Journal ArticleOphthalmol Sci · 2025
PURPOSE: To investigate the association between rim area focal hyperautofluorescence (RAFH) signals and geographic atrophy (GA) growth rates, as well as the impact of oral metformin on the longitudinal change of RAFH. DESIGN: Secondary analysis of a random ...
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Journal ArticleBiomedical Optics Express · December 1, 2024
Retinal pigment epithelium (RPE) cells are essential for normal retinal function. Morphological defects in these cells are associated with a number of retinal neurodegenerative diseases. Owing to the cellular ...
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Journal ArticleOcul Surf · August 2, 2024
PURPOSE: To evaluate and compare subbasal corneal nerve parameters of the inferior whorl in patients with dry eye disease (DED), neuropathic corneal pain (NCP), and controls using a novel deep-learning-based algorithm to analyze in-vivo confocal microscopy ...
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Journal ArticleBiomedical optics express · August 2024
Retinal ganglion cells play an important role in human vision, and their degeneration results in glaucoma and other neurodegenerative diseases. Imaging these cells in the living human retina can greatly improve the diagnosis and treatment of glaucoma. Howe ...
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Journal ArticleAging Cell · July 2024
Age and elevated intraocular pressure (IOP) are the two primary risk factors for glaucoma, an optic neuropathy that is the leading cause of irreversible blindness. In most people, IOP is tightly regulated over a lifetime by the conventional outflow tissues ...
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Journal ArticleDiagnostics (Basel, Switzerland) · July 2024
Photoreceptors (PRs) and retinal pigment epithelial (RPE) cells form a functional unit called the PR-RPE complex. The PR-RPE complex plays a critical role in maintaining retinal homeostasis and function, and the quantification of its structure and topograp ...
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Journal ArticleCornea · April 2024
PurposeThe aim of this study was to facilitate deep learning systems in image annotations for diagnosing keratitis type by developing an automated algorithm to classify slit-lamp photographs (SLPs) based on illumination technique.MethodsS ...
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Journal ArticleBiomedical optics express · February 2024
The Editor-in-Chief and Deputy Editor of Biomedical Optics Express announce the prize for the best paper published in the Journal between 2020 and 2022. ...
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Journal ArticleOphthalmol Sci · 2024
PURPOSE: To characterize changes in subfoveal choroidal thickness in preterm infants from 30 to 60 weeks' postmenstrual age (PMA). DESIGN: The prospective, observational Study of Eye Imaging in Preterm infantS (BabySTEPS) enrolled infants eligible for reti ...
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Journal ArticlebioRxiv · December 7, 2023
Age and elevated intraocular pressure (IOP) are the two primary risk factors for glaucoma, an optic neuropathy that is the leading cause of irreversible blindness. In most people, IOP is tightly regulated over a lifetime by the conventional outflow tissues ...
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Journal ArticleCornea · November 2023
PurposeThere is a need to understand physicians' diagnostic uncertainty in the initial management of microbial keratitis (MK). This study aimed to understand corneal specialists' diagnostic uncertainty by establishing risk thresholds for treatment ...
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Journal ArticleCornea · October 2023
PurposeThe aim of this study was to perform automated segmentation of corneal nerves and other structures in corneal confocal microscopy (CCM) images of the subbasal nerve plexus (SNP) in eyes with ocular surface diseases (OSDs).MethodsA ...
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Journal ArticleOphthalmology science · September 2023
PurposeTo develop a fully-automatic hybrid algorithm to jointly segment and quantify biomarkers of polypoidal choroidal vasculopathy (PCV) on indocyanine green angiography (ICGA) and spectral domain-OCT (SD-OCT) images.DesignEvaluation of ...
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Journal ArticleInvestigative ophthalmology & visual science · September 2023
PurposeChoroidal vascular changes occur with normal aging and age-related macular degeneration (AMD). Here, we evaluate choroidal thickness and vascularity in aged rhesus macaques to better understand the choroid's role in this nonhuman primate mo ...
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Journal ArticleProceedings. IEEE Computer Society Conference on Computer Vision and Pattern Recognition · June 2023
Anatomical consistency in biomarker segmentation is crucial for many medical image analysis tasks. A promising paradigm for achieving anatomically consistent segmentation via deep networks is incorporating pixel connectivity, a basic concept in digital top ...
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Journal ArticleIEEE transactions on medical imaging · May 2023
Featured Publication
Optical coherence tomography (OCT) helps ophthalmologists assess macular edema, accumulation of fluids, and lesions at microscopic resolution. Quantification of retinal fluids is necessary for OCT-guided treatment management, which relies on a precise imag ...
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Journal ArticleBiomedical optics express · February 2023
Objective quantification of photoreceptor cell morphology, such as cell diameter and outer segment length, is crucial for early, accurate, and sensitive diagnosis and prognosis of retinal neurodegenerative diseases. Adaptive optics optical coherence tomogr ...
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Journal ArticleBiomedical optics express · February 2023
The Editor-in-Chief and Deputy Editor of Biomedical Optics Express introduce a new prize for the best paper published in the Journal between 2019 and 2021. ...
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ConferenceProgress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2023
Adaptive optics optical coherence tomography (AO-OCT) has allowed for the reliable 3-D imaging of individual retinal cells. The current AO-OCT systems are limited to tabletop implementation due to their size and complexity. This work describes the design a ...
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Journal ArticleAm J Ophthalmol · December 2022
PURPOSE: To investigate baseline mesopic microperimetry (MP) and spectral domain optical coherence tomography (OCT) in the Rate of Progression in USH2A-related Retinal Degeneration (RUSH2A) study. DESIGN: Natural history study METHODS: Setting: 16 clinical ...
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Journal ArticleOphthalmol Retina · November 2022
OBJECTIVE: The purpose of the study was to perform a post hoc analysis to explore the effect of baseline anatomic characteristics identified on OCT on best-corrected visual acuity (BCVA) responses to risuteganib from the completed phase II study in subject ...
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Journal ArticleRetina · July 1, 2022
PURPOSE: To assess the generalizability of a deep learning-based algorithm to segment the ellipsoid zone (EZ). METHODS: The dataset consisted of 127 spectral-domain optical coherence tomography volumes from eyes of participants with USH2A-related retinal d ...
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Journal ArticleOptica · June 20, 2022
Optical coherence tomography (OCT) has seen widespread success as an in vivo clinical diagnostic 3D imaging modality, impacting areas including ophthalmology, cardiology, and gastroenterology. Despite its many advantages, such as high sensitivity, speed, a ...
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Journal ArticleOphthalmol Sci · June 2022
OBJECTIVE: To describe optical coherence tomography (SD-OCT) features, age, gender, and systemic variables that may be used in machine/deep learning studies to identify high-risk patient subpopulations with high risk of progression to geographic atrophy (G ...
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Dataset · April 12, 2022
This repository contains multi-angle volumetric OCT datasets for 3D OCRT reconstruction of four biological samples (zebrafish larva, fruit fly, mouse esophagus, and mouse trachea). The OCT volumes were captured using a custom spectral domain OCT system wit ...
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Journal ArticleThe British journal of ophthalmology · March 2022
AimTo develop a fully automatic algorithm to segment retinal cavitations on optical coherence tomography (OCT) images of macular telangiectasia type 2 (MacTel2).MethodsThe dataset consisted of 99 eyes from 67 participants enrolled in an i ...
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Journal ArticleBiomedical optics express · February 2022
The new Biomedical Optics Express Editor-in-Chief Ruikang (Ricky) Wang and new Deputy Editor Sina Farsiu share their introductory message as they start their editorial terms on 1 January 2022. ...
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Journal ArticleIEEE Transactions on Signal Processing · January 1, 2022
We present a method for learning latent stochastic differential equations (SDEs) from high dimensional time series data. Given a high-dimensional time series generated from a lower dimensional latent unknown Itô process, the proposed method learns the mapp ...
