Scholars@Duke
Patricia Gripka Moorman

Patricia Gripka Moorman

Professor Emeritus in Family Medicine and Community Health
Family Medicine and Community Health, Prevention Research
patricia.moorman@duke.edu
Box 2715 Med Ctr, Durham, NC 27710
2424 Erwin Road, Suite 602, Durham, NC 27705

Selected Publications

Menopausal hormone therapy use and risk of ovarian cancer by race: the ovarian cancer in women of African ancestry consortium.

Journal Article Br J Cancer · December 2023 BACKGROUND: Most studies examining post-menopausal menopausal hormone therapy (MHT) use and ovarian cancer risk have focused on White women and few have included Black women. METHODS: We evaluated MHT use and ovarian cancer risk in Black (n = 800 cases, 17 ... Full text Link to item Cite

Racial Differences in the Association of Endometriosis and Uterine Leiomyomas With the Risk of Ovarian Cancer.

Conference Obstet Gynecol · June 1, 2023 OBJECTIVE: To evaluate associations between endometriosis and uterine leiomyomas with ovarian cancer risk by race and the effect of hysterectomy on these associations. METHODS: We used data from four case-control studies and two case-control studies nested ... Full text Link to item Cite

Survival of epithelial ovarian cancer in Black women: a society to cell approach in the African American cancer epidemiology study (AACES).

Journal Article Cancer causes & control : CCC · March 2023 PurposeThe causes for the survival disparity among Black women with epithelial ovarian cancer (EOC) are likely multi-factorial. Here we describe the African American Cancer Epidemiology Study (AACES), the largest cohort of Black women with EOC. Full text Cite

Racial differences in the association of body mass index and ovarian cancer risk in the OCWAA Consortium.

Journal Article Br J Cancer · November 2022 BACKGROUND: Obesity disproportionately affects African American (AA) women and has been shown to increase ovarian cancer risk, with some suggestions that the association may differ by race. METHODS: We evaluated body mass index (BMI) and invasive epithelia ... Full text Link to item Cite

Racial disparities in epithelial ovarian cancer survival: An examination of contributing factors in the Ovarian Cancer in Women of African Ancestry consortium.

Conference Int J Cancer · October 15, 2022 Black women diagnosed with epithelial ovarian cancer have poorer survival compared to white women. Factors that contribute to this disparity, aside from socioeconomic status and guideline-adherent treatment, have not yet been clearly identified. We examine ... Full text Link to item Cite

Race Differences in the Associations between Menstrual Cycle Characteristics and Epithelial Ovarian Cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · August 2, 2022 BACKGROUND: Menstrual cycle characteristics-including age at menarche and cycle length- have been associated with ovarian cancer risk in White women. However, the associations between menstrual cycle characteristics and ovarian cancer risk among Black wome ... Full text Link to item Cite

Racial Differences in the Tumor Immune Landscape and Survival of Women with High-Grade Serous Ovarian Carcinoma.

Journal Article Cancer Epidemiol Biomarkers Prev · May 4, 2022 BACKGROUND: Tumor-infiltrating lymphocytes (TIL) confer a survival benefit among patients with ovarian cancer; however, little work has been conducted in racially diverse cohorts. METHODS: The current study investigated racial differences in the tumor immu ... Full text Link to item Cite

Psychosocial factors associated with genetic testing status among African American women with ovarian cancer: Results from the African American Cancer Epidemiology Study.

Journal Article Cancer · March 15, 2022 BACKGROUND: Racial disparities in the uptake of cancer genetic services are well documented among African American (AA) women. Understanding the multiple social and psychological factors that can influence the uptake of genetic testing among AA women is ne ... Full text Link to item Cite

Abstract PO-232: Racial differences in the tumor immune landscape and survival of high-grade serous ovarian carcinoma

Conference Cancer Epidemiology, Biomarkers & Prevention · January 1, 2022 AbstractA survival benefit has been consistently observed for tumor infiltrating lymphocytes (TILs) among ovarian cancer patients; however, prior studies consist of predominantly white women and little work ... Full text Cite

Genital Powder Use and Risk of Epithelial Ovarian Cancer in the Ovarian Cancer in Women of African Ancestry Consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · September 2021 BACKGROUND: Genital powder use is more common among African-American women; however, studies of genital powder use and ovarian cancer risk have been conducted predominantly in White populations, and histotype-specific analyses among African-American popula ... Full text Link to item Cite

First- and second-degree family history of ovarian and breast cancer in relation to risk of invasive ovarian cancer in African American and white women.

Journal Article Int J Cancer · June 15, 2021 Family history (FH) of ovarian cancer and breast cancer are well-established risk factors for ovarian cancer, but few studies have examined this association in African American (AA) and white women by histotype. We assessed first- and second-degree FH of o ... Full text Link to item Cite

Racial Differences in Population Attributable Risk for Epithelial Ovarian Cancer in the OCWAA Consortium.

Journal Article J Natl Cancer Inst · June 1, 2021 BACKGROUND: The causes of racial disparities in epithelial ovarian cancer (EOC) incidence remain unclear. Differences in the prevalence of ovarian cancer risk factors may explain disparities in EOC incidence among African American (AA) and White women. MET ... Full text Link to item Cite

Implications of Regionalizing Care in the Developing World: Impact of Distance to Referral Center on Compliance to Biopsy Recommendations in a Brazilian Prostate Cancer Screening Cohort.

Journal Article Prostate Cancer · 2021 Given growing specialization in medical care, optimal care may require regionalization, which may create access barriers. We tested this within a large prostate cancer (PC) screening program in Brazil. In 2004-2007, Barretos Cancer Hospital prospectively s ... Full text Link to item Cite

Menopausal hormone therapy use and long-term all-cause and cause-specific mortality in the Long Island Breast Cancer Study Project.

Journal Article Int J Cancer · December 15, 2020 Previous studies have observed a reduced mortality risk associated with menopausal hormone therapy (MHT) use among breast cancer survivors. We sought to clarify whether such association could be explained by tumor heterogeneity, specific causes of death, c ... Full text Link to item Cite

Associations between genetic variants of KIF5B, FMN1, and MGAT3 in the cadherin pathway and pancreatic cancer risk.

Journal Article Cancer Med · December 2020 Because the cadherin-mediated signaling pathway promotes cancer progression, we assessed associations between genetic variants in 109 cadherin-related genes and risk of pancreatic cancer (PanC) by using genotyping data from publically available genome-wide ... Full text Open Access Link to item Cite

Abstract 1180: Estimating the contribution of epidemiologic risk factors to racial differences in epithelial ovarian cancer incidence

Conference Cancer Research · August 15, 2020 AbstractPurpose. Although the incidence of epithelial ovarian cancer is highest among non-Hispanic white women, African-American women have the worst survival of all racial/ethnic groups. We hypothesize that ... Full text Cite

Cardiometabolic comorbidities and epithelial ovarian cancer risk among African-American women in the African-American Cancer Epidemiology Study (AACES).

Journal Article Gynecol Oncol · July 2020 BACKGROUND: Studies that have examined the association between cardiovascular comorbidities and epithelial ovarian cancer (EOC) have yielded inconsistent results. It remains unknown whether cardiometabolic disease is associated with EOC in African American ... Full text Link to item Cite

Identification of novel epithelial ovarian cancer loci in women of African ancestry.

Journal Article Int J Cancer · June 1, 2020 Women of African ancestry have lower incidence of epithelial ovarian cancer (EOC) yet worse survival compared to women of European ancestry. We conducted a genome-wide association study in African ancestry women with 755 EOC cases, including 537 high-grade ... Full text Link to item Cite

Urinary Estrogen Metabolites and Long-Term Mortality Following Breast Cancer.

Journal Article JNCI Cancer Spectr · June 2020 BACKGROUND: Estrogen metabolite concentrations of 2-hydroxyestrone (2-OHE1) and 16-hydroxyestrone (16-OHE1) may be associated with breast carcinogenesis. However, no study has investigated their possible impact on mortality after breast cancer. METHODS: Th ... Full text Link to item Cite

Novel genetic variants in genes of the Fc gamma receptor-mediated phagocytosis pathway predict non-small cell lung cancer survival.

