Scholars@Duke
Stanley J. Robboy

Stanley J. Robboy

Professor Emeritus of Pathology
Pathology
stanley.robboy@duke.edu
Duke Box 3712, Durham, NC 27710
M227 Davison Bldg, Durham, NC 27710

Selected Publications

An Update on Prenatal Diethylstilbestrol Exposure and High-Grade Squamous Intraepithelial Lesions of the Lower Genital Tract.

Journal Article Obstet Gynecol · April 1, 2024 Women with prenatal diethylstilbestrol exposure are excluded from less frequent cervical cancer screening because of their increased neoplasia risk. We report the results of a prospective follow-up study of prenatal diethylstilbestrol exposure and lower ge ... Full text Link to item Cite

Strong Job Market for Pathologists: Results From the 2021 College of American Pathologists Practice Leader Survey.

Journal Article Arch Pathol Lab Med · April 1, 2023 CONTEXT.—: There has long been debate about whether and when there may be a shortage of pathologists in the United States. One way to assess this is to survey the hiring experiences of pathology practices. A 2018 survey revealed a strong demand for patholo ... Full text Link to item Cite

Features of burnout amongst pathologists: A reassessment.

Journal Article Acad Pathol · 2022 There has been little rigorous assessment of burnout among pathologists and pathology trainees. Given this relative dearth of relevant literature on pathologist burnout, this report aims to raise awareness of the issue among those working in and around thi ... Full text Link to item Cite

Evaluation of Host Immune Cellular and Extracellular Matrix Responses to Prolapse Mesh With and Without Tension in a Rat Model.

Journal Article Female Pelvic Med Reconstr Surg · February 1, 2021 OBJECTIVES: We sought to determine whether vaginal host immune cellular and extracellular matrix responses are altered in a rat sacrocolpopexy model when lightweight polypropylene mesh is attached on tension versus without tension. METHODS: We performed hy ... Full text Link to item Cite

Polycarbonate Urethane Mesh: A New Material for Pelvic Reconstruction.

Journal Article Female Pelvic Med Reconstr Surg · February 1, 2021 OBJECTIVE: Polycarbonate urethane (PCU) is a new biomaterial, and its mechanical properties can be tailored to match that of vaginal tissue. We aimed to determine whether vaginal host immune and extracellular matrix responses differ after PCU versus lightw ... Full text Link to item Cite

Evidence-Based Alignment of Pathology Residency With Practice II: Findings and Implications.

Journal Article Acad Pathol · 2021 This article presents findings from a 4-year series of surveys of new-in-practice pathologists, and a survey of physician employers of new pathologists, assessing how pathology graduate medical education prepares its graduates for practice. Using the metho ... Full text Link to item Cite

Reevaluation of the US Pathologist Workforce Size.

Journal Article JAMA Netw Open · July 1, 2020 IMPORTANCE: There is currently no national organization that publishes its data that serves as the authoritative source of the pathologist workforce in the US. Accurate physician numbers are needed to plan for future health care service requirements. OBJEC ... Full text Link to item Cite

The State of the Job Market for Pathologists: Evidence From the College of American Pathologists Practice Leader Survey.

Journal Article Arch Pathol Lab Med · April 2020 CONTEXT.—: Disagreement exists within the pathology community about the status of the job market for pathologists. Although many agree that jobs in pathology were harder to come by earlier this decade, recent evidence suggests improvement is occurring. OBJ ... Full text Link to item Cite

Whole-Genome and Segmental Homozygosity Confirm Errors in Meiosis as Etiology of Struma Ovarii.

Journal Article Cytogenet Genome Res · 2020 Strumae ovarii are neoplasms composed of normal-appearing thyroid tissue that occur within the ovary and rarely spread to extraovarian sites. A unique case of struma ovarii with widespread dissemination detected 48 years after removal of a pelvic dermoid p ... Full text Link to item Cite

Social Media Engagement at Academic Conferences: Report of the Association of Pathology Chairs 2018 and 2019 Annual Meeting Social Media Committee.

Journal Article Acad Pathol · 2020 The use of social media at academic conferences is expanding, and platforms such as Twitter are used to share meeting content with the world. Pathology conferences are no exception, and recently, pathology organizations have promoted social media as a way ... Full text Link to item Cite

Prenatal diethylstilbestrol exposure and cancer risk in women.

Journal Article Environ Mol Mutagen · June 2019 In the Diethylstilbestrol [DES] Combined Cohort Follow-up, the age- and calendar-year specific standardized incidence ratio [SIR] for clear cell adenocarcinoma [CCA] was 27.6 (95% confidence interval [CI] 7.51-70.6) for the exposed women. The SIR for breas ... Full text Link to item Cite

In Reply.

Journal Article Arch Pathol Lab Med · March 2019 Full text Link to item Cite

Reproductive tract biology: Of mice and men.

Journal Article Differentiation · 2019 The study of male and female reproductive tract development requires expertise in two separate disciplines, developmental biology and endocrinology. For ease of experimentation and economy, the mouse has been used extensively as a model for human developme ... Full text Link to item Cite

A Review and Update on Papillary Immature Metaplasia of the Uterine Cervix: A Distinct Subset of Low-Grade Squamous Intraepithelial Lesion, Proposing a Possible Cell of Origin.

Journal Article Arch Pathol Lab Med · August 2018 CONTEXT: - Papillary immature metaplasia (PIM) is a known papillary cervical lesion associated with low-risk human papillomavirus (LR-HPV). OBJECTIVE: - To evaluate additional clinicopathologic features and the HPV genotypes of PIM and discuss the presumpt ... Full text Link to item Cite

The Life Cycle of the Uterine Fibroid Myocyte.

Journal Article Curr Obstet Gynecol Rep · June 2018 PURPOSE OF REVIEW: Uterine fibroids are common benign tumors of women in the USA and worldwide, yet the biological nature and pathogenesis of these tumors remain largely unknown. This review presents our view of the stages in the life cycle of a subset of ... Full text Link to item Cite

Tissue interactions and estrogenic response during human female fetal reproductive tract development.

Journal Article Differentiation · 2018 The role of tissue interactions was explored to determine whether epithelial differentiation within the developing human reproductive tract is induced and specified by mesenchyme in tissue recombinants composed of mouse vaginal mesenchyme + human uterine t ... Full text Link to item Cite

Evidence-Based Alignment of Pathology Residency With Practice: Methodology and General Consideration of Results.

Journal Article Acad Pathol · 2018 Few medical specialties engage in ongoing, organized data collection to assess how graduate medical education in their disciplines align with practice. Pathology educators, the American Board of Pathology, and major pathology organizations undertook an evi ... Full text Link to item Cite

Development of the human female reproductive tract.

Journal Article Differentiation · 2018 Development of the human female reproductive tract is reviewed from the ambisexual stage to advanced development of the uterine tube, uterine corpus, uterine cervix and vagina at 22 weeks. Historically this topic has been under-represented in the literatur ... Full text Link to item Cite

Structured Annual Faculty Review Program Accelerates Professional Development and Promotion: Long-Term Experience of the Duke University Medical Center's Pathology Department.

Journal Article Acad Pathol · 2017 This retrospective observational study on faculty development analyzes the Duke University Pathology Department's 18-year experience with a structured mentoring program involving 51 junior faculty members. The majority had MD degrees only (55%). The percen ... Full text Link to item Cite

New insights into human female reproductive tract development.

Journal Article Differentiation · 2017 We present a detailed review of the embryonic and fetal development of the human female reproductive tract utilizing specimens from the 5th through the 22nd gestational week. Hematoxylin and eosin (H&E) as well as immunohistochemical stains were used to st ... Full text Link to item Cite

Molecular mechanisms of development of the human fetal female reproductive tract.

Journal Article Differentiation · 2017 Human female reproductive tract development rests mostly upon hematoxilyn and eosin stained sections despite recent advances on molecular mechanisms in mouse studies. We report application of immunohistochemical methods to explore the ontogeny of epithelia ... Full text Link to item Cite

Response of xenografts of developing human female reproductive tracts to the synthetic estrogen, diethylstilbestrol.

Journal Article Differentiation · 2017 Human female fetal reproductive tracts 9.5-22 weeks of gestation were grown for 1 month in ovariectomized athymic adult female mouse hosts that were either untreated or treated continuously with diethylstilbestrol (DES) via subcutaneous pellet. Normal morp ... Full text Link to item Cite

Prenatal diethylstilbestrol exposure and high-grade squamous cell neoplasia of the lower genital tract.

Journal Article Am J Obstet Gynecol · September 2016 BACKGROUND: Prenatal diethylstilbestrol (DES) exposure is associated with an excess risk of clear-cell adenocarcinoma of the vagina and cervix, and of high-grade squamous neoplasia. OBJECTIVE: We explored whether neoplasia risk remains elevated among DES-e ... Full text Link to item Cite

Thyroid-Type Carcinomas of Ovarian Origin (Malignant Struma Ovarii)

Journal Article AJSP: Reviews and Reports · September 1, 2016 Struma ovarii is a monodermal variant of mature teratoma in which thyroid tissue predominates. Rarely, struma ovarii undergoes malignant transformation. Malignant struma ovarii (MSO) includes tumor types seen in the eutopic thyroid, such as papillary thyro ... Full text Cite

The Pathologist Workforce in the United States: II. An Interactive Modeling Tool for Analyzing Future Qualitative and Quantitative Staffing Demands for Services.

Journal Article Arch Pathol Lab Med · November 2015 CONTEXT: Pathologists are physicians who make diagnoses based on interpretation of tissue and cellular specimens (surgical/cytopathology, molecular/genomic pathology, autopsy), provide medical leadership and consultation for laboratory medicine, and are in ... Full text Link to item Cite

Factors associated with a lack of pap smear utilization in women exposed in utero to diethylstilbestrol.

Journal Article J Womens Health (Larchmt) · April 2015 BACKGROUND: Women in the 1940s-1960s were prescribed diethylstilbestrol (DES), a nonsteroidal estrogen, to prevent miscarriages, but the practice was terminated after it was discovered that the daughters so exposed in utero were at increased risk for devel ... Full text Link to item Cite

Defective pericyte recruitment of villous stromal vessels as the possible etiologic cause of hydropic change in complete hydatidiform mole.

Journal Article PLoS One · 2015 The pathogenetic mechanism underlying the hydropic change in complete hydatidiform moles (CHMs) is poorly understood. A growing body of data suggests that pericytes play a role in vascular maturation. Since maturation of villous stromal vessels in CHMs is ... Full text Link to item Cite

An Innovative Interactive Modeling Tool to Analyze Scenario-Based Physician Workforce Supply and Demand.

Journal Article Acad Pathol · 2015 Effective physician workforce management requires that the various organizations comprising the House of Medicine be able to assess their current and future workforce supply. This information has direct relevance to funding of graduate medical education. W ... Full text Link to item Cite

Pathologist workforce in the United States: I. Development of a predictive model to examine factors influencing supply.