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Journal ArticlePattern recognition · January 2022
Salient object detection (SOD) is viewed as a pixel-wise saliency modeling task by traditional deep learning-based methods. A limitation of current SOD models is insufficient utilization of inter-pixel information, which usually results in imperfect segmen ...
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Journal ArticleExp Eye Res · January 2022
The purpose of this study was to develop an automatic deep learning-based approach and corresponding free, open-source software to perform segmentation of the Schlemm's canal (SC) lumen in optical coherence tomography (OCT) scans of living mouse eyes. A no ...
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ConferenceProceedings of the 38th Conference on Uncertainty in Artificial Intelligence, UAI 2022 · January 1, 2022
We propose a neural network architecture that enables non-parametric calibration and generation of multivariate extreme value distributions (MEVs). MEVs arise from Extreme Value Theory (EVT) as the necessary class of models when extrapolating a distributio ...
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ConferenceProceedings of Machine Learning Research · January 1, 2022
We propose a neural network architecture that enables non-parametric calibration and generation of multivariate extreme value distributions (MEVs). MEVs arise from Extreme Value Theory (EVT) as the necessary class of models when extrapolating a distributio ...
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Journal ArticleJournal of the Optical Society of America A: Optics and Image Science, and Vision · December 1, 2021
Illuminating or imaging samples from a broad angular range is essential in a wide variety of computational 3D imaging and resolution-enhancement techniques, such as optical projection tomography, optical diffraction tomography, synthetic aperture microscop ...
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Journal ArticleJournal of the Optical Society of America A · December 1, 2021
Illuminating or imaging samples from a broad angular range is essential in a wide variety of computational 3D imaging and resolution-enhancement techniques, such as optical projection tomography, optical diffraction tomography, synthetic aperture m ...
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Journal ArticleOptics and Photonics News · November 1, 2021
Combining principles of computed tomography with modern machine-learning tools significantly improves OCT’s resolution while extending imaging depth, reducing noise and reconstructing refractive-index maps of biological samples. Optical coherence tomograph ...
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Journal ArticleBiomedical optics express · October 2021
Optical coherence tomography (OCT) is used for diagnosis of esophageal diseases such as Barrett's esophagus. Given the large volume of OCT data acquired, automated analysis is needed. Here we propose a bilateral connectivity-based neural network for in ...
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Journal ArticleTranslational vision science & technology · October 2021
PurposeTo assess clinical applicability of automatic image analysis in microbial keratitis (MK) by evaluating the relationship between biomarker measurements on slit-lamp photography (SLP) and best-corrected visual acuity (BCVA).MethodsSe ...
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Journal ArticleRetina · August 1, 2021
PURPOSE: To determine the relationship of drusen size as determined by spectral-domain optical coherence tomography (SD-OCT) with that measured on registered color fundus photography (CFP) images and to derive an OCT-based classification system that was co ...
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Journal ArticleNature machine intelligence · July 2021
Fluorescent genetically encoded calcium indicators and two-photon microscopy help understand brain function by generating large-scale in vivo recordings in multiple animal models. Automatic, fast, and accurate active neuron segmentation is critical ...
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Journal ArticleTransl Vis Sci Technol · June 1, 2021
PURPOSE: To investigate the use of imaging modalities in the volumetric measurement of the subretinal space and examine the volume of subretinal blebs created by a subretinal drug delivery device utilizing microscope-integrated optical coherence tomography ...
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Journal ArticleOphthalmol Retina · May 2021
PURPOSE: In macula-wide analyses, spectral-domain (SD) optical coherence tomography (OCT) features including drusen volume, hyperreflective foci, and OCT-reflective drusen substructures independently predict geographic atrophy (GA) onset secondary to age-r ...
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Journal ArticleJAMA Ophthalmol · May 1, 2021
IMPORTANCE: Binocular indirect ophthalmoscopy (BIO) examination for retinopathy of prematurity (ROP) is a well-known cause of repeated preterm infant stress. OBJECTIVE: To compare stress during investigational optical coherence tomography (OCT) imaging to ...
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Journal ArticleOptica · May 2021
Cell-level quantitative features of retinal ganglion cells (GCs) are potentially important biomarkers for improved diagnosis and treatment monitoring of neurodegenerative diseases such as glaucoma, Parkinson's disease, and Alzheimer's disease. Yet, due to ...
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Journal ArticleElife · March 30, 2021
Glucocorticoids are widely used as an ophthalmic medication. A common, sight-threatening adverse event of glucocorticoid usage is ocular hypertension, caused by dysfunction of the conventional outflow pathway. We report that netarsudil, a rho-kinase inhibi ...
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Journal Article · February 17, 2021
We propose a novel neural network architecture that enables non-parametric
calibration and generation of multivariate extreme value distributions (MEVs).
MEVs arise from Extreme Value Theory (EVT) as the necessary class of models
when extrapolating a distr ...
Link to itemCite
Journal ArticleThe British journal of ophthalmology · January 2021
Background/aimsTo quantify retinal cavitation size over time in macular telangiectasia type 2 (MacTel) and to correlate changes with visual acuity and area of ellipsoid zone loss.MethodsOptical coherence tomography (OCT) macula volume sca ...
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Journal ArticleAm J Ophthalmol · January 2021
PURPOSE: Subretinal injections of therapeutics are commonly used to treat ocular diseases. Accurate dosing of therapeutics at target locations is crucial but difficult to achieve using subretinal injections due to leakage, and there is no method available ...
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Journal ArticleAdvances in Optics and Photonics · January 1, 2021
We present a general theory of optical coherence tomography (OCT), which synthesizes the fundamental concepts and implementations of OCT under a common 3D k-space framework. At the heart of this analysis is the Fourier diffraction theorem, which relates th ...
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Journal ArticleIEEE journal of biomedical and health informatics · January 2021
We propose a fully-automatic deep learning-based algorithm for segmentation of ocular structures and microbial keratitis (MK) biomarkers on slit-lamp photography (SLP) images. The dataset consisted of SLP images from 133 eyes with manual annotations by a p ...
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ConferenceProceedings of Machine Learning Research · January 1, 2021
It has been conjectured that the Fisher divergence is more robust to model uncertainty than the conventional Kullback-Leibler (KL) divergence. This motivates the design of a new class of robust generative auto-encoders (AE) referred to as Fisher auto-encod ...
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ConferenceOptics InfoBase Conference Papers · January 1, 2021
We present 3D optical coherence refraction tomography (OCRT), which incoherently synthesizes an extended 3D transfer function using multi-view OCT volumes spanning two angular dimensions. Our setup features a novel use of parabolic mirrors, achieving milli ...
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ConferenceProceedings of the IEEE Computer Society Conference on Computer Vision and Pattern Recognition · January 1, 2021
We present a feature-free photogrammetric technique that enables quantitative 3D mesoscopic (mm-scale height variation) imaging with tens-of-micron accuracy from sequences of images acquired by a smartphone at close range (several cm) under freehand motion ...
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Journal ArticleCVPR 2021 · December 10, 2020
We present a feature-free photogrammetric technique that enables quantitative
3D mesoscopic (mm-scale height variation) imaging with tens-of-micron accuracy
from sequences of images acquired by a smartphone at close range (several cm)
under freehand motion ...
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Journal ArticleCornea · December 2020
PurposeTo evaluate the reliability of manual annotation when quantifying cornea anatomical and microbial keratitis (MK) morphological features on slit-lamp photography (SLP) images.MethodsProspectively enrolled patients with MK underwent ...
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Journal ArticleAm J Ophthalmol · November 2020
PURPOSE: To report baseline visual fields in the Rate of Progression in USH2A-related Retinal Degeneration (RUSH2A) study. DESIGN: Cross-sectional study within a natural history study. METHODS: Setting: multicenter, international. STUDY POPULATION: Usher s ...
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Journal ArticleOpt Lett · September 1, 2020
Non-confocal adaptive optics scanning laser ophthalmoscopy (AOSLO) has enhanced the study of human retinal photoreceptors by providing complementary information to standard confocal AOSLO images. Previously we developed the first confocal handheld AOSLO (H ...
