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Fang-Fang Yin

Gustavo S. Montana Distinguished Professor of Radiation Oncology
Radiation Oncology
Box 3295 DUMC, Durham, NC 27710
Radiation Physics, Durham, NC 27710
Office hours call 919-6602185  

Selected Publications


Generation, validation, and benchmarking of a commercial independent Monte Carlo calculation beam model for multi-target SRS.

Journal Article Z Med Phys · September 7, 2023 BACKGROUND: Dosimetric validation of single isocenter multi-target radiosurgery plans is difficult due to conditions of electronic disequilibrium and the simultaneous irradiation of multiple off-axis lesions dispersed throughout the volume. Here we report ... Full text Link to item Cite

A neural ordinary differential equation model for visualizing deep neural network behaviors in multi-parametric MRI-based glioma segmentation.

Conference Med Phys · August 2023 PURPOSE: To develop a neural ordinary differential equation (ODE) model for visualizing deep neural network behavior during multi-parametric MRI-based glioma segmentation as a method to enhance deep learning explainability. METHODS: By hypothesizing that d ... Full text Link to item Cite

Stereotactic Radiosurgery vs Conventional Radiotherapy for Localized Vertebral Metastases of the Spine: Phase 3 Results of NRG Oncology/RTOG 0631 Randomized Clinical Trial.

Journal Article JAMA Oncol · June 1, 2023 IMPORTANCE: Spine metastasis can be treated with high-dose radiation therapy with advanced delivery technology for long-term tumor and pain control. OBJECTIVE: To assess whether patient-reported pain relief was improved with stereotactic radiosurgery (SRS) ... Full text Link to item Cite

Uncertainties in the dosimetric heterogeneity correction and its potential effect on local control in lung SBRT.

Journal Article Biomed Phys Eng Express · March 7, 2023 Objective. Dose calculation in lung stereotactic body radiation therapy (SBRT) is challenging due to the low density of the lungs and small volumes. Here we assess uncertainties associated with tissue heterogeneities using different dose calculation algori ... Full text Link to item Cite

View-sharing for 4D magnetic resonance imaging with randomized projection-encoding enables improvements of respiratory motion imaging for treatment planning in abdominothoracic radiotherapy.

Journal Article Phys Imaging Radiat Oncol · January 2023 BACKGROUND AND PURPOSE: The accuracy and precision of radiation therapy are dependent on the characterization of organ-at-risk and target motion. This work aims to demonstrate a 4D magnetic resonance imaging (MRI) method for improving spatial and temporal ... Full text Link to item Cite

Quantification of lung function on CT images based on pulmonary radiomic filtering.

Journal Article Med Phys · November 2022 PURPOSE: To develop a radiomics filtering technique for characterizing spatial-encoded regional pulmonary ventilation information on lung computed tomography (CT). METHODS: The lung volume was segmented on 46 CT images, and a 3D sliding window kernel was i ... Full text Link to item Cite

Input feature design and its impact on the performance of deep learning models for predicting fluence maps in intensity-modulated radiation therapy.

Journal Article Phys Med Biol · October 21, 2022 Objective. Deep learning (DL) models for fluence map prediction (FMP) have great potential to reduce treatment planning time in intensity-modulated radiation therapy (IMRT) by avoiding the lengthy inverse optimization process. This study aims to improve th ... Full text Link to item Cite

Fast four-dimensional cone-beam computed tomography reconstruction using deformable convolutional networks.

Journal Article Med Phys · October 2022 BACKGROUND: Although four-dimensional cone-beam computed tomography (4D-CBCT) is valuable to provide onboard image guidance for radiotherapy of moving targets, it requires a long acquisition time to achieve sufficient image quality for target localization. ... Full text Link to item Cite

Radiomics: a primer on high-throughput image phenotyping.

Journal Article Abdom Radiol (NY) · September 2022 Radiomics is a high-throughput approach to image phenotyping. It uses computer algorithms to extract and analyze a large number of quantitative features from radiological images. These radiomic features collectively describe unique patterns that can serve ... Full text Link to item Cite

Improving liver tumor image contrast and synthesizing novel tissue contrasts by adaptive multiparametric MRI fusion.

Journal Article Precis Radiat Oncol · September 2022 PURPOSE: Multiparametric MRI contains rich and complementary anatomical and functional information, which is often utilized separately. This study aims to propose an adaptive multiparametric MRI (mpMRI) fusion method and examine its capability in improving ... Full text Link to item Cite

Impact of image quality on radiomics applications.

Journal Article Phys Med Biol · July 22, 2022 Radiomics features extracted from medical images have been widely reported to be useful in the patient specific outcome modeling for variety of assessment and prediction purposes. Successful application of radiomics features as imaging biomarkers, however, ... Full text Link to item Cite

Patient-specific synthetic magnetic resonance imaging generation from cone beam computed tomography for image guidance in liver stereotactic body radiation therapy.

Journal Article Precis Radiat Oncol · June 2022 OBJECTIVE: Despite its prevalence, cone beam computed tomography (CBCT) has poor soft-tissue contrast, making it challenging to localize liver tumors. We propose a patient-specific deep learning model to generate synthetic magnetic resonance imaging (MRI) ... Full text Link to item Cite

A geometry-guided multi-beamlet deep learning technique for CT reconstruction.

Journal Article Biomed Phys Eng Express · May 13, 2022 Purpose. Previous studies have proposed deep-learning techniques to reconstruct CT images from sinograms. However, these techniques employ large fully-connected (FC) layers for projection-to-image domain transformation, producing large models requiring sub ... Full text Link to item Cite

A radiomics-boosted deep-learning model for COVID-19 and non-COVID-19 pneumonia classification using chest x-ray images.

Conference Med Phys · May 2022 PURPOSE: To develop a deep learning model design that integrates radiomics analysis for enhanced performance of COVID-19 and non-COVID-19 pneumonia detection using chest x-ray images. METHODS: As a novel radiomics approach, a 2D sliding kernel was implemen ... Full text Link to item Cite

Patient-specific deep learning model to enhance 4D-CBCT image for radiomics analysis.

Journal Article Phys Med Biol · April 1, 2022 Objective.4D-CBCT provides phase-resolved images valuable for radiomics analysis for outcome prediction throughout treatment courses. However, 4D-CBCT suffers from streak artifacts caused by under-sampling, which severely degrades the accuracy of radiomic ... Full text Link to item Cite

Enhancement of 4-D Cone-Beam Computed Tomography (4D-CBCT) Using a Dual-Encoder Convolutional Neural Network (DeCNN).

Journal Article IEEE Trans Radiat Plasma Med Sci · February 2022 4D-CBCT is a powerful tool to provide respiration-resolved images for the moving target localization. However, projections in each respiratory phase are intrinsically under-sampled under the clinical scanning time and imaging dose constraints. Images recon ... Full text Link to item Cite

The Effect of Various Dose Normalization Strategies When Implementing Linear Boltzmann Transport Equation Dose Calculation for Lung Stereotactic Body Radiation Therapy Planning.

Journal Article Pract Radiat Oncol · 2022 PURPOSE: To explore implications of various plan normalizations when implementing a linear Boltzmann transport equation solver dose calculation algorithm (LBTE) for lung stereotactic body radiation therapy (SBRT). METHODS AND MATERIALS: Eighty-seven plans ... Full text Link to item Cite

Evaluation of two automated treatment planning techniques for multiple brain metastases using a single isocenter.

Journal Article J Radiosurg SBRT · 2022 Two automated treatment planning techniques were evaluated for multiple brain metastases using a single isocenter. One technique is knowledge-based planning (KBP) using a stereotactic radiosurgery (SRS) model in Eclipse treatment planning system (TPS); and ... Link to item Cite

Post-Radiotherapy PET Image Outcome Prediction by Deep Learning Under Biological Model Guidance: A Feasibility Study of Oropharyngeal Cancer Application.

Journal Article Front Oncol · 2022 PURPOSE: To develop a method of biologically guided deep learning for post-radiation 18FDG-PET image outcome prediction based on pre-radiation images and radiotherapy dose information. METHODS: Based on the classic reaction-diffusion mechanism, a novel bio ... Full text Link to item Cite

Dosimetric variation in preoperative partial breast radiosurgery assessed by deformable image registrations.

Journal Article J Radiosurg SBRT · 2022 OBJECTIVE: To assess dosimetric variation caused by breast deformation in breast radiosurgery based on deformable image registration. METHODS: This study included 30 patients who were treated in the prone position for preoperative partial breast radiosurge ... Link to item Cite

Generation, validation, and benchmarking of a commercial independent Monte Carlo calculation beam model for multi-target SRS.

Journal Article Z Med Phys · September 7, 2023 BACKGROUND: Dosimetric validation of single isocenter multi-target radiosurgery plans is difficult due to conditions of electronic disequilibrium and the simultaneous irradiation of multiple off-axis lesions dispersed throughout the volume. Here we report ... Full text Link to item Cite

A neural ordinary differential equation model for visualizing deep neural network behaviors in multi-parametric MRI-based glioma segmentation.

Conference Med Phys · August 2023 PURPOSE: To develop a neural ordinary differential equation (ODE) model for visualizing deep neural network behavior during multi-parametric MRI-based glioma segmentation as a method to enhance deep learning explainability. METHODS: By hypothesizing that d ... Full text Link to item Cite

Stereotactic Radiosurgery vs Conventional Radiotherapy for Localized Vertebral Metastases of the Spine: Phase 3 Results of NRG Oncology/RTOG 0631 Randomized Clinical Trial.

Journal Article JAMA Oncol · June 1, 2023 IMPORTANCE: Spine metastasis can be treated with high-dose radiation therapy with advanced delivery technology for long-term tumor and pain control. OBJECTIVE: To assess whether patient-reported pain relief was improved with stereotactic radiosurgery (SRS) ... Full text Link to item Cite

Uncertainties in the dosimetric heterogeneity correction and its potential effect on local control in lung SBRT.

Journal Article Biomed Phys Eng Express · March 7, 2023 Objective. Dose calculation in lung stereotactic body radiation therapy (SBRT) is challenging due to the low density of the lungs and small volumes. Here we assess uncertainties associated with tissue heterogeneities using different dose calculation algori ... Full text Link to item Cite

View-sharing for 4D magnetic resonance imaging with randomized projection-encoding enables improvements of respiratory motion imaging for treatment planning in abdominothoracic radiotherapy.

Journal Article Phys Imaging Radiat Oncol · January 2023 BACKGROUND AND PURPOSE: The accuracy and precision of radiation therapy are dependent on the characterization of organ-at-risk and target motion. This work aims to demonstrate a 4D magnetic resonance imaging (MRI) method for improving spatial and temporal ... Full text Link to item Cite

Quantification of lung function on CT images based on pulmonary radiomic filtering.

Journal Article Med Phys · November 2022 PURPOSE: To develop a radiomics filtering technique for characterizing spatial-encoded regional pulmonary ventilation information on lung computed tomography (CT). METHODS: The lung volume was segmented on 46 CT images, and a 3D sliding window kernel was i ... Full text Link to item Cite

Input feature design and its impact on the performance of deep learning models for predicting fluence maps in intensity-modulated radiation therapy.

Journal Article Phys Med Biol · October 21, 2022 Objective. Deep learning (DL) models for fluence map prediction (FMP) have great potential to reduce treatment planning time in intensity-modulated radiation therapy (IMRT) by avoiding the lengthy inverse optimization process. This study aims to improve th ... Full text Link to item Cite

Fast four-dimensional cone-beam computed tomography reconstruction using deformable convolutional networks.

Journal Article Med Phys · October 2022 BACKGROUND: Although four-dimensional cone-beam computed tomography (4D-CBCT) is valuable to provide onboard image guidance for radiotherapy of moving targets, it requires a long acquisition time to achieve sufficient image quality for target localization. ... Full text Link to item Cite

Radiomics: a primer on high-throughput image phenotyping.

Journal Article Abdom Radiol (NY) · September 2022 Radiomics is a high-throughput approach to image phenotyping. It uses computer algorithms to extract and analyze a large number of quantitative features from radiological images. These radiomic features collectively describe unique patterns that can serve ... Full text Link to item Cite

Improving liver tumor image contrast and synthesizing novel tissue contrasts by adaptive multiparametric MRI fusion.

Journal Article Precis Radiat Oncol · September 2022 PURPOSE: Multiparametric MRI contains rich and complementary anatomical and functional information, which is often utilized separately. This study aims to propose an adaptive multiparametric MRI (mpMRI) fusion method and examine its capability in improving ... Full text Link to item Cite

Impact of image quality on radiomics applications.

Journal Article Phys Med Biol · July 22, 2022 Radiomics features extracted from medical images have been widely reported to be useful in the patient specific outcome modeling for variety of assessment and prediction purposes. Successful application of radiomics features as imaging biomarkers, however, ... Full text Link to item Cite

Patient-specific synthetic magnetic resonance imaging generation from cone beam computed tomography for image guidance in liver stereotactic body radiation therapy.

Journal Article Precis Radiat Oncol · June 2022 OBJECTIVE: Despite its prevalence, cone beam computed tomography (CBCT) has poor soft-tissue contrast, making it challenging to localize liver tumors. We propose a patient-specific deep learning model to generate synthetic magnetic resonance imaging (MRI) ... Full text Link to item Cite

A geometry-guided multi-beamlet deep learning technique for CT reconstruction.

Journal Article Biomed Phys Eng Express · May 13, 2022 Purpose. Previous studies have proposed deep-learning techniques to reconstruct CT images from sinograms. However, these techniques employ large fully-connected (FC) layers for projection-to-image domain transformation, producing large models requiring sub ... Full text Link to item Cite

A radiomics-boosted deep-learning model for COVID-19 and non-COVID-19 pneumonia classification using chest x-ray images.

Conference Med Phys · May 2022 PURPOSE: To develop a deep learning model design that integrates radiomics analysis for enhanced performance of COVID-19 and non-COVID-19 pneumonia detection using chest x-ray images. METHODS: As a novel radiomics approach, a 2D sliding kernel was implemen ... Full text Link to item Cite

Patient-specific deep learning model to enhance 4D-CBCT image for radiomics analysis.

Journal Article Phys Med Biol · April 1, 2022 Objective.4D-CBCT provides phase-resolved images valuable for radiomics analysis for outcome prediction throughout treatment courses. However, 4D-CBCT suffers from streak artifacts caused by under-sampling, which severely degrades the accuracy of radiomic ... Full text Link to item Cite

Enhancement of 4-D Cone-Beam Computed Tomography (4D-CBCT) Using a Dual-Encoder Convolutional Neural Network (DeCNN).

Journal Article IEEE Trans Radiat Plasma Med Sci · February 2022 4D-CBCT is a powerful tool to provide respiration-resolved images for the moving target localization. However, projections in each respiratory phase are intrinsically under-sampled under the clinical scanning time and imaging dose constraints. Images recon ... Full text Link to item Cite

The Effect of Various Dose Normalization Strategies When Implementing Linear Boltzmann Transport Equation Dose Calculation for Lung Stereotactic Body Radiation Therapy Planning.

Journal Article Pract Radiat Oncol · 2022 PURPOSE: To explore implications of various plan normalizations when implementing a linear Boltzmann transport equation solver dose calculation algorithm (LBTE) for lung stereotactic body radiation therapy (SBRT). METHODS AND MATERIALS: Eighty-seven plans ... Full text Link to item Cite

Evaluation of two automated treatment planning techniques for multiple brain metastases using a single isocenter.

Journal Article J Radiosurg SBRT · 2022 Two automated treatment planning techniques were evaluated for multiple brain metastases using a single isocenter. One technique is knowledge-based planning (KBP) using a stereotactic radiosurgery (SRS) model in Eclipse treatment planning system (TPS); and ... Link to item Cite

Post-Radiotherapy PET Image Outcome Prediction by Deep Learning Under Biological Model Guidance: A Feasibility Study of Oropharyngeal Cancer Application.

Journal Article Front Oncol · 2022 PURPOSE: To develop a method of biologically guided deep learning for post-radiation 18FDG-PET image outcome prediction based on pre-radiation images and radiotherapy dose information. METHODS: Based on the classic reaction-diffusion mechanism, a novel bio ... Full text Link to item Cite

Dosimetric variation in preoperative partial breast radiosurgery assessed by deformable image registrations.

Journal Article J Radiosurg SBRT · 2022 OBJECTIVE: To assess dosimetric variation caused by breast deformation in breast radiosurgery based on deformable image registration. METHODS: This study included 30 patients who were treated in the prone position for preoperative partial breast radiosurge ... Link to item Cite

Transfer learning for fluence map prediction in adrenal stereotactic body radiation therapy.

Conference Phys Med Biol · December 6, 2021 Objective:To design a deep transfer learning framework for modeling fluence map predictions for stereotactic body radiation therapy (SBRT) of adrenal cancer and similar sites that usually have a small number of cases.Approach:We developed a transfer learni ... Full text Link to item Cite

Prior image-guided cone-beam computed tomography augmentation from under-sampled projections using a convolutional neural network.

Journal Article Quant Imaging Med Surg · December 2021 BACKGROUND: Acquiring sparse-view cone-beam computed tomography (CBCT) is an effective way to reduce the imaging dose. However, images reconstructed by the conventional filtered back-projection method suffer from severe streak artifacts due to the projecti ... Full text Link to item Cite

Artificial intelligence applications in intensity modulated radiation treatment planning: an overview.

Journal Article Quant Imaging Med Surg · December 2021 Artificial intelligence (AI) refers to methods that improve and automate challenging human tasks by systematically capturing and applying relevant knowledge in these tasks. Over the past decades, a number of approaches have been developed to address differ ... Full text Link to item Cite

Multi-contrast four-dimensional magnetic resonance imaging (MC-4D-MRI): Development and initial evaluation in liver tumor patients.

Journal Article Med Phys · December 2021 PURPOSE: To develop a novel multi-contrast four-dimensional magnetic resonance imaging (MC-4D-MRI) technique that expands single image contrast 4D-MRI to a spectrum of native and synthetic image contrasts and to evaluate its feasibility in liver tumor pati ... Full text Link to item Cite

Assessing the robustness of artificial intelligence powered planning tools in radiotherapy clinical settings-a phantom simulation approach.

Journal Article Quant Imaging Med Surg · December 2021 BACKGROUND: Artificial intelligence (AI) based radiotherapy treatment planning tools have gained interest in automating the treatment planning process. It is essential to understand their overall robustness in various clinical scenarios. This is an existin ... Full text Link to item Cite

Insights of an AI agent via analysis of prediction errors: a case study of fluence map prediction for radiation therapy planning.

Journal Article Phys Med Biol · November 26, 2021 Purpose.We have previously reported an artificial intelligence (AI) agent that automatically generates intensity-modulated radiation therapy (IMRT) plans via fluence map prediction, by-passing inverse planning. This AI agent achieved clinically comparable ... Full text Link to item Cite

A Dosimetric Study Comparing Two Beam Arrangement Strategies in Fractionated Thoracic Spine Stereotactic Body Radiotherapy (SBRT) Planning.

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)To compare dosimetric results of two beam arrangement strategies and their robustness to setup uncertainties in fractionated thoracic spine Stereotactic Body Radiotherapy (SBRT) MATERIALS/METHODS: Fifteen patients who received ... Full text Cite

AAPM Task Group 198 Report: An implementation guide for TG 142 quality assurance of medical accelerators.

Journal Article Med Phys · October 2021 The charges on this task group (TG) were as follows: (a) provide specific procedural guidelines for performing the tests recommended in TG 142; (b) provide estimate of the range of time, appropriate personnel, and qualifications necessary to complete the t ... Full text Link to item Cite

A comparison of two methodologies for radiotherapy treatment plan optimization and QA for clinical trials.

Journal Article J Appl Clin Med Phys · October 2021 BACKGROUND AND PURPOSE: The efficacy of clinical trials and the outcome of patient treatment are dependent on the quality assurance (QA) of radiation therapy (RT) plans. There are two widely utilized approaches that include plan optimization guidance creat ... Full text Link to item Cite

A geometry-guided deep learning technique for CBCT reconstruction.

Journal Article Phys Med Biol · July 30, 2021 Purpose.Although deep learning (DL) technique has been successfully used for computed tomography (CT) reconstruction, its implementation on cone-beam CT (CBCT) reconstruction is extremely challenging due to memory limitations. In this study, a novel DL tec ... Full text Link to item Cite

Intrinsic radiomic expression patterns after 20 Gy demonstrate early metabolic response of oropharyngeal cancers.

Journal Article Medical physics · July 2021 PurposeThis study investigated the prognostic potential of intra-treatment PET radiomics data in patients undergoing definitive (chemo) radiation therapy for oropharyngeal cancer (OPC) on a prospective clinical trial. We hypothesized that the radi ... Full text Cite

An artificial intelligence-driven agent for real-time head-and-neck IMRT plan generation using conditional generative adversarial network (cGAN).

Journal Article Med Phys · June 2021 PURPOSE: To develop an artificial intelligence (AI) agent for fully automated rapid head-and-neck intensity-modulated radiation therapy (IMRT) plan generation without time-consuming dose-volume-based inverse planning. METHODS: This AI agent was trained via ... Full text Link to item Cite

A generative adversarial network (GAN)-based technique for synthesizing realistic respiratory motion in the extended cardiac-torso (XCAT) phantoms.

Journal Article Phys Med Biol · May 31, 2021 Objective. Synthesize realistic and controllable respiratory motions in the extended cardiac-torso (XCAT) phantoms by developing a generative adversarial network (GAN)-based deep learning technique.Methods. A motion generation model was developed using bic ... Full text Link to item Cite

Radiogenomic Analysis of Locally Advanced Lung Cancer Based on CT Imaging and Intratreatment Changes in Cell-Free DNA.

Journal Article Radiol Imaging Cancer · April 2021 The radiologic appearance of locally advanced lung cancer may be linked to molecular changes of the disease during treatment, but characteristics of this phenomenon are poorly understood. Radiomics, liquid biopsy of cell-free DNA (cfDNA), and next-generati ... Full text Link to item Cite

An Interpretable Planning Bot for Pancreas Stereotactic Body Radiation Therapy.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2021 PURPOSE: Pancreas stereotactic body radiation therapy (SBRT) treatment planning requires planners to make sequential, time-consuming interactions with the treatment planning system to reach the optimal dose distribution. We sought to develop a reinforcemen ... Full text Link to item Cite

4D radiomics: impact of 4D-CBCT image quality on radiomic analysis.

Journal Article Phys Med Biol · February 11, 2021 PURPOSE: To investigate the impact of 4D-CBCT image quality on radiomic analysis and the efficacy of using deep learning based image enhancement to improve the accuracy of radiomic features of 4D-CBCT. MATERIAL AND METHODS: In this study, 4D-CT data from 1 ... Full text Link to item Cite

Evaluation of eddy current distortion and field inhomogeneity distortion corrections in MR diffusion imaging using log-demons DIR method.

Journal Article Phys Med Biol · January 29, 2021 To investigate the feasibility of the log-demons deformable image registration (DIR) method to correct eddy current and field inhomogeneity distortions while preserving diffusion tensor information. Diffusion-weighted images (DWIs) are susceptible to disto ... Full text Link to item Cite

Enhancing digital tomosynthesis (DTS) for lung radiotherapy guidance using patient-specific deep learning model.

Journal Article Phys Med Biol · January 26, 2021 Digital tomosynthesis (DTS) has been proposed as a fast low-dose imaging technique for image-guided radiation therapy (IGRT). However, due to the limited scanning angle, DTS reconstructed by the conventional FDK method suffers from significant distortions ... Full text Link to item Cite

Slice-stacking T2-weighted MRI for fast determination of internal target volume for liver tumor.

Journal Article Quant Imaging Med Surg · January 2021 BACKGROUND: To investigate the feasibility of generating maximum intensity projection (MIP) images to determine internal target volume (ITV) using slice-stacking MRI (SS-MRI) technique. METHODS: Slice-stacking is a technique which applies a multi-slice MRI ... Full text Link to item Cite

Clinical Experience With Machine Learning-Based Automated Treatment Planning for Whole Breast Radiation Therapy.

Journal Article Adv Radiat Oncol · 2021 PURPOSE: The machine learning-based automated treatment planning (MLAP) tool has been developed and evaluated for breast radiation therapy planning at our institution. We implemented MLAP for patient treatment and assessed our clinical experience for its p ... Full text Open Access Link to item Cite

Deep Learning-Based Fluence Map Prediction for Pancreas Stereotactic Body Radiation Therapy With Simultaneous Integrated Boost.

Journal Article Adv Radiat Oncol · 2021 PURPOSE: Treatment planning for pancreas stereotactic body radiation therapy (SBRT) is a challenging task, especially with simultaneous integrated boost treatment approaches. We propose a deep learning (DL) framework to accurately predict fluence maps from ... Full text Link to item Cite

Radiomics and Outcome Prediction

Conference MEDICAL PHYSICS · 2021 Cite

Outcomes in Patients With 4 to 10 Brain Metastases Treated With Dose-Adapted Single-Isocenter Multitarget Stereotactic Radiosurgery: A Prospective Study.

Journal Article Adv Radiat Oncol · 2021 PURPOSE: To examine the effectiveness and safety of single-isocenter multitarget stereotactic radiosurgery using a volume-adapted dosing strategy in patients with 4 to 10 brain metastases. METHODS AND MATERIALS: Adult patients with 4 to 10 brain metastases ... Full text Link to item Cite

RETRACTED: An Encoder-Decoder Based Deep Learning AI agent for Spatial Dose Distribution Prediction: A Study of Complex Head-and-Neck IMRT Application

Conference International journal of radiation oncology, biology, physics · November 1, 2020 This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This abstract has been retracted at the request of the authors. After submitting this abstract the authors realized that th ... Full text Cite

RETRACTED: An Encoder-Decoder Based Deep Learning AI agent for Spatial Dose Distribution Prediction: A Study of Complex Head-and-Neck IMRT Application.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2020 This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This abstract has been retracted at the request of the authors. After submitting this abstract the authors realized that th ... Full text Link to item Cite

Automatic detection of pulmonary nodules on CT images with YOLOv3: development and evaluation using simulated and patient data.

Journal Article Quant Imaging Med Surg · October 2020 BACKGROUND: To develop a high-efficiency pulmonary nodule computer-aided detection (CAD) method for localization and diameter estimation. METHODS: The developed CAD method centralizes a novel convolutional neural network (CNN) algorithm, You Only Look Once ... Full text Link to item Cite

Automatic detection of pulmonary nodules on CT images with YOLOv3: development and evaluation using simulated and patient data

Journal Article Quantitative imaging in medicine and surgery · October 2020 Background To develop a high-efficiency pulmonary nodule computer-aided detection (CAD) method for localization and diameter estimation. Methods The developed CAD method centralizes a novel convolutional neural network (CNN) algorithm, You Only Look Once ( ... Cite

Adaptive respiratory signal prediction using dual multi-layer perceptron neural networks.

Journal Article Phys Med Biol · September 14, 2020 To improve the prediction accuracy of respiratory signals by adapting the multi-layer perceptron neural network (MLP-NN) model to changing respiratory signals. We have previously developed an MLP-NN to predict respiratory signals obtained from a real-time ... Full text Link to item Cite

Automatic IMRT planning via static field fluence prediction (AIP-SFFP): a deep learning algorithm for real-time prostate treatment planning.

Journal Article Phys Med Biol · September 8, 2020 The purpose of this work was to develop a deep learning (DL) based algorithm, Automatic intensity-modulated radiotherapy (IMRT) Planning via Static Field Fluence Prediction (AIP-SFFP), for automated prostate IMRT planning with real-time planning efficiency ... Full text Link to item Cite

Retrospective quality metrics review of stereotactic radiosurgery plans treating multiple targets using single-isocenter volumetric modulated arc therapy.

Journal Article J Appl Clin Med Phys · June 2020 PURPOSE: To characterize key plan quality metrics in multi-target stereotactic radiosurgery (SRS) plans treated using single-isocenter volumetric modulated arc therapy (VMAT) in comparison to dynamic conformal arc (DCA) plans treating single target. To inv ... Full text Link to item Cite

Knowledge-Based Tradeoff Hyperplanes for Head and Neck Treatment Planning.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2020 PURPOSE: To develop a tradeoff hyperplane model to facilitate tradeoff decision-making before inverse planning. METHODS AND MATERIALS: We propose a model-based approach to determine the tradeoff hyperplanes that allow physicians to navigate the clinically ... Full text Link to item Cite

Development of realistic multi-contrast textured XCAT (MT-XCAT) phantoms using a dual-discriminator conditional-generative adversarial network (D-CGAN).

Journal Article Phys Med Biol · March 19, 2020 Develop a machine learning-based method to generate multi-contrast anatomical textures in the 4D extended cardiac-torso (XCAT) phantom for more realistic imaging simulations. As a pilot study, we synthesize CT and CBCT textures in the chest region. For tra ... Full text Link to item Cite

Digital phantoms for characterizing inconsistencies among radiomics extraction toolboxes.

Journal Article Biomed Phys Eng Express · March 2, 2020 PURPOSE: to develop digital phantoms for characterizing inconsistencies among radiomics extraction methods based on three radiomics toolboxes: CERR (Computational Environment for Radiological Research), IBEX (imaging biomarker explorer), and an in-house ra ... Full text Link to item Cite

Motion robust 4D-MRI sorting based on anatomic feature matching: A digital phantom simulation study.

Journal Article Radiat Med Prot · March 2020 PURPOSE: Motion artifacts induced by breathing variations are common in 4D-MRI images. This study aims to reduce the motion artifacts by developing a novel, robust 4D-MRI sorting method based on anatomic feature matching and applicable in both cine and seq ... Full text Link to item Cite

Volumetric cine magnetic resonance imaging (VC-MRI) using motion modeling, free-form deformation and multi-slice undersampled 2D cine MRI reconstructed with spatio-temporal low-rank decomposition.

Journal Article Quant Imaging Med Surg · February 2020 BACKGROUND: The purpose of this study is to improve on-board volumetric cine magnetic resonance imaging (VC-MRI) using multi-slice undersampled cine images reconstructed using spatio-temporal k-space data, patient prior 4D-MRI, motion modeling (MM) and fre ... Full text Link to item Cite

A multi-scale framework with unsupervised joint training of convolutional neural networks for pulmonary deformable image registration.

Journal Article Phys Med Biol · January 13, 2020 To achieve accurate and fast deformable image registration (DIR) for pulmonary CT, we proposed a Multi-scale DIR framework with unsupervised Joint training of Convolutional Neural Network (MJ-CNN). MJ-CNN contains three models at multi-scale levels for a c ... Full text Link to item Cite

Dose-Distribution-Driven PET Image-Based Outcome Prediction (DDD-PIOP): A Deep Learning Study for Oropharyngeal Cancer IMRT Application

Conference Frontiers in oncology · January 2020 Purpose To develop a deep learning-based AI agent, DDD-PIOP (Dose-Distribution-Driven PET Image Outcome Prediction), for predicting 18FDG-PET image outcomes of oropharyngeal cancer (OPC) in response to intensity-modulated radiation therapy (IMRT). Methods ... Cite

Technical Note: Investigation of the dosimetric impact of stray radiation on the Common Control Unit of the IBA Blue Phantom2.

Journal Article J Appl Clin Med Phys · January 2020 PURPOSE: This technical note aims to investigate the dosimetric impact of stray radiation on the Common Control Unit (CCU) of the IBA Blue Phantom2 and the measured beam data. METHODS: Three CCUs of the same model were used for the study. The primary test ... Full text Link to item Cite

Accuracy and efficiency of image-guided radiation therapy (IGRT) for preoperative partial breast radiosurgery.

Journal Article J Radiosurg SBRT · 2020 OBJECTIVE: To analyze and evaluate accuracy and efficiency of IGRT process for preoperative partial breast radiosurgery. METHODS: Patients were initially setup with skin marks and 5 steps were performed: (1) Initial orthogonal 2D kV images, (2) pre-treatme ... Open Access Link to item Cite

Dose-Distribution-Driven PET Image-Based Outcome Prediction (DDD-PIOP): A Deep Learning Study for Oropharyngeal Cancer IMRT Application.

Journal Article Frontiers in oncology · January 2020 PurposeTo develop a deep learning-based AI agent, DDD-PIOP (Dose-Distribution-Driven PET Image Outcome Prediction), for predicting 18FDG-PET image outcomes of oropharyngeal cancer (OPC) in response to intensity-modulated radiation thera ... Full text Open Access Cite

NRG Oncology Survey on Practice and Technology Use in SRT and SBRT Delivery.

Journal Article Front Oncol · 2020 PURPOSE: To assess stereotactic radiotherapy (SRT)/stereotactic body radiotherapy (SBRT) practices by polling clinics participating in multi-institutional clinical trials. METHODS: The NRG Oncology Medical Physics Subcommittee distributed a survey consisti ... Full text Open Access Link to item Cite

Knowledge Models as Teaching Aid for Training Intensity Modulated Radiation Therapy Planning: A Lung Cancer Case Study.

Journal Article Front Artif Intell · 2020 Purpose: Artificial intelligence (AI) employs knowledge models that often behave as a black-box to the majority of users and are not designed to improve the skill level of users. In this study, we aim to demonstrate the feasibility that AI can serve as an ... Full text Link to item Cite

Fluence Map Prediction Using Deep Learning Models - Direct Plan Generation for Pancreas Stereotactic Body Radiation Therapy.