Journal Article Arch Pathol Lab Med · December 2013 CONTEXT: Results of prior pathology workforce surveys have varied between a state of equilibrium and predictions of shortage. OBJECTIVE: To assess the current and future supply of pathologists, and apply a dynamic modeling tool for assessing the effects of ... Full text Link to item Cite

Prognostic value of the diagnostic criteria distinguishing endometrial stromal sarcoma, low grade from undifferentiated endometrial sarcoma, 2 entities within the invasive endometrial stromal neoplasia family.

Journal Article Int J Gynecol Pathol · May 2013 The World Health Organization (WHO 2003) recognizes 3 endometrial stromal neoplasms: noninvasive endometrial stromal nodule and the 2 invasive neoplasms, endometrial stromal sarcoma (ESS), low grade and undifferentiated endometrial sarcoma (UES). It is imp ... Full text Open Access Link to item Cite

Vulvar vascular tumors: a clinicopathologic study of 85 patients.

Journal Article Am J Dermatopathol · February 2013 The subepidermal hormonally sensitive tissue of the vulva is anatomically unique and may give rise to a wide variety of vascular tumors. As a consequence, classifying vulvar vascular lesions has been challenging due both to the wide variety of lesions that ... Full text Link to item Cite

The natural history of uterine leiomyomas: light and electron microscopic studies of fibroid phases, interstitial ischemia, inanosis, and reclamation.

Journal Article Obstet Gynecol Int · 2013 We propose, and offer evidence to support, the concept that many uterine leiomyomas pursue a self-limited life cycle. This cycle can be arbitrarily divided on the basis of morphologic assessment of the collagen content into 4 phases: (1) proliferation, (2) ... Full text Link to item Cite

Can proliferation biomarkers reliably predict recurrence in World Health Organization 2003 defined endometrial stromal sarcoma, low grade?

Journal Article PLoS One · 2013 An estimated 1500-3000 invasive Endometrial Stromal Sarcomas (ESS) cases annually occur worldwide. Before 2003, ESS was divided as low and high grade ESS based on mitotic activity. In 2003 the WHO changed the names, excluded mitoses and made nuclear atypia ... Full text Link to item Cite

The natural history of uterine leiomyomas: morphometric concordance with concepts of interstitial ischemia and inanosis.

Journal Article Obstet Gynecol Int · 2013 Based upon our morphologic observations, we hypothesize and also provide morphometric evidence for the occurrence of progressive developmental changes in many uterine fibroids, which can be arbitrarily divided into 4 phases. These developmental phases are ... Full text Link to item Cite

Vagina

Chapter · July 16, 2012 Cite

Malignant struma ovarii: a blinded study of 86 cases assessing which histologic features correlate with aggressive clinical behavior.

Journal Article Arch Pathol Lab Med · February 2012 CONTEXT: Struma ovarii exhibiting malignant histology are uncommon, and an aggressive clinical course in the form of initial extraovarian spread or recurrence is even more exceptional for these tumors. OBJECTIVE: To determine whether specific histologic fe ... Full text Link to item Cite

Mammography screening behaviors of women exposed prenatally to diethylstilbestrol.

Journal Article J Womens Health (Larchmt) · February 2012 BACKGROUND: In utero diethylstilbestrol (DES) exposure is a risk factor for rare development of vaginal and cervical cancer and may potentially be a risk factor for breast cancer. Mammography use in this population is relatively unknown; therefore, this st ... Full text Link to item Cite

Adverse Health Outcomes in Women Exposed In Utero to Diethylstilbestrol

Journal Article Obstetrical & Gynecological Survey · February 2012 Full text Cite

Quality and the college of american pathologists.

Journal Article Arch Pathol Lab Med · November 2011 The College of American Pathologists (CAP) is dedicated to pathology and laboratory medicine quality. The CAP's Laboratory Accreditation Program, Proficiency Testing Program, Q-Probes and Q-Tracks, site-specific cancer checklists, webinars, annual meetings ... Full text Link to item Cite

Adverse health outcomes in women exposed in utero to diethylstilbestrol.

Journal Article N Engl J Med · October 6, 2011 BACKGROUND: Before 1971, several million women were exposed in utero to diethylstilbestrol (DES) given to their mothers to prevent pregnancy complications. Several adverse outcomes have been linked to such exposure, but their cumulative effects are not wel ... Full text Link to item Cite

Vulvar manifestations of Crohn's disease.

Journal Article Am J Dermatopathol · August 2011 Crohn's disease is an inflammatory bowel disorder with several well-known extraintestinal manifestations, such as erythema nodosum, uveitis, and arthritis. Less commonly observed are vulvar manifestations, which have primarily been discussed in case report ... Full text Link to item Cite

Preterm birth, fetal growth, and age at menarche among women exposed prenatally to diethylstilbestrol (DES).

Journal Article Reprod Toxicol · February 2011 Diethylstilbestrol (DES), a synthetic estrogen used in pregnancy during the 1950s and 1960s, provides a model for potential health effects of endocrine disrupting compounds in the environment. We evaluated prenatal exposure to DES, based on medical record ... Full text Link to item Cite

Endocervical-like (Müllerian) mucinous borderline tumours of the ovary are frequently associated with the KRAS mutation.

Journal Article Histopathology · October 2010 AIMS:   Clinicopathological aspects of the endocervical-like mucinous borderline tumour of the ovary (EMBT), including higher frequencies of bilaterality, endometriosis and hormone receptor reactivity, and often admixtures of various Müllerian-type epithel ... Full text Link to item Cite

Autoimmune disease incidence among women prenatally exposed to diethylstilbestrol.

Journal Article J Rheumatol · October 2010 OBJECTIVE: Animal studies have suggested that prenatal diethylstilbestrol (DES) exposure may alter immune system development and function including antigen self-recognition. A cohort study was conducted to investigate whether prenatal DES exposure might in ... Full text Link to item Cite

Acquired vulvar lymphangioma circumscriptum: a comparison of 12 cases with Crohn's associated lesions or radiation therapy induced tumors.

Journal Article J Cutan Pathol · September 2010 BACKGROUND: Lymphangioma circumscriptum (LC) is a benign lesion of lymphatic origin. Vulvar involvement occurs in various clinical settings. METHODS: We present 12 cases, and compare lesions in patients with Crohn's disease and those associated with pelvic ... Full text Link to item Cite

Pathogenesis of endometriosis.

Journal Article Reprod Biomed Online · July 2010 Many theories have been proffered to explain the histogenesis of endometriosis (Robboy et al., 2009). Generally, they divide into those that favour transplantation of endometrial fragments to ectopic sites, metaplasia of the multipotential celomic peritone ... Full text Link to item Cite

Human uterine leiomyoma-derived fibroblasts stimulate uterine leiomyoma cell proliferation and collagen type I production, and activate RTKs and TGF beta receptor signaling in coculture.

Journal Article Cell Commun Signal · June 10, 2010 BACKGROUND: Uterine leiomyomas (fibroids) are benign smooth muscle tumors that often contain an excessive extracellular matrix (ECM). In the present study, we investigated the interactions between human uterine leiomyoma (UtLM) cells and uterine leiomyoma- ... Full text Open Access Link to item Cite

Natural history of biologically malignant struma ovarii: analysis of 27 cases with extraovarian spread.

Journal Article Int J Gynecol Pathol · May 2010 The natural history of 27 cases of biologically malignant struma ovarii from a series of 88 cases of histologically malignant or histologically proliferative struma ovarii is described. The extraovarian spread was evident at presentation in 17 patients. Th ... Full text Link to item Cite

Isolated and synchronous vulvar granular cell tumors: a clinicopathologic study of 17 cases in 13 patients.

Journal Article Int J Gynecol Pathol · March 2010 Granular cell tumors (GCTs) are benign Schwann cell-derived neoplasms occurring throughout the body. Vulvar GCTs are usually isolated, but occasionally multifocal. On account of their anatomic location, surgical interventions aiming for negative resection ... Full text Link to item Cite

Paget disease of the vulva: a study of 56 cases.

Journal Article Eur J Obstet Gynecol Reprod Biol · March 2010 OBJECTIVE: To resolve controversial issues regarding vulvar Paget disease through analysis of a substantial number of cases. STUDY DESIGN: The medical records and pathology slides of 56 patients with a diagnosis of vulvar Paget disease were reviewed. Possi ... Full text Link to item Cite

Paget Disease of the Vulva - A Study of 56 Cases

Conference LABORATORY INVESTIGATION · February 1, 2010 Link to item Cite

Paget disease of the vulva: a histologic study of 56 cases correlating pathologic features and disease course.

Journal Article Int J Gynecol Pathol · January 2010 The Duke experience with 56 vulvar Paget disease patients was analyzed emphasizing pathologic features and controversial issues. Nearly all patients were Caucasian, and their mean age was 69 years. The average length of follow-up was 5.6 years. For each ca ... Full text Link to item Cite

Paget Disease of the Vulva - A Study of 56 Cases

Conference MODERN PATHOLOGY · 2010 Cite

Malignant struma ovarii: an analysis of 88 cases, including 27 with extraovarian spread.

Journal Article Int J Gynecol Pathol · September 2009 Struma ovarii that display extraovarian spread or later recurrence is exceedingly rare. Among 88 patients with "malignant" struma ovarii followed for prolonged periods, several features helped to predict the adverse clinical course. Adhesions (graded 2 to ... Full text Link to item Cite

Schistosomiasis and vesicovaginal fistula.

Journal Article Afr J Reprod Health · September 2009 Schistosoma haematobium is presented as a cause of vesicovaginal fistula in a nulliparous adolescent. The possible role of S. haematobium in failure of fistula repair and the importance of screening and treatment in endemic areas prior to repair are discus ... Link to item Cite

p16 Improves interobserver agreement in diagnosis of anal intraepithelial neoplasia.

Journal Article J Low Genit Tract Dis · July 2009 OBJECTIVES: Evaluation of anal intraepithelial neoplasia (AIN) is subjective. Previous studies have shown p16 and Ki-67 expressions to correlate with AIN grade. Biomarkers like p16 and Ki-67 may improve interobserver agreement. The objectives were (1) to d ... Full text Link to item Cite

Breast cancer screening in women exposed in utero to diethylstilbestrol.

Journal Article J Womens Health (Larchmt) · April 2009 PURPOSE: To determine if women exposed in utero to diethylstilbestrol (DES) are more likely than unexposed women to receive recommended or additional breast cancer screening examinations. METHODS: 1994 Diethylstilbestrol-Adenosis (DESAD) cohort data are us ... Full text Link to item Cite

The villous stromal constituents of complete hydatidiform mole differ histologically in very early pregnancy from the normally developing placenta.

