Open Access Link to item Cite

PARP-1 Mediates Inflammation in Mouse Renal Transplants

Conference AMERICAN JOURNAL OF TRANSPLANTATION · April 1, 2010 Link to item Cite

Transient CD86 expression on hepatitis C virus-specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling.

Journal Article J Immunol · March 1, 2010 Costimulatory signals via B7/CD28 family molecules (signal 2) are critical for effective adaptive CD8(+) T cell immune responses. In addition to costimulatory signals, B7/CD28 family coinhibitory receptor/ligands that modulate immune responses have been id ... Full text Link to item Cite

Infections after the use of alemtuzumab in solid organ transplant recipients: a comparative study.

Journal Article Diagn Microbiol Infect Dis · January 2010 We undertook a retrospective cohort study comparing infection in solid organ transplant recipients receiving alemtuzumab (n = 726) versus basiliximab (n = 215) or antithymocyte globulin (ATG) (n = 85). Eighty-one percent of patients had kidney transplants. ... Full text Link to item Cite

Overcoming Chronic Rejection-Can it B?

Journal Article Transplantation · October 27, 2009 Despite the success of immunosuppressive drug therapy to reduce the incidence of acute rejection in organ transplantation, chronic rejection is still an impediment to long-term graft survival and tolerance. There is a growing body of evidence that B-cell p ... Full text Link to item Cite

Urine osteoprotegerin and monocyte chemoattractant protein-1 in lupus nephritis.

Journal Article J Rheumatol · October 2009 OBJECTIVE: Renal biopsy is the "gold standard" to determine renal activity in systemic lupus erythematosus (SLE), but it is expensive, invasive, and carries risk. Osteoprotegerin (OPG) is produced by the heart, lungs, kidney, and bone. Monocyte chemoattrac ... Full text Link to item Cite

BAFF is increased in renal transplant patients following treatment with alemtuzumab.

Journal Article Am J Transplant · August 2009 Alemtuzumab is a monoclonal antibody that depletes T and B cells and is used as induction therapy for renal transplant recipients. Without long-term calcineurin inhibitor (CNI) therapy, alemtuzumab-treated patients have a propensity to develop alloantibody ... Full text Link to item Cite

Noninvasive detection of acute and chronic injuries in human renal transplant by elevation of multiple cytokines/chemokines in urine.

Journal Article Transplantation · June 27, 2009 BACKGROUND: Injuries in kidney transplant is currently diagnosed by needle biopsy. A noninvasive test that sensitively detects these injuries would benefit the patients. METHODS: Urine samples were collected from healthy controls and kidney transplant reci ... Full text Link to item Cite

Early and limited use of tacrolimus to avoid rejection in an alemtuzumab and sirolimus regimen for kidney transplantation: clinical results and immune monitoring.

Journal Article Am J Transplant · May 2009 Alemtuzumab induction with 60 days of tacrolimus treatment and continuous sirolimus treatment prevented acute rejection in nine of 10 consecutive renal allograft recipients. All patients are alive with a functioning kidney graft at 27-39 months of follow-u ... Full text Link to item Cite

Unique aspects of rejection and tolerance in liver transplantation.

Journal Article Semin Liver Dis · February 2009 Spontaneous acceptance of liver allografts occurs in several species. However, tolerance is rare in human transplant patients even though rejection is relatively easily reversed. Histological features of acute rejection in liver transplantation are similar ... Full text Link to item Cite

Alemtuzumab induction and antibody-mediated kidney rejection after simultaneous pancreas-kidney transplantation.

Journal Article Transplantation · January 15, 2009 BACKGROUND: The best induction agent for simultaneous pancreas-kidney transplantation (SPKT) remains the subject of debate. Alemtuzumab is effective in preventing acute cellular rejection (ACR) in SPK recipients and has been used to prevent antibody-mediat ... Full text Link to item Cite

BAFF Dysregulation in Renal Transplant Patients Treated with Campath-1H

Journal Article AMERICAN JOURNAL OF TRANSPLANTATION · January 1, 2009 Link to item Cite

Vascular access for dialysis, chemotherapy, and nutritional support

Chapter · December 1, 2008 The success of many modern medical therapies is intimately tied to the success of vascular access. Hemodialysis for renal failure, chemotherapy for cancer, hyperalimentation for nutritional support, plasmapheresis for autoimmune disease, central pressure m ... Full text Cite

Kidney transplantation

Chapter · December 1, 2008 In 2002 in the United States, 431,281 patients received treatment for end-stage renal disease (ESRD), including 308,910 on dialysis and 122,374 with a functioning renal transplant.1 The prevalence of ESRD is increasing at an annual rate of 4%, down from 9% ... Full text Cite

Preface to the Sixth Edition

Book · December 1, 2008 Full text Cite

Kidney Transplantation

Book · December 1, 2008 Updated to reflect todays practice guidelines, the new edition of this comprehensive text remains the definitive resource on all aspects of renal transplantation, including immunological, pathological, psychological and ethical considerations. It examines ... Cite

Results of Renal Transplantation

Chapter · December 1, 2008 Full text Cite

Risk factors and outcomes in post-liver transplantation bile duct stones and casts: A case-control study.

Journal Article Liver Transpl · October 2008 Bile duct stones and casts (BDS) after liver transplantation are associated with significant morbidity. Risk factors for BDS formation and the efficacy of treatment in liver transplant recipients have not been systematically studied. The aim of this study ... Full text Link to item Cite

A comparison of alemtuzumab with basiliximab induction in simultaneous pancreas-kidney transplantation.

Journal Article Am J Transplant · August 2008 Alemtuzumab is a humanized, rat monoclonal antibody directed against the CD52 antigen. After binding, alemtuzumab causes profound and durable depletion and has been successfully used as immune induction therapy for organ transplantation. This was a single ... Full text Link to item Cite

Unaltered graft survival and intragraft lymphocytes infiltration in the cardiac allograft of Cxcr3-/- mouse recipients.

Journal Article Am J Transplant · August 2008 Previous studies showed that absence of chemokine receptor Cxcr3 or its blockade prolong mouse cardiac allograft survival. We evaluated the effect of the CXCR3 receptor antagonist MRL-957 on cardiac allograft survival, and also examined the impact of anti- ... Full text Link to item Cite

Calcineurin inhibitor withdrawal after renal transplantation with alemtuzumab: clinical outcomes and effect on T-regulatory cells.

Journal Article Am J Transplant · July 2008 To address the results of calcineurin inhibitor (CNI) withdrawal after alemtuzumab induction relative to CNI continuation, we performed a pilot randomized clinical trial in renal allograft recipients on CNI, a mycophenolic acid derivative and steroids afte ... Full text Link to item Cite

Alemtuzumab induction and triple maintenance immunotherapy in kidney transplantation from donors after cardiac death.

Journal Article Transpl Int · July 2008 We have used alemtuzumab in combination with triple maintenance immunosuppression in renal transplantation from donors after cardiac death between 2002 and 2006. We compared outcomes of induction therapy with alemtuzumab with interleukin-2 (IL-2) receptor ... Full text Link to item Cite

Safety and pharmacokinetics of daclizumab in pediatric renal transplant recipients.

Journal Article Pediatr Transplant · June 2008 This study examined the safety and pharmacokinetics/pharmacodynamics of daclizumab in combination with mycophenolate mofetil (or azathioprine), corticosteroids, and cyclosporine or tacrolimus, in 61 pediatric renal allograft recipients in three age groups: ... Full text Link to item Cite

Kidney Transplantation: Principles and Practice

Book · May 21, 2008 Updated to reflect today's practice guidelines, the new edition of this comprehensive text remains the definitive resource on all aspects of renal transplantation, including immunological, pathological, psychological and ethical considerations. It examines ... Full text Cite

Mechanisms of differential T cell immunodominance in organ transplantation.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · May 1, 2008 Link to item Cite

Cytokine kinetic profiling in children after renal transplantation

Conference AMERICAN JOURNAL OF TRANSPLANTATION · May 1, 2008 Link to item Cite

Campath-1H augments the generation of allo-specific T regulatory cells in vitro

Conference AMERICAN JOURNAL OF TRANSPLANTATION · May 1, 2008 Link to item Cite

Antibody-mediated rejection of the kidney after simultaneous pancreas-kidney transplantation.

Journal Article J Am Soc Nephrol · April 2008 The prevalence, risk factors, and outcome of antibody-mediated rejection (AMR) of the kidney after simultaneous pancreas-kidney transplantation are unknown. In 136 simultaneous pancreas-kidney recipients who were followed for an average of 3.1 yr, 21 episo ... Full text Link to item Cite

CD4+ CD25+ FOXP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H.

Journal Article Am J Transplant · April 2008 Campath-1H (Alemtuzumab) is an effective immunodepletion agent used in renal transplantation. To evaluate its influence on T lymphocytes during repletion, we analyzed peripheral blood from Campath-1H-treated renal allograft recipients for the presence of F ... Full text Link to item Cite

Surgical invention and commercialization.

Journal Article Surgery · February 2008 Full text Link to item Cite

Nonhuman primate infections after organ transplantation.

Journal Article ILAR J · 2008 Nonhuman primates, primarily rhesus macaques (Macaca mulatta), cynomolgus macaques (Macaca fascicularis), and baboons (Papio spp.), have been used extensively in research models of solid organ transplantation, mainly because the nonhuman primate (NHP) immu ... Full text Link to item Cite

The impact of donor variables on the outcome of orthotopic liver transplantation for hepatitis C.

Journal Article Transplant Proc · 2008 Morphologic characteristics of the graft have been proposed as a major contributor to the long-term outcomes in orthotopic liver transplantation (OLT). Our objective was to determine the impact of donor variables, including donor age, donor-recipient HLA m ... Full text Link to item Cite

Macrophages driven to a novel state of activation have anti-inflammatory properties in mice.

