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Joe Brice Weinberg

Professor Emeritus of Medicine
Medicine, Hematology
Duke Box 3396, Durham, NC 27708
E1006 VA Med Ctr, 508 Fulton St, Durham, NC 27705

Selected Publications


Shedding light on the effects of blood on meniscus tissue: the role of mononuclear leukocytes in mediating meniscus catabolism.

Journal Article Osteoarthritis Cartilage · May 21, 2024 OBJECTIVE: Traumatic meniscal injuries can cause acute pain, hemarthrosis (bleeding into the joint), joint immobility, and post-traumatic osteoarthritis (PTOA). However, the exact mechanism(s) by which PTOA develops following meniscal injuries is unknown. ... Full text Link to item Cite

Tumor mutational load is prognostic for progression to therapy among high-count monoclonal B-cell lymphocytosis.

Journal Article Blood Adv · May 14, 2024 High-count monoclonal B-cell lymphocytosis (HCMBL) is a precursor condition to chronic lymphocytic leukemia (CLL). We have shown that among individuals with HCMBL, the CLL-International Prognostic Index (CLL-IPI) is prognostic for time-to-first therapy (TT ... Full text Link to item Cite

Association of alpha globin gene copy number with exhaled nitric oxide in a cross-sectional study of healthy Black adults.

Journal Article BMJ Open Respir Res · December 20, 2023 INTRODUCTION: The genetic determinants of fractional exhalation of nitric oxide (FeNO), a marker of lung inflammation, are understudied in Black individuals. Alpha globin (HBA) restricts nitric oxide signalling in arterial endothelial cells via interaction ... Full text Link to item Cite

Virology under the Microscope-a Call for Rational Discourse.

Journal Article J Virol · February 28, 2023 Viruses have brought humanity many challenges: respiratory infection, cancer, neurological impairment and immunosuppression to name a few. Virology research over the last 60+ years has responded to reduce this disease burden with vaccines and antivirals. D ... Full text Link to item Cite

Effects of high-intensity interval training on health-related quality of life in chronic lymphocytic leukemia: A pilot study.

Journal Article J Geriatr Oncol · January 2023 INTRODUCTION: Chronic lymphocytic leukemia (CLL) is the most common incurable leukemia/lymphoma in the United States. Individuals with CLL are at risk for disability, frailty, and cancer-specific complications that negatively affect health-related quality ... Full text Link to item Cite

Mouse Adenovirus Type 1 Persistence Exacerbates Inflammation Induced by Allogeneic Bone Marrow Transplantation.

Journal Article J Virol · March 23, 2022 Bone marrow transplantation (BMT) recipients are at risk for substantial morbidity and mortality from human adenovirus infections, often in the setting of reactivation of persistent virus. Human adenovirus persistence in mucosal lymphocytes has been descri ... Full text Link to item Cite

Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans.

Journal Article Leukemia · January 2022 Monoclonal B-cell lymphocytosis (MBL) is a precursor to CLL. Other than age, sex, and CLL family-history, little is known about factors associated with MBL risk. A polygenic-risk-score (PRS) of 41 CLL-susceptibility variants has been found to be associated ... Full text Link to item Cite

Associations of clinical and circulating metabolic biomarkers with low physical fitness and function in adults with chronic lymphocytic leukemia.

Journal Article Front Oncol · 2022 Many patients with chronic lymphocytic leukemia (CLL) experience physical dysfunction and low overall fitness. It remains unknown what factors drive CLL physical dysfunction. We assessed physical function and metabolic lipoprotein panels in 106 patients wi ... Full text Link to item Cite

Optimization of Meniscus Cell Transduction Using Lentivirus and Adeno-Associated Virus for Gene Editing and Tissue Engineering Applications.

Journal Article Cartilage · December 2021 OBJECTIVES: The utilization of viral vectors to deliver genes of interest directly to meniscus cells and promote long-term modulation of gene expression may prove useful to enhance meniscus repair and regeneration. The objective of this study was to optimi ... Full text Link to item Cite

A pilot study of high-intensity interval training in older adults with treatment naïve chronic lymphocytic leukemia.

Journal Article Sci Rep · November 30, 2021 Chronic lymphocytic leukemia (CLL) is the most common leukemia in the USA, affecting predominantly older adults. CLL is characterized by low physical fitness, reduced immunity, and increased risk of secondary malignancies and infections. One approach to im ... Full text Link to item Cite

Novel Prognostic Markers in Previously Treated Chronic Lymphocytic Leukemia

Conference Blood · November 5, 2021 AbstractBackground: We need new biomarkers that manage CLL patients receiving novel chemotherapeutic agent treatments. In our earlier pilot study, we reported an association of inferior outcomes in those wit ... Full text Cite

Cerebrospinal Fluid Pterins, Pterin-Dependent Neurotransmitters, and Mortality in Pediatric Cerebral Malaria.

Journal Article J Infect Dis · October 28, 2021 BACKGROUND: Cerebral malaria (CM) pathogenesis remains incompletely understood. Having shown low systemic levels of tetrahydrobiopterin (BH4), an enzymatic cofactor for neurotransmitter synthesis, we hypothesized that BH4 and BH4-dependent neurotransmitter ... Full text Link to item Cite

Erratum

Journal Article The FASEB Journal · October 2021 Full text Cite

Degradation of endothelial glycocalyx in Tanzanian children with falciparum malaria.

Journal Article FASEB J · September 2021 A layer of glycocalyx covers the vascular endothelium serving important protective and homeostatic functions. The objective of this study was to determine if breakdown of the endothelial glycocalyx (eGC) occurs during malaria infection in children. Measure ... Full text Link to item Cite

Common genetic polymorphisms contribute to the association between chronic lymphocytic leukaemia and non-melanoma skin cancer.

Journal Article Int J Epidemiol · August 30, 2021 BACKGROUND: Epidemiological studies have demonstrated a positive association between chronic lymphocytic leukaemia (CLL) and non-melanoma skin cancer (NMSC). We hypothesized that shared genetic risk factors between CLL and NMSC could contribute to the asso ... Full text Link to item Cite

Shedding light on the effects of blood on meniscus tissue: the role of mononuclear leukocytes in mediating meniscus catabolism.

Journal Article Osteoarthritis Cartilage · May 21, 2024 OBJECTIVE: Traumatic meniscal injuries can cause acute pain, hemarthrosis (bleeding into the joint), joint immobility, and post-traumatic osteoarthritis (PTOA). However, the exact mechanism(s) by which PTOA develops following meniscal injuries is unknown. ... Full text Link to item Cite

Tumor mutational load is prognostic for progression to therapy among high-count monoclonal B-cell lymphocytosis.

Journal Article Blood Adv · May 14, 2024 High-count monoclonal B-cell lymphocytosis (HCMBL) is a precursor condition to chronic lymphocytic leukemia (CLL). We have shown that among individuals with HCMBL, the CLL-International Prognostic Index (CLL-IPI) is prognostic for time-to-first therapy (TT ... Full text Link to item Cite

Association of alpha globin gene copy number with exhaled nitric oxide in a cross-sectional study of healthy Black adults.

Journal Article BMJ Open Respir Res · December 20, 2023 INTRODUCTION: The genetic determinants of fractional exhalation of nitric oxide (FeNO), a marker of lung inflammation, are understudied in Black individuals. Alpha globin (HBA) restricts nitric oxide signalling in arterial endothelial cells via interaction ... Full text Link to item Cite

Virology under the Microscope-a Call for Rational Discourse.

Journal Article J Virol · February 28, 2023 Viruses have brought humanity many challenges: respiratory infection, cancer, neurological impairment and immunosuppression to name a few. Virology research over the last 60+ years has responded to reduce this disease burden with vaccines and antivirals. D ... Full text Link to item Cite

Effects of high-intensity interval training on health-related quality of life in chronic lymphocytic leukemia: A pilot study.

Journal Article J Geriatr Oncol · January 2023 INTRODUCTION: Chronic lymphocytic leukemia (CLL) is the most common incurable leukemia/lymphoma in the United States. Individuals with CLL are at risk for disability, frailty, and cancer-specific complications that negatively affect health-related quality ... Full text Link to item Cite

Mouse Adenovirus Type 1 Persistence Exacerbates Inflammation Induced by Allogeneic Bone Marrow Transplantation.

Journal Article J Virol · March 23, 2022 Bone marrow transplantation (BMT) recipients are at risk for substantial morbidity and mortality from human adenovirus infections, often in the setting of reactivation of persistent virus. Human adenovirus persistence in mucosal lymphocytes has been descri ... Full text Link to item Cite

Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans.

Journal Article Leukemia · January 2022 Monoclonal B-cell lymphocytosis (MBL) is a precursor to CLL. Other than age, sex, and CLL family-history, little is known about factors associated with MBL risk. A polygenic-risk-score (PRS) of 41 CLL-susceptibility variants has been found to be associated ... Full text Link to item Cite

Associations of clinical and circulating metabolic biomarkers with low physical fitness and function in adults with chronic lymphocytic leukemia.

Journal Article Front Oncol · 2022 Many patients with chronic lymphocytic leukemia (CLL) experience physical dysfunction and low overall fitness. It remains unknown what factors drive CLL physical dysfunction. We assessed physical function and metabolic lipoprotein panels in 106 patients wi ... Full text Link to item Cite

Optimization of Meniscus Cell Transduction Using Lentivirus and Adeno-Associated Virus for Gene Editing and Tissue Engineering Applications.

Journal Article Cartilage · December 2021 OBJECTIVES: The utilization of viral vectors to deliver genes of interest directly to meniscus cells and promote long-term modulation of gene expression may prove useful to enhance meniscus repair and regeneration. The objective of this study was to optimi ... Full text Link to item Cite

A pilot study of high-intensity interval training in older adults with treatment naïve chronic lymphocytic leukemia.

Journal Article Sci Rep · November 30, 2021 Chronic lymphocytic leukemia (CLL) is the most common leukemia in the USA, affecting predominantly older adults. CLL is characterized by low physical fitness, reduced immunity, and increased risk of secondary malignancies and infections. One approach to im ... Full text Link to item Cite

Novel Prognostic Markers in Previously Treated Chronic Lymphocytic Leukemia

Conference Blood · November 5, 2021 AbstractBackground: We need new biomarkers that manage CLL patients receiving novel chemotherapeutic agent treatments. In our earlier pilot study, we reported an association of inferior outcomes in those wit ... Full text Cite

Cerebrospinal Fluid Pterins, Pterin-Dependent Neurotransmitters, and Mortality in Pediatric Cerebral Malaria.

Journal Article J Infect Dis · October 28, 2021 BACKGROUND: Cerebral malaria (CM) pathogenesis remains incompletely understood. Having shown low systemic levels of tetrahydrobiopterin (BH4), an enzymatic cofactor for neurotransmitter synthesis, we hypothesized that BH4 and BH4-dependent neurotransmitter ... Full text Link to item Cite

Erratum

Journal Article The FASEB Journal · October 2021 Full text Cite

Degradation of endothelial glycocalyx in Tanzanian children with falciparum malaria.

Journal Article FASEB J · September 2021 A layer of glycocalyx covers the vascular endothelium serving important protective and homeostatic functions. The objective of this study was to determine if breakdown of the endothelial glycocalyx (eGC) occurs during malaria infection in children. Measure ... Full text Link to item Cite

Common genetic polymorphisms contribute to the association between chronic lymphocytic leukaemia and non-melanoma skin cancer.

Journal Article Int J Epidemiol · August 30, 2021 BACKGROUND: Epidemiological studies have demonstrated a positive association between chronic lymphocytic leukaemia (CLL) and non-melanoma skin cancer (NMSC). We hypothesized that shared genetic risk factors between CLL and NMSC could contribute to the asso ... Full text Link to item Cite

Physiological Fitness and the Pathophysiology of Chronic Lymphocytic Leukemia (CLL).

Journal Article Cells · May 11, 2021 Chronic lymphocytic leukemia (CLL) is associated with physical dysfunction and low overall fitness that predicts poor survival following the commencement of treatment. However, it remains unknown whether higher fitness provides antioncogenic effects. We id ... Full text Link to item Cite

Endothelial glycocalyx degradation and disease severity in Plasmodium vivax and Plasmodium knowlesi malaria.

Journal Article Sci Rep · May 7, 2021 Degradation of the endothelial glycocalyx is associated with mortality in adult falciparum malaria. However, its role in the pathogenesis of non-falciparum malaria is unknown. In Malaysian patients with knowlesi (n = 200) and vivax (n = 61) malaria, and in ... Full text Link to item Cite

Natural history of monoclonal B-cell lymphocytosis among relatives in CLL families.

Journal Article Blood · April 15, 2021 Chronic lymphocytic lymphoma (CLL) has one of the highest familial risks among cancers. Monoclonal B-cell lymphocytosis (MBL), the precursor to CLL, has a higher prevalence (13%-18%) in families with 2 or more members with CLL compared with the general pop ... Full text Link to item Cite

Blood in the joint: effects of hemarthrosis on meniscus health and repair techniques.

Journal Article Osteoarthritis Cartilage · April 2021 Injury to the meniscus is common and frequently leads to the development of post-traumatic osteoarthritis (PTOA). Many times meniscus injuries occur coincident with anterior cruciate ligament (ACL) injuries and lead to a bloody joint effusion. Hemarthrosis ... Full text Link to item Cite

Emerging antiviral therapeutics for human adenovirus infection: Recent developments and novel strategies.

Journal Article Antiviral Res · April 2021 Human adenoviruses (HAdV) are ubiquitous human pathogens that cause a significant burden of respiratory, ocular, and gastrointestinal illnesses. Although HAdV infections are generally self-limiting, pediatric and immunocompromised individuals are at partic ... Full text Link to item Cite

Vascular Dysfunction in Malaria: Understanding the Role of the Endothelial Glycocalyx.

Journal Article Front Cell Dev Biol · 2021 Malaria caused by Plasmodium falciparum results in over 400,000 deaths annually, predominantly affecting African children. In addition, non-falciparum species including vivax and knowlesi cause significant morbidity and mortality. Vascular dysfunction is a ... Full text Link to item Cite

Inhibition of Human Adenovirus Replication by the Importin α/β1 Nuclear Import Inhibitor Ivermectin.

Journal Article J Virol · August 31, 2020 Human adenoviruses (HAdV) are ubiquitous within the human population and comprise a significant burden of respiratory illnesses worldwide. Pediatric and immunocompromised individuals are at particular risk for developing severe disease; however, no approve ... Full text Link to item Cite

Effects of tumor necrosis factor on viral replication and pulmonary inflammation during acute mouse adenovirus type 1 respiratory infection.

Journal Article Virology · August 2020 CD8 T cells contribute to effective clearance of mouse adenovirus type 1 (MAV-1) and to virus-induced pulmonary inflammation. We characterized effects of a CD8 T cell effector, TNF, on MAV-1 pathogenesis. TNF inhibited MAV-1 replication in vitro. TNF defic ... Full text Link to item Cite

Early Endothelial Activation Precedes Glycocalyx Degradation and Microvascular Dysfunction in Experimentally Induced Plasmodium falciparum and Plasmodium vivax Infection.

Journal Article Infect Immun · April 20, 2020 Endothelial activation and microvascular dysfunction are key pathogenic processes in severe malaria. We evaluated the early role of these processes in experimentally induced Plasmodium falciparum and P. vivax infection. Participants were enrolled in induce ... Full text Link to item Cite

Evaluation of culture conditions for in vitro meniscus repair model systems using bone marrow-derived mesenchymal stem cells.

Journal Article Connect Tissue Res · 2020 Purpose: Meniscal injury and loss of meniscus tissue lead to osteoarthritis development. Therefore, novel biologic strategies are needed to enhance meniscus tissue repair. The purpose of this study was to identify a favorable culture medium for both bone m ... Full text Link to item Cite

Alpha Globin Copy Number and Exhaled Nitric Oxide in Black Individuals

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

Meniscus-Derived Matrix Bioscaffolds: Effects of Concentration and Cross-Linking on Meniscus Cellular Responses and Tissue Repair.

Journal Article Int J Mol Sci · December 19, 2019 Meniscal injuries, particularly in the avascular zone, have a low propensity for healing and are associated with the development of osteoarthritis. Current meniscal repair techniques are limited to specific tear types and have significant risk for failure. ... Full text Open Access Link to item Cite

Glycocalyx breakdown is increased in African children with cerebral and uncomplicated falciparum malaria.

Journal Article FASEB J · December 2019 Cerebral malaria (CM) from Plasmodium falciparum infection is associated with endothelial dysfunction and parasite sequestration. The glycocalyx (GCX), a carbohydrate-rich layer lining the endothelium, is crucial in vascular homeostasis. To evaluate the ro ... Full text Link to item Cite

Glycocalyx Breakdown Is Associated With Severe Disease and Fatal Outcome in Plasmodium falciparum Malaria.

Journal Article Clin Infect Dis · October 30, 2019 BACKGROUND: Interactions between the endothelium and infected erythrocytes play a major role in the pathogenesis of falciparum malaria, with microvascular dysfunction and parasite sequestration associated with worsening outcomes. The glycocalyx is a carboh ... Full text Link to item Cite

Association of elevated serumfree light chains with chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis.

Journal Article Blood Cancer J · August 5, 2019 Chronic lymphocytic leukemia (CLL) and its precursor, monoclonal B-cell lymphocytosis (MBL), are heritable. Serumfree light-chain (sFLC) measures are a prognostic factor for CLL, but their role in susceptibility to CLL is not clear. We investigated differe ... Full text Open Access Link to item Cite

Age-Dependent Effects of Immunoproteasome Deficiency on Mouse Adenovirus Type 1 Pathogenesis.