Journal Article Am J Surg Pathol · February 2009 Featured Publication Histologic distinction between complete hydatidiform moles and nonmolar abortuses in early pregnancy is often extremely difficult. This study details the chronologic changes that occur in normal placenta, especially in the villous stroma during gestational ... Full text Link to item Cite

Introduction

Chapter · 2009 Full text Cite

Cervical screening and general physical examination behaviors of women exposed in utero to diethylstilbestrol.

Journal Article J Low Genit Tract Dis · April 2008 Featured Publication OBJECTIVE: To estimate whether women exposed in utero to diethylstilbestrol (DES) report receiving more cervical and general physical examinations compared to unexposed women. MATERIALS AND METHODS: 1994 Diethylstilbestrol Adenosis cohort data are used to ... Full text Link to item Cite

The association between in utero cigarette smoke exposure and age at menopause.

Journal Article Am J Epidemiol · March 15, 2008 Featured Publication Menopause onset, on average, occurs earlier among women who smoke cigarettes than among women who do not smoke. Prenatal smoke exposure may also influence age at menopause through possible effects on follicle production in utero. Smoking information was ob ... Full text Link to item Cite

Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas.

Journal Article Mol Med · 2008 Featured Publication Uterine leiomyomas (fibroids) are benign tumors that are prevalent in women of reproductive age. Research suggests that activated receptor tyrosine kinases (RTKs) play an important role in the enhanced proliferation observed in fibroids. In this study, a p ... Full text Link to item Cite

A primer of endometrial cytology with histological correlation.

Journal Article Diagn Cytopathol · December 2007 Featured Publication Cytology is an effective method for assessing benign endometrium and for discovering premalignant and malignant endometrial states. In addition, it is useful for diagnosing non-neoplastic abnormalities of the endometrium. This overview compares endometrial ... Full text Link to item Cite

Designing the "next generation" of medical information systems

Journal Article Proceedings - 9th International Conference on Information Technology, ICIT 2006 · November 16, 2007 A new breed of medical information systems is required to more effectively address unresolved and newly emerging needs in the healthcare environment. This paper attempts to define those needs and describe the design and implementation of a solution. In ord ... Full text Cite

Cancer risk in women prenatally exposed to diethylstilbestrol.

Journal Article Int J Cancer · July 15, 2007 Featured Publication Prenatal diethylstilbestrol (DES) exposure is associated with excess risks of clear cell adenocarcinoma (CCA), and breast cancer in older women. Whether overall cancer risk is also elevated is unclear. Total and site-specific cancer risks were evaluated in ... Full text Link to item Cite

Preeclampsia risk in women exposed in utero to diethylstilbestrol.

Journal Article Obstet Gynecol · July 2007 Featured Publication OBJECTIVE: To assess whether preeclampsia risk is elevated in pregnancies of diethylstilbestrol (DES)-exposed daughters. METHODS: This study used data from the National Cancer Institute DES Combined Cohorts Follow-up Study. A total of 285 preeclampsia case ... Full text Link to item Cite

Is stromal microinvasion in primary mucinous ovarian tumors with "mucin granuloma" true invasion?

Journal Article Am J Surg Pathol · April 2007 Stromal microinvasion has been recently described in ovarian mucinous borderline tumors (MBTs), leading to proposals for new classifications, including a category of MBTs with stromal microinvasion. This study was conducted to test the validity of this bel ... Full text Link to item Cite

Benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasia.

Journal Article Int J Gynecol Pathol · April 2007 Featured Publication Endometrial "hyperplasia," as currently diagnosed, includes the changes caused by an abnormal hormonal state and those caused by a separate category of monoclonal premalignant disease. The appearance of the disease in these 2 functional categories is disco ... Full text Link to item Cite

Neoplasms and pathology of sexual developmental disorders (intersex).

Journal Article Pathology · February 2007 Featured Publication Continuing new insights into the biology of sexual development and advances in chromosome analysis have led to early identification and prompt treatment of the intersexual patient, the results of which facilitate a more normal life for affected individuals ... Full text Link to item Cite

Silent corticotroph cell pituitary adenoma in a struma ovarii.

Journal Article Int J Gynecol Pathol · January 2007 This is the first report of a silent corticotroph cell pituitary adenoma arising in a struma ovarii. The patient, a 79-year-old woman, was found to have an asymptomatic left-sided adnexal mass confirmed by vaginal sonography to be a complex cystic and soli ... Full text Link to item Cite

Dynamic behavioural interpretation of cervical intraepithelial neoplasia with molecular biomarkers.

Journal Article J Clin Pathol · October 2006 Featured Publication The microscopic phenotype of cervical intraepithelial neoplasia (CIN) reflects a fine balance between factors that promote or reduce CIN development. A shortcoming of the current grading system is its reliance on static morphology and microscopic haematoxy ... Full text Link to item Cite

Age at natural menopause in women exposed to diethylstilbestrol in utero.

Journal Article Am J Epidemiol · October 1, 2006 Age at natural menopause is related to several health outcomes, including cardiovascular disease and overall mortality. Age at menopause may be influenced by the number of follicles formed during gestation, suggesting that prenatal factors could influence ... Full text Link to item Cite

Birth weight and breast cancer risk.

Journal Article Br J Cancer · June 5, 2006 Exploring whether the positive association between birth weight and breast cancer risk differs by other breast cancer risk factors may help inform speculation about biological mechanism. In these data, high birth weight was associated with breast cancer ri ... Full text Link to item Cite

Transtubal spread of serous adenocarcinoma of the endometrium: an underrecognized mechanism of metastasis.

Journal Article Int J Gynecol Pathol · April 2006 Featured Publication Most endometrial carcinomas metastasize by invading myometrial lymphatics and spreading to regional lymph nodes. However, uterine serous carcinomas (USCs) metastasize frequently to peritoneal surfaces even when only minimally invasive. This study examines ... Full text Link to item Cite

Lymphoma of the female genital tract: current status.

Journal Article Int J Gynecol Pathol · January 2006 Featured Publication : Primary lymphomas affecting the female reproductive system are uncommon but often pose a diagnostic challenge if their existence is not suspected. This article reviews the pathological and clinical features of lymphomas occurring in various sites in the ... Full text Link to item Cite

Differential expression of p63 isoforms in female reproductive organs.

Journal Article Mech Dev · September 2005 Featured Publication p63 is the identity switch for uterine/vaginal epithelial cell fate, and disruption of p63 expression by diethylstilbestrol (DES) induces cervical/vaginal adenosis in mice. In this article, we report the expression patterns of p63 isoforms (TA, DeltaN, alp ... Full text Link to item Cite

Combined p53 and retinoblastoma protein detection identifies persistent and regressive cervical high-grade squamous intraepithelial lesions.

Journal Article Am J Surg Pathol · August 2005 Most cervical high-grade squamous intraepithelial lesions (HSILs) persist, but approximately one third regress (ie, no HSIL in follow-up biopsies). To identify factors related to histologic proven persistence or regression. Twenty-eight small histologic (m ... Link to item Cite

Hypospadias in sons of women exposed to diethylstilbestrol in utero.

Journal Article Epidemiology · July 2005 BACKGROUND: Diethylstilbestrol (DES) is a synthetic estrogen that was widely prescribed to pregnant women before 1971. DES increases the risk of breast cancer in women who took the drug and the risk of reproductive tract abnormalities in their offspring. D ... Full text Link to item Cite

The molecular genetics and morphometry-based endometrial intraepithelial neoplasia classification system predicts disease progression in endometrial hyperplasia more accurately than the 1994 World Health Organization classification system.

Journal Article Cancer · June 1, 2005 BACKGROUND: The objective of this study was to compare the accuracy of disease progression prediction of the molecular genetics and morphometry-based Endometrial Intraepithelial Neoplasia (EIN) and World Health Organization 1994 (WHO94) classification syst ... Full text Link to item Cite

Risk of benign gynecologic tumors in relation to prenatal diethylstilbestrol exposure.

Journal Article Obstet Gynecol · January 2005 OBJECTIVE: To investigate the association between prenatal diethylstilbestrol (DES) exposure and risk of benign gynecologic tumors. METHODS: We conducted a collaborative follow-up study of women with and without documented intrauterine exposure to DES. We ... Full text Link to item Cite

Interobserver and intraobserver variability in the histological dating of the endometrium in fertile and infertile women.

Journal Article Fertil Steril · November 2004 OBJECTIVE: To assess effects of biopsy timing and fertility status on inter- and intraobserver variability in dating of the endometrium. DESIGN: Endometrial biopsy slides randomly selected from a multicenter study testing the utility of biopsy in the diagn ... Full text Link to item Cite

An abnormal cervicovaginal cytology smear in uterine carcinosarcoma is an adverse prognostic sign: analysis of 25 cases.

Journal Article Am J Clin Pathol · September 2004 Carcinosarcoma of the uterus has been poorly characterized on cervicovaginal (Pap) smears, and we examine whether they effectively screen for carcinosarcoma and whether an abnormal Pap smear result has any clinical importance. Twenty-five patients with his ... Full text Link to item Cite

A diagnostically useful histopathologic feature of endometrial polyp: the long axis of endometrial glands arranged parallel to surface epithelium.

Journal Article Am J Surg Pathol · August 2004 Featured Publication We describe a histologic feature useful in the diagnosis of endometrial polyps, namely, the parallel arrangement of the endometrial glands' long axis to the surface epithelium (PGE). Polyps that are removed intact are usually easy to diagnose because of th ... Full text Link to item Cite

Mucinous adenocarcinoma arising in rectovaginal fistulas associated with Crohn's disease.

Journal Article Gynecol Oncol · April 2004 Featured Publication BACKGROUND: Crohn's disease is a chronic inflammatory disorder characterized by focal, transmural inflammation of the intestine. Gynecologic involvement, including rectovaginal fistula formation, is frequent. Case #1. A 53-year-old female with a 30-year hi ... Full text Link to item Cite

Placental site trophoblastic tumor arising from antecedent molar pregnancy.

Journal Article Gynecol Oncol · February 2004 Featured Publication OBJECTIVE: Placental site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic disease. Little is known about its pathogenesis and natural history. METHODS: This report describes two cases that arose in patients with documented complete h ... Full text Link to item Cite

Ki67 predicts progression in early CIN: validation of a multivariate progression-risk model.

Journal Article Cell Oncol · 2004 This study of early CIN biopsies (25 CIN1 and 65 CIN2) with long follow-up was done to validate, in a new group of patients, the value of Ki67 immuno-quantitative features to predict high CIN grade in a follow-up biopsy (often denoted to as "progression"), ... Full text Link to item Cite

Prognostic value and reproducibility of koilocytosis in cervical intraepithelial neoplasia.

