Kathleen Anne Welsh-Bohmer

Journal Article J Neuropsychol · September 2025 Harmonized neuropsychological assessment for neurocognitive disorders (NCDs) is an urgent priority in clinics. Neuropsychology assessments in NCDs seldom include tests exploring social cognitive skills. In 2022, we launched the SIGNATURE initiative to opti ... Full text Link to item Cite

Bayesian integration of longitudinal and survival outcomes in Alzheimer's disease prediction.

Journal Article Alzheimers Dement · September 2025 INTRODUCTION: Accurate prediction of Alzheimer's disease (AD) dementia onset and progression to mild cognitive impairment (MCI) is crucial for early intervention and clinical trial design. This study presents a predictive framework leveraging Bayesian mode ... Full text Open Access Link to item Cite

Scheltens rating scores of white matter are predictive of language function among older adults with dementia.

Journal Article Appl Neuropsychol Adult · April 4, 2025 OBJECTIVE: Examine the correlation between a visual rating of white matter integrity and common measures of language function in older adults from the Cache County Memory Study (CCMS) legacy data. METHODS: Scheltens Ratings scores of white matter were calc ... Full text Link to item Cite

Star-shaped TDP-43 inclusions in the oldest-old.

Journal Article Journal of neuropathology and experimental neurology · April 2025 Full text Cite

Scheltens ratings, clinical white matter hyperintensities and executive functioning in the Cache County Memory Study.

Journal Article Appl Neuropsychol Adult · 2025 OBJECTIVE: Examine the association between neuropsychologically assessed executive function and clinically identifiable white matter burden from magnetic resonance imaging, using a visual rating system (Scheltens Rating System) applied to the Cache County ... Full text Link to item Cite

The evaluation of the Jigsawdio program on the cognitive and mental health of people living with dementia: Mixed methods study

Journal Article Gerontechnology · January 1, 2025 Introduction: Jigsawdio is a multi-sensory personalized puzzle system that blends images and audio to stimulate cognitive function and emotional well-being in people living with dementia. This pilot study was designed to provide evidence of the effect of t ... Full text Cite

Clinical Manifestations

Journal Article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 1, 2024 BACKGROUND: Interventional trials in Alzheimer's Disease (AD) are increasingly targeting early disease stages. To optimize the likelihood of successful outcomes for these trials, there is an important need for tools capable of identifying individuals prone ... Full text Cite

Clinical Manifestations

Journal Article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 1, 2024 BACKGROUND: The impact of knowledge of β-amyloid status on cognitively unimpaired persons' cognitive test performance is unknown. METHOD: Cognitively unimpaired adults aged 65-80 with a first-degree relative with AD received a dementia risk estimate and we ... Full text Cite

Patient and Care Partner Perspective on Potential Undertreatment of Patients With Mild Cognitive Impairment for Cardiovascular Disease.

Journal Article J Appl Gerontol · November 2024 BACKGROUND AND OBJECTIVES: Mild cognitive impairment (MCI) affects up to 22% of US older adults aged 65 and older. Research suggests that physicians may recommend less cardiovascular disease (CVD) treatment for older adults with MCI due to assumptions abou ... Full text Link to item Cite

Cognitive and Cerebrospinal Fluid Alzheimer's Disease-related Biomarker Trajectories in Older Surgical Patients and Matched Nonsurgical Controls.

Conference Anesthesiology · May 1, 2024 BACKGROUND: Anesthesia and/or surgery accelerate Alzheimer's disease pathology and cause memory deficits in animal models, yet there is a lack of prospective data comparing cerebrospinal fluid (CSF) Alzheimer's disease-related biomarker and cognitive traje ... Full text Link to item Cite

Investigating the impact of immersive virtual reality meditation on coherence achievement score, anxiety, and depression among people living with dementia

Journal Article Journal of Health and Social Sciences · March 15, 2024 Introduction: Non-immersive technology-based mindfulness meditation programs have been shown to effectively reduce stress and improve users' mental health. Still, little research has been conducted to assess the health benefits of an immersive virtual real ... Full text Cite

Assessing tilavonemab efficacy in early Alzheimer's disease via longitudinal item response theory modeling.

Journal Article Alzheimers Dement (N Y) · 2024 INTRODUCTION: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by declines in cognitive and functional severities. This research utilized the Clinical Dementia Rating (CDR) to assess the influence of tilavonemab on these deterioration ... Full text Open Access Link to item Cite

Feasibility of a standard cognitive assessment in European academic memory clinics.

Journal Article Alzheimers Dement · June 2023 INTRODUCTION: Standardized cognitive assessment would enhance diagnostic reliability across memory clinics. An expert consensus adapted the Uniform Dataset (UDS)-3 for European centers, the clinician's UDS (cUDS). This study assessed its implementation acc ... Full text Link to item Cite

Influence of mild cognitive impairment on patient and care partner decision-making for acute ischemic stroke.

Journal Article J Stroke Cerebrovasc Dis · June 2023 GOALS: Evidence suggests that patients with mild cognitive impairment (MCI) receive fewer treatments for acute ischemic stroke and other cardiovascular diseases than patients with normal cognition. Little is known about how patient and care partner prefere ... Full text Link to item Cite

Meta-Analysis of Variations in Association between APOE ɛ4 and Alzheimer's Disease and Related Dementias Across Hispanic Regions of Origin.

Journal Article J Alzheimers Dis · 2023 BACKGROUND: Emerging research has shown racial and ethnic variations in the magnitude of association between the apolipoprotein ɛ4 (APOE ɛ4) allele and the risk of developing Alzheimer's disease and related dementias (ADRD). Studies researching this associ ... Full text Link to item Cite

Genotypic Effects of the TOMM40'523 Variant and APOE on Longitudinal Cognitive Change over 4 Years: The TOMMORROW Study.

Journal Article J Prev Alzheimers Dis · 2023 BACKGROUND: The 523 poly-T length polymorphism (rs10524523) in TOMM40 has been reported to influence longitudinal cognitive test performance within APOE ε3/3 carriers. The results from prior studies are inconsistent. It is also unclear whether specific APO ... Full text Open Access Link to item Cite

TOMM40 '523 Genotype Distinguishes Patterns of Cognitive Improvement for Executive Function in APOEɛ3 Homozygotes.

Journal Article J Alzheimers Dis · 2023 BACKGROUND: TOMM40 '523 has been associated with cognitive performance and risk for developing Alzheimer's disease independent of the effect of APOE genotype. Few studies have considered the longitudinal effect of this genotype on change in cognition over ... Full text Link to item Cite

Decision making in clinical trials: Interim analyses, innovative design, and biomarkers.

Journal Article Alzheimers Dement (N Y) · 2023 The efficient and accurate execution of clinical trials testing novel treatments for Alzheimer's disease (AD) is a critical component of the field's collective efforts to develop effective disease-modifying treatments for AD. The lengthy and heterogeneous ... Full text Link to item Cite

Putting participants and study partners FIRST when clinical trials end early.

Journal Article Alzheimers Dement · December 2022 Between 2018 and 2019, multiple clinical trials ended earlier than planned, resulting in calls to improve communication with and support for participants and their study partners ("dyads"). The multidisciplinary Participant Follow-Up Improvement in Researc ... Full text Link to item Cite

Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer's disease.

Journal Article Commun Biol · October 8, 2022 Dysregulation of sphingomyelin and ceramide metabolism have been implicated in Alzheimer's disease. Genome-wide and transcriptome-wide association studies have identified various genes and genetic variants in lipid metabolism that are associated with Alzhe ... Full text Link to item Cite

The Association Between Mild Cognitive Impairment Diagnosis and Patient Treatment Preferences: a Survey of Older Adults.

Journal Article J Gen Intern Med · June 2022 BACKGROUND: Older patients (65+) with mild cognitive impairment (MCI) receive less guideline-concordant care for cardiovascular disease (CVD) and other conditions than patients with normal cognition (NC). One potential explanation is that patients with MCI ... Full text Link to item Cite

Acoustofluidic multimodal diagnostic system for Alzheimer's disease.

Journal Article Biosens Bioelectron · January 15, 2022 Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative brain disorder that affects tens of millions of older adults worldwide and has significant economic and societal impacts. Despite its prevalence and severity, early diagnosis of A ... Full text Link to item Cite

A Mixed-Methods Study of the Impact of Mild Cognitive Impairment Diagnosis on Patient and Care Partner Perception of Health Risks.

Journal Article J Alzheimers Dis · 2022 BACKGROUND: Older patients (≥65 years) with mild cognitive impairment (MCI) are undertreated for cardiovascular disease (CVD). One reason for this disparity could be that patients with MCI might underestimate the chances of CVD and overestimate dementia. O ... Full text Link to item Cite

Raising Awareness of Alzheimer's Disease and Dementia in Native Americans in North Carolina.

Journal Article N C Med J · 2022 Full text Link to item Cite

Adjudicating Mild Cognitive Impairment Due to Alzheimer's Disease as a Novel Endpoint Event in the TOMMORROW Prevention Clinical Trial.

Journal Article J Prev Alzheimers Dis · 2022 BACKGROUND: The onset of mild cognitive impairment (MCI) is an essential outcome in Alzheimer's disease (AD) prevention trials and a compelling milestone for clinically meaningful change. Determining MCI, however, may be variable and subject to disagreemen ... Full text Link to item Cite

Remote self-administration of digital cognitive tests using the Brief Assessment of Cognition: Feasibility, reliability, and sensitivity to subjective cognitive decline.

Journal Article Front Psychiatry · 2022 Cognitive impairment is a common and pervasive feature of etiologically diverse disorders of the central nervous system, and a target indication for a growing number of symptomatic and disease modifying drugs. Remotely acquired digital endpoints have been ... Full text Link to item Cite

Recruitment of a multi-site randomized controlled trial of aerobic exercise for older adults with amnestic mild cognitive impairment: The EXERT trial.

Journal Article Alzheimers Dement · November 2021 INTRODUCTION: Effective strategies to recruit older adults with mild cognitive impairment (MCI) into nonpharmacological intervention trials are lacking. METHODS: Recruitment for EXERT, a multisite randomized controlled 18-month trial examining the effects ... Full text Link to item Cite

Safety and efficacy of pioglitazone for the delay of cognitive impairment in people at risk of Alzheimer's disease (TOMMORROW): a prognostic biomarker study and a phase 3, randomised, double-blind, placebo-controlled trial.

Journal Article Lancet Neurol · July 2021 BACKGROUND: The identification of people at risk of cognitive impairment is essential for improving recruitment in secondary prevention trials of Alzheimer's disease. We aimed to test and qualify a biomarker risk assignment algorithm (BRAA) to identify par ... Full text Link to item Cite

Assessment of Neuropsychological Function in Veterans With Blast-Related Mild Traumatic Brain Injury and Subconcussive Blast Exposure.

