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Courtney Rory Goodwin

Associate Professor of Neurosurgery
Neurosurgery
Office hours Tuesday and Thursday 9 am to 5 pm  

Selected Publications


Variation in Oral Board Examination Accommodations Among Specialties.

Journal Article JAMA Netw Open · May 1, 2024 IMPORTANCE: Board certification can have broad implications for candidates' career trajectories, and prior research has found sociodemographic disparities in pass rates. Barriers in the format and administration of the oral board examinations may dispropor ... Full text Link to item Cite

Facets of physical function assessed by patient-reported outcome measures in oncology research.

Journal Article Qual Life Res · April 20, 2024 PURPOSE: The U.S. Food & Drug Administration has identified physical functioning (PF) as a core patient-reported outcome (PRO) in cancer clinical trials. The purpose of this study was to identify PF PRO measures (PROMs) in adult cancer populations and clas ... Full text Link to item Cite

What facets of physical function are most important to adults diagnosed with cancer?

Journal Article Qual Life Res · April 20, 2024 PURPOSE: Successful patient-focused drug development involves selecting and measuring outcomes in clinical trials that are important to patients. The U.S. Food & Drug Administration's definition of clinical benefit includes how patients feel, function, or ... Full text Link to item Cite

Evolution of the Transforaminal Lumbar Interbody Fusion (TLIF): From Open to Percutaneous to Patient-Specific.

Journal Article J Clin Med · April 14, 2024 The transforaminal lumbar interbody fusion (TLIF) has seen significant evolution since its early inception, reflecting advancements in surgical techniques, patient safety, and outcomes. Originally described as an improvement over the posterior lumbar inter ... Full text Open Access Link to item Cite

UDP-6-glucose dehydrogenase in hormonally responsive breast cancers.

Journal Article bioRxiv · March 21, 2024 Survival for metastatic breast cancer is low and thus, continued efforts to treat and prevent metastatic progression are critical. Estrogen is shown to promote aggressive phenotypes in multiple cancer models irrespective of estrogen receptor (ER) status. S ... Full text Link to item Cite

Single-cell RNA sequencing comparison of the human metastatic prostate spine tumor microenvironment.

Journal Article STAR Protoc · March 15, 2024 Spinal column tumors can be difficult to process for single-cell omic studies, given the heterogeneity in tissue. Here, we present a protocol for operating room-to-benchtop single-cell processing of clinical specimens from a prostate cancer patient. We des ... Full text Link to item Cite

Perioperative Blindness in Spine Surgery: A Scoping Literature Review.

Journal Article J Clin Med · February 12, 2024 Perioperative vision loss (POVL) is a devastating surgical complication that impacts both the recovery from surgery and quality of life, most commonly occurring after spine surgery. With rates of spine surgery dramatically increasing, the prevalence of POV ... Full text Open Access Link to item Cite

A blinded study using laser induced endogenous fluorescence spectroscopy to differentiate ex vivo spine tumor, healthy muscle, and healthy bone.

Journal Article Sci Rep · January 22, 2024 Ten patients undergoing surgical resection for spinal tumors were selected. Samples of tumor, muscle, and bone were resected, de-identified by the treating surgeon, and then scanned with the TumorID technology ex vivo. This study investigates whether Tumor ... Full text Open Access Link to item Cite

Prophylactic Muscle Flaps Decrease Wound Complication Rates in Patients with Oncologic Spine Disease.

Journal Article Plast Reconstr Surg · January 1, 2024 BACKGROUND: Patients with oncologic spine disease face a high systemic illness burden and often require surgical intervention to alleviate pain and maintain spine stability. Wound healing complications are the most common reason for reoperation in this pop ... Full text Link to item Cite

Association Between Urbanicity and Outcomes Among Patients with Spinal Cord Ependymomas in the United States.

Journal Article World Neurosurg · January 2024 BACKGROUND: Spinal cord ependymomas (SCEs) represent the most common intramedullary spinal cord tumors among adults. Research shows that access to neurosurgical care and patient outcomes can be greatly influenced by patient location. This study investigate ... Full text Link to item Cite

Treatment of intramedullary spinal cord tumors: a modified Delphi technique of the North American Spine Society Section of Spine Oncology.

Journal Article J Neurosurg Spine · January 1, 2024 OBJECTIVE: Intramedullary spinal cord tumors (IMSCTs) are rare tumors with heterogeneous presentations and natural histories that complicate their management. Standardized guidelines are lacking on when to surgically intervene and the appropriate aggressiv ... Full text Link to item Cite

An adult with recurrent atypical teratoid rhabdoid tumor of the spine.

Journal Article CNS Oncol · January 1, 2024 Atypical teratoid rhabdoid tumors (AT/RT) are rare and highly malignant CNS neoplasms primarily affecting children. Adult cases are extremely uncommon, with only approximately 92 reported. Spinal AT/RT in adults is particularly rare. Here, we present the c ... Full text Link to item Cite

Clinical and Radiographic Outcomes for Patients with Cervical Adjacent Segment Disease Treated with Anterior Cervical Discectomy and Fusion with Integrated Interbody Spacers.

Journal Article World Neurosurg · December 2023 INTRODUCTION: Anterior cervical discectomy and fusion (ACDF) is among the most common spine procedures. Adjacent segment disease (ASD), characterized by degenerative disease at an adjacent spinal level to a prior fusion, is a well-recognized and significan ... Full text Link to item Cite

High Prevalence of Cervical Myelopathy among Hip Fracture Patients

Journal Article Operative Techniques in Orthopaedics · December 1, 2023 Hip fractures are devastating injuries for the elderly and an increasing burden to the healthcare system. Cervical spondylotic myelopathy (CSM), as a common cause of disability, instability, and falls in the elderly population, places patients at risk for ... Full text Cite

Augmented Reality in Spine Surgery Narrative Review: Seeing is Believing

Journal Article Operative Techniques in Orthopaedics · December 1, 2023 In recent years, augmented reality (AR) has emerged as a promising technology in spine surgery. Its benefits are numerous, including enhanced surgical accuracy, improved anatomic approximation, and uninterrupted visualization. It has proven particularly va ... Full text Cite

Sociodemographic Trends in Telemedicine Visit Completion in Spine Patients During the COVID-19 Pandemic.

Journal Article Spine (Phila Pa 1976) · November 1, 2023 STUDY DESIGN: Retrospective cohort study. OBJECTIVE: This study identifies potential disparities in telemedicine utilization in the wake of the COVID-19 pandemic and its aftermath in patients receiving spine surgery. SUMMARY OF BACKGROUND DATA: COVID-19 le ... Full text Link to item Cite

Scoping review on the state of racial disparities literature in the treatment of neurosurgical disease: a call for action.

Journal Article Neurosurg Focus · November 2023 OBJECTIVE: Racial disparities are ubiquitous across medicine in the US. This study aims to assess the evidence of racial disparities within neurosurgery and across its subspecialties, with a specific goal of quantifying the distribution of articles devoted ... Full text Link to item Cite

Promoting diversity in neurosurgery through a virtual symposium.

Journal Article J Neurosurg · October 1, 2023 OBJECTIVE: The rates of women and underrepresented racial and ethnic minority (UREM) students successfully matching into neurosurgical residency are extremely low and do not reflect the makeup of the general population. As of 2019, only 17.5% of neurosurgi ... Full text Link to item Cite

The Association Between Sociodemographic Factors, Social Determinants of Health, and Spine Surgical Patient Portal Utilization.

Journal Article Clin Spine Surg · October 1, 2023 STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To examine patient portal use among the surgical spine patient population across different sociodemographic groups and assess the impact of patient portal use on clinical outcomes. SUMMARY OF BACKGROUND ... Full text Link to item Cite

Associations between urbanicity and spinal cord astrocytoma management and outcomes.

Journal Article Cancer Epidemiol · October 2023 BACKGROUND: The management of spinal cord astrocytomas (SCAs) remains controversial and may include any combination of surgery, radiation, and chemotherapy. Factors such as urbanicity (metropolitan versus non-metropolitan residence) are shown to be associa ... Full text Link to item Cite

Variation in Oral Board Examination Accommodations Among Specialties.

Journal Article JAMA Netw Open · May 1, 2024 IMPORTANCE: Board certification can have broad implications for candidates' career trajectories, and prior research has found sociodemographic disparities in pass rates. Barriers in the format and administration of the oral board examinations may dispropor ... Full text Link to item Cite

Facets of physical function assessed by patient-reported outcome measures in oncology research.

Journal Article Qual Life Res · April 20, 2024 PURPOSE: The U.S. Food & Drug Administration has identified physical functioning (PF) as a core patient-reported outcome (PRO) in cancer clinical trials. The purpose of this study was to identify PF PRO measures (PROMs) in adult cancer populations and clas ... Full text Link to item Cite

What facets of physical function are most important to adults diagnosed with cancer?

Journal Article Qual Life Res · April 20, 2024 PURPOSE: Successful patient-focused drug development involves selecting and measuring outcomes in clinical trials that are important to patients. The U.S. Food & Drug Administration's definition of clinical benefit includes how patients feel, function, or ... Full text Link to item Cite

Evolution of the Transforaminal Lumbar Interbody Fusion (TLIF): From Open to Percutaneous to Patient-Specific.

Journal Article J Clin Med · April 14, 2024 The transforaminal lumbar interbody fusion (TLIF) has seen significant evolution since its early inception, reflecting advancements in surgical techniques, patient safety, and outcomes. Originally described as an improvement over the posterior lumbar inter ... Full text Open Access Link to item Cite

UDP-6-glucose dehydrogenase in hormonally responsive breast cancers.

Journal Article bioRxiv · March 21, 2024 Survival for metastatic breast cancer is low and thus, continued efforts to treat and prevent metastatic progression are critical. Estrogen is shown to promote aggressive phenotypes in multiple cancer models irrespective of estrogen receptor (ER) status. S ... Full text Link to item Cite

Single-cell RNA sequencing comparison of the human metastatic prostate spine tumor microenvironment.

Journal Article STAR Protoc · March 15, 2024 Spinal column tumors can be difficult to process for single-cell omic studies, given the heterogeneity in tissue. Here, we present a protocol for operating room-to-benchtop single-cell processing of clinical specimens from a prostate cancer patient. We des ... Full text Link to item Cite

Perioperative Blindness in Spine Surgery: A Scoping Literature Review.

Journal Article J Clin Med · February 12, 2024 Perioperative vision loss (POVL) is a devastating surgical complication that impacts both the recovery from surgery and quality of life, most commonly occurring after spine surgery. With rates of spine surgery dramatically increasing, the prevalence of POV ... Full text Open Access Link to item Cite

A blinded study using laser induced endogenous fluorescence spectroscopy to differentiate ex vivo spine tumor, healthy muscle, and healthy bone.

Journal Article Sci Rep · January 22, 2024 Ten patients undergoing surgical resection for spinal tumors were selected. Samples of tumor, muscle, and bone were resected, de-identified by the treating surgeon, and then scanned with the TumorID technology ex vivo. This study investigates whether Tumor ... Full text Open Access Link to item Cite

Prophylactic Muscle Flaps Decrease Wound Complication Rates in Patients with Oncologic Spine Disease.

Journal Article Plast Reconstr Surg · January 1, 2024 BACKGROUND: Patients with oncologic spine disease face a high systemic illness burden and often require surgical intervention to alleviate pain and maintain spine stability. Wound healing complications are the most common reason for reoperation in this pop ... Full text Link to item Cite

Association Between Urbanicity and Outcomes Among Patients with Spinal Cord Ependymomas in the United States.

Journal Article World Neurosurg · January 2024 BACKGROUND: Spinal cord ependymomas (SCEs) represent the most common intramedullary spinal cord tumors among adults. Research shows that access to neurosurgical care and patient outcomes can be greatly influenced by patient location. This study investigate ... Full text Link to item Cite

Treatment of intramedullary spinal cord tumors: a modified Delphi technique of the North American Spine Society Section of Spine Oncology.

Journal Article J Neurosurg Spine · January 1, 2024 OBJECTIVE: Intramedullary spinal cord tumors (IMSCTs) are rare tumors with heterogeneous presentations and natural histories that complicate their management. Standardized guidelines are lacking on when to surgically intervene and the appropriate aggressiv ... Full text Link to item Cite

An adult with recurrent atypical teratoid rhabdoid tumor of the spine.

Journal Article CNS Oncol · January 1, 2024 Atypical teratoid rhabdoid tumors (AT/RT) are rare and highly malignant CNS neoplasms primarily affecting children. Adult cases are extremely uncommon, with only approximately 92 reported. Spinal AT/RT in adults is particularly rare. Here, we present the c ... Full text Link to item Cite

Clinical and Radiographic Outcomes for Patients with Cervical Adjacent Segment Disease Treated with Anterior Cervical Discectomy and Fusion with Integrated Interbody Spacers.