Journal Article Int J Gynecol Pathol · July 2003 Featured Publication The purpose of this study was to evaluate the influence of koilocytosis on the progression of cervical intraepithelial neoplasia (CIN) to a higher grade during follow-up in cervical biopsy specimens with CIN 1 and 2. In adequate, consecutive, biopsy specim ... Full text Link to item Cite

Embolic microspheres within ovarian arterial vasculature after uterine artery embolization.

Journal Article Obstet Gynecol · November 2002 Featured Publication BACKGROUND: Adverse events after uterine artery embolization, including hysterectomy and premature ovarian failure, are concerning for women who desire future fertility. CASE: A 39-year-old woman underwent emergency hysterectomy after uterine artery emboli ... Full text Link to item Cite

Mosaicism and endometrial adenocarcinoma in an adult Turner syndrome patient.

Conference AMERICAN JOURNAL OF HUMAN GENETICS · October 1, 2002 Link to item Cite

Cell proliferation and apoptosis in human uterine leiomyomas and myometria.

Journal Article Virchows Arch · July 2002 Featured Publication To determine the role of cell proliferation and apoptosis in uterine leiomyoma growth, we studied protein expression of two major regulatory proteins of apoptosis -- Bcl-2 (anti-apoptotic) and Bax (pro-apoptotic) -- and two endogenous markers of cell repli ... Full text Link to item Cite

Incidence of squamous neoplasia of the cervix and vagina in women exposed prenatally to diethylstilbestrol (United States).

Journal Article Cancer Causes Control · November 2001 Featured Publication OBJECTIVES: Women exposed prenatally to diethylstibestrol (DES) have an excess risk of clear-cell adenocarcinoma of the vagina and cervix, but the effect on the incidence of squamous neoplasia is uncertain. The purpose of the current study was to evaluate ... Full text Link to item Cite

Cancer risk in men exposed in utero to diethylstilbestrol.

Journal Article J Natl Cancer Inst · April 4, 2001 Featured Publication BACKGROUND: An association between prenatal diethylstilbestrol (DES) exposure and cancer in men, especially testicular cancer, has been suspected, but findings from case-control studies have been inconsistent. This study was conducted to investigate the as ... Full text Link to item Cite

Malignancy in endometriosis: frequency and comparison of ovarian and extraovarian types.

Journal Article Int J Gynecol Pathol · April 2001 Featured Publication One thousand consecutive cases of surgically proven endometriosis were reviewed to evaluate the frequency and types of pelvic cancers that were associated with ovarian and extraovarian endometriosis. The frequency and types of histologic abnormalities pres ... Full text Link to item Cite

K-ras mutations in Müllerian inclusion cysts associated with serous borderline tumors of the ovary.

Journal Article Gynecol Oncol · February 2001 Featured Publication OBJECTIVE: Müllerian inclusion cysts (MIC) are small benign appearing glands that are occasionally noted in lymph nodes and peritoneal biopsies. They occur most frequently in women with serous ovarian tumors, with borderline tumors (SBOT) having a higher i ... Full text Link to item Cite

A double-blind randomized study on the effects of red clover isoflavones on the endometrium.

Journal Article Menopause · 2001 OBJECTIVE: To assess the effects of a red clover-derived isoflavone extract on the Ki-67 proliferative marker of endometrial biopsies in 45-to 50-year-old perimenopausal women. We hypothesized that we would be able to detect a decrease in the Ki-67 prolife ... Full text Link to item Cite

BOOK REVIEWS.

Journal Article Int J Gynecol Pathol · January 2001 Featured Publication Link to item Cite

Pathology and pathophysiology of uterine smooth-muscle tumors.

Journal Article Environ Health Perspect · October 2000 Featured Publication Smooth-muscle tumors of uterine origin encompass a broad family of neoplasms. The leiomyoma, by far the most common of all the neoplasms, generally is hormone sensitive, with rates of growth semiquantitatively related to estrogen and progesterone receptor ... Full text Link to item Cite

Bladder cancer: race differences in extent of disease at diagnosis.

Journal Article Cancer · September 15, 2000 Featured Publication BACKGROUND: Blacks are less likely than whites to develop bladder cancer; although once diagnosed, blacks experience poorer survival. This study sought to examine multiple biological and behavioral factors and their influence on extent of disease. METHODS: ... Full text Link to item Cite

Some mullerian inclusion cysts in lymph nodes may sometimes be metastases from serous borderline tumors of the ovary.

Journal Article Am J Surg Pathol · May 2000 Featured Publication Glandular inclusions that appear morphologically benign are occasionally found in lymph nodes as well as in peritoneal and omental biopsies. In patients with gynecologic malignancies, the nature and significance of these mullerian inclusion cysts (MIC) pre ... Full text Link to item Cite

The outcome of stage I-II clinically and surgically staged papillary serous and clear cell endometrial cancers when compared with endometrioid carcinoma.

Journal Article Gynecol Oncol · April 2000 Featured Publication PURPOSE: The aim of this study was to compare survival and recurrence in clinical and surgical stage I-II papillary serous (PS), clear cell (CC), and endometrioid (EM) cancers of the endometrium and examine the prognostic utility of myometrial invasion. ME ... Full text Link to item Cite

Epidemiologic and surgicopathologic findings of papillary serous and clear cell endometrial cancers when compared to endometrioid carcinoma.

Journal Article Gynecol Oncol · September 1999 PURPOSE: The aim of this study was to identify similarities and differences in epidemiologic and surgicopathologic staging results for papillary serous (PS) and clear cell (CC) endometrial cancers compared with endometrioid (EM) carcinoma of the endometriu ... Full text Link to item Cite

Progesterone receptor activity in leiomyomatosis peritonealis disseminata.

Journal Article Int J Gynecol Pathol · July 1999 Leiomyomatosis peritonealis disseminata (LPD) is a rare condition that primarily affects women of reproductive age. Immunohistochemical studies were performed in four cases: LPD from a premenopausal woman on oral contraceptives (one case); LPD associated w ... Full text Link to item Cite

Goblet-cell mucinous epithelium lining the endometrium and endocervix: evidence of metastasis from an appendiceal primary tumor through the use of cytokeratin-7 and -20 immunostains.

Journal Article Int J Gynecol Pathol · October 1998 Differential staining with cytokeratin (CK)-7 and CK-20, two members of a complex family of proteins in human epithelial cells, proved critical in showing that the extremely well-differentiated goblet-cell (intestinal) mucinous epithelium lining the surfac ... Full text Link to item Cite

Cancer risk in women exposed to diethylstilbestrol in utero.

Journal Article JAMA · August 19, 1998 CONTEXT: The association between in utero exposure to diethylstilbestrol (DES) and clear cell adenocarcinoma (CCA) of the vagina and cervix is well known, yet there has been no systematic study of DES-exposed daughters to determine whether they have an inc ... Full text Link to item Cite

Signet-ring cell carcinoma of the endometrium: a primary tumor masquerading as a metastasis.

Journal Article Int J Gynecol Pathol · April 1997 Extragenital metastases to the endometrium are unusual, but several histologic features have been suggested as highly suggestive or even pathognomonic for this diagnosis. We report an endometrial carcinoma with a prominent signet-ring cell morphology and a ... Full text Link to item Cite

Aetiology and histopathology of endometrial hyperplasia and carcinoma

Journal Article Current Obstetrics and Gynaecology · January 1, 1997 Endometrial hyperplasias and many endometrial carcinomas are the result of over-stimulation of the endometrium by oestrogens. Hyperplasias are classified as simple, complex or atypical, the terms 'simple' and 'complex' referring to the glandular architectu ... Full text Cite

Epithelial repair of the uterine cervix: assessment of morphologic features and correlations with cytologic diagnosis.

Journal Article Int J Gynecol Pathol · October 1996 This study evaluates the morphologic features of squamous epithelial repair of the uterine cervix, a condition describing a state of regeneration, and compares them with the features of its two histologic mimics, squamous metaplasia and mild dysplasia. The ... Full text Link to item Cite

Prospective correlation of cervicovaginal cytologic and histologic specimens.

Journal Article Am J Clin Pathol · September 1996 An effective, prospective, computer-guided method of correlation is reported. The mechanism for identification of cases, comparison of diagnoses, and reconciliation of discrepancies are explained. The results are similar to prior, retrospective, correlatio ... Full text Link to item Cite

Differences between black and white patients with cancer of the uterine corpus in interval from symptom recognition to initial medical consultation (United States).

Journal Article Cancer Causes Control · May 1996 To determine whether Black women with symptoms of uterine corpus cancer had longer times from symptom recognition to initial medical consultation than did White women in the United States, 331 newly diagnosed patients living in Atlanta (GA), New Orleans (L ... Full text Link to item Cite

Postsurgical surveillance of patients with FIGO stage I/II endometrial adenocarcinoma.

Journal Article Gynecol Oncol · October 1995 OBJECTIVE: To examine the effect of postsurgical surveillance on survival of patients with FIGO stage I/II endometrial adenocarcinoma. METHODS: We examined the records of 354 patients who underwent primary surgical therapy for FIGO stage I/II endometrial a ... Full text Link to item Cite

Endometrial cancer: stage at diagnosis and associated factors in black and white patients.

Journal Article Am J Obstet Gynecol · August 1995 OBJECTIVE: This study examined the relationship of clinicopathologic, health status, medical system, and socioeconomic factors to differences in stage at diagnosis of endometrial cancer in black and white patients. STUDY DESIGN: A population-based study of ... Full text Link to item Cite

Racial differences in tumor grade among women with endometrial cancer.

Journal Article Gynecol Oncol · February 1995 Black women with endometrial cancer have more advanced disease and less favorable tumor grade than do white women. This study evaluated whether racial differences in tumor grade could be explained by hormone-related factors and other putative determinants ... Full text Link to item Cite

Borderline and malignant serous tumor arising in pelvic lymph nodes: evidence of origin in benign glandular inclusions.

Journal Article Int J Gynecol Pathol · January 1995 This report describes two cases of malignant serous cancers with areas of borderline malignancy, which appear to have arisen within benign glandular inclusions of coelomic origin in pelvic or para-aortic lymph nodes. The patients were 44 and 62 years of ag ... Full text Link to item Cite

Vaginal administration of low-dose conjugated estrogens: systemic absorption and effects on the endometrium.

Journal Article Obstet Gynecol · August 1994 OBJECTIVE: To test the hypothesis tha a very-low-dose regimen of vaginal estrogen would provide effective relief from atrophic vaginitis without endometrial proliferation. METHODS: Twenty postmenopausal women with symptoms, signs, and cytologic evidence of ... Link to item Cite

Pathology of epithelial ovarian tumors.

Journal Article Clin Obstet Gynecol · June 1994 Full text Link to item Cite

Synoptic reports in gynecologic pathology.

Journal Article Int J Gynecol Pathol · April 1994 Full text Link to item Cite

Overexpression of p53 is not a feature of benign and early-stage borderline epithelial ovarian tumors.