Journal Article Frontiers in psychology · January 2021 Objective: The majority of combat-related head injuries are associated with blast exposure. While Veterans with mild traumatic brain injury (mTBI) report cognitive complaints and exhibit poorer neuropsychological performance, there is little evidenc ... Full text Cite

Racially diverse participant registries to facilitate the recruitment of African Americans into presymptomatic Alzheimer's disease studies.

Journal Article Alzheimers Dement · August 2020 INTRODUCTION: The Alzheimer's Disease Prevention Registry (ADPR) of the Joseph and Kathleen Bryan Alzheimer's Disease Research Center at Duke University has been successful in achieving a racially diverse and "research ready" cohort of cognitively healthy ... Full text Link to item Cite

Longer Term Effects of Diet and Exercise on Neurocognition: 1-Year Follow-up of the ENLIGHTEN Trial.

Journal Article J Am Geriatr Soc · March 2020 OBJECTIVES: To evaluate the longer term changes in executive functioning among participants with cardiovascular disease (CVD) risk factors and cognitive impairments with no dementia (CIND) randomized to a diet and exercise intervention. DESIGN: A 2 (Exerci ... Full text Link to item Cite

Metabolic and Neurocognitive Changes Following Lifestyle Modification: Examination of Biomarkers from the ENLIGHTEN Randomized Clinical Trial.

Journal Article J Alzheimers Dis · 2020 BACKGROUND: Previous studies have demonstrated that aerobic exercise (AE) and the Dietary Approaches to Stop Hypertension (DASH) diet can improve neurocognition. However, the mechanisms by which lifestyle improves neurocognition have not been widely studie ... Full text Link to item Cite

Differentiating among stages of cognitive impairment in aging: Version 3 of the Uniform Data Set (UDS) neuropsychological test battery and MoCA index scores.

Journal Article Alzheimers Dement (N Y) · 2020 INTRODUCTION: Federally funded Alzheimer's Disease Centers in the United States have been using a standardized neuropsychological test battery as part of the National Alzheimer's Coordinating Center Uniform Data Set (UDS) since 2005. Version 3 (V3) of the ... Full text Link to item Cite

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Journal Article Nat Genet · September 2019 An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Full text Link to item Cite

Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype.

Journal Article JAMA Neurol · September 1, 2019 IMPORTANCE: Previous genome-wide association studies of common variants identified associations for Alzheimer disease (AD) loci evident only among individuals with particular APOE alleles. OBJECTIVE: To identify APOE genotype-dependent associations with in ... Full text Link to item Cite

Nomenclature for Perioperative Cognitive Disorders: Comment.

Journal Article Anesthesiology · August 2019 Full text Link to item Cite

CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease.

Journal Article Aging Cell · August 2019 CpG-related single nucleotide polymorphisms (CGS) have the potential to perturb DNA methylation; however, their effects on Alzheimer disease (AD) risk have not been evaluated systematically. We conducted a genome-wide association study using a sliding-wind ... Full text Link to item Cite

Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.

Journal Article Anesthesiology · June 2019 BACKGROUND: Cognitive decline after cardiac surgery occurs frequently and persists in a significant proportion of patients. Preclinical studies and human trials suggest that intravenous lidocaine may confer protection in the setting of neurologic injury. I ... Full text Open Access Link to item Cite

A blood-based signature of cerebrospinal fluid Aβ1-42 status.

Journal Article Sci Rep · March 11, 2019 It is increasingly recognized that Alzheimer's disease (AD) exists before dementia is present and that shifts in amyloid beta occur long before clinical symptoms can be detected. Early detection of these molecular changes is a key aspect for the success of ... Full text Link to item Cite

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Journal Article Nat Genet · March 2019 Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We confi ... Full text Link to item Cite

A statistical framework for cross-tissue transcriptome-wide association analysis.

Journal Article Nat Genet · March 2019 Transcriptome-wide association analysis is a powerful approach to studying the genetic architecture of complex traits. A key component of this approach is to build a model to impute gene expression levels from genotypes by using samples with matched genoty ... Full text Link to item Cite

Lifestyle and neurocognition in older adults with cognitive impairments: A randomized trial.

Journal Article Neurology · January 15, 2019 OBJECTIVE: To determine the independent and additive effects of aerobic exercise (AE) and the Dietary Approaches to Stop Hypertension (DASH) diet on executive functioning in adults with cognitive impairments with no dementia (CIND) and risk factors for car ... Full text Link to item Cite

MRI Clinical Ratings and Cognitive Function in a Cross-Sectional Population Study of Dementia: The Cache County Memory Study.

Journal Article J Prev Alzheimers Dis · 2019 BACKGROUND: White matter integrity in aging populations is associated with increased risk of cognitive decline, dementia diagnosis, and mortality. Population-based data can elucidate this association. OBJECTIVES: To examine the association between white ma ... Full text Link to item Cite

Combination Therapy for Alzheimer's Disease: Perspectives of the EU/US CTAD Task Force.

Journal Article J Prev Alzheimers Dis · 2019 Combination therapy is expected to play an important role for the treatment of Alzheimer's disease (AD). In October 2018, the European Union-North American Clinical Trials in Alzheimer's Disease Task Force (EU/US CTAD Task Force) met to discuss scientific, ... Full text Link to item Cite

Effects of pioglitazone on mnemonic hippocampal function: A blood oxygen level-dependent functional magnetic resonance imaging study in elderly adults.

Journal Article Alzheimers Dement (N Y) · 2019 INTRODUCTION: Mitochondrial dysfunction is implicated in the pathophysiology of Alzheimer's disease (AD). Accordingly, drugs that positively influence mitochondrial function are being evaluated in delay-of-onset clinical trials with at-risk individuals. Su ... Full text Link to item Cite

Association Between Insulin Resistance, Plasma Leptin, and Neurocognition in Vascular Cognitive Impairment.

Journal Article J Alzheimers Dis · 2019 BACKGROUND: Greater body weight has been associated impairments in neurocognition and greater dementia risk, although the mechanisms linking weight and neurocognition have yet to be adequately delineated. OBJECTIVE: To examine metabolic mechanisms underlyi ... Full text Link to item Cite

The TOMMORROW study: Design of an Alzheimer's disease delay-of-onset clinical trial.

Journal Article Alzheimers Dement (N Y) · 2019 INTRODUCTION: Alzheimer's disease (AD) is a continuum with neuropathologies manifesting years before clinical symptoms; thus, AD research is attempting to identify more disease-modifying approaches to test treatments administered before full disease expres ... Full text Link to item Cite

Sex-specific genetic predictors of Alzheimer's disease biomarkers.

Journal Article Acta Neuropathol · December 2018 Cerebrospinal fluid (CSF) levels of amyloid-β 42 (Aβ42) and tau have been evaluated as endophenotypes in Alzheimer's disease (AD) genetic studies. Although there are sex differences in AD risk, sex differences have not been evaluated in genetic studies of ... Full text Link to item Cite

Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau.

Journal Article JAMA Neurol · August 1, 2018 IMPORTANCE: The strongest genetic risk factor for Alzheimer disease (AD), the apolipoprotein E (APOE) gene, has a stronger association among women compared with men. Yet limited work has evaluated the association between APOE alleles and markers of AD neur ... Full text Link to item Cite

Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults.

Journal Article Hum Brain Mapp · February 2018 OBJECTIVES: Older adults often display postoperative cognitive decline (POCD) after surgery, yet it is unclear to what extent functional connectivity (FC) alterations may underlie these deficits. We examined for postoperative voxel-wise FC changes in respo ... Full text Open Access Link to item Cite

Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS).

Journal Article Alzheimer Dis Assoc Disord · 2018 INTRODUCTION: The neuropsychological battery of the Uniform Data Set (UDSNB) was implemented in 2005 by the National Institute on Aging (NIA) Alzheimer Disease Centers program to measure cognitive performance in dementia and mild cognitive impairment due t ... Full text Link to item Cite

Measuring cognition and function in the preclinical stage of Alzheimer's disease.

Journal Article Alzheimers Dement (N Y) · 2018 The Alzheimer's Association's Research Roundtable met in November 2016 to explore how best to measure changes in cognition and function in the preclinical stage of Alzheimer's disease. This review will cover the tools and instruments currently available to ... Full text Link to item Cite

Dual-Task Gait and Alzheimer's Disease Genetic Risk in Cognitively Normal Adults: A Pilot Study.

Journal Article J Alzheimers Dis · 2018 BACKGROUND: Dual-task paradigms, in which an individual performs tasks separately and then concurrently, often demonstrate that people with neurodegenerative disorders experience more dual-task interference, defined as worse performance in the dual-task co ... Full text Link to item Cite

TOMMORROW neuropsychological battery: German language validation and normative study.

Journal Article Alzheimers Dement (N Y) · 2018 INTRODUCTION: Assessment of preclinical Alzheimer's disease (AD) requires reliable and validated methods to detect subtle cognitive changes. The battery of standardized cognitive assessments that is used for diagnostic criteria for mild cognitive impairmen ... Full text Link to item Cite

Assessment of Instrumental Activities of Daily Living in Older Adults with Subjective Cognitive Decline Using the Virtual Reality Functional Capacity Assessment Tool (VRFCAT).

Journal Article J Prev Alzheimers Dis · 2018 BACKGROUND: Continuing advances in the understanding of Alzheimer's disease progression have inspired development of disease-modifying therapeutics intended for use in preclinical populations. However, identification of clinically meaningful cognitive and ... Full text Link to item Cite

Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease

Journal Article Alzheimer S and Dementia Diagnosis Assessment and Disease Monitoring · January 1, 2018 Introduction: There is conflicting evidence whether high-density lipoprotein cholesterol (HDL-C) is a risk factor for Alzheimer's disease (AD) and dementia. Genetic variation in the cholesteryl ester transfer protein (CETP) locus is associated with altered ... Full text Cite

A computerized, self-administered test of verbal episodic memory in elderly patients with mild cognitive impairment and healthy participants: A randomized, crossover, validation study.

Journal Article Alzheimers Dement (Amst) · 2018 INTRODUCTION: Performance of "Revere", a novel iPad-administered word-list recall (WLR) test, in quantifying deficits in verbal episodic memory, was evaluated versus examiner-administered Rey Auditory Verbal Learning Test (RAVLT) in patients with mild cogn ... Full text Link to item Cite

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.

Journal Article Nat Genet · September 2017 We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 × 10-4) ... Full text Link to item Cite

Transethnic genome-wide scan identifies novel Alzheimer's disease loci.

Journal Article Alzheimers Dement · July 2017 INTRODUCTION: Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood. METHODS: We conducted a transethnic genome-wide association study (G ... Full text Link to item Cite

Resting-State Functional Connectivity and Cognition After Major Cardiac Surgery in Older Adults without Preoperative Cognitive Impairment: Preliminary Findings.