Journal Article J Immunol · January 1, 2008 Recurrent episodes of inflammation underlie numerous pathologies, notably those of inflammatory bowel diseases. In this study, we describe a population of macrophages in a novel state of activation that mitigates colitis in mice. The cells responsible for ... Full text Link to item Cite

Altered distribution of H60 minor H antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3-/- mouse recipients.

Journal Article J Immunol · December 15, 2007 Chemokine-chemokine receptor interactions and the subsequent recruitment of T lymphocytes to the graft are believed to be among the initial events in the development of acute and chronic rejection of heart transplants. We sought to determine the role of ch ... Full text Link to item Cite

Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: relevance to mechanism of heart allograft tolerance.

Journal Article J Immunol · November 15, 2007 We hypothesize that developmental exposure to noninherited maternal Ags (NIMA) results in alloantigen-specific natural and adaptive T regulatory (T(R)) cells. We compared offspring exposed to maternal H-2(d) (NIMA(d)) with nonexposed controls. In vitro ass ... Full text Link to item Cite

Dissociation of depletional induction and posttransplant lymphoproliferative disease in kidney recipients treated with alemtuzumab.

Journal Article Am J Transplant · November 2007 Transplant patients are at the risk for posttransplant lymphoproliferative disease (PTLD), a virally-driven malignancy. Induction with the depleting antibody preparations Thymoglobulin and OKT3 is associated with PTLD suggesting that the T-cell depletion i ... Full text Link to item Cite

Liver transplantation in pediatric patients: twenty years of experience at the University of Wisconsin.

Journal Article Pediatr Transplant · September 2007 Developments in surgical technique, immunosuppression, organ procurement and preservation, and patient selection criteria have resulted in improved long-term patient and graft survival after pediatric liver transplantation. In this study, we examined the r ... Full text Link to item Cite

Late graft loss or death in pediatric liver transplantation: an analysis of the SPLIT database.

Other Am J Transplant · September 2007 Late graft loss (LGL) and late mortality (LM) following liver transplantation (LT) in children were analyzed from the studies of pediatric liver transplantation (SPLIT) database. Univariate and multivariate associations between pre- and postoperative facto ... Full text Link to item Cite

Impact of graft type on outcome in pediatric liver transplantation: a report From Studies of Pediatric Liver Transplantation (SPLIT).

Other Ann Surg · August 2007 OBJECTIVE: To examine the outcome of technical variant liver transplant techniques relative to whole organ liver transplantation in pediatric liver transplant recipients. BACKGROUND: Technical variant liver transplant techniques comprising split, reduced, ... Full text Link to item Cite

Alemtuzumab induction and recurrence of glomerular disease after kidney transplantation.

Journal Article Transplantation · June 15, 2007 BACKGROUND: An increase in the incidence of autoimmune diseases has been described in patients receiving alemtuzumab. METHODS: To determine whether induction with alemtuzumab increases recurrence of glomerular disease, we performed a retrospective study in ... Full text Link to item Cite

CXCR3-mediated T-cell chemotaxis involves ZAP-70 and is regulated by signalling through the T-cell receptor.

Journal Article Immunology · April 2007 The chemokine receptor CXCR3 is critical for the function of activated T cells. We studied the molecular mechanisms of CXCR3 signalling. The addition of CXCR3 ligands to normal human T cells expressing CXCR3 led to the tyrosine phosphorylation of multiple ... Full text Link to item Cite

Human CD4+CD25low adaptive T regulatory cells suppress delayed-type hypersensitivity during transplant tolerance.

Journal Article J Immunol · March 15, 2007 Adaptive T regulatory (T(R)) cells mediate the suppression of donor-specific, delayed-type hypersensitivity (DTH) in tolerant organ transplant recipients. We hypothesized that cells belonging to the CD4(+)CD25(+) T cell subset but distinct from natural T(R ... Full text Link to item Cite

Review: chemokines in transplantation

Journal Article Transplantation Reviews · January 1, 2007 The alloimmune response in solid organ transplantation is characterized by antigen presentation, activation of the recipient's immune system, and an effector response. Chemokines are chemotactic cytokines and play a role in all 3 components of the alloimmu ... Full text Cite

Outcomes at 3 years of a prospective pilot study of Campath-1H and sirolimus immunosuppression for renal transplantation.

Journal Article Transpl Int · November 2006 Campath-1H (alemtuzumab) induction was used for renal transplantation in combination with sirolimus as immunosuppression. We previously reported a high (28%) rate of early rejection with this regimen, and now report 3-year outcomes. Twenty-nine patients we ... Full text Link to item Cite

The evolving role of alemtuzumab (Campath-1H) for immunosuppressive therapy in organ transplantation.

Journal Article Transpl Int · September 2006 Alemtuzumab is a monoclonal anti-CD52 antibody, which has been used extensively off label in solid organ transplantation. Its primary use has been as an induction agent at the time of organ transplantation, although there is limited experience using it to ... Full text Link to item Cite

A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppression.

Journal Article Am J Transplant · May 2006 Activated T cells orchestrate the immune response that results in graft rejection; therefore, a common goal among current immunosuppressive therapies is to block T-cell activation, proliferation and function. Current immunosuppressive regimens that inhibit ... Full text Link to item Cite

Determination of the functional status of alloreactive T cells by interferon-gamma kinetics.

Journal Article Transplantation · February 27, 2006 BACKGROUND: A fundamental limitation of in vitro immunologic tests in the field of transplantation is that existing functional tests poorly correlate with in vivo immune responses such as rejection, tolerance, or absence of rejection due to immunosuppressi ... Full text Link to item Cite

The Art and Science of Immunosuppression: the Fifth Annual American Society of Transplant Surgeon's State-of-the-Art Winter Symposium.

Conference Am J Transplant · February 2006 The 2005 American Society of Transplant Surgeons (ASTS) Winter Symposium entitled 'The Art and Science of Immunosuppression' explored ways to maximize existing immunosuppressive protocols and to develop new strategies incorporating novel agents and emergin ... Full text Link to item Cite

T-lymphocyte alloresponses of Campath-1H-treated kidney transplant patients.

Journal Article Transplantation · January 15, 2006 BACKGROUND: Kidney transplant patients given Campath-1H (Alemtuzumab) immunodepletion therapy and long-term rapamycin monotherapy have excellent graft survival and function at three years. As an initial step in understanding the characteristics of repopula ... Full text Link to item Cite

Elevation of multiple cytokines/chemokines in urine of human renal transplant recipients with acute and chronic injuries: potential usage for diagnosis and monitoring

Journal Article Transplantation Reviews · January 1, 2006 Early diagnosis and intervention of acute dysfunction caused by both immune and nonimmune factors in the kidney transplant are crucial for the long-term well-being of the recipient. The monitoring and diagnosis of acute dysfunction and chronic allograft ne ... Full text Cite

Immunosuppression in nonhuman primates

Journal Article Transplantation Reviews · January 1, 2006 Nonhuman primate organ transplant models have been and continue to be an excellent conduit for the development of immunosuppressive therapies for use in human organ transplantation. These experimental therapies often make use of immunosuppressive drugs cur ... Full text Cite

Simultaneous pancreas-kidney transplantation from donation after cardiac death: successful long-term outcomes.

Journal Article Ann Surg · November 2005 OBJECTIVE: The outcomes of simultaneous pancreas-kidney (SPK) transplantation with donor organs procured from donation after cardiac death (DCD) are compared with transplants performed with donor organs recovered from donation after brain death (DBD). SUMM ... Full text Link to item Cite

Donation after cardiac death: the University of Wisconsin experience with liver transplantation.

Journal Article Ann Surg · November 2005 OBJECTIVE: To determine whether the outcomes of liver transplantation (LTx) from donation after cardiac death (DCD) donors are equivalent to those from donation after brain death (DBD) donors. SUMMARY BACKGROUND DATA: Because of the significant donor organ ... Full text Link to item Cite

Development of tolerogenic strategies in the clinic.

Journal Article Philos Trans R Soc Lond B Biol Sci · September 29, 2005 The study of tolerance in the clinic can be divided into three areas: (i) focused evaluation of existing tolerant transplant recipients as to their mechanism of tolerance; (ii) prospective tolerance trials, such as combined bone marrow and kidney transplan ... Full text Link to item Cite

Campath-1H use in pediatric renal transplantation.

Journal Article Am J Transplant · June 2005 Campath-1H is a humanized, monoclonal antibody directed against CD52 determinants on the surface of human B- and T-cells and monocytes. Reports of Campath-1H use as induction in adult renal transplantation have been encouraging with low rejection rates and ... Full text Link to item Cite

Generation of monocyte-derived cells that reduce autoimmune disease in mice

Conference AMERICAN JOURNAL OF TRANSPLANTATION · May 1, 2005 Link to item Cite

Three-year success of Campath-1H induction for renal transplantation.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · May 1, 2005 Link to item Cite

Liver transplantation for HELLP syndrome.

Journal Article Liver Transpl · February 2005 Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome is a rare complication of pregnancy that is associated with preeclampsia and may result in rupture of the liver. Although there have been case reports of liver transplantation for H ... Full text Link to item Cite

Selenium-binding protein-1 in smooth muscle cells is downregulated in a rhesus monkey model of chronic allograft nephropathy.

Journal Article Am J Transplant · January 2005 Treating patients with kidney failure by organ transplantation has been extraordinarily successful. Although, current immunosuppressants have improved short-term allograft survival, most transplants are eventually lost due to chronic allograft nephropathy ... Full text Link to item Cite

Editorial introductions

Other Current Opinion in Organ Transplantation · December 1, 2004 Cite

Surveillance of acute rejection in baboon renal transplantation by elevation of interferon-gamma inducible protein-10 and monokine induced by interferon-gamma in urine.