Journal Article Gynecol Oncol · February 1994 Since overexpression of mutant p53 protein is a common feature of invasive epithelial ovarian cancers, we investigated whether overexpression of the p53 tumor suppressor gene product occurs in benign and borderline epithelial ovarian tumors. Immunohistoche ... Full text Link to item Cite

An ultrastructural study of the developing urogenital tract in early human fetuses.

Journal Article Am J Obstet Gynecol · July 1992 OBJECTIVES: This study examines the gonoducts during the ambisexual stage of human fetal development to define their ultrastructural characteristics, including the origin and antomic relationship of the mesonephric and paramesonephric ducts during gonoduct ... Full text Link to item Cite

The gelatinous bone marrow (serous atrophy) in patients with acquired immunodeficiency syndrome. Evidence of excess sulfated glycosaminoglycan.

Journal Article Arch Pathol Lab Med · May 1992 Patients with the acquired immunodeficiency syndrome uniformly exhibit hematologic abnormalities characterized by anemia and/or pancytopenia. In a study of 75 consecutive bone marrow biopsy specimens from patients with acquired immunodeficiency syndrome, 2 ... Link to item Cite

Selected topics in the pathology of the vagina.

Journal Article Hum Pathol · September 1991 Full text Link to item Cite

The diagnosis of ovarian cancer by pathologists: how often do diagnoses by contributing pathologists agree with a panel of gynecologic pathologists?

Journal Article Am J Obstet Gynecol · January 1991 The Cancer and Steroid Hormone Study, a multicenter, population-based, case-control study of ovarian, breast, and endometrial cancer in women 20 to 54 years of age, permitted the diagnoses of contributing pathologists to be compared with those of a panel o ... Full text Link to item Cite

Sarcoidosis of the uterus.

Journal Article Arch Pathol Lab Med · August 1989 The present case of sarcoidosis of the uterus and the previously reported cases are reviewed. Uterine sarcoidosis is usually detected during the investigation of abnormal uterine bleeding in patients with prior evidence of sarcoidosis in another site. Howe ... Link to item Cite

Impaired bone marrow in AIDS.

Journal Article N J Med · August 1989 Fifty bone marrows from patients with AIDS were studied to identify the abnormalities related to marrow failure. Prominent reticulin fibrosis and increased atypical megakaryocytes were the major changes associated with the aberrant hematopoietic microenvir ... Link to item Cite

Chlamydia trachomatis.

Journal Article N J Med · April 1989 The frequency of positive serological tests for Chlamydia trachomatis, the most common sexually transmitted pathogen in the United States, was assessed in 18,622 specimens derived from New Jersey clinics. From the results, 13 percent female patients and 17 ... Link to item Cite

Human papillomavirus infection. Frequency and association with cervical neoplasia in a young population.

Journal Article Acta Cytol · 1989 One million, six hundred thirty-two thousand, eight hundred forty-seven women from two independent populations in the United States received cytologic screening during a two-year period. Condylomatous lesions (human papillomavirus [HPV] infections) were th ... Link to item Cite

Statistical methods for morphometric analysis

Journal Article IEEE/Engineering in Medicine and Biology Society Annual Conference · November 1, 1988 Statistical procedures and software packages appropriate for the analysis of morphometric data are discussed. In a typical situation, morphometry is used to provide an objective system of measures, which along with various demographic data can be used to p ... Cite

Computer-aided morphometric applications (image analysis) in gynecologic pathology

Journal Article IEEE/Engineering in Medicine and Biology Society Annual Conference · November 1, 1988 The female genital tract gives rise to a wide spectrum of disease entities that are borderline abnormal on the one hand or borderline cancer on the other. While traditional criteria have been developed for the diagnosis of these lesions, based on cytologic ... Cite

Absence of teratogenic effects of progesterone on the developing genital tract of the human female fetus.

Journal Article Hum Pathol · July 1988 It has been questioned whether prenatal exposure to progesterone, like exposure to diethylstilbestrol (DES), results in teratogenic abnormalities of the upper and lower genital tract in human females. Through the use of a recently described model in which ... Full text Link to item Cite

Prevalence of dysplasia and cancer of the cervix in a nationwide, planned parenthood population.

Journal Article Cancer · June 1, 1988 Two and three-tenths percent of cervical smears disclosed abnormalities from among 1,045,059 submitted for processing and examination by the Cancer Screening Service. The smears came from 198 Planned Parenthood Family Planning Clinics in 23 States during a ... Full text Link to item Cite

Hysterectomy, tubal sterilization, and the risk of breast cancer.

Journal Article Am J Epidemiol · June 1988 Studies suggest that hysterectomy and tubal sterilization may alter the function of the remaining ovaries. Conceivably, this effect could alter breast cancer risk. To investigate whether these surgeries affect breast cancer risk, the authors analyzed data ... Full text Link to item Cite

Clear cell adenocarcinoma of the vagina and cervix: incidence, undetected disease, and diethylstilbestrol.

Journal Article J Clin Epidemiol · 1988 We conducted an incidence study to determine the occurrence rates of clear cell adenocarcinoma (CCAC) of the vagina and cervix in young women (born in 1940 and thereafter), and a case-series analysis, focusing on the maternal history of pregnancy and deliv ... Full text Link to item Cite

Teratogenic effects of clomiphene, tamoxifen, and diethylstilbestrol on the developing human female genital tract.

Journal Article Hum Pathol · November 1987 The potential estrogenicity and teratogenicity of triphenylethylene antiestrogens were examined in 54 genital tracts isolated from 4- to 19-week-old human female fetuses and grown for 1 to 2 months in untreated athymic nude mice or host mice treated by sub ... Full text Link to item Cite

The acquired immunodeficiency syndrome in intravenous drug abusers and patients with a sexual risk: clinical and postmortem comparisons.

Journal Article Hum Pathol · November 1987 Clinical and necropsy findings in 13 intravenous drug abusers who died of the acquired immunodeficiency syndrome (AIDS) were reviewed and compared with findings in eight patients who acquired the infection through sexual exposure, the most common mode of t ... Full text Link to item Cite

Coital risk factors for cervical cancer. Sexual activity among white middle class women.

Journal Article Am J Clin Oncol · June 1987 This study reports the sexual history of a group of young women participating in an epidemiologic project. The methods used to recruit and interview the participants minimized self-selection bias. Results of over 11,000 interviews with 1,892 participants s ... Full text Link to item Cite

Neural and neuroendocrine tumors of the larynx

Journal Article Annals of Otology, Rhinology and Laryngology · 1987 Benign and malignant neural and neuroendocrine tumors of the larynx are uncommon enough that knowledge about them is sparse, coming from single case reports and literature reviews. We have reviewed the clinical behavior, pathologic findings, treatment, and ... Cite

Endodermal sinus tumor (yolk sac tumor) of the ear

Journal Article Archives of Otolaryngology - Head and Neck Surgery · 1987 Endodermal sinus tumors (yolk sac tumors) are malignant germ cell tumors that usually arise in the gonads. We report what is, to our knowledge, the first known case of endodermal sinus tumor of the ear. The tumor was present in in a developmentally delayed ... Cite

ULTRASTRUCTURAL-STUDY OF DEVELOPING UROGENITAL TRACT IN EARLY HUMAN FETUSES

Journal Article LABORATORY INVESTIGATION · January 1, 1987 Link to item Cite

Expression of nuclear estrogen-binding sites within developing human fetal vagina and urogenital sinus.

Journal Article Am J Anat · December 1986 An autoradiographic study of nuclear estrogen binding was performed in developing human urogenital sinuses and vaginas derived from first and second trimester specimens. Nuclear estrogen binding was detected in all specimens greater than or equal to 10 wee ... Full text Link to item Cite

Pulmonary cytology of the acquired immune deficiency syndrome: an analysis of 36 cases.

Journal Article Diagn Cytopathol · September 1986 The infectious pathogens and associated cellular reactions in 75 pulmonary cytological specimens obtained largely by fiberoptic bronchoscopy from 36 patients with the acquired immune deficiency syndrome are described and correlated with the biopsy specimen ... Full text Link to item Cite

Vaginal adenosis in women born prior to the diethylstilbestrol era.

Journal Article Hum Pathol · May 1986 Vaginal adenosis was evaluated in 41 women, all of whom had been born prior to the diethylstilbestrol (DES) era, and compared with the adenosis commonly encountered in DES-exposed progeny. The patients were 24 to 88 years of age (median, 44 years). Six of ... Full text Link to item Cite

THE INCIDENCE OF CERVICAL AND VAGINAL DYSPLASIA AFTER EXPOSURE TO DES - REPLY

Journal Article JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION · 1986 Full text Cite

Infantile chlamydial conjunctivitis. A comparison of Papanicolaou, Giemsa and immunoperoxidase staining methods.

Journal Article Acta Cytol · 1986 The use of conjunctival smears to diagnose infantile Chlamydia trachomatis infection increased sixteen-fold in our hospital between the years 1979 and 1984. The present study was conducted to compare Papanicolaou and Giemsa staining methods with the avidin ... Link to item Cite

The incidence of cervical and vaginal dysplasia after exposure to DES

Journal Article Journal of the American Medical Association · 1986 Cite

Female adnexal tumor of probable Wolffian origin with multiple recurrences over 16 years.

Journal Article Cancer · September 15, 1985 The case history of a woman with a "female adnexal tumor of probable Wolffian origin" is described in which the neoplasm recurred three times during a 16-year interval and responded with prolonged remission after repeated surgical excision and radiotherapy ... Full text Link to item Cite

Pathology of colposcopic findings in 2635 diethylstilbestrol-exposed young women.

Journal Article Gynecol Oncol · July 1985 An analysis of 6055 colposcopically directed biopsy specimens from 2635 diethylstilbestrol (DES)-exposed women and 445 biopsy specimens from 277 nonexposed women was undertaken to correlate microscopic findings with colposcopic patterns. All examinations w ... Full text Link to item Cite

Increased incidence of cervical and vaginal dysplasia in 3980 diethylstilbestrol-exposed young women: Experience of the national collaborative diethylstilbestrol adenosis project

Journal Article Obstetrical and Gynecological Survey · January 1, 1985 The purpose of this article is to report the incident cases of intraepithelial neoplasia of the cervix and vagina among patients in the National Collaborative Diethylstilbestrol Ad-enosis Project. Incidence rates for dysplasia/carcinoma in situ have been c ... Full text Cite

Diethylstilbestrol and its consequences: Status in 1985

Journal Article Cervix and the Lower Female Genital Tract · January 1, 1985 Cite

Increased incidence of cervical and vaginal dysplasia in 3,980 diethylstilbestrol-exposed young women. Experience of the National Collaborative Diethylstilbestrol Adenosis Project.

