Scholars@Duke
K. Ranga Rama Krishnan

K. Ranga Rama Krishnan

Professor Emeritus of Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences
krish001@mc.duke.edu
Box 2741 Med Ctr, Durham, NC 27710
2424 Erwin Road, Durham, NC 27710

Selected Publications

Circular-SWAT for deep learning based diagnostic classification of Alzheimer's disease: application to metabolome data.

Journal Article EBioMedicine · November 2023 BACKGROUND: Deep learning has shown potential in various scientific domains but faces challenges when applied to complex, high-dimensional multi-omics data. Alzheimer's Disease (AD) is a neurodegenerative disorder that lacks targeted therapeutic options. T ... Full text Link to item Cite

Genomics-based identification of a potential causal role for acylcarnitine metabolism in depression.

Journal Article J Affect Disord · June 15, 2022 BACKGROUND: Altered metabolism of acylcarnitines - transporting fatty acids to mitochondria - may link cellular energy dysfunction to depression. We examined the potential causal role of acylcarnitine metabolism in depression by leveraging genomics and Men ... Full text Link to item Cite

How Academic Health Systems Can Be Ready for the Next Pandemic.

Journal Article Acad Med · April 1, 2022 The COVID-19 pandemic created significant challenges for academic health systems (AHSs) across their tripartite mission of providing clinical care, conducting research, and educating learners. Despite these challenges, AHSs played an invaluable role in res ... Full text Link to item Cite

Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature.

Journal Article Scientific reports · October 2021 It is unknown whether indoles, metabolites of tryptophan that are derived entirely from bacterial metabolism in the gut, are associated with symptoms of depression and anxiety. Serum samples (baseline, 12 weeks) were drawn from participants (n = 196) rando ... Full text Cite

Alterations in acylcarnitines, amines, and lipids inform about the mechanism of action of citalopram/escitalopram in major depression.

Journal Article Transl Psychiatry · March 2, 2021 Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for major depressive disorder (MDD), yet their mechanisms of action are not fully understood and their therapeutic benefit varies among individuals. We used a targeted metabolomic ... Full text Open Access Link to item Cite

Acylcarnitine metabolomic profiles inform clinically-defined major depressive phenotypes.

Journal Article J Affect Disord · March 1, 2020 BACKGROUND: Acylcarnitines have important functions in mitochondrial energetics and β-oxidation, and have been implicated to play a significant role in metabolic functions of the brain. This retrospective study examined whether plasma acylcarnitine profile ... Full text Link to item Cite

BCI Facilitates the Improvement of Cognitive Functions in Children and Elderly

Conference 8th International Winter Conference on Brain-Computer Interface, BCI 2020 · February 1, 2020 Brain-Computer Interface (BCI) technology has been under exploration as an alternative approach to restore or enhance brain functions, possibly. One of the attempts is to use BCI to help improve human cognitive functions by leveraging on the BCI capability ... Full text Cite

Metabolomic signature of exposure and response to citalopram/escitalopram in depressed outpatients.

Journal Article Transl Psychiatry · July 4, 2019 Metabolomics provides valuable tools for the study of drug effects, unraveling the mechanism of action and variation in response due to treatment. In this study we used electrochemistry-based targeted metabolomics to gain insights into the mechanisms of ac ... Full text Open Access Link to item Cite

Exposure therapy with personalized real-time arousal detection and feedback to alleviate social anxiety symptoms in an analogue adult sample: Pilot proof-of-concept randomized controlled trial

Journal Article JMIR Mental Health · June 1, 2019 Background: Exposure therapy is highly effective for social anxiety disorder. However, there is room for improvement. Objective: This is a first attempt to examine the feasibility of an arousal feedback-based exposure therapy to alleviate social anxiety sy ... Full text Cite

A randomized controlled trial of a brain-computer interface based attention training program for ADHD.

Journal Article PLoS One · 2019 OBJECTIVE: The use of brain-computer interface in neurofeedback therapy for attention deficit hyperactivity disorder (ADHD) is a relatively new approach. We conducted a randomized controlled trial (RCT) to determine whether an 8-week brain computer interfa ... Full text Link to item Cite

Pilot Study of Metabolomic Clusters as State Markers of Major Depression and Outcomes to CBT Treatment.

Journal Article Front Neurosci · 2019 Major depressive disorder (MDD) is a common and disabling syndrome with multiple etiologies that is defined by clinically elicited signs and symptoms. In hopes of developing a list of candidate biological measures that reflect and relate closely to the sev ... Full text Open Access Link to item Cite

Large-Scale Network Topology Reveals Heterogeneity in Individuals With at Risk Mental State for Psychosis: Findings From the Longitudinal Youth-at-Risk Study.

Journal Article Cereb Cortex · December 1, 2018 Emerging evidence demonstrates heterogeneity in clinical outcomes of prodromal psychosis that only a small percentage of at-risk individuals eventually progress to full-blown psychosis. To examine the neurobiological underpinnings of this heterogeneity fro ... Full text Link to item Cite

Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders.

Journal Article J Affect Disord · October 1, 2018 BACKGROUND: Substantial research progress can be achieved if available clinical datasets can be mapped to the National Institute of Mental Health Research-Domain-Criteria (RDoC) constructs. This mapping would allow investigators to both explore more narrow ... Full text Link to item Cite

Brain-computer-interface-based intervention re-normalizes brain functional network topology in children with attention deficit/hyperactivity disorder.