Journal Article Transplantation · October 15, 2004 BACKGROUND: CXCR3 binding chemokines play a key role in recruitment of inflammatory cells into an organ transplant. This study addresses the question of whether urinary excretion of these chemokines correlates with acute rejection in a baboon kidney transp ... Full text Link to item Cite

Campath-1H in renal transplantation: The University of Wisconsin experience.

Journal Article Surgery · October 2004 BACKGROUND: Immune cell depletion is known to prevent renal allograft rejection and injury. We evaluated the humanized monoclonal antibody Campath-1H (alemtuzumab; ILEX Oncology, San Antonio, Texas) in renal transplant recipients for its safety and efficac ... Full text Link to item Cite

Correlation between human leukocyte antigen antibody production and serum creatinine in patients receiving sirolimus monotherapy after Campath-1H induction.

Journal Article Transplantation · September 27, 2004 BACKGROUND: In this study, we determined whether Campath-1H induction followed by sirolimus monotherapy inhibited alloantibody production in renal transplantation. Second, we evaluated the correlation between human leukocyte antigen (HLA) antibody producti ... Full text Link to item Cite

Donation after cardiac death: the university of wisconsin experience with renal transplantation.

Journal Article Am J Transplant · September 2004 Owing to the shortage of organ donors, there is renewed interest in donation after cardiac death (DCD), formerly referred to as nonheart-beating donation. From January 1984 until August 2000, 382 renal transplants were performed from DCD donors. These were ... Full text Link to item Cite

Infected bilomas in liver transplant recipients: clinical features, optimal management, and risk factors for mortality.

Journal Article Clin Infect Dis · August 15, 2004 BACKGROUND: Infected hepatic fluid collections (bilomas) are a major infectious complication of liver transplantation. Limited data exist on management and outcome of biloma. METHODS: We report a cohort study of 57 liver transplant recipients with posttran ... Full text Link to item Cite

Liver transplantation for biliary atresia: 19-year, single-center experience.

Journal Article Exp Clin Transplant · June 2004 OBJECTIVES: In this study, we describe our 19-year experience with liver transplantation as the definitive treatment for congenital biliary atresia. MATERIALS AND METHODS: We performed a retrospective study of 115 liver transplants from 1984 to 2003 in 85 ... Link to item Cite

Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates.

Journal Article J Immunol · May 1, 2004 Approaches that prevent acute rejection of renal transplants in a rhesus monkey model were studied to determine a common mechanism of acceptance. After withdrawal of immunosuppression, all 14 monkeys retained normal allograft function for >6 mo. Of these, ... Full text Link to item Cite

Present experience with Campath-1H in organ transplantation and its potential use in pediatric recipients.

Journal Article Pediatr Transplant · April 2004 Campath-1H is a humanized monoclonal antibody directed at CD52 expressed on lymphocytes and other cells of the immune system. It has been tested extensively in lymphoid malignancies, autoimmune diseases including rheumatoid arthritis, multiple sclerosis, a ... Full text Link to item Cite

Infected bilomas in liver transplant recipients, incidence, risk factors and implications for prevention.

Journal Article Am J Transplant · April 2004 Bilomas, infected hepatic fluid collections, are a frequent complication of liver transplantation. We report a case-control cohort study to determine the incidence and microbiologic profile of bilomas and risk factors for biloma formation in 492 patients u ... Full text Link to item Cite

Monotherapy with the novel human anti-CD154 monoclonal antibody ABI793 in rhesus monkey renal transplantation model.

Journal Article Transplantation · March 27, 2004 BACKGROUND: This study assesses the safety and efficacy of the novel human anti-human CD154 monoclonal antibody ABI793 in rhesus monkeys. METHODS: Outbred rhesus monkeys were used for renal transplantation from major histocompatibility complex-mismatched d ... Full text Link to item Cite

Metastable tolerance in nonhuman primates and humans.

Journal Article Transplantation · March 27, 2004 It is clear that both humans and nonhuman primates can do without immunosuppression for long periods of time before rejecting their allogeneic organ transplants. Immune cell depletion, particularly lymphocyte depletion, is an effective clinical strategy fo ... Full text Link to item Cite

Elevation of CXCR3-binding chemokines in urine indicates acute renal-allograft dysfunction.

Journal Article Am J Transplant · March 2004 A noninvasive urinary test that diagnoses acute renal allograft dysfunction would benefit renal transplant patients. We aimed to develop a rapid urinary diagnostic test by detecting chemokines. Seventy-three patients with renal allograft dysfunction prompt ... Full text Link to item Cite

Donation after cardiac death: the University of Wisconsin experience.

Journal Article Ann Transplant · 2004 OBJECTIVES: The objective of this analysis was to compare the results of transplantation of livers, pancreases, kidneys, and lungs from donation after cardiac death (DCD) donors to organs transplanted from donation after brain death (DBD) donors. METHODS: ... Link to item Cite

Immune status assay (ISA): a noninvasive procedure for studying allograft rejection.

Journal Article Transpl Immunol · 2004 BACKGROUND: There is a need for a simple, sensitive, noninvasive technique for monitoring graft function. We report here on a simple assay called immune status assay (ISA) that determines the status of the graft by simply examining the activation status of ... Full text Link to item Cite

Editorial

Other Transplantation Reviews · January 1, 2004 Full text Cite

Editorial

Other Transplantation Reviews · January 1, 2004 Full text Cite

Hepatic steatosis and liver transplantation

Journal Article Current Opinion in Organ Transplantation · January 1, 2004 As researchers continue to examine practices in both deceased and living related liver transplantation, there are several animal studies that can provide insight into the mechanisms of injury and offer possible strategies to use such organs in the future. ... Full text Cite

Is steroid avoidance beneficial in kidney transplantation?

Conference AMERICAN JOURNAL OF TRANSPLANTATION · January 1, 2004 Link to item Cite

Clinical trials: where are we now?

Journal Article Immunol Rev · December 2003 Clinical trials in transplantation have focused on improving outcomes and minimizing side effects associated with renal transplantation. Although immunologic tolerance, which means complete freedom from immunosuppressive drugs and maintenance of excellent ... Full text Link to item Cite

Portal hypertension: from Eck's fistula to TIPS.

Journal Article Ann Surg · December 2003 The treatment options for portal hypertension have expanded greatly in the past 2 decades. More selective use of surgical shunts, improvement in pharmacologic therapy, development of endoscopic variceal ligation, and the maturing of liver transplantation u ... Full text Link to item Cite

Rapamycin antagonizes cyclosporin A- and tacrolimus (FK506)-mediated augmentation of linker for activation of T cell expression in T cells.

Journal Article Int Immunol · November 2003 The discovery of new immunosuppressive drugs such as rapamycin, cyclosporin A (CsA) and tacrolimus (FK506) has been very useful for preventing graft rejection and autoimmune disease. However, these drugs are not specific, and are associated with side-effec ... Full text Link to item Cite

Immunotoxin-treated rhesus monkeys: a model for renal allograft chronic rejection.

Journal Article Transplantation · August 15, 2003 BACKGROUND: Unlike acute and hyperacute rejection, chronic rejection (CR) still constitutes a poorly understood process. The onset is insidious, occurs in a period of months to years and, because the pathophysiology is not well understood, is untreatable. ... Full text Link to item Cite

Campath-1H induction plus rapamycin monotherapy for renal transplantation: results of a pilot study.

Journal Article Am J Transplant · June 2003 Campath-1H, an anti-CD52 monoclonal antibody, was used as induction therapy (40 mg i.v. total dose) in 29 primary human renal transplants, and the patients were maintained on rapamycin monotherapy (levels 8-15 ng/mL) post-transplant. Campath-1H profoundly ... Full text Link to item Cite

Chronic allograft nephropathy uniformly affects recipients of cadaveric, nonidentical living-related, and living-unrelated grafts.

Journal Article Transplantation · May 27, 2003 BACKGROUND: Chronic allograft nephropathy (CAN) remains a major barrier to long-term allograft survival. The authors retrospectively compared the development of CAN in recipients of cadaveric (CAD), living-related donor (LRD), and living-unrelated donor (L ... Full text Link to item Cite

Sirolimus monotherapy following Campath-1H induction.

Journal Article Transplant Proc · May 2003 Sirolimus was used as a single agent for maintenance immunosuppression in a pilot trial of 29 primary kidney transplant patients using lymphocyte depletion with Campath-1H as an induction strategy. This allowed sirolimus to be analyzed (dose, blood level, ... Full text Link to item Cite

Underutilization of pancreas donors.

Journal Article Transplantation · April 27, 2003 BACKGROUND: Transplantation of the pancreas has become the treatment of choice for selected patients with type 1 diabetes mellitus. With the current shortage of cadaver donors and the increasing number of diabetic patients on the transplant waiting list, t ... Full text Link to item Cite

Effect of immunosuppressants on T-cell subsets observed in vivo using carboxy-fluorescein diacetate succinimidyl ester labeling.

Journal Article Transplantation · April 15, 2003 BACKGROUND: The in vivo effects of immunosuppressants on T cells are classically determined using animal models of organ transplantation. These methods are technically difficult and time consuming. A simple in vivo method is needed for screening new immuno ... Full text Link to item Cite

Conclusion

Other Transplantation Reviews · January 1, 2003 Full text Cite

Long-term outcomes in simultaneous pancreas-kidney transplantation: lessons relearned.