Journal Article JAMA · December 7, 1984 The incidence rates of dysplasia and carcinoma in situ (CIS) of the cervix and vagina were determined in 3,980 young women exposed prenatally to diethylstilbestrol. Strict criteria were developed to minimize selection bias among the subset of 744 pairs of ... Link to item Cite

Timing and irreversibility of Müllerian duct inhibition in the embryonic reproductive tract of the human male.

Journal Article Dev Biol · December 1984 A study was undertaken to determine (1) the effects of endogenous Müllerian inhibiting substance (MIS) on the developing human fetal genital tract; (2) the time in fetal life when MIS is first capable of inhibiting the growth of the embryonic Müllerian duc ... Full text Link to item Cite

Insular carcinoid of ovary associated with malignant mucinous tumors.

Journal Article Cancer · November 15, 1984 Ovarian carcinoids are frequently encountered in association with mucinous cysts and occasionally with mucinous cystadenomas. From a series of more than 200 ovarian carcinoids, this report describes 2 cases of insular carcinoid, 1 of which arose in a cysta ... Full text Link to item Cite

Low-dose preoperative radiation therapy for adenocarcinoma of the endometrium. A pilot study.

Journal Article Cancer · September 15, 1984 A pilot study using low-dose preoperative radiation therapy, i.e., 10 Gy in 3 to 4 days as an adjuvant preoperative procedure for grade 2 or 3 (FIGO classification) endometrial carcinoma, was done. The concept of low-dose preoperative radiation therapy is ... Full text Link to item Cite

Atypical vaginal adenosis and cervical ectropion. Association with clear cell adenocarcinoma in diethylstilbestrol-exposed offspring.

Journal Article Cancer · September 1, 1984 Knowledge of the evolution of clear cell adenocarcinomas of the vagina and cervix in diethylstilbestrol-exposed progeny has remained elusive despite the known topographical association of these tumors with the tuboendometrial form of vaginal adenosis and c ... Full text Link to item Cite

Are metaplasias in colorectal adenomas truly metaplasias?

Journal Article Am J Pathol · May 1984 Five thousand seven hundred seventy-eight adenomas or adenomas containing carcinoma from 3215 patients were examined by routine histologic methods for the presence of epithelial metaplasias. Three forms of epithelial metaplasia were encountered: squamous c ... Link to item Cite

Structural anomalies of the cervix and vagina in women enrolled in the Diethylstilbestrol Adenosis (DESAD) Project.

Journal Article Am J Obstet Gynecol · January 1, 1984 Among women exposed in utero to diethylstilbestrol (DES) and enrolled in the Diethylstilbestrol Adenosis (DESAD) Project, structural anomalies of the cervix or vagina were found in 25% of the 1,655 subjects identified by review of prenatal records, 43% of ... Full text Link to item Cite

Evaluation of squamous epithelium in adenoacanthoma and adenosquamous carcinoma of the endometrium: immunoperoxidase analysis of involucrin and keratin localization.

Journal Article Int J Gynecol Pathol · 1984 A study was undertaken to determine whether immunoperoxidase stains for keratin and involucrin, the latter a protein present in cells of stratified squamous epithelium that have differentiated beyond the basal stage, distinguish any differences in squamous ... Full text Link to item Cite

Lymphomas or leukemia presenting as ovarian tumors. An analysis of 42 cases.

Journal Article Cancer · November 15, 1983 Forty cases of ovarian lymphoma and two of extramedullary leukemia were examined with emphasis on histologic types correlated with age, modes of presentation, operative findings, including frequency of bilaterality and omental spread, clinical course follo ... Full text Link to item Cite

Histologic, nuclear DNA, and human papillomavirus studies of cervical condylomas.

Journal Article Cancer · November 1, 1983 Fifty-four cervical condylomatous lesions, with and without nuclear atypia, from 42 women, were studied with the Feulgen microspectrophotometric technique for nuclear DNA quantitation and an immunoperoxidase technique for human papillomavirus (HPV) antigen ... Full text Link to item Cite

Maturation of vaginal and cervical epithelium in women exposed in utero to diethylstilbestrol (DESAD Project).

Journal Article Am J Obstet Gynecol · June 1, 1983 A total of 452 women with documented exposure in utero to diethylstilbestrol (DES) with epithelial findings present at the time of their initial examination have been evaluated prospectively to determine whether these findings changed over a period of 3 ye ... Full text Link to item Cite

Nuclear DNA content of clear cell adenocarcinoma of the vagina and cervix and its relationship to prognosis.

Journal Article Gynecol Oncol · April 1983 A study was performed to determine if ploidy levels of nuclear DNA content could be used as a prognostic index of the biologic behavior of clear cell adenocarcinoma of the vagina and cervix in young females. Forty tumors were examined. Four patterns of nuc ... Full text Link to item Cite

Experimental study of the effect of diethylstilbestrol on the development of the human female reproductive tract.

Journal Article Biol Res Pregnancy Perinatol · 1983 Female genital tracts from human embryos and fetuses 5-17 weeks post fertilization were grown for 1-3 months in vivo as grafts to athymic female nude mice. The nude mice were either untreated or treated with diethylstilbestrol (DES). In control (untreated) ... Link to item Cite

Hepatoid yolk sac tumor of the ovary (endodermal sinus tumor with hepatoid differentiation): a light microscopic, ultrastructural and immunohistochemical study of seven cases.

Journal Article Cancer · December 1, 1982 Seven cases of ovarian yolk sac tumor (endodermal sinus tumor) with patterns resembling those of hepatocellular carcinoma were encountered in patients 7-43 years of age. Two of the patients had gonadal dysgenesis with a 46XY karyotype. At operation three t ... Full text Link to item Cite

Topographic relation of cervical ectropion and vaginal adenosis to clear cell adenocarcinoma.

Journal Article Obstet Gynecol · November 1982 Twenty specimens of uterus and vagina removed because of clear cell adenocarcinoma of the cervix or vagina in women exposed prenatally to diethylstilbestrol were serially blocked and sectioned to study the topographic relation between the carcinoma and the ... Link to item Cite

Autoradiographic analysis of nuclear estrogen binding sites during postnatal development of the genital tract of female mice.

Journal Article J Steroid Biochem · September 1982 Autoradiographic analysis of [3H]-estrogen nuclear binding sites was performed on developing genital tracts (uterus, cervix and vagina) of mice 1 to 90 days postpartum. During days 1 to 15 postpartum, nuclear estrogen binding sites were observed exclusivel ... Full text Link to item Cite

Dysgenesis of testicular and streak gonads in the syndrome of mixed gonadal dysgenesis: perspective derived from a clinicopathologic analysis of twenty-one cases.

Journal Article Hum Pathol · August 1982 The clinical and pathologic aspects of 21 cases of mixed gonadal dysgenesis (MGD) were studied. The gonads in 15 patients consisted of a macroscopic testis and a streak gonad; six patients had variants, including two with bilateral testes and four with bil ... Full text Link to item Cite

Normal development of the human female reproductive tract and alterations resulting from experimental exposure to diethylstilbestrol.

Journal Article Hum Pathol · March 1982 An in vivo model is described for the study of human uterovaginal development in the presence and absence of the teratogenic drug diethylstilbestrol (DES). Intact reproductive tracts from fragments of 29 human embryos and fetuses 5.0 to 17.7 weeks of age o ... Full text Link to item Cite

Detection bias in endometrial cancer.

Journal Article Lancet · January 16, 1982 Full text Link to item Cite

Neurohormonal peptides in ovarian carcinoids: an immunohistochemical study of 81 primary carcinoids and of intraovarian metastases from six mid-gut carcinoids.

Journal Article Cancer · January 1, 1982 Eighty-one primary ovarian carcinoids and intraovarian metastases from six mid-gut carcinoids were examined for the presence of tumor cells immunoreactive with antisera raised against various neurohormonal peptides, mostly of gastroenteropancreatic (GEP) o ... Full text Link to item Cite

Epidermoid hidradenoma. A clinicopathologic study

Journal Article Journal of Cutaneous Pathology · 1982 Clinical and histopathologic data in 8 cases of epidermoid hidradenoma are presented. Most of the tumors were in the head and neck, and most of the patients were middle-aged and older adults. Generally, the lesions were asymptomatic nodules that sometimes ... Full text Cite

ESTROGEN-DEPENDENT LESIONS

Journal Article International Journal of Gynecological Pathology · 1982 Full text Cite

PRIMARY OVARIAN INVOLVEMENT BY LYMPHOMA OR LEUKEMIA

Journal Article LABORATORY INVESTIGATION · January 1, 1982 Link to item Cite

Hypothesis: when is a seminoma not a seminoma?

Journal Article J Clin Pathol · November 1981 Full text Link to item Cite

Histopathologic distinctions in the relationship of estrogens and endometrial cancer.

Journal Article JAMA · September 25, 1981 The slides of 233 patients included in a case-control study of estrogens and endometrial cancer were reviewed to determine how often endometrial cancer was misdiagnosed and whether patients with uterine cancer had other coexistent endometrial diseases. Rea ... Link to item Cite

Breast carcinoma masquerading as primary ovarian neoplasm.

Journal Article Cancer · July 1, 1981 Metastases which present as palpable masses in the pelvis occasionally masquerade as primary neoplasms of the ovary. Although most such cancers originate in the stomach and large intestine, the histories of two patients are presented in whom the ovarian tu ... Full text Link to item Cite

Dysplasia and cytologic findings in 4,589 young women enrolled in diethylstilbestrol-adenosis (DESAD) project.

Journal Article Am J Obstet Gynecol · July 1, 1981 This report presents the cytologic findings and the rates of dysplasia for 4,589 young women enrolled in the National Cooperative Diethylstilbestrol-Adenosis (DESAD) Project. Mucinous columnar cells and/or metaplastic squamous cells with or without mucinou ... Full text Link to item Cite

Retrieval in a Computer-assisted Pathology Encoding and Reporting System (CAPER).

Journal Article Am J Clin Pathol · May 1981 A previous report described an online computer-assisted pathology encoding and reporting system (CAPER) developed at the Massachusetts General Hospital that accessions specimens, monitors their state of completion, produces all log books, and permits insta ... Full text Link to item Cite

YOLK-SAC TUMOR OF OVARY WITH HEPATOID DIFFERENTIATION

Journal Article LABORATORY INVESTIGATION · January 1, 1981 Link to item Cite

Strumal carcinoid of the ovary: an analysis of 50 cases of a distinctive tumor composed of thyroid tissue and carcinoid.

Journal Article Cancer · November 1, 1980 Strumal carcinoid of the ovary is a type of germ-cell tumor characterized by an intimate mixture of thyroid tissue and carcinoid. Fifty patients with this type of tumor ranged in age from 21 to 77 years. The tumors measured up to 26 cm in diameter and were ... Full text Link to item Cite

Risk factors for cancer of the testis.