Journal Article World Neurosurg · December 2023 INTRODUCTION: Anterior cervical discectomy and fusion (ACDF) is among the most common spine procedures. Adjacent segment disease (ASD), characterized by degenerative disease at an adjacent spinal level to a prior fusion, is a well-recognized and significan ... Full text Link to item Cite

High Prevalence of Cervical Myelopathy among Hip Fracture Patients

Journal Article Operative Techniques in Orthopaedics · December 1, 2023 Hip fractures are devastating injuries for the elderly and an increasing burden to the healthcare system. Cervical spondylotic myelopathy (CSM), as a common cause of disability, instability, and falls in the elderly population, places patients at risk for ... Full text Cite

Augmented Reality in Spine Surgery Narrative Review: Seeing is Believing

Journal Article Operative Techniques in Orthopaedics · December 1, 2023 In recent years, augmented reality (AR) has emerged as a promising technology in spine surgery. Its benefits are numerous, including enhanced surgical accuracy, improved anatomic approximation, and uninterrupted visualization. It has proven particularly va ... Full text Cite

Sociodemographic Trends in Telemedicine Visit Completion in Spine Patients During the COVID-19 Pandemic.

Journal Article Spine (Phila Pa 1976) · November 1, 2023 STUDY DESIGN: Retrospective cohort study. OBJECTIVE: This study identifies potential disparities in telemedicine utilization in the wake of the COVID-19 pandemic and its aftermath in patients receiving spine surgery. SUMMARY OF BACKGROUND DATA: COVID-19 le ... Full text Link to item Cite

Scoping review on the state of racial disparities literature in the treatment of neurosurgical disease: a call for action.

Journal Article Neurosurg Focus · November 2023 OBJECTIVE: Racial disparities are ubiquitous across medicine in the US. This study aims to assess the evidence of racial disparities within neurosurgery and across its subspecialties, with a specific goal of quantifying the distribution of articles devoted ... Full text Link to item Cite

Promoting diversity in neurosurgery through a virtual symposium.

Journal Article J Neurosurg · October 1, 2023 OBJECTIVE: The rates of women and underrepresented racial and ethnic minority (UREM) students successfully matching into neurosurgical residency are extremely low and do not reflect the makeup of the general population. As of 2019, only 17.5% of neurosurgi ... Full text Link to item Cite

The Association Between Sociodemographic Factors, Social Determinants of Health, and Spine Surgical Patient Portal Utilization.

Journal Article Clin Spine Surg · October 1, 2023 STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To examine patient portal use among the surgical spine patient population across different sociodemographic groups and assess the impact of patient portal use on clinical outcomes. SUMMARY OF BACKGROUND ... Full text Link to item Cite

Associations between urbanicity and spinal cord astrocytoma management and outcomes.

Journal Article Cancer Epidemiol · October 2023 BACKGROUND: The management of spinal cord astrocytomas (SCAs) remains controversial and may include any combination of surgery, radiation, and chemotherapy. Factors such as urbanicity (metropolitan versus non-metropolitan residence) are shown to be associa ... Full text Link to item Cite

Measuring Outcomes in Spinal Deformity Surgery.

Journal Article Neurosurg Clin N Am · October 2023 Outcome assessment in adult spinal deformity has evolved from radiographic analysis of curve correction to patient-centered perception of health-related quality-of-life. Oswestry Disability Index and the Scoliosis Research Society-22 Patient Questionnaire ... Full text Open Access Link to item Cite

UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology.

Journal Article Oncotarget · September 28, 2023 UDP-glucose-6-dehydrogenase (UGDH) is a cytosolic, hexameric enzyme that converts UDP-glucose to UDP-glucuronic acid (UDP-GlcUA), a key reaction in hormone and xenobiotic metabolism and in the production of extracellular matrix precursors. In this review, ... Full text Link to item Cite

Hospital Frailty Risk Score and Healthcare Resource Utilization After Surgery for Primary Spinal Intradural/Cord Tumors.

Journal Article Global Spine J · September 2023 OBJECTIVE: The Hospital Frailty Risk Score (HFRS) is a metric that measures frailty among patients in large national datasets using ICD-10 codes. While other metrics have been utilized to demonstrate the association between frailty and poor outcomes in spi ... Full text Link to item Cite

Demographics, Mechanism of Injury, and Outcomes for Acute Upper and Lower Cervical Spinal Cord Injuries: An Analysis of 470 Patients in the Prospective, Multi-Center, North American Clinical Trials Network Registry.

Journal Article J Neurotrauma · September 2023 There is a paucity of data comparing the demographics, mechanism of injury, and outcomes of upper versus lower cervical spinal cord injuries (cSCI). The study objective was to define different clinical manifestations of cSCI. Data were collected prospectiv ... Full text Open Access Link to item Cite

Interhospital Transfer Delays Care for Spinal Cord Injury Patients: A Report from the North American Clinical Trials Network for Spinal Cord Injury.

Journal Article J Neurotrauma · September 2023 Abstract The North America Clinical Trials Network (NACTN) for Spinal Cord Injury (SCI) is a consortium of tertiary medical centers that has maintained a prospective SCI registry since 2004, and it has espoused that early surgical intervention is associate ... Full text Open Access Link to item Cite

Racial Disparities in Perioperative Morbidity Following Oncological Spine Surgery.

Journal Article Global Spine J · June 2023 STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To assess the impact of race on complications following spinal tumor surgery. METHODS: Adults with cancer who underwent spine tumor surgery were identified in the American College of Surgeons National Su ... Full text Link to item Cite

Self-assembled innervated vasculature-on-a-chip to study nociception.

Journal Article Biofabrication · April 13, 2023 Nociceptor sensory neurons play a key role in eliciting pain. An active crosstalk between nociceptor neurons and the vascular system at the molecular and cellular level is required to sense and respond to noxious stimuli. Besides nociception, interaction b ... Full text Link to item Cite

A Comparison of Percutaneous Pedicle Screw Accuracy Between Robotic Navigation and Novel Fluoroscopy-Based Instrument Tracking for Patients Undergoing Instrumented Thoracolumbar Surgery.

Journal Article World Neurosurg · April 2023 BACKGROUND: The accuracy of pedicle screws placed with instrument tracking and robotic navigation are individually comparable or superior to placement using standard fluoroscopy, however head-to-head comparisons between these adjuncts in a similar surgical ... Full text Link to item Cite

Perception of frailty in spinal metastatic disease: international survey of the AO Spine community.

Journal Article J Neurosurg Spine · March 3, 2023 OBJECTIVE: Frailty has not been clearly defined in the context of spinal metastatic disease (SMD). Given this, the objective of this study was to better understand how members of the international AO Spine community conceptualize, define, and assess frailt ... Full text Link to item Cite

High-Impact Chronic Pain Transition in Lumbar Surgery Recipients.

Journal Article Pain Med · March 1, 2023 OBJECTIVE: High-impact chronic pain (HICP) is a term that characterizes the presence of a severe and troubling pain-related condition. To date, the prevalence of HICP in lumbar spine surgery recipients and their HICP transitions from before to after surger ... Full text Open Access Link to item Cite

Racial disparities in inpatient clinical presentation, treatment, and outcomes in brain metastasis.

Journal Article Neurooncol Pract · February 2023 BACKGROUND: Few studies have assessed the impact of race on short-term patient outcomes in the brain metastasis population. The goal of this study is to evaluate the association of race with inpatient clinical presentation, treatment, in-hospital complicat ... Full text Open Access Link to item Cite

How dimensions can guide surgical planning and training: a systematic review of Kambin's triangle.

Journal Article Neurosurg Focus · January 2023 OBJECTIVE: The authors sought to analyze the current literature to determine dimensional trends across the lumbar levels of Kambin's triangle, clarify the role of imaging techniques for preoperative planning, and understand the effect of inclusion of the s ... Full text Link to item Cite

Juxtametallic Bipolar Bone Radiofrequency Ablation: Thermal Monitoring in an Ex-Vivo Model with Specimen MRI and Histopathologic Correlation.

Journal Article J Vasc Interv Radiol · December 2022 PURPOSE: To measure the ablation zone temperature and nontarget tissue temperature during radiofrequency (RF) ablation in bone containing metal instrumentation versus no metal instrumentation (control group). MATERIALS AND METHODS: Ex vivo experiments were ... Full text Link to item Cite

Hospital Frailty Risk Score and healthcare resource utilization after surgery for metastatic spinal column tumors.

Journal Article J Neurosurg Spine · August 1, 2022 OBJECTIVE: The Hospital Frailty Risk Score (HFRS) was developed utilizing ICD-10 diagnostic codes to identify frailty and predict adverse outcomes in large national databases. While other studies have examined frailty in spine oncology, the HFRS has not be ... Full text Link to item Cite

Systemic considerations for the surgical treatment of spinal metastatic disease: a scoping literature review.

Journal Article Lancet Oncol · July 2022 Systemic assessment is a pillar in the neurological, oncological, mechanical, and systemic (NOMS) decision-making framework for the treatment of patients with spinal metastatic disease. Despite this importance, emerging evidence relating systemic considera ... Full text Link to item Cite

Perioperative Pain Management for Elective Spine Surgery: Opioid Use and Multimodal Strategies.

Journal Article World Neurosurg · June 2022 In recent years, physicians and institutions have come to recognize the increasing opioid epidemic in the United States, thus prompting a dramatic shift in opioid prescribing patterns. The lack of well-studied alternative treatment regimens has led to a su ... Full text Open Access Link to item Cite

Attitudes and trends in the use of radiolucent spinal implants: A survey of the North American Spine Society section of spinal oncology

Journal Article North American Spine Society Journal · June 1, 2022 Background: In spinal oncology, titanium implants pose several challenges including artifact on advanced imaging and therapeutic radiation perturbation. To mitigate these effects, there has been increased interest in radiolucent carbon fiber (CF) and CF-re ... Full text Cite

Augmented reality overlay fluoroscopic guidance versus CT-fluoroscopic guidance for sacroplasty.

Journal Article Clin Imaging · May 2022 PURPOSE: To evaluate patient outcomes after sacroplasty (percutaneous sacral augmentation) with guidance using CT compared to fluoroscopy with augmented reality overlay using fluoroscopic cone-beam CT and FDA-approved software (CBCT-AF). MATERIALS AND METH ... Full text Link to item Cite

Treatment Outcomes in Spinal Metastatic Disease With Indeterminate Stability.

Journal Article Global Spine J · April 2022 STUDY DESIGN: Retrospective cohort study. OBJECTIVE: The purpose of this study was to compare outcomes between different treatment modalities for metastatic disease with indeterminate instability (Spinal Instability Neoplastic Score [SINS] 7-12). METHODS: ... Full text Link to item Cite

Muscle Flap Closures in Spine Surgery: Predictors of Usage Patterns and Factors Associated With Postoperative Complications From the NSQIP Database.

Journal Article Clin Spine Surg · February 1, 2022 STUDY DESIGN: Retrospective cohort study using the National Surgical Quality Improvement Program. OBJECTIVE: The objective of this study was to identify preoperative factors that impact the decision to perform prophylactic muscle flap closure and assess ri ... Full text Link to item Cite

Insurance status as a mediator of clinical presentation, type of intervention, and short-term outcomes for patients with metastatic spine disease.

Journal Article Cancer Epidemiol · February 2022 BACKGROUND: It is well established that insurance status is a mediator of disease management, treatment course, and clinical outcomes in cancer patients. Our study assessed differences in clinical presentation, treatment course, mortality rates, and in-hos ... Full text Link to item Cite

Purposeful irradiation of the epidural space to enhance local control without compromising cord sparing in spine radiosurgery†.

Journal Article J Radiosurg SBRT · 2022 PURPOSE: The epidural space is a frequent site of cancer recurrence after spine stereotactic radiosurgery (SSRS). This may be due to microscopic disease in the epidural space which is underdosed to obey strict spinal cord dose constraints. We hypothesized ... Link to item Cite

Beyond Placement of Pedicle Screws - New Applications for Robotics in Spine Surgery: A Multi-Surgeon, Single-Institution Experience.

Journal Article Front Surg · 2022 Interest in robotic-assisted spine surgery has grown as surgeon comfort and technology has evolved to maximize benefits of time saving and precision. However, the Food and Drug Administration (FDA) has currently only approved robotics to assist in determin ... Full text Open Access Link to item Cite

Traumatic Disorders: Surgical Treatment of Myelopathy Secondary to Trauma

Chapter · January 1, 2022 More than 2.1 million Americans sustain accident-related injuries each year. Approximately 10% of these patients die and 11,000–15,000 of them are left with spinal cord injuries. Since the 1990s there has been increased focus on facilitating the neurologic ... Full text Cite

Chondrosarcoma of the spine: a narrative review.

Journal Article Spine J · December 2021 Chondrosarcoma is an uncommon primary bone tumor with an estimated incidence of 0.5 per 100,000 patient-years. Primary chondrosarcoma of the mobile spine and sacrum cumulatively account for less than 20% of all cases, most .commonly causing patients to pre ... Full text Link to item Cite

Comparison of three predictive scoring systems for morbidity in oncological spine surgery.

Journal Article J Clin Neurosci · December 2021 Estimating complications in oncological spine surgery is challenging. The objective of this study was to compare the accuracy of three scoring systems for predicting perioperative morbidity after surgery for spinal metastases. One-hundred and five patients ... Full text Link to item Cite

The role of patient primary language in access to brain tumor resection: Evaluating emergent admission and hospital volume.