Journal Article Clin Transpl · 2003 We analyzed 752 simultaneous pancreas kidney transplants performed at the University of Wisconsin from December 1985-February 2003. Patient survival rates at 5 and 10 years were 88% and 77%. The 5- and 10-year pancreas survival rates were 78% and 61% and t ... Link to item Cite

Editorial

Journal Article Transplantation Reviews · January 1, 2003 Full text Cite

A new beginning

Other Transplantation Reviews · January 1, 2003 Full text Cite

An overview of the actions of cyclosporine and FK506

Journal Article Transplantation Reviews · January 1, 2003 Cyclosporine and FK506 are immunosuppressive drugs that have been extremely useful for treating graft-versus-host disease and autoimmune and inflammatory diseases, and they have truly revolutionized allograft transplantation. These drugs exert at least som ... Full text Cite

Mycophenolate mofetil: What is the evidence that it decreases chronic rejection?

Journal Article Current Opinion in Organ Transplantation · January 1, 2003 summary, it is unclear at this time whether MMF has a direct salutary or deleterious effect on CAN in human renal transplantation. © 2003 Lippincott Williams & Wilkins. ... Full text Cite

Novel agents or strategies for immunosuppression after renal transplantation

Journal Article Current Opinion in Organ Transplantation · January 1, 2003 There have been several recent advances in the use of immunosuppression after organ transplantation. The main goal is to induce transplantation tolerance without immunosuppressive drug toxicity. We reviewed both experimental and clinical organ transplantat ... Full text Cite

Portal hypertension: from Eck's fistula to TIPS.

Journal Article Annals of surgery · 2003 The treatment options for portal hypertension have expanded greatly in the past 2 decades. More selective use of surgical shunts, improvement in pharmacologic therapy, development of endoscopic variceal ligation, and the maturing of liver transplantation u ... Cite

Piceatannol in combination with low doses of cyclosporine A prolongs kidney allograft survival in a stringent rat transplantation model.

Journal Article Transplantation · December 15, 2002 BACKGROUND: The discovery of new immunosuppressive agents has enhanced short-term graft survival. However, current immunosuppressants often induce toxicities that limit their clinical use. Thus, there is a need for new immunosuppressants for use in clinica ... Full text Link to item Cite

Novel immunosuppressive agents in tolerance induction.

Journal Article Curr Drug Targets Cardiovasc Haematol Disord · December 2002 Induction of transplantation tolerance remains a much sought-after but elusive goal with a potential promise of rendering patients free of long-term immunosuppressive drugs while maintaining good organ transplant function indefinitely. All currently studie ... Full text Link to item Cite

Liver transplantation at the University of Wisconsin.

Journal Article Clin Transpl · 2002 Liver transplantation remains the only definitive therapy for patients with decompensated liver disease. Significant advances over the past 20 years in surgical technique, immunosuppressive agents, patient selection, and infection prophylaxis and treatment ... Link to item Cite

Tolerance and near-tolerance strategies in monkeys and their application to human renal transplantation.

Journal Article Immunol Rev · October 2001 Studies in non-human primates to evaluate tolerance strategies in organ transplantation have led to innovation in human transplantation. The two strategies we have studied in detail in non-human primates are T-cell depletion by anti-CD3 immunotoxin and co- ... Full text Link to item Cite

Successful conversion from conventional immunosuppression to anti-CD154 monoclonal antibody costimulatory molecule blockade in rhesus renal allograft recipients.

Journal Article Transplantation · August 27, 2001 BACKGROUND: Several conventional forms of immunosuppression have been shown to antagonize the efficacy of anti-CD154 monoclonal antibody- (mAb) based costimulatory molecule blockade immunotherapy. Our objective was to determine if allograft recipients trea ... Full text Link to item Cite

Graft survival in a rhesus renal transplant model after immunotoxin-mediated T-cell depletion is enhanced by mycophenolate and steroids.

Journal Article Transplantation · August 27, 2001 BACKGROUND: Anti-CD3 immunotoxin (IT), a T-cell-depleting agent, prolongs survival of renal allografts in a rhesus monkey model without the need for long-term immunosuppression. In this study we sought to further prolong allograft survival by giving short- ... Full text Link to item Cite

Immunotoxin FN18-CRM9 induces stronger T cell signaling than unconjugated monoclonal antibody FN18.

Journal Article Transplantation · August 15, 2001 BACKGROUND: The T-cell receptor (TCR)/CD3 complex is the target of therapeutic strategies aimed at prolonging allograft survival. The immunotoxin FN18-CRM9, composed of the anti-CD3 monoclonal antibody FN18 and the mutated diphtheria toxin CRM9, is useful ... Full text Link to item Cite

Studies of Pediatric Liver Transplantation (SPLIT): year 2000 outcomes.

Journal Article Transplantation · August 15, 2001 BACKGROUND: Initiated in 1995, the Studies of Pediatric Liver Transplantation (SPLIT) registry database is a cooperative research network of pediatric transplantation centers in the United States and Canada. The primary objectives are to characterize and f ... Full text Link to item Cite

Treatment with immunotoxin.

Journal Article Philos Trans R Soc Lond B Biol Sci · May 29, 2001 T-cell depletion prior to or beginning at the time of transplantation has been shown to be a valuable adjunct to the induction of immunological unresponsiveness. Both total lymphoid irradiation and anti-lymphocyte globulin have been used for this purpose i ... Full text Link to item Cite

What's new in transplantation.

Journal Article J Am Coll Surg · March 2001 Full text Link to item Cite

Living-unrelated renal transplantation at the University of Wisconsin.

Journal Article Clin Transpl · 2001 Since 1984, we have performed 243 living-unrelated renal transplants at the University of Wisconsin. Rejection occurred in 47% of the patients. Graft loss occurred in 59 patients and 39 patients died. Graft survival in LURD transplants at 10 years is 54% a ... Link to item Cite

Analysis of tumor characteristics and survival in liver transplant recipients with incidentally diagnosed hepatocellular carcinoma.

Journal Article J Gastrointest Surg · 2001 The use of orthotopic liver transplantation (OLTX) for the treatment of hepatocellular carcinoma (HCC) has generally become restricted to carefully selected cases of small oligocentric tumors. However, it is not uncommon to find previously undetected HCC w ... Full text Link to item Cite

Liver transplantation from controlled non-heart-beating donors.

Journal Article Surgery · October 2000 BACKGROUND: The use of organs from non-heart-beating donors (NHBDs) has been proposed as one way to increase the donor pool. However, few centers have transplanted livers from NHBDs. We report here the results of 19 liver transplants from controlled NHBDs. ... Full text Link to item Cite

Knowledge about transplantation tolerance gained in primates.

Journal Article Curr Opin Immunol · October 2000 Research in transplantation tolerance relies on application of successful strategies in a nonhuman-primate organ transplant model for preclinical testing. Three principal approaches are being evaluated: hematopoietic chimerism, lymphocyte depletion and cos ... Full text Link to item Cite

Increased glomerular deposits of von Willebrand factor in chronic, but not acute, rejection of primate renal allografts.

Journal Article Transplantation · September 27, 2000 BACKGROUND: In our previously described primate renal allograft model, T cell ablation leads to long-term graft survival. The role of endothelial cell alteration in chronic rejection was examined in our model. METHODS: Renal transplants were performed in r ... Full text Link to item Cite

Long-term results of liver transplantation in older patients 60 years of age and older.

Journal Article Transplantation · September 15, 2000 BACKGROUND: Advances in perioperative care and immunosuppression have enabled clinicians to broaden the indications for organ transplantation. Advanced age is no longer considered a contraindication to transplantation at most centers. Although short-term s ... Full text Link to item Cite

T-cell depletion as a means of achieving tolerance

Journal Article Current Opinion in Organ Transplantation · June 2000 Full text Cite

Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506.

Journal Article Blood · May 1, 2000 The activation of blood cells, including T cells, triggers intracellular signals that control the expression of critical molecules, including cytokines and cytokine receptors. We show that T-cell receptor (TCR) ligation increases the cellular level of the ... Link to item Cite

Primate allotransplantation using costimulation blockade.

Journal Article TRANSPLANTATION · April 27, 2000 Link to item Cite

Simultaneous pancreas-kidney transplantation and living related donor renal transplantation in patients with diabetes: is there a difference in survival?

Journal Article Ann Surg · March 2000 OBJECTIVE: To compare the outcome of simultaneous pancreas-kidney transplantation (SPK) and living related donor renal transplantation (LRD) in patients with diabetes. SUMMARY BACKGROUND DATA: It remains unanswered whether diabetic patients with end-stage ... Full text Link to item Cite

CD40:CD154 interactions and allograft rejection

Journal Article Current Opinion in Organ Transplantation · March 2000 Full text Cite

Regulation of T cell receptor- and CD28-induced tyrosine phosphorylation of the focal adhesion tyrosine kinases Pyk2 and Fak by protein kinase C. A role for protein tyrosine phosphatases.

Journal Article J Biol Chem · January 14, 2000 The T cell receptor (TCR)-CD3 complex and the costimulatory molecule CD28 are critical for T cell function. Both receptors utilize protein tyrosine kinases (PTKs) for the phosphorylation of various signaling molecules, a process that is critical for the fu ... Full text Link to item Cite

Simultaneous pancreas-kidney (SPK) transplantation from controlled non-heart-beating donors (NHBDs).

Journal Article Cell Transplant · 2000 From January 1993 through June 1999, 18 simultaneous pancreas-kidney transplants (SPKs) were performed from controlled non-heart-beating donors (NHBDs) and 339 SPKs were performed from heart-beating donors (HBDs). No difference in donor characteristics was ... Full text Link to item Cite

T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+.

