Skip to main content

William Everett Copeland

Adjunct Professor in the Department of Psychiatry and Behavioral Sciences
Psychiatry, Child & Family Mental Health & Community Psychiatry
Box 3454 Med Ctr, Durham, NC
905 W Main St, Ste 22, Durham, NC

Selected Publications


Family cash transfers in childhood and birthing persons and birth outcomes later in life.

Journal Article SSM Popul Health · March 2024 Much literature in the US documents an intergenerational transmission of birthing person and perinatal morbidity in socioeconomically disadvantaged groups. A separate line of work indicates that family cash transfers may improve life chances of low-income ... Full text Link to item Cite

Commentary: Integrative, multi-level explanatory models are needed to understand recent trends in sex, gender, and internalizing conditions, reflections on Keyes and Platt (2023).

Journal Article J Child Psychol Psychiatry · February 8, 2024 Keyes' and Platt's (The Journal of Child Psychology and Psychiatry, 2023) review provides much-needed systematic evidence about why internalizing symptoms have increased and it clarifies the role of novel risk factors. The findings highlight that multiple ... Full text Link to item Cite

The substance use behaviors change of first-year college students before and during COVID-19 pandemic.

Journal Article J Am Coll Health · January 16, 2024 OBJECTIVE: This article tests the substance use behaviors of college students before and during COVID-19 pandemic. METHODS: In-depth assessment and nightly survey data was used from a longitudinal study (n = 675) which examined student substance use during ... Full text Link to item Cite

Comparative assessment of the feasibility and validity of daily activity space in urban and non-urban settings.

Journal Article PLoS One · 2024 Activity space research explores the behavioral impact of the spaces people move through in daily life. This research has focused on urban settings, devoting little attention to non-urban settings. We examined the validity of the activity space method, com ... Full text Link to item Cite

The Impact of Childhood Mental Health and Substance Use on Methylation Aging Into Adulthood.

Journal Article J Am Acad Child Adolesc Psychiatry · December 27, 2023 OBJECTIVE: To test whether childhood mental health symptoms, substance use, and early adversity accelerate the rate of DNA methylation (DNAm) aging from adolescence to adulthood. METHOD: DNAm was assayed from blood samples in 381 participants in both adole ... Full text Link to item Cite

Cultural contributions to adults' self-rated mental health problems and strengths: 7 culture clusters, 28 societies, 16 906 adults.

Journal Article Psychol Med · December 2023 BACKGROUND: It is unknown how much variation in adult mental health problems is associated with differences between societal/cultural groups, over and above differences between individuals. METHODS: To test these relative contributions, a consortium of ind ... Full text Link to item Cite

Association between relative age at school and persistence of ADHD in prospective studies: an individual participant data meta-analysis.

Journal Article Lancet Psychiatry · December 2023 BACKGROUND: The youngest children in a school class are more likely than the oldest to be diagnosed with ADHD, but this relative age effect is less frequent in older than in younger school-grade children. However, no study has explored the association betw ... Full text Link to item Cite

Adult Mental Health, Substance Use Disorders, and Functional Outcomes of Children Resilient to Early Adversity.

Journal Article Am J Psychiatry · December 1, 2023 OBJECTIVE: Some children are unaffected by mental illness despite exposure to childhood adversity. These children are typically considered resilient. The objective of this study was to follow up such resilient children in adulthood to characterize mental h ... Full text Link to item Cite

Violent Experiences and Patterns of Firearm Ownership From Childhood to Young Adulthood.

Journal Article JAMA Netw Open · October 2, 2023 IMPORTANCE: Young adults in their 20s are at high relative risk for self- and other-directed firearm injury, but little is known about gun access patterns for this group. OBJECTIVE: To describe the longitudinal patterns of firearm access from childhood to ... Full text Link to item Cite

The Vermont Family Based Approach in Primary Care Pediatrics: Effects on Children's and Parents' Emotional and Behavioral Problems and Parents' Health-Related Quality of Life.

Journal Article Child Psychiatry Hum Dev · October 2023 This randomized controlled trial tested the Vermont Family Based Approach (VFBA) in primary care pediatrics. The VFBA is a model of healthcare delivery that shifts the focus from the individual to the family, emphasizes emotional and behavioral health, and ... Full text Link to item Cite

Pubertal timing moderates the same-day coupling between family hassles and negative affect in girls and boys.

Journal Article Dev Psychopathol · October 2023 This study examined the association between pubertal timing, daily affect, conduct problems, and the exposure to hassles across family, peer, and school contexts. Adolescents (M age = 12.27; 49.7% female; 62.6% White) completed ecological momentary assessm ... Full text Link to item Cite

Early life adversity and psychopathology in preschoolers: mechanisms and moderators.

Journal Article Eur Child Adolesc Psychiatry · September 19, 2023 Developmental theories suggest that exposure to early life adversity (ELA) alters developing emotional response systems, predicting risk for psychopathology across the life span. The present study examines whether negative emotionality (NE), a trait-like m ... Full text Link to item Cite

Intergenerational Effects of a Family Cash Transfer on the Home Environment.

Journal Article J Am Acad Child Adolesc Psychiatry · August 22, 2023 OBJECTIVE: A natural experiment that provided income supplements to families has been associated with beneficial outcomes for children that persisted into adulthood. The children in this study are now adults, and many are parents. METHOD: The study builds ... Full text Link to item Cite

Distinct Associations of Deprivation and Threat With Alterations in Brain Structure in Early Childhood.

Journal Article J Am Acad Child Adolesc Psychiatry · August 2023 OBJECTIVE: The dimensional model of adversity and psychopathology hypothesizes deprivation and threat impact distinct neurobiological pathways, such as brain structure. This hypothesis has not been examined longitudinally or in young children. This study t ... Full text Link to item Cite

Prospective Associations of Childhood Housing Insecurity With Anxiety and Depression Symptoms During Childhood and Adulthood.

Journal Article JAMA Pediatr · August 1, 2023 IMPORTANCE: Childhood housing insecurity has dramatically increased in the US in recent decades, but whether an association with adverse mental health outcomes exists after adjusting for repeated measures of childhood poverty is unclear. OBJECTIVE: To test ... Full text Link to item Cite

Methylome-wide association study of anxiety disorders.

Journal Article Mol Psychiatry · August 2023 Anxiety Disorders (ANX) such as panic disorder, generalized anxiety disorder, and phobias, are highly prevalent conditions that are moderately heritable. Evidence suggests that DNA methylation may play a role, as it is involved in critical adaptations to c ... Full text Link to item Cite

Adult criminal outcomes of juvenile justice involvement.

Journal Article Psychol Med · June 2023 BACKGROUND: The juvenile justice system in the USA adjudicates over seven hundred thousand youth in the USA annually with significant behavioral offenses. This study aimed to test the effect of juvenile justice involvement on adult criminal outcomes. METHO ... Full text Link to item Cite

Day-to-day variation in adolescent food insecurity.

Journal Article Child Youth Serv Rev · June 2023 This study examined differences in both average and variability in daily adolescent food insecurity, by adolescents' levels of economic disadvantage and race/ethnicity. We used data from a 14-day ecological momentary assessment of 395 adolescents enrolled ... Full text Link to item Cite

Family cash transfers in childhood and birthing persons and birth outcomes later in life.

Journal Article SSM Popul Health · March 2024 Much literature in the US documents an intergenerational transmission of birthing person and perinatal morbidity in socioeconomically disadvantaged groups. A separate line of work indicates that family cash transfers may improve life chances of low-income ... Full text Link to item Cite

Commentary: Integrative, multi-level explanatory models are needed to understand recent trends in sex, gender, and internalizing conditions, reflections on Keyes and Platt (2023).

Journal Article J Child Psychol Psychiatry · February 8, 2024 Keyes' and Platt's (The Journal of Child Psychology and Psychiatry, 2023) review provides much-needed systematic evidence about why internalizing symptoms have increased and it clarifies the role of novel risk factors. The findings highlight that multiple ... Full text Link to item Cite

The substance use behaviors change of first-year college students before and during COVID-19 pandemic.

Journal Article J Am Coll Health · January 16, 2024 OBJECTIVE: This article tests the substance use behaviors of college students before and during COVID-19 pandemic. METHODS: In-depth assessment and nightly survey data was used from a longitudinal study (n = 675) which examined student substance use during ... Full text Link to item Cite

Comparative assessment of the feasibility and validity of daily activity space in urban and non-urban settings.

Journal Article PLoS One · 2024 Activity space research explores the behavioral impact of the spaces people move through in daily life. This research has focused on urban settings, devoting little attention to non-urban settings. We examined the validity of the activity space method, com ... Full text Link to item Cite

The Impact of Childhood Mental Health and Substance Use on Methylation Aging Into Adulthood.

