Fang-Fang Yin

Journal Article Z Med Phys · September 7, 2023 BACKGROUND: Dosimetric validation of single isocenter multi-target radiosurgery plans is difficult due to conditions of electronic disequilibrium and the simultaneous irradiation of multiple off-axis lesions dispersed throughout the volume. Here we report ... Full text Link to item Cite

A neural ordinary differential equation model for visualizing deep neural network behaviors in multi-parametric MRI-based glioma segmentation.

Conference Med Phys · August 2023 PURPOSE: To develop a neural ordinary differential equation (ODE) model for visualizing deep neural network behavior during multi-parametric MRI-based glioma segmentation as a method to enhance deep learning explainability. METHODS: By hypothesizing that d ... Full text Link to item Cite

Stereotactic Radiosurgery vs Conventional Radiotherapy for Localized Vertebral Metastases of the Spine: Phase 3 Results of NRG Oncology/RTOG 0631 Randomized Clinical Trial.

Journal Article JAMA Oncol · June 1, 2023 IMPORTANCE: Spine metastasis can be treated with high-dose radiation therapy with advanced delivery technology for long-term tumor and pain control. OBJECTIVE: To assess whether patient-reported pain relief was improved with stereotactic radiosurgery (SRS) ... Full text Link to item Cite

Uncertainties in the dosimetric heterogeneity correction and its potential effect on local control in lung SBRT.

Journal Article Biomed Phys Eng Express · March 7, 2023 Objective. Dose calculation in lung stereotactic body radiation therapy (SBRT) is challenging due to the low density of the lungs and small volumes. Here we assess uncertainties associated with tissue heterogeneities using different dose calculation algori ... Full text Link to item Cite

View-sharing for 4D magnetic resonance imaging with randomized projection-encoding enables improvements of respiratory motion imaging for treatment planning in abdominothoracic radiotherapy.

Journal Article Phys Imaging Radiat Oncol · January 2023 BACKGROUND AND PURPOSE: The accuracy and precision of radiation therapy are dependent on the characterization of organ-at-risk and target motion. This work aims to demonstrate a 4D magnetic resonance imaging (MRI) method for improving spatial and temporal ... Full text Link to item Cite

Quantification of lung function on CT images based on pulmonary radiomic filtering.

Journal Article Med Phys · November 2022 PURPOSE: To develop a radiomics filtering technique for characterizing spatial-encoded regional pulmonary ventilation information on lung computed tomography (CT). METHODS: The lung volume was segmented on 46 CT images, and a 3D sliding window kernel was i ... Full text Link to item Cite

Input feature design and its impact on the performance of deep learning models for predicting fluence maps in intensity-modulated radiation therapy.

Journal Article Phys Med Biol · October 21, 2022 Objective. Deep learning (DL) models for fluence map prediction (FMP) have great potential to reduce treatment planning time in intensity-modulated radiation therapy (IMRT) by avoiding the lengthy inverse optimization process. This study aims to improve th ... Full text Link to item Cite

Fast four-dimensional cone-beam computed tomography reconstruction using deformable convolutional networks.

Journal Article Med Phys · October 2022 BACKGROUND: Although four-dimensional cone-beam computed tomography (4D-CBCT) is valuable to provide onboard image guidance for radiotherapy of moving targets, it requires a long acquisition time to achieve sufficient image quality for target localization. ... Full text Link to item Cite

Radiomics: a primer on high-throughput image phenotyping.

Journal Article Abdom Radiol (NY) · September 2022 Radiomics is a high-throughput approach to image phenotyping. It uses computer algorithms to extract and analyze a large number of quantitative features from radiological images. These radiomic features collectively describe unique patterns that can serve ... Full text Link to item Cite

Improving liver tumor image contrast and synthesizing novel tissue contrasts by adaptive multiparametric MRI fusion.

Journal Article Precis Radiat Oncol · September 2022 PURPOSE: Multiparametric MRI contains rich and complementary anatomical and functional information, which is often utilized separately. This study aims to propose an adaptive multiparametric MRI (mpMRI) fusion method and examine its capability in improving ... Full text Link to item Cite

Impact of image quality on radiomics applications.

Journal Article Phys Med Biol · July 22, 2022 Radiomics features extracted from medical images have been widely reported to be useful in the patient specific outcome modeling for variety of assessment and prediction purposes. Successful application of radiomics features as imaging biomarkers, however, ... Full text Link to item Cite

Patient-specific synthetic magnetic resonance imaging generation from cone beam computed tomography for image guidance in liver stereotactic body radiation therapy.

Journal Article Precis Radiat Oncol · June 2022 OBJECTIVE: Despite its prevalence, cone beam computed tomography (CBCT) has poor soft-tissue contrast, making it challenging to localize liver tumors. We propose a patient-specific deep learning model to generate synthetic magnetic resonance imaging (MRI) ... Full text Link to item Cite

A geometry-guided multi-beamlet deep learning technique for CT reconstruction.

Journal Article Biomed Phys Eng Express · May 13, 2022 Purpose. Previous studies have proposed deep-learning techniques to reconstruct CT images from sinograms. However, these techniques employ large fully-connected (FC) layers for projection-to-image domain transformation, producing large models requiring sub ... Full text Link to item Cite

A radiomics-boosted deep-learning model for COVID-19 and non-COVID-19 pneumonia classification using chest x-ray images.

Conference Med Phys · May 2022 PURPOSE: To develop a deep learning model design that integrates radiomics analysis for enhanced performance of COVID-19 and non-COVID-19 pneumonia detection using chest x-ray images. METHODS: As a novel radiomics approach, a 2D sliding kernel was implemen ... Full text Link to item Cite

Patient-specific deep learning model to enhance 4D-CBCT image for radiomics analysis.

Journal Article Phys Med Biol · April 1, 2022 Objective.4D-CBCT provides phase-resolved images valuable for radiomics analysis for outcome prediction throughout treatment courses. However, 4D-CBCT suffers from streak artifacts caused by under-sampling, which severely degrades the accuracy of radiomic ... Full text Link to item Cite

Enhancement of 4-D Cone-Beam Computed Tomography (4D-CBCT) Using a Dual-Encoder Convolutional Neural Network (DeCNN).

Journal Article IEEE Trans Radiat Plasma Med Sci · February 2022 4D-CBCT is a powerful tool to provide respiration-resolved images for the moving target localization. However, projections in each respiratory phase are intrinsically under-sampled under the clinical scanning time and imaging dose constraints. Images recon ... Full text Link to item Cite

The Effect of Various Dose Normalization Strategies When Implementing Linear Boltzmann Transport Equation Dose Calculation for Lung Stereotactic Body Radiation Therapy Planning.

Journal Article Pract Radiat Oncol · 2022 PURPOSE: To explore implications of various plan normalizations when implementing a linear Boltzmann transport equation solver dose calculation algorithm (LBTE) for lung stereotactic body radiation therapy (SBRT). METHODS AND MATERIALS: Eighty-seven plans ... Full text Link to item Cite

Evaluation of two automated treatment planning techniques for multiple brain metastases using a single isocenter.

Journal Article J Radiosurg SBRT · 2022 Two automated treatment planning techniques were evaluated for multiple brain metastases using a single isocenter. One technique is knowledge-based planning (KBP) using a stereotactic radiosurgery (SRS) model in Eclipse treatment planning system (TPS); and ... Link to item Cite

Post-Radiotherapy PET Image Outcome Prediction by Deep Learning Under Biological Model Guidance: A Feasibility Study of Oropharyngeal Cancer Application.

Journal Article Front Oncol · 2022 PURPOSE: To develop a method of biologically guided deep learning for post-radiation 18FDG-PET image outcome prediction based on pre-radiation images and radiotherapy dose information. METHODS: Based on the classic reaction-diffusion mechanism, a novel bio ... Full text Link to item Cite

Dosimetric variation in preoperative partial breast radiosurgery assessed by deformable image registrations.

Journal Article J Radiosurg SBRT · 2022 OBJECTIVE: To assess dosimetric variation caused by breast deformation in breast radiosurgery based on deformable image registration. METHODS: This study included 30 patients who were treated in the prone position for preoperative partial breast radiosurge ... Link to item Cite

Generation, validation, and benchmarking of a commercial independent Monte Carlo calculation beam model for multi-target SRS.

A neural ordinary differential equation model for visualizing deep neural network behaviors in multi-parametric MRI-based glioma segmentation.

Stereotactic Radiosurgery vs Conventional Radiotherapy for Localized Vertebral Metastases of the Spine: Phase 3 Results of NRG Oncology/RTOG 0631 Randomized Clinical Trial.

Uncertainties in the dosimetric heterogeneity correction and its potential effect on local control in lung SBRT.

View-sharing for 4D magnetic resonance imaging with randomized projection-encoding enables improvements of respiratory motion imaging for treatment planning in abdominothoracic radiotherapy.

Quantification of lung function on CT images based on pulmonary radiomic filtering.

Input feature design and its impact on the performance of deep learning models for predicting fluence maps in intensity-modulated radiation therapy.

Fast four-dimensional cone-beam computed tomography reconstruction using deformable convolutional networks.

Radiomics: a primer on high-throughput image phenotyping.

Improving liver tumor image contrast and synthesizing novel tissue contrasts by adaptive multiparametric MRI fusion.

Impact of image quality on radiomics applications.

Patient-specific synthetic magnetic resonance imaging generation from cone beam computed tomography for image guidance in liver stereotactic body radiation therapy.

A geometry-guided multi-beamlet deep learning technique for CT reconstruction.

A radiomics-boosted deep-learning model for COVID-19 and non-COVID-19 pneumonia classification using chest x-ray images.

Patient-specific deep learning model to enhance 4D-CBCT image for radiomics analysis.

Enhancement of 4-D Cone-Beam Computed Tomography (4D-CBCT) Using a Dual-Encoder Convolutional Neural Network (DeCNN).

The Effect of Various Dose Normalization Strategies When Implementing Linear Boltzmann Transport Equation Dose Calculation for Lung Stereotactic Body Radiation Therapy Planning.

Evaluation of two automated treatment planning techniques for multiple brain metastases using a single isocenter.

Post-Radiotherapy PET Image Outcome Prediction by Deep Learning Under Biological Model Guidance: A Feasibility Study of Oropharyngeal Cancer Application.

Dosimetric variation in preoperative partial breast radiosurgery assessed by deformable image registrations.

Transfer learning for fluence map prediction in adrenal stereotactic body radiation therapy.

Conference Phys Med Biol · December 6, 2021 Objective:To design a deep transfer learning framework for modeling fluence map predictions for stereotactic body radiation therapy (SBRT) of adrenal cancer and similar sites that usually have a small number of cases.Approach:We developed a transfer learni ... Full text Link to item Cite

Prior image-guided cone-beam computed tomography augmentation from under-sampled projections using a convolutional neural network.

Journal Article Quant Imaging Med Surg · December 2021 BACKGROUND: Acquiring sparse-view cone-beam computed tomography (CBCT) is an effective way to reduce the imaging dose. However, images reconstructed by the conventional filtered back-projection method suffer from severe streak artifacts due to the projecti ... Full text Link to item Cite

Artificial intelligence applications in intensity modulated radiation treatment planning: an overview.

Journal Article Quant Imaging Med Surg · December 2021 Artificial intelligence (AI) refers to methods that improve and automate challenging human tasks by systematically capturing and applying relevant knowledge in these tasks. Over the past decades, a number of approaches have been developed to address differ ... Full text Link to item Cite

Multi-contrast four-dimensional magnetic resonance imaging (MC-4D-MRI): Development and initial evaluation in liver tumor patients.

Journal Article Med Phys · December 2021 PURPOSE: To develop a novel multi-contrast four-dimensional magnetic resonance imaging (MC-4D-MRI) technique that expands single image contrast 4D-MRI to a spectrum of native and synthetic image contrasts and to evaluate its feasibility in liver tumor pati ... Full text Link to item Cite

Assessing the robustness of artificial intelligence powered planning tools in radiotherapy clinical settings-a phantom simulation approach.

Journal Article Quant Imaging Med Surg · December 2021 BACKGROUND: Artificial intelligence (AI) based radiotherapy treatment planning tools have gained interest in automating the treatment planning process. It is essential to understand their overall robustness in various clinical scenarios. This is an existin ... Full text Link to item Cite

Insights of an AI agent via analysis of prediction errors: a case study of fluence map prediction for radiation therapy planning.

Journal Article Phys Med Biol · November 26, 2021 Purpose.We have previously reported an artificial intelligence (AI) agent that automatically generates intensity-modulated radiation therapy (IMRT) plans via fluence map prediction, by-passing inverse planning. This AI agent achieved clinically comparable ... Full text Link to item Cite

A Dosimetric Study Comparing Two Beam Arrangement Strategies in Fractionated Thoracic Spine Stereotactic Body Radiotherapy (SBRT) Planning.

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)To compare dosimetric results of two beam arrangement strategies and their robustness to setup uncertainties in fractionated thoracic spine Stereotactic Body Radiotherapy (SBRT) MATERIALS/METHODS: Fifteen patients who received ... Full text Cite

AAPM Task Group 198 Report: An implementation guide for TG 142 quality assurance of medical accelerators.

Journal Article Med Phys · October 2021 The charges on this task group (TG) were as follows: (a) provide specific procedural guidelines for performing the tests recommended in TG 142; (b) provide estimate of the range of time, appropriate personnel, and qualifications necessary to complete the t ... Full text Link to item Cite

A comparison of two methodologies for radiotherapy treatment plan optimization and QA for clinical trials.

Journal Article J Appl Clin Med Phys · October 2021 BACKGROUND AND PURPOSE: The efficacy of clinical trials and the outcome of patient treatment are dependent on the quality assurance (QA) of radiation therapy (RT) plans. There are two widely utilized approaches that include plan optimization guidance creat ... Full text Link to item Cite

A geometry-guided deep learning technique for CBCT reconstruction.

Journal Article Phys Med Biol · July 30, 2021 Purpose.Although deep learning (DL) technique has been successfully used for computed tomography (CT) reconstruction, its implementation on cone-beam CT (CBCT) reconstruction is extremely challenging due to memory limitations. In this study, a novel DL tec ... Full text Link to item Cite

Intrinsic radiomic expression patterns after 20 Gy demonstrate early metabolic response of oropharyngeal cancers.

Journal Article Med Phys · July 2021 PURPOSE: This study investigated the prognostic potential of intra-treatment PET radiomics data in patients undergoing definitive (chemo) radiation therapy for oropharyngeal cancer (OPC) on a prospective clinical trial. We hypothesized that the radiomic ex ... Full text Link to item Cite

An artificial intelligence-driven agent for real-time head-and-neck IMRT plan generation using conditional generative adversarial network (cGAN).

Journal Article Med Phys · June 2021 PURPOSE: To develop an artificial intelligence (AI) agent for fully automated rapid head-and-neck intensity-modulated radiation therapy (IMRT) plan generation without time-consuming dose-volume-based inverse planning. METHODS: This AI agent was trained via ... Full text Link to item Cite

A generative adversarial network (GAN)-based technique for synthesizing realistic respiratory motion in the extended cardiac-torso (XCAT) phantoms.

Journal Article Phys Med Biol · May 31, 2021 Objective. Synthesize realistic and controllable respiratory motions in the extended cardiac-torso (XCAT) phantoms by developing a generative adversarial network (GAN)-based deep learning technique.Methods. A motion generation model was developed using bic ... Full text Link to item Cite

Radiogenomic Analysis of Locally Advanced Lung Cancer Based on CT Imaging and Intratreatment Changes in Cell-Free DNA.

Journal Article Radiol Imaging Cancer · April 2021 The radiologic appearance of locally advanced lung cancer may be linked to molecular changes of the disease during treatment, but characteristics of this phenomenon are poorly understood. Radiomics, liquid biopsy of cell-free DNA (cfDNA), and next-generati ... Full text Link to item Cite

An Interpretable Planning Bot for Pancreas Stereotactic Body Radiation Therapy.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2021 PURPOSE: Pancreas stereotactic body radiation therapy (SBRT) treatment planning requires planners to make sequential, time-consuming interactions with the treatment planning system to reach the optimal dose distribution. We sought to develop a reinforcemen ... Full text Link to item Cite

4D radiomics: impact of 4D-CBCT image quality on radiomic analysis.

Journal Article Phys Med Biol · February 11, 2021 PURPOSE: To investigate the impact of 4D-CBCT image quality on radiomic analysis and the efficacy of using deep learning based image enhancement to improve the accuracy of radiomic features of 4D-CBCT. MATERIAL AND METHODS: In this study, 4D-CT data from 1 ... Full text Link to item Cite

Evaluation of eddy current distortion and field inhomogeneity distortion corrections in MR diffusion imaging using log-demons DIR method.

Journal Article Phys Med Biol · January 29, 2021 To investigate the feasibility of the log-demons deformable image registration (DIR) method to correct eddy current and field inhomogeneity distortions while preserving diffusion tensor information. Diffusion-weighted images (DWIs) are susceptible to disto ... Full text Link to item Cite

Enhancing digital tomosynthesis (DTS) for lung radiotherapy guidance using patient-specific deep learning model.

Journal Article Phys Med Biol · January 26, 2021 Digital tomosynthesis (DTS) has been proposed as a fast low-dose imaging technique for image-guided radiation therapy (IGRT). However, due to the limited scanning angle, DTS reconstructed by the conventional FDK method suffers from significant distortions ... Full text Link to item Cite

Slice-stacking T2-weighted MRI for fast determination of internal target volume for liver tumor.

Journal Article Quant Imaging Med Surg · January 2021 BACKGROUND: To investigate the feasibility of generating maximum intensity projection (MIP) images to determine internal target volume (ITV) using slice-stacking MRI (SS-MRI) technique. METHODS: Slice-stacking is a technique which applies a multi-slice MRI ... Full text Link to item Cite

Clinical Experience With Machine Learning-Based Automated Treatment Planning for Whole Breast Radiation Therapy.

Journal Article Adv Radiat Oncol · 2021 PURPOSE: The machine learning-based automated treatment planning (MLAP) tool has been developed and evaluated for breast radiation therapy planning at our institution. We implemented MLAP for patient treatment and assessed our clinical experience for its p ... Full text Open Access Link to item Cite

Deep Learning-Based Fluence Map Prediction for Pancreas Stereotactic Body Radiation Therapy With Simultaneous Integrated Boost.

Journal Article Adv Radiat Oncol · 2021 PURPOSE: Treatment planning for pancreas stereotactic body radiation therapy (SBRT) is a challenging task, especially with simultaneous integrated boost treatment approaches. We propose a deep learning (DL) framework to accurately predict fluence maps from ... Full text Link to item Cite

Radiomics and Outcome Prediction

Conference MEDICAL PHYSICS · 2021 Cite

Outcomes in Patients With 4 to 10 Brain Metastases Treated With Dose-Adapted Single-Isocenter Multitarget Stereotactic Radiosurgery: A Prospective Study.

Journal Article Adv Radiat Oncol · 2021 PURPOSE: To examine the effectiveness and safety of single-isocenter multitarget stereotactic radiosurgery using a volume-adapted dosing strategy in patients with 4 to 10 brain metastases. METHODS AND MATERIALS: Adult patients with 4 to 10 brain metastases ... Full text Link to item Cite

RETRACTED: An Encoder-Decoder Based Deep Learning AI agent for Spatial Dose Distribution Prediction: A Study of Complex Head-and-Neck IMRT Application

Conference International journal of radiation oncology, biology, physics · November 1, 2020 This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This abstract has been retracted at the request of the authors. After submitting this abstract the authors realized that th ... Full text Cite

RETRACTED: An Encoder-Decoder Based Deep Learning AI agent for Spatial Dose Distribution Prediction: A Study of Complex Head-and-Neck IMRT Application.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2020 This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This abstract has been retracted at the request of the authors. After submitting this abstract the authors realized that th ... Full text Link to item Cite

Automatic detection of pulmonary nodules on CT images with YOLOv3: development and evaluation using simulated and patient data.

Journal Article Quant Imaging Med Surg · October 2020 BACKGROUND: To develop a high-efficiency pulmonary nodule computer-aided detection (CAD) method for localization and diameter estimation. METHODS: The developed CAD method centralizes a novel convolutional neural network (CNN) algorithm, You Only Look Once ... Full text Link to item Cite

Automatic detection of pulmonary nodules on CT images with YOLOv3: development and evaluation using simulated and patient data

Journal Article Quantitative imaging in medicine and surgery · October 2020 Background To develop a high-efficiency pulmonary nodule computer-aided detection (CAD) method for localization and diameter estimation. Methods The developed CAD method centralizes a novel convolutional neural network (CNN) algorithm, You Only Look Once ( ... Cite

Adaptive respiratory signal prediction using dual multi-layer perceptron neural networks.