Journal Article J Cancer Policy · December 2021 BACKGROUND: This study investigated the effect of limited English proficiency on access to neuro-oncologic surgery. We compared rates of emergent/urgent admission and admission to high-volume hospitals for English and non-English primary language patients ... Full text Link to item Cite

Percutaneous Lumbar Interbody Fusion With an Expandable Titanium Cage Through Kambin's Triangle: A Case Series With Initial Clinical and Radiographic Results.

Journal Article Int J Spine Surg · December 2021 BACKGROUND: There has been an increased interest in lumbar interbody fusions through Kambin's triangle. In this study, we describe percutaneous access to the lumbar disc and insertion of an expandable titanium cage through Kambin's triangle without facetec ... Full text Link to item Cite

Robotic-Assisted Trajectory Into Kambin's Triangle During Percutaneous Transforaminal Lumbar Interbody Fusion-Initial Case Series Investigating Safety and Efficacy.

Journal Article Oper Neurosurg (Hagerstown) · November 15, 2021 BACKGROUND: Minimally invasive spine surgery (MISS) has the potential to further advance with the use of robot-assisted (RA) techniques. While RA pedicle screw placement has been extensively investigated, there is a lack of literature on the use of the rob ... Full text Link to item Cite

Palliative Care Use for Critically Ill Patients With Brain Metastases.

Journal Article J Pain Symptom Manage · November 2021 CONTEXT: Critically ill patients with brain metastases (BM) face significant uncertainty regarding prognosis and survival and can benefit from Palliative care (PC). However, research regarding the role of PC in this population is lacking. OBJECTIVES: We so ... Full text Link to item Cite

Robotic-assisted percutaneous iliac screw fixation for destructive lumbosacral metastatic lesions: an early single-institution experience.

Journal Article Acta Neurochir (Wien) · November 2021 BACKGROUND: Robotic-assisted surgery is becoming more widely applied in surgical subspecialties due to its intraoperative and postoperative advantages such as minimally invasive approach, reduced blood loss, shorter hospital stay, and decreased incidence o ... Full text Link to item Cite

Animal Models of Metastatic Lesions to the Spine: A Focus on Epidural Spinal Cord Compression.

Journal Article World Neurosurg · November 2021 Epidural spinal cord compression (ESCC) secondary to spine metastases is one of the most devastating sequelae of primary cancer as it may lead to muscle weakness, paresthesia, pain, and paralysis. Spine metastases occur through a multistep process that can ... Full text Link to item Cite

Non-English Primary Language Is Associated with Short-Term Outcomes After Supratentorial Tumor Resection.

Journal Article World Neurosurg · November 2021 BACKGROUND: Despite research indicating that patients with non-English primary language (NEPL) have increased hospital length of stay (LOS) for craniotomies, there is a paucity of neurosurgical research examining the impact of language on short-term outcom ... Full text Link to item Cite

A Web-Based Calculator for Predicting the Occurrence of Wound Complications, Wound Infection, and Unplanned Reoperation for Wound Complications in Patients Undergoing Surgery for Spinal Metastases.

Journal Article World Neurosurg · November 2021 BACKGROUND: In the present study, we identified the risk factors for wound complications, wound infection, and reoperation for wound complications after spine metastasis surgery and deployed the resultant model as a web-based calculator. METHODS: Patients ... Full text Link to item Cite

Spinal metastases 2021: a review of the current state of the art and future directions.

Journal Article Spine J · September 2021 Spinal metastases are an increasing societal health burden secondary to improvements in systemic therapy. Estimates indicate that 100,000 or more people have symptomatic spine metastases requiring management. While open surgery and external beam radiothera ... Full text Link to item Cite

Risk factors for prolonged length of stay in patients undergoing surgery for intramedullary spinal cord tumors.

Journal Article J Clin Neurosci · September 2021 UNLABELLED: Primary spine tumors are rare neoplasms that affect about 0.62 per 100,000 individuals in the US. Intramedullary spinal cord tumors (IMSCTs) are the rarest of all primary tumors involving the spine and can cause pain, imbalance, urinary dysfunc ... Full text Link to item Cite

Management of unruptured incidentally found intracranial saccular aneurysms.

Journal Article Neurosurg Rev · August 2021 Unruptured intracranial saccular aneurysms occur in 3-5% of the general population. As the use of diagnostic medical imaging has steadily increased over the past few decades with the increased availability of computed tomography (CT) and magnetic resonance ... Full text Link to item Cite

A Prospective Comparison of the Effects of Instrument Tracking on Time and Radiation During Minimally Invasive Lumbar Interbody Fusion.

Journal Article World Neurosurg · August 2021 BACKGROUND: Minimally invasive surgical techniques have resulted in improved patient outcomes. One drawback has been the increased reliance on fluoroscopy and subsequent exposure to ionizing radiation. We have previously shown the efficacy of a novel instr ... Full text Link to item Cite

Impact of Multidisciplinary Intraoperative Teams on Thirty-Day Complications After Sacral Tumor Resection.

Journal Article World Neurosurg · August 2021 OBJECTIVE: To evaluate the impact of multidisciplinary intraoperative teams on surgical complications in patients undergoing sacral tumor resection. METHODS: We reviewed all patients with primary or metastatic sacral tumors managed at a single comprehensiv ... Full text Link to item Cite

Inpatient palliative care utilization for patients with brain metastases.

Journal Article Neurooncol Pract · August 2021 INTRODUCTION: Given the high symptom burden and complex clinical decision making associated with a diagnosis of brain metastases (BM), specialty palliative care (PC) can meaningfully improve patient quality of life. However, no prior study has formally eva ... Full text Link to item Cite

Plastic surgery wound closure following resection of spinal metastases.

Journal Article Clin Neurol Neurosurg · August 2021 OBJECTIVE: Surgical site infection and dehiscence are devastating complications of surgery for spinal metastases. Wound closure involving plastic surgeons has been proposed as a strategy to lower post-operative complications. Here we investigated whether p ... Full text Link to item Cite

Radiotherapy and Surgical Advances in the Treatment of Metastatic Spine Tumors: A Narrative Review.

Journal Article World Neurosurg · July 2021 Spine tumors encompass a wide range of diseases with a commensurately broad spectrum of available treatments, ranging from radiation for spinal metastases to highly invasive en bloc resection for primary vertebral column malignancies. This high variability ... Full text Link to item Cite

Impact of US hospital center and interhospital transfer on spinal cord injury management: An analysis of the National Trauma Data Bank.

Journal Article J Trauma Acute Care Surg · June 1, 2021 BACKGROUND: Traumatic spinal cord injury (SCI) is a serious public health problem. Outcomes are determined by severity of immediate injury, mitigation of secondary downstream effects, and rehabilitation. This study aimed to understand how the center type a ... Full text Open Access Link to item Cite

Pseudarthrosis rate following anterior cervical discectomy with fusion using an allograft cellular bone matrix: a multi-institutional analysis.

Journal Article Neurosurg Focus · June 2021 OBJECTIVE: The use of osteobiologics, engineered materials designed to promote bone healing by enhancing bone growth, is becoming increasingly common for spinal fusion procedures, but the efficacy of some of these products is unclear. The authors performed ... Full text Open Access Link to item Cite

Characterization and rate of symptomatic adjacent-segment disease after index lateral lumbar interbody fusion: a single-institution, multisurgeon case series with long-term follow-up.

Journal Article J Neurosurg Spine · May 21, 2021 OBJECTIVE: The rate of symptomatic adjacent-segment disease (ASD) after newer minimally invasive techniques, such as lateral lumbar interbody fusion (LLIF), is not known. This study aimed to assess the incidence of surgically significant ASD in adult patie ... Full text Link to item Cite

Interhospital transfer status for spinal metastasis patients in the United States is associated with more severe clinical presentations and higher rates of inpatient complications.

Journal Article Neurosurg Focus · May 2021 OBJECTIVE: In patients with metastatic spinal disease (MSD), interhospital transfer can potentially impact clinical outcomes as the possible benefits of transferring a patient to a higher level of care must be weighed against the negative effects associate ... Full text Open Access Link to item Cite

Systematic review of charged-particle therapy for chordomas and sarcomas of the mobile spine and sacrum.

Journal Article Neurosurg Focus · May 2021 OBJECTIVE: Long-term local control in patients with primary chordoma and sarcoma of the spine and sacrum is increasingly reliant upon en bloc resection with negative margins. At many institutions, adjuvant radiation is recommended; definitive radiation is ... Full text Link to item Cite

"The eye sees only what the mind is prepared to comprehend": Unrecognized incidental findings on intraoperative computed tomography during spine instrumentation surgery.

Journal Article Clin Imaging · April 2021 BACKGROUND: Intraoperative computed tomography (CT) is becoming more widely utilized in spine fusion surgeries. The use of CT-based image guidance has been shown to increase the accuracy in instrumentation placement and to reduce the rate of reoperation. H ... Full text Link to item Cite

Chordoma of the sacrum and mobile spine: a narrative review.

Journal Article Spine J · March 2021 Chordoma is a notochord-derived primary tumor of the skull base and vertebral column known to affect 0.08 to 0.5 per 100,000 persons worldwide. Patients commonly present with mechanical, midline pain with or without radicular features secondary to nerve ro ... Full text Link to item Cite

Prevention of proximal junctional kyphosis or failure: Soft landings and tension band augmentation

Conference Techniques in Orthopaedics · March 1, 2021 As adult spinal deformity surgery becomes more prevalent, the rates of proximal junctional kyphosis (PJK) will rise proportionally. The exact mechanism of PJK is unknown. However, it is thought to be multifactorial and includes violation of the facets and ... Full text Cite

Gender disparities in clinical presentation, treatment, and outcomes in metastatic spine disease.

Journal Article Cancer Epidemiol · February 2021 BACKGROUND: The incidence of metastatic spine disease (MSD) is increasing among cancer patients. Given the poor outcomes and high rates of morbidity associated with MSD, it is important to determine demographic factors that could impact interventions and o ... Full text Link to item Cite

Hematocrit as a predictor of preoperative transfusion-associated complications in spine surgery: A NSQIP study.

Journal Article Clin Neurol Neurosurg · January 2021 BACKGROUND CONTEXT: Preoperative optimization of medical comorbidities prior to spinal surgery is becoming an increasingly important intervention in decreasing postoperative complications and ensuring a satisfactory postoperative course. The treatment of p ... Full text Open Access Link to item Cite

Clinician Experiences in Treatment Decision-Making for Patients with Spinal Metastases: A Qualitative Study.

Journal Article The Journal of bone and joint surgery. American volume · January 2021 BackgroundEffective management of metastatic disease requires multidisciplinary input and entails high risk of disease-related and treatment-related morbidity and mortality. The factors that influence clinician decision-making around spinal metast ... Full text Cite

Biomechanics, evaluation, and management of subaxial cervical spine injuries: A comprehensive review of the literature.

Journal Article J Clin Neurosci · January 2021 STUDY DESIGN: Literature review. OBJECTIVES: It has been reported that 2.4-3.7% of all blunt trauma victims suffer some element of cervical spine fracture, with the majority of these patients suffering from C3-7 (subaxial) involvement. With the improvement ... Full text Open Access Link to item Cite

Objective Test Scores Throughout Orthopedic Surgery Residency Suggest Disparities in Training Experience.

Journal Article J Surg Educ · 2021 Diversifying clinical residencies, particularly in fields that are historically dominated by majority male (M/M) cohorts, is critical to improve both the training experiences of residents and the overall physician workforce. Orthopedic surgery in particula ... Full text Link to item Cite

Management of Acute Traumatic Spinal Cord Injury: A Review of the Literature.

Journal Article Front Surg · 2021 Traumatic spinal cord injury (TSCI) is a debilitating disease that poses significant functional and economic burden on both the individual and societal levels. Prognosis is dependent on the extent of the spinal injury and the severity of neurological dysfu ... Full text Open Access Link to item Cite

A Need for More Molecular Profiling in Brain Metastases.

Journal Article Front Oncol · 2021 As local disease control improves, the public health impact of brain metastases (BrM) continues to grow. Molecular features are frequently different between primary and metastatic tumors as a result of clonal evolution during neoplasm migration, selective ... Full text Link to item Cite

Anterior Spinal Plates: Cervical

Chapter · January 1, 2021 Anterior cervical diskectomy and fusion (ACDF) is one of the most common and effective spine procedures performed, indicated for the treatment of cervical degenerative disk disease. Patients frequently present with neck pain, radiculopathy, or myelopathy s ... Full text Cite

Improved Dysphagia Outcomes in Anchored Spacers Versus Plate-Screw Systems in Anterior Cervical Discectomy and Fusion: A Systematic Review.

Journal Article Global Spine J · December 2020 STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVE: To perform a systematic review of clinical outcomes between stand-alone anchored spacers and traditional cages with plate fixation for dysphagia and pseudoarthrosis using data from clinical tria ... Full text Open Access Link to item Cite

Patient outcomes and tumor control in single-fraction versus hypofractionated stereotactic body radiation therapy for spinal metastases.

Journal Article J Neurosurg Spine · November 6, 2020 OBJECTIVE: Stereotactic body radiation therapy (SBRT) offers efficient, noninvasive treatment of spinal neoplasms. Single-fraction (SF) high-dose SBRT has a relatively narrow therapeutic window, while hypofractionated delivery of SBRT may have an improved ... Full text Link to item Cite

The medicolegal impact of misplaced pedicle and lateral mass screws on spine surgery in the United States.