Journal Article J Am Acad Child Adolesc Psychiatry · December 27, 2023 OBJECTIVE: To test whether childhood mental health symptoms, substance use, and early adversity accelerate the rate of DNA methylation (DNAm) aging from adolescence to adulthood. METHOD: DNAm was assayed from blood samples in 381 participants in both adole ... Full text Link to item Cite

Cultural contributions to adults' self-rated mental health problems and strengths: 7 culture clusters, 28 societies, 16 906 adults.

Journal Article Psychol Med · December 2023 BACKGROUND: It is unknown how much variation in adult mental health problems is associated with differences between societal/cultural groups, over and above differences between individuals. METHODS: To test these relative contributions, a consortium of ind ... Full text Link to item Cite

Association between relative age at school and persistence of ADHD in prospective studies: an individual participant data meta-analysis.

Journal Article Lancet Psychiatry · December 2023 BACKGROUND: The youngest children in a school class are more likely than the oldest to be diagnosed with ADHD, but this relative age effect is less frequent in older than in younger school-grade children. However, no study has explored the association betw ... Full text Link to item Cite

Adult Mental Health, Substance Use Disorders, and Functional Outcomes of Children Resilient to Early Adversity.

Journal Article Am J Psychiatry · December 1, 2023 OBJECTIVE: Some children are unaffected by mental illness despite exposure to childhood adversity. These children are typically considered resilient. The objective of this study was to follow up such resilient children in adulthood to characterize mental h ... Full text Link to item Cite

Violent Experiences and Patterns of Firearm Ownership From Childhood to Young Adulthood.

Journal Article JAMA Netw Open · October 2, 2023 IMPORTANCE: Young adults in their 20s are at high relative risk for self- and other-directed firearm injury, but little is known about gun access patterns for this group. OBJECTIVE: To describe the longitudinal patterns of firearm access from childhood to ... Full text Link to item Cite

The Vermont Family Based Approach in Primary Care Pediatrics: Effects on Children's and Parents' Emotional and Behavioral Problems and Parents' Health-Related Quality of Life.

Journal Article Child Psychiatry Hum Dev · October 2023 This randomized controlled trial tested the Vermont Family Based Approach (VFBA) in primary care pediatrics. The VFBA is a model of healthcare delivery that shifts the focus from the individual to the family, emphasizes emotional and behavioral health, and ... Full text Link to item Cite

Pubertal timing moderates the same-day coupling between family hassles and negative affect in girls and boys.

Journal Article Dev Psychopathol · October 2023 This study examined the association between pubertal timing, daily affect, conduct problems, and the exposure to hassles across family, peer, and school contexts. Adolescents (M age = 12.27; 49.7% female; 62.6% White) completed ecological momentary assessm ... Full text Link to item Cite

Early life adversity and psychopathology in preschoolers: mechanisms and moderators.

Journal Article Eur Child Adolesc Psychiatry · September 19, 2023 Developmental theories suggest that exposure to early life adversity (ELA) alters developing emotional response systems, predicting risk for psychopathology across the life span. The present study examines whether negative emotionality (NE), a trait-like m ... Full text Link to item Cite

Intergenerational Effects of a Family Cash Transfer on the Home Environment.

Journal Article J Am Acad Child Adolesc Psychiatry · August 22, 2023 OBJECTIVE: A natural experiment that provided income supplements to families has been associated with beneficial outcomes for children that persisted into adulthood. The children in this study are now adults, and many are parents. METHOD: The study builds ... Full text Link to item Cite

Distinct Associations of Deprivation and Threat With Alterations in Brain Structure in Early Childhood.

Journal Article J Am Acad Child Adolesc Psychiatry · August 2023 OBJECTIVE: The dimensional model of adversity and psychopathology hypothesizes deprivation and threat impact distinct neurobiological pathways, such as brain structure. This hypothesis has not been examined longitudinally or in young children. This study t ... Full text Link to item Cite

Prospective Associations of Childhood Housing Insecurity With Anxiety and Depression Symptoms During Childhood and Adulthood.

Journal Article JAMA Pediatr · August 1, 2023 IMPORTANCE: Childhood housing insecurity has dramatically increased in the US in recent decades, but whether an association with adverse mental health outcomes exists after adjusting for repeated measures of childhood poverty is unclear. OBJECTIVE: To test ... Full text Link to item Cite

Methylome-wide association study of anxiety disorders.

Journal Article Mol Psychiatry · August 2023 Anxiety Disorders (ANX) such as panic disorder, generalized anxiety disorder, and phobias, are highly prevalent conditions that are moderately heritable. Evidence suggests that DNA methylation may play a role, as it is involved in critical adaptations to c ... Full text Link to item Cite

Adult criminal outcomes of juvenile justice involvement.

Journal Article Psychol Med · June 2023 BACKGROUND: The juvenile justice system in the USA adjudicates over seven hundred thousand youth in the USA annually with significant behavioral offenses. This study aimed to test the effect of juvenile justice involvement on adult criminal outcomes. METHO ... Full text Link to item Cite

Day-to-day variation in adolescent food insecurity.

Journal Article Child Youth Serv Rev · June 2023 This study examined differences in both average and variability in daily adolescent food insecurity, by adolescents' levels of economic disadvantage and race/ethnicity. We used data from a 14-day ecological momentary assessment of 395 adolescents enrolled ... Full text Link to item Cite

Associations of preschool reactive bed-sharing with sociodemographic factors, sleep disturbance, and psychopathology.

Journal Article Child Adolesc Psychiatry Ment Health · May 17, 2023 OBJECTIVE: To advance understanding of early childhood bed-sharing and its clinical significance, we examined reactive bed-sharing rates, sociodemographic correlates, persistence, and concurrent and longitudinal associations with sleep disturbances and psy ... Full text Link to item Cite

Intergenerational effects of the Fast Track intervention on the home environment: A randomized control trial.

Journal Article J Child Psychol Psychiatry · May 2023 BACKGROUND: Maladaptive family environments harm child development and are passed across generations. Childhood interventions may break this intergenerational cycle by improving the family environments children form as adults. The present study investigate ... Full text Link to item Cite

Defining despair: Assessing the multidimensionality of despair and its association with suicidality and substance use in early to middle adulthood.

Journal Article Soc Sci Med · March 2023 Despite considerable scientific interest in documenting growing despair among U.S. adults, far less attention has been paid to defining despair and identifying appropriate measures. Emerging perspectives from social science and psychiatry outline a compreh ... Full text Link to item Cite

Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders.

Journal Article Nat Ment Health · March 2023 Genetic liability to substance use disorders can be parsed into loci that confer general or substance-specific addiction risk. We report a multivariate genome-wide association meta-analysis that disaggregates general and substance-specific loci for publish ... Full text Link to item Cite

Fast Track intervention effects on family formation.

Journal Article J Fam Psychol · February 2023 The present study examines whether the Fast Track (FT) intervention, a 10-year randomized controlled trial with children at risk for conduct problems, affects family formation in adulthood, as indexed by partnerships, parenthood, and family structure, and ... Full text Link to item Cite

Childhood loneliness as a specific risk factor for adult psychiatric disorders.

Journal Article Psychol Med · January 2023 BACKGROUND: Loneliness is a major risk factor for both psychological disturbance and poor health outcomes in adults. This study aimed to assess whether childhood loneliness is associated with a long-term disruption in mental health that extends into adulth ... Full text Link to item Cite

The HOME-21: A revised measure of the home environment for the 21st century tested in two independent samples.

Journal Article Psychol Assess · January 2023 For decades, the Home Observation for Measurement of the Environment (HOME) has been the most widely used measure of children's home environments. This report provides a revised version of the HOME-Short Form, the HOME-21, reflecting historical changes in ... Full text Link to item Cite

Parental supervision positively impacts children's economic prospects two decades later: A prospective longitudinal study.

Journal Article PLoS One · 2023 IMPORTANCE: Upward income mobility is associated with better health outcomes and reduced stress. However, opportunities are unequally distributed, particularly so for those in rural communities and whose family have lower educational attainment. OBJECTIVE: ... Full text Link to item Cite

Associations between Configurations of Childhood Adversity and Adult Mental Health Disorder Outcomes

Journal Article Society and Mental Health · January 1, 2023 The life course perspective and cumulative inequality theory suggest that childhood adversity, occurring during a sensitive period of the life course, can have long-term consequences for adult mental health and well-being. Yet, the long-term influence of a ... Full text Cite

DNA methylation biomarkers of alcohol use disorder

Conference ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH · 2023 Cite

Gun violence among young adults with a juvenile crime record in North Carolina: Implications for firearm restrictions based on age and risk.

Journal Article Prev Med · December 2022 Youth who acquire a juvenile crime record may be at increased risk of perpetrating gun violence as adults. North Carolina and 22 other states permit young adults who were adjudicated by a juvenile court - even for some felony-equivalent offenses - to legal ... Full text Link to item Cite

Adolescent depression and adult labor market marginalization: a longitudinal cohort study.