Journal Article Front Artif Intell · 2020 Purpose: Treatment planning for pancreas stereotactic body radiation therapy (SBRT) is a difficult and time-consuming task. In this study, we aim to develop a novel deep learning framework to generate clinical-quality plans by direct prediction of fluence ... Full text Open Access Link to item Cite

Augmentation of CBCT Reconstructed From Under-Sampled Projections Using Deep Learning.

Journal Article IEEE Trans Med Imaging · November 2019 Edges tend to be over-smoothed in total variation (TV) regularized under-sampled images. In this paper, symmetric residual convolutional neural network (SR-CNN), a deep learning based model, was proposed to enhance the sharpness of edges and detailed anato ... Full text Link to item Cite

Liver 4D-MRI: An Image Mutual Information based Retrospective Self-sorting Method

Conference 2019 International Conference on Medical Imaging Physics and Engineering, ICMIPE 2019 · November 1, 2019 Four-dimensional MRI (4D-MRI) is an emerging technique for soft-tissue motion management in radiotherapy treatment planning. The purpose of this study was to develop a novel image mutual information (MI) based retrospective 4DMRI sorting method that is ful ... Full text Cite

Task Group 174 Report: Utilization of [18 F]Fluorodeoxyglucose Positron Emission Tomography ([18 F]FDG-PET) in Radiation Therapy.

Journal Article Med Phys · October 2019 The use of positron emission tomography (PET) in radiation therapy (RT) is rapidly increasing in the areas of staging, segmentation, treatment planning, and response assessment. The most common radiotracer is 18 F-fluorodeoxyglucose ([18 F]FDG), a glucose ... Full text Open Access Link to item Cite

Daily edge deformation prediction using an unsupervised convolutional neural network model for low dose prior contour based total variation CBCT reconstruction (PCTV-CNN).

Journal Article Biomed Phys Eng Express · October 2019 PURPOSE: Previously we developed a PCTV method to enhance the edge sharpness for low-dose CBCT reconstruction. However, the iterative deformable registration method used for deforming edges from planning-CT to on-board CBCT is time-consuming and user-depen ... Full text Link to item Cite

Modeling of multiple planning target volumes for head and neck treatments in knowledge-based treatment planning.

Journal Article Med Phys · September 2019 PURPOSE: The purpose of this study is to develop an accurate and reliable dose volume histogram (DVH) prediction method for external beam radiation therapy plans with multiple planning target volumes (PTVs). MATERIALS AND METHODS: We present a novel DVH pr ... Full text Link to item Cite

LINAC based stereotactic radiosurgery for multiple brain metastases: guidance for clinical implementation.

Journal Article Acta Oncol · September 2019 Introduction: Stereotactic radiosurgery (SRS) is a promising treatment option for patients with multiple brain metastases (BM). Recent technical advances have made LINAC based SRS a patient friendly technique, allowing for accurate patient positioning and ... Full text Link to item Cite

Feasibility of radiosurgery dosimetry using NIPAM 3D dosimeters and x-ray CT

Conference Journal of Physics: Conference Series · August 29, 2019 We investigated the feasibility of using N-isopropylacrylamide (NIPAM) dosimeters with x-ray CT to verify radiosurgery dose. Dosimeters were prepared at one facility and shipped to a second facility for irradiation. A simulation CT was acquired and plans p ... Full text Cite

Predicting real-time 3D deformation field maps (DFM) based on volumetric cine MRI (VC-MRI) and artificial neural networks for on-board 4D target tracking: a feasibility study.

Journal Article Phys Med Biol · August 21, 2019 To predict real-time 3D deformation field maps (DFMs) using Volumetric Cine MRI (VC-MRI) and adaptive boosting and multi-layer perceptron neural network (ADMLP-NN) for 4D target tracking. One phase of a prior 4D-MRI is set as the prior phase, MRIprior. Pri ... Full text Link to item Cite

An Exploratory Radiomics Approach to Quantifying Pulmonary Function in CT Images.

Journal Article Sci Rep · August 8, 2019 Contemporary medical imaging is becoming increasingly more quantitative. The emerging field of radiomics is a leading example. By translating unstructured data (i.e., images) into structured data (i.e., imaging features), radiomics can potentially characte ... Full text Open Access Link to item Cite

Low dose cone-beam computed tomography reconstruction via hybrid prior contour based total variation regularization (hybrid-PCTV).

Journal Article Quant Imaging Med Surg · July 2019 BACKGROUND: Previously, we developed a prior contour based total variation (PCTV) method to use edge information derived from prior images for edge enhancement in low-dose cone-beam computed tomography (CBCT) reconstruction. However, the accuracy of edge e ... Full text Link to item Cite

A robust deformable image registration enhancement method based on radial basis function.

Journal Article Quant Imaging Med Surg · July 2019 BACKGROUND: To develop and evaluate a robust deformable image registration (DIR) enhancement method based on radial basis function (RBF) expansion. METHODS: To improve DIR accuracy using sparsely available measured displacements, it is crucial to estimate ... Full text Open Access Link to item Cite

Probability-based 3D k-space sorting for motion robust 4D-MRI.

Journal Article Quant Imaging Med Surg · July 2019 BACKGROUND: Current 4D-MRI techniques are prone to breathing-variation-induced motion artifacts. This study developed a novel method for motion-robust multi-cycle 4D-MRI using probability-based multi-cycle sorting to overcome this deficiency. METHODS: The ... Full text Link to item Cite

A hybrid proton and hyperpolarized gas tagging MRI technique for lung respiratory motion imaging: a feasibility study.

Journal Article Phys Med Biol · May 16, 2019 The aim of this work was to develop a novel hybrid 3D hyperpolarized (HP) gas tagging MRI (t-MRI) technique and to evaluate it for lung respiratory motion measurement with comparison to deformable image registrations (DIR) methods. Three healthy subjects u ... Full text Link to item Cite

First clinical retrospective investigation of limited projection CBCT for lung tumor localization in patients receiving SBRT treatment.

Journal Article Phys Med Biol · May 8, 2019 To clinically investigate the limited-projection CBCT (LP-CBCT) technology for daily positioning of patients receiving breath-hold lung SBRT radiation treatment and to investigate the feasibility of reconstructing fast 4D-CBCT from 1 min 3D-CBCT scan. Elev ... Full text Link to item Cite

Genetic Single Neuron Anatomy Reveals Fine Granularity of Cortical Axo-Axonic Cells.

Journal Article Cell Rep · March 12, 2019 Parsing diverse nerve cells into biological types is necessary for understanding neural circuit organization. Morphology is an intuitive criterion for neuronal classification and a proxy of connectivity, but morphological diversity and variability often pr ... Full text Link to item Cite

A Spatiotemporal-Constrained Sorting Method for Motion-Robust 4D-MRI: A Feasibility Study.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2019 PURPOSE: To develop a spatiotemporal-constrained sorting technique for motion-robust 4 dimensional-magnetic resonance imaging. METHODS AND MATERIALS: This sorting method implemented 2 new approaches for 4-dimensional imaging: (1) an optimized sparse k-spac ... Full text Link to item Cite

Evaluation of dosimetric uncertainty caused by MR geometric distortion in MRI-based liver SBRT treatment planning.

Journal Article J Appl Clin Med Phys · February 2019 PURPOSE: MRI-based treatment planning is a promising technique for liver stereotactic-body radiation therapy (SBRT) treatment planning to improve target volume delineation and reduce radiation dose to normal tissues. MR geometric distortion, however, is a ... Full text Open Access Link to item Cite

Association of pre-treatment radiomic features with lung cancer recurrence following stereotactic body radiation therapy.

Journal Article Phys Med Biol · January 8, 2019 The purpose of this work was to investigate the potential relationship between radiomic features extracted from pre-treatment x-ray CT images and clinical outcomes following stereotactic body radiation therapy (SBRT) for non-small-cell lung cancer (NSCLC). ... Full text Open Access Link to item Cite

Incorporating Case-Based Reasoning for Radiation Therapy Knowledge Modeling: A Pelvic Case Study

Conference Technology in Cancer Research and Treatment · January 1, 2019 Knowledge models in radiotherapy capture the relation between patient anatomy and dosimetry to provide treatment planning guidance. When treatment schemes evolve, existing models struggle to predict accurately. We propose a case-based reasoning framework d ... Full text Cite

The effect of setup uncertainty on optimal dosimetric margin in LINAC-based stereotactic radiosurgery with dynamic conformal arc technique.

Journal Article J Radiosurg SBRT · 2019 PURPOSE: To estimate the combined effect of setup uncertainty on optimal dosimetric margin by analyzing the dose distribution and biological effect in LINAC-based stereotactic radiosurgery (SRS) with dynamic conformal arc (DCA) technique. METHODS: SRS trea ... Link to item Cite

Impact of Esophageal Motion on Dosimetry and Toxicity With Thoracic Radiation Therapy.

Journal Article Technol Cancer Res Treat · 2019 PURPOSE: To investigate the impact of intra- and inter-fractional esophageal motion on dosimetry and observed toxicity in a phase I dose escalation study of accelerated radiotherapy with concurrent chemotherapy for locally advanced lung cancer. METHODS AND ... Full text Open Access Link to item Cite

Data clustering based on Langevin annealing with a self-consistent potential

Journal Article Quarterly of Applied Mathematics · January 1, 2019 This paper introduces a novel data clustering algorithm based on Langevin dynamics, where the associated potential is constructed directly from the data. To introduce a self-consistent potential, we adopt the potential model from the established Quantum Cl ... Full text Open Access Cite

Knowledge-Based Statistical Inference Method for Plan Quality Quantification.

Journal Article Technol Cancer Res Treat · January 1, 2019 AIM: The aim of the study is to develop a geometrically adaptive and statistically robust plan quality inference method. METHODS AND MATERIALS: We propose a knowledge-based plan quality inference method that references to similar plans in the historical da ... Full text Open Access Link to item Cite

Goal-Driven Beam Setting Optimization for Whole-Breast Radiation Therapy.

Journal Article Technol Cancer Res Treat · January 1, 2019 PURPOSE: To develop an automated optimization program to generate optimal beam settings for whole-breast radiation therapy driven by clinically oriented goals. MATERIALS AND METHODS: Forty patients were retrospectively included in this study. Each patient' ... Full text Open Access Link to item Cite

Investigation of calibration-based projection domain dual energy decomposition CBCT technique for brain radiotherapy applications

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2019 The purpose of the present study was to develop and evaluate a practical dual-energy imaging approach for enhancing on-board cone-beam CT (CBCT) image quality for brain radiotherapy applications. The proposed primary technique involves a projection domain ... Full text Cite

Automatic Planning of Whole Breast Radiation Therapy Using Machine Learning Models.

Journal Article Front Oncol · 2019 Purpose: To develop an automatic treatment planning system for whole breast radiation therapy (WBRT) based on two intensity-modulated tangential fields, enabling near-real-time planning. Methods and Materials: A total of 40 WBRT plans from a single institu ... Full text Open Access Link to item Cite

Incorporating Case-Based Reasoning for Radiation Therapy Knowledge Modeling: A Pelvic Case Study.

Journal Article Technol Cancer Res Treat · January 1, 2019 Knowledge models in radiotherapy capture the relation between patient anatomy and dosimetry to provide treatment planning guidance. When treatment schemes evolve, existing models struggle to predict accurately. We propose a case-based reasoning framework d ... Full text Open Access Link to item Cite

The effect of MLC leaf width in single-isocenter multi-target radiosurgery with volumetric modulated arc therapy.

Journal Article J Radiosurg SBRT · 2019 PURPOSE: Single-isocenter multi-target (SIMT) volumetric modulated arc therapy (VMAT) is primarily limited to linear accelerators utilizing 2.5 mm leaf width MLCs. We explore feasibility of applying this technique to linear accelerators utilizing MLCs with ... Open Access Link to item Cite

An investigation of machine learning methods in delta-radiomics feature analysis.

Journal Article PLoS One · 2019 PURPOSE: This study aimed to investigate the effectiveness of using delta-radiomics to predict overall survival (OS) for patients with recurrent malignant gliomas treated by concurrent stereotactic radiosurgery and bevacizumab, and to investigate the effec ... Full text Open Access Link to item Cite

An initial investigation of hyperpolarized gas tagging magnetic resonance imaging in evaluating deformable image registration-based lung ventilation.

Journal Article Med Phys · December 2018 BACKGROUND: Deformable image registration (DIR)-based lung ventilation mapping is attractive due to its simplicity, and also challenging due to its susceptibility to errors and uncertainties. In this study, we explored the use of 3D Hyperpolarized (HP) gas ... Full text Link to item Cite

Association of Interim FDG-PET Imaging During Chemoradiation for Squamous Anal Canal Carcinoma With Recurrence.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2018 PURPOSE: Imaging parameters from 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) before and after chemoradiation therapy (CRT) for anal canal cancer correlate with clinical outcomes. This prospective, hypothesis-generating pilot study inv ... Full text Link to item Cite

Spatial-temporal variability of radiomic features and its effect on the classification of lung cancer histology.

Journal Article Phys Med Biol · November 8, 2018 The purpose of this research was to study the sensitivity of Computed Tomography (CT) radiomic features to motion blurring and signal-to-noise ratios (SNR), and investigate its downstream effect regarding the classification of non-small cell lung cancer (N ... Full text Open Access Link to item Cite

Effect of machine learning methods on predicting NSCLC overall survival time based on Radiomics analysis.

Journal Article Radiat Oncol · October 5, 2018 BACKGROUND: To investigate the effect of machine learning methods on predicting the Overall Survival (OS) for non-small cell lung cancer based on radiomics features analysis. METHODS: A total of 339 radiomic features were extracted from the segmented tumor ... Full text Open Access Link to item Cite

Lung IMRT planning with automatic determination of beam angle configurations.

Journal Article Phys Med Biol · July 6, 2018 Beam angle configuration is a major planning decision in intensity modulated radiation treatment (IMRT) that has a significant impact on dose distributions and thus quality of treatment, especially in complex planning cases such as those for lung cancer tr ... Full text Link to item Cite

Iterative inversion of deformation vector fields with feedback control.

Journal Article Med Phys · July 2018 PURPOSE: Often, the inverse deformation vector field (DVF) is needed together with the corresponding forward DVF in four-dimesional (4D) reconstruction and dose calculation, adaptive radiation therapy, and simultaneous deformable registration. This study a ... Full text Link to item Cite

A Novel method to generate on-board 4D MRI using prior 4D MRI and on-board kV projections from a conventional LINAC for target localization in liver SBRT.

Journal Article Med Phys · July 2018 PURPOSE: On-board MRI can provide superb soft tissue contrast for improving liver SBRT localization. However, the availability of on-board MRI in clinics is extremely limited. On the contrary, on-board kV imaging systems are widely available on radiotherap ... Full text Link to item Cite

Advances in Patient Setup and Target Localization

Chapter · May 24, 2018 This new book educates readers about new technologies before they appear in hospitals, enabling medical physicists and clinicians to prepare for new technologies thoroughly and proactively, and provide better patient care once new equipment ... ... Cite

Low dose CBCT reconstruction via prior contour based total variation (PCTV) regularization: a feasibility study.

Journal Article Phys Med Biol · April 19, 2018 PURPOSE: compressed sensing reconstruction using total variation (TV) tends to over-smooth the edge information by uniformly penalizing the image gradient. The goal of this study is to develop a novel prior contour based TV (PCTV) method to enhance the edg ... Full text Link to item Cite

Improving Quality and Consistency in NRG Oncology Radiation Therapy Oncology Group 0631 for Spine Radiosurgery via Knowledge-Based Planning.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2018 PURPOSE: To use knowledge-based planning (KBP) as a method of producing high-quality, consistent, protocol-compliant treatment plans in a complex setting of spine stereotactic body radiation therapy on NRG Oncology Radiation Therapy Oncology Group (RTOG) 0 ... Full text Link to item Cite

Application of the 4-D XCAT Phantoms in Biomedical Imaging and Beyond.

Journal Article IEEE Trans Med Imaging · March 2018 The four-dimensional (4-D) eXtended CArdiac-Torso (XCAT) series of phantoms was developed to provide accurate computerized models of the human anatomy and physiology. The XCAT series encompasses a vast population of phantoms of varying ages from newborn to ... Full text Link to item Cite

Image acquisition optimization of a limited-angle intrafraction verification (LIVE) system for lung radiotherapy.

Journal Article Med Phys · January 2018 PURPOSE: Limited-angle intrafraction verification (LIVE) has been previously developed for four-dimensional (4D) intrafraction target verification either during arc delivery or between three-dimensional (3D)/IMRT beams. Preliminary studies showed that LIVE ... Full text Link to item Cite

Principal component reconstruction (PCR) for cine CBCT with motion learning from 2D fluoroscopy.

Journal Article Med Phys · January 2018 PURPOSE: This work aims to generate cine CT images (i.e., 4D images with high-temporal resolution) based on a novel principal component reconstruction (PCR) technique with motion learning from 2D fluoroscopic training images. METHODS: In the proposed PCR m ... Full text Link to item Cite

An Ensemble Approach to Knowledge-Based Intensity-Modulated Radiation Therapy Planning.

Journal Article Front Oncol · 2018 Knowledge-based planning (KBP) utilizes experienced planners' knowledge embedded in prior plans to estimate optimal achievable dose volume histogram (DVH) of new cases. In the regression-based KBP framework, previously planned patients' anatomical features ... Full text Open Access Link to item Cite

Assessment of concurrent stereotactic radiosurgery and bevacizumab treatment of recurrent malignant gliomas using multi-modality MRI imaging and radiomics analysis.

Journal Article J Radiosurg SBRT · 2018 PURPOSE: To assess the response and predict the overall survival (OS) of recurrent malignant gliomas (MG) patients treated with concurrent BVZ/SRS using multi-modality MRI imaging and radiomics analysis.Methods and materials: SRS was delivered in a single ... Link to item Cite

Dosimetric Characterization of an Intensity-modulated X-Ray Brachytherapy System.

Journal Article J Med Phys · 2018 PURPOSE: An intensity-modulated X-ray brachytherapy system is being developed for various clinical applications. This new system makes it possible for clinical staff to control energy as well as dose rate for different tumor sites according to their sizes ... Full text Link to item Cite

Accelerating volumetric cine MRI (VC-MRI) using undersampling for real-time 3D target localization/tracking in radiation therapy: a feasibility study.

Journal Article Phys Med Biol · December 14, 2017 PURPOSE: To accelerate volumetric cine MRI (VC-MRI) using undersampled 2D-cine MRI to provide real-time 3D guidance for gating/target tracking in radiotherapy. METHODS: 4D-MRI is acquired during patient simulation. One phase of the prior 4D-MRI is selected ... Full text Link to item Cite

Clinical Study of Orthogonal-View Phase-Matched Digital Tomosynthesis for Lung Tumor Localization.

Journal Article Technol Cancer Res Treat · December 2017 BACKGROUND AND PURPOSE: Compared to cone-beam computed tomography, digital tomosynthesis imaging has the benefits of shorter scanning time, less imaging dose, and better mechanical clearance for tumor localization in radiation therapy. However, for lung tu ... Full text Link to item Cite

Characterization of Water-Clear Polymeric Gels for Use as Radiotherapy Bolus.

Journal Article Technol Cancer Res Treat · December 2017 Our purpose was to investigate polymeric gels for use as a highly transparent radiotherapy bolus and determine the relevant physical and dosimetric properties. We first quantified tensile properties (maximum stress, strain, and Young modulus) for various p ... Full text Link to item Cite

Development of a Computerized 4-D MRI Phantom for Liver Motion Study.

Journal Article Technol Cancer Res Treat · December 2017 PURPOSE: To develop a 4-dimensional computerized magnetic resonance imaging phantom with image textures extracted from real patient scans for liver motion studies. METHODS: The proposed phantom was developed based on the current version of 4-dimensional ex ... Full text Link to item Cite

Dosimetric Analysis of Microscopic Disease in SBRT for Lung Cancers.

Journal Article Technol Cancer Res Treat · December 2017 OBJECTIVE: The objective of this study is to theoretically and experimentally evaluate the dosimetry in the microscopic disease regions surrounding the tumor under stereotactic body radiation therapy of lung cancer. METHODS: For simplicity, the tumor was c ... Full text Link to item Cite

Outlier identification in radiation therapy knowledge-based planning: A study of pelvic cases.

Journal Article Med Phys · November 2017 PURPOSE: The purpose of this study was to apply statistical metrics to identify outliers and to investigate the impact of outliers on knowledge-based planning in radiation therapy of pelvic cases. We also aimed to develop a systematic workflow for identify ... Full text Link to item Cite

Biopsy of enlarging lesions after stereotactic radiosurgery for brain metastases frequently reveals radiation necrosis.

Journal Article Neuro Oncol · October 1, 2017 BACKGROUND: Stereotactic radiosurgery (SRS) offers excellent local control for brain metastases (BM) with low rates of toxicity. Radiation necrosis (RN) may occur after treatment and is challenging to distinguish from local recurrence (LR). We evaluated en ... Full text Link to item Cite

AAPM-RSS Medical Physics Practice Guideline 9.a. for SRS-SBRT.

Journal Article J Appl Clin Med Phys · September 2017 The American Association of Physicists in Medicine (AAPM) is a nonprofit professional society whose primary purposes are to advance the science, education, and professional practice of medical physics. The AAPM has more than 8,000 members and is the princi ... Full text Link to item Cite

Respiratory signal prediction based on adaptive boosting and multi-layer perceptron neural network.

Journal Article Phys Med Biol · August 3, 2017 To improve the prediction accuracy of respiratory signals using adaptive boosting and multi-layer perceptron neural network (ADMLP-NN) for gated treatment of moving target in radiation therapy. The respiratory signals acquired using a real-time position ma ... Full text Link to item Cite

Accelerated Brain DCE-MRI Using Iterative Reconstruction With Total Generalized Variation Penalty for Quantitative Pharmacokinetic Analysis: A Feasibility Study.

Journal Article Technol Cancer Res Treat · August 2017 PURPOSE: To investigate the feasibility of using undersampled k-space data and an iterative image reconstruction method with total generalized variation penalty in the quantitative pharmacokinetic analysis for clinical brain dynamic contrast-enhanced magne ... Full text Link to item Cite

Exploring the Margin Recipe for Online Adaptive Radiation Therapy for Intermediate-Risk Prostate Cancer: An Intrafractional Seminal Vesicles Motion Analysis.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2017 PURPOSE: To provide a benchmark for seminal vesicle (SV) margin selection to account for intrafractional motion and to investigate the effectiveness of 2 motion surrogates in predicting intrafractional SV coverage. METHODS AND MATERIALS: Fifteen prostate p ... Full text Link to item Cite

Reducing scan angle using adaptive prior knowledge for a limited-angle intrafraction verification (LIVE) system for conformal arc radiotherapy.

Journal Article Phys Med Biol · May 7, 2017 The purpose of this study is to develop an adaptive prior knowledge guided image estimation technique to reduce the scan angle needed in the limited-angle intrafraction verification (LIVE) system for 4D-CBCT reconstruction. The LIVE system has been previou ... Full text Link to item Cite

Quantitative Approach to Failure Mode and Effect Analysis for Linear Accelerator Quality Assurance.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2017 PURPOSE: To determine clinic-specific linear accelerator quality assurance (QA) TG-142 test frequencies, to maximize physicist time efficiency and patient treatment quality. METHODS AND MATERIALS: A novel quantitative approach to failure mode and effect an ... Full text Link to item Cite

Retrospective four-dimensional magnetic resonance imaging with image-based respiratory surrogate: a sagittal-coronal-diaphragm point of intersection motion tracking method.

Journal Article J Med Imaging (Bellingham) · April 2017 A four-dimensional magnetic resonance imaging (4-D-MRI) technique with Sagittal-Coronal-Diaphragm Point-of-Intersection (SCD-PoI) as a respiratory surrogate is proposed. To develop an image-based respiratory surrogate, the SCD-PoI motion tracking method is ... Full text Link to item Cite

Estimating 4D-CBCT from prior information and extremely limited angle projections using structural PCA and weighted free-form deformation for lung radiotherapy.

Journal Article Med Phys · March 2017 PURPOSE: To investigate the feasibility of using structural-based principal component analysis (PCA) motion-modeling and weighted free-form deformation to estimate on-board 4D-CBCT using prior information and extremely limited angle projections for potenti ... Full text Link to item Cite

Four-dimensional diffusion-weighted MR imaging (4D-DWI): a feasibility study.

Journal Article Med Phys · February 2017 PURPOSE: Diffusion-weighted Magnetic Resonance Imaging (DWI) has been shown to be a powerful tool for cancer detection with high tumor-to-tissue contrast. This study aims to investigate the feasibility of developing a four-dimensional DWI technique (4D-DWI ... Full text Link to item Cite

Impact of moving target on measurement accuracy in 3D and 4D PET imaging-a phantom study.

Journal Article Adv Radiat Oncol · 2017 PURPOSE: The purpose of this study was to evaluate the impact of tumor motion on maximum standardized uptake value (SUVmax) and metabolic tumor volume (MTV) measurements in both 3-dimensional and respiratory-correlated, 4-dimensional positron emission tomo ... Full text Link to item Cite

An in-house protocol for improved flood field calibration of TrueBeam FFF cine imaging.

Journal Article J Appl Clin Med Phys · January 2017 PURPOSE: TrueBeams equipped with the 40 × 30 cm2 Electronic Portal Imaging Devices (EPIDs) are prone to image saturation at the image center when used with flattening filter free (FFF) photon energies. While cine imaging during treatment may not saturate b ... Full text Link to item Cite

Single fraction stereotactic radiosurgery for multiple brain metastases.

Journal Article Adv Radiat Oncol · 2017 INTRODUCTION: Due to the neurocognitive side effects of whole brain radiation therapy (WBRT), stereotactic radiosurgery (SRS) is being used with increasing frequency. The use of SRS is expanding for patients with multiple (>4) brain metastases (BM). This s ... Full text Open Access Link to item Cite

High-resolution imaging immunolabeled large tissues

Conference Optics InfoBase Conference Papers · January 1, 2017 We combined large sample resin embedding with immunofluorescence staining to acquire biomolecules profiles with high spatial-resolution. After evaluating the compatibility of this method and filtering embedding resin, we achieved to high-resolution image i ... Full text Cite

A simple, rapid method to precisely locate mRNAs of intact mouse brain via fluorescence tomography

Conference Optics InfoBase Conference Papers · January 1, 2017 To precisely locate mRNAs of mouse brain, a simple, rapid method was developed via combining whole mount in situ hybridization and fluorescence tomography, with cytoarchitectonic landmarks provided by propidium iodide real-time counterstaining during the i ... Full text Cite

Markerless Four-Dimensional-Cone Beam Computed Tomography Projection-Phase Sorting Using Prior Knowledge and Patient Motion Modeling: A Feasibility Study.

Journal Article Cancer Transl Med · 2017 AIM: During cancer radiotherapy treatment, on-board four-dimensional-cone beam computed tomography (4D-CBCT) provides important patient 4D volumetric information for tumor target verification. Reconstruction of 4D-CBCT images requires sorting of acquired p ... Open Access Link to item Cite

Sensitivity of 3D Dose Verification to Multileaf Collimator Misalignments in Stereotactic Body Radiation Therapy of Spinal Tumor.

Journal Article Technol Cancer Res Treat · December 2016 PURPOSE: This study aimed to detect the sensitivity of Delt 4 on ordinary field multileaf collimator misalignments, system misalignments, random misalignments, and misalignments caused by gravity of the multileaf collimator in stereotactic body radiation t ... Full text Link to item Cite

A probability-based multi-cycle sorting method for 4D-MRI: A simulation study.

Journal Article Med Phys · December 2016 PURPOSE: To develop a novel probability-based sorting method capable of generating multiple breathing cycles of 4D-MRI images and to evaluate performance of this new method by comparing with conventional phase-based methods in terms of image quality and tu ... Full text Link to item Cite

Comparisons of volumetric modulated arc therapy (VMAT) quality assurance (QA) systems: sensitivity analysis to machine errors.

Journal Article Radiat Oncol · November 7, 2016 BACKGROUND: In volumetric modulated arc therapy (VMAT), gantry angles, dose rate and the MLC positions vary with the radiation delivery. The quality assurance (QA) system should be able to catch the planning and machine errors. The aim of this study was to ... Full text Open Access Link to item Cite

Assessment of Treatment Response With Diffusion-Weighted MRI and Dynamic Contrast-Enhanced MRI in Patients With Early-Stage Breast Cancer Treated With Single-Dose Preoperative Radiotherapy: Initial Results.

Journal Article Technol Cancer Res Treat · October 2016 Single-dose preoperative stereotactic body radiotherapy is a novel radiotherapy technique for the early-stage breast cancer, and the treatment response pattern of this technique needs to be investigated on a quantitative basis. In this work, dynamic contra ... Full text Link to item Cite

Simultaneous 4D-CBCT reconstruction with sliding motion constraint.

Journal Article Med Phys · October 2016 PURPOSE: Current approaches using deformable vector field (DVF) for motion-compensated 4D-cone beam CT (CBCT) reconstruction typically utilize an isotropically smoothed DVF between different respiration phases. Such isotropically smoothed DVF does not work ... Full text Link to item Cite

Re-examining TG-142 recommendations in light of modern techniques for linear accelerator based radiosurgery.

Journal Article Med Phys · October 2016 PURPOSE: The recent development of multifocal stereotactic radiosurgery (SRS) using a single isocenter volumetric modulated arc theory (VMAT) technique warrants a re-examination of the quality assurance (QA) tolerances for routine mechanical QA recommended ... Full text Link to item Cite

Diode-based transmission detector for IMRT delivery monitoring: a validation study.

Journal Article J Appl Clin Med Phys · September 8, 2016 The purpose of this work was to evaluate the potential of a new transmission detector for real-time quality assurance of dynamic-MLC-based radiotherapy. The accuracy of detecting dose variation and static/dynamic MLC position deviations was measured, as we ... Full text Open Access Link to item Cite

Diode-based transmission detector for IMRT delivery monitoring: a validation study.

Journal Article J Appl Clin Med Phys · September 2016 The purpose of this work was to evaluate the potential of a new transmission detector for real-time quality assurance of dynamic-MLC-based radiotherapy. The accuracy of detecting dose variation and static/dynamic MLC position deviations was measured, as we ... Full text Link to item Cite

Evaluation of the effect of transcytolemmal water exchange analysis for therapeutic response assessment using DCE-MRI: a comparison study.

Journal Article Phys Med Biol · July 7, 2016 This study compares the shutter-speed (SS) and the Tofts models as used in assessing therapeutic response in a longitudinal DCE-MRI experiment. Sixteen nu/nu mice with implanted colorectal adenocarcinoma cell line (LS-174T) were randomly assigned into trea ... Full text Link to item Cite

Scatter Reduction and Correction for Dual-Source Cone-Beam CT Using Prepatient Grids.

Journal Article Technol Cancer Res Treat · June 2016 PURPOSE: Scatter significantly limits the application of the dual-source cone-beam computed tomography by inducing scatter artifacts and degrading contrast-to-noise ratio, Hounsfield-unit accuracy, and image uniformity. Although our previously developed in ... Full text Link to item Cite

A Technique for Generating Volumetric Cine-Magnetic Resonance Imaging.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2016 PURPOSE: The purpose of this study was to develop a techique to generate on-board volumetric cine-magnetic resonance imaging (VC-MRI) using patient prior images, motion modeling, and on-board 2-dimensional cine MRI. METHODS AND MATERIALS: One phase of a 4- ... Full text Link to item Cite

Dynamic fractal signature dissimilarity analysis for therapeutic response assessment using dynamic contrast-enhanced MRI.

Journal Article Med Phys · March 2016 PURPOSE: To develop a dynamic fractal signature dissimilarity (FSD) method as a novel image texture analysis technique for the quantification of tumor heterogeneity information for better therapeutic response assessment with dynamic contrast-enhanced (DCE) ... Full text Link to item Cite

An efficient calculation method for pharmacokinetic parameters in brain permeability study using dynamic contrast-enhanced MRI.

Journal Article Magn Reson Med · February 2016 PURPOSE: To develop an efficient method for calculating pharmacokinetic (PK) parameters in brain DCE-MRI permeability studies. METHODS: A linear least-squares fitting algorithm based on a derivative expression of the two-compartment PK model was proposed t ... Full text Link to item Cite

On the sensitivity of TG-119 and IROC credentialing to TPS commissioning errors.

Journal Article J Appl Clin Med Phys · January 8, 2016 We investigate the sensitivity of IMRT commissioning using the TG-119 C-shape phantom and credentialing with the IROC head and neck phantom to treatment planning system commissioning errors. We introduced errors into the various aspects of the commissionin ... Full text Open Access Link to item Cite

Physics considerations for single-isocenter, volumetric modulated arc radiosurgery for treatment of multiple intracranial targets.

Conference Pract Radiat Oncol · 2016 OBJECTIVE: Our purpose was to address challenges associated with single-isocenter radiosurgery for multiple intracranial targets (SIRMIT) including increased sensitivity to rotational uncertainties (resulting from distance of the targets from isocenter) as ... Full text Link to item Cite

Accuracy of respiratory motion measurement of 4D-MRI: A comparison between cine and sequential acquisition.