Journal Article Transl Psychiatry · August 10, 2018 A brain-computer-interface (BCI)-based attention training game system has shown promise for treating attention deficit/hyperactivity disorder (ADHD) children with inattentive symptoms. However, little is known about brain network organizational changes und ... Full text Link to item Cite

Effectiveness of a Personalized Brain-Computer Interface System for Cognitive Training in Healthy Elderly: A Randomized Controlled Trial.

Journal Article J Alzheimers Dis · 2018 BACKGROUND: Cognitive training has been demonstrated to improve cognitive performance in older adults. To date, no study has explored personalized training that targets the brain activity of each individual. OBJECTIVE: This is the first large-scale trial t ... Full text Link to item Cite

GERI-BD: A Randomized Double-Blind Controlled Trial of Lithium and Divalproex in the Treatment of Mania in Older Patients With Bipolar Disorder.

Journal Article Am J Psychiatry · November 1, 2017 OBJECTIVE: Clinicians treating older patients with bipolar disorder with mood stabilizers need evidence from age-specific randomized controlled trials. The authors describe findings from a first such study of late-life mania. METHOD: The authors compared t ... Full text Link to item Cite

Stress, Mood, and Pathways to Depression

Chapter · January 1, 2017 Mood disorders are very common. More than 10-20% of the population suffers from mood disorders at one time or another. These disorders are heterogeneous and multifactorial. The most common form of mood dysregulation is depression. At least four intersectin ... Full text Cite

Adjunctive 5-Hydroxytryptophan Slow-Release for Treatment-Resistant Depression: Clinical and Preclinical Rationale.

Journal Article Trends Pharmacol Sci · November 2016 Serotonin transporter (SERT) inhibitors treat depression by elevating brain extracellular 5-hydroxytryptamine (5-HTExt). However, only one-third of patients respond adequately. Treatment-resistant depression (TRD) is a major unmet need. Interestingly, elev ... Full text Link to item Cite

Disrupted salience network functional connectivity and white-matter microstructure in persons at risk for psychosis: findings from the LYRIKS study.

Journal Article Psychol Med · October 2016 BACKGROUND: Salience network (SN) dysconnectivity has been hypothesized to contribute to schizophrenia. Nevertheless, little is known about the functional and structural dysconnectivity of SN in subjects at risk for psychosis. We hypothesized that SN funct ... Full text Link to item Cite

How Does Electroconvulsive Therapy Work?

Journal Article Biol Psychiatry · February 15, 2016 Full text Link to item Cite

Treatment of bipolar disorder in special populations

Chapter · January 1, 2016 Though often considered a young person’s disease because its mean age of onset is in late adolescence, bipolar disorder (BD) frequently demonstrates recurrent episodes and morbidities that continue throughout the lifetime of the patient and into old age. I ... Full text Cite

Lack of Evidence for Regional Brain Volume or Cortical Thickness Abnormalities in Youths at Clinical High Risk for Psychosis: Findings From the Longitudinal Youth at Risk Study.

Journal Article Schizophr Bull · November 2015 There is cumulative evidence that young people in an "at-risk mental state" (ARMS) for psychosis show structural brain abnormalities in frontolimbic areas, comparable to, but less extensive than those reported in established schizophrenia. However, most av ... Full text Link to item Cite

Inflammation Markers and Major Depressive Disorder in Patients With Chronic Heart Failure: Results From the Sertraline Against Depression and Heart Disease in Chronic Heart Failure Study.

Journal Article Psychosom Med · September 2015 BACKGROUND: Major depressive disorder (MDD) and chronic heart failure (CHF) have in common heightening states of inflammation, manifested by elevated inflammation markers such as C-reactive protein. This study compared inflammatory biomarker profiles in pa ... Full text Link to item Cite

Suicidal ideation and sex differences in relation to 18 major psychiatric disorders in college and university students: anonymous web-based assessment.

Journal Article J Nerv Ment Dis · April 2015 College/university students are at high risk for psychiatric disorder and suicide secondary to age, campus stressors, and social pressures. We therefore report frequencies of 18 Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Re ... Full text Link to item Cite

Brain-computer interface and its applications in cognitive training

Journal Article 3rd International Winter Conference on Brain-Computer Interface, BCI 2015 · March 30, 2015 We investigated the use of Brain-Computer Interface (BCI) in cognitive training. We developed a BCI to quantify a person's attention level. Based on this algorithm, a feedforward mechanism is then used to build gaming interfaces for cognitive training. Sev ... Full text Cite

A knowledge network for a dynamic taxonomy of psychiatric disease.

Journal Article Dialogues Clin Neurosci · March 2015 Current taxonomic approaches in medicine and psychiatry are limited in validity and utility. They do serve simple communication purposes for medical coding, teaching, and reimbursement, but they are not suited for the modern era with its rapid explosion of ... Full text Link to item Cite

Incubating the research independence of a medical scientist training program graduate: a case study.

Journal Article Acad Med · February 2015 PROBLEM: Physician-scientists play a critical role in discovering new biological