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Andrew Joseph Muir

Professor of Medicine
Medicine, Gastroenterology
Duke Box 3913, Durham, NC 27710
03137B Hosp South, Durham, NC 27710

Selected Publications


Barriers and Strategies to Effective Serious Illness Communication for Patients with End-Stage Liver Disease in the Intensive Care Setting.

Journal Article J Intensive Care Med · September 9, 2024 Background: Patients with end-stage liver disease (ESLD) often require Intensive Care Unit (ICU) admission during the disease trajectory, but aggressive medical treatment has not resulted in increased quality of life for patients or caregivers. Methods: Th ... Full text Link to item Cite

Inadequate Dietary Education and Poor Adherence to a High Protein, Low Sodium Diet in Cirrhosis: Mixed Methods Approach.

Journal Article Dig Dis Sci · September 2024 BACKGROUND: Malnutrition in cirrhosis is associated with poor outcomes, leading to guidelines for a high protein, low sodium diet; however, there is no guidance regarding the implementation of diet education in clinical practice. METHODS: A mixed methods s ... Full text Link to item Cite

Psychological processes and alcohol reduction in patients with chronic hepatitis C: Results from the HepART trial.

Journal Article Alcohol Clin Exp Res (Hoboken) · August 2024 BACKGROUND: There is a lack of randomized controlled trials of behavioral interventions and process-level research related to alcohol reduction among patients with chronic liver disease (e.g., hepatitis C viral (HCV) infection). We conducted a process-leve ... Full text Link to item Cite

Decreased Completion of Ordered Laboratories and Imaging in Telehealth Compared With In-person Hepatology Encounters.

Journal Article J Clin Gastroenterol · July 16, 2024 OBJECTIVE: To evaluate order completion after telehealth compared with in-person encounters. BACKGROUND: Completion of ordered testing, including laboratories and imaging, is an important aspect of successful outpatient care of patients with liver disease. ... Full text Link to item Cite

Serologic extracellular matrix remodeling markers are related to fibrosis stage and prognosis in a phase 2b trial of simtuzumab in patients with primary sclerosing cholangitis.

Journal Article Hepatol Commun · July 1, 2024 BACKGROUND: Novel noninvasive predictors of disease severity and prognosis in primary sclerosing cholangitis (PSC) are needed. This study evaluated the ability of extracellular matrix remodeling markers to diagnose fibrosis stage and predict PSC-related fi ... Full text Link to item Cite

Outcomes of early vs late treatment initiation in solid organ transplantation from hepatitis C virus nucleic acid test-positive donors to hepatitis C virus-uninfected recipients: Results from the HCV-TARGET study.

Journal Article Am J Transplant · March 2024 Curative hepatitis C virus (HCV) therapy has increased transplantation from HCV-infected nucleic acid test-positive donors to HCV-uninfected recipients (D+/R-). We evaluated outcomes of early and late HCV treatment among D+/R- nonliver organ transplants. P ... Full text Link to item Cite

Characterization of social determinants of health of a liver transplant referral population.

Journal Article Liver Transpl · November 1, 2023 Disparities exist in referral and access to the liver transplant (LT) waitlist, and social determinants of health (SDOH) are increasingly recognized as important factors driving health inequities, including in LT. The SDOH of potential transplant candidate ... Full text Link to item Cite

Parental leave, childcare policies, and workplace bias for hepatology professionals: A national survey.

Journal Article Hepatol Commun · September 1, 2023 BACKGROUND: The presence of workplace bias around child-rearing and inadequate parental leave may negatively impact childbearing decisions and sex equity in hepatology. This study aimed to understand the influence of parental leave and child-rearing on car ... Full text Link to item Cite

Safety and Sustained Efficacy of the Farnesoid X Receptor (FXR) Agonist Cilofexor Over a 96-Week Open-label Extension in Patients With PSC.

Journal Article Clin Gastroenterol Hepatol · June 2023 BACKGROUND & AIMS: Primary sclerosing cholangitis (PSC) is a major unmet medical need in clinical hepatology. Cilofexor is a nonsteroidal farnesoid X receptor agonist being evaluated for the treatment of PSC. Here, we describe the safety and preliminary ef ... Full text Link to item Cite

Immunostaining for hepatitis B viral antigens in liver: Association with clinical, biochemical, and virologic features of disease.