Journal Article Med Phys · January 2016 PURPOSE: The authors have recently developed a cine-mode T2*/T1-weighted 4D-MRI technique and a sequential-mode T2-weighted 4D-MRI technique for imaging respiratory motion. This study aims at investigating which 4D-MRI image acquisition mode, cine or seque ... Full text Link to item Cite

On the sensitivity of TG-119 and IROC credentialing to TPS commissioning errors.

Journal Article J Appl Clin Med Phys · January 2016 We investigate the sensitivity of IMRT commissioning using the TG-119 C-shape phantom and credentialing with the IROC head and neck phantom to treatment planning system commissioning errors. We introduced errors into the various aspects of the commissionin ... Full text Link to item Cite

Atlas-guided prostate intensity modulated radiation therapy (IMRT) planning.

Journal Article Phys Med Biol · September 21, 2015 An atlas-based IMRT planning technique for prostate cancer was developed and evaluated. A multi-dose atlas was built based on the anatomy patterns of the patients, more specifically, the percent distance to the prostate and the concaveness angle formed by ... Full text Link to item Cite

T2-weighted four dimensional magnetic resonance imaging with result-driven phase sorting.

Journal Article Med Phys · August 2015 PURPOSE: T2-weighted MRI provides excellent tumor-to-tissue contrast for target volume delineation in radiation therapy treatment planning. This study aims at developing a novel T2-weighted retrospective four dimensional magnetic resonance imaging (4D-MRI) ... Full text Link to item Cite

Dosimetric verification of lung cancer treatment using the CBCTs estimated from limited-angle on-board projections.

Journal Article Med Phys · August 2015 PURPOSE: Lung cancer treatment is susceptible to treatment errors caused by interfractional anatomical and respirational variations of the patient. On-board treatment dose verification is especially critical for the lung stereotactic body radiation therapy ... Full text Link to item Cite

Utilizing knowledge from prior plans in the evaluation of quality assurance.

Journal Article Phys Med Biol · June 21, 2015 Increased interest regarding sensitivity of pre-treatment intensity modulated radiotherapy and volumetric modulated arc radiotherapy (VMAT) quality assurance (QA) to delivery errors has led to the development of dose-volume histogram (DVH) based analysis. ... Full text Link to item Cite

TH-CD-207-09: Retrospective 4D-MRI with a Novel Image-Based Surrogate: A Sagittal-Coronal-Diaphragm Point of Intersection (SCD-PoI) Motion Tracking Method.

Journal Article Med Phys · June 2015 PURPOSE: The unreliable stability of internal respiratory surrogates and inconvenience of external respiratory surrogates for current retrospective 4D-MRI techniques largely affects the image quality of 4D-MRI. This study aims at developing image-based sur ... Full text Link to item Cite

TH-CD-204-10: Probability-Driven Sorting Method for Reconstructing Variation-Independent 4D-MRI.

Journal Article Med Phys · June 2015 PURPOSE: To develop a novel probability-driven sorting method that inherently incorporates breathing variations in the sorting process and 4D reconstruction. METHODS: The probability-driven sorting method has two key steps: (a) determination of multiple pr ... Full text Link to item Cite

TH-CD-204-09: Physiological Modeling of Lung Motion Based On Hyperpolarized Gas Tagging MRI.

Journal Article Med Phys · June 2015 PURPOSE: To model the respiratory motion of lung based on the physiological ground truth measured with hyperpolarized (HP) gas tagging magnetic resonance imaging (MRI). METHODS: A novel 4D model was established to investigate the respiratory motion of lung ... Full text Link to item Cite

WE-AB-BRA-11: Development of Physiological-Based Virtual Thorax Phantoms for Evaluation of Deformable Image Registration.

Journal Article Med Phys · June 2015 PURPOSE: To develop a methodology of constructing physiological-based virtual thorax phantom based on hyperpolarized (HP) gas tagging MRI for evaluating deformable image registration (DIR). METHODS: Three healthy subjects were imaged at both the end-of-inh ... Full text Link to item Cite

WE-G-BRD-06: Volumetric Cine MRI (VC-MRI) Estimated Based On Prior Knowledge for On-Board Target Localization.

Conference Med Phys · June 2015 PURPOSE: To develop a technique to generate on-board VC-MRI using patient prior 4D-MRI, motion modeling and on-board 2D-cine MRI for real-time 3D target verification of liver and lung radiotherapy. METHODS: The end-expiration phase images of a 4D-MRI acqui ... Full text Link to item Cite

WE-AB-BRA-03: Displacement Vector Field (DVF) Error Correction Using Sparsely Distributed Ground-Truth Displacement Vectors.

Journal Article Med Phys · June 2015 PURPOSE: This study aims to develop a technique capable of reducing errors in deformable image registration (DIR) by integrating information of sparsely distributed ground-truth displacement vectors into a dense DVF. METHODS: An in-house developed lung mot ... Full text Link to item Cite

SU-E-J-223: A BOLD Contrast Imaging Sequence to Evaluate Oxygenation Changes Due to Breath Holding for Breast Radiotherapy: A Pilot Study.

Journal Article Med Phys · June 2015 PURPOSE: To develop a robust MRI sequence to measure BOLD breath hold induced contrast in context of breast radiotherapy. METHODS: Two sequences were selected from prior studies as candidates to measure BOLD contrast attributable to breath holding within t ... Full text Link to item Cite

SU-D-BRA-01: Therapeutic Response Assessment Using a Novel Gray Level Local Power Matrix (GLLPM) in DCE-MRI Texture Analysis: Feasibility Study.

Journal Article Med Phys · June 2015 PURPOSE: Most current DCE-MRI texture analysis methods focus on the spatial information of chosen contrast-enhanced MR volumes or pharmacokinetic (PK) parameter maps, and the temporal information is not well included. This work proposed a novel texture mat ... Full text Link to item Cite

TU-AB-303-06: Does Online Adaptive Radiation Therapy Mean Zero Margin for Intermediate-Risk Prostate Cancer? An Intra-Fractional Seminal Vesicles Motion Analysis.

Journal Article Med Phys · June 2015 PURPOSE: To provide benchmark for seminal vesicles (SVs) margin selection to account for intra-fractional motion; and to investigate the effectiveness of two motion surrogates in predicting intra-fractional SV underdosage. METHODS: 9 prostate SBRT patients ... Full text Link to item Cite

TH-CD-303-06: Deformable Registration-Based Image Estimation Method for 4D CBCT Using Region-Based PCA.

Conference Med Phys · June 2015 PURPOSE: To investigate the feasibility of using region-based principal component analysis (PCA) for motion modeling to estimate on-board 4D-CBCT using prior information and limited angle projections for potential 4D target verification of lung radiotherap ... Full text Link to item Cite

TH-AB-303-02: An Investigation of Respiratory Signal Parameters for Multiple-Step Ahead Prediction of Surrogate Motion.

Conference Med Phys · June 2015 PURPOSE: Target tracking or gating the radiation beam using real-time imaging and surrogate motion monitoring methods are employed for dynamic tracking treatment or respiratory-gated radiotherapy. This method requires tumor motion prediction far enough in ... Full text Link to item Cite

WE-D-303-05: Dosimetric Accuracy of CBCT Images Estimated by a Motion Modeling and Free-Form Deformation Technique for Radiotherapy of Lung Cancer.

Conference Med Phys · June 2015 PURPOSE: To investigate the dosimetric accuracy of CBCTs estimated by a motion modeling and free-form deformation(MM-FD) technique for radiotherapy of lung cancer. METHODS: Various inter-fractional variations featuring patient motion pattern change, tumor ... Full text Link to item Cite

WE-AB-303-09: Rapid Projection Computations for On-Board Digital Tomosynthesis in Radiation Therapy.

Conference Med Phys · June 2015 PURPOSE: To facilitate fast and accurate iterative volumetric image reconstruction from limited-angle on-board projections. METHODS: Intrafraction motion hinders the clinical applicability of modern radiotherapy techniques, such as lung stereotactic body r ... Full text Link to item Cite

SU-E-T-293: Dosimetric Analysis of Microscopic Disease in SBRT for Lung Cancers.

Conference Med Phys · June 2015 PURPOSE: To evaluate the dosimetry of microscopic disease (MD) region of lung cancer in stereotactic body radiation therapy (SBRT). METHODS: For simplicity, we assume organ moves along one dimension. The probability distribution function of tumor position ... Full text Link to item Cite

SU-E-J-26: A Novel Technique for Markerless Self-Sorted 4D-CBCT Using Patient Motion Modeling: A Feasibility Study.

Conference Med Phys · June 2015 PURPOSE: To develop an automatic markerless 4D-CBCT projection sorting technique by using a patient respiratory motion model extracted from the planning 4D-CT images. METHODS: Each phase of onboard 4D-CBCT is considered as a deformation of one phase of the ... Full text Link to item Cite

SU-E-I-40: Phantom Research On Monochromatic Images Taken by Dual CBCT with Multiple Energy Sets.

Conference Med Phys · June 2015 PURPOSE: To evaluate the quality of monochromatic images at the same virtual monochromatic energy using dual cone-beam computed tomography (CBCT) with either kV/kV or MV/kV or MV/MV energy sets. METHODS: CT images of Catphan 504 phantom were acquired using ... Full text Link to item Cite

SU-E-T-690: Sensitivity Analysis to Machine Error: Comparisons of VMAT QA Systems.

Journal Article Med Phys · June 2015 PURPOSE: In VMAT delivery, the gantry angles, dose rate and the MLC positions are all modulated. It is therefore necessary to perform pre-treatment QA to detect any possible errors either in the plan or machine delivery system. Previously we developed a QA ... Full text Link to item Cite

MO‐G‐304‐03: Development of Knowledge Models for IMRT Treatment Planning Utilizing a Rapid Learning Approach

Conference Medical Physics · June 2015 Purpose:We present an implementation of the knowledge‐based planning method utilizing a rapid learning approach which enables the accurate evolution of models as new data are collected during daily clinical practi ... Full text Cite

Flattening filter-free accelerators: a report from the AAPM Therapy Emerging Technology Assessment Work Group.

Journal Article J Appl Clin Med Phys · May 8, 2015 This report describes the current state of flattening filter-free (FFF) radiotherapy beams implemented on conventional linear accelerators, and is aimed primarily at practicing medical physicists. The Therapy Emerging Technology Assessment Work Group of th ... Full text Open Access Link to item Cite

A Monte Carlo simulation framework for electron beam dose calculations using Varian phase space files for TrueBeam Linacs.

Journal Article Med Phys · May 2015 PURPOSE: To develop a framework for accurate electron Monte Carlo dose calculation. In this study, comprehensive validations of vendor provided electron beam phase space files for Varian TrueBeam Linacs against measurement data are presented. METHODS: In t ... Full text Link to item Cite

Preliminary clinical evaluation of a 4D-CBCT estimation technique using prior information and limited-angle projections.

Journal Article Radiother Oncol · April 2015 BACKGROUND AND PURPOSE: A technique has been previously reported to estimate high-quality 4D-CBCT using prior information and limited-angle projections. This study is to investigate its clinical feasibility through both phantom and patient studies. MATERIA ... Full text Link to item Cite

Quantitative comparison of automatic and manual IMRT optimization for prostate cancer: the benefits of DVH prediction.

Journal Article J Appl Clin Med Phys · March 8, 2015 A recent publication indicated that the patient anatomical feature (PAF) model was capable of predicting optimal objectives based on past experience. In this study, the benefits of IMRT optimization using PAF-predicted objectives as guidance for prostate w ... Full text Open Access Link to item Cite

Standardized beam bouquets for lung IMRT planning.

Journal Article Phys Med Biol · March 7, 2015 The selection of the incident angles of the treatment beams is a critical component of intensity modulated radiation therapy (IMRT) planning for lung cancer due to significant variations in tumor location, tumor size and patient anatomy. We investigate the ... Full text Link to item Cite

From active shape model to active optical flow model: a shape-based approach to predicting voxel-level dose distributions in spine SBRT.

Journal Article Phys Med Biol · March 7, 2015 Prediction of achievable dose distribution in spine stereotactic body radiation therapy (SBRT) can help in designing high-quality treatment plans to maximally protect spinal cords and to effectively control tumours. Dose distributions at spinal cords are p ... Full text Link to item Cite

Four dimensional magnetic resonance imaging with retrospective k-space reordering: a feasibility study.

Journal Article Med Phys · February 2015 PURPOSE: Current four dimensional magnetic resonance imaging (4D-MRI) techniques lack sufficient temporal/spatial resolution and consistent tumor contrast. To overcome these limitations, this study presents the development and initial evaluation of a new s ... Full text Link to item Cite

Dosimetric comparison of preoperative single-fraction partial breast radiotherapy techniques: 3D CRT, noncoplanar IMRT, coplanar IMRT, and VMAT.

Journal Article J Appl Clin Med Phys · January 8, 2015 The purpose of this study was to compare dosimetric parameters of treatment plans among four techniques for preoperative single-fraction partial breast radiotherapy in order to select an optimal treatment technique. The techniques evaluated were noncoplana ... Full text Link to item Cite

Impact of dose calculation accuracy during optimization on lung IMRT plan quality.

Journal Article J Appl Clin Med Phys · January 8, 2015 The purpose of this study was to evaluate the effect of dose calculation accuracy and the use of an intermediate dose calculation step during the optimization of intensity-modulated radiation therapy (IMRT) planning on the final plan quality for lung cance ... Full text Link to item Cite

Defining the optimal planning target volume in image-guided stereotactic radiosurgery of brain metastases: results of a randomized trial.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2015 PURPOSE: To identify an optimal margin about the gross target volume (GTV) for stereotactic radiosurgery (SRS) of brain metastases, minimizing toxicity and local recurrence. METHODS AND MATERIALS: Adult patients with 1 to 3 brain metastases less than 4 cm ... Full text Link to item Cite

Quality assurance for online adapted treatment plans: benchmarking and delivery monitoring simulation.

Journal Article Med Phys · January 2015 PURPOSE: An important challenge facing online adaptive radiation therapy is the development of feasible and efficient quality assurance (QA). This project aimed to validate the deliverability of online adapted plans and develop a proof-of-concept online de ... Full text Link to item Cite

Dosimetric comparison of preoperative single-fraction partial breast radiotherapy techniques: 3D CRT, noncoplanar IMRT, coplanar IMRT, and VMAT

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2015 The purpose of this study was to compare dosimetric parameters of treatment plans among four techniques for preoperative single-fraction partial breast radiotherapy in order to select an optimal treatment technique. The techniques evaluated were noncoplana ... Cite

An active optical flow model for dose prediction in spinal sbrt plans

Journal Article Lecture Notes in Computational Vision and Biomechanics · January 1, 2015 Accurate dose predication is critical to spinal stereotactic body radiation therapy (SBRT). It enables radiation oncologists and planners to design treatment plans that maximally protect spinal cord while effectively controlling surrounding tumors. Spinal ... Full text Cite

Quantitative comparison of automatic and manual IMRT optimization for prostate cancer: The benefits of DVH prediction

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2015 A recent publication indicated that the patient anatomical feature (PAF) model was capable of predicting optimal objectives based on past experience. In this study, the benefits of IMRT optimization using PAF-predicted objectives as guidance for prostate w ... Full text Cite

Knowledge modeling for computer aided treatment planning

Conference IFMBE Proceedings · January 1, 2015 The purpose for this study is to develop robust and comprehensive knowledge models which can provide patient specific prediction of achievable dose distribution in radiation therapy plans for a wide range of cancer types. These models are useful tools to g ... Full text Cite

Knowledge based automatic beam angle determination for lung IMRT planning

Conference IFMBE Proceedings · January 1, 2015 We present an efficient knowledge based automatic beam configuration determination method by utilizing patient-specific anatomy and tumor geometry information and a beam bouquet atlas. The proposed technique is based on learning the relationship between pa ... Full text Cite

A rapid learning approach for the knowledge modeling of radiation therapy plan

Conference IFMBE Proceedings · January 1, 2015 The purpose of this study is to implement a rapid learning method to train the knowledge models to predict the organ-at-risk (OAR) dose sparing in radiation therapy (RT) based on an array of patient anatomical features. We also aim to establish the evaluat ... Full text Cite

Is diaphragm motion a good surrogate for liver tumor motion?

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2014 PURPOSE: To evaluate the relationship between liver tumor motion and diaphragm motion. METHODS AND MATERIALS: Fourteen patients with hepatocellular carcinoma (10 of 14) or liver metastases (4 of 14) undergoing radiation therapy were included in this study. ... Full text Link to item Cite

A hardware investigation of robotic SPECT for functional and molecular imaging onboard radiation therapy systems.

Journal Article Med Phys · November 2014 PURPOSE: To construct a robotic SPECT system and to demonstrate its capability to image a thorax phantom on a radiation therapy flat-top couch, as a step toward onboard functional and molecular imaging in radiation therapy. METHODS: A robotic SPECT imaging ... Full text Link to item Cite

Investigation of sagittal image acquisition for 4D-MRI with body area as respiratory surrogate.

Journal Article Med Phys · October 2014 PURPOSE: The authors have recently developed a novel 4D-MRI technique for imaging organ respiratory motion employing cine acquisition in the axial plane and using body area (BA) as a respiratory surrogate. A potential disadvantage associated with axial ima ... Full text Link to item Cite

Automatic Determination of Beam Angles in Lung IMRT Planning

Conference International Journal of Radiation Oncology*Biology*Physics · September 2014 Full text Cite

On the feasibility of polyurethane based 3D dosimeters with optical CT for dosimetric verification of low energy photon brachytherapy seeds.

Journal Article Med Phys · July 2014 PURPOSE: To investigate the feasibility of and challenges yet to be addressed to measure dose from low energy (effective energy <50 keV) brachytherapy sources (Pd-103, Cs-131, and I-125) using polyurethane based 3D dosimeters with optical CT. METHODS: The ... Full text Link to item Cite

Review of treatment assessment using DCE-MRI in breast cancer radiation therapy.

Journal Article World J Methodol · June 26, 2014 As a noninvasive functional imaging technique, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is being used in oncology to measure properties of tumor microvascular structure and permeability. Studies have shown that parameters derived from ... Full text Link to item Cite

Stereotactic body radiotherapy: a critical review for nonradiation oncologists.

Journal Article Cancer · April 1, 2014 Stereotactic body radiotherapy (SBRT) involves the treatment of extracranial primary tumors or metastases with a few, high doses of ionizing radiation. In SBRT, tumor kill is maximized and dose to surrounding tissue is minimized, by precise and accurate de ... Full text Link to item Cite

Four-dimensional magnetic resonance imaging using axial body area as respiratory surrogate: initial patient results.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2014 PURPOSE: To evaluate the feasibility of a retrospective binning technique for 4-dimensional magnetic resonance imaging (4D-MRI) using body area (BA) as a respiratory surrogate. METHODS AND MATERIALS: Seven patients with hepatocellular carcinoma (4 of 7) or ... Full text Link to item Cite

Incorporating single-side sparing in models for predicting parotid dose sparing in head and neck IMRT.

Journal Article Med Phys · February 2014 PURPOSE: Sparing of single-side parotid gland is a common practice in head-and-neck (HN) intensity modulated radiation therapy (IMRT) planning. It is a special case of dose sparing tradeoff between different organs-at-risk. The authors describe an improved ... Full text Link to item Cite

A limited-angle intrafraction verification (LIVE) system for radiation therapy.

Journal Article Med Phys · February 2014 PURPOSE: Currently, no 3D or 4D volumetric x-ray imaging techniques are available for intrafraction verification of target position during actual treatment delivery or in-between treatment beams, which is critical for stereotactic radiosurgery (SRS) and st ... Full text Link to item Cite

Evaluating radiation-induced white matter changes in patients treated with stereotactic radiosurgery using diffusion tensor imaging: a pilot study.

Journal Article Technol Cancer Res Treat · February 2014 Stereotactic radiosurgery (SRS) has been an effective treatment method for brain tumors; however, few data are available regarding radiation-induced white matter (WM) damage by SRS. In this work, diffusion tensor imaging (DTI) was used to investigate WM ch ... Full text Link to item Cite

Dynamic electron arc radiotherapy (DEAR): a feasibility study.

Journal Article Phys Med Biol · January 20, 2014 Compared to other radiation therapy modalities, clinical electron beam therapy has remained practically unchanged for the past few decades even though electron beams with multiple energies are widely available on most linacs. In this paper, we present the ... Full text Link to item Cite

Onboard functional and molecular imaging: a design investigation for robotic multipinhole SPECT.

Journal Article Med Phys · January 2014 PURPOSE: Onboard imaging-currently performed primarily by x-ray transmission modalities-is essential in modern radiation therapy. As radiation therapy moves toward personalized medicine, molecular imaging, which views individual gene expression, may also b ... Full text Link to item Cite

Dosimetric effects of rotational offsets in stereotactic body radiation therapy (SBRT) for lung cancer.

Journal Article Med Dosim · 2014 To quantitatively evaluate dosimetric effects of rotational offsets in stereotactic body radiation therapy (SBRT) for lung cancer. Overall, 11 lung SBRT patients (8 female and 3 male; mean age: 75.0 years) with medially located tumors were included. Treatm ... Full text Link to item Cite

Dosimetric comparison of 3D conformal, IMRT, and V-MAT techniques for accelerated partial-breast irradiation (APBI).

Journal Article Med Dosim · 2014 The purpose is to dosimetrically compare the following 3 delivery techniques: 3-dimensional conformal radiation therapy (3D-CRT), intensity-modulated arc therapy (IMRT), and volumetric-modulated arc therapy (V-MAT) in the treatment of accelerated partial-b ... Full text Link to item Cite

Stereotactic ablative body radiotherapy (SABR) for effective palliation of metastases: factors affecting local control.

Journal Article J Radiosurg SBRT · 2014 We analyzed factors associated with inferior local control following stereotactic ablative body radiotherapy (SABR) for palliation of metastases. We reviewed records of patients receiving SABR for metastases at Duke University from 2006-2010. Biologically ... Link to item Cite

Image-guided radiation therapy and frameless stereotactic radiation therapy

Chapter · January 1, 2014 This chapter gives an overview of how to adapt diagnostic imaging technologies on to linear accelerators for image-guided frameless stereotactic radiation therapy (SRT) when the primary focus is on target localization and verification inside the treatment ... Full text Cite

RTOG 0631 phase 2/3 study of image guided stereotactic radiosurgery for localized (1-3) spine metastases: phase 2 results.

Journal Article Pract Radiat Oncol · 2014 Featured Publication PURPOSE: The phase 2 component of Radiation Therapy Oncology Group (RTOG) 0631 assessed the feasibility and safety of spine radiosurgery (SRS) for localized spine metastases in a cooperative group setting. METHODS AND MATERIALS: Patients with 1-3 spine met ... Full text Link to item Cite

Uncertainties of 4-dimensional computed tomography-based tumor motion measurement for lung stereotactic body radiation therapy.

Journal Article Pract Radiat Oncol · 2014 Featured Publication PURPOSE: To evaluate how well tumor motion measured prior to treatment based on 4-dimensional computer tomography (4DCT) reflects actual tumor motion during beam-on throughout the course of treatment. METHODS AND MATERIALS: Twenty-three patients who had lu ... Full text Link to item Cite

A technique for estimating 4D-CBCT using prior knowledge and limited-angle projections.

Journal Article Med Phys · December 2013 PURPOSE: To develop a technique to estimate onboard 4D-CBCT using prior information and limited-angle projections for potential 4D target verification of lung radiotherapy. METHODS: Each phase of onboard 4D-CBCT is considered as a deformation from one sele ... Full text Link to item Cite

Modeling the dosimetry of organ-at-risk in head and neck IMRT planning: an intertechnique and interinstitutional study.

Journal Article Med Phys · December 2013 PURPOSE: To build a statistical model to quantitatively correlate the anatomic features of structures and the corresponding dose-volume histogram (DVH) of head and neck (HN) Tomotherapy (Tomo) plans. To study if the model built upon one intensity modulated ... Full text Link to item Cite

A line-source method for aligning on-board and other pinhole SPECT systems.

Journal Article Med Phys · December 2013 PURPOSE: In order to achieve functional and molecular imaging as patients are in position for radiation therapy, a robotic multipinhole SPECT system is being developed. Alignment of the SPECT system-to the linear accelerator (LINAC) coordinate frame and to ... Full text Link to item Cite

Generation of virtual monochromatic CBCT from dual kV∕MV beam projections.

Journal Article Med Phys · December 2013 PURPOSE: To develop a novel on-board imaging technique which allows generation of virtual monochromatic (VM) cone-beam CT (CBCT) with a selected energy from combined kilovoltage (kV)∕megavoltage (MV) beam projections. METHODS: With the current orthogonal k ... Full text Link to item Cite

Strategies for automatic online treatment plan reoptimization using clinical treatment planning system: a planning parameters study.

Journal Article Med Phys · November 2013 PURPOSE: Adaptive radiation therapy for prostate cancer using online reoptimization provides an improved control of interfractional anatomy variations. However, the clinical implementation of online reoptimization is currently limited by the low efficiency ... Full text Link to item Cite

Evaluation of the effect of respiratory and anatomical variables on a Fourier technique for markerless, self-sorted 4D-CBCT.

Journal Article Phys Med Biol · October 21, 2013 A novel technique based on Fourier transform theory has been developed that directly extracts respiratory information from projections without the use of external surrogates. While the feasibility has been demonstrated with three patients, a more extensive ... Full text Link to item Cite

A novel technique for VMAT QA with EPID in cine mode on a Varian TrueBeam linac.

Journal Article Phys Med Biol · October 7, 2013 Volumetric modulated arc therapy (VMAT) is a relatively new treatment modality for dynamic photon radiation therapy. Pre-treatment quality assurance (QA) is necessary and many efforts have been made to apply electronic portal imaging device (EPID)-based IM ... Full text Link to item Cite

Feasibility of Using a Fourier Markerless Technique for Clinical 4D-CBCT Reconstruction

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Incorporating Trade-Off in Knowledge Modeling of Parotid Dose Sparing in Head and Neck IMRT

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Quality Evaluation of an Automatic VMAT Planning Method for Head-and-Neck Cancer Cases

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Effects of PET Reconstruction Parameters on Region-of-Interest Contouring by SUV Threshold

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Modeling Organs at Risk Dose Sparing in Head and Neck Tomotherapy and IMRT Plans: A Comparison Study

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Normal Tissue Toxicity Criteria in Radiation Therapy

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Quantitative Comparison of Knowledge-Guided IMRT Planning to Expert Planning for Prostate Cancer

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Intertechnique and Interinstitutional Modeling of the Dosimetry of Organs-at-Risk in Head and Neck IMRT Plans

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Single institution's dosimetry and IGRT analysis of prostate SBRT.

Journal Article Radiat Oncol · September 13, 2013 BACKGROUND AND PURPOSE: To report single institution's IGRT and dosimetry analysis on the 37 Gy/5 fraction prostate SBRT clinical trial. MATERIALS/METHODS: The IRB (Duke University Medical Center) approved clinical trial has treated 28 patients with stage ... Full text Link to item Cite

A knowledge-based approach to improving and homogenizing intensity modulated radiation therapy planning quality among treatment centers: an example application to prostate cancer planning.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2013 Featured Publication PURPOSE: Intensity modulated radiation therapy (IMRT) treatment planning can have wide variation among different treatment centers. We propose a system to leverage the IMRT planning experience of larger institutions to automatically create high-quality pla ... Full text Link to item Cite

Adaptive stereotactic body radiation therapy planning for lung cancer.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2013 Featured Publication PURPOSE: To investigate the dosimetric effects of adaptive planning on lung stereotactic body radiation therapy (SBRT). METHODS AND MATERIALS: Forty of 66 consecutive lung SBRT patients were selected for a retrospective adaptive planning study. CBCT images ... Full text Link to item Cite

In reply to Kumar et al.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2013 Full text Link to item Cite

Radiotherapy and radiosurgery for tumors of the central nervous system.

Journal Article Surg Oncol Clin N Am · July 2013 Featured Publication In this article, the application of radiotherapy, alone and in combination with surgery and chemotherapy, in the treatment of metastases to the brain (the most common malignant brain lesion), primary malignant gliomas (the most common malignant primary bra ... Full text Link to item Cite

Respiration-phase-matched digital tomosynthesis imaging for moving target verification: a feasibility study.

Journal Article Med Phys · July 2013 PURPOSE: To develop a respiration-phase-matched digital tomosynthesis (DTS) technique to monitor moving targets, and to evaluate its accuracy for various imaging parameters and anatomical characteristics. METHODS: Previously developed 3D-DTS techniques, re ... Full text Link to item Cite

SU-E-T-143: Dosimetric Characteristics of TrueBeam STx System with High Definition Multi-Leaf Collimator: Commissioning of Stereotactic Radiosurgery.

Journal Article Med Phys · June 2013 IntroductionDosimetric characteristics of one TrueBeam STx treatment unit with a 120-leaf high definition multileaf collimator (HD120MLC) are systematically measured for commissioning of stereotactic radiosurgery (SRS). Due to limited data available, it is ... Full text Link to item Cite

SU-E-T-196: Pretreatment Patient Clinical Objective IMRT Quality Assurance Using a 3D Diode Array.

Conference Med Phys · June 2013 PURPOSE: To evaluate the accuracy and sensitivity of a patient clinical objective IMRT QA tool using a 3D diode array. METHODS: A 3D QA device (Delta4, Scandidos Inc.) with 2 orthogonal diode array planes was used for IMRT QA. The diode spacing is 5mm in c ... Full text Link to item Cite

WE-G-108-08: A Novel Technique for VMAT QA with EPID in Cine Mode On Varian TrueBeam.

Conference Med Phys · June 2013 PURPOSE: Volumetric modulated arc therapy (VMAT) is a relatively new treatment modality for dynamic photon radiation therapy. Pre-treatment quality assurance (QA) is necessary and many efforts have been taken to apply electronic portal imaging device (EPID ... Full text Link to item Cite

TU-G-134-01: 4D-MRI Using Body Area as Internal Respiratory Surrogate: Initial Patient Results.

Journal Article Med Phys · June 2013 PURPOSE: We have previously developed a novel 4D-MRI technique using body area (BA) as internal respiratory surrogate. This study is to demonstrate our initial patient results via validating the accuracy of tumor motion measurements and the improvement of ... Full text Link to item Cite

TH-C-141-07: T2-Weighted 4D-MRI with Combined Phase and Amplitude Sorting.

Journal Article Med Phys · June 2013 PURPOSE: T2-weighted MR provides excellent delineation of malignant liver lesions due to its superior tumor-to-tissue contrast. This study aims to develop a novel T2-weighted retrospective 4D-MRI technique for imaging organ/tumor respiratory motion with im ... Full text Link to item Cite

WE-C-116-07: Tumor Enhancement Using Deformable Image Registration for Four-Dimensional Magnetic Resonance Imaging (4D-MRI): A Feasibility Study.

Journal Article Med Phys · June 2013 PURPOSE: We have previously developed a 4D-MRI technique using the fast imaging sequence employing steady-state acquisition (FIESTA) sequence, which has suboptimal tumor-to-tissue contrast-to-noise ratio (CNR) due to its T2*/T1 weighting. This study invest ... Full text Link to item Cite

WE-G-134-04: Four-Dimensional Dual Cone-Beam CT (4D-DCBCT): Preliminary Experimental Results.

Journal Article Med Phys · June 2013 PURPOSE: One of the major challenges for clinical implementation of 4D-CBCT is long scan time. This study aims to develop a 4D-DCBCT technique to improve the efficiency of 4D imaging (for motion management in radiation therapy). METHODS: A bench-top DCBCT ... Full text Link to item Cite

WE-A-500-01: Quality Control of Lung SBRT: Minimizing Uncertainties From Simulation to Treatment.

Journal Article Med Phys · June 2013 Stringent quality control is critical to the success of lung SBRT. However, uncertainties exist in each step of the lung SBRT procedure. Characterization of organ motion using 4DCT may not present true tumor motion excursion due to its low temporal resolut ... Full text Link to item Cite

MO-F-WAB-11: Investigation of CBCT-Based Patient Positioning Accuracy in Lung SBRT: Correlation with Breathing Irregularity.

Conference Med Phys · June 2013 PURPOSE: To evaluate breathing irregularity induced error in CBCT-based patient positioning in lung SBRT and correlate the error with a measure of breathing variability. METHODS: The 4D extended cardiac-torso (XCAT) digital phantom was used to generate 10- ... Full text Link to item Cite

SU-E-T-560: A Method to Determine Optimal Dynamic MLC Parameters for Varian Truebeam with Millennium MLC and HDMLC.

Conference Med Phys · June 2013 PURPOSE: Correct MLC modeling is essential to the accurate IMRT delivery. Most TPSs use simplified models with parameters of leaf transmission (LT) and dynamic leaf gap (DLG). The common way to determine them is through extrapolation from measurements. In ... Full text Link to item Cite

WE-A-134-04: Comprehensive Evaluation of a Respiration-Phase-Matched Digital Tomosynthesis (DTS) Imaging Technique for Monitoring Moving Targets.