Journal Article Transl Lung Cancer Res · June 2020 BACKGROUND: Both antibody-dependent cellular cytotoxicity and phagocytosis activate innate immunity, and the Fc gamma receptor (FCGR)-mediated phagocytosis is an integral part of the process. We assessed associations between single-nucleotide polymorphisms ... Full text Open Access Link to item Cite

Abstract C038: First- and second-degree family history of ovarian and breast cancers in relation to risk of invasive ovarian cancer in African American and White women

Conference Cancer Epidemiology, Biomarkers & Prevention · June 1, 2020 AbstractBackground: Family history of ovarian and breast cancers is a well-established risk factor for ovarian cancer and recent findings suggest that the risk of ovarian cancer may be higher for African Ame ... Full text Cite

Abstract C070: Racial disparities in body mass index and ovarian cancer risk in the OCWAA Consortium

Conference Cancer Epidemiology, Biomarkers & Prevention · June 1, 2020 AbstractObjective: Obesity disproportionately affects African American (AA) women, and there is some suggestion that its association with ovarian cancer risk may be stronger among AA compared to white women, ... Full text Cite

Abstract C044: Dietary inflammatory potential prior to diagnosis and risk of all-cause mortality among African-American women with ovarian carcinoma

Conference Cancer Epidemiology, Biomarkers & Prevention · June 1, 2020 AbstractBackground: Chronic inflammation is known to be associated with ovarian carcinogenesis, yet the impact of inflammatory-related exposures on outcomes has been understudied. Given the poor survival for ... Full text Cite

Novel genetic variants in HDAC2 and PPARGC1A of the CREB-binding protein pathway predict survival of non-small-cell lung cancer.

Journal Article Mol Carcinog · January 2020 The CREB-binding protein (CBP) pathway plays an important role in transcription and activity of acetyltransferase that acetylates lysine residues of histones and nonhistone proteins. In the present study, we hypothesized that genetic variants in the CBP pa ... Full text Open Access Link to item Cite

Perceived discrimination, trust in physicians, and prolonged symptom duration before ovarian cancer diagnosis in the African American Cancer Epidemiology Study.

Journal Article Cancer · December 15, 2019 BACKGROUND: Discrimination and trust are known barriers to accessing health care. Despite well-documented racial disparities in the ovarian cancer care continuum, the role of these barriers has not been examined. This study evaluated the association of eve ... Full text Link to item Cite

Genetic variants of genes in the NER pathway associated with risk of breast cancer: A large-scale analysis of 14 published GWAS datasets in the DRIVE study.

Journal Article Int J Cancer · September 1, 2019 A recent hypothesis-free pathway-level analysis of genome-wide association study (GWAS) datasets suggested that the overall genetic variation measured by single nucleotide polymorphisms (SNPs) in the nucleotide excision repair (NER) pathway genes was assoc ... Full text Open Access Link to item Cite

Prediagnostic Proinflammatory Dietary Potential Is Associated with All-Cause Mortality among African-American Women with High-Grade Serous Ovarian Carcinoma.

Journal Article J Nutr · September 1, 2019 BACKGROUND: Chronic inflammation is associated with ovarian carcinogenesis; yet, the impact of inflammatory-related exposures on outcomes has been understudied. OBJECTIVE: Given the poor survival of women diagnosed with ovarian cancer, especially African-A ... Full text Link to item Cite

Ovarian Cancer in Women of African Ancestry (OCWAA) consortium: a resource of harmonized data from eight epidemiologic studies of African American and white women.

Journal Article Cancer Causes Control · September 2019 PURPOSE: Although the incidence rate of epithelial ovarian cancer (EOC) is somewhat lower in African American (AA) than white women, survival is worse. The Ovarian Cancer in Women of African Ancestry (OCWAA) consortium will overcome small, study-specific s ... Full text Link to item Cite

Genetic variants in RUNX3, AMD1 and MSRA in the methionine metabolic pathway and survival in nonsmall cell lung cancer patients.

Journal Article Int J Cancer · August 1, 2019 Abnormal methionine dependence in cancer cells has led to methionine restriction as a potential therapeutic strategy. We hypothesized that genetic variants involved in methionine-metabolic genes are associated with survival in nonsmall cell lung cancer (NS ... Full text Open Access Link to item Cite

Potentially functional genetic variants in the TNF/TNFR signaling pathway genes predict survival of patients with non-small cell lung cancer in the PLCO cancer screening trial.

Journal Article Mol Carcinog · July 2019 The tumor necrosis factor (TNF)/TNF receptor (TNFR) pathway is known to influence survival of patients with cancer. We hypothesize that single nucleotide polymorphisms (SNPs) in the TNF/TNFR pathway genes related to apoptosis are associated with survival o ... Full text Open Access Link to item Cite

Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women.

Journal Article Cancer Med · May 2019 An association between genetic variants in the vitamin D receptor (VDR) gene and epithelial ovarian cancer (EOC) was previously reported in women of African ancestry (AA). We sought to examine associations between genetic variants in VDR and additional gen ... Full text Link to item Cite

Potentially functional genetic variants in the complement-related immunity gene-set are associated with non-small cell lung cancer survival.

Journal Article Int J Cancer · April 15, 2019 The complement system plays an important role in the innate and adaptive immunity, complement components mediate tumor cytolysis of antibody-based immunotherapy, and complement activation in the tumor microenvironment may promote tumor progression or inhib ... Full text Open Access Link to item Cite

Effect of Cultural, Folk, and Religious Beliefs and Practices on Delays in Diagnosis of Ovarian Cancer in African American Women.

Journal Article J Womens Health (Larchmt) · April 2019 BACKGROUND: Certain cultural, folk, and religious beliefs that are more common among African Americans (AAs) have been associated with later-stage breast cancer. It is unknown if these beliefs are similarly associated with delays in diagnosis of ovarian ca ... Full text Link to item Cite

Targetable Immune Regulatory Molecule Expression in High-Grade Serous Ovarian Carcinomas in African American Women: A Study of PD-L1 and IDO in 112 Cases From the African American Cancer Epidemiology Study (AACES).

Journal Article Int J Gynecol Pathol · March 2019 African American women with high-grade serous ovarian carcinoma have worse outcomes compared with women of European descent. Although the discrepancy is partially attributed to differences in access to care, the tumor immune microenvironment may also contr ... Full text Link to item Cite

Individual, Social, and Societal Correlates of Health-Related Quality of Life Among African American Survivors of Ovarian Cancer: Results from the African American Cancer Epidemiology Study.

Journal Article J Womens Health (Larchmt) · February 2019 OBJECTIVE: While the incidence of epithelial ovarian cancer (EOC) is lower among African American (AA) women compared with European American (EA) women, AA women have markedly worse outcomes. In this study, we describe individual, social, and societal fact ... Full text Link to item Cite

Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk.

Journal Article Cancer Res · February 1, 2019 DNA methylation is instrumental for gene regulation. Global changes in the epigenetic landscape have been recognized as a hallmark of cancer. However, the role of DNA methylation in epithelial ovarian cancer (EOC) remains unclear. In this study, high-densi ... Full text Link to item Cite

Benign gynecologic conditions are associated with ovarian cancer risk in African-American women: a case-control study.

Journal Article Cancer Causes Control · November 2018 BACKGROUND: The association between common benign gynecologic conditions and ovarian cancer remains under-studied in African Americans. Therefore, we examine the association between self-reported history of benign gynecologic conditions and epithelial ovar ... Full text Link to item Cite

Single-nucleotide polymorphisms of stemness genes predicted to regulate RNA splicing, microRNA and oncogenic signaling are associated with prostate cancer survival.

Journal Article Carcinogenesis · July 3, 2018 Prostate cancer (PCa) is a clinically and molecularly heterogeneous disease, with variation in outcomes only partially predicted by grade and stage. Additional tools to distinguish indolent from aggressive disease are needed. Phenotypic characteristics of ... Full text Open Access Link to item Cite

Determinants of delays in care-seeking for ovarian cancer symptoms in African American women.