Journal Article Phys Med Biol · September 14, 2020 To improve the prediction accuracy of respiratory signals by adapting the multi-layer perceptron neural network (MLP-NN) model to changing respiratory signals. We have previously developed an MLP-NN to predict respiratory signals obtained from a real-time ... Full text Link to item Cite

Automatic IMRT planning via static field fluence prediction (AIP-SFFP): a deep learning algorithm for real-time prostate treatment planning.

Journal Article Phys Med Biol · September 8, 2020 The purpose of this work was to develop a deep learning (DL) based algorithm, Automatic intensity-modulated radiotherapy (IMRT) Planning via Static Field Fluence Prediction (AIP-SFFP), for automated prostate IMRT planning with real-time planning efficiency ... Full text Link to item Cite

Retrospective quality metrics review of stereotactic radiosurgery plans treating multiple targets using single-isocenter volumetric modulated arc therapy.

Journal Article J Appl Clin Med Phys · June 2020 PURPOSE: To characterize key plan quality metrics in multi-target stereotactic radiosurgery (SRS) plans treated using single-isocenter volumetric modulated arc therapy (VMAT) in comparison to dynamic conformal arc (DCA) plans treating single target. To inv ... Full text Link to item Cite

Knowledge-Based Tradeoff Hyperplanes for Head and Neck Treatment Planning.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2020 PURPOSE: To develop a tradeoff hyperplane model to facilitate tradeoff decision-making before inverse planning. METHODS AND MATERIALS: We propose a model-based approach to determine the tradeoff hyperplanes that allow physicians to navigate the clinically ... Full text Link to item Cite

Development of realistic multi-contrast textured XCAT (MT-XCAT) phantoms using a dual-discriminator conditional-generative adversarial network (D-CGAN).

Journal Article Phys Med Biol · March 19, 2020 Develop a machine learning-based method to generate multi-contrast anatomical textures in the 4D extended cardiac-torso (XCAT) phantom for more realistic imaging simulations. As a pilot study, we synthesize CT and CBCT textures in the chest region. For tra ... Full text Link to item Cite

Digital phantoms for characterizing inconsistencies among radiomics extraction toolboxes.

Journal Article Biomed Phys Eng Express · March 2, 2020 PURPOSE: to develop digital phantoms for characterizing inconsistencies among radiomics extraction methods based on three radiomics toolboxes: CERR (Computational Environment for Radiological Research), IBEX (imaging biomarker explorer), and an in-house ra ... Full text Link to item Cite

Motion robust 4D-MRI sorting based on anatomic feature matching: A digital phantom simulation study.

Journal Article Radiat Med Prot · March 2020 PURPOSE: Motion artifacts induced by breathing variations are common in 4D-MRI images. This study aims to reduce the motion artifacts by developing a novel, robust 4D-MRI sorting method based on anatomic feature matching and applicable in both cine and seq ... Full text Link to item Cite

Volumetric cine magnetic resonance imaging (VC-MRI) using motion modeling, free-form deformation and multi-slice undersampled 2D cine MRI reconstructed with spatio-temporal low-rank decomposition.

Journal Article Quant Imaging Med Surg · February 2020 BACKGROUND: The purpose of this study is to improve on-board volumetric cine magnetic resonance imaging (VC-MRI) using multi-slice undersampled cine images reconstructed using spatio-temporal k-space data, patient prior 4D-MRI, motion modeling (MM) and fre ... Full text Link to item Cite

A multi-scale framework with unsupervised joint training of convolutional neural networks for pulmonary deformable image registration.

Journal Article Phys Med Biol · January 13, 2020 To achieve accurate and fast deformable image registration (DIR) for pulmonary CT, we proposed a Multi-scale DIR framework with unsupervised Joint training of Convolutional Neural Network (MJ-CNN). MJ-CNN contains three models at multi-scale levels for a c ... Full text Link to item Cite

Dose-Distribution-Driven PET Image-Based Outcome Prediction (DDD-PIOP): A Deep Learning Study for Oropharyngeal Cancer IMRT Application

Conference Frontiers in oncology · January 2020 Purpose To develop a deep learning-based AI agent, DDD-PIOP (Dose-Distribution-Driven PET Image Outcome Prediction), for predicting 18FDG-PET image outcomes of oropharyngeal cancer (OPC) in response to intensity-modulated radiation therapy (IMRT). Methods ... Cite

Technical Note: Investigation of the dosimetric impact of stray radiation on the Common Control Unit of the IBA Blue Phantom2.

Journal Article J Appl Clin Med Phys · January 2020 PURPOSE: This technical note aims to investigate the dosimetric impact of stray radiation on the Common Control Unit (CCU) of the IBA Blue Phantom2 and the measured beam data. METHODS: Three CCUs of the same model were used for the study. The primary test ... Full text Link to item Cite

Accuracy and efficiency of image-guided radiation therapy (IGRT) for preoperative partial breast radiosurgery.

Journal Article J Radiosurg SBRT · 2020 OBJECTIVE: To analyze and evaluate accuracy and efficiency of IGRT process for preoperative partial breast radiosurgery. METHODS: Patients were initially setup with skin marks and 5 steps were performed: (1) Initial orthogonal 2D kV images, (2) pre-treatme ... Open Access Link to item Cite

Dose-Distribution-Driven PET Image-Based Outcome Prediction (DDD-PIOP): A Deep Learning Study for Oropharyngeal Cancer IMRT Application.

Journal Article Front Oncol · 2020 PURPOSE: To develop a deep learning-based AI agent, DDD-PIOP (Dose-Distribution-Driven PET Image Outcome Prediction), for predicting 18FDG-PET image outcomes of oropharyngeal cancer (OPC) in response to intensity-modulated radiation therapy (IMRT). METHODS ... Full text Open Access Link to item Cite

NRG Oncology Survey on Practice and Technology Use in SRT and SBRT Delivery.

Journal Article Front Oncol · 2020 PURPOSE: To assess stereotactic radiotherapy (SRT)/stereotactic body radiotherapy (SBRT) practices by polling clinics participating in multi-institutional clinical trials. METHODS: The NRG Oncology Medical Physics Subcommittee distributed a survey consisti ... Full text Open Access Link to item Cite

Knowledge Models as Teaching Aid for Training Intensity Modulated Radiation Therapy Planning: A Lung Cancer Case Study.

Journal Article Front Artif Intell · 2020 Purpose: Artificial intelligence (AI) employs knowledge models that often behave as a black-box to the majority of users and are not designed to improve the skill level of users. In this study, we aim to demonstrate the feasibility that AI can serve as an ... Full text Link to item Cite

Fluence Map Prediction Using Deep Learning Models - Direct Plan Generation for Pancreas Stereotactic Body Radiation Therapy.

Journal Article Front Artif Intell · 2020 Purpose: Treatment planning for pancreas stereotactic body radiation therapy (SBRT) is a difficult and time-consuming task. In this study, we aim to develop a novel deep learning framework to generate clinical-quality plans by direct prediction of fluence ... Full text Open Access Link to item Cite

Advances of Radiomics and Genomics in Cancer Management

Conference MEDICAL PHYSICS · 2020 Cite

Augmentation of CBCT Reconstructed From Under-Sampled Projections Using Deep Learning.

Journal Article IEEE Trans Med Imaging · November 2019 Edges tend to be over-smoothed in total variation (TV) regularized under-sampled images. In this paper, symmetric residual convolutional neural network (SR-CNN), a deep learning based model, was proposed to enhance the sharpness of edges and detailed anato ... Full text Link to item Cite

Liver 4D-MRI: An Image Mutual Information based Retrospective Self-sorting Method

Conference 2019 International Conference on Medical Imaging Physics and Engineering, ICMIPE 2019 · November 1, 2019 Four-dimensional MRI (4D-MRI) is an emerging technique for soft-tissue motion management in radiotherapy treatment planning. The purpose of this study was to develop a novel image mutual information (MI) based retrospective 4DMRI sorting method that is ful ... Full text Cite

Task Group 174 Report: Utilization of [18 F]Fluorodeoxyglucose Positron Emission Tomography ([18 F]FDG-PET) in Radiation Therapy.

Journal Article Med Phys · October 2019 The use of positron emission tomography (PET) in radiation therapy (RT) is rapidly increasing in the areas of staging, segmentation, treatment planning, and response assessment. The most common radiotracer is 18 F-fluorodeoxyglucose ([18 F]FDG), a glucose ... Full text Open Access Link to item Cite

Daily edge deformation prediction using an unsupervised convolutional neural network model for low dose prior contour based total variation CBCT reconstruction (PCTV-CNN).

Journal Article Biomed Phys Eng Express · October 2019 PURPOSE: Previously we developed a PCTV method to enhance the edge sharpness for low-dose CBCT reconstruction. However, the iterative deformable registration method used for deforming edges from planning-CT to on-board CBCT is time-consuming and user-depen ... Full text Link to item Cite

Modeling of multiple planning target volumes for head and neck treatments in knowledge-based treatment planning.

Journal Article Med Phys · September 2019 PURPOSE: The purpose of this study is to develop an accurate and reliable dose volume histogram (DVH) prediction method for external beam radiation therapy plans with multiple planning target volumes (PTVs). MATERIALS AND METHODS: We present a novel DVH pr ... Full text Link to item Cite

LINAC based stereotactic radiosurgery for multiple brain metastases: guidance for clinical implementation.

Journal Article Acta Oncol · September 2019 Introduction: Stereotactic radiosurgery (SRS) is a promising treatment option for patients with multiple brain metastases (BM). Recent technical advances have made LINAC based SRS a patient friendly technique, allowing for accurate patient positioning and ... Full text Link to item Cite

Feasibility of radiosurgery dosimetry using NIPAM 3D dosimeters and x-ray CT

Conference Journal of Physics: Conference Series · August 29, 2019 We investigated the feasibility of using N-isopropylacrylamide (NIPAM) dosimeters with x-ray CT to verify radiosurgery dose. Dosimeters were prepared at one facility and shipped to a second facility for irradiation. A simulation CT was acquired and plans p ... Full text Cite

Predicting real-time 3D deformation field maps (DFM) based on volumetric cine MRI (VC-MRI) and artificial neural networks for on-board 4D target tracking: a feasibility study.

Journal Article Phys Med Biol · August 21, 2019 To predict real-time 3D deformation field maps (DFMs) using Volumetric Cine MRI (VC-MRI) and adaptive boosting and multi-layer perceptron neural network (ADMLP-NN) for 4D target tracking. One phase of a prior 4D-MRI is set as the prior phase, MRIprior. Pri ... Full text Link to item Cite

An Exploratory Radiomics Approach to Quantifying Pulmonary Function in CT Images.

Journal Article Sci Rep · August 8, 2019 Contemporary medical imaging is becoming increasingly more quantitative. The emerging field of radiomics is a leading example. By translating unstructured data (i.e., images) into structured data (i.e., imaging features), radiomics can potentially characte ... Full text Open Access Link to item Cite

Low dose cone-beam computed tomography reconstruction via hybrid prior contour based total variation regularization (hybrid-PCTV).

Journal Article Quant Imaging Med Surg · July 2019 BACKGROUND: Previously, we developed a prior contour based total variation (PCTV) method to use edge information derived from prior images for edge enhancement in low-dose cone-beam computed tomography (CBCT) reconstruction. However, the accuracy of edge e ... Full text Link to item Cite

A robust deformable image registration enhancement method based on radial basis function.

Journal Article Quant Imaging Med Surg · July 2019 BACKGROUND: To develop and evaluate a robust deformable image registration (DIR) enhancement method based on radial basis function (RBF) expansion. METHODS: To improve DIR accuracy using sparsely available measured displacements, it is crucial to estimate ... Full text Open Access Link to item Cite

Probability-based 3D k-space sorting for motion robust 4D-MRI.

Journal Article Quant Imaging Med Surg · July 2019 BACKGROUND: Current 4D-MRI techniques are prone to breathing-variation-induced motion artifacts. This study developed a novel method for motion-robust multi-cycle 4D-MRI using probability-based multi-cycle sorting to overcome this deficiency. METHODS: The ... Full text Link to item Cite

A hybrid proton and hyperpolarized gas tagging MRI technique for lung respiratory motion imaging: a feasibility study.

Journal Article Phys Med Biol · May 16, 2019 The aim of this work was to develop a novel hybrid 3D hyperpolarized (HP) gas tagging MRI (t-MRI) technique and to evaluate it for lung respiratory motion measurement with comparison to deformable image registrations (DIR) methods. Three healthy subjects u ... Full text Link to item Cite

First clinical retrospective investigation of limited projection CBCT for lung tumor localization in patients receiving SBRT treatment.

Journal Article Phys Med Biol · May 8, 2019 To clinically investigate the limited-projection CBCT (LP-CBCT) technology for daily positioning of patients receiving breath-hold lung SBRT radiation treatment and to investigate the feasibility of reconstructing fast 4D-CBCT from 1 min 3D-CBCT scan. Elev ... Full text Link to item Cite

Genetic Single Neuron Anatomy Reveals Fine Granularity of Cortical Axo-Axonic Cells.

Journal Article Cell Rep · March 12, 2019 Parsing diverse nerve cells into biological types is necessary for understanding neural circuit organization. Morphology is an intuitive criterion for neuronal classification and a proxy of connectivity, but morphological diversity and variability often pr ... Full text Link to item Cite

A Spatiotemporal-Constrained Sorting Method for Motion-Robust 4D-MRI: A Feasibility Study.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2019 PURPOSE: To develop a spatiotemporal-constrained sorting technique for motion-robust 4 dimensional-magnetic resonance imaging. METHODS AND MATERIALS: This sorting method implemented 2 new approaches for 4-dimensional imaging: (1) an optimized sparse k-spac ... Full text Link to item Cite

Evaluation of dosimetric uncertainty caused by MR geometric distortion in MRI-based liver SBRT treatment planning.

Journal Article J Appl Clin Med Phys · February 2019 PURPOSE: MRI-based treatment planning is a promising technique for liver stereotactic-body radiation therapy (SBRT) treatment planning to improve target volume delineation and reduce radiation dose to normal tissues. MR geometric distortion, however, is a ... Full text Open Access Link to item Cite

Association of pre-treatment radiomic features with lung cancer recurrence following stereotactic body radiation therapy.

Journal Article Phys Med Biol · January 8, 2019 The purpose of this work was to investigate the potential relationship between radiomic features extracted from pre-treatment x-ray CT images and clinical outcomes following stereotactic body radiation therapy (SBRT) for non-small-cell lung cancer (NSCLC). ... Full text Open Access Link to item Cite

Incorporating Case-Based Reasoning for Radiation Therapy Knowledge Modeling: A Pelvic Case Study

Conference Technology in Cancer Research and Treatment · January 1, 2019 Knowledge models in radiotherapy capture the relation between patient anatomy and dosimetry to provide treatment planning guidance. When treatment schemes evolve, existing models struggle to predict accurately. We propose a case-based reasoning framework d ... Full text Cite

The effect of setup uncertainty on optimal dosimetric margin in LINAC-based stereotactic radiosurgery with dynamic conformal arc technique.

Journal Article J Radiosurg SBRT · 2019 PURPOSE: To estimate the combined effect of setup uncertainty on optimal dosimetric margin by analyzing the dose distribution and biological effect in LINAC-based stereotactic radiosurgery (SRS) with dynamic conformal arc (DCA) technique. METHODS: SRS trea ... Link to item Cite

Impact of Esophageal Motion on Dosimetry and Toxicity With Thoracic Radiation Therapy.

Journal Article Technol Cancer Res Treat · 2019 PURPOSE: To investigate the impact of intra- and inter-fractional esophageal motion on dosimetry and observed toxicity in a phase I dose escalation study of accelerated radiotherapy with concurrent chemotherapy for locally advanced lung cancer. METHODS AND ... Full text Open Access Link to item Cite

Data clustering based on Langevin annealing with a self-consistent potential

Journal Article Quarterly of Applied Mathematics · January 1, 2019 This paper introduces a novel data clustering algorithm based on Langevin dynamics, where the associated potential is constructed directly from the data. To introduce a self-consistent potential, we adopt the potential model from the established Quantum Cl ... Full text Open Access Cite

Knowledge-Based Statistical Inference Method for Plan Quality Quantification.

Journal Article Technol Cancer Res Treat · January 1, 2019 AIM: The aim of the study is to develop a geometrically adaptive and statistically robust plan quality inference method. METHODS AND MATERIALS: We propose a knowledge-based plan quality inference method that references to similar plans in the historical da ... Full text Open Access Link to item Cite

Goal-Driven Beam Setting Optimization for Whole-Breast Radiation Therapy.

Journal Article Technol Cancer Res Treat · January 1, 2019 PURPOSE: To develop an automated optimization program to generate optimal beam settings for whole-breast radiation therapy driven by clinically oriented goals. MATERIALS AND METHODS: Forty patients were retrospectively included in this study. Each patient' ... Full text Open Access Link to item Cite

Investigation of calibration-based projection domain dual energy decomposition CBCT technique for brain radiotherapy applications

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2019 The purpose of the present study was to develop and evaluate a practical dual-energy imaging approach for enhancing on-board cone-beam CT (CBCT) image quality for brain radiotherapy applications. The proposed primary technique involves a projection domain ... Full text Cite

Automatic Planning of Whole Breast Radiation Therapy Using Machine Learning Models.

Journal Article Front Oncol · 2019 Purpose: To develop an automatic treatment planning system for whole breast radiation therapy (WBRT) based on two intensity-modulated tangential fields, enabling near-real-time planning. Methods and Materials: A total of 40 WBRT plans from a single institu ... Full text Open Access Link to item Cite

Incorporating Case-Based Reasoning for Radiation Therapy Knowledge Modeling: A Pelvic Case Study.

Journal Article Technol Cancer Res Treat · January 1, 2019 Knowledge models in radiotherapy capture the relation between patient anatomy and dosimetry to provide treatment planning guidance. When treatment schemes evolve, existing models struggle to predict accurately. We propose a case-based reasoning framework d ... Full text Open Access Link to item Cite

The effect of MLC leaf width in single-isocenter multi-target radiosurgery with volumetric modulated arc therapy.

Journal Article J Radiosurg SBRT · 2019 PURPOSE: Single-isocenter multi-target (SIMT) volumetric modulated arc therapy (VMAT) is primarily limited to linear accelerators utilizing 2.5 mm leaf width MLCs. We explore feasibility of applying this technique to linear accelerators utilizing MLCs with ... Open Access Link to item Cite

An investigation of machine learning methods in delta-radiomics feature analysis.

Journal Article PLoS One · 2019 PURPOSE: This study aimed to investigate the effectiveness of using delta-radiomics to predict overall survival (OS) for patients with recurrent malignant gliomas treated by concurrent stereotactic radiosurgery and bevacizumab, and to investigate the effec ... Full text Open Access Link to item Cite

An initial investigation of hyperpolarized gas tagging magnetic resonance imaging in evaluating deformable image registration-based lung ventilation.

Journal Article Med Phys · December 2018 BACKGROUND: Deformable image registration (DIR)-based lung ventilation mapping is attractive due to its simplicity, and also challenging due to its susceptibility to errors and uncertainties. In this study, we explored the use of 3D Hyperpolarized (HP) gas ... Full text Link to item Cite

Association of Interim FDG-PET Imaging During Chemoradiation for Squamous Anal Canal Carcinoma With Recurrence.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2018 PURPOSE: Imaging parameters from 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) before and after chemoradiation therapy (CRT) for anal canal cancer correlate with clinical outcomes. This prospective, hypothesis-generating pilot study inv ... Full text Link to item Cite

Spatial-temporal variability of radiomic features and its effect on the classification of lung cancer histology.

Journal Article Phys Med Biol · November 8, 2018 The purpose of this research was to study the sensitivity of Computed Tomography (CT) radiomic features to motion blurring and signal-to-noise ratios (SNR), and investigate its downstream effect regarding the classification of non-small cell lung cancer (N ... Full text Open Access Link to item Cite

Effect of machine learning methods on predicting NSCLC overall survival time based on Radiomics analysis.