Journal Article J Virol · August 1, 2019 Acute respiratory infection with mouse adenovirus type 1 (MAV-1) induces activity of the immunoproteasome, an inducible form of the proteasome that shapes CD8 T cell responses by enhancing peptide presentation by major histocompatibility complex (MHC) clas ... Full text Link to item Cite

Meniscus-Derived Matrix Scaffolds Promote the Integrative Repair of Meniscal Defects.

Journal Article Sci Rep · June 18, 2019 Meniscal tears have a poor healing capacity, and damage to the meniscus is associated with significant pain, disability, and progressive degenerative changes in the knee joint that lead to osteoarthritis. Therefore, strategies to promote meniscus repair an ... Full text Open Access Link to item Cite

Kinetic and Cross-Sectional Studies on the Genesis of Hypoargininemia in Severe Pediatric Plasmodium falciparum Malaria.

Journal Article Infect Immun · April 2019 The low bioavailability of nitric oxide (NO) and its precursor, arginine, contributes to the microvascular pathophysiology of severe falciparum malaria. To better characterize the mechanisms underlying hypoargininemia in severe malaria, we measured the pla ... Full text Link to item Cite

SET alpha and SET beta mRNA isoforms in chronic lymphocytic leukaemia.

Journal Article Br J Haematol · February 2019 Alteration in RNA splicing is implicated in carcinogenesis and progression. Mutations in spliceosome genes and alternative splicing of other genes have been noted in chronic lymphocytic leukaemia (CLL), a common B cell malignancy with heterogeneous outcome ... Full text Link to item Cite

Reflections on and future of hematologic malignancies research in the Veterans Health Administration.

Journal Article Semin Oncol · 2019 Research in the Veterans Health Administration (VHA) has played an integral part in learning about cancer biology and treatment. Here we provide examples of past research performed in the VHA focusing on hematologic malignancies, and identify future opport ... Full text Link to item Cite

THE IMPACT OF ALPHA-GLOBIN GENE VARIANTS ON ENDOTHELIAL FUNCTION IN ADULTS WITH SEVERE MALARIA

Conference AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE · January 1, 2019 Link to item Cite

Clinical outcomes in chronic lymphocytic leukaemia associated with expression of CD5, a negative regulator of B-cell receptor signalling.

Journal Article Br J Haematol · December 2018 Chronic lymphocytic leukaemia (CLL) is characterized by expression of CD5 on clonal B cells, and is partly driven by activated B-cell receptor (BCR) signalling. While CD5 is known to be a negative regulator of BCR signalling, it is unknown if variability i ... Full text Link to item Cite

Exercise and Chronic Lymphocytic Leukemia (CLL) - Relationships Among Physical Activity, Fitness, & Inflammation, and Their Impacts on CLL Patients

Conference Blood · November 29, 2018 AbstractIntroduction Exercise has potent immune enhancing and anti-inflammatory effects in healthy adults, and is increasingly recognized as a beneficial adjunct to cancer care. Inc ... Full text Cite

Fas activity mediates airway inflammation during mouse adenovirus type 1 respiratory infection.

Journal Article Virology · August 2018 CD8 T cells play a key role in clearance of mouse adenovirus type 1 (MAV-1) from the lung and contribute to virus-induced airway inflammation. We tested the hypothesis that interactions between Fas ligand (FasL) and Fas mediate the antiviral and proinflamm ... Full text Link to item Cite

Ablation of the leptin receptor in myeloid cells impairs pulmonary clearance of Streptococcus pneumoniae and alveolar macrophage bactericidal function.

Journal Article Am J Physiol Lung Cell Mol Physiol · July 1, 2018 Leptin is a pleiotropic hormone produced by white adipose tissue that regulates appetite and many physiological functions, including the immune response to infection. Genetic leptin deficiency in humans and mice impairs host defenses against respiratory tr ... Full text Link to item Cite

Association of polygenic risk score with the risk of chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis.

Journal Article Blood · June 7, 2018 Inherited loci have been found to be associated with risk of chronic lymphocytic leukemia (CLL). A combined polygenic risk score (PRS) of representative single nucleotide polymorphisms (SNPs) from these loci may improve risk prediction over individual SNPs ... Full text Link to item Cite

LOCAL APPLICATION OF D-LACTIC ACID DIMER IS SELECTIVELY CYTOTOXIC WHEN APPLIED TO CANCER CELLS

Internet Publication · March 29, 2018 The experimental data supports the cytotoxic mechanism of D-lactic acid dimer via the Warburg effect. ... Open Access Cite

Mouse adenovirus type 1 infection of adipose tissue.

Journal Article Virus Res · January 15, 2018 Human adenovirus (HAdV) type 36 seropositivity has been linked to obesity in humans. That link is supported by a small number of studies using HAdV-36 infection of animals that are not natural hosts for HAdVs. In this study, we infected mice with mouse ade ... Full text Link to item Cite

DO ALPHA GLOBIN GENE VARIANTS AFFECT ENDOTHELIAL FUNCTION IN PATIENTS WITH SEVERE MALARIA?

Conference AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE · January 1, 2018 Link to item Cite

Contributions of CD8 T cells to the pathogenesis of mouse adenovirus type 1 respiratory infection.

Journal Article Virology · July 2017 CD8 T cells are key components of the immune response to viruses, but their roles in the pathogenesis of adenovirus respiratory infection have not been characterized. We used mouse adenovirus type 1 (MAV-1) to define CD8 T cell contributions to the pathoge ... Full text Link to item Cite

Ruxolitinib in treatment of refractory hypereosinophilic syndrome.

Conference Journal of Clinical Oncology · March 1, 2017 73 Background: Hypereosinophilic syndrome (HES) is a rare hematologic disorder in which the eosinophils proliferate and infiltrate and damage multiple organs. Without treatment, the condition is fatal, usually due to cardiac dysf ... Full text Cite

Enhanced CDC of B cell chronic lymphocytic leukemia cells mediated by rituximab combined with a novel anti-complement factor H antibody.

Journal Article PLoS One · 2017 Rituximab therapy for B cell chronic lymphocytic leukemia (B-CLL) has met with mixed success. Among several factors to which resistance can be attributed is failure to activate complement dependent cytotoxicity (CDC) due to protective complement regulatory ... Full text Link to item Cite

Decreased Microvascular Function in Tanzanian Children With Severe and Uncomplicated Falciparum Malaria.

Journal Article Open Forum Infect Dis · 2017 Microvascular function and oxygen consumption affect oxygen homeostasis but have not been assessed in African children with malaria. Microvascular function in Tanzanian children with severe malaria (SM) or uncomplicated malaria were 39% and 72%, respective ... Full text Link to item Cite

Ruxolitinib Used to Treat Hypereosinophilic Syndrome

Conference Blood · December 2, 2016 AbstractIntroduction: Hypereosinophilic syndrome (HES) is a rare hematologic disorder in which the eosinophils proliferate and infiltrate and damage multiple organs. Without treatment, the condition is fatal ... Full text Cite

Fingolimod Is Cytotoxic in Acute Myeloid Leukemia Independent of Additional Chemotherapeutic Agents

Conference Blood · December 2, 2016 AbstractINTRODUCTION:Conventional treatment of acute myeloid leukemia (AML) remains largely unchanged for over thirty years. With poor overall survival and disease cure rates ... Full text Cite

Surface CD5 Protein Risk Stratifies Chronic Lymphocytic Leukemia

Conference Blood · December 2, 2016 AbstractIntroduction: Chronic Lymphocytic Leukemia (CLL) is a malignancy characterized by B-lymphocytes with aberrant expression of CD5. In normal T-lymphocytes, CD5 is an important regulator of T-cell recep ... Full text Cite

Nitric Oxide-Dependent Endothelial Dysfunction and Reduced Arginine Bioavailability in Plasmodium vivax Malaria but No Greater Increase in Intravascular Hemolysis in Severe Disease.

Journal Article J Infect Dis · November 15, 2016 BACKGROUND: Pathogenesis of severe Plasmodium vivax malaria is poorly understood. Endothelial dysfunction and reduced nitric oxide (NO) bioavailability characterize severe falciparum malaria, but have not been assessed in severe vivax malaria. METHODS: In ... Full text Link to item Cite

Interferon-dependent immunoproteasome activity during mouse adenovirus type 1 infection.

Journal Article Virology · November 2016 The immunoproteasome is an inducible host mechanism that aids in the clearance of damaged proteins. The immunoproteasome also influences immune function by enhancing peptide presentation by MHC class I and promotes inflammation via IκB degradation and acti ... Full text Link to item Cite

Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia.

Journal Article J Immunol · September 15, 2016 Leukemia can promote T cell dysfunction and exhaustion that contributes to increased susceptibility to infection and mortality. The treatment-independent mechanisms that mediate leukemia-associated T cell impairments are poorly understood, but metabolism t ... Full text Link to item Cite

Monocyte polarization in children with falciparum malaria: relationship to nitric oxide insufficiency and disease severity.

Journal Article Sci Rep · July 7, 2016 We earlier established that nitric oxide (NO) is protective against severe malaria and that arginine and NO levels are reduced in malaria patients. We now show that an M2-like blood monocyte phenotype is significantly associated with hypoargininemia, NO in ... Full text Link to item Cite

Relationship of blood monocytes with chronic lymphocytic leukemia aggressiveness and outcomes: a multi-institutional study.

Journal Article Am J Hematol · July 2016 Monocyte-derived cells, constituents of the cancer microenvironment, support chronic lymphocytic leukemia (CLL) cell survival in vitro via direct cell-cell interaction and secreted factors. We hypothesized that circulating absolute monocyte count (AMC) ref ... Full text Link to item Cite

Alveolar Epithelial Cell-Derived Prostaglandin E2 Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation.

Journal Article J Immunol · June 15, 2016 Preservation of gas exchange mandates that the pulmonary alveolar surface restrain unnecessarily harmful inflammatory responses to the many challenges to which it is exposed. These responses reflect the cross-talk between alveolar epithelial cells (AECs) a ... Full text Link to item Cite

Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice.

Journal Article Am J Physiol Lung Cell Mol Physiol · June 1, 2016 The production of prostaglandin E2 (PGE2) increases dramatically during pneumococcal pneumonia, and this lipid mediator impairs alveolar macrophage (AM)-mediated innate immune responses. Microsomal prostaglandin E synthase-1 (mPGES-1) is a key enzyme invol ... Full text Link to item Cite

Interleukin-17A Contributes to the Control of Streptococcus pyogenes Colonization and Inflammation of the Female Genital Tract.

Journal Article Sci Rep · May 31, 2016 Postpartum women are at increased risk of developing puerperal sepsis caused by group A Streptococcus (GAS). Specific GAS serotypes, including M1 and M28, are more commonly associated with puerperal sepsis. However, the mechanisms of GAS genital tract infe ... Full text Link to item Cite

An investigation of vago-regulatory and health-behavior accounts for increased inflammation in posttraumatic stress disorder.

Journal Article J Psychosom Res · April 2016 OBJECTIVE: Posttraumatic stress disorder (PTSD) has been linked to chronic inflammation, a condition that poses a risk for cardiovascular disease. Attenuated vagal activity has been proposed as a potential mediator of PTSD and inflammation, although associ ... Full text Link to item Cite

Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.

Journal Article Nat Commun · March 9, 2016 Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide associatio ... Full text Link to item Cite

Prostaglandin E2 production during neonatal respiratory infection with mouse adenovirus type 1.

Journal Article Virus Res · March 2, 2016 Neonatal mice are more susceptible than adults to mouse adenovirus type 1 (MAV1) respiratory infection. In adult mice, MAV-1 respiratory infection induces production of prostaglandin E2 (PGE2), a lipid mediator that exerts suppressive effects on a variety ... Full text Link to item Cite

INCREASED TOTAL BODY ARGININE FLUX AND DECREASED NITRIC OXIDE SYNTHESIS IN SEVERE FALCIPARUM MALARIA

Conference AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE · October 1, 2015 Link to item Cite

Abstract A24: The dual PI3K δ/γ inhibitor, RP6530, in combination with ibrutinib or fludarabine, synergistically enhances cytotoxicity in primary CLL cells in vitro.

Conference Clinical Cancer Research · September 1, 2015 AbstractBackground: The PI3K pathway is a central pro-survival mechanism in chronic lymphocytic leukemia (CLL). While the delta isoform of PI3K is largely associated with B-cell signaling, gamma is involved ... Full text Cite

Impaired systemic tetrahydrobiopterin bioavailability and increased dihydrobiopterin in adult falciparum malaria: association with disease severity, impaired microvascular function and increased endothelial activation.

Journal Article PLoS Pathog · March 2015 Tetrahydrobiopterin (BH₄) is a co-factor required for catalytic activity of nitric oxide synthase (NOS) and amino acid-monooxygenases, including phenylalanine hydroxylase. BH4 is unstable: during oxidative stress it is non-enzymatically oxidized to dihydro ... Full text Link to item Cite

Impaired systemic tetrahydrobiopterin bioavailability and increased oxidized biopterins in pediatric falciparum malaria: association with disease severity.

Journal Article PLoS Pathog · March 2015 Decreased bioavailability of nitric oxide (NO) is a major contributor to the pathophysiology of severe falciparum malaria. Tetrahydrobiopterin (BH4) is an enzyme cofactor required for NO synthesis from L-arginine. We hypothesized that systemic levels of BH ... Full text Link to item Cite

Prostaglandin E2 Production and T Cell Function in Mouse Adenovirus Type 1 Infection following Allogeneic Bone Marrow Transplantation.

Journal Article PLoS One · 2015 Adenovirus infections are important complications of bone marrow transplantation (BMT). We demonstrate delayed clearance of mouse adenovirus type 1 (MAV-1) from lungs of mice following allogeneic BMT. Virus-induced prostaglandin E2 (PGE2) production was gr ... Full text Link to item Cite

The immunoproteasome and viral infection: a complex regulator of inflammation.

Journal Article Front Microbiol · 2015 During viral infection, proper regulation of immune responses is necessary to ensure successful viral clearance with minimal host tissue damage. Proteasomes play a crucial role in the generation of antigenic peptides for presentation on MHC class I molecul ... Full text Link to item Cite

Proinflammatory effects of interferon gamma in mouse adenovirus 1 myocarditis.

Journal Article J Virol · January 2015 UNLABELLED: Adenoviruses are frequent causes of pediatric myocarditis. Little is known about the pathogenesis of adenovirus myocarditis, and the species specificity of human adenoviruses has limited the development of animal models, which is a significant ... Full text Link to item Cite

Decreased endothelial nitric oxide bioavailability, impaired microvascular function, and increased tissue oxygen consumption in children with falciparum malaria.

Journal Article J Infect Dis · November 15, 2014 Endothelial nitric oxide (NO) bioavailability, microvascular function, and host oxygen consumption have not been assessed in pediatric malaria. We measured NO-dependent endothelial function by using peripheral artery tonometry to determine the reactive hyp ... Full text Link to item Cite

Abstract 4518: The PI3K-δ inhibitor TGR-1202 induces cytotoxicity and inhibits phosphorylation of AKT in 17p deleted and non-17p deleted CLL cells in vitro

Conference Cancer Research · October 1, 2014 AbstractBackground: The PI3K pathway is a central pro-survival mechanism in chronic lymphocytic leukemia (CLL), with expression of the delta isoform of PI3K largely restricted to lymphocytes. Clinical evalua ... Full text Cite

Dimethylarginines: endogenous inhibitors of nitric oxide synthesis in children with falciparum malaria.

Journal Article J Infect Dis · September 15, 2014 Featured Publication BACKGROUND: Nitric oxide (NO) bioavailability is impaired in children and adults with severe falciparum malaria (SM). Asymmetric-dimethylarginine (ADMA) limits NO production by inhibiting NO synthase and is increased in adult SM. The role of ADMA in the pa ... Full text Link to item Cite

Quantification of Plasmodium falciparum histidine-rich protein-2 in cerebrospinal spinal fluid from cerebral malaria patients.

Journal Article Am J Trop Med Hyg · September 2014 A cerebrospinal fluid (CSF) biomarker for cerebral malaria (CM) has not been validated. We examined the detection, semiquantification, and clinical use of the Plasmodium falciparum histidine-rich protein-2 (PfHRP-2) as a parasite antigen biomarker for CM. ... Full text Link to item Cite

Neutrophils with myeloid derived suppressor function deplete arginine and constrain T cell function in septic shock patients.

Journal Article Crit Care · August 1, 2014 INTRODUCTION: Impaired T cell function in sepsis is associated with poor outcome, but the mechanisms are unclear. In cancer, arginase-expressing myeloid derived suppressor cells (MDSCs) deplete arginine, impair T cell receptor CD3 zeta-chain expression and ... Full text Link to item Cite

IL-17 contributes to neutrophil recruitment but not to control of viral replication during acute mouse adenovirus type 1 respiratory infection.

Journal Article Virology · May 2014 IL-17-producing CD4(+) helper T cells (Th17 cells) promote inflammatory responses to many pathogens. We used mouse adenovirus type 1 (MAV-1) to determine contributions of IL-17 to adenovirus pathogenesis. MAV-1 infection of C57BL/6 mice upregulated lung ex ... Full text Link to item Cite

Perifosine treatment in chronic lymphocytic leukemia: results of a phase II clinical trial and in vitro studies.

Journal Article Leuk Lymphoma · May 2014 Abstract Because of the importance of the phosphoinositide 3-kinase (PI3K)/AKT pathway in chronic lymphocytic leukemia (CLL), we evaluated in vitro cytotoxicity induced by perifosine, an AKT inhibitor, in CLL lymphocytes and found that the mean 50% effecti ... Full text Link to item Cite

Increased plasma arginase activity in human sepsis: association with increased circulating neutrophils.