Conference Med Phys · June 2013 PURPOSE: To develop a respiration-phase-matched DTS technique to monitor moving targets, and to evaluate its accuracy for various imaging parameters and anatomical characteristics Methods: Conventional methods, registering on-board DTS(OB-DTS, reconstructe ... Full text Link to item Cite

TU-G-141-03: An On-Board 4D-CBCT Reconstruction Technique Using Limited-Angle Projections Based On Motion Modeling and Free-Form Deformation (MM-FD).

Conference Med Phys · June 2013 PURPOSE: To develop an on-board 4D-CBCT(OB-4D-CBCT) reconstruction technique using prior information and limited-angle projections for 4D inter/intra-fractional target verificationMethods: The OB-4D-CBCT at each phase is considered as a deformation of plan ... Full text Link to item Cite

SU-E-T-602: Dynamic Electron Arc Radiotherapy (DEAR): A Planning Study.

Conference Med Phys · June 2013 PURPOSE: Electron beam therapy is under-utilized in radiation treatment of cancer and has remained practically unchanged for decades. We propose a new technique, Dynamic Electron Arc Radiotherapy (DEAR) with synchronized couch motion. In DEAR, gantry rotat ... Full text Link to item Cite

TH-C-137-11: Dose-Guided Automatic IMRT Planning: A Feasibility Study.

Journal Article Med Phys · June 2013 PURPOSE: To develop and evaluate an automatic planning technique for prostate cancer utilizing prior expert plan's dose as guidance. METHODS: A plan atlas was created using 10 expert prostate IMRT plans covering a variety of typical anatomical configuratio ... Full text Link to item Cite

SU-D-500-06: On-Board Robotic Multi-Pinhole SPECT System for Prone Breast Imaging.

Journal Article Med Phys · June 2013 PURPOSE: To investigate a novel Single Photon Emission Computed Tomography (SPECT) system for on-board molecular and functional imaging in partial breast radiation therapy of prone patients. METHODS: Computer-simulation studies were performed for on-board ... Full text Link to item Cite

Spiral computed tomography phase-space source model in the BEAMnrc/EGSnrc Monte Carlo system: implementation and validation.

Journal Article Phys Med Biol · April 21, 2013 Featured Publication Currently, the BEAMnrc/EGSnrc Monte Carlo (MC) system does not provide a spiral CT source model for the simulation of spiral CT scanning. We developed and validated a spiral CT phase-space source model in the BEAMnrc/EGSnrc system. The spiral phase-space s ... Full text Link to item Cite

Quality requirements for stereotactic body radiation therapy (SBRT) in multi-institutional clinical trials

Journal Article IFMBE Proceedings · April 16, 2013 Featured Publication Clinical evidence have shown SBRT to be a tolerable, efficacious, and promising non-invasive therapy. Randomized prospective studies comparing surgery vs. SBRT in early-stage lung cancer are proposed to further investigate the relative survival, quality of ... Full text Cite

Quantification and minimization of uncertainties of internal target volume for stereotactic body radiation therapy of lung cancer.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2013 Featured Publication PURPOSE: To quantify uncertainties in delineating an internal target volume (ITV) and to understand how these uncertainties may be individually minimized for stereotactic body radiation therapy (SBRT) of early stage non-small cell lung cancer (NSCLC). METH ... Full text Link to item Cite

A dual cone-beam CT system for image guided radiotherapy: initial performance characterization.

Journal Article Med Phys · February 2013 Featured Publication PURPOSE: The purpose of this study is to evaluate the performance of a recently developed benchtop dual cone-beam computed tomography (CBCT) system with two orthogonally placed tube∕detector sets. METHODS: The benchtop dual CBCT system consists of two orth ... Full text Link to item Cite

Investigation of sliced body volume (SBV) as respiratory surrogate.

Journal Article J Appl Clin Med Phys · January 7, 2013 Featured Publication The purpose of this study was to evaluate the sliced body volume (SBV) as a respiratory surrogate by comparing with the real-time position management (RPM) in phantom and patient cases. Using the SBV surrogate, breathing signals were extracted from unsorte ... Full text Open Access Link to item Cite

TH‐A‐WAB‐04: Respiratory Sorted Imaging Using Region‐Of‐Interest Robotic Multi‐Pinhole SPECT System

Conference Medical Physics · January 1, 2013 Purpose: Single Photon Emission Computed Tomography (SPECT) may provide important information on tumors in the thorax and abdomen. Respiratory sorted imaging using conventional full cross‐section methods is generally degraded by noise. The purpose is to in ... Full text Cite

WE‐G‐500‐09: Robotic Multi‐Pinhole Scenarios for SPECT Molecular and Functional Imaging Onboard and in Other Applications

Conference Medical Physics · January 1, 2013 Purpose: Single Photon Emission Computed Tomography (SPECT) is one of the two predominant modes of nuclear emission tomography, the other being Positron Emission Tomography (PET). An important recent advance has been region‐of‐interest (ROI) SPECT for card ... Full text Cite

SU‐E‐J‐200: Impact of FDG‐PET/CT Reconstruction Parameters On PET Variability and Treatment Response Assessment

Conference Medical Physics · January 1, 2013 Purpose: To examine the effect of PET image reconstruction parameters on baseline and early‐treatment FDG‐PET/CT quantitative imaging. Early‐treatment changes in tumor metabolism in primary tumor and nodes can potentially determine if the patient is respon ... Full text Cite

SU‐E‐T‐474: Adaptive Stereotactic Body Radiation Therapy (SBRT) Planning for Lung Cancer: Can We Predict Who Will Benefit?

Conference Medical Physics · January 1, 2013 Purpose: We have previously shown that adaptive lung SBRT planning can mitigate dose to adjacent organs at risk (OARs). The aim of this study is to investigate factors that affect dosimetric effectiveness of adaptive lung SBRT, so that we may predict which ... Full text Cite

TU‐C‐141‐08: Evaluate Deformable Image Registration for the Lungs Using Hyperpolarized Gas Tagging MRI

Conference Medical Physics · January 1, 2013 Purpose: To evaluate deformable image registration for the lungs using hyperpolarized gas MR tagging technique.Method and Materials: A 3D MR grid‐tagging technique using hyperpolarized helium‐3 (HP‐He3) as gaseous contrast was developed for direct measurem ... Full text Cite

SU‐E‐J‐150: Investigation of Feasibility of Concurrent Orthogonal KV and MV X‐Ray Imaging for Tagrget Tracking During Dose Delivery for Stereotactic Body Radiotherapy (SBRT): A Pilot Phantom Study

Conference Medical Physics · January 1, 2013 Purpose: To investigate feasibility of motion tracking using concurrent orthogonal kV and MV x‐ray images acquired during dose delivery for stereotactic body radiotherapy (SBRT).Method and Materials: The study was performed on a Varian TrueBeam treatment u ... Full text Cite

SU‐E‐CAMPUS‐J‐04: Evaluating Radiation‐Induced Changes with Diffusion Weighted MRI and Dynamic Contrast Enhanced MRI in Patients with Early Stage Breast Cancer Treated with Stereotactic Body Radiotherapy: Initial Results

Conference Medical Physics · January 1, 2013 Purpose: Pre‐operative stereotactic body radiosurgery (SBRT) was delivered in a single fraction to treat patients with early stage breast cancer; however, few data are available regarding radiation‐induced changes by SBRT. In this work, diffusion weighted ... Full text Cite

SU‐E‐T‐707: Evaluation of the Quality of Organs‐At‐Risk Dose Sparing in Anorectal and Prostate IMRT Plans

Conference Medical Physics · January 1, 2013 Purpose: To evaluate the quality of organs‐at‐risk (OARs) dose sparing in IMRT plans for anorectal and prostate cancer cases utilizing organ‐based knowledge models to predict OAR DVHs.MethodsThe quality of OAR dose sparing in IMRT plans are evaluated by or ... Full text Cite

TH‐C‐137‐08: Dosimetric Quality of An Automatic IMRT Planning Method for Head and Neck Cancer Cases

Conference Medical Physics · January 1, 2013 Purpose: To evaluate the dosimetric quality of an automatic IMRT planning method for Head and Neck (HN) cancer cases. Methods: Eighteen HN cancer patients are planned with nine equally spaced IMRT beams. The OAR dose sparing objectives for each plan (prima ... Full text Cite

SU‐E‐CAMPUS‐T‐05: Quality Evaluation of An Automatic VMAT Planning Method for Head and Neck Cancer Cases

Conference Medical Physics · January 1, 2013 Purpose: To evaluate the dosimetric quality of an automatic volumetric‐modulated arc therapy (VMAT) planning method for Head and Neck (HN) cancer cases. Methods: Eighteen HN cancer cases are planned automatically by 2‐arc VMAT. An OAR DVH prediction model ... Full text Cite

TU‐E‐108‐02: Dynamic Electron Arc Radiotherapy (DEAR): A Feasibility Study

Conference Medical Physics · January 1, 2013 Purpose: Electron beam therapy is under‐utilized in radiation treatment of cancer and has remained practically unchanged for decades. We propose a new technique, Dynamic Electron Arc Radiotherapy (DEAR) with synchronized couch motion. DEAR utilizes modulat ... Full text Cite

SU‐E‐J‐91: Developing Platform for Online Registration Using Digital Tomosynthesis

Conference Medical Physics · January 1, 2013 Purpose: To meet the needs of fast registration of on‐board digital tomosynthesis (DTS), a platform was developed in assisting the task of intensive DTS reconstruction and analysis. Methods: this platform consists of four parts: pre‐processing, reconstruct ... Full text Cite

Implementation of remote 3-dimensional image guided radiation therapy quality assurance for radiation therapy oncology group clinical trials.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2013 Featured Publication PURPOSE: To report the process and initial experience of remote credentialing of three-dimensional (3D) image guided radiation therapy (IGRT) as part of the quality assurance (QA) of submitted data for Radiation Therapy Oncology Group (RTOG) clinical trial ... Full text Link to item Cite

Investigation of sliced body volume (SBV) as respiratory surrogate

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2013 Featured Publication The purpose of this study was to evaluate the sliced body volume (SBV) as a respiratory surrogate by comparing with the real-time position management (RPM) in phantom and patient cases. Using the SBV surrogate, breathing signals were extracted from unsorte ... Full text Cite

Implementing and integrating a clinically driven electronic medical record for radiation oncology in a large medical enterprise.

Journal Article Front Oncol · 2013 PURPOSE/OBJECTIVE: While our department is heavily invested in computer-based treatment planning, we historically relied on paper-based charts for management of Radiation Oncology patients. In early 2009, we initiated the process of conversion to an electr ... Full text Link to item Cite

The effect of motion on IMRT - looking at interplay with 3D measurements.

Conference J Phys Conf Ser · 2013 Six base of skull IMRT treatment plans were delivered to 3D dosimeters within the RPC Head and Neck Phantom for QA verification. Isotropic 2mm 3D data was obtained using the DLOS-PRESAGE system and compared to an Eclipse (Varian) treatment plan. Normalized ... Full text Link to item Cite

Interleaved acquisition for cross scatter avoidance in dual cone-beam CT.

Journal Article Med Phys · December 2012 Featured Publication PURPOSE: Cone-beam x-ray imaging with flat panel detectors is used for target localization in image guided radiation therapy. This imaging includes cone-beam computed tomography (CBCT) and planar imaging. Use of two orthogonal x-ray systems could reduce im ... Full text Link to item Cite

Generation of Virtual Monochromatic (VM) CBCT from Dual kV/MV Beam Projections

Conference International Journal of Radiation Oncology*Biology*Physics · November 2012 Full text Cite

Commissioning and dosimetric characteristics of TrueBeam system: composite data of three TrueBeam machines.

Journal Article Med Phys · November 2012 Featured Publication PURPOSE: A TrueBeam linear accelerator (TB-LINAC) is designed to deliver traditionally flattened and flattening-filter-free (FFF) beams. Although it has been widely adopted in many clinics for patient treatment, limited information is available related to ... Full text Link to item Cite

Quantitative analysis of the factors which affect the interpatient organ-at-risk dose sparing variation in IMRT plans.

Journal Article Med Phys · November 2012 Featured Publication PURPOSE: The authors present an evidence-based approach to quantify the effects of an array of patient anatomical features of the planning target volumes (PTVs) and organs-at-risk (OARs) and their spatial relationships on the interpatient OAR dose sparing ... Full text Link to item Cite

Stereotactic body radiotherapy treatment of extracranial metastases.

Journal Article Nat Rev Clin Oncol · November 2012 Featured Publication Radiotherapy is an integral treatment for patients with metastatic cancer, although it is usually reserved for palliation of pain, dyspnoea, oedema, bleeding and neurological symptoms. However, the administration of high-precision radiotherapy, termed ster ... Full text Link to item Cite

Reproducibility of tumor motion probability distribution function in stereotactic body radiation therapy of lung cancer.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2012 Featured Publication PURPOSE: To evaluate the reproducibility of tumor motion probability distribution function (PDF) in stereotactic body radiation therapy (SBRT) of lung cancer using cine megavoltage (MV) images. METHODS AND MATERIALS: Cine MV images of 20 patients acquired ... Full text Link to item Cite

Dosimetric Evaluation of Flattening Filter-free (FFF) Photon Beams for Lung SBRT

Conference International Journal of Radiation Oncology*Biology*Physics · November 2012 Full text Cite

Impact of Patient Anatomy Variations on a Fourier Technique for Markerless 4D-CBCT

Conference International Journal of Radiation Oncology*Biology*Physics · November 2012 Full text Cite

Prostate SBRT in 5 Fractions: Initial Report on Dosimetric Results and IGRT Experiences

Conference International Journal of Radiation Oncology*Biology*Physics · November 2012 Full text Cite

Can Standard Radiation Therapy Quality Assurance (QA) Detect Potential Delivery Errors?

Conference International Journal of Radiation Oncology*Biology*Physics · November 2012 Full text Cite

Evaluation of IMRT and VMAT for Head-and-Neck Cancer With Flattening Filter-free (FFF) Beams

Conference International Journal of Radiation Oncology*Biology*Physics · November 2012 Full text Cite

Partial Breast Extracranial Radiosurgery: A Dosimetric Evaluation of Treatment Delivery Accuracy

Conference International Journal of Radiation Oncology*Biology*Physics · November 2012 Full text Cite

Implementation of dual-energy technique for virtual monochromatic and linearly mixed CBCTs.

Journal Article Med Phys · October 2012 Featured Publication PURPOSE: To implement dual-energy imaging technique for virtual monochromatic (VM) and linearly mixed (LM) cone beam CTs (CBCTs) and to demonstrate their potential applications in metal artifact reduction and contrast enhancement in image-guided radiation ... Full text Link to item Cite

Feasibility study of a synchronized-moving-grid (SMOG) system to improve image quality in cone-beam computed tomography (CBCT).

Journal Article Med Phys · August 2012 Featured Publication PURPOSE: To evaluate the feasibility of a synchronized moving grid (SMOG) system to remove scatter artifacts, improve the contrast-to-noise ratio (CNR), and reduce image lag artifacts in cone-beam CT (CBCT). METHODS: The SMOG system proposed here uses a ra ... Full text Link to item Cite

Imaging system QA of a medical accelerator, Novalis Tx, for IGRT per TG 142: our 1 year experience.

Journal Article J Appl Clin Med Phys · July 5, 2012 Featured Publication American Association of Physicists in Medicine (AAPM) task group (TG) 142 has recently published a report to update recommendations of the AAPM TG 40 report and add new recommendations concerning medical accelerators in the era of image-guided radiation th ... Full text Open Access Link to item Cite

SU-E-J-209: A Simple Method to Minimize Uncertainty in ITV Delineation: Phantom Verification.

Journal Article Med Phys · June 2012 PURPOSE: Irregular breathing causes variation in delineation of internal target volume (ITV), which is typically generated in the maximum intensity projection (MIP) images [1]. Previous studies have shown that MIP-based ITV can underestimate true tumor ran ... Full text Link to item Cite

SU-E-J-145: Implementing 4D XCAT Phantom for 4D Radiotherapy Research.

Journal Article Med Phys · June 2012 PURPOSE: To characterize and implement the 4D Integrated Extended Cardiac Torso (XCAT) digital phantom for 4D radiotherapy (RT) application. METHODS: A computer program was developed to facilitate the characterization and implementation of the 4D XCAT phan ... Full text Link to item Cite

TU-E-BRB-04: Adaptive Stereotactic-Body Radiation Therapy (SBRT) Planning for Lung Cancer.

Journal Article Med Phys · June 2012 PURPOSE: Tumor shrinkage during lung SBRT has been reported. Adaptive SBRT planning can potentially escalate dose to the target and mitigate dose to surrounding tissues. In this study, we investigated dosimetric effects of adaptive lung SBRT planning using ... Full text Link to item Cite

MO-A-213AB-04: Verification of 4D Dose Delivery Using 4D Digital Human Phantom.

Journal Article Med Phys · June 2012 PURPOSE: At present, techniques of 4D dose verification in radiation therapy for lung cancers associated with respiratory motion are very limited, due to either lack of patient anatomy or breathing information. The aim of this study is to develop a 4D dose ... Full text Link to item Cite

SU-D-218-02: 4D-MRI Based on Body Area (BA) Surrogate and Sagittal Image Acquisition.

Journal Article Med Phys · June 2012 PURPOSE: 4D-MRI based on body area (BA) surrogate using axial image acquisition has been demonstrated. Since respiratory motion mostly occurs in the superior-inferior (SI) direction, it is expected that sagittal acquisition may provide more robust and accu ... Full text Link to item Cite

SU-E-J-32: Evaluation of the Dosimetric Accuracy of Stereotactic Radiosurgery with Cone-Beam Computed Tomography Localization.

Journal Article Med Phys · June 2012 PURPOSE: To evaluate the dosimetric accuracy of stereotactic radiosurgery (SRS) with cone-beam computed tomography (CBCT) guided patient localization. METHODS: A Novalis TX linear accelerator with high definition multileaf collimator (HDMLC) was used for S ... Full text Link to item Cite

SU-E-T-104: Commissioning and Dosimetric Characteristics of TrueBeam System: Composite Data of Three TrueBeam Machines.

Journal Article Med Phys · June 2012 INTRODUCTION: A TrueBeam linear accelerator (TB-LINAC) is designed to deliver standard flattened and flattening-filter-free (FFF) beams. In our institute, three TB-LINAC units are installed. In this work, composite data of the three units and multi-unit co ... Full text Link to item Cite

MO-D-BRB-09: Treatment Delivery QA for Online Adaptive Radiation Therapy Based on Dynamic Machine Information (DMI): A Feasibility Study.

Journal Article Med Phys · June 2012 PURPOSE: To implement a quality assurance (QA) system for the treatment delivery of online adaptive radiation therapy utilizing Dynamic Machine Information (DMI). MATERIALS AND METHODS: DMI provides the expected/actual MLC leaf-positions, delivered MU, and ... Full text Link to item Cite

SU-E-T-559: Evaluation of Flatening Filter Free (FFF) Beams in Radiotherapy of Head and Neck Cancer.

Journal Article Med Phys · June 2012 PURPOSE: To investigate th applicability of the flattening filter free (FFF) to fractionated radiotherapy of head and neck cancer. METHODS: Twelve patients previously treated with IMRT were selected. A SIB protocol was chosen so that 66/54 Gy were prescrib ... Full text Link to item Cite

Stereotactic radiotherapy for malignancies involving the trigeminal and facial nerves.

Journal Article Technol Cancer Res Treat · June 2012 Featured Publication Involvement of a cranial nerve caries a poor prognosis for many malignancies. Recurrent or residual disease in the trigeminal or facial nerve after primary therapy poses a challenge due to the location of the nerve in the skull base, the proximity to the b ... Full text Link to item Cite

SU-E-T-406: Online Image-Guidance for Prostate SBRT: Dosimetric Benefits and Margin Analysis.

Conference Med Phys · June 2012 PURPOSE: To evaluate the dosimetric benefits of online image guidance during prostate stereotactic body radiotherapy (SBRT) and the potential on margin reduction. METHODS: 28 prostate SBRT patients were retrospectively studied, each treated with 37Gy in 5 ... Full text Link to item Cite

SU-E-T-626: Individualized Trade-Off of Dose Coverage and Sparing in IMRT Planning.

Conference Med Phys · June 2012 PURPOSE: We present an evidence-based approach to quantifying the dose sparing trade-offs between different Organs-at-risk (OARs) and the trade-off between OAR dose sparing and target dose coverage in IMRT plans. METHODS: The interaction between dose spari ... Full text Link to item Cite

MO-D-BRB-10: Modeling Inter-Patient Variation of Organ-At-Risk Sparing in IMRT Plans: An Evidence-Based Plan Quality Evaluation.

Conference Med Phys · June 2012 PURPOSE: To develop a predictive model to assess the quality of critical organ dose sparing in IMRT plans by providing patient specific dose sparing references, based on an array of patient anatomical features and prior planning experience. METHODS: Contri ... Full text Link to item Cite

Target localization using scanner-acquired SPECT data.

Journal Article J Appl Clin Med Phys · May 10, 2012 Featured Publication Target localization using single photon emission computed tomography (SPECT) and planar imaging is being investigated for guiding radiation therapy delivery. Previous studies on SPECT-based localization have used computer-simulated or hybrid images with si ... Full text Open Access Link to item Cite

Dosimetric comparison of treatment plans based on free breathing, maximum, and average intensity projection CTs for lung cancer SBRT.

Journal Article Med Phys · May 2012 Featured Publication PURPOSE: To determine whether there is a CT dataset may be more favorable for planning and dose calculation by comparing dosimetric characteristics between treatment plans calculated using free breathing (FB), maximum and average intensity projection (MIP ... Full text Link to item Cite

Comparison of 3D conformal breast radiation treatment plans using the anisotropic analytical algorithm and pencil beam convolution algorithm.

Journal Article Radiother Oncol · May 2012 Featured Publication PURPOSE: To investigate (1) dosimetric differences between plans calculated using the anisotropic analytical algorithm (AAA) and pencil beam convolution (PBC) algorithm, (2) the plan quality achieved using AAA compared to PBC based on dosimetric parameters ... Full text Link to item Cite

Volumetric-modulated arc therapy: effective and efficient end-to-end patient-specific quality assurance.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2012 Featured Publication PURPOSE: To explore an effective and efficient end-to-end patient-specific quality-assurance (QA) protocol for volumetric modulated arc radiotherapy (VMAT) and to evaluate the suitability of a stationary radiotherapy QA device (two-dimensional [2D] ion cha ... Full text Link to item Cite

Development and clinical evaluation of a three-dimensional cone-beam computed tomography estimation method using a deformation field map.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2012 Featured Publication PURPOSE: To develop a three-dimensional (3D) cone-beam computed tomography (CBCT) estimation method using a deformation field map, and to evaluate and optimize the efficiency and accuracy of the method for use in the clinical setting. METHODS AND MATERIALS ... Full text Link to item Cite

Accelerating phase contrast MR angiography by simplified skipped phase encoding and edge deghosting with array coil enhancement.

Journal Article Med Phys · March 2012 Featured Publication PURPOSE: The aim of this work is to investigate the feasibility of accelerating phase contrast magnetic resonance angiography (PC-MRA) by the fast imaging method of simplified skipped phase encoding and edge deghosting with array coil enhancement (S-SPEED- ... Full text Link to item Cite

A novel technique for markerless, self-sorted 4D-CBCT: feasibility study.

Journal Article Med Phys · March 2012 Featured Publication PURPOSE: Four-dimensional CBCT (4D-CBCT) imaging in the treatment room can provide verification of moving targets, facilitating the potential for margin reduction and consequent dose escalation. Reconstruction of 4D-CBCT images requires correlation of resp ... Full text Link to item Cite

Lipiodol: a potential direct surrogate for cone-beam computed tomography image guidance in radiotherapy of liver tumor.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2012 Featured Publication PURPOSE: To investigate the feasibility of using lipiodol as a direct surrogate for target localization using cone-beam CT (CBCT) image guidance in radiotherapy (RT) of patients with unresectable liver tumors after transarterial chemoembolization. METHODS ... Full text Link to item Cite

DOSE DEPENDENCE OF RADIATION-INDUCED ERECTILE DYSFUNCTION IN AN ANIMAL MODEL

Journal Article JOURNAL OF SEXUAL MEDICINE · February 1, 2012 Link to item Cite

TU‐A‐213CD‐04: A Novel Technique for Estimating and Correcting Cross‐Scatter in Dual‐Source CBCT

Conference Medical Physics · January 1, 2012 Purpose: Dual‐source CBCT may provide several advantages over current on‐board 3D localization techniques; however, dual‐source CBCT suffers greatly from cross‐scatter. A novel technique was developed that includes sampling the cross‐scatter only projectio ... Full text Cite

TH‐E‐BRA‐01: A Line‐Source Method for Aligning Onboard‐Robotic‐Pinhole and Other SPECT‐Pinhole Systems

Conference Medical Physics · January 1, 2012 Purpose: To achieve on‐board molecular imaging in the radiation therapy room, we are developing a robotic multi‐pinhole SPECT system. Alignment of the SPECT system to LINAC/CBCT coordinates is essential for target localization and image reconstruction. Pin ... Full text Cite

TU‐A‐BRA‐01: A Robotic Multi‐Pinhole SPECT System for Onboard and Other Region‐Of‐Interest Imaging

Conference Medical Physics · January 1, 2012 Purpose: Radiation therapy beam guidance and modulation at treatment time could be substantially supported by onboard molecular and functional imaging capability. Currently there is very little range of technology available for this. Herein we propose and ... Full text Cite

WE‐C‐213CD‐01: Decision Support for Radiation Therapy

Conference Medical Physics · January 1, 2012 Informatics in radiation therapy is less understood. Decision support for, or knowledge‐guided, radiation therapy, is a major component of informatics, where the data is mined, modeled and turned into computable knowledge. It is critically important for ra ... Full text Cite

TH‐C‐BRB‐01: Credentialing Results from a Spine Anthropomorphic Phantom

Conference Medical Physics · January 1, 2012 Purpose: To use an anthropomorphic spine phantom for dosimetric credentialing purposes in National Cancer Institute sponsored clinical trials. Methods: An anthropomorphic spine phantom that consists of lungs, a heart, an esophagus, a spinal cord, vertebrae ... Full text Cite

On-Board Digital Tomosynthesis: An Emerging New Technology for Image-Guided Radiation Therapy

Chapter · January 1, 2012 External-beam radiation therapy is a common treatment modality for cancers. e treatment course typically consists of 30-40 daily fractions of 180-200 cGy over several weeks. On-board imaging (OBI) guidance is oen designed to track shis in patient positioni ... Full text Cite

Imaging system QA of a medical accelerator, Novalis Tx, for IGRT per TG 142: Our 1 year experience

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2012 Featured Publication American Association of Physicists in Medicine (AAPM) task group (TG) 142 has recently published a report to update recommendations of the AAPM TG 40 report and add new recommendations concerning medical accelerators in the era of image-guided radiation th ... Full text Cite

Target localization using scanner-acquired SPECT data

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2012 Featured Publication Target localization using single photon emission computed tomography (SPECT) and planar imaging is being investigated for guiding radiation therapy delivery. Previous studies on SPECT-based localization have used computer-simulated or hybrid images with si ... Full text Cite

Development of a 4D dosimetry simulation system in radiotherapy

Journal Article International Journal of Biomedical Engineering and Technology · January 1, 2012 Featured Publication 4D CT image sets are used to encode patient-organ motion and to calculate the dose delivered during each respiratory phase. The dose-per-phase is summarised to the total dose via deformable registration. The system incorporates the actual beam parameters a ... Full text Cite

Establishing a framework to implement 4D XCAT phantom for 4D radiotherapy research.

Journal Article J Cancer Res Ther · 2012 Featured Publication AIMS: To establish a framework to implement the 4D integrated extended cardiac torso (XCAT) digital phantom for 4D radiotherapy (RT) research. MATERIALS AND METHODS: A computer program was developed to facilitate the characterization and implementation of ... Full text Link to item Cite

Four-dimensional magnetic resonance imaging (4D-MRI) using image-based respiratory surrogate: a feasibility study.

Journal Article Med Phys · December 2011 Featured Publication PURPOSE: Four-dimensional computed tomography (4D-CT) has been widely used in radiation therapy to assess patient-specific breathing motion for determining individual safety margins. However, it has two major drawbacks: low soft-tissue contrast and an exce ... Full text Link to item Cite

RTOG 0631 Phase II/III Study of Image-Guided Stereotactic Radiosurgery for Localized (1-3) Spine Metastases: Phase II Results.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2011 PURPOSE: The phase II component of RTOG 0631 assessed the feasibility and safety of spine radiosurgery (SRS) for localized spine metastases in a cooperative group setting. MATERIALS AND METHODS: Patients with 1-3 spine metastasis with a Numerical Rating Pa ... Full text Link to item Cite

RTOG 0631 Phase II/III Study of Image-guided Stereotactic Radiosurgery for Localized Spine Metastases: Phase II Results

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Contour based respiratory motion analysis for free breathing CT.

Journal Article Comput Biol Med · October 2011 Featured Publication We propose a method to quantify superior-inferior (SI) motion of a rigid target using the 3D contour from free-breathing CT (FBCT). The technique utilizes similarity between 2D contours (Jaccard Index) and a population based density function for probabilit ... Full text Link to item Cite

Fourier Transform (FT) Techniques for Markerless 4D Cone-beam CT (4D-CBCT) Sorting: Comparison between Phase vs. Magnitude

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Correlation between External Surrogate Motion and Lung Tumor Motion: From a Statistical Point of View

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Dosimetric Evaluation and Optimization of a Novel CBCT Estimation Method for Adaptive Radiation Therapy (ART)

Conference International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

A Dual-Isocenter Technique for Image Guidance of Prone-Breast Radiation Therapy

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Radiation-induced erectile dysfunction using prostate-confined modern radiotherapy in a rat model.

Journal Article J Sex Med · August 2011 Featured Publication INTRODUCTION: The mechanisms of radiation-induced erectile dysfunction (ED) are unclear, as clinical studies are limited, and previous animal models were based on wide-field irradiation, which does not model current radiotherapy (RT) techniques. AIMS: To p ... Full text Link to item Cite

Potential underestimation of the internal target volume (ITV) from free-breathing CBCT.

Journal Article Med Phys · August 2011 Featured Publication PURPOSE: Localization prior to delivery of SBRT to free-breathing patients is performed by aligning the planning internal target volume (ITV) from 4DCT with an on-board free-breathing cone-beam CT (FB-CBCT) image. The FB-CBCT image is assumed to also gener ... Full text Link to item Cite

Evaluation of integrated respiratory gating systems on a Novalis Tx system.

Journal Article J Appl Clin Med Phys · April 4, 2011 Featured Publication The purpose of this study was to investigate the accuracy of motion tracking and radiation delivery control of integrated gating systems on a Novalis Tx system. The study was performed on a Novalis Tx system, which is equipped with Varian Real-time Positio ... Full text Open Access Link to item Cite

Crescent artifacts in cone-beam CT.

Journal Article Med Phys · April 2011 Featured Publication PURPOSE: In image-guided radiation therapy, cone-beam CT has been adopted for three-dimensional target localization in the treatment room. In many of these cone-beam CT images, dark and light crescent artifacts can be seen. This study investigates potentia ... Full text Link to item Cite

Adaptive prostate IGRT combining online re-optimization and re-positioning: a feasibility study.

Journal Article Phys Med Biol · March 7, 2011 Featured Publication In prostate radiation therapy, inter-fractional organ motion/deformation has posed significant challenges on reliable daily dose delivery. To correct for this issue, off-line re-optimization and online re-positioning have been used clinically. In this pape ... Full text Link to item Cite

A planning quality evaluation tool for prostate adaptive IMRT based on machine learning.

Journal Article Med Phys · February 2011 Featured Publication PURPOSE: To ensure plan quality for adaptive IMRT of the prostate, we developed a quantitative evaluation tool using a machine learning approach. This tool generates dose volume histograms (DVHs) of organs-at-risk (OARs) based on prior plans as a reference ... Full text Link to item Cite

Feasibility study of an intensity-modulated radiation model for the study of erectile dysfunction.

Journal Article J Sex Med · February 2011 Featured Publication INTRODUCTION: Preclinical studies of radiotherapy (RT) induced erectile dysfunction (ED) have been limited by radiation toxicity when using large fields. AIM: To develop a protocol of rat prostate irradiation using techniques mimicking the current clinical ... Full text Link to item Cite

Computed tomography dose index and dose length product for cone-beam CT: Monte Carlo simulations.