Journal Article Neurosurg Focus · November 2020 Spine surgery has been disproportionately impacted by medical liability and malpractice litigation, with the majority of claims and payouts related to procedural error. One common area for the potential avoidance of malpractice claims and subsequent payout ... Full text Open Access Link to item Cite

Scoring System to Triage Patients for Spine Surgery in the Setting of Limited Resources: Application to the Coronavirus Disease 2019 (COVID-19) Pandemic and Beyond.

Journal Article World Neurosurg · August 2020 BACKGROUND: As of May 4, 2020, the coronavirus disease 2019 (COVID-19) pandemic has affected >3.5 million people and touched every inhabited continent. Accordingly, it has stressed health systems worldwide, leading to the cancellation of elective surgical ... Full text Link to item Cite

Enhancing Reality: A Systematic Review of Augmented Reality in Neuronavigation and Education.

Journal Article World Neurosurg · July 2020 OBJECTIVE: Augmented reality (AR) is increasingly being explored as an adjunct to conventional neuronavigation systems. AR affords the ability to superimpose 3-dimensional images onto the real environment. A natural extension of this technology is to help ... Full text Link to item Cite

The Role of Radiotherapy for Chordoma Patients Managed With Surgery: Analysis of the National Cancer Database.

Journal Article Spine (Phila Pa 1976) · June 15, 2020 STUDY DESIGN: Retrospective review. OBJECTIVE: To determine if adjuvant radiation therapy (RT) improves overall survival (OS) following surgical resection of chordomas. SUMMARY OF BACKGROUND DATA: The role of RT for the treatment of chordomas remains incom ... Full text Link to item Cite

Awake percutaneous transforaminal lumbar interbody fusion with expandable cage and robotic-assisted navigation and instrumentation: Case report and review of literature

Journal Article Interdisciplinary Neurosurgery: Advanced Techniques and Case Management · June 1, 2020 Awake surgeries are commonly performed in many specialties through the use of local or regional anesthesia. These methods avoid the risks associated with general endotracheal anesthesia and allow faster recovery times. In neurosurgery, awake surgeries are ... Full text Cite

Split cord malformation in adults: Literature review and classification.

Journal Article Clin Neurol Neurosurg · June 2020 The objective of this study was to summarize the available literature describing the presentation, diagnostic evaluation, and management for adults with Type 1 and Type 2 split spinal cord malformations. A review of the literature was performed using the C ... Full text Link to item Cite

Restarting Therapeutic Anticoagulation After Elective Craniotomy for Patients with Chronic Atrial Fibrillation: A Review of the Literature.

Journal Article World Neurosurg · May 2020 The decision to restart systemic anticoagulation after surgery requires a nuanced risk-benefit analysis. The potential for surgical site bleeding must be balanced against the risk of thromboembolic events. In the context of postoperative neurosurgical pati ... Full text Link to item Cite

Preoperative Nutrition Consults Associated with Decreased Postoperative Complication Rate and Decreased Length of Hospital Stay After Spine Metastasis Surgery.

Journal Article World Neurosurg · January 2020 BACKGROUND: Preoperative malnutrition is associated with increased postoperative complication rate and hospital length of stay. However, the degree to which these risks can be mitigated by nutritional consultation has not been well described. To address th ... Full text Link to item Cite

Demographic Factors Associated with Patient-Reported Outcome Measures in Pain Management.

Journal Article Pain Physician · January 2020 BACKGROUND: Pain control is strongly correlated with the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) quality-of-care domains and overall hospital experience. Prior research implicates several factors in the variability of pati ... Link to item Cite

Epidemiology of Spinal Metastatic Disease

Chapter · January 1, 2020 Metastases represent the most prevalent form of spinal neoplasia. The majority of cases occur in the thoracic spine and with a peak incidence in males during the fourth to sixth decade of life. Increased survival times across multiple cancer subtypes have ... Full text Cite

Association of neurologic deficits with surgical outcomes and health-related quality of life after treatment for metastatic epidural spinal cord compression.

Journal Article Cancer · December 1, 2019 BACKGROUND: A critical knowledge gap exists regarding the impact of neurologic deficits on surgical outcomes and health-related quality of life (HRQOL) for patients surgically treated for metastatic epidural spinal cord compression (MESCC). METHODS: This p ... Full text Link to item Cite

Importance of Spinal Alignment in Primary and Metastatic Spine Tumors.

Journal Article World Neurosurg · December 2019 Spinal alignment, particularly with respect to spinopelvic parameters, is highly correlated with morbidity and health-related quality-of-life outcomes. Although the importance of spinal alignment has been emphasized in the deformity literature, spinopelvic ... Full text Open Access Link to item Cite

The Evolving Modern Management of Brain Metastasis.

Journal Article Clin Cancer Res · November 15, 2019 The incidence of brain metastases is increasing as cancer therapies improve and patients live longer, providing new challenges to the multidisciplinary teams that care for these patients. Brain metastatic cancer cells possess unique characteristics that al ... Full text Link to item Cite

Operative and peri-operative considerations in the management of brain metastasis.

Journal Article Cancer Med · November 2019 The number of patients who develop metastatic brain lesions is increasing as the diagnosis and treatment of systemic cancers continues to improve, resulting in longer patient survival. The role of surgery in the management of brain metastasis (BM), particu ... Full text Link to item Cite

The Use of Sacral Osteotomy in the Correction of Spinal Deformity: Technical Report and Systematic Review of the Literature.

Journal Article World Neurosurg · October 2019 BACKGROUND: Flat back deformity is a disabling adverse outcome following instrumented lumbar fusion. As patients are often fused in this non-physiologic alignment, correction is complex and has conventionally required fracture of the preexisting fusion mas ... Full text Link to item Cite

Erratum to intraoperative ketamine may increase risk of post-operative delirium after complex spinal fusion for adult deformity correction.

Journal Article J Spine Surg · September 2019 [This corrects the article DOI: 10.21037/jss.2018.12.10.]. ... Full text Link to item Cite

Prognostic significance of human telomerase reverse transcriptase promoter region mutations C228T and C250T for overall survival in spinal chordomas.

Journal Article Neuro Oncol · August 5, 2019 BACKGROUND: Spinal chordomas, a subtype of primary spinal column malignancies (PSCM), are rare tumors with poor prognosis, and we have limited understanding of the molecular drivers of neoplasia. METHODS: Study design was a retrospective review of prospect ... Full text Link to item Cite

Visceral Fat Volume From Standard Preoperative CT is an Independent Predictor of Short-term Survival in Patients Undergoing Surgery for Metastatic Spine Disease.

Journal Article Clin Spine Surg · July 2019 STUDY DESIGN: This is a retrospective cohort. OBJECTIVE: Determine the relationship of body morphometry to postoperative survival in patients with vertebral metastases. SUMMARY OF BACKGROUND DATA: Most operations for vertebral metastases aim for palliation ... Full text Link to item Cite

Genetic Predisposition to Symptomatic Lumbar Disk Herniation in Pediatric and Young Adult Patients.

Journal Article Spine (Phila Pa 1976) · June 1, 2019 STUDY DESIGN: Case-control whole-genome sequencing analysis of a highly select, young cohort with symptomatic lumbar disk herniation (LDH) compared with the standard variation in a large reference population. OBJECTIVE: To assess genetic influences predisp ... Full text Link to item Cite

Defining Usage and Clinical Outcomes Following Perioperative Fresh Frozen Plasma and Platelet Administration in Spine Surgery Patients.

Journal Article Clin Spine Surg · June 2019 STUDY DESIGN: This was a retrospective study. OBJECTIVES: The main objectives of this study were to characterize the utilization of fresh frozen plasma (FFP) and platelets in spine surgery and the clinical outcomes following their administration. SUMMARY O ... Full text Link to item Cite

Posterior cervical foraminotomy

Chapter · May 7, 2019 Posterior cervical foraminotomy was first described in the mid-twentieth century as a treatment for symptomatic neural foraminal stenosis. This technique is best used in cases of posterior or lateral compression of the nerve root. Because of its high rate ... Full text Cite

Total en bloc resection of primary and metastatic spine tumors.

Journal Article Ann Transl Med · May 2019 Primary and metastatic tumors of the spine represent a significant cause of patient morbidity, and present a management challenge to treating providers. From a neurosurgical standpoint, resection surgery may be warranted in cases of spinal instability, pro ... Full text Link to item Cite

Investigational growth factors utilized in animal models of spinal fusion: Systematic review.

Journal Article World J Orthop · April 18, 2019 BACKGROUND: Over 400000 Americans annually undergo spinal fusion surgeries, yet up to 40% of these procedures result in pseudoarthrosis even with iliac crest autograft, the current "gold standard" treatment. Tissue engineering has the potential to solve th ... Full text Link to item Cite

Local and Distant Recurrence in Resected Sacral Chordomas: A Systematic Review and Pooled Cohort Analysis.

Journal Article Global Spine J · April 2019 STUDY DESIGN: Systematic review. OBJECTIVES: Sacral chordomas are rare, primary tumors of the spine, best treated with en bloc resection. The purpose of this study was to assess the literature for resected sacral chordoma and to quantify the prevalence of, ... Full text Link to item Cite

Independent Associations With 30- and 90-Day Unplanned Readmissions After Elective Lumbar Spine Surgery: A National Trend Analysis of 144 123 Patients.

Journal Article Neurosurgery · March 1, 2019 BACKGROUND: Unplanned hospital readmissions contribute significantly to soaring national healthcare expenditures. To alleviate this burden, Centers for Medicare and Medicaid Services implemented initiatives to penalize hospitals for unplanned 30-d hospital ... Full text Link to item Cite

Intraoperative ketamine may increase risk of post-operative delirium after complex spinal fusion for adult deformity correction.

Journal Article J Spine Surg · March 2019 BACKGROUND: For complex surgery, intraoperative ketamine administration is readily used to reduce post-operative pain. However, there have been a few studies suggesting that intraoperative ketamine may have deleterious effects and impact post-operative del ... Full text Link to item Cite

Neurological Outcomes After Surgical or Conservative Management of Spontaneous Spinal Epidural Abscesses: A Systematic Review and Meta-Analysis of Data From 1980 Through 2016.

Journal Article Clin Spine Surg · February 2019 STUDY DESIGN: This is a meta-analysis. OBJECTIVE: Perform a systematic review and quantitative meta-analysis of neurological outcomes from all available spinal epidural abscess (SEA) literature published between 1980 and 2016. SUMMARY OF BACKGROUND DATA: C ... Full text Link to item Cite

Multidisciplinary surgical planning for en bloc resection of malignant primary cervical spine tumors involving 3D-printed models and neoadjuvant therapies: report of 2 cases.

Journal Article J Neurosurg Spine · January 18, 2019 Effective en bloc resection of primary spinal tumors necessitates careful consideration of adjacent anatomical structures in order to achieve negative margins and reduce surgical morbidity. This can be particularly challenging in the cervical spine, where ... Full text Link to item Cite

Rate of instrumentation changes on postoperative and follow-up radiographs after primary complex spinal fusion (five or more levels) for adult deformity correction.

Journal Article J Neurosurg Spine · January 11, 2019 OBJECTIVEIn the United States, healthcare expenditures have been soaring at a concerning rate. There has been an excessive use of postoperative radiographs after spine surgery and this has been a target for hospitals to reduce unnecessary costs. However, t ... Full text Link to item Cite

Top Ten Tips Palliative Care Clinicians Should Know About Spinal Tumors.

Journal Article J Palliat Med · January 2019 Nearly 20% of cancer patients develop symptomatic spine metastases. Metastatic spine tumors are most commonly extradural tumors that grow quickly and often cause persistent pain, weakness, paresthesias, urinary/bowel dysfunction, and/or paralysis. Surgical ... Full text Link to item Cite

Utility of Cervical Collars Following Cervical Fusion Surgery. Does It Improve Fusion Rates or Outcomes? A Systematic Review.

Journal Article World Neurosurg · December 26, 2018 BACKGROUND: The use of postoperative cervical collars following cervical fusions is common practice. Its use has been purported to improve fusion rates and outcomes. There is a paucity in the strength of evidence to support its clinical benefit. Our object ... Full text Open Access Link to item Cite

Intralesional sacrectomy

Chapter · December 12, 2018 Full text Cite

Analysis of Cervical Spine Injuries in Elderly Patients from 2001 to 2010 Using a Nationwide Database: Increasing Incidence, Overall Mortality, and Inpatient Hospital Charges.

Journal Article World Neurosurg · December 2018 BACKGROUND: Cervical spine (C-spine) injuries cause significant morbidity and mortality among elderly patients. Although the population of older-adults ≥65 years in the United States is expanding, estimates of the burden and outcome of C-spine injury are l ... Full text Link to item Cite

Chiari malformation clusters describe differing presence of concurrent anomalies based on Chiari type.

Journal Article J Clin Neurosci · December 2018 Chiari malformations are structural defects in the posterior fossa where the cerebellum displaces caudally into the foramen magnum and upper spinal canal. These malformations are classified by severity as Types 1-4, each presenting with different associate ... Full text Link to item Cite

Predicting survival for metastatic spine disease: a comparison of nine scoring systems.