Journal Article J Am Geriatr Soc · January 2017 OBJECTIVES: To look for changes in intrinsic functional brain connectivity associated with postoperative changes in cognition, a common complication in seniors undergoing major surgery, using resting-state functional magnetic resonance imaging. DESIGN: Obj ... Full text Open Access Link to item Cite

Lifestyle and Neurocognition in Older Adults With Cardiovascular Risk Factors and Cognitive Impairment.

Journal Article Psychosom Med · 2017 OBJECTIVE: The aim of the study was to determine the relationship of lifestyle factors and neurocognitive functioning in older adults with vascular risk factors and cognitive impairment, no dementia (CIND). METHODS: One hundred sixty adults (M [SD] = 65.4 ... Full text Link to item Cite

EU/US/CTAD Task Force: Lessons Learned from Recent and Current Alzheimer's Prevention Trials.

Conference J Prev Alzheimers Dis · 2017 At a meeting of the EU/US/Clinical Trials in Alzheimer's Disease (CTAD) Task Force in December 2016, an international group of investigators from industry, academia, and regulatory agencies reviewed lessons learned from ongoing and planned prevention trial ... Full text Link to item Cite

New Genetic Approaches to AD: Lessons from APOE-TOMM40 Phylogenetics.

Journal Article Curr Neurol Neurosci Rep · May 2016 Clinical trials for Alzheimer's disease are now focusing on the earliest stages of the disease with the goal of delaying dementia onset. There is great utility in using genetic variants to identify individuals at high age-dependent risk when the goal is to ... Full text Link to item Cite

Assessment of the genetic variance of late-onset Alzheimer's disease.

Journal Article Neurobiol Aging · May 2016 Alzheimer's disease (AD) is a complex genetic disorder with no effective treatments. More than 20 common markers have been identified, which are associated with AD. Recently, several rare variants have been identified in Amyloid Precursor Protein (APP), Tr ... Full text Link to item Cite

Collaboration for Alzheimer's Prevention: Principles to guide data and sample sharing in preclinical Alzheimer's disease trials.

Journal Article Alzheimers Dement · May 2016 Full text Link to item Cite

Association of traumatic brain injury with subsequent neurological and psychiatric disease: a meta-analysis.

Journal Article J Neurosurg · February 2016 OBJECTIVE: Mild traumatic brain injury (TBI) has been proposed as a risk factor for the development of Alzheimer's disease, Parkinson's disease, depression, and other illnesses. This study's objective was to determine the association of prior mild TBI with ... Full text Link to item Cite

CAP--advancing the evaluation of preclinical Alzheimer disease treatments.

Journal Article Nat Rev Neurol · January 2016 If we are to find treatments to postpone, reduce the risk of, or completely prevent the clinical onset of Alzheimer disease (AD), we need faster methods to evaluate promising preclinical AD treatments, new ways to work together in support of common goals, ... Full text Link to item Cite

Prefrontal contributions to relational encoding in amnestic mild cognitive impairment.

Journal Article Neuroimage Clin · 2016 Relational memory declines are well documented as an early marker for amnestic mild cognitive impairment (aMCI). Episodic memory formation relies on relational processing supported by two mnemonic mechanisms, generation and binding. Neuroimaging studies us ... Full text Link to item Cite

Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci.

Journal Article PLoS One · 2016 Late onset Alzheimer's disease (LOAD) is a genetically complex and clinically heterogeneous disease. Recent large-scale genome wide association studies (GWAS) have identified more than twenty loci that modify risk for AD. Despite the identification of thes ... Full text Link to item Cite

A Genetics-based Biomarker Risk Algorithm for Predicting Risk of Alzheimer's Disease.

Journal Article Alzheimers Dement (N Y) · January 1, 2016 BACKGROUND: A straightforward, reproducible blood-based test that predicts age dependent risk of Alzheimer's disease (AD) could be used as an enrichment tool for clinical development of therapies. This study evaluated the prognostic performance of a geneti ... Full text Link to item Cite

Results From the NACC Uniform Data Set Neuropsychological Battery Crosswalk Study.

Journal Article Alzheimer Dis Assoc Disord · 2016 INTRODUCTION: Four new nonproprietary tests were recommended for use in the National Alzheimer's Coordinating Center's Uniform Data Set Neuropsychological Battery. These tests are similar to previous tests but also allow for continuity of longitudinal data ... Full text Link to item Cite

A novel Alzheimer disease locus located near the gene encoding tau protein.

Journal Article Mol Psychiatry · January 2016 APOE ɛ4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer's Project (IGAP) Consortium in APOE ɛ4+ (10 ... Full text Link to item Cite

Validation of a Novel Computerized Self-Administered Memory-Screening Test With Automated Reporting (SAMSTAR) in Patients With Mild Cognitive Impairment and Normal Control Participants: A Randomized, Crossover, Controlled Study

Conference NEUROPSYCHOPHARMACOLOGY · 2016 Cite

Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses.

Journal Article Alzheimers Dement · December 2015 Observational research shows that higher body mass index (BMI) increases Alzheimer's disease (AD) risk, but it is unclear whether this association is causal. We applied genetic variants that predict BMI in Mendelian randomization analyses, an approach that ... Full text Link to item Cite

Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals.

Journal Article JAMA Neurol · November 2015 IMPORTANCE: Mutations in known causal Alzheimer disease (AD) genes account for only 1% to 3% of patients and almost all are dominantly inherited. Recessive inheritance of complex phenotypes can be linked to long (>1-megabase [Mb]) runs of homozygosity (ROH ... Full text Link to item Cite

Considering the base rates of low performance in cognitively healthy older adults improves the accuracy to identify neurocognitive impairment with the Consortium to Establish a Registry for Alzheimer’s Disease-Neuropsychological Assessment Battery (CERAD-NAB)

Journal Article European Archives of Psychiatry and Clinical Neuroscience · August 12, 2015 It is common for some healthy older adults to obtain low test scores when a battery of neuropsychological tests is administered, which increases the risk of the clinician misdiagnosing cognitive impairment. Thus, base rates of healthy individuals’ low scor ... Full text Cite

Cognitive Function: Is There More to Anticoagulation in Atrial Fibrillation Than Stroke?

Journal Article J Am Heart Assoc · August 3, 2015 Full text Open Access Link to item Cite

Considering the base rates of low performance in cognitively healthy older adults improves the accuracy to identify neurocognitive impairment with the Consortium to Establish a Registry for Alzheimer's Disease-Neuropsychological Assessment Battery (CERAD-NAB).

Journal Article Eur Arch Psychiatry Clin Neurosci · August 2015 It is common for some healthy older adults to obtain low test scores when a battery of neuropsychological tests is administered, which increases the risk of the clinician misdiagnosing cognitive impairment. Thus, base rates of healthy individuals' low scor ... Full text Link to item Cite

Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study.

Journal Article PLoS Med · June 2015 BACKGROUND: Potentially modifiable risk factors including obesity, diabetes, hypertension, and smoking are associated with Alzheimer disease (AD) and represent promising targets for intervention. However, the causality of these associations is unclear. We ... Full text Link to item Cite

Rarity of the Alzheimer disease-protective APP A673T variant in the United States.

Journal Article JAMA Neurol · February 2015 IMPORTANCE: Recently, a rare variant in the amyloid precursor protein gene (APP) was described in a population from Iceland. This variant, in which alanine is replaced by threonine at position 673 (A673T), appears to protect against late-onset Alzheimer di ... Full text Link to item Cite

A Pharmacogenetics Supported Clinical Trial to Delay Onset of Mild Cognitive Impairment due to Alzheimer's Disease Using Low Dose Pioglitazone: The Tommorrow Study

Conference NEUROPSYCHOPHARMACOLOGY · December 1, 2014 Link to item Cite

A comparison of neuropsychological performance between US and Russia: preparing for a global clinical trial.

Journal Article Alzheimers Dement · November 2014 BACKGROUND: Understanding regional differences in cognitive performance is important for interpretation of data from large multinational clinical trials. METHODS: Data from Durham and Cabarrus Counties in North Carolina, USA and Tomsk, Russia (n = 2972) we ... Full text Link to item Cite

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.

Journal Article JAMA Neurol · November 2014 IMPORTANCE: Because APOE locus variants contribute to risk of late-onset Alzheimer disease (LOAD) and to differences in age at onset (AAO), it is important to know whether other established LOAD risk loci also affect AAO in affected participants. OBJECTIVE ... Full text Link to item Cite

African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles.

Journal Article Alzheimers Dement · November 2014 BACKGROUND: Several studies have demonstrated a lower apolipoprotein E4 (APOE ε4) allele frequency in African-Americans, but yet an increased age-related prevalence of AD. An algorithm for prevention clinical trials incorporating TOMM40'523 (Translocase of ... Full text Link to item Cite

Use of diuretics is associated with reduced risk of Alzheimer's disease: the Cache County Study.

Journal Article Neurobiol Aging · November 2014 Although the use of antihypertensive medications has been associated with reduced risk of Alzheimer's disease (AD), it remains unclear which class provides the most benefit. The Cache County Study of Memory Health and Aging is a prospective longitudinal co ... Full text Link to item Cite

Impact of offspring death on cognitive health in late life: the Cache County study.

Journal Article Am J Geriatr Psychiatry · November 2014 OBJECTIVE: Experiencing the death of a child is associated with negative short-term mental health consequences, but less is known about cognitive outcomes and whether such associations extend to late life. We tested the hypothesis that experiencing an offs ... Full text Link to item Cite

Pre-clinical cognitive phenotypes for Alzheimer disease: a latent profile approach.

Journal Article Am J Geriatr Psychiatry · November 2014 BACKGROUND: Cognitive profiles for pre-clinical Alzheimer disease (AD) can be used to identify groups of individuals at risk for disease and better characterize pre-clinical disease. Profiles or patterns of performance as pre-clinical phenotypes may be mor ... Full text Link to item Cite

The genetic contributions of SNCA and LRRK2 genes to Lewy Body pathology in Alzheimer's disease.

Journal Article Hum Mol Genet · September 15, 2014 The molecular genetic basis that leads to Lewy Body (LB) pathology in 15-20% of Alzheimer disease cases (LBV/AD) was largely unknown. Alpha-synuclein (SNCA) and Leucine-rich repeat kinase2 (LRRK2) have been implicated in the pathogenesis of Parkinson's dis ... Full text Link to item Cite

The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes.

Journal Article Alzheimers Dement · September 2014 BACKGROUND: We investigated the genomic region spanning the Translocase of the Outer Mitochondrial Membrane 40-kD (TOMM40) and Apolipoprotein E (APOE) genes, that has been associated with the risk and age of onset of late-onset Alzheimer's disease (LOAD) t ... Full text Link to item Cite

Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: the Cache County Dementia Progression Study.