Journal Article Radiat Oncol · October 5, 2018 BACKGROUND: To investigate the effect of machine learning methods on predicting the Overall Survival (OS) for non-small cell lung cancer based on radiomics features analysis. METHODS: A total of 339 radiomic features were extracted from the segmented tumor ... Full text Open Access Link to item Cite

Lung IMRT planning with automatic determination of beam angle configurations.

Journal Article Phys Med Biol · July 6, 2018 Beam angle configuration is a major planning decision in intensity modulated radiation treatment (IMRT) that has a significant impact on dose distributions and thus quality of treatment, especially in complex planning cases such as those for lung cancer tr ... Full text Link to item Cite

Iterative inversion of deformation vector fields with feedback control.

Journal Article Med Phys · July 2018 PURPOSE: Often, the inverse deformation vector field (DVF) is needed together with the corresponding forward DVF in four-dimesional (4D) reconstruction and dose calculation, adaptive radiation therapy, and simultaneous deformable registration. This study a ... Full text Link to item Cite

A Novel method to generate on-board 4D MRI using prior 4D MRI and on-board kV projections from a conventional LINAC for target localization in liver SBRT.

Journal Article Med Phys · July 2018 PURPOSE: On-board MRI can provide superb soft tissue contrast for improving liver SBRT localization. However, the availability of on-board MRI in clinics is extremely limited. On the contrary, on-board kV imaging systems are widely available on radiotherap ... Full text Link to item Cite

Advances in Patient Setup and Target Localization

Chapter · May 24, 2018 This new book educates readers about new technologies before they appear in hospitals, enabling medical physicists and clinicians to prepare for new technologies thoroughly and proactively, and provide better patient care once new equipment ... ... Cite

Low dose CBCT reconstruction via prior contour based total variation (PCTV) regularization: a feasibility study.

Journal Article Phys Med Biol · April 19, 2018 PURPOSE: compressed sensing reconstruction using total variation (TV) tends to over-smooth the edge information by uniformly penalizing the image gradient. The goal of this study is to develop a novel prior contour based TV (PCTV) method to enhance the edg ... Full text Link to item Cite

Improving Quality and Consistency in NRG Oncology Radiation Therapy Oncology Group 0631 for Spine Radiosurgery via Knowledge-Based Planning.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2018 PURPOSE: To use knowledge-based planning (KBP) as a method of producing high-quality, consistent, protocol-compliant treatment plans in a complex setting of spine stereotactic body radiation therapy on NRG Oncology Radiation Therapy Oncology Group (RTOG) 0 ... Full text Link to item Cite

Application of the 4-D XCAT Phantoms in Biomedical Imaging and Beyond.

Journal Article IEEE Trans Med Imaging · March 2018 The four-dimensional (4-D) eXtended CArdiac-Torso (XCAT) series of phantoms was developed to provide accurate computerized models of the human anatomy and physiology. The XCAT series encompasses a vast population of phantoms of varying ages from newborn to ... Full text Link to item Cite

Image acquisition optimization of a limited-angle intrafraction verification (LIVE) system for lung radiotherapy.

Journal Article Med Phys · January 2018 PURPOSE: Limited-angle intrafraction verification (LIVE) has been previously developed for four-dimensional (4D) intrafraction target verification either during arc delivery or between three-dimensional (3D)/IMRT beams. Preliminary studies showed that LIVE ... Full text Link to item Cite

Principal component reconstruction (PCR) for cine CBCT with motion learning from 2D fluoroscopy.

Journal Article Med Phys · January 2018 PURPOSE: This work aims to generate cine CT images (i.e., 4D images with high-temporal resolution) based on a novel principal component reconstruction (PCR) technique with motion learning from 2D fluoroscopic training images. METHODS: In the proposed PCR m ... Full text Link to item Cite

An Ensemble Approach to Knowledge-Based Intensity-Modulated Radiation Therapy Planning.

Journal Article Front Oncol · 2018 Knowledge-based planning (KBP) utilizes experienced planners' knowledge embedded in prior plans to estimate optimal achievable dose volume histogram (DVH) of new cases. In the regression-based KBP framework, previously planned patients' anatomical features ... Full text Open Access Link to item Cite

Assessment of concurrent stereotactic radiosurgery and bevacizumab treatment of recurrent malignant gliomas using multi-modality MRI imaging and radiomics analysis.

Journal Article J Radiosurg SBRT · 2018 PURPOSE: To assess the response and predict the overall survival (OS) of recurrent malignant gliomas (MG) patients treated with concurrent BVZ/SRS using multi-modality MRI imaging and radiomics analysis.Methods and materials: SRS was delivered in a single ... Link to item Cite

Dosimetric Characterization of an Intensity-modulated X-Ray Brachytherapy System.

Journal Article J Med Phys · 2018 PURPOSE: An intensity-modulated X-ray brachytherapy system is being developed for various clinical applications. This new system makes it possible for clinical staff to control energy as well as dose rate for different tumor sites according to their sizes ... Full text Link to item Cite

Accelerating volumetric cine MRI (VC-MRI) using undersampling for real-time 3D target localization/tracking in radiation therapy: a feasibility study.

Journal Article Phys Med Biol · December 14, 2017 PURPOSE: To accelerate volumetric cine MRI (VC-MRI) using undersampled 2D-cine MRI to provide real-time 3D guidance for gating/target tracking in radiotherapy. METHODS: 4D-MRI is acquired during patient simulation. One phase of the prior 4D-MRI is selected ... Full text Link to item Cite

Clinical Study of Orthogonal-View Phase-Matched Digital Tomosynthesis for Lung Tumor Localization.

Journal Article Technol Cancer Res Treat · December 2017 BACKGROUND AND PURPOSE: Compared to cone-beam computed tomography, digital tomosynthesis imaging has the benefits of shorter scanning time, less imaging dose, and better mechanical clearance for tumor localization in radiation therapy. However, for lung tu ... Full text Link to item Cite

Characterization of Water-Clear Polymeric Gels for Use as Radiotherapy Bolus.

Journal Article Technol Cancer Res Treat · December 2017 Our purpose was to investigate polymeric gels for use as a highly transparent radiotherapy bolus and determine the relevant physical and dosimetric properties. We first quantified tensile properties (maximum stress, strain, and Young modulus) for various p ... Full text Link to item Cite

Development of a Computerized 4-D MRI Phantom for Liver Motion Study.

Journal Article Technol Cancer Res Treat · December 2017 PURPOSE: To develop a 4-dimensional computerized magnetic resonance imaging phantom with image textures extracted from real patient scans for liver motion studies. METHODS: The proposed phantom was developed based on the current version of 4-dimensional ex ... Full text Link to item Cite

Dosimetric Analysis of Microscopic Disease in SBRT for Lung Cancers.

Journal Article Technol Cancer Res Treat · December 2017 OBJECTIVE: The objective of this study is to theoretically and experimentally evaluate the dosimetry in the microscopic disease regions surrounding the tumor under stereotactic body radiation therapy of lung cancer. METHODS: For simplicity, the tumor was c ... Full text Link to item Cite

Outlier identification in radiation therapy knowledge-based planning: A study of pelvic cases.

Journal Article Med Phys · November 2017 PURPOSE: The purpose of this study was to apply statistical metrics to identify outliers and to investigate the impact of outliers on knowledge-based planning in radiation therapy of pelvic cases. We also aimed to develop a systematic workflow for identify ... Full text Link to item Cite

Biopsy of enlarging lesions after stereotactic radiosurgery for brain metastases frequently reveals radiation necrosis.

Journal Article Neuro Oncol · October 1, 2017 BACKGROUND: Stereotactic radiosurgery (SRS) offers excellent local control for brain metastases (BM) with low rates of toxicity. Radiation necrosis (RN) may occur after treatment and is challenging to distinguish from local recurrence (LR). We evaluated en ... Full text Link to item Cite

AAPM-RSS Medical Physics Practice Guideline 9.a. for SRS-SBRT.

Journal Article J Appl Clin Med Phys · September 2017 The American Association of Physicists in Medicine (AAPM) is a nonprofit professional society whose primary purposes are to advance the science, education, and professional practice of medical physics. The AAPM has more than 8,000 members and is the princi ... Full text Link to item Cite

Respiratory signal prediction based on adaptive boosting and multi-layer perceptron neural network.

Journal Article Phys Med Biol · August 3, 2017 To improve the prediction accuracy of respiratory signals using adaptive boosting and multi-layer perceptron neural network (ADMLP-NN) for gated treatment of moving target in radiation therapy. The respiratory signals acquired using a real-time position ma ... Full text Link to item Cite

Accelerated Brain DCE-MRI Using Iterative Reconstruction With Total Generalized Variation Penalty for Quantitative Pharmacokinetic Analysis: A Feasibility Study.

Journal Article Technol Cancer Res Treat · August 2017 PURPOSE: To investigate the feasibility of using undersampled k-space data and an iterative image reconstruction method with total generalized variation penalty in the quantitative pharmacokinetic analysis for clinical brain dynamic contrast-enhanced magne ... Full text Link to item Cite

Exploring the Margin Recipe for Online Adaptive Radiation Therapy for Intermediate-Risk Prostate Cancer: An Intrafractional Seminal Vesicles Motion Analysis.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2017 PURPOSE: To provide a benchmark for seminal vesicle (SV) margin selection to account for intrafractional motion and to investigate the effectiveness of 2 motion surrogates in predicting intrafractional SV coverage. METHODS AND MATERIALS: Fifteen prostate p ... Full text Link to item Cite

Reducing scan angle using adaptive prior knowledge for a limited-angle intrafraction verification (LIVE) system for conformal arc radiotherapy.

Journal Article Phys Med Biol · May 7, 2017 The purpose of this study is to develop an adaptive prior knowledge guided image estimation technique to reduce the scan angle needed in the limited-angle intrafraction verification (LIVE) system for 4D-CBCT reconstruction. The LIVE system has been previou ... Full text Link to item Cite

Quantitative Approach to Failure Mode and Effect Analysis for Linear Accelerator Quality Assurance.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2017 PURPOSE: To determine clinic-specific linear accelerator quality assurance (QA) TG-142 test frequencies, to maximize physicist time efficiency and patient treatment quality. METHODS AND MATERIALS: A novel quantitative approach to failure mode and effect an ... Full text Link to item Cite

Retrospective four-dimensional magnetic resonance imaging with image-based respiratory surrogate: a sagittal-coronal-diaphragm point of intersection motion tracking method.

Journal Article J Med Imaging (Bellingham) · April 2017 A four-dimensional magnetic resonance imaging (4-D-MRI) technique with Sagittal-Coronal-Diaphragm Point-of-Intersection (SCD-PoI) as a respiratory surrogate is proposed. To develop an image-based respiratory surrogate, the SCD-PoI motion tracking method is ... Full text Link to item Cite

Estimating 4D-CBCT from prior information and extremely limited angle projections using structural PCA and weighted free-form deformation for lung radiotherapy.

Journal Article Med Phys · March 2017 PURPOSE: To investigate the feasibility of using structural-based principal component analysis (PCA) motion-modeling and weighted free-form deformation to estimate on-board 4D-CBCT using prior information and extremely limited angle projections for potenti ... Full text Link to item Cite

Four-dimensional diffusion-weighted MR imaging (4D-DWI): a feasibility study.

Journal Article Med Phys · February 2017 PURPOSE: Diffusion-weighted Magnetic Resonance Imaging (DWI) has been shown to be a powerful tool for cancer detection with high tumor-to-tissue contrast. This study aims to investigate the feasibility of developing a four-dimensional DWI technique (4D-DWI ... Full text Link to item Cite

Impact of moving target on measurement accuracy in 3D and 4D PET imaging-a phantom study.

Journal Article Adv Radiat Oncol · 2017 PURPOSE: The purpose of this study was to evaluate the impact of tumor motion on maximum standardized uptake value (SUVmax) and metabolic tumor volume (MTV) measurements in both 3-dimensional and respiratory-correlated, 4-dimensional positron emission tomo ... Full text Link to item Cite

An in-house protocol for improved flood field calibration of TrueBeam FFF cine imaging.

Journal Article J Appl Clin Med Phys · January 2017 PURPOSE: TrueBeams equipped with the 40 × 30 cm2 Electronic Portal Imaging Devices (EPIDs) are prone to image saturation at the image center when used with flattening filter free (FFF) photon energies. While cine imaging during treatment may not saturate b ... Full text Link to item Cite

Single fraction stereotactic radiosurgery for multiple brain metastases.

Journal Article Adv Radiat Oncol · 2017 INTRODUCTION: Due to the neurocognitive side effects of whole brain radiation therapy (WBRT), stereotactic radiosurgery (SRS) is being used with increasing frequency. The use of SRS is expanding for patients with multiple (>4) brain metastases (BM). This s ... Full text Open Access Link to item Cite

High-resolution imaging immunolabeled large tissues

Conference Optics InfoBase Conference Papers · January 1, 2017 We combined large sample resin embedding with immunofluorescence staining to acquire biomolecules profiles with high spatial-resolution. After evaluating the compatibility of this method and filtering embedding resin, we achieved to high-resolution image i ... Full text Cite

A simple, rapid method to precisely locate mRNAs of intact mouse brain via fluorescence tomography

Conference Optics InfoBase Conference Papers · January 1, 2017 To precisely locate mRNAs of mouse brain, a simple, rapid method was developed via combining whole mount in situ hybridization and fluorescence tomography, with cytoarchitectonic landmarks provided by propidium iodide real-time counterstaining during the i ... Full text Cite

Markerless Four-Dimensional-Cone Beam Computed Tomography Projection-Phase Sorting Using Prior Knowledge and Patient Motion Modeling: A Feasibility Study.

Journal Article Cancer Transl Med · 2017 AIM: During cancer radiotherapy treatment, on-board four-dimensional-cone beam computed tomography (4D-CBCT) provides important patient 4D volumetric information for tumor target verification. Reconstruction of 4D-CBCT images requires sorting of acquired p ... Open Access Link to item Cite

Sensitivity of 3D Dose Verification to Multileaf Collimator Misalignments in Stereotactic Body Radiation Therapy of Spinal Tumor.

Journal Article Technol Cancer Res Treat · December 2016 PURPOSE: This study aimed to detect the sensitivity of Delt 4 on ordinary field multileaf collimator misalignments, system misalignments, random misalignments, and misalignments caused by gravity of the multileaf collimator in stereotactic body radiation t ... Full text Link to item Cite

A probability-based multi-cycle sorting method for 4D-MRI: A simulation study.

Journal Article Med Phys · December 2016 PURPOSE: To develop a novel probability-based sorting method capable of generating multiple breathing cycles of 4D-MRI images and to evaluate performance of this new method by comparing with conventional phase-based methods in terms of image quality and tu ... Full text Link to item Cite

Comparisons of volumetric modulated arc therapy (VMAT) quality assurance (QA) systems: sensitivity analysis to machine errors.

Journal Article Radiat Oncol · November 7, 2016 BACKGROUND: In volumetric modulated arc therapy (VMAT), gantry angles, dose rate and the MLC positions vary with the radiation delivery. The quality assurance (QA) system should be able to catch the planning and machine errors. The aim of this study was to ... Full text Open Access Link to item Cite

Assessment of Treatment Response With Diffusion-Weighted MRI and Dynamic Contrast-Enhanced MRI in Patients With Early-Stage Breast Cancer Treated With Single-Dose Preoperative Radiotherapy: Initial Results.

Journal Article Technol Cancer Res Treat · October 2016 Single-dose preoperative stereotactic body radiotherapy is a novel radiotherapy technique for the early-stage breast cancer, and the treatment response pattern of this technique needs to be investigated on a quantitative basis. In this work, dynamic contra ... Full text Link to item Cite

Simultaneous 4D-CBCT reconstruction with sliding motion constraint.

Journal Article Med Phys · October 2016 PURPOSE: Current approaches using deformable vector field (DVF) for motion-compensated 4D-cone beam CT (CBCT) reconstruction typically utilize an isotropically smoothed DVF between different respiration phases. Such isotropically smoothed DVF does not work ... Full text Link to item Cite

Re-examining TG-142 recommendations in light of modern techniques for linear accelerator based radiosurgery.

Journal Article Med Phys · October 2016 PURPOSE: The recent development of multifocal stereotactic radiosurgery (SRS) using a single isocenter volumetric modulated arc theory (VMAT) technique warrants a re-examination of the quality assurance (QA) tolerances for routine mechanical QA recommended ... Full text Link to item Cite

Diode-based transmission detector for IMRT delivery monitoring: a validation study.

Journal Article J Appl Clin Med Phys · September 8, 2016 The purpose of this work was to evaluate the potential of a new transmission detector for real-time quality assurance of dynamic-MLC-based radiotherapy. The accuracy of detecting dose variation and static/dynamic MLC position deviations was measured, as we ... Full text Open Access Link to item Cite

Diode-based transmission detector for IMRT delivery monitoring: a validation study.

Journal Article J Appl Clin Med Phys · September 2016 The purpose of this work was to evaluate the potential of a new transmission detector for real-time quality assurance of dynamic-MLC-based radiotherapy. The accuracy of detecting dose variation and static/dynamic MLC position deviations was measured, as we ... Full text Link to item Cite

Evaluation of the effect of transcytolemmal water exchange analysis for therapeutic response assessment using DCE-MRI: a comparison study.

Journal Article Phys Med Biol · July 7, 2016 This study compares the shutter-speed (SS) and the Tofts models as used in assessing therapeutic response in a longitudinal DCE-MRI experiment. Sixteen nu/nu mice with implanted colorectal adenocarcinoma cell line (LS-174T) were randomly assigned into trea ... Full text Link to item Cite

Scatter Reduction and Correction for Dual-Source Cone-Beam CT Using Prepatient Grids.

Journal Article Technol Cancer Res Treat · June 2016 PURPOSE: Scatter significantly limits the application of the dual-source cone-beam computed tomography by inducing scatter artifacts and degrading contrast-to-noise ratio, Hounsfield-unit accuracy, and image uniformity. Although our previously developed in ... Full text Link to item Cite

A Technique for Generating Volumetric Cine-Magnetic Resonance Imaging.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2016 PURPOSE: The purpose of this study was to develop a techique to generate on-board volumetric cine-magnetic resonance imaging (VC-MRI) using patient prior images, motion modeling, and on-board 2-dimensional cine MRI. METHODS AND MATERIALS: One phase of a 4- ... Full text Link to item Cite

Tomosynthesis Applications in Radiation Oncology

Chapter · April 19, 2016 Cite

Dynamic fractal signature dissimilarity analysis for therapeutic response assessment using dynamic contrast-enhanced MRI.

Journal Article Med Phys · March 2016 PURPOSE: To develop a dynamic fractal signature dissimilarity (FSD) method as a novel image texture analysis technique for the quantification of tumor heterogeneity information for better therapeutic response assessment with dynamic contrast-enhanced (DCE) ... Full text Link to item Cite

An efficient calculation method for pharmacokinetic parameters in brain permeability study using dynamic contrast-enhanced MRI.

Journal Article Magn Reson Med · February 2016 PURPOSE: To develop an efficient method for calculating pharmacokinetic (PK) parameters in brain DCE-MRI permeability studies. METHODS: A linear least-squares fitting algorithm based on a derivative expression of the two-compartment PK model was proposed t ... Full text Link to item Cite

On the sensitivity of TG-119 and IROC credentialing to TPS commissioning errors.

Journal Article J Appl Clin Med Phys · January 8, 2016 We investigate the sensitivity of IMRT commissioning using the TG-119 C-shape phantom and credentialing with the IROC head and neck phantom to treatment planning system commissioning errors. We introduced errors into the various aspects of the commissionin ... Full text Open Access Link to item Cite

Physics considerations for single-isocenter, volumetric modulated arc radiosurgery for treatment of multiple intracranial targets.

Conference Pract Radiat Oncol · 2016 OBJECTIVE: Our purpose was to address challenges associated with single-isocenter radiosurgery for multiple intracranial targets (SIRMIT) including increased sensitivity to rotational uncertainties (resulting from distance of the targets from isocenter) as ... Full text Link to item Cite

Accuracy of respiratory motion measurement of 4D-MRI: A comparison between cine and sequential acquisition.

Journal Article Med Phys · January 2016 PURPOSE: The authors have recently developed a cine-mode T2*/T1-weighted 4D-MRI technique and a sequential-mode T2-weighted 4D-MRI technique for imaging respiratory motion. This study aims at investigating which 4D-MRI image acquisition mode, cine or seque ... Full text Link to item Cite

On the sensitivity of TG-119 and IROC credentialing to TPS commissioning errors.