Conference CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION · July 1, 2018 Link to item Cite

Abstract 5318: High-grade serous ovarian cancer DNA methylation and survival in African-American women

Conference Cancer Research · July 1, 2018 AbstractOvarian cancer is the most lethal gynecologic cancer in the United States, and African-American (AA) women have the poorest outcomes compared to other racial/ethnic groups. Although several biomarker ... Full text Cite

Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies.

Journal Article Int J Epidemiol · April 1, 2018 BACKGROUND: Ovarian cancer incidence differs substantially by race/ethnicity, but the reasons for this are not well understood. Data were pooled from the African American Cancer Epidemiology Study (AACES) and 11 case-control studies in the Ovarian Cancer A ... Full text Link to item Cite

Race, Menopausal Hormone Therapy, and Invasive Breast Cancer in the Carolina Breast Cancer Study.

Journal Article J Womens Health (Larchmt) · March 2018 PURPOSE: The use of combined estrogen-progestin menopausal hormone therapy (MHT) has been shown to increase the risk of breast cancer, however, recent observational studies have suggested that the association between MHT and breast cancer may be modified b ... Full text Link to item Cite

Recreational physical activity and survival in African-American women with ovarian cancer.

Journal Article Cancer Causes Control · January 2018 PURPOSE: While recreational physical activity (RPA) has been associated with reduced mortality in breast, colorectal, and prostate cancers, evidence for epithelial ovarian cancer (EOC) is limited. Most EOC studies have been in predominantly white populatio ... Full text Link to item Cite

Tubal ligation and ovarian cancer risk in African American women.

Journal Article Cancer Causes Control · October 2017 PURPOSE: Tubal ligation has been associated with reduced risk of epithelial ovarian cancer (EOC) in studies of primarily white women, but less is known about the association in African American (AA) women. We sought to evaluate the associations among 597 i ... Full text Link to item Cite

Associations between RNA splicing regulatory variants of stemness-related genes and racial disparities in susceptibility to prostate cancer.

Journal Article Int J Cancer · August 15, 2017 Evidence suggests that cells with a stemness phenotype play a pivotal role in oncogenesis, and prostate cells exhibiting this phenotype have been identified. We used two genome-wide association study (GWAS) datasets of African descendants, from the Multiet ... Full text Link to item Cite

Premenopausal Hysterectomy and Risk of Ovarian Cancer in African-American Women.

Journal Article Am J Epidemiol · July 1, 2017 Although the inverse association between hysterectomy and epithelial ovarian cancer (EOC) was considered well established, investigators in recent studies including women diagnosed after 2000 have observed modest increases in risk. Most studies have been c ... Full text Link to item Cite

Cigarette smoking and the association with serous ovarian cancer in African American women: African American Cancer Epidemiology Study (AACES).

Journal Article Cancer Causes Control · July 2017 BACKGROUND: Smoking is a risk factor for mucinous ovarian cancer (OvCa) in Caucasians. Whether a similar association exists in African Americans (AA) is unknown. METHODS: We conducted a population-based case-control study of incident OvCa in AA women acros ... Full text Link to item Cite

Dietary Quality and Ovarian Cancer Risk in African-American Women.

Journal Article Am J Epidemiol · June 15, 2017 This study evaluated 3 index-based dietary patterns-Healthy Eating Index (HEI)-2005, HEI-2010, and Alternate Healthy Eating Index (AHEI)-2010-in relation to ovarian cancer risk in African-American women. The study was conducted among 415 ovarian cancer cas ... Full text Link to item Cite

Lifetime number of ovulatory cycles and epithelial ovarian cancer risk in African American women.

Journal Article Cancer Causes Control · May 2017 PURPOSE: Incessant ovulation has been consistently linked to epithelial ovarian cancer (EOC). Although reproductive characteristics differ substantially by race, the association between incessant ovulation and EOC has been evaluated only in populations of ... Full text Link to item Cite

Supplemental Selenium May Decrease Ovarian Cancer Risk in African-American Women.

Journal Article J Nutr · April 2017 Background: To our knowledge, no previous study has evaluated the associations of antioxidant intake with the risk of ovarian cancer in African-American women, who are known to have high mortality from the disease.Objective: We sought to evaluate these ass ... Full text Link to item Cite

Dietary inflammatory index and risk of epithelial ovarian cancer in African American women.

Journal Article Int J Cancer · February 1, 2017 Chronic inflammation has been implicated in the development of epithelial ovarian cancer (EOC); yet the contribution of inflammatory foods and nutrients to EOC risk has been understudied. We investigated the association between the dietary inflammatory ind ... Full text Link to item Cite

Physical and psychological health in rare cancer survivors.

Journal Article J Cancer Surviv · February 2017 PURPOSE: Registries provide a unique tool for tracking quality of life in rare cancer survivors, whose survivorship experience is less known than for common cancers. This paper reports on these outcomes in 321 patients enrolled in the Rare Cancer Genetics ... Full text Link to item Cite

Abstract B51: Dairy, calcium, vitamin D and ovarian cancer risk in African-American women

Conference Cancer Epidemiology, Biomarkers & Prevention · February 1, 2017 AbstractBackground: Ovarian cancer is the leading cause of death from gynecologic cancers in the US. Currently there is no reliable screening available for ovarian cancer. Most cases are diagnosed at an adva ... Full text Cite

Engaging African Americans in Research: The Recruiter's Perspective.

Journal Article Ethn Dis · 2017 PURPOSE: To examine barriers recruiters encounter when enrolling African American study participants, identify motivating factors to increase research participation, and provide recommendations to facilitate successful minority recruitment. BACKGROUND: Rec ... Full text Open Access Link to item Cite

Dairy, calcium, vitamin D and ovarian cancer risk in African-American women.

Journal Article Br J Cancer · October 25, 2016 BACKGROUND: No previous study has evaluated the associations of dairy products, lactose, calcium and vitamin D with the risk of ovarian cancer in African-American women, who are known to have high mortality from the disease, as well as to be at risk for ca ... Full text Link to item Cite

Association between Body Powder Use and Ovarian Cancer: The African American Cancer Epidemiology Study (AACES).

Journal Article Cancer Epidemiol Biomarkers Prev · October 2016 BACKGROUND: Epidemiologic studies indicate increased ovarian cancer risk among women who use genital powder, but this has not been thoroughly investigated in African American (AA) women, a group with a high prevalence of use. We evaluate the relationship b ... Full text Link to item Cite

Reproductive factors and ovarian cancer risk in African-American women.

Journal Article Ann Epidemiol · September 2016 PURPOSE: Reproductive characteristics, the most established ovarian cancer risk factors, differ markedly between African-American and white women. Studies in predominantly white populations suggest that associations between reproductive characteristics and ... Full text Link to item Cite

In Reply.

Journal Article Obstet Gynecol · September 2016 Full text Link to item Cite

Socioeconomic Status in Relation to the Risk of Ovarian Cancer in African-American Women: A Population-Based Case-Control Study.

Journal Article Am J Epidemiol · August 15, 2016 We investigated the association between socioeconomic status and ovarian cancer in African-American women. We used a population-based case-control study design that included case patients with incident ovarian cancer (n = 513) and age- and area-matched con ... Full text Link to item Cite

Obesity, weight gain, and ovarian cancer risk in African American women.

Journal Article Int J Cancer · August 1, 2016 Although there is growing evidence that higher adiposity increases ovarian cancer risk, little is known about its impact in African American (AA) women, the racial/ethnic group with the highest prevalence of obesity. We evaluated the impact of body mass in ... Full text Link to item Cite

Abstract 3407: Gene expression subtypes of high grade serous ovarian cancer in African American women

Conference Cancer Research · July 15, 2016 AbstractOvarian cancer accounts for 5% of cancer deaths and is the fifth leading cause of cancer death in women in the United States. While incidence is higher in European American (EA) than African American ... Full text Cite

Abstract 1754: Body powder use and ovarian cancer: the African American Cancer Epidemiology Study

Conference Cancer Research · July 15, 2016 AbstractFindings of epidemiologic studies indicate an increased risk of ovarian cancer among women who use powders applied to perineal areas. Although African American (AA) women have a high prevalence of po ... Full text Cite

The Association Between Body Mass Index and Presenting Symptoms in African American Women with Ovarian Cancer.