Journal Article Clin Chem Lab Med · April 2014 Featured Publication BACKGROUND: The pathophysiology of sepsis is incompletely understood. Impaired bioavailability of L-arginine, the substrate for NO synthesis, is linked to sepsis severity, and plasma arginase has been linked to hypoargininemia in other disease states. Circ ... Full text Link to item Cite

Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE₂.

Journal Article Cell Host Microbe · January 15, 2014 Although imbalances in gut microbiota composition, or "dysbiosis," are associated with many diseases, the effects of gut dysbiosis on host systemic physiology are less well characterized. We report that gut dysbiosis induced by antibiotic (Abx) treatment p ... Full text Link to item Cite

Molecular and Clinical Associations Between Vitamin D and Chronic Lymphocytic Leukemia

Conference Blood · November 15, 2013 AbstractIntroductionVitamin D deficiency is common in the general population. Approximately 25-50% of adult patients seen at routine v ... Full text Cite

Intrauterine group A streptococcal infections are exacerbated by prostaglandin E2.

Journal Article J Immunol · September 1, 2013 Streptococcus pyogenes (Group A Streptococcus; GAS) is a major cause of severe postpartum sepsis, a re-emerging cause of maternal morbidity and mortality worldwide. Immunological alterations occur during pregnancy to promote maternofetal tolerance, which m ... Full text Link to item Cite

Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.

Journal Article Nat Genet · August 2013 Featured Publication Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for C ... Full text Link to item Cite

Mapping of the IRF8 gene identifies a 3'UTR variant associated with risk of chronic lymphocytic leukemia but not other common non-Hodgkin lymphoma subtypes.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2013 Featured Publication BACKGROUND: Our genome-wide association study (GWAS) of chronic lymphocytic leukemia (CLL) identified 4 highly correlated intronic variants within the IRF8 gene that were associated with CLL. These results were further supported by a recent meta-analysis o ... Full text Link to item Cite

Corrigendum

Journal Article British Journal of Haematology · March 2013 Full text Cite

Prostaglandin E2 induction during mouse adenovirus type 1 respiratory infection regulates inflammatory mediator generation but does not affect viral pathogenesis.

Journal Article PLoS One · 2013 Respiratory viruses cause substantial disease and are a significant healthcare burden. Virus-induced inflammation can be detrimental to the host, causing symptoms during acute infection and leading to damage that contributes to long-term residual lung dise ... Full text Link to item Cite

Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function.

Journal Article Leukemia · January 2013 Featured Publication Chronic lymphocytic leukemia (CLL) can be immunosuppressive in humans and mice, and CLL cells share multiple phenotypic markers with regulatory B cells that are competent to produce interleukin (IL)-10 (B10 cells). To identify functional links between CLL ... Full text Link to item Cite

Clinical and biological relevance of genomic heterogeneity in chronic lymphocytic leukemia.

Journal Article PLoS One · 2013 BACKGROUND: Chronic lymphocytic leukemia (CLL) is typically regarded as an indolent B-cell malignancy. However, there is wide variability with regards to need for therapy, time to progressive disease, and treatment response. This clinical variability is du ... Full text Link to item Cite

The inhibition by interleukin 1 of MSC chondrogenesis and the development of biomechanical properties in biomimetic 3D woven PCL scaffolds.

Journal Article Biomaterials · December 2012 Featured Publication Tissue-engineered constructs designed to treat large cartilage defects or osteoarthritic lesions may be exposed to significant mechanical loading as well as an inflammatory environment upon implantation in an injured or diseased joint. We hypothesized that ... Full text Link to item Cite

Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes.

Journal Article Br J Haematol · December 2012 A recent meta-analysis of three genome-wide association studies of chronic lymphocytic leukaemia (CLL) identified two common variants at the 6p21.31 locus that are associated with CLL risk. To verify and further explore the association of these variants wi ... Full text Link to item Cite

CD38 Variation in Chronic Lymphocytic Leukemia

Conference Blood · November 16, 2012 AbstractAbstract 4576Background:Chronic lymphocytic leukemia (CLL) has a highly variable clinical cou ... Full text Cite

The Metabolic Signature of CLL: Enhanced Glucose Metabolism in A Subset of High-Risk CLL Patients

Conference Blood · November 16, 2012 AbstractAbstract 1785Background:Chronic lymphocytic leukemia (CLL), the most common hematopoietic mal ... Full text Cite

Chronic lymphocytic leukemia in African Americans.

Journal Article Leuk Lymphoma · November 2012 Chronic lymphocytic leukemia (CLL) is the most prevalent leukemia in the United States with almost 4390 attributable deaths per year. Epidemiologic data compiled by the Surveillance, Epidemiology and End Results (SEER) program identifies important differen ... Full text Link to item Cite

Single nucleotide polymorphisms and inherited risk of chronic lymphocytic leukemia among African Americans.

Journal Article Blood · August 23, 2012 Featured Publication The incidence of chronic lymphocytic leukemia (CLL) is significantly lower in African Americans than whites, but overall survival is inferior. The biologic basis for these observations remains unexplored. We hypothesized that germline genetic predispositio ... Full text Link to item Cite

Rhizobium radiobacter bacteremia in a neonate.

Journal Article Infection · August 2012 Rhizobium radiobacter bacteremia is an infrequent cause of human infection. We report a rare manifestation of R. radiobacter infection in which bacteremia occurred in a newborn infant without other risk factors. ... Full text Link to item Cite

Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia.

Journal Article Blood · July 26, 2012 We performed a meta-analysis of 3 genome-wide association studies to identify additional common variants influencing chronic lymphocytic leukemia (CLL) risk. The discovery phase was composed of genome-wide association study data from 1121 cases and 3745 co ... Full text Link to item Cite

Susceptibility to acute mouse adenovirus type 1 respiratory infection and establishment of protective immunity in neonatal mice.

Journal Article J Virol · April 2012 There is an incomplete understanding of the differences between neonatal immune responses that contribute to the increased susceptibility of neonates to some viral infections. We tested the hypothesis that neonates are more susceptible than adults to mouse ... Full text Link to item Cite

Neonatal rhinovirus infection induces mucous metaplasia and airways hyperresponsiveness.

Journal Article J Immunol · March 15, 2012 Recent studies link early rhinovirus (RV) infections to later asthma development. We hypothesized that neonatal RV infection leads to an IL-13-driven asthma-like phenotype in mice. BALB/c mice were inoculated with RV1B or sham on day 7 of life. Viral RNA p ... Full text Link to item Cite

Phase II study of cenersen, an antisense inhibitor of p53, in combination with fludarabine, cyclophosphamide and rituximab for high-risk chronic lymphocytic leukemia.

Journal Article Leuk Lymphoma · February 2012 Patients with chronic lymphocytic leukemia (CLL) with deletion or mutation of TP53 have exceedingly poor clinical outcomes. Cenersen, an oligonucleotide targeting TP53, has been shown to abrogate the activity of TP53 gain-of-function mutants and to increas ... Full text Link to item Cite

Eicosanoids and respiratory viral infection: coordinators of inflammation and potential therapeutic targets.

Journal Article Mediators Inflamm · 2012 Viruses are frequent causes of respiratory infection, and viral respiratory infections are significant causes of hospitalization, morbidity, and sometimes mortality in a variety of patient populations. Lung inflammation induced by infection with common res ... Full text Link to item Cite

Plasma Plasmodium falciparum histidine-rich protein-2 concentrations are associated with malaria severity and mortality in Tanzanian children.

Journal Article PLoS One · 2012 Plasma Plasmodium falciparum histidine-rich protein-2 (PfHRP-2) concentrations, a measure of parasite biomass, have been correlated with malaria severity in adults, but not yet in children. We measured plasma PfHRP-2 in Tanzanian children with uncomplicate ... Full text Link to item Cite

SET oncoprotein overexpression in B-cell chronic lymphocytic leukemia and non-Hodgkin lymphoma: a predictor of aggressive disease and a new treatment target.

Journal Article Blood · October 13, 2011 Featured Publication B-cell chronic lymphocytic leukemia (CLL), an incurable leukemia, is characterized by defective apoptosis. We found that the SET oncoprotein, a potent inhibitor of the protein phosphatase 2A (PP2A) tumor suppressor, is overexpressed in primary CLL cells an ... Full text Link to item Cite

Limited effects of Muc1 deficiency on mouse adenovirus type 1 respiratory infection.

Journal Article Virus Res · September 2011 Muc1 (MUC1 in humans) is a membrane-tethered mucin that exerts anti-inflammatory effects in the lung during bacterial infection. Muc1 and other mucins are also likely to form a protective barrier in the lung. We used mouse adenovirus type 1 (MAV-1, also kn ... Full text Link to item Cite

Immunophenotypic and gene expression analysis of monoclonal B-cell lymphocytosis shows biologic characteristics associated with good prognosis CLL.

Journal Article Leukemia · September 2011 Featured Publication Monoclonal B-cell lymphocytosis (MBL) is a hematologic condition wherein small B-cell clones can be detected in the blood of asymptomatic individuals. Most MBL have an immunophenotype similar to chronic lymphocytic leukemia (CLL), and 'CLL-like' MBL is a p ... Full text Link to item Cite

Immunoglobulin class switch recombination in chronic lymphocytic leukemia.

Journal Article Leuk Lymphoma · July 2011 During B lymphocyte maturation, a subset of B cells undergo class switch recombination (CSR), a process wherein the heavy chain constant region is changed to a different immunoglobulin isotype without introduction of variable region mutations. CSR thus all ... Full text Link to item Cite

Sleep and fatigue in mice infected with murine gammaherpesvirus 68.

Journal Article Brain Behav Immun · May 2011 Fatigue, a common symptom of many acute and chronic medical conditions, reduces both quality of life and workplace productivity and can be disabling. However, the pathophysiologic mechanisms that underlie fatigue can be difficult to study in human populati ... Full text Link to item Cite

Host genetic variation in susceptibility to Punta Toro virus.

Journal Article Virus Res · April 2011 Infection of small laboratory animals by Punta Toro virus (PTV), family Bunyaviridae, genus Phlebovirus, is a model for the study of the human pathogen Rift Valley fever virus (RVFV). We have identified inbred mouse strains with significant differences in ... Full text Link to item Cite

Immunologic aspects of monoclonal B-cell lymphocytosis.

Journal Article Immunol Res · April 2011 Monoclonal B-cell lymphocytosis (MBL) is a preclinical hematologic condition wherein small numbers of clonal B cells can be detected in the blood of otherwise healthy individuals. Most MBL have a surface immunophenotype nearly identical to that of chronic ... Full text Link to item Cite

Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL.

Journal Article Blood · February 10, 2011 Prior genome-wide association (GWA) studies have identified 10 susceptibility loci for risk of chronic lymphocytic leukemia (CLL). To identify additional loci, we performed a GWA study in 407 CLL cases (of which 102 had a family history of CLL) and 296 con ... Full text Link to item Cite

Interleukin-1, tumor necrosis factor-alpha, and transforming growth factor-beta 1 and integrative meniscal repair: influences on meniscal cell proliferation and migration.

Journal Article Arthritis Res Ther · 2011 Featured Publication INTRODUCTION: Interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) are up-regulated in injured and osteoarthritic knee joints. IL-1 and TNF-α inhibit integrative meniscal repair; however, the mechanisms by which this inhibition occurs are not fully und ... Full text Link to item Cite

Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs.

Journal Article Blood · December 2, 2010 A role for microRNA (miRNA) has been recognized in nearly every biologic system examined thus far. A complete delineation of their role must be preceded by the identification of all miRNAs present in any system. We elucidated the complete small RNA transcr ... Full text Link to item Cite

A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults.

Journal Article Malar J · October 29, 2010 BACKGROUND: Severe malaria (SM) syndromes caused by Plasmodium falciparum infection result in major morbidity and mortality each year. However, only a fraction of P. falciparum infections develop into SM, implicating host genetic factors as important deter ... Full text Link to item Cite

Common occurrence of monoclonal B-cell lymphocytosis among members of high-risk CLL families.

Journal Article Br J Haematol · October 2010 Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic haematological condition characterized by low absolute levels of B-cell clones with a surface immunophenotype similar to that of chronic lymphocytic leukaemia (CLL). In the general population, MBL in ... Full text Link to item Cite

LMP-420: a novel purine nucleoside analog with potent cytotoxic effects for CLL cells and minimal toxicity for normal hematopoietic cells.

Journal Article Leukemia · September 2010 Featured Publication B-cell chronic lymphocytic leukemia (CLL) is characterized by slow accumulation of malignant cells, which are supported in the microenvironment by cell-cell interactions and soluble cytokines such as tumor necrosis factor (TNF). We evaluated the effect of ... Full text Link to item Cite

Human metapneumovirus and respiratory syncytial virus: subtle differences but comparable severity.

Journal Article Infect Dis Rep · August 4, 2010 Human metapneumovirus (hMPV) is a recently discovered virus that causes respiratory illness in children that can lead to hospitalization. Our study was undertaken to further understand hMPV-associated illness, compare clinical characteristics of hMPV and r ... Full text Link to item Cite

Monoclonal B cell lymphocytosis.

Journal Article Leuk Lymphoma · August 2010 Monoclonal B lymphocytosis (MBL) is an asymptomatic clinical syndrome wherein small B cell clones are detectable in the peripheral blood. MBL is common in the adult population, with an estimated prevalence of greater than 3% among individuals over age 50. ... Full text Link to item Cite

Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32.

Journal Article Nat Genet · August 2010 Featured Publication To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, c ... Full text Link to item Cite

Age-related susceptibility to severe malaria associated with galectin-2 in highland Papuans.

Journal Article J Infect Dis · July 1, 2010 BACKGROUND: Age and host genetics are important determinants of malaria severity. Lymphotoxin-alpha (LTalpha) has been associated with the development of cerebral malaria (CM) and other severe malaria (SM) syndromes. Mutations in genes regulating LTalpha p ... Full text Link to item Cite

Dynamic loading enhances integrative meniscal repair in the presence of interleukin-1.

Journal Article Osteoarthritis Cartilage · June 2010 Featured Publication OBJECTIVE: Meniscal tears are a common knee injury and increased levels of interleukin-1 (IL-1) have been measured in injured and degenerated joints. Studies have shown that IL-1 decreases the shear strength, cell accumulation, and tissue formation in meni ... Full text Link to item Cite

A single tube, four-color flow cytometry assay for evaluation of ZAP-70 and CD38 expression in chronic lymphocytic leukemia.

Journal Article Am J Clin Pathol · May 2010 We describe a simple and robust flow cytometry assay for ZAP-70 and CD38 expression. The steps required to validate this assay in a clinical flow cytometry laboratory are described. Two criteria were used to characterize ZAP-70 expression into positive, ne ... Full text Link to item Cite

Increased asymmetric dimethylarginine in severe falciparum malaria: association with impaired nitric oxide bioavailability and fatal outcome.

Journal Article PLoS Pathog · April 22, 2010 Featured Publication Asymmetrical dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), is a predictor of mortality in critical illness. Severe malaria (SM) is associated with decreased NO bioavailability, but the contribution of ADMA to the pathogen ... Full text Link to item Cite

Genetic susceptibility variants for chronic lymphocytic leukemia.

Journal Article Cancer Epidemiol Biomarkers Prev · April 2010 BACKGROUND: There is strong and consistent evidence that a genetic component contributes to the etiology of chronic lymphocytic leukemia (CLL). A recent genome-wide association study of CLL identified seven genetic variants that increased the risk of CLL w ... Full text Link to item Cite

Tsukamurella catheter-related bloodstream infection in a pediatric patient with pulmonary hypertension.

Journal Article Infect Dis Rep · February 3, 2010 Catheter-related bloodstream infections (CR-BSI) are important complications in patients with long-term indwelling central venous catheters. In this report, we present the case of a 14-year-old male with pulmonary hypertension treated with continuous trepr ... Full text Link to item Cite

Malaria severity and human nitric oxide synthase type 2 (NOS2) promoter haplotypes.

Journal Article Hum Genet · February 2010 Nitric oxide (NO) mediates host resistance to severe malaria and other infectious diseases. NO production and mononuclear cell expression of the NO producing enzyme-inducible nitric oxide synthase (NOS2) have been associated with protection from severe fal ... Full text Link to item Cite

Single-cell analysis reveals oligoclonality among 'low-count' monoclonal B-cell lymphocytosis.

Journal Article Leukemia · January 2010 Featured Publication Monoclonal B-cell lymphocytosis (MBL) is a preclinical hematologic syndrome characterized by small accumulations of CD5(+) B lymphocytes. Most MBL share phenotypic characteristics with chronic lymphocytic leukemia (CLL). Although some MBL progress to CLL, ... Full text Link to item Cite

Increased asymmetric dimethylarginine in severe falciparum malaria: Association with impaired nitric oxide bioavailability and fatal outcome

Journal Article PLoS Pathogens · 2010 Featured Publication Asymmetrical dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), is a predictor of mortality in critical illness. Severe malaria (SM) is associated with decreased NO bioavailability, but the contribution of ADMA to the pathogen ... Full text Cite

Monoclonal B cell lymphocytosis: clinical and population perspectives.

Journal Article Cytometry B Clin Cytom · 2010 Monoclonal B Cell Lymphocytosis (MBL) refers to clones of CLL-like cells that exhibit CLL characteristics that fall short of the numbers required for CLL diagnosis. Data from large CLL kindreds document increased prevalence of MBL suggesting a genetic cont ... Full text Link to item Cite

The SET Oncogene, a Potent PP2A Inhibitor, Is Elevated in CLL and Antagonism of SET Induces Apoptosis.

