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Lejla Vajzovic

Associate Professor of Ophthalmology
Ophthalmology, Vitreoretinal Diseases & Surgery

Selected Publications


Repeatability and reproducibility of quantitative OCT angiography measurements from table-top and portable Flex Spectralis devices.

Journal Article Graefes Arch Clin Exp Ophthalmol · January 25, 2024 PURPOSE: The recent development of a portable investigational handheld OCT-angiography (OCTA) device has allowed for expansion of imaging into the operating room (OR) in addition to standard in-clinic imaging. The aim of this study was to assess intravisit ... Full text Link to item Cite

Longitudinal Choroidal Development in Preterm Infants.

Journal Article Ophthalmol Sci · 2024 PURPOSE: To characterize changes in subfoveal choroidal thickness in preterm infants from 30 to 60 weeks' postmenstrual age (PMA). DESIGN: The prospective, observational Study of Eye Imaging in Preterm infantS (BabySTEPS) enrolled infants eligible for reti ... Full text Link to item Cite

Transabdominal Fetal Ultrasound Before Early-Term Planned Delivery for Norrie Disease.

Journal Article J Vitreoretin Dis · 2024 Purpose: To describe a case of early-term planned delivery of a fetus with Norrie disease. Methods: A retrospective chart review was performed. Results: A fetus with an older sibling with bilateral blindness from Norrie disease had positive NPD genetic tes ... Full text Link to item Cite

Chronic Effects of e-Cigarette Aerosol Inhalation on Macular Perfusion Assessed Using OCT Angiography.

Journal Article J Vitreoretin Dis · 2024 Purpose: To determine whether there are significant differences in the microvasculature and central retinal thickness (CRT) between e-cigarette users (user group) and age-matched nonusers (control group) using optical coherence tomography angiography (OCTA ... Full text Link to item Cite

Fluocinolone Acetonide Implant Removal From the Vitreous Cavity

Journal Article Journal of VitreoRetinal Diseases · November 1, 2023 Purpose: To describe a technique for fluocinolone acetonide implant removal from the vitreous cavity. Methods: A case report and review of surgical methods were performed. Results: The technique to remove a fluocinolone acetonide implant from the vitreous ... Full text Cite

PEDIATRIC VITREORETINAL SURGERY TIPS The youngest patients require some extra care in the OR. Here’s what you need to know

Journal Article Retina Today · October 1, 2023 There are significant anatomical differences between pediatric and adult eyes that have important implications for pediatric vitreoretinal surgery. For example, posterior segment volume is less than 50% at birth, and axial length is approximately 70% compa ... Cite

NOVEL METHOD FOR VISUALIZING PERIPHERAL RETINAL STRUCTURES WITH MICROSCOPE-INTEGRATED OPTICAL COHERENCE TOMOGRAPHY.

Journal Article Retin Cases Brief Rep · July 1, 2023 BACKGROUND/PURPOSE: Visualization of peripheral retinal structures with optical coherence tomography (OCT) can be challenging but can offer valuable clinical information. We describe a method for intraoperative OCT of the peripheral retina. METHODS: An inv ... Full text Link to item Cite

Methods for real-time feature-guided image fusion of intrasurgical volumetric optical coherence tomography with digital microscopy.

Journal Article Biomed Opt Express · July 1, 2023 4D-microscope-integrated optical coherence tomography (4D-MIOCT) is an emergent multimodal imaging technology in which live volumetric OCT (4D-OCT) is implemented in tandem with standard stereo color microscopy. 4D-OCT provides ophthalmic surgeons with man ... Full text Link to item Cite

Comparison in Retreatments between Bevacizumab and Ranibizumab Intravitreal Injections for Retinopathy of Prematurity: A Multicenter Study.

Conference Ophthalmology · April 2023 PURPOSE: To compare the types and dosages of anti-vascular endothelial growth factors (VEGFs) to ascertain whether specific dosages or types of injection were associated with retreatment in clinical practice in the United States. DESIGN: Multicenter, retro ... Full text Link to item Cite

Associations between systemic health and retinal nerve fibre layer thickness in preterm infants at 36 weeks postmenstrual age.

Journal Article Br J Ophthalmol · February 2023 BACKGROUND/AIMS: Neonatal insults from systemic diseases have been implicated in the pathway of impaired neurodevelopment in preterm infants. We aimed to investigate the associations between systemic health factors and retinal nerve fibre layer (RNFL) thic ... Full text Link to item Cite

Norrie Disease

Chapter · January 1, 2023 Norrie disease disease is a rare X-linked recessive disorder characterized by abnormal retinal development and manifesting as congenital blindness or early childhood blindness in male infants. This chapter discusses the clinical features, genetic testing, ... Full text Cite

Imaging in Pediatric Eyes

Chapter · January 1, 2023 Multimodal imaging in pediatric eyes is useful for the diagnosis, treatment, and monitoring of several disease processes. Imaging in pediatric patients can be challenging to perform in clinic and an exam under anesthesia (EUA) may be required. Coordination ... Full text Cite

Intravitreal Delivery of rAAV2tYF-CB-hRS1 Vector for Gene Augmentation Therapy in Patients with X-Linked Retinoschisis: 1-Year Clinical Results.

Journal Article Ophthalmol Retina · December 2022 PURPOSE: To evaluate the safety and efficacy of rAAV2tYF-CB-hRS1, a recombinant adeno-associated virus vector expressing retinoschisin (RS1), in individuals with retinal disease caused by mutations in the RS1 gene. DESIGN: Open-label, phase I/II dose-escal ... Full text Link to item Cite

Insights into the developing fovea revealed by imaging.

Journal Article Prog Retin Eye Res · September 2022 Early development of the fovea has been documented by histological studies over the past few decades. However, structural distortion due to sample processing and the paucity of high-quality post-mortem tissue has limited the effectiveness of this approach. ... Full text Link to item Cite

Association Between Retinal Microanatomy in Preterm Infants and 9-Month Visual Acuity.