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Journal ArticleFASEB J · August 2020
Lysyl oxidase-like-1 (LOXL1), a vital crosslinking enzyme in elastin fiber maintenance, is essential for the stability and strength of elastic vessels and tissues. Variants in the LOXL1 locus associate with a dramatic increase in risk of exfoliation syndro ...
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Journal ArticleInvestigative ophthalmology & visual science · July 2020
PurposeTo employ quantitative fundus autofluorescence (qAF) imaging in rhesus macaques to noninvasively assess retinal pigment epithelial (RPE) lipofuscin in nonhuman primates (NHPs) as a model of aging and age-related macular degeneration (AMD).< ...
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ConferenceOphthalmology · June 2020
PurposeTo validate the efficacy of a fully automatic, deep learning-based segmentation algorithm beyond conventional performance metrics by measuring the primary outcome of a clinical trial for macular telangiectasia type 2 (MacTel2).Design
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Journal ArticleIEEE transactions on medical imaging · June 2020
Image post-processing is used in clinical-grade ultrasound scanners to improve image quality (e.g., reduce speckle noise and enhance contrast). These post-processing techniques vary across manufacturers and are generally kept proprietary, which presents a ...
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Journal ArticleSci Rep · May 13, 2020
We acquired depth-resolved light scattering measurements from the retinas of triple transgenic Alzheimer's Disease (3xTg-AD) mice and wild type (WT) age-matched controls using co-registered angle-resolved low-coherence interferometry (a/LCI) and optical co ...
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Journal ArticleICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings · May 1, 2020
We develop a framework for estimating unknown partial differential equations (PDEs) from noisy data, using a deep learning approach. Given noisy samples of a solution to an unknown PDE, our method interpolates the samples using a neural network, and extrac ...
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Journal ArticleOptics letters · April 2020
In optical coherence tomography (OCT), the axial resolution is often superior to the lateral resolution, which is sacrificed for long imaging depths. To address this anisotropy, we previously developed optical coherence refraction tomography (OCRT), which ...
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Journal ArticleInvestigative ophthalmology & visual science · March 2020
PurposeTo test whether ganglion cell layer (GCL) and inner plexiform layer (IPL) topography is altered in albinism.MethodsOptical coherence tomography scans were analyzed in 30 participants with albinism and 25 control participants. Horiz ...
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Journal ArticleBiomed Opt Express · February 1, 2020
Anti-vascular endothelial growth factor (VEGF) agents are widely regarded as the first line of therapy for diabetic macular edema (DME) but are not universally effective. An automatic method that can predict whether a patient is likely to respond to anti-V ...
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Journal ArticleTranslational vision science & technology · February 2020
PurposeWe determined the progression of visual function, macular structure, and quality of life in patients with regressed proliferative diabetic retinopathy (PDR) after panretinal photocoagulation (PRP).MethodsIn this prospective study, ...
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Journal ArticleInvestigative ophthalmology & visual science · February 2020
PurposeTo characterize the evolution and structure of soft drusen in aged rhesus macaques using in vivo multimodal retinal imaging and ex vivo histologic and ultrastructural analyses as a nonhuman primate model of early age-related macular degener ...
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ConferenceOptics InfoBase Conference Papers · January 1, 2020
We present a preliminary k-space-based analysis of OCT and our recently proposed extension, optical coherence refraction tomography (OCRT). Our theory provides insight into how angular compounding enhances resolution and reduces speckle in coherence imagin ...
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ConferenceProgress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2020
Quantitative features of individual ganglion cells (GCs) are potential paradigm changing biomarkers for improved diagnosis and treatment monitoring of GC loss in neurodegenerative diseases like glaucoma and Alzheimer's disease. The recent incorporation of ...
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ConferenceProgress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2020
Adaptive optics scanning laser ophthalmoscopy (AOSLO) has advanced the study of retinal structure and function by enabling in vivo imaging of individual photoreceptors. Most implementations of AOSLOs are large, complex tabletop systems, thereby preventing ...
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Journal ArticleBiomedical optics express · December 2019
Large scale simultaneous recording of fast patterns of neural activity remains challenging. Volumetric imaging modalities such as scanning-beam light-sheet microscopy (LSM) and wide-field light-field microscopy (WFLFM) fall short of the goal due to their c ...
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Journal ArticleNature photonics · November 2019
Optical coherence tomography (OCT) is a cross-sectional, micron-scale imaging modality with widespread clinical application. Typical OCT systems sacrifice lateral resolution to achieve long depths of focus for bulk tissue imaging, and hence tend to have be ...
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Journal ArticleNeurophotonics · October 2019
The guest editorial provides an introduction to the Special Section on Advanced Retinal Imaging: Instrumentation, Methods, and Applications. ...
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ConferenceIEEE International Ultrasonics Symposium, IUS · October 1, 2019
Image post-processing is used in clinical-grade ultrasound scanners to improve image quality (e.g., reduce speckle noise and enhance contrast). These post-processing techniques vary across manufacturers and are generally kept proprietary, which presents a ...
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Dataset · September 27, 2019
DukeUltrasound is an ultrasound dataset collected at Duke University with a Verasonics c52v probe. It contains delay-and-sum (DAS) beamformed data as well as data post-processed with Siemens Dynamic TCE for speckle reduction, contrast enhancement and impro ...
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Journal ArticleBiomedical optics express · August 2019
Quantification of the human rod and cone photoreceptor mosaic in adaptive optics scanning light ophthalmoscope (AOSLO) images is useful for the study of various retinal pathologies. Subjective and time-consuming manual grading has remained the gold standar ...
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Journal ArticleInt Ophthalmol · July 2019
PURPOSE: To demonstrate the anatomical development of the human macula using handheld spectral domain optical coherence tomography (SD-OCT) during the first 5 years of life. METHODS: This study is a cross-sectional, observational case series. Thirty-five n ...
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Journal ArticleJ Neurol · July 2019
Alzheimer's disease (AD) and age-related macular degeneration (AMD) are important disorders of aging, but significant challenges remain in diagnosis and therapy. Amyloid-beta (Aβ), found in the brain and a defining feature of AD, has also been observed in ...
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Journal ArticleOphthalmology · April 2019
PURPOSE: To test the effects of an encapsulated cell-based delivery of a neuroprotective agent, ciliary neurotrophic factor (CNTF), on progression of macular telangiectasia type 2, a neurodegenerative disease with no proven effective therapy. DESIGN: Rando ...
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Journal ArticleNature photonics · April 2019
Super-resolution optical microscopy techniques have enabled the discovery and visualization of numerous phenomena in physics, chemistry and biology1-3. However, the highest resolution super-resolution techniques depend on nonlinear fluorescence ...
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Journal ArticleProceedings of the National Academy of Sciences of the United States of America · April 2019
Featured Publication
Calcium imaging records large-scale neuronal activity with cellular resolution in vivo. Automated, fast, and reliable active neuron segmentation is a critical step in the analysis workflow of utilizing neuronal signals in real-time behavioral studies for d ...
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Journal ArticleOphthalmol Retina · April 2019
PURPOSE: Macular atrophy and scar increase in prevalence during treatment for neovascular age-related macular degeneration and are associated with poor visual acuity. We sought to identify the distribution of spectral-domain OCT (SD-OCT)-determined feature ...
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Journal ArticleScientific reports · March 2019
Age-related macular degeneration (AMD) - the leading cause of vision loss in the elderly - share many risks factors as atherosclerosis, which exhibits loss of vascular compliance resulting from aging and oxidative stress. Here, we attempt to explore choroi ...
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Journal ArticleProc Natl Acad Sci U S A · January 29, 2019
Ocular corticosteroids are commonly used clinically. Unfortunately, their administration frequently leads to ocular hypertension, i.e., elevated intraocular pressure (IOP), which, in turn, can progress to a form of glaucoma known as steroid-induced glaucom ...