Journal Article J Appl Clin Med Phys · January 2016 We investigate the sensitivity of IMRT commissioning using the TG-119 C-shape phantom and credentialing with the IROC head and neck phantom to treatment planning system commissioning errors. We introduced errors into the various aspects of the commissionin ... Full text Link to item Cite

Novel Technologies for Improved Treatment Outcome and Patient Safety in Cancer Radiotherapy.

Journal Article Biomed Res Int · 2016 Full text Link to item Cite

Atlas-guided prostate intensity modulated radiation therapy (IMRT) planning.

Journal Article Phys Med Biol · September 21, 2015 An atlas-based IMRT planning technique for prostate cancer was developed and evaluated. A multi-dose atlas was built based on the anatomy patterns of the patients, more specifically, the percent distance to the prostate and the concaveness angle formed by ... Full text Link to item Cite

T2-weighted four dimensional magnetic resonance imaging with result-driven phase sorting.

Journal Article Med Phys · August 2015 PURPOSE: T2-weighted MRI provides excellent tumor-to-tissue contrast for target volume delineation in radiation therapy treatment planning. This study aims at developing a novel T2-weighted retrospective four dimensional magnetic resonance imaging (4D-MRI) ... Full text Link to item Cite

Dosimetric verification of lung cancer treatment using the CBCTs estimated from limited-angle on-board projections.

Journal Article Med Phys · August 2015 PURPOSE: Lung cancer treatment is susceptible to treatment errors caused by interfractional anatomical and respirational variations of the patient. On-board treatment dose verification is especially critical for the lung stereotactic body radiation therapy ... Full text Link to item Cite

Utilizing knowledge from prior plans in the evaluation of quality assurance.

Journal Article Phys Med Biol · June 21, 2015 Increased interest regarding sensitivity of pre-treatment intensity modulated radiotherapy and volumetric modulated arc radiotherapy (VMAT) quality assurance (QA) to delivery errors has led to the development of dose-volume histogram (DVH) based analysis. ... Full text Link to item Cite

TH-CD-207-09: Retrospective 4D-MRI with a Novel Image-Based Surrogate: A Sagittal-Coronal-Diaphragm Point of Intersection (SCD-PoI) Motion Tracking Method.

Journal Article Med Phys · June 2015 PURPOSE: The unreliable stability of internal respiratory surrogates and inconvenience of external respiratory surrogates for current retrospective 4D-MRI techniques largely affects the image quality of 4D-MRI. This study aims at developing image-based sur ... Full text Link to item Cite

TH-CD-204-10: Probability-Driven Sorting Method for Reconstructing Variation-Independent 4D-MRI.

Journal Article Med Phys · June 2015 PURPOSE: To develop a novel probability-driven sorting method that inherently incorporates breathing variations in the sorting process and 4D reconstruction. METHODS: The probability-driven sorting method has two key steps: (a) determination of multiple pr ... Full text Link to item Cite

TH-CD-204-09: Physiological Modeling of Lung Motion Based On Hyperpolarized Gas Tagging MRI.

Journal Article Med Phys · June 2015 PURPOSE: To model the respiratory motion of lung based on the physiological ground truth measured with hyperpolarized (HP) gas tagging magnetic resonance imaging (MRI). METHODS: A novel 4D model was established to investigate the respiratory motion of lung ... Full text Link to item Cite

WE-AB-BRA-11: Development of Physiological-Based Virtual Thorax Phantoms for Evaluation of Deformable Image Registration.

Journal Article Med Phys · June 2015 PURPOSE: To develop a methodology of constructing physiological-based virtual thorax phantom based on hyperpolarized (HP) gas tagging MRI for evaluating deformable image registration (DIR). METHODS: Three healthy subjects were imaged at both the end-of-inh ... Full text Link to item Cite

WE-G-BRD-06: Volumetric Cine MRI (VC-MRI) Estimated Based On Prior Knowledge for On-Board Target Localization.

Conference Med Phys · June 2015 PURPOSE: To develop a technique to generate on-board VC-MRI using patient prior 4D-MRI, motion modeling and on-board 2D-cine MRI for real-time 3D target verification of liver and lung radiotherapy. METHODS: The end-expiration phase images of a 4D-MRI acqui ... Full text Link to item Cite

WE-AB-BRA-03: Displacement Vector Field (DVF) Error Correction Using Sparsely Distributed Ground-Truth Displacement Vectors.

Journal Article Med Phys · June 2015 PURPOSE: This study aims to develop a technique capable of reducing errors in deformable image registration (DIR) by integrating information of sparsely distributed ground-truth displacement vectors into a dense DVF. METHODS: An in-house developed lung mot ... Full text Link to item Cite

SU-E-J-223: A BOLD Contrast Imaging Sequence to Evaluate Oxygenation Changes Due to Breath Holding for Breast Radiotherapy: A Pilot Study.

Journal Article Med Phys · June 2015 PURPOSE: To develop a robust MRI sequence to measure BOLD breath hold induced contrast in context of breast radiotherapy. METHODS: Two sequences were selected from prior studies as candidates to measure BOLD contrast attributable to breath holding within t ... Full text Link to item Cite

SU-D-BRA-01: Therapeutic Response Assessment Using a Novel Gray Level Local Power Matrix (GLLPM) in DCE-MRI Texture Analysis: Feasibility Study.

Journal Article Med Phys · June 2015 PURPOSE: Most current DCE-MRI texture analysis methods focus on the spatial information of chosen contrast-enhanced MR volumes or pharmacokinetic (PK) parameter maps, and the temporal information is not well included. This work proposed a novel texture mat ... Full text Link to item Cite

TU-AB-303-06: Does Online Adaptive Radiation Therapy Mean Zero Margin for Intermediate-Risk Prostate Cancer? An Intra-Fractional Seminal Vesicles Motion Analysis.

Journal Article Med Phys · June 2015 PURPOSE: To provide benchmark for seminal vesicles (SVs) margin selection to account for intra-fractional motion; and to investigate the effectiveness of two motion surrogates in predicting intra-fractional SV underdosage. METHODS: 9 prostate SBRT patients ... Full text Link to item Cite

TH-CD-303-06: Deformable Registration-Based Image Estimation Method for 4D CBCT Using Region-Based PCA.

Conference Med Phys · June 2015 PURPOSE: To investigate the feasibility of using region-based principal component analysis (PCA) for motion modeling to estimate on-board 4D-CBCT using prior information and limited angle projections for potential 4D target verification of lung radiotherap ... Full text Link to item Cite

TH-AB-303-02: An Investigation of Respiratory Signal Parameters for Multiple-Step Ahead Prediction of Surrogate Motion.

Conference Med Phys · June 2015 PURPOSE: Target tracking or gating the radiation beam using real-time imaging and surrogate motion monitoring methods are employed for dynamic tracking treatment or respiratory-gated radiotherapy. This method requires tumor motion prediction far enough in ... Full text Link to item Cite

WE-D-303-05: Dosimetric Accuracy of CBCT Images Estimated by a Motion Modeling and Free-Form Deformation Technique for Radiotherapy of Lung Cancer.

Conference Med Phys · June 2015 PURPOSE: To investigate the dosimetric accuracy of CBCTs estimated by a motion modeling and free-form deformation(MM-FD) technique for radiotherapy of lung cancer. METHODS: Various inter-fractional variations featuring patient motion pattern change, tumor ... Full text Link to item Cite

WE-AB-303-09: Rapid Projection Computations for On-Board Digital Tomosynthesis in Radiation Therapy.

Conference Med Phys · June 2015 PURPOSE: To facilitate fast and accurate iterative volumetric image reconstruction from limited-angle on-board projections. METHODS: Intrafraction motion hinders the clinical applicability of modern radiotherapy techniques, such as lung stereotactic body r ... Full text Link to item Cite

SU-E-T-293: Dosimetric Analysis of Microscopic Disease in SBRT for Lung Cancers.

Conference Med Phys · June 2015 PURPOSE: To evaluate the dosimetry of microscopic disease (MD) region of lung cancer in stereotactic body radiation therapy (SBRT). METHODS: For simplicity, we assume organ moves along one dimension. The probability distribution function of tumor position ... Full text Link to item Cite

SU-E-J-26: A Novel Technique for Markerless Self-Sorted 4D-CBCT Using Patient Motion Modeling: A Feasibility Study.

Conference Med Phys · June 2015 PURPOSE: To develop an automatic markerless 4D-CBCT projection sorting technique by using a patient respiratory motion model extracted from the planning 4D-CT images. METHODS: Each phase of onboard 4D-CBCT is considered as a deformation of one phase of the ... Full text Link to item Cite

SU-E-I-40: Phantom Research On Monochromatic Images Taken by Dual CBCT with Multiple Energy Sets.

Conference Med Phys · June 2015 PURPOSE: To evaluate the quality of monochromatic images at the same virtual monochromatic energy using dual cone-beam computed tomography (CBCT) with either kV/kV or MV/kV or MV/MV energy sets. METHODS: CT images of Catphan 504 phantom were acquired using ... Full text Link to item Cite

SU-E-T-690: Sensitivity Analysis to Machine Error: Comparisons of VMAT QA Systems.

Journal Article Med Phys · June 2015 PURPOSE: In VMAT delivery, the gantry angles, dose rate and the MLC positions are all modulated. It is therefore necessary to perform pre-treatment QA to detect any possible errors either in the plan or machine delivery system. Previously we developed a QA ... Full text Link to item Cite

MO‐G‐304‐03: Development of Knowledge Models for IMRT Treatment Planning Utilizing a Rapid Learning Approach

Conference Medical Physics · June 2015 Purpose:We present an implementation of the knowledge‐based planning method utilizing a rapid learning approach which enables the accurate evolution of models as new data are collected during daily clinical practi ... Full text Cite

TH-CD-303-12: Sliding Motion Compensated Simultaneous 4D-CBCT Reconstruction

Conference Medical Physics · June 2015 Full text Cite

Flattening filter-free accelerators: a report from the AAPM Therapy Emerging Technology Assessment Work Group.

Journal Article J Appl Clin Med Phys · May 8, 2015 This report describes the current state of flattening filter-free (FFF) radiotherapy beams implemented on conventional linear accelerators, and is aimed primarily at practicing medical physicists. The Therapy Emerging Technology Assessment Work Group of th ... Full text Open Access Link to item Cite

A Monte Carlo simulation framework for electron beam dose calculations using Varian phase space files for TrueBeam Linacs.

Journal Article Med Phys · May 2015 PURPOSE: To develop a framework for accurate electron Monte Carlo dose calculation. In this study, comprehensive validations of vendor provided electron beam phase space files for Varian TrueBeam Linacs against measurement data are presented. METHODS: In t ... Full text Link to item Cite

Preliminary clinical evaluation of a 4D-CBCT estimation technique using prior information and limited-angle projections.

Journal Article Radiother Oncol · April 2015 BACKGROUND AND PURPOSE: A technique has been previously reported to estimate high-quality 4D-CBCT using prior information and limited-angle projections. This study is to investigate its clinical feasibility through both phantom and patient studies. MATERIA ... Full text Link to item Cite

Quantitative comparison of automatic and manual IMRT optimization for prostate cancer: the benefits of DVH prediction.

Journal Article J Appl Clin Med Phys · March 8, 2015 A recent publication indicated that the patient anatomical feature (PAF) model was capable of predicting optimal objectives based on past experience. In this study, the benefits of IMRT optimization using PAF-predicted objectives as guidance for prostate w ... Full text Open Access Link to item Cite

Standardized beam bouquets for lung IMRT planning.

Journal Article Phys Med Biol · March 7, 2015 The selection of the incident angles of the treatment beams is a critical component of intensity modulated radiation therapy (IMRT) planning for lung cancer due to significant variations in tumor location, tumor size and patient anatomy. We investigate the ... Full text Link to item Cite

From active shape model to active optical flow model: a shape-based approach to predicting voxel-level dose distributions in spine SBRT.

Journal Article Phys Med Biol · March 7, 2015 Prediction of achievable dose distribution in spine stereotactic body radiation therapy (SBRT) can help in designing high-quality treatment plans to maximally protect spinal cords and to effectively control tumours. Dose distributions at spinal cords are p ... Full text Link to item Cite

Four dimensional magnetic resonance imaging with retrospective k-space reordering: a feasibility study.

Journal Article Med Phys · February 2015 PURPOSE: Current four dimensional magnetic resonance imaging (4D-MRI) techniques lack sufficient temporal/spatial resolution and consistent tumor contrast. To overcome these limitations, this study presents the development and initial evaluation of a new s ... Full text Link to item Cite

Dosimetric comparison of preoperative single-fraction partial breast radiotherapy techniques: 3D CRT, noncoplanar IMRT, coplanar IMRT, and VMAT.

Journal Article J Appl Clin Med Phys · January 8, 2015 The purpose of this study was to compare dosimetric parameters of treatment plans among four techniques for preoperative single-fraction partial breast radiotherapy in order to select an optimal treatment technique. The techniques evaluated were noncoplana ... Full text Link to item Cite

Impact of dose calculation accuracy during optimization on lung IMRT plan quality.

Journal Article J Appl Clin Med Phys · January 8, 2015 The purpose of this study was to evaluate the effect of dose calculation accuracy and the use of an intermediate dose calculation step during the optimization of intensity-modulated radiation therapy (IMRT) planning on the final plan quality for lung cance ... Full text Link to item Cite

Defining the optimal planning target volume in image-guided stereotactic radiosurgery of brain metastases: results of a randomized trial.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2015 PURPOSE: To identify an optimal margin about the gross target volume (GTV) for stereotactic radiosurgery (SRS) of brain metastases, minimizing toxicity and local recurrence. METHODS AND MATERIALS: Adult patients with 1 to 3 brain metastases less than 4 cm ... Full text Link to item Cite

Quality assurance for online adapted treatment plans: benchmarking and delivery monitoring simulation.

Journal Article Med Phys · January 2015 PURPOSE: An important challenge facing online adaptive radiation therapy is the development of feasible and efficient quality assurance (QA). This project aimed to validate the deliverability of online adapted plans and develop a proof-of-concept online de ... Full text Link to item Cite

Dosimetric comparison of preoperative single-fraction partial breast radiotherapy techniques: 3D CRT, noncoplanar IMRT, coplanar IMRT, and VMAT

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2015 The purpose of this study was to compare dosimetric parameters of treatment plans among four techniques for preoperative single-fraction partial breast radiotherapy in order to select an optimal treatment technique. The techniques evaluated were noncoplana ... Cite

An active optical flow model for dose prediction in spinal sbrt plans

Journal Article Lecture Notes in Computational Vision and Biomechanics · January 1, 2015 Accurate dose predication is critical to spinal stereotactic body radiation therapy (SBRT). It enables radiation oncologists and planners to design treatment plans that maximally protect spinal cord while effectively controlling surrounding tumors. Spinal ... Full text Cite

Quantitative comparison of automatic and manual IMRT optimization for prostate cancer: The benefits of DVH prediction

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2015 A recent publication indicated that the patient anatomical feature (PAF) model was capable of predicting optimal objectives based on past experience. In this study, the benefits of IMRT optimization using PAF-predicted objectives as guidance for prostate w ... Full text Cite

Knowledge modeling for computer aided treatment planning

Conference IFMBE Proceedings · January 1, 2015 The purpose for this study is to develop robust and comprehensive knowledge models which can provide patient specific prediction of achievable dose distribution in radiation therapy plans for a wide range of cancer types. These models are useful tools to g ... Full text Cite

Knowledge based automatic beam angle determination for lung IMRT planning

Conference IFMBE Proceedings · January 1, 2015 We present an efficient knowledge based automatic beam configuration determination method by utilizing patient-specific anatomy and tumor geometry information and a beam bouquet atlas. The proposed technique is based on learning the relationship between pa ... Full text Cite

A rapid learning approach for the knowledge modeling of radiation therapy plan

Conference IFMBE Proceedings · January 1, 2015 The purpose of this study is to implement a rapid learning method to train the knowledge models to predict the organ-at-risk (OAR) dose sparing in radiation therapy (RT) based on an array of patient anatomical features. We also aim to establish the evaluat ... Full text Cite

Is diaphragm motion a good surrogate for liver tumor motion?

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2014 PURPOSE: To evaluate the relationship between liver tumor motion and diaphragm motion. METHODS AND MATERIALS: Fourteen patients with hepatocellular carcinoma (10 of 14) or liver metastases (4 of 14) undergoing radiation therapy were included in this study. ... Full text Link to item Cite

A hardware investigation of robotic SPECT for functional and molecular imaging onboard radiation therapy systems.

Journal Article Med Phys · November 2014 PURPOSE: To construct a robotic SPECT system and to demonstrate its capability to image a thorax phantom on a radiation therapy flat-top couch, as a step toward onboard functional and molecular imaging in radiation therapy. METHODS: A robotic SPECT imaging ... Full text Link to item Cite

BM-17 * FINAL RESULTS OF A RANDOMIZED TRIAL TO IDENTIFY THE OPTIMAL PLANNING TARGET VOLUME IN IMAGE-GUIDED STEREOTACTIC RADIOSURGERY OF BRAIN METASTASES

Journal Article Neuro-Oncology · November 1, 2014 Full text Cite

Investigation of sagittal image acquisition for 4D-MRI with body area as respiratory surrogate.

Journal Article Med Phys · October 2014 PURPOSE: The authors have recently developed a novel 4D-MRI technique for imaging organ respiratory motion employing cine acquisition in the axial plane and using body area (BA) as a respiratory surrogate. A potential disadvantage associated with axial ima ... Full text Link to item Cite

Automatic Determination of Beam Angles in Lung IMRT Planning

Conference International Journal of Radiation Oncology*Biology*Physics · September 2014 Full text Cite

On the feasibility of polyurethane based 3D dosimeters with optical CT for dosimetric verification of low energy photon brachytherapy seeds.

Journal Article Med Phys · July 2014 PURPOSE: To investigate the feasibility of and challenges yet to be addressed to measure dose from low energy (effective energy <50 keV) brachytherapy sources (Pd-103, Cs-131, and I-125) using polyurethane based 3D dosimeters with optical CT. METHODS: The ... Full text Link to item Cite

Review of treatment assessment using DCE-MRI in breast cancer radiation therapy.

Journal Article World J Methodol · June 26, 2014 As a noninvasive functional imaging technique, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is being used in oncology to measure properties of tumor microvascular structure and permeability. Studies have shown that parameters derived from ... Full text Link to item Cite

Stereotactic body radiotherapy: a critical review for nonradiation oncologists.

Journal Article Cancer · April 1, 2014 Stereotactic body radiotherapy (SBRT) involves the treatment of extracranial primary tumors or metastases with a few, high doses of ionizing radiation. In SBRT, tumor kill is maximized and dose to surrounding tissue is minimized, by precise and accurate de ... Full text Link to item Cite

Four-dimensional magnetic resonance imaging using axial body area as respiratory surrogate: initial patient results.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2014 PURPOSE: To evaluate the feasibility of a retrospective binning technique for 4-dimensional magnetic resonance imaging (4D-MRI) using body area (BA) as a respiratory surrogate. METHODS AND MATERIALS: Seven patients with hepatocellular carcinoma (4 of 7) or ... Full text Link to item Cite

Incorporating single-side sparing in models for predicting parotid dose sparing in head and neck IMRT.

Journal Article Med Phys · February 2014 PURPOSE: Sparing of single-side parotid gland is a common practice in head-and-neck (HN) intensity modulated radiation therapy (IMRT) planning. It is a special case of dose sparing tradeoff between different organs-at-risk. The authors describe an improved ... Full text Link to item Cite

A limited-angle intrafraction verification (LIVE) system for radiation therapy.

Journal Article Med Phys · February 2014 PURPOSE: Currently, no 3D or 4D volumetric x-ray imaging techniques are available for intrafraction verification of target position during actual treatment delivery or in-between treatment beams, which is critical for stereotactic radiosurgery (SRS) and st ... Full text Link to item Cite

Evaluating radiation-induced white matter changes in patients treated with stereotactic radiosurgery using diffusion tensor imaging: a pilot study.

Journal Article Technol Cancer Res Treat · February 2014 Stereotactic radiosurgery (SRS) has been an effective treatment method for brain tumors; however, few data are available regarding radiation-induced white matter (WM) damage by SRS. In this work, diffusion tensor imaging (DTI) was used to investigate WM ch ... Full text Link to item Cite

Dynamic electron arc radiotherapy (DEAR): a feasibility study.