Journal Article JAMA Ophthalmol · July 1, 2022 IMPORTANCE: Preterm infants are at risk for poor visual acuity (VA) outcomes, even without retinal problems on ophthalmoscopy. Infant retinal microanatomy may provide insight as to potential causes. OBJECTIVE: To evaluate the association between preterm in ... Full text Link to item Cite

A Unique Case of Syphilitic Hypopyon Panophthalmitis

Journal Article Journal of VitreoRetinal Diseases · July 1, 2022 Purpose: This work reports a unique case of syphilitic hypopyon panophthalmitis. Methods: A case report is presented. Results: A 25-year-old man with a history of HIV and intravenous (IV) drug use presented to an outside hospital with blurred vision and sw ... Full text Cite

INTRAOPERATIVE OPTICAL COHERENCE TOMOGRAPHY AND ENDOSCOPY-GUIDED EXPLANTATION OF ARGUS II DEVICE.

Journal Article Retin Cases Brief Rep · May 1, 2022 PURPOSE: To describe a surgical approach using intraoperative optical coherence tomography and endoscopy for successful Argus II retinal prosthesis system removal. METHODS: Retrospective review of a patient undergoing Argus II explantation 8 months after i ... Full text Link to item Cite

Optical Coherence Tomography Angiography in Pediatric Retinal Disorders

Journal Article Journal of VitreoRetinal Diseases · May 1, 2022 Purpose: The rapid and noninvasive nature of optical coherence tomography angiography (OCTA) makes it a potentially valuable tool for imaging the retina in children. With the optimization of tabletop systems and the development of experimental handheld OCT ... Full text Cite

Automatic Foveal Avascular Zone Segmentation Using Hessian-Based Filter and U-Net Deep Learning Network

Conference IFMBE Proceedings · January 1, 2022 Accurate segmentation of Foveal Avascular Zone (FAZ) in Optical Coherence Tomography Angiography (OCTA) images is important for OCTA images analysis. In this work, we developed an algorithm for automatic segmentation of FAZ in OCTA images using a Hessian-b ... Full text Cite

Repeatability and reproducibility of quantitative OCT angiography measurements from table-top and portable Flex Spectralis devices.

Journal Article Graefes Arch Clin Exp Ophthalmol · January 25, 2024 PURPOSE: The recent development of a portable investigational handheld OCT-angiography (OCTA) device has allowed for expansion of imaging into the operating room (OR) in addition to standard in-clinic imaging. The aim of this study was to assess intravisit ... Full text Link to item Cite

Longitudinal Choroidal Development in Preterm Infants.

Journal Article Ophthalmol Sci · 2024 PURPOSE: To characterize changes in subfoveal choroidal thickness in preterm infants from 30 to 60 weeks' postmenstrual age (PMA). DESIGN: The prospective, observational Study of Eye Imaging in Preterm infantS (BabySTEPS) enrolled infants eligible for reti ... Full text Link to item Cite

Transabdominal Fetal Ultrasound Before Early-Term Planned Delivery for Norrie Disease.

Journal Article J Vitreoretin Dis · 2024 Purpose: To describe a case of early-term planned delivery of a fetus with Norrie disease. Methods: A retrospective chart review was performed. Results: A fetus with an older sibling with bilateral blindness from Norrie disease had positive NPD genetic tes ... Full text Link to item Cite

Chronic Effects of e-Cigarette Aerosol Inhalation on Macular Perfusion Assessed Using OCT Angiography.

Journal Article J Vitreoretin Dis · 2024 Purpose: To determine whether there are significant differences in the microvasculature and central retinal thickness (CRT) between e-cigarette users (user group) and age-matched nonusers (control group) using optical coherence tomography angiography (OCTA ... Full text Link to item Cite

Fluocinolone Acetonide Implant Removal From the Vitreous Cavity

Journal Article Journal of VitreoRetinal Diseases · November 1, 2023 Purpose: To describe a technique for fluocinolone acetonide implant removal from the vitreous cavity. Methods: A case report and review of surgical methods were performed. Results: The technique to remove a fluocinolone acetonide implant from the vitreous ... Full text Cite

PEDIATRIC VITREORETINAL SURGERY TIPS The youngest patients require some extra care in the OR. Here’s what you need to know

Journal Article Retina Today · October 1, 2023 There are significant anatomical differences between pediatric and adult eyes that have important implications for pediatric vitreoretinal surgery. For example, posterior segment volume is less than 50% at birth, and axial length is approximately 70% compa ... Cite

NOVEL METHOD FOR VISUALIZING PERIPHERAL RETINAL STRUCTURES WITH MICROSCOPE-INTEGRATED OPTICAL COHERENCE TOMOGRAPHY.

Journal Article Retin Cases Brief Rep · July 1, 2023 BACKGROUND/PURPOSE: Visualization of peripheral retinal structures with optical coherence tomography (OCT) can be challenging but can offer valuable clinical information. We describe a method for intraoperative OCT of the peripheral retina. METHODS: An inv ... Full text Link to item Cite

Methods for real-time feature-guided image fusion of intrasurgical volumetric optical coherence tomography with digital microscopy.

Journal Article Biomed Opt Express · July 1, 2023 4D-microscope-integrated optical coherence tomography (4D-MIOCT) is an emergent multimodal imaging technology in which live volumetric OCT (4D-OCT) is implemented in tandem with standard stereo color microscopy. 4D-OCT provides ophthalmic surgeons with man ... Full text Link to item Cite

Comparison in Retreatments between Bevacizumab and Ranibizumab Intravitreal Injections for Retinopathy of Prematurity: A Multicenter Study.

Conference Ophthalmology · April 2023 PURPOSE: To compare the types and dosages of anti-vascular endothelial growth factors (VEGFs) to ascertain whether specific dosages or types of injection were associated with retreatment in clinical practice in the United States. DESIGN: Multicenter, retro ... Full text Link to item Cite

Associations between systemic health and retinal nerve fibre layer thickness in preterm infants at 36 weeks postmenstrual age.

Journal Article Br J Ophthalmol · February 2023 BACKGROUND/AIMS: Neonatal insults from systemic diseases have been implicated in the pathway of impaired neurodevelopment in preterm infants. We aimed to investigate the associations between systemic health factors and retinal nerve fibre layer (RNFL) thic ... Full text Link to item Cite

Norrie Disease

Chapter · January 1, 2023 Norrie disease disease is a rare X-linked recessive disorder characterized by abnormal retinal development and manifesting as congenital blindness or early childhood blindness in male infants. This chapter discusses the clinical features, genetic testing, ... Full text Cite

Imaging in Pediatric Eyes

Chapter · January 1, 2023 Multimodal imaging in pediatric eyes is useful for the diagnosis, treatment, and monitoring of several disease processes. Imaging in pediatric patients can be challenging to perform in clinic and an exam under anesthesia (EUA) may be required. Coordination ... Full text Cite

Intravitreal Delivery of rAAV2tYF-CB-hRS1 Vector for Gene Augmentation Therapy in Patients with X-Linked Retinoschisis: 1-Year Clinical Results.