Journal Article J Appl Clin Med Phys · January 19, 2011 Featured Publication Dosimetry in kilovoltage cone beam computed tomography (CBCT) is a challenge due to the limitation of physical measurements. To address this, we used a Monte Carlo (MC) method to estimate the CT dose index (CTDI) and the dose length product (DLP) for a com ... Full text Open Access Link to item Cite

WE‐E‐301‐01: Practical Tips for VMAT Implementation

Conference Medical Physics · January 1, 2011 Volumetric modulated arc therapy (VMAT) is an arc‐based dose delivery approach that produces highly conformal dose distributions similar to those generated with static gantry intensity modulated radiation therapy. Like many existing IMRT approaches, this t ... Full text Cite

SU‐E‐T‐98: VMAT Quality Assurance: Improving the Angular Correction Factors for Ion Chamber Arrays

Conference Medical Physics · January 1, 2011 Purpose: Two‐dimensional (2D) detector arrays for QA of volumetric‐modulated‐arc‐therapy (VMAT) plans show angular dependence. An angular correction‐factor‐table (CFs) minimize this effect, but assumes: (1) the response of all ion chambers (IC) is identica ... Full text Cite

SU‐E‐J‐22: Measurement‐Based Cross‐Scatter Correction in Dual Detector Cone‐Beam CT

Conference Medical Physics · January 1, 2011 Purpose: A dual detector cone‐beam CT (CBCT) system could potentially allow for dual energy CBCT and dual‐view DTS. However, image quality in this system is severely degraded by the presence of scatter between the two imaging chains, i.e. cross‐scatter. Th ... Full text Cite

SU‐C‐214‐06: Noise Power Properties of a Dual‐Detector Cone‐Beam CT System

Conference Medical Physics · January 1, 2011 Purpose: Very little information is available for noise properties using a dual‐detector cone‐beam CT (CBCT) system. Geometric misalignment, cross‐scatter, and inhomogeneous detector response are additional concerns in a dual‐detector system. This study ch ... Full text Cite

SU‐E‐J‐180: SPECT‐Based Target Localization: Comparison between Full‐Size and Compact Detectors

Conference Medical Physics · January 1, 2011 Purpose: Single photon emission computed tomography (SPECT) is being investigated for imaging inside radiation therapy (RT) treatment rooms to target tumor biology. Because of the space occupied by RT devices and the size and weight of typical gamma camera ... Full text Cite

TU‐E‐BRC‐08: Investigation of Anatomical Surrogate for 4DCT Imaging

Conference Medical Physics · January 1, 2011 Purpose: Respiratory signal for 4DCT is typically extracted using an external respiratory positioning management device (RPM) which is often inconvenient and time consuming. The efficiency of 4DCT imaging could be substantially improved if anatomical body ... Full text Cite

SU‐E‐I‐29: A Prior Information Based Total‐Variation Digital Tomosynthesis Reconstruction Algorithm

Conference Medical Physics · January 1, 2011 Purpose: To develop a total‐variation (TV) based compressive sensing image reconstruction algorithm using a set of limited‐angle projections by applying a prior image information to enhance the image quality and anatomic information of current Four‐d ... Full text Cite

MO‐D‐214‐01: 4D‐MRI for Radiation Therapy of Moving Tumors

Conference Medical Physics · January 1, 2011 Four‐dimensional computed tomography (4D‐CT) has been widely used in radiation therapy for imaging moving tumors, especially in the thoracic regions. In other body sites such as the abdominal, 4D‐CT is limited due to its intrinsic low soft‐tissue contrast. ... Full text Cite

MO‐D‐BRB‐03: Investigation of the Reproducibility of Probability Distribution function (PDF) of Tumor Motion in Lung Stereotactic Body Radiation Therapy (SBRT)

Conference Medical Physics · January 1, 2011 Purpose: To investigate the reproducibility of probability distribution function (PDF) of lung tumor motion using cine‐MV images from lung SBRT treatments. Findings of the study will provide valuable information for probability‐based treatment planning. Me ... Full text Cite

SU‐E‐T‐123: Evaluation of Integrated Gating Systems on a Novalis Tx System Using Quantitative Motion Tracking Analyses and Efficient Time‐Delay Measurements

Conference Medical Physics · January 1, 2011 Purpose: To investigate accuracy of motion tracking and radiation delivery controlling of integrated gating systems on a Novalis Tx system. Methods: The study was performed on a Novalis Tx system, which is equipped with Varian RPM and BrainLAB ExacTrac gat ... Full text Cite

SU‐F‐BRA‐10: A Novel Technique for Markerless Self‐Sorted 4D‐CBCT

Conference Medical Physics · January 1, 2011 Purpose: Four‐dimensional (4D) imaging in the radiotherapy treatment room can provide verification of moving targets, which allows for potential reduction of margins and consequent dose escalation. 4D‐CBCT acquisition requires correlation between projectio ... Full text Cite

MO‐F‐211‐04: Fast Phase Contrast MR Angiography with Simplified Skipped Phase Encoding and Edge Deghosting with Array Coil Enhancement (S‐ SPEED‐ACE)

Conference Medical Physics · January 1, 2011 Purpose: The aim of this work is to investigate the feasibility of accelerating phase contrast MR angiography by the fast imaging method of Simplified Skipped Phase Encoding and Edge Deghosting with Array Coil Enhancement (S‐SPEED‐ACE). Methods: The parall ... Full text Cite

SU‐E‐T‐99: A Patient Specific QA Protocol for Verification of 4D Dosimetry

Conference Medical Physics · January 1, 2011 Purpose: Presently, there is no patient specific dosimetric QA for radiation treatment of moving targets. Here we present a patient specific QA protocol for verification of 4D dosimetry delivered to a moving target in SBRT of lung and liver tumors. Methods ... Full text Cite

MO‐D‐BRC‐01: Dosimetric Evaluation of a Novel Cone‐Beam CT (CBCT) Estimation Method Using Prior Information for Lung Cancer Patient Treatment

Conference Medical Physics · January 1, 2011 Purpose: To evaluate the dosimetric accuracy of a novel CBCT estimation method using prior information for use in adaptive radiotherapy (ART)‐based treatment of lung cancer patients. Methods: Patient planning CT or previous day's CBCT images are used as th ... Full text Cite

SU‐C‐110‐01: Strategies for Online Plan Re‐Optimization: Objective Settings and Starting Stage

Conference Medical Physics · January 1, 2011 Purpose: To find the most robust strategies of objective setting and starting stage for online plan re‐optimization, so it can be automatically executed within 1 min while providing high quality adaptive plans. Methods: 10 prostate cancer patients, each wi ... Full text Cite

SU‐E‐T‐860: Developing a Fast‐Monotonic Descent (FMD) Algorithm for RapidArc Radiotherapy

Conference Medical Physics · January 1, 2011 Purpose: To develop a fast‐monotonic descent (FMD) algorithm for optimization of VMAT treatment planning, and investigate the impacts of arc numbers and beam interval on the plan dose quality. Methods: Fast‐monotonic descent (FMD) algorithm, proved to be o ... Full text Cite

SU‐E‐T‐854: Key Anatomical Factors Influencing OAR Dose‐Volume Distribution in Prostate IMRT Plans

Conference Medical Physics · January 1, 2011 Purpose: To identify the key factors of patient anatomy that influence the optimal dose volume histograms (DVHs) for the organs‐at‐risk (OARs) and to explore the tradeoffs between different OAR sparing goals. Methods: 88 prostate IMRT plans were studied re ... Full text Cite

TH‐E‐BRB‐05: Modeling the Correlation Between OAR Dose Sparing and Patient's Anatomy in Head and Neck IMRT

Conference Medical Physics · January 1, 2011 Purpose: To summarize the knowledge of the dependence of organ‐at‐risk (OAR) dose‐volume distribution on patient's anatomy by machine learning techniques from a database of previous expert plans. Methods: 35 head‐and‐ neck IMRT plans were studied retrospec ... Full text Cite

Evaluation of motion measurement using cine MRI for image guided stereotactic body radiotherapy on a new phantom platform.

Journal Article J Radiosurg SBRT · 2011 The objective of this study is to investigate accuracy of motion tracking of cine magnetic resonance imaging (MRI) for image-guided stereotactic body radiotherapy. A phantom platform was developed in this work to fulfill the goal. The motion phantom consis ... Link to item Cite

Quality Assurance in Adaptive Radiation Therapy

Chapter · January 1, 2011 To ensure measurement accuracy, it is necessary to generate a comprehensive quality assurance (QA) program. “The ‘quality’ of radiation oncology can be defined as the totality of features or characteristics of the radiation oncology service that bear on it ... Full text Cite

Adaptive radiation therapy: technical components and clinical applications.

Journal Article Cancer J · 2011 Featured Publication In current standard radiation therapy process, patient anatomy is represented by the snapshot of computed tomographic images at the simulation for treatment planning. However, patient anatomy during the treatment course is not static, and the changes can b ... Full text Link to item Cite

Dosimetric comparison of 6 MV and 15 MV single arc rapidarc to helical TomoTherapy for the treatment of pancreatic cancer.

Journal Article Med Dosim · 2011 Featured Publication We conducted a planning study to compare Varian's RapidArc (RA) and helical TomoTherapy (HT) for the treatment of pancreatic cancer. Three intensity-modulated radiotherapy (IMRT) plans were generated for 8 patients with pancreatic cancer: one using HT with ... Full text Link to item Cite

Digital tomosynthesis for respiratory gated liver treatment: clinical feasibility for daily image guidance.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2011 Featured Publication PURPOSE: Breath-hold (BH) treatment minimizes internal target volumes (ITV) when treating sites prone to motion. Digital tomosynthesis (DTS) imaging has advantages over cone-beam CT (CBCT) for BH imaging: BH-DTS scan can be completed during a single breath ... Full text Link to item Cite

Evaluation of integrated respiratory gating systems on a Novalis Tx system

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2011 Featured Publication The purpose of this study was to investigate the accuracy of motion tracking and radiation delivery control of integrated gating systems on a Novalis Tx system. The study was performed on a Novalis Tx system, which is equipped with Varian Real-time Positio ... Full text Cite

Computed tomography dose index and dose length product for cone-beam CT: Monte Carlo simulations of a commercial system

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2011 Featured Publication Dosimetry in kilovoltage cone beam computed tomography (CBCT) is a challenge due to the limitation of physical measurements. To address this, we used a Monte Carlo (MC) method to estimate the CT dose index (CTDI) and the dose length product (DLP) for a com ... Full text Cite

Apparatus-dependent dosimetric differences in spine stereotactic body radiotherapy.

Journal Article Technol Cancer Res Treat · December 2010 Featured Publication The purpose of this investigation was to study apparatus-dependent dose distribution differences specific to spine stereotactic body radiotherapy (SBRT) treatment planning. This multi-institutional study was performed evaluating an image-guided robotic rad ... Full text Link to item Cite

Regional SPECT imaging using sampling principles and multiple pinholes

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2010 Featured Publication There may be many SPECT imaging applications in which a small region is primarily of interest. One such case is imaging in the radiation therapy treatment room, as the patient is on the treatment table in position for radiation therapy. This onboard imagin ... Full text Cite

Phase Window and Frame Rate Optimization for On-board 4D Imaging Dose Reduction

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Reduced Cross Scatter in Dual-source Cone-Beam CT by Asynchronous Projection Acquisition

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Potentially Underestimating the Internal Target Volume (ITV) in Free-Breathing Cone-Beam CT (CBCT)

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Maximum intensity projection (MIP) imaging using slice-stacking MRIa).

Journal Article Med Phys · November 2010 Featured Publication PURPOSE: To evaluate the feasibility of acquiring maximum intensity projection (MIP) images using a novel slice-stacking MRI (SS-MRI) technique. METHODS: The proposed technique employed a steady state acquisition sequence to image multiple axial slices. At ... Full text Link to item Cite

On-board SPECT for Target Localization: A Comprehensive Analysis of Findings from Computer Simulation and Scanner Studies

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Extracting Breathing Signal from Image Fourier Transform for Developing 4D-MRI

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Stereotactic Body Radiotherapy (SBRT) in Patients Previously Treated with External Beam Radiation Therapy

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

A Modern Animal Model of Radiation-induced Erectile Dysfunction

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Intensity Modulated Arc Therapy: Effective and Efficient End-to-end Patient Specific Quality Assurance

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Variation of Clinically Relevant Dose Indices for 3DCRT of Lung with Respect to Dose Calculation Algorithm

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Impact of volumetric modulated arc therapy technique on treatment with partial breast irradiation.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2010 Featured Publication PURPOSE: To investigate the technical feasibility of volumetric modulated arc therapy (V-MAT) in the delivery of partial breast irradiation (PBI). METHODS AND MATERIALS: V-MAT and the standard, three-dimensional conformal radiotherapy (3D-CRT), were compar ... Full text Link to item Cite

Direction-dependent localization errors in SPECT images.

Journal Article Med Phys · September 2010 Featured Publication PURPOSE: Single photon emission computed tomography (SPECT) is being investigated for imaging inside radiation therapy treatment rooms to localize biological targets. Here, computer simulations were used to analyze locational and directional dependencies i ... Full text Link to item Cite

Effects of breathing variation on gating window internal target volume in respiratory gated radiation therapya).

Journal Article Med Phys · August 2010 Featured Publication PURPOSE: To investigate the effects of breathing variation on gating window internal target volume(ITVGW) in respiratory gated radiation therapy. METHOD AND MATERIALS: Two-dimensional dynamic MRI (dMRI) of lung motion was acquired in ten volunteers and eig ... Full text Link to item Cite

Stereotactic body radiation therapy: the report of AAPM Task Group 101.

Journal Article Med Phys · August 2010 Featured Publication Task Group 101 of the AAPM has prepared this report for medical physicists, clinicians, and therapists in order to outline the best practice guidelines for the external-beam radiation therapy technique referred to as stereotactic body radiation therapy (SB ... Full text Link to item Cite

Arc-modulated radiation therapy based on linear models.

Journal Article Phys Med Biol · July 7, 2010 Featured Publication This paper reports an inverse arc-modulated radiation therapy planning technique based on linear models. It is implemented with a two-step procedure. First, fluence maps for 36 fixed-gantry beams are generated using a linear model-based intensity-modulated ... Full text Link to item Cite

Kilovoltage cone-beam CT: comparative dose and image quality evaluations in partial and full-angle scan protocols.

Journal Article Med Phys · July 2010 Featured Publication PURPOSE: To assess imaging dose of partial and full-angle kilovoltage CBCT scan protocols and to evaluate image quality for each protocol. METHODS: The authors obtained the CT dose index (CTDI) of the kilovoltage CBCT protocols in an on-board imager by ion ... Full text Link to item Cite

Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages.

Journal Article FEBS Lett · June 3, 2010 Macrophages play a key role in innate immune response to pathogens and in tissue homeostasis, inflammation and repair. A serpin A3G (SpiA3G) is highly induced in classically activated macrophages. We show increased localization of SpiA3G in the nucleolus a ... Full text Link to item Cite

Estimation of computed tomography dose index in cone beam computed tomography: MOSFET measurements and Monte Carlo simulations.

Journal Article Health Phys · May 2010 Featured Publication To address the lack of accurate dose estimation method in cone beam computed tomography (CBCT), we performed point dose metal oxide semiconductor field-effect transistor (MOSFET) measurements and Monte Carlo (MC) simulations. A Varian On-Board Imager (OBI) ... Full text Link to item Cite

6D image guidance for spinal non-invasive stereotactic body radiation therapy: Comparison between ExacTrac X-ray 6D with kilo-voltage cone-beam CT.

Journal Article Radiother Oncol · April 2010 Featured Publication PURPOSE: To investigate setup discrepancies measured with ExacTrac X-ray 6 degree-of-freedom (6D) and cone-beam computed tomography (CBCT) for patients under treatments of stereotactic body radiation therapy (SBRT). MATERIALS AND METHODS: In this work, pha ... Full text Link to item Cite

Radiotherapy treatment plans with RapidArc for prostate cancer involving seminal vesicles and lymph nodes.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2010 Featured Publication PURPOSE: Dosimetric results and treatment delivery efficiency of RapidArc plans to those of conventional intensity-modulated radiotherapy (IMRT) plans were compared using the Eclipse treatment planning system for high-risk prostate cancer. MATERIALS AND ME ... Full text Link to item Cite

Estimation of absorbed doses from paediatric cone-beam CT scans: MOSFET measurements and Monte Carlo simulations.

Journal Article Radiat Prot Dosimetry · March 2010 Featured Publication The purpose of this study was to establish a dose estimation tool with Monte Carlo (MC) simulations. A 5-y-old paediatric anthropomorphic phantom was computed tomography (CT) scanned to create a voxelised phantom and used as an input for the abdominal cone ... Full text Link to item Cite

Accelerating non-contrast-enhanced MR angiography with inflow inversion recovery imaging by skipped phase encoding and edge deghosting (SPEED).

Journal Article J Magn Reson Imaging · March 2010 Featured Publication PURPOSE: To accelerate non-contrast-enhanced MR angiography (MRA) with inflow inversion recovery (IFIR) with a fast imaging method, Skipped Phase Encoding and Edge Deghosting (SPEED). MATERIALS AND METHODS: IFIR imaging uses a preparatory inversion pulse t ... Full text Link to item Cite

Slow gantry rotation acquisition technique for on-board four-dimensional digital tomosynthesis.

Journal Article Med Phys · February 2010 Featured Publication PURPOSE: Four-dimensional cone-beam computed tomography (4D CBCT) has been investigated for motion imaging in the radiotherapy treatment room. The drawbacks of 4D CBCT are long scan times and high imaging doses. The aims of this study were to develop and i ... Full text Link to item Cite

A methodology for selecting the beam arrangement to reduce the intensity-modulated radiation therapy (IMRT) dose to the SPECT-defined functioning lung.

Journal Article Phys Med Biol · January 21, 2010 Featured Publication Macroaggregated albumin single-photon emission computed tomography (MAA-SPECT) provides a map of the spatial distribution of lung perfusion. Our previous work developed a methodology to use SPECT guidance to reduce the dose to the functional lung in IMRT p ... Full text Link to item Cite

Similarities between static and rotational intensity-modulated plans.

Journal Article Phys Med Biol · January 7, 2010 Featured Publication The aim of this study was to explore similarities between intensity-modulated radiotherapy (IMRT) and intensity-modulated arc therapy (IMAT) techniques in the context of the number of multi-leaf collimator (MLC) segments required to achieve plan objectives ... Full text Link to item Cite

SU‐GG‐I‐140: Maximum Intensity Projection (MIP) Imaging Using Multi‐Slice Cine MRI

Conference Medical Physics · January 1, 2010 Purpose: To propose a novel method of acquiring Maximum Intensity Projection (MIP) images using multi‐slice cine MRI, termed as MRI‐MIP, and to evaluate its feasibility in quantifying motion magnitude. Materials and Methods: MRI‐MIP images are acquired usi ... Full text Cite

SU‐GG‐T‐483: Does Breath‐Hold Immobilization Affect Tumor Radioresistance in Breast?

Conference Medical Physics · January 1, 2010 Purpose: A 15–30s Breath Hold (BH) is often used in radiation therapy for breast cancer patients to minimize heart dose, however its effect on tumor oxygenation and radiosensitivity is unknown. The purpose of this study is to utilize published data on the ... Full text Cite

TU‐A‐204B‐04: A Technique to Correct Crescent Artifacts in On‐Board CBCT

Conference Medical Physics · January 1, 2010 Purpose: Large dark and bright crescents are commonly seen in cone‐beam (CB) CT images acquired onboard radiation therapy machines. The purpose of this project is to develop a technique for removing this artifact. Method and Materials: We propose that cres ... Full text Cite

TU‐C‐204B‐06: Performance Evaluation of a Dual Cone‐Beam CT (Dual CBCT) System

Conference Medical Physics · January 1, 2010 Purpose: Very little information is available for clinical CBCT imaging using a dual‐detector system. This study assesses the performance of a recently developed bench‐top dual large‐flat‐panel detectors cone beam computed tomography (CBCT) system and to c ... Full text Cite

SU‐GG‐J‐80: Characterization of Cross Scatter in Dual Source CBCT

Conference Medical Physics · January 1, 2010 Purpose: A dual‐source CBCT imaging system provides an efficient means to perform 3D and 4D imaging, but the addition of the second imaging chain produces additional scattered photons or cross scatter. The purpose of this study is to characterize cross sca ... Full text Cite

SU‐GG‐T‐136: Treatment Plans Comparison with Static‐Gantry IMRT and RapidArcTM for Head‐And‐Neck Cancers Involving Cervical Lymph Nodes

Conference Medical Physics · January 1, 2010 Purpose: To compare the dosimetric results and treatment efficiency of intensity modulated arc therapy using RapidArc™ to static‐gantry IMRT plans for conventional fractionation treatment of head‐and‐neck cancer. Materials and Methods: This study evaluated ... Full text Cite

SU‐GG‐T‐530: Comparison of Coplanar and Non‐Coplanar Intensity Modulated Arc Techniques for Treatment of Intracranial Multi‐Focal Stereotactic Radiosurgery

Conference Medical Physics · January 1, 2010 Objectives: Intensity modulated arc therapy (IMAT) can potentially be a useful technique for the treatment of multi‐focal intracranial stereotactic radiosurgery (SRS) with a single isocenter setup. This study compares the effects of coplanar and non‐coplan ... Full text Cite

SU‐GG‐J‐67: Evaluating Dynamic Magnetic Resonance Imaging Using a New Design of Phantom: Validation with Fast Megavoltage Fluoroscopic Imaging

Conference Medical Physics · January 1, 2010 Purpose: To devlope a reliable and economic phantom for motion management study and investigate its feasibility in evaluating dynamic MRI. Method and Materials: Experiments was performed using an in‐house developed phantom that consists of a platform, a lo ... Full text Cite

TU‐B‐201B‐02: Self‐Sorted Four‐Dimensional CT Using Body Volume as Respiratory Surrogate

Conference Medical Physics · January 1, 2010 Purpose: To develop a self‐sorting four‐dimensional CT (4D‐CT) technique that uses body volume as the respiratory surrogate. Method and Materials: Respiratory signals are determined by the changes in body volume at each slice location as a function of imag ... Full text Cite

SU‐GG‐I‐148: Self‐Sorted Four‐Dimensional Magnetic Resonance Imaging: A Feasibility Study

Conference Medical Physics · January 1, 2010 Purpose: Considerable imaging dose to health tissue of patient from 4D‐CT is often a concern. This study is to develop a four‐dimensional magnetic resonance imaging (4D‐MRI) technique based on retrospective sorting strategy that uses body volume as respira ... Full text Cite

SU‐GG‐I‐24: Improving IGRT Efficiency Using GPU‐Based Ultrafast Reconstruction of DTS/CBCT and DRR

Conference Medical Physics · January 1, 2010 Purpose: One challenge of on‐line image‐guided radiation therapy is requirement of immediate availability of reconstructed 3D or 4D images for evaluation. This study is to develop a highly data‐parallel version and platform of accelerating reconstruction f ... Full text Cite

SU‐GG‐J‐62: Use Winston‐Lutz Test to Check Cone Beam CT Isocenter Accuracy for Imaging Guided Intracranial Stereotactic Radiosurgery

Conference Medical Physics · January 1, 2010 Objectives: Cone beam CT (CBCT) opens the era of three dimensional (3D) imaging guided stereotactic radiosurgery (SRS). The CBCT isocenter accuracy is critical for imaging guided SRS guidance. This study analyzes the daily quality assurance (QA) results of ... Full text Cite

SU‐GG‐I‐144: Accelerating Non‐Contrast‐Enhanced MRA with Inflow Inversion Recovery by Using Skipped Phase Encoding and Edge Deghosting (SPEED)

Conference Medical Physics · January 1, 2010 Purpose: Non‐contrast‐enhanced MR angigraphy (MRA) has always been a valuable clinical tool to study vasculatural diseases. The recently arising concerns of constrast agents in contrast‐enhanced MRA encouraged more use of non‐contrast‐enhanced MRA. The aim ... Full text Cite

SU‐GG‐T‐225: Gantry‐Angle Dependence of a 2D Ion Chamber Array for IMAT QA

Conference Medical Physics · January 1, 2010 Purpose: Gantry‐angle dependence of dose measurement for intensity‐modulated arc therapy (IMAT) quality assurance (QA) using a two‐dimensional ion chamber array may be significant. A new device, the gantry angle sensor, has been provided to compensate for ... Full text Cite

SU‐GG‐T‐137: Similarities between Static and Rotational Intensity Modulated Plans

Conference Medical Physics · January 1, 2010 Purpose: To explore similarities between intensity modulated radiotherapy (IMRT) and intensity modulated arc therapy (IMAT) techniques in the context of the number of multi‐leaf collimator (MLC) segments required to achieve plan objectives, the major facto ... Full text Cite

SU‐GG‐T‐583: Dosimetric Comparison of Anisotropic Analytical and Pencil Beam Convolution Algorithms in Breast Cancer Radiation Treatment Planning

Conference Medical Physics · January 1, 2010 Purpose: The anisotropic analytical algorithm (AAA) has been shown to provide more accurate dose calculation due to 3D scatter and inhomogeneity corrections than the pencil beam convolution algorithm (PBC) for inhomogeneous anatomical regions such as lung ... Full text Cite

TH‐C‐204B‐07: Development of Image‐Guided Radiosurgery with Novalis TX for Small Animal Study

Conference Medical Physics · January 1, 2010 Purpose: Developing a protocol to accomplish small animal radiosurgery study conducted at our clinic in evaluating radiation‐induced erectile dysfunction. Method and Materials: Animals were sedated and scanned using commercial CT scanner. Scans were import ... Full text Cite

SU‐GG‐T‐362: Is Distance‐Dependent Energy Correction Needed for Dosimetric Measurements Surrounding Brachytherapy Sources?

Conference Medical Physics · January 1, 2010 Purpose: The answer depends on both the dosimeter's energy response and energy spectrum at distance (point of measurement) from the source. The latter is object of this study. Method and Materials: The spectra in water were calculated with Monte Carlo code ... Full text Cite

SU‐GG‐I‐14: A Method to Estimate Cone‐Beam CT Dose Index and Cone‐Beam Dose Length Product

Conference Medical Physics · January 1, 2010 Purpose: To characterize the cone‐beam CTDI (CBCTDI) and cone‐beam dose length product (CBDLP) by Monte Carlo (MC) technique. Method and Materials: An extended CT head phantom (60cm long) and an extended CT body phantom (90cm long) were created in our BEAM ... Full text Cite

SU‐GG‐I‐57: Dose and Image Quality Evaluation for Partial and Full‐Angle Kilovoltage Cone‐Beam CT Protocols

Conference Medical Physics · January 1, 2010 Purpose: To assess imaging dose of partial and full‐angle CBCT scan protocols, and to evaluate their image quality. Method and Materials: The CTDI of the six new CBCT protocols for Varian OBI were obtained by ion chamber (IC) measurements and Monte Carlo ( ... Full text Cite

SU‐EE‐A1‐03: Arc Modulated Radiation Therapy Based on Linear Models

Conference Medical Physics · January 1, 2010 Purpose: The challenge for implementing promising Arc Modulated Radiation Therapy (AMRT) is its effectiveness of treatment planning tools to find optimal multileaf collimator (MLC) sequence and the fluence map. This study provides a new approach to the abo ... Full text Cite

WE‐B‐BRA‐03: Adaptive Image‐Guided Radiation Therapy (AIGRT) for Hypo‐Fractionated Prostate Cancer Treatment

Conference Medical Physics · January 1, 2010 Purpose: The large fractional dose of hypo‐fractionated prostate treatment requires high accuracy of daily treatment delivery. This study analyzes the performance of an adaptive IGRT (AIGRT) technique, which combines image guidance and adaptive re‐planning ... Full text Cite

TU‐E‐BRB‐03: A Planning Quality Evaluation Tool for Adaptive IMRT Treatment Based on Machine Learning

Conference Medical Physics · January 1, 2010 Purpose: To monitor the quality of adaptive IMRT plans, especially dose sparing for the organs‐at‐risk (OARs), a plan evaluation tool is developed to predict the dose volume histogram (DVH) based on patient's anatomical information and a database of high q ... Full text Cite

SU‐GG‐J‐76: Validation of a Proposed Optimal Slow Gantry Rotation Technique for On‐Board Four‐Dimensional Imaging Using Lung Patient Data

Conference Medical Physics · January 1, 2010 Purpose: Substantial efforts have been made in recent years to develop on‐board four‐dimensional (4D) imaging techniques using gantry mounted cone‐beam imaging devices. This study validates a slow gantry rotation 4D imaging protocol using lung patient data ... Full text Cite

TH‐A‐BRA‐03: TG‐104: In‐Room kV Imaging for IGRT

Conference Medical Physics · January 1, 2010 In‐room kilovoltage (kV) x‐ray imaging refers to radiographic imaging using kV x‐ray sources in the radiation treatment room. It has been widely accepted for radiotherapy target localization and treatment intervention. Task Group 104 (TG 104) reports on th ... Full text Cite

SU‐DD‐A3‐03: How Accurately Can the Internal Target Volume (ITV) from a Free‐Breathing Cone Beam Computed Tomography (FB‐CBCT) Scan Be Used for Target Verification?

Conference Medical Physics · January 1, 2010 Purpose: An internal target volume (ITV) is often identified by acquiring a free‐breathing cone‐beam computed tomography scan (FB‐CBCT) to verify patient setup of tumors affected by respiratory motion. However, its accuracy is not well understood. The purp ... Full text Cite

Dosimetry challenges for implementing emerging technologies.

Journal Article J Phys Conf Ser · 2010 Featured Publication During the last 10 years, radiation therapy technologies have gone through major changes, mainly related introduction of sophisticated delivery and imaging techniques to improve the target localization accuracy and dose conformity. While implementation of ... Full text Link to item Cite

Radiation dose from cone beam CT in a pediatric phantom: risk estimation of cancer incidence.

Journal Article AJR Am J Roentgenol · January 2010 Featured Publication OBJECTIVE: The objective of our study was to measure absorbed doses and calculate effective dose (ED) from cone beam CT (CBCT) with metal oxide semiconductor field effect transistor (MOSFET) detectors in an anthropomorphic phantom and to estimate the risk ... Full text Link to item Cite

On-line adaptive radiation therapy: feasibility and clinical study.

Journal Article J Oncol · 2010 Featured Publication The purpose of this paper is to evaluate the feasibility and clinical dosimetric benefit of an on-line, that is, with the patient in the treatment position, Adaptive Radiation Therapy (ART) system for prostate cancer treatment based on daily cone-beam CT i ... Full text Open Access Link to item Cite

Patient specific quality assurance: Transition from IMRT to IMAT

Journal Article Journal of Physics: Conference Series · January 1, 2010 Featured Publication The purpose of this study was to test a patient-specific quality assurance (QA) protocol for intensity-modulated arc radiotherapy (IMAT), and to evaluate the use of an intensity-modulated stationary radiotherapy QA device (2D ion chamber array). Thirty-nin ... Full text Cite

ExacTrac X-ray 6 degree-of-freedom image-guidance for intracranial non-invasive stereotactic radiotherapy: comparison with kilo-voltage cone-beam CT.

Journal Article Radiother Oncol · December 2009 Featured Publication BACKGROUND AND PURPOSE: To compare the residual setup errors measured with ExacTrac X-ray 6 degree-of-freedom (6D) and cone-beam computed tomography (CBCT) for a head phantom and patients receiving intracranial non-invasive fractionated stereotactic radiot ... Full text Link to item Cite

Volumetric arc intensity-modulated therapy for spine body radiotherapy: comparison with static intensity-modulated treatment.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2009 Featured Publication PURPOSE: This clinical study evaluates the feasibility of using volumetric arc-modulated treatment (VMAT) for spine stereotactic body radiotherapy (SBRT) to achieve highly conformal dose distributions that spare adjacent organs at risk (OAR) with reduced t ... Full text Link to item Cite

Evaluating the Commissioning and QA of Intensity Modulated Arc Therapy using a Benchmark IMRT Planning Suite

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Slow Gantry Rotation 4D Digital Tomosynthesis for Lung Motion Imaging

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

On-board SPECT Imaging: Improved Target Localization via Spatial Resolution Compensation

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Six-dimensional Image Guidance for Spinal Noninvasive SRS/SBRT: Comparison between ExacTrac X-ray 6D with kV Cone-beam CT

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Imaging Guided Stereotactic Radiosurgery and its Accuracy Compared to Frame-based Localization

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Can Biological Optimization Be Incorporated into the Current Clinical Treatment Planning Workflow?

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Hybrid IGRT Technique for Prostate Hypofractionation

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Treatment Plan Comparison between IMRT and Volumetric IMAT using One- and Two-arc Beams for Prostate Cancer

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Apparatus-dependent Differences in Spine Stereotactic Body Radiosurgery (SBRT) Dosimetry

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Quantitative Study of Geometrical Distortion in Cone-beam CT Images Reconstructed using FDK Algorithm

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Comparing Static vs. Rotational IMRT for Spine Body Radiotherapy

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Evaluation of In-Room Cone-Beam CT Imaging Techniques Compared to CT for Dose Calculation

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

A positioning QA procedure for 2D/2D (kV/MV) and 3D/3D (CT/CBCT) image matching for radiotherapy patient setup.

Journal Article J Appl Clin Med Phys · October 6, 2009 Featured Publication A positioning QA procedure for Varian's 2D/2D (kV/MV) and 3D/3D (planCT/CBCT) matching was developed. The procedure was to check: (1) the coincidence of on-board imager (OBI), portal imager (PI), and cone beam CT (CBCT)'s isocenters (digital graticules) to ... Full text Open Access Link to item Cite

Development of a neuro-fuzzy technique for automated parameter optimization of inverse treatment planning.