Journal Article Alzheimers Dement · May 2014 BACKGROUND: Single-nucleotide polymorphisms (SNPs) located in the gene encoding the regulatory subunit of the protein phosphatase 2B (PPP3R1, rs1868402) and the microtubule-associated protein tau (MAPT, rs3785883) gene were recently associated with higher ... Full text Link to item Cite

Vascular risk factors and neuropsychiatric symptoms in Alzheimer's disease: the Cache County Study.

Journal Article Int J Geriatr Psychiatry · February 2014 OBJECTIVE: Knowledge of potentially modifiable risk factors for neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) is important. This study longitudinally explores modifiable vascular risk factors for NPS in AD. METHODS: Participants enrolled in t ... Full text Link to item Cite

Community engagement in diverse populations for Alzheimer disease prevention trials.

Journal Article Alzheimer Dis Assoc Disord · 2014 The recruitment of asymptomatic volunteers has been identified as a critical factor that is delaying the development and validation of preventive therapies for Alzheimer disease (AD). Typical recruitment strategies involve the use of convenience samples or ... Full text Link to item Cite

Neuropsychiatric symptoms as risk factors for progression from CIND to dementia: the Cache County Study.

Journal Article Am J Geriatr Psychiatry · November 2013 OBJECTIVES: To examine the association of neuropsychiatric symptom (NPS) severity with risk of transition to all-cause dementia, Alzheimer disease (AD), and vascular dementia (VaD). DESIGN: Survival analysis of time to dementia, AD, or VaD onset. SETTING: ... Full text Link to item Cite

Prospective study of Dietary Approaches to Stop Hypertension- and Mediterranean-style dietary patterns and age-related cognitive change: the Cache County Study on Memory, Health and Aging.

Journal Article Am J Clin Nutr · November 2013 BACKGROUND: Healthy dietary patterns may protect against age-related cognitive decline, but results of studies have been inconsistent. OBJECTIVE: We examined associations between Dietary Approaches to Stop Hypertension (DASH)- and Mediterranean-style dieta ... Full text Link to item Cite

Stressful life events and cognitive decline in late life: moderation by education and age. The Cache County Study.

Journal Article Int J Geriatr Psychiatry · August 2013 OBJECTIVE: Stressful life events (SLE) have been associated with increased dementia risk, but their association with cognitive decline has been inconsistent. In a longitudinal population-based study of older individuals, we examined the association between ... Full text Link to item Cite

Phenotypic regional functional imaging patterns during memory encoding in mild cognitive impairment and Alzheimer's disease.

Journal Article Alzheimers Dement · May 2013 BACKGROUND: Reliable blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) phenotypic biomarkers of Alzheimer's disease (AD) or mild cognitive impairment (MCI) are likely to emerge only from a systematic, quantitative, and aggreg ... Full text Open Access Link to item Cite

Albert Heyman, MD (1916–2012)

Journal Article Neurology · March 26, 2013 Full text Cite

Neuropsychological predictors of dementia in late-life major depressive disorder.

Journal Article Am J Geriatr Psychiatry · March 2013 OBJECTIVE: Major depressive disorder is a likely risk factor for dementia, but some cases of major depressive disorder in older adults may actually represent a prodrome of this condition. The purpose of this study was to use neuropsychological test scores ... Full text Link to item Cite

Using genetics to enable studies on the prevention of Alzheimer's disease.

Journal Article Clin Pharmacol Ther · February 2013 Curing Alzheimer's disease (AD) remains an elusive goal; indeed, it may even prove to be impossible, given the nature of the disease. Although modulating disease progression is an attractive target and will alleviate the burden of the most severe stages, t ... Full text Link to item Cite

PREFRONTAL CONTRIBUTIONS TO RELATIONAL ENCODING IN HEALTHY AGING AND MILD COGNITIVE IMPAIRMENT

Conference JOURNAL OF COGNITIVE NEUROSCIENCE · January 1, 2013 Open Access Link to item Cite

Can lifestyle modification improve neurocognition? Rationale and design of the ENLIGHTEN clinical trial.

Journal Article Contemp Clin Trials · January 2013 BACKGROUND: Risk factors for cardiovascular disease (CVD) not only increase the risk for clinical CVD events, but also are associated with a cascade of neurophysiologic and neuroanatomic changes that increase the risk of cognitive impairment and dementia. ... Full text Link to item Cite

Separation of cognitive domains to improve prediction of progression from mild cognitive impairment to Alzheimer's disease.

Journal Article Alzheimers Res Ther · 2013 Addressing causes of heterogeneity in cognitive outcomes is becoming more critical as Alzheimer's disease (AD) research focuses on earlier disease. One of the causes of this heterogeneity may be that individuals with deficiencies in different cognitive dom ... Full text Link to item Cite

The association of psychotropic medication use with the cognitive, functional, and neuropsychiatric trajectory of Alzheimer's disease.

Journal Article Int J Geriatr Psychiatry · December 2012 OBJECTIVE: The use of psychotropic medications in Alzheimer's disease (AD) has been associated with both deleterious and potentially beneficial outcomes. We examined the longitudinal association of psychotropic medication use with cognitive, functional, an ... Full text Link to item Cite

Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.

Journal Article Nat Genet · December 2012 Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were assoc ... Full text Link to item Cite

Treatment course with antidepressant therapy in late-life depression.

Journal Article Am J Psychiatry · November 2012 OBJECTIVE: In order to assess the effect of gray matter volumes and cortical thickness on antidepressant treatment response in late-life depression, the authors examined the relationship between brain regions identified a priori and Montgomery-Åsberg Depre ... Full text Link to item Cite

Hormone therapy and Alzheimer disease dementia: new findings from the Cache County Study.

Journal Article Neurology · October 30, 2012 OBJECTIVES: Observational studies suggest reduced risk of Alzheimer disease (AD) in users of hormone therapy (HT), but trials show higher risk. We examined whether the association of HT with AD varies with timing or type of HT use. METHODS: Between 1995 an ... Full text Link to item Cite

Effects of general medical health on Alzheimer's progression: the Cache County Dementia Progression Study.

Journal Article Int Psychogeriatr · October 2012 BACKGROUND: Several observational studies have suggested a link between health status and rate of decline among individuals with Alzheimer's disease (AD). We sought to quantify the relationship in a population-based study of incident AD, and to compare glo ... Full text Link to item Cite

Neuropsychiatric Symptoms as Risk Factors for Progression From CIND to Dementia: The Cache County Study.

Journal Article Am J Geriatr Psychiatry · September 12, 2012 OBJECTIVES:: To examine the association of neuropsychiatric symptom (NPS) severity with risk of transition to all-cause dementia, Alzheimer disease (AD), and vascular dementia (VaD). DESIGN:: Survival analysis of time to dementia, AD, or VaD onset. SETTING ... Full text Link to item Cite

Event-related functional magnetic resonance imaging changes during relational retrieval in normal aging and amnestic mild cognitive impairment.

Journal Article J Int Neuropsychol Soc · September 2012 The earliest cognitive deficits observed in amnestic mild cognitive impairment (aMCI) appear to center on memory tasks that require relational memory (RM), the ability to link or integrate unrelated pieces of information. RM impairments in aMCI likely refl ... Full text Link to item Cite

A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging.

Journal Article Alzheimers Dement · September 2012 INTRODUCTION: A highly polymorphic T homopolymer was recently found to be associated with late-onset Alzheimer's disease risk and age of onset. OBJECTIVE: To explore the effects of the polymorphic polyT tract (rs10524523, referred as '523') on cognitive pe ... Full text Link to item Cite

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases.

Journal Article Hum Mol Genet · August 1, 2012 Rare mutations in the gene encoding for tau (MAPT, microtubule-associated protein tau) cause frontotemporal dementia-spectrum (FTD-s) disorders, including FTD, progressive supranuclear palsy (PSP) and corticobasal syndrome, and a common extended haplotype ... Full text Link to item Cite

Cognitive improvement following treatment in late-life depression: relationship to vascular risk and age of onset.

Journal Article Am J Geriatr Psychiatry · August 2012 OBJECTIVES: To test the hypothesis that the degree of vascular burden and/or age of onset may influence the degree to which cognition can improve during the course of treatment in late-life depression. DESIGN: Measurement of cognition both before and follo ... Full text Link to item Cite

The Alzheimer's associated 5' region of the SORL1 gene cis regulates SORL1 transcripts expression.

Journal Article Neurobiol Aging · July 2012 SORL1 has been identified as a major contributor to late onset Alzheimer's disease (LOAD). We test whether genetic variability in the 5' of SORL1 gene modulates the risk to develop LOAD via regulation of SORL1-messenger ribonucleic acid (mRNA) expression a ... Full text Link to item Cite

Prevalence of neuropsychiatric symptoms in CIND and its subtypes: the Cache County Study.

Journal Article Am J Geriatr Psychiatry · May 2012 OBJECTIVES: 1) To report rates of neuropsychiatric symptoms (NPS) in cognitive impairment, no dementia (CIND). 2) To compare the 30-day prevalence of NPS in CIND with that in dementia and cognitively normal individuals. 3) To compare the prevalence of NPS ... Full text Link to item Cite

Effects of Food and Drug Administration-approved medications for Alzheimer's disease on clinical progression.

Journal Article Alzheimers Dement · May 2012 BACKGROUND: Observational studies suggest that cholinesterase inhibitors and/or memantine may delay clinical progression of Alzheimer's disease (AD) in 40% of individuals taking the medications. Given this response and existence of side effects, we sought ... Full text Link to item Cite

PSYCHOSOCIAL STRESS IN MIDLIFE MAY MODERATE EFFECTS OF APOE-TOMM40 RS157580 ON METABOLIC TRAITS IN LATE LIFE

Journal Article ANNALS OF BEHAVIORAL MEDICINE · April 1, 2012 Link to item Cite

Neuropsychological Predictors of Dementia in Late-Life Major Depressive Disorder.

Journal Article Am J Geriatr Psychiatry · March 11, 2012 OBJECTIVE:: Major depressive disorder is a likely risk factor for dementia, but some cases of major depressive disorder in older adults may actually represent a prodrome of this condition. The purpose of this study was to use neuropsychological test scores ... Full text Link to item Cite

Lifestyle behavior pattern is associated with different levels of risk for incident dementia and Alzheimer's disease: the Cache County study.

Journal Article J Am Geriatr Soc · March 2012 OBJECTIVES: To identify distinct behavioral patterns of diet, exercise, social interaction, church attendance, alcohol consumption, and smoking and to examine their association with subsequent dementia risk. DESIGN: Longitudinal, population-based dementia ... Full text Link to item Cite

Identification of MCI individuals using structural and functional connectivity networks.