Journal Article J Womens Health (Larchmt) · June 2016 BACKGROUND: Ovarian cancer, the most lethal gynecologic malignancy, typically comes to clinical attention due to nonspecific gastrointestinal or pelvic symptoms. African Americans with ovarian cancer have a greater mortality burden than whites and are also ... Full text Link to item Cite

Recreational physical activity and ovarian cancer risk in African American women.

Journal Article Cancer Med · June 2016 The literature on recreational physical activity (RPA) and ovarian cancer risk is inconclusive and most studies of RPA and ovarian cancer have been conducted in white populations. This study is the first to investigate the association between RPA and ovari ... Full text Link to item Cite

Association of Ovary-Sparing Hysterectomy With Ovarian Reserve.

Journal Article Obstet Gynecol · May 2016 OBJECTIVE: To evaluate the association of hysterectomy on ovarian function by comparing antimüllerian hormone, a marker of ovarian reserve, before and after hysterectomy. METHODS: The Prospective Research on Ovarian Function study prospectively followed 1) ... Full text Link to item Cite

Analgesic medication use and risk of epithelial ovarian cancer in African American women.

Journal Article Br J Cancer · March 29, 2016 BACKGROUND: Existing literature examining analgesic medication use and epithelial ovarian cancer (EOC) risk has been inconsistent, with the majority of studies reporting an inverse association. Race-specific effects of this relationship have not been adequ ... Full text Link to item Cite

Abstract A73: Obesity, weight gain, and ovarian cancer risk in African American women

Conference Cancer Epidemiology, Biomarkers & Prevention · March 1, 2016 AbstractBackground: There is growing evidence that obesity increases ovarian cancer risk. However, little is known about the impact of body fatness and weight gain in African American women, the racial/ethni ... Full text Cite

Abstract PR05: Dietary quality and ovarian cancer risk in African American women

Conference Cancer Epidemiology, Biomarkers & Prevention · March 1, 2016 AbstractBackground: Ovarian cancer is the fifth leading cause of cancer death among women in the US. Considering the poor survival rates, identifying modifiable lifestyle factors including dietary interventi ... Full text Cite

Dietary carbohydrate intake, glycaemic load, glycaemic index and ovarian cancer risk in African-American women.

Journal Article Br J Nutr · February 28, 2016 Epidemiological evidence regarding the association between carbohydrate intake, glycaemic load (GL) and glycaemic index (GI) and risk of ovarian cancer has been mixed. Little is known about their impact on ovarian cancer risk in African-American women. Ass ... Full text Link to item Cite

Benefits and Harms of Breast Cancer Screening: A Systematic Review.

Journal Article JAMA · October 20, 2015 IMPORTANCE: Patients need to consider both benefits and harms of breast cancer screening. OBJECTIVE: To systematically synthesize available evidence on the association of mammographic screening and clinical breast examination (CBE) at different ages and in ... Full text Link to item Cite

Risk-benefit assessment of the combined oral contraceptive pill in women with a family history of female cancer.

Journal Article Expert Opin Drug Saf · October 2014 INTRODUCTION: Oral contraceptive pills (OCPs) are the most frequently used form of effective, reversible contraception among women of childbearing potential. In the average risk population, OCPs may offer a protective benefit against ovarian, endometrial a ... Full text Link to item Cite

A multi-center population-based case-control study of ovarian cancer in African-American women: the African American Cancer Epidemiology Study (AACES).

Journal Article BMC Cancer · September 22, 2014 BACKGROUND: Ovarian cancer (OVCA) is the leading cause of death from gynecological cancer, with poorer survival for African American (AA) women compared to whites. However, little is known about risk factors for OVCA in AA. To study the epidemiology of OVC ... Full text Link to item Cite

Non-steroidal anti-inflammatory drug use, hormone receptor status, and breast cancer-specific mortality in the Carolina Breast Cancer Study.

Journal Article Breast Cancer Res Treat · September 2014 Epidemiologic studies report a protective association between non-steroidal anti-inflammatory drug (NSAID) use and hormone receptor-positive breast cancer risk, a finding consistent with NSAID-mediated suppression of aromatase-driven estrogen biosynthesis. ... Full text Link to item Cite

The association between race and prostate cancer risk on initial biopsy in an equal access, multiethnic cohort.

Conference Cancer Causes Control · August 2014 PURPOSE: Population-based studies have established a link between race and prostate cancer (PC) risk, but whether race predicts PC after adjusting for clinical characteristics is unclear. We investigated the association between race and risk of low- and hi ... Full text Link to item Cite

Long-term risk of medical conditions associated with breast cancer treatment.

Journal Article Breast Cancer Res Treat · May 2014 Early and late effects of cancer treatment are of increasing concern with growing survivor populations, but relevant data are sparse. We sought to determine the prevalence and hazard ratio of such effects in breast cancer cases. Women with invasive breast ... Full text Link to item Cite

Challenges and Recommendations to Recruiting Women Who Do Not Adhere to Follow-Up Gynecological Care.

Journal Article Open J Prev Med · March 20, 2014 PURPOSE: Non-adherence to recommended follow-up visits after an abnormal cytological finding is associated with poorer outcomes and higher health care costs. The purpose of this paper is to describe the challenges when examining reasons for non-adherence t ... Full text Link to item Cite

Anti-Mullerian Hormone and Ovarian Function after Hysterectomy

Journal Article REPRODUCTIVE SCIENCES · March 1, 2014 Link to item Cite

Metformin does not affect risk of biochemical recurrence following radical prostatectomy: Results from the SEARCH database

Journal Article Prostate Cancer and Prostatic Diseases · December 1, 2013 Background:While epidemiologic studies suggest that metformin use among diabetics may decrease prostate cancer (PC) incidence, the effect of metformin use on PC outcome is unclear. We investigated the association between pre-operative metformin use, dose a ... Full text Cite

Metformin does not affect risk of biochemical recurrence following radical prostatectomy: results from the SEARCH database.

Journal Article Prostate Cancer Prostatic Dis · December 2013 BACKGROUND: While epidemiologic studies suggest that metformin use among diabetics may decrease prostate cancer (PC) incidence, the effect of metformin use on PC outcome is unclear. We investigated the association between pre-operative metformin use, dose ... Full text Link to item Cite

Oral contraceptives and risk of ovarian cancer and breast cancer among high-risk women: a systematic review and meta-analysis.

Journal Article J Clin Oncol · November 20, 2013 Featured Publication PURPOSE: To estimate the risks of ovarian cancer and breast cancer associated with oral contraceptive (OC) use among women at elevated risk owing to mutations in BRCA1/2 or a strong family history. METHODS: We searched PubMed, Embase, the Cochrane Database ... Full text Link to item Cite

Oral contraceptive use and risk of breast, cervical, colorectal, and endometrial cancers: a systematic review.

Journal Article Cancer Epidemiol Biomarkers Prev · November 2013 Oral contraceptives may influence the risk of certain cancers. As part of the AHRQ Evidence Report, Oral Contraceptive Use for the Primary Prevention of Ovarian Cancer, we conducted a systematic review to estimate associations between oral contraceptive us ... Full text Link to item Cite

Risk of acute thromboembolic events with oral contraceptive use: a systematic review and meta-analysis.

Journal Article Obstet Gynecol · August 2013 OBJECTIVE: To estimate the risk of venous thromboembolism, stroke, or myocardial infarction (MI) associated with the use of oral contraceptive pills (OCPs) and to describe how these risks vary by dose or formulation. DATA SOURCES: We searched PubMed, Embas ... Full text Link to item Cite

Oral contraceptive pills as primary prevention for ovarian cancer: a systematic review and meta-analysis.