Journal Article Spine J · October 2018 BACKGROUND CONTEXT: Despite advances in spinal oncology, research in patient-based prognostic calculators for metastatic spine disease is lacking. Much of the literature in this area investigates the general predictive accuracy of scoring systems in hetero ... Full text Link to item Cite

Contrast-Enhanced CISS Imaging for Evaluation of Neurovascular Compression in Trigeminal Neuralgia: Improved Correlation with Symptoms and Prediction of Surgical Outcomes.

Journal Article AJNR Am J Neuroradiol · September 2018 BACKGROUND AND PURPOSE: Thin-section MR imaging through the posterior fossa is frequently used for trigeminal neuralgia. Typical heavily T2-weighted imaging methods yield high anatomic detail and contrast between CSF and neurovascular structures, but poor ... Full text Link to item Cite

Crizotinib and erlotinib inhibits growth of c-Met+/EGFRvIII+ primary human glioblastoma xenografts.

Journal Article Clin Neurol Neurosurg · August 2018 OBJECTIVES: Receptor tyrosine kinases (RTK), such as c-Met and epidermal growth factor receptor (EGFR), are implicated in the malignant progression of glioblastoma. Studies show that RTK systems can co-modulate distinct and overlapping oncogenic downstream ... Full text Link to item Cite

The Challenges of Renal Cell Carcinoma Metastatic to the Spine: A Systematic Review of Survival and Treatment.

Journal Article Global Spine J · August 2018 STUDY DESIGN: Systematic review. OBJECTIVES: The objective of this systematic review was to answer 2 key questions: (1) What is the clinical presentation and probability of symptomatic improvement following treatment for patients with renal cell carcinoma ... Full text Link to item Cite

Influence of racial disparities on patient-reported satisfaction and short- and long-term perception of health status after elective lumbar spine surgery.

Journal Article J Neurosurg Spine · July 2018 OBJECTIVE In spine surgery, racial disparities have been shown to impact various aspects of surgical care. Previous studies have associated racial disparities with inferior surgical outcomes, including increased complication and 30-day readmission rates af ... Full text Link to item Cite

Transfusion of Red Blood Cells Stored More Than 28 Days is Associated With Increased Morbidity Following Spine Surgery.

Journal Article Spine (Phila Pa 1976) · July 1, 2018 STUDY DESIGN: A retrospective study. OBJECTIVE: The aim of this study was to describe the association between storage duration of packed red blood cells (PRBCs) and perioperative adverse events in patients undergoing spine surgery at a tertiary care center ... Full text Link to item Cite

Epstein-Barr virus-associated smooth muscle tumor involving the spine of an HIV-infected patient: Case report and review of the literature.

Journal Article J Clin Neurosci · June 2018 Within the last two decades, there have been multiple reports of Epstein-Barr virus (EBV)-associated smooth muscle tumors in immunocompromised patients. This includes HIV-infected patients, post-transplant patients, and patients with congenital defects of ... Full text Link to item Cite

Impact of frailty on complications in patients with thoracic and thoracolumbar spinal fracture.

Journal Article Clin Neurol Neurosurg · June 2018 OBJECTIVES: It is well-documented that geriatric patients are at risk for serious injuries after fracture due to pre-existing medical conditions, physical changes of aging, and medication effects. Frailty has been demonstrated to be a predictor of morbidit ... Full text Link to item Cite

Prostate Cancer Disseminated Tumor Cells are Rarely Detected in the Bone Marrow of Patients with Localized Disease Undergoing Radical Prostatectomy across Multiple Rare Cell Detection Platforms.

Journal Article J Urol · June 2018 PURPOSE: Prostate circulating tumor cells escape into peripheral blood and enter bone marrow as disseminated tumor cells, representing an early step before conventionally detectable metastasis. It is unclear how frequently this occurs in localized disease ... Full text Link to item Cite

Risk factors for wound-related reoperations in patients with metastatic spine tumor.

Journal Article J Neurosurg Spine · June 2018 OBJECTIVE Resection of metastatic spine tumors can improve patients' quality of life by addressing pain or neurological compromise. However, resections are often complicated by wound dehiscence, infection, instrumentation failures, and the need for reopera ... Full text Link to item Cite

Targeting UDP-α-D-glucose 6-dehydrogenase inhibits glioblastoma growth and migration.

Journal Article Oncogene · May 2018 UDP-glucose 6-dehydrogenase (UGDH) produces UDP-α-D-glucuronic acid, the precursors for glycosaminoglycans (GAGs) and proteoglycans of the extracellular matrix. Elevated GAG formation has been implicated in a variety of human diseases, including glioblasto ... Full text Link to item Cite

External fixation and surgical fusion for pediatric cervical spine injuries: Short-term outcomes.

Journal Article Clin Neurol Neurosurg · May 2018 OBJECTIVE: To compare in-hospital complication rates in pediatric patients with atlantoaxial and subaxial injuries undergoing either external fixation or surgical fusion. PATIENTS AND METHODS: Baseline and outcome data were obtained from the 2002-2011 Nati ... Full text Link to item Cite

Predictive Factors for Percutaneous Endoscopic Gastrostomy Tube Placement After Anterior Cervical Fusion.

Journal Article Global Spine J · May 2018 STUDY DESIGN: Retrospective case-control study. OBJECTIVES: To identify incidence and risk factors for percutaneous endoscopic gastrostomy (PEG) tube placement after anterior cervical fusion (ACF). METHODS: Adult patients undergoing elective ACF with/witho ... Full text Link to item Cite

Global Identification of Small Ubiquitin-related Modifier (SUMO) Substrates Reveals Crosstalk between SUMOylation and Phosphorylation Promotes Cell Migration.

Journal Article Mol Cell Proteomics · May 2018 Proteomics studies have revealed that SUMOylation is a widely used post-translational modification (PTM) in eukaryotes. However, how SUMO E1/2/3 complexes use different SUMO isoforms and recognize substrates remains largely unknown. Using a human proteome ... Full text Link to item Cite

In-hospital medical complications after non-operative and operative treatment of thoracolumbar fractures in patients over 75 years of age.

Journal Article J Clin Neurosci · April 2018 Management of spine fractures among the elderly is complicated by preexisting comorbidities and increased risk of osseous nonunion. Whether operative treatment is superior for the management of thoracolumbar fractures in the aged is unknown. The purpose of ... Full text Link to item Cite

Management of extranodal lymphoma of the spine: a study of 30 patients.

Journal Article CNS Oncol · April 2018 Extranodal lymphoma of the spine is often a late manifestation of systemic disease, and may result in symptoms of pain, neurologic compromise or spinal instability. Symptomatic relief is generally achieved by radiotherapy alone, but is not sufficient in ad ... Full text Link to item Cite

Percentage change in hemoglobin level and morbidity in spine surgery patients.

Journal Article J Neurosurg Spine · March 2018 OBJECTIVE The aim of this study was to characterize the association between percentage change in hemoglobin (ΔHb)-i.e., the difference between preoperative Hb and in-hospital nadir Hb concentration-and perioperative adverse events among spine surgery patie ... Full text Link to item Cite

Predicting Short-Term Outcome After Surgery for Primary Spinal Tumors Based on Patient Frailty.

Journal Article World Neurosurg · December 2017 OBJECTIVE: Frailty, decreased physiologic reserve and increased vulnerability to stressors beyond what is expected for normal aging, is associated with increased risk of morbidity and mortality. The objective of this study was to develop a preoperative fra ... Full text Link to item Cite

A rare case of metastatic extramammary Paget disease of the spine and review of the literature.

Journal Article J Clin Neurosci · November 2017 Extramammary Paget disease is an intraepithelial neoplasm affecting cells rich in apocrine glands-often located in the vulvar, scrotal, or perianal region. It typically affects older patients, between the ages of 50 and 80years old, and is most often limit ... Full text Link to item Cite

Hardware failure in patients with metastatic cancer to the spine.

Journal Article J Clin Neurosci · November 2017 BACKGROUND: The spine is the most common site of skeletal metastases, affecting approximately 30% of individuals with cancer. The aim of surgical treatment for metastatic spine disease is generally palliative to address pain and/or neurologic compromise, s ... Full text Link to item Cite

Risk factors associated with short-term complications and mortality after pediatric spinal arthrodesis.

Journal Article Neurosurg Focus · October 2017 OBJECTIVE Spinal arthrodesis is routinely performed in the pediatric population. However, there is limited information on the short-term outcomes of pediatric patients who have undergone spine fusion. Thus, the authors conducted a retrospective review of t ... Full text Link to item Cite

Comparison Between S2-Alar-Iliac Screw Fixation and Iliac Screw Fixation in Adult Deformity Surgery: Reoperation Rates and Spinopelvic Parameters

Journal Article Global Spine Journal · October 1, 2017 Study Design: Retrospective cohort study. Objective: The S2-alar-iliac (S2AI) technique has been described as an alternative method for pelvic fixation in place of iliac screws (ISs) in spinal deformity surgery. The objective of this study was to analyze t ... Full text Cite

Effect of liberal blood transfusion on clinical outcomes and cost in spine surgery patients.

Journal Article Spine J · September 2017 BACKGROUND CONTEXT: Blood transfusions in spine surgery are shown to be associated with increased patient morbidity. The association between transfusion performed using a liberal hemoglobin (Hb) trigger-defined as an intraoperative Hb level of ≥10 g/dL, a ... Full text Link to item Cite

Design and testing of a controlled electromagnetic spinal cord impactor for use in large animal models of acute traumatic spinal cord injury.

Journal Article J Clin Neurosci · September 2017 BACKGROUND: Spinal cord injury (SCI) causes debilitating neurological dysfunction and has been observed in warfighters injured in IED blasts. Clinical benefit of SCI treatment remains elusive and better large animal models are needed to assess treatment op ... Full text Link to item Cite

Metastatic human breast cancer to the spine produces mechanical hyperalgesia and gait deficits in rodents.

Journal Article Spine J · September 2017 BACKGROUND CONTEXT: Metastases to the spine are a common source of severe pain in cancer patients. The secondary effects of spinal metastases include pain, bone fractures, hypercalcemia, and neurological deficits. As the disease progresses, pain severity c ... Full text Link to item Cite

The nationwide burden of neurological conditions requiring emergency neurosurgery

Journal Article Neurosurgery · September 1, 2017 Background: Neurosurgical emergencies are an important cause of disability and mortality. Objective: To examine the nationwide burden of neurological conditions requiring emergency neurosurgery. Methods: The Nationwide Inpatient Sample database (2002-2011) ... Full text Cite

Effects of primary and recurrent sacral chordoma on the motor and nociceptive function of hindlimbs in rats: an orthotopic spine model.

Conference J Neurosurg Spine · August 2017 OBJECTIVE Chordoma is a slow-growing, locally aggressive cancer that is minimally responsive to conventional chemotherapy and radiotherapy and has high local recurrence rates after resection. Currently, there are no rodent models of spinal chordoma. In the ... Full text Link to item Cite

Predictors of admission and shunt revision during emergency department visits for shunt-treated adult patients with idiopathic intracranial hypertension.

Journal Article J Neurosurg · August 2017 OBJECTIVE Factors associated with emergency department admission and/or shunt revision for idiopathic intracranial hypertension (IIH) are unclear. In this study, the associations of several factors with emergency department admission and shunt revision for ... Full text Link to item Cite

Abstracts from Hydrocephalus 2016.

Journal Article Fluids Barriers CNS · June 7, 2017 Full text Link to item Cite

Ventriculoatrial versus ventriculoperitoneal shunt complications in idiopathic normal pressure hydrocephalus.

Journal Article Clin Neurol Neurosurg · June 2017 BACKGROUND: Idiopathic normal pressure hydrocephalus (iNPH) is a devastating condition that affects the elderly population. Although ventriculoatrial (VA) shunts can be used to manage iNPH, concerns for associated cardiopulmonary and renal complications ha ... Full text Link to item Cite

Readmissions After Surgical Resection of Metastatic Tumors of the Spine at a Single Institution.

Journal Article World Neurosurg · May 2017 BACKGROUND: Surgical management of spinal metastasis is complex and can be associated with significant postoperative morbidity. Analyzing readmission rates may serve as a proxy for postoperative morbidity and functional decline, allowing patients and physi ... Full text Link to item Cite

Efficacy of primary microvascular decompression versus subsequent microvascular decompression for trigeminal neuralgia.

Journal Article J Neurosurg · May 2017 OBJECTIVE Trigeminal neuralgia (TN) is characterized by intermittent, paroxysmal, and lancinating pain along the distribution of the trigeminal nerve. Microvascular decompression (MVD) directly addresses compression of the trigeminal nerve. The purpose of ... Full text Link to item Cite

Preoperative functional status as a predictor of short-term outcome in adult spinal deformity surgery.

Journal Article J Clin Neurosci · May 2017 Adult spinal deformity (ASD) may cause severe disability and difficulty with daily activities. The purpose of this study was to investigate the impact of preoperative functional status on 30-day major complication occurrence in ASD surgery. A review of the ... Full text Link to item Cite

The epidemiology of spinal tuberculosis in the United States: an analysis of 2002-2011 data.

Journal Article J Neurosurg Spine · April 2017 OBJECTIVE The aim of this study was to investigate the incidence of spinal tuberculosis (TB) in the US between 2002 and 2011. METHODS The Nationwide Inpatient Sample database from 2002 to 2011 was used to identify patients with a discharge diagnosis of TB ... Full text Link to item Cite

Impact of smoking on postoperative complications after anterior cervical discectomy and fusion.