Journal Article Eur Child Adolesc Psychiatry · November 2022 Adolescent depression is linked to adult ill-health and functional impairment, but recent research suggests that individual/contextual factors might account for this association. This study aimed to test whether the clinical heterogeneity of adolescent dep ... Full text Link to item Cite

Parental perception of mental health needs in young children.

Journal Article Child Adolesc Ment Health · November 2022 BACKGROUND: There is evidence of unmet psychiatric needs in children under 6. These young children are dependent on their parents to identify their mental health needs. This study tested child and parent associations with parent perception of young child m ... Full text Link to item Cite

Early adversities accelerate epigenetic aging into adulthood: a 10-year, within-subject analysis.

Journal Article J Child Psychol Psychiatry · November 2022 BACKGROUND: Longitudinal studies are needed to clarify whether early adversities are associated with advanced methylation age or if they actually accelerate methylation aging. This study test whether different dimensions of childhood adversity accelerate b ... Full text Link to item Cite

Identifying adolescents at risk for depression: Assessment of a global prediction model in the Great Smoky Mountains Study.

Journal Article J Psychiatr Res · November 2022 The Identifying Depression Early in Adolescence Risk Score (IDEA-RS) has been externally assessed in samples from four continents, but North America is lacking. Our aim here was to evaluate the performance of the IDEA-RS in predicting future onset of Major ... Full text Link to item Cite

Disentangling the "who" and "when" of parents' depressive symptoms: A daily diary study analysis.

Journal Article J Psychopathol Clin Sci · October 2022 Parents' depressive symptoms vary across days, but factors predicting this fluctuation are not well understood. The present study utilized ecological momentary assessments to capture 1620 days of parents' lived experience in a diverse sample of 146 mothers ... Full text Link to item Cite

Long-term Outcomes of Childhood Family Income Supplements on Adult Functioning.

Journal Article JAMA Pediatr · October 1, 2022 IMPORTANCE: During an ongoing longitudinal cohort study, a casino opening created a natural cash transfer experiment. Some participating families received income supplements, and others did not. The children in this study are now adults. OBJECTIVE: To asse ... Full text Link to item Cite

1.79 Parental Supervision Positively Impacts Their Children’s Income Two Decades Later

Journal Article Journal of the American Academy of Child & Adolescent Psychiatry · October 2022 Full text Cite

METHYLOME-WIDE ASSOCIATION STUDY OF ANXIETY DISORDERS

Journal Article European Neuropsychopharmacology · October 2022 Full text Cite

Do "Real World" Childhood Mental Health Services Reduce Risk for Adult Psychiatric Disorders?

Journal Article J Am Acad Child Adolesc Psychiatry · August 2022 OBJECTIVE: This study tested the "intervention as prevention" hypothesis: that treatment of childhood psychopathology in the community might reduce risk for adult psychopathology. METHOD: Analyses were based on a prospective, population-based study of 1,42 ... Full text Link to item Cite

DNA methylation signatures of childhood trauma predict psychiatric disorders and other adverse outcomes 17 years after exposure.

Journal Article Mol Psychiatry · August 2022 Childhood trauma is robustly linked to a broad range of adverse outcomes with consequences persisting far into adulthood. We conducted a prospective longitudinal study to predict psychiatric disorders and other adverse outcomes from trauma-related methylat ... Full text Link to item Cite

A methylation study implicates the rewiring of brain neural circuits during puberty in the emergence of sex differences in depression symptoms.

Journal Article J Child Psychol Psychiatry · July 2022 BACKGROUND: Women are 1.5-3 times more likely to suffer from depression than men. This sex bias first emerges during puberty and then persists across the reproductive years. As the cause remains largely elusive, we performed a methylation-wide association ... Full text Link to item Cite

Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms.

Journal Article J Am Acad Child Adolesc Psychiatry · July 2022 OBJECTIVE: To investigate the genetic architecture of internalizing symptoms in childhood and adolescence. METHOD: In 22 cohorts, multiple univariate genome-wide association studies (GWASs) were performed using repeated assessments of internalizing symptom ... Full text Link to item Cite

A Pilot Trial of a Health Promotion and Illness Prevention Paradigm in the Perinatal Period.

Journal Article Matern Child Health J · June 2022 OBJECTIVES: This is a pilot study of the Vermont Family Based Approach, an innovative health promotion program designed to address behavioral health prevention in primary care, adapted for perinatal women. We aimed to determine the acceptability of the int ... Full text Link to item Cite

Association of adversity with psychopathology in early childhood: Dimensional and cumulative approaches.

Journal Article Depress Anxiety · June 2022 BACKGROUND: The association between adversity and psychopathology in adolescents and adults is characterized by equifinality. These associations, however, have not been assessed during early childhood when psychopathology first emerges. Defining adversity ... Full text Link to item Cite

Impact of dimensions of early adversity on adult health and functioning: A 2-decade, longitudinal study.

Journal Article Dev Psychopathol · May 2022 Recent neurodevelopmental and evolutionary theories offer strong theoretical rationales and some empirical evidence to support the importance of specific dimensions of early adversity. However, studies have often been limited by omission of other adversity ... Full text Link to item Cite

COVID-related distress, mental health, and substance use in adolescents and young adults.

Journal Article Child Adolesc Ment Health · May 2022 BACKGROUND: This study examined the impact of COVID-related disruptions on mental health and substance use in young people residing in a state with an initially lower COVID burden and earlier reopening of in-person learning than other states. METHODS: Data ... Full text Link to item Cite

Adult Psychiatric, Substance, and Functional Outcomes of Different Definitions of Early Cannabis Use.

Journal Article J Am Acad Child Adolesc Psychiatry · April 2022 OBJECTIVE: Research on associations of early cannabis use with adult functioning reports mixed findings. This may be due, in part, to wide variations in the definitions of early cannabis use. This study aims to compare associations of 4 commonly used defin ... Full text Link to item Cite

Dual methylation and hydroxymethylation study of alcohol use disorder.

Journal Article Addiction biology · March 2022 Using an integrative, multi-tissue design, we sought to characterize methylation and hydroxymethylation changes in blood and brain associated with alcohol use disorder (AUD). First, we used epigenomic deconvolution to perform cell-type-specific methylome-w ... Full text Cite

A Digital Therapeutic Intervention Delivering Biofeedback for Panic Attacks (PanicMechanic): Feasibility and Usability Study.

Journal Article JMIR Form Res · February 3, 2022 BACKGROUND: Panic attacks (PAs) are an impairing mental health problem that affects >11% of adults every year. PAs are episodic, and it is difficult to predict when or where they may occur; thus, they are challenging to study and treat. OBJECTIVE: The aim ... Full text Link to item Cite

Ecological Momentary Assessment of Physical Activity and Wellness Behaviors in College Students Throughout a School Year: Longitudinal Naturalistic Study.

Journal Article JMIR Public Health Surveill · January 4, 2022 BACKGROUND: The Wellness Environment app study is a longitudinal study focused on promoting health in college students. OBJECTIVE: The two aims of this study were (1) to assess physical activity (PA) variation across the days of the week and throughout the ... Full text Link to item Cite

Daily wellness behaviors in college students across a school year.

Journal Article J Am Coll Health · 2022 Objective: To establish the prevalence of mood and wellness behaviors in college students across a school year. Methods: 1,554 college students (69.4% female; average age 18.8 years) were followed with daily surveys on wellness behaviors for the school yea ... Full text Link to item Cite

Music-Based Mentoring and Academic Improvement in High-Poverty Elementary Schools

Journal Article Journal of Youth Development · January 1, 2022 Recent research links disparities in children’s language-related brain function to poverty and its correlates. Such disparities are hypothesized to underlie achievement gaps between students from low-income families and more advantaged peers. Interventions ... Full text Cite

Methylomic Investigation of Problematic Adolescent Cannabis Use and Its Negative Mental Health Consequences.

Journal Article J Am Acad Child Adolesc Psychiatry · December 2021 OBJECTIVE: The impact of adolescent cannabis use is a pressing public health question owing to the high rates of use and links to negative outcomes. This study considered the association between problematic adolescent cannabis use and methylation. METHOD: ... Full text Link to item Cite

Impact of the COVID-19 pandemic on substance use among adults without children, parents, and adolescents.

Journal Article Addict Behav Rep · December 2021 Impact of the COVID-19 pandemic on alcohol and illicit substance use among adults without children, parents, and adolescents was investigated through two studies with five samples from independent ongoing U.S. longitudinal studies. In Study 1, 931 adults w ... Full text Open Access Link to item Cite

Frequent teenage cannabis use: Prevalence across adolescence and associations with young adult psychopathology and functional well-being in an urban cohort.