Journal Article Obstet Gynecol · July 2013 Featured Publication OBJECTIVE: To estimate the overall reduction in ovarian cancer risk associated with the use of oral contraceptive pills (OCPs) and whether reduction in risk is affected by specifics of OCP use, such as formulation or duration of use. DATA SOURCES: We searc ... Full text Link to item Cite

Oral contraceptive use for the primary prevention of ovarian cancer.

Journal Article Evid Rep Technol Assess (Full Rep) · June 2013 OBJECTIVE: To estimate the overall balance of harms and benefits from the potential use of oral contraceptives (OCs) for the primary prevention of ovarian cancer DATA SOURCES: We searched PubMed®, Embase®, the Cochrane Database of Systematic Reviews, and C ... Link to item Cite

Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2013 BACKGROUND: There are several well-established environmental risk factors for ovarian cancer, and recent genome-wide association studies have also identified six variants that influence disease risk. However, the interplay between such risk factors and sus ... Full text Link to item Cite

Obesity and risk of ovarian cancer subtypes: evidence from the Ovarian Cancer Association Consortium.

Journal Article Endocr Relat Cancer · April 2013 Whilst previous studies have reported that higher BMI increases a woman's risk of developing ovarian cancer, associations for the different histological subtypes have not been well defined. As the prevalence of obesity has increased dramatically, and class ... Full text Link to item Cite

Comparison of characteristics of fibroids in African American and white women undergoing premenopausal hysterectomy.

Journal Article Fertil Steril · March 1, 2013 Featured Publication OBJECTIVE: To compare pathologic characteristics and epidemiologic risk factors for uterine fibroids in African American and white women undergoing hysterectomy. DESIGN: Cross-sectional analysis of women undergoing premenopausal hysterectomy. SETTING: Two ... Full text Link to item Cite

Risk of acute thromboembolic events with oral contraceptive use: a systematic review and meta-analysis.

Journal Article Obstetrics and gynecology · January 1, 2013 To estimate the risk of venous thromboembolism, stroke, or myocardial infarction (MI) associated with the use of oral contraceptive pills (OCPs) and to describe how these risks vary by dose or formulation. We searched PubMed, Embase, the Cochrane Database ... Cite

Factors Associated With Adherence to Follow-up Colposcopy.

Journal Article Am J Health Educ · 2013 BACKGROUND: Understanding the gaps in knowledge about human papilloma virus (HPV) infection, transmission, and health consequences and factors associated with the knowledge gap is an essential first step for the development of interventions to improve adhe ... Full text Link to item Cite

Satisfaction guaranteed? An analysis of lecturer characteristics associated with physician assistant student satisfaction.

Other The journal of physician assistant education : the official journal of the Physician Assistant Education Association · 2012 Cite

Effect of hysterectomy with ovarian preservation on ovarian function.

Journal Article Obstet Gynecol · December 2011 Featured Publication OBJECTIVE: To prospectively estimate the risk for earlier ovarian failure among women undergoing hysterectomy with ovarian preservation, as compared with women of similar age without hysterectomy. METHODS: A prospective cohort study was conducted among wom ... Full text Link to item Cite

Clinically relevant changes in family history of cancer over time.

Journal Article JAMA · July 13, 2011 CONTEXT: Knowledge of family cancer history is important for assessing cancer risk and guiding screening recommendations. OBJECTIVE: To quantify how often throughout adulthood clinically significant changes occur in cancer family history that would result ... Full text Link to item Cite

Reported symptoms before and one year after hysterectomy in African American and white women.

Journal Article J Womens Health (Larchmt) · July 2011 PURPOSE: Although African American women are more likely than white women to undergo hysterectomy, there are few data describing their symptoms before and after surgery. This report compares reported symptoms in white and African American women before and ... Full text Link to item Cite

Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk.

Journal Article Hum Mol Genet · June 1, 2011 The insulin-like growth factor (IGF) signaling axis plays an important role in cancer biology. We hypothesized that genetic variation in this pathway may influence risk of ovarian cancer. A three-center study of non-Hispanic whites including 1880 control w ... Full text Link to item Cite

Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer.

Journal Article Int J Cancer · May 1, 2011 Common germline genetic variation in the population is associated with susceptibility to epithelial ovarian cancer. Microcell-mediated chromosome transfer and expression microarray analysis identified nine genes associated with functional suppression of tu ... Full text Link to item Cite

Recreational physical activity and ovarian cancer risk and survival.

Journal Article Ann Epidemiol · March 2011 PURPOSE: Physical activity may influence ovarian cancer risk and outcomes through effects on ovulation, inflammatory markers, and other processes. We examined associations between self-reported physical activity and ovarian cancer risk and survival in a po ... Full text Link to item Cite

Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort.

Journal Article Fertil Steril · January 2011 OBJECTIVE: To investigate the association between self-reported endometriosis and the putative functional promoter +331C/T single nucleotide polymorphism and the PROGINS allele. DESIGN: Control subjects from ovarian cancer case-control studies participatin ... Full text Link to item Cite

Evaluation of established breast cancer risk factors as modifiers of BRCA1 or BRCA2: a multi-center case-only analysis.

Journal Article Breast Cancer Res Treat · November 2010 Featured Publication The incomplete penetrance of mutations in BRCA1 and BRCA2 suggests that some combination of environmental and genetic factors modifies the risk of breast cancer in mutation carriers. This study sought to identify possible interactions between established b ... Full text Link to item Cite

Common variants at 19p13 are associated with susceptibility to ovarian cancer.

Journal Article Nat Genet · October 2010 Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 indi ... Full text Link to item Cite

Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".

Journal Article PLoS Genet · July 8, 2010 We hypothesized that variants in genes expressed as a consequence of interactions between ovarian cancer cells and the host micro-environment could contribute to cancer susceptibility. We therefore used a two-stage approach to evaluate common single nucleo ... Full text Link to item Cite

Primary peritoneal and ovarian cancers: an epidemiological comparative analysis.

Journal Article Cancer Causes Control · July 2010 We performed case-control analyses using data from the North Carolina Ovarian Cancer Study to determine risk factors that distinguish primary peritoneal cancer (PPC) from epithelial ovarian cancer (EOC). Our risk factor analyses were restricted to invasive ... Full text Link to item Cite

Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · July 2010 BACKGROUND: We previously reported the risks of ovarian carcinoma for common polymorphisms in one-carbon transfer genes. We sought to replicate associations for DPYD rs1801265, DNMT3A rs13420827, MTHFD1 rs1950902, MTHFS rs17284990, and TYMS rs495139 with r ... Full text Link to item Cite

Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".

Journal Article PLoS genetics · July 1, 2010 We hypothesized that variants in genes expressed as a consequence of interactions between ovarian cancer cells and the host micro-environment could contribute to cancer susceptibility. We therefore used a two-stage approach to evaluate common single nucleo ... Cite

Association between DNA damage response and repair genes and risk of invasive serous ovarian cancer.

Journal Article PLoS One · April 8, 2010 BACKGROUND: We analyzed the association between 53 genes related to DNA repair and p53-mediated damage response and serous ovarian cancer risk using case-control data from the North Carolina Ovarian Cancer Study (NCOCS), a population-based, case-control st ... Full text Open Access Link to item Cite

ESR1/SYNE1 polymorphism and invasive epithelial ovarian cancer risk: an Ovarian Cancer Association Consortium study.

Journal Article Cancer Epidemiol Biomarkers Prev · January 2010 We genotyped 13 single nucleotide polymorphisms (SNPs) in the estrogen receptor alpha gene (ESR1) region in three population-based case-control studies of epithelial ovarian cancer conducted in the United States, comprising a total of 1,128 and 1,866 non-H ... Full text Link to item Cite

Genetics and women's health issues--the commitment of EMS to women scientists and gender-associated disease topics.

Journal Article Environ Mol Mutagen · 2010 This manuscript presents an overview of a symposium held at the 2009 annual meeting of the Environmental Mutagen Society (EMS) in St. Louis, MO. The symposium was sponsored by the Women in the Environmental Mutagen Society (WEMS) special interest group, an ... Full text Link to item Cite

A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2.