Journal Article J Clin Neurosci · April 2017 The relationship between smoking and the risk of postoperative complications among anterior cervical discectomy and fusion (ACDF) patients remains uncertain. We compared the postoperative complication rates following ACDF surgery among non-smokers, current ... Full text Link to item Cite

Impact of Smoking on 30-day Morbidity and Mortality in Adult Spinal Deformity Surgery.

Journal Article Spine (Phila Pa 1976) · April 1, 2017 STUDY DESIGN: A retrospective cohort study of a prospectively collected surgical database. OBJECTIVE: The aim of this study was to investigate the effect of smoking on 30-day morbidity and mortality in patients undergoing surgery for adult spinal deformity ... Full text Link to item Cite

Review of stereotactic radiosurgery for intradural spine tumors.

Journal Article CNS Oncol · April 2017 Stereotactic radiosurgery (SRS) has become an increasingly popular treatment modality for spinal tumors due to its noninvasive and targeted approach. Whether SRS has the promise of relieving pretreatment symptoms and providing local tumor control for patie ... Full text Link to item Cite

Timing of Complications Occurring Within 30 Days After Adult Spinal Deformity Surgery.

Journal Article Spine Deform · March 2017 STUDY DESIGN: Cross-sectional study of a national surgical database. OBJECTIVE: To investigate the timing of complications after adult spinal deformity (ASD) surgery. SUMMARY OF BACKGROUND DATA: There is limited data on the range of days when complications ... Full text Link to item Cite

The effect of renal dysfunction on short-term outcomes after lumbar fusion.

Journal Article Clin Neurol Neurosurg · February 2017 OBJECTIVE: To compare post-lumbar decompression and fusion complication rates and mortality for patients without preoperative hemodialysis (HD) use with and without renal dysfunction as estimated by glomerular filtration rate (GFR) and creatinine levels. P ... Full text Link to item Cite

Use of S2-Alar-iliac Screws Associated With Less Complications Than Iliac Screws in Adult Lumbosacropelvic Fixation.

Journal Article Spine (Phila Pa 1976) · February 2017 STUDY DESIGN: Retrospective comparative study. OBJECTIVE: To compare clinical and radiographic outcomes between the S2-alar-iliac (S2AI) and the iliac screw (IS) techniques in the adult population and clarify the clinical strength of S2AI screws. SUMMARY O ... Full text Link to item Cite

Congenital thoracolumbar deformity complication

Chapter · January 1, 2017 Incidental durotomy is one of the most common intraoperative complications in spine surgery, including deformity surgery. Unrecognized tears or tears that fail to seal in spite of treatment may result in cerebrospinal fluid (CSF) fistula formation and leak ... Full text Cite

Bone graft options for spinal fusion following resection of spinal column tumors: systematic review and meta-analysis.

Journal Article Neurosurg Focus · January 2017 OBJECTIVE With the advent of new adjunctive therapy, the overall survival of patients harboring spinal column tumors has improved. However, there is limited knowledge regarding the optimal bone graft options following resection of spinal column tumors, due ... Full text Link to item Cite

Patient and operative factors associated with complications following adolescent idiopathic scoliosis surgery: an analysis of 36,335 patients from the Nationwide Inpatient Sample.

Journal Article J Neurosurg Pediatr · December 2016 OBJECTIVE The aim of this study was to investigate the incidence of and factors associated with complications following idiopathic scoliosis surgery in adolescents. METHODS The Nationwide Inpatient Sample database was used to identify patients 10-18 years ... Full text Link to item Cite

Total en bloc spondylectomy for locally aggressive and primary malignant tumors of the lumbar spine.

Journal Article Eur Spine J · December 2016 PURPOSE: To report outcomes after total en bloc spondylectomy (TES) for primary aggressive/malignant tumors of the lumbar spine. METHODS: We performed a retrospective review of 23 neurosurgical patients operated between 2004 and 2014. Outcomes included per ... Full text Link to item Cite

A non-invasive method to produce pressure ulcers of varying severity in a spinal cord-injured rat model.

Journal Article Spinal Cord · December 2016 STUDY DESIGN: Experimental study. OBJECTIVES: The objective of this study was to establish a non-invasive model to produce pressure ulcers of varying severity in animals with spinal cord injury (SCI). SETTING: The study was conducted at the Johns Hopkins H ... Full text Link to item Cite

Development of a Metastatic Spinal Tumor Frailty Index (MSTFI) Using a Nationwide Database and Its Association with Inpatient Morbidity, Mortality, and Length of Stay After Spine Surgery.

Journal Article World Neurosurg · November 2016 OBJECTIVE: The aim of this study was to develop a perioperative metastatic spinal tumor frailty index (MSTFI) that could predict morbidity, mortality, and length of stay. METHODS: A large inpatient hospitalization database was searched from 2002 to 2011 to ... Full text Link to item Cite

Clinical Decision Making: Integrating Advances in the Molecular Understanding of Spine Tumors.

Journal Article Spine (Phila Pa 1976) · October 15, 2016 STUDY DESIGN: Literature review. OBJECTIVE: To describe advancements in molecular techniques, biomarkers, technology, and targeted therapeutics and the potential these modalities hold to predict treatment paradigms, clinical outcomes, and/or survival in pa ... Full text Link to item Cite

Molecular Markers and Targeted Therapeutics in Metastatic Tumors of the Spine: Changing the Treatment Paradigms.

Journal Article Spine (Phila Pa 1976) · October 15, 2016 STUDY TYPE: A review of the literature. OBJECTIVE: The aim of this study was to discuss the evolution of molecular signatures and the history and development of targeted therapeutics in metastatic tumor types affecting the spinal column. SUMMARY OF BACKGRO ... Full text Link to item Cite

Adult cervicothoracic lipomyelomeningocele.

Journal Article J Clin Neurosci · October 2016 Lipomyelomeningocele (LMM) as a cause of tethered cord syndrome (TCS) commonly presents in childhood in the lumbosacral spine. Patients frequently present with cutaneous manifestations, progressive neurological deterioration, bladder dysfunction, and intra ... Full text Link to item Cite

Reliability of a spinal metastasis prognostic score to model 1-year survival.

Journal Article Spine J · September 2016 BACKGROUND: Predicting survival after surgery for patients with metastatic spine disease can be challenging, with multiple variables that can influence a patient's overall survival. Predictive models have been developed to assist clinicians in providing a ... Full text Link to item Cite

S2-Alar-Iliac Screws are Associated with Lower Rate of Symptomatic Screw Prominence than Iliac Screws: Radiographic Analysis of Minimal Distance from Screw Head to Skin.

Journal Article World Neurosurg · September 2016 BACKGROUND: In sacropelvic fixation, the iliac screw technique offers biomechanically strong constructs, but its disadvantages include screw prominence, wound dehiscence, and postoperative pain secondary to the high profile nature. To overcome this drawbac ... Full text Link to item Cite

Timing of surgical treatment for idiopathic normal pressure hydrocephalus: association between treatment delay and reduced short-term benefit.

Journal Article Neurosurg Focus · September 2016 OBJECTIVE A growing body of evidence suggests that longer durations of preoperative symptoms may correlate with worse postoperative outcomes following cerebrospinal fluid (CSF) diversion for treatment of idiopathic normal pressure hydrocephalus (iNPH). The ... Full text Link to item Cite

Clinical outcomes following sublaminar decompression and instrumented fusion for lumbar degenerative spinal pathology.

Journal Article J Clin Neurosci · August 2016 Traditional treatment for lumbar stenosis with instability is laminectomy and posterolateral arthrodesis, with or without interbody fusion. However, laminectomies remove the posterior elements and decrease the available surface area for fusion. Therefore, ... Full text Link to item Cite

A Systematic Review of Clinical Outcomes and Prognostic Factors for Patients Undergoing Surgery for Spinal Metastases Secondary to Breast Cancer

Journal Article Global Spine Journal · August 1, 2016 Study Design Review of the literature. Objective Surgery and cement augmentation procedures are effective palliative treatment of symptomatic spinal metastases. Our objective is to systematically review the literature to describe the survival, prognostic f ... Full text Cite

Clinical, surgical, and molecular prognostic factors for survival after spinal sarcoma resection.

Journal Article Neurosurg Focus · August 2016 OBJECTIVE The goal of this study was to investigate the local recurrence rate and long-term survival after resection of spinal sarcomas. METHODS A retrospective review of patients who underwent resection of primary or metastatic spinal sarcomas between 199 ... Full text Link to item Cite

Factors associated with improved survival following surgery for renal cell carcinoma spinal metastases.

Journal Article Neurosurg Focus · August 2016 OBJECTIVE Renal cell carcinoma (RCC) frequently metastasizes to the spine, causing pain or neurological dysfunction, and is often resistant to standard therapies. Spinal surgery is frequently required, but may result in high morbidity rates. The authors so ... Full text Link to item Cite

Posterior approaches for symptomatic metastatic spinal cord compression.

Journal Article Neurosurg Focus · August 2016 Surgical interventions for spinal metastasis are commonly performed for mechanical stabilization, pain relief, preservation of neurological function, and local tumor reduction. Although multiple surgical approaches can be used for the treatment of metastat ... Full text Link to item Cite

308 High-Resolution Magnetic Resonance Imaging Findings Following Trigeminal Rhizotomy.

Journal Article Neurosurgery · August 2016 INTRODUCTION: Patients with trigeminal neuralgia often undergo glycerol or radiofrequency-thermocoagulation glycerol rhizotomy of the trigeminal nerve for treatment of symptoms. To date, radiological changes in patients with trigeminal neuralgia postrhizot ... Full text Link to item Cite

196 High-Resolution Magnetic Resonance Imaging in Trigeminal Neuralgia: Added Benefit of Contrast Enhanced Constructive Interference in Steady State Imaging.

Journal Article Neurosurgery · August 2016 INTRODUCTION: MRI is performed in the assessment of patients with trigeminal neuralgia (TGN). However, there is poor contrast between vessels and nerves, because both are low in intensity on heavily T2-weighted images. METHODS: A retrospective review was p ... Full text Link to item Cite

194 Efficacy of Primary Microvascular Decompression vs Salvage Microvascular Decompression for Trigeminal Neuralgia.

Journal Article Neurosurgery · August 2016 INTRODUCTION: Trigeminal neuralgia (TN) is a pain disorder characterized by paroxysmal lancinating pain along the distribution of the trigeminal nerve. Mounting clinical evidence supports the neurovascular compression (NVC) theory, suggesting vascular comp ... Full text Link to item Cite

A Systematic Review of Metastatic Hepatocellular Carcinoma to the Spine.

Journal Article World Neurosurg · July 2016 BACKGROUND: Hepatocellular carcinoma (HCC) frequently metastasizes to the spine. The impact of medical and/or surgical intervention on overall survival has been examined in a limited number of clinical studies, and herein we systematically review these dat ... Full text Link to item Cite

En Bloc resection of solitary functional secreting spinal metastasis

Journal Article Global Spine Journal · July 1, 2016 Study Design Literature review. Objective Functional secretory tumors metastatic to the spine can secrete hormones, growth factors, peptides, and/or molecules into the systemic circulation that cause distinct syndromes, clinically symptomatic effects, and/ ... Full text Cite

Comparison of outcomes between patients with idiopathic normal pressure hydrocephalus who received a primary versus a salvage shunt.

Journal Article J Clin Neurosci · July 2016 Placement of a ventriculoperitoneal (VP) shunt is the treatment of choice for communicating hydrocephalus; however, the extent to which VP shunting is able to relieve symptoms in patients who had previously been treated with cerebrospinal fluid diverting t ... Full text Link to item Cite

Predictors of Ventriculoperitoneal Shunt Revision in Patients with Idiopathic Normal Pressure Hydrocephalus.

Journal Article World Neurosurg · June 2016 OBJECTIVE: Few studies have focused on predictive factors of ventriculoperitoneal (VP) shunt revision in patients with idiopathic normal pressure hydrocephalus (iNPH). This study aims to determine whether comorbidities and baseline symptoms are associated ... Full text Link to item Cite

A systematic review of clinical outcomes for patients diagnosed with skin cancer spinal metastases.

Journal Article J Neurosurg Spine · May 2016 OBJECT Surgical procedures and/or adjuvant therapies are effective modalities for the treatment of symptomatic spinal metastases. However, clinical results specific to the skin cancer spinal metastasis cohort are generally lacking. The purpose of this stud ... Full text Link to item Cite

Extraneural Glioblastoma Multiforme Vertebral Metastasis.

Journal Article World Neurosurg · May 2016 Glioblastoma multiforme (GBM) is the most common malignant central nervous system tumor; however, extraneural metastasis is uncommon. Of those that metastasize extraneurally, metastases to the vertebral bodies represent a significant proportion. We present ... Full text Link to item Cite

Non-hepatocellular carcinoma spinal metastases.

Journal Article J Clin Neurosci · May 2016 Metastases to the spine from non-hepatocellular carcinomas, such as cholangiocarcinoma and angiosarcoma, occur rarely. With improvements in oncologic care, the number of patients diagnosed with metastatic cancer is expected to increase. We performed a syst ... Full text Link to item Cite

Consensus building in metastatic spine disease.