Journal Article Drug and alcohol dependence · November 2021 BackgroundAmidst cannabis legalization efforts and laws, we do not fully understand how the youngest frequent cannabis users fare during young adulthood. This study aims to 1) examine the prevalence of cannabis use during adolescence, and 2) inves ... Full text Cite

36.3 PERSONALITY TRAITS AND COPING DURING THE COVID-19 PANDEMIC

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2021 Full text Cite

Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course.

Journal Article Behav Genet · September 2021 We test whether genetic influences that explain individual differences in aggression in early life also explain individual differences across the life-course. In two cohorts from The Netherlands (N = 13,471) and Australia (N = 5628), polygenic scores (PGSs ... Full text Link to item Cite

Digital Phenotype for Childhood Internalizing Disorders: Less Positive Play and Promise for a Brief Assessment Battery.

Journal Article IEEE J Biomed Health Inform · August 2021 Childhood internalizing disorders, like anxiety and depression, are common, impairing, and difficult to detect. Universal childhood mental health screening has been recommended, but new technologies are needed to provide objective detection. Instrumented m ... Full text Link to item Cite

Childhood Gun Access, Adult Suicidality, and Crime.

Journal Article Pediatrics · August 2021 OBJECTIVES: To test the associations of childhood domestic gun access with adult criminality and suicidality. METHODS: Analyses were based on a 20+ year prospective, community-representative study of 1420 children, who were assessed up to 8 times during ch ... Full text Link to item Cite

Genetic association study of childhood aggression across raters, instruments, and age.

Journal Article Transl Psychiatry · July 30, 2021 Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assessors were included. ... Full text Link to item Cite

Psychiatry and Deaths of Despair.

Journal Article JAMA Psychiatry · July 1, 2021 Full text Link to item Cite

Associations of Childhood and Adolescent Depression With Adult Psychiatric and Functional Outcomes.

Journal Article J Am Acad Child Adolesc Psychiatry · May 2021 OBJECTIVE: Depression is common, impairing, and the leading cause of disease burden in youths. This study aimed to identify the effects of childhood/adolescent depression on a broad range of longer-term outcomes. METHOD: The analysis is based on the prospe ... Full text Link to item Cite

Prevalence and Childhood Precursors of Opioid Use in the Early Decades of Life.

Journal Article JAMA Pediatr · March 1, 2021 IMPORTANCE: Opioid use disorder and opioid deaths have increased dramatically in young adults in the US, but the age-related course or precursors to opioid use among young people are not fully understood. OBJECTIVE: To document age-related changes in opioi ... Full text Link to item Cite

Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies.

Journal Article Addict Biol · January 2021 Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol ... Full text Link to item Cite

Impact of COVID-19 Pandemic on College Student Mental Health and Wellness.

Journal Article J Am Acad Child Adolesc Psychiatry · January 2021 OBJECTIVE: To test the impact of the coronavirus disease 2019 (COVID) pandemic on the emotions, behavior, and wellness behaviors of first-year college students. METHOD: A total of 675 first-year university students completed a full assessment of behavioral ... Full text Link to item Cite

Personality trait predictors of adjustment during the COVID pandemic among college students.

Journal Article PLoS One · 2021 Personality traits have been found to be related to a variety of health outcomes. The aim of this study was to examine how personality traits were associated with adjustment to the COVID pandemic in college students. The sample included 484 first-year univ ... Full text Link to item Cite

Longitudinal associations of trauma exposure with disordered eating: Lessons from the Great Smoky Mountains Study.

Journal Article Eat Disord · 2021 Disordered eating is prevalent among trauma survivors, yet little is known about mechanisms underlying this relation. We explored cross-sectional and longitudinal associations of trauma exposure and posttraumatic stress disorder symptoms (PTSD) with disord ... Full text Link to item Cite

Correction: Personality trait predictors of adjustment during the COVID pandemic among college students.

Journal Article PLoS One · 2021 [This corrects the article DOI: 10.1371/journal.pone.0248895.]. ... Full text Link to item Cite

A large-scale genome-wide association study meta-analysis of cannabis use disorder.

Journal Article Lancet Psychiatry · December 2020 BACKGROUND: Variation in liability to cannabis use disorder has a strong genetic component (estimated twin and family heritability about 50-70%) and is associated with negative outcomes, including increased risk of psychopathology. The aim of the study was ... Full text Link to item Cite

Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium.

Journal Article Mol Psychiatry · August 2020 To provide insights into the biology of opioid dependence (OD) and opioid use (i.e., exposure, OE), we completed a genome-wide analysis comparing 4503 OD cases, 4173 opioid-exposed controls, and 32,500 opioid-unexposed controls, including participants of E ... Full text Link to item Cite

Associations of Despair With Suicidality and Substance Misuse Among Young Adults.

Journal Article JAMA Netw Open · June 1, 2020 IMPORTANCE: Deaths of despair is a term that has recently been used to describe the increases in premature mortality from suicides, drug overdoses (particularly from opiates), and alcohol-related liver disease among US adults. Despite the use of the term d ... Full text Link to item Cite

Human Capital and Voting Behavior across Generations: Evidence from an Income Intervention

Journal Article American Political Science Review · May 1, 2020 Despite clear evidence of a sharp income gradient in voting participation, it remains unclear whether income truly causes voting. In this article, we investigate how exogenous increases in unearned income affect voting in U.S. elections for two generations ... Full text Cite

Error in Table.

Journal Article JAMA Netw Open · May 1, 2020 Full text Link to item Cite

Adolescent depression and subsequent earnings across early to middle adulthood: a 25-year longitudinal cohort study.

Journal Article Epidemiol Psychiatr Sci · April 29, 2020 AIMS: The few available studies on early-onset depression and future earnings offer ambiguous findings, and potential sources of heterogeneity are poorly understood. We examined the differences in adult earnings of males and females with and without a hist ... Full text Link to item Cite

Young Adolescents' Digital Technology Use, Perceived Impairments, and Well-Being in a Representative Sample.

Journal Article J Pediatr · April 2020 OBJECTIVE: To examine the cross-sectional associations between young adolescents' access, use, and perceived impairments related to digital technologies and their academic, psychological, and physical well-being. STUDY DESIGN: There were 2104 adolescents ( ... Full text Link to item Cite

Editorial: One Reason Why Not.

Journal Article J Am Acad Child Adolesc Psychiatry · February 2020 After declining modestly from 1999 to 2007, death rates from suicide in adolescents increased 56% from 2007 to 2016.1 Suicide continues to be the second leading cause of death in this age group. Risk factors for suicidal thoughts and behavior in adolescent ... Full text Link to item Cite

Income dividends and subjective survival in a Cherokee Indian cohort: a quasi-experiment.

Journal Article Biodemography Soc Biol · 2020 Persons with high temporal discounting tend to value immediate gratification over future gains. Low self-reported lifespan (SRL)-an individual's assessment of a relatively short future lifespan-concentrates in low-income populations and may reflect high te ... Full text Link to item Cite

Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent.

Journal Article Nat Commun · December 18, 2019 Body composition is often altered in psychiatric disorders. Using genome-wide common genetic variation data, we calculate sex-specific genetic correlations amongst body fat %, fat mass, fat-free mass, physical activity, glycemic traits and 17 psychiatric t ... Full text Link to item Cite

Early Pubertal Timing and Testosterone Associated With Higher Levels of Adolescent Depression in Girls.

Journal Article J Am Acad Child Adolesc Psychiatry · December 2019 OBJECTIVE: The prevalence of depression increases dramatically during puberty in girls. Earlier work in this sample reported that the sex steroids estradiol and testosterone were associated with increased depression in girls. Using three additional data wa ... Full text Link to item Cite

27.2 DISENTANGLING THE ROLES OF THREAT AND DEPRIVATION IN ASSOCIATIONS WITH EARLY CHILDHOOD PSYCHOPATHOLOGY

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2019 Full text Cite

27.1 NEURAL STRUCTURE IS INDEPENDENTLY PREDICTED BY DEPRIVATION AND THREAT IN EARLY CHILDHOOD

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2019 Full text Cite

27.3 ASSOCIATIONS OF CHILDHOOD THREAT AND DEPRIVATION ON ADULT PSYCHIATRIC DISORDERS AND FUNCTIONAL OUTCOMES

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2019 Full text Cite

2.56 UNWINDING ANXIETY: USING TECHNOLOGY TO PROMOTE MENTAL HEALTH IN COLLEGE STUDENTS

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2019 Full text Cite

4.2 RCT OF THE VERMONT FAMILY-BASED APPROACH (VFBA) IN PRIMARY CARE PEDIATRICS: ENGAGEMENT WITH HEALTH AND SUPPORT SERVICES

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2019 Full text Cite

4.57 EXAMINING TRENDS IN MOOD IN RELATION TO DAILY WELLNESS AND RISK BEHAVIORS IN A COLLEGE STUDENT POPULATION

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2019 Full text Cite

4.60 WELLNESS ENVIRONMENT HEALTH PROMOTION APP STUDY: LONGITUDINAL TRENDS IN ADULT SELF-REPORT SUBSCALE SCORES

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2019 Full text Cite

6.37 EFFECT OF THE HARMONY PROJECT MUSIC INSTRUCTION PROGRAM ON ACADEMIC OUTCOMES IN ELEMENTARY SCHOOL STUDENTS

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2019 Full text Cite

Association of Parental Incarceration With Psychiatric and Functional Outcomes of Young Adults.