Journal Article Phys Med Biol · January 20, 2014 Compared to other radiation therapy modalities, clinical electron beam therapy has remained practically unchanged for the past few decades even though electron beams with multiple energies are widely available on most linacs. In this paper, we present the ... Full text Link to item Cite

Onboard functional and molecular imaging: a design investigation for robotic multipinhole SPECT.

Journal Article Med Phys · January 2014 PURPOSE: Onboard imaging-currently performed primarily by x-ray transmission modalities-is essential in modern radiation therapy. As radiation therapy moves toward personalized medicine, molecular imaging, which views individual gene expression, may also b ... Full text Link to item Cite

Dosimetric effects of rotational offsets in stereotactic body radiation therapy (SBRT) for lung cancer.

Journal Article Med Dosim · 2014 To quantitatively evaluate dosimetric effects of rotational offsets in stereotactic body radiation therapy (SBRT) for lung cancer. Overall, 11 lung SBRT patients (8 female and 3 male; mean age: 75.0 years) with medially located tumors were included. Treatm ... Full text Link to item Cite

Dosimetric comparison of 3D conformal, IMRT, and V-MAT techniques for accelerated partial-breast irradiation (APBI).

Journal Article Med Dosim · 2014 The purpose is to dosimetrically compare the following 3 delivery techniques: 3-dimensional conformal radiation therapy (3D-CRT), intensity-modulated arc therapy (IMRT), and volumetric-modulated arc therapy (V-MAT) in the treatment of accelerated partial-b ... Full text Link to item Cite

Stereotactic ablative body radiotherapy (SABR) for effective palliation of metastases: factors affecting local control.

Journal Article J Radiosurg SBRT · 2014 We analyzed factors associated with inferior local control following stereotactic ablative body radiotherapy (SABR) for palliation of metastases. We reviewed records of patients receiving SABR for metastases at Duke University from 2006-2010. Biologically ... Link to item Cite

Image-guided radiation therapy and frameless stereotactic radiation therapy

Chapter · January 1, 2014 This chapter gives an overview of how to adapt diagnostic imaging technologies on to linear accelerators for image-guided frameless stereotactic radiation therapy (SRT) when the primary focus is on target localization and verification inside the treatment ... Full text Cite

RTOG 0631 phase 2/3 study of image guided stereotactic radiosurgery for localized (1-3) spine metastases: phase 2 results.

Journal Article Pract Radiat Oncol · 2014 Featured Publication PURPOSE: The phase 2 component of Radiation Therapy Oncology Group (RTOG) 0631 assessed the feasibility and safety of spine radiosurgery (SRS) for localized spine metastases in a cooperative group setting. METHODS AND MATERIALS: Patients with 1-3 spine met ... Full text Link to item Cite

Uncertainties of 4-dimensional computed tomography-based tumor motion measurement for lung stereotactic body radiation therapy.

Journal Article Pract Radiat Oncol · 2014 Featured Publication PURPOSE: To evaluate how well tumor motion measured prior to treatment based on 4-dimensional computer tomography (4DCT) reflects actual tumor motion during beam-on throughout the course of treatment. METHODS AND MATERIALS: Twenty-three patients who had lu ... Full text Link to item Cite

A technique for estimating 4D-CBCT using prior knowledge and limited-angle projections.

Journal Article Med Phys · December 2013 PURPOSE: To develop a technique to estimate onboard 4D-CBCT using prior information and limited-angle projections for potential 4D target verification of lung radiotherapy. METHODS: Each phase of onboard 4D-CBCT is considered as a deformation from one sele ... Full text Link to item Cite

Modeling the dosimetry of organ-at-risk in head and neck IMRT planning: an intertechnique and interinstitutional study.

Journal Article Med Phys · December 2013 PURPOSE: To build a statistical model to quantitatively correlate the anatomic features of structures and the corresponding dose-volume histogram (DVH) of head and neck (HN) Tomotherapy (Tomo) plans. To study if the model built upon one intensity modulated ... Full text Link to item Cite

A line-source method for aligning on-board and other pinhole SPECT systems.

Journal Article Med Phys · December 2013 PURPOSE: In order to achieve functional and molecular imaging as patients are in position for radiation therapy, a robotic multipinhole SPECT system is being developed. Alignment of the SPECT system-to the linear accelerator (LINAC) coordinate frame and to ... Full text Link to item Cite

Generation of virtual monochromatic CBCT from dual kV∕MV beam projections.

Journal Article Med Phys · December 2013 PURPOSE: To develop a novel on-board imaging technique which allows generation of virtual monochromatic (VM) cone-beam CT (CBCT) with a selected energy from combined kilovoltage (kV)∕megavoltage (MV) beam projections. METHODS: With the current orthogonal k ... Full text Link to item Cite

Strategies for automatic online treatment plan reoptimization using clinical treatment planning system: a planning parameters study.

Journal Article Med Phys · November 2013 PURPOSE: Adaptive radiation therapy for prostate cancer using online reoptimization provides an improved control of interfractional anatomy variations. However, the clinical implementation of online reoptimization is currently limited by the low efficiency ... Full text Link to item Cite

Evaluation of the effect of respiratory and anatomical variables on a Fourier technique for markerless, self-sorted 4D-CBCT.

Journal Article Phys Med Biol · October 21, 2013 A novel technique based on Fourier transform theory has been developed that directly extracts respiratory information from projections without the use of external surrogates. While the feasibility has been demonstrated with three patients, a more extensive ... Full text Link to item Cite

A novel technique for VMAT QA with EPID in cine mode on a Varian TrueBeam linac.

Journal Article Phys Med Biol · October 7, 2013 Volumetric modulated arc therapy (VMAT) is a relatively new treatment modality for dynamic photon radiation therapy. Pre-treatment quality assurance (QA) is necessary and many efforts have been made to apply electronic portal imaging device (EPID)-based IM ... Full text Link to item Cite

Feasibility of Using a Fourier Markerless Technique for Clinical 4D-CBCT Reconstruction

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Incorporating Trade-Off in Knowledge Modeling of Parotid Dose Sparing in Head and Neck IMRT

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Quality Evaluation of an Automatic VMAT Planning Method for Head-and-Neck Cancer Cases

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Effects of PET Reconstruction Parameters on Region-of-Interest Contouring by SUV Threshold

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Modeling Organs at Risk Dose Sparing in Head and Neck Tomotherapy and IMRT Plans: A Comparison Study

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Normal Tissue Toxicity Criteria in Radiation Therapy

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Quantitative Comparison of Knowledge-Guided IMRT Planning to Expert Planning for Prostate Cancer

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Intertechnique and Interinstitutional Modeling of the Dosimetry of Organs-at-Risk in Head and Neck IMRT Plans

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Single institution's dosimetry and IGRT analysis of prostate SBRT.

Journal Article Radiat Oncol · September 13, 2013 BACKGROUND AND PURPOSE: To report single institution's IGRT and dosimetry analysis on the 37 Gy/5 fraction prostate SBRT clinical trial. MATERIALS/METHODS: The IRB (Duke University Medical Center) approved clinical trial has treated 28 patients with stage ... Full text Link to item Cite

A knowledge-based approach to improving and homogenizing intensity modulated radiation therapy planning quality among treatment centers: an example application to prostate cancer planning.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2013 Featured Publication PURPOSE: Intensity modulated radiation therapy (IMRT) treatment planning can have wide variation among different treatment centers. We propose a system to leverage the IMRT planning experience of larger institutions to automatically create high-quality pla ... Full text Link to item Cite

Adaptive stereotactic body radiation therapy planning for lung cancer.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2013 Featured Publication PURPOSE: To investigate the dosimetric effects of adaptive planning on lung stereotactic body radiation therapy (SBRT). METHODS AND MATERIALS: Forty of 66 consecutive lung SBRT patients were selected for a retrospective adaptive planning study. CBCT images ... Full text Link to item Cite

In reply to Kumar et al.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2013 Full text Link to item Cite

Radiotherapy and radiosurgery for tumors of the central nervous system.

Journal Article Surg Oncol Clin N Am · July 2013 Featured Publication In this article, the application of radiotherapy, alone and in combination with surgery and chemotherapy, in the treatment of metastases to the brain (the most common malignant brain lesion), primary malignant gliomas (the most common malignant primary bra ... Full text Link to item Cite

Respiration-phase-matched digital tomosynthesis imaging for moving target verification: a feasibility study.

Journal Article Med Phys · July 2013 PURPOSE: To develop a respiration-phase-matched digital tomosynthesis (DTS) technique to monitor moving targets, and to evaluate its accuracy for various imaging parameters and anatomical characteristics. METHODS: Previously developed 3D-DTS techniques, re ... Full text Link to item Cite

SU-E-T-143: Dosimetric Characteristics of TrueBeam STx System with High Definition Multi-Leaf Collimator: Commissioning of Stereotactic Radiosurgery.

Journal Article Med Phys · June 2013 IntroductionDosimetric characteristics of one TrueBeam STx treatment unit with a 120-leaf high definition multileaf collimator (HD120MLC) are systematically measured for commissioning of stereotactic radiosurgery (SRS). Due to limited data available, it is ... Full text Link to item Cite

SU-E-T-196: Pretreatment Patient Clinical Objective IMRT Quality Assurance Using a 3D Diode Array.

Conference Med Phys · June 2013 PURPOSE: To evaluate the accuracy and sensitivity of a patient clinical objective IMRT QA tool using a 3D diode array. METHODS: A 3D QA device (Delta4, Scandidos Inc.) with 2 orthogonal diode array planes was used for IMRT QA. The diode spacing is 5mm in c ... Full text Link to item Cite

WE-G-108-08: A Novel Technique for VMAT QA with EPID in Cine Mode On Varian TrueBeam.

Conference Med Phys · June 2013 PURPOSE: Volumetric modulated arc therapy (VMAT) is a relatively new treatment modality for dynamic photon radiation therapy. Pre-treatment quality assurance (QA) is necessary and many efforts have been taken to apply electronic portal imaging device (EPID ... Full text Link to item Cite

TU-G-134-01: 4D-MRI Using Body Area as Internal Respiratory Surrogate: Initial Patient Results.

Journal Article Med Phys · June 2013 PURPOSE: We have previously developed a novel 4D-MRI technique using body area (BA) as internal respiratory surrogate. This study is to demonstrate our initial patient results via validating the accuracy of tumor motion measurements and the improvement of ... Full text Link to item Cite

TH-C-141-07: T2-Weighted 4D-MRI with Combined Phase and Amplitude Sorting.

Journal Article Med Phys · June 2013 PURPOSE: T2-weighted MR provides excellent delineation of malignant liver lesions due to its superior tumor-to-tissue contrast. This study aims to develop a novel T2-weighted retrospective 4D-MRI technique for imaging organ/tumor respiratory motion with im ... Full text Link to item Cite

WE-C-116-07: Tumor Enhancement Using Deformable Image Registration for Four-Dimensional Magnetic Resonance Imaging (4D-MRI): A Feasibility Study.

Journal Article Med Phys · June 2013 PURPOSE: We have previously developed a 4D-MRI technique using the fast imaging sequence employing steady-state acquisition (FIESTA) sequence, which has suboptimal tumor-to-tissue contrast-to-noise ratio (CNR) due to its T2*/T1 weighting. This study invest ... Full text Link to item Cite

WE-G-134-04: Four-Dimensional Dual Cone-Beam CT (4D-DCBCT): Preliminary Experimental Results.

Journal Article Med Phys · June 2013 PURPOSE: One of the major challenges for clinical implementation of 4D-CBCT is long scan time. This study aims to develop a 4D-DCBCT technique to improve the efficiency of 4D imaging (for motion management in radiation therapy). METHODS: A bench-top DCBCT ... Full text Link to item Cite

WE-A-500-01: Quality Control of Lung SBRT: Minimizing Uncertainties From Simulation to Treatment.

Journal Article Med Phys · June 2013 Stringent quality control is critical to the success of lung SBRT. However, uncertainties exist in each step of the lung SBRT procedure. Characterization of organ motion using 4DCT may not present true tumor motion excursion due to its low temporal resolut ... Full text Link to item Cite

MO-F-WAB-11: Investigation of CBCT-Based Patient Positioning Accuracy in Lung SBRT: Correlation with Breathing Irregularity.

Conference Med Phys · June 2013 PURPOSE: To evaluate breathing irregularity induced error in CBCT-based patient positioning in lung SBRT and correlate the error with a measure of breathing variability. METHODS: The 4D extended cardiac-torso (XCAT) digital phantom was used to generate 10- ... Full text Link to item Cite

SU-E-T-560: A Method to Determine Optimal Dynamic MLC Parameters for Varian Truebeam with Millennium MLC and HDMLC.

Conference Med Phys · June 2013 PURPOSE: Correct MLC modeling is essential to the accurate IMRT delivery. Most TPSs use simplified models with parameters of leaf transmission (LT) and dynamic leaf gap (DLG). The common way to determine them is through extrapolation from measurements. In ... Full text Link to item Cite

WE-A-134-04: Comprehensive Evaluation of a Respiration-Phase-Matched Digital Tomosynthesis (DTS) Imaging Technique for Monitoring Moving Targets.

Conference Med Phys · June 2013 PURPOSE: To develop a respiration-phase-matched DTS technique to monitor moving targets, and to evaluate its accuracy for various imaging parameters and anatomical characteristics Methods: Conventional methods, registering on-board DTS(OB-DTS, reconstructe ... Full text Link to item Cite

TU-G-141-03: An On-Board 4D-CBCT Reconstruction Technique Using Limited-Angle Projections Based On Motion Modeling and Free-Form Deformation (MM-FD).

Conference Med Phys · June 2013 PURPOSE: To develop an on-board 4D-CBCT(OB-4D-CBCT) reconstruction technique using prior information and limited-angle projections for 4D inter/intra-fractional target verificationMethods: The OB-4D-CBCT at each phase is considered as a deformation of plan ... Full text Link to item Cite

SU-E-T-602: Dynamic Electron Arc Radiotherapy (DEAR): A Planning Study.

Conference Med Phys · June 2013 PURPOSE: Electron beam therapy is under-utilized in radiation treatment of cancer and has remained practically unchanged for decades. We propose a new technique, Dynamic Electron Arc Radiotherapy (DEAR) with synchronized couch motion. In DEAR, gantry rotat ... Full text Link to item Cite

TH-C-137-11: Dose-Guided Automatic IMRT Planning: A Feasibility Study.

Journal Article Med Phys · June 2013 PURPOSE: To develop and evaluate an automatic planning technique for prostate cancer utilizing prior expert plan's dose as guidance. METHODS: A plan atlas was created using 10 expert prostate IMRT plans covering a variety of typical anatomical configuratio ... Full text Link to item Cite

SU-D-500-06: On-Board Robotic Multi-Pinhole SPECT System for Prone Breast Imaging.

Journal Article Med Phys · June 2013 PURPOSE: To investigate a novel Single Photon Emission Computed Tomography (SPECT) system for on-board molecular and functional imaging in partial breast radiation therapy of prone patients. METHODS: Computer-simulation studies were performed for on-board ... Full text Link to item Cite

Spiral computed tomography phase-space source model in the BEAMnrc/EGSnrc Monte Carlo system: implementation and validation.

Journal Article Phys Med Biol · April 21, 2013 Featured Publication Currently, the BEAMnrc/EGSnrc Monte Carlo (MC) system does not provide a spiral CT source model for the simulation of spiral CT scanning. We developed and validated a spiral CT phase-space source model in the BEAMnrc/EGSnrc system. The spiral phase-space s ... Full text Link to item Cite

Quality requirements for stereotactic body radiation therapy (SBRT) in multi-institutional clinical trials

Journal Article IFMBE Proceedings · April 16, 2013 Featured Publication Clinical evidence have shown SBRT to be a tolerable, efficacious, and promising non-invasive therapy. Randomized prospective studies comparing surgery vs. SBRT in early-stage lung cancer are proposed to further investigate the relative survival, quality of ... Full text Cite

Quantification and minimization of uncertainties of internal target volume for stereotactic body radiation therapy of lung cancer.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2013 Featured Publication PURPOSE: To quantify uncertainties in delineating an internal target volume (ITV) and to understand how these uncertainties may be individually minimized for stereotactic body radiation therapy (SBRT) of early stage non-small cell lung cancer (NSCLC). METH ... Full text Link to item Cite

A dual cone-beam CT system for image guided radiotherapy: initial performance characterization.

Journal Article Med Phys · February 2013 Featured Publication PURPOSE: The purpose of this study is to evaluate the performance of a recently developed benchtop dual cone-beam computed tomography (CBCT) system with two orthogonally placed tube∕detector sets. METHODS: The benchtop dual CBCT system consists of two orth ... Full text Link to item Cite

Investigation of sliced body volume (SBV) as respiratory surrogate.

Journal Article J Appl Clin Med Phys · January 7, 2013 Featured Publication The purpose of this study was to evaluate the sliced body volume (SBV) as a respiratory surrogate by comparing with the real-time position management (RPM) in phantom and patient cases. Using the SBV surrogate, breathing signals were extracted from unsorte ... Full text Open Access Link to item Cite

Improving Tumor-to-Tissue CNR of 4D-MRI Using Deformable Image Registration.

Journal Article Pract Radiat Oncol · 2013 Full text Link to item Cite

Phase/Amplitude-matched Digital Tomosynthesis (DTS) Imaging for Moving Target Localization.

Conference Pract Radiat Oncol · 2013 Full text Link to item Cite

TH‐A‐WAB‐04: Respiratory Sorted Imaging Using Region‐Of‐Interest Robotic Multi‐Pinhole SPECT System

Conference Medical Physics · January 1, 2013 Purpose: Single Photon Emission Computed Tomography (SPECT) may provide important information on tumors in the thorax and abdomen. Respiratory sorted imaging using conventional full cross‐section methods is generally degraded by noise. The purpose is to in ... Full text Cite

WE‐G‐500‐09: Robotic Multi‐Pinhole Scenarios for SPECT Molecular and Functional Imaging Onboard and in Other Applications

Conference Medical Physics · January 1, 2013 Purpose: Single Photon Emission Computed Tomography (SPECT) is one of the two predominant modes of nuclear emission tomography, the other being Positron Emission Tomography (PET). An important recent advance has been region‐of‐interest (ROI) SPECT for card ... Full text Cite

SU‐E‐J‐200: Impact of FDG‐PET/CT Reconstruction Parameters On PET Variability and Treatment Response Assessment

Conference Medical Physics · January 1, 2013 Purpose: To examine the effect of PET image reconstruction parameters on baseline and early‐treatment FDG‐PET/CT quantitative imaging. Early‐treatment changes in tumor metabolism in primary tumor and nodes can potentially determine if the patient is respon ... Full text Cite

SU‐E‐T‐474: Adaptive Stereotactic Body Radiation Therapy (SBRT) Planning for Lung Cancer: Can We Predict Who Will Benefit?