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Journal ArticleFrontiers in pediatrics · January 2019
Introduction: Anterior lens capsule vascularity (ALCV) is resorbed in the developing fetus from 27 to 35 weeks gestation. In this pilot study, we evaluated the feasibility and validity of combining smartphone ophthalmoscope videos of ALCV and image ...
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Journal ArticlePloS one · January 2019
Although drusen have long been acknowledged as a primary hallmark of dry age-related macular degeneration (AMD) their role in the disease remains unclear. We hypothesize that drusen accumulation increases the barrier to metabolite transport ultimately resu ...
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Journal ArticleHeritage Science · December 1, 2018
Ancient Egyptian mummies were often covered with an outer casing, panels and masks made from cartonnage: a lightweight material made from linen, plaster, and recycled papyrus held together with adhesive. Egyptologists, papyrologists, and historians aim to ...
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Journal ArticleBiomedical optics express · December 2018
Gestational age estimation at time of birth is critical for determining the degree of prematurity of the infant and for administering appropriate postnatal treatment. We present a fully automated algorithm for estimating gestational age of premature infant ...
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Journal ArticleIEEE transactions on bio-medical engineering · November 2018
ObjectiveAlthough optical imaging of neurons using fluorescent genetically encoded calcium sensors has enabled large-scale in vivo experiments, the sensors' slow dynamics often blur closely timed action potentials into indistinguishable transients ...
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Journal ArticleOptica · September 20, 2018
Featured Publication
Adaptive optics scanning laser ophthalmoscopy (AOSLO) has enabled in vivo visualization and enhanced understanding of retinal structure and function. Current generation AOSLOs have a large footprint and are mainly limited to imaging cooperative adult subje ...
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Journal ArticleIEEE transactions on medical imaging · September 2018
Optical coherence tomography (OCT) has revolutionized diagnosis and prognosis of ophthalmic diseases by visualization and measurement of retinal layers. To speed up the quantitative analysis of disease biomarkers, an increasing number of automatic segmenta ...
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Journal ArticleBiomedical optics express · August 2018
Fast and reliable quantification of cone photoreceptors is a bottleneck in the clinical utilization of adaptive optics scanning light ophthalmoscope (AOSLO) systems for the study, diagnosis, and prognosis of retinal diseases. To-date, manual grading has be ...
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Journal ArticleBiomed Opt Express · June 1, 2018
Ophthalmic procedures demand precise surgical instrument control in depth, yet standard operating microscopes supply limited depth perception. Current commercial microscope-integrated optical coherence tomography partially meets this need with manually-pos ...
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Journal ArticleBiomed Opt Express · June 1, 2018
Photoreceptor ellipsoid zone (EZ) defects visible on optical coherence tomography (OCT) are important imaging biomarkers for the onset and progression of macular diseases. As such, accurate quantification of EZ defects is paramount to monitor disease progr ...
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Journal ArticleOphthalmol Retina · May 2018
PURPOSE: To develop methods to make precise comparisons of specific retinal features between and within spectral-domain (SD) OCT images, color fundus photography (CFP) images, and fluorescein angiography (FA) images in eyes treated with anti-vascular endot ...
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Journal ArticleCornea · March 2018
PurposeTo assess variability in corneal ulcer measurements between ophthalmologists and reduce clinician-dependent variability using semiautomated segmentation of the ulcer from photographs.MethodsThree ophthalmologists measured 50 patien ...
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Journal ArticleExperimental eye research · March 2018
Nonhuman primates are important preclinical models of retinal diseases because they uniquely possess a macula similar to humans. Ocular imaging technologies such as spectral-domain optical coherence tomography (SD-OCT) allow noninvasive, in vivo measuremen ...
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Journal ArticleAmerican journal of ophthalmology · February 2018
PurposeTo evaluate choroidal and suprachoroidal changes following suprachoroidal injection of triamcinolone acetonide injectable suspension (CLS-TA), in eyes with macular edema due to retinal vein occlusion (RVO).DesignProspective cohort ...
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Journal ArticlePLoS One · 2018
Inner retina in Alzheimer's Disease (AD) may experience neuroinflammation resulting in atrophy. The objective of our study was to determine whether retinal GCIPL (ganglion cell-inner plexiform layer) or nerve fiber layer (NFL) thickness may serve as noninv ...
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ConferenceIS and T Archiving Conference, ARCHIVING 2018 · January 1, 2018
This rapid development and testing project captured data from multiple digital imaging techniques to try to see texts in papyrus mâché mummy mask cartonnage layers. Prior studies by other scholars destroyed the masks to access the papyri, denying future re ...
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Journal ArticleMolecular vision · January 2018
PurposeTo identify changes induced by environmental tobacco smoke (ETS) in circulatory microRNA (miRNA) in plasma and ocular fluids of the Rhesus macaque and compare these changes to normal age-related changes. Tobacco smoke has been identified as ...
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ConferenceOphthalmology · December 2017
PURPOSE: Appearance of geographic atrophy (GA) on color photography (CP) is preceded by specific features on spectral-domain optical coherence tomography (SD OCT). We aimed to build SD OCT-based risk assessment models for 5-year new onset of GA and central ...
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Journal ArticleAmerican journal of ophthalmology · December 2017
PurposeTo determine if different types of retinal fluid in the central macula affect the reproducibility of choroidal thickness (CT) measurements on enhanced depth imaging optical coherence tomography (EDI-OCT).DesignRetrospective reliabi ...
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Journal ArticleScientific reports · November 2017
Nonhuman primates are the only mammals to possess a true macula similar to humans, and spontaneously develop drusenoid lesions which are hallmarks of age-related macular degeneration (AMD). Prior studies demonstrated similarities between human and nonhuman ...
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Journal ArticleTransl Vis Sci Technol · October 2017
PURPOSE: We determined the feasibility of fovea and optic nerve head imaging with a long working distance (LWD) swept source optical coherence tomography (OCT) prototype in adults, teenagers, and young children. METHODS: A prototype swept source OCT system ...
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Journal ArticleBiomed Opt Express · September 1, 2017
Age-related macular degeneration (AMD) is a major cause of vision loss in the elderly. To better study the pathobiology of AMD, postmortem eyes offer an excellent opportunity to correlate optical coherence tomography (OCT) imaging characteristics with hist ...
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Journal ArticleScientific reports · July 2017
Imaging with an adaptive optics scanning light ophthalmoscope (AOSLO) enables direct visualization of the cone photoreceptor mosaic in the living human retina. Quantitative analysis of AOSLO images typically requires manual grading, which is time consuming ...
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Journal ArticleJ Comp Neurol · June 1, 2017
Müller glia, the most abundant glia of vertebrate retina, have an elaborate morphology characterized by a vertical stalk that spans the retina and branches in each retinal layer. Müller glia play diverse, critical roles in retinal homeostasis, which are pr ...
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Journal ArticleBiomedical optics express · May 2017
We present a novel framework combining convolutional neural networks (CNN) and graph search methods (termed as CNN-GS) for the automatic segmentation of nine layer boundaries on retinal optical coherence tomography (OCT) images. CNN-GS first utilizes a CNN ...
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Journal ArticleInvest Ophthalmol Vis Sci · May 1, 2017
PURPOSE: To correlate ellipsoid zone (EZ) defects on spectral-domain optical coherence tomography (SD-OCT) with retinal sensitivity loss on macular integrity assessment (MAIA) microperimetry in macular telangiectasia type 2 (MacTel). METHODS: Macular SD-OC ...
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Journal ArticleTransl Vis Sci Technol · March 2017
PURPOSE: We use semiautomated segmentation of fluorescein angiography (FA) to determine whether anti-vascular endothelial growth factor (VEGF) treatment for diabetic macular edema (DME) differentially affects microaneurysm (MA)-associated leakage, termed f ...