Journal Article JAMA Netw Open · August 2, 2019 IMPORTANCE: In 2016, an estimated 8% of US children younger than 18 years had experienced the incarceration of a parent, and rates were substantially higher among children from racial and ethnic minority backgrounds and disadvantaged groups. Little is know ... Full text Open Access Link to item Cite

Conduct disorder.

Journal Article Nat Rev Dis Primers · June 27, 2019 Conduct disorder (CD) is a common and highly impairing psychiatric disorder that usually emerges in childhood or adolescence and is characterized by severe antisocial and aggressive behaviour. It frequently co-occurs with attention-deficit/hyperactivity di ... Full text Link to item Cite

Sensory Over-Responsivity: An Early Risk Factor for Anxiety and Behavioral Challenges in Young Children.

Journal Article J Abnorm Child Psychol · June 2019 Anxiety disorders are prevalent and significantly impact young children and their families. One hypothesized risk factor for anxiety is heightened responses to sensory input. Few studies have explored this hypothesis prospectively. This study had two goals ... Full text Link to item Cite

Does Despair Really Kill? A Roadmap for an Evidence-Based Answer.

Journal Article Am J Public Health · June 2019 Two seemingly associated demographic trends have generated considerable interest: income stagnation and rising premature mortality from suicides, drug poisoning, and alcoholic liver disease among US non-Hispanic Whites with low education. Economists interp ... Full text Link to item Cite

Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortium.

Journal Article Psychol Med · May 2019 BACKGROUND: Despite established clinical associations among major depression (MD), alcohol dependence (AD), and alcohol consumption (AC), the nature of the causal relationship between them is not completely understood. We leveraged genome-wide data from th ... Full text Link to item Cite

The University of Vermont Wellness Environment: Feasibility and Initial Results of a College Undergraduate Health-Promoting Program.

Journal Article Child Adolesc Psychiatr Clin N Am · April 2019 The University of Vermont Wellness Environment program is a neuroscience-inspired, incentive-based behavioral change program designed to improve health and academic outcomes in college-age students. The program uses health promotion and illness prevention ... Full text Link to item Cite

Perceived social status and mental health among young adolescents: Evidence from census data to cellphones.

Journal Article Dev Psychol · March 2019 Adolescents in the United States live amid high levels of concentrated poverty and increasing income inequality. Poverty is robustly linked to adolescents' mental health problems; however, less is known about how perceptions of their social status and expo ... Full text Link to item Cite

Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts.

Journal Article Am J Psychiatry · February 1, 2019 OBJECTIVE: Alcohol use disorders are common conditions that have enormous social and economic consequences. Genome-wide association analyses were performed to identify genetic variants associated with a proxy measure of alcohol consumption and alcohol misu ... Full text Link to item Cite

Genome-wide association study of alcohol use disorder identification test (AUDIT) scores in 20 328 research participants of European ancestry.

Journal Article Addict Biol · January 2019 Genetic factors contribute to the risk for developing alcohol use disorder (AUD). In collaboration with the genetics company 23andMe, Inc., we performed a genome-wide association study of the alcohol use disorder identification test (AUDIT), an instrument ... Full text Link to item Cite

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders.

Journal Article Nat Neurosci · December 2018 Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psy ... Full text Link to item Cite

Association of Childhood Trauma Exposure With Adult Psychiatric Disorders and Functional Outcomes.

Journal Article JAMA Netw Open · November 2, 2018 IMPORTANCE: Being exposed to trauma is a common childhood experience associated with symptoms and impairments in childhood. OBJECTIVE: To assess the association between cumulative childhood trauma exposure and adult psychiatric and functional outcomes. DES ... Full text Link to item Cite

Poster Abstracts

Conference Early Intervention in Psychiatry · October 2018 Full text Cite

GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia.

Journal Article Nat Neurosci · September 2018 Cannabis use is a heritable trait that has been associated with adverse mental health outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to date (N = 184,765), we identified eight genome-wide significant independent sin ... Full text Link to item Cite

How Does Household Income Affect Child Personality Traits and Behaviors?

Journal Article Am Econ Rev · March 2018 We examine the effects of a quasi-experimental unconditional household income transfer on child emotional and behavioral health and personality traits. Using longitudinal data, we find that there are large beneficial effects on children's emotional and beh ... Full text Link to item Cite

Measurement of Childhood Serious Emotional Disturbance: State of the Science and Issues for Consideration

Journal Article Journal of Emotional and Behavioral Disorders · December 1, 2017 Surveys suggest that between 4.3% and 11.5% of children living in the United States have a serious emotional disturbance (SED). SED is defined in the Federal Register, and federal block grants are allocated to states based on the prevalence of SED. Accurat ... Full text Cite

Predicting Persistent, Limited, and Delayed Problematic Cannabis Use in Early Adulthood: Findings From a Longitudinal Study.

Journal Article J Am Acad Child Adolesc Psychiatry · November 2017 OBJECTIVE: To identify risk profiles associated with patterns of problematic cannabis use in early adulthood. METHOD: Data came from 1,229 participants in the Great Smoky Mountains Study, a prospective 20-year cohort study from 1993 to 2015 that is represe ... Full text Link to item Cite

Adult Associations of Childhood Suicidal Thoughts and Behaviors: A Prospective, Longitudinal Analysis.

Journal Article J Am Acad Child Adolesc Psychiatry · November 2017 OBJECTIVE: Suicidal thoughts and behavior (STBs) have their peak period of onset in adolescence, but little is known about how such behavior is associated with later functioning. The aim of this study is to test whether childhood STBs are related to adult ... Full text Link to item Cite

Violence exposure and adolescents' same-day obesogenic behaviors: New findings and a replication.

Journal Article Soc Sci Med · September 2017 OBJECTIVE: To test whether exposure to violence is associated with same-day increases in obesogenic behaviors among young adolescents, including unhealthy food and beverage consumption, poor quality sleep, and lack of physical activity. METHODS: Young at-r ... Full text Link to item Cite

Tarlov Cyst Causing Sacral Insufficiency Fracture.

Journal Article Oper Neurosurg (Hagerstown) · June 1, 2017 BACKGROUND AND IMPORTANCE: Tarlov cysts, also known as perineural cysts, have been described as meningeal dilations of the spinal nerve root sheath between the peri- and endoneurium at the dorsal root ganglion. Most often they are found in the sacrum invol ... Full text Link to item Cite

Deep Sequencing of 71 Candidate Genes to Characterize Variation Associated with Alcohol Dependence.

Journal Article Alcohol Clin Exp Res · April 2017 BACKGROUND: Previous genomewide association studies (GWASs) have identified a number of putative risk loci for alcohol dependence (AD). However, only a few loci have replicated and these replicated variants only explain a small proportion of AD risk. Using ... Full text Link to item Cite

Cannabis Use and Disorder From Childhood to Adulthood in a Longitudinal Community Sample With American Indians.

Journal Article J Am Acad Child Adolesc Psychiatry · February 2017 OBJECTIVE: Recent changes in DSM criteria require new documentation of the prevalence and developmental sequences of cannabis use disorder (CUD). The goal of this study was to investigate the early course of DSM-5 CUD and its overlap with DSM-IV and consum ... Full text Link to item Cite

Long-Term Outcomes of Attention-Deficit/Hyperactivity Disorder and Conduct Disorder: A Systematic Review and Meta-Analysis.

Journal Article J Am Acad Child Adolesc Psychiatry · October 2016 OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) and conduct disorder (CD) are common externalizing disorders. Despite previous research demonstrating that both are longitudinally associated with adverse outcomes, there have been no systematic re ... Full text Link to item Cite

8.1 Disruptive Mood Dysregulation Disorder in Children With Autism Spectrum Disorder

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2016 Full text Cite

Psychiatric outcomes of bullying victimization: a study of discordant monozygotic twins.

Journal Article Psychol Med · July 2016 BACKGROUND: Bullying victimization in childhood is associated with a broad array of serious mental health disturbances, including anxiety, depression, and suicidal ideation and behavior. The key goal of this study was to evaluate whether bullying victimiza ... Full text Link to item Cite

Deep Sequencing of Three Loci Implicated in Large-Scale Genome-Wide Association Study Smoking Meta-Analyses.