Journal Article J Immunol · December 15, 1999 T cell activation initiates signals that control gene expression of molecules important for T cell function. The focal adhesion kinase Pyk2 has been implicated in T cell signaling. To further analyze the involvement of Pyk2 in T cell processes, we examined ... Link to item Cite

Disseminated aspergillosis involving the brain: distribution and imaging characteristics.

Journal Article AJNR Am J Neuroradiol · October 1999 BACKGROUND AND PURPOSE: Systemic invasive aspergillosis involves the brain through hematogenous dissemination. A retrospective review of 18 patients with aspergillosis involving the brain was performed in order to present imaging findings and thereby broad ... Link to item Cite

Surgical portosystemic shunts for treatment of portal hypertensive bleeding: outcome and effect on liver function.

Journal Article Surgery · October 1999 BACKGROUND: Since the advent of liver transplantation and transjugular intrahepatic portosystemic shunts (TIPS), the role of surgical portosystemic shunts in the treatment of portal hypertension has changed. However, we have continued to use portosystemic ... Link to item Cite

Activation of T lymphocytes for adhesion and cytokine expression by toxin-conjugated anti-CD3 monoclonal antibodies.

Journal Article Transplantation · September 15, 1999 BACKGROUND: Immunosuppressive drugs that target T cells are useful for prolonging allograft survival. The anti-CD3 immunotoxin FN18-CRM9 has been shown to effectively prolong renal allograft survival in a rhesus monkey model of transplantation. However, im ... Full text Link to item Cite

Peripheral vascular disease and renal transplant artery stenosis: a reappraisal of transplant renovascular disease.

Journal Article Clin Transplant · August 1999 BACKGROUND: Renal transplant artery stenosis (RTAS) continues to be a problematic, but potentially correctable, cause of post-transplant hypertension and graft dysfunction. Older transplant recipients, prone to peripheral vascular disease (PVD), may have p ... Full text Link to item Cite

The impact of hypoalbuminemia in kidney-pancreas transplant recipients.

Journal Article Transplantation · July 15, 1999 BACKGROUND: Hypoalbuminemia is associated with poorer outcomes in renal transplantation. Diabetes can compound hypoalbuminemia's detrimental effects. Kidney-pancreas transplantation alters the diabetic milieu; yet, some patients continue to be hypoalbumine ... Full text Link to item Cite

CD28 ligation induces rapid tyrosine phosphorylation of the linker molecule LAT in the absence of Syk and ZAP-70 tyrosine phosphorylation.

Journal Article Eur J Immunol · July 1999 CD28 is a T cell surface molecule that is important for T cell activation. CD28-triggered T cell stimulation involves protein tyrosine phosphorylation, a process that is critical for CD28 function. Recently, a linker molecule has been identified as LAT (Li ... Full text Link to item Cite

Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates.

Journal Article Nat Med · June 1999 CD154 is the ligand for the receptor CD40. This ligand-receptor pair mediates endothelial and antigen-presenting cell activation, and facilitates the interaction of these cells with T cells and platelets. We demonstrate here that administration of a CD154- ... Full text Link to item Cite

Iliac artery pseudoaneurysm following renal transplantation presenting as lumbosacral plexopathy.

Journal Article Transplantation · April 15, 1999 A renal transplant patient developed chronic and progressive back and lower extremity pain followed by foot weakness. The correct diagnosis of lumbosacral plexopathy was made after electromyography and nerve conduction studies and the etiology of radiculop ... Full text Link to item Cite

CD28 ligation induces tyrosine phosphorylation of Pyk2 but not Fak in Jurkat T cells.

Journal Article J Biol Chem · March 5, 1999 Protein tyrosine kinases are critical for the function of CD28 in T cells. We examined whether the tyrosine kinases Pyk2 and Fak (members of the focal adhesion kinase family) are involved in CD28 signaling. We found that ligating CD28 in Jurkat T cells rap ... Full text Link to item Cite

Pancreas transplantation at the University of Wisconsin.

Journal Article Clin Transpl · 1999 Based on the University of Wisconsin experience with 653 cadaver pancreas transplant performed since 1985, we noted that: 1. The overall 5- and 10-year patient survival rates were 87% and 80%, respectively. The 5- and 10-year pancreas graft survival rates ... Link to item Cite

Current management of esophageal variceal bleeding.

Journal Article Adv Surg · 1999 Recent trends in the clinical management of bleeding esophageal varices include a shift away from endoscopic variceal sclerotherapy toward endoscopic variceal ligation. The excellent efficacy of the latter and its lower complication rate favor its increase ... Link to item Cite

A study comparing mycophenolate mofetil to azathioprine in simultaneous pancreas-kidney transplantation.

Journal Article Transplantation · December 27, 1998 BACKGROUND: Mycophenolate mofetil (MMF; Cell-Cept) is a potent and selective inhibitor of B and T lymphocyte proliferation that has proven effective in reducing the incidence of acute rejection in cadaveric kidney transplant recipients in several randomize ... Full text Link to item Cite

Posttransplant infection in enteric versus bladder-drained simultaneous pancreas-kidney transplant recipients.

Journal Article Transplantation · December 27, 1998 BACKGROUND: Although bladder drainage of the pancreas remains the most common site for drainage of exocrine secretions, enteric drainage is becoming more common in the United States. The most common cause of morbidity after pancreas transplantation is infe ... Full text Link to item Cite

Liver transplantation as definitive therapy for complications after arterial embolization for hepatic manifestations of hereditary hemorrhagic telangiectasia.

Journal Article Liver Transpl Surg · November 1998 Experience with hepatic artery embolization for the treatment of symptomatic hepatic arteriovenous malformations (AVMs) in Rendu-Osler-Weber disease is limited. We report 2 cases of hepatic AVMs that caused mesenteric angina-like symptoms that were treated ... Full text Link to item Cite

Strategies for tolerance induction in nonhuman primates.

Journal Article Curr Opin Immunol · October 1998 Organ transplants in nonhuman primates provide a model which closely simulates the biological conditions of human organ transplantation, due to similarities between human and primate MHC (class I and II) structure and expression. Several strategies for tol ... Full text Link to item Cite

Living unrelated renal donation: the University of Wisconsin experience.

Journal Article Surgery · October 1998 BACKGROUND: Living unrelated renal donation (LURD) has the potential to reduce the current waiting list significantly for kidney transplantation. The purpose of this study was to examine the long-term results of 150 LURDs performed at our center during a 1 ... Full text Link to item Cite

Modulation of alloimmunity to major histocompatibility complex class I by cotransfer of cytokine genes in vivo.

Journal Article Transpl Immunol · September 1998 Major histocompatibility complex (MHC) class I antigen is a potent stimulus for alloimmune responses and is the principal immunologic target mediating acute cellular rejection of allografts. Using a method of direct in vivo gene transfer of cDNA encoding d ... Full text Link to item Cite

Experience with 500 simultaneous pancreas-kidney transplants.

Journal Article Ann Surg · September 1998 METHODS: From December 1985 to October 1997, 500 simultaneous pancreas-kidney transplants (SPKs) were performed at the University of Wisconsin. Bladder drainage (BD) was used in 388 and enteric drainage (ED) in 112. All pancreas transplants were preserved ... Full text Link to item Cite

Primate renal transplants using immunotoxin.

Journal Article Surgery · August 1998 BACKGROUND: T-lymphocyte depletion 7 days before transplantation with immunotoxin FN 18-CRM9 has resulted in tolerance to subsequent renal allografts. We tested the effect of giving immunotoxin on the day of the transplantation and evaluated its effect on ... Link to item Cite

Results of the double-blind, randomized, multicenter, phase III clinical trial of Thymoglobulin versus Atgam in the treatment of acute graft rejection episodes after renal transplantation.

Journal Article Transplantation · July 15, 1998 BACKGROUND: Thymoglobulin, a rabbit anti-human thymocyte globulin, was compared with Atgam, a horse anti-human thymocyte globulin for the treatment of acute rejection after renal transplantation. METHODS: A multicenter, double-blind, randomized trial with ... Full text Link to item Cite

Analysis of primate renal allografts after T-cell depletion with anti-CD3-CRM9.

Journal Article Transplantation · July 15, 1998 BACKGROUND: FN18-CRM9 is a CD3-specific immunotoxin that is capable of depleting CD3+ T cells. Pretreatment of rhesus monkeys with this agent before transplantation can induce donor-specific tolerance and "split tolerance" to renal allografts. METHODS: Het ... Full text Link to item Cite

Immunologic suppression mediated by genetically modified hepatocytes expressing secreted allo-MHC class I molecules.

Journal Article Hum Immunol · July 1998 Studies suggest that immunosuppression associated with liver transplantation may be related to the secretion of MHC class I antigen (Ag) by hepatocytes. To investigate this possibility, we developed a culture system whereby naive Lewis (RT1.A1) splenocytes ... Full text Link to item Cite

Rejection of the liver transplant.

Journal Article Semin Gastrointest Dis · July 1998 Although the transplanted human liver is susceptible to rejection with a similar incidence of rejection as seen with renal allografts, the liver enjoys many immunological benefits relative to other transplanted organs. These include relative resistance to ... Link to item Cite

Two distinct forms of soluble MHC class I molecules synthesized by different mechanisms in normal rat cells in vitro.

Journal Article Hum Immunol · July 1998 Rat soluble MHC class I synthesis was studied at both RNA and protein levels to determine whether multiple forms of soluble MHC class I molecules are produced by different mechanisms. RT-PCR and sequencing of MHC class I transcripts identified an alternati ... Full text Link to item Cite

Activation of T cells by toxin-conjugated anti-CD3 antibodies

Conference FASEB Journal · March 20, 1998 Toxin-conjugated anti-CD3 antibodies have been shown to markedly prolong allograft survival in monkeys. Because these antibodies are directed to the anti-CD3 domain of the T cell receptor, it is possible that these antibodies could activate T cells before ... Cite

Donor factors affecting outcome after pancreas transplantation.