Journal Article Ophthalmol Retina · December 2022 PURPOSE: To evaluate the safety and efficacy of rAAV2tYF-CB-hRS1, a recombinant adeno-associated virus vector expressing retinoschisin (RS1), in individuals with retinal disease caused by mutations in the RS1 gene. DESIGN: Open-label, phase I/II dose-escal ... Full text Link to item Cite

Insights into the developing fovea revealed by imaging.

Journal Article Prog Retin Eye Res · September 2022 Early development of the fovea has been documented by histological studies over the past few decades. However, structural distortion due to sample processing and the paucity of high-quality post-mortem tissue has limited the effectiveness of this approach. ... Full text Link to item Cite

Association Between Retinal Microanatomy in Preterm Infants and 9-Month Visual Acuity.

Journal Article JAMA Ophthalmol · July 1, 2022 IMPORTANCE: Preterm infants are at risk for poor visual acuity (VA) outcomes, even without retinal problems on ophthalmoscopy. Infant retinal microanatomy may provide insight as to potential causes. OBJECTIVE: To evaluate the association between preterm in ... Full text Link to item Cite

A Unique Case of Syphilitic Hypopyon Panophthalmitis

Journal Article Journal of VitreoRetinal Diseases · July 1, 2022 Purpose: This work reports a unique case of syphilitic hypopyon panophthalmitis. Methods: A case report is presented. Results: A 25-year-old man with a history of HIV and intravenous (IV) drug use presented to an outside hospital with blurred vision and sw ... Full text Cite

INTRAOPERATIVE OPTICAL COHERENCE TOMOGRAPHY AND ENDOSCOPY-GUIDED EXPLANTATION OF ARGUS II DEVICE.

Journal Article Retin Cases Brief Rep · May 1, 2022 PURPOSE: To describe a surgical approach using intraoperative optical coherence tomography and endoscopy for successful Argus II retinal prosthesis system removal. METHODS: Retrospective review of a patient undergoing Argus II explantation 8 months after i ... Full text Link to item Cite

Optical Coherence Tomography Angiography in Pediatric Retinal Disorders

Journal Article Journal of VitreoRetinal Diseases · May 1, 2022 Purpose: The rapid and noninvasive nature of optical coherence tomography angiography (OCTA) makes it a potentially valuable tool for imaging the retina in children. With the optimization of tabletop systems and the development of experimental handheld OCT ... Full text Cite

Automatic Foveal Avascular Zone Segmentation Using Hessian-Based Filter and U-Net Deep Learning Network

Conference IFMBE Proceedings · January 1, 2022 Accurate segmentation of Foveal Avascular Zone (FAZ) in Optical Coherence Tomography Angiography (OCTA) images is important for OCTA images analysis. In this work, we developed an algorithm for automatic segmentation of FAZ in OCTA images using a Hessian-b ... Full text Cite

Referable Macular Hemorrhage-A Clinically Meaningful Screening Target in Newborn Infants. Position Statement of the Association of Pediatric Retina Surgeons.

Journal Article Ophthalmic Surg Lasers Imaging Retina · January 2022 Universal newborn eye screening facilitates early diagnosis of ocular abnormalities and mitigates vision loss. "Referral warranted" eye disease is present at birth in about 5.5% of term infants, with "macular hemorrhage impinging on the fovea" representing ... Full text Link to item Cite

Proliferative Vitreoretinopathy

Chapter · January 1, 2022 Proliferative vitreoretinopathy (PVR) is a clinical syndrome associated with proliferation of cells in the vitreous cavity and on the retinal surface leading to tractional forces on the retina. PVR is the most common cause of re-detachment after retinal de ... Full text Cite

Optical Coherence Tomography Angiography Microvascular Variations in Pre- and Posttreatment of Retinoblastoma Tumors.

Journal Article Ocul Oncol Pathol · October 2021 INTRODUCTION: The purpose of this study is to describe variations in microvasculature before and after treatment of treatment-naive lesions and during consolidation therapy of retinoblastoma lesions using an investigational portable optical coherence tomog ... Full text Link to item Cite

Macular OCT Characteristics at 36 Weeks' Postmenstrual Age in Infants Examined for Retinopathy of Prematurity.

Journal Article Ophthalmol Retina · June 2021 PURPOSE: To report our ability to capture,-grade reliably, and analyze bedside macular OCT images from preterm infants and relate OCT findings to biological factors and retinopathy of prematurity (ROP) status at a single time window in the Study of Eye Ima ... Full text Link to item Cite

Microscope-Integrated OCT-Guided Volumetric Measurements of Subretinal Blebs Created by a Suprachoroidal Approach.

Journal Article Transl Vis Sci Technol · June 1, 2021 PURPOSE: To investigate the use of imaging modalities in the volumetric measurement of the subretinal space and examine the volume of subretinal blebs created by a subretinal drug delivery device utilizing microscope-integrated optical coherence tomography ... Full text Link to item Cite

Systemic Factors Associated with a Thinner Choroid in Preterm Infants.

Journal Article Ophthalmol Sci · June 2021 PURPOSE: To identify systemic health factors associated with a thinner choroid, which has been hypothesized as a cause of poor visual outcomes in low-birth weight infants. DESIGN: The prospective, observational Study of Eye Imaging in Preterm Infants (Baby ... Full text Link to item Cite

Preterm Infant Stress During Handheld Optical Coherence Tomography vs Binocular Indirect Ophthalmoscopy Examination for Retinopathy of Prematurity.

Journal Article JAMA Ophthalmol · May 1, 2021 IMPORTANCE: Binocular indirect ophthalmoscopy (BIO) examination for retinopathy of prematurity (ROP) is a well-known cause of repeated preterm infant stress. OBJECTIVE: To compare stress during investigational optical coherence tomography (OCT) imaging to ... Full text Link to item Cite

COMBINED INTERNAL LIMITING MEMBRANE FLAP AND AUTOLOGOUS PLASMA CONCENTRATE TO CLOSE A LARGE TRAUMATIC MACULAR HOLE IN A PEDIATRIC PATIENT.