Journal Article Neuroimage · February 1, 2012 Different imaging modalities provide essential complementary information that can be used to enhance our understanding of brain disorders. This study focuses on integrating multiple imaging modalities to identify individuals at risk for mild cognitive impa ... Full text Link to item Cite

Epidemiology of cognitive aging and Alzheimer's disease: contributions of the cache county utah study of memory, health and aging.

Journal Article Curr Top Behav Neurosci · 2012 Epidemiological studies of Alzheimer's disease (AD) provide insights into changing public health trends and their contribution to disease incidence. The current chapter considers how the population-based approach has contributed to our understanding of lif ... Full text Link to item Cite

Resting-state multi-spectrum functional connectivity networks for identification of MCI patients.

Journal Article PLoS One · 2012 In this paper, a high-dimensional pattern classification framework, based on functional associations between brain regions during resting-state, is proposed to accurately identify MCI individuals from subjects who experience normal aging. The proposed tech ... Full text Link to item Cite

Characterization of the poly-T variant in the TOMM40 gene in diverse populations.

Journal Article PLoS One · 2012 We previously discovered that a polymorphic, deoxythymidine-homopolymer (poly-T, rs10524523) in intron 6 of the TOMM40 gene is associated with age-of-onset of Alzheimer's disease and with cognitive performance in elderly. Three allele groups were defined f ... Full text Link to item Cite

Pervasive olfactory impairment after bilateral limbic system destruction.

Journal Article J Clin Exp Neuropsychol · 2012 What pattern of brain damage could completely obliterate the sense of olfaction in humans? We had an opportunity to address this intriguing question in Patient B., who has extensive bilateral damage to most of the limbic system, including the medial and la ... Full text Link to item Cite

Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study.

Journal Article Neurobiol Aging · December 2011 Many elderly individuals remain dementia-free throughout their life. However, some of these individuals exhibit Alzheimer disease neuropathology on autopsy, evidenced by neurofibrillary tangles (NFTs) in AD-specific brain regions. We conducted a genome-wid ... Full text Link to item Cite

Norms for CERAD constructional praxis recall.

Journal Article Clin Neuropsychol · November 2011 Recall of the four-item constructional praxis measure was a later addition to the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological battery. Norms for this measure, based on cognitively intact African Americans age ≥70 ( ... Full text Link to item Cite

Early parental death and remarriage of widowed parents as risk factors for Alzheimer disease: the Cache County study.

Journal Article Am J Geriatr Psychiatry · September 2011 OBJECTIVES: Early parental death is associated with lifelong tendencies toward depression and chronic stress. We tested the hypothesis that early parental death is associated with higher risk for Alzheimer disease (AD) in offspring. DESIGN: A population-ba ... Full text Link to item Cite

Incidence of dementia and cognitive impairment, not dementia in the United States.

Journal Article Ann Neurol · September 2011 OBJECTIVE: Estimates of incident dementia, and cognitive impairment, not dementia (CIND) (or the related mild cognitive impairment) are important for public health and clinical care policy. In this paper, we report US national incidence rates for dementia ... Full text Link to item Cite

Cognitive stimulation and cognitive and functional decline in Alzheimer's disease: the cache county dementia progression study.

Journal Article J Gerontol B Psychol Sci Soc Sci · July 2011 OBJECTIVES: To examine the association of engagement in cognitively stimulating activities with cognitive and functional decline in a population-based sample of incident Alzheimer's disease (AD). METHOD: After diagnosis, 187 participants (65% females) were ... Full text Link to item Cite

Utility of a simple algorithm to grade diastolic dysfunction and predict outcome after coronary artery bypass graft surgery.

Journal Article Ann Thorac Surg · June 2011 BACKGROUND: Inclusion of a measure of left ventricular diastolic dysfunction (LVDD) may improve risk prediction after cardiac surgery. Current LVDD grading guidelines rely on echocardiographic variables that are not always available or aligned to allow gra ... Full text Link to item Cite

Progression of cognitive, functional, and neuropsychiatric symptom domains in a population cohort with Alzheimer dementia: the Cache County Dementia Progression study.

Journal Article Am J Geriatr Psychiatry · June 2011 OBJECTIVES: Progression of Alzheimer dementia (AD) is highly variable. Most estimates derive from convenience samples from dementia clinics or research centers where there is substantial potential for survival bias and other distortions. In a population-ba ... Full text Link to item Cite

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Journal Article Nat Genet · May 2011 The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two replication stages (stages 2 and 3). Both joint analysis ... Full text Link to item Cite

Metabolomic changes in autopsy-confirmed Alzheimer's disease.

Journal Article Alzheimers Dement · May 2011 BACKGROUND: Metabolomics, the global science of biochemistry, provides powerful tools to map perturbations in the metabolic network and enables simultaneous quantification of several metabolites to identify metabolic perturbances that might provide insight ... Full text Link to item Cite

Intracranial volume and dementia: some evidence in support of the cerebral reserve hypothesis.

Journal Article Brain Res · April 18, 2011 The brain reserve hypothesis has been posited as being one important mediating factor for developing dementia, especially Alzheimer's disease (AD). Evidence for this hypothesis is mixed though different methodologies have made these findings difficult to i ... Full text Link to item Cite

The effect of SNCA 3' region on the levels of SNCA-112 splicing variant.

Journal Article Neurogenetics · February 2011 Genetic variability at the 3' region of SNCA locus has been repeatedly associated with susceptibility to sporadic Parkinson's disease (PD). Accumulated evidence emphasizes the importance of SNCA dosage and expression levels in PD pathogenesis. However, the ... Full text Link to item Cite

Enriched white matter connectivity networks for accurate identification of MCI patients.

Journal Article Neuroimage · February 1, 2011 Mild cognitive impairment (MCI), often a prodromal phase of Alzheimer's disease (AD), is frequently considered to be a good target for early diagnosis and therapeutic interventions of AD. Recent emergence of reliable network characterization techniques has ... Full text Link to item Cite

INDIVIDUAL RELIGIOUS BEHAVIORS ARE INVERSELY ASSOCIATED WITH SUBSEQUENT GERIATRIC DEPRESSION

Conference GERONTOLOGIST · 2011 Cite

Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 1.

Journal Article Alzheimers Dement · January 2011 In this article, the challenges faced by several noted population studies for Alzheimer dementia in operationalizing current clinical diagnostic criteria for Alzheimer's disease (AD) have been reviewed. Differences in case ascertainment, methodological bia ... Full text Link to item Cite

Factor structure of the National Alzheimer's Coordinating Centers uniform dataset neuropsychological battery: an evaluation of invariance between and within groups over time.

Journal Article Alzheimer Dis Assoc Disord · 2011 The neuropsychological battery from the National Alzheimer's Disease Coordinating Center is designed to provide a sensitive assessment of mild cognitive disorders for multicenter investigations. Comprising 8 common neuropsychological tests (12 measures), t ... Full text Link to item Cite

Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics.

Journal Article PLoS One · 2011 BACKGROUND: The development of plasma biomarkers could facilitate early detection, risk assessment and therapeutic monitoring in Alzheimer's disease (AD). Alterations in ceramides and sphingomyelins have been postulated to play a role in amyloidogensis and ... Full text Link to item Cite

Cognitive Domains Affected by Conditions of Ageing and the Role of Neuropsychological Testing

Journal Article · December 2, 2010 Determining the presence of a memory disorder in older patients can be challenging given the similarity between the complaints of benign brain aging and early brain diseases, such as Alzheimer's disease. In this chapter is we provide an overview of the cog ... Full text Cite

Accurate identification of MCI patients via enriched white-matter connectivity network

Journal Article Lecture Notes in Computer Science Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics · October 25, 2010 Mild cognitive impairment (MCI), often a prodromal phase of Alzheimer's disease (AD), is frequently considered to be a good target for early diagnosis and therapeutic interventions of AD. Recent emergence of reliable network characterization techniques hav ... Full text Cite

A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease.

Journal Article Pharmacogenomics J · October 2010 The ɛ4 allele of the apolipoprotein E (APOE) gene is currently the strongest and most highly replicated genetic factor for risk and age of onset of late-onset Alzheimer's disease (LOAD). Using phylogenetic analysis, we have identified a polymorphic poly-T ... Full text Link to item Cite

TIMING OF OFFSPRING DEATH IN PARENTS' LIVES AND LATE-LIFE COGNITIVE DECLINE. THE CACHE COUNTY STUDY

Journal Article GERONTOLOGIST · October 1, 2010 Link to item Cite

FAMILY SIZE MODERATES THE ASSOCIATION BETWEEN OFFSPRING DEATH AND RATE OF COGNITIVE DECLINE. THE CACHE COUNTY STUDY

Journal Article GERONTOLOGIST · October 1, 2010 Link to item Cite

STRESSFUL EVENTS IN LATE-LIFE: EFFECTS ON COGNITIVE DECLINE. THE CACHE COUNTY STUDY

Journal Article GERONTOLOGIST · October 1, 2010 Link to item Cite

Apolipoprotein E ε4 status and cognitive decline with and without dementia - Reply

Journal Article Archives of Neurology · August 1, 2010 Full text Cite

Temporal lobe functional activity and connectivity in young adult APOE varepsilon4 carriers.

Journal Article Alzheimers Dement · July 2010 BACKGROUND: We sought to determine if the APOE epsilon4 allele influences both the functional activation and connectivity of the medial temporal lobes (MTLs) during successful memory encoding in young adults. METHODS: Twenty-four healthy young adults, i.e. ... Full text Link to item Cite

A brief metacognition questionnaire for the elderly: comparison with cognitive performance and informant ratings the Cache County Study.

Journal Article Int J Geriatr Psychiatry · July 2010 OBJECTIVE: To examine the utility of a brief, metacognition questionnaire by examining its association with objective cognitive testing and informant ratings. We hypothesized that the association between self-ratings of change and both outcomes would be gr ... Full text Link to item Cite

Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure.

Journal Article Hypertension · June 2010 High blood pressure increases the risks of stroke, dementia, and neurocognitive dysfunction. Although aerobic exercise and dietary modifications have been shown to reduce blood pressure, no randomized trials have examined the effects of aerobic exercise co ... Full text Open Access Link to item Cite

Occupational exposure to pesticides increases the risk of incident AD: the Cache County study.

Journal Article Neurology · May 11, 2010 BACKGROUND: Commonly used organophosphate and organochlorine pesticides inhibit acetylcholinesterase at synapses in the somatic, autonomic, and central nervous systems and may therefore have lasting effects on the nervous system. Few studies have examined ... Full text Link to item Cite

Greater risk of dementia when spouse has dementia? The Cache County study.

Journal Article J Am Geriatr Soc · May 2010 OBJECTIVES: To examine the effects of caring for a spouse with dementia on the caregiver's risk for incident dementia. DESIGN: Population-based study of incident dementia in spouses of persons with dementia. SETTING: Rural county in northern Utah. PARTICIP ... Full text Link to item Cite

Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials.