Journal Article Radiat Oncol · September 25, 2009 Featured Publication BACKGROUND: Parameter optimization in the process of inverse treatment planning for intensity modulated radiation therapy (IMRT) is mainly conducted by human planners in order to create a plan with the desired dose distribution. To automate this tedious pr ... Full text Open Access Link to item Cite

Tradeoffs of integrating real-time tracking into IGRT for prostate cancer treatment.

Journal Article Phys Med Biol · September 7, 2009 Featured Publication This study investigated the integration of the Calypso real-time tracking system, based on implanted ferromagnetic transponders and a detector array, into the current process for image-guided radiation treatment (IGRT) of prostate cancer at our institution ... Full text Link to item Cite

Task Group 142 report: quality assurance of medical accelerators.

Journal Article Med Phys · September 2009 Featured Publication The task group (TG) for quality assurance of medical accelerators was constituted by the American Association of Physicists in Medicine's Science Council under the direction of the Radiation Therapy Committee and the Quality Assurance and Outcome Improveme ... Full text Link to item Cite

American Society of Radiation Oncology recommendations for documenting intensity-modulated radiation therapy treatments.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 2009 Featured Publication Despite the widespread use of intensity-modulated radiation therapy (IMRT) for approximately a decade, a lack of adequate guidelines for documenting these treatments persists. Proper IMRT treatment documentation is necessary for accurate reconstruction of ... Full text Link to item Cite

Advances in technology for intracranial stereotactic radiosurgery.

Journal Article Technol Cancer Res Treat · August 2009 Featured Publication Stereotactic radiosurgery (SRS) refers to a single radiation treatment delivering a high dose to an intra-cranial target localized in three-dimensions by CT and/or MRI imaging. Traditionally, immobilization of the patient's head has been achieved using a r ... Full text Link to item Cite

Comparison of online IGRT techniques for prostate IMRT treatment: adaptive vs repositioning correction.

Journal Article Med Phys · May 2009 Featured Publication This study compares three online image guidance techniques (IGRT) for prostate IMRT treatment: bony-anatomy matching, soft-tissue matching, and online replanning. Six prostate IMRT patients were studied. Five daily CBCT scans from the first week were acqui ... Full text Link to item Cite

On-board SPECT for localizing functional targets: a simulation study.

Journal Article Med Phys · May 2009 Featured Publication Single photon emission computed tomography (SPECT) was investigated for imaging on-board radiation therapy machines in order to localize functional and molecular targets. A computer-simulated female NCAT phantom was positioned supine on a flat-top treatmen ... Full text Link to item Cite

Ice as a water-equivalent solid medium for brachytherapy dosimetric measurements.

Journal Article Radiat Environ Biophys · April 2009 Featured Publication Precise positioning of source and dosimeters is essential in the experimental determination of dosimetric characteristics of brachytherapy sources. Various near-water equivalent solid phantoms have been used to achieve the necessary precision in the positi ... Full text Link to item Cite

Stereotactic body radiotherapy for lesions of the spine and paraspinal regions.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2009 Featured Publication PURPOSE: To describe our experience and clinical strategy for stereotactic body radiotherapy (SBRT) of spinal lesions. METHODS AND MATERIALS: Thirty-two patients with 33 spinal lesions underwent computed tomography-based simulation while free breathing. Gr ... Full text Link to item Cite

Tracking brachytherapy sources using emission imaging with one flat panel detector.

Journal Article Med Phys · April 2009 Featured Publication This work proposes to use the radiation from brachytherapy sources to track their dwell positions in three-dimensional (3D) space. The prototype device uses a single flat panel detector and a BB tray. The BBs are arranged in a defined pattern. The shadow o ... Full text Link to item Cite

Comparing digital tomosynthesis to cone-beam CT for position verification in patients undergoing partial breast irradiation.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2009 Featured Publication PURPOSE: To evaluate digital tomosynthesis (DTS) technology for daily positioning of patients receiving accelerated partial breast irradiation (APBI) and to compare the positioning accuracy of DTS to three-dimensional cone-beam computed tomography (CBCT). ... Full text Link to item Cite

Refinement of treatment setup and target localization accuracy using three-dimensional cone-beam computed tomography for stereotactic body radiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2009 Featured Publication PURPOSES: To quantitatively compare two-dimensional (2D) orthogonal kV with three-dimensional (3D) cone-beam CT (CBCT) for target localization; and to assess intrafraction motion with kV images in patients undergoing stereotactic body radiotherapy (SBRT). ... Full text Link to item Cite

Impact of collimator leaf width and treatment technique on stereotactic radiosurgery and radiotherapy plans for intra- and extracranial lesions.

Journal Article Radiat Oncol · January 21, 2009 Featured Publication BACKGROUND: This study evaluated the dosimetric impact of various treatment techniques as well as collimator leaf width (2.5 vs 5 mm) for three groups of tumors -- spine tumors, brain tumors abutting the brainstem, and liver tumors. These lesions often pre ... Full text Open Access Link to item Cite

Impact of collimator leaf width and treatment technique on stereotactic radiosurgery and radiotherapy plans for intra- and extracranial lesions

Journal Article Radiation Oncology · January 21, 2009 Featured Publication Background: This study evaluated the dosimetric impact of various treatment techniques as well as collimator leaf width (2.5 vs 5 mm) for three groups of tumors - spine tumors, brain tumors abutting the brainstem, and liver tumors. These lesions often pres ... Full text Cite

SU‐FF‐T‐498: Improving Normal Tissue Complication Probability Fits Using Non‐Binary Outcomes

Conference Medical Physics · January 1, 2009 Purpose: Binary outcomes (toxicity=1, no‐toxicity=0) are frequently used as inputs to fit parametric models. However, in reality, outcomes span the range in‐between these extremes; binary values are used for lack of more precise quantification. We propose ... Full text Cite

TH‐B‐BRC‐01: Tools for IMRT Commissioning: Static and Rotating Gantries

Conference Medical Physics · January 1, 2009 Commissioning an IMRT system refers to the initial verification by phantom studies that treatments can be planned, prepared, and delivered with sufficient accuracy. Our profession has struggled since the inception of IMRT to define what measurements to mak ... Full text Cite

SU‐FF‐T‐309: Quality Assurance for Imaging Guided Stereotactic RadioSurgery with Novalis Tx™ System

Conference Medical Physics · January 1, 2009 Purpose: To present QA measurements over extended periods at our institute and recommend a QA program for image‐guided radiosurgery on Novalis Tx system. Method and Materials: Novalis Tx system is developed based on a Trilogy linear accelerator featuring B ... Full text Cite

SU‐FF‐T‐322: Geometric Calibration of a Dual Cone Beam CT System with Large Flat Panel Detectors

Conference Medical Physics · January 1, 2009 Purpose: To assess errors in a simple visual alignment of a dual large‐flat‐panel, cone‐beam‐CT (CBCT) system, and to obtain misalignment parameters that can be incorporated into image reconstruction for accurate target localization in image‐guided radiati ... Full text Cite

SU‐FF‐J‐09: Limited‐Angle Imaging for Target Positioning Using Orthogonal Conebeam X‐Ray Systems

Conference Medical Physics · January 1, 2009 Purpose: To investigate limited‐angle imaging using orthogonal x‐ray systems, with regard to use for target positioning onboard external beam radiation therapy (EBRT) machines. Method and Materials: Image reconstruction was performed using projection data ... Full text Cite

SU‐FF‐J‐02: Impact of Cross Scatter On CNR in Fluoroscopic Images Taken with a Dual Flat Panel X‐Ray Imaging System

Conference Medical Physics · January 1, 2009 Purpose: To examine the impact of cross scatter on contrast‐to‐noise ratio (CNR) in fluoroscopic images acquired with a dual flat‐panel x‐ray imaging system. Method and Materials: An x‐ray imaging system has been developed consisting of two tube/detector p ... Full text Cite

SU‐FF‐T‐130: Radiotherapy Treatment Plans with RapidArc for Head‐And‐Neck Cancer

Conference Medical Physics · January 1, 2009 Purpose: The purpose of this study is to compare RapidArc plans and conventional IMRT plans for head‐and‐neck cancer treatment involving bilateral nodes. Methods and Materials: This study included 10 locally advanced head‐and‐neck cancer patients. The plan ... Full text Cite

SU‐EE‐A3‐02: Imaging Guided Frameless Stereotactic RadioSurgery Using CBCT 6D Image Registration and 6D Couch On Novalis Tx™ System

Conference Medical Physics · January 1, 2009 Purpose: To investigate localization accuracy for image‐guided frameless stereotactic‐radiosurgery (IG‐SRS) using CBCT 6D image registration and 6D‐couch on Novalis Tx system. Method and Materials: Novalis Tx system is a powerful radiosurgery system featur ... Full text Cite

SU‐FF‐T‐545: Feasibility Study for Treatment of Intracranial Multi‐Focal Stereotactic Radiosurgery with Multiple Intensity Modulated Arc Technique

Conference Medical Physics · January 1, 2009 Objectives: To investigate the feasibility of using an intensity modulated arc technique for multi‐focal intracranial stereotactic radiosurgery with a single isocenter setup to significantly decrease the treatment time. Methods: A Novalis Tx linear acceler ... Full text Cite

SU‐FF‐T‐548: Comparison of Cone‐Beam CT and Frame‐Based Localizations for Stereotactic Radiosurgery with Fixed Head Rings and Removable Frames

Conference Medical Physics · January 1, 2009 Objectives: To compare localization accuracy using both conventional frame‐based localizers and cone‐beam CT (CBCT) images for stereotactic radiosurgery (SRS). Methods: A SRS geometric phantom was used to verify the localization accuracy based on a SRS loc ... Full text Cite

SU‐FF‐T‐301: Clinical Implementation and Commission of Volumetric Modulated Arc Therapy

Conference Medical Physics · January 1, 2009 Purpose Volumetric modulated arc therapy (VMAT) is a rotational IMRT modality that combines dose rate modulation with gantry and MLC motion, thereby increasing the complexity of IMRT delivery. Effective implementation of this technology is still quite new ... Full text Cite

SU‐FF‐T‐314: Patient‐Specific Quality Assurance Techniques for RapidArc Radiotherapy

Conference Medical Physics · January 1, 2009 Purpose: To develop a patient‐specific quality assurance protocol for RapidArc™ radiotherapy. Method and Materials: Following the commissioning of RapidArc™ treatment delivery, we tested several methods of patient‐specific quality assurance (QA). Ion chamb ... Full text Cite

SU‐FF‐J‐56: Integrating Real‐Time Tracking Into Image Guided Radiation Therapy for Prostate Cancer Treatment

Conference Medical Physics · January 1, 2009 Purpose: To investigate how a real‐time tracking technique, based on implanted transponders, could be effectively integrated into the current process for image‐guided radiation treatment of prostate cancer. Method and Materials: Current prostate IGRT proce ... Full text Cite

SU‐FF‐T‐158: A Method to Overlay Biological Optimization On Traditional Dose‐Volume Constrained Intensity Modulated Radiotherapy (IMRT) Optimization

Conference Medical Physics · January 1, 2009 Purpose: Biological optimization for IMRT planning is typically not clinically utilized, perhaps due to uncertainties associated with normal tissue complication models. Clinically, IMRT planning still relies heavily on dose‐volume constraints. We propose a ... Full text Cite

SU‐FF‐I‐56: Radiation Dose Estimation From Pediatric Cone Beam Computed Tomography

Conference Medical Physics · January 1, 2009 Purpose: To estimate absorbed doses and effective dose (ED) from cone beam computed tomography (CBCT) with metal oxide semiconductor field effect transistor (MOSFET) detectors in an anthropomorphic phantom, and to estimate the risk of cancer incidence from ... Full text Cite

TH‐A‐211A‐01: Digital Tomosynthesis for Target Localization

Conference Medical Physics · January 1, 2009 Any deviation between treated and planned volumes for 3‐D conformal therapy, such as IMRT, may cause an adverse clinical outcome. It is therefore critical to minimize all potential deviations using an on‐board (or real‐time) imaging procedure immediately p ... Full text Cite

SU‐FF‐T‐673: Application of RapidArc Technique to Cervical Spine Stereotactic Treatment

Conference Medical Physics · January 1, 2009 Purpose: Cervical spine (C‐spine) lesions are located more centrally than the rest of the spinal column making the c‐spine an ideal target for the RapidArc therapy technique. In this study, we explore the use of RapidArc to treat c‐spine patients and inves ... Full text Cite

SU‐FF‐T‐567: Volumetric Modulated Arc Therapy for Spine Body Radiotherapy: Comparison with Static Intensity Modulated Treatment

Conference Medical Physics · January 1, 2009 Purpose: Volumetric modulated arc treatment (VMAT) reduces treatment time over static beam intensity modulated treatment (IMRT) by delivering IMRT using arcs. This clinical study evaluates the feasibility of using VMAT for spine stereotactic body radiother ... Full text Cite

SU‐FF‐J‐55: Acceptance Testing and Quality‐Assurance Protocols for the Calypso® 4D Localization System™ and Q‐Fix®/Calypso® Couchtop

Conference Medical Physics · January 1, 2009 Purpose: To develop quality‐assurance (QA) protocols for the Calypso® 4D Localization System including acceptance testing, commissioning, daily QA, monthly QA, and annual QA. Method and Materials: The following acceptance testing/commissioning/QA protocols ... Full text Cite

SU‐FF‐T‐80: Hybrid Image Guided Radiation Therapy for Hypofractionated Prostate IMRT: Feasibility Study

Conference Medical Physics · January 1, 2009 Purpose: In prostate IGRT employing hypofractionation, two methods are commonly used: patient re‐positioning and re‐planning. We propose a hybrid IGRT technique in this study. The dosimetric benefits and efficiency improvement of the technique is quantitat ... Full text Cite

SU‐FF‐T‐574: Radiotherapy Treatment Plans with RapidArc for Prostate Cancer Involving Seminal Vesicles

Conference Medical Physics · January 1, 2009 Purpose: The purpose of this report is to compare RapidArc plans and conventional IMRT plans for prostate cancer involving seminal vesicles. Methods and Materials: This study included 10 patients. The planning‐target volume (PTV) contained the prostate and ... Full text Cite

SU‐FF‐T‐223: A New IMRT/RapidArc QA Procedure Utilizing MLC Dynalog Files

Conference Medical Physics · January 1, 2009 Purpose: To develop a quick and efficient patient‐specific QA procedure for both IMRT and RapidArc using MLC dynalog files. Method and Materials: MLC dynalog files record both planned and actual MLC leaf positions, actual fractional MU and gantry angle. Th ... Full text Cite

SU‐FF‐J‐12: HU and Dosimetric Comparison of Six Cone‐Beam CT Acquisition Techniques for Radiation Therapy Planning

Conference Medical Physics · January 1, 2009 Purpose: It has been shown that cone‐beam computed tomography (CBCT) can be used in dose calculation for treatment planning. This study investigates the HU and dosimetric properties of six CBCT techniques in comparison with conventional CT to determine whi ... Full text Cite

TU‐C‐303A‐04: Slow Gantry Rotation Acquisition Protocol for Four‐Dimensional Digital Tomosynthesis

Conference Medical Physics · January 1, 2009 Purpose: Four‐dimensional digital tomosynthesis (4D‐DTS) was recently introduced as a novel on‐board 4D imaging technique. The purpose of this study is to develop and implement a slow gantry rotation acquisition protocol for 4D‐DTS. A formalism for determi ... Full text Cite

Efficient multiple acquisitions by Skipped Phase Encoding and Edge Deghosting (SPEED) using shared spatial information.

Journal Article Magn Reson Med · January 2009 Featured Publication The fast MRI method of Skipped Phase Encoding and Edge Deghosting (SPEED) is further developed to accelerate multiple acquisitions. In a single acquisition, SPEED first acquires three sparse ghosted edge maps with an undersampling factor of N/3, which are ... Full text Link to item Cite

Clinical evaluation of positioning verification using digital tomosynthesis and bony anatomy and soft tissues for prostate image-guided radiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2009 Featured Publication PURPOSE: To evaluate on-board digital tomosynthesis (DTS) for patient positioning vs. two-dimensional (2D) radiography and three-dimensional cone beam (CBCT). METHODS AND MATERIALS: A total of 92 image sessions from 9 prostate cancer patients were analyzed ... Full text Link to item Cite

A positioning QA procedure for 2D/2D (kV/MV) and 3D/3D (CT/CBCT) image matching for radiotherapy patient setup

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2009 Featured Publication A positioning QA procedure for Varian's 2D/2D (kV/MV) and 3D/3D (planCT/CBCT) matching was developed. The procedure was to check: (1) the coincidence of on-board imager (OBI), portal imager (PI), and cone beam CT (CBCT)'s isocenters (digital graticules) to ... Full text Cite

Analysis of image quality for real-time target tracking using simultaneous kV-MV imaging.

Journal Article Med Phys · December 2008 Featured Publication Real-time tracking can provide high accuracy localization for a moving target and minimize the effect of motion. Simultaneous kV-MV imaging has been proposed as a real-time tracking technique by utilizing the existing kV on-board imager (OBI) and the MV el ... Full text Link to item Cite

Decision fusion of machine learning models to predict radiotherapyinduced lung pneumonitis

Journal Article Proceedings - 7th International Conference on Machine Learning and Applications, ICMLA 2008 · December 1, 2008 Featured Publication Combining different machine learning models (decision fusion) has been shown to be an effective method for estimating the underlying physical mechanism by allowing the models to reinforce each other when consensus exists, or, conversely, negate each other ... Full text Cite

Combining multiple models to generate consensus: application to radiation-induced pneumonitis prediction.

Journal Article Med Phys · November 2008 Featured Publication The fusion of predictions from disparate models has been used in several fields to obtain a more realistic and robust estimate of the "ground truth" by allowing the models to reinforce each other when consensus exists, or, conversely, negate each other whe ... Full text Link to item Cite

Dosimetric characteristics of novalis Tx system with high definition multileaf collimator.

Journal Article Med Phys · October 2008 Featured Publication A new Novalis Tx system equipped with a high definition multileaf collimator (HDMLC) recently became available to perform both image-guided radiosurgery and conventional radiotherapy. It is capable of delivering a highly conformal radiation dose with three ... Full text Link to item Cite

High-definition Micro-multileaf Collimator in Radiosurgery Treatment Planning for Arteriovenous Malformations

Conference International Journal of Radiation Oncology*Biology*Physics · September 2008 Full text Cite

Dosimetrical Evaluation of SRS/SBRT Techniques

Conference International Journal of Radiation Oncology*Biology*Physics · September 2008 Full text Cite

Can Cone Beam CT Replace Frame-based Localization for Stereotactic Radiosurgery?

Conference International Journal of Radiation Oncology*Biology*Physics · September 2008 Full text Cite

A Novel Digital Tomosynthesis (DTS) Reconstruction Method using Prior Information and a Deformation Model

Conference International Journal of Radiation Oncology*Biology*Physics · September 2008 Full text Cite

Dosimetrical Evaluation of an Online Adaptive IMRT Technique

Conference International Journal of Radiation Oncology*Biology*Physics · September 2008 Full text Cite

On-board four-dimensional digital tomosynthesis: first experimental results.

Journal Article Med Phys · August 2008 Featured Publication The purpose of this study is to propose four-dimensional digital tomosynthesis (4D-DTS) for on-board analysis of motion information in three dimensions. Images of a dynamic motion phantom were reconstructed using acquisition scan angles ranging from 20 deg ... Full text Link to item Cite

A novel digital tomosynthesis (DTS) reconstruction method using a deformation field map.

Journal Article Med Phys · July 2008 Featured Publication We developed a novel digital tomosynthesis (DTS) reconstruction method using a deformation field map to optimally estimate volumetric information in DTS images. The deformation field map is solved by using prior information, a deformation model, and new pr ... Full text Link to item Cite

Evaluation of an electron Monte Carlo dose calculation algorithm for electron beam.

Journal Article J Appl Clin Med Phys · June 23, 2008 Featured Publication The electron Monte Carlo (eMC) dose calculation algorithm of the Eclipse treatment planning system is based heavily upon Monte Carlo simulation of the linac head and modeling of the linac beam characteristics with minimal measurement of beam data. Commissi ... Full text Open Access Link to item Cite

[Characteristics and affecting factors of denitrifying phosphorus removal in two-sludge sequencing batch reactor].

Journal Article Huan Jing Ke Xue · June 2008 Featured Publication The characteristics of denitrifying phosphorus removal in a lab-scale two-sludge anaerobic-anoxic/nitrification SBR (A2 NSBR) system were studied fed with domestic wastewater. The influence of some key operation parameters, like C/P, C/N, and HRT, were exa ... Link to item Cite

Fast reconstruction of digital tomosynthesis using on-board images.

Journal Article Med Phys · May 2008 Featured Publication Digital tomosynthesis (DTS) is a method to reconstruct pseudo three-dimensional (3D) volume images from two-dimensional x-ray projections acquired over limited scan angles. Compared with cone-beam computed tomography, which is frequently used for 3D image ... Full text Link to item Cite

The application of distance transformation on parameter optimization of inverse planning in intensity-modulated radiation therapy.

Journal Article J Appl Clin Med Phys · April 16, 2008 Featured Publication In inverse planning for intensity-modulated radiation therapy (IMRT), the dose specification and related weighting factor of an objective function for involved organs is usually predefined by a single value and then iteratively optimized, subject to a set ... Full text Open Access Link to item Cite

The investigation on the location effect of external markers in respiratory-gated radiotherapy.

Journal Article J Appl Clin Med Phys · April 16, 2008 Featured Publication PURPOSE: To investigate the effect of the marker placement on the correlation relationship between the motions of external markers and the internal target under different breathing patterns for several lung cancer patients. METHOD AND MATERIAL: To monitor ... Full text Open Access Link to item Cite

The impact of respiratory motion and treatment technique on stereotactic body radiation therapy for liver cancer.

Journal Article Med Phys · April 2008 Featured Publication Stereotactic body radiation therapy (SBRT), which delivers a much higher fractional dose than conventional treatment in only a few fractions, is an effective treatment for liver metastases. For patients who are treated under free-breathing conditions, howe ... Full text Link to item Cite

Integration of cone-beam CT in stereotactic body radiation therapy.

Journal Article Technol Cancer Res Treat · April 2008 Featured Publication This report describes the technique and initial experience using cone beam CT (CBCT) for localization of treatment targets in patients undergoing stereotactic body radiation therapy (SBRT). Patients selected for SBRT underwent 3-D or 4-D CT scans in a cust ... Full text Link to item Cite

Assessment of the residual error in soft tissue setup in patients undergoing partial breast irradiation: results of a prospective study using cone-beam computed tomography.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2008 Featured Publication PURPOSE: On-board cone-beam computed tomography (CBCT) provides soft tissue information that may improve setup accuracy in patients undergoing accelerated partial breast irradiation (APBI). We used CBCT to assess the residual error in soft tissue after two ... Full text Link to item Cite

On-line re-optimization of prostate IMRT plans for adaptive radiation therapy.

Journal Article Phys Med Biol · February 7, 2008 Featured Publication For intermediate and high risk prostate cancer, both the prostate gland and seminal vesicles are included in the clinical target volume. Internal motion patterns of these two organs vary, presenting a challenge for adaptive treatment. Adaptive techniques s ... Full text Link to item Cite

Automatic registration between reference and on-board digital tomosynthesis images for positioning verification.

Journal Article Med Phys · February 2008 Featured Publication The authors developed a hybrid multiresolution rigid-body registration technique to automatically register reference digital tomosynthesis (DTS) images with on-board DTS images to guide patient positioning in radiation therapy. This hybrid registration tec ... Full text Link to item Cite

Clinical assessment and characterization of a dual tube kilovoltage X-ray localization system in the radiotherapy treatment room.

Journal Article J Appl Clin Med Phys · January 13, 2008 Featured Publication INTRODUCTION: Although flat-panel based X-ray imaging has been well tested in diagnostic radiology, its use as an image-guided-radiotherapy (IGRT) system in a treatment room is new and requires systematic assessment. MATERIALS AND METHODS: BrainLab Novalis ... Full text Open Access Link to item Cite

Using patient data similarities to predict radiation pneumonitis via a self-organizing map.

Journal Article Phys Med Biol · January 7, 2008 Featured Publication This work investigates the use of the self-organizing map (SOM) technique for predicting lung radiation pneumonitis (RP) risk. SOM is an effective method for projecting and visualizing high-dimensional data in a low-dimensional space (map). By projecting p ... Full text Link to item Cite

SU‐GG‐T‐406: Improving Lung Radiation‐Pneumonitis Prediction by Combining Different Models

Conference Medical Physics · January 1, 2008 Purpose: Combining the results of methodologically different models (decision fusion) has been shown to yield a fused result that more truthfully represents the underlying phenomenon, compared to the individual models. In this work, we study the effect of ... Full text Cite

WE‐C‐AUD B‐05: Predicting Radiation‐Induced Cardiac Perfusion Defects Using a Fusion Model

Conference Medical Physics · January 1, 2008 Purpose: To predict radiation‐induced cardiac perfusion defects using a fusion model that combines the results of four separate models: feed‐forward neural networks (NNET), self‐organizing maps (SOM), support vector machines (SVM), and multivariate adaptiv ... Full text Cite

SU‐GG‐J‐156: Quantitative Analysis of Onboard SPECT Imaging Using Compact Gamma Cameras

Conference Medical Physics · January 1, 2008 Purpose: Single photon emission computed tomography (SPECT) imaging on‐board radiation therapy machines may enhance radiation therapy. Use of a light‐weight, compact detector would be desirable because of maneuverability, yet is challenged by truncation an ... Full text Cite

SU‐GG‐T‐38: Tracking of Brachytherapy Source Position Using Emission Imaging

Conference Medical Physics · January 1, 2008 Purpose: To construct an imaging system that uses the exit radiation from a brachytherapy source during treatment. This system uses a single flat panel detector (FPD) and is capable of tracking the source position in 3D space, with no extra imaging radiati ... Full text Cite

SU‐GG‐T‐446: Dosimetric Characteristics of High Definition Multi‐Leaf Collimator

Conference Medical Physics · January 1, 2008 Purpose: A new type of high‐definition multi‐leaf collimator (HD 120 MLC, Varian Medical Systems) is being introduced into clinical practice to improve the conformality of stereotactic radiation therapy and radiosurgery. Its leaf width at isocenter is 2.5 ... Full text Cite

SU‐GG‐T‐454: Localization Accuracy of Cone‐Beam CT Guided Radiosurgery as Investigated Utilizing a Geometric Phantom

Conference Medical Physics · January 1, 2008 Purpose: While the advantage of imaging guidance with cone beam CT (CBCT) guided radiosurgery is obvious, the localization accuracy of CBCT guided radiosurgery still remains a concern. This study utilized a geometric phantom with known target positions to ... Full text Cite

SU‐GG‐J‐177: The Application of An ASi‐Based EPID to Guide Intensity Modulated Radiation Therapy (IMRT) of Head‐And‐Neck Cancer

Conference Medical Physics · January 1, 2008 Purpose: In head‐and‐neck IMRT treatment, doses to targets and critical organs are affected by many factors including patient positioning, weight loss and tumor shrinkage. To ensure therapeutic effectiveness, re‐planning with a new CT is often conducted. H ... Full text Cite

SU‐EE‐A4‐04: Accelerating Breast Dynamic Contrast Enhanced MRI with Efficient Multiple Acquisitions by SPEED Using Shared Information

Conference Medical Physics · January 1, 2008 Purpose: The efficient multiple acquisition method using Skipped Phase Encoding and Edge Deghosting (SPEED) has been successfully demonstrated with a dynamic contrast enhanced (CE) mice tumor study; however, it has not been tested with any human subjects. ... Full text Cite

MO‐D‐351‐07: A System to Dynamically Balance Dose Sparing Between Critical Structures in Intensity Modulated Radiation Therapy (IMRT)

Conference Medical Physics · January 1, 2008 Purpose: The IMRT treatment planning optimization process typically follows one, somewhat arbitrary, path, based on the manner in which the planner changes the optimization constraints/weights during planning. Thus, the planner usually never fully understa ... Full text Cite

SU‐GG‐J‐81: Efficacy of Patient Setup Correction Procedure in Prostate Radiotherapy

Conference Medical Physics · January 1, 2008 Purpose: Using an on‐board cone‐beam CT (CBCT) based statistical margin model to determine whether a prostate center‐of‐mass (COM) based translation correction procedure can significantly reduce the CTV‐to‐PTV margin required for prostate patients who were ... Full text Cite

SU‐GG‐I‐52: Conversion of On‐Board Digital TomoSynthesis (DTS) to HU Values

Conference Medical Physics · January 1, 2008 Purpose: To investigate a method to convert the pixel values of DTS images to HU values with reference HU values from CT images. Method and Materials: This study included CT and DTS images of two phantoms (Catphan and a chest phantom) and three patients (p ... Full text Cite

SU‐GG‐J‐119: Localization Accuracy of Target Verification System Using Digitial Tomosynthesis (DTS)

Conference Medical Physics · January 1, 2008 Purposes: A research platform was developed for target verification using digital tomosynthesis (DTS). To verify its accuracy, a phantom study was conducted and several clinical cases were investigated. Method and Materials: customer‐developed reconstructi ... Full text Cite

SU‐GG‐I‐53: The Impact of Scan Angles On the Visibility of Anatomy in On‐Board Digital Tomosynthesis (DTS) Images for Head and Neck Cancer Patients: A Single‐Observer Study

Conference Medical Physics · January 1, 2008 Purpose: To assess the impact of scan angles on the visibility of anatomy in on‐board digital tomosynthesis (DTS) images as a means to optimize this technique. Method and Materials: Head and neck cancer patients undergoing intensity‐modulated radiotherapy ... Full text Cite

TU‐EE‐A3‐03: On‐Board Four‐Dimensional Digital Tomosynthesis (4D‐DTS): Optimization of Respiratory Motion Dependent Acquisition and Reconstruction Parameters

Conference Medical Physics · January 1, 2008 Purpose: Amplitude and period of respiratory motion vary among patients. For four‐dimensional digital tomosynthesis (4D‐DTS), the frequency of projection acquisition and the phase window must be optimized based on respiratory motion. The purpose of this st ... Full text Cite

TH‐D‐351‐02: A Novel Digital Tomosynthesis (DTS) Reconstruction Method Using Prior Information and a Deformation Model

Conference Medical Physics · January 1, 2008 Purpose: Digital Tomosynthesis (DTS) is a quasi‐3D imaging technique which reconstructs images from a limited angle of on‐board projections with significantly lower dose and shorter acquisition time than full cone‐beam CT (CBCT). However, DTS images recons ... Full text Cite

SU‐GG‐I‐47: A New Limited‐Angle CT Reconstruction Method Based On Total‐Variation Minimization

Conference Medical Physics · January 1, 2008 Purpose: To develop a new CT reconstruction algorithm based on Total‐Variation (TV) minimization. The new algorithm is specifically designed for limited angle reconstruction to alleviate volume information loss caused by incomplete projections. Method and ... Full text Cite

SU‐GG‐T‐53: Integrating An Online Adaptive IMRT Process to the Prostate IGRT

Conference Medical Physics · January 1, 2008 Purpose: To investigate the feasibility of a novel online IMRT re‐optimization process. This online process can be an integral part to the current prostate IGRT paradigm to augment the existing patient alignment techniques for cases with complex daily orga ... Full text Cite

SU‐GG‐T‐13: Fast Seed Localization On MR Images For Post‐Prostate Implant Dosimetry

Conference Medical Physics · January 1, 2008 Purpose: Accurate and reliable post‐prostate implant dosimetric analysis requires optimal identification of the seeds on CT and optimal description of soft tissues on MRI. We present a fast seed localization technique for MRI that is also robust from motio ... Full text Cite

SU‐GG‐T‐54: On‐Line Adaptive IMRT for Prostate Cancer

Conference Medical Physics · January 1, 2008 Purpose: This study proposes a novel on‐line IGRT technique that can modify the original IMRT plan to match with the “anatomy‐of‐the‐day” within few minutes. The performance of this technique is compared with current on‐line IGRT strategies using bone/soft ... Full text Cite

SU‐GG‐J‐47: Clinical Implementation of An Integrated System for Image‐Guided Radiation Therapy (IGRT) and Adaptive Radiation Therapy (ART)

Conference Medical Physics · January 1, 2008 Purpose: It is critical that image‐guided radiation therapy (IGRT) and adaptive radiation therapy (ART) are performed with clearly defined goals without abusing the technologies. This study illustrates the current integrated system that provides efficient ... Full text Cite

SU‐GG‐T‐538: Dosimetric Effect of Energy Spread of Proton Beams

Conference Medical Physics · January 1, 2008 Purpose: To investigate how proton beam energy spreads dosimetrically affect proton plans. Method and Materials: Scanning proton beams were simulated using the Monte Carlo method. A computer program was developed to calculate the weights to produce the SOB ... Full text Cite

SU‐GG‐T‐255: Experimental Verification of Lung Tumor Dose with Radiochromic Film

Conference Medical Physics · January 1, 2008 Purpose: To assess the absorbed doses in and around lung tumor by performing radiochromic film measurements. Method and Materials: A phantom was made to have a water equivalent central core, a low‐density middle layer and a water equivalent outer layer to ... Full text Cite

SU‐GG‐J‐183: The Use of Video Feedback for the Improvement of Respiratory Gating Radiation Treatments

Conference Medical Physics · January 1, 2008 Purpose: Breath‐hold respiratory gating is currently being used to improve the quality of radiotherapy, especially for sites subject to internal motion. One technical challenge that exists is patient regulation of respiration. Typically, the radiation ther ... Full text Cite

MO‐D‐AUD C‐01: Targeting Using Surrogates

Conference Medical Physics · January 1, 2008 While technology for image guided radiotherapy (IGRT) has advanced dramatically over the past few years, the basic fact remains that the actual treated target remains poorly or not at all visible using most in‐room imaging technologies. As a result, target ... Full text Cite

Evaluation of Image Enhancement Method on Target Registration Using Cone Beam CT in Radiation Therapy.