Journal Article Retin Cases Brief Rep · March 1, 2021 PURPOSE: To describe a case of a large, traumatic macular hole in a pediatric patient closed using an internal limiting membrane flap in combination with autologous plasma concentrate (APC). METHODS: Description of a surgical technique as performed in one ... Full text Link to item Cite

Lightweight Learning-Based Automatic Segmentation of Subretinal Blebs on Microscope-Integrated Optical Coherence Tomography Images.

Journal Article Am J Ophthalmol · January 2021 PURPOSE: Subretinal injections of therapeutics are commonly used to treat ocular diseases. Accurate dosing of therapeutics at target locations is crucial but difficult to achieve using subretinal injections due to leakage, and there is no method available ... Full text Link to item Cite

Initial Presentation of Cutibacterium (Formerly Propionibacterium) acnes Endophthalmitis Twenty-One Years After Cataract Surgery.

Journal Article Ophthalmic Surg Lasers Imaging Retina · January 1, 2021 The authors report a case of an 81-year-old female who presented with sudden onset of light perception vision and intraocular inflammation. After several months of continuing symptoms despite antibiotics, an aqueous tap culture grew Cutibacterium acnes. Th ... Full text Link to item Cite

Pediatric Vitreoretinal Surgery and Integrated Intraoperative Optical Coherence Tomography.

Journal Article Dev Ophthalmol · 2021 Intraoperative portable handheld and microscope-integrated OCT enhance the pediatric vitreoretinal surgeon's diagnostic abilities during examination under anesthesia and surgery, particularly in children who are challenging to examine preoperatively due to ... Full text Link to item Cite

Update on Retinal Drug Toxicities.

Journal Article Curr Ophthalmol Rep · 2021 PURPOSE OF REVIEW: This review aims to provide an update on the clinical presentations and diagnostic findings of drug-induced retinal toxicities. RECENT FINDINGS: Several newly FDA-approved medications have been associated with acute retinal toxicities, i ... Full text Link to item Cite

An Evaluation of the Microvasculature of Macular Nodules in Coats Disease Using Optical Coherence Tomography Angiography: A Report of 3 Cases.

Journal Article J Vitreoretin Dis · 2021 PURPOSE: This work aimed to examine the microvasculature of macular fibrosis in Coats disease. METHODS: Three boys (aged 3, 4, and 6 years) with Coats disease (stages 2B to 3A2) and macular fibrotic nodules were imaged using optical coherence tomography an ... Full text Link to item Cite

Clinicopathologic correlation of aniridia: Optical coherence tomography angiography and histopathologic observations.

Journal Article Am J Ophthalmol Case Rep · December 2020 PURPOSE: To describe optical coherence tomography angiography (OCTA) findings in a patient with aniridia and correlate with representative histopathology. OBSERVATIONS: OCTA images of the macula of a pediatric aniridic patient, who has nystagmus and impair ... Full text Link to item Cite

HANDHELD SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY FINDINGS OF X-LINKED RETINOSCHISIS IN EARLY CHILDHOOD.

Journal Article Retina · October 2020 BACKGROUND/PURPOSE: Using handheld spectral domain optical coherence tomography (SDOCT) imaging to investigate in vivo microanatomic retinal changes and their progression over time in young children with juvenile X-linked retinoschisis (XLRS). METHODS: Thi ... Full text Link to item Cite

Retinal Vasculitis and Intraocular Inflammation after Intravitreal Injection of Brolucizumab.

Journal Article Ophthalmology · October 2020 PURPOSE: To evaluate features and outcomes of eyes with retinal vasculitis and intraocular inflammation (IOI) after intravitreal injection (IVI) of brolucizumab 6 mg/0.05 ml for treatment of neovascular age-related macular degeneration. DESIGN: Retrospecti ... Full text Link to item Cite

Morphological characteristics of early- versus late-onset macular edema in preterm infants.

Journal Article J AAPOS · October 2020 Macular images of infants with early-onset edema (occurring at or before 33 weeks' postmenstrual age [PMA]) and infants with late-onset edema (at or after 36 weeks' PMA) were compared. At first appearance, early-onset edema has a more severe morphology, wi ... Full text Link to item Cite

Optical coherence tomography imaging of the pediatric retina.

Journal Article J AAPOS · October 2020 Optical coherence tomography is an increasingly important part of the retinal specialist's and general ophthalmologist's toolkit for diagnosing and managing retinal disease. This review summarizes the unique considerations and available imaging systems wit ... Full text Link to item Cite

Recent developments in pediatric retina.

Journal Article Curr Opin Ophthalmol · May 2020 PURPOSE OF REVIEW: Pediatric retina is an exciting, but also challenging field, where patient age and cooperation can limit ease of diagnosis of a broad range of congenital and acquired diseases, inherited retinal degenerations are mostly untreatable and s ... Full text Link to item Cite

ADVERSE EVENTS OF THE ARGUS II RETINAL PROSTHESIS: Incidence, Causes, and Best Practices for Managing and Preventing Conjunctival Erosion.

Journal Article Retina · February 2020 PURPOSE: To analyze and provide an overview of the incidence, management, and prevention of conjunctival erosion in Argus II clinical trial subjects and postapproval patients. METHODS: This retrospective analysis followed the results of 274 patients treate ... Full text Link to item Cite

Differentiating Retinal Detachment and Retinoschisis Using Handheld Optical Coherence Tomography in Stage 4 Retinopathy of Prematurity.

Conference JAMA Ophthalmol · January 1, 2020 IMPORTANCE: Progression of retinopathy of prematurity (ROP) to stage 4 may require surgical intervention. The partial retinal detachment of stage 4 ROP may involve the fovea (stage 4B ROP) or may not (stage 4A ROP). This determination has heretofore been b ... Full text Link to item Cite

Appearance of pediatric choroidal neovascular membranes on optical coherence tomography angiography.

Journal Article Graefes Arch Clin Exp Ophthalmol · January 2020 PURPOSE: Compared with fluorescein angiography (FA), the gold standard for diagnosing choroidal neovascularization (CNV) activity, optical coherence tomography angiography (OCTA) is non-invasive without risks associated with fluorescein dye use, and may be ... Full text Link to item Cite

Assessment of Macular Microvasculature in Healthy Eyes of Infants and Children Using OCT Angiography.