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Journal ArticleTransl Vis Sci Technol · February 2017
PURPOSE: We determine whether the automated segmentation software, Duke Optical Coherence Tomography Retinal Analysis Program (DOCTRAP), can measure, in a platform-independent manner, retinal thickness on Cirrus and Spectralis spectral domain optical coher ...
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Journal ArticleIEEE transactions on medical imaging · February 2017
We demonstrate the usefulness of utilizing a segmentation step for improving the performance of sparsity based image reconstruction algorithms. In specific, we will focus on retinal optical coherence tomography (OCT) reconstruction and propose a novel segm ...
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Journal ArticleOpt Lett · January 1, 2017
Optical coherence tomography angiography (OCTA) is a promising technique for non-invasive visualization of vessel networks in the human eye. We debut a system capable of acquiring wide field-of-view (>70°) OCT angiograms without mosaicking. Additionally, w ...
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Journal ArticleBiomed Opt Express · January 1, 2017
The peripheral retina of the human eye offers a unique opportunity for assessment and monitoring of ocular diseases. We have developed a novel wide-field (>70°) optical coherence tomography system (WF-OCT) equipped with wavefront sensorless adaptive optics ...
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Journal ArticleOpen Ophthalmol J · 2017
BACKGROUND: The diagnosis of plus disease in retinopathy of prematurity (ROP) largely determines the need for treatment; however, this diagnosis is subjective. To make the diagnosis of plus disease more objective, semi-automated computer programs (e.g. ROP ...
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Chapter · January 1, 2017
The image processing algorithms collectively known as super-resolution have proven effective in producing high-quality imagery from a collection of low-resolution photographic images. In this chapter, we examine some of the advantages and challenges of app ...
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Journal ArticleOphthalmology · December 2016
PURPOSE: Structural and compositional heterogeneity within drusen comprising lipids, carbohydrates, and proteins have been previously described. We sought to detect and define phenotypic patterns of drusen heterogeneity in the form of optical coherence tom ...
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Journal ArticleOphthalmology · December 2016
PURPOSE: Structural and compositional heterogeneity within drusen comprising lipids, carbohydrates, and proteins have been previously described. We sought to detect and define phenotypic patterns of drusen heterogeneity in the form of optical coherence tom ...
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Journal ArticleBiomed Opt Express · December 1, 2016
Patient motion artifacts are often visible in densely sampled or large wide field-of-view (FOV) retinal optical coherence tomography (OCT) volumes. A popular strategy for reducing motion artifacts is to capture two orthogonally oriented volumetric scans. H ...
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Journal ArticleCornea · November 2016
PURPOSE: To examine big-bubble (BB) formation success rates in deep anterior lamellar keratoplasty (DALK) at various corneal depths using real-time guidance from swept-source, microscope-integrated optical coherence tomography (SS-MIOCT). METHODS: The DALK ...
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Journal ArticleOptometry and vision science : official publication of the American Academy of Optometry · November 2016
PurposeSpectral domain optical coherence tomography (SD-OCT) imaging permits in vivo visualization of the choroid with micron-level resolution over wide areas and is of interest for studies of ocular growth and myopia control. We evaluated the spe ...
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Journal ArticleInvestigative ophthalmology & visual science · October 2016
PurposeTo compare cross-sectional choroidal morphology in rhesus macaque and human eyes using enhanced-depth imaging optical coherence tomography (EDI-OCT) and histologic analysis.MethodsEnhanced-depth imaging-OCT images from 25 rhesus ma ...
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Journal ArticleEur J Pharmacol · September 15, 2016
Visual impairment due to glaucoma currently impacts 70 million people worldwide. While disease progression can be slowed or stopped with effective lowering of intraocular pressure, current medical treatments are often inadequate. Fortunately, three new cla ...
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Journal ArticleAmerican journal of ophthalmology · September 2016
PurposeTo assess the reliability of manual choroidal thickness measurements by comparing different posterior boundary definitions of the choroidal-scleral junction on enhanced depth imaging optical coherence tomography (EDI-OCT).DesignRel ...
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Journal ArticleSci Rep · August 19, 2016
Minimally-invasive microsurgery has resulted in improved outcomes for patients. However, operating through a microscope limits depth perception and fixes the visual perspective, which result in a steep learning curve to achieve microsurgical proficiency. W ...
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Journal ArticleScientific reports · July 2016
Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disorder that may have anterior visual pathway involvement. In this study, we compare the macular structure of patients with ALS to healthy controls, and examine correlations between macula ...
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Journal ArticleInvest Ophthalmol Vis Sci · July 1, 2016
PURPOSE: Posterior eye shape assessment by magnetic resonance imaging (MRI) is used to study myopia. We tested the hypothesis that optical coherence tomography (OCT), as an alternative, could measure posterior eye shape similarly to MRI. METHODS: Macular s ...
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Journal ArticleInvest Ophthalmol Vis Sci · July 1, 2016
PURPOSE: The integration of swept-source optical coherence tomography (SS-OCT) into the operating microscope enables real-time, tissue-level three-dimensional (3D) imaging to aid in ophthalmic microsurgery. In this prospective randomized controlled study, ...
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Journal ArticleInvest Ophthalmol Vis Sci · July 1, 2016
PURPOSE: To determine whether longitudinal changes in mesopic visual function on microperimetry occurred independent of its associations with microstructural parameters on spectral-domain optical coherence tomography (SD-OCT) in the early stages of AMD. ME ...
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Journal ArticleJ Biomed Opt · July 1, 2016
We introduce a metric in graph search and demonstrate its application for segmenting retinal optical coherence tomography (OCT) images of macular pathology. Our proposed “adjusted mean arc length” (AMAL) metric is an adaptation of the lowest mean arc lengt ...
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Journal ArticleEye (London, England) · June 2016
PurposeTo quantify early neuroretinal alterations in patients with type 1 diabetes mellitus (T1DM) and to assess whether glycemic variability contributes to alterations in neuroretinal structure or function.MethodsThirty patients with T1DM and 51 controls ...
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Journal ArticleAm J Ophthalmol · May 2016
PURPOSE: To evaluate relationships between age-related macular degeneration (AMD) morphology on spectral-domain optical coherence tomography (SDOCT) and visual function. DESIGN: Cross-sectional, observational. METHODS: From the Alabama Study on Early AMD b ...
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Journal ArticleBiomedical optics express · May 2016
Quantitative analysis of the cone photoreceptor mosaic in the living retina is potentially useful for early diagnosis and prognosis of many ocular diseases. Non-confocal split detector based adaptive optics scanning light ophthalmoscope (AOSLO) imaging rev ...
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Journal ArticleBiomed Opt Express · April 1, 2016
Angle-resolved low coherence interferometry (a/LCI) is an optical technique used to measure nuclear morphology in situ. However, a/LCI is not an imaging modality and can produce ambiguous results when the measurements are not properly oriented to the tissu ...
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Journal ArticleInvest Ophthalmol Vis Sci · April 1, 2016
PURPOSE: To develop image analysis software usable by nonexpert graders to segment geographic atrophy (GA) from dry AMD and to quantify rim area focal hyperautofluorescence (RAFH) surrounding GA on fundus autofluorescence (FAF) images. To compare the GA pr ...
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Journal ArticleOphthalmology · January 2016
PURPOSE: To analyze the value of novel measures of retinal pigment epithelium-drusen complex (RPEDC) volume to predict 2-year disease progression of intermediate age-related macular degeneration (AMD). DESIGN: Prospective, observational study. PARTICIPANTS ...
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Journal ArticleInvestigative ophthalmology & visual science · January 2016
PurposeThe pathophysiology of vision loss in persons with diabetic retinopathy (DR) is complex and incompletely defined. We hypothesized that retinal pigment epithelium (RPE) and rod and cone photoreceptor dysfunction, as measured by dark adaptome ...
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Journal ArticleAlzheimer's & dementia (Amsterdam, Netherlands) · January 2016
IntroductionRetinal structural changes in subjects with mild cognitive impairment (MCI) remain a subject of controversy.MethodsWe investigated the correlation between optical coherence tomography (OCT) of the retinal sublayers, including ...