Journal Article J Gastroenterol Hepatol · June 2023 BACKGROUND AND AIM: Staining for hepatitis B viral antigens is often done in liver biopsies from patients with chronic hepatitis B, but its correlates with clinical phenotypes are not well described. METHODS: Biopsies were collected from a large cohort of ... Full text Link to item Cite

Safety and yield of percutaneous liver biopsy in adults and children with chronic hepatitis B: Results from a prospective, multicenter study.

Journal Article Hepatol Commun · June 1, 2023 BACKGROUND: Prospective data regarding the safety and yield of liver biopsy in both adults and children with chronic hepatitis B are limited. The aim of this study is to report safety, yield, and complication rates among adults and children with chronic he ... Full text Link to item Cite

Consider hospice in end-stage liver disease prognostic scale to open discussions regarding six-month mortality.

Journal Article JGH Open · April 2023 BACKGROUND AND AIM: Hospice is underutilized in the management of patients with end-stage liver disease and may improve the patient experience at the end of life. This study aims to create a novel prognostic scale to accurately predict 6-month mortality to ... Full text Link to item Cite

Liver stiffness thresholds to predict disease progression and clinical outcomes in bridging fibrosis and cirrhosis.

Journal Article Gut · March 2023 OBJECTIVE: In retrospective studies, liver stiffness (LS) by vibration-controlled transient elastography (VCTE) is associated with the risk of liver decompensation in patients with non-alcoholic steatohepatitis (NASH), but prospective data in biopsy-confir ... Full text Link to item Cite

Performance of the Pooled Cohort Equations in non-alcoholic fatty liver disease: The Multi-Ethnic Study of Atherosclerosis.

Journal Article Liver Int · March 2023 BACKGROUND AND AIMS: Non-alcoholic fatty liver disease (NAFLD) is associated with a high risk of cardiovascular disease. Whether risk scores developed in the general population accurately assess cardiovascular risk in the NAFLD population is unknown. This ... Full text Link to item Cite

Rates of employment after liver transplant: A nationwide cohort study.

Journal Article Hepatology communications · March 2023 BackgroundEmployment outcomes after liver transplant (LT) over the past decade have not been described.MethodsLT recipients ages 18-65 from 2010-2018 were identified in Organ Procurement and Transplantation Network data. Employment within ... Full text Cite

Evaluation of an Abnormal Liver Panel After Liver Transplantation.

Journal Article Clin Liver Dis · February 2023 Abnormal liver tests are common after liver transplantation. The differential diagnosis depends on the clinical context, particularly the time course, pattern and degree of elevation, and donor and recipient factors. The perioperative period has distinct c ... Full text Link to item Cite

Access to technology to support telehealth in areas without specialty care for liver disease.

Journal Article Hepatology · January 1, 2023 BACKGROUND AND AIMS: Telehealth may be a successful strategy to increase access to specialty care for liver disease, but whether the areas with low access to care and a high burden of liver-related mortality have the necessary technology access to support ... Full text Link to item Cite

Patient-Predicted Outcomes Are Associated with Quality of Life in Patients with Primary Sclerosing Cholangitis.

Journal Article Dig Dis Sci · December 2022 BACKGROUND: Primary sclerosing cholangitis (PSC) is a chronic, progressive liver disease, and many patients ultimately require liver transplantation (LT). PSC also confers an increased risk of malignancies, including cholangiocarcinoma (CCA) and colorectal ... Full text Link to item Cite

MELD-Na Accurately Predicts 6-Month Mortality in Patients With Decompensated Cirrhosis: Potential Trigger for Hospice Referral.

Journal Article J Clin Gastroenterol · November 2022 GOAL: The goal of this study was to determine the accuracy of Model of End-stage Liver Disease-Sodium (MELD-Na) in predicting 6-month mortality for patients listed for liver transplantation on the United Network of Organ Sharing (UNOS) waitlist. BACKGROUND ... Full text Link to item Cite