Conference Medical Physics · January 1, 2013 Purpose: We have previously shown that adaptive lung SBRT planning can mitigate dose to adjacent organs at risk (OARs). The aim of this study is to investigate factors that affect dosimetric effectiveness of adaptive lung SBRT, so that we may predict which ... Full text Cite

TU‐C‐141‐08: Evaluate Deformable Image Registration for the Lungs Using Hyperpolarized Gas Tagging MRI

Conference Medical Physics · January 1, 2013 Purpose: To evaluate deformable image registration for the lungs using hyperpolarized gas MR tagging technique.Method and Materials: A 3D MR grid‐tagging technique using hyperpolarized helium‐3 (HP‐He3) as gaseous contrast was developed for direct measurem ... Full text Cite

SU‐E‐J‐150: Investigation of Feasibility of Concurrent Orthogonal KV and MV X‐Ray Imaging for Tagrget Tracking During Dose Delivery for Stereotactic Body Radiotherapy (SBRT): A Pilot Phantom Study

Conference Medical Physics · January 1, 2013 Purpose: To investigate feasibility of motion tracking using concurrent orthogonal kV and MV x‐ray images acquired during dose delivery for stereotactic body radiotherapy (SBRT).Method and Materials: The study was performed on a Varian TrueBeam treatment u ... Full text Cite

SU‐E‐CAMPUS‐J‐04: Evaluating Radiation‐Induced Changes with Diffusion Weighted MRI and Dynamic Contrast Enhanced MRI in Patients with Early Stage Breast Cancer Treated with Stereotactic Body Radiotherapy: Initial Results

Conference Medical Physics · January 1, 2013 Purpose: Pre‐operative stereotactic body radiosurgery (SBRT) was delivered in a single fraction to treat patients with early stage breast cancer; however, few data are available regarding radiation‐induced changes by SBRT. In this work, diffusion weighted ... Full text Cite

SU‐E‐T‐707: Evaluation of the Quality of Organs‐At‐Risk Dose Sparing in Anorectal and Prostate IMRT Plans

Conference Medical Physics · January 1, 2013 Purpose: To evaluate the quality of organs‐at‐risk (OARs) dose sparing in IMRT plans for anorectal and prostate cancer cases utilizing organ‐based knowledge models to predict OAR DVHs.MethodsThe quality of OAR dose sparing in IMRT plans are evaluated by or ... Full text Cite

TH‐C‐137‐08: Dosimetric Quality of An Automatic IMRT Planning Method for Head and Neck Cancer Cases

Conference Medical Physics · January 1, 2013 Purpose: To evaluate the dosimetric quality of an automatic IMRT planning method for Head and Neck (HN) cancer cases. Methods: Eighteen HN cancer patients are planned with nine equally spaced IMRT beams. The OAR dose sparing objectives for each plan (prima ... Full text Cite

SU‐E‐CAMPUS‐T‐05: Quality Evaluation of An Automatic VMAT Planning Method for Head and Neck Cancer Cases

Conference Medical Physics · January 1, 2013 Purpose: To evaluate the dosimetric quality of an automatic volumetric‐modulated arc therapy (VMAT) planning method for Head and Neck (HN) cancer cases. Methods: Eighteen HN cancer cases are planned automatically by 2‐arc VMAT. An OAR DVH prediction model ... Full text Cite

TU‐E‐108‐02: Dynamic Electron Arc Radiotherapy (DEAR): A Feasibility Study

Conference Medical Physics · January 1, 2013 Purpose: Electron beam therapy is under‐utilized in radiation treatment of cancer and has remained practically unchanged for decades. We propose a new technique, Dynamic Electron Arc Radiotherapy (DEAR) with synchronized couch motion. DEAR utilizes modulat ... Full text Cite

SU‐E‐J‐91: Developing Platform for Online Registration Using Digital Tomosynthesis

Conference Medical Physics · January 1, 2013 Purpose: To meet the needs of fast registration of on‐board digital tomosynthesis (DTS), a platform was developed in assisting the task of intensive DTS reconstruction and analysis. Methods: this platform consists of four parts: pre‐processing, reconstruct ... Full text Cite

Implementation of remote 3-dimensional image guided radiation therapy quality assurance for radiation therapy oncology group clinical trials.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2013 Featured Publication PURPOSE: To report the process and initial experience of remote credentialing of three-dimensional (3D) image guided radiation therapy (IGRT) as part of the quality assurance (QA) of submitted data for Radiation Therapy Oncology Group (RTOG) clinical trial ... Full text Link to item Cite

Investigation of sliced body volume (SBV) as respiratory surrogate

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2013 Featured Publication The purpose of this study was to evaluate the sliced body volume (SBV) as a respiratory surrogate by comparing with the real-time position management (RPM) in phantom and patient cases. Using the SBV surrogate, breathing signals were extracted from unsorte ... Full text Cite

Implementing and integrating a clinically driven electronic medical record for radiation oncology in a large medical enterprise.

Journal Article Front Oncol · 2013 PURPOSE/OBJECTIVE: While our department is heavily invested in computer-based treatment planning, we historically relied on paper-based charts for management of Radiation Oncology patients. In early 2009, we initiated the process of conversion to an electr ... Full text Link to item Cite

The effect of motion on IMRT - looking at interplay with 3D measurements.

Conference J Phys Conf Ser · 2013 Six base of skull IMRT treatment plans were delivered to 3D dosimeters within the RPC Head and Neck Phantom for QA verification. Isotropic 2mm 3D data was obtained using the DLOS-PRESAGE system and compared to an Eclipse (Varian) treatment plan. Normalized ... Full text Link to item Cite

Interleaved acquisition for cross scatter avoidance in dual cone-beam CT.

Journal Article Med Phys · December 2012 Featured Publication PURPOSE: Cone-beam x-ray imaging with flat panel detectors is used for target localization in image guided radiation therapy. This imaging includes cone-beam computed tomography (CBCT) and planar imaging. Use of two orthogonal x-ray systems could reduce im ... Full text Link to item Cite

Generation of Virtual Monochromatic (VM) CBCT from Dual kV/MV Beam Projections

Conference International Journal of Radiation Oncology*Biology*Physics · November 2012 Full text Cite

Functional and Molecular Imaging of the Axilla as the Patient Is in Position for Radiation Therapy Using a Robotic Multi-pinhole SPECT System

Conference International Journal of Radiation Oncology*Biology*Physics · November 2012 Full text Cite

Commissioning and dosimetric characteristics of TrueBeam system: composite data of three TrueBeam machines.

Journal Article Med Phys · November 2012 Featured Publication PURPOSE: A TrueBeam linear accelerator (TB-LINAC) is designed to deliver traditionally flattened and flattening-filter-free (FFF) beams. Although it has been widely adopted in many clinics for patient treatment, limited information is available related to ... Full text Link to item Cite

Quantitative analysis of the factors which affect the interpatient organ-at-risk dose sparing variation in IMRT plans.

Journal Article Med Phys · November 2012 Featured Publication PURPOSE: The authors present an evidence-based approach to quantify the effects of an array of patient anatomical features of the planning target volumes (PTVs) and organs-at-risk (OARs) and their spatial relationships on the interpatient OAR dose sparing ... Full text Link to item Cite

Stereotactic body radiotherapy treatment of extracranial metastases.

Journal Article Nat Rev Clin Oncol · November 2012 Featured Publication Radiotherapy is an integral treatment for patients with metastatic cancer, although it is usually reserved for palliation of pain, dyspnoea, oedema, bleeding and neurological symptoms. However, the administration of high-precision radiotherapy, termed ster ... Full text Link to item Cite

Reproducibility of tumor motion probability distribution function in stereotactic body radiation therapy of lung cancer.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2012 Featured Publication PURPOSE: To evaluate the reproducibility of tumor motion probability distribution function (PDF) in stereotactic body radiation therapy (SBRT) of lung cancer using cine megavoltage (MV) images. METHODS AND MATERIALS: Cine MV images of 20 patients acquired ... Full text Link to item Cite

Dosimetric Evaluation of Flattening Filter-free (FFF) Photon Beams for Lung SBRT

Conference International Journal of Radiation Oncology*Biology*Physics · November 2012 Full text Cite

Impact of Patient Anatomy Variations on a Fourier Technique for Markerless 4D-CBCT

Conference International Journal of Radiation Oncology*Biology*Physics · November 2012 Full text Cite

Prostate SBRT in 5 Fractions: Initial Report on Dosimetric Results and IGRT Experiences

Conference International Journal of Radiation Oncology*Biology*Physics · November 2012 Full text Cite

Knowledge-based Organ-at-Risk Sparing Models and Individualized Trade-offs in Intensity Modulated Radiation Therapy Planning

Conference International Journal of Radiation Oncology*Biology*Physics · November 2012 Full text Cite

Can Standard Radiation Therapy Quality Assurance (QA) Detect Potential Delivery Errors?

Conference International Journal of Radiation Oncology*Biology*Physics · November 2012 Full text Cite

Evaluation of IMRT and VMAT for Head-and-Neck Cancer With Flattening Filter-free (FFF) Beams

Conference International Journal of Radiation Oncology*Biology*Physics · November 2012 Full text Cite

Partial Breast Extracranial Radiosurgery: A Dosimetric Evaluation of Treatment Delivery Accuracy

Conference International Journal of Radiation Oncology*Biology*Physics · November 2012 Full text Cite

Implementation of dual-energy technique for virtual monochromatic and linearly mixed CBCTs.

Journal Article Med Phys · October 2012 Featured Publication PURPOSE: To implement dual-energy imaging technique for virtual monochromatic (VM) and linearly mixed (LM) cone beam CTs (CBCTs) and to demonstrate their potential applications in metal artifact reduction and contrast enhancement in image-guided radiation ... Full text Link to item Cite

Feasibility study of a synchronized-moving-grid (SMOG) system to improve image quality in cone-beam computed tomography (CBCT).

Journal Article Med Phys · August 2012 Featured Publication PURPOSE: To evaluate the feasibility of a synchronized moving grid (SMOG) system to remove scatter artifacts, improve the contrast-to-noise ratio (CNR), and reduce image lag artifacts in cone-beam CT (CBCT). METHODS: The SMOG system proposed here uses a ra ... Full text Link to item Cite

Imaging system QA of a medical accelerator, Novalis Tx, for IGRT per TG 142: our 1 year experience.

Journal Article J Appl Clin Med Phys · July 5, 2012 Featured Publication American Association of Physicists in Medicine (AAPM) task group (TG) 142 has recently published a report to update recommendations of the AAPM TG 40 report and add new recommendations concerning medical accelerators in the era of image-guided radiation th ... Full text Open Access Link to item Cite

SU-E-J-209: A Simple Method to Minimize Uncertainty in ITV Delineation: Phantom Verification.

Journal Article Med Phys · June 2012 PURPOSE: Irregular breathing causes variation in delineation of internal target volume (ITV), which is typically generated in the maximum intensity projection (MIP) images [1]. Previous studies have shown that MIP-based ITV can underestimate true tumor ran ... Full text Link to item Cite

SU-E-J-145: Implementing 4D XCAT Phantom for 4D Radiotherapy Research.

Journal Article Med Phys · June 2012 PURPOSE: To characterize and implement the 4D Integrated Extended Cardiac Torso (XCAT) digital phantom for 4D radiotherapy (RT) application. METHODS: A computer program was developed to facilitate the characterization and implementation of the 4D XCAT phan ... Full text Link to item Cite

TU-E-BRB-04: Adaptive Stereotactic-Body Radiation Therapy (SBRT) Planning for Lung Cancer.

Journal Article Med Phys · June 2012 PURPOSE: Tumor shrinkage during lung SBRT has been reported. Adaptive SBRT planning can potentially escalate dose to the target and mitigate dose to surrounding tissues. In this study, we investigated dosimetric effects of adaptive lung SBRT planning using ... Full text Link to item Cite

MO-A-213AB-04: Verification of 4D Dose Delivery Using 4D Digital Human Phantom.

Journal Article Med Phys · June 2012 PURPOSE: At present, techniques of 4D dose verification in radiation therapy for lung cancers associated with respiratory motion are very limited, due to either lack of patient anatomy or breathing information. The aim of this study is to develop a 4D dose ... Full text Link to item Cite

SU-D-218-02: 4D-MRI Based on Body Area (BA) Surrogate and Sagittal Image Acquisition.

Journal Article Med Phys · June 2012 PURPOSE: 4D-MRI based on body area (BA) surrogate using axial image acquisition has been demonstrated. Since respiratory motion mostly occurs in the superior-inferior (SI) direction, it is expected that sagittal acquisition may provide more robust and accu ... Full text Link to item Cite

SU-E-J-32: Evaluation of the Dosimetric Accuracy of Stereotactic Radiosurgery with Cone-Beam Computed Tomography Localization.

Journal Article Med Phys · June 2012 PURPOSE: To evaluate the dosimetric accuracy of stereotactic radiosurgery (SRS) with cone-beam computed tomography (CBCT) guided patient localization. METHODS: A Novalis TX linear accelerator with high definition multileaf collimator (HDMLC) was used for S ... Full text Link to item Cite

SU-E-T-104: Commissioning and Dosimetric Characteristics of TrueBeam System: Composite Data of Three TrueBeam Machines.

Journal Article Med Phys · June 2012 INTRODUCTION: A TrueBeam linear accelerator (TB-LINAC) is designed to deliver standard flattened and flattening-filter-free (FFF) beams. In our institute, three TB-LINAC units are installed. In this work, composite data of the three units and multi-unit co ... Full text Link to item Cite

MO-D-BRB-09: Treatment Delivery QA for Online Adaptive Radiation Therapy Based on Dynamic Machine Information (DMI): A Feasibility Study.

Journal Article Med Phys · June 2012 PURPOSE: To implement a quality assurance (QA) system for the treatment delivery of online adaptive radiation therapy utilizing Dynamic Machine Information (DMI). MATERIALS AND METHODS: DMI provides the expected/actual MLC leaf-positions, delivered MU, and ... Full text Link to item Cite

SU-E-T-559: Evaluation of Flatening Filter Free (FFF) Beams in Radiotherapy of Head and Neck Cancer.

Journal Article Med Phys · June 2012 PURPOSE: To investigate th applicability of the flattening filter free (FFF) to fractionated radiotherapy of head and neck cancer. METHODS: Twelve patients previously treated with IMRT were selected. A SIB protocol was chosen so that 66/54 Gy were prescrib ... Full text Link to item Cite

Stereotactic radiotherapy for malignancies involving the trigeminal and facial nerves.

Journal Article Technol Cancer Res Treat · June 2012 Featured Publication Involvement of a cranial nerve caries a poor prognosis for many malignancies. Recurrent or residual disease in the trigeminal or facial nerve after primary therapy poses a challenge due to the location of the nerve in the skull base, the proximity to the b ... Full text Link to item Cite

SU-E-T-406: Online Image-Guidance for Prostate SBRT: Dosimetric Benefits and Margin Analysis.

Conference Med Phys · June 2012 PURPOSE: To evaluate the dosimetric benefits of online image guidance during prostate stereotactic body radiotherapy (SBRT) and the potential on margin reduction. METHODS: 28 prostate SBRT patients were retrospectively studied, each treated with 37Gy in 5 ... Full text Link to item Cite

SU-E-T-626: Individualized Trade-Off of Dose Coverage and Sparing in IMRT Planning.

Conference Med Phys · June 2012 PURPOSE: We present an evidence-based approach to quantifying the dose sparing trade-offs between different Organs-at-risk (OARs) and the trade-off between OAR dose sparing and target dose coverage in IMRT plans. METHODS: The interaction between dose spari ... Full text Link to item Cite

MO-D-BRB-10: Modeling Inter-Patient Variation of Organ-At-Risk Sparing in IMRT Plans: An Evidence-Based Plan Quality Evaluation.

Conference Med Phys · June 2012 PURPOSE: To develop a predictive model to assess the quality of critical organ dose sparing in IMRT plans by providing patient specific dose sparing references, based on an array of patient anatomical features and prior planning experience. METHODS: Contri ... Full text Link to item Cite

Target localization using scanner-acquired SPECT data.

Journal Article J Appl Clin Med Phys · May 10, 2012 Featured Publication Target localization using single photon emission computed tomography (SPECT) and planar imaging is being investigated for guiding radiation therapy delivery. Previous studies on SPECT-based localization have used computer-simulated or hybrid images with si ... Full text Open Access Link to item Cite

Dosimetric comparison of treatment plans based on free breathing, maximum, and average intensity projection CTs for lung cancer SBRT.

Journal Article Med Phys · May 2012 Featured Publication PURPOSE: To determine whether there is a CT dataset may be more favorable for planning and dose calculation by comparing dosimetric characteristics between treatment plans calculated using free breathing (FB), maximum and average intensity projection (MIP ... Full text Link to item Cite

Comparison of 3D conformal breast radiation treatment plans using the anisotropic analytical algorithm and pencil beam convolution algorithm.

Journal Article Radiother Oncol · May 2012 Featured Publication PURPOSE: To investigate (1) dosimetric differences between plans calculated using the anisotropic analytical algorithm (AAA) and pencil beam convolution (PBC) algorithm, (2) the plan quality achieved using AAA compared to PBC based on dosimetric parameters ... Full text Link to item Cite

Volumetric-modulated arc therapy: effective and efficient end-to-end patient-specific quality assurance.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2012 Featured Publication PURPOSE: To explore an effective and efficient end-to-end patient-specific quality-assurance (QA) protocol for volumetric modulated arc radiotherapy (VMAT) and to evaluate the suitability of a stationary radiotherapy QA device (two-dimensional [2D] ion cha ... Full text Link to item Cite

Development and clinical evaluation of a three-dimensional cone-beam computed tomography estimation method using a deformation field map.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2012 Featured Publication PURPOSE: To develop a three-dimensional (3D) cone-beam computed tomography (CBCT) estimation method using a deformation field map, and to evaluate and optimize the efficiency and accuracy of the method for use in the clinical setting. METHODS AND MATERIALS ... Full text Link to item Cite

Accelerating phase contrast MR angiography by simplified skipped phase encoding and edge deghosting with array coil enhancement.

Journal Article Med Phys · March 2012 Featured Publication PURPOSE: The aim of this work is to investigate the feasibility of accelerating phase contrast magnetic resonance angiography (PC-MRA) by the fast imaging method of simplified skipped phase encoding and edge deghosting with array coil enhancement (S-SPEED- ... Full text Link to item Cite

A novel technique for markerless, self-sorted 4D-CBCT: feasibility study.

Journal Article Med Phys · March 2012 Featured Publication PURPOSE: Four-dimensional CBCT (4D-CBCT) imaging in the treatment room can provide verification of moving targets, facilitating the potential for margin reduction and consequent dose escalation. Reconstruction of 4D-CBCT images requires correlation of resp ... Full text Link to item Cite

On-Board Digital Tomosynthesis: An Emerging New Technology for IGRT

Chapter · February 22, 2012 Cite

Lipiodol: a potential direct surrogate for cone-beam computed tomography image guidance in radiotherapy of liver tumor.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2012 Featured Publication PURPOSE: To investigate the feasibility of using lipiodol as a direct surrogate for target localization using cone-beam CT (CBCT) image guidance in radiotherapy (RT) of patients with unresectable liver tumors after transarterial chemoembolization. METHODS ... Full text Link to item Cite

DOSE DEPENDENCE OF RADIATION-INDUCED ERECTILE DYSFUNCTION IN AN ANIMAL MODEL

Journal Article JOURNAL OF SEXUAL MEDICINE · February 1, 2012 Link to item Cite

Assessing Effects of Ion Collection Efficiency in Flattening Filter-Free (FFF) Beams On Three TrueBeam Machines

Conference MEDICAL PHYSICS · 2012 Full text Cite

TU‐A‐213CD‐04: A Novel Technique for Estimating and Correcting Cross‐Scatter in Dual‐Source CBCT

Conference Medical Physics · January 1, 2012 Purpose: Dual‐source CBCT may provide several advantages over current on‐board 3D localization techniques; however, dual‐source CBCT suffers greatly from cross‐scatter. A novel technique was developed that includes sampling the cross‐scatter only projectio ... Full text Cite

Dual-Energy CBCT Imaging for Metal Artifact Reduction and Contrast Enhancement

Conference MEDICAL PHYSICS · 2012 Full text Cite

TH‐E‐BRA‐01: A Line‐Source Method for Aligning Onboard‐Robotic‐Pinhole and Other SPECT‐Pinhole Systems

Conference Medical Physics · January 1, 2012 Purpose: To achieve on‐board molecular imaging in the radiation therapy room, we are developing a robotic multi‐pinhole SPECT system. Alignment of the SPECT system to LINAC/CBCT coordinates is essential for target localization and image reconstruction. Pin ... Full text Cite

TU‐A‐BRA‐01: A Robotic Multi‐Pinhole SPECT System for Onboard and Other Region‐Of‐Interest Imaging

Conference Medical Physics · January 1, 2012 Purpose: Radiation therapy beam guidance and modulation at treatment time could be substantially supported by onboard molecular and functional imaging capability. Currently there is very little range of technology available for this. Herein we propose and ... Full text Cite

A Fourier Technique for Markerless, Self-Sorted 4D-CBCT: Effect of Respiratory Characteristics

Conference MEDICAL PHYSICS · 2012 Full text Cite

Evaluating Radiation-Induced White Matter Changes in Patients with Recurrent Malignant Gliomas Under Treatment of Stereotactic Radiosurgery Using Diffusion Tensor Imaging

Conference MEDICAL PHYSICS · 2012 Full text Cite

Phase-Matched Digital Tomosynthesis (DTS) Imaging for Simultaneous Target Verification During Volumetric Modulated Arc Therapy (VMAT) Treatment

Conference MEDICAL PHYSICS · 2012 Full text Cite

Benchmarking Flattening-Filter Free Photons for IMRT/VMAT

Conference MEDICAL PHYSICS · 2012 Full text Cite

A Protocol for Comprehensive Acceptance/Commissioning of Complex 3D QA Devices

Conference MEDICAL PHYSICS · 2012 Full text Cite

Experimental Measurements of 3D Dose Distribution for a Moving Target Treated with IMRT and VMAT

Conference MEDICAL PHYSICS · 2012 Full text Cite

Contrast-To-Noise Ratio (CNR) Enhancement and Lag Correction in Cone Beam CT (CBCT) Using a Synchronized-MOving-Grid (SMOG) System

Conference MEDICAL PHYSICS · 2012 Full text Cite

WE‐C‐213CD‐01: Decision Support for Radiation Therapy

Conference Medical Physics · January 1, 2012 Informatics in radiation therapy is less understood. Decision support for, or knowledge‐guided, radiation therapy, is a major component of informatics, where the data is mined, modeled and turned into computable knowledge. It is critically important for ra ... Full text Cite

TH‐C‐BRB‐01: Credentialing Results from a Spine Anthropomorphic Phantom

Conference Medical Physics · January 1, 2012 Purpose: To use an anthropomorphic spine phantom for dosimetric credentialing purposes in National Cancer Institute sponsored clinical trials. Methods: An anthropomorphic spine phantom that consists of lungs, a heart, an esophagus, a spinal cord, vertebrae ... Full text Cite

On-Board Digital Tomosynthesis: An Emerging New Technology for Image-Guided Radiation Therapy

Chapter · January 1, 2012 External-beam radiation therapy is a common treatment modality for cancers. e treatment course typically consists of 30-40 daily fractions of 180-200 cGy over several weeks. On-board imaging (OBI) guidance is oen designed to track shis in patient positioni ... Full text Cite

Imaging system QA of a medical accelerator, Novalis Tx, for IGRT per TG 142: Our 1 year experience

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2012 Featured Publication American Association of Physicists in Medicine (AAPM) task group (TG) 142 has recently published a report to update recommendations of the AAPM TG 40 report and add new recommendations concerning medical accelerators in the era of image-guided radiation th ... Full text Cite

Target localization using scanner-acquired SPECT data

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2012 Featured Publication Target localization using single photon emission computed tomography (SPECT) and planar imaging is being investigated for guiding radiation therapy delivery. Previous studies on SPECT-based localization have used computer-simulated or hybrid images with si ... Full text Cite

Development of a 4D dosimetry simulation system in radiotherapy

Journal Article International Journal of Biomedical Engineering and Technology · January 1, 2012 Featured Publication 4D CT image sets are used to encode patient-organ motion and to calculate the dose delivered during each respiratory phase. The dose-per-phase is summarised to the total dose via deformable registration. The system incorporates the actual beam parameters a ... Full text Cite

Establishing a framework to implement 4D XCAT phantom for 4D radiotherapy research.