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Journal ArticleIEEE Trans Med Imaging · December 2015
We propose a novel, graph-theoretic framework for distinguishing arteries from veins in a fundus image. We make use of the underlying vessel topology to better classify small and midsized vessels. We extend our previously proposed tree topology estimation ...
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Journal ArticleInvest Ophthalmol Vis Sci · December 2015
PURPOSE: Mice are commonly used to study conventional outflow physiology. This study examined how physical factors (hydration, temperature, and anterior chamber [AC] deepening) influence ocular perfusion measurements in mice. METHODS: Outflow facility (C) ...
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Journal ArticleIEEE Transactions on Pattern Analysis and Machine Intelligence · August 1, 2015
Featured Publication
Tree-like structures are fundamental in nature, and it is often useful to reconstruct the topology of a tree-what connects to what-from a two-dimensional image of it. However, the projected branches often cross in the image: the tree projects to a planar g ...
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Journal ArticleRetina · August 2015
PURPOSE: To report the intraoperative optical coherence tomography findings in idiopathic epiretinal membrane (ERM) with connecting strands and to describe the postoperative outcomes. METHODS: A retrospective, case series study within a prospective observa ...
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Journal ArticleTransl Vis Sci Technol · July 2015
PURPOSE: To characterize the first in-human intraoperative imaging using a custom prototype spectral-domain microscope-integrated optical coherence tomography (MIOCT) device during vitreoretinal surgery with instruments in the eye. METHODS: Under instituti ...
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Journal ArticleJ Neuroophthalmol · June 2015
BACKGROUND: To apply automated spectral domain optical coherence tomography (SD-OCT) segmentation to eyes with resolving papilledema. METHODS: Ninety-four patients with idiopathic intracranial hypertension seen at the Duke Eye Center neuro-ophthalmology cl ...
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Journal ArticleAm J Ophthalmol · April 2015
PURPOSE: To compare choroidal thickness in patients with intermediate or advanced age-related macular degeneration (AMD) and control subjects using enhanced-depth imaging optical coherence tomography (EDI-OCT). DESIGN: Retrospective cross-sectional study o ...
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Journal ArticleAm J Ophthalmol · April 2015
PURPOSE: To measure average retinal nerve fiber layer (RNFL) thicknesses in healthy, full-term neonates. DESIGN: Descriptive research to develop normative data. METHODS: Healthy infants born between 37 and 42 weeks postmenstrual age were imaged with hand-h ...
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Journal ArticleBiomed Opt Express · April 1, 2015
We present a fully automatic algorithm to identify fluid-filled regions and seven retinal layers on spectral domain optical coherence tomography images of eyes with diabetic macular edema (DME). To achieve this, we developed a kernel regression (KR)-based ...
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Journal ArticleInvest Ophthalmol Vis Sci · January 29, 2015
PURPOSE: To create and validate software to automatically segment leakage area in real-world clinical fluorescein angiography (FA) images of subjects with diabetic macular edema (DME). METHODS: Fluorescein angiography images obtained from 24 eyes of 24 sub ...
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Journal ArticleBiomedical optics express · September 2014
Scanning laser ophthalmoscopes (SLOs) are able to achieve superior contrast and axial sectioning capability compared to fundus photography. However, SLOs typically use monochromatic illumination and are thus unable to extract color information of the retin ...
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Journal ArticleOptics letters · July 2014
The effective speed of a swept source optical coherence tomography (SSOCT) imaging system was quadrupled using efficient sweep buffering along with coherence revival and spatial multiplexing. A polarizing beam splitter and fold mirror assembly were used to ...
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Journal ArticleInvest Ophthalmol Vis Sci · March 4, 2014
PURPOSE: The goal was to assess effects of IOP and pilocarpine-induced ciliary muscle contraction on conventional outflow pathway tissues in living anesthetized mice. METHODS: Intraocular pressure was controlled by intracameral cannulation of mouse eyes wh ...
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Journal ArticleOpt Lett · March 1, 2014
Featured Publication
We report on an algorithm for fast wavefront sensing that incorporates sparse representation for the first time in practice. The partial derivatives of optical wavefronts were sampled sparsely with a Shack-Hartman wavefront sensor (SHWFS) by randomly subsa ...
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Journal ArticleJAMA Ophthalmol · February 2014
IMPORTANCE: Accurate measurements of choroidal thickness (CT) using enhanced-depth imaging optical coherence tomography (EDI-OCT) require a well-defined choroid-scleral junction (CSJ), which may appear in some eyes as a hyporeflective band corresponding to ...
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Journal ArticleBiomed Opt Express · February 1, 2014
Accurate quantification of retinal layer thicknesses in mice as seen on optical coherence tomography (OCT) is crucial for the study of numerous ocular and neurological diseases. However, manual segmentation is time-consuming and subjective. Previous attemp ...
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Journal ArticleJ Biomed Opt · January 2014
We assessed the reproducibility of lateral and axial measurements performed with spectral-domain optical coherence tomography (SDOCT) instruments from a single manufacturer and across several manufacturers. One human retina phantom was imaged on two instru ...
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Journal ArticleMol Vis · 2014
PURPOSE: The goal of the present study was to test for the first time whether glaucomatous-like disease progression in a mouse can be assessed morphologically and functionally with spectral domain optical coherence tomography (SD-OCT). METHODS: We monitore ...
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Journal ArticleInvest Ophthalmol Vis Sci · December 13, 2013
Age-related macular degeneration is the leading cause of irreversible visual dysfunction in individuals over 65 in Western Society. Patients with AMD are classified as having early stage disease (early AMD), in which visual function is affected, or late AM ...
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Journal ArticleInvest Ophthalmol Vis Sci · November 15, 2013
PURPOSE: To determine whether a novel automatic segmentation program, the Duke Optical Coherence Tomography Retinal Analysis Program (DOCTRAP), can be applied to spectral-domain optical coherence tomography (SD-OCT) images obtained from different commercia ...
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Journal ArticleIEEE Trans Med Imaging · November 2013
Featured Publication
In this paper, we present a novel technique, based on compressive sensing principles, for reconstruction and enhancement of multi-dimensional image data. Our method is a major improvement and generalization of the multi-scale sparsity based tomographic den ...
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Journal ArticleJournal of biomedical optics · July 2013
Confocal scanning laser ophthalmoscopy (cSLO) enables high-resolution and high-contrast imaging of the retina by employing spatial filtering for scattered light rejection. However, to obtain optimized image quality, one must design the cSLO around scanner ...
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Journal ArticleInvest Ophthalmol Vis Sci · June 14, 2013
PURPOSE: To determine whether choroidal imaging is feasible in preterm and term infants using an 840-nm portable spectral domain optical coherence tomography (SD-OCT) system without the use of enhanced-depth imaging techniques and to assess choroidal devel ...
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Journal ArticleBiomed Opt Express · June 1, 2013
Geometrical analysis of the photoreceptor mosaic can reveal subclinical ocular pathologies. In this paper, we describe a fully automatic algorithm to identify and segment photoreceptors in adaptive optics ophthalmoscope images of the photoreceptor mosaic. ...
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Journal ArticleBiomedical optics express · June 2013
Variance processing methods in Fourier domain optical coherence tomography (FD-OCT) have enabled depth-resolved visualization of the capillary beds in the retina due to the development of imaging systems capable of acquiring A-scan data in the 100 kHz regi ...
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Journal ArticleBiomedical optics express · January 2013
Scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) are widely used retinal imaging modalities that can assist in the diagnosis of retinal pathologies. The combination of SLO and OCT provides a more comprehensive imaging system and a ...
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Journal ArticleOphthalmic Surg Lasers Imaging Retina · 2013
BACKGROUND AND OBJECTIVE: To enhance understanding of ethnically diverse normal newborn retinal morphology, the authors report spectral-domain optical coherence tomography (SD-OCT) macular findings in healthy Hispanic newborns. PATIENTS AND METHODS: In thi ...