Journal Article Nat Genet · September 2009 Epithelial ovarian cancer has a major heritable component, but the known susceptibility genes explain less than half the excess familial risk. We performed a genome-wide association study (GWAS) to identify common ovarian cancer susceptibility alleles. We ... Full text Link to item Cite

Ovarian cancer risk factors in African-American and white women.

Journal Article Am J Epidemiol · September 1, 2009 Featured Publication Ovarian cancer is the most lethal gynecologic malignancy in both African-American and white women. Although prevalences of many ovarian cancer risk factors differ markedly between African Americans and whites, there has been little research on how the rela ... Full text Link to item Cite

Challenges of Epidemiologic Research in the Genomic Era: The Example of Ovarian Cancer

Journal Article ENVIRONMENTAL AND MOLECULAR MUTAGENESIS · August 1, 2009 Link to item Cite

Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study.

Journal Article Hum Mol Genet · June 15, 2009 Because both ovarian and breast cancer are hormone-related and are known to have some predisposition genes in common, we evaluated 11 of the most significant hits (six with confirmed associations with breast cancer) from the breast cancer genome-wide assoc ... Full text Link to item Cite

A prospective study of weight gain after premenopausal hysterectomy.

Journal Article J Womens Health (Larchmt) · May 2009 Featured Publication PURPOSE: Many women who have had hysterectomies have the perception that they gained weight after surgery that cannot be attributed to changes in diet or physical activity. The purpose of this analysis was to assess weight gain in premenopausal women in th ... Full text Link to item Cite

Association between glioma and history of allergies, asthma, and eczema: a case-control study with three groups of controls.

Journal Article Cancer Epidemiol Biomarkers Prev · April 2009 Because glioma etiology is largely unknown, the inverse association of glioma risk with atopic conditions is promising and deserves close scrutiny. We examined the association between a history of allergies, asthma, and eczema, and glioma risk using siblin ... Full text Link to item Cite

Single nucleotide polymorphisms in the TP53 region and susceptibility to invasive epithelial ovarian cancer.

Journal Article Cancer Res · March 15, 2009 Featured Publication The p53 protein is critical for multiple cellular functions including cell growth and DNA repair. We assessed whether polymorphisms in the region encoding TP53 were associated with risk of invasive ovarian cancer. The study population includes a total of 5 ... Full text Link to item Cite

Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium.

Journal Article Br J Cancer · January 27, 2009 The search for genetic variants associated with ovarian cancer risk has focused on pathways including sex steroid hormones, DNA repair, and cell cycle control. The Ovarian Cancer Association Consortium (OCAC) identified 10 single-nucleotide polymorphisms ( ... Full text Link to item Cite

Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.

Journal Article Cancer Epidemiol Biomarkers Prev · December 2008 Over 22,000 cases of ovarian cancer were diagnosed in 2007 in the United States, but only a fraction of them can be attributed to mutations in highly penetrant genes such as BRCA1. To determine whether low-penetrance genetic variants contribute to ovarian ... Full text Link to item Cite

Consortium analysis of 7 candidate SNPs for ovarian cancer.

Journal Article Int J Cancer · July 15, 2008 The Ovarian Cancer Association Consortium selected 7 candidate single nucleotide polymorphisms (SNPs), for which there is evidence from previous studies of an association with variation in ovarian cancer or breast cancer risks. The SNPs selected for analys ... Full text Link to item Cite

Weight gain after pre-menopausal hysterectomy

Conference AMERICAN JOURNAL OF EPIDEMIOLOGY · June 1, 2008 Link to item Cite

Epidemiology of basal-like breast cancer.

Journal Article Breast Cancer Res Treat · May 2008 Featured Publication Risk factors for the newly identified "intrinsic" breast cancer subtypes (luminal A, luminal B, basal-like and human epidermal growth factor receptor 2-positive/estrogen receptor-negative) were determined in the Carolina Breast Cancer Study, a population-b ... Full text Link to item Cite

Hormonal risk factors for ovarian cancer in premenopausal and postmenopausal women.

Journal Article Am J Epidemiol · May 1, 2008 Featured Publication Ovarian cancer is most frequently diagnosed in postmenopausal women; however, the strongest risk predictors, pregnancy and oral contraceptive use, occur in most women in their twenties and thirties. Relatively few studies have examined how reproductive ris ... Full text Link to item Cite

Cyclin E overexpression in epithelial ovarian cancer characterizes an etiologic subgroup.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2008 BACKGROUND: The objective of this study was to determine whether cyclin E overexpression defines an etiologically distinct subgroup of ovarian cancer. METHODS: We analyzed data from 538 epithelial ovarian cancer cases and 629 controls enrolled in a populat ... Full text Link to item Cite

Breast cancer: hormones and other risk factors.

Journal Article Maturitas · 2008 UNLABELLED: In North America and Northern Europe, breast cancer incidence rates begin increasing in the early reproductive years and continue climbing into the late seventies, whereas rates plateau after menopause in Japan and less developed countries. Fem ... Full text Link to item Cite

Oral contraceptives and survival in breast cancer patients aged 20 to 54 years.

Journal Article Cancer Epidemiol Biomarkers Prev · September 2007 Recent oral contraceptive (OC) use is associated with modestly higher breast cancer incidence among younger women, but its impact on survival is unclear. This study examined the relationship between OC use before breast cancer diagnosis and survival. A pop ... Full text Link to item Cite

Age and menopausal effects of hormonal birth control and hormone replacement therapy in relation to breast cancer risk.

Journal Article Am J Epidemiol · May 15, 2007 It is unclear whether breast cancer risk varies by age and menopausal status in relation to use of hormonal birth control (HBC) and hormone replacement therapy (HRT), taken singly or cumulatively. The authors utilized data from 1,478 cases and 1,493 contro ... Full text Link to item Cite

Association between reproductive factors and breast cancer survival in younger women.

Journal Article Breast Cancer Res Treat · May 2007 This analysis investigated whether reproductive factors such as age at menarche, parity, and timing and outcomes of pregnancies were associated with survival among women with breast cancer younger than 55 years. Female residents of Atlanta, Georgia, and ce ... Full text Link to item Cite

Reproductive factors and breast cancer risk among older women.

Journal Article Breast Cancer Res Treat · May 2007 Reproductive factors have been shown to affect pre- and postmenopausal breast cancer risk differently, but whether there are additional age-specific differences among menopausal women as they age has not been clarified. We analyzed data from a large popula ... Full text Link to item Cite

Statins and cancer risk: what do we know and where do we go from here?

Journal Article Epidemiology · March 2007 The relationship between statin use and cancer risk has been evaluated in numerous observational studies and as a secondary outcome in randomized controlled trials evaluating the effects of statins on cardiovascular outcomes. Although there are plausible b ... Full text Link to item Cite

Trinucleotide repeat polymorphisms in the androgen receptor gene and risk of ovarian cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2007 INTRODUCTION: Androgens may play a role in the development of ovarian cancers. Two trinucleotide repeat polymorphisms have been described in exon 1 of the androgen receptor (AR) gene that may affect its function. Previous studies of ovarian cancer and AR r ... Full text Link to item Cite

Risk factors for breast cancer characterized by the estrogen receptor alpha A908G (K303R) mutation.

Journal Article Breast Cancer Res · 2007 INTRODUCTION: Estrogen is important in the development of breast cancer, and its biological effects are mediated primarily through the two estrogen receptors alpha and beta. A point mutation in the estrogen receptor alpha gene, ESR1, referred to as A908G o ... Full text Link to item Cite

Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study.

Journal Article JAMA · June 7, 2006 Featured Publication CONTEXT: Gene expression analysis has identified several breast cancer subtypes, including basal-like, human epidermal growth factor receptor-2 positive/estrogen receptor negative (HER2+/ER-), luminal A, and luminal B. OBJECTIVES: To determine population-b ... Full text Link to item Cite

COX-2 polymorphism, use of nonsteroidal anti-inflammatory drugs, and risk of colon cancer in African Americans (United States).