Journal Article J Cancer Res Ther · 2012 Featured Publication AIMS: To establish a framework to implement the 4D integrated extended cardiac torso (XCAT) digital phantom for 4D radiotherapy (RT) research. MATERIALS AND METHODS: A computer program was developed to facilitate the characterization and implementation of ... Full text Link to item Cite

Four-dimensional magnetic resonance imaging (4D-MRI) using image-based respiratory surrogate: a feasibility study.

Journal Article Med Phys · December 2011 Featured Publication PURPOSE: Four-dimensional computed tomography (4D-CT) has been widely used in radiation therapy to assess patient-specific breathing motion for determining individual safety margins. However, it has two major drawbacks: low soft-tissue contrast and an exce ... Full text Link to item Cite

RTOG 0631 Phase II/III Study of Image-Guided Stereotactic Radiosurgery for Localized (1-3) Spine Metastases: Phase II Results.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2011 PURPOSE: The phase II component of RTOG 0631 assessed the feasibility and safety of spine radiosurgery (SRS) for localized spine metastases in a cooperative group setting. MATERIALS AND METHODS: Patients with 1-3 spine metastasis with a Numerical Rating Pa ... Full text Link to item Cite

RTOG 0631 Phase II/III Study of Image-guided Stereotactic Radiosurgery for Localized Spine Metastases: Phase II Results

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Contour based respiratory motion analysis for free breathing CT.

Journal Article Comput Biol Med · October 2011 Featured Publication We propose a method to quantify superior-inferior (SI) motion of a rigid target using the 3D contour from free-breathing CT (FBCT). The technique utilizes similarity between 2D contours (Jaccard Index) and a population based density function for probabilit ... Full text Link to item Cite

Fourier Transform (FT) Techniques for Markerless 4D Cone-beam CT (4D-CBCT) Sorting: Comparison between Phase vs. Magnitude

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Correlation between External Surrogate Motion and Lung Tumor Motion: From a Statistical Point of View

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Dosimetric Evaluation and Optimization of a Novel CBCT Estimation Method for Adaptive Radiation Therapy (ART)

Conference International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

A Dual-Isocenter Technique for Image Guidance of Prone-Breast Radiation Therapy

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Radiation-induced erectile dysfunction using prostate-confined modern radiotherapy in a rat model.

Journal Article J Sex Med · August 2011 Featured Publication INTRODUCTION: The mechanisms of radiation-induced erectile dysfunction (ED) are unclear, as clinical studies are limited, and previous animal models were based on wide-field irradiation, which does not model current radiotherapy (RT) techniques. AIMS: To p ... Full text Link to item Cite

Potential underestimation of the internal target volume (ITV) from free-breathing CBCT.

Journal Article Med Phys · August 2011 Featured Publication PURPOSE: Localization prior to delivery of SBRT to free-breathing patients is performed by aligning the planning internal target volume (ITV) from 4DCT with an on-board free-breathing cone-beam CT (FB-CBCT) image. The FB-CBCT image is assumed to also gener ... Full text Link to item Cite

Evaluation of integrated respiratory gating systems on a Novalis Tx system.

Journal Article J Appl Clin Med Phys · April 4, 2011 Featured Publication The purpose of this study was to investigate the accuracy of motion tracking and radiation delivery control of integrated gating systems on a Novalis Tx system. The study was performed on a Novalis Tx system, which is equipped with Varian Real-time Positio ... Full text Open Access Link to item Cite

909 INDUCTION OF RADIATION-INDUCED ERECTILE DYSFUNCTION OF RAT AFTER PROSTATE-CONFINED MODERN RADIOTHERAPY

Conference Journal of Urology · April 2011 Full text Cite

Crescent artifacts in cone-beam CT.

Journal Article Med Phys · April 2011 Featured Publication PURPOSE: In image-guided radiation therapy, cone-beam CT has been adopted for three-dimensional target localization in the treatment room. In many of these cone-beam CT images, dark and light crescent artifacts can be seen. This study investigates potentia ... Full text Link to item Cite

Adaptive prostate IGRT combining online re-optimization and re-positioning: a feasibility study.

Journal Article Phys Med Biol · March 7, 2011 Featured Publication In prostate radiation therapy, inter-fractional organ motion/deformation has posed significant challenges on reliable daily dose delivery. To correct for this issue, off-line re-optimization and online re-positioning have been used clinically. In this pape ... Full text Link to item Cite

A planning quality evaluation tool for prostate adaptive IMRT based on machine learning.

Journal Article Med Phys · February 2011 Featured Publication PURPOSE: To ensure plan quality for adaptive IMRT of the prostate, we developed a quantitative evaluation tool using a machine learning approach. This tool generates dose volume histograms (DVHs) of organs-at-risk (OARs) based on prior plans as a reference ... Full text Link to item Cite

Feasibility study of an intensity-modulated radiation model for the study of erectile dysfunction.

Journal Article J Sex Med · February 2011 Featured Publication INTRODUCTION: Preclinical studies of radiotherapy (RT) induced erectile dysfunction (ED) have been limited by radiation toxicity when using large fields. AIM: To develop a protocol of rat prostate irradiation using techniques mimicking the current clinical ... Full text Link to item Cite

Computed tomography dose index and dose length product for cone-beam CT: Monte Carlo simulations.

Journal Article J Appl Clin Med Phys · January 19, 2011 Featured Publication Dosimetry in kilovoltage cone beam computed tomography (CBCT) is a challenge due to the limitation of physical measurements. To address this, we used a Monte Carlo (MC) method to estimate the CT dose index (CTDI) and the dose length product (DLP) for a com ... Full text Open Access Link to item Cite

WE‐E‐301‐01: Practical Tips for VMAT Implementation

Conference Medical Physics · January 1, 2011 Volumetric modulated arc therapy (VMAT) is an arc‐based dose delivery approach that produces highly conformal dose distributions similar to those generated with static gantry intensity modulated radiation therapy. Like many existing IMRT approaches, this t ... Full text Cite

SU‐E‐T‐98: VMAT Quality Assurance: Improving the Angular Correction Factors for Ion Chamber Arrays

Conference Medical Physics · January 1, 2011 Purpose: Two‐dimensional (2D) detector arrays for QA of volumetric‐modulated‐arc‐therapy (VMAT) plans show angular dependence. An angular correction‐factor‐table (CFs) minimize this effect, but assumes: (1) the response of all ion chambers (IC) is identica ... Full text Cite

SU‐E‐J‐22: Measurement‐Based Cross‐Scatter Correction in Dual Detector Cone‐Beam CT

Conference Medical Physics · January 1, 2011 Purpose: A dual detector cone‐beam CT (CBCT) system could potentially allow for dual energy CBCT and dual‐view DTS. However, image quality in this system is severely degraded by the presence of scatter between the two imaging chains, i.e. cross‐scatter. Th ... Full text Cite

SU‐C‐214‐06: Noise Power Properties of a Dual‐Detector Cone‐Beam CT System

Conference Medical Physics · January 1, 2011 Purpose: Very little information is available for noise properties using a dual‐detector cone‐beam CT (CBCT) system. Geometric misalignment, cross‐scatter, and inhomogeneous detector response are additional concerns in a dual‐detector system. This study ch ... Full text Cite

SU‐E‐J‐180: SPECT‐Based Target Localization: Comparison between Full‐Size and Compact Detectors

Conference Medical Physics · January 1, 2011 Purpose: Single photon emission computed tomography (SPECT) is being investigated for imaging inside radiation therapy (RT) treatment rooms to target tumor biology. Because of the space occupied by RT devices and the size and weight of typical gamma camera ... Full text Cite

TU‐E‐BRC‐08: Investigation of Anatomical Surrogate for 4DCT Imaging

Conference Medical Physics · January 1, 2011 Purpose: Respiratory signal for 4DCT is typically extracted using an external respiratory positioning management device (RPM) which is often inconvenient and time consuming. The efficiency of 4DCT imaging could be substantially improved if anatomical body ... Full text Cite

SU‐E‐I‐29: A Prior Information Based Total‐Variation Digital Tomosynthesis Reconstruction Algorithm

Conference Medical Physics · January 1, 2011 Purpose: To develop a total‐variation (TV) based compressive sensing image reconstruction algorithm using a set of limited‐angle projections by applying a prior image information to enhance the image quality and anatomic information of current Four‐d ... Full text Cite

MO‐D‐214‐01: 4D‐MRI for Radiation Therapy of Moving Tumors

Conference Medical Physics · January 1, 2011 Four‐dimensional computed tomography (4D‐CT) has been widely used in radiation therapy for imaging moving tumors, especially in the thoracic regions. In other body sites such as the abdominal, 4D‐CT is limited due to its intrinsic low soft‐tissue contrast. ... Full text Cite

MO‐D‐BRB‐03: Investigation of the Reproducibility of Probability Distribution function (PDF) of Tumor Motion in Lung Stereotactic Body Radiation Therapy (SBRT)

Conference Medical Physics · January 1, 2011 Purpose: To investigate the reproducibility of probability distribution function (PDF) of lung tumor motion using cine‐MV images from lung SBRT treatments. Findings of the study will provide valuable information for probability‐based treatment planning. Me ... Full text Cite

SU‐E‐T‐123: Evaluation of Integrated Gating Systems on a Novalis Tx System Using Quantitative Motion Tracking Analyses and Efficient Time‐Delay Measurements

Conference Medical Physics · January 1, 2011 Purpose: To investigate accuracy of motion tracking and radiation delivery controlling of integrated gating systems on a Novalis Tx system. Methods: The study was performed on a Novalis Tx system, which is equipped with Varian RPM and BrainLAB ExacTrac gat ... Full text Cite

SU‐F‐BRA‐10: A Novel Technique for Markerless Self‐Sorted 4D‐CBCT

Conference Medical Physics · January 1, 2011 Purpose: Four‐dimensional (4D) imaging in the radiotherapy treatment room can provide verification of moving targets, which allows for potential reduction of margins and consequent dose escalation. 4D‐CBCT acquisition requires correlation between projectio ... Full text Cite

MO‐F‐211‐04: Fast Phase Contrast MR Angiography with Simplified Skipped Phase Encoding and Edge Deghosting with Array Coil Enhancement (S‐ SPEED‐ACE)

Conference Medical Physics · January 1, 2011 Purpose: The aim of this work is to investigate the feasibility of accelerating phase contrast MR angiography by the fast imaging method of Simplified Skipped Phase Encoding and Edge Deghosting with Array Coil Enhancement (S‐SPEED‐ACE). Methods: The parall ... Full text Cite

SU‐E‐T‐99: A Patient Specific QA Protocol for Verification of 4D Dosimetry

Conference Medical Physics · January 1, 2011 Purpose: Presently, there is no patient specific dosimetric QA for radiation treatment of moving targets. Here we present a patient specific QA protocol for verification of 4D dosimetry delivered to a moving target in SBRT of lung and liver tumors. Methods ... Full text Cite

MO‐D‐BRC‐01: Dosimetric Evaluation of a Novel Cone‐Beam CT (CBCT) Estimation Method Using Prior Information for Lung Cancer Patient Treatment

Conference Medical Physics · January 1, 2011 Purpose: To evaluate the dosimetric accuracy of a novel CBCT estimation method using prior information for use in adaptive radiotherapy (ART)‐based treatment of lung cancer patients. Methods: Patient planning CT or previous day's CBCT images are used as th ... Full text Cite

SU‐C‐110‐01: Strategies for Online Plan Re‐Optimization: Objective Settings and Starting Stage

Conference Medical Physics · January 1, 2011 Purpose: To find the most robust strategies of objective setting and starting stage for online plan re‐optimization, so it can be automatically executed within 1 min while providing high quality adaptive plans. Methods: 10 prostate cancer patients, each wi ... Full text Cite

SU‐E‐T‐860: Developing a Fast‐Monotonic Descent (FMD) Algorithm for RapidArc Radiotherapy

Conference Medical Physics · January 1, 2011 Purpose: To develop a fast‐monotonic descent (FMD) algorithm for optimization of VMAT treatment planning, and investigate the impacts of arc numbers and beam interval on the plan dose quality. Methods: Fast‐monotonic descent (FMD) algorithm, proved to be o ... Full text Cite

SU‐E‐T‐854: Key Anatomical Factors Influencing OAR Dose‐Volume Distribution in Prostate IMRT Plans

Conference Medical Physics · January 1, 2011 Purpose: To identify the key factors of patient anatomy that influence the optimal dose volume histograms (DVHs) for the organs‐at‐risk (OARs) and to explore the tradeoffs between different OAR sparing goals. Methods: 88 prostate IMRT plans were studied re ... Full text Cite

TH‐E‐BRB‐05: Modeling the Correlation Between OAR Dose Sparing and Patient's Anatomy in Head and Neck IMRT

Conference Medical Physics · January 1, 2011 Purpose: To summarize the knowledge of the dependence of organ‐at‐risk (OAR) dose‐volume distribution on patient's anatomy by machine learning techniques from a database of previous expert plans. Methods: 35 head‐and‐ neck IMRT plans were studied retrospec ... Full text Cite

Evaluation of motion measurement using cine MRI for image guided stereotactic body radiotherapy on a new phantom platform.

Journal Article J Radiosurg SBRT · 2011 The objective of this study is to investigate accuracy of motion tracking of cine magnetic resonance imaging (MRI) for image-guided stereotactic body radiotherapy. A phantom platform was developed in this work to fulfill the goal. The motion phantom consis ... Link to item Cite

Quality Assurance in Adaptive Radiation Therapy

Chapter · January 1, 2011 To ensure measurement accuracy, it is necessary to generate a comprehensive quality assurance (QA) program. “The ‘quality’ of radiation oncology can be defined as the totality of features or characteristics of the radiation oncology service that bear on it ... Full text Cite

Adaptive radiation therapy: technical components and clinical applications.

Journal Article Cancer J · 2011 Featured Publication In current standard radiation therapy process, patient anatomy is represented by the snapshot of computed tomographic images at the simulation for treatment planning. However, patient anatomy during the treatment course is not static, and the changes can b ... Full text Link to item Cite

Dosimetric comparison of 6 MV and 15 MV single arc rapidarc to helical TomoTherapy for the treatment of pancreatic cancer.

Journal Article Med Dosim · 2011 Featured Publication We conducted a planning study to compare Varian's RapidArc (RA) and helical TomoTherapy (HT) for the treatment of pancreatic cancer. Three intensity-modulated radiotherapy (IMRT) plans were generated for 8 patients with pancreatic cancer: one using HT with ... Full text Link to item Cite

Digital tomosynthesis for respiratory gated liver treatment: clinical feasibility for daily image guidance.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2011 Featured Publication PURPOSE: Breath-hold (BH) treatment minimizes internal target volumes (ITV) when treating sites prone to motion. Digital tomosynthesis (DTS) imaging has advantages over cone-beam CT (CBCT) for BH imaging: BH-DTS scan can be completed during a single breath ... Full text Link to item Cite

Evaluation of integrated respiratory gating systems on a Novalis Tx system

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2011 Featured Publication The purpose of this study was to investigate the accuracy of motion tracking and radiation delivery control of integrated gating systems on a Novalis Tx system. The study was performed on a Novalis Tx system, which is equipped with Varian Real-time Positio ... Full text Cite

Computed tomography dose index and dose length product for cone-beam CT: Monte Carlo simulations of a commercial system

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2011 Featured Publication Dosimetry in kilovoltage cone beam computed tomography (CBCT) is a challenge due to the limitation of physical measurements. To address this, we used a Monte Carlo (MC) method to estimate the CT dose index (CTDI) and the dose length product (DLP) for a com ... Full text Cite

Response to comment on: A planning quality evaluation tool for prostate adaptive IMRT based on machine learning' Med. Phys. 38, 719 (2011)

Journal Article Medical Physics · January 1, 2011 Featured Publication Full text Cite

Apparatus-dependent dosimetric differences in spine stereotactic body radiotherapy.

Journal Article Technol Cancer Res Treat · December 2010 Featured Publication The purpose of this investigation was to study apparatus-dependent dose distribution differences specific to spine stereotactic body radiotherapy (SBRT) treatment planning. This multi-institutional study was performed evaluating an image-guided robotic rad ... Full text Link to item Cite

Regional SPECT imaging using sampling principles and multiple pinholes

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2010 Featured Publication There may be many SPECT imaging applications in which a small region is primarily of interest. One such case is imaging in the radiation therapy treatment room, as the patient is on the treatment table in position for radiation therapy. This onboard imagin ... Full text Cite

Phase Window and Frame Rate Optimization for On-board 4D Imaging Dose Reduction

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Reduced Cross Scatter in Dual-source Cone-Beam CT by Asynchronous Projection Acquisition

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Potentially Underestimating the Internal Target Volume (ITV) in Free-Breathing Cone-Beam CT (CBCT)

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Maximum intensity projection (MIP) imaging using slice-stacking MRIa).

Journal Article Med Phys · November 2010 Featured Publication PURPOSE: To evaluate the feasibility of acquiring maximum intensity projection (MIP) images using a novel slice-stacking MRI (SS-MRI) technique. METHODS: The proposed technique employed a steady state acquisition sequence to image multiple axial slices. At ... Full text Link to item Cite

On-board SPECT for Target Localization: A Comprehensive Analysis of Findings from Computer Simulation and Scanner Studies

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Extracting Breathing Signal from Image Fourier Transform for Developing 4D-MRI

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Cone-Beam CT 6 Degree-of-Freedom Image-Guidance for Intracranial Frameless Stereotactic RadioSurgery using 6D Robotic Couch

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Stereotactic Body Radiotherapy (SBRT) in Patients Previously Treated with External Beam Radiation Therapy

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

A Modern Animal Model of Radiation-induced Erectile Dysfunction

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Intensity Modulated Arc Therapy: Effective and Efficient End-to-end Patient Specific Quality Assurance

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Breast Cancer Radiation Treatment Planning: A Comparison of Anisotropic Analytical Algorithm (AAA) and Pencil Beam Convolution (PBC) Algorithm

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Variation of Clinically Relevant Dose Indices for 3DCRT of Lung with Respect to Dose Calculation Algorithm

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Impact of volumetric modulated arc therapy technique on treatment with partial breast irradiation.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2010 Featured Publication PURPOSE: To investigate the technical feasibility of volumetric modulated arc therapy (V-MAT) in the delivery of partial breast irradiation (PBI). METHODS AND MATERIALS: V-MAT and the standard, three-dimensional conformal radiotherapy (3D-CRT), were compar ... Full text Link to item Cite

Direction-dependent localization errors in SPECT images.