Journal Article Transplant Proc · March 1998 In this study, we demonstrated that Px grafts from donors older than 45 years are associated with an increased risk of developing poor glycemic control and premature loss of Px function. Previous studies corroborate our finding that age of the donor is the ... Full text Link to item Cite

Procurement, preservation, and transport of cadaver kidneys.

Journal Article Surg Clin North Am · February 1998 This article discusses the guidelines for brain death determination, the criteria for donor selection, the management of the cadaveric donor, the surgical techniques of isolated renal and multiorgan retrieval, methods of organ preservation, and proper tran ... Full text Link to item Cite

Infant pediatric liver transplantation results equal those for older pediatric patients.

Journal Article J Pediatr Surg · January 1998 METHODS: From July 1984 to July 1995, 99 pediatric patients underwent 127 orthotopic liver transplants (OLT) at the University of Wisconsin Children's Hospital. The patients were divided into four groups according to age at time of transplant: group I, 0 t ... Full text Link to item Cite

Immunotoxins in organ transplantation

Journal Article Current Opinion in Organ Transplantation · October 1997 Full text Cite

Portacaval shunts for ascites: Another perspective (vol 184, pg 650, 1997)

Other JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS · September 1, 1997 Link to item Cite

CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates.

Journal Article Proc Natl Acad Sci U S A · August 5, 1997 Selective inhibition of T cell costimulation using the B7-specific fusion protein CTLA4-Ig has been shown to induce long-term allograft survival in rodents. Antibodies preventing the interaction between CD40 and its T cell-based ligand CD154 (CD40L) have b ... Full text Link to item Cite

Direct MHC class I complementary DNA transfer to thymus induces donor-specific unresponsiveness, which involves multiple immunologic mechanisms.

Journal Article J Immunol · July 1, 1997 Our purposes were 1) to determine whether direct transfer of cDNA encoding allogeneic MHC class I Ag to the rat thymus would be capable of inducing donor-specific unresponsiveness and 2) to study the immunologic mechanism of this effect. Plasmid DNA encodi ... Link to item Cite

Clostridial infection of a liver transplant treated with retransplantation.

Journal Article Clin Transplant · June 1997 Clostridial infection of a liver transplant is reported and was treated successfully with immediate retransplantation and antibiotics. This strategy may salvage patients who otherwise have a fulminant course and certain death. This case supports the genera ... Link to item Cite

Split tolerance induced by immunotoxin in a rhesus kidney allograft model.

Journal Article Transplantation · May 15, 1997 BACKGROUND: Renal allografts were performed in rhesus monkeys using FN18-CRM9, a potent immunotoxin capable of depleting T cells to less than 1% of baseline levels in blood and lymph nodes, as a preparative agent. We have recently reported that animals pre ... Full text Link to item Cite

High efficiency gene transfer to liver with naked DNA.

Conference GASTROENTEROLOGY · April 1, 1997 Link to item Cite

Increased beta 2-microglobulin (B2M) is useful in the detection of post-transplant lymphoproliferative disease (PTLD).

Journal Article Clin Transplant · February 1997 This study examines whether changes in beta 2-microglobulin (B2M) serum levels are useful in the early detection of post-transplant lymphoproliferative disease (PTLD). Serum B2M is monitored daily post-transplant at our center as a marker of change in lymp ... Link to item Cite

FN18-CRM9 immunotoxin promotes tolerance in primate renal allografts.

Journal Article Transplantation · January 15, 1997 BACKGROUND: Transplant tolerance, rather than immunity, may be favored in the setting of a lower mature lymphoid mass in the recipient induced by anti-T cell agents. A novel immunosuppressive agent, FN18-CRM9, known to specifically kill T cells with great ... Full text Link to item Cite

Identification of new mamu-DRB alleles using DGGE and direct sequencing.

Journal Article Immunogenetics · 1997 Rhesus macaques represent important animal models for biomedical research. The ability to identify macaque major histocompatibility complex (Mhc) alleles is crucial for fully understanding these models of autoimmune and infectious disease. Here we describe ... Full text Link to item Cite

Single-center experience with renal transplantation in patients with Wegener's granulomatosis.

Journal Article Transpl Int · 1997 Between 1980 and 1995, 13 patients with end-stage renal disease due to Wegener's granulomatosis received 14 renal transplants (10 cadaveric, 4 living related). The mean follow-up in the 13 successfully transplanted patients was 50 months (4-107 months). On ... Full text Link to item Cite

Emergency portacaval shunts: is Orloff correct?

Journal Article HPB Surg · 1997 A prospective randomized trial was conducted in unselected, consecutive pateints with bleeding esophageal varices resulting from cirrhosis comparing (1) emergency portacaval shunt performed within 8 hr of initial contact (21 patients) with (2) emergency me ... Full text Link to item Cite

Advances in pancreas transplantation: the University of Wisconsin experience.

Journal Article Clin Transpl · 1997 The data show that with careful surgical technique, modern immunosuppression with MMF and FK506, and pancreatic allograft biopsy, it should be possible to achieve: 1) a low rate of technical complications, 2) improved long-term graft survival, particularly ... Link to item Cite

Clinical hepatitis after transplantation of hepatitis C virus-positive kidneys: HLA-DR3 as a risk factor for the development of posttransplant hepatitis.

Journal Article Transplantation · December 27, 1996 BACKGROUND: Exposure to hepatitis C virus (HCV) and subsequent infection after renal transplantation lead to significant clinical hepatitis in approximately 50% of graft recipients. METHODS: One hundred thirty-two consecutive renal allotransplant patients, ... Full text Link to item Cite

Gene therapy in transplantation.

Journal Article Transpl Immunol · December 1996 Full text Link to item Cite

Foot problems in the diabetic transplant recipient.

Journal Article Clin Transplant · December 1996 Diabetic transplant recipients are at a high risk for foot pathology leading to amputation. This retrospective study from 1/85 to 2/95 examines the risk of foot complications in a population (n = 340) of diabetic renal and combined renal/pancreas transplan ... Link to item Cite

Gene therapy and transplantation--a brief review.

Journal Article Transplant Proc · December 1996 Link to item Cite

Impact of improving immunosuppressive treatment on outcome in cadaveric kidney transplantation.

Journal Article Surgery · October 1996 BACKGROUND: Since the advent of cyclosporine-based immunosuppression for cadaveric kidney transplants in 1983, several changes have been made in immunosuppressive management at the University of Wisconsin. Since 1986, OKT3 has been available to treat stero ... Full text Link to item Cite

Revascularization of the solitary kidney: a challenging problem in a high risk population.

Journal Article Surgery · October 1996 BACKGROUND: Patients with significant atherosclerotic stenosis involving the artery to a solitary functioning kidney present a clinical challenge. METHODS: From August 1987 through August 1995, 35 of these patients (average age, 68.4 +/- 6.9 years) were tr ... Full text Link to item Cite

Naked DNA delivered intraportally expresses efficiently in hepatocytes.

Journal Article Gene Ther · July 1996 Naked plasmid DNA in hypertonic solutions was injected intraportally in mice whose hepatic veins were transiently occluded. High levels of luciferase expression and beta-galactosidase expression in 1% of the hepatocytes throughout the entire liver were ach ... Link to item Cite

Adenovirus-mediated gene transfer into rat cardiac allografts. Comparison of direct injection and perfusion.

Journal Article Transplantation · June 27, 1996 With the ultimate goal of modulating the host immune response in organ transplantation, gene therapy studies have demonstrated that direct plasmid DNA injection into transplanted myocardium can result in detectable levels of transgene expression. However, ... Full text Link to item Cite

Determinants of graft survival after renal transplantation.

Journal Article Transplantation · June 15, 1996 We studied multiple determinants of graft survival at a single center and the effects of nonimmunologic graft loss on transplant survival. This retrospective study examined the results of 589 cadaver donor transplants performed between 1986 and 1992. Graft ... Full text Link to item Cite

Preliminary experience with split liver transplantation.

Journal Article J Am Coll Surg · May 1996 BACKGROUND: The purpose of split liver transplantation is to alleviate the organ shortage for patients with end-stage liver disease. The procedure, however, has not gained wide acceptance. This is related not only to the complexity of the procedure but als ... Link to item Cite

Immunosuppressive effects of an HLA class I-derived peptide in a rat cardiac allograft model.

Journal Article Transplantation · April 27, 1996 B7.75-84, a 10-amino-acid peptide derived from the HLA-B7 molecule, prolongs rat heterotopic cardiac allograft survival time (GST) when used with cyclosporine in the Lewis-to-ACI strain combination. We evaluated the ability of B7.75-84 to prolong GST in ot ... Full text Link to item Cite

Radiation therapy for renal transplant rejection refractory to pulse steroids and OKT3.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 1996 PURPOSE: To determine the response rate and kidney graft survival following local irradiation to the transplanted renal graft undergoing persistent rejection after medical management including pulse steroids and OKT3. The role of radiation for renal transp ... Full text Link to item Cite

Risk factors for renal allograft loss in patients with systemic lupus erythematosus.

Journal Article Kidney Int · February 1996 Controversy exists regarding the risk factors for renal allograft loss in patients with systemic lupus erythematosus (SLE). This study is a retrospective evaluation of each of these independent risk factors in 80 renal transplants for ESRD secondary to SLE ... Full text Link to item Cite

The influence of native nephrectomy on the incidence of recurrent disease following renal transplantation for primary glomerulonephritis.