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ConferenceDigital Holography and Three-Dimensional Imaging, DH 2012 · December 1, 2012
We report on a preliminary study comparing corneal refractive power acquired using distributed scanning OCT (DSOCT) to corneal topography and Scheimpflug photography in normal subjects both before and after refractive surgery. ...
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Journal ArticleBiomed Opt Express · September 1, 2012
We present a method, termed distributed scanning OCT (DSOCT), which reduces the effects of patient motion on corneal biometry utilizing current-generation clinically available spectral domain optical coherence tomography (SDOCT) systems. We first performed ...
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Journal ArticleInvest Ophthalmol Vis Sci · July 9, 2012
PURPOSE: Macular hyperpigmentation is associated with progression from intermediate to advanced age-related macular degeneration (AMD). The purpose of this study was to accurately correlate hyperpigmentary changes with spectral domain optical coherence tom ...
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Journal ArticleThe British journal of ophthalmology · July 2012
BackgroundVascularisation of the macula takes place between 24 and 27 weeks post-conception. Preterm birth may affect the formation of the foveal avascular zone (FAZ) and foveal depression, and displacement of inner retinal layers away from the in ...
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Journal ArticleBiomed Opt Express · June 1, 2012
We present a comparison of corneal biometric values from dense volumetric spectral domain optical coherence tomography (SDOCT) scans to reference values in both phantoms and clinical subjects. We also present a new optically based "keratometric equivalent ...
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Journal ArticleBiomed Opt Express · May 1, 2012
In this paper, we make contact with the field of compressive sensing and present a development and generalization of tools and results for reconstructing irregularly sampled tomographic data. In particular, we focus on denoising Spectral-Domain Optical Coh ...
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Journal ArticleBiomed Opt Express · May 1, 2012
This paper presents a generalized framework for segmenting closed-contour anatomical and pathological features using graph theory and dynamic programming (GTDP). More specifically, the GTDP method previously developed for quantifying retinal and corneal la ...
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Journal ArticleInvest Ophthalmol Vis Sci · April 6, 2012
PURPOSE: This study was conducted to determine whether there were significant differences in choroidal thickness, contrast, outer choroidal vessel (OCV), and choroidal-scleral junction (CSJ) visualization in inverted versus upright spectral-domain optical ...
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Journal ArticleBiomed Opt Express · February 1, 2012
We present a methodology for extracting the vascular network in the human retina using Dijkstra's shortest-path algorithm. Our method preserves vessel thickness, requires no manual intervention, and follows vessel branching naturally and efficiently. To te ...
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Journal ArticleInvest Ophthalmol Vis Sci · January 5, 2012
PURPOSE: To automatically segment retinal spectral domain optical coherence tomography (SD-OCT) images of eyes with age-related macular degeneration (AMD) and various levels of image quality to advance the study of retinal pigment epithelium (RPE)+drusen c ...
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Journal ArticleOphthalmology · December 2011
PURPOSE: To determine the dynamic morphologic development of the human fovea in vivo using portable spectral domain-optical coherence tomography (SD-OCT). DESIGN: Prospective, observational case series. PARTICIPANTS: Thirty-one prematurely born neonates, 9 ...
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Journal ArticleArch Ophthalmol · November 2011
Optimal management of optic pit-related maculopathy remains to be determined. The fluid source for the maculopathy also remains controversial. In this article, we present a unique surgical technique for internal drainage of the intraretinal fluid and descr ...
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Journal ArticleBiomed Opt Express · October 1, 2011
Indirect ophthalmoscopy (IO) is the standard of care for evaluation of the neonatal retina. When recorded on video from a head-mounted camera, IO images have low quality and narrow Field of View (FOV). We present an image fusion methodology for converting ...
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Journal ArticleProc Natl Acad Sci U S A · July 12, 2011
Age-related macular degeneration (AMD) is a leading cause of visual dysfunction worldwide. Amyloid β (Aβ) peptides, Aβ1-40 (Aβ40) and Aβ1-42 (Aβ42), have been implicated previously in the AMD disease process. Consistent with a pathogenic role for Aβ, we sh ...
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Journal ArticleBiomed Opt Express · June 1, 2011
Segmentation of anatomical structures in corneal images is crucial for the diagnosis and study of anterior segment diseases. However, manual segmentation is a time-consuming and subjective process. This paper presents an automatic approach for segmenting c ...
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Journal ArticleInvest Ophthalmol Vis Sci · May 16, 2011
PURPOSE: To demonstrate an operating microscope-mounted spectral domain optical coherence tomography (MMOCT) system for human retinal and model surgery imaging. METHODS: A prototype MMOCT system was developed to interface directly with an ophthalmic surgic ...
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Journal ArticleMol Cell Proteomics · March 2011
The retina is a highly ordered tissue whose outermost layers are formed by subcellular compartments of photoreceptors generating light-evoked electrical responses. We studied protein distributions among individual photoreceptor compartments by separating t ...
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Journal ArticleInvest Ophthalmol Vis Sci · December 2010
PURPOSE: To identify and evaluate the use of contrast agents in optical coherence tomography (OCT) for ophthalmic applications. METHODS: Three agents-prednisolone acetate (PA), triamcinolone acetonide (TA), and lipid-based artificial tears (LBAT)-were test ...
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Chapter · December 1, 2010
We describe an efficient approach for the automated segmentation of pathological/morphological structures in ophthalmic Spectral Domain Optical Coherence Tomography (SDOCT) images. In this algorithm, image pixels are treated as nodes of a graph with edge w ...
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Journal ArticleInvest Ophthalmol Vis Sci · October 2010
PURPOSE: Spectral domain-optical coherence tomography (SD-OCT) may be useful for efficient measurement of drusen in patients with age-related macular degeneration (AMD). Areas identified as drusen from semiautomated segmentation of drusen on SD-OCT were co ...
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Journal ArticleIEEE Trans Image Process · October 2010
Featured Publication
Super-resolution (SR) is the process of combining multiple aliased low-quality images to produce a high-resolution high-quality image. Aside from registration and fusion of low-resolution images, a key process in SR is the restoration and denoising of the ...
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Journal ArticleOpt Express · August 30, 2010
Segmentation of anatomical and pathological structures in ophthalmic images is crucial for the diagnosis and study of ocular diseases. However, manual segmentation is often a time-consuming and subjective process. This paper presents an automatic approach ...
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Journal ArticleBiomedical optics express · August 2010
Scanning laser ophthalmoscopy (SLO) and spectral domain optical coherence tomography (SDOCT) have become essential clinical diagnostic tools in ophthalmology by allowing for video-rate noninvasive en face and depth-resolved visualization of retinal structu ...
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Journal ArticleOphthalmology · December 2009
PURPOSE: To elucidate the subclinical anatomy of retinopathy of prematurity (ROP) using spectral domain optical coherence tomography (SD OCT). DESIGN: Prospective, observational case series. PARTICIPANTS: Three low-birth-weight, severely premature infants. ...
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Journal ArticleConference Record - Asilomar Conference on Signals, Systems and Computers · December 1, 2009
Fast and accurate estimation of the Fourier transform in polar coordinates has long been a major challenge for many image processing applications including phase-correlation based motion estimation. To address this problem, it has been proposed to calculat ...
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Journal ArticleIEEE Transactions on Components and Packaging Technologies · August 14, 2009
In this paper, we present a new technique to calculate the power dissipation profile from the IC temperature map using a process analogous to image processing and restoration. In this technique, finite-element analysis (FEA) is used to find the heat-point ...
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Journal ArticleOphthalmology · March 2009
PURPOSE: Detect changes in the neurosensory retina using spectral-domain optical coherence tomography (SD OCT) imaging over drusen in age-related macular degeneration (AMD). Quantitative imaging biomarkers may aid in defining risk of disease progression. D ...