Journal Article Psychosom Med · April 2010 OBJECTIVES: To assess the effects of aerobic exercise training on neurocognitive performance. Although the effects of exercise on neurocognition have been the subject of several previous reviews and meta-analyses, they have been hampered by methodological ... Full text Open Access Link to item Cite

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.

Journal Article Nat Genet · March 2010 Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia. The predominant neuropathology is FTLD with TAR DNA-binding protein (TDP-43) inclusions (FTLD-TDP). FTLD-TDP is frequently familial, resulting from mutations in ... Full text Link to item Cite

Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial.

Journal Article Arch Gen Psychiatry · March 2010 CONTEXT: Research on vascular depression has used 2 approaches to subtype late-life depression, based on executive dysfunction or white matter hyperintensity severity. OBJECTIVE: To evaluate the relationship of neuropsychological performance and white matt ... Full text Link to item Cite

Support for the Vascular Depression Hypothesis in Late-Life Depression: Results of a 2-Site, Prospective, Antidepressant Treatment Trial (vol 67, pg 277, 2010)

Journal Article ARCHIVES OF GENERAL PSYCHIATRY · 2010 Cite

Association between APOE epsilon4 allele and vascular dementia: The Cache County study.

Journal Article Dement Geriatr Cogn Disord · 2010 BACKGROUND: The APOE epsilon4 allele is an established risk factor for Alzheimer's disease, but reports of its association with vascular dementia (VaD) have been inconsistent. We examined the relationship between APOE epsilon4 allele and the risk of incide ... Full text Link to item Cite

Genome-wide scan of copy number variation in late-onset Alzheimer's disease.

Journal Article J Alzheimers Dis · 2010 Alzheimer's disease is a complex and progressive neurodegenerative disease leading to loss of memory, cognitive impairment, and ultimately death. To date, six large-scale genome-wide association studies have been conducted to identify SNPs that influence d ... Full text Open Access Link to item Cite

Genetic and environmental contributions to cognitive decline in aging and Alzheimer's disease

Journal Article Annual Review of Gerontology and Geriatrics · January 1, 2010 Inheritance appears to play a strong role in terms of human longevity and also in risk for chronic neurodegenerative diseases of late life such as Alzheimer's disease (AD). Understanding the role of genes in normal biological aging of the nervous system an ... Full text Cite

Executive Measures are Related to Functional Ability in an Ethnically Diverse Cohort

Journal Article CLINICAL NEUROPSYCHOLOGIST · January 1, 2010 Link to item Cite

Effects of family history and apolipoprotein E epsilon4 status on cognitive decline in the absence of Alzheimer dementia: the Cache County Study.

Journal Article Arch Neurol · November 2009 OBJECTIVE: To evaluate the influences of a family history of Alzheimer dementia (FHxAD) and the apolipoprotein E epsilon4 genotype (APOE epsilon4) on cognitive decline. DESIGN, SETTING, AND PARTICIPANTS: Residents of Cache County, Utah, aged 65 years or ol ... Full text Link to item Cite

Genetic regulation of alpha-synuclein mRNA expression in various human brain tissues.

Journal Article PLoS One · October 16, 2009 Genetic variability across the SNCA locus has been repeatedly associated with susceptibility to sporadic Parkinson's disease (PD). Accumulated evidence emphasizes the importance of SNCA dosage and expression levels in PD pathogenesis. However whether genet ... Full text Link to item Cite

The COMT Val158Met polymorphism and cognition in depressed and nondepressed older adults.

Journal Article Int J Geriatr Psychiatry · October 2009 OBJECTIVE: The objective of the current study was to examine the relationship between the COMT Val(158)Met polymorphism and neuropsychological performance in depressed and nondepressed older adults. METHODS: One hundred and twenty-six clinically depressed ... Full text Link to item Cite

Caregiver-recipient closeness and symptom progression in Alzheimer disease. The Cache County Dementia Progression Study.

Journal Article J Gerontol B Psychol Sci Soc Sci · September 2009 Applying Rusbult's investment model of dyadic relationships, we examined the effect of caregiver-care recipient relationship closeness (RC) on cognitive and functional decline in Alzheimer's disease. After diagnosis, 167 participants completed up to six vi ... Full text Link to item Cite

Genetic aspects of behavioral neurotoxicology.

Journal Article Neurotoxicology · September 2009 Considerable progress has been made over the past couple of decades concerning the molecular bases of neurobehavioral function and dysfunction. The field of neurobehavioral genetics is becoming mature. Genetic factors contributing to neurologic diseases su ... Full text Link to item Cite

Cerebrovascular smooth muscle actin is increased in nondemented subjects with frequent senile plaques at autopsy: implications for the pathogenesis of Alzheimer disease.

Journal Article J Neuropathol Exp Neurol · April 2009 We previously found that vascular smooth muscle actin (SMA) is reduced in the brains of patients with late stage Alzheimer disease (AD) compared with brains of nondemented, neuropathologically normal subjects. To assess the pathogenetic significance and di ... Full text Link to item Cite

Neuropsychological correlates of magnetic resonance imaging-defined subcortical ischemic depression.

Journal Article Int J Geriatr Psychiatry · March 2009 OBJECTIVE: The goal of the current study was to examine the neuropsychological profile of magnetic resonance imaging (MRI)-defined subcortical ischemic depression (SID). METHODS: Clinically depressed older adults with MRI-defined SID (n = 70) and depressed ... Full text Link to item Cite

Age Moderates the Effect of Late-life Depression on Incident Alzheimer's Disease Risk

Conference AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · March 1, 2009 Link to item Cite

Alzheimer disease: what changes in the brain cause dementia?

Journal Article Neurology · January 27, 2009 Full text Link to item Cite

Prevalence of Neuropsychiatric Symptoms in CIND and its Subtypes: Cache County Study

Conference AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · 2009 Cite

Neuropsychological performance in advanced age: influences of demographic factors and Apolipoprotein E: findings from the Cache County Memory Study.

Journal Article Clin Neuropsychol · January 2009 The Cache County Study of Memory in Aging (CCMS) is an epidemiological study of Alzheimer's disease (AD), mild cognitive disorders, and aging in a population of exceptionally long-lived individuals (7th to 11th decade). Observation of population members wi ... Full text Link to item Cite

Tissue-specific genetic control of splicing: implications for the study of complex traits.

Journal Article PLoS Biol · December 23, 2008 Numerous genome-wide screens for polymorphisms that influence gene expression have provided key insights into the genetic control of transcription. Despite this work, the relevance of specific polymorphisms to in vivo expression and splicing remains unclea ... Full text Open Access Link to item Cite

Effects of cardiovascular medications on rate of functional decline in Alzheimer disease.

Journal Article Am J Geriatr Psychiatry · November 2008 BACKGROUND: Evidence suggests that cardiovascular medications, including statins and antihypertensive medications, may delay cognitive decline in patients with Alzheimer dementia (AD). We examined the association of cardiovascular medication use and rate o ... Full text Link to item Cite

Neuropsychological characterization of dementia patients.

Journal Article CNS Spectr · October 2008 Full text Link to item Cite

Neuropsychological characterization of dementia patients

Journal Article Primary Psychiatry · October 1, 2008 Cite

Neurocognitive correlates of response to treatment in late-life depression.

Journal Article Am J Geriatr Psychiatry · September 2008 UNLABELLED: Depression is often associated with neurocognitive deficits in older adults, particularly in the domains of information processing speed, episodic memory, and executive functions. Greater neurocognitive dysfunction while depressed is associated ... Full text Link to item Cite

Longitudinal follow-up of late-onset Alzheimer disease families.

Journal Article Am J Med Genet B Neuropsychiatr Genet · July 5, 2008 Historically, data for genetic studies are collected at one time point. However, for diseases with late onset or with complex phenotypes, such as Alzheimer disease (AD), restricting diagnosis to a single ascertainment contact may not be sufficient. Affecti ... Full text Link to item Cite

No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies.

Journal Article Neurology · June 10, 2008 INTRODUCTION: Observational studies show reduced incidence of Alzheimer dementia (AD) in users of nonsteroidal anti-inflammatory drugs (NSAIDs). One hypothesis holds that the subset of NSAIDs known as selective A beta(42)-lowering agents (SALAs) is respons ... Full text Link to item Cite

Neuroanatomical correlates of malingered memory impairment: event-related fMRI of deception on a recognition memory task.

Journal Article Brain Inj · June 2008 PRIMARY OBJECTIVE: Event-related, functional magnetic resonance imaging (fMRI) data were acquired in healthy participants during purposefully malingered and normal recognition memory performances to evaluate the neural substrates of feigned memory impairme ... Full text Link to item Cite

Vascular factors and risk for neuropsychiatric symptoms in Alzheimer's disease: the Cache County Study.

Journal Article Int Psychogeriatr · June 2008 OBJECTIVE: To examine, in an exploratory analysis, the association between vascular conditions and the occurrence of neuropsychiatric symptoms (NPS) in a population-based sample of incident Alzheimer's disease (AD). METHODS: The sample consisted of 254 par ... Full text Link to item Cite

Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: the Cache County Study.

Journal Article Alzheimers Dement · May 2008 Studies have shown less cognitive decline and lower risk of Alzheimer's disease in elderly individuals consuming either antioxidant vitamins or nonsteroidal anti-inflammatory drugs (NSAIDs). The potential of added benefit from their combined use has not be ... Full text Link to item Cite

Church attendance and new episodes of major depression in a community study of older adults: the Cache County Study.

Journal Article J Gerontol B Psychol Sci Soc Sci · May 2008 We examined the relation between church attendance, membership in the Church of Jesus Christ of Latter-Day Saints (LDS), and major depressive episode, in a population-based study of aging and dementia in Cache County, Utah. Participants included 2,989 nond ... Full text Link to item Cite

Regional atrophy of the corpus callosum in dementia.

Journal Article J Int Neuropsychol Soc · May 2008 The regional distribution of degeneration of the corpus callosum (CC) in dementia is not yet clear. This study compared regional CC size in participants (n = 179) from the Cache County Memory and Aging Study. Participants represented a range of cognitive f ... Full text Link to item Cite

Consortium to Establish a Registry for Alzheimer's Disease (CERAD): the first twenty years.

Journal Article Alzheimers Dement · March 2008 The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) was funded by the National Institute on Aging in 1986 to develop standardized, validated measures for the assessment of Alzheimer's disease (AD). The present report describes the measur ... Full text Link to item Cite

Defining "prodromal" Alzheimer's disease, frontotemporal dementia, and Lewy body dementia: are we there yet?

Journal Article Neuropsychol Rev · March 2008 Full text Link to item Cite

Time of day affects episodic memory in older adults.