Conference Blood · November 20, 2009 AbstractAbstract 802Background and Significance:Even though we have treatments for CLL, it remains an ... Full text Cite

A genomic approach to improve prognosis and predict therapeutic response in chronic lymphocytic leukemia.

Journal Article Clin Cancer Res · November 15, 2009 Featured Publication PURPOSE: Chronic lymphocytic leukemia (CLL) is a B-cell malignancy characterized by a variable clinical course. Several parameters have prognostic capabilities but are associated with altered response to therapy in only a small subset of patients. EXPERIME ... Full text Link to item Cite

Relationship of cell-free hemoglobin to impaired endothelial nitric oxide bioavailability and perfusion in severe falciparum malaria.

Journal Article J Infect Dis · November 15, 2009 BACKGROUND: Hemolysis causes anemia in falciparum malaria, but its contribution to microvascular pathology in severe malaria (SM) is not well characterized. In other hemolytic diseases, release of cell-free hemoglobin causes nitric oxide (NO) quenching, en ... Full text Link to item Cite

NOS2A, TLR4, and IFNGR1 interactions influence pulmonary tuberculosis susceptibility in African-Americans.

Journal Article Hum Genet · November 2009 Tuberculosis (TB) has substantial mortality worldwide with 5-10% of those exposed progressing to active TB disease. Studies in mice and humans indicate that the inducible nitric oxide synthase (iNOS) molecule plays an important role in immune response to T ... Full text Link to item Cite

Effects of allergic airway disease on mouse adenovirus type 1 respiratory infection.

Journal Article Virology · August 15, 2009 Virus infection may contribute to asthma pathogenesis. In turn, a Th2-polarized pulmonary environment may increase host susceptibility to infection. We used a cockroach antigen (CRA) model of allergic airway disease to test the hypothesis that Th2 cytokine ... Full text Link to item Cite

Inhibition of nitric oxide synthase by cobalamins and cobinamides.

Journal Article Free Radic Biol Med · June 15, 2009 Featured Publication Cobalamins are important cofactors for methionine synthase and methylmalonyl-CoA mutase. Certain corrins also bind nitric oxide (NO), quenching its bioactivity. To determine if corrins would inhibit NO synthase (NOS), we measured their effects on -L-[(14)C ... Full text Link to item Cite

Inhibition of matrix metalloproteinases enhances in vitro repair of the meniscus.

Journal Article Clin Orthop Relat Res · June 2009 Damage or injury of the meniscus is associated with onset and progression of knee osteoarthritis (OA). The intrinsic repair capacity of the meniscus is inhibited by inflammatory cytokines, such as interleukin-1 (IL-1). Using an in vitro meniscal repair mod ... Full text Link to item Cite

Patterns of microRNA expression characterize stages of human B-cell differentiation.

Journal Article Blood · May 7, 2009 Mature B-cell differentiation provides an important mechanism for the acquisition of adaptive immunity. Malignancies derived from mature B cells constitute the majority of leukemias and lymphomas. These malignancies often maintain the characteristics of th ... Full text Link to item Cite

Intraprotein electron transfer in inducible nitric oxide synthase holoenzyme.

Journal Article J Biol Inorg Chem · January 2009 Intraprotein electron transfer (IET) from flavin mononucleotide (FMN) to heme is essential in NO synthesis by NO synthase (NOS). Our previous laser flash photolysis studies provided a direct determination of the kinetics of the FMN-heme IET in a truncated ... Full text Link to item Cite

Apolipoprotein E genotype as a determinant of survival in chronic lymphocytic leukemia.

Journal Article Leukemia · December 2008 Survival of chronic lymphocytic leukemia (CLL) cells requires sustained activation of the antiapoptotic PI-3-K/Akt pathway, and many therapies for CLL cause leukemia cell death by triggering apoptosis. Blood lipoprotein particles are either pro- or antiapo ... Full text Link to item Cite

Gammaherpesvirus modulation of mouse adenovirus type 1 pathogenesis.

Journal Article Virology · October 25, 2008 Immune function is likely to be shaped by multiple infections over time. Infection with one pathogen can confer cross-protection against heterologous pathogens. We tested the hypothesis that latent murine gammaherpesvirus 68 (gammaHV68) infection modulates ... Full text Link to item Cite

Arginine, nitric oxide, carbon monoxide, and endothelial function in severe malaria.

Journal Article Curr Opin Infect Dis · October 2008 Featured Publication PURPOSE OF REVIEW: Parasiticidal therapy of severe falciparum malaria improves outcome, but up to 30% of these patients die despite best therapy. Nitric oxide is protective against severe disease, and both nitric oxide and arginine (the substrate for nitri ... Full text Link to item Cite

Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations.

Journal Article J Infect Dis · August 15, 2008 BACKGROUND: Severe malaria is characterized by microvascular obstruction, endothelial dysfunction, and reduced levels of L-arginine and nitric oxide (NO). L-Arginine infusion improves endothelial function in moderately severe malaria. Neither the longitudi ... Full text Link to item Cite

CLL cell apoptosis induced by nitric oxide synthase inhibitors: correlation with lipid solubility and NOS1 dissociation constant.

Journal Article Leuk Res · July 2008 Nitric oxide synthase (NOS) inhibitors induce chronic lymphocytic leukemia (CLL) cell apoptosis and have potential as CLL therapeutics. We determined the half-maximal concentration (ED(50)) of 22 NOS inhibitors that induced CLL cell death in vitro. There w ... Full text Link to item Cite

Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease.

Journal Article Blood · June 15, 2008 Up to 30% of adult patients with sickle cell disease (SCD) will develop pulmonary hypertension (pHTN), a complication associated with significant morbidity and mortality. To identify genetic factors that contribute to risk for pHTN in SCD, we performed ass ... Full text Link to item Cite

Safety profile of L-arginine infusion in moderately severe falciparum malaria.

Journal Article PLoS One · June 11, 2008 BACKGROUND: L-arginine infusion improves endothelial function in malaria but its safety profile has not been described in detail. We assessed clinical symptoms, hemodynamic status and biochemical parameters before and after a single L-arginine infusion in ... Full text Open Access Link to item Cite

Reactive nitrogen and oxygen species in interleukin-1-mediated DNA damage associated with osteoarthritis.

Journal Article Osteoarthritis Cartilage · May 2008 OBJECTIVE: Osteoarthritis (OA) is associated with increased levels of reactive nitrogen and oxygen species and pro-inflammatory cytokines, such as interleukin-1 (IL-1). Nitric oxide (NO) can mediate a number of the catabolic effects of IL-1 in articular ca ... Full text Link to item Cite

Exacerbation of established pulmonary fibrosis in a murine model by gammaherpesvirus.

Journal Article Am J Respir Crit Care Med · April 1, 2008 RATIONALE: Idiopathic pulmonary fibrosis is a progressive disease with high mortality. Although most patients have a slow, progressive course, some patients will have an acute deterioration in function or acute exacerbation, which carries a poor prognosis. ... Full text Link to item Cite

Inhibition of integrative repair of the meniscus following acute exposure to interleukin-1 in vitro.

Journal Article J Orthop Res · April 2008 Damage or loss of the meniscus is associated with progressive osteoarthritic degeneration of the knee joint. Injured and degenerative joints are characterized by elevated levels of the pro-inflammatory cytokine interleukin-1 (IL-1), which with prolonged ex ... Full text Link to item Cite

MAM 2008 Poster Abstracts

Conference International Journal for Parasitology · January 2008 Full text Cite

Clinical and molecular predictors of disease severity and survival in chronic lymphocytic leukemia.

Journal Article Am J Hematol · December 2007 Several parameters may predict disease severity and overall survival in chronic lymphocytic leukemia (CLL). The purpose of our study of 190 CLL patients was to compare immunoglobulin heavy chain variable region (IgV(H)) mutation status, cytogenetic abnorma ... Full text Link to item Cite

A Genomic Strategy To Refine Prognosis and Predict Response to Therapy in Chronic Lymphocytic Leukemia.

Conference Blood · November 16, 2007 AbstractChronic Lymphocytic Leukemia (CLL) is notable for variation in aggressiveness of disease. Many patients with low-risk disease at diagnosis can be followed expectantly, while others rapidly require th ... Full text Cite

Cytotoxicity of the Type 4 Phosphodiesterase Inhibitor CD160130 for Freshly Isolated Human CLL Cells In Vitro.

Conference Blood · November 16, 2007 AbstractB cell chronic lymphocytic leukemia (CLL), the most common subtype of leukemia in the United States of America and in Europe, is treatable but incurable. New drugs are needed for its management. Phos ... Full text Cite

Apolipoprotein E (APOE) Genotype as a Determinant of Survival in Women with Chronic Lymphocytic Leukemia.

Conference Blood · November 16, 2007 AbstractSurvival of CLL cells requires sustained activation of the anti-apoptotic PI-3-kinase/Akt pathway, and many therapies for CLL cause leukemia cell death by triggering apoptosis. Blood lipoprotein part ... Full text Cite

Monoclonal B Cell Lymphocytosis Exhibits Biologic Diversity Similar to Chronic Lymphocytic Leukemia.

Conference Blood · November 16, 2007 AbstractBackground: Monoclonal B cell lymphocytosis (MBL) is a pre-clinical syndrome characterized by small accumulations of monoclonal B lymphocytes in the peripheral blood. MBL have an immunophenotype simi ... Full text Cite

Functional and Numerical T Cell Abnormalities in Chronic Lymphocytic Leukemia.

Conference Blood · November 16, 2007 AbstractBackground: Although most malignancies are associated with decreased numbers of circulating T cells, in CLL they are elevated 2 to 4 times normal. Rather than promoting an anti-tumor response, this i ... Full text Cite

Monoclonal B Cell Lymphocytosis as a Marker of Inherited Predisposition to Chronic Lymphocytic Leukemia.

Conference Blood · November 16, 2007 AbstractBackground: Segregation analyses suggest that CLL has one of the highest inherited risks among all types of cancer. However, no common germline mutations that confer an inherited predisposition to CL ... Full text Cite

Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria.

Journal Article J Exp Med · October 29, 2007 Featured Publication Severe falciparum malaria (SM) is associated with tissue ischemia related to cytoadherence of parasitized erythrocytes to microvascular endothelium and reduced levels of NO and its precursor, l-arginine. Endothelial function has not been characterized in S ... Full text Link to item Cite

Enhanced integrative repair of the porcine meniscus in vitro by inhibition of interleukin-1 or tumor necrosis factor alpha.

Journal Article Arthritis Rheum · September 2007 Featured Publication OBJECTIVE: To examine the hypotheses that increasing concentrations of interleukin-1 (IL-1) or tumor necrosis factor alpha (TNFalpha) inhibit the integrative repair of the knee meniscus in an in vitro model system, and that inhibitors of these cytokines wi ... Full text Link to item Cite

Interleukin-1 and tumor necrosis factor alpha inhibit repair of the porcine meniscus in vitro.

Journal Article Osteoarthritis Cartilage · September 2007 OBJECTIVE: Injury or removal of the knee meniscus leads to progressive joint degeneration, and current surgical therapies for meniscal tears seek to maximally preserve meniscal structure and function. However, the factors that influence intrinsic repair of ... Full text Link to item Cite

Regional differences in prostaglandin E2 and nitric oxide production in the knee meniscus in response to dynamic compression.

Journal Article Biochem Biophys Res Commun · July 13, 2007 Injury or loss of the knee meniscus is associated with altered joint stresses that lead to progressive joint degeneration. The goal of this study was to determine if dynamic mechanical compression influences the production of inflammatory mediators by meni ... Full text Link to item Cite

A specific PDE-4 inhibitor as an inductor of apoptosis in B-CLL

Journal Article DRUGS OF THE FUTURE · July 1, 2007 Link to item Cite

Higher production of peripheral blood macrophage migration inhibitory factor in healthy children with a history of mild malaria relative to children with a history of severe malaria.

Journal Article The American journal of tropical medicine and hygiene · June 2007 Plasmodium falciparum malaria is one of the leading causes of childhood morbidity and mortality in sub-Saharan Africa. The host immune response to P. falciparum is a critical determinant of malarial pathogenesis and disease outcomes. Macrophage migration i ... Cite

Higher production of peripheral blood macrophage migration inhibitory factor in healthy children with a history of mild malaria relative to children with a history of severe malaria.

Journal Article Am J Trop Med Hyg · June 2007 Plasmodium falciparum malaria is one of the leading causes of childhood morbidity and mortality in sub-Saharan Africa. The host immune response to P. falciparum is a critical determinant of malarial pathogenesis and disease outcomes. Macrophage migration i ... Link to item Cite

Repair response of the inner and outer regions of the porcine meniscus in vitro.

Journal Article Am J Sports Med · May 2007 BACKGROUND: The menisci are essential intra-articular structures that contribute to knee function, and meniscal injury or loss is associated with joint degeneration. Tears of the outer vascularized zone have a greater potential for repair than do tears in ... Full text Link to item Cite

Genetic polymorphisms associated with priapism in sickle cell disease.

Journal Article Br J Haematol · May 2007 Priapism occurs in 30-45% of male patients with sickle cell disease (SCD), but the possible influence of genetic risk factors on the incidence of priapism is not well understood. We examined genetic polymorphisms in 199 unrelated, adult (>18 years), male p ... Full text Link to item Cite

Oxygen, nitric oxide and articular cartilage.

Journal Article Eur Cell Mater · April 11, 2007 Molecular oxygen is required for the production of nitric oxide (NO), a pro-inflammatory mediator that is associated with osteoarthritis and rheumatoid arthritis. To date there has been little consideration of the role of oxygen tension in the regulation o ... Full text Link to item Cite

Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification.

Journal Article Blood · February 15, 2007 Somatic mutations of immunoglobulin genes characterize mature memory B cells, and intraclonal B-cell diversification is typically associated with expansion of B-cell clones with greater affinity for antigen (antigen drive). Evidence for a role of antigen i ... Full text Link to item Cite

Lipopolysaccharide O-antigen promotes persistent murine bacteremia.

Journal Article Shock · February 2007 Bacteremia is a common complication of pneumonia with Klebsiella pneumoniae. In the previous work, we have shown that the lipopolysaccharide (LPS) O-antigen in K. pneumoniae O1:K2 contributes to lethality during pneumonia in part by promoting bacteremia. I ... Full text Link to item Cite

Influence of oxygen tension on interleukin 1-induced peroxynitrite formation and matrix turnover in articular cartilage.

Journal Article J Rheumatol · February 2007 OBJECTIVE: Osteoarthritis is characterized by the degradation of articular cartilage. The catabolic activity of chondrocytes is partly regulated by nitric oxide (NO), which with superoxide (O2-) leads to the formation of peroxynitrite (OONO-), a potentiall ... Link to item Cite

Burkholderia glumae infection in an infant with chronic granulomatous disease.

Journal Article J Clin Microbiol · February 2007 An 8-month-old boy developed a necrotic lung mass from which Burkholderia glumae was recovered, leading to the diagnosis of chronic granulomatous disease (CGD). While other Burkholderia species have been identified as important pathogens in persons with CG ... Full text Link to item Cite

Contributions of E1A to mouse adenovirus type 1 pathogenesis following intranasal inoculation.

Journal Article Virology · January 5, 2007 We investigated the role of mouse adenovirus type 1 (MAV-1) early region 1A (E1A) protein in adenovirus respiratory infection. Intranasal (i.n.) inoculation of mice with wild type (wt) virus induced chemokine and cellular inflammatory responses in the lung ... Full text Link to item Cite

Nitric oxide synthase and cyclooxygenase interactions in cartilage and meniscus: relationships to joint physiology, arthritis, and tissue repair.

Journal Article Subcell Biochem · 2007 Featured Publication Rheumatoid arthritis and osteoarthritis are painful and debilitating diseases with complex pathophysiology. There is growing evidence that pro-inflammatory cytokines (e.g., interleukin-1 and tumor necrosis factor alpha) and mediators (e.g., prostaglandins, ... Full text Link to item Cite

The effects of pro-inflammatory cytokines on functional repair of the meniscus

Journal Article MCB Molecular and Cellular Biomechanics · December 1, 2006 A study was performed to examine the hypotheses that increasing concentrations of the pro-inflammatory cytokines interleukin-1 (IL-1) or tumor necrosis factor-alpha (TNF) inhibit integrative repair of the knee meniscus in an in vitro model system and that ... Cite

NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease.

Journal Article Proc Natl Acad Sci U S A · August 22, 2006 Alzheimer's disease is characterized by two primary pathological features: amyloid plaques and neurofibrillary tangles. The interconnection between amyloid and tau aggregates is of intense interest, but mouse models have yet to reveal a direct interrelatio ... Full text Link to item Cite

Oxygen, nitric oxide, and osteoarthritis

Journal Article European Cells and Materials · August 1, 2006 Cite

Elevated plasma phenylalanine in severe malaria and implications for pathophysiology of neurological complications.

Journal Article Infect Immun · June 2006 Cerebral malaria is associated with decreased production of nitric oxide and decreased levels of its precursor, l-arginine. Abnormal amino acid metabolism may thus be an important factor in malaria pathogenesis. We sought to determine if other amino acid a ... Full text Link to item Cite

Nitric-oxide synthase output state. Design and properties of nitric-oxide synthase oxygenase/FMN domain constructs.

Journal Article J Biol Chem · May 19, 2006 Mammalian nitric-oxide synthases are large modular enzymes that evolved from independently expressed ancestors. Calmodulin-controlled isoforms are signal generators; calmodulin activates electron transfer from NADPH through three reductase domains to an ox ... Full text Link to item Cite

Suppression of prostaglandin E2 by malaria parasite products and antipyretics promotes overproduction of tumor necrosis factor-alpha: association with the pathogenesis of childhood malarial anemia.