Journal Article Med Phys · September 2010 Featured Publication PURPOSE: Single photon emission computed tomography (SPECT) is being investigated for imaging inside radiation therapy treatment rooms to localize biological targets. Here, computer simulations were used to analyze locational and directional dependencies i ... Full text Link to item Cite

Effects of breathing variation on gating window internal target volume in respiratory gated radiation therapya).

Journal Article Med Phys · August 2010 Featured Publication PURPOSE: To investigate the effects of breathing variation on gating window internal target volume(ITVGW) in respiratory gated radiation therapy. METHOD AND MATERIALS: Two-dimensional dynamic MRI (dMRI) of lung motion was acquired in ten volunteers and eig ... Full text Link to item Cite

Stereotactic body radiation therapy: the report of AAPM Task Group 101.

Journal Article Med Phys · August 2010 Featured Publication Task Group 101 of the AAPM has prepared this report for medical physicists, clinicians, and therapists in order to outline the best practice guidelines for the external-beam radiation therapy technique referred to as stereotactic body radiation therapy (SB ... Full text Link to item Cite

Arc-modulated radiation therapy based on linear models.

Journal Article Phys Med Biol · July 7, 2010 Featured Publication This paper reports an inverse arc-modulated radiation therapy planning technique based on linear models. It is implemented with a two-step procedure. First, fluence maps for 36 fixed-gantry beams are generated using a linear model-based intensity-modulated ... Full text Link to item Cite

Kilovoltage cone-beam CT: comparative dose and image quality evaluations in partial and full-angle scan protocols.

Journal Article Med Phys · July 2010 Featured Publication PURPOSE: To assess imaging dose of partial and full-angle kilovoltage CBCT scan protocols and to evaluate image quality for each protocol. METHODS: The authors obtained the CT dose index (CTDI) of the kilovoltage CBCT protocols in an on-board imager by ion ... Full text Link to item Cite

Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages.

Journal Article FEBS Lett · June 3, 2010 Macrophages play a key role in innate immune response to pathogens and in tissue homeostasis, inflammation and repair. A serpin A3G (SpiA3G) is highly induced in classically activated macrophages. We show increased localization of SpiA3G in the nucleolus a ... Full text Link to item Cite

Estimation of computed tomography dose index in cone beam computed tomography: MOSFET measurements and Monte Carlo simulations.

Journal Article Health Phys · May 2010 Featured Publication To address the lack of accurate dose estimation method in cone beam computed tomography (CBCT), we performed point dose metal oxide semiconductor field-effect transistor (MOSFET) measurements and Monte Carlo (MC) simulations. A Varian On-Board Imager (OBI) ... Full text Link to item Cite

6D image guidance for spinal non-invasive stereotactic body radiation therapy: Comparison between ExacTrac X-ray 6D with kilo-voltage cone-beam CT.

Journal Article Radiother Oncol · April 2010 Featured Publication PURPOSE: To investigate setup discrepancies measured with ExacTrac X-ray 6 degree-of-freedom (6D) and cone-beam computed tomography (CBCT) for patients under treatments of stereotactic body radiation therapy (SBRT). MATERIALS AND METHODS: In this work, pha ... Full text Link to item Cite

Radiotherapy treatment plans with RapidArc for prostate cancer involving seminal vesicles and lymph nodes.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2010 Featured Publication PURPOSE: Dosimetric results and treatment delivery efficiency of RapidArc plans to those of conventional intensity-modulated radiotherapy (IMRT) plans were compared using the Eclipse treatment planning system for high-risk prostate cancer. MATERIALS AND ME ... Full text Link to item Cite

Estimation of absorbed doses from paediatric cone-beam CT scans: MOSFET measurements and Monte Carlo simulations.

Journal Article Radiat Prot Dosimetry · March 2010 Featured Publication The purpose of this study was to establish a dose estimation tool with Monte Carlo (MC) simulations. A 5-y-old paediatric anthropomorphic phantom was computed tomography (CT) scanned to create a voxelised phantom and used as an input for the abdominal cone ... Full text Link to item Cite

Accelerating non-contrast-enhanced MR angiography with inflow inversion recovery imaging by skipped phase encoding and edge deghosting (SPEED).

Journal Article J Magn Reson Imaging · March 2010 Featured Publication PURPOSE: To accelerate non-contrast-enhanced MR angiography (MRA) with inflow inversion recovery (IFIR) with a fast imaging method, Skipped Phase Encoding and Edge Deghosting (SPEED). MATERIALS AND METHODS: IFIR imaging uses a preparatory inversion pulse t ... Full text Link to item Cite

Point/counterpoint. The traditional L-shaped gantry for radiotherapy linear accelerators will soon become obsolete.

Journal Article Med Phys · February 2010 Featured Publication Full text Link to item Cite

Slow gantry rotation acquisition technique for on-board four-dimensional digital tomosynthesis.

Journal Article Med Phys · February 2010 Featured Publication PURPOSE: Four-dimensional cone-beam computed tomography (4D CBCT) has been investigated for motion imaging in the radiotherapy treatment room. The drawbacks of 4D CBCT are long scan times and high imaging doses. The aims of this study were to develop and i ... Full text Link to item Cite

A methodology for selecting the beam arrangement to reduce the intensity-modulated radiation therapy (IMRT) dose to the SPECT-defined functioning lung.

Journal Article Phys Med Biol · January 21, 2010 Featured Publication Macroaggregated albumin single-photon emission computed tomography (MAA-SPECT) provides a map of the spatial distribution of lung perfusion. Our previous work developed a methodology to use SPECT guidance to reduce the dose to the functional lung in IMRT p ... Full text Link to item Cite

Similarities between static and rotational intensity-modulated plans.

Journal Article Phys Med Biol · January 7, 2010 Featured Publication The aim of this study was to explore similarities between intensity-modulated radiotherapy (IMRT) and intensity-modulated arc therapy (IMAT) techniques in the context of the number of multi-leaf collimator (MLC) segments required to achieve plan objectives ... Full text Link to item Cite

SU-DD-A3-05: On-Board SPECT: Localization Study Using Scanner-Acquired Data

Journal Article Medical Physics · 2010 Cite

SU‐GG‐I‐140: Maximum Intensity Projection (MIP) Imaging Using Multi‐Slice Cine MRI

Conference Medical Physics · January 1, 2010 Purpose: To propose a novel method of acquiring Maximum Intensity Projection (MIP) images using multi‐slice cine MRI, termed as MRI‐MIP, and to evaluate its feasibility in quantifying motion magnitude. Materials and Methods: MRI‐MIP images are acquired usi ... Full text Cite

SU‐GG‐T‐483: Does Breath‐Hold Immobilization Affect Tumor Radioresistance in Breast?

Conference Medical Physics · January 1, 2010 Purpose: A 15–30s Breath Hold (BH) is often used in radiation therapy for breast cancer patients to minimize heart dose, however its effect on tumor oxygenation and radiosensitivity is unknown. The purpose of this study is to utilize published data on the ... Full text Cite

TU‐A‐204B‐04: A Technique to Correct Crescent Artifacts in On‐Board CBCT

Conference Medical Physics · January 1, 2010 Purpose: Large dark and bright crescents are commonly seen in cone‐beam (CB) CT images acquired onboard radiation therapy machines. The purpose of this project is to develop a technique for removing this artifact. Method and Materials: We propose that cres ... Full text Cite

TU‐C‐204B‐06: Performance Evaluation of a Dual Cone‐Beam CT (Dual CBCT) System

Conference Medical Physics · January 1, 2010 Purpose: Very little information is available for clinical CBCT imaging using a dual‐detector system. This study assesses the performance of a recently developed bench‐top dual large‐flat‐panel detectors cone beam computed tomography (CBCT) system and to c ... Full text Cite

SU‐GG‐J‐80: Characterization of Cross Scatter in Dual Source CBCT

Conference Medical Physics · January 1, 2010 Purpose: A dual‐source CBCT imaging system provides an efficient means to perform 3D and 4D imaging, but the addition of the second imaging chain produces additional scattered photons or cross scatter. The purpose of this study is to characterize cross sca ... Full text Cite

SU‐GG‐T‐136: Treatment Plans Comparison with Static‐Gantry IMRT and RapidArcTM for Head‐And‐Neck Cancers Involving Cervical Lymph Nodes

Conference Medical Physics · January 1, 2010 Purpose: To compare the dosimetric results and treatment efficiency of intensity modulated arc therapy using RapidArc™ to static‐gantry IMRT plans for conventional fractionation treatment of head‐and‐neck cancer. Materials and Methods: This study evaluated ... Full text Cite

SU‐GG‐T‐530: Comparison of Coplanar and Non‐Coplanar Intensity Modulated Arc Techniques for Treatment of Intracranial Multi‐Focal Stereotactic Radiosurgery

Conference Medical Physics · January 1, 2010 Objectives: Intensity modulated arc therapy (IMAT) can potentially be a useful technique for the treatment of multi‐focal intracranial stereotactic radiosurgery (SRS) with a single isocenter setup. This study compares the effects of coplanar and non‐coplan ... Full text Cite

SU‐GG‐J‐67: Evaluating Dynamic Magnetic Resonance Imaging Using a New Design of Phantom: Validation with Fast Megavoltage Fluoroscopic Imaging

Conference Medical Physics · January 1, 2010 Purpose: To devlope a reliable and economic phantom for motion management study and investigate its feasibility in evaluating dynamic MRI. Method and Materials: Experiments was performed using an in‐house developed phantom that consists of a platform, a lo ... Full text Cite

TU‐B‐201B‐02: Self‐Sorted Four‐Dimensional CT Using Body Volume as Respiratory Surrogate

Conference Medical Physics · January 1, 2010 Purpose: To develop a self‐sorting four‐dimensional CT (4D‐CT) technique that uses body volume as the respiratory surrogate. Method and Materials: Respiratory signals are determined by the changes in body volume at each slice location as a function of imag ... Full text Cite

SU‐GG‐I‐148: Self‐Sorted Four‐Dimensional Magnetic Resonance Imaging: A Feasibility Study

Conference Medical Physics · January 1, 2010 Purpose: Considerable imaging dose to health tissue of patient from 4D‐CT is often a concern. This study is to develop a four‐dimensional magnetic resonance imaging (4D‐MRI) technique based on retrospective sorting strategy that uses body volume as respira ... Full text Cite

SU‐GG‐I‐24: Improving IGRT Efficiency Using GPU‐Based Ultrafast Reconstruction of DTS/CBCT and DRR

Conference Medical Physics · January 1, 2010 Purpose: One challenge of on‐line image‐guided radiation therapy is requirement of immediate availability of reconstructed 3D or 4D images for evaluation. This study is to develop a highly data‐parallel version and platform of accelerating reconstruction f ... Full text Cite

SU‐GG‐J‐62: Use Winston‐Lutz Test to Check Cone Beam CT Isocenter Accuracy for Imaging Guided Intracranial Stereotactic Radiosurgery

Conference Medical Physics · January 1, 2010 Objectives: Cone beam CT (CBCT) opens the era of three dimensional (3D) imaging guided stereotactic radiosurgery (SRS). The CBCT isocenter accuracy is critical for imaging guided SRS guidance. This study analyzes the daily quality assurance (QA) results of ... Full text Cite

SU‐GG‐I‐144: Accelerating Non‐Contrast‐Enhanced MRA with Inflow Inversion Recovery by Using Skipped Phase Encoding and Edge Deghosting (SPEED)

Conference Medical Physics · January 1, 2010 Purpose: Non‐contrast‐enhanced MR angigraphy (MRA) has always been a valuable clinical tool to study vasculatural diseases. The recently arising concerns of constrast agents in contrast‐enhanced MRA encouraged more use of non‐contrast‐enhanced MRA. The aim ... Full text Cite

SU‐GG‐T‐225: Gantry‐Angle Dependence of a 2D Ion Chamber Array for IMAT QA

Conference Medical Physics · January 1, 2010 Purpose: Gantry‐angle dependence of dose measurement for intensity‐modulated arc therapy (IMAT) quality assurance (QA) using a two‐dimensional ion chamber array may be significant. A new device, the gantry angle sensor, has been provided to compensate for ... Full text Cite

SU‐GG‐T‐137: Similarities between Static and Rotational Intensity Modulated Plans

Conference Medical Physics · January 1, 2010 Purpose: To explore similarities between intensity modulated radiotherapy (IMRT) and intensity modulated arc therapy (IMAT) techniques in the context of the number of multi‐leaf collimator (MLC) segments required to achieve plan objectives, the major facto ... Full text Cite

SU‐GG‐T‐583: Dosimetric Comparison of Anisotropic Analytical and Pencil Beam Convolution Algorithms in Breast Cancer Radiation Treatment Planning

Conference Medical Physics · January 1, 2010 Purpose: The anisotropic analytical algorithm (AAA) has been shown to provide more accurate dose calculation due to 3D scatter and inhomogeneity corrections than the pencil beam convolution algorithm (PBC) for inhomogeneous anatomical regions such as lung ... Full text Cite

TH‐C‐204B‐07: Development of Image‐Guided Radiosurgery with Novalis TX for Small Animal Study

Conference Medical Physics · January 1, 2010 Purpose: Developing a protocol to accomplish small animal radiosurgery study conducted at our clinic in evaluating radiation‐induced erectile dysfunction. Method and Materials: Animals were sedated and scanned using commercial CT scanner. Scans were import ... Full text Cite

SU‐GG‐T‐362: Is Distance‐Dependent Energy Correction Needed for Dosimetric Measurements Surrounding Brachytherapy Sources?

Conference Medical Physics · January 1, 2010 Purpose: The answer depends on both the dosimeter's energy response and energy spectrum at distance (point of measurement) from the source. The latter is object of this study. Method and Materials: The spectra in water were calculated with Monte Carlo code ... Full text Cite

SU‐GG‐I‐14: A Method to Estimate Cone‐Beam CT Dose Index and Cone‐Beam Dose Length Product

Conference Medical Physics · January 1, 2010 Purpose: To characterize the cone‐beam CTDI (CBCTDI) and cone‐beam dose length product (CBDLP) by Monte Carlo (MC) technique. Method and Materials: An extended CT head phantom (60cm long) and an extended CT body phantom (90cm long) were created in our BEAM ... Full text Cite

SU‐GG‐I‐57: Dose and Image Quality Evaluation for Partial and Full‐Angle Kilovoltage Cone‐Beam CT Protocols

Conference Medical Physics · January 1, 2010 Purpose: To assess imaging dose of partial and full‐angle CBCT scan protocols, and to evaluate their image quality. Method and Materials: The CTDI of the six new CBCT protocols for Varian OBI were obtained by ion chamber (IC) measurements and Monte Carlo ( ... Full text Cite

SU‐EE‐A1‐03: Arc Modulated Radiation Therapy Based on Linear Models

Conference Medical Physics · January 1, 2010 Purpose: The challenge for implementing promising Arc Modulated Radiation Therapy (AMRT) is its effectiveness of treatment planning tools to find optimal multileaf collimator (MLC) sequence and the fluence map. This study provides a new approach to the abo ... Full text Cite

WE‐B‐BRA‐03: Adaptive Image‐Guided Radiation Therapy (AIGRT) for Hypo‐Fractionated Prostate Cancer Treatment

Conference Medical Physics · January 1, 2010 Purpose: The large fractional dose of hypo‐fractionated prostate treatment requires high accuracy of daily treatment delivery. This study analyzes the performance of an adaptive IGRT (AIGRT) technique, which combines image guidance and adaptive re‐planning ... Full text Cite

TU‐E‐BRB‐03: A Planning Quality Evaluation Tool for Adaptive IMRT Treatment Based on Machine Learning

Conference Medical Physics · January 1, 2010 Purpose: To monitor the quality of adaptive IMRT plans, especially dose sparing for the organs‐at‐risk (OARs), a plan evaluation tool is developed to predict the dose volume histogram (DVH) based on patient's anatomical information and a database of high q ... Full text Cite

SU‐GG‐J‐76: Validation of a Proposed Optimal Slow Gantry Rotation Technique for On‐Board Four‐Dimensional Imaging Using Lung Patient Data

Conference Medical Physics · January 1, 2010 Purpose: Substantial efforts have been made in recent years to develop on‐board four‐dimensional (4D) imaging techniques using gantry mounted cone‐beam imaging devices. This study validates a slow gantry rotation 4D imaging protocol using lung patient data ... Full text Cite

TH‐A‐BRA‐03: TG‐104: In‐Room kV Imaging for IGRT

Conference Medical Physics · January 1, 2010 In‐room kilovoltage (kV) x‐ray imaging refers to radiographic imaging using kV x‐ray sources in the radiation treatment room. It has been widely accepted for radiotherapy target localization and treatment intervention. Task Group 104 (TG 104) reports on th ... Full text Cite

SU‐DD‐A3‐03: How Accurately Can the Internal Target Volume (ITV) from a Free‐Breathing Cone Beam Computed Tomography (FB‐CBCT) Scan Be Used for Target Verification?

Conference Medical Physics · January 1, 2010 Purpose: An internal target volume (ITV) is often identified by acquiring a free‐breathing cone‐beam computed tomography scan (FB‐CBCT) to verify patient setup of tumors affected by respiratory motion. However, its accuracy is not well understood. The purp ... Full text Cite

Dosimetry challenges for implementing emerging technologies.

Journal Article J Phys Conf Ser · 2010 Featured Publication During the last 10 years, radiation therapy technologies have gone through major changes, mainly related introduction of sophisticated delivery and imaging techniques to improve the target localization accuracy and dose conformity. While implementation of ... Full text Link to item Cite

Radiation dose from cone beam CT in a pediatric phantom: risk estimation of cancer incidence.

Journal Article AJR Am J Roentgenol · January 2010 Featured Publication OBJECTIVE: The objective of our study was to measure absorbed doses and calculate effective dose (ED) from cone beam CT (CBCT) with metal oxide semiconductor field effect transistor (MOSFET) detectors in an anthropomorphic phantom and to estimate the risk ... Full text Link to item Cite

On-line adaptive radiation therapy: feasibility and clinical study.

Journal Article J Oncol · 2010 Featured Publication The purpose of this paper is to evaluate the feasibility and clinical dosimetric benefit of an on-line, that is, with the patient in the treatment position, Adaptive Radiation Therapy (ART) system for prostate cancer treatment based on daily cone-beam CT i ... Full text Open Access Link to item Cite

Patient specific quality assurance: Transition from IMRT to IMAT

Journal Article Journal of Physics: Conference Series · January 1, 2010 Featured Publication The purpose of this study was to test a patient-specific quality assurance (QA) protocol for intensity-modulated arc radiotherapy (IMAT), and to evaluate the use of an intensity-modulated stationary radiotherapy QA device (2D ion chamber array). Thirty-nin ... Full text Cite

ExacTrac X-ray 6 degree-of-freedom image-guidance for intracranial non-invasive stereotactic radiotherapy: comparison with kilo-voltage cone-beam CT.

Journal Article Radiother Oncol · December 2009 Featured Publication BACKGROUND AND PURPOSE: To compare the residual setup errors measured with ExacTrac X-ray 6 degree-of-freedom (6D) and cone-beam computed tomography (CBCT) for a head phantom and patients receiving intracranial non-invasive fractionated stereotactic radiot ... Full text Link to item Cite

Volumetric arc intensity-modulated therapy for spine body radiotherapy: comparison with static intensity-modulated treatment.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2009 Featured Publication PURPOSE: This clinical study evaluates the feasibility of using volumetric arc-modulated treatment (VMAT) for spine stereotactic body radiotherapy (SBRT) to achieve highly conformal dose distributions that spare adjacent organs at risk (OAR) with reduced t ... Full text Link to item Cite