Journal Article Neuropsychol Dev Cogn B Aging Neuropsychol Cogn · March 2008 The neuropsychological test scores of 2030 cognitively normal older adults were examined to evaluate performance patterns as they related to time of day (TOD) at which testing was initiated. Multiple regression analyses were used to examine the association ... Full text Link to item Cite

Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study.

Journal Article Int J Geriatr Psychiatry · February 2008 BACKGROUND: Neuropsychiatric symptoms are nearly universal in dementia, yet little is known about their longitudinal course in the community. OBJECTIVE: To estimate point and 5-year period prevalence of neuropsychiatric symptoms in an incident sample of 40 ... Full text Link to item Cite

Tissue-specific genetic control of splicing: Implications for the study of complex traits

Journal Article PLoS Biology · 2008 Numerous genome-wide screens for polymorphisms that influence gene expression have provided key insights into the genetic control of transcription. Despite this work, the relevance of specific polymorphisms to in vivo expression and splicing remains unclea ... Full text Cite

Neuropsychological characterization of dementia patients

Journal Article CNS Spectrums · 2008 Cite

Postmortem delay has minimal effect on brain RNA integrity.

Journal Article J Neuropathol Exp Neurol · December 2007 The Bryan Alzheimer Disease Research Center obtains postmortem human brain tissue from patients with Alzheimer disease (AD) and cognitively normal control subjects for molecular and genetic research programs. A growing body of research suggests that variat ... Full text Link to item Cite

Vascular factors predict rate of progression in Alzheimer disease.

Journal Article Neurology · November 6, 2007 BACKGROUND: While there is considerable epidemiologic evidence that cardiovascular risk factors increase risk of incident Alzheimer disease (AD), few studies have examined their effect on progression after an established AD diagnosis. OBJECTIVE: To examine ... Full text Link to item Cite

Longitudinal magnetic resonance imaging vascular changes, apolipoprotein E genotype, and development of dementia in the neurocognitive outcomes of depression in the elderly study.

Journal Article Am J Geriatr Psychiatry · October 2007 OBJECTIVE: Several studies suggest that depression is a risk factor for development of dementia in the elderly. In a study of older depressed individuals, the authors examined both neuroimaging and genetic factors in development of dementia. The authors hy ... Full text Link to item Cite

Prefrontal white matter lesions and prefrontal task impersistence in depressed and nondepressed elders.

Journal Article Neuropsychopharmacology · October 2007 Poor task persistence is often observed among depressed individuals, and may be associated with some of the same frontal regions that are involved in depression. The current study explored the association between white-matter lesion volume in prefrontal co ... Full text Link to item Cite

Does NSAID use modify cognitive trajectories in the elderly? The Cache County study.

Journal Article Neurology · July 17, 2007 BACKGROUND: Epidemiologic studies have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) may be useful for the prevention of Alzheimer disease (AD). By contrast, clinical trials have not supported NSAID use to delay or treat AD. Few studies have ... Full text Link to item Cite

Autopsy-confirmed Alzheimer's disease versus clinically diagnosed Alzheimer's disease in the Cache County Study on Memory and Aging: a comparison of quantitative MRI and neuropsychological findings.

Journal Article J Clin Exp Neuropsychol · July 2007 Atrophy of specific, regional, and generalized brain structures occurs as a result of the Alzheimer's disease (AD) process. Comparing AD patients with histopathological confirmation of the disease at autopsy to those without autopsy but who were clinically ... Full text Link to item Cite

Epidemiology of apathy in older adults: the Cache County Study.

Journal Article Am J Geriatr Psychiatry · May 2007 OBJECTIVES: The objectives of this study are to describe the distribution of apathy in community-based older adults and to investigate its relationships with cognition and day-to-day functioning. METHODS: Data from the Cache County Study on Memory, Health ... Full text Link to item Cite

Arteriolar ApoE expression is increased Alzheimer disease cortex

Conference Journal of Neuropathology and Experimental Neurology · May 2007 Full text Cite

Proxies and consent discussions for dementia research.

Journal Article J Am Geriatr Soc · April 2007 OBJECTIVES: To better understand the nature of informed consent encounters for research involving patients with dementia that requires proxy consent. DESIGN: Audiotaping of informed-consent encounters for a study of genetic markers for sporadic Alzheimer's ... Full text Link to item Cite

Arteriolar ApoE expression is increased Alzheimer disease cortex.

Conference FASEB JOURNAL · April 1, 2007 Link to item Cite

Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers.

Journal Article Neurology · February 6, 2007 Full text Link to item Cite

Risk of mortality with vitamin E supplements: the Cache County study.

Journal Article Am J Med · February 2007 PURPOSE: A recent meta-analysis reported increased mortality in clinical trial participants randomized to high-dose vitamin E. We sought to determine whether these mortality risks with vitamin E reflect adverse consequences of its use in the presence of ca ... Full text Link to item Cite

Persistent mild cognitive impairment in geriatric depression.

Journal Article Int Psychogeriatr · February 2007 BACKGROUND: Cognitive impairment often occurs with geriatric depression and impairments may persist despite remission of depression. Although clinical definitions of mild cognitive impairment (MCI) have typically excluded depression, a neuropsychological m ... Full text Link to item Cite

Antioxidant intake and cognitive function of elderly men and women: the Cache County Study.

Journal Article J Nutr Health Aging · 2007 OBJECTIVE: We prospectively examined associations between intakes of antioxidants (vitamins C, vitamin E, and carotene) and cognitive function and decline among elderly men and women of the Cache County Study on Memory and Aging in Utah. PARTICIPANTS AND D ... Link to item Cite

The distribution of cerebrovascular amyloid in Alzheimer's disease varies with ApoE genotype.

Journal Article Acta Neuropathol · January 2007 We performed a comparative study to assess cerebral amyloid angiopathy and ApoE genotype in cases of Alzheimer's disease (AD). Ten ApoE 3,3 and ten ApoE 4,4 AD brains, as well as ten normal control brains, were selected after matching for age, sex, and dur ... Full text Link to item Cite

Alternative ion channel splicing in mesial temporal lobe epilepsy and Alzheimer's disease.

Journal Article Genome Biol · 2007 BACKGROUND: Alternative gene transcript splicing permits a single gene to produce multiple proteins with varied functions. Bioinformatic investigations have identified numerous splice variants, but whether these transcripts are translated to functional pro ... Full text Link to item Cite

The National Alzheimer's Coordinating Center (NACC) database: the Uniform Data Set.

Journal Article Alzheimer Dis Assoc Disord · 2007 The National Alzheimer's Coordinating Center (NACC) is responsible for developing and maintaining a database of participant information collected from the 29 Alzheimer's Disease Centers (ADCs) funded by the National Institute on Aging (NIA). The NIA appoin ... Full text Link to item Cite

Duke Twins Study of Memory in Aging in the NAS-NRC Twin Registry.

Journal Article Twin Res Hum Genet · December 2006 The Duke Twins Study of Memory in Aging is an ongoing, longitudinal study of cognitive change and dementia in the population-based National Academy of Sciences-National Research Council (NAS-NRC) Twin Registry of World War II Male Veterans. The primary goa ... Full text Link to item Cite

Antihypertensive medication use and incident Alzheimer disease: The cache county study

Conference NEUROPSYCHOPHARMACOLOGY · December 1, 2006 Link to item Cite

Risk factors for neuropsychiatric symptoms in dementia: the Cache County Study.

Journal Article Int J Geriatr Psychiatry · September 2006 OBJECTIVE: To investigate the probability of individual neuropsychiatric symptoms in dementia patients as a function of eight risk factors. METHODS: In the Cache County Study, we administered the Neuropsychiatric Inventory (NPI) to 328 dementia patients at ... Full text Link to item Cite

Human brain tissue may be retrieved up to 30 hours post-mortem with little effect on RNA or protein integrity

Conference BRAIN PATHOLOGY · September 1, 2006 Link to item Cite

Central nervous system injury associated with cardiac surgery.

Journal Article Lancet · August 19, 2006 Millions of individuals with coronary artery or valvular heart disease have been given a new chance at life by heart surgery, but the potential for neurological injury is an Achilles heel. Technological advancements and innovations in surgical and anaesthe ... Full text Link to item Cite

Revealing the role of glutathione S-transferase omega in age-at-onset of Alzheimer and Parkinson diseases.

Journal Article Neurobiol Aging · August 2006 We previously reported a linkage region on chromosome 10q for age-at-onset (AAO) of Alzheimer (AD) and Parkinson (PD) diseases. Glutathione S-transferase, omega-1 (GSTO1) and the adjacent gene GSTO2, located in this linkage region, were then reported to as ... Full text Link to item Cite

Conversion to dementia from mild cognitive disorder: the Cache County Study.

Journal Article Neurology · July 25, 2006 OBJECTIVE: To examine 3-year rates of conversion to dementia, and risk factors for such conversion, in a population-based sample with diverse types of cognitive impairment. METHODS: All elderly (aged 65 or older) residents of Cache County, UT, were invited ... Full text Link to item Cite

Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease.

Journal Article Neurology · July 11, 2006 BACKGROUND: Previous linkage studies have shown that chromosome 12 harbors susceptibility genes for late-onset Alzheimer disease (LOAD). However, association studies of several candidate genes on this chromosome region have produced ambiguous results. A re ... Full text Link to item Cite

Modifying dementia risk and trajectories of cognitive decline in aging: the Cache County Memory Study.

Journal Article Alzheimers Dement · July 2006 The Cache County Study of Memory, Health, and Aging, more commonly referred to as the "Cache County Memory Study (CCMS)" is a longitudinal investigation of aging and Alzheimer's disease (AD) based in an exceptionally long-lived population residing in north ... Full text Link to item Cite

Genetic association between endothelial nitric oxide synthase and Alzheimer disease.

Journal Article Clin Genet · July 2006 Evidence suggests that vascular and inflammatory factors may be important in the etiology of Alzheimer disease (AD). The Glu/Glu genotype at the Glu298Asp variant of the endothelial nitric oxide synthase (NOS3) gene has been tested for association with AD ... Full text Link to item Cite

Parsing the genetic heterogeneity of chromosome 12q susceptibility genes for Alzheimer disease by family-based association analysis.

Journal Article Neurogenetics · July 2006 Previous linkage studies have suggested that chromosome 12 may harbor susceptibility genes for late-onset Alzheimer disease (LOAD). No risk genes on chromosome 12 have been conclusively identified yet. We have reported that the linkage evidence for LOAD in ... Full text Link to item Cite

Cognitive function in late life depression: relationships to depression severity, cerebrovascular risk factors and processing speed.

Journal Article Biol Psychiatry · July 1, 2006 BACKGROUND: A number of studies have examined clinical factors linked to worse neuropsychological performance in late life depression (LLD). To understand the influence of LLD on cognition, it is important to determine if deficits in a number of cognitive ... Full text Link to item Cite

A population-based study of the association between coronary artery bypass graft surgery (CABG) and cognitive decline: the Cache County study.