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Journal ArticleAm J Ophthalmol · February 2009
PURPOSE: To evaluate and treat infant retina through the use of a hand-held spectral-domain optical coherence tomography (SD OCT) device in selected cases of Shaken Baby syndrome (SBS). DESIGN: Observational case series. METHODS: A novel SD OCT system was ...
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Journal ArticleArch Ophthalmol · January 2009
OBJECTIVES: To evaluate the spectrum of foveal architecture in pediatric albinism and to assess the utility of spectral-domain optical coherence tomography (OCT) in ocular imaging of children with nystagmus. METHODS: Spectral-domain OCT imaging was perform ...
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Journal ArticleRetina · 2009
PURPOSE: To describe the intraoperative use of handheld spectral domain optical coherence tomography (SDOCT) imaging in macular surgery. DESIGN: Prospective, observational case series. METHODS: A handheld SDOCT device was used to obtain preincision optical ...
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Journal ArticleComputer Journal · January 1, 2009
Accurate registration of images is the most important and challenging aspect of multiframe image restoration problems such as super-resolution. The accuracy of super-resolution algorithms is quite often limited by the ability to register a set of low-resol ...
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Chapter · December 1, 2008
Our previous work demonstrates the ability to reconstruct a single higher resolution image from fusing a collection of multiple extremely low-dosage aliased X-ray images. While this computationally efficient method eliminates aliasing artifacts associated ...
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Chapter · May 26, 2008
Accurate detection-characterization of drusen is an important imaging biomarker of age-related macular degeneration (AMD) progression. We report on the development of an automatic method for detection and segmentation of drusen in retinal images captured v ...
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Journal ArticleIEEE transactions on image processing : a publication of the IEEE Signal Processing Society · April 2008
Kernel regression is an effective tool for a variety of image processing tasks such as denoising and interpolation [1]. In this paper, we extend the use of kernel regression for deblurring applications. In some earlier examples in the literature, such nonp ...
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Chapter · January 1, 2008
Single-sensor imaging provides a convenient, yet low-cost solution for the problem of capturing color images at multiple wavelengths. To capture color, single-sensor cameras add a color filter array (CFA) [1], [2] on top of the photo-detector array. The CF ...
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OtherConference Record - Asilomar Conference on Signals, Systems and Computers · December 1, 2007
Multiframe image reconstruction produces images beyond the native resolution of a digital image sensor by way of accurate sub-pixel registration of aliased images. We present a novel multiframe registration approach for the purpose of enhancing resolution ...
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Journal ArticleProceedings of SPIE - The International Society for Optical Engineering · August 31, 2007
Bilateral filtering1,2 has proven to be a powerful tool for adaptive denoising purposes. Unlike conventional filters, the bilateral filter defines the closeness of two pixels not only based on geometric distance but also based on radiometric (graylevel) di ...
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Journal ArticleAnnual IEEE Semiconductor Thermal Measurement and Management Symposium · August 27, 2007
In this paper, we present a new technique to calculate the power dissipation profile from the IC temperature map using an analogy with image processing and restoration. In this technique, finite element analysis (FEA) is used to find the heat point spread ...
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Journal ArticleAppl Opt · August 10, 2007
We exploit recent advances in active high-resolution imaging through scattering media with ballistic photons. We derive the fundamental limits on the accuracy of the estimated parameters of a mathematical model that describes such an imaging scenario and c ...
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Journal ArticleIEEE transactions on image processing : a publication of the IEEE Signal Processing Society · February 2007
In this paper, we make contact with the field of nonparametric statistics and present a development and generalization of tools and results for use in image processing and reconstruction. In particular, we adapt and expand kernel regression ideas for use i ...
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Journal ArticleProceedings - International Conference on Image Processing, ICIP · December 1, 2006
We introduce a class of robust non-parametric estimation methods which are ideally suited for the reconstruction of signals and images from noise-corrupted or sparsely collected samples. The filters derived from this class are locally adapted kernels which ...
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Journal ArticleProceedings - International Conference on Image Processing, ICIP · December 1, 2006
We exploit recent advances in the physical design of fast optical systems which enable active imaging with "ballistic" light. In this modality, fast bursts of optical energy are propagated into a medium, and the ballistic component of light (which travels ...
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Journal ArticleConference Record - Asilomar Conference on Signals, Systems and Computers · December 1, 2006
The framework of kernel regression [1], a non-parametric estimation method, has been widely used in different guises for solving a variety of image processing problems including denoising and interpolation [2]. In this paper, we extend the use of kernel re ...
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Journal ArticleProceedings of SPIE - The International Society for Optical Engineering · May 1, 2006
Theoretical and practical limitations usually constrain the achievable resolution of any imaging device. Super-Resolution (SR) methods are developed through the years to go beyond this limit by acquiring and fusing several low-resolution (LR) images of the ...
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Journal ArticleEurasip Journal on Applied Signal Processing · April 19, 2006
We address the dynamic super-resolution (SR) problem ofreconstructing a high-quality set of monochromatic or colorsuper-resolved images from low-quality monochromatic, color, ormosaiced frames. Our approach includes a joint method forsimultaneous SR, deblu ...
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Journal ArticleIEEE Trans Image Process · January 2006
In the last two decades, two related categories of problems have been studied independently in image restoration literature: super-resolution and demosaicing. A closer look at these problems reveals the relation between them, and, as conventional color dig ...
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Journal ArticleConference Record - Asilomar Conference on Signals, Systems and Computers · December 1, 2005
This paper introduces an extremely robust adaptive denoising filter in the spatial domain. The filter is based on non-parametric statistical estimation methods, and in particular generalizes an adaptive method proposed earlier by Fukunaga [1]. To denoise a ...
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Journal ArticleIEEE Workshop on Statistical Signal Processing Proceedings · January 1, 2005
We address the problem of estimating the relative motion between the frames of a video sequence. In comparison with the commonly applied pairwise image registration methods, we consider global consistency conditions for the overall multi-frame motion estim ...
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Journal ArticleProceedings of SPIE - The International Society for Optical Engineering · December 1, 2004
In the last two decades a variety of super-resolution (SR) methods have been proposed. These methods usually address the problem of fusing a set of monochromatic images to produce a single monochromatic image with higher spatial resolution. In this paper w ...
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Journal ArticleProceedings of SPIE - The International Society for Optical Engineering · December 1, 2004
In the last two decades, two related categories of problems have been studied independently in the image restoration literature: super-resolution and demosaicing. A closer look at these problems reveals the relation between them, and as conventional color ...
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Journal ArticleIEEE transactions on image processing : a publication of the IEEE Signal Processing Society · October 2004
Featured Publication
Super-resolution reconstruction produces one or a set of high-resolution images from a set of low-resolution images. In the last two decades, a variety of super-resolution methods have been proposed. These methods are usually very sensitive to their assume ...
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Journal ArticleInternational Journal of Imaging Systems and Technology · September 27, 2004
Super-Resolution reconstruction produces one or a set of high-resolution images from a sequence of low-resolution frames. This article reviews a variety of Super-Resolution methods proposed in the last 20 years, and provides some insight into, and a summar ...
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Journal ArticleIEEE International Conference on Image Processing · December 17, 2003
In the last two decades, many papers have been published, proposing a variety methods of multi-frame resolution enhancement. These methods are usually very sensitive to their assumed model of data and noise, which limits their utility. This paper reviews s ...
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Journal ArticleProceedings of SPIE - The International Society for Optical Engineering · December 1, 2003
In the last two decades, many papers have been published, proposing a variety of methods for multi-frame resolution enhancement. These methods, which have a wide range of complexity, memory and time requirements, are usually very sensitive to their assumed ...
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Journal ArticleLupus · January 2002
Artificial neural networks are intelligent systems that have been successfully used for prediction in different medical fields. In this study, efficiency of neural networks for prediction of lupus nephritis in patients with systemic lupus erythematosus (SL ...
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