Journal Article N Engl J Med · July 10, 1980 Full text Link to item Cite

Case 23-1980: A 34-Year-Old Woman with Pelvic Pain Not Relieved by Hysterectomy and Salpingo-Oophorectomy for Endometriosis

Journal Article New England Journal of Medicine · June 12, 1980 Presentation of Case A 34-year-old nulliparous woman was admitted to the hospital because of right-sided pelvic pain. Twelve years before admission the patient experienced right-sided pelvic pain during ovulation and menstruation; a physician palpated a ri ... Full text Cite

Endodermal sinus tumor of the pineal region.

Journal Article Cancer · May 15, 1980 Two cases of endodermal sinus tumor of the pineal region are reported and compared with 16 others in the literature. The preponderance of neoplasms occurs in boys, usually in their second decade. The diagnosis is usually established within three months of ... Full text Link to item Cite

Ultrastructure of 16 cases of clear cell adenocarcinoma of the vagina and cervix in young women.

Journal Article Cancer · April 1, 1980 Sixteen cases of clear cell adenocarcinoma of the cervix and vagina in young women were studied by electron microscopy and the observations were compared with the light microscopic appearance. Ultrastructurally, the neoplastic cells were found to be of the ... Full text Link to item Cite

Case 10-1980: A 29-Year-Old Woman with Amenorrhea and Hirsutism

Journal Article New England Journal of Medicine · March 13, 1980 Presentation of Case A 29-year-old woman was admitted to the hospital because of hirsutism and amenorrhea. Menarche occurred at the age of 12 years, with regular menses preceded by one day of mild cramps; she frequently experienced mittelschmerz. At the ag ... Full text Cite

Neurohormonal peptides in primary ovarian carcinoids. An immunohistochemical study

Journal Article Acta Obstetricia et Gynecologica Scandinavica · January 1, 1980 Although the primary ovarian carcinoid does not give rise to symptoms characteristic of an endocrine tumor (except the one-third with the classical carcinoid syndrome), they still have the capacity to produce one or several peptide hormones. The spectrum o ... Cite

29-YEAR-OLD WOMAN WITH AMENORRHEA AND HIRSUTISM - THECOMA OF OVARY, WITH VIRILIZATION

Journal Article NEW ENGLAND JOURNAL OF MEDICINE · January 1, 1980 Link to item Cite

Torulopsis glabrata fungemia--a clinical pathological study.

Journal Article Medicine (Baltimore) · November 1979 The clinical findings, pathologic features, and outcome were investigated in 46 patients in whom Torulopsis glabrata was isolated in 131 specimens of blood. Nineteen of the patients had only a single positive blood culture and no evidence of systemic yeast ... Full text Link to item Cite

Changing trends and prognostic features in endometrial cancer associated with exogenous estrogen therapy.

Journal Article Obstet Gynecol · September 1979 A study was undertaken to investigate changing trends in the microscopic patterns of endometrial carcinoma and to compare the biologic characteristics of those cases associated with and without estrogen usage. After each case was reviewed independently and ... Link to item Cite

Prenatal diethylstilbestrol exposure and human genital tract abnormalities.

Journal Article Natl Cancer Inst Monogr · May 1979 The incidence of clear cell adenocarcinoma of the vagina and cervix associated with intrauterine exposure to DES and similar compounds during the first half of pregnancy has increased. Ninety percent of these cancers have occurred in patients 14 years of a ... Link to item Cite

Vaginal epithelial changes in young women enrolled in the National Cooperative Diethylstilbestrol Adenosis (DESAD) project.

Journal Article Obstet Gynecol · March 1979 Initial clinical findings are reported for the 3339 young women enrolled in the Diethylstilbestrol Adenosis (DESAD) project. Changes in the vaginal mucosa (VEC--vaginal epithelial changes), which were detected by colposcopy or iodine staining, occurred in ... Link to item Cite

Comparison of histologic and colposcopic findings in des-exposed females

Journal Article Obstetrical and Gynecological Survey · January 1, 1979 Full text Cite

Complications of prenatal therapy with diethylstilbestrol

Journal Article Pediatrics · December 1, 1978 The possibility that adenosis of the vagina is a premalignant lesion was discussed. Vaginal adenosis had been recorded prior to the availability of diethylstilbestrol. Transverse vaginal ridges, which occur as a consequence of prenatal diethylstilbestrol e ... Cite

Comparison of histologic and colposcopic findings in DES-exposed females.

Journal Article Obstet Gynecol · October 1978 A study was undertaken to evaluate the histologic alterations associated with two of the most abnormal colposcopic findings, mosaicism and punctation, that are commonly found in the vaginas and cervices of young women who have been exposed prenatally to di ... Link to item Cite

Squamous cell dysplasia and carcinoma in situ of the cervix and vagina after prenatal exposure to diethylstilbestrol.

Journal Article Obstet Gynecol · May 1978 Squamous cell abnormalities of the vagina and cervix were evaluated in 1424 women exposed to diethylstilbestrol (DES) in utero. The prevalence of dysplasia was 2.1% and the incidence 0.85/100 person-years of followup. The dysplastic epithelial changes were ... Full text Link to item Cite

Immediate pathologic confirmation of radiologic interpretations by computer feedback.

Journal Article Radiology · May 1978 A computer system is used to provide automatic pathology diagnostic feedback to radiologists. This feedback occurs on a daily basis whenever surgical specimens are obtained for which pertinent radiologic examinations have been performed. On-line inquiry ca ... Full text Link to item Cite

Case 13-1978: Disseminated Intravascular Coagulation, Pleural Effusions and Ascites in a 53-Year-Old Woman

Journal Article New England Journal of Medicine · April 6, 1978 Presentation of Case First admission. A 53-year-old woman was admitted to the hospital because of disseminated intravascular coagulation. She was well until one month earlier, when she entered another hospital because of deep thrombophlebitis of the left l ... Full text Cite

Design and preliminary observations of National Cooperative Diethylstilbestrol Adenosis (DESAD) Project.

Journal Article Obstet Gynecol · April 1978 The National Cooperative Diethylstilbestrol Adenosis (DESAD) Project has completed the major portion of its enrollment phase with the examination of more than 3000 daughters of women taking synthetic nonsteroidal estrogens (denoted DES) during pregnancies ... Full text Link to item Cite

Urogenital sinus origin of mucinous and ciliated cysts of the vulva.

Journal Article Obstet Gynecol · March 1978 The origin of mucinous and ciliated cells in the vulva and the pathogenesis of cysts lined by these epithelia were investigated. Small mucinous glands numbering from one to more than a hundred were encountered in 9 of 19 vulvas (53%) that were consecutivel ... Full text Link to item Cite

Blue nevus of the cervix.

Journal Article Tumori · February 28, 1978 Full text Link to item Cite

Computer-assisted pathology encoding and reporting system (CAPER).

Journal Article Am J Clin Pathol · December 1977 An on-line computer-assisted pathology encoding and reportying system (CAPER) has been developed by the Department of Pathology and Laboratory of Computer Science of the Massachusetts General Hospital for a department of surgical pathology that processes m ... Full text Link to item Cite

Age-incidence and risk of diethylstilbestrol-related clear cell adenocarcinoma of the vagina and cervix.

Journal Article Am J Obstet Gynecol · May 1, 1977 This study was based on cases accessioned in the Registry of Clear Cell Adenocarcinoma of the Genital Tract in Young Females to ascertain the incidence of diethylstilbestrol (DES)-related cancers by age and year of birth. For accuracy in estimating the siz ... Full text Link to item Cite

Microglandular hyperplasia in vaginal adenosis associated with oral contraceptives and prenatal diethylstilbestrol exposure.

Journal Article Obstet Gynecol · April 1977 Eight cases of microglandular hyperplasia arising in vaginal adenosis are presented. Five of the patients were known to have taken oral contraceptives and a sixth was pregnant at the time the lesion was discovered; a history of prenatal exposure to diethyl ... Link to item Cite

Case 8-1977: Pelvic Mass in a 53-Year-Old Woman with Primary Amenorrhea

Journal Article New England Journal of Medicine · February 24, 1977 Presentation of Case A 53-year-old woman was admitted to the hospital because of a pelvic mass. She was well until 10 days previously, when she became constipated and felt lower abdominal “pressure,” accompanied by dribbling incontinence of urine. One week ... Full text Cite

Primary trabecular carcinoid of the ovary.

Journal Article Obstet Gynecol · February 1977 Eighteen cases of primary trabecular carcinoid of the ovary were analyzed from a clinicopathologic viewpoint. The patients ranged in age from 24 to 74 years and presented with symptoms of an ovarian mass; none had the carcinoid syndrome. Although the carci ... Link to item Cite

Primary trabecular carcinoid of the ovary

Journal Article Obstetrical and Gynecological Survey · January 1, 1977 Full text Cite

Intrauterine diethylstilbestrol exposure and its consequences: pathologic characteristics of vaginal adenosis, clear cell adenocarcinoma, and related lesions.

Journal Article Arch Pathol Lab Med · January 1977 In 1971, the development of clear cell adenocarcinoma of the vagina in young females was first linked to a history of intrauterine exposure to diethylstilbestrol (DES). This communication reviews data on cases accessioned in the Registry of Clear Cell Aden ... Link to item Cite

Aspergillus-induced small bowel obstruction in a leukemic newborn.

Journal Article Surgery · January 1977 An infant with congenital acute myelocytic leukemia, who was being treated with chemotherapeutic agents, developed obstruction and infarction of the ileum due to occlusion of mesenteric arteries by Aspergillus hyphae. This case demonstrates how blood vesse ... Link to item Cite

Introduction

Journal Article Human Pathology · January 1, 1977 Full text Cite

Primary trabecular carcinoid of the ovary

Journal Article Obstet Gynecol · 1977 Cite

The embryologic development of the human vagina.

Journal Article Am J Obstet Gynecol · December 1, 1976 Our present understanding of the sequence and mechanisms of human genital organogenesis is reviewed. Current theories about the derivation of the vaginal epithelium are examined and tested against two anomalous circumstances, congenital androgen insensitiv ... Full text Link to item Cite

Cytology of 575 young women with prenatal exposure to diethylstilbestrol.