Journal Article Spine J · May 2016 Arana E, Kovacs FM, Royuela A, Asenjo B, Pérez-Ramírez Ú, Zamora J, the Spanish Back Pain Research Network Task Force for the Improvement of Inter-Disciplinary Management of Spinal Metastasis. Spine Instability Neoplastic Score: agreement across different ... Full text Link to item Cite

Tumor microenvironment tenascin-C promotes glioblastoma invasion and negatively regulates tumor proliferation.

Journal Article Neuro Oncol · April 2016 BACKGROUND: Glioblastoma (GBM) is the most frequent and aggressive primary brain tumor in adults. Recent research on cancer stroma indicates that the brain microenvironment plays a substantial role in tumor malignancy and treatment responses to current ant ... Full text Link to item Cite

Microarray-Based Phospho-Proteomic Profiling of Complex Biological Systems.

Journal Article Transl Oncol · April 2016 Protein microarray technology has been successfully used for identifying substrates of purified activated kinases. We used protein microarrays to globally interrogate the effects of PTEN and Akt activity on the phospho-kinome of in vitro and in vivo glioma ... Full text Open Access Link to item Cite

Mobile spine chordoma: results of 166 patients from the AOSpine Knowledge Forum Tumor database.

Journal Article J Neurosurg Spine · April 2016 OBJECT: A chordoma is an indolent primary spinal tumor that has devastating effects on the patient's life. These lesions are chemoresistant, resistant to conventional radiotherapy, and moderately sensitive to proton therapy; however, en bloc resection rema ... Full text Link to item Cite

Pneumocephalus leading to the diagnosis of cerebrospinal fluid leak and esophageal perforation after cervical spine surgery.

Journal Article J Clin Neurosci · April 2016 Pneumocephalus is a collection of air within in the intracranial cavity, most commonly seen following traumatic injury or cranial surgeries. Esophageal injury and cerebrospinal fluid (CSF) leak are rare complications that may occur following anterior cervi ... Full text Link to item Cite

Epidural spinal compression as an initial presentation of Hodgkin lymphoma.

Journal Article J Clin Neurosci · April 2016 Classical Hodgkin lymphoma (CHL) commonly arises in lymph nodes and initial presentation with extranodal disease is rare. We report a patient who presented with progressively worsening back pain, lower extremity weakness and numbness concerning for a myelo ... Full text Link to item Cite

Clinical outcomes after ventriculoatrial shunting for idiopathic normal pressure hydrocephalus.

Journal Article Clin Neurol Neurosurg · April 2016 INTRODUCTION: Idiopathic normal pressure hydrocephalus (iNPH) is a neurological disorder that classically presents with a triad of progressive gait impairment, urinary incontinence, and cognitive deterioration. Treatment predominantly involves ventriculope ... Full text Link to item Cite

Local delivery methods of therapeutic agents in the treatment of diffuse intrinsic brainstem gliomas.

Journal Article Clin Neurol Neurosurg · March 2016 Brainstem gliomas comprise 10-20% of all pediatric central nervous system (CNS) tumors and diffuse intrinsic pontine gliomas (DIPGs) account for the majority of these lesions. DIPG is a rapidly progressive disease with almost universally fatal outcomes and ... Full text Link to item Cite

Primary lesion location influences postoperative survival in patients with metastatic colorectal spinal lesions.

Journal Article J Clin Neurosci · March 2016 Spinal metastasis from colorectal cancer occurs rarely. However, with increasing incidence of colorectal cancer in the setting of improved therapies, physicians are more likely to encounter such patients. We performed a retrospective review of patients who ... Full text Link to item Cite

Cervical Fusion for Absent Pedicle Syndrome Manifesting with Myelopathy.

Journal Article World Neurosurg · February 2016 BACKGROUND: Absent congenital pedicle syndrome is a posterior arch defect characterized by numerous congenital and mechanical abnormalities that result from disconnection of the anterior and posterior columns of the spinal canal. Absent congenital pedicle ... Full text Link to item Cite

Successful anterior fusion following posterior cervical fusion for revision of anterior cervical discectomy and fusion pseudarthrosis.

Journal Article J Clin Neurosci · February 2016 Pseudarthrosis occurs after approximately 2-20% of anterior cervical discectomy and fusion (ACDF) procedures; it is unclear if posterior or anterior revision should be pursued. In this study, we retrospectively evaluate the outcomes in 22 patients with pse ... Full text Link to item Cite

Epithelial-myoepithelial carcinoma metastasis to the thoracic spine.

Journal Article J Clin Neurosci · February 2016 Epithelial-myoepithelial carcinoma (EMC) is a very rare salivary gland malignancy accounting for less than 1% of salivary gland tumors, and classically arises from the parotid gland in females. Spinal cord compression caused by EMC metastasized from the pa ... Full text Link to item Cite

More on Scylla and Charybdis.

Journal Article Eur J Intern Med · January 2016 Full text Link to item Cite

A systematic review of the use of expandable cages in the cervical spine.

Journal Article Neurosurg Rev · January 2016 Expandable vertebral body replacement cages (VBRs) have been widely used for reconstruction of the thoracolumbar spine following corpectomy. However, their use in the cervical spine is less common, and currently, no expandable cages on the market are clear ... Full text Link to item Cite

Surgical Management of Osteoblastoma of the Spine: Case Series and Review of the Literature.

Journal Article Turk Neurosurg · 2016 AIM: To describe the demographics, clinical and radiologic presentation, surgical considerations, and clinical outcomes associated with spinal osteoblastoma. MATERIAL AND METHODS: A spinal tumor database of 522 patients treated surgically at a single insti ... Full text Link to item Cite

Postoperative survival and functional outcomes for patients with metastatic gynecological cancer to the spine: case series and review of the literature.

Journal Article J Neurosurg Spine · January 2016 OBJECTIVE: Spinal metastases from gynecological cancers are rare, with few cases reported in the literature. In this study, the authors examine a series of patients with spinal metastases from gynecological cancer and review the literature. METHODS: The ca ... Full text Link to item Cite

The pathophysiology of intervertebral disc disease

Chapter · January 1, 2016 The degeneration of the intervertebral disc results from several multifactorial pathophysiologic processes. Here, we discuss the anatomy of the intervertebral disc along with a presentation of several pathologic processes including vascular insufficiency ( ... Cite

The Use of an Aspirating/Resecting Device to Reduce Stoma Closure Following Endoscopic Third Ventriculostomy for Aqueductal Stenosis.

Journal Article Oper Neurosurg (Hagerstown) · December 1, 2015 BACKGROUND: Endoscopic third ventriculostomy (ETV) is commonly used to treat obstructive hydrocephalus. Closure of the stoma can be associated with symptom recurrence and need for further surgical intervention. OBJECTIVE: To describe the use of a side-cutt ... Full text Link to item Cite

Reduced CSF leak in complete calvarial reconstructions of microvascular decompression craniectomies using calcium phosphate cement.

Journal Article J Neurosurg · December 2015 OBJECT: Calcium phosphate cement provides a biomaterial that can be used for calvarial reconstruction in a retrosigmoid craniectomy for microvascular decompression (MVD). This study evaluates the outcomes of postoperative CSF leak and wound infection for p ... Full text Link to item Cite

The Utility of Computed Tomography in Shunted Patients with Idiopathic Intracranial Hypertension Presenting to the Emergency Department.

Journal Article World Neurosurg · December 2015 BACKGROUND: Shunted patients with idiopathic intracranial hypertension (IIH) often present to the emergency department (ED) for symptoms related to their disease. Although brain imaging with computed tomography (CT) is often performed, particularly in the ... Full text Link to item Cite

Thoracic pneumorachis.

Journal Article Spine J · December 1, 2015 Full text Link to item Cite

A massive pelvic mucocele presenting as a cystic sacral mass.

Journal Article J Clin Neurosci · November 2015 We present a man, with a complex medical and surgical history, who had a large pelvic non-appendiceal cystadenoma, presenting as a cystic sacral mass causing obstructive urinary symptoms and renal failure. Mucocele should be included in the differential di ... Full text Link to item Cite

A Comprehensive Review of Complication Rates After Surgery for Adult Deformity: A Reference for Informed Consent.

Journal Article Spine Deform · November 2015 OBJECTIVE: An up-to-date review of recent literatures and a comprehensive reference for informed consent specific to ASD complications is lacking. The goal of the present study was to determine current complication rates after ASD surgery, in order to prov ... Full text Open Access Link to item Cite

Are shunt series and shunt patency studies useful in patients with shunted idiopathic intracranial hypertension in the emergency department?

Journal Article Clin Neurol Neurosurg · November 2015 OBJECTIVES: Shunt series and shunt patency studies can be performed in the emergency department (ED) to evaluate for shunt malfunction in patients with idiopathic intracranial hypertension (IIH). Here, we examine the utility of these studies in this specif ... Full text Link to item Cite

Mobile Spine Chordoma: Results of 166 Patients

Journal Article The Spine Journal · October 2015 Full text Cite

Tokuhashi score is predictive of survival in a cohort of patients undergoing surgery for renal cell carcinoma spinal metastases.

Journal Article Eur Spine J · October 2015 PURPOSE: Renal cell carcinoma (RCC) is an aggressive disease that metastasizes to the spine often requiring surgery. However, selecting the appropriate surgical intervention can be challenging. The Tokuhashi scoring system can be used to predict survival a ... Full text Link to item Cite

Epidural spinal involvement of Erdheim-Chester disease causing myelopathy.

Journal Article J Clin Neurosci · September 2015 We present a 25-year-old woman with Erdheim-Chester disease (ECD) presenting with progressive myelopathy from multiple compressive spinal epidural lesions who required cervicothoracic decompression and fusion, and summarize the literature on epidural spina ... Full text Link to item Cite

A Screen for Extracellular Signal-Regulated Kinase-Primed Glycogen Synthase Kinase 3 Substrates Identifies the p53 Inhibitor iASPP.

Journal Article J Virol · September 2015 UNLABELLED: The Kaposi's sarcoma-associated herpesvirus (KSHV) LANA protein is essential for the replication and maintenance of virus genomes in latently KSHV-infected cells. LANA also drives dysregulated cell growth through a multiplicity of mechanisms th ... Full text Link to item Cite

Bilateral pulmonary emboli associated with intraoperative use of thrombin-based hemostatic matrix following lumbar spine interbody fusion.

Journal Article J Clin Neurosci · September 2015 Here we describe a patient with bilateral pulmonary emboli (PE) associated with thrombin-based hemostatic matrix (TBHM) use in the setting of a possible venous injury during transforaminal lumbar interbody fusion in the treatment of degenerative spondyloli ... Full text Link to item Cite

Lumboatrial shunt in a patient with Crouzon syndrome complicated by pseudotumor cerebri.

Journal Article J Clin Neurosci · September 2015 A 25-year-old man with Crouzon syndrome complicated by pseudotumor cerebri and multiple shunt failures presented with progressive back and neck pain, intermittent headaches, and associated vomiting secondary to shunt infection. Due to his previous history ... Full text Link to item Cite

Functional gait outcomes for idiopathic normal pressure hydrocephalus after primary endoscopic third ventriculostomy.

Journal Article J Clin Neurosci · August 2015 We evaluated if patients with idiopathic normal pressure hydrocephalus (iNPH) showed functional improvement after primary endoscopic third ventriculostomy (ETV). The efficacy of ETV for iNPH remains controversial. We retrospectively reviewed 10 consecutive ... Full text Link to item Cite

Outcomes and Experience with Lumbopleural Shunts in the Management of Idiopathic Intracranial Hypertension.

Journal Article World Neurosurg · August 2015 OBJECTIVE: To report five patients who underwent lumbopleural (LPl) shunting for the treatment of idiopathic intracranial hypertension (IIH) and to describe the considerations, complications, and outcomes related to this rarely described procedure. METHODS ... Full text Link to item Cite

Merkel Cell Spinal Metastasis: Management in the Setting of a Poor Prognosis

Journal Article Global Spine Journal · August 1, 2015 Study Design Case report. Objective Merkel cell carcinoma is an aggressive neuroendocrine carcinoma with a poor prognosis. Metastatic epidural spinal cord compression (MESCC) is a debilitating disease causing neurologic deficits. The surgical management fo ... Full text Cite

Immunotherapy: Present and future directions

Chapter · July 1, 2015 The role of immunotherapy in oncology has rapidly expanded over the past century. The old paradigm posited the brain to be an "immune-privileged" location, as the tumor microenvironment has been shown to be highly immunosuppressive in nature. However, more ... Cite

The biomechanics of pedicle screw augmentation with cement.

Journal Article Spine J · June 1, 2015 BACKGROUND CONTEXT: A persistent challenge in spine surgery is improving screw fixation in patients with poor bone quality. Augmenting pedicle screw fixation with cement appears to be a promising approach. PURPOSE: The purpose of this study was to survey t ... Full text Link to item Cite

Does CT wand guidance improve shunt placement in patients with hydrocephalus?

Journal Article Clin Neurol Neurosurg · May 2015 OBJECT: To evaluate the effectiveness of stereotactic navigation in enhancing the accuracy of ventricular shunt placement in patients with hydrocephalus. METHODS: A retrospective cohort study at a single institution by a single surgeon was performed. Conse ... Full text Link to item Cite

A systematic assessment of the use of platelet-rich plasma in spinal fusion.