Journal Article Nicotine Tob Res · May 2016 INTRODUCTION: Genome-wide association study meta-analyses have robustly implicated three loci that affect susceptibility for smoking: CHRNA5\CHRNA3\CHRNB4, CHRNB3\CHRNA6 and EGLN2\CYP2A6. Functional follow-up studies of these loci are needed to provide ins ... Full text Link to item Cite

The Great Smoky Mountains Study: developmental epidemiology in the southeastern United States.

Journal Article Soc Psychiatry Psychiatr Epidemiol · May 2016 AIMS: To describe the Great Smoky Mountains Study (GSMS). METHODS: GSMS is a longitudinal study of child psychiatric disorders that began in 1992 to look at need for mental health services in a rural area of the USA. Over 20 years it has expanded its range ... Full text Link to item Cite

Authors' Response.

Journal Article Pediatrics · January 2016 Full text Link to item Cite

Does childhood bullying predict eating disorder symptoms? A prospective, longitudinal analysis.

Journal Article Int J Eat Disord · December 2015 OBJECTIVE: Bullying is a common childhood experience with enduring psychosocial consequences. The aim of this study was to test whether bullying increases risk for eating disorder symptoms. METHOD: Ten waves of data on 1,420 participants between ages 9 and ... Full text Link to item Cite

Bully/victims: a longitudinal, population-based cohort study of their mental health.

Journal Article Eur Child Adolesc Psychiatry · December 2015 It has been suggested that those who both bully and are victims of bullying (bully/victims) are at the highest risk of adverse mental health outcomes. However, unknown is whether most bully/victims were bullies or victims first and whether being a bully/vi ... Full text Link to item Cite

Adult Functional Outcomes of Common Childhood Psychiatric Problems: A Prospective, Longitudinal Study.

Journal Article JAMA Psychiatry · September 2015 IMPORTANCE: Psychiatric problems are among the most common health problems of childhood. OBJECTIVE: To test whether these health problems adversely affect adult functioning even if the problems themselves do not persist. DESIGN, SETTING, AND PARTICIPANTS: ... Full text Link to item Cite

Psychological and Psychosocial Impairment in Preschoolers With Selective Eating.

Journal Article Pediatrics · September 2015 OBJECTIVE: We examined the clinical significance of moderate and severe selective eating (SE). Two levels of SE were examined in relation to concurrent psychiatric symptoms and as a risk factor for the emergence of later psychiatric symptoms. Findings are ... Full text Link to item Cite

Thresholds and accuracy in screening tools for early detection of psychopathology.

Journal Article J Child Psychol Psychiatry · September 2015 BACKGROUND: The accuracy of any screening instrument designed to detect psychopathology among children is ideally assessed through rigorous comparison to 'gold standard' tests and interviews. Such comparisons typically yield estimates of what we refer to a ... Full text Link to item Cite

Genome-Wide Meta-Analysis of Longitudinal Alcohol Consumption Across Youth and Early Adulthood.

Journal Article Twin Res Hum Genet · August 2015 The public health burden of alcohol is unevenly distributed across the life course, with levels of use, abuse, and dependence increasing across adolescence and peaking in early adulthood. Here, we leverage this temporal patterning to search for common gene ... Full text Link to item Cite

Normative Irritability in Youth: Developmental Findings From the Great Smoky Mountains Study.

Journal Article J Am Acad Child Adolesc Psychiatry · August 2015 OBJECTIVE: The goal of this study is to examine the developmental epidemiology of normative irritability and its tonic and phasic components in a longitudinal community sample of youth. METHOD: Eight waves of data from the prospective, community Great Smok ... Full text Link to item Cite

Childhood somatic complaints predict generalized anxiety and depressive disorders during young adulthood in a community sample.

Journal Article Psychol Med · June 2015 BACKGROUND: Children with somatic complaints are at increased risk for emotional disorders during childhood. Whether this elevated risk extends into young adulthood - and to which specific disorders - has rarely been tested with long-term prospective-longi ... Full text Link to item Cite

Adult mental health consequences of peer bullying and maltreatment in childhood: two cohorts in two countries.

Journal Article Lancet Psychiatry · June 2015 BACKGROUND: The adult mental health consequences of childhood maltreatment are well documented. Maltreatment by peers (ie, bullying) has also been shown to have long-term adverse effects. We aimed to determine whether these effects are just due to being ex ... Full text Link to item Cite

A heavy burden on young minds: the global burden of mental and substance use disorders in children and youth.

Journal Article Psychol Med · May 2015 BACKGROUND: Mental and substance use disorders are common and often persistent, with many emerging in early life. Compared to adult mental and substance use disorders, the global burden attributable to these disorders in children and youth has received rel ... Full text Link to item Cite

A genetically informed study of the longitudinal relation between irritability and anxious/depressed symptoms.

Journal Article J Am Acad Child Adolesc Psychiatry · May 2015 OBJECTIVE: Little is known about the longitudinal genetic and environmental association between juvenile irritability and symptoms of anxiety and depression. This study's goal was to assess the relationship between these constructs across a critical develo ... Full text Link to item Cite

Increase in untreated cases of psychiatric disorders during the transition to adulthood.

Journal Article Psychiatr Serv · April 1, 2015 OBJECTIVE: During the transition to adulthood, youths face challenges that may limit their likelihood of obtaining services for psychiatric problems. The goal of this analysis was to estimate changes in rates of service use and untreated psychiatric disord ... Full text Link to item Cite

Preschool anxiety disorders predict different patterns of amygdala-prefrontal connectivity at school-age.

Journal Article PLoS One · 2015 OBJECTIVE: In this prospective, longitudinal study of young children, we examined whether a history of preschool generalized anxiety, separation anxiety, and/or social phobia is associated with amygdala-prefrontal dysregulation at school-age. As an explora ... Full text Open Access Link to item Cite

Are children and adolescents with food allergies at increased risk for psychopathology?

Journal Article J Psychosom Res · December 2014 OBJECTIVE: Living with food allergy is a unique and potentially life-threatening stressor that requires constant vigilance to food-related stimuli, but little is known about whether adolescents with food allergies are at increased risk for psychopathology- ... Full text Link to item Cite

Adult diagnostic and functional outcomes of DSM-5 disruptive mood dysregulation disorder.

Journal Article Am J Psychiatry · June 2014 OBJECTIVE: Disruptive mood dysregulation disorder (DMDD) is a new disorder for DSM-5 that is uncommon and frequently co-occurs with other psychiatric disorders. Here, the authors test whether meeting diagnostic criteria for this disorder in childhood predi ... Full text Link to item Cite

Childhood bullying involvement predicts low-grade systemic inflammation into adulthood.

Journal Article Proc Natl Acad Sci U S A · May 27, 2014 Bullying is a common childhood experience that involves repeated mistreatment to improve or maintain one's status. Victims display long-term social, psychological, and health consequences, whereas bullies display minimal ill effects. The aim of this study ... Full text Open Access Link to item Cite

Sleep problems predict and are predicted by generalized anxiety/depression and oppositional defiant disorder.

Journal Article J Am Acad Child Adolesc Psychiatry · May 2014 OBJECTIVE: We tested whether sleep problems co-occur with, precede, and/or follow common psychiatric disorders during childhood and adolescence. We also clarified the role of comorbidity and tested for specificity of associations among sleep problems and p ... Full text Link to item Cite

Perceived family impact of preschool anxiety disorders.

Journal Article J Am Acad Child Adolesc Psychiatry · April 2014 OBJECTIVE: We examined the perceived impact of child anxiety disorders on family functioning, because such impact is a key predictor of mental health service receipt. In addition, we examined the relative impact of preschool anxiety compared to that of oth ... Full text Link to item Cite

Longitudinal patterns of anxiety from childhood to adulthood: the Great Smoky Mountains Study.

Journal Article J Am Acad Child Adolesc Psychiatry · January 2014 OBJECTIVE: The aims of this study were 2-fold: to provide a brief introduction to the prospective longitudinal Great Smoky Mountains Study and review recent findings; and to use this sample to conduct an epidemiologic analysis of common childhood anxiety d ... Full text Link to item Cite

Preschool anxiety disorders in pediatric primary care: prevalence and comorbidity.

Journal Article J Am Acad Child Adolesc Psychiatry · December 2013 OBJECTIVE: We sought to establish prevalence rates and detail patterns of comorbidity for generalized anxiety disorder, separation anxiety disorder, and social phobia in preschool-aged children. METHOD: The Duke Preschool Anxiety Study, a screen-stratified ... Full text Link to item Cite

C-reactive protein and substance use disorders in adolescence and early adulthood: a prospective analysis.

Journal Article Drug Alcohol Depend · December 1, 2013 BACKGROUND: Dysregulated immune function and elevated inflammation markers are seen in adults with chronic diseases, including some psychiatric disorders, but evidence on inflammation in the case of drug abuse is conflicting. OBJECTIVE: To test the concurr ... Full text Link to item Cite

Children with both asthma and depression are at risk for heightened inflammation.