Journal Article J Infect Dis · May 15, 2006 Cytokines and effector molecules are important immunoregulatory molecules in human malaria. Tumor necrosis factor (TNF)-alpha limits malaria parasitemia but also promotes pathogenesis at high concentrations, whereas prostaglandin E2 (PGE2) inhibits TNF-alp ... Full text Link to item Cite

Decreased circulating macrophage migration inhibitory factor (MIF) protein and blood mononuclear cell MIF transcripts in children with Plasmodium falciparum malaria.

Journal Article Clin Immunol · May 2006 Plasmodium falciparum malaria remains one of the most frequently lethal diseases affecting children in sub-Saharan Africa, yet the immune mediators that regulate pathogenesis are only partially defined. Since macrophage migration inhibitory factor (MIF) is ... Full text Link to item Cite

Chronic lymphocytic leukemia cell CD38 expression and inducible nitric oxide synthase expression are associated with serum IL-4 levels.

Journal Article Leuk Res · January 2006 B cell chronic lymphocytic leukemia (CLL) CD38 expression is variable and may predict outcome. Inducible nitric oxide synthase (NOS2) expression regulates CLL cell apoptosis. IL-4 and IFN-gamma regulate B cell CD38 expression and NOS2 expression. We compar ... Full text Link to item Cite

Biaxial strain effects on cells from the inner and outer regions of the meniscus.

Journal Article Connect Tissue Res · 2006 During knee joint loading, the fibrocartilaginous menisci experience significant spatial variations in mechanical stimuli. Meniscus cells also exhibit significant variations in biosynthesis and gene expression depending on their location within the tissue. ... Full text Link to item Cite

Serum, urinary, and salivary nitric oxide in rheumatoid arthritis: complexities of interpreting nitric oxide measures.

Journal Article Arthritis Res Ther · 2006 Nitric oxide (NO) may play important roles in rheumatoid arthritis (RA). RA is an inflammatory disease involving joints and other systems including salivary glands. To assess NO production in RA patients, we compared levels of serum, urine, and salivary ni ... Full text Link to item Cite

Patterns of gene expression that characterize outcomes of Plasmodium falciparum infection

Journal Article AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE · December 1, 2005 Link to item Cite

Cobalamins and Cobinamides Inhibit Nitric Oxide Synthase Enzymatic Activity.

Conference Blood · November 16, 2005 AbstractCobalamins (Cbl) serve as important co-factors for methionine synthase and methylmalonyl-coA mutase. They also can block the activities of nitric oxide (NO), as the cobalt binds NO and quenches its b ... Full text Cite

The influence of oxygen tension on the induction of nitric oxide and prostaglandin E2 by mechanical stress in articular cartilage.

Journal Article Osteoarthritis Cartilage · October 2005 OBJECTIVES: Articular cartilage is an avascular tissue that exists at low oxygen tension. Oxygen tension can influence the production of the pro-inflammatory mediators nitric oxide (NO) and prostaglandin E2 (PGE(2)) in cartilage, which are increased in ost ... Full text Link to item Cite

Acute respiratory infection with mouse adenovirus type 1.

Journal Article Virology · September 30, 2005 Studies of the pathogenesis of adenovirus respiratory disease are limited by the strict species-specificity of the adenoviruses. Following intranasal inoculation of adult C57BL/6 mice with mouse adenovirus type 1 (MAV-1), we detected MAV-1 early region 3 ( ... Full text Link to item Cite

Differential regulation of beta-chemokines in children with Plasmodium falciparum malaria.

Journal Article Infect Immun · July 2005 Chemokines regulate the host immune response to a variety of infectious pathogens. Since the role of chemokines in regulating host immunity in children with Plasmodium falciparum malaria has not previously been reported, circulating levels of beta-chemokin ... Full text Link to item Cite

p47 GTPases regulate Toxoplasma gondii survival in activated macrophages.

Journal Article Infect Immun · June 2005 The cytokine gamma interferon (IFN-gamma) is critical for resistance to Toxoplasma gondii. IFN-gamma strongly activates macrophages and nonphagocytic host cells to limit intracellular growth of T. gondii; however, the cellular factors that are required for ... Full text Link to item Cite

Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production.

Journal Article J Biol Chem · May 13, 2005 One of the phenotypes of mice with targeted disruption of the uncoupling protein-2 gene (Ucp2-/-) is greater macrophage phagocytic activity and free radical production, resulting in a striking resistance to infectious microorganisms. In this study, the mol ... Full text Link to item Cite

Impaired systemic production of prostaglandin E2 in children with cerebral malaria.

Journal Article J Infect Dis · May 1, 2005 Prostaglandins (PGs) are important mediators of macrophage activity, vascular permeability, fever, erythropoiesis, and proinflammatory responses to infection. Our recent studies have shown that plasma levels of bicyclo-PGE2 (a stable end product of PGE2 me ... Full text Link to item Cite

Gammaherpesvirus-induced lung pathology is altered in the absence of macrophages.

Journal Article Lung · 2005 The purpose of this study was to examine the lung pathogenesis of murine gammaherpesvirus (MHV-68) infection in mice that lack CC chemokine receptor CCR2, an important receptor for macrophage recruitment to sites of inflammation. BALB/c and CCR2(-/-) mice ... Full text Link to item Cite

Nitric oxide production and nitric oxide synthase activity in malaria-exposed Papua New Guinean children and adults show longitudinal stability and no association with parasitemia.

Journal Article Infect Immun · December 2004 Individuals in areas of intense malaria transmission exhibit resistance (or tolerance) to levels of parasitemia in their blood that would normally be associated with febrile illness in malaria-naive subjects. The resulting level of parasitemia associated w ... Full text Link to item Cite

The effects of cyclic mechanical strain and tumor necrosis factor alpha on the response of cells of the meniscus.

Journal Article Osteoarthritis Cartilage · December 2004 OBJECTIVES: Cells of the knee meniscus respond to changes in their biochemical and biomechanical environments with alterations in the biosynthesis of matrix constituents and inflammatory mediators. Tumor necrosis factor alpha (TNF-alpha) is a pro-inflammat ... Full text Link to item Cite

The dichotomous role of nitric oxide in the pathogenesis of accelerated atherosclerosis associated with systemic lupus erythematosus.

Journal Article Curr Mol Med · November 2004 Atherosclerosis is an inflammatory disorder, and the inflammation associated with systemic lupus erythematosus (SLE) accelerates the development of atherosclerosis. Nitric oxide (NO) is an important mediator of inflammation including the inflammation assoc ... Full text Link to item Cite

Oxygen, mechanical compression and inflammation in articular cartilage.

Conference JOURNAL OF BONE AND MINERAL RESEARCH · October 1, 2004 Link to item Cite

Differential activation of nitric-oxide synthase isozymes by calmodulin-troponin C chimeras.

Journal Article J Biol Chem · August 6, 2004 The interactions of neuronal nitric-oxide synthase (nNOS) with calmodulin (CaM) and mutant forms of CaM, including CaM-troponin C chimeras, have been previously reported, but there has been no comparable investigation of CaM interactions with the other con ... Full text Link to item Cite

Elevated nitric oxide production in children with malarial anemia: hemozoin-induced nitric oxide synthase type 2 transcripts and nitric oxide in blood mononuclear cells.

Journal Article Infect Immun · August 2004 Experiments outlined here investigate the role of nitric oxide (NO) in the pathogenesis of Plasmodium falciparum-induced malarial anemia (MA). The results show that ex vivo and in vitro NO synthase (NOS) activity in peripheral blood mononuclear cells (PBMC ... Full text Link to item Cite

The role of biomechanics and inflammation in cartilage injury and repair.

Journal Article Clin Orthop Relat Res · June 2004 Osteoarthritis is a painful and debilitating disease characterized by progressive degenerative changes in the articular cartilage and other joint tissues. Biomechanical factors play a critical role in the initiation and progression of this disease, as evid ... Full text Link to item Cite

Thermodynamics of oxidation-reduction reactions in mammalian nitric-oxide synthase isoforms.

Journal Article J Biol Chem · April 30, 2004 The three mammalian nitric-oxide synthases produce NO from arginine in a reaction requiring 3 electrons per NO, which are supplied to the catalytic center from NADPH through reductase domains incorporating FAD and FMN cofactors. The isoforms share a common ... Full text Link to item Cite

Mouse strain differences in the chemokine response to acute lung infection with a murine gammaherpesvirus.

Journal Article Viral Immunol · 2004 Numerous mouse strain-based differences in the immune response and in susceptibility to numerous pathogens have been described, but it is not known if these differences extend to chemokine responses to viral infection of the lungs. To define mouse strain-b ... Full text Link to item Cite

Reduced peripheral PGE2 biosynthesis in Plasmodium falciparum malaria occurs through hemozoin-induced suppression of blood mononuclear cell cyclooxygenase-2 gene expression via an interleukin-10-independent mechanism.

Journal Article Mol Med · 2004 Molecular immunologic determinants of disease severity during Plasmodium falciparum malaria are largely undetermined. Our recent investigations showed that peripheral blood mononuclear cell (PBMC) cyclooxygenase-2 (COX-2) gene expression and plasma prostag ... Full text Link to item Cite

Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population.

Journal Article Am J Trop Med Hyg · December 2003 Polymorphisms in the inducible nitric oxide synthase gene (NOS2) promoter have been associated with clinical outcome from malaria. These include a CCTTT repeat (CCTTTn) 2.5 kilobases upstream from the NOS2 transcription start site, and two single nucleotid ... Link to item Cite

Plasma interleukin-12 in malaria-tolerant papua new guineans: inverse correlation with Plasmodium falciparum parasitemia and peripheral blood mononuclear cell nitric oxide synthase activity.

Journal Article Infect Immun · November 2003 Interleukin-12 (IL-12) has been inversely associated with disease severity in human and murine malaria, and a polymorphism in the IL-12 p40 subunit gene (IL12B) has been associated with susceptibility to human cerebral malaria and reduced nitric oxide (NO) ... Full text Link to item Cite

Nitric oxide production and mononuclear cell nitric oxide synthase activity in malaria-tolerant Papuan adults.

Journal Article Infect Immun · July 2003 Individuals living in regions of intense malaria transmission exhibit natural immunity that allows them to be without fever and other symptoms for most of the time despite frequent parasitization. Although this tolerance of parasitemia appears to be more e ... Full text Link to item Cite

Regulation of matrix turnover in meniscal explants: role of mechanical stress, interleukin-1, and nitric oxide.

Journal Article J Appl Physiol (1985) · July 2003 The meniscus is an intra-articular fibrocartilaginous structure that serves essential biomechanical roles in the knee. With injury or arthritis, the meniscus may be exposed to significant changes in its biochemical and biomechanical environments that likel ... Full text Link to item Cite

Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production.

Journal Article Lancet · February 22, 2003 Nitric oxide (NO) production and mononuclear cell NO synthase 2 (NOS2) expression are high in healthy Tanzanian children but low in those with cerebral malaria. Factors that downregulate NOS2 also diminish factors involved in cellular uptake and biosynthes ... Full text Link to item Cite

IL-4 and interferon gamma regulate expression of inducible nitric oxide synthase in chronic lymphocytic leukemia cells.

Journal Article Leukemia · February 2003 Chronic lymphocytic leukemia (B-CLL) is characterized by the accumulation of long-lived non-dividing CD5(+) B cells. Nitric oxide (NO) is an important regulator of apoptosis, and the viability of cultured B-CLL cells may be dependent on the autocrine produ ... Full text Link to item Cite

Case report of Staphylococcus aureus endocarditis after navel piercing.

Journal Article Pediatr Infect Dis J · January 2003 A 13-year-old girl with surgically corrected congenital heart disease presented with a 3-day history of fever 1 month after piercing her navel. An echocardiogram demonstrated a vegetation within her right ventricle to pulmonary artery conduit, and several ... Full text Link to item Cite

Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in african-americans.

Journal Article J Rheumatol · January 2003 OBJECTIVE: Systemic lupus erythematosus (SLE) is an autoimmune disease in which morbidity and mortality are higher in African-Americans. The etiology of this racial disparity is unknown. A genetic predisposition to enhanced nitric oxide (NO) production may ... Link to item Cite

A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children.

Journal Article Lancet · November 9, 2002 BACKGROUND: Nitric oxide (NO) is a mediator of immunity to malaria, and genetic polymorphisms in the promoter of the inducible NO synthase gene (NOS2) could modulate production of NO. We postulated that NOS2 promoter polymorphisms would affect resistance t ... Full text Link to item Cite

A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production.

Journal Article Genes Immun · November 2002 Interleukin-12 (IL-12) is an important regulatory cytokine in infection and immunity. Administration of IL-12 may reduce complications of severe malaria in rodents. Polymorphisms in IL12B, the gene encoding the IL-12 p40 subunit, influence the secretion of ... Full text Link to item Cite

Elevated chemokine responses are maintained in lungs after clearance of viral infection.

Journal Article J Virol · October 2002 We observed two patterns of chemokine expression in the lungs of mice infected with murine gammaherpesvirus 68: peaks of chemokine expression correlated with or occurred after the peak of viral gene expression. Chemokine expression remained elevated throug ... Full text Link to item Cite

Induction of cyclooxygenase-2 by mechanical stress through a nitric oxide-regulated pathway.

Journal Article Osteoarthritis Cartilage · October 2002 OBJECTIVE: Biomechanical signals play important roles in regulating the homeostasis of articular cartilage, but under abnormal conditions may be a critical factor in the onset and progression of arthritis. Prostaglandin E(2) (PGE(2)) and nitric oxide (NO), ... Full text Link to item Cite

Immunity to malaria after administration of ultra-low doses of red cells infected with Plasmodium falciparum.

Journal Article Lancet · August 24, 2002 BACKGROUND: The ability of T cells, acting independently of antibodies, to control malaria parasite growth in people has not been defined. If such was shown to be effective, an additional vaccine strategy could be pursued. Our aim was to ascertain whether ... Full text Link to item Cite

Influence of hypoxia and reoxygenation on cytokine-induced production of proinflammatory mediators in articular cartilage.

Journal Article Arthritis Rheum · April 2002 OBJECTIVE: Articular cartilage is an avascular tissue that functions at a lower oxygen tension than do most tissues. With mobilization, arthritic joints may undergo cycles of hypoxia and reoxygenation. The goal of this study was to determine the effects of ... Full text Link to item Cite

Inducible nitric oxide synthase expression by peritoneal macrophages in endometriosis-associated infertility.

Journal Article Fertil Steril · January 2002 OBJECTIVE: Determine whether peritoneal macrophages from women with endometriosis-associated infertility express more inducible nitric oxide synthase (NOS2) and produce more NO than fertile controls. DESIGN: Unblinded clinical study. PATIENT(S): Nine infer ... Full text Link to item Cite

Nitric oxide enhancement of fludarabine cytotoxicity for B-CLL lymphocytes.

Journal Article Leukemia · December 2001 Fludarabine is active but not curative in the treatment of chronic lymphocytic leukemia (B-CLL). Nitric oxide (NO) supplied from exogenous, NO-donating pro-drugs can also induce apoptosis and death of acute leukemia cells. This study investigated combinati ... Full text Link to item Cite

Host response to infection: the role of CpG DNA in induction of cyclooxygenase 2 and nitric oxide synthase 2 in murine macrophages.

Journal Article Infect Immun · December 2001 Depending on sequence, bacterial and synthetic DNAs can activate the host immune system and influence the host response to infection. The purpose of this study was to determine the abilities of various phosphorothioate oligonucleotides with cytosine-guanos ... Full text Link to item Cite

Interleukin-1, tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci.

Journal Article Arthritis Rheum · September 2001 OBJECTIVE: In osteoarthritis (OA), a combination of biochemical and biomechanical factors may damage both menisci and articular cartilage. Nitric oxide (NO) and prostaglandin E2 (PGE2) have been implicated as mediators of inflammation in OA. The goals of t ... Full text Link to item Cite

Characterization of key residues in the subdomain encoded by exons 8 and 9 of human inducible nitric oxide synthase: a critical role for Asp-280 in substrate binding and subunit interactions.

Journal Article Proc Natl Acad Sci U S A · August 28, 2001 Human inducible nitric oxide synthase (iNOS) is active as a dimer of two identical subunits. Each subunit has an amino-terminal oxygenase domain that binds the substrate l-Arg and the cofactors heme and tetrahydrobiopterin and a carboxyl-terminal reductase ... Full text Link to item Cite

Nitric oxide synthase 2(Lambaréné) (G-954C), increased nitric oxide production, and protection against malaria.

Journal Article J Infect Dis · August 1, 2001 A point mutation in the promoter of the nitric oxide synthase 2 gene (NOS2), termed NOS2(Lambaréné) (NOS2-G954C), protects heterozygous carriers against severe malaria as effectively as the sickle cell trait. In a prospective longitudinal study, 841 indivi ... Full text Link to item Cite

Mechanical stress and nitric oxide influence leukotriene production in cartilage.

Journal Article Biochem Biophys Res Commun · July 20, 2001 Nitric oxide (NO) and leukotrienes regulate a variety of processes in joint tissues and are frequently elevated in arthritis. Mechanical stress can induce biochemical and functional changes in cartilage that may influence mediator production. To investigat ... Full text Link to item Cite

The effects of static and intermittent compression on nitric oxide production in articular cartilage explants.

Journal Article J Orthop Res · July 2001 Nitric oxide (NO) production and NO synthase (NOS) expression are increased in osteoarthritis and rheumatoid arthritis, suggesting that NO may play a role in the destruction of articular cartilage. To test the hypothesis that mechanical stress may increase ... Full text Link to item Cite

The effect of dynamic mechanical compression on nitric oxide production in the meniscus.