Journal Article Clin Med Oncol · 2008 Featured Publication An intensity based six-degree image registration algorithm between cone-beam CT (CBCT) and planning CT has been developed for image-guided radiation therapy (IGRT). CT images of an anthropomorphic chest phantom were acquired using conventional CT scanner a ... Full text Link to item Cite

Use of the BrainLAB ExacTrac X-Ray 6D system in image-guided radiotherapy.

Journal Article Med Dosim · 2008 Featured Publication The ExacTrac X-Ray 6D image-guided radiotherapy (IGRT) system will be described and its performance evaluated. The system is mainly an integration of 2 subsystems: (1) an infrared (IR)-based optical positioning system (ExacTrac) and (2) a radiographic kV x ... Full text Link to item Cite

Comparison of radiation doses between cone beam CT and multi detector CT: TLD measurements.

Journal Article Radiat Prot Dosimetry · 2008 Featured Publication In recent years, wide beam computed tomography (CT) technique has become standard in radiation oncology whereas there is little information about radiation dose assessments for the technique. A point dose measurement method was employed to assess the radia ... Full text Link to item Cite

A phantom study on target localization accuracy using cone-beam computed tomography.

Journal Article Clin Med Oncol · 2008 Featured Publication The purpose of this study is to evaluate the 3-dimensional target localization accuracy of cone-beam computed tomography (CBCT) using an on-board imager (OBI). An anthropomorphic pelvis phantom was used to simulate a range of offsets in the three translati ... Full text Link to item Cite

Response to comments by Dr. Luijik and Dr. Schippers

Journal Article Medical Physics · January 1, 2008 Featured Publication Full text Cite

Evaluation of an electron Monte Carlo dose calculation algorithm for electron beams

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2008 Featured Publication The electron Monte Carlo (eMC) dose calculation algorithm of the Eclipse treatment planning system is based heavily upon Monte Carlo simulation of the linac head and modeling of the linac beam characteristics with minimal measurement of beam data. Commissi ... Full text Cite

An on-line adaptive radiation therapy system for intensity modulated radiation therapy: An application of multi-objective optimization

Journal Article Journal of Industrial and Management Optimization · January 1, 2008 Featured Publication Radiation therapy (RT) is a non-invasive and highly ekective treatment option for Prostate cancer. The goal is to deliver the prescription dose to the tumor (prostate) while minimizing the damages to the surrounding healthy organs namely bladder, rectum, a ... Full text Cite

Application of distance transformation on parameter optimization of inverse planning in intensity-modulated radiation therapy

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2008 Featured Publication In inverse planning for intensity-modulated radiation therapy (IMRT), the dose specification and related weighting factor of an objective function for involved organs is usually predefined by a single value and then iteratively optimized, subject to a set ... Full text Cite

Investigation of the location effect of external markers in respiratory-gated radiotherapy

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2008 Featured Publication In 7 lung and breast cancer patients, we investigated the location effect of external markers on the correlation between the motions of external markers and of an internal target under various breathing patterns. Our department developed a tumor tracking s ... Full text Cite

Clinical assessment and characterization of a dual tube kilovoltage X-ray localization system in the radiotherapy treatment room

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2008 Featured Publication Although flat-panel kilovoltage X-ray imaging devices have been well tested for clinical use in diagnostic radiology, their use as a part of an image-guided radiation therapy (IGRT) system in a treatment room is new and requires systematic assessment. We u ... Full text Cite

The impact of advanced technologies on treatment deviations in radiation treatment delivery.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2007 Featured Publication PURPOSE: To assess the impact of new technologies on deviation rates in radiation therapy (RT). METHODS AND MATERIALS: Treatment delivery deviations in RT were prospectively monitored during a time of technology upgrade. In January 2003, our department had ... Full text Link to item Cite

Cone-beam CT localization of internal target volumes for stereotactic body radiotherapy of lung lesions.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2007 Featured Publication PURPOSE: In this study, we investigate a technique of matching internal target volumes (ITVs) in four-dimensional (4D) simulation computed tomography (CT) to the composite target volume in free-breathing on-board cone-beam (CB) CT. The technique is illustr ... Full text Link to item Cite

Onboard SPECT for Biological Target Localization

Conference International Journal of Radiation Oncology*Biology*Physics · November 2007 Full text Cite

Investigation of a Support Vector Model to Predict Lung Radiotherapy (RT) Induced Pneumonitis (RP)

Conference International Journal of Radiation Oncology*Biology*Physics · November 2007 Full text Cite

Optimal Beam Selection to Enhance SPECT-Guided Reduction of IMRT Dose to Functioning Lung

Conference International Journal of Radiation Oncology*Biology*Physics · November 2007 Full text Cite

The Effect of Scan Angle on Target Localization Accuracy Using Digital Tomosynthesis

Conference International Journal of Radiation Oncology*Biology*Physics · November 2007 Full text Cite

Impact of Advanced Technologies on the Rate of Deviations in Radiation Treatment Delivery

Conference International Journal of Radiation Oncology*Biology*Physics · November 2007 Full text Cite

Implementation of Digital Tomosynthesis for On-Board Target Localization of Radiotherapy

Conference International Journal of Radiation Oncology*Biology*Physics · November 2007 Full text Cite

On-board patient positioning for head-and-neck IMRT: comparing digital tomosynthesis to kilovoltage radiography and cone-beam computed tomography.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2007 Featured Publication PURPOSE: High-precision intensity-modulated radiotherapy demands high patient positioning accuracy. On-board digital tomosynthesis (DTS) provides three-dimensional (3D) image guidance for daily positioning with a lower imaging dose, faster acquisition, and ... Full text Link to item Cite

Investigation of the support vector machine algorithm to predict lung radiation-induced pneumonitis.

Journal Article Med Phys · October 2007 Featured Publication The purpose of this study is to build and test a support vector machine (SVM) model to predict for the occurrence of lung radiation-induced Grade 2+ pneumonitis. SVM is a sophisticated statistical technique capable of separating the two categories of patie ... Full text Link to item Cite

Accelerating reconstruction of reference digital tomosynthesis using graphics hardware.

Journal Article Med Phys · October 2007 Featured Publication The successful implementation of digital tomosynthesis (DTS) for on-board image guided radiation therapy (IGRT) requires fast DTS image reconstruction. Both target and reference DTS image sets are required to support an image registration application for I ... Full text Link to item Cite

The management of imaging dose during image-guided radiotherapy: report of the AAPM Task Group 75.

Journal Article Med Phys · October 2007 Featured Publication Radiographic image guidance has emerged as the new paradigm for patient positioning, target localization, and external beam alignment in radiotherapy. Although widely varied in modality and method, all radiographic guidance techniques have one thing in com ... Full text Link to item Cite

Minimizing image noise in on-board CT reconstruction using both kilovoltage and megavoltage beam projections.

Journal Article Med Phys · September 2007 Featured Publication We studied a recently proposed aggregated CT reconstruction technique which combines the complementary advantages of kilovoltage (kV) and megavoltage (MV) x-ray imaging. Various phantoms were imaged to study the effects of beam orientations and geometry of ... Full text Link to item Cite

A neural network model to predict lung radiation-induced pneumonitis.

Journal Article Med Phys · September 2007 Featured Publication A feed-forward neural network was investigated to predict the occurrence of lung radiation-induced Grade 2+ pneumonitis. The database consisted of 235 patients with lung cancer treated using radiotherapy, of whom 34 were diagnosed with Grade 2+ pneumonitis ... Full text Link to item Cite

Evaluation of three types of reference image data for external beam radiotherapy target localization using digital tomosynthesis (DTS).

Journal Article Med Phys · August 2007 Featured Publication Digital tomosynthesis (DTS) is a fast, low-dose three-dimensional (3D) imaging approach which yields slice images with excellent in-plane resolution, though low plane-to-plane resolution. A stack of DTS slices can be reconstructed from a single limited-ang ... Full text Link to item Cite

Comparison of similarity measures for rigid-body CT/Dual X-ray image registrations.

Journal Article Technol Cancer Res Treat · August 2007 Featured Publication A set of experiments were conducted to evaluate six similarity measures for intensity-based rigid-body 3D/2D image registration. Similarity measure is an index that measures the similarity between a digitally reconstructed radiograph (DRR) and an x-ray pla ... Full text Link to item Cite

Predicting lung radiotherapy-induced pneumonitis using a model combining parametric Lyman probit with nonparametric decision trees.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2007 Featured Publication PURPOSE: To develop and test a model to predict for lung radiation-induced Grade 2+ pneumonitis. METHODS AND MATERIALS: The model was built from a database of 234 lung cancer patients treated with radiotherapy (RT), of whom 43 were diagnosed with pneumonit ... Full text Link to item Cite

Self-consistent tumor control probability and normal tissue complication probability models based on generalized EUDa).

Journal Article Med Phys · July 2007 Featured Publication Traditional methods to compute the tumor control probability (TCP) or normal tissue complication probability (NTCP) typically require a heterogeneous radiation dose distribution to be converted into a simple uniform dose distribution with an equivalent bio ... Full text Link to item Cite

Application of circumferencial myocardial function maps of tissue Doppler in patients with acute myocardial infarction

Journal Article Chinese Journal of Medical Imaging Technology · July 1, 2007 Featured Publication Objective: A circumferencial functional map (CFM) of tissue Doppler imaging (TDI) was applied in patients with coronary artery disease (CAD) and the accuracy of CFM in assessment of ischemic region in patients with acute myocardial infarction (AMI) was eva ... Cite

A model for optimizing adenoviral delivery in human cancer gene therapy trials.

Journal Article Hum Gene Ther · June 2007 Featured Publication Optimization of adenoviral delivery to the target volume is required for adenovirus-mediated cancer gene therapy to reach its maximal potential. The purpose of these studies was to develop a model of gene expression to improve adenovirus-mediated cancer ge ... Full text Link to item Cite

Reduction of organ motion by combined cardiac gating and respiratory gating.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2007 Featured Publication PURPOSE: To investigate whether the effect of organ motion can be further reduced with the application of a cardiac gating technique, together with respiratory gating. METHODS AND MATERIALS: Axial and coronal images through the heart and liver were continu ... Full text Link to item Cite

Evaluation of an artificial intelligence guided inverse planning system: clinical case study.

Journal Article Radiother Oncol · April 2007 Featured Publication PURPOSE: An artificial intelligence (AI) guided method for parameter adjustment of inverse planning was implemented on a commercial inverse treatment planning system. For evaluation purpose, four typical clinical cases were tested and the results from both ... Full text Link to item Cite

SU‐FF‐T‐148: Developing a Convenient and Effective IMRT QA Procedure Using MLC Dynalog Files

Conference Medical Physics · January 1, 2007 Purpose: To develop a convenient and effective patient‐specific IMRT quality assurance (QA) procedure utilizing MLC dynalog files. Method and Materials: IMRT plans are delivered with multi‐leaf collimators (MLC). The complexity of MLC motion and patterns m ... Full text Cite

SU‐FF‐T‐246: Implementation of Helical CT Source in DOSXYZnrc/EGSnrc Monte Carlo Code

Conference Medical Physics · January 1, 2007 Purpose: To implement and verify a new source type — phase‐space source in helical mode in DOSXYZnrc/EGSnrc Monte Carlo (MC) code. Method and Materials: To implement a new source type — “phase space source in helical mode” in DOSXYZnrc/EGSnrc, we modified ... Full text Cite

SU‐FF‐I‐37: An Adaptive Simultaneous Algebraic Reconstruction Technique

Journal Article Medical Physics · January 1, 2007 Purpose: To improve the computational efficiency of Algebraic Reconstruction Technique (ART), and suppress the “stripping” artifacts due to ART like ray‐by‐ray update, especially in cone‐beam reconstruction. Method and Materials: Inspired by Adaptive ART ( ... Full text Cite

SU‐EE‐A3‐06: Onboard SPECT: Functional‐Image‐Based Target Localization

Journal Article Medical Physics · January 1, 2007 Purpose: To investigate clinical feasibility for functional‐image‐based target localization via onboard single photon emission computed tomography (onboard SPECT). Specifically, to understand lesion visibility and signal‐to‐noise ratio (SNR) of onboard SPE ... Full text Cite

TH‐D‐M100E‐07: Determining the Geometric and Dosimetric Accuracy of MRI Based IMRT Treatment Plan for Patients with Prostate, Brain, and Head and Neck Cancers

Journal Article Medical Physics · January 1, 2007 Purpose: To determine the geometric and dosimetric accuracy of MRI‐based IMRT treatment plan for patients with prostate, brain, and head and neck cancers. Methods and Material: CT simulation images were obtained for prostate, brain and head and neck cancer ... Full text Cite

MO‐D‐M100F‐01: Emerging Techniques Using Digital Tomosynthesis

Journal Article Medical Physics · January 1, 2007 In‐room radiolographic imaging systems is being rapidly implemented in routine clinical operations for target localization. A typical system consists of a kV x‐ray source and an amorphous‐silicon flat panel detector mounted orthogonally to the MV‐beam axis ... Full text Cite

SU‐FF‐T‐419: Time‐Delay Measurement of Phase Gated Treatment with a Varian Real‐Time Position Management System Using Computed Radiography

Journal Article Medical Physics · January 1, 2007 Purpose: Respiratory gating systems have been developed to reduce treatment uncertainty caused by organ motions related to respiration. The time‐delay between when the gating signal is triggered and when the beam is turned on may affect the actual radiatio ... Full text Cite

MO‐SAMS‐AUD‐01: Daily Localization — I: Kilovolt Imaging

Journal Article Medical Physics · January 1, 2007 As high‐precision 3‐D conformal radiation therapy and intensity‐modulated radiation therapy have become standard practice, radiographic imaging using kilovoltage (kV) x‐ray sources has been rapidly implemented for in‐room target localization and patient po ... Full text Cite

Advanced radiation therapy technologies in the treatment of rectal and anal cancer: intensity-modulated photon therapy and proton therapy.

Journal Article Clin Colorectal Cancer · January 2007 Featured Publication Intensity-modulated photon radiation therapy (RT; IMRT) and proton therapy are advanced radiation technologies that permit improved conformation of radiation dose to target structures while limiting irradiation of surrounding normal tissues. Application of ... Full text Link to item Cite

SU‐FF‐J‐105: Predicting Late Skin Effects Using Digital Infrared Imaging for Breast Cancer Patients Treated with Radiation

Conference Medical Physics · January 1, 2007 Purpose: Establish a methodology based on digital infrared imaging (DII) to predict skin reaction after breast irradiation using the Skin Radiosensitivity Index (SRI) derived from early skin temperature changes. Method and Materials: Five breast cancer pat ... Full text Cite

SU‐FF‐J‐58: Clinical Evaluation Using Digital Tomosynthesis for Positioning Verification of Breath‐Hold Liver Treatment

Conference Medical Physics · January 1, 2007 Purpose: To demonstrate clinical feasibility of generating digital tomosynthesis (DTS) in a single breath‐hold (BH) period compared to multiple BH periods for CBCT acquisition and to examine on‐board BH‐DTS as an efficient alternative to BH‐CBCT for target ... Full text Cite

SU‐FF‐J‐48: Three‐Dimensional MRI and Cone‐Beam CT Matching for Localization of Prostate Cancer Treatment

Conference Medical Physics · January 1, 2007 PURPOSES: There is a growing interest using MRI only for prostate cancer treatment planning. This study is aimed to investigate clinical feasibility of matching 3D planning MRI to on‐board cone‐beam CT (CBCT) images for target localization. Materials and M ... Full text Cite

On-line adaptive planning system for prostate IMRT treatment

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · January 1, 2007 Link to item Cite

SU‐FF‐T‐252: Improvement of Localization Accuracy by Using 3D Cone Beam CT for Stereotactic Body Radiation Therapy of Liver, Lung and Spine Lesions

Conference Medical Physics · January 1, 2007 Purpose: To compare treatment isocenter placement based on OBI 2D kV imaging and OBI 3D‐CBCT imaging for patients undergoing SBRT, and compare the CBCT based isocenter shifts among liver, lung and spine lesions. Material and Methods: 119 SBRT fractions wer ... Full text Cite

Improved target localization with 3D cone beam CT On-Board Imaging in stereotactic body radiation therapy

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · 2007 Cite

SU‐FF‐J‐54: A Hybrid Multiresolution Method for Automatic Registration Between Reference and On Board Digital Tomosynthesis

Conference Medical Physics · January 1, 2007 Purpose: Automatic registration between reference and on‐board digital tomosynthesis (DTS) is a critical step for target localization using DTS. We previously developed an approximate method for automatic registration between reference and on‐board DTS, in ... Full text Cite

SU‐FF‐I‐39: Development of Clinical Application Platform Using Digital Tomosynthesis for Target Localization

Conference Medical Physics · January 1, 2007 Purpose: To develop a workstation for clinical application of digital tomosynthesis (DTS) for real‐time target localization. Specifically, to accelerate the reconstruction both digitally‐reconstructed radiograph (DRR) and DTS using ultra‐fast interpolation ... Full text Cite

TH‐D‐M100F‐01: An Evaluation of Noise in Radiotracer Emission Imaging Using Flat‐Panel Detectors

Conference Medical Physics · January 1, 2007 Purpose: Single Photon Emission Computed Tomography (SPECT) onboard radiation therapy machines could enable the use of functional and molecular imaging in guiding the therapy beam and in monitoring disease. Costs and spatial constraints of onboard SPECT mi ... Full text Cite

SU‐FF‐T‐172: Dosimetric Comparison of MapCheck with Monte Carlo Simulations

Conference Medical Physics · January 1, 2007 Purpose: This study is to verify IMRT QA MapCheck measurement using Monte Carlo simulations. Method and Materials: MapCheck (Sun Nuclear) contains 445 silicon diode detectors arranged in a 22×22‐cm2 area, of which 221 are located in the 10×10 cm2 center. T ... Full text Cite

SU‐FF‐T‐326: On the Use of Ice as a Water‐Equivalent Solid Medium for Brachytherapy Dosimetry Measurement

Conference Medical Physics · January 1, 2007 Purpose: It is well‐known that fluctuation in chemical compositions can lead to significant errors in the dosimetry of low‐energy brachytherapy sources using the traditional “water‐equivalent” solid phantoms. The aim of this work was to investigate the fea ... Full text Cite

SU‐FF‐J‐24: Toward Real‐Time Tracking of HDR Source Position Using Emission Imaging with a Collimator and Flat‐Panel Detector

Conference Medical Physics · January 1, 2007 Purpose: High dose rate (HDR) brachytherapy delivers rapidly a large, highly spatially varying dose. Consequently, precise quality assurance of source location and dwell time is important. Here, we propose that, with no additional radiation exposure to the ... Full text Cite

SU‐FF‐T‐438: Using Diode Dosimeters to Characterize Dose in the Buildup Region of High‐Energy Photon Beams

Conference Medical Physics · January 1, 2007 Purpose: For external photon beams, the depth dependence of the stopping power ratio between air and water in the buildup region is difficult for accurate quantitative characterization. Qualitatively the depth dependence increases as the photon energy incr ... Full text Cite

SU‐FF‐T‐14: A High MU Efficiency Dynamic MLC Leaf Sequencing Algorithm

Conference Medical Physics · January 1, 2007 Purpose: MU efficiency is a major figure of merit for dMLC leaf sequencing. However, leaf sequencing is often generated with focus on other constraints and the MU efficiency is taken as a byproduct. This work is to develop a new dMLC leaf sequencing algori ... Full text Cite

TU‐FF‐A3‐05: Real‐Time Lung Tumor Motion Prediction Using Neural Network Based Models Constructed From Unsorted Cine CT Images

Conference Medical Physics · January 1, 2007 Purpose: To develop neural network based models for predicting respiratory induced tumor motion from gating signals and unsorted cine CT images. The ability of the models to predict target motion given real‐time surrogate marker motion was verified using a ... Full text Cite

TH‐D‐AUD‐07: The Impact of SBRT Treatment Techniques On Dose Delivery in Presence of Organ Motion and Deformation

Conference Medical Physics · January 1, 2007 Purpose: The impact of organ motion and deformation has been studied for conventional radiation therapy. The cumulative dose is usually a blurred version of the static plan after motion‐induced hot and cold spots average out over a large number of fraction ... Full text Cite

TH‐E‐M100F‐07: Amplitude Gated Breath‐Hold Treatment for Upper Abdominal Lesions with On Board Imaging Guidance

Conference Medical Physics · January 1, 2007 Purpose: To apply on‐boardmdash;image (OBI) guided amplitude gating for breath‐hold treatment and to assess treatment margin adequacy by analyzing the isocenter placement based on orthogonal 2D kV radiographs and 3D cone‐beam CT (CBCT) acquired under ampli ... Full text Cite

SU‐DD‐A3‐04: On‐Line Re‐Optimization of Prostate IMRT Plans for Image Guided Adaptive Radiation Therapy

Conference Medical Physics · January 1, 2007 Purpose: This study proposes a novel on‐line adaptive planning technique for the prostate treatment by directly re‐optimizing the IMRT plan based on both the “anatomy‐of‐the‐day” and the original plan information. Method & Materials: Using a commercial tre ... Full text Cite

WE‐E‐M100F‐01: 3D Interfraction Position Verification for Patients Undergoing Partial Breast Irradiation: Comparing Digital Tomosynthesis to Cone‐Beam CT

Conference Medical Physics · January 1, 2007 Purpose: This clinical study evaluates digital tomosynthesis (DTS) technology for daily imaging guidance for partial breast irradiation (PBI) and compares its positioning accuracy to the 3D CBCT technique. Compared to CBCT, DTS offers lower imaging dose an ... Full text Cite

TU‐EE‐A3‐03: Performing Concurrent Kilovoltage Imaging While Delivering Megavoltage Treatment Beams

Conference Medical Physics · January 1, 2007 Purpose: To investigate the clinical feasibility of performing concurrent kilovoltage (kV) x‐ray imaging while the patient at the treatment position was irradiated by megavoltage (MV) beams. Method and Materials: Anatomical visibility and contrast details ... Full text Cite

SU‐FF‐J‐57: A Phantom Study On the 3‐D Target Localization Accuracy Using CBCT of An On‐Board Imager

Conference Medical Physics · January 1, 2007 Purpose: To evaluate the three‐dimensional target localization accuracy using CBCT of an On‐Board Imager (OBI) system by determining the detection error and residual error associated with image registration and patient repositioning. Method and Materials: ... Full text Cite

SU‐FF‐T‐377: Self‐Learning AI Technique for Parameter Optimization of IMRT Treatment Planning

Conference Medical Physics · January 1, 2007 Purpose: The conventional application of Fuzzy Inference System (FIS) on parameter optimization of IMRT treatment planning requires that the FIS model (membership function, inference rules) to be predetermined in an intuitive way based on prior planner's k ... Full text Cite

SU‐FF‐J‐68: Dosimetric Comparison of Patient‐Specific Margins Vs. Uniform Margins for Prostate IMRT Treatments

Conference Medical Physics · January 1, 2007 Purpose: To evaluate the dosimetric improvement of IMRT treatment plans generated with patient‐specific margins compared to uniform margins for prostate cancer patients. Methods and Materials: For 13 prostate cancer patients who underwent IMRT treatment, d ... Full text Cite

A quality assurance program for the on-board imager®

Conference IFMBE Proceedings · January 1, 2007 Purpose: To develop a comprehensive quality assurance (QA) program for the On-Board Imager (OBI) used for patient positioning verification and to present the results of QA tests over extended periods from multiple institutions. Radiographic and cone-beam c ... Full text Cite

SU‐FF‐T‐88: Augmenting Lyman NTCP by Adding the Influence of Non‐Dose Variables Via Decision Trees: Application to Lung Radiation‐Pneumonitis Prediction

Conference Medical Physics · January 1, 2007 Purpose: Develop a model that augments the dose‐based parametric Lyman NTCP formulation using non‐parametric decision trees that can additionally account for the influence of non‐dose variables. Apply and test the model to predict Grade 2+ lung radiotherap ... Full text Cite

SU‐FF‐T‐300: Monte Carlo Benchmark for Radiation Dose Assessment in Varian On‐Board Imager

Conference Medical Physics · January 1, 2007 Purpose: To evaluate radiation dose in kV cone‐beam computed tomography (CBCT) and to benchmark Monte Carlo (MC) simulations in the PMMA CT phantoms Method and Materials: Using an On‐Board Imager (Varian Medical Systems), we measured absorbed doses to the ... Full text Cite

TH‐E‐M100E‐03: Optimizing the Methodology for Incorporating SPECT‐Guidance to Reduce Intensity Modulated Radiation Therapy (IMRT) Dose to Functioning Lung

Conference Medical Physics · January 1, 2007 Purpose: Single photon emission computed tomography (SPECT) provides a spatial distribution map of lung perfusion. Previously, an algorithmic methodology was developed using IMRT and SPECT guidance to deliberately divert dose away from higher functioning ( ... Full text Cite

Feasibility of cone-beam CT based treatment planning

Conference IFMBE Proceedings · January 1, 2007 Purpose: This study investigates feasibility of CBCT-based treatment planning. Methods and materials: Hounsfield unit (HU) values and profiles of phantoms and patients in CBCT images were compared to those in CT images. CBCT-based treatment plans for the p ... Full text Cite

SU‐FF‐J‐81: Estimation of Dose Variations During Prostate Radiation Treatment Due to Elastic Deformations of Soft Tissues

Conference Medical Physics · January 1, 2007 Objective: The true dose distribution is subject to change due to organ shifts and also deformations. The goal of this work is to estimate the effect of the elastic organ deformations on the dose distribution for the average prostate IMRT treatment. Method ... Full text Cite

Dosimetric feasibility of cone-beam CT-based treatment planning compared to CT-based treatment planning.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2006 Featured Publication PURPOSE: Cone-beam computed tomography (CBCT) images are currently used for positioning verification. However, it is yet unknown whether CBCT could be used in dose calculation for replanning in adaptive radiation therapy. This study investigates the dosime ... Full text Link to item Cite

A methodology for using SPECT to reduce intensity-modulated radiation therapy (IMRT) dose to functioning lung.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2006 Featured Publication PURPOSE: Single photon emission computed tomography (SPECT) provides a map of the spatial distribution of lung perfusion. Thus, SPECT guidance can be used to divert dose away from higher-functioning lung, potentially reducing lung toxicity. We present a me ... Full text Link to item Cite

A quality assurance program for the on-board imager®.

Journal Article Med Phys · November 2006 Featured Publication To develop a quality assurance (QA) program for the On-Board Imager (OBI) system and to summarize the results of these QA tests over extended periods from multiple institutions. Both the radiographic and cone-beam computed tomography (CBCT) mode of operati ... Full text Link to item Cite

The correlation evaluation of a tumor tracking system using multiple external markers.

Journal Article Med Phys · November 2006 Featured Publication The purpose of this study is to evaluate the correlations between external markers and internal targets for radiation therapy of lung cancer patients. Using an infrared camera system coupled with a clinical simulator, the simultaneous motions of multiple e ... Full text Link to item Cite

2824

Conference International Journal of Radiation Oncology*Biology*Physics · November 2006 Full text Cite

2882

Conference International Journal of Radiation Oncology*Biology*Physics · November 2006 Full text Cite

Digital tomosynthesis with an on-board kilovoltage imaging device.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2006 Featured Publication PURPOSE: To generate on-board digital tomosynthesis (DTS) and reference DTS images for three-dimensional image-guided radiation therapy (IGRT) as an alternative to conventional portal imaging or on-board cone-beam computed tomography (CBCT). METHODS AND MA ... Full text Link to item Cite

Postoperative radiosurgery for malignant spinal tumors.

Journal Article Neurosurgery · May 2006 Featured Publication OBJECTIVE: Although, as a primary therapy, radiosurgery for spinal tumors is becoming more common in clinical practice and is associated with encouraging clinical results, we wanted to evaluate outcomes after radiosurgery in a series of postoperative patie ... Full text Link to item Cite

Physics and imaging for targeting of oligometastases.

Journal Article Semin Radiat Oncol · April 2006 Featured Publication Oligometastases refer to metastases that are limited in number and location and are amenable to regional treatment. The majority of these metastases appear in the brain, lung, liver, and bone. Although the focus of interest in the past within radiation onc ... Full text Link to item Cite

A technique of using gated-CT images to determine internal target volume (ITV) for fractionated stereotactic lung radiotherapy.

Journal Article Radiother Oncol · February 2006 Featured Publication BACKGROUND AND PURPOSE: To develop and evaluate a technique and procedure of using gated-CT images in combination with PET image to determine the internal target volume (ITV), which could reduce the planning target volume (PTV) with adequate target coverag ... Full text Link to item Cite

Adaptive prediction of internal target motion using external marker motion: a technical study.

Journal Article Phys Med Biol · January 7, 2006 Featured Publication An adaptive prediction approach was developed to infer internal target position by external marker positions. First, a prediction model (or adaptive neural network) is developed to infer target position from its former positions. For both internal target a ... Full text Link to item Cite

TH‐C‐330A‐05: Analysis of the Point Spread Function of Isocentric Digital Tomosynthesis (DTS)

Conference Medical Physics · January 1, 2006 Purpose: This project presents an analysis of the point spread function (PSF) of isocentric digital tomosynthesis (DTS). DTS is a limited angle 3‐ dimensional reconstruction from cone beam projections, with high resolution for excellent imaging of both bon ... Full text Cite

SU‐FF‐I‐19: A Study of Megavoltage Beam Tomosynthesis

Conference Medical Physics · January 1, 2006 Purpose: To study the impact of projection numbers on the quality of tomosynthesis images using megavoltage beams. Method and Materials: It has been shown that isocentric kilovoltage tomosynthesis images can be generated with no more than 50 degree scan an ... Full text Cite

SU‐FF‐T‐208: Efficient Selection of Beam Number and Orientations for Intensity Modulated Radiotherapy (IMRT) by Emulating An Ideal Dose Distribution

Conference Medical Physics · January 1, 2006 Purpose: Since radiotherapy treatments only utilize a limited number of beams, it is important that these beams be carefully selected to extract maximum benefit. Here we propose a novel, fast, scheme that selects beam number and orientations for IMRT with ... Full text Cite

WE‐E‐ValA‐03: Dosimetric Evaluation of Prostate IMRT Treatments Positioned Based On Cone‐Beam CT

Conference Medical Physics · January 1, 2006 Purpose: To evaluate the dosimetric consequence of 3D positioning verification for prostate IMRT treatment using CBCT. Method and Materials: Patients in this study were repositioned using 2D orthogonal radiographic images, taken prior to treatment to match ... Full text Cite

TH‐C‐ValB‐04: Evaluation of the Quality of 3D‐3D Mutual Information (MI) Shared Between Reference and On‐Board DTS Images

Conference Medical Physics · January 1, 2006 Purpose: Digital tomosynthesis (DTS) is a fast, low‐dose method for reconstructing 3‐D slices from 2‐D cone‐beam x‐ray projection data acquired with limited source angulation (e.g., 40°). We previously developed a method for reconstructing reference DTS (R ... Full text Cite

SU‐FF‐I‐09: Minimizing Scatter Artifact in Cone‐Beam CT Reconstruction Using Both Kilovoltage and Megavoltage Beams

Conference Medical Physics · January 1, 2006 Purpose: To study the effect of imaging orientations on image quality of aggregated conebeam CT and to develop a strategy to minimize scatter artifact. Method and Materials: Orthogonal kilovoltage (kV) and megavoltage (MV) beam projections were acquired an ... Full text Cite

Towards four dimensional (4D) dosimetry for radiation-therapy.