Journal Article J Pediatr · November 2013 OBJECTIVE: To test whether children and adolescents with co-occurring asthma and depression are at risk for elevated inflammation-concurrently and at the next assessment. STUDY DESIGN: Up to 6 yearly assessments per person from the prospective, population- ... Full text Link to item Cite

Sex-differentiated changes in C-reactive protein from ages 9 to 21: the contributions of BMI and physical/sexual maturation.

Journal Article Psychoneuroendocrinology · October 2013 BACKGROUND: Sex differences in levels of C-reactive protein (CRP) are well established in adulthood, but little is known about when and why they emerge. Here, we tested longitudinal models of CRP levels from ages 9 to 21, when marked physical and behaviora ... Full text Link to item Cite

Impact of bullying in childhood on adult health, wealth, crime, and social outcomes.

Journal Article Psychol Sci · October 2013 Bullying is a serious problem for schools, parents, and public-policymakers alike. Bullying creates risks of health and social problems in childhood, but it is unclear if such risks extend into adulthood. A large cohort of children was assessed for bullyin ... Full text Link to item Cite

Irritable mood as a symptom of depression in youth: prevalence, developmental, and clinical correlates in the Great Smoky Mountains Study.

Journal Article J Am Acad Child Adolesc Psychiatry · August 2013 OBJECTIVE: DSM-IV grants episodic irritability an equal status to low mood as a cardinal criterion for the diagnosis of depression in youth, yet not in adults; however, evidence for irritability as a major criterion of depression in youth is lacking. This ... Full text Link to item Cite

Diagnostic transitions from childhood to adolescence to early adulthood.

Journal Article J Child Psychol Psychiatry · July 2013 BACKGROUND: Quantifying diagnostic transitions across development is needed to estimate the long-term burden of mental illness. This study estimated patterns of diagnostic transitions from childhood to adolescence and from adolescence to early adulthood. M ... Full text Link to item Cite

High quality methylome-wide investigations through next-generation sequencing of DNA from a single archived dry blood spot.

Journal Article Epigenetics · May 2013 The potential importance of DNA methylation in the etiology of complex diseases has led to interest in the development of methylome-wide association studies (MWAS) aimed at interrogating all methylation sites in the human genome. When using blood as biomat ... Full text Link to item Cite

Genes, environments, and developmental research: methods for a multi-site study of early substance abuse.

Journal Article Twin Res Hum Genet · April 2013 The importance of including developmental and environmental measures in genetic studies of human pathology is widely acknowledged, but few empirical studies have been published. Barriers include the need for longitudinal studies that cover relevant develop ... Full text Link to item Cite

Young Adult Obesity and Household Income: Effects of Unconditional Cash Transfers.

Journal Article Am Econ J Appl Econ · April 1, 2013 We investigate the effect of household cash transfers during childhood on young adult body mass indexes (BMI). The effects of extra income differ depending on the household's initial socioeconomic status (SES). Children from the initially poorest household ... Full text Link to item Cite

Adult psychiatric outcomes of bullying and being bullied by peers in childhood and adolescence.

Journal Article JAMA Psychiatry · April 2013 IMPORTANCE: Both bullies and victims of bullying are at risk for psychiatric problems in childhood, but it is unclear if this elevated risk extends into early adulthood. OBJECTIVE: To test whether bullying and/or being bullied in childhood predicts psychia ... Full text Link to item Cite

Dmdd likely atypical after early childhood

Journal Article Pediatric Annals · March 1, 2013 Cite

Prevalence, comorbidity, and correlates of DSM-5 proposed disruptive mood dysregulation disorder.

Journal Article Am J Psychiatry · February 2013 OBJECTIVE: No empirical studies on the DSM-5 proposed disruptive mood dysregulation disorder have yet been published. This study estimated prevalence, comorbidity, and correlates of this proposed disorder in the community. METHOD: Prevalence rates were est ... Full text Link to item Cite

Separating the domains of oppositional behavior: comparing latent models of the conners' oppositional subscale.

Journal Article J Am Acad Child Adolesc Psychiatry · February 2013 OBJECTIVE: Although oppositional defiant disorder (ODD) is usually considered the mildest of the disruptive behavior disorders, it is a key factor in predicting young adult anxiety and depression and is distinguishable from normal childhood behavior. In an ... Full text Link to item Cite

Indirect comorbidity in childhood and adolescence.

Journal Article Front Psychiatry · 2013 OBJECTIVE: Comorbidity between psychiatric disorders is common, but pairwise associations between two disorders may be explained by the presence of other diagnoses that are associated with both disorders or "indirect" comorbidity. MATERIALS AND METHODS: Co ... Full text Link to item Cite

Generalized anxiety and C-reactive protein levels: a prospective, longitudinal analysis.

Journal Article Psychol Med · December 2012 BACKGROUND: Generalized anxiety disorder (GAD) is highly co-morbid with depression. Depression is associated with elevated levels of the inflammation marker C-reactive protein (CRP), cross-sectionally and over time. To date, no studies have looked at the a ... Full text Link to item Cite

Predicting persistent alcohol problems: a prospective analysis from the Great Smoky Mountain Study.

Journal Article Psychol Med · September 2012 BACKGROUND: Rates of alcohol disorders peak in late adolescence and decrease substantially into the mid-20s. Our aim was to identify risk factors that predict alcohol problems that persist into the mid-20s. METHOD: Data are from the prospective, population ... Full text Link to item Cite

Psychiatric diagnostic interviews for children and adolescents: a comparative study.

Journal Article J Am Acad Child Adolesc Psychiatry · May 2012 OBJECTIVE: To compare examples of three styles of psychiatric interviews for youth: the Diagnostic Interview Schedule for Children (DISC) ("respondent-based"), the Child and Adolescent Psychiatric Assessment (CAPA) ("interviewer-based"), and the Developmen ... Full text Link to item Cite

Familial influence and childhood trauma in female alcoholism.

Journal Article Psychol Med · February 2012 BACKGROUND: To assess the role of genetic and environmental factors in female alcoholism using a large population-based twin sample, taking into account possible differences between early and late onset disease subtype. METHOD: Twins aged 20-47 years from ... Full text Link to item Cite

Relative impact of maternal depression and associated risk factors on offspring psychopathology.

Journal Article Br J Psychiatry · February 2012 BACKGROUND: In general, mothers with depression experience more environmental and family risk factors, and lead riskier lifestyles, than mothers who are not depressed. AIMS: To test whether the exposure of a child to risk factors associated with mental hea ... Full text Link to item Cite

Cumulative depression episodes predict later C-reactive protein levels: a prospective analysis.

Journal Article Biol Psychiatry · January 1, 2012 BACKGROUND: Depression is associated with elevated levels of the inflammation marker C-reactive protein (CRP); yet, the direction of this association remains unclear. This study tested bi-directional longitudinal associations between CRP and depression in ... Full text Link to item Cite

Child-, adolescent- and young adult-onset depressions: differential risk factors in development?

Journal Article Psychol Med · November 2011 BACKGROUND: Previous research reported that childhood adversity predicts juvenile- onset but not adult-onset depression, but studies confounded potentially genuine differences in adversity with differences in the recency with which adversity was experience ... Full text Link to item Cite

Trends in psychopathology across the adolescent years: what changes when children become adolescents, and when adolescents become adults?

Journal Article J Child Psychol Psychiatry · October 2011 BACKGROUND: Little is known about changes in the prevalence of psychiatric disorders between childhood and adolescence, and adolescence and adulthood. METHODS: We reviewed papers reporting prevalence rates of psychiatric disorders separately for childhood, ... Full text Link to item Cite

Genetic moderators and psychiatric mediators of the link between sexual abuse and alcohol dependence.

Journal Article Drug Alcohol Depend · June 1, 2011 BACKGROUND/OBJECTIVE: This study used a case-control female sample to test psychiatric mediators and genetic moderators of the effect of sexual abuse on later alcohol dependence. The study also tested differences between alcohol dependent women with or wit ... Full text Link to item Cite

Child μ-opioid receptor gene variant influences parent-child relations.

Journal Article Neuropsychopharmacology · May 2011 Variation in the μ-opioid receptor gene has been associated with early social behavior in mice and rhesus macaques. The current study tested whether the functional OPRM1 A118G predicted various indices of social relations in children. The sample included 2 ... Full text Link to item Cite

Cumulative prevalence of psychiatric disorders by young adulthood: a prospective cohort analysis from the Great Smoky Mountains Study.

Journal Article J Am Acad Child Adolesc Psychiatry · March 2011 OBJECTIVE: No longitudinal studies beginning in childhood have estimated the cumulative prevalence of psychiatric illness from childhood into young adulthood. The objective of this study was to estimate the cumulative prevalence of psychiatric disorders by ... Full text Link to item Cite

The developmental epidemiology of anxiety disorders: Phenomenology, prevalence, and comorbidity

Chapter · January 1, 2011 In this chapter we review the prevalence and comorbidity of anxiety disorders in general, and where possible the specifics of separation anxiety disorder (SAD), generalized anxiety disorder (GAD), specific phobias, panic, social phobia, and panic disorder. ... Full text Cite

Developmental pathways in oppositional defiant disorder and conduct disorder.