Journal Article Ophthalmology · December 2019 PURPOSE: To assess macular vasculature in healthy infants and children using OCT angiography (OCTA). DESIGN: Prospective cross-sectional study. PARTICIPANTS: One hundred thirty-five normal maculae of 89 healthy infants and children (mean age, 8.5±5.3 years ... Full text Open Access Link to item Cite

Microvascular Features of Treated Retinoblastoma Tumors in Children Assessed Using OCTA.

Journal Article Ophthalmic Surg Lasers Imaging Retina · December 1, 2019 BACKGROUND AND OBJECTIVE: To describe the microvascular features of treated, clinically regressed, or reactivated retinoblastoma lesions using an investigational portable optical coherence tomography angiography (OCTA) system. PATIENTS AND METHODS: Single- ... Full text Link to item Cite

Four-Dimensional Microscope-Integrated Optical Coherence Tomography Guidance in a Model Eye Subretinal Surgery.

Conference Retina · October 2019 PURPOSE:: Subretinal delivery of stem cells and gene therapy vectors hold great promise in clinical care. Delivery techniques are evolving. We investigate the utility of 4-dimensional (volumes over time) microscope-integrated optical coherence tomography ( ... Full text Link to item Cite

Longitudinal Study of Visual Function in Dry Age-Related Macular Degeneration at 12 Months.

Journal Article Ophthalmol Retina · August 2019 PURPOSE: To report the 1-year progression of visual impairment on psychophysical tests of visual function in patients with early and intermediate age-related macular degeneration (AMD). DESIGN: Prospective, observational study. PARTICIPANTS: Patients with ... Full text Link to item Cite

Ergonomic handheld OCT angiography probe optimized for pediatric and supine imaging.

Journal Article Biomed Opt Express · May 1, 2019 OCT angiography is a functional extension of OCT that allows for non-invasive imaging of retinal microvasculature. However, most current OCT angiography systems are tabletop systems that are typically used for imaging compliant, seated subjects. These syst ... Full text Link to item Cite

Macular Microvascular Findings in Familial Exudative Vitreoretinopathy on Optical Coherence Tomography Angiography.

Journal Article Ophthalmic Surg Lasers Imaging Retina · May 1, 2019 BACKGROUND AND OBJECTIVE: To describe depth-resolved macular microvasculature abnormalities in patients with familial exudative vitreoretinopathy (FEVR) using optical coherence tomography angiography (OCTA). PATIENTS AND METHODS: Twenty-two eyes (11 eyes o ... Full text Link to item Cite

Analysis of Melanin Structure and Biochemical Composition in Conjunctival Melanocytic Lesions Using Pump-Probe Microscopy.

Journal Article Transl Vis Sci Technol · May 2019 PURPOSE: We analyze melanin structure and biochemical composition in conjunctival melanocytic lesions using pump-probe microscopy to assess the potential for this method to assist in melanoma diagnosis. METHODS: Pump-probe microscopy interrogates transient ... Full text Link to item Cite

Comparison of Optical Coherence Tomography With Fundus Photographs, Fluorescein Angiography, and Histopathologic Analysis in Assessing Coats Disease.

Journal Article JAMA Ophthalmol · February 1, 2019 IMPORTANCE: Coats disease is a rare pediatric vitreoretinopathy that can cause devastating visual and anatomic outcomes. OBJECTIVE: To compare optical coherence tomography (OCT) with fundus photographs, fluorescein angiography (FA), and histopathologic fin ... Full text Link to item Cite

Hyperreflective Vitreous Opacities on Optical Coherence Tomography in a Patient With Bilateral Retinoblastoma.

Journal Article Ophthalmic Surg Lasers Imaging Retina · January 1, 2019 An investigational, portable spectral-domain optical coherence tomography (SD-OCT) unit revealed small hyperreflective opacities in both eyes of a patient with bilateral retinoblastoma. There was no evidence of vitreous seeding on ophthalmoscopy of either ... Full text Link to item Cite

How did you choose the retina subspecialty?

Journal Article Retina Today · January 1, 2019 Cite

Retinal metastatic tumors

Chapter · January 1, 2019 The most common form of intraocular malignancy is metastatic disease. The most common primary sites are the lung in men and the breast in women. Retinal metastases are much rarer than those in the choroid. Biopsy is useful for confirming the diagnosis and ... Full text Cite

Analyzing optical coherence tomography angiography

Chapter · January 1, 2019 Optical coherence tomography angiography (OCTA) provides information regarding blood flow and may aid in monitoring or identifying various pathologies. Analysis of transverse OCTA images of the retinal vasculature is dependent on segmentation of the retina ... Full text Cite

Ocular injury

Chapter · January 1, 2019 Penetrating and nonpenetrating ocular trauma can result in open-globe or closed-globe injuries with a variety of posterior segment pathologies. Open-globe injuries may be associated with vitreous hemorrhage, retinal tears, retinal detachment, or retained i ... Full text Cite

X-linked juvenile retinoschisis

Chapter · January 1, 2019 X-linked retinoschisis (XLRS), an inherited retinal degeneration that affects males, is caused by a mutation in the RS1 gene which encodes the protein complex retinoschisin. This chapter describes the clinical features and optical coherence tomography (OCT ... Full text Cite

Best disease

Chapter · January 1, 2019 Best vitelliform dystrophy is an inherited retinal disease involving the retinal pigment epithelium (RPE), leading to a characteristic bilateral yellow “egg yolk” appearance in the macula. Optical coherence tomography (OCT) is helpful in identifying the vi ... Full text Cite

Commotio retinae, choroidal rupture, and sclopetaria

Chapter · January 1, 2019 Commotio retinae, choroidal rupture, and sclopeteria are possible posterior segment sequelae resulting from blunt trauma to the globe. Each are associated with distinguishing clinical features. Optical coherence tomography (OCT) is helpful to predict visua ... Full text Cite

Other inherited retinal diseases

Chapter · January 1, 2019 Alagille syndrome, choroideremia, and neuronal ceroid lipofuscinosis (Batten disease) are inherited entities with retinal manifestations. This chapter describes the clinical features and optical coherence tomography (OCT) characteristics of other inherited ... Full text Cite