Journal Article Transplantation · January 27, 1996 Factors influencing the incidence of recurrent glomerulonephritis following renal transplantation are poorly understood. Bilateral pretransplant native nephrectomy has been advocated to reduce the likelihood of recurrence after renal transplant. However, t ... Full text Link to item Cite

Pretransplant status and patient survival following liver transplantation.

Journal Article Transplantation · November 15, 1995 The current liver allocation system has been criticized, since available organs go to those who are the most critically ill. These recipients have the poorest overall survival. Identification of pretransplant risk factors for mortality would allow better a ... Link to item Cite

Relationships between sclerosing cholangitis, inflammatory bowel disease, and cancer in patients undergoing liver transplantation.

Journal Article Surgery · October 1995 BACKGROUND: Liver transplantation has emerged as the definitive treatment for primary sclerosing cholangitis (PSC). Its relationships to inflammatory bowel disease and cholangiocarcinoma were evaluated in this series. METHODS: Fifty-three liver transplanta ... Full text Link to item Cite

Living related and unrelated donors for kidney transplantation. A 28-year experience.

Journal Article Ann Surg · September 1995 OBJECTIVE: The objective of this study was to analyze a single center's 28-year experience with 1000 living donor transplants. SUMMARY BACKGROUND DATA: The number of potential renal transplant recipients far exceeds the number of cadaveric donors. For this ... Full text Link to item Cite

Successful extrarenal transplantation from non-heart-beating donors.

Journal Article Transplantation · April 15, 1995 The current organ shortage has made utilization of organs from less-than-ideal donors more common. Although several transplant centers use kidneys from non-heart-beating donors (NHBDs), there has been reluctance to extend the use of these donors to extrare ... Full text Link to item Cite

Obesity as a risk factor following renal transplantation.

Journal Article Transplantation · February 27, 1995 Link to item Cite

Simultaneous pancreas-kidney transplantation at the University of Wisconsin.

Journal Article Clin Transpl · 1995 After a decade of rapid development, SPK transplantation has become routine at our center. There are several developments responsible for the current high level of success: UW preservation solution, improved surgical technique, advances in immunosuppressio ... Link to item Cite

Portal hypertension: surgical management in the 1990s.

Journal Article Surgery · October 1994 BACKGROUND: Although liver transplantation offers definitive treatment for portal hypertension with end-stage liver failure, surgical portosystemic shunts avoid the risks of transplantation and immunosuppressive therapy, and transjugular intrahepatic porto ... Link to item Cite

Comparison of Minnesota antilymphoblast globulin and Upjohn antithymocyte globulin for induction immunosuppression of human renal allografts.

Conference Surgery · October 1994 BACKGROUND: An analysis of heterologous polyclonal antisera in first renal transplants was continued after replacement of Minnesota antilymphoblast globulin (MALG) with antithymocyte globulin (ATGAM), testing the hypothesis that these are functionally equi ... Link to item Cite

100 consecutive liver transplants in infants and children: an 8-year experience.

Journal Article J Pediatr Surg · August 1994 Orthotopic liver transplantation has become the treatment of choice for most children and infants with end-stage liver disease. The purpose of this retrospective study was to examine the results of 100 consecutive liver transplants performed in infants and ... Full text Link to item Cite

Monitoring of kidney and simultaneous pancreas-kidney transplantation rejection by release of donor-specific, soluble HLA class I.

Journal Article Hum Immunol · July 1994 Using an HLA-A2-specific ELISA we monitored daily pretransplantation and posttransplantation sera from five kidney and eight simultaneous pancreas-kidney HLA-A2-negative recipients of HLA-A2-positive transplants during hospitalization. We found that, unlik ... Full text Link to item Cite

Use of donor serum to prevent passive transfer of hyperacute rejection.

Journal Article J Surg Res · July 1994 Organ transplantation in presensitized recipients continues to be contraindicated for heart and kidney recipients due to the risk of hyperacute rejection, which has no known treatment at this time. We tested whether donor serum, which contains soluble MHC ... Full text Link to item Cite

Induction of specific tolerance by intrathymic injection of recipient muscle cells transfected with donor class I major histocompatibility complex.

Journal Article Transplantation · April 15, 1994 Induction of tolerance to allogeneic MHC antigens has been a goal in the field of transplantation because it would reduce or eliminate the need for generalized immunosuppression. Although encouraging results have been obtained in experimental models by exp ... Link to item Cite

Clinical pancreas preservation and transplantation.

Journal Article Transplant Proc · April 1994 Link to item Cite

Urological complications and enteric conversion after pancreas transplantation with bladder drainage.

Journal Article Transplant Proc · April 1994 In summary, we feel that excellent 5-year patient and graft survival results can be obtained using SPK transplantation with bladder drainage technique. Despite the good results, a significant morbidity with prolonged hospitalization is seen after pancreas ... Link to item Cite

Changing spectrum of pediatric renal transplantation.

Journal Article Transplant Proc · February 1994 Link to item Cite

Immunity to MHC class I antigen after direct DNA transfer into skeletal muscle.

Journal Article J Immunol · January 15, 1994 Plasmid cDNA encoding the alpha-chain of either membrane-bound (pcRT.45) or secreted (pcRQ.B3) RT1Aa MHC class I Ag were transferred to Lewis (RT1(1)) rat skeletal muscle by direct injection. Rats were challenged 7 days later with an ACI (RT1a) heterotropi ... Link to item Cite

Clinical experience with human anodal trypsinogen (HAT) for detection of pancreatic allograft rejection.

Journal Article Transpl Int · 1994 To date one of the major dilemmas in clinical pancreas transplantation is the lack of a reliable indicator for pancreas rejection. In a consecutive series of 52 patients undergoing simultaneous pancreas and kidney (SPK) transplantation with bladder drainag ... Full text Link to item Cite

Living-unrelated renal donor transplantation: the UNOS experience, 1987-1991. United Network for Organ Sharing.

Journal Article Clin Transpl · 1994 1. LURD transplants were associated with excellent one-year graft survival of 92%. This survival was superior to that for cadaver transplants performed during the same period. 2. High-risk groups for LURDs are children (age < 18 years) and repeat transplan ... Link to item Cite

Two hundred consecutive simultaneous pancreas-kidney transplants with bladder drainage.

Journal Article Surgery · October 1993 BACKGROUND: Since 1982, 288 pancreas transplantations have been performed at the University of Wisconsin. This report reviews our experience with 200 consecutive simultaneous pancreas-kidney (SPK) transplantations during a 7-year period. METHODS: Two hundr ... Link to item Cite

Urological complications in 210 consecutive simultaneous pancreas-kidney transplants with bladder drainage.

Journal Article Ann Surg · October 1993 OBJECTIVE: The urological complications of 210 patients who underwent simultaneous pancreas-kidney (SPK) transplantation over a 7-year period were reviewed. SUMMARY BACKGROUND DATA: Worldwide, bladder drainage has become the accepted method of exocrine dra ... Full text Link to item Cite

Long-term results of liver transplantation for biliary atresia.

Journal Article Surgery · October 1993 BACKGROUND: Biliary atresia can be treated by portoenterostomy, which is primarily palliative, or by liver transplantation, which is primarily curative. The purpose of this study was to determine the long-term outcome of liver transplantation for the treat ... Link to item Cite

Histocompatibility and liver transplantation.

Journal Article Surgery · October 1993 BACKGROUND: The role of histocompatibility between donor and recipient in liver transplant rejection is unclear because of a paucity of data. The influence of human leukocyte antigen (HLA) type on immunologic graft loss was examined for primary liver trans ... Link to item Cite

Surgical refinements in liver transplantation

Journal Article Transplantation Proceedings · August 21, 1993 Cite

State of the art of liver transplantation in the USA

Journal Article Transplantation Proceedings · August 21, 1993 Cite

Renal transplantation in the cyclosporine era

Journal Article Transplantation Proceedings · August 21, 1993 Cite

Surgical refinements in liver transplantation.

Journal Article Transplant Proc · August 1993 Link to item Cite

State of the art of liver transplantation in the USA.

Journal Article Transplant Proc · August 1993 Link to item Cite

Renal transplantation in the cyclosporine era.

Journal Article Transplant Proc · August 1993 Link to item Cite

Retransplantation of the liver--a seven-year experience.

Journal Article Transplantation · May 1993 Three hundred and four patients underwent 362 liver transplants between July 1984 and April 1992. Fifty-eight retransplants were performed in 44 patients (14.5%). Thirty-four patients underwent two (77.3%), seven patients three (15.9%), two patients four ( ... Full text Link to item Cite

Risk factors for primary dysfunction after liver transplantation--a multivariate analysis.

Journal Article Transplantation · April 1993 In a retrospective analysis on 323 orthotopic liver transplant procedures performed between July 1984 and October 1991 the incidence of two forms of primary dysfunction (PDF) of the liver: primary nonfunction (PNF), and initial poor function (IPF) were stu ... Full text Link to item Cite

Update on preservation of liver grafts.

Journal Article Transplant Proc · April 1993 Link to item Cite

Living unrelated kidney donation: an underutilized resource?

Journal Article Transplant Proc · February 1993 Link to item Cite

Should abdominal cluster transplantation be abandoned?

Journal Article Transplant Proc · February 1993 Link to item Cite

A controlled, double-blind, randomized trial of verapamil and cyclosporine in cadaver renal transplant patients.

Journal Article Am J Kidney Dis · February 1993 Calcium channel blockers have immunomodulating effects in vitro and may be effective in preventing cyclosporine nephrotoxicity. We studied the effect of verapamil following renal transplantation on the incidence of rejection and cyclosporine nephrotoxicity ... Full text Link to item Cite

Renal transplantation at the University of Wisconsin in the cyclosporine era.