Journal Article Osteoarthritis Cartilage · July 2001 OBJECTIVE: The menisci play an important role in the biomechanics of the knee, and loss of meniscal function has been associated with progressive degenerative changes of the joint in rheumatoid arthritis as well as in osteoarthritis. However, little is kno ... Full text Link to item Cite

Inverse relationship of plasma prostaglandin E2 and blood mononuclear cell cyclooxygenase-2 with disease severity in children with Plasmodium falciparum malaria.

Journal Article J Infect Dis · January 1, 2001 Prostaglandins (PGs) derived from inducible cyclooxygenase (COX)-2 are important proinflammatory mediators of the host-immune response to infection. Since the role of host-derived PG in human malaria is unknown, plasma bicyclo-PGE2 (a stable catabolite of ... Full text Link to item Cite

A review of polymorphisms in the human gene for inducible nitric oxide synthase (NOS2) in patients with malaria

Journal Article Sepsis · January 1, 2001 Significant variability exists in host responses to malaria in different human populations. These epidemiological data have prompted a search for genetic variations that determine host responses to malaria. This review focuses on polymorphisms in the promo ... Full text Cite

Inverse relationship of plasma prostaglandin-E2 and blood mononuclear cell cyclooxygenase-2 with disease severity in children with plasmodium falciparum malaria

Journal Article Blood · December 1, 2000 Prostaglandins (PG) derived from inducible cyclooxygenase (COX-2) are important pro-inflammatory mediators of the host-immune response to infection. Since the role of host-derived PG in human malaria is unknown, plasma bicyclo-PGE2 (a stable catabolite of ... Cite

Cytokine regulation of inducffile nitric oxide synthase (nos2) and nos2 inhibitor-induced apoptosis and death in chronic lymphocytic leukemia cells

Journal Article Blood · December 1, 2000 Chronic lymphocytic leukemia (B-CLL) is a malignancy of a mantle zone-based subpopulation of anergic, self-reactive, activated CD5+ B lymphocytes devoted to the production of polyreactive natural autoantibodies. B-CLL is characterized by the accumulation o ... Cite

Nitric oxide asa nonprotein regulator of hematopoietic cell proliferation and differentiation-relationship to malarial anemia

Journal Article Blood · December 1, 2000 Malaria is extremely important, with approximately 500 million people infected and 1.5 to 2.7 million dying from the disease each year. Deaths are usually related to cerebral malaria and malarial anemia. Malarial anemia is a multifactorial anemia related t ... Cite

Peroxynitrite formation and decreased catalase activity in autoimmune MRL-lpr/lpr mice.

Journal Article Mol Med · September 2000 BACKGROUND: (MRL)-lpr/lpr mice spontaneously develop autoimmune disease characterized by arthritis and glomerulonephritis. Nitric oxide is postulated to play a role in the disease pathogenesis, as mice treated with the nitric oxide synthase inhibitor N(G)- ... Link to item Cite

Reduced interleukin-12 and transforming growth factor-beta1 in severe childhood malaria: relationship of cytokine balance with disease severity.

Journal Article J Infect Dis · September 2000 Interleukin (IL)-12 and transforming growth factor (TGF)-beta1 regulate the balance between pro- and anti-inflammatory cytokines in animal models of malaria. Since the cytokine balance may be an important determinant of whether a protective or a pathogenic ... Full text Link to item Cite

Low interleukin-12 activity in severe Plasmodium falciparum malaria.

Journal Article Infect Immun · July 2000 We compared interleukin-12 (IL-12) and other cytokine activities during and after an acute clinical episode in a matched-pair case-control study of young African children who presented with either mild or severe Plasmodium falciparum malaria. The acute-pha ... Full text Link to item Cite

Reply

Journal Article Arthritis & Rheumatism · May 2000 Full text Cite

Nitric oxide synthase 2 and cyclooxygenase 2 interactions in inflammation.

Journal Article Immunol Res · 2000 Nitric oxide (NO) and prostaglandin (PG) E2 produced by NO synthase type 2 (NOS2) and cyclooxygenase type 2 (COX2), respectively, are important mediators in inflammation. There is much information regarding their roles in models of inflammation in mice and ... Full text Link to item Cite

Nitric oxide synthase type 2 promoter polymorphisms, nitric oxide production, and disease severity in Tanzanian children with malaria.

Journal Article J Infect Dis · December 1999 Nitric oxide (NO) plays an important role in host resistance to infection with a variety of organisms. Two recent reports from Gabon and Gambia identified associations of malaria disease severity with the inducible NO synthase (NOS2) promoter G-954C and sh ... Full text Link to item Cite

Blood mononuclear cell nitric oxide production and plasma cytokine levels in healthy gabonese children with prior mild or severe malaria.

Journal Article Infect Immun · September 1999 Plasmodium falciparum malaria is an important cause of morbidity and mortality in children. Factors that determine the development of mild versus severe malaria are not fully understood. Since host-derived nitric oxide (NO) has antiplasmodial properties, w ... Full text Link to item Cite

Nitric oxide, malaria, and anemia: inverse relationship between nitric oxide production and hemoglobin concentration in asymptomatic, malaria-exposed children.

Journal Article Am J Trop Med Hyg · August 1999 The cause of the anemia associated with chronic, intermittent, asymptomatic, low-level parasitemia in children in malaria-endemic endemic areas is not well understood. Nitric oxide (NO) decreases erythropoiesis, and it is likely an important mediator of an ... Full text Link to item Cite

Effects of age and parasitemia on nitric oxide production/leukocyte nitric oxide synthase type 2 expression in asymptomatic, malaria-exposed children.

Journal Article Am J Trop Med Hyg · August 1999 Age appears to influence not only the acquisition of clinical immunity to malaria but also the susceptibility to and clinical manifestations of severe malaria. Asymptomatic malaria-exposed Tanzanian children have high production of nitric oxide (NO) and un ... Full text Link to item Cite

Interferon-beta1A-induced polyarthritis in a patient with the HLA-DRB1*0404 allele.

Journal Article Arthritis Rheum · March 1999 Human interferon-alpha (IFNalpha) and IFNbeta are administered for treatment of several diseases, including viral infections, malignancies, and multiple sclerosis (MS). IFNalpha therapy has been associated with the production of autoantibodies and the deve ... Full text Link to item Cite

Reduction of NOS2 overexpression in rheumatoid arthritis patients treated with anti-tumor necrosis factor alpha monoclonal antibody (cA2).

Journal Article Arthritis Rheum · December 1998 OBJECTIVE: Peripheral blood mononuclear cells (PBMC) from patients with rheumatoid arthritis (RA) have increased expression of nitric oxide synthase type 2 (NOS2) protein and enhanced formation of nitric oxide (NO) that correlate with disease activity. NO ... Full text Link to item Cite

Nitric oxide as an inflammatory mediator in autoimmune MRL-lpr/lpr mice.

Journal Article Environ Health Perspect · October 1998 Nitric oxide (.NO) may exhibit proinflammatory features. .NO synthase type 2 (NOS2) is overexpressed and .NO overproduced in rodent models of induced inflammation. Blockage of .NO production by administration of NOS inhibitors prevents or reduces various t ... Full text Link to item Cite

Schedule and concentration-dependent induction of apoptosis in leukemia cells by nitric oxide.

Journal Article Leukemia · September 1998 Nitric oxide (NO) has potent antiproliferative properties. In previous work we have shown that NO inhibits growth, induces differentiation and modulates gene expression in acute nonlymphocytic leukemia (ANLL) cells. The goal of this work was to determine w ... Full text Link to item Cite

Cobalamin inhibition of HIV-1 integrase and integration of HIV-1 DNA into cellular DNA.

Journal Article Biochem Biophys Res Commun · May 19, 1998 Our prior studies showed that certain cobalamins inhibit productive HIV-1 infection of primary cultures of blood lymphocytes and monocytes. We demonstrate here that this antiviral activity may be mediated by an inhibition of HIV-1 integrase, an enzyme requ ... Full text Link to item Cite

Nitrosylation of blood hemoglobin and renal nonheme proteins in autoimmune MRL-lpr/lpr mice.

Journal Article Free Radic Biol Med · January 1, 1998 MRL-lpr/lpr mice spontaneously develop manifestations of autoimmunity including arthritis, vasculitis, and glomerulonephritis. The paramagnetic molecule nitric oxide has been implicated as an effector molecule in initiation and propagation of these inflamm ... Full text Link to item Cite

Interferon (IFN)-alpha activation of human blood mononuclear cells in vitro and in vivo for nitric oxide synthase (NOS) type 2 mRNA and protein expression: possible relationship of induced NOS2 to the anti-hepatitis C effects of IFN-alpha in vivo.

Journal Article J Exp Med · November 3, 1997 Although researchers have noted high level activation of rodent mononuclear phagocytes for nitric oxide (NO) synthase type 2 (S2) expression and NO production with a variety of agents such as interferon (IFN) gamma and endotoxin, it has been difficult to d ... Full text Link to item Cite

Clinical and serologic manifestations of autoimmune disease in MRL-lpr/lpr mice lacking nitric oxide synthase type 2.

Journal Article J Exp Med · August 4, 1997 Nitric oxide (NO) is an important mediator of the inflammatory response. MRL-lpr/lpr mice overexpress inducible nitric oxide synthase (NOS2) and overproduce NO in parallel with the development of an autoimmune syndrome with a variety of inflammatory manife ... Full text Link to item Cite

Identification of a synthetic peptide that mimics an HIV glycoprotein 120 envelope conformational determinant exposed following ligation of glycoprotein 120 by CD4.

Journal Article AIDS Res Hum Retroviruses · May 20, 1997 CD4 ligation of HIV envelope gp120 results in conformational changes in gp120 that lead to exposure of the gp41 fusogenic domain and fusion with the host cell membrane. One determinant at or near the CD4-binding site exposed on gp120 subsequent to CD4 bind ... Full text Link to item Cite

Secretory leukocyte protease inhibitor blocks infectivity of primary monocytes and mononuclear cells with both monocytotropic and lymphocytotropic strains of human immunodeficiency virus type I.

Journal Article Oral Dis · May 1997 Saliva contains factors that inhibit infection with the human immunodeficiency virus type 1 (HIV-1) in vitro. One of these factors was recently identified as secretory leukocyte protease inhibitor (SLPI), a salivary protein which blocked HIV-1 infectivity ... Full text Link to item Cite

Nitrate levels in malaria.

Journal Article Trans R Soc Trop Med Hyg · 1997 Full text Link to item Cite

Inhibitory of HIV by secretory leukocyte protein inhibitor.

Journal Article JOURNAL OF DENTAL RESEARCH · January 1, 1997 Link to item Cite

Nitric oxide interactions with cobalamins: biochemical and functional consequences.

Journal Article Blood · September 1, 1996 Nitric oxide (NO) is a paramagnetic gas that has been implicated in a wide range of biologic functions. The common pathway to evoke the functional response frequently involves the formation of an iron-nitrosyl complex in a target (heme) protein. In this st ... Link to item Cite

Increased expression of blood mononuclear cell nitric oxide synthase type 2 in rheumatoid arthritis patients.

Journal Article J Exp Med · September 1, 1996 Nitric oxide (NO) is an important inflammatory mediator in nonhuman animal models of rheumatoid arthritis (RA). The purpose of the present study was to determine whether blood mononuclear cells from patients with active RA (as compared to control subjects) ... Full text Link to item Cite

Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression.

Journal Article J Exp Med · August 1, 1996 Nitric oxide (NO)-related activity has been shown to be protective against Plasmodium falciparum in vitro. It has been hypothesized, however, that excess NO production contributes to the pathogenesis of cerebral malaria. The purpose of this study was to co ... Full text Link to item Cite

Potent inhibition of HIV type 1 infection of mononuclear phagocytes by synthetic peptide analogs of HIV type 1 protease substrates.

Journal Article AIDS Res Hum Retroviruses · June 10, 1996 The HIV-1 genome encodes a protease that is required for viral processing of the precursor polyproteins Pr55gag and Pr160gag-pol. Interference with this process in human lymphocytes inhibits production of infectious virus. We tested the ability of several ... Full text Link to item Cite

Differential effects of nitric oxide on erythroid and myeloid colony growth from CD34+ human bone marrow cells.

Journal Article Blood · February 1, 1996 Nitric oxide (NO) is a reactive molecule with numerous physiologic and pathophysiologic roles affecting the nervous, cardiovascular, and immune systems. In previous work, we have demonstrated that NO inhibits the growth and induces the monocytic differenti ... Link to item Cite

Update on the issues of HIV vaccine development.

Journal Article Ann Med · February 1996 Major scientific obstacles blocking the development of a successful preventive HIV vaccine are the extraordinary variability of HIV, the lack of an exact animal model of HIV-induced AIDS, and the lack of understanding of the correlates of positive immunity ... Full text Link to item Cite

Inhibition of HIV-1 integrase by hydroxocobalamin

Journal Article BLOOD · November 15, 1995 Link to item Cite

Inhibition of productive human immunodeficiency virus-1 infection by cobalamins.

Journal Article Blood · August 15, 1995 Various cobalamins act as important enzyme cofactors and modulate cellular function. We investigated cobalamins for their abilities to modify productive human immunodeficiency virus-1 (HIV-1) infection of hematopoietic cells in vitro. We show that hydroxoc ... Link to item Cite

Extracellular acetylcholine is increased in the nucleus accumbens following the presentation of an aversively conditioned taste stimulus.

Journal Article Brain Res · August 7, 1995 To determine if acetylcholine (ACh) is released in the nucleus accumbens in response to a conditioned stimulus (CS) that reminds the animal of an aversive event, in vivo microdialysis was used to monitor extracellular ACh during conditioned taste aversion. ... Full text Link to item Cite

Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages.

Journal Article Blood · August 1, 1995 Nitric oxide (NO) is produced by numerous different cell types, and it is an important regulator and mediator of many processes including smooth muscle relaxation, neurotransmission, and murine macrophage-mediated cytotoxicity for microbes and tumor cells. ... Link to item Cite

Nitric oxide inhibition of human sperm motility.

Journal Article Fertil Steril · August 1995 OBJECTIVE: To determine the effect of nitric oxide (NO) on sperm motility in vitro. DESIGN: Normal human sperm separated by centrifugation through a discontinuous Percoll gradient and subsequent swim-up were incubated for up to 24 hours with NO donors, wit ... Full text Link to item Cite

Nitric oxide modulation of the growth and differentiation of freshly isolated acute non-lymphocytic leukemia cells.

Journal Article Leuk Res · August 1995 Freshly isolated acute non-lymphocytic leukemia (ANLL) cells were treated with the nitric oxide (NO)-liberating compounds sodium nitroprusside or S-nitrosoacetyl penicillamine and analyzed for viability, growth, and differentiation at 3-5 days. NO decrease ... Full text Link to item Cite

Cellular CD44S as a determinant of human immunodeficiency virus type 1 infection and cellular tropism.

Journal Article J Virol · July 1995 CD4 is the predominant cell membrane protein that binds human immunodeficiency virus type 1 (HIV-1) gp120 and facilitates HIV-1 infection, but other membrane-associated molecules may be involved in determining HIV-1 cellular infection. Our prior work had s ... Full text Link to item Cite

Inhibition of HIV type 1 infection of mononuclear phagocytes by anti-CD44 antibodies.

Journal Article AIDS Res Hum Retroviruses · May 1995 Cellular CD4 is the primary membrane molecule that binds HIV-1 through interaction with viral gp120. Membrane glycolipids and cell adhesion molecules have also been noted to be involved in the interaction of HIV-1 with cells and in syncytium formation in i ... Full text Link to item Cite

Increased levels of laminin in ascitic fluid of patients with ovarian cancer.

Journal Article Cancer Lett · January 6, 1995 Laminin is a component of the extracellular matrix and is associated with tumor cell metastasis. Present studies show that the ovarian cancer cell lines produce significant amounts of laminin (54-140 ng/ml) in culture. Since ovarian cancer is associated wi ... Full text Link to item Cite

Differential effects of interleukin-1 alpha, tumor necrosis factor-alpha, indomethacin, hydrocortisone, and macrophage co-culture on the proliferation of human fibroblasts and peritoneal mesothelial cells.

Journal Article J Soc Gynecol Investig · 1995 OBJECTIVE: We sought to determine whether human fibroblasts and peritoneal mesothelial cells (PMC) are under comparable proliferative controls. METHODS: Human PMC and human fibroblasts were obtained from primary culture of excised explants from infertile w ... Full text Link to item Cite

PIG-A, DAF and proto-oncogene expression in paroxysmal nocturnal haemoglobinuria-associated acute myelogenous leukaemia blasts.

Journal Article Br J Haematol · January 1995 Failed surface expression of the complement decay-accelerating factor (DAF) due to mutation of the PIG-A gene is a hallmark of affected paroxysmal nocturnal haemoglobinuria (PNH) blood elements. Previous findings that acute myelogenous leukaemia (AML) blas ... Full text Link to item Cite

Neopterin production by HIV-1-infected mononuclear phagocytes.

Journal Article J Leukoc Biol · November 1994 Neopterin is a pteridine produced by human mononuclear phagocytes, usually in response to interferon-gamma (IFN-gamma) stimulation. Increasing serum levels of neopterin correlate with clinical progression to AIDS in HIV-infected people, but the factors tha ... Full text Link to item Cite

Human immunodeficiency virus (HIV)-infected human blood monocytes and peritoneal macrophages have reduced anticryptococcal activity whereas HIV-infected alveolar macrophages retain normal activity.