Retinitis pigmentosa

Chapter · January 1, 2019 Full text Cite

Stargardt disease (and fundus flavimaculatus)

Chapter · January 1, 2019 Stargardt disease, or fundus flavimaculatus, is a disease characterized by abnormal accumulation of liposfuscin within the retinal pigment epithelium (RPE). This chapter describes the clinical features and optical coherence tomography (OCT) characteristics ... Full text Cite

Identifying artifacts in OCT angiography

Chapter · January 1, 2019 Artifacts may affect the analysis of optical coherence tomography (OCT) angiography (OCTA) images, leading to incorrect interpretation of data. Table 8.1 lists some common artifacts seen on OCTA images, potential misinterpretations caused by the artifacts, ... Full text Cite

Albinism

Chapter · January 1, 2019 Oculocutaneous albinism and ocular albinism are terms used to describe a group of congenital disorders characterized by variable degrees of depigmentation of the eyes, skin, and hair. This chapter describes the clinical features and optical coherence tomog ... Full text Cite

Retinal detachment and proliferative vitreoretinopathy

Chapter · January 1, 2019 There is a multitude of etiologies for pediatric retinal detachments. These may be tractional, exudative, hemorrhagic, or rhegmatogenous. Rhegmatogenous retinal detachments may be traumatic in etiology or be secondary to a preexisting hereditary vitreoreti ... Full text Cite

Other forms of retinitis pigmentosa-usher syndrome, leber congenital amaurosis, and bardet-biedl syndrome

Chapter · January 1, 2019 There are several other manifestations of retinitis pigmentosa (RP), including Usher syndrome, Leber congenital amaurosis (LCA), and Bardet-Biedl syndrome, among others. This chapter describes the clinical features and optical coherence tomography (OCT) ch ... Full text Cite

Nonaccidental trauma

Chapter · January 1, 2019 Nonaccidental trauma (NAT) or abusive head trauma (AHT), formerly referred to as shaken baby syndrome, occurs in the setting of head trauma in child abuse. The most common examination findings include multilayered retinal hemorrhages that occur in the prer ... Full text Cite

Traumatic macular hole

Chapter · January 1, 2019 Traumatic macular holes may develop following blunt ocular trauma. It has been hypothesized that blunt force is transmitted to the macula through sudden globe compression resulting in foveal “rupture, " or postcontusion changes, with cystoid degeneration a ... Full text Cite

Foveal development

Chapter · January 1, 2019 The fovea is the most important part of human retina that enables fine visual acuity and color vision. Our understanding of foveal development is based primarily on histopathology studies of primates and optical coherence tomography (OCT) has allowed us to ... Full text Cite

Laser pointer injury findings on OCT angiography

Journal Article Digital Journal of Ophthalmology · January 1, 2019 Cite

Orbital arteriovenous fistula presenting with choroidal pulsations on optical coherence tomography

Journal Article American Journal of Ophthalmology Case Reports · December 1, 2018 Purpose: To describe a case of orbital arteriovenous fistula diagnosed based on choroidal pulsations on optical coherence tomography (OCT). Observations: A 69-year-old female originally referred for evaluation of macular degeneration. During acquisition of ... Full text Cite

Handheld Adaptive Optics Scanning Laser Ophthalmoscope.

Journal Article Optica · September 20, 2018 Adaptive optics scanning laser ophthalmoscopy (AOSLO) has enabled in vivo visualization and enhanced understanding of retinal structure and function. Current generation AOSLOs have a large footprint and are mainly limited to imaging cooperative adult subje ... Full text Link to item Cite

VISUALIZATION FROM INTRAOPERATIVE SWEPT-SOURCE MICROSCOPE-INTEGRATED OPTICAL COHERENCE TOMOGRAPHY IN VITRECTOMY FOR COMPLICATIONS OF PROLIFERATIVE DIABETIC RETINOPATHY.

Journal Article Retina · September 2018 PURPOSE: To evaluate the use of live volumetric (4D) intraoperative swept-source microscope-integrated optical coherence tomography in vitrectomy for proliferative diabetic retinopathy complications. METHODS: In this prospective study, we analyzed a subgro ... Full text Link to item Cite

Retinal Anatomy and Electrode Array Position in Retinitis Pigmentosa Patients After Argus II Implantation: An International Study.

Journal Article Am J Ophthalmol · September 2018 PURPOSE: To assess the retinal anatomy and array position in Argus II retinal prosthesis recipients. DESIGN: Prospective, noncomparative cohort study. METHODS: Setting: International multicenter study. PATIENTS: Argus II recipients enrolled in the Post-Mar ... Full text Link to item Cite

Macular Features on Spectral-Domain Optical Coherence Tomography Imaging Associated With Visual Acuity in Coats' Disease.

Journal Article Invest Ophthalmol Vis Sci · June 1, 2018 PURPOSE: To investigate the association between macular features on spectral-domain optical coherence tomography (SD-OCT) and visual acuity (VA) in Coats' disease. METHODS: Thirty-nine eyes (39 patients) with SD-OCT from January 1, 2008 to December 31, 201 ... Full text Link to item Cite

Visual Function Metrics in Early and Intermediate Dry Age-related Macular Degeneration for Use as Clinical Trial Endpoints.

Journal Article Am J Ophthalmol · May 2018 PURPOSE: To evaluate and quantify visual function metrics to be used as endpoints of age-related macular degeneration (AMD) stages and visual acuity (VA) loss in patients with early and intermediate AMD. DESIGN: Cross-sectional analysis of baseline data fr ... Full text Link to item Cite

Fluorescein Angiographic Characteristics of Macular Edema During Infancy.

Journal Article JAMA Ophthalmol · May 1, 2018 IMPORTANCE: Macular edema during infancy, a subclinical feature identified in premature infants by handheld spectral-domain optical coherence tomography (SD-OCT), has been associated with poorer visual acuity and neurodevelopmental outcomes. Features of ma ... Full text Link to item Cite

Volumetric Measurement of Subretinal Blebs Using Microscope-Integrated Optical Coherence Tomography.