Journal Article Ann Biomed Eng · May 2015 Spinal fusion is one of the most commonly performed procedures for the treatment of spinal instability caused by a multitude of pathologies. However, despite significant advances in spinal instrumentation, failed fusion, or pseudoarthrosis, remains a signi ... Full text Link to item Cite

Outcomes following Surgical Intervention for Impending and Gross Instability (SINS criteria) Caused by Multiple Myeloma in the Spinal Column

Journal Article Global Spine Journal · May 2015 Introduction Multiple myeloma is the most common primary tumor of the spine. Spinal multiple myeloma is classically a radiosensitive lesion; however, clinical or radiographic signs of instability merit surgical in ... Full text Cite

Automatic localization of target vertebrae in spine surgery: clinical evaluation of the LevelCheck registration algorithm.

Journal Article Spine (Phila Pa 1976) · April 15, 2015 STUDY DESIGN: A 3-dimensional-2-dimensional (3D-2D) image registration algorithm, "LevelCheck," was used to automatically label vertebrae in intraoperative mobile radiographs obtained during spine surgery. Accuracy, computation time, and potential failure ... Full text Link to item Cite

Venous sinus stenting is a valuable treatment for fulminant idiopathic intracranial hypertension.

Journal Article J Clin Neurosci · April 2015 Over the past 10 years, transverse sinus stenting has grown in popularity as a treatment for idiopathic intracranial hypertension. Although promising results have been demonstrated in several reported series, the vast majority of patients in these series h ... Full text Link to item Cite

Surgical Outcomes in Patients with High Spinal Instability Neoplasm Score Secondary to Spinal Giant Cell Tumors

Journal Article Global Spine Journal · March 26, 2015 Study Design Retrospective review. Objective To describe the surgical outcomes in patients with high preoperative Spinal Instability Neoplastic Score (SINS) secondary to spinal giant cell tumors (GCT) and evaluate the impact of en bloc versus intralesional ... Full text Cite

Outcomes following surgical intervention for impending and gross instability caused by multiple myeloma in the spinal column.

Journal Article J Neurosurg Spine · March 2015 OBJECT: Multiple myeloma is the most common primary tumor of the spine and is the most common primary malignant tumor of bone. Although spinal myeloma is classically a radiosensitive lesion, clinical or radiographic signs of instability merit surgical inte ... Full text Link to item Cite

Factors Associated with Life Expectancy in Patients with Metastatic Spine Disease from Adenocarcinoma of the Lung

Journal Article Global Spine Journal · January 7, 2015 Study Design Retrospective study. Objective Our objective was to identify preoperative prognostic factors associated with survival in patients with spinal metastasis from lung carcinoma. Methods A retrospective analysis of 26 patients diagnosed with lung c ... Full text Cite

Epidemiologic, functional, and oncologic outcome analysis of spinal sarcomas treated surgically at a single institution over 10 years.

Journal Article Spine J · January 1, 2015 BACKGROUND CONTEXT: Spinal sarcomas are aggressive tumors that originate from the cells of mesechymal origin, specifically fat, cartilage, bone, and muscle. They are high-grade lesions, and treatment of spinal sarcomas can involve chemotherapy, radiation t ... Full text Link to item Cite

Metastatic extrapulmonary small cell carcinoma to the cerebellopontine angle: a case report and review of the literature.

Journal Article Case Rep Oncol Med · 2015 Extrapulmonary small cell carcinomas (EPSCC) are rare malignancies with poor patient prognoses. We present the case of a 63-year-old male who underwent surgical resection of a poorly differentiated small cell carcinoma, likely from a small intestinal prima ... Full text Open Access Link to item Cite

Risk factors for failed transverse sinus stenting in pseudotumor cerebri patients.

Journal Article Clin Neurol Neurosurg · December 2014 BACKGROUND: Idiopathic intracranial hypertension (IIH) when no underlying etiology is found, is a clinical syndrome characterized by elevated intracranial pressure (ICP) (>25 cm H2O), which may lead to headaches and visual symptoms. In patients with IIH wh ... Full text Link to item Cite

Evaluation of complication rates of pediatric cranial procedures in which a polyethylene glycol sealant was used.

Journal Article J Neurosurg Pediatr · November 2014 OBJECT: Polyethylene glycol (PEG) sealant in conjunction with standard closure techniques is effective in preventing CSF leaks after cranial procedures in adult patients, but the safety of PEG sealant in the pediatric population has not been shown. METHODS ... Full text Link to item Cite

Evaluation of complication rates of pediatric spinal procedures in which a polyethylene glycol sealant was used.

Journal Article J Neurosurg Pediatr · March 2014 OBJECT: Cerebrospinal fluid leakage following durotomy in spinal surgery can lead to significant patient morbidity and mortality, including meningitis and even death. Usage of a polyethylene glycol (PEG) sealant in combination with standard closure techniq ... Full text Link to item Cite

Combination of anti-VEGF therapy and temozolomide in two experimental human glioma models.

Journal Article J Neurooncol · January 2014 Anti-angiogenic agents, such as bevacizumab (BEV), can induce normalization of the blood brain barrier, which may influence the penetration and activity of a co-administered cytotoxic drug. However, it is unknown whether this effect is associated with a be ... Full text Link to item Cite

Glycerol rhizotomy via a retrosigmoid approach as an alternative treatment for trigeminal neuralgia.

Journal Article Clin Neurol Neurosurg · December 2013 OBJECTIVES: Trigeminal neuralgia is a sensory nerve disorder characterized by lancinating pain and treated most commonly with carbamazepine, rhizotomy treatment, or open surgical management with microvascular decompression. We describe a novel technique to ... Full text Link to item Cite

Profiling the dynamics of a human phosphorylome reveals new components in HGF/c-Met signaling.

Journal Article PLoS One · 2013 Protein phosphorylation is a dynamic and reversible event that greatly influences cellular function. Identifying the key regulatory elements that determine cellular phenotypes during development and oncogenesis requires the ability to dynamically monitor p ... Full text Open Access Link to item Cite

EphB2 receptor controls proliferation/migration dichotomy of glioblastoma by interacting with focal adhesion kinase.

Journal Article Oncogene · December 13, 2012 Glioblastoma multiforme (GBM) is the most frequent and aggressive primary brain tumors in adults. Uncontrolled proliferation and abnormal cell migration are two prominent spatially and temporally disassociated characteristics of GBMs. In this study, we inv ... Full text Open Access Link to item Cite

Pediatric spinal trauma

Journal Article Neurosurgery Quarterly · May 1, 2012 Pediatric spinal trauma is relatively rare with roughly 5% of injuries occurring in this group. Cervical spinal trauma is most common in the pediatric population, followed by thoracic and lumbar injuries. The biomechanics of the evolving pediatric anatomy ... Full text Cite

Abstract 4311: EphB2 receptor controls proliferation/migration dichotomy of glioblastoma by interacting with focal adhesion kinase

Journal Article Cancer Research · April 15, 2012 AbstractGlioblastoma multiforme (GBM) are the most frequent and aggressive primary brain tumors in adults. Uncontrolled proliferation and abnormal cell migration are two prominent spatially and temporally di ... Full text Cite

Castleman's disease of the sacral spine.

Journal Article Clin Neurol Neurosurg · April 2012 Full text Link to item Cite

Anatomy and physiology of the cerebrospinal fluid system

Chapter · January 1, 2012 In the average human, the total body water is about 60% of the body weight [1]. The brain is highly sensitive to the amount and distribution of water in the intracranial space. The intracranial space enclosing the brain has a capacity of about 1600–1700 ml ... Full text Cite

Core imaging in adult hydrocephalus

Chapter · January 1, 2012 Advances in neuroimaging have greatly improved the management of hydrocephalus. The various imaging modalities are useful in confirming the diagnosis, determining the etiology of hydrocephalus, providing intraoperative guidance, and improving the follow-up ... Full text Cite

Hydrocephalus shunt procedures

Chapter · January 1, 2012 Cerebrospinal fluid (CSF) shunting is one of the most common neurosurgical procedures performed, and has been used for many years with excellent results in the treatment of multiple forms of hydrocephalus in both pediatric and adult patients. However, desp ... Full text Cite

Normal pressure hydrocephalus syndrome secondary to hemorrhage, infection, and malignancy

Chapter · January 1, 2012 Normal pressure hydrocephalus (NPH) is characterized by the presence of ventriculomegaly associated with the triad of gait, memory, and urinary problems in the absence of a detectable cause. There is a group of individuals with longstanding compensated hyd ... Full text Cite

PTEN reconstitution alters glioma responses to c-Met pathway inhibition.

Journal Article Anticancer Drugs · October 2011 Mutations/deletions of the tumor-suppressor phosphatase and tensin homolog PTEN result in PI3K/Akt pathway hyperactivation and potentially alter oncogenic responses to targeted receptor tyrosine kinase inhibitors. We previously showed that hepatocyte growt ... Full text Link to item Cite

Regulation of glioblastoma stem cells by retinoic acid: role for Notch pathway inhibition.

Journal Article Oncogene · August 4, 2011 It is necessary to understand mechanisms by which differentiating agents influence tumor-initiating cancer stem cells. Toward this end, we investigated the cellular and molecular responses of glioblastoma stem-like cells (GBM-SCs) to all-trans retinoic aci ... Full text Link to item Cite

Prevention of facial pressure ulcers using the Mayfield clamp for sacral tumor resection.

Journal Article J Neurosurg Spine · January 2011 Sacral neoplasm resection is managed via partial or total sacrectomy that is performed via the Kraske approach. The combination of the patients positioning and the relatively long operative time required for this procedure increase the risk of pressure ulc ... Full text Link to item Cite

Neuro-oncology: unmasking the multiforme in glioblastoma.

Journal Article Nat Rev Neurol · June 2010 Classification of glioblastomas into various molecular entities is required for the successful application of targeted therapeutics and personalized cancer therapy. Analyses of gene expression, genomic mutations and DNA copy number identified four molecula ... Full text Link to item Cite

Cyr61 mediates hepatocyte growth factor-dependent tumor cell growth, migration, and Akt activation.

Journal Article Cancer Res · April 1, 2010 Certain tumor cell responses to the growth factor-inducible early response gene product CCN1/Cyr61 overlap with those induced by the hepatocyte growth factor (HGF)/c-Met signaling pathway. In this study, we investigate if Cyr61 is a downstream effector of ... Full text Link to item Cite

Defining the next generation journal: The NLM-Elsevier interactive publications experiment.

Journal Article Inf Serv Use · January 1, 2010 OBJECTIVE: A unique collaborative project to identify interactive enhancements to conventional-print journal articles, and to evaluate their contribution to readers' learning and satisfaction. HYPOTHESIS: It was hypothesized that (a) the enhanced article w ... Full text Link to item Cite

Camptothecin and Fas receptor agonists synergistically induce medulloblastoma cell death: ROS-dependent mechanisms.

Journal Article Anticancer Drugs · October 2009 Medulloblastoma, a common malignant pediatric brain tumor, is highly resistant to death receptor-mediated apoptosis despite death receptor expression by tumor cells. Developing new strategies to overcome this resistance to death receptor activation could p ... Full text Link to item Cite

Risk factors for pancreatic leak after distal pancreatectomy.

Journal Article Ann Surg · August 2009 INTRODUCTION: Pancreatic leak (PL) remains a major cause of postoperative morbidity in patients undergoing pancreatic resection. We sought to evaluate the incidence of and identify risk factors for the development of PL in patients undergoing distal pancre ... Full text Link to item Cite

EGFRvIII and c-Met pathway inhibitors synergize against PTEN-null/EGFRvIII+ glioblastoma xenografts.

Journal Article Mol Cancer Ther · July 2009 Receptor tyrosine kinase (RTK) systems, such as hepatocyte growth factor (HGF) and its receptor c-Met, and epidermal growth factor receptor (EGFR), are responsible for the malignant progression of multiple solid tumors. Recent research shows that these RTK ... Full text Link to item Cite

A review on the management of epilepsy associated with hypothalamic hamartomas.

Journal Article Childs Nerv Syst · April 2009 INTRODUCTION: Hypothalamic hamartomas are rare congenital malformations located in the region of the tuber cinereum and third ventricle. Patients may be asymptomatic, but the usual presentation is gelastic seizures, precocious puberty, and/or developmental ... Full text Link to item Cite

Hepatocyte growth factor enhances death receptor-induced apoptosis by up-regulating DR5.

Journal Article BMC Cancer · November 7, 2008 BACKGROUND: Hepatocyte growth factor (HGF) and its receptor c-MET are commonly expressed in malignant gliomas and embryonic neuroectodermal tumors including medulloblastoma and appear to play an important role in the growth and dissemination of these malig ... Full text Open Access Link to item Cite

Evaluation and treatment of patients with suspected normal pressure hydrocephalus on long-term warfarin anticoagulation therapy.

Journal Article Neurosurgery · March 2007 OBJECTIVE: Long-term anticoagulation is often considered a contraindication to shunt surgery for elderly patients with normal pressure hydrocephalus (NPH). However, no studies have investigated this question. METHODS: We evaluated 25 patients who were taki ... Full text Link to item Cite