Journal Article Cancer Causes Control · April 2006 INTRODUCTION: The inducible Cyclooxygenase (COX)-2 enzyme plays an important role in inflammation and carcinogenesis. Recent reports suggest that single nucleotide polymorphisms (SNPs) in the COX-2 gene may alter enzyme function and in turn modify an indiv ... Full text Link to item Cite

Analgesic drug use and risk of ovarian cancer.

Journal Article Epidemiology · January 2006 BACKGROUND: Previous epidemiologic research suggests that analgesic use may reduce the risk of ovarian cancer, although results are not consistent. METHODS: In a population-based, case-control study, we analyzed data from 586 ovarian cancer cases and 627 m ... Full text Link to item Cite

Anthropometric measurements and epithelial ovarian cancer risk in African-American and White women.

Journal Article Cancer Causes Control · October 2005 Previous studies of anthropometric factors and ovarian cancer risk have been inconsistent and none have evaluated the association among African-American women. Data from a population-based, case-control study of 593 cases and 628 controls were used to eval ... Full text Link to item Cite

Use of nonsteroidal antiinflammatory drugs and risk of colon cancer in a population-based, case-control study of African Americans and Whites.

Journal Article Am J Epidemiol · September 15, 2005 African Americans have the highest colon cancer incidence and mortality rates among all US ethnic groups. Epidemiologic studies suggest that use of nonsteroidal antiinflammatory drugs (NSAIDs) is associated with a reduced risk of colon cancer, but no study ... Full text Link to item Cite

Pain predicts non-adherence to pap smear screening among middle-aged African American women.

Journal Article Prev Med · August 2005 BACKGROUND: Middle-aged African American women have the highest incidence and mortality of invasive cervical cancer in the United States and the lowest adherence to pap smear screening. METHODS: In 2001, we identified factors associated with non-adherence ... Full text Link to item Cite

Menopausal hormones and risk of ovarian cancer.

Journal Article Am J Obstet Gynecol · July 2005 OBJECTIVE: The objective of this study was to determine if use of menopausal hormones was associated with ovarian cancer and if risk varied by type of hormone used. STUDY DESIGN: Data from a population-based, case-control study of ovarian cancer in North C ... Full text Link to item Cite

Transforming growth factor beta receptor I polyalanine repeat polymorphism does not increase ovarian cancer risk.

Journal Article Gynecol Oncol · May 2005 OBJECTIVES: It has been suggested that the 6A allele of the type I TGFbeta receptor (TGFbetaR1) polyalanine repeat tract polymorphism may increase susceptibility to various types of cancer including ovarian cancer. METHODS: The TGFbetaR1 polyalanine polymo ... Full text Link to item Cite

Antidepressant medication use [corrected] and risk of ovarian cancer.

Journal Article Obstet Gynecol · April 2005 Featured Publication OBJECTIVE: It has been hypothesized that antidepressants may enhance cancer growth. Previous studies of antidepressant use and ovarian cancer have been inconsistent and have been limited in their ability to examine the association with selective serotonin ... Full text Link to item Cite

IGF1 (CA)19 repeat and IGFBP3 -202 A/C genotypes and the risk of prostate cancer in Black and White men.

Journal Article Cancer Epidemiol Biomarkers Prev · February 2005 We investigated the relationship between the insulin-like growth factor-1 (IGF1) cytosine-adenine repeat (CA)(19) polymorphism located upstream of the gene's transcription start site, the insulin-like growth factor binding protein-3 (IGFBP3) -202 A/C promo ... Full text Link to item Cite

Flushing and papules in a middle-aged woman.

Journal Article Obstet Gynecol · February 2005 Full text Link to item Cite

Comparative analysis of breast cancer risk factors among African-American women and White women.

Journal Article Am J Epidemiol · January 1, 2005 The authors assessed risk factor profiles among 1,505 African-American and 1,809 White women in the 1993-2001 Carolina Breast Cancer Study. Multiple logistic regression models for case-control data were used to estimate odds ratios for several factors. Rac ... Full text Link to item Cite

Racial differences in enrolment in a cancer genetics registry.

Journal Article Cancer Epidemiol Biomarkers Prev · August 2004 BACKGROUND: Lower enrolment of minorities into research studies has been reported frequently. Most studies have little information about nonparticipants, making it difficult to identify characteristics associated with enrolment and how they might vary by r ... Link to item Cite

Consumption of dairy products and the risk of breast cancer: a review of the literature.

Journal Article Am J Clin Nutr · July 2004 Differences in eating patterns and breast cancer rates across countries suggest that several dietary components, including dairy products, could affect breast cancer risk. However, dairy products are a diverse food group in terms of the factors that could ... Full text Link to item Cite

Manganese superoxide dismutase Ala-9Val polymorphism and risk of breast cancer in a population-based case-control study of African Americans and whites.

Journal Article Breast Cancer Res · 2004 INTRODUCTION: A polymorphism in the manganese superoxide dismutase (MnSOD) gene, Ala-9Val, has been examined in association with breast cancer risk in several epidemiologic studies. Results suggest that the Ala allele increases the risk of breast cancer an ... Full text Link to item Cite

Association between non-steroidal anti-inflammatory drugs (NSAIDs) and invasive breast cancer and carcinoma in situ of the breast.

Journal Article Cancer Causes Control · December 2003 OBJECTIVE: Non-steroidal anti-inflammatory drugs (NSAIDs) have been consistently associated with reduced colon cancer risk. Associations with other cancer sites, particularly breast cancer, have been less consistent. This study's objective was to examine t ... Full text Link to item Cite

Antidepressant medications and their association with invasive breast cancer and carcinoma in situ of the breast.

Journal Article Epidemiology · May 2003 BACKGROUND: Experimental studies in animals have suggested that antidepressants may promote the growth of mammary tumors, but epidemiologic data have not shown consistent associations between antidepressant use and breast cancer. METHODS: We analyzed data ... Link to item Cite

Ovulation and ovarian cancer: a comparison of two methods for calculating lifetime ovulatory cycles (United States).

Journal Article Cancer Causes Control · November 2002 OBJECTIVE: To compare two methods for calculating lifetime ovulatory cycles (LOC) to determine if more detailed menstrual cycle information results in stronger associations with ovarian cancer. METHODS: Using data from 232 cases and 242 controls in a popul ... Full text Link to item Cite

Impact of progestin and estrogen potency in oral contraceptives on ovarian cancer risk.

Journal Article J Natl Cancer Inst · January 2, 2002 BACKGROUND: Oral contraceptive (OC) use is associated with a reduced risk of developing ovarian cancer, but the mechanism for the risk reduction has not been well defined. In this study, we investigate the relationship between the progestin and estrogen po ... Full text Link to item Cite

Making epidemiologic studies responsive to the needs of participants and communities: the Carolina Breast Cancer Study experience.

Journal Article Environ Mol Mutagen · 2002 In this report, we present the results of surveys administered to participants and nonparticipants in the Carolina Breast Cancer Study (CBCS). Surveys and structured interviews were administered to determine women's concerns regarding participation in rese ... Full text Link to item Cite

Oral contraceptives and breast cancer among African-american women and white women.

Journal Article J Natl Med Assoc · September 2001 The higher incidence of breast cancer among African-American women younger than 50 as compared to white women points to the need to examine exposures that are common among younger women, including exposure to oral contraceptives (OC). We examined patterns ... Link to item Cite

Prognostic significance of the number of lymph nodes examined in patients with lymph node-negative breast carcinoma.

Journal Article Cancer · June 15, 2001 BACKGROUND: A recent report suggested that the number of lymph nodes examined was a strong predictor of survival in patients with lymph node-negative breast carcinoma. Among women who had >or= 20 lymph nodes examined, the risk of dying from breast carcinom ... Link to item Cite

Vitamin supplement use and breast cancer in a North Carolina population.

Journal Article Public Health Nutr · June 2001 OBJECTIVE: Laboratory data suggest that several different vitamins may inhibit the growth of mammary cancers, however epidemiologic data on the relationship between vitamin supplement use and breast cancer are inconsistent. We examined the association betw ... Full text Link to item Cite

Comparison of two methods for calculating lifetime ovulatory cycles.