Journal Article Transl Vis Sci Technol · April 2018 PURPOSE: We advance studies of subretinal treatments by developing a microscope-integrated optical coherence tomography (MIOCT) image-based method for measuring the volume of therapeutics delivered into the subretinal space. METHODS: A MIOCT image-based vo ... Full text Link to item Cite

Efficacy and Safety of Low-Dose Iodine Plaque Brachytherapy for Juxtapapillary Choroidal Melanoma.

Journal Article Am J Ophthalmol · February 2018 PURPOSE: To evaluate low- vs high-dose plaque brachytherapy for juxtapapillary choroidal melanoma. DESIGN: Retrospective interventional case series. METHODS: Setting: Single institution. STUDY POPULATION: Forty-seven patients with juxtapapillary choroidal ... Full text Link to item Cite

Sheets Glide-Assisted Intraocular Placement of the Argus II Retinal Prosthesis.

Journal Article Ophthalmic Surg Lasers Imaging Retina · February 1, 2018 BACKGROUND AND OBJECTIVE: As an increasing number of vitreoretinal surgeons are implanting retinal prosthesis devices, the need to share surgical techniques to ease implantation in challenging scenarios grows. The authors share a technique to aide in overc ... Full text Link to item Cite

Association of Low Luminance Questionnaire With Objective Functional Measures in Early and Intermediate Age-Related Macular Degeneration.

Journal Article Invest Ophthalmol Vis Sci · January 1, 2018 PURPOSE: To determine whether Low Luminance Questionnaire (LLQ) scores are associated with objective measures of visual function in early and intermediate age-related macular degeneration (AMD). METHODS: Cross-sectional study of subjects with early AMD Age ... Full text Link to item Cite

Argus II retinal prosthesis system: a review of patient selection criteria, surgical considerations, and post-operative outcomes.

Journal Article Clin Ophthalmol · 2018 Retinitis pigmentosa (RP) is a group of heterogeneous inherited retinal degenerative disorders characterized by progressive rod and cone dysfunction and ensuing photoreceptor loss. Many patients suffer from legal blindness by their 40s or 50s. Artificial v ... Full text Link to item Cite

Treatment of Diabetic Retinopathy in Pregnancy

Chapter · January 1, 2018 Management of diabetic retinopathy during pregnancy requires special consideration. It is well known that both diabetic retinopathy severity and macular edema can progress during pregnancy. Fluorescein angiography and intravitreal anti-vascular endothelial ... Full text Cite

Characterization of Long Working Distance Optical Coherence Tomography for Imaging of Pediatric Retinal Pathology.

Journal Article Transl Vis Sci Technol · October 2017 PURPOSE: We determined the feasibility of fovea and optic nerve head imaging with a long working distance (LWD) swept source optical coherence tomography (OCT) prototype in adults, teenagers, and young children. METHODS: A prototype swept source OCT system ... Full text Link to item Cite

Comparison of Visual Outcomes in Coats' Disease: A 20-Year Experience.

Journal Article Ophthalmology · September 2017 PURPOSE: To report differences in visual acuities among patients with Coats' disease who sought treatment at a tertiary care university-based practice. DESIGN: Single-center retrospective cohort study. PARTICIPANTS: Patients with Coats' disease diagnosed c ... Full text Link to item Cite

Microscope-Integrated Optical Coherence Tomography Angiography in the Operating Room in Young Children With Retinal Vascular Disease.

Journal Article JAMA Ophthalmol · May 1, 2017 IMPORTANCE: Intraoperative optical coherence tomography (OCT) has gained traction as an important adjunct for clinical decision making during vitreoretinal surgery, and OCT angiography (OCTA) has provided novel insights in clinical evaluation of retinal di ... Full text Link to item Cite

Correspondence.

Journal Article Retina · May 2017 Full text Link to item Cite

Optical coherence tomography and wide-field fluorescein angiography in retinopathy of prematurity

Chapter · April 6, 2017 The advent and adaptation of many imaging modalities promise to revolutionize our understanding of retinopathy of prematurity (ROP) by improving the detection, diagnosis, and monitoring of response to treatment of this disease. Diagnosis and classification ... Full text Cite

Association of Pediatric Choroidal Neovascular Membranes at the Temporal Edge of Optic Nerve and Retinochoroidal Coloboma.

Journal Article Am J Ophthalmol · February 2017 PURPOSE: To describe the characteristics of pediatric choroidal neovascular membranes (CNVs) associated with retinochoroidal and optic nerve coloboma using optical coherence tomography (OCT) and their response to treatment. DESIGN: Retrospective case serie ... Full text Link to item Cite

Dissociations of the Fluocinolone Acetonide Implant: The Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study.

Journal Article Am J Ophthalmol · April 2016 PURPOSE: To describe fluocinolone acetonide implant dissociations in the Multicenter Uveitis Steroid Treatment (MUST) Trial. DESIGN: Randomized clinical trial with extended follow-up. METHODS: Review of data collected on the first implant in the eye(s) of ... Full text Link to item Cite

A Comparative Study of Rebound Tonometry With Tonopen and Goldmann Applanation Tonometry Following Vitreoretinal Surgery.

Journal Article Am J Ophthalmol · January 2016 PURPOSE: To investigate agreement in intraocular pressure (IOP) measurements among Icare rebound tonometry, Tonopen tonometry, and Goldmann applanation tonometry following vitreoretinal surgery. DESIGN: Reliability analysis of tonometers. METHODS: Fifty-ey ... Full text Link to item Cite

Factors Predicting Visual Acuity Outcome in Intermediate, Posterior, and Panuveitis: The Multicenter Uveitis Steroid Treatment (MUST) Trial.

Journal Article Am J Ophthalmol · December 2015 PURPOSE: To identify factors associated with best-corrected visual acuity (BCVA) presentation and 2-year outcome in 479 intermediate, posterior, and panuveitic eyes. DESIGN: Cohort study using randomized controlled trial data. METHODS: Multicenter Uveitis ... Full text Link to item Cite

Outcome of Treatment of Uveitic Macular Edema: The Multicenter Uveitis Steroid Treatment Trial 2-Year Results.

Journal Article Ophthalmology · November 2015 PURPOSE: To evaluate the 2-year outcomes of uveitic macular edema. DESIGN: Longitudinal follow-up of a randomized cohort. PARTICIPANTS: At baseline, 148 eyes of 117 patients enrolled in the Multicenter Uveitis Steroid Treatment (MUST) Trial had macular ede ... Full text Link to item Cite

FUNCTIONAL OUTCOMES OF YOUNG INFANTS WITH AND WITHOUT MACULAR EDEMA.