Journal Article J Phys Conf Ser · 2006 Featured Publication Full text Link to item Cite

SU‐DD‐A4‐01: Quantifying Skin Effects After Accelerated Partial Breast Irradiation Using Digital Infrared Imaging (DII): Preliminary Feasibility Data

Conference Medical Physics · January 1, 2006 Purpose: Accelerated partial‐breast irradiation (APBI) is an emerging radiation technique that challenges standard whole breast irradiation. The larger fraction sizes used in these hypofractionated schedules may increase the risk of late normal tissue effe ... Full text Cite

SU‐FF‐T‐66: A Technique for Cone‐Beam CT‐Guided Stereotactic Body Radiation Therapy

Conference Medical Physics · January 1, 2006 Purpose: To develop and assess a technique using cone‐beam CT (CBCT) to localize treatment targets for stereotactic body radiation therapy (SBRT). Material and Methods: Patients selected for SBRT had 3‐D or 4‐D CT simulation with immobilization. GTV, CTV, ... Full text Cite

SU‐FF‐T‐219: Evaluation of a Practical and Low Cost Gafchromic Film/flat‐Bed Scanner Combination for Planar Dosimetry

Conference Medical Physics · January 1, 2006 Purpose: To assess the accuracy and practicality of using GAFCHROMIC® EBT Film in combination with an Epson flat‐bed scanner for the verification of advanced treatment techniques in radiation therapy. EBT is a new type of Gafchromic film with high sensitiv ... Full text Cite

SU‐CC‐ValA‐01: Automatic Comparison Between Reference and On Board Digital Tomosynthesis for Target Localization

Conference Medical Physics · January 1, 2006 Purpose: Digital tomosynthesis (DTS) is a method for reconstructing 3D images from cone‐beam projection data acquired with limited angulation (e.g., 40°) of an x‐ray source, and is much faster and lower dose than full cone‐beam CT (CBCT). We previously dev ... Full text Cite

TU‐FF‐A3‐02: Preliminary Investigations Into Combined CT/SPECT Imaging Onboard Therapy Machines

Conference Medical Physics · January 1, 2006 Purpose: Functional and molecular (F&M) imaging onboard radiation therapy machines would allow for targeting of functional tumor volume, and avoiding of healthy tissue, by guiding and modifying radiation beams, in the treatment room, based on real‐time F&M ... Full text Cite

SU‐FF‐T‐263: Imaging with Brachytherapy Sources

Conference Medical Physics · January 1, 2006 Purpose: To demonstrate the concept of 2D projection and 3D volumetric imaging using brachytherapy treatment sources in patient prior to or during treatment. Method and Materials: As shown Figure 1, an Ir‐192 HDR catheter is placed at 15 cm depth (a reason ... Full text Cite

SU‐FF‐T‐221: Evaluation of An Electron Monte Carlo Dose Calculation Algorithm for Electron Beam Radiotherapy

Conference Medical Physics · January 1, 2006 Purpose: To systematically evaluate the electron Monte Carlo (eMC) dose calculation algorithm of the Eclipse treatment planning system and to identify factors that affect its calculation accuracy. Method and Materials: Percent depth dose (PDD) and profiles ... Full text Cite

SU‐FF‐T‐151: Conservation of Integrated Reference Air Kerma

Conference Medical Physics · January 1, 2006 Purpose: To demonstrate the conservation rule of the integrated reference air kerma (IRAK). Method and Materials: For a brachytherapy photon source whose radial dose functions is flat over the clinical distance range, the dose falls off with the inverse sq ... Full text Cite

SU‐FF‐J‐22: An Image Based Statistical Shape Model and Its Application in Radiotherapy Margin Design

Conference Medical Physics · January 1, 2006 Purpose: A novel imaging based model is proposed to describe the stochastic nature of the shape and location of a volume of interest (VOI). Based on the VOIs in sequential patient images, the model can predict the probability that a specific point will bel ... Full text Cite

SU‐FF‐I‐17: Reduction of Set‐Up Error Using Cone Beam‐CT in Patients Undergoing Partial Breast Irradiation

Conference Medical Physics · January 1, 2006 Purpose: Partial breast irradiation with multiple external beams requires accurate alignment of the target volume and treatment isocenter. On‐board plannar kV/MV imaging can verify set‐up based on boney landmarks. On‐board cone beam CT (CBCT) may provide a ... Full text Cite

SU‐EE‐A1‐04: Verifying Internal Target Volume Using Cone‐Beam CT for Stereotactic Body Radiotherapy Treatment

Conference Medical Physics · January 1, 2006 Purpose: The internal target volume (ITV) could be determined using 4D CT simulation images and be verified in the treatment room using on‐board cone‐beam CT (CBCT) since the CBCT projection images are acquired over approximately 10 breathing cycles. This ... Full text Cite

SU‐FF‐T‐432: Time‐Delay Measurement of a Varian Real‐Time Position Management System

Conference Medical Physics · January 1, 2006 Purpose: Respiratory gating systems have been developed to reduce treatment uncertainty caused by organ motions related to respiration. The time‐delay between when the gating signal is triggered and when the beam is turned on may affect the actual radiatio ... Full text Cite

SU‐FF‐J‐86: Intra‐ and Inter‐Breath‐Hold Position Variations for OBI Guided Amplitude Gating Treatment with Breath Hold

Conference Medical Physics · January 1, 2006 Purpose: We have applied OBI guidance together with a respiratory gating system to effectively control patient positioning for amplitude gating treatment with breath hold. The deep inspiration breath‐hold treatment has been proven effective in reducing the ... Full text Cite

MO‐A‐224C‐01: Daily Localization I: KV/CBCT

Conference Medical Physics · January 1, 2006 Daily target localization is a critical step to secure accurate delivery for 3‐D conformal radiation therapy and intensity‐modulated radiation therapy. One emerging technology using in‐room kilovoltage (kV) imaging has shown to be very promising for target ... Full text Cite

SU‐FF‐J‐16: A Tool for Off‐Line Review of 3D Target Verification and Localization with Cone‐Beam Computed Tomography

Conference Medical Physics · January 1, 2006 Purpose: To implement a clinical tool for off‐line review of Cone‐Beam Computed Tomography (CBCT) based 3D target verification and localization. Methods and Materials: An in‐house 3D target localization and verification tool is being developed to allow phy ... Full text Cite

SU‐FF‐J‐118: Respiration Phase‐Based Cone‐Beam Computed Tomography (CBCT) Reconstruction

Conference Medical Physics · January 1, 2006 Purpose: To develop a method to reconstruct CBCT data based on projection data acquired at a specific respiration phase. Methods and Materials: The original projection data were acquired using an on‐board imager (OBI) (Varian Medical Systems) over scanning ... Full text Cite

SU‐FF‐T‐124: Clinical Evaluation of the Performance of a Fuzzy Logic Guided Parameter Optimization for Inverse Treatment Planning

Conference Medical Physics · January 1, 2006 Purpose: To evaluate the effectiveness of a Fuzzy Logic guided parameter optimization method for inverse treatment planning, in comparison with the results achieved by routine trial‐and‐error method. Method and Materials: The optimization algorithm was dev ... Full text Cite

SU‐FF‐J‐96: Modeling Correlation Between External Surface Motion and Internal Organ Motion Based On 4DCT

Conference Medical Physics · January 1, 2006 Purpose: To develop a method for modeling the dynamic relationship between patient surface motion and internal target motion using 4DCT data. Then, to verify its capability to interpolate internal target motion with real‐time patient surface motion informa ... Full text Cite

SU‐FF‐T‐374: Quality Assurance of the On‐Board Imager and Cone‐Beam Computed Tomography Systems

Conference Medical Physics · January 1, 2006 Purpose: To develop a comprehensive quality assurance (QA) program for the On‐Board Imager (OBI) used for patient positioning verification and to present the results of QA tests over extended periods from multiple institutions. Radiographic and cone‐beam c ... Full text Cite

TH‐C‐224C‐09: Using SPECT‐Guidance to Reduce Intensity Modulated Radiation Therapy (IMRT) Dose to Functioning Lung

Conference Medical Physics · January 1, 2006 Purpose: Single photon emission computed tomography (SPECT) provides a map of the spatial distribution of lung perfusion. Thus, SPECT guidance can be used to deliberately divert dose away from higher functioning lung, thereby potentially reducing lung toxi ... Full text Cite

TU‐FF‐A2‐01: Feasibility of Cone‐Beam CT Based Treatment Planning

Conference Medical Physics · January 1, 2006 Purpose: To investigate the feasibility of cone‐beam computed tomography (CBCT)‐based treatment planning. Methods: HU of material disks in Catphan, HU profiles for homogeneous and inhomogeneous phantoms, and HU values in different tissue areas of brain, th ... Full text Cite

Improved Prediction of Radiation Pneumonitis using Multiple Additive Regression Trees

Conference International Journal of Radiation Oncology*Biology*Physics · October 2005 Full text Cite

Online Digital Tomosynthesis (DTS): A Novel Technique for Improving Target Localization in Radiation Therapy

Conference International Journal of Radiation Oncology*Biology*Physics · October 2005 Full text Cite

Extrapolating Organ Motion Margin for Radiation Fields from Sequential Patient Images

Conference International Journal of Radiation Oncology*Biology*Physics · October 2005 Full text Cite

Heart Dose Reduction for Radiation Treatments of Left-Sided Breast Cancer by Using 4D Simulation and 4D Verification

Conference International Journal of Radiation Oncology*Biology*Physics · October 2005 Full text Cite

A technique for on-board CT reconstruction using both kilovoltage and megavoltage beam projections for 3D treatment verification.

Journal Article Med Phys · September 2005 Featured Publication The technologies with kilovoltage (kV) and megavoltage (MV) imaging in the treatment room are now available for image-guided radiation therapy to improve patient setup and target localization accuracy. However, development of strategies to efficiently and ... Full text Link to item Cite

Time delay measurement for linac based treatment delivery in synchronized respiratory gating radiotherapy.

Journal Article Med Phys · May 2005 Featured Publication A time delay in a respiratory gating system could cause an unexpected phase mismatch for synchronized gating radiotherapy. This study presents a method of identifying and measuring the time delay in a gating system. Various port films were taken for a moti ... Full text Link to item Cite

Effects of x-ray and CT image enhancements on the robustness and accuracy of a rigid 3D/2D image registration.

Journal Article Med Phys · April 2005 Featured Publication A rigid body three-dimensional/two-dimensional (3D/2D) registration method has been implemented using mutual information, gradient ascent, and 3D texturemap-based digitally reconstructed radiographs. Nine combinations of commonly used x-ray and computed to ... Full text Link to item Cite

Dosimetric study using different leaf-width MLCs for treatment planning of dynamic conformal arcs and intensity-modulated radiosurgery.

Journal Article Med Phys · February 2005 Featured Publication This paper systematically studied the dosimetric difference between a 3 mm micro multileaf collimator (MLC), a 5 mm MLC, and a 10 mm MLC for stereotactic radiosurgery using the Brainscan treatment planning system. Thirty-four cases treated with the dynamic ... Full text Link to item Cite

WE‐D‐T‐6E‐02: A Clinical Planning Tool for Optimization of Intensity Modulated Radiotherapy Parameters

Journal Article Medical Physics · January 1, 2005 Purpose: To develop a clinical tool that incorporates novel strategies to optimize all involved parameters in IMRT treatment planning: (a) the number of beams, (b) beam orientations, and (c) fluence maps. Method and Materials: An IMRT planning tool was dev ... Full text Cite

SU‐FF‐T‐61: A Pseudo‐Tangential IMRT Technique for the Whole Large Left Breast Radiation Therapy Using Helios/Eclipse System

Journal Article Medical Physics · January 1, 2005 Purpose: A pseudo‐tangential IMRT (PT‐IMRT) technique was developed to achieve high dose uniformity for the whole large left breast (separations >24 cm and volumes > 1200cc) radiation therapy and to reduce the early and late skin and subcutaneous reactions ... Full text Cite

SU‐FF‐T‐190: Daily Quality Assurance (QA) Procedure of On‐Board Imager (OBI)

Journal Article Medical Physics · January 1, 2005 Purpose: Developed a daily QA procedure for checking; 1) the accuracy of the imager isocenter and 2) the auto couch motion accuracy of the On‐Board Imager (OBI) device developed by Varian. This QA procedure will assure that the imager isocenter matches the ... Full text Cite

SU‐FF‐T‐212: Quality Assurance (QA) Procedure of On‐Board Imager (OBI) for Portal Imaging

Journal Article Medical Physics · January 1, 2005 Purpose: On‐board imager (OBI) has been implemented to improve the in‐room patient positioning. It is therefore important to establish quality assurance (QA) procedure to ensure proper functionality and operational accuracy. This report presents monthly OB ... Full text Cite

SU‐FF‐J‐70: Respiratory Gated Radiation Therapy Directly Using Patient's Fluoroscopic Images Instead of External Or Internal Markers

Conference Medical Physics · January 1, 2005 Purpose: To develop a respiratory gated radiation therapy (RGRT) technique by directly matching the patient's anatomical structures acquired during the imaging cycles to that in a reference image. Method and Materials: Studies showed that the external mark ... Full text Cite

SU‐FF‐J‐30: Quantification of Normal Organ Motion Due to the Respiratory and Cardiac Cycles

Conference Medical Physics · January 1, 2005 Purpose: To quantify the degree of normal organ motion due to the respiratory and cardiac cycles. Better definition of such motion may be useful in defining field margins and in assessing the utility of gating technologies. Method and Materials: Four healt ... Full text Cite

SU‐FF‐J‐57: Digital Tomosynthesis for Verification of Radiation Therapy Positioning: Preliminary Results From a Kilovoltage On‐Board Imaging System

Conference Medical Physics · January 1, 2005 Purpose: This study introduces a new radiation therapy target localization technique using online digital tomosynthesis (DTS), a method for reconstructing 3‐D slices from 2‐D projection data acquired with limited source motion. By separating the visualizat ... Full text Cite

SU‐EE‐A4‐04: Compartment Modeling Analysis of Cu‐ATSM Dynamic PET Images

Conference Medical Physics · January 1, 2005 Purpose: Copper labeled diacetyl‐bis(N4‐methylthiosemicarbazone) (Cu‐ATSM) has been reported to selectively bind to hypoxic tumor cells. This makes Cu‐ATSM PET a promising modality to image tumor hypoxia. However, intravascular Cu‐ATSM that is not related ... Full text Cite

SU‐FF‐T‐186: Commissioning of Tissue Inhomogeneity Correction of Eclipse Radiation Treatment Planning System Using a Lung Phantom

Conference Medical Physics · January 1, 2005 Purpose: It has been noted that dosimetric difference due to tissue inhomogeneity is significant for a lung patient. If there is no tissue inhomogeneity correction (IC) made, the treatment plan could mislead treatment. Commercial radiation treatment planni ... Full text Cite

SU‐FF‐J‐80: Clinical Procedures for Daily Patient Setup Verification Using On‐Board Imager (OBI)

Conference Medical Physics · January 1, 2005 Purpose: The newly installed OBI system consists of a kilo‐voltage (KV) X‐ray source and a flat‐ panel detector mounted orthogonally to the megavoltage portal imager (MV) in Varian 21EX machine. These devices are linked to the OBI workstation which provide ... Full text Cite

Adaptive algebraic reconstruction technique.

Journal Article Med Phys · December 2004 Featured Publication Algebraic reconstruction techniques (ART) are iterative procedures for reconstructing objects from their projections. It is proven that ART can be computationally efficient by carefully arranging the order in which the collected data are accessed during th ... Full text Link to item Cite

Image-guided procedures for intensity-modulated spinal radiosurgery. Technical note.

Journal Article J Neurosurg · November 2004 Featured Publication Radiosurgery for brain tumors has been well established in the radiation oncology and neurosurgery fields. Radiosurgery of extracranial tumors such as those involving the spine is, however, still in the early stage because of difficulties in patient immobi ... Link to item Cite

A novel needle-based miniature x-ray generating system.

Journal Article Phys Med Biol · October 21, 2004 Featured Publication The basic concept, design and performance of a novel needle-based x-ray system for medical applications are reported. The main principle of the system is based on a two-stage production of x-rays. The system comprises a conventional x-ray tube with an Ag a ... Full text Link to item Cite

Novalis radiosurgery for metastatic spine tumors.

Journal Article Neurosurg Clin N Am · October 2004 Featured Publication It is logical to anticipate that the field of spinal radiosurgery will evolve in a fashion similar to that seen for intracranial radiosurgery. Given the frequency of various pathologic entities that affect the spine, including those that have proven to be ... Full text Link to item Cite

Image-guided radiosurgery of head and neck cancers.

Journal Article Otolaryngol Head Neck Surg · June 2004 Featured Publication OBJECTIVES: Radiosurgery precisely delivers a single high dose or a few fractionated doses of radiation to a localized tumor via the stereotactic approach. Some head and neck sites are suitable for radiosurgery since there is minimal or no organ motion. Th ... Full text Link to item Cite

A quantitative method for measuring gene expression magnitude and volume delivered by gene therapy vectors.

Journal Article Mol Ther · April 2004 Featured Publication This study describes a quantitative method to measure the magnitude and distribution of gene expression following local delivery of an adenoviral vector containing the human sodium iodide symporter (hNIS) reporter gene into the canine prostate. Following s ... Full text Link to item Cite

The evolving role of stereotactic radiosurgery and stereotactic radiation therapy for patients with spine tumors.

Journal Article J Neurooncol · 2004 Featured Publication Traditional management strategies for patients with spinal tumors have undergone considerable changes during the last 15 years. Significant improvements in digital imaging, computer processing, and treatment planning have provided the basis for the applica ... Full text Link to item Cite

A phantom study on the positioning accuracy of the Novalis Body system.

Journal Article Med Phys · December 2003 Featured Publication A phantom study was conducted to investigate inherent positioning accuracy of an image-guided patient positioning system-the Novalis Body system for three-dimensional (3-D) conformal radiotherapy. This positioning system consists of two infrared (IR) camer ... Full text Link to item Cite

AI-guided parameter optimization in inverse treatment planning.

Journal Article Phys Med Biol · November 7, 2003 Featured Publication An artificial intelligence (AI)-guided inverse planning system was developed to optimize the combination of parameters in the objective function for intensity-modulated radiation therapy (IMRT). In this system, the empirical knowledge of inverse planning w ... Full text Link to item Cite

Fuzzy logic guided inverse treatment planning.

Journal Article Med Phys · October 2003 Featured Publication A fuzzy logic technique was applied to optimize the weighting factors in the objective function of an inverse treatment planning system for intensity-modulated radiation therapy (IMRT). Based on this technique, the optimization of weighting factors is guid ... Full text Link to item Cite

GENIS: gene expression of sodium iodide symporter for noninvasive imaging of gene therapy vectors and quantification of gene expression in vivo.

Journal Article Mol Ther · September 2003 Featured Publication With the goal of optimizing adenovirus-mediated suicide gene therapy for prostate cancer, we have developed a method based on the human sodium iodide symporter (hNIS) that allows for noninvasive monitoring of adenoviral vectors and quantification of gene e ... Full text Link to item Cite

Point dose verification for intensity modulated radiosurgery using Clarkson's method.

Journal Article Med Phys · August 2003 Featured Publication In clinical radiation physics chart checking, the dose calculation results generated by computer treatment planning software are usually verified by an independent computerized monitor unit calculation routine, or by "hand calculation" using percent depth ... Full text Link to item Cite

Image-guided and intensity-modulated radiosurgery for patients with spinal metastasis.

Journal Article Cancer · April 15, 2003 Featured Publication BACKGROUND: Radiosurgery can deliver a single, large radiation dose to a localized tumor using a stereotactic approach and hence, requires accurate and precise delivery of radiation to the target. Of the extracranial organ targets, the spine is considered ... Full text Link to item Cite

A technique of intensity-modulated radiosurgery (IMRS) for spinal tumors.

Journal Article Med Phys · December 2002 Featured Publication This study is to demonstrate the feasibility of spinal radiosurgery using an image-guided intensity-modulated radiosurgical (IMRS) procedure. A dedicated Novalis shaped beam surgery unit equipped with a built-in micro-multileaf collimator (mMLC) with a sin ... Full text Link to item Cite

Radiosurgical treatment for Ewing's sarcoma of the lumbar spine: case report.

Journal Article Spine (Phila Pa 1976) · November 1, 2002 Featured Publication STUDY DESIGN: Case report. OBJECTIVES: The objective of this study was to document the long-term follow-up of a single case. SUMMARY OF BACKGROUND DATA: Radiosurgery is potentially a useful therapeutic option for spinal tumors. The authors present the unus ... Full text Link to item Cite

Accuracy of inhomogeneity correction in photon radiotherapy from CT scans with different settings.

Journal Article Phys Med Biol · September 7, 2002 Featured Publication We report an investigation on the accuracy of inhomogeneity correction in photon radiotherapy from CT scans with different settings. Specifically, the dosimetric differences from different CT scan parameters (kV, mAs) to phantoms and from different Hounsfi ... Full text Link to item Cite

Dosimetric characteristics of Novalis shaped beam surgery unit.

Journal Article Med Phys · August 2002 Featured Publication The dosimetric characteristics of a new dedicated radiosurgical treatment unit are systematically measured in terms of its percent depth dose, beam profile, and relative scatter factor. High-resolution diode detector, mini-ion-chamber detector, and convent ... Full text Link to item Cite

A three-dimensional deformable model for segmentation of human prostate from ultrasound images.

Journal Article Med Phys · October 2001 Featured Publication Segmentation of human prostate from ultrasound (US) images is a crucial step in radiation therapy, especially in real-time planning for US image-guided prostate seed implant. This step is critical to determine the radioactive seed placement and to ensure t ... Full text Link to item Cite

Extracranial radiosurgery: immobilizing liver motion in dogs using high-frequency jet ventilation and total intravenous anesthesia.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2001 Featured Publication PURPOSE: Extracranial radiosurgery requires control of organ motion. The purpose of this study is to quantitatively determine the extent of liver motion in anesthetized dogs with continuous i.v. propofol infusion with or without muscle relaxants and high-f ... Full text Link to item Cite

Adaptive portal CT reconstruction: a simulation study.

Journal Article Med Phys · October 2000 Featured Publication In radiotherapy, radiation treatment beams contain valuable information for patient setup verification. These beams may be used for portal CT reconstruction. However, direct use of the beam data for reconstruction may yield inadequate CT images simply beca ... Full text Link to item Cite

Optimization of inverse treatment planning using a fuzzy weight function.

Journal Article Med Phys · April 2000 Featured Publication A fuzzy approach has been applied to inverse treatment planning optimization in radiation therapy. The proposed inverse-planning algorithm optimizes both the intensity-modulated beam (IMB) and the normal tissue prescription. In the IMB optimization, we dev ... Full text Link to item Cite

Soft optimization with fuzzy weight function

Journal Article IEEE International Conference on Fuzzy Systems · December 1, 1999 Featured Publication We describe a new class of optimization method based on the theory of classic minimum using a fuzzy weight function. The technique is applied to the problem of normal tissue prescription optimization in conformal radiotherapy. The performance of the new al ... Cite

Treatment field shape verification using elliptic Fourier transform.

Journal Article Med Phys · November 1999 Featured Publication An automated field shape correlation technique based on elliptic Fourier transform (EFT) is developed to verify the radiation treatment field in digital portal images. In this method, the edge of the treatment field is initially extracted from the portal i ... Full text Link to item Cite

Structures of yeast vesicle trafficking proteins.

Journal Article Protein Sci · November 1999 Featured Publication In protein transport between organelles, interactions of v- and t-SNARE proteins are required for fusion of protein-containing vesicles with appropriate target compartments. Mammalian SNARE proteins have been observed to interact with NSF and SNAP, and yea ... Full text Link to item Cite

Two-dimensional direction-based interpolation with local centered moments

Journal Article Graphical Models and Image Processing · January 1, 1999 Featured Publication Interpolation is generally needed to visualize medical images from a limited number of sliced tomographic images such as CT. In this paper, a novel gray-scale image interpolation method, for interpolating two-dimensional images accurately and efficiently, ... Full text Cite

Variation method for inverse treatment planning

Journal Article Medical Physics · January 1, 1999 Featured Publication A new inverse planning method based on the theory of variation is developed for the computation of beam intensities that produce highly conformal dose distributions to the target volume that have an arbitrary complex geometry. It is shown that the objectiv ... Full text Cite

MR image-guided portal verification for brain treatment field.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 1998 Featured Publication PURPOSE: To investigate a method for the generation of digitally reconstructed radiographs directly from MR images (DRR-MRI) to guide a computerized portal verification procedure. METHODS AND MATERIALS: Several major steps were developed to perform an MR i ... Full text Link to item Cite

Oncologic image compression using both wavelet and masking techniques.

Journal Article Med Phys · December 1997 Featured Publication A new algorithm has been developed to compress oncologic images using both wavelet transform and field masking methods. A compactly supported wavelet transform is used to decompose the original image into high- and low-frequency subband images. The region- ... Full text Link to item Cite

Two-dimensional refinement scheme of direction-based interpolation with discrete orthogonal polynomial decomposition

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · December 1, 1997 Featured Publication In this paper, a novel direction-based interpolation approach with discrete orthogonal polynomial decomposition is introduced. A 2D digital image is usually regarded as a sampling of an underlying 2D continuous function, which is called an image field. Whe ... Cite

Automated extraction of pelvic features in portal and simulation images

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · December 1, 1996 Featured Publication A new approach, a pyramid template matching as guided by a snake, is developed for the extraction of pelvic features in both portal and simulation images. Initially, the treatment field edge was extracted using a Canny edge detector. A template modeled usi ... Full text Cite

The effect of detector size to the broadening of the penumbra--a computer simulated study.

Journal Article Med Phys · August 1996 Featured Publication The effect of detector size to the broadening of the measured beam penumbra has been a subject of numerous studies. Based on measured data, linear and quadratic curves have been proposed to describe the relationship between the measured penumbra width, bet ... Full text Link to item Cite

An observer study for direct comparison of clinical efficacy of electronic to film portal images.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 1996 Featured Publication PURPOSE: To directly compare clinical efficacy of electronic to film portal images. METHODS AND MATERIALS: An observer study was designed to compare clinical efficacy of electronic to film portal images acquired using a liquid matrix ion-chamber electronic ... Full text Link to item Cite

Portal image feature extraction by hierarchical region processing technique

Journal Article Proceedings of the IEEE International Conference on Systems, Man and Cybernetics · December 1, 1995 Featured Publication We describe in this paper a novel hierarchical region processing technique for the extraction of features from portal images. Feature extraction is an essential component in the computerized registration of portal images for radiation treatment verificatio ... Cite

Physical penumbra change of beam profile due to film digitization.

Journal Article Med Phys · June 1995 Featured Publication Full text Link to item Cite

Development of a computerized portal verification system for radiation therapy of breast cancers

Conference Proceedings of SPIE - The International Society for Optical Engineering · May 12, 1995 A fully automated system is being developed for the portal verification of tangential breast fields in radiation therapy of breast cancer. The automated verification system involves image acquisition, image feature extraction, feature correlation between r ... Full text Cite

A technique of automating compensator design for lung inhomogeneity correction using an electron portal imaging device.

Journal Article Med Phys · November 1994 Featured Publication A technique of automating compensator design for lung inhomogeneity correction using an electron portal imaging device (EPID) has been investigated. This technique utilizes exit-radiation information as detected by an EPID to determine the thickness of the ... Full text Link to item Cite

Input/output characteristics of a matrix ion-chamber electronic portal imaging device.

Journal Article Med Phys · September 1994 Featured Publication The input/output characteristics of a matrix liquid ion-chamber electronic portal imaging device (EPID) are investigated to elucidate the imaging properties of EPIDs. The radiation input to the detector, represented by dose rate, and the pixel value output ... Full text Link to item Cite

Computerized detection of masses in digital mammograms: automated alignment of breast images and its effect on bilateral-subtraction technique.

Journal Article Med Phys · March 1994 Featured Publication An automated technique for the alignment of right and left breast images has been developed for use in the computerized analysis of bilateral breast images. In this technique, the breast region is first identified in each digital mammogram by use of histog ... Full text Link to item Cite

Effect of case selection on the performance of computer-aided detection schemes.

Journal Article Med Phys · February 1994 Featured Publication The choice of clinical cases used to train and test a computer-aided diagnosis (CAD) scheme can affect the test results (i.e., error rate). In this study, we deliberately modified the components of our testing database to study the effects of this modifica ... Full text Link to item Cite

Computerized detection of masses in digital mammograms: investigation of feature-analysis techniques.

Journal Article J Digit Imaging · February 1994 Featured Publication Mammographic screening of asymptomatic women has shown effectiveness in the reduction of breast cancer mortality. We are developing a computerized scheme for the detection of mammographic masses as an aid to radiologists in mammographic screening programs. ... Full text Link to item Cite

Computer-aided detection and diagnosis of masses and clustered microcalcifications from digital mammograms

Conference Proceedings of SPIE - The International Society for Optical Engineering · July 29, 1993 We are developing an "intelligent" workstation to assist radiologists in diagnosing breast cancer from mammograms. The hardware for the workstation will consist of a film digitizer, a high speed computer, a large volume storage device, a film printer, and ... Full text Cite

Comparison of bilateral-subtraction and single-image processing techniques in the computerized detection of mammographic masses.

Journal Article Invest Radiol · June 1993 Featured Publication RATIONALE AND OBJECTIVES: Identification of regions as possible masses on digitized screen film mammograms is an important initial step in the computerized detection of breast carcinomas. Possible masses may be initially extracted using criteria based on o ... Full text Link to item Cite

Computerized detection and characterization of mass lesions in digital mammography

Conference Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics · January 1, 1992 We are developing computer-aided diagnosis schemes for the detection of breast lesions in digital mammograms. The detection scheme employs a bilateral-subtraction technique that is based on the normal symmetry between the left and right breast images. The ... Full text Cite

Evaluation of imaging properties of a laser film digitizer.

Journal Article Phys Med Biol · January 1992 Featured Publication In this paper we provide a quantitative assessment of the basic imaging properties of a laser film digitizer. The characteristic curve of the digitizer was determined in terms of the relationship between input optical density and output pixel value. Spatia ... Full text Link to item Cite

Direct comparison of conventional and computed radiography with a dual-image recording technique.

Journal Article Radiographics · March 1991 Featured Publication To compare the image quality of computed radiographic (CR) with conventional screen-film images, the authors used a dual-image recording technique. Images were simultaneously acquired with a conventional screen-film combination and a storage-phosphor imagi ... Full text Link to item Cite

Computerized detection of masses in digital mammograms: analysis of bilateral subtraction images.

Journal Article Med Phys · 1991 Featured Publication A computerized scheme is being developed for the detection of masses in digital mammograms. Based on the deviation from the normal architectural symmetry of the right and left breasts, a bilateral subtraction technique is used to enhance the conspicuity of ... Full text Link to item Cite

Data compression: effect on diagnostic accuracy in digital chest radiography.

Journal Article Radiology · January 1991 Featured Publication High-resolution digital images make up very large data sets that are relatively slow to transmit and expensive to store. Data compression techniques are being developed to address this problem, but significant image deterioration can occur at high compress ... Full text Link to item Cite

Comparison of imaging properties of a computed radiography system and screen-film systems.

Journal Article Med Phys · 1991 Featured Publication To compare the diagnostic quality of images obtained with a computed radiography (CR) system based on storage phosphor technology with that obtained with conventional screen-film systems, a dual-image recording technique was devised. With this technique, a ... Full text Link to item Cite

Development of a 'smart' workstation for use in mammography

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · January 1, 1991 Featured Publication We are developing various computer-vision schemes for the detection of masses and microcalcifications in digital mammograms (1-7). However, for the effective and efficient implementation of computer-aided diagnosis (CAD), appropriate man-machine interfaces ... Cite

Computer-vision system for the detection and characterization of masses for use in mammographic screening programs

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · January 1, 1991 Featured Publication Studies have shown that early detection of breast cancer through periodic mammographic screening of asymptomatic women could reduce breast cancer mortality by 30-50%. However, screening yields a high volume of mammograms requiring interpretation. In additi ... Cite

Investigation of methods for the computerized detection and analysis of mammographic masses

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · December 1, 1990 Featured Publication At present, mammography is the most effective method for the early detection of breast cancer. Detection and classification of masses in mammograms are among the most important and difficult tasks performed by radiologists. Various studies have indicated t ... Cite

Evaluation of basic imaging properties of a new digital chest system

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · July 1, 1990 Featured Publication A prototype digital chest system, which uses storage phosphor technology and has the advantages over existing computed radiography systems (CR) of compactness and immediate image display, is being evaluated in our laboratory. We evaluated the imaging prope ... Full text Cite

Measurement of the presampling modulation transfer function of film digitizers using a curve fitting technique.

Journal Article Med Phys · 1990 Featured Publication A curve fitting technique combined with an angulated slit image has been developed for the measurement of the presampling modulation transfer function (MTF) of film digitizers. The noisy line spread functions (LSFs) acquired from an angulated slit image ar ... Full text Link to item Cite

Pulmonary nodules: computer-aided detection in digital chest images.

Journal Article Radiographics · January 1990 Featured Publication Currently, radiologists fail to detect pulmonary nodules in up to 30% of cases with actually positive findings. Diagnoses may be missed due to camouflaging effects of anatomic background, subjective and varying decision criteria, or distractions in clinica ... Full text Link to item Cite

Image-processing techniques used in the computer-aided detection of radiographic lesions in anatomic background

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · June 27, 1988 Full text Cite

Is a single isocenter sufficient for volumetric modulated arc therapy radiosurgery when multiple itracranial metastases are spatially dispersed?

Journal Article Med Dosim Previous work demonstrated improved dosimetry of single isocenter volumetric modulated arc therapy (VMAT) of multiple intracranial targets when they are located ≤ 4cm from isocenter because of narrower multileaf collimators (MLCs). In follow-up, we sought ... Full text Link to item Cite

Radiosurgery treatment planning using conformal arc informed volumetric modulated arc therapy.

Journal Article Med Dosim Linac based radiosurgery to multiple metastases is commonly planned with volumetric modulated arc therapy (VMAT) as it effectively achieves high conformality to complex target arrangements. However, as the number of targets increases, VMAT can struggle to ... Full text Link to item Cite