Journal Article AMERICAN JOURNAL OF EPIDEMIOLOGY · June 1, 2001 Link to item Cite

Breast cancer: hormones and other risk factors.

Journal Article Maturitas · February 28, 2001 UNLABELLED: In North America and Northern Europe, breast cancer incidence rates begin increasing in the early reproductive years and continue climbing into the late seventies, whereas rates plateau after menopause in japan and less developed countries. Fem ... Full text Link to item Cite

Race, anthropometric factors, and stage at diagnosis of breast cancer.

Journal Article Am J Epidemiol · February 1, 2001 Featured Publication A recent study suggested that the greater prevalence of severe obesity among African-American women explained almost one third of the observed differences between African-American and White women in stage at diagnosis of breast cancer. The objective of thi ... Full text Link to item Cite

Menopausal hormones and breast cancer in a biracial population.

Journal Article Am J Public Health · June 2000 OBJECTIVES: This study examined the association between menopausal hormones and breast cancer in a biracial population. METHODS: Logistic regression was used to calculate odds ratios for breast cancer associated with hormone use among 397 cases and 425 con ... Full text Link to item Cite

Body size and breast cancer risk in black women and white women: the Carolina Breast Cancer Study.

Journal Article Am J Epidemiol · April 15, 2000 The relation between body size and breast cancer risk was investigated in a population-based, case-control study of Black women (350 cases, 353 controls) and White women (523 cases, 471 controls) from North Carolina, aged 20-74 years in 1993-1996. Logistic ... Full text Link to item Cite

Alcohol consumption and breast cancer among black and white women in North Carolina (United States).

Journal Article Cancer Causes Control · April 2000 OBJECTIVE: The purpose of this study was to investigate the effects of alcohol consumption on breast cancer risk in black and white women. METHODS: We used data from the Carolina Breast Cancer Study, a population-based, case-control study of black and whit ... Full text Link to item Cite

Hormone-related factors and risk of breast cancer in relation to estrogen receptor and progesterone receptor status.

Journal Article Am J Epidemiol · April 1, 2000 Risk factors were examined for subgroups of breast cancer characterized by estrogen receptor (ER) and progesterone receptor (PR) status. Data from the Carolina Breast Cancer Study, a population-based, North Carolina case-control study of 862 breast cancer ... Full text Link to item Cite

The associations of adolescent cigarette smoking, alcoholic beverage consumption, environmental tobacco smoke, and ionizing radiation with subsequent breast cancer risk (United States).

Journal Article Cancer Causes Control · March 2000 OBJECTIVES: Studies of breast cancer among survivors of the World War II atomic bomb blasts over Japan suggest that the adolescent breast may be particularly sensitive to carcinogenic insult. To further explore that possibility we examined the relationship ... Full text Link to item Cite

Physical activity at age 12 and adult breast cancer risk (United States).

Journal Article Cancer Causes Control · August 1999 OBJECTIVES: Some epidemiologic studies suggest that adolescent physical activity reduces subsequent breast cancer risk. To examine this question further, we analyzed data on physical activity at age 12 that had been collected as part of the Carolina Breast ... Full text Link to item Cite

Adolescent reproductive events and subsequent breast cancer risk.

Journal Article Am J Public Health · August 1999 OBJECTIVES: This study investigated the relationship between reproductive events during adolescence and subsequent breast cancer risk. METHODS: Logistic regression models used self-reported data from 862 case patients and 790 controls in the Carolina Breas ... Full text Link to item Cite

Lactation and breast cancer risk.

Journal Article Int J Epidemiol · June 1999 BACKGROUND: Data from the Carolina Breast Cancer Study, a population-based, case-control study of breast cancer in African-American and white women residents of North Carolina, were evaluated to determine whether specific aspects of lactation are associate ... Full text Link to item Cite

Participation rates in a case-control study: the impact of age, race, and race of interviewer.

Journal Article Ann Epidemiol · April 1999 Featured Publication PURPOSE: Despite concerns about declining participation rates in epidemiologic studies in recent years, relatively few papers have discussed obstacles to recruiting study participants or strategies for optimizing response rates. This report describes facto ... Full text Link to item Cite

Catechol-O-methyltransferase and breast cancer risk.

Journal Article Carcinogenesis · November 1998 Recent studies suggest that a polymorphism in catechol-O-methyltransferase (COMT) is associated with increased risk of breast cancer. Methylation by COMT is the principal pathway for inactivation of catechol estrogens, which are hypothesized to participate ... Full text Link to item Cite

Age at menarche, time to regular cycling, and breast cancer (North Carolina, United States).

Journal Article Cancer Causes Control · August 1998 OBJECTIVES: Later menarche, and a longer time until onset of regular cycling, are considered markers of lower lifetime exposure to circulating ovarian hormones. While later age at menarche is associated with reduced breast cancer risk, evidence for the rel ... Full text Link to item Cite

Association between high-density lipoprotein cholesterol and breast cancer varies by menopausal status.

Journal Article Cancer Epidemiol Biomarkers Prev · June 1998 A nested case-control study was conducted to investigate the hypothesis that women with high levels of high-density lipoprotein cholesterol (HDL-C) are at an increased risk of breast cancer. The source population was a cohort of 95,000 women enrolled in th ... Link to item Cite

Cigarette smoking, N-acetyltransferases 1 and 2, and breast cancer risk.

Journal Article Cancer Epidemiol Biomarkers Prev · May 1998 To examine the effects of smoking and N-acetylation genetics on breast cancer risk, we analyzed data from an ongoing, population-based, case-control study of invasive breast cancer in North Carolina. The study population consisted of 498 cases and 473 cont ... Link to item Cite

Frequency of breast cancer attributable to BRCA1 in a population-based series of American women.

Journal Article JAMA · March 25, 1998 CONTEXT: Previous studies of BRCA1 mutation prevalence have been based on high-risk groups, yielding estimates that do not reflect the experience of the general population of US patients with breast cancer. OBJECTIVE: To determine prevalence of known disea ... Full text Link to item Cite

Rapid reporting of cancer incidence in a population-based study of breast cancer: one constructive use of a central cancer registry.

Journal Article Breast Cancer Res Treat · July 1995 To support a study of genetic risk factors for breast cancer, the North Carolina Central Cancer Registry has implemented a rapid reporting procedure for hospitals in the study area. This system permits the identification of newly diagnosed breast cancer ca ... Full text Link to item Cite

The Carolina Breast Cancer Study: integrating population-based epidemiology and molecular biology.

Journal Article Breast Cancer Res Treat · July 1995 The integration of epidemiology and molecular biology provides a new strategy to identify additional risk factors for breast cancer and to better understand the role played by traditionally recognized risk factors. The Carolina Breast Cancer Study (CBCS) i ... Full text Link to item Cite

Menopausal hormones and the risk of breast cancer

Journal Article Endocrinologist · January 1, 1992 Menopausal hormone replacement therapy has evolved into a long-term preventive measure because of its notable benefits on osteoporosis and cardiovascular disease. This has raised the concern that prolonged use of hormones may increase the risk of breast ca ... Full text Cite

Socioeconomic status and morbidity and mortality in hypertensive blacks.

Journal Article Cardiovasc Clin · 1991 Despite an overall limited range of social and economic opportunities in the recent past, blacks of lower socioeconomic status have experienced marked excesses in hypertension-related burdens compared with their more advantaged peers: the incidence, preval ... Link to item Cite

Long-term follow-up of patients with advanced ovarian carcinoma treated with debulking surgery and chemotherapy consisting of cisplatin, doxorubicin, and cyclophosphamide. Gynecologic Oncology Group of the Comprehensive Cancer Center.

Journal Article Oncology · 1990 Between June 1980 and December 1984, 88 patients with stage III-IV ovarian carcinoma were entered in a study evaluating the role of debulking surgery and chemotherapy consisting of cyclophosphamide, doxorubicin, and cisplatin intravenously on day 1, every ... Full text Link to item Cite