Journal Article Retina · October 2015 PURPOSE: The authors relate posterior segment microanatomy from perinatal spectral domain optical coherence tomography to visual acuity, brain abnormalities, and neurodevelopment. METHODS: Thirteen infants (11 preterm and 2 term birth), imaged in the nurse ... Full text Link to item Cite

Brachytherapy in Neovascular AMD

Journal Article Current Ophthalmology Reports · March 1, 2015 Neovascular age-related macular degeneration (AMD) has a complex pathophysiology, and although anti-VEGF therapy has been one of the most significant and successful advances, it is not effective for all patients with neovascular AMD. The potential role of ... Full text Cite

Delay in retinal photoreceptor development in very preterm compared to term infants.

Journal Article Invest Ophthalmol Vis Sci · January 13, 2015 PURPOSE: We compared photoreceptor development from spectral domain optical coherence tomography (SD-OCT) imaging in very preterm infants (VPT, <32 weeks gestational age) with those of term infants. METHODS: The microanatomy of foveal SD-OCT images obtaine ... Full text Link to item Cite

Vitamin D deficiency in neovascular versus nonneovascular age-related macular degeneration.

Journal Article Retina · September 2014 PURPOSE: To compare 25-hydroxyvitamin D (25OHD) levels in patients with neovascular age-related macular degeneration (NVAMD) with patients with nonneovascular age-related macular degeneration and control patients. METHODS: Medical records of all patients d ... Full text Link to item Cite

Retinal metastatic tumors

Chapter · January 1, 2014 Intraocular metastasis is the most common intraocular tumor. The most common primary tumor site is the lung in men and breast in women [1]. In the majority of cases, intraocular metastasis is limited to choroid. Other ocular structures, like the vitreous, ... Full text Cite

Imaging microscopic pigment chemistry in conjunctival melanocytic lesions using pump-probe laser microscopy.

Journal Article Invest Ophthalmol Vis Sci · October 21, 2013 PURPOSE: To report the application of a novel imaging technique, pump-probe microscopy, to analyze patterns of pigment chemistry of conjunctival melanocytic lesion biopsies. METHODS: Histopathologic specimens of eight previously excised conjunctival melano ... Full text Link to item Cite

Histologic development of the human fovea from midgestation to maturity.

Journal Article Am J Ophthalmol · November 2012 PURPOSE: To describe the histologic development of the human central retina from fetal week (Fwk) 22 to 13 years. DESIGN: Retrospective observational case series. METHODS: Retinal layers and neuronal substructures were delineated on foveal sections of fixe ... Full text Link to item Cite

Histologic development of the human fovea from midgestation to maturity.

Journal Article American journal of ophthalmology · November 1, 2012 To describe the histologic development of the human central retina from fetal week (Fwk) 22 to 13 years. Retrospective observational case series. Retinal layers and neuronal substructures were delineated on foveal sections of fixed tissue stained in azure ... Cite

Ultra high-resolution anterior segment optical coherence tomography in the evaluation of anterior corneal dystrophies and degenerations.

Journal Article Ophthalmology · July 2011 PURPOSE: To evaluate the clinical usefulness of a spectral-domain ultra high-resolution anterior segment optical coherence tomography (UHR OCT) in examination, diagnosis, and management of various anterior corneal dystrophies and degenerations. DESIGN: Non ... Full text Link to item Cite

Supraselective intra-arterial chemotherapy: Evaluation of treatment-related complications in advanced retinoblastoma

Journal Article Clinical Ophthalmology · March 25, 2011 Purpose: The purpose of this study is to report the complication profile and safety evaluation of supra selective intra-arterial melphalan chemotherapy in children undergoing treatment with advanced retinoblastoma. Methods: Twelve eyes of 10 children with ... Full text Cite

In vivo morphologic characteristics of Salzmann nodular degeneration with ultra-high-resolution optical coherence tomography.

Journal Article Am J Ophthalmol · February 2011 PURPOSE: To examine the in vivo morphologic properties of Salzmann nodular degeneration with ultra-high-resolution optical coherence tomography (OCT). DESIGN: Interventional case series. SETTING: Single-center academic practice. STUDY POPULATION: Nineteen ... Full text Link to item Cite

Histopathologic examination of failed grafts in descemet's stripping with automated endothelial keratoplasty.

Journal Article Ophthalmology · April 2009 PURPOSE: To study the histopathologic features of 19 corneal posterior lamellar grafts in eyes for which Descemet's stripping with automated endothelial keratoplasty (DSAEK) has failed. DESIGN: Retrospective case series with clinicopathologic correlation. ... Full text Link to item Cite

Blood vessel maturation in human uveal melanoma: spatial distribution of neovessels and mature vasculature.

Journal Article Ophthalmic Res · 2009 PURPOSE: The aims of this study are (1) to evaluate the spatial distribution of neovessels and mature vessels in human uveal melanoma tumors and (2) to determine whether vessel maturation is associated with the major indicators for poor prognosis. METHODS: ... Full text Link to item Cite

LOC387715/HTRA1 and complement factor H variants in patients with age-related macular degeneration seen at the mayo clinic.

Journal Article Ophthalmic Genet · December 2007 PURPOSE: To confirm association of the complement factor H allelic variant (CFH Y402H) and the LOC387715/HTRA1 (LOC387715 A69S) risk alleles with age-related macular degeneration (AMD). STUDY POPULATION: Study of 89 Caucasian patients with neovascular (exu ... Full text Link to item Cite

Cross-species RNAi: Selected Ascaris suum dsRNAs can sterilize Caenorhabditis elegans☆

Journal Article Molecular and Biochemical Parasitology · March 2006 Full text Cite

SUCCESSFUL REPAIR OF RECURRENT OPTIC DISK PIT MACULOPATHY WITH AUTOLOGOUS PLATELET RICH PLASMA: REPORT OF A SURGICAL TECHNIQUE.

Conference Retin Cases Brief Rep PURPOSE: To describe vitreoretinal surgical technique of using autologous platelet-rich plasma to aid in surgical repair of optic pit maculopathy refractive to previous vitrectomy. METHODS: A case of an 18-year-old woman presenting with serous macular deta ... Full text Link to item Cite