Journal Article Clin Transpl · 1993 1. Immunological graft loss in the cyclosporine (CsA) era has been decreasing over the past decade with current 94% immunological graft survival at one year. 2. The rates of both immunological graft loss and graft loss from all causes gradually decrease af ... Link to item Cite

Living unrelated kidney donation: An underutilized resource?

Journal Article Transplantation Proceedings · January 1, 1993 Cite

Simultaneous kidney-pancreas transplantation at the University of Wisconsin

Journal Article Transplantation Proceedings · January 1, 1993 Cite

Should abdominal cluster transplantation be abandoned?

Journal Article Transplantation Proceedings · January 1, 1993 Cite

Liver transplantation for alcoholic liver disease.

Journal Article Surgery · October 1992 BACKGROUND: Alcoholism is the leading cause of end-stage liver failure in the United States, but the application of liver transplantation to the treatment of alcoholic liver disease remains controversial because of medical and ethical concerns. Information ... Link to item Cite

Indications for enteric conversion after pancreas transplantation with bladder drainage.

Journal Article Surgery · October 1992 BACKGROUND: Bladder drainage has become the procedure of choice for 94% of transplant centers in North America. Bladder drainage is superior to other techniques as far as graft survival and technical success are concerned; however, the procedure is associa ... Link to item Cite

The use of UW solution in clinical transplantation. A 4-year experience.

Journal Article Ann Surg · June 1992 The development of the University of Wisconsin (UW) cold storage solution has extended safe preservation of the liver and pancreas from 6 to 24 hours or more. From May 1987 until November 1991, 288 livers and 163 simultaneous pancreas/kidney transplants we ... Full text Link to item Cite

Hyperlipidemia and transplantation: etiologic factors and therapy.

Journal Article J Am Soc Nephrol · June 1992 Hyperlipidemia is a well-recognized complication of renal transplantation. In long-term survivors of renal transplantation, cardiovascular disease accounts for the majority of patient deaths. In the cyclosporine era, cardiovascular disease has surpassed in ... Full text Link to item Cite

Gene transfer and expression in rat cardiac transplants.

Journal Article Transplantation · March 1992 Link to item Cite

The effect of donor age, recipient age, and HLA match on immunologic graft survival in cadaver renal transplant recipients.

Journal Article Transplantation · January 1992 We retrospectively analyzed 526 primary cadaver recipients transplanted at a single center to identify pretransplant variables that predict long-term survival with multivariate analysis. All recipients received at least three random blood transfusions and ... Full text Link to item Cite

EVALUATION OF PRESERVATION OF THE VARIOUS ORGANS FOR TRANSPLANTATION

Conference TRANSPLANTATION AND CLINICAL IMMUNOLOGY, VOL 24 · January 1, 1992 Link to item Cite

Experience with 100 consecutive simultaneous kidney-pancreas transplants with bladder drainage.

Journal Article Ann Surg · December 1991 From December 1985 to December 1989, 100 consecutive simultaneous pancreas-kidney (SPK) transplants were performed at the University of Wisconsin Hospital and Clinics. Bladder drainage technique was used for all grafts. One- and three-year patient survival ... Full text Link to item Cite

Orthotopic liver transplantation in patients 60 years of age and older.

Journal Article Transplantation · February 1991 Cyclosporine appears to have abrogated age as a contraindication to kidney transplantation in the elderly, although it is unclear whether this is true for other types of solid organ transplantation. We performed a retrospective analysis of liver transplant ... Full text Link to item Cite

Multivariate analysis of donor-specific versus random transfusion protocols in haploidentical living-related transplants.

Journal Article Transplantation · February 1991 A total of 127 haploidentical living-related transplants have been performed at our institution since March 1986. A donor-specific transfusion plus azathioprine protocol was used until July 1988 (n = 74) and a random transfusion (RT) protocol without AZA u ... Full text Link to item Cite

The predictive value of donor liver biopsies for the development of primary nonfunction after orthotopic liver transplantation.

Journal Article Transplantation · January 1991 Methods of accurately assessing the suitability of donor livers prior to transplantation are required if the incidence of primary nonfunction (PNF) is to be reduced. This study evaluated the ability of donor liver biopsies to predict the development of pri ... Full text Link to item Cite

Orthotopic liver transplantation in patients over 60 years of age

Conference Transplantation Proceedings · January 1, 1991 Cite

Ruptured splenic artery aneurysm: An unusual late complication following pancreas transplantation

Journal Article Clinical Transplantation · January 1, 1991 The vascular complications following pancreas transplantation have been well described and largely involve either re-operation for hemorrhage or vascular thrombosis. We describe herein a ruptured aneurysm of the transplanted splenic artery 6 years followin ... Cite

OKT3 vs ALG induction therapy in combined pancreas-kidney transplantation

Conference Transplantation Proceedings · January 1, 1991 Cite

Anomalous biliary ducts associated with duodenal atresia.

Journal Article J Pediatr Surg · December 1990 Duodenal atresia is rarely associated with anomalous biliary ducts that permit communication between the proximal and distal duodenal segments. Two such cases are presented herein and the literature is reviewed. Although the typical radiographic pattern of ... Full text Link to item Cite

Effect of RS-61443 in preventing rejection in sensitized recipients

Journal Article Surgical Forum · December 1, 1990 Cite

Pneumatosis intestinalis. Surgical management and clinical outcome.

Journal Article Ann Surg · August 1990 Pneumatosis intestinalis (PI) occurs in a wide variety of patients, some of whom require urgent surgery, while others can be observed with resolution of symptoms and radiographic findings. During 1 year, 27 patients with PI were prospectively evaluated for ... Full text Link to item Cite

Irradiation for xenogeneic transplantation.

Journal Article Radiother Oncol · May 1990 Xenogeneic transplantation (XT) is the transplantation of organs or tissues from a member of one species to a member of another. Mammalian species frequently have circulating antibody which is directed against the foreign organ irrespective of known prior ... Full text Link to item Cite

Living-unrelated renal transplantation at the University of Wisconsin.

Journal Article Clin Transpl · 1990 1. Use of LUrDs under a DST protocol results in a 70% actuarial graft survival at 6 years which is not statistically different from haploidentical or primary cadaver recipients transplanted over the same time period. 2. Sensitization is common, despite the ... Link to item Cite

Renal transplantation in the American black.

Journal Article Transplant Proc · December 1989 Link to item Cite

Cadaveric renal transplantation in the cyclosporine and OKT3 eras: an update of the University of Wisconsin-Madison experience.

Journal Article Clin Transpl · 1989 1. Quadruple immunosuppression yields excellent early renal allograft survival in primary renal transplant recipients when compared with non-primary renal transplant recipients. Although significant, the difference between primary and nonprimary recipients ... Link to item Cite

New approaches to immunosuppression for xenotransplantation

Conference Xenograft 25: proceedings of the International Congress, Xenograft 25. ICS880 · January 1, 1989 Cite

The influence of dose and dose rate of total lymphoid irradiation in the rat cardiac allograft model.

Journal Article Radiother Oncol · August 1987 Immunosuppression generated by total lymphoid irradiation (TLI) may be of use in solid organ transplantation. We have investigated the use of TLI in the rat cardiac allograft model. Lewis rats received TLI from a cobalt-60 machine. The daily dose was 1.25 ... Full text Link to item Cite

Xenograft survival in two species combinations using total-lymphoid irradiation and cyclosporine.

Journal Article Transplantation · February 1987 Total lymphoid irradiation (TLI) has profound immunosuppressive actions and has been applied successfully to allotransplantation but not xenotransplantation. Cyclosporine (CsA) has not generally permitted successful xenotransplantation of organs but has no ... Full text Link to item Cite

Infiltrating cell phenotypes and patterns associated with hepatic allograft rejection or acceptance.

Journal Article Transplantation · February 1987 The association of inflammatory cell infiltration with orthotopic rat liver transplant rejection was studied by immunopathologic evaluation of allografts at different time points using high- and low-responder strain combinations. PVG(RT-1c) recipients of A ... Full text Link to item Cite

Peptic ulcer disease following renal transplantation.

Journal Article Transplant Proc · February 1987 Link to item Cite

Hepatic transplantation into sensitized recipients. Demonstration of hyperacute rejection.

Journal Article Transplantation · January 1987 Hepatic transplantation into humorally presensitized patients has occasionally been performed without reported accelerated rejection. To study survival of orthotopic hepatic transplants in sensitized recipients a series of studies in rats were performed. L ... Full text Link to item Cite

α1-Adrenergic effects and liver regeneration

Journal Article Hepatology · 1987 The effects of several treatments involving α-adrenergic mechanisms upon the early stages of rat liver regeneration were examined. Catecholamine concentrations in rat plasma were measured at various times after hepatectomy and were found to be elevated rel ... Cite

Prolonged heart xenograft survival using combined total lymphoid irradiation and cyclosporine.

Journal Article J Heart Transplant · 1986 Total lymphoid irradiation and cyclosporine have profound immunosuppressive properties and permit successful heart allotransplantation. Cyclosporine used alone has not permitted consistently successful transplantation between species in all cases. Total ly ... Link to item Cite

The effect of cyclosporine, total lymphoid irradiation, and cobra venom factor on hyperacute rejection.

Journal Article J Heart Transplant · 1985 Transplantation into sensitized recipients is contraindicated due to the potential for hyperacute rejection. In order to study the mechanism of hyperacute rejection and the role of immunosuppression in the face of presensitization, we evaluated the effect ... Link to item Cite

Identification of bacterial antigens in circulating immune complexes of infective endocarditis.

Journal Article J Clin Invest · August 1982 The presence of circulating immune complexes (IC) in patients with infective endocarditis has been well documented but the contributions of host and bacterial components to these IC have not been defined. To study this question, IC were isolated from serum ... Full text Link to item Cite