Journal Article J Infect Dis · July 1994 Human immunodeficiency virus type 1 (HIV-1) infection causes immune dysfunction. Mononuclear phagocytes (MNP) are immune effector cells against some intracellular pathogens and reservoirs for HIV-1. This study determined effects of HIV-1 on MNP-mediated an ... Full text Link to item Cite

The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine.

Journal Article J Exp Med · February 1, 1994 MRL-lpr/lpr mice spontaneously develop various manifestations of autoimmunity including an inflammatory arthropathy and immune complex glomerulonephritis. This study examines the role of nitric oxide, a molecule with proinflammatory actions, in the pathoge ... Full text Link to item Cite

Serum and ascitic fluid levels of interleukin-1, interleukin-6, and tumor necrosis factor-alpha in patients with ovarian epithelial cancer.

Journal Article Cancer · October 15, 1993 BACKGROUND: Recent studies have shown that multiple cytokines are secreted by ovarian epithelial cancer cells. Previous studies have shown that the cancer cell lines secrete macrophage colony-stimulating factor (M-CSF), granulocyte-macrophage colony-stimul ... Full text Link to item Cite

Trimethoprim-sulfamethoxazole prophylaxis in granulocytopenic patients with acute leukemia: evaluation of serum antibiotic levels in a randomized, double-blind, placebo-controlled Department of Veterans Affairs Cooperative Study.

Journal Article Clin Infect Dis · September 1993 Despite widespread use of trimethoprim-sulfamethoxazole (TMP-SMZ) for prophylaxis in neutropenic patients, questions remain regarding its efficacy, toxicity, the risk of selection of resistant isolates, and the relation of its activity to selective decolon ... Full text Link to item Cite

Human immunodeficiency virus type 1 infection of human monocytes and macrophages does not alter their ability to generate an oxidative burst.

Journal Article J Infect Dis · August 1993 Human immunodeficiency virus type 1 (HIV-1) infects mononuclear phagocytes, cells that may serve as a reservoir for viral persistence. Infection with HIV-1 leads to progressive compromise of the immune system, resulting in infections with opportunistic pat ... Full text Link to item Cite

Synovial mononuclear phagocytes in rheumatoid arthritis and osteoarthritis: quantitative and functional aspects.

Journal Article Immunol Invest · July 1993 Macrophages are normal constituents of synovial tissue, and in inflammatory synovitis the number of synovial macrophages increases. Synovial macrophages and their secretory products are important in initiating, propagating, and maintaining the synovial inf ... Full text Link to item Cite

Tumor necrosis factor alpha as an autocrine and paracrine growth factor for ovarian cancer: monokine induction of tumor cell proliferation and tumor necrosis factor alpha expression.

Journal Article Cancer Res · April 15, 1993 Ovarian tumor cells produce macrophage colony stimulating factor, a potent chemoattractant for monocytes. Monocytes and macrophages produce tumor necrosis factor alpha (TNF-alpha) and interleukin 1 alpha or interleukin 1 beta (IL-1 beta) that can stimulate ... Link to item Cite

Nitric oxide modulation of human leukemia cell differentiation and gene expression.

Journal Article Blood · October 15, 1992 Nitric oxide (NO) functions as an intercellular messenger molecule in such varied contexts as neurotransmission, immune regulation, and the control of vascular tone. We report that NO, delivered as purified gas or released from the pharmacologic NO donors ... Link to item Cite

Disease severity in rheumatoid arthritis: relationships of plasma tumor necrosis factor-alpha, soluble interleukin 2-receptor, soluble CD4/CD8 ratio, neopterin, and fibrin D-dimer to traditional severity and functional measures.

Journal Article J Clin Immunol · September 1992 Rheumatoid arthritis is a complex inflammatory disease of unknown cause. Although various laboratory and clinical measurements are useful in managing these patients, there is a need for better tests to quantitatively assess disease activity. The purpose of ... Full text Link to item Cite

Nuclear expression of the 50- and 65-kD Rel-related subunits of nuclear factor-kappa B is differentially regulated in human monocytic cells.

Journal Article J Clin Invest · July 1992 The nuclear factor (NF)-kappa B transcription factor system is composed of at least four inducible nucleoprotein adducts termed p50, p55 (NF-kappa B p50), p75 (NF-kappa B p65), and p85 (c-Rel). These proteins are expressed in the nuclei of activated T cell ... Full text Link to item Cite

Inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) messenger RNA (mRNA) expression in HL-60 leukemia cells by pentoxifylline and dexamethasone: dissociation of acivicin-induced TNF-alpha and IL-1 beta mRNA expression from acivicin-induced monocytoid differentiation.

Journal Article Blood · June 15, 1992 We have previously noted that the glutamine antagonist acivicin (alpha S,5S-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid) induces monocytoid differentiation of freshly isolated human myeloid leukemia cells and cells of the myeloid leukemia cell ... Link to item Cite

Flow cytometric analysis of nitric oxide production in human neutrophils using dichlorofluorescein diacetate in the presence of a calmodulin inhibitor.

Journal Article J Leukoc Biol · May 1992 Dichlorofluorescein (DCFH) oxidation assay measures hydrogen peroxide (H2O2), which is a derivative of superoxide anion. We found that a calmodulin antagonist, W-13, which is known to inhibit superoxide anion generation enhanced the capacity of human neutr ... Full text Link to item Cite

Stimulation of ovarian tumor cell proliferation with monocyte products including interleukin-1, interleukin-6, and tumor necrosis factor-alpha.

Journal Article Am J Obstet Gynecol · March 1992 OBJECTIVE: We investigated whether monocyte-derived factors could stimulate the growth of ovarian cancer cells. STUDY DESIGN: Human peripheral blood monocytes or human monocyte-like cell lines THP-1 and U-937 were cultured with or without macrophage colony ... Full text Link to item Cite

The lack of effect of tumor necrosis factor-alpha, interleukin-1-alpha, and interferon-gamma on human sperm motility in vitro.

Journal Article J Androl · 1992 Whether cytokines present in human peritoneal fluid reduce sperm motility, and thus contribute to infertility, is investigated. The human recombinant cytokines, tumor necrosis factor-alpha, interleukin-1-alpha, and interferon-gamma, were incubated with mot ... Link to item Cite

Thrombomodulin expression by human blood monocytes and by human synovial tissue lining macrophages.

Journal Article Blood · December 15, 1991 Thrombomodulin is an essential cofactor for the activation of the anticoagulant protein C by thrombin. We have identified the expression of thrombomodulin messenger RNA (mRNA) and protein in peripheral blood monocytes. While untreated monocytes expressed t ... Link to item Cite

Productive human immunodeficiency virus type 1 (HIV-1) infection of nonproliferating human monocytes.

Journal Article J Exp Med · December 1, 1991 Human immunodeficiency virus type 1 (HIV-1) infection of T lymphocytes requires cellular proliferation and DNA synthesis. Human monocytes were shown to have low DNA synthesis rates, yet the monocytotropic BaL isolate of HIV-1 was able to infect these cells ... Full text Link to item Cite

The stimulus responsible for the peritoneal fluid inflammation observed in infertile women with endometriosis.

Journal Article Fertil Steril · September 1991 OBJECTIVE: We tested the hypothesis that menstrual debris from ectopic endometrium is the stimulus responsible for eliciting the peritoneal fluid (PF) inflammation observed in infertile women with endometriosis. DESIGN, SETTING, PATIENTS: The extent of end ... Full text Link to item Cite

Lack of enhancing effect of human anti-human immunodeficiency virus type 1 (HIV-1) antibody on HIV-1 infection of human blood monocytes and peritoneal macrophages.

Journal Article J Virol · August 1991 The influence of human anti-human immunodeficiency virus type 1 (HIV-1) antibody on HIV-1 infection of freshly isolated normal human peritoneal macrophages and blood monocytes was examined. Each of 14 HIV antibody-positive human serum samples was found to ... Full text Link to item Cite

Extravascular fibrin formation and dissolution in synovial tissue of patients with osteoarthritis and rheumatoid arthritis.

Journal Article Arthritis Rheum · August 1991 Fibrin deposition is a prominent finding in the synovium of patients with rheumatoid arthritis (RA). Macrophages are found in increased numbers in RA synovium, and these cells are known to produce a variety of procoagulant and anticoagulant molecules. Usin ... Full text Link to item Cite

Peritoneal fluid and plasma levels of human macrophage colony-stimulating factor in relation to peritoneal fluid macrophage content.

Journal Article Blood · July 15, 1991 The peritoneal fluid (PF) of women with infertility (especially in the presence of endometriosis) contains increased numbers of leukocytes, 90% to 95% of which are macrophages. The high numbers of peritoneal macrophages presumably result from an influx of ... Link to item Cite

Relationship of acivicin-induced monocytoid differentiation of human myeloid leukemia cells to acivicin-induced modulation of growth factor, cytokine, and protooncogene mRNA expression.

Journal Article Cancer Res · February 15, 1991 We have previously noted that the glutamine antagonist acivicin (alpha S,5S-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid) induces monocytoid differentiation of freshly isolated human myeloid leukemia cells and HL-60 cells. This study was designe ... Link to item Cite

Human alveolar and peritoneal macrophages mediate fungistasis independently of L-arginine oxidation to nitrite or nitrate.

Journal Article Am Rev Respir Dis · December 1990 Human alveolar macrophages (HAM) from 28 normal volunteers were found to inhibit replication of Cryptococcus neoformans. Conditions under which fungistasis occurred were different than those required for mouse peritoneal macrophage-mediated fungistasis. In ... Full text Link to item Cite

CA 125 in peritoneal fluid and serum from patients with benign gynecologic conditions and ovarian cancer.

Journal Article Gynecol Oncol · February 1990 CA 125 was measured in peritoneal fluid from 200 patients with primary ovarian malignancies (35) and benign gynecologic conditions (165). In 86 patients CA 125 was measured both in peritoneal fluid and in serum. Patients with ovarian cancer had markedly gr ... Full text Link to item Cite

Sphingosine inhibits monocyte tissue factor-initiated coagulation by altering factor VII binding.

Journal Article J Biol Chem · November 5, 1989 Tissue factor is a lipoprotein, expressed on the surface of cells, which binds coagulation Factor VII or VIIa, leading to activation of Factors X and IX with subsequent fibrin generation. Cellular tissue factor activity is important in pathophysiologic pro ... Link to item Cite

Chemotactic peptide receptor-cytoskeletal interactions and functional correlations in differentiated HL-60 cells and human polymorphonuclear leukocytes.

Journal Article J Cell Physiol · October 1989 We studied the chemotactic peptide receptor/cytoskeletal interactions in HL-60 cells induced to differentiate with different agents and attempted to correlate these observations with the acquisition of different functional responses. Dibutyryl cyclic AMP-t ... Full text Link to item Cite

Monocytoid differentiation of freshly isolated human myeloid leukemia cells and HL-60 cells induced by the glutamine antagonist acivicin.

Journal Article Blood · October 1989 Previously we showed that starvation of HL-60 promyelocytic leukemia cells for a single essential amino acid induced irreversible differentiation into more mature monocyte-like cells. Although not an essential amino acid, glutamine is important in the grow ... Link to item Cite

GLUCOCORTICOID MODULATION OF CYTOKINE-MEDIATED MACROPHAGE FIBROBLAST INTERACTIONS

Journal Article JOURNAL OF LEUKOCYTE BIOLOGY · October 1, 1989 Link to item Cite

Human mononuclear phagocyte transglutaminase activity cross-links fibrin.

Journal Article Thromb Res · July 1, 1989 The physiologic function of the monocyte transglutaminases is not known. In this study, we detected Factor XIII A-subunit antigen and "tissue" transglutaminase antigen in human monocytes by polyacrylamide gel electrophoresis and immunoblotting techniques. ... Full text Link to item Cite

Essential amino acid deprivation induces monocytic differentiation of the human HL-60 myeloid leukemia cell line.

Journal Article Blood · April 1989 In this study we examine the effects of amino acid deprivation on the growth and differentiation of the human HL-60 myeloid leukemia cell line. The HL-60 cell line was chosen for study because of its ability to differentiate along either a granulocytic or ... Link to item Cite

Alpha 2 macroglobulin-proteinase complexes stimulate prostaglandin E2 synthesis by peritoneal macrophages.

Journal Article Agents Actions · December 1988 alpha 2-Macroglobulin is a proteinase inhibitor which is converted from its native form into an electrophoretically "fast" form by reaction with a proteinase or methylamine. All alpha 2M "fast" forms bind to a specific high-affinity receptor on macrophages ... Full text Link to item Cite

Hematologic and surgical management of the dental patient with plasminogen activator deficiency.

Journal Article Oral Surg Oral Med Oral Pathol · December 1988 Anticoagulation therapy is used to treat patients with a variety of hemostatic disorders in an attempt to prevent thrombus formation. A thorough understanding of the patient's medical history is essential before dental treatment that may require alteration ... Full text Link to item Cite

Clinical trials with human tumor necrosis factor: in vivo and in vitro effects on human mononuclear phagocyte function.

Journal Article Cancer Res · October 1, 1988 The purpose of this investigation was to understand the biological effects of recombinant human tumor necrosis factor used as therapy for cancer. We studied changes in mononuclear phagocyte function following exposure to this cytokine in vitro or in vivo. ... Link to item Cite

SYNOVIAL TISSUE MACROPHAGES IN HUMAN RHEUMATOID-ARTHRITIS AND OSTEO-ARTHRITIS

Journal Article JOURNAL OF LEUKOCYTE BIOLOGY · October 1, 1988 Link to item Cite

SPHINGOSINE INHIBITS TISSUE FACTOR-INDUCED BLOOD-CLOTTING

Journal Article ARTERIOSCLEROSIS · September 1, 1988 Link to item Cite

Reduction of the intraperitoneal inflammation associated with endometriosis by treatment with medroxyprogesterone acetate.

Journal Article Am J Obstet Gynecol · August 1988 An intraperitoneal inflammatory exudate has been repeatedly observed in infertile women without mechanical compromise of the pelvic viscera, particularly with endometriosis. This is manifested by increases in the peritoneal fluid volume, leukocyte number, ... Full text Link to item Cite

Reduced trypsin-binding capacity of alpha 2-macroglobulin in the peritoneal fluid of women with endometriosis: possible relevance to alterations in macrophase function.

Journal Article Fertil Steril · July 1988 Alpha 2-macroglobulin (alpha 2M) is a plasma protein with proteinase inhibitor and immune modulatory capabilities. The amounts of alpha 2M in peritoneal fluid (PF) from women with endometriosis and women with noninflammatory gynecologic conditions were ana ... Full text Link to item Cite

Tumor necrosis factor induces tissue factor-like activity in human leukemia cell line U937 and peripheral blood monocytes.

Journal Article Blood · July 1988 The induction of procoagulant activity (PCA) by human recombinant tumor necrosis factor (rTNF) was studied in human monoblastic leukemia cell line U937 and human peripheral blood monocytes. Using a one-step recalcificating clotting assay, PCA in cell lysat ... Link to item Cite

Human T-cell lymphotropic virus I and adult T-cell leukemia: report of a cluster in North Carolina.

Journal Article Am J Med · July 1988 PURPOSE: Human adult T-cell leukemia-lymphoma is a malignant, proliferative disease of CD4+ lymphocytes associated with infection with human T-cell lymphotropic virus type I (HTLV-I). Following the presentation of a patient who was infected with the virus, ... Full text Link to item Cite

Cooperative effect of tumor necrosis factor and gamma-interferon on chemotactic peptide receptor expression and stimulus-induced actin polymerization in HL-60 cells.

Journal Article Blood · April 1988 We studied the effect of tumor necrosis factor (TNF) and gamma interferon (IFN-gamma), alone and in combination, on the expression of chemotactic peptide receptors, stimulus-induced actin polymerization, hydrogen peroxide production (H2O2), and expression ... Link to item Cite

Erythrocyte anisocytosis. Visual inspection of blood films vs automated analysis of red blood cell distribution width.

Journal Article Arch Intern Med · April 1988 An improved anemia classification may be available by combining measures of red blood cell size variability with mean corpuscular volume. Visual inspection of the peripheral blood film allows semiquantitative description of anisocytosis while quantitative ... Full text Link to item Cite

Transcription interruption may be a common mechanism of c-myc regulation during HL-60 differentiation.

Journal Article Biochem Biophys Res Commun · February 29, 1988 Human promyelocytic leukemia cells (HL-60) differentiate along a monocytoid pathway in response to recombinant human tumor necrosis factor or recombinant human interferon gamma. Together, these agents act synergistically to induce phenotypic differentiatio ... Full text Link to item Cite

Sperm-macrophage interaction in the mouse: a quantitative assay in vitro using 111indium oxine-labeled sperm.

Journal Article Biol Reprod · December 1987 The role of reproductive tract macrophages in contraception and reproductive failure has become widely recognized. However, in vitro analysis of sperm phagocytosis by macrophages has relied upon a semi-quantitative method of sperm counting that is of limit ... Full text Link to item Cite

Tumor necrosis factor-alpha induces increased hydrogen peroxide production and Fc receptor expression, but not increased Ia antigen expression by peritoneal macrophages.

Journal Article J Leukoc Biol · December 1987 It has recently been shown that tumor necrosis factor (TNF) induces increased Ia antigen expression on a malignant murine macrophage cell line, and that TNF is synergistic with gamma interferon (IFN) in inducing Ia expression. This finding raises the possi ... Full text Link to item Cite

The nature of the intraperitoneal exudate associated with infertility: peritoneal fluid and serum lysozyme activity.

Journal Article Fertil Steril · November 1987 An intraperitoneal inflammatory process has been associated with infertility in women without anatomic distortion of the pelvic viscera, particularly with endometriosis. This phenomenon was investigated by measuring peritoneal fluid (PF) and serum levels o ... Link to item Cite

1 alpha,25 Dihydroxyvitamin D3 and mononuclear phagocytes: enhancement of mouse macrophage and human monocyte hydrogen peroxide production without alteration of tumor cytolysis.