Journal Article Obstet Gynecol · November 1976 The vaginal and cervical cellular changes encountered in 575 postpubertal females exposed prenatally to diethylstilbestrol (DES) were compared with those of an unexposed population with particular reference to the role of cytology in the detection of vagin ... Link to item Cite

Case 44-1976: Recurrent Venous Thrombosis and Hepatic Enlargement

Journal Article New England Journal of Medicine · October 28, 1976 Presentation of Case A 66-year-old woman was admitted to the hospital because of mental deterioration. She was described as “emotionally unstable” but was physically well until seven months previously, when she began to have episodic belching with bouts of ... Full text Cite

Case 39-1976: Fever, Cardiac Arrhythmias and Pericarditis after Aortic-Valve Replacement

Journal Article New England Journal of Medicine · September 23, 1976 Presentation of Case A 54-year-old man was admitted to the hospital because of aortic stenosis. He was well until two years previously, when glycosuria was found. Tolbutamide was administered briefly; he lost 24 kg on a weight-reduction diet, and the medic ... Full text Cite

Case 37-1976: Intestinal Obstruction in an Infant with Congenital Leukemia

Journal Article New England Journal of Medicine · September 9, 1976 Presentation of Case A four-day-old girl was admitted to the hospital because of leukemia. She was born at 38 weeks' gestation of the third pregnancy of a healthy mother aged 28 years. The pregnancy was complicated at six weeks by an untreated nonspecific ... Full text Cite

Case 26-1976: Spinal-Cord Disorder in a Woman with Carcinoma

Journal Article New England Journal of Medicine · June 24, 1976 Presentation of Case A 64-year-old woman was admitted to the hospital because of inability to walk. She was well until three weeks previously, when she experienced a “pulling” sensation in the right groin that persisted and was accompanied by urinary frequ ... Full text Cite

Glassy cell carcinoma of the cervix.

Journal Article Cancer · May 1976 A clinicopathologic analysis of 13 cases of glassy cell carcinoma of the uterine cervix is presented. The glassy cell carcinoma is considered to be a poorly differentiated mixed adenosquamous carcinoma. Its histologic appearance is distinctive, being chara ... Full text Link to item Cite

Nuclear chromatin determination in amniotic fluid cells for prenatal sex prediction in the macaque.

Journal Article Am J Obstet Gynecol · April 1, 1976 Amniotic fluid cells obtained after the ninetieth day of gestation in the macaque were analyzed for nuclear chromatin. The technique proved reliable for the prediction of fetal sex. ... Full text Link to item Cite

SPINAL-CORD DISORDER IN A WOMAN WITH CARCINOMA

Journal Article NEW ENGLAND JOURNAL OF MEDICINE · January 1, 1976 Link to item Cite

Cushing syndrome, sexual precocity, and polyostotic fibrous dysplasia (Albright syndrome) in infancy.

Journal Article J Pediatr · December 1975 The sexual precocity of polyostotic fibrous dysplasia is occasionally accompanied by other endocrine disorders, but in only two previous instances has Cushing syndrome been reported. The history of a 6-month-old girl is presented, in whom this syndrome was ... Full text Link to item Cite

Pathogenesis of fungal infection on heart valve prosthesis.

Journal Article Hum Pathol · November 1975 Four patients with heart valve prostheses developed Candidate endocarditis. At autopsy the foci of infection were confined to patches of neoendocardium that appeared to have developed as ingrowths of host endocardium onto the sewing cloth of the artificial ... Full text Link to item Cite

Insular carcinoid primary in the ovary. A clinicopathologic analysis of 48 cases.

Journal Article Cancer · August 1975 Forty-eight cases of primary insular carcinoid of the ovary were analyzed from a clinicopathologic viewpoint. Sixteen (33%) were associated with preoperative clinical evidence of the carcinoid syndrome. At operation only one ovary was usually enlarged, but ... Full text Link to item Cite

Ultrastructure of primary and metastatic ovarian carcinoids: analysis of 11 cases.

Journal Article Cancer · July 1975 The ultrastructure of 11 ovarian carcinoids was investigated. The 6 carcinoids with an insular pattern primary in the ovary or metastatic to it from the ileum displayed granules that were pleomorphic (dumbbell and reniform shaped) and varied from 90 to 410 ... Full text Link to item Cite

Case 4-1975: Sexual Precocity with Polyostotic Fibrous Dysplasia

Journal Article New England Journal of Medicine · January 23, 1975 Presentation of Case First admission. A two-and-a-half-year-old girl was admitted to the hospital because of sexual precocity. She was born at 42 weeks of gestation, with a birth weight of 2.4 kg. Café-au-lait spots were noted at birth. Vaginal spotting of ... Full text Cite

Carcinoid metastatic to the ovary. A clinicopathologic analysis of 35 cases

Journal Article Obstetrical and Gynecological Survey · January 1, 1975 Full text Cite

Effects of maternal DES ingestion on the female genital tract

Journal Article Hospital Practice · January 1, 1975 More than 250 cases of vaginal or cervical carcinoma among young females (age 7 to 29 yr) have been entered in a registry established after the association between these rare cancers and maternal stilbestrol ingestion became apparent. The number may increa ... Full text Cite

Problems in the examination of the des-exposed female

Journal Article Obstetrics and Gynecology · January 1, 1975 Cite

Clinical and epidemiological characteristics of young females developing cancer after intrauterine exposure to diethylstilbestrol and related drugs

Journal Article EXCERPTA MEDICA, ICS NO. 350 · 1975 A case control epidemiologic investigation associated the occurrence of 7 of 8 cases of clear cell adenocarcinoma of the vagina and cervix with maternal ingestion of diethylstilbestrol (DES) administered for the treatment of high risk pregnancy. ... Cite

MASS IN REGION OF 3RD VENTRICLE IN AN 8-YEAR-OLD GIRL

Journal Article NEW ENGLAND JOURNAL OF MEDICINE · January 1, 1975 Link to item Cite

Clinical and epidemiological characteristics of young females developing cancer after intrauterine exposure to diethylstilbestrol and related drugs

Journal Article EXCERPTA MEDICA, ICS NO. 350 · January 1, 1975 A case control epidemiologic investigation associated the occurrence of 7 of 8 cases of clear cell adenocarcinoma of the vagina and cervix with maternal ingestion of diethylstilbestrol (DES) administered for the treatment of high risk pregnancy. ... Cite

Case 50-1974: Diarrhea and Thoracoabdominal Mass in a Year-Old Girl

Journal Article New England Journal of Medicine · December 19, 1974 Presentation of Case A 12-month-old girl was admitted to the hospital because of a thoracoabdominal mass. She was born of a normal pregnancy, labor and delivery and was well until three months before admission, when she began to have diarrhea after each fe ... Full text Cite

Case 48-1974: Recurrent Thrombophlebitis in a 56-Year-Old Man

Journal Article New England Journal of Medicine · December 5, 1974 Presentation of Case A 56-year-old man was admitted to the hospital because of pain in the left calf. He was well until five weeks previously, when he noticed pain and swelling in the right calf and came to the hospital. Examination disclosed enlargement o ... Full text Cite

Case 44-1974: Candida Septicemia after Double Valve Replacements

Journal Article New England Journal of Medicine · November 7, 1974 Presentation of Case A 46-year-old woman was admitted to the hospital because of rheumatic heart disease. Between six and 18 years of age she had 18 episodes of rheumatic fever. At the age of 32 years digitoxin therapy was begun because of atrial fibrillat ... Full text Cite

Case 41-1974: Spinal-Cord Compression Associated with a Tumor in the Pineal Region

Journal Article New England Journal of Medicine · October 17, 1974 Presentation of Case First admission. A 12-year-old girl was admitted to the hospital because of meningitis. Growth had ceased at the age of nine years, and no secondary sex characteristics had developed. During the six months before admission she experien ... Full text Cite

Clear-cell adenocarcinoma of the vagina and cervix in girls: Analysis of 170 Registry cases

Journal Article American Journal of Obstetrics and Gynecology · July 1, 1974 One hundred cases of vaginal and 70 cervical adenocarcinomas from the Registry of Clear-Cell Adenocarcinoma of the Genital Tract in Young Females have been analyzed. The age range of the patients was 7 to 29 years, and the frequent association with prenata ... Full text Cite

Letter: Treatment of dysgerminoma.

Journal Article N Engl J Med · April 4, 1974 Full text Link to item Cite

Case 1-1974: Abdominal Mass 18 Months after Removal of an Ovarian Dysgerminoma

Journal Article New England Journal of Medicine · January 10, 1974 Presentation of Case A 26-year-old married woman, gravida 1, para 0, was admitted to the hospital because of persistent flank pain. Eighteen months before admission she entered another hospital because of pain in the right lower quadrant of the abdomen. Th ... Full text Cite

The effects of local progesterone on stilbestrol-associated vaginal adenosis

Journal Article Obstetrical and Gynecological Survey · January 1, 1974 Full text Cite

Vaginal and cervical abnormalities, including clear-cell adenocarcinoma, related to prenatal exposure to stilbestrol.

Journal Article Ann Clin Lab Sci · 1974 A variety of vaginal and cervical abnormalities have been encountered in the offspring of women who have taken stilbestrol or chemically related nonsteroidal estrogens during pregnancy. Cervical erosion has been noted most often, but vaginal adenosis has b ... Link to item Cite

Case 26-1973: Fever and Rash in a Girl with Juvenile Rheumatoid Arthritis

Journal Article New England Journal of Medicine · June 28, 1973 Presentation of Case An 11-year-old girl was admitted to the hospital because of fever and a rash. She was well until 15 months previously, when anorexia occurred, with a daily rise of the temperature as high as 39.4°C, a generalized erythematous rash and ... Full text Cite

Case 21-1973: Cavitary Lung Lesion in a Man with Reticulum-Cell Sarcoma on Immunosuppressive Therapy

Journal Article New England Journal of Medicine · May 24, 1973 Presentation of Case A 71-year-old man was admitted to the hospital because of fever. He was well until three months previously, when anorexia developed, with epigastric pain and loss of 14 kg in weight. On admission to another hospital an abdominal mass w ... Full text Cite

Intranuclear inclusion bodies.

Journal Article N Engl J Med · April 26, 1973 Full text Link to item Cite

Case 7-1973: Thrombocytopenia in a Newborn Girl

Journal Article New England Journal of Medicine · February 15, 1973 Presentation of Case A newborn girl, aged eight hours, was admitted to the hospital because of petechiae. The child was the product of a 39-week gestation in a gravida 2, 23-year-old mother. The pregnancy was complicated by a febrile illness without a rash ... Full text Cite

Case 1-1973: Mass Involving Small Intestine with Striking Angiographic Findings

Journal Article New England Journal of Medicine · January 4, 1973 Presentation of Case A 67-year-old man was admitted to the hospital because of abdominal pain. He had been in excellent health until three months before admission, when there was the gradual onset of intermittent crampy periumbilical pain that was accompan ... Full text Cite

A new stain for systemic fungi in tissue.

Journal Article Am J Clin Pathol · January 1972 Full text Link to item Cite

Measurement of fibrinogen degradation products.

Journal Article N Engl J Med · December 24, 1970 Full text Link to item Cite

Case 44-1970: Hepatic Coma with Pulmonary Infiltrates in a 15-Year-Old Girl

Journal Article New England Journal of Medicine · October 22, 1970 Presentation of Case A 15-year-old girl was admitted to the hospital because of hepatitis. Ten months previously her ears had been pierced by a physician. At about that time a classmate contracted hepatitis. One month later jaundice developed insidiously, ... Full text Cite