Journal Article Int J Geriatr Psychiatry · June 2006 BACKGROUND: The relationship between coronary artery bypass graft (CABG) surgery and cognitive decline remains uncertain, in particular with regard to whether there is delayed cognitive decline associated with this procedure. METHODS: This was a population ... Full text Link to item Cite

Antihypertensive medication use and incident Alzheimer disease: the Cache County Study.

Journal Article Arch Neurol · May 2006 BACKGROUND: Recent reports suggest that antihypertensive (AH) medications may reduce the risk of dementing illnesses. OBJECTIVES: To examine the relationship of AH medication use with incidence of Alzheimer disease (AD) among the elderly population (aged 6 ... Full text Link to item Cite

Gender differences in the association between religious involvement and depression: the Cache County (Utah) study.

Journal Article J Gerontol B Psychol Sci Soc Sci · May 2006 We examined the relation between religious involvement, membership in the Church of Jesus Christ of Latter-Day Saints, and major depression in a population-based study of aging and dementia in Cache County, Utah. Participants included 4,468 nondemented ind ... Full text Link to item Cite

Lack of association between UBQLN1 and Alzheimer disease.

Journal Article Am J Med Genet B Neuropsychiatr Genet · April 5, 2006 Alzheimer disease (AD) is heterogeneous and complex with a strong genetic diathesis. It is the most common cause of dementia affecting the elderly. Linkage studies [Kehoe et al., 1999; Hum Mol Genet 8: 237-245]; [Pericak-Vance et al., 2000; Exp Gerontol 35 ... Full text Link to item Cite

Better cognitive performance in elderly taking vitamins E and C in combination with NSAIDs: The Cache County study

Conference NEUROLOGY · March 14, 2006 Link to item Cite

A genome-wide linkage analysis of dementia in the Amish.

Journal Article Am J Med Genet B Neuropsychiatr Genet · March 5, 2006 Susceptibility genes for Alzheimer's disease are proving to be highly challenging to detect and verify. Population heterogeneity may be a significant confounding factor contributing to this difficulty. To increase the power for disease susceptibility gene ... Full text Link to item Cite

Combinatorial Mismatch Scan (CMS) for loci associated with dementia in the Amish.

Journal Article BMC Med Genet · March 3, 2006 BACKGROUND: Population heterogeneity may be a significant confounding factor hampering detection and verification of late onset Alzheimer's disease (LOAD) susceptibility genes. The Amish communities located in Indiana and Ohio are relatively isolated popul ... Full text Link to item Cite

Three-year incidence of first-onset depressive syndrome in a population sample of older adults: the Cache County study.

Journal Article Am J Geriatr Psychiatry · March 2006 OBJECTIVE: Estimates of incidence of late-life depression vary greatly with few studies excluding demented cases through in-depth evaluation and most studies failing to control for the effect of mortality and interval treatment. In a large population-based ... Full text Link to item Cite

Ten dimensions of health and their relationships with overall self-reported health and survival in a predominately religiously active elderly population: the cache county memory study.

Journal Article J Am Geriatr Soc · February 2006 OBJECTIVES: To document the extent of healthy aging along 10 different dimensions in a population known for its longevity. DESIGN: A cohort study with baseline measures of overall self-reported health and health along 10 specific dimensions; analyses inves ... Full text Link to item Cite

Perspectives on depression, mild cognitive impairment, and cognitive decline.

Journal Article Arch Gen Psychiatry · February 2006 CONTEXT: The public health implications of depression and cognitive impairment in late life are enormous. Cognitive impairment and late-life depression are associated with increased risk for subsequent dementia; however, investigations of these phenomena a ... Full text Link to item Cite

Neuropsychological Assessment of Dementia

Chapter · January 1, 2006 Department of Psychiatry and Joseph and Kathleen Bryan Alzheimer’s Disease Research Center-Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, U.S.A. Neuropsychological assessment plays an important part i ... Full text Cite

Vascular risk factors for incident Alzheimer disease and vascular dementia: the Cache County study.

Journal Article Alzheimer Dis Assoc Disord · 2006 Vascular risk factors for Alzheimer disease (AD) and vascular dementia (VaD) have been evaluated; however, few studies have compared risks by dementia subtypes and sex. We evaluated relationships between cardiovascular risk factors (hypertension, high chol ... Full text Link to item Cite

Ascending digits task as a measure of executive function in geriatric depression.

Journal Article J Neuropsychiatry Clin Neurosci · 2006 The authors hypothesized that older depressed patients would perform more poorly on the Ascending Digits Task (ADT) when matched against a nondepressed elderly comparison group. In a novel measure, the ADT, 129 older depressives scored more poorly than 129 ... Full text Link to item Cite

Comparison of clinical and neuropathologic diagnoses of Alzheimer's disease in 3 epidemiologic samples.

Journal Article Alzheimers Dement · January 2006 BACKGROUND: Studies of dementia in populations avoid many of the selection biases in clinical samples but require special evaluation and diagnostic methods to obtain high participation rates. To address this issue, we developed a unique in-home dementia as ... Full text Link to item Cite

Polymorphisms in the PON gene cluster are associated with Alzheimer disease.

Journal Article Hum Mol Genet · January 1, 2006 Paraoxonase is an arylesterase enzyme that is expressed in the liver and found in the circulation in association with apoA1 and the high-density lipoprotein, and prevents the accumulation of oxidized lipids in low-density lipoproteins in vitro. Common poly ... Full text Link to item Cite

Exploring the effect of interactions of GAPD genes on late-onset al.zheimer disease

Conference GENETIC EPIDEMIOLOGY · November 1, 2005 Link to item Cite

Maternal lineages and Alzheimer disease risk in the Old Order Amish.

Journal Article Hum Genet · October 2005 Old Order Amish, founded by a small number of Swiss immigrants, exist in culturally isolated communities across rural North America. The consequences of genetic isolation and inbreeding within this group are evident by increased frequencies of many monogen ... Full text Link to item Cite

Population-based study of medical comorbidity in early dementia and "cognitive impairment, no dementia (CIND)": association with functional and cognitive impairment: The Cache County Study.

Journal Article Am J Geriatr Psychiatry · August 2005 OBJECTIVE: Authors investigated medical comorbidity in persons with dementia and "Cognitive Impairment, No Dementia" (CIND). METHODS: The Cache County Study is an ongoing population-based study of the epidemiology of dementia, the risk factors for conversi ... Full text Link to item Cite

Identification of VaD and AD prodromes: the Cache County Study.

Journal Article Alzheimers Dement · July 2005 BACKGROUND: It is unclear whether vascular dementia (VaD) has a cognitive prodrome, akin to the mild cognitive impairment (MCI) prodrome to Alzheimer's dementia (AD). To evaluate whether VaD has a cognitive prodrome, and if it can be differentiated from pr ... Full text Link to item Cite

Apolipoprotein E genotype and mortality: findings from the Cache County Study.

Journal Article J Am Geriatr Soc · June 2005 OBJECTIVES: To evaluate the association between apolipoprotein E (apo E) epsilon4 and mortality, the population attributable risk for mortality with epsilon4, and relative contributions of cardiovascular disease (CVD) and Alzheimer's disease (AD). DESIGN: ... Full text Link to item Cite

An autosomal genomic screen for dementia in an extended Amish family.

Journal Article Neurosci Lett · May 13, 2005 Apolipoprotein E (APOE) is the only universally confirmed susceptibility gene for late-onset Alzheimer disease (LOAD), although many loci are believed to modulate LOAD risk. The genetic homogeneity of isolated populations, such as the Amish, potentially pr ... Full text Link to item Cite

Cerebrovascular smooth muscle actin is increased in possible Azheimer disease brain tissue: A controlled autopsy study.

Journal Article JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY · May 1, 2005 Link to item Cite

Do statins reduce risk of incident dementia and Alzheimer disease? The Cache County Study.

Journal Article Arch Gen Psychiatry · February 2005 BACKGROUND: Prior reports suggest reduced occurrence of dementia and Alzheimer disease (AD) in statin users, but, to our knowledge, no prospective studies relate statin use and dementia incidence. OBJECTIVE: To examine the association of statin use with bo ... Full text Link to item Cite

Emotional enhancement of perceptual priming is preserved in aging and early-stage Alzheimer's disease.

Journal Article Neuropsychologia · 2005 Perceptual priming for emotionally-negative and neutral scenes was tested in early-stage Alzheimer's disease (AD) patients and healthy younger, middle-aged and older adults. In the study phase, participants rated the scenes for their arousal properties. In ... Full text Link to item Cite

A population study of Alzheimer's disease: findings from the Cache County Study on Memory, Health, and Aging.

Journal Article Care Manag J · 2005 There are several population-based studies of aging, memory, and dementia being conducted worldwide. Of these, the Cache County Study on Memory, Health and Aging is noteworthy for its large number of "oldest-old" members. This study, which has been followi ... Full text Link to item Cite

Age effects of coronary artery bypass graft on cognitive status change among elderly male twins.

Journal Article Neurology · December 28, 2004 BACKGROUND: Research regarding long-term cognitive outcome following coronary artery bypass graft (CABG) is inconsistent, which may be due in part to differential genetic and environmental influences within most study samples. METHODS: The authors examined ... Full text Link to item Cite

Methodology and preliminary results from the neurocognitive outcomes of depression in the elderly study.

Journal Article J Geriatr Psychiatry Neurol · December 2004 A methodology is presented for following a cohort of older depressed patients to examine neurocognitive outcomes of depression. A total of 265 depressed individuals and 138 healthy, nondepressed controls age 60 and older who completed at least 1 year of fo ... Full text Link to item Cite

Comprehensive association analysis of APOE regulatory region polymorphisms in Alzheimer disease.

Journal Article Neurogenetics · December 2004 Several recent case-control studies have examined the association between single nucleotide polymorphisms (SNPs) in the promoter region of the apolipoprotein E gene (APOE) and risk of Alzheimer disease (AD), with conflicting results. We assessed the relati ... Full text Link to item Cite

Impact of healthy aging on awareness and fear conditioning.

Journal Article Behav Neurosci · October 2004 Fear conditioning has provided a useful model system for studying associative emotional learning, but the impact of healthy aging has gone relatively unexplored. The present study investigated fear conditioning across the adult life span in humans. A delay ... Full text Link to item Cite

Analysis of European mitochondrial haplogroups with Alzheimer disease risk.

Journal Article Neurosci Lett · July 15, 2004 We examined the association of mtDNA variation with Alzheimer disease (AD) risk in Caucasians (989 cases and 328 controls) testing the effect of individual haplogroups and single nucleotide polymorphisms (SNPs). Logistic regression analyses were used to as ... Full text Link to item Cite