Journal Article J Leukoc Biol · November 1987 1 alpha,25 dihydroxyvitamin D3 (1,25 D3) is known to interact with hematopoietic cells. The purpose of this study was to determine the effect of 1,25 D3 on hydrogen peroxide (H2O2) production and tumor cell killing by mouse peritoneal macrophages and human ... Full text Link to item Cite

Receptor-mediated monocytoid differentiation of human promyelocytic cells by tumor necrosis factor: synergistic actions with interferon-gamma and 1,25-dihydroxyvitamin D3.

Journal Article Blood · October 1987 Human myeloid leukemia cells respond to various signals by differentiating to more mature cells. This study was designed to evaluate the effects of a mononuclear phagocyte-derived factor, tumor necrosis factor/cachectin (TNF), on the proliferation and diff ... Link to item Cite

Modulation of mouse peritoneal macrophage Ia and human peritoneal macrophage HLA-DR expression by alpha 2-macroglobulin "fast" forms.

Journal Article J Immunol · September 15, 1987 alpha 2-Macroglobulin (alpha 2M) is converted from its native form into electrophoretically "fast" forms by reaction with proteinases or with methylamine. The "fast" forms both bind to specific receptors on macrophages (MP). We have previously shown that a ... Link to item Cite

Metastatic hemangiopericytoma with prolonged survival.

Journal Article Cancer · August 15, 1987 A case of a hemangiopericytoma tumor metastatic to the lung from a central nervous system primary tumor in the posterior fossa is reported. The tumor was not responsive to treatment with cyclophosphamide, Adriamycin (doxorubicin), vincristine, DTIC (CYVADI ... Full text Link to item Cite

Functional alterations of macrophages in autoimmune MRL-lpr/lpr mice.

Journal Article J Immunol · March 15, 1987 To assess the role of macrophages (MAC) in the pathogenesis of systemic lupus erythematosus, we investigated functional aspects of peritoneal MAC obtained from autoimmune MRL/MpJ-lpr/lpr (MRL-lpr) mice. MRL-lpr and control C3H/HeN MAC were obtained from un ... Link to item Cite

TUMOR-NECROSIS-FACTOR INDUCES TISSUE FACTOR ACTIVITY IN HUMAN-LEUKEMIA CELL-LINE U937

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · March 1, 1987 Link to item Cite

MODULATION OF PERITONEAL MACROPHAGE (MP) MEMBRANE-ANTIGENS BY ALPHA2-MACROGLOBULIN TRYPSIN (A2M-T) COMPLEXES

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · March 1, 1987 Link to item Cite

Antibodies to granulocyte precursors in selective myeloid hypoplasia and other suspected autoimmune neutropenias: use of HL-60 cells as targets.

Journal Article Blood · February 1987 Patients with syndromes of autoantibody-mediated hematocytopenias may manifest signs of increased cell destruction and/or decreased cell production, depending on the maturity of the target cell and the effects of antibody binding. The purpose of this study ... Link to item Cite

Acute myeloblastic leukemia in paroxysmal nocturnal hemoglobinuria. Evidence of evolution from the abnormal paroxysmal nocturnal hemoglobinuria clone.

Journal Article J Clin Invest · January 1987 Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hematopoietic stem cell disorder in which the blood cells demonstrate aberrant interactions with serum complement. In part, this is due to the absence of the complement regulatory protein, decay acce ... Full text Link to item Cite

In vitro function of indium-111 oxine-labeled human monocytes.

Journal Article J Immunol Methods · December 4, 1986 Mononuclear phagocytes (monocytes and macrophages) are widely distributed throughout the body. Indium-111 (111In) oxine has been a useful radioactive label in studies of in vivo cellular kinetics and distribution. In preparation for in vivo monocyte invest ... Full text Link to item Cite

Cooperative effects of gamma interferon and 1-alpha,25-dihydroxyvitamin D3 in inducing differentiation of human promyelocytic leukemia (HL-60) cells.

Journal Article Exp Hematol · February 1986 Various agents induce differentiation of human leukemia cells in vitro. Most of these agents cause myeloid differentiation, but phorbol diesters, 1-alpha,25-dihydroxyvitamin D3 (1,25[OH2]D3), and certain lymphokines cause differentiation to monocyte-like c ... Link to item Cite

Phenotypic characterization of gamma interferon-induced human monocyte polykaryons.

Journal Article Blood · December 1985 Multinucleated giant cells of mononuclear phagocyte origin (monocyte or macrophage polykaryons [MPs] ) are seen in numerous different normal and pathologic states. We have previously shown that gamma interferon (IFN-gamma) induces fusion of uninuclear mono ... Link to item Cite

Peritoneal macrophages and infertility: the association between cell number and pelvic pathology.

Journal Article Fertil Steril · December 1985 Increased numbers of peritoneal macrophages have been repeatedly associated with infertility. Because the factors contributing to this intraperitoneal exudate are unknown, this study was carried out to determine which anatomic or endocrinologic abnormaliti ... Full text Link to item Cite

Treatment of red cell aplasia with antithymocyte globulin: repeated inductions of complete remissions in two patients.

Journal Article Am J Hematol · October 1985 Two patients with red cell aplasia unresponsive to prednisone and cyclophosphamide were treated with antithymocyte globulin (ATG). Both patients developed reticulocytosis within 2-4 days after ATG treatment and had complete remissions. Within 4-6 months, t ... Full text Link to item Cite

Leukemic ascites complicating acute myelomonoblastic leukemia.

Journal Article Arch Pathol Lab Med · April 1985 We describe a patient with acute myelomonoblastic leukemia, jaundice, and ascites. The ascitic fluid contained leukemic cells comparable with those of the blood and bone marrow. Treatment with cytarabine (cytosine arabinoside) caused a decrease in the peri ... Link to item Cite

Macrophages and infertility: enhancement of human macrophage-mediated sperm killing by antisperm antibodies.

Journal Article Fertil Steril · February 1985 The mechanism by which antisperm antibodies inhibit fertility is not completely understood. Macrophages may play a role in mediating infertility by interacting with sperm and destroying gametes. Experiments were conducted evaluating the effect of antisperm ... Link to item Cite

Microassay for the photometric quantitation of cell-associated plasminogen activator using a chromogenic tripeptide substrate.

Journal Article J Immunol Methods · December 31, 1984 Plasminogen activator (PA), a neutral protease whose primary function is to convert plasminogen to plasmin, is produced by various cells including macrophages, monocytes, endothelial cells, and tumor cells. This study reports the use of the chromogenic tri ... Full text Link to item Cite

Comparison of in vitro and in vivo differentiation of myeloblastic leukemia of the RFM/Un mouse.

Journal Article Cancer research · December 1984 Various human and mouse myeloid leukemia cell lines can differentiate to mature myeloid or monocytoid cells in response to different agents. The myeloblastic leukemia of the RFM/Un mouse (the RF.AML line) was studied here to determine its ability to differ ... Cite

Peritoneal fluid prolactin in infertile women with endometriosis: lack of evidence of secretory activity by endometrial implants.

Journal Article Fertil Steril · December 1984 To evaluate the functional status of endometriotic implants, a luteal secretory product of endometrium, PRL, was measured in the PF of 27 infertile women with endometriosis, 13 infertile women without endometriosis, and 11 fertile women undergoing elective ... Link to item Cite

Comparison of in Vitro and in Vivo Differentiation of Myeloblastic Leukemia of the RFM/Un Mouse

Journal Article Cancer Research · December 1, 1984 Various human and mouse myeloid leukemia cell lines can differentiate to mature myeloid or monocytoid cells in response to different agents. The myeloblastic leukemia of the RFM/Un mouse (the RF.AML line) was studied here to determine its ability to differ ... Cite

Comparison of in vitro and in vivo differentiation of myeloblastic leukemia of the RFM/Un mouse.

Journal Article Cancer Res · December 1984 Various human and mouse myeloid leukemia cell lines can differentiate to mature myeloid or monocytoid cells in response to different agents. The myeloblastic leukemia of the RFM/Un mouse (the RF.AML line) was studied here to determine its ability to differ ... Link to item Cite

Recombinant human gamma-interferon induces human monocyte polykaryon formation.

Journal Article Proc Natl Acad Sci U S A · July 1984 Monocyte or macrophage polykaryons (MP) are seen in different tissues in various inflammatory states and in normal bone (osteoclasts). The factors controlling the formation and the function of MP are not completely understood. This study was designed to ev ... Full text Link to item Cite

Diverse humoral and cell-mediated effects of antisperm antibodies on reproduction.

Journal Article Fertil Steril · June 1984 No single test to detect the presence of antisperm antibodies has correlated precisely with subsequent fertility. The purpose of this study was to determine whether heterogeneous effects of antibodies could potentially explain this observation. The effects ... Link to item Cite

Human leukemia cell lines with comparable receptor binding characteristics but different phenotypic responses to phorbol diesters.

Journal Article Cancer Res · March 1984 Phorbol diester (PDE) tumor promoters have differing effects on normal and neoplastic hematopoietic cells in vitro. The effects of PDEs on cells are apparently mediated by specific cellular receptors for these ligands. The purpose of this study was to dete ... Link to item Cite

Specific receptors for phorbol diesters on freshly isolated human myeloid and lymphoid leukemia cells: comparable binding characteristics despite different cellular responses.

Journal Article Blood · February 1984 Freshly isolated human leukemia cells have been shown in the past to display varying in vitro responses to phorbol diesters, depending on their cell type. Specific receptors for the phorbol diesters have been demonstrated on numerous different cells. This ... Link to item Cite

Extramedullary recurrence of acute lymphoblastic leukemia 15 years after initial diagnosis.

Journal Article Med Pediatr Oncol · 1984 We describe a 19-year-old man with recurrence of a lymphoid malignancy involving the ethmoid sinus 15 years following diagnosis and 10 years after discontinuation of therapy for childhood acute lymphoblastic leukemia (ALL). The cytologic appearance and imm ... Full text Link to item Cite

RECOMBINANT GAMMA INTERFERON (IFN-GAMMA) INDUCES HUMAN MONOCYTE ACTIVATION AND POLYKARYON FORMATION

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · January 1, 1984 Link to item Cite

Enhancement of macrophage-mediated tumor cell killing by bacterial outer membrane proteins (porins).

Journal Article Infect Immun · October 1983 Various microbial products are known to influence the function of mouse peritoneal macrophages. Lipopolysaccharide (LPS) and certain lipid A-associated proteins are known to enhance the tumoricidal effects of macrophages. The purpose of this study was to d ... Full text Link to item Cite

Phorbol diester-induced H2O2 production by peritoneal macrophages. Different H2O2 production by macrophages from normal and BCG-infected mice despite comparable phorbol diester receptors.

Journal Article Cell Immunol · September 1983 Mouse peritoneal macrophages respond to environmental stimuli in different ways depending on their state of differentiation. Macrophages from mice with bacillus Calmette--Guerin (BCG) infection produced large amounts of H2O2 in response to phorbol diesters ... Full text Link to item Cite

Spontaneous tumor cell killing by human blood monocytes and human peritoneal macrophages: lack of alteration by endotoxin or quenchers of reactive oxygen species.

Journal Article J Natl Cancer Inst · June 1983 Human mononuclear phagocytes (monocytes and macrophages) act as effectors in the destruction of tumor cells. Peritoneal macrophages from normal or infertile women killed a variety of tumor cells in vitro more efficiently than did blood monocytes from the s ... Link to item Cite

Macrophages and infertility: oviductal macrophages as potential mediators of infertility.

Journal Article Fertil Steril · March 1983 Human peritoneal macrophages have previously been shown to phagocytize normal sperm. We had hypothesized that if macrophages were present in the distal oviducts, they could interfere with fertilization by phagocytizing sperm in vivo. The present study was ... Full text Link to item Cite

Macrophage polykaryon formation in vitro by peritoneal cells from mice given injections of sodium periodate.

Journal Article Am J Pathol · February 1983 Peritoneal macrophages from mice that have received two separate intraperitoneal injections of the sterile, soluble oxidant NaIO4 form macrophage polykaryons (MPs) in vitro, but peritoneal macrophage from untreated, peptone-treated, or mice infected with b ... Link to item Cite

Sperm phagocytosis by human peritoneal macrophages: a possible cause of infertility in endometriosis.

Journal Article Am J Obstet Gynecol · November 1, 1982 The mechanism of infertility in women with endometriosis is unknown, but it is independent of mechanical factors that affect fallopian tube function. Increased numbers of peritoneal macrophages are present in women with endometriosis and have access to the ... Full text Link to item Cite

Receptor-mediated modulation of human monocyte, neutrophil, lymphocyte, and platelet function by phorbol diesters.

Journal Article J Clin Invest · October 1982 The tumor promoting phorbol diesters elicit a variety of responses from normal and leukemic blood cells in vitro by apparently interacting with cellular receptors. The biologically active ligand [20-(3)H] phorbol 12,13-dibutyrate ([(3)H]PDBu) bound specifi ... Full text Link to item Cite

Specific phorbol diester receptors on normal and leukemic blood-cells: Relationships of binding to cellular responses

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1982 Cite

HUMAN OVIDUCTAL (OM) AND PERITONEAL-MACROPHAGES (PM) AS CELLULAR MEDIATORS OF INFERTILITY

Journal Article JOURNAL OF THE RETICULOENDOTHELIAL SOCIETY · January 1, 1982 Link to item Cite

RECEPTOR-BINDING AND SIGNAL TRANSMISSION IN CGD NEUTROPHILS

Journal Article CLINICAL RESEARCH · January 1, 1982 Link to item Cite

SPECIFIC PHORBOL DIESTER RECEPTORS ON NORMAL AND LEUKEMIC BLOOD-CELLS - RELATIONSHIPS OF BINDING TO CELLULAR-RESPONSES

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · January 1, 1982 Link to item Cite

Monocyte chemotactic peptide receptor. Functional characteristics and ligand-induced regulation.

Journal Article J Clin Invest · September 1981 Monocytes, macrophages, and neutrophils will demonstrate several important cellular functions in response to synthetic formylated oligopeptides. N-formyl-norleucyl-leucyl-phenylalanyl-norleucyl-tyrosyl-lysine (fNLPNTL) was a potent chemoattractant for huma ... Full text Link to item Cite

Tumor cell killing by phorbol ester--differentiated human leukemia cells.

Journal Article Science · August 7, 1981 The tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate causes differentiation of cells of the human leukemia cell line HL60 to nondividing macrophage-like cells. These differentiated cells are cytotoxic for tumor cells (including parent, untreated HL60 c ... Full text Link to item Cite

In vivo modulation of macrophage tumoricidal activity: enhanced tumor cell killing by peritoneal macrophages from mice given injections of sodium periodate.

Journal Article J Natl Cancer Inst · March 1981 Sodium periodate (NaIO4) administered ip to mice was nontoxic and enhanced the in vitro tumoricidal activity of their peritoneal macrophages. The injection ip of 1 ml of 5 mM NaIO4 caused an influx of polymorphonuclear leukocytes (PMN) at 5-24 hours follow ... Link to item Cite

Analysis of a large pedigree with elliptocytosis, multiple lipomatosis, and biological false-positive serological test for syphilis.

Journal Article Am J Med Genet · 1980 Elliptocytosis, multiple lipomatosis, and biological false-postive serological test for syphilis (BFPSTS) were found in a single individual. One hundred eighty relatives were tested for the three diseases: 74 were typed for seven blood group antigens, and ... Full text Link to item Cite

In vitro modulation of macrophage tumoricidal activity - Enhanced tumor cell killing by sodium periodate-treated peritoneal macrophages or sodium periodate-treated cloned macrophages

Journal Article Cancer Immunology Immunotherapy · January 1, 1980 NaIO4 treatment of mouse adherent peritoneal cells or lymphocyte-free cloned macrophages enhances their cytotoxic and tumoricidal activity. 5×10-3 M NaIO4 treatment of nontumoricidal BCG-activated macrophages renders them c ... Full text Cite

Enhanced macrophage tumoricidal activity and tumor suppression or regression caused by heat-killed Candida albicans.

Journal Article J Natl Cancer Inst · November 1979 The growth of line-10 hepatoma in male Sewall Wright strain 2 guinea pigs was totally suppressed when tumor cells were mixed with heat-killed Candida albicans. In a significant number of animals, injection of C. albicans into established tumors 10-12 mm in ... Link to item Cite

Blast cell leukemia with IgM monoclonal gammopathy and intracytoplasmic vacuoles and Auer-body-like inclusions.

Journal Article Am J Clin Pathol · February 1979 A patient with acute leukemia and an IgM, kappa (IgMkappa) monoclonal gammopathy, Bence-Jones proteinuria, and blasts containing intracytoplasmic vacuoles with peroxidase-positive inclusions is discussed. Special stains, immunofluorescence, and electron mi ... Full text Link to item Cite

In vivo administered NaIO4 causes macrophage polykaryon formation in vitro and enhances macrophage tumoricidal activity

Journal Article RES Journal of the Reticuloendothelial Society · January 1, 1978 Cite

Macrophage tumor killing: influence of the local environment.

Journal Article Science · July 15, 1977 Tumor killing by activated macrophages is not a highly determined biologic event, but a relative capability influenced by the local environment. An intrinsic macrophage cytotoxic effector system is modulated by serum and other environmental factors that ca ... Full text Link to item Cite

The role of endotoxin in activated macrophage tumor cell killing

Journal Article RES Journal of the Reticuloendothelial Society · January 1, 1977 Cite