Journal Article J Abnorm Psychol · November 2010 The Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV; American Psychiatric Association, 1994) specifies a developmental relationship between oppositional defiant disorder (ODD) and conduct disorder (CD). Evidence for this link is ... Full text Link to item Cite

Outcomes of early pubertal timing in young women: a prospective population-based study.

Journal Article Am J Psychiatry · October 2010 OBJECTIVE: Early pubertal timing in girls is associated with psychosocial problems throughout adolescence, but it is unclear whether these problems persist into young adulthood. The authors analyzed outcomes in adolescence and young adulthood in girls in a ... Full text Link to item Cite

Posttraumatic stress without trauma in children.

Journal Article Am J Psychiatry · September 2010 OBJECTIVE: It remains unclear to what degree children show signs of posttraumatic stress disorder (PTSD) after experiencing low-magnitude stressors, or stressors milder than those required for the DSM-IV extreme stressor criterion. METHOD: A representative ... Full text Link to item Cite

Longitudinal dimensionality of adolescent psychopathology: testing the differentiation hypothesis.

Journal Article J Child Psychol Psychiatry · August 2010 BACKGROUND: The differentiation hypothesis posits that the underlying liability distribution for psychopathology is of low dimensionality in young children, inflating diagnostic comorbidity rates, but increases in dimensionality with age as latent syndrome ... Full text Link to item Cite

Association of family income supplements in adolescence with development of psychiatric and substance use disorders in adulthood among an American Indian population.

Journal Article JAMA · May 19, 2010 CONTEXT: In a natural experiment in which some families received income supplements, prevalence of adolescent behavioral symptoms decreased significantly. These adolescents are now young adults. OBJECTIVE: To examine the effects of income supplements in ad ... Full text Link to item Cite

CRP and Depression: A Test of Alternative Hypotheses

Conference BIOLOGICAL PSYCHIATRY · May 1, 2010 Link to item Cite

Personality and inflammation: the protective effect of openness to experience.

Journal Article Ethn Dis · 2010 BACKGROUND: Prior research found reduced mortality in coronary heart patients with higher scores on the Openness to Experience domain and its facets. Decreased C-reactive protein level (CRP) levels may be one mechanism by which higher Openness to Experienc ... Link to item Cite

Parents' Incomes and Children's Outcomes: A Quasi-Experiment.

Journal Article Am Econ J Appl Econ · January 2010 We examine the role that an exogenous increase in household income due to a government transfer unrelated to household characteristics plays in children's long run outcomes. Children in affected households have higher levels of education in their young adu ... Full text Open Access Link to item Cite

Childhood and adolescent psychiatric disorders as predictors of young adult disorders.

Journal Article Arch Gen Psychiatry · July 2009 CONTEXT: Most adults with a psychiatric disorder first met diagnostic criteria during childhood and/or adolescence, yet specific homotypic and heterotypic patterns of prediction have not been firmly established. OBJECTIVE: To establish which childhood and ... Full text Link to item Cite

Lifecourse Priorities Among Appalachian Emerging Adults: Revisiting Wallace's Organization of Diversity.

Journal Article Ethos · June 2009 We examine how social demographics (gender, age, or race-ethnicity), census tract characteristics, and family environment during childhood relate to variability in the lifecourse priorities of 344 Cherokee and white youth during emerging adulthood (age 19- ... Full text Link to item Cite

Configurations of common childhood psychosocial risk factors.

Journal Article J Child Psychol Psychiatry · April 2009 BACKGROUND: Co-occurrence of psychosocial risk factors is commonplace, but little is known about psychiatrically-predictive configurations of psychosocial risk factors. METHODS: Latent class analysis (LCA) was applied to 17 putative psychosocial risk facto ... Full text Link to item Cite

Moving from ethnography to epidemiology: lessons learned in Appalachia.

Journal Article Ann Hum Biol · 2009 BACKGROUND: Anthropologists are beginning to translate insights from ethnography into tools for population studies that assess the role of culture in human behavior, biology, and health. AIM: We describe several lessons learned in the creation and administ ... Full text Link to item Cite

Cultural and community determinants of subjective social status among Cherokee and White youth.

Journal Article Ethn Health · September 2008 BACKGROUND: . Subjective social status (SSS) is associated with physical and mental health in diverse samples. However, community, cultural, and ethnic influences on SSS are poorly understood, especially among rural and American Indian populations. OBJECTI ... Full text Link to item Cite

Specificity of putative psychosocial risk factors for psychiatric disorders in children and adolescents.

Journal Article J Child Psychol Psychiatry · January 2008 BACKGROUND: Most psychosocial risk factors appear to have general rather than specific patterns of association with common childhood and adolescence disorders. However, previous research has typically failed to 1) control for comorbidity among disorders, 2 ... Full text Link to item Cite

Childhood psychiatric disorders and young adult crime: a prospective, population-based study.

Journal Article Am J Psychiatry · November 2007 OBJECTIVE: While psychopathology is common in criminal populations, knowing more about what kinds of psychiatric disorders precede criminal behavior could be helpful in delineating at-risk children. The authors determined rates of juvenile psychiatric diso ... Full text Link to item Cite

Traumatic events and posttraumatic stress in childhood.

Journal Article Arch Gen Psychiatry · May 2007 CONTEXT: Traumatic events are common and are related to psychiatric impairment in childhood. Little is known about the risk for posttraumatic stress disorder (PTSD) across different types of trauma exposure in children. OBJECTIVE: To examine the developmen ... Full text Link to item Cite

Childhood conduct problems and service costs: Understanding the expensive kids

Conference JOURNAL OF MENTAL HEALTH POLICY AND ECONOMICS · March 1, 2007 Link to item Cite

Service costs of caring for adolescents with mental illness in a rural community, 1993-2000.

Journal Article Am J Psychiatry · January 2007 OBJECTIVE: Costs of treating child psychiatric disorders fall on educational, primary care, juvenile justice, and social service agencies as well as on psychiatric services. The authors estimated multiagency mental health costs by integrating service unit ... Full text Link to item Cite

The Latent Class Structure of ADHD Is Stable Across Informants

Journal Article Twin Research and Human Genetics · August 1, 2006 Full text Cite

The latent class structure of ADHD is stable across informants.

Journal Article Twin Res Hum Genet · August 2006 Previous studies have looked at the structure of attention-deficit/hyperactivity disorder (ADHD) using latent class analysis (LCA) of Child Behavior Checklist (CBCL) or Diagnostic and Statistical Manual of Mental Disorders (DSM) symptom structure. These st ... Full text Link to item Cite

The genetic and environmental contributions to oppositional defiant behavior: a multi-informant twin study.

Journal Article J Am Acad Child Adolesc Psychiatry · September 2005 OBJECTIVE: To estimate the genetic and environmental contributions to oppositional defiant behavior (ODB) from mother, father, and teacher report using the Conners Revised Short Forms in a large twin sample. METHOD: ODB data were collected from 1,595 mothe ... Full text Link to item Cite

Associations between temperament and DSM-IV externalizing disorders in children and adolescents.

Journal Article J Dev Behav Pediatr · December 2004 This study investigated associations between child temperament and DSM-IV disorders in children. A total of 156 probands (97 boys, 59 girls; mean age = 10.78 years) and 154 randomly selected siblings were assessed using the Junior Temperament and Character ... Full text Link to item Cite

Screening for DSM-IV externalizing disorders with the Child Behavior Checklist: a receiver-operating characteristic analysis.

Journal Article J Child Psychol Psychiatry · October 2004 BACKGROUND: This study examines the diagnostic accuracy of the CBCL syndrome AS scales for predicting DSM-IV Attention Deficit-Hyperactivity Disorder (ADHD) and Oppositional Defiant Disorder with or without Conduct Disorder (ODD/CD). METHODS: The sample in ... Full text Link to item Cite

Multi-informant assessment of temperament in children with externalizing behavior problems.

Journal Article J Clin Child Adolesc Psychol · September 2004 We examined the criterion validity of parent and self-report versions of the Junior Temperament and Character Inventory (JTCI) in children with high levels of externalizing problems. The sample included 412 children (206 participants and 206 siblings) part ... Full text Link to item Cite

Genetic influences on childhood competencies: a twin study.

Journal Article J Am Acad Child Adolesc Psychiatry · March 2003 OBJECTIVE: To estimate genetic, environmental, and rater contrast influences on parental reports of Activities, Social, School, and Total Competence scales of the Child Behavior Checklist (CBCL). METHOD: Parents of 492 twin pairs aged 8-12 years completed ... Full text Link to item Cite