Scholars@Duke
Sina Farsiu

Sina Farsiu

Anderson-Rupp Professor of Biomedical Engineering
Biomedical Engineering
Box 3802 Med Ctr, Durham, NC 27710
CIEMAS 2575, Durham, NC 27708

Selected Publications

Association of Hyperautofluorescence Signals with Geographic Atrophy Progression in the METformin for the MINimization of Geographic Atrophy Progression Trial.

Journal Article Ophthalmol Sci · 2025 PURPOSE: To investigate the association between rim area focal hyperautofluorescence (RAFH) signals and geographic atrophy (GA) growth rates, as well as the impact of oral metformin on the longitudinal change of RAFH. DESIGN: Secondary analysis of a random ... Full text Link to item Cite

Identifying retinal pigment epithelium cells in adaptive optics-optical coherence tomography images with partial annotations and superhuman accuracy

Journal Article Biomedical Optics Express · December 1, 2024 Retinal pigment epithelium (RPE) cells are essential for normal retinal function. Morphological defects in these cells are associated with a number of retinal neurodegenerative diseases. Owing to the cellular ... Full text Cite

Deep-learning based analysis of in-vivo confocal microscopy images of the subbasal corneal nerve plexus' inferior whorl in patients with neuropathic corneal pain and dry eye disease.

Journal Article Ocul Surf · August 2, 2024 PURPOSE: To evaluate and compare subbasal corneal nerve parameters of the inferior whorl in patients with dry eye disease (DED), neuropathic corneal pain (NCP), and controls using a novel deep-learning-based algorithm to analyze in-vivo confocal microscopy ... Full text Link to item Cite

In vivo imaging of human retinal ganglion cells using optical coherence tomography without adaptive optics.

Journal Article Biomedical optics express · August 2024 Retinal ganglion cells play an important role in human vision, and their degeneration results in glaucoma and other neurodegenerative diseases. Imaging these cells in the living human retina can greatly improve the diagnosis and treatment of glaucoma. Howe ... Full text Cite

Aging and intraocular pressure homeostasis in mice.

Journal Article Aging Cell · July 2024 Age and elevated intraocular pressure (IOP) are the two primary risk factors for glaucoma, an optic neuropathy that is the leading cause of irreversible blindness. In most people, IOP is tightly regulated over a lifetime by the conventional outflow tissues ... Full text Link to item Cite

Quantification of Human Photoreceptor-Retinal Pigment Epithelium Macular Topography with Adaptive Optics-Optical Coherence Tomography.

Journal Article Diagnostics (Basel, Switzerland) · July 2024 Photoreceptors (PRs) and retinal pigment epithelial (RPE) cells form a functional unit called the PR-RPE complex. The PR-RPE complex plays a critical role in maintaining retinal homeostasis and function, and the quantification of its structure and topograp ... Full text Cite

Automatic Classification of Slit-Lamp Photographs by Imaging Illumination.

Journal Article Cornea · April 2024 PurposeThe aim of this study was to facilitate deep learning systems in image annotations for diagnosing keratitis type by developing an automated algorithm to classify slit-lamp photographs (SLPs) based on illumination technique.MethodsS ... Full text Cite

Biomedical Optics Express recognizes the 2023 best paper prize winners: editorial.

Journal Article Biomedical optics express · February 2024 The Editor-in-Chief and Deputy Editor of Biomedical Optics Express announce the prize for the best paper published in the Journal between 2020 and 2022. ... Full text Cite

Longitudinal Choroidal Development in Preterm Infants.

Journal Article Ophthalmol Sci · 2024 PURPOSE: To characterize changes in subfoveal choroidal thickness in preterm infants from 30 to 60 weeks' postmenstrual age (PMA). DESIGN: The prospective, observational Study of Eye Imaging in Preterm infantS (BabySTEPS) enrolled infants eligible for reti ... Full text Link to item Cite

Aging and intraocular pressure homeostasis in mice.

Journal Article bioRxiv · December 7, 2023 Age and elevated intraocular pressure (IOP) are the two primary risk factors for glaucoma, an optic neuropathy that is the leading cause of irreversible blindness. In most people, IOP is tightly regulated over a lifetime by the conventional outflow tissues ... Full text Link to item Cite

Quantifying Clinicians' Diagnostic Uncertainty When Making Initial Treatment Decisions for Microbial Keratitis.

Journal Article Cornea · November 2023 PurposeThere is a need to understand physicians' diagnostic uncertainty in the initial management of microbial keratitis (MK). This study aimed to understand corneal specialists' diagnostic uncertainty by establishing risk thresholds for treatment ... Full text Cite

Open-Source Automated Segmentation of Neuronal Structures in Corneal Confocal Microscopy Images of the Subbasal Nerve Plexus With Accuracy on Par With Human Segmentation.

Journal Article Cornea · October 2023 PurposeThe aim of this study was to perform automated segmentation of corneal nerves and other structures in corneal confocal microscopy (CCM) images of the subbasal nerve plexus (SNP) in eyes with ocular surface diseases (OSDs).MethodsA ... Full text Cite

Joint Multimodal Deep Learning-based Automatic Segmentation of Indocyanine Green Angiography and OCT Images for Assessment of Polypoidal Choroidal Vasculopathy Biomarkers.

Journal Article Ophthalmology science · September 2023 PurposeTo develop a fully-automatic hybrid algorithm to jointly segment and quantify biomarkers of polypoidal choroidal vasculopathy (PCV) on indocyanine green angiography (ICGA) and spectral domain-OCT (SD-OCT) images.DesignEvaluation of ... Full text Cite

Choroidal Changes in Rhesus Macaques in Aging and Age-Related Drusen.

Journal Article Investigative ophthalmology & visual science · September 2023 PurposeChoroidal vascular changes occur with normal aging and age-related macular degeneration (AMD). Here, we evaluate choroidal thickness and vascularity in aged rhesus macaques to better understand the choroid's role in this nonhuman primate mo ... Full text Cite

Directional Connectivity-based Segmentation of Medical Images.

Journal Article Proceedings. IEEE Computer Society Conference on Computer Vision and Pattern Recognition · June 2023 Anatomical consistency in biomarker segmentation is crucial for many medical image analysis tasks. A promising paradigm for achieving anatomically consistent segmentation via deep networks is incorporating pixel connectivity, a basic concept in digital top ... Full text Cite

RetiFluidNet: A Self-Adaptive and Multi-Attention Deep Convolutional Network for Retinal OCT Fluid Segmentation.

Journal Article IEEE transactions on medical imaging · May 2023 Featured Publication Optical coherence tomography (OCT) helps ophthalmologists assess macular edema, accumulation of fluids, and lesions at microscopic resolution. Quantification of retinal fluids is necessary for OCT-guided treatment management, which relies on a precise imag ... Full text Cite

Deep learning-enabled volumetric cone photoreceptor segmentation in adaptive optics optical coherence tomography images of normal and diseased eyes.

Journal Article Biomedical optics express · February 2023 Objective quantification of photoreceptor cell morphology, such as cell diameter and outer segment length, is crucial for early, accurate, and sensitive diagnosis and prognosis of retinal neurodegenerative diseases. Adaptive optics optical coherence tomogr ... Full text Cite

Biomedical Optics Express recognizes the best paper prize winners: editorial.

Journal Article Biomedical optics express · February 2023 The Editor-in-Chief and Deputy Editor of Biomedical Optics Express introduce a new prize for the best paper published in the Journal between 2019 and 2021. ... Full text Cite

Dual modality handheld adaptive optics optical coherence tomography probe for in vivo 3-D photoreceptor imaging

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2023 Adaptive optics optical coherence tomography (AO-OCT) has allowed for the reliable 3-D imaging of individual retinal cells. The current AO-OCT systems are limited to tabletop implementation due to their size and complexity. This work describes the design a ... Full text Cite

Baseline Microperimetry and OCT in the RUSH2A Study: Structure-Function Association and Correlation With Disease Severity.

Journal Article Am J Ophthalmol · December 2022 PURPOSE: To investigate baseline mesopic microperimetry (MP) and spectral domain optical coherence tomography (OCT) in the Rate of Progression in USH2A-related Retinal Degeneration (RUSH2A) study. DESIGN: Natural history study METHODS: Setting: 16 clinical ... Full text Link to item Cite

Impact of Baseline Quantitative OCT Features on Response to Risuteganib for the Treatment of Dry Age-Related Macular Degeneration: The Importance of Outer Retinal Integrity.

Journal Article Ophthalmol Retina · November 2022 OBJECTIVE: The purpose of the study was to perform a post hoc analysis to explore the effect of baseline anatomic characteristics identified on OCT on best-corrected visual acuity (BCVA) responses to risuteganib from the completed phase II study in subject ... Full text Link to item Cite

VALIDATION OF A DEEP LEARNING-BASED ALGORITHM FOR SEGMENTATION OF THE ELLIPSOID ZONE ON OPTICAL COHERENCE TOMOGRAPHY IMAGES OF AN USH2A-RELATED RETINAL DEGENERATION CLINICAL TRIAL.

Journal Article Retina · July 1, 2022 PURPOSE: To assess the generalizability of a deep learning-based algorithm to segment the ellipsoid zone (EZ). METHODS: The dataset consisted of 127 spectral-domain optical coherence tomography volumes from eyes of participants with USH2A-related retinal d ... Full text Link to item Cite

Computational 3D microscopy with optical coherence refraction tomography.

Journal Article Optica · June 20, 2022 Optical coherence tomography (OCT) has seen widespread success as an in vivo clinical diagnostic 3D imaging modality, impacting areas including ophthalmology, cardiology, and gastroenterology. Despite its many advantages, such as high sensitivity, speed, a ... Full text Link to item Cite

Machine learning OCT predictors of progression from intermediate age-related macular degeneration to geographic atrophy and vision loss.

Journal Article Ophthalmol Sci · June 2022 OBJECTIVE: To describe optical coherence tomography (SD-OCT) features, age, gender, and systemic variables that may be used in machine/deep learning studies to identify high-risk patient subpopulations with high risk of progression to geographic atrophy (G ... Full text Link to item Cite

Data from: Computational 3D microscopy with optical coherence refraction tomography

Dataset · April 12, 2022 This repository contains multi-angle volumetric OCT datasets for 3D OCRT reconstruction of four biological samples (zebrafish larva, fruit fly, mouse esophagus, and mouse trachea). The OCT volumes were captured using a custom spectral domain OCT system wit ... Full text Cite

Deep learning-based classification and segmentation of retinal cavitations on optical coherence tomography images of macular telangiectasia type 2.

Journal Article The British journal of ophthalmology · March 2022 AimTo develop a fully automatic algorithm to segment retinal cavitations on optical coherence tomography (OCT) images of macular telangiectasia type 2 (MacTel2).MethodsThe dataset consisted of 99 eyes from 67 participants enrolled in an i ... Full text Cite

Editorial from the New Editor-in-Chief and the New Deputy Editor.

Journal Article Biomedical optics express · February 2022 The new Biomedical Optics Express Editor-in-Chief Ruikang (Ricky) Wang and new Deputy Editor Sina Farsiu share their introductory message as they start their editorial terms on 1 January 2022. ... Full text Cite

Identifying Latent Stochastic Differential Equations

Journal Article IEEE Transactions on Signal Processing · January 1, 2022 We present a method for learning latent stochastic differential equations (SDEs) from high dimensional time series data. Given a high-dimensional time series generated from a lower dimensional latent unknown Itô process, the proposed method learns the mapp ... Full text Cite

BiconNet: An Edge-preserved Connectivity-based Approach for Salient Object Detection.

Journal Article Pattern recognition · January 2022 Salient object detection (SOD) is viewed as a pixel-wise saliency modeling task by traditional deep learning-based methods. A limitation of current SOD models is insufficient utilization of inter-pixel information, which usually results in imperfect segmen ... Full text Cite

Open-source deep learning-based automatic segmentation of mouse Schlemm's canal in optical coherence tomography images.

Journal Article Exp Eye Res · January 2022 The purpose of this study was to develop an automatic deep learning-based approach and corresponding free, open-source software to perform segmentation of the Schlemm's canal (SC) lumen in optical coherence tomography (OCT) scans of living mouse eyes. A no ... Full text Link to item Cite

Modeling Extremes with d-max-decreasing Neural Networks

Conference Proceedings of the 38th Conference on Uncertainty in Artificial Intelligence, UAI 2022 · January 1, 2022 We propose a neural network architecture that enables non-parametric calibration and generation of multivariate extreme value distributions (MEVs). MEVs arise from Extreme Value Theory (EVT) as the necessary class of models when extrapolating a distributio ... Cite

Modeling Extremes with d-max-decreasing Neural Networks

Conference Proceedings of Machine Learning Research · January 1, 2022 We propose a neural network architecture that enables non-parametric calibration and generation of multivariate extreme value distributions (MEVs). MEVs arise from Extreme Value Theory (EVT) as the necessary class of models when extrapolating a distributio ... Cite

High-speed multiview imaging approaching 4pi steradians using conic section mirrors: Theoretical and practical considerations

Journal Article Journal of the Optical Society of America A: Optics and Image Science, and Vision · December 1, 2021 Illuminating or imaging samples from a broad angular range is essential in a wide variety of computational 3D imaging and resolution-enhancement techniques, such as optical projection tomography, optical diffraction tomography, synthetic aperture microscop ... Full text Cite

High-speed multiview imaging approaching 4pi steradians using conic section mirrors: theoretical and practical considerations

Journal Article Journal of the Optical Society of America A · December 1, 2021 Illuminating or imaging samples from a broad angular range is essential in a wide variety of computational 3D imaging and resolution-enhancement techniques, such as optical projection tomography, optical diffraction tomography, synthetic aperture m ... Full text Cite

Optical Coherence Refraction Tomography

Journal Article Optics and Photonics News · November 1, 2021 Combining principles of computed tomography with modern machine-learning tools significantly improves OCT’s resolution while extending imaging depth, reducing noise and reconstructing refractive-index maps of biological samples. Optical coherence tomograph ... Full text Cite

Connectivity-based deep learning approach for segmentation of the epithelium in in vivo human esophageal OCT images.

Journal Article Biomedical optics express · October 2021 Optical coherence tomography (OCT) is used for diagnosis of esophageal diseases such as Barrett's esophagus. Given the large volume of OCT data acquired, automated analysis is needed. Here we propose a bilateral connectivity-based neural network for in ... Full text Cite

Open-Source Automatic Biomarker Measurement on Slit-Lamp Photography to Estimate Visual Acuity in Microbial Keratitis.

Journal Article Translational vision science & technology · October 2021 PurposeTo assess clinical applicability of automatic image analysis in microbial keratitis (MK) by evaluating the relationship between biomarker measurements on slit-lamp photography (SLP) and best-corrected visual acuity (BCVA).MethodsSe ... Full text Cite

COMPARISON OF SINGLE DRUSEN SIZE ON COLOR FUNDUS PHOTOGRAPHY AND SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY.

Journal Article Retina · August 1, 2021 PURPOSE: To determine the relationship of drusen size as determined by spectral-domain optical coherence tomography (SD-OCT) with that measured on registered color fundus photography (CFP) images and to derive an OCT-based classification system that was co ... Full text Link to item Cite

Segmentation of Neurons from Fluorescence Calcium Recordings Beyond Real-time.

Journal Article Nature machine intelligence · July 2021 Fluorescent genetically encoded calcium indicators and two-photon microscopy help understand brain function by generating large-scale in vivo recordings in multiple animal models. Automatic, fast, and accurate active neuron segmentation is critical ... Full text Cite

Microscope-Integrated OCT-Guided Volumetric Measurements of Subretinal Blebs Created by a Suprachoroidal Approach.

Journal Article Translational vision science & technology · June 2021 PurposeTo investigate the use of imaging modalities in the volumetric measurement of the subretinal space and examine the volume of subretinal blebs created by a subretinal drug delivery device utilizing microscope-integrated optical coherence tom ... Full text Cite

Local Anatomic Precursors to New-Onset Geographic Atrophy in Age-Related Macular Degeneration as Defined on OCT.

Journal Article Ophthalmol Retina · May 2021 PURPOSE: In macula-wide analyses, spectral-domain (SD) optical coherence tomography (OCT) features including drusen volume, hyperreflective foci, and OCT-reflective drusen substructures independently predict geographic atrophy (GA) onset secondary to age-r ... Full text Link to item Cite

Preterm Infant Stress During Handheld Optical Coherence Tomography vs Binocular Indirect Ophthalmoscopy Examination for Retinopathy of Prematurity.

Journal Article JAMA Ophthalmol · May 1, 2021 IMPORTANCE: Binocular indirect ophthalmoscopy (BIO) examination for retinopathy of prematurity (ROP) is a well-known cause of repeated preterm infant stress. OBJECTIVE: To compare stress during investigational optical coherence tomography (OCT) imaging to ... Full text Link to item Cite

Weakly supervised individual ganglion cell segmentation from adaptive optics OCT images for glaucomatous damage assessment.

Journal Article Optica · May 2021 Cell-level quantitative features of retinal ganglion cells (GCs) are potentially important biomarkers for improved diagnosis and treatment monitoring of neurodegenerative diseases such as glaucoma, Parkinson's disease, and Alzheimer's disease. Yet, due to ... Full text Cite

Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis.

Journal Article Elife · March 30, 2021 Glucocorticoids are widely used as an ophthalmic medication. A common, sight-threatening adverse event of glucocorticoid usage is ocular hypertension, caused by dysfunction of the conventional outflow pathway. We report that netarsudil, a rho-kinase inhibi ... Full text Link to item Cite

Modeling Extremes with d-max-decreasing Neural Networks

Journal Article · February 17, 2021 We propose a novel neural network architecture that enables non-parametric calibration and generation of multivariate extreme value distributions (MEVs). MEVs arise from Extreme Value Theory (EVT) as the necessary class of models when extrapolating a distr ... Link to item Cite

Intraoperative Retinal Changes May Predict Surgical Outcomes After Epiretinal Membrane Peeling.

Journal Article Translational vision science & technology · February 2021 PurposeTo investigate whether intraoperative retinal changes during epiretinal membrane (ERM) peeling affect anatomic or functional outcomes after surgery.MethodsWe measured retinal thickness using an intraoperative optical coherence tomo ... Full text Cite

Retinal cavitations in macular telangiectasia type 2 (MacTel): longitudinal structure-function correlations.

Journal Article The British journal of ophthalmology · January 2021 Background/aimsTo quantify retinal cavitation size over time in macular telangiectasia type 2 (MacTel) and to correlate changes with visual acuity and area of ellipsoid zone loss.MethodsOptical coherence tomography (OCT) macula volume sca ... Full text Cite

Lightweight Learning-Based Automatic Segmentation of Subretinal Blebs on Microscope-Integrated Optical Coherence Tomography Images.

Journal Article Am J Ophthalmol · January 2021 PURPOSE: Subretinal injections of therapeutics are commonly used to treat ocular diseases. Accurate dosing of therapeutics at target locations is crucial but difficult to achieve using subretinal injections due to leakage, and there is no method available ... Full text Link to item Cite

Fisher Auto-Encoders

Journal Article 24TH INTERNATIONAL CONFERENCE ON ARTIFICIAL INTELLIGENCE AND STATISTICS (AISTATS) · 2021 Cite

Unified k-space theory of optical coherence tomography

Journal Article Advances in Optics and Photonics · January 1, 2021 We present a general theory of optical coherence tomography (OCT), which synthesizes the fundamental concepts and implementations of OCT under a common 3D k-space framework. At the heart of this analysis is the Fourier diffraction theorem, which relates th ... Full text Cite

Open-Source Automatic Segmentation of Ocular Structures and Biomarkers of Microbial Keratitis on Slit-Lamp Photography Images Using Deep Learning.

Journal Article IEEE journal of biomedical and health informatics · January 2021 We propose a fully-automatic deep learning-based algorithm for segmentation of ocular structures and microbial keratitis (MK) biomarkers on slit-lamp photography (SLP) images. The dataset consisted of SLP images from 133 eyes with manual annotations by a p ... Full text Cite

Fisher Auto-Encoders

Conference Proceedings of Machine Learning Research · January 1, 2021 It has been conjectured that the Fisher divergence is more robust to model uncertainty than the conventional Kullback-Leibler (KL) divergence. This motivates the design of a new class of robust generative auto-encoders (AE) referred to as Fisher auto-encod ... Cite

Intraoperative Retinal Changes May Predict Surgical Outcomes After Epiretinal Membrane Peeling

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2021 Cite

The RUSH2A study: Baseline microperimetry and SD-OCT measures

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2021 Cite

Effects of phenylephrine on proximal and distal conventional outflow vessels in living animals

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2021 Cite

Incoherent 3D k-space synthesis with volumetric optical coherence refraction tomography

Conference Optics InfoBase Conference Papers · January 1, 2021 We present 3D optical coherence refraction tomography (OCRT), which incoherently synthesizes an extended 3D transfer function using multi-view OCT volumes spanning two angular dimensions. Our setup features a novel use of parabolic mirrors, achieving milli ... Cite

Mesoscopic photogrammetry with an unstabilized phone camera

Conference Proceedings of the IEEE Computer Society Conference on Computer Vision and Pattern Recognition · January 1, 2021 We present a feature-free photogrammetric technique that enables quantitative 3D mesoscopic (mm-scale height variation) imaging with tens-of-micron accuracy from sequences of images acquired by a smartphone at close range (several cm) under freehand motion ... Full text Cite

Mesoscopic photogrammetry with an unstabilized phone camera

Journal Article CVPR 2021 · December 10, 2020 We present a feature-free photogrammetric technique that enables quantitative 3D mesoscopic (mm-scale height variation) imaging with tens-of-micron accuracy from sequences of images acquired by a smartphone at close range (several cm) under freehand motion ... Open Access Link to item Cite

Measurement Reliability for Keratitis Morphology.

Journal Article Cornea · December 2020 PurposeTo evaluate the reliability of manual annotation when quantifying cornea anatomical and microbial keratitis (MK) morphological features on slit-lamp photography (SLP) images.MethodsProspectively enrolled patients with MK underwent ... Full text Cite

Baseline Visual Field Findings in the RUSH2A Study: Associated Factors and Correlation With Other Measures of Disease Severity.

Journal Article Am J Ophthalmol · November 2020 PURPOSE: To report baseline visual fields in the Rate of Progression in USH2A-related Retinal Degeneration (RUSH2A) study. DESIGN: Cross-sectional study within a natural history study. METHODS: Setting: multicenter, international. STUDY POPULATION: Usher s ... Full text Open Access Link to item Cite

Multimodal handheld adaptive optics scanning laser ophthalmoscope.

Journal Article Opt Lett · September 1, 2020 Non-confocal adaptive optics scanning laser ophthalmoscopy (AOSLO) has enhanced the study of human retinal photoreceptors by providing complementary information to standard confocal AOSLO images. Previously we developed the first confocal handheld AOSLO (H ... Full text Link to item Cite

Integral role for lysyl oxidase-like-1 in conventional outflow tissue function and behavior.

Journal Article FASEB J · August 2020 Lysyl oxidase-like-1 (LOXL1), a vital crosslinking enzyme in elastin fiber maintenance, is essential for the stability and strength of elastic vessels and tissues. Variants in the LOXL1 locus associate with a dramatic increase in risk of exfoliation syndro ... Full text Link to item Cite

Quantitative Fundus Autofluorescence in Rhesus Macaques in Aging and Age-Related Drusen.

Journal Article Investigative ophthalmology & visual science · July 2020 PurposeTo employ quantitative fundus autofluorescence (qAF) imaging in rhesus macaques to noninvasively assess retinal pigment epithelial (RPE) lipofuscin in nonhuman primates (NHPs) as a model of aging and age-related macular degeneration (AMD).< ... Full text Cite

Beyond Performance Metrics: Automatic Deep Learning Retinal OCT Analysis Reproduces Clinical Trial Outcome.

Conference Ophthalmology · June 2020 PurposeTo validate the efficacy of a fully automatic, deep learning-based segmentation algorithm beyond conventional performance metrics by measuring the primary outcome of a clinical trial for macular telangiectasia type 2 (MacTel2).Design Full text Cite

MimickNet, Mimicking Clinical Image Post- Processing Under Black-Box Constraints.

Journal Article IEEE transactions on medical imaging · June 2020 Image post-processing is used in clinical-grade ultrasound scanners to improve image quality (e.g., reduce speckle noise and enhance contrast). These post-processing techniques vary across manufacturers and are generally kept proprietary, which presents a ... Full text Cite

Effects of aging on conventional outflow anatomy and physiology in C57BL/6 mice

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 2020 Link to item Cite

Multimodal Coherent Imaging of Retinal Biomarkers of Alzheimer's Disease in a Mouse Model.

Journal Article Sci Rep · May 13, 2020 We acquired depth-resolved light scattering measurements from the retinas of triple transgenic Alzheimer's Disease (3xTg-AD) mice and wild type (WT) age-matched controls using co-registered angle-resolved low-coherence interferometry (a/LCI) and optical co ... Full text Link to item Cite

Learning Partial Differential Equations from Data Using Neural Networks

Journal Article ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings · May 1, 2020 We develop a framework for estimating unknown partial differential equations (PDEs) from noisy data, using a deep learning approach. Given noisy samples of a solution to an unknown PDE, our method interpolates the samples using a neural network, and extrac ... Full text Cite

Spectroscopic optical coherence refraction tomography.

Journal Article Optics letters · April 2020 In optical coherence tomography (OCT), the axial resolution is often superior to the lateral resolution, which is sacrificed for long imaging depths. To address this anisotropy, we previously developed optical coherence refraction tomography (OCRT), which ... Full text Cite

Assessing Ganglion Cell Layer Topography in Human Albinism Using Optical Coherence Tomography.

Journal Article Investigative ophthalmology & visual science · March 2020 PurposeTo test whether ganglion cell layer (GCL) and inner plexiform layer (IPL) topography is altered in albinism.MethodsOptical coherence tomography scans were analyzed in 30 participants with albinism and 25 control participants. Horiz ... Full text Cite

Deep learning-based single-shot prediction of differential effects of anti-VEGF treatment in patients with diabetic macular edema.

Journal Article Biomed Opt Express · February 1, 2020 Anti-vascular endothelial growth factor (VEGF) agents are widely regarded as the first line of therapy for diabetic macular edema (DME) but are not universally effective. An automatic method that can predict whether a patient is likely to respond to anti-V ... Full text Link to item Cite

Treated PDR Reveals Age-Appropriate Vision Deterioration But Distorted Retinal Organization.

Journal Article Translational vision science & technology · February 2020 PurposeWe determined the progression of visual function, macular structure, and quality of life in patients with regressed proliferative diabetic retinopathy (PDR) after panretinal photocoagulation (PRP).MethodsIn this prospective study, ... Full text Cite

Long-term Evolution and Remodeling of Soft Drusen in Rhesus Macaques.

Journal Article Investigative ophthalmology & visual science · February 2020 PurposeTo characterize the evolution and structure of soft drusen in aged rhesus macaques using in vivo multimodal retinal imaging and ex vivo histologic and ultrastructural analyses as a nonhuman primate model of early age-related macular degener ... Full text Cite

Effects of aging on conventional outflow anatomy and physiology in C57BL/6 mice

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

Resolution enhancement and speckle reduction in coherence imaging: A k-space model of optical coherence refraction tomography (OCRT)

Conference Optics InfoBase Conference Papers · January 1, 2020 We present a preliminary k-space-based analysis of OCT and our recently proposed extension, optical coherence refraction tomography (OCRT). Our theory provides insight into how angular compounding enhances resolution and reduces speckle in coherence imagin ... Cite

Fully automatic quantification of individual ganglion cells from AO-OCT volumes via weakly supervised learning

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2020 Quantitative features of individual ganglion cells (GCs) are potential paradigm changing biomarkers for improved diagnosis and treatment monitoring of GC loss in neurodegenerative diseases like glaucoma and Alzheimer's disease. The recent incorporation of ... Full text Cite

Wavefront sensorless multimodal handheld adaptive optics scanning laser ophthalmoscope for in vivo imaging of human retinal cones

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2020 Adaptive optics scanning laser ophthalmoscopy (AOSLO) has advanced the study of retinal structure and function by enabling in vivo imaging of individual photoreceptors. Most implementations of AOSLOs are large, complex tabletop systems, thereby preventing ... Full text Cite

Mouse corneal transplant evaluation with topography and pachymetry using OCT

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

Meta-learning approach to automatically register multivendor retinal images

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

Deep learning-based automatic segmentation of retinal cavitations on OCT images of MacTel2

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

Hybrid light-sheet and light-field microscope for high resolution and large volume neuroimaging.

Journal Article Biomedical optics express · December 2019 Large scale simultaneous recording of fast patterns of neural activity remains challenging. Volumetric imaging modalities such as scanning-beam light-sheet microscopy (LSM) and wide-field light-field microscopy (WFLFM) fall short of the goal due to their c ... Full text Cite

Optical coherence refraction tomography.

Journal Article Nature photonics · November 2019 Optical coherence tomography (OCT) is a cross-sectional, micron-scale imaging modality with widespread clinical application. Typical OCT systems sacrifice lateral resolution to achieve long depths of focus for bulk tissue imaging, and hence tend to have be ... Full text Cite

Special Section Guest Editorial: Advances in Retinal Imaging.

Journal Article Neurophotonics · October 2019 The guest editorial provides an introduction to the Special Section on Advanced Retinal Imaging: Instrumentation, Methods, and Applications. ... Full text Cite

MimickNet, Matching Clinical Post-Processing under Realistic Black-Box Constraints

Conference IEEE International Ultrasonics Symposium, IUS · October 1, 2019 Image post-processing is used in clinical-grade ultrasound scanners to improve image quality (e.g., reduce speckle noise and enhance contrast). These post-processing techniques vary across manufacturers and are generally kept proprietary, which presents a ... Full text Cite

UltraDuke Version 1

Dataset · September 27, 2019 DukeUltrasound is an ultrasound dataset collected at Duke University with a Verasonics c52v probe. It contains delay-and-sum (DAS) beamformed data as well as data post-processed with Siemens Dynamic TCE for speckle reduction, contrast enhancement and impro ... Full text Cite

RAC-CNN: multimodal deep learning based automatic detection and classification of rod and cone photoreceptors in adaptive optics scanning light ophthalmoscope images.

Journal Article Biomedical optics express · August 2019 Quantification of the human rod and cone photoreceptor mosaic in adaptive optics scanning light ophthalmoscope (AOSLO) images is useful for the study of various retinal pathologies. Subjective and time-consuming manual grading has remained the gold standar ... Full text Cite

Demonstration of anatomical development of the human macula within the first 5 years of life using handheld OCT.

Journal Article Int Ophthalmol · July 2019 PURPOSE: To demonstrate the anatomical development of the human macula using handheld spectral domain optical coherence tomography (SD-OCT) during the first 5 years of life. METHODS: This study is a cross-sectional, observational case series. Thirty-five n ... Full text Link to item Cite

Ocular amyloid imaging at the crossroad of Alzheimer's disease and age-related macular degeneration: implications for diagnosis and therapy.

Journal Article J Neurol · July 2019 Alzheimer's disease (AD) and age-related macular degeneration (AMD) are important disorders of aging, but significant challenges remain in diagnosis and therapy. Amyloid-beta (Aβ), found in the brain and a defining feature of AD, has also been observed in ... Full text Link to item Cite

In vivo measurement of TM stiffness: proof-of-principle in mice

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2019 Link to item Cite

Choroidal Thickness in Myopic Children in the BLINK Study

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2019 Link to item Cite

Reliability of physicians' measurements when manually annotating images of microbial keratitis

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2019 Link to item Cite

Effect of Ciliary Neurotrophic Factor on Retinal Neurodegeneration in Patients with Macular Telangiectasia Type 2: A Randomized Clinical Trial.

Journal Article Ophthalmology · April 2019 PURPOSE: To test the effects of an encapsulated cell-based delivery of a neuroprotective agent, ciliary neurotrophic factor (CNTF), on progression of macular telangiectasia type 2, a neurodegenerative disease with no proven effective therapy. DESIGN: Rando ... Full text Link to item Cite

Super-resolution retinal imaging using optically reassigned scanning laser ophthalmoscopy.

Journal Article Nature photonics · April 2019 Super-resolution optical microscopy techniques have enabled the discovery and visualization of numerous phenomena in physics, chemistry and biology1-3. However, the highest resolution super-resolution techniques depend on nonlinear fluorescence ... Full text Cite

Fast and robust active neuron segmentation in two-photon calcium imaging using spatiotemporal deep learning.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · April 2019 Featured Publication Calcium imaging records large-scale neuronal activity with cellular resolution in vivo. Automated, fast, and reliable active neuron segmentation is a critical step in the analysis workflow of utilizing neuronal signals in real-time behavioral studies for d ... Full text Cite

Distribution of OCT Features within Areas of Macular Atrophy or Scar after 2 Years of Anti-VEGF Treatment for Neovascular AMD in CATT.

Journal Article Ophthalmol Retina · April 2019 PURPOSE: Macular atrophy and scar increase in prevalence during treatment for neovascular age-related macular degeneration and are associated with poor visual acuity. We sought to identify the distribution of spectral-domain OCT (SD-OCT)-determined feature ... Full text Link to item Cite

Vascular Response to Sildenafil Citrate in Aging and Age-Related Macular Degeneration.

Journal Article Scientific reports · March 2019 Age-related macular degeneration (AMD) - the leading cause of vision loss in the elderly - share many risks factors as atherosclerosis, which exhibits loss of vascular compliance resulting from aging and oxidative stress. Here, we attempt to explore choroi ... Full text Cite

In vivo measurement of trabecular meshwork stiffness in a corticosteroid-induced ocular hypertensive mouse model.

Journal Article Proc Natl Acad Sci U S A · January 29, 2019 Ocular corticosteroids are commonly used clinically. Unfortunately, their administration frequently leads to ocular hypertension, i.e., elevated intraocular pressure (IOP), which, in turn, can progress to a form of glaucoma known as steroid-induced glaucom ... Full text Link to item Cite

Estimation of Gestational Age via Image Analysis of Anterior Lens Capsule Vascularity in Preterm Infants: A Pilot Study.

Journal Article Frontiers in pediatrics · January 2019 Introduction: Anterior lens capsule vascularity (ALCV) is resorbed in the developing fetus from 27 to 35 weeks gestation. In this pilot study, we evaluated the feasibility and validity of combining smartphone ophthalmoscope videos of ALCV and image ... Full text Cite

Computational modeling of retinal hypoxia and photoreceptor degeneration in patients with age-related macular degeneration.

Journal Article PloS one · January 2019 Although drusen have long been acknowledged as a primary hallmark of dry age-related macular degeneration (AMD) their role in the disease remains unclear. We hypothesize that drusen accumulation increases the barrier to metabolite transport ultimately resu ... Full text Cite

An assessment of multimodal imaging of subsurface text in mummy cartonnage using surrogate papyrus phantoms

Journal Article Heritage Science · December 1, 2018 Ancient Egyptian mummies were often covered with an outer casing, panels and masks made from cartonnage: a lightweight material made from linen, plaster, and recycled papyrus held together with adhesive. Egyptologists, papyrologists, and historians aim to ... Full text Cite

Open-source, machine and deep learning-based automated algorithm for gestational age estimation through smartphone lens imaging.

Journal Article Biomedical optics express · December 2018 Gestational age estimation at time of birth is critical for determining the degree of prematurity of the infant and for administering appropriate postnatal treatment. We present a fully automated algorithm for estimating gestational age of premature infant ... Full text Cite

Information-Theoretic Approach and Fundamental Limits of Resolving Two Closely Timed Neuronal Spikes in Mouse Brain Calcium Imaging.

Journal Article IEEE transactions on bio-medical engineering · November 2018 ObjectiveAlthough optical imaging of neurons using fluorescent genetically encoded calcium sensors has enabled large-scale in vivo experiments, the sensors' slow dynamics often blur closely timed action potentials into indistinguishable transients ... Full text Cite

Hand-held ao ophthalmoscopy enables cellular-level imaging

Journal Article Biophotonics International · November 1, 2018 Cite

Handheld Adaptive Optics Scanning Laser Ophthalmoscope.

Journal Article Optica · September 20, 2018 Featured Publication Adaptive optics scanning laser ophthalmoscopy (AOSLO) has enabled in vivo visualization and enhanced understanding of retinal structure and function. Current generation AOSLOs have a large footprint and are mainly limited to imaging cooperative adult subje ... Full text Link to item Cite

Statistical Models of Signal and Noise and Fundamental Limits of Segmentation Accuracy in Retinal Optical Coherence Tomography.

Journal Article IEEE transactions on medical imaging · September 2018 Optical coherence tomography (OCT) has revolutionized diagnosis and prognosis of ophthalmic diseases by visualization and measurement of retinal layers. To speed up the quantitative analysis of disease biomarkers, an increasing number of automatic segmenta ... Full text Cite

Deep learning based detection of cone photoreceptors with multimodal adaptive optics scanning light ophthalmoscope images of achromatopsia.

Journal Article Biomedical optics express · August 2018 Fast and reliable quantification of cone photoreceptors is a bottleneck in the clinical utilization of adaptive optics scanning light ophthalmoscope (AOSLO) systems for the study, diagnosis, and prognosis of retinal diseases. To-date, manual grading has be ... Full text Cite

Real- time Corneal Segmentation and 3D Needle Tracking in Intrasurgical OCT

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Semi-Automated Segmentation of Hyperreflective Foci on Optical Coherence Tomography

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Phase 2 Trial of Ciliary Neurotrophic Factor for Macular Telangiectasia Type 2

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Assessing ganglion cell layer topography in human albinism using optical coherence tomography

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Pentablock Copolymer Dexamethasone Nanoformulations Induced Ocular Hypertension in Mice

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Real-time corneal segmentation and 3D needle tracking in intrasurgical OCT.

Journal Article Biomed Opt Express · June 1, 2018 Ophthalmic procedures demand precise surgical instrument control in depth, yet standard operating microscopes supply limited depth perception. Current commercial microscope-integrated optical coherence tomography partially meets this need with manually-pos ... Full text Link to item Cite

Deep longitudinal transfer learning-based automatic segmentation of photoreceptor ellipsoid zone defects on optical coherence tomography images of macular telangiectasia type 2.

Journal Article Biomed Opt Express · June 1, 2018 Photoreceptor ellipsoid zone (EZ) defects visible on optical coherence tomography (OCT) are important imaging biomarkers for the onset and progression of macular diseases. As such, accurate quantification of EZ defects is paramount to monitor disease progr ... Full text Link to item Cite

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Journal Article American journal of ophthalmology · May 2018 Full text Cite

Linking OCT, Angiographic, and Photographic Lesion Components in Neovascular Age-Related Macular Degeneration.

Journal Article Ophthalmol Retina · May 2018 PURPOSE: To develop methods to make precise comparisons of specific retinal features between and within spectral-domain (SD) OCT images, color fundus photography (CFP) images, and fluorescein angiography (FA) images in eyes treated with anti-vascular endot ... Full text Link to item Cite

Novel Image-Based Analysis for Reduction of Clinician-Dependent Variability in Measurement of the Corneal Ulcer Size.

Journal Article Cornea · March 2018 PurposeTo assess variability in corneal ulcer measurements between ophthalmologists and reduce clinician-dependent variability using semiautomated segmentation of the ulcer from photographs.MethodsThree ophthalmologists measured 50 patien ... Full text Cite

Comparison of chorioretinal layers in rhesus macaques using spectral-domain optical coherence tomography and high-resolution histological sections.

Journal Article Experimental eye research · March 2018 Nonhuman primates are important preclinical models of retinal diseases because they uniquely possess a macula similar to humans. Ocular imaging technologies such as spectral-domain optical coherence tomography (SD-OCT) allow noninvasive, in vivo measuremen ... Full text Cite

Choroidal Changes After Suprachoroidal Injection of Triamcinolone Acetonide in Eyes With Macular Edema Secondary to Retinal Vein Occlusion.

Journal Article American journal of ophthalmology · February 2018 PurposeTo evaluate choroidal and suprachoroidal changes following suprachoroidal injection of triamcinolone acetonide injectable suspension (CLS-TA), in eyes with macular edema due to retinal vein occlusion (RVO).DesignProspective cohort ... Full text Cite

Evaluation of inner retinal layers as biomarkers in mild cognitive impairment to moderate Alzheimer's disease.

Journal Article PLoS One · 2018 Inner retina in Alzheimer's Disease (AD) may experience neuroinflammation resulting in atrophy. The objective of our study was to determine whether retinal GCIPL (ganglion cell-inner plexiform layer) or nerve fiber layer (NFL) thickness may serve as noninv ... Full text Link to item Cite

Integrating optical imaging of mummy mask cartonnage

Conference IS and T Archiving Conference, ARCHIVING 2018 · January 1, 2018 This rapid development and testing project captured data from multiple digital imaging techniques to try to see texts in papyrus mâché mummy mask cartonnage layers. Prior studies by other scholars destroyed the masks to access the papyri, denying future re ... Cite

Effects of aging and environmental tobacco smoke exposure on ocular and plasma circulatory microRNAs in the Rhesus macaque.

Journal Article Molecular vision · January 2018 PurposeTo identify changes induced by environmental tobacco smoke (ETS) in circulatory microRNA (miRNA) in plasma and ocular fluids of the Rhesus macaque and compare these changes to normal age-related changes. Tobacco smoke has been identified as ... Cite

Optical Coherence Tomography Predictors of Risk for Progression to Non-Neovascular Atrophic Age-Related Macular Degeneration.

Conference Ophthalmology · December 2017 PURPOSE: Appearance of geographic atrophy (GA) on color photography (CP) is preceded by specific features on spectral-domain optical coherence tomography (SD OCT). We aimed to build SD OCT-based risk assessment models for 5-year new onset of GA and central ... Full text Link to item Cite

Macular Fluid Reduces Reproducibility of Choroidal Thickness Measurements on Enhanced Depth Optical Coherence Tomography.

Journal Article American journal of ophthalmology · December 2017 PurposeTo determine if different types of retinal fluid in the central macula affect the reproducibility of choroidal thickness (CT) measurements on enhanced depth imaging optical coherence tomography (EDI-OCT).DesignRetrospective reliabi ... Full text Cite

In Vivo Multimodal Imaging of Drusenoid Lesions in Rhesus Macaques.

Journal Article Scientific reports · November 2017 Nonhuman primates are the only mammals to possess a true macula similar to humans, and spontaneously develop drusenoid lesions which are hallmarks of age-related macular degeneration (AMD). Prior studies demonstrated similarities between human and nonhuman ... Full text Cite

Characterization of Long Working Distance Optical Coherence Tomography for Imaging of Pediatric Retinal Pathology.

Journal Article Transl Vis Sci Technol · October 2017 PURPOSE: We determined the feasibility of fovea and optic nerve head imaging with a long working distance (LWD) swept source optical coherence tomography (OCT) prototype in adults, teenagers, and young children. METHODS: A prototype swept source OCT system ... Full text Link to item Cite

Retinal imaging in human autopsy eyes using a custom optical coherence tomography periscope.

Journal Article Biomed Opt Express · September 1, 2017 Age-related macular degeneration (AMD) is a major cause of vision loss in the elderly. To better study the pathobiology of AMD, postmortem eyes offer an excellent opportunity to correlate optical coherence tomography (OCT) imaging characteristics with hist ... Full text Link to item Cite

Open source software for automatic detection of cone photoreceptors in adaptive optics ophthalmoscopy using convolutional neural networks.

Journal Article Scientific reports · July 2017 Imaging with an adaptive optics scanning light ophthalmoscope (AOSLO) enables direct visualization of the cone photoreceptor mosaic in the living human retina. Quantitative analysis of AOSLO images typically requires manual grading, which is time consuming ... Full text Cite

Anatomy and spatial organization of Müller glia in mouse retina.

Journal Article J Comp Neurol · June 1, 2017 Müller glia, the most abundant glia of vertebrate retina, have an elaborate morphology characterized by a vertical stalk that spans the retina and branches in each retinal layer. Müller glia play diverse, critical roles in retinal homeostasis, which are pr ... Full text Link to item Cite

Effect of Sildenafil Citrate on Choroidal Thickness in Age-Related Macular Degeneration

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2017 Link to item Cite

Multimodal Imaging of Drusenoid Lesions in Rhesus Macaques

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2017 Link to item Cite

Optical photon reassignment super-resolution scanning laser ophthalmoscopy

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2017 Link to item Cite

Automatic segmentation of nine retinal layer boundaries in OCT images of non-exudative AMD patients using deep learning and graph search.

Journal Article Biomedical optics express · May 2017 We present a novel framework combining convolutional neural networks (CNN) and graph search methods (termed as CNN-GS) for the automatic segmentation of nine layer boundaries on retinal optical coherence tomography (OCT) images. CNN-GS first utilizes a CNN ... Full text Cite

Correlation Between Macular Integrity Assessment and Optical Coherence Tomography Imaging of Ellipsoid Zone in Macular Telangiectasia Type 2.

Journal Article Invest Ophthalmol Vis Sci · May 1, 2017 PURPOSE: To correlate ellipsoid zone (EZ) defects on spectral-domain optical coherence tomography (SD-OCT) with retinal sensitivity loss on macular integrity assessment (MAIA) microperimetry in macular telangiectasia type 2 (MacTel). METHODS: Macular SD-OC ... Full text Link to item Cite

A Quantitative Approach to Predict Differential Effects of Anti-VEGF Treatment on Diffuse and Focal Leakage in Patients with Diabetic Macular Edema: A Pilot Study.

Journal Article Transl Vis Sci Technol · March 2017 PURPOSE: We use semiautomated segmentation of fluorescein angiography (FA) to determine whether anti-vascular endothelial growth factor (VEGF) treatment for diabetic macular edema (DME) differentially affects microaneurysm (MA)-associated leakage, termed f ... Full text Open Access Link to item Cite

Platform-Independent Cirrus and Spectralis Thickness Measurements in Eyes with Diabetic Macular Edema Using Fully Automated Software.

Journal Article Transl Vis Sci Technol · February 2017 PURPOSE: We determine whether the automated segmentation software, Duke Optical Coherence Tomography Retinal Analysis Program (DOCTRAP), can measure, in a platform-independent manner, retinal thickness on Cirrus and Spectralis spectral domain optical coher ... Full text Link to item Cite

Segmentation Based Sparse Reconstruction of Optical Coherence Tomography Images.

Journal Article IEEE transactions on medical imaging · February 2017 We demonstrate the usefulness of utilizing a segmentation step for improving the performance of sparsity based image reconstruction algorithms. In specific, we will focus on retinal optical coherence tomography (OCT) reconstruction and propose a novel segm ... Full text Cite

Enhanced visualization of peripheral retinal vasculature with wavefront sensorless adaptive optics optical coherence tomography angiography in diabetic patients.

Journal Article Opt Lett · January 1, 2017 Optical coherence tomography angiography (OCTA) is a promising technique for non-invasive visualization of vessel networks in the human eye. We debut a system capable of acquiring wide field-of-view (>70°) OCT angiograms without mosaicking. Additionally, w ... Full text Link to item Cite

Wide-field retinal optical coherence tomography with wavefront sensorless adaptive optics for enhanced imaging of targeted regions.

Journal Article Biomed Opt Express · January 1, 2017 The peripheral retina of the human eye offers a unique opportunity for assessment and monitoring of ocular diseases. We have developed a novel wide-field (>70°) optical coherence tomography system (WF-OCT) equipped with wavefront sensorless adaptive optics ... Full text Link to item Cite

Using an Image Fusion Methodology to Improve Efficiency and Traceability of Posterior Pole Vessel Analysis by ROPtool.

Journal Article Open Ophthalmol J · 2017 BACKGROUND: The diagnosis of plus disease in retinopathy of prematurity (ROP) largely determines the need for treatment; however, this diagnosis is subjective. To make the diagnosis of plus disease more objective, semi-automated computer programs (e.g. ROP ... Full text Link to item Cite

New applications of super-resolution in medical imaging

Chapter · January 1, 2017 The image processing algorithms collectively known as super-resolution have proven effective in producing high-quality imagery from a collection of low-resolution photographic images. In this chapter, we examine some of the advantages and challenges of app ... Full text Cite

Optical Coherence Tomography Reflective Drusen Substructures Predict Progression to Geographic Atrophy in Age-related Macular Degeneration.

Journal Article Ophthalmology · December 2016 PURPOSE: Structural and compositional heterogeneity within drusen comprising lipids, carbohydrates, and proteins have been previously described. We sought to detect and define phenotypic patterns of drusen heterogeneity in the form of optical coherence tom ... Full text Link to item Cite

Optical Coherence Tomography Reflective Drusen Substructures Predict Progression to Geographic Atrophy in Age-related Macular Degeneration.

Journal Article Ophthalmology · December 2016 PURPOSE: Structural and compositional heterogeneity within drusen comprising lipids, carbohydrates, and proteins have been previously described. We sought to detect and define phenotypic patterns of drusen heterogeneity in the form of optical coherence tom ... Full text Link to item Cite

Segmentation guided registration of wide field-of-view retinal optical coherence tomography volumes.

Journal Article Biomed Opt Express · December 1, 2016 Patient motion artifacts are often visible in densely sampled or large wide field-of-view (FOV) retinal optical coherence tomography (OCT) volumes. A popular strategy for reducing motion artifacts is to capture two orthogonally oriented volumetric scans. H ... Full text Link to item Cite

Understanding RPE Lipofuscin.

Journal Article Invest Ophthalmol Vis Sci · December 1, 2016 Full text Link to item Cite

Needle Depth and Big-Bubble Success in Deep Anterior Lamellar Keratoplasty: An Ex Vivo Microscope-Integrated OCT Study.

Journal Article Cornea · November 2016 PURPOSE: To examine big-bubble (BB) formation success rates in deep anterior lamellar keratoplasty (DALK) at various corneal depths using real-time guidance from swept-source, microscope-integrated optical coherence tomography (SS-MIOCT). METHODS: The DALK ... Full text Link to item Cite

Validation of Macular Choroidal Thickness Measurements from Automated SD-OCT Image Segmentation.

Journal Article Optometry and vision science : official publication of the American Academy of Optometry · November 2016 PurposeSpectral domain optical coherence tomography (SD-OCT) imaging permits in vivo visualization of the choroid with micron-level resolution over wide areas and is of interest for studies of ocular growth and myopia control. We evaluated the spe ... Full text Cite

Effect of Uveal Melanocytes on Choroidal Morphology in Rhesus Macaques and Humans on Enhanced-Depth Imaging Optical Coherence Tomography.

Journal Article Investigative ophthalmology & visual science · October 2016 PurposeTo compare cross-sectional choroidal morphology in rhesus macaque and human eyes using enhanced-depth imaging optical coherence tomography (EDI-OCT) and histologic analysis.MethodsEnhanced-depth imaging-OCT images from 25 rhesus ma ... Full text Cite

Visualization of conventional outflow tissue responses to netarsudil in living mouse eyes.

Journal Article Eur J Pharmacol · September 15, 2016 Visual impairment due to glaucoma currently impacts 70 million people worldwide. While disease progression can be slowed or stopped with effective lowering of intraocular pressure, current medical treatments are often inadequate. Fortunately, three new cla ... Full text Link to item Cite

Repeatability of Choroidal Thickness Measurements on Enhanced Depth Imaging Optical Coherence Tomography Using Different Posterior Boundaries.

Journal Article American journal of ophthalmology · September 2016 PurposeTo assess the reliability of manual choroidal thickness measurements by comparing different posterior boundary definitions of the choroidal-scleral junction on enhanced depth imaging optical coherence tomography (EDI-OCT).DesignRel ... Full text Cite

Retinal Biomarkers of Alzheimer's Disease

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · September 1, 2016 Link to item Cite

IOP-induced Changes in Schlemm's Canal Dimensions and the Relation to Shear Stress

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · September 1, 2016 Link to item Cite

Topography of the Vitreoretinal Interface in Vitreomacular Traction Syndrome

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · September 1, 2016 Link to item Cite

Segmentation and analysis software for mapping aqueous humor outflow pattern in living mice

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · September 1, 2016 Link to item Cite

Real-time Visualization of AR-13324 Effects on Schlemm's Canal and Scleral Vessels in Living Mice

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · September 1, 2016 Link to item Cite

Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography.

Journal Article Sci Rep · August 19, 2016 Minimally-invasive microsurgery has resulted in improved outcomes for patients. However, operating through a microscope limits depth perception and fixes the visual perspective, which result in a steep learning curve to achieve microsurgical proficiency. W ... Full text Open Access Link to item Cite

Macular sub-layer thinning and association with pulmonary function tests in Amyotrophic Lateral Sclerosis.

Journal Article Scientific reports · July 2016 Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disorder that may have anterior visual pathway involvement. In this study, we compare the macular structure of patients with ALS to healthy controls, and examine correlations between macula ... Full text Cite

Posterior Eye Shape Measurement With Retinal OCT Compared to MRI.

Journal Article Invest Ophthalmol Vis Sci · July 1, 2016 PURPOSE: Posterior eye shape assessment by magnetic resonance imaging (MRI) is used to study myopia. We tested the hypothesis that optical coherence tomography (OCT), as an alternative, could measure posterior eye shape similarly to MRI. METHODS: Macular s ... Full text Link to item Cite

Impact of Microscope-Integrated OCT on Ophthalmology Resident Performance of Anterior Segment Surgical Maneuvers in Model Eyes.

Journal Article Invest Ophthalmol Vis Sci · July 1, 2016 PURPOSE: The integration of swept-source optical coherence tomography (SS-OCT) into the operating microscope enables real-time, tissue-level three-dimensional (3D) imaging to aid in ophthalmic microsurgery. In this prospective randomized controlled study, ... Full text Link to item Cite

Longitudinal Associations Between Microstructural Changes and Microperimetry in the Early Stages of Age-Related Macular Degeneration.

Journal Article Invest Ophthalmol Vis Sci · July 1, 2016 PURPOSE: To determine whether longitudinal changes in mesopic visual function on microperimetry occurred independent of its associations with microstructural parameters on spectral-domain optical coherence tomography (SD-OCT) in the early stages of AMD. ME ... Full text Link to item Cite

Length-adaptive graph search for automatic segmentation of pathological features in optical coherence tomography images.

Journal Article J Biomed Opt · July 1, 2016 We introduce a metric in graph search and demonstrate its application for segmenting retinal optical coherence tomography (OCT) images of macular pathology. Our proposed “adjusted mean arc length” (AMAL) metric is an adaptation of the lowest mean arc lengt ... Full text Link to item Cite

Glucose variability and inner retinal sensory neuropathy in persons with type 1 diabetes mellitus.

Journal Article Eye (London, England) · June 2016 PurposeTo quantify early neuroretinal alterations in patients with type 1 diabetes mellitus (T1DM) and to assess whether glycemic variability contributes to alterations in neuroretinal structure or function.MethodsThirty patients with T1DM and 51 controls ... Full text Cite

Relating Retinal Morphology and Function in Aging and Early to Intermediate Age-related Macular Degeneration Subjects.

Journal Article Am J Ophthalmol · May 2016 PURPOSE: To evaluate relationships between age-related macular degeneration (AMD) morphology on spectral-domain optical coherence tomography (SDOCT) and visual function. DESIGN: Cross-sectional, observational. METHODS: From the Alabama Study on Early AMD b ... Full text Link to item Cite

Automatic detection of cone photoreceptors in split detector adaptive optics scanning light ophthalmoscope images.

Journal Article Biomedical optics express · May 2016 Quantitative analysis of the cone photoreceptor mosaic in the living retina is potentially useful for early diagnosis and prognosis of many ocular diseases. Non-confocal split detector based adaptive optics scanning light ophthalmoscope (AOSLO) imaging rev ... Full text Cite

Optical coherence tomography noise modeling and fundamental bounds on human retinal layer segmentation accuracy (Conference Presentation)

Conference Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX · April 26, 2016 Full text Cite

Label-free vascular imaging in a spontaneous hamster cheek pouch carcinogen model for pre-cancer detection (Conference Presentation)

Conference Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis · April 26, 2016 Full text Cite

Novel real-time volumetric tool segmentation algorithm for intraoperative microscope integrated OCT (Conference Presentation)

Conference Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX · April 26, 2016 Full text Cite

Analyzing spatial correlations in tissue using angle-resolved low coherence interferometry measurements guided by co-located optical coherence tomography.

Journal Article Biomed Opt Express · April 1, 2016 Angle-resolved low coherence interferometry (a/LCI) is an optical technique used to measure nuclear morphology in situ. However, a/LCI is not an imaging modality and can produce ambiguous results when the measurements are not properly oriented to the tissu ... Full text Link to item Cite

Semiautomatic Segmentation of Rim Area Focal Hyperautofluorescence Predicts Progression of Geographic Atrophy Due to Dry Age-Related Macular Degeneration.

Journal Article Invest Ophthalmol Vis Sci · April 1, 2016 PURPOSE: To develop image analysis software usable by nonexpert graders to segment geographic atrophy (GA) from dry AMD and to quantify rim area focal hyperautofluorescence (RAFH) surrounding GA on fundus autofluorescence (FAF) images. To compare the GA pr ... Full text Link to item Cite

Drusen Volume and Retinal Pigment Epithelium Abnormal Thinning Volume Predict 2-Year Progression of Age-Related Macular Degeneration.

Journal Article Ophthalmology · January 2016 PURPOSE: To analyze the value of novel measures of retinal pigment epithelium-drusen complex (RPEDC) volume to predict 2-year disease progression of intermediate age-related macular degeneration (AMD). DESIGN: Prospective, observational study. PARTICIPANTS ... Full text Link to item Cite

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Other Ophthalmology · January 2016 Full text Link to item Cite

The Effects of Diabetic Retinopathy and Pan-Retinal Photocoagulation on Photoreceptor Cell Function as Assessed by Dark Adaptometry.

Journal Article Investigative ophthalmology & visual science · January 2016 PurposeThe pathophysiology of vision loss in persons with diabetic retinopathy (DR) is complex and incompletely defined. We hypothesized that retinal pigment epithelium (RPE) and rod and cone photoreceptor dysfunction, as measured by dark adaptome ... Full text Cite

Retinal nerve fiber layer thickness in amnestic mild cognitive impairment: Case-control study and meta-analysis.

Journal Article Alzheimer's & dementia (Amsterdam, Netherlands) · January 2016 IntroductionRetinal structural changes in subjects with mild cognitive impairment (MCI) remain a subject of controversy.MethodsWe investigated the correlation between optical coherence tomography (OCT) of the retinal sublayers, including ... Full text Cite

Retinal Artery-Vein Classification via Topology Estimation.

Journal Article IEEE Trans Med Imaging · December 2015 We propose a novel, graph-theoretic framework for distinguishing arteries from veins in a fundus image. We make use of the underlying vessel topology to better classify small and midsized vessels. We extend our previously proposed tree topology estimation ... Full text Link to item Cite

Physical Factors Affecting Outflow Facility Measurements in Mice.

Journal Article Invest Ophthalmol Vis Sci · December 2015 PURPOSE: Mice are commonly used to study conventional outflow physiology. This study examined how physical factors (hydration, temperature, and anterior chamber [AC] deepening) influence ocular perfusion measurements in mice. METHODS: Outflow facility (C) ... Full text Link to item Cite

Tree topology estimation

Journal Article IEEE Transactions on Pattern Analysis and Machine Intelligence · August 1, 2015 Featured Publication Tree-like structures are fundamental in nature, and it is often useful to reconstruct the topology of a tree-what connects to what-from a two-dimensional image of it. However, the projected branches often cross in the image: the tree projects to a planar g ... Full text Cite

INTRAOPERATIVE SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY IMAGING AFTER INTERNAL LIMITING MEMBRANE PEELING IN IDIOPATHIC EPIRETINAL MEMBRANE WITH CONNECTING STRANDS.

Journal Article Retina · August 2015 PURPOSE: To report the intraoperative optical coherence tomography findings in idiopathic epiretinal membrane (ERM) with connecting strands and to describe the postoperative outcomes. METHODS: A retrospective, case series study within a prospective observa ... Full text Link to item Cite

Intrasurgical Human Retinal Imaging With Manual Instrument Tracking Using a Microscope-Integrated Spectral-Domain Optical Coherence Tomography Device.

Journal Article Transl Vis Sci Technol · July 2015 PURPOSE: To characterize the first in-human intraoperative imaging using a custom prototype spectral-domain microscope-integrated optical coherence tomography (MIOCT) device during vitreoretinal surgery with instruments in the eye. METHODS: Under instituti ... Full text Link to item Cite

Retinal atrophy in eyes with resolved papilledema detected by optical coherence tomography.

Journal Article J Neuroophthalmol · June 2015 BACKGROUND: To apply automated spectral domain optical coherence tomography (SD-OCT) segmentation to eyes with resolving papilledema. METHODS: Ninety-four patients with idiopathic intracranial hypertension seen at the Duke Eye Center neuro-ophthalmology cl ... Full text Link to item Cite

Retinal imaging biomarkers for early diagnosis of Alzheimer's disease

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2015 Link to item Cite

Relationship of Central Choroidal Thickness with Age-Related Macular Degeneration Status

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2015 Link to item Cite

Retinal Macrophages in Stages of Age-related Macular Degeneration

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2015 Link to item Cite

Retinal Structural Changes in Amyotrophic Lateral Sclerosis (ALS)

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2015 Link to item Cite

Comparing retinal sensitivity and SDOCT volumes in the AMD Phenotype and Genotype study

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2015 Link to item Cite

Relationship of central choroidal thickness with age-related macular degeneration status.

Journal Article Am J Ophthalmol · April 2015 PURPOSE: To compare choroidal thickness in patients with intermediate or advanced age-related macular degeneration (AMD) and control subjects using enhanced-depth imaging optical coherence tomography (EDI-OCT). DESIGN: Retrospective cross-sectional study o ... Full text Link to item Cite

Assessment of retinal nerve fiber layer thickness in healthy, full-term neonates.

Journal Article Am J Ophthalmol · April 2015 PURPOSE: To measure average retinal nerve fiber layer (RNFL) thicknesses in healthy, full-term neonates. DESIGN: Descriptive research to develop normative data. METHODS: Healthy infants born between 37 and 42 weeks postmenstrual age were imaged with hand-h ... Full text Link to item Cite

Kernel regression based segmentation of optical coherence tomography images with diabetic macular edema.

Journal Article Biomed Opt Express · April 1, 2015 We present a fully automatic algorithm to identify fluid-filled regions and seven retinal layers on spectral domain optical coherence tomography images of eyes with diabetic macular edema (DME). To achieve this, we developed a kernel regression (KR)-based ... Full text Link to item Cite

Ultra-compact switchable SLO/OCT handheld probe design

Conference SPIE Proceedings · March 4, 2015 Full text Cite

Fully automatic segmentation of fluorescein leakage in subjects with diabetic macular edema.

Journal Article Invest Ophthalmol Vis Sci · January 29, 2015 PURPOSE: To create and validate software to automatically segment leakage area in real-world clinical fluorescein angiography (FA) images of subjects with diabetic macular edema (DME). METHODS: Fluorescein angiography images obtained from 24 eyes of 24 sub ... Full text Link to item Cite

3-D Adaptive Sparsity Based Image Compression with Applications to Optical Coherence Tomography

Journal Article IEEE Transactions on Medical Imaging, (IN PRESS) · 2015 Cite

True color scanning laser ophthalmoscopy and optical coherence tomography handheld probe.

Journal Article Biomedical optics express · September 2014 Scanning laser ophthalmoscopes (SLOs) are able to achieve superior contrast and axial sectioning capability compared to fundus photography. However, SLOs typically use monochromatic illumination and are thus unable to extract color information of the retin ... Full text Cite

Coherence revival multiplexed, buffered swept source optical coherence tomography: 400 kHz imaging with a 100 kHz source.

Journal Article Optics letters · July 2014 The effective speed of a swept source optical coherence tomography (SSOCT) imaging system was quadrupled using efficient sweep buffering along with coherence revival and spatial multiplexing. A polarizing beam splitter and fold mirror assembly were used to ... Full text Cite

Dynamic alterations in conventional outflow function in Bmp2-induced ocular hypertensive mice

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2014 Link to item Cite

Compressed Wavefront Aberrometry of the Human Eye

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2014 Link to item Cite

Patient-specific modeling of retinal oxygen as a predictor of AMD progression

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2014 Link to item Cite

Handheld Simultaneous True Color SLO-OCT System

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2014 Link to item Cite

Pilocarpine-induced dilation of Schlemm's canal and prevention of lumen collapse at elevated intraocular pressures in living mice visualized by OCT.

Journal Article Invest Ophthalmol Vis Sci · March 4, 2014 PURPOSE: The goal was to assess effects of IOP and pilocarpine-induced ciliary muscle contraction on conventional outflow pathway tissues in living anesthetized mice. METHODS: Intraocular pressure was controlled by intracameral cannulation of mouse eyes wh ... Full text Link to item Cite

Compressed wavefront sensing.

Journal Article Opt Lett · March 1, 2014 Featured Publication We report on an algorithm for fast wavefront sensing that incorporates sparse representation for the first time in practice. The partial derivatives of optical wavefronts were sampled sparsely with a Shack-Hartman wavefront sensor (SHWFS) by randomly subsa ... Full text Link to item Cite

Characterization of the choroid-scleral junction and suprachoroidal layer in healthy individuals on enhanced-depth imaging optical coherence tomography.

Journal Article JAMA Ophthalmol · February 2014 IMPORTANCE: Accurate measurements of choroidal thickness (CT) using enhanced-depth imaging optical coherence tomography (EDI-OCT) require a well-defined choroid-scleral junction (CSJ), which may appear in some eyes as a hyporeflective band corresponding to ... Full text Link to item Cite

Automatic segmentation of up to ten layer boundaries in SD-OCT images of the mouse retina with and without missing layers due to pathology.

Journal Article Biomed Opt Express · February 1, 2014 Accurate quantification of retinal layer thicknesses in mice as seen on optical coherence tomography (OCT) is crucial for the study of numerous ocular and neurological diseases. However, manual segmentation is time-consuming and subjective. Previous attemp ... Full text Link to item Cite

Lateral and axial measurement differences between spectral-domain optical coherence tomography systems.

Journal Article J Biomed Opt · January 2014 We assessed the reproducibility of lateral and axial measurements performed with spectral-domain optical coherence tomography (SDOCT) instruments from a single manufacturer and across several manufacturers. One human retina phantom was imaged on two instru ... Full text Link to item Cite

Disease progression in iridocorneal angle tissues of BMP2-induced ocular hypertensive mice with optical coherence tomography.

Journal Article Mol Vis · 2014 PURPOSE: The goal of the present study was to test for the first time whether glaucomatous-like disease progression in a mouse can be assessed morphologically and functionally with spectral domain optical coherence tomography (SD-OCT). METHODS: We monitore ... Link to item Cite

Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging.

Journal Article Invest Ophthalmol Vis Sci · December 13, 2013 Age-related macular degeneration is the leading cause of irreversible visual dysfunction in individuals over 65 in Western Society. Patients with AMD are classified as having early stage disease (early AMD), in which visual function is affected, or late AM ... Full text Link to item Cite

Fully automatic software for retinal thickness in eyes with diabetic macular edema from images acquired by cirrus and spectralis systems.

Journal Article Invest Ophthalmol Vis Sci · November 15, 2013 PURPOSE: To determine whether a novel automatic segmentation program, the Duke Optical Coherence Tomography Retinal Analysis Program (DOCTRAP), can be applied to spectral-domain optical coherence tomography (SD-OCT) images obtained from different commercia ... Full text Link to item Cite

Fast acquisition and reconstruction of optical coherence tomography images via sparse representation.

Journal Article IEEE Trans Med Imaging · November 2013 Featured Publication In this paper, we present a novel technique, based on compressive sensing principles, for reconstruction and enhancement of multi-dimensional image data. Our method is a major improvement and generalization of the multi-scale sparsity based tomographic den ... Full text Link to item Cite

Optimization of confocal scanning laser ophthalmoscope design.

Journal Article Journal of biomedical optics · July 2013 Confocal scanning laser ophthalmoscopy (cSLO) enables high-resolution and high-contrast imaging of the retina by employing spatial filtering for scattered light rejection. However, to obtain optimized image quality, one must design the cSLO around scanner ... Full text Cite

Choroid development and feasibility of choroidal imaging in the preterm and term infants utilizing SD-OCT.

Journal Article Invest Ophthalmol Vis Sci · June 14, 2013 PURPOSE: To determine whether choroidal imaging is feasible in preterm and term infants using an 840-nm portable spectral domain optical coherence tomography (SD-OCT) system without the use of enhanced-depth imaging techniques and to assess choroidal devel ... Full text Link to item Cite

Retinal Photoreceptor Development and Maturation in Preterm and Term Infants

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2013 Link to item Cite

Handheld Combined SLO/OCT System

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2013 Link to item Cite

Structural changes in the retina and cornea during diabetic neuropathy

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2013 Link to item Cite

Automatic cone photoreceptor segmentation using graph theory and dynamic programming.

Journal Article Biomed Opt Express · June 1, 2013 Geometrical analysis of the photoreceptor mosaic can reveal subclinical ocular pathologies. In this paper, we describe a fully automatic algorithm to identify and segment photoreceptors in adaptive optics ophthalmoscope images of the photoreceptor mosaic. ... Full text Link to item Cite

Automated non-rigid registration and mosaicing for robust imaging of distinct retinal capillary beds using speckle variance optical coherence tomography.

Journal Article Biomedical optics express · June 2013 Variance processing methods in Fourier domain optical coherence tomography (FD-OCT) have enabled depth-resolved visualization of the capillary beds in the retina due to the development of imaging systems capable of acquiring A-scan data in the 100 kHz regi ... Full text Cite

Handheld simultaneous scanning laser ophthalmoscopy and optical coherence tomography system.

Journal Article Biomedical optics express · January 2013 Scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) are widely used retinal imaging modalities that can assist in the diagnosis of retinal pathologies. The combination of SLO and OCT provides a more comprehensive imaging system and a ... Full text Cite

Macular findings in healthy full-term Hispanic newborns observed by hand-held spectral-domain optical coherence tomography.

Journal Article Ophthalmic Surg Lasers Imaging Retina · 2013 BACKGROUND AND OBJECTIVE: To enhance understanding of ethnically diverse normal newborn retinal morphology, the authors report spectral-domain optical coherence tomography (SD-OCT) macular findings in healthy Hispanic newborns. PATIENTS AND METHODS: In thi ... Full text Link to item Cite

Distributed scan SDOCT improves post refractive surgery corneal biometry

Journal Article Biomedical Optics, BIOMED 2012 · December 1, 2012 We report on a preliminary study comparing corneal refractive power acquired using istributed scanning OCT (DSOCT) to corneal topography and Scheimpflug photography in normal subjects both before and after refractive surgery. © 2012. ... Cite

Distributed scan SDOCT improves post refractive surgery corneal biometry

Conference Digital Holography and Three-Dimensional Imaging, DH 2012 · December 1, 2012 We report on a preliminary study comparing corneal refractive power acquired using distributed scanning OCT (DSOCT) to corneal topography and Scheimpflug photography in normal subjects both before and after refractive surgery. ... Cite

Distributed scanning volumetric SDOCT for motion corrected corneal biometry.

Journal Article Biomed Opt Express · September 1, 2012 We present a method, termed distributed scanning OCT (DSOCT), which reduces the effects of patient motion on corneal biometry utilizing current-generation clinically available spectral domain optical coherence tomography (SDOCT) systems. We first performed ... Full text Link to item Cite

Spatial correlation between hyperpigmentary changes on color fundus photography and hyperreflective foci on SDOCT in intermediate AMD.

Journal Article Invest Ophthalmol Vis Sci · July 9, 2012 PURPOSE: Macular hyperpigmentation is associated with progression from intermediate to advanced age-related macular degeneration (AMD). The purpose of this study was to accurately correlate hyperpigmentary changes with spectral domain optical coherence tom ... Full text Link to item Cite

Foveal avascular zone and foveal pit formation after preterm birth.

Journal Article The British journal of ophthalmology · July 2012 BackgroundVascularisation of the macula takes place between 24 and 27 weeks post-conception. Preterm birth may affect the formation of the foveal avascular zone (FAZ) and foveal depression, and displacement of inner retinal layers away from the in ... Full text Cite

Corneal biometry from volumetric SDOCT and comparison with existing clinical modalities.

Journal Article Biomed Opt Express · June 1, 2012 We present a comparison of corneal biometric values from dense volumetric spectral domain optical coherence tomography (SDOCT) scans to reference values in both phantoms and clinical subjects. We also present a new optically based "keratometric equivalent ... Full text Link to item Cite

Sparsity based denoising of spectral domain optical coherence tomography images.

Journal Article Biomed Opt Express · May 1, 2012 In this paper, we make contact with the field of compressive sensing and present a development and generalization of tools and results for reconstructing irregularly sampled tomographic data. In particular, we focus on denoising Spectral-Domain Optical Coh ... Full text Link to item Cite

Automatic segmentation of closed-contour features in ophthalmic images using graph theory and dynamic programming.

Journal Article Biomed Opt Express · May 1, 2012 This paper presents a generalized framework for segmenting closed-contour anatomical and pathological features using graph theory and dynamic programming (GTDP). More specifically, the GTDP method previously developed for quantifying retinal and corneal la ... Full text Link to item Cite

Image inversion spectral-domain optical coherence tomography optimizes choroidal thickness and detail through improved contrast.

Journal Article Invest Ophthalmol Vis Sci · April 6, 2012 PURPOSE: This study was conducted to determine whether there were significant differences in choroidal thickness, contrast, outer choroidal vessel (OCV), and choroidal-scleral junction (CSJ) visualization in inverted versus upright spectral-domain optical ... Full text Link to item Cite

Exploratory Dijkstra forest based automatic vessel segmentation: applications in video indirect ophthalmoscopy (VIO).

Journal Article Biomed Opt Express · February 1, 2012 We present a methodology for extracting the vascular network in the human retina using Dijkstra's shortest-path algorithm. Our method preserves vessel thickness, requires no manual intervention, and follows vessel branching naturally and efficiently. To te ... Full text Link to item Cite

Validated automatic segmentation of AMD pathology including drusen and geographic atrophy in SD-OCT images.

Journal Article Invest Ophthalmol Vis Sci · January 5, 2012 PURPOSE: To automatically segment retinal spectral domain optical coherence tomography (SD-OCT) images of eyes with age-related macular degeneration (AMD) and various levels of image quality to advance the study of retinal pigment epithelium (RPE)+drusen c ... Full text Link to item Cite

Subfoveal fluid in healthy full-term newborns observed by handheld spectral-domain optical coherence tomography.

Journal Article Am J Ophthalmol · January 2012 PURPOSE: To report retinal findings for healthy newborn infants imaged with handheld spectral-domain optical coherence tomography (SD OCT). DESIGN: Prospective, observational case series. METHODS: Thirty-nine full-term newborn infants underwent dilated ret ... Full text Link to item Cite

Dynamics of human foveal development after premature birth.

Journal Article Ophthalmology · December 2011 PURPOSE: To determine the dynamic morphologic development of the human fovea in vivo using portable spectral domain-optical coherence tomography (SD-OCT). DESIGN: Prospective, observational case series. PARTICIPANTS: Thirty-one prematurely born neonates, 9 ... Full text Link to item Cite

Analysis of pars plana vitrectomy for optic pit-related maculopathy with intraoperative optical coherence tomography: a possible connection with the vitreous cavity.

Journal Article Arch Ophthalmol · November 2011 Optimal management of optic pit-related maculopathy remains to be determined. The fluid source for the maculopathy also remains controversial. In this article, we present a unique surgical technique for internal drainage of the intraretinal fluid and descr ... Full text Link to item Cite

Enhanced video indirect ophthalmoscopy (VIO) via robust mosaicing.

Journal Article Biomed Opt Express · October 1, 2011 Indirect ophthalmoscopy (IO) is the standard of care for evaluation of the neonatal retina. When recorded on video from a head-mounted camera, IO images have low quality and narrow Field of View (FOV). We present an image fusion methodology for converting ... Full text Link to item Cite

Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration.

Journal Article Proc Natl Acad Sci U S A · July 12, 2011 Age-related macular degeneration (AMD) is a leading cause of visual dysfunction worldwide. Amyloid β (Aβ) peptides, Aβ1-40 (Aβ40) and Aβ1-42 (Aβ42), have been implicated previously in the AMD disease process. Consistent with a pathogenic role for Aβ, we sh ... Full text Link to item Cite

Robust automatic segmentation of corneal layer boundaries in SDOCT images using graph theory and dynamic programming.

Journal Article Biomed Opt Express · June 1, 2011 Segmentation of anatomical structures in corneal images is crucial for the diagnosis and study of anterior segment diseases. However, manual segmentation is a time-consuming and subjective process. This paper presents an automatic approach for segmenting c ... Full text Link to item Cite

Integration of a spectral domain optical coherence tomography system into a surgical microscope for intraoperative imaging.

Journal Article Invest Ophthalmol Vis Sci · May 16, 2011 PURPOSE: To demonstrate an operating microscope-mounted spectral domain optical coherence tomography (MMOCT) system for human retinal and model surgery imaging. METHODS: A prototype MMOCT system was developed to interface directly with an ophthalmic surgic ... Full text Link to item Cite

Proteomic profiling of a layered tissue reveals unique glycolytic specializations of photoreceptor cells.

Journal Article Mol Cell Proteomics · March 2011 The retina is a highly ordered tissue whose outermost layers are formed by subcellular compartments of photoreceptors generating light-evoked electrical responses. We studied protein distributions among individual photoreceptor compartments by separating t ... Full text Link to item Cite

Evaluation of contrast agents for enhanced visualization in optical coherence tomography.

Journal Article Invest Ophthalmol Vis Sci · December 2010 PURPOSE: To identify and evaluate the use of contrast agents in optical coherence tomography (OCT) for ophthalmic applications. METHODS: Three agents-prednisolone acetate (PA), triamcinolone acetonide (TA), and lipid-based artificial tears (LBAT)-were test ... Full text Link to item Cite

Segmentation of ophthalmic Optical Coherence Tomography images using graph cuts

Chapter · December 1, 2010 We describe an efficient approach for the automated segmentation of pathological/morphological structures in ophthalmic Spectral Domain Optical Coherence Tomography (SDOCT) images. In this algorithm, image pixels are treated as nodes of a graph with edge w ... Full text Cite

Quantitative comparison of drusen segmented on SD-OCT versus drusen delineated on color fundus photographs.

Journal Article Invest Ophthalmol Vis Sci · October 2010 PURPOSE: Spectral domain-optical coherence tomography (SD-OCT) may be useful for efficient measurement of drusen in patients with age-related macular degeneration (AMD). Areas identified as drusen from semiautomated segmentation of drusen on SD-OCT were co ... Full text Link to item Cite

Efficient fourier-wavelet super-resolution.

Journal Article IEEE Trans Image Process · October 2010 Featured Publication Super-resolution (SR) is the process of combining multiple aliased low-quality images to produce a high-resolution high-quality image. Aside from registration and fusion of low-resolution images, a key process in SR is the restoration and denoising of the ... Full text Link to item Cite

Automatic segmentation of seven retinal layers in SDOCT images congruent with expert manual segmentation.

Journal Article Opt Express · August 30, 2010 Segmentation of anatomical and pathological structures in ophthalmic images is crucial for the diagnosis and study of ocular diseases. However, manual segmentation is often a time-consuming and subjective process. This paper presents an automatic approach ... Full text Open Access Link to item Cite

Interlaced spectrally encoded confocal scanning laser ophthalmoscopy and spectral domain optical coherence tomography.

Journal Article Biomedical optics express · August 2010 Scanning laser ophthalmoscopy (SLO) and spectral domain optical coherence tomography (SDOCT) have become essential clinical diagnostic tools in ophthalmology by allowing for video-rate noninvasive en face and depth-resolved visualization of retinal structu ... Full text Cite

SDOCT Measurement of Corneal Power and Comparision With Standard Techniques

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2010 Link to item Cite

Automated Segmentation of Seven Retinal Layers in SDOCT Congruent With Expert Manual Segmentation

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2010 Link to item Cite

Applications of spectral-domain OCT in AMD

Chapter · December 1, 2009 High-resolution optical imaging of objects hidden in scattering media such as the human eye is a challenging and important problem with many industrial and medical applications. © 2009 Springer Berlin Heidelberg. ... Full text Cite

Insights into advanced retinopathy of prematurity using handheld spectral domain optical coherence tomography imaging.

Journal Article Ophthalmology · December 2009 PURPOSE: To elucidate the subclinical anatomy of retinopathy of prematurity (ROP) using spectral domain optical coherence tomography (SD OCT). DESIGN: Prospective, observational case series. PARTICIPANTS: Three low-birth-weight, severely premature infants. ... Full text Link to item Cite

Generalized pseudo-polar fourier grids and applications in registering ophthalmic optical coherence tomography images

Journal Article Conference Record - Asilomar Conference on Signals, Systems and Computers · December 1, 2009 Fast and accurate estimation of the Fourier transform in polar coordinates has long been a major challenge for many image processing applications including phase-correlation based motion estimation. To address this problem, it has been proposed to calculat ... Full text Cite

Power trace: An efficient method for extracting the power dissipation profile in an IC chip from its temperature map

Journal Article IEEE Transactions on Components and Packaging Technologies · August 14, 2009 In this paper, we present a new technique to calculate the power dissipation profile from the IC temperature map using a process analogous to image processing and restoration. In this technique, finite-element analysis (FEA) is used to find the heat-point ... Full text Cite

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Other American Journal of Ophthalmology · June 1, 2009 Full text Cite

Photoreceptor layer thinning over drusen in eyes with age-related macular degeneration imaged in vivo with spectral-domain optical coherence tomography.

Journal Article Ophthalmology · March 2009 PURPOSE: Detect changes in the neurosensory retina using spectral-domain optical coherence tomography (SD OCT) imaging over drusen in age-related macular degeneration (AMD). Quantitative imaging biomarkers may aid in defining risk of disease progression. D ... Full text Link to item Cite

Imaging the infant retina with a hand-held spectral-domain optical coherence tomography device.

Journal Article Am J Ophthalmol · February 2009 PURPOSE: To evaluate and treat infant retina through the use of a hand-held spectral-domain optical coherence tomography (SD OCT) device in selected cases of Shaken Baby syndrome (SBS). DESIGN: Observational case series. METHODS: A novel SD OCT system was ... Full text Link to item Cite

Abnormal foveal morphology in ocular albinism imaged with spectral-domain optical coherence tomography.

Journal Article Arch Ophthalmol · January 2009 OBJECTIVES: To evaluate the spectrum of foveal architecture in pediatric albinism and to assess the utility of spectral-domain optical coherence tomography (OCT) in ocular imaging of children with nystagmus. METHODS: Spectral-domain OCT imaging was perform ... Full text Link to item Cite

Intraoperative use of handheld spectral domain optical coherence tomography imaging in macular surgery.

Journal Article Retina · 2009 PURPOSE: To describe the intraoperative use of handheld spectral domain optical coherence tomography (SDOCT) imaging in macular surgery. DESIGN: Prospective, observational case series. METHODS: A handheld SDOCT device was used to obtain preincision optical ... Full text Link to item Cite

Optimal registration of aliased images using variable projection with applications to super-resolution

Journal Article Computer Journal · January 1, 2009 Accurate registration of images is the most important and challenging aspect of multiframe image restoration problems such as super-resolution. The accuracy of super-resolution algorithms is quite often limited by the ability to register a set of low-resol ... Full text Cite

Efficient restoration and enhancement of super-resolved X-ray images

Chapter · December 1, 2008 Our previous work demonstrates the ability to reconstruct a single higher resolution image from fusing a collection of multiple extremely low-dosage aliased X-ray images. While this computationally efficient method eliminates aliasing artifacts associated ... Full text Cite

Fast detection and segmentation of drusen in retinal optical coherence tomography images

Chapter · May 26, 2008 Accurate detection-characterization of drusen is an important imaging biomarker of age-related macular degeneration (AMD) progression. We report on the development of an automatic method for detection and segmentation of drusen in retinal images captured v ... Full text Cite

Spectral-domain OCT in practice

Other Retina Today · May 1, 2008 Cite

Deblurring using regularized locally adaptive kernel regression.

Journal Article IEEE transactions on image processing : a publication of the IEEE Signal Processing Society · April 2008 Kernel regression is an effective tool for a variety of image processing tasks such as denoising and interpolation [1]. In this paper, we extend the use of kernel regression for deblurring applications. In some earlier examples in the literature, such nonp ... Full text Cite

Simultaneous demosaicking and resolution enhancement from under-sampled image sequences

Chapter · January 1, 2008 Single-sensor imaging provides a convenient, yet low-cost solution for the problem of capturing color images at multiple wavelengths. To capture color, single-sensor cameras add a color filter array (CFA) [1], [2] on top of the photo-detector array. The CF ... Cite

Efficient Restoration and Enhancement of Super-resolved X-ray Images

Conference 2008 IEEE INTERNATIONAL CONFERENCE ON IMAGE PROCESSING, PROCEEDINGS · January 1, 2008 Link to item Cite

Efficient registration of aliased x-ray images

Other Conference Record - Asilomar Conference on Signals, Systems and Computers · December 1, 2007 Multiframe image reconstruction produces images beyond the native resolution of a digital image sensor by way of accurate sub-pixel registration of aliased images. We present a novel multiframe registration approach for the purpose of enhancing resolution ... Full text Cite

Higher order bilateral filters and their properties

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · August 31, 2007 Bilateral filtering1,2 has proven to be a powerful tool for adaptive denoising purposes. Unlike conventional filters, the bilateral filter defines the closeness of two pixels not only based on geometric distance but also based on radiometric (graylevel) di ... Full text Cite

Extraction of power dissipation profile in an IC chip from temperature map

Journal Article Annual IEEE Semiconductor Thermal Measurement and Management Symposium · August 27, 2007 In this paper, we present a new technique to calculate the power dissipation profile from the IC temperature map using an analogy with image processing and restoration. In this technique, finite element analysis (FEA) is used to find the heat point spread ... Full text Cite

Statistical detection and imaging of objects hidden in turbid media using ballistic photons.

Journal Article Appl Opt · August 10, 2007 We exploit recent advances in active high-resolution imaging through scattering media with ballistic photons. We derive the fundamental limits on the accuracy of the estimated parameters of a mathematical model that describes such an imaging scenario and c ... Full text Link to item Cite

Kernel regression for image processing and reconstruction.

Journal Article IEEE transactions on image processing : a publication of the IEEE Signal Processing Society · February 2007 In this paper, we make contact with the field of nonparametric statistics and present a development and generalization of tools and results for use in image processing and reconstruction. In particular, we adapt and expand kernel regression ideas for use i ... Full text Cite

Multi-scale statistical detection and ballistic imaging through turbid media

Conference 2007 IEEE INTERNATIONAL CONFERENCE ON IMAGE PROCESSING, VOLS 1-7 · January 1, 2007 Link to item Cite

Robust kernel regression for restoration and reconstruction of images from sparse noisy data

Journal Article Proceedings - International Conference on Image Processing, ICIP · December 1, 2006 We introduce a class of robust non-parametric estimation methods which are ideally suited for the reconstruction of signals and images from noise-corrupted or sparsely collected samples. The filters derived from this class are locally adapted kernels which ... Full text Cite

Multi-scale statistical detection and ballistic imaging through turbid media

Journal Article Proceedings - International Conference on Image Processing, ICIP · December 1, 2006 We exploit recent advances in the physical design of fast optical systems which enable active imaging with "ballistic" light. In this modality, fast bursts of optical energy are propagated into a medium, and the ballistic component of light (which travels ... Full text Cite

Regularized kernel regression for image deblurring

Journal Article Conference Record - Asilomar Conference on Signals, Systems and Computers · December 1, 2006 The framework of kernel regression [1], a non-parametric estimation method, has been widely used in different guises for solving a variety of image processing problems including denoising and interpolation [2]. In this paper, we extend the use of kernel re ... Full text Cite

A practical approach to super-resolution

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · May 1, 2006 Theoretical and practical limitations usually constrain the achievable resolution of any imaging device. Super-Resolution (SR) methods are developed through the years to go beyond this limit by acquiring and fusing several low-resolution (LR) images of the ... Full text Cite

Video-to-video dynamic super-resolution for grayscale and color sequences

Journal Article Eurasip Journal on Applied Signal Processing · April 19, 2006 We address the dynamic super-resolution (SR) problem ofreconstructing a high-quality set of monochromatic or colorsuper-resolved images from low-quality monochromatic, color, ormosaiced frames. Our approach includes a joint method forsimultaneous SR, deblu ... Full text Cite

Multiframe demosaicing and super-resolution of color images.

Journal Article IEEE Trans Image Process · January 2006 In the last two decades, two related categories of problems have been studied independently in image restoration literature: super-resolution and demosaicing. A closer look at these problems reveals the relation between them, and, as conventional color dig ... Full text Link to item Cite

Image denoising by adaptive kernel regression

Journal Article Conference Record - Asilomar Conference on Signals, Systems and Computers · December 1, 2005 This paper introduces an extremely robust adaptive denoising filter in the spatial domain. The filter is based on non-parametric statistical estimation methods, and in particular generalizes an adaptive method proposed earlier by Fukunaga [1]. To denoise a ... Cite

Constrained, globally optimal, multi-frame motion estimation

Journal Article IEEE Workshop on Statistical Signal Processing Proceedings · January 1, 2005 We address the problem of estimating the relative motion between the frames of a video sequence. In comparison with the commonly applied pairwise image registration methods, we consider global consistency conditions for the overall multi-frame motion estim ... Full text Cite

Dynamic demosaicing and color super-resolution of video sequences

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · December 1, 2004 In the last two decades a variety of super-resolution (SR) methods have been proposed. These methods usually address the problem of fusing a set of monochromatic images to produce a single monochromatic image with higher spatial resolution. In this paper w ... Full text Cite

Multi-frame demosaicing and super-resolution from under-sampled color images

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · December 1, 2004 In the last two decades, two related categories of problems have been studied independently in the image restoration literature: super-resolution and demosaicing. A closer look at these problems reveals the relation between them, and as conventional color ... Full text Cite

Fast and robust multiframe super resolution.

Journal Article IEEE transactions on image processing : a publication of the IEEE Signal Processing Society · October 2004 Featured Publication Super-resolution reconstruction produces one or a set of high-resolution images from a set of low-resolution images. In the last two decades, a variety of super-resolution methods have been proposed. These methods are usually very sensitive to their assume ... Full text Cite

Advances and challenges in super-resolution

Journal Article International Journal of Imaging Systems and Technology · September 27, 2004 Super-Resolution reconstruction produces one or a set of high-resolution images from a sequence of low-resolution frames. This article reviews a variety of Super-Resolution methods proposed in the last 20 years, and provides some insight into, and a summar ... Full text Cite

Fast and robust super-resolution

Journal Article IEEE International Conference on Image Processing · December 17, 2003 In the last two decades, many papers have been published, proposing a variety methods of multi-frame resolution enhancement. These methods are usually very sensitive to their assumed model of data and noise, which limits their utility. This paper reviews s ... Cite

Robust Shift and Add Approach to Super-Resolution

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · December 1, 2003 In the last two decades, many papers have been published, proposing a variety of methods for multi-frame resolution enhancement. These methods, which have a wide range of complexity, memory and time requirements, are usually very sensitive to their assumed ... Full text Cite

Prediction of lupus nephritis in patients with systemic lupus erythematosus using artificial neural networks.

Journal Article Lupus · January 2002 Artificial neural networks are intelligent systems that have been successfully used for prediction in different medical fields. In this study, efficiency of neural networks for prediction of lupus nephritis in patients with systemic lupus erythematosus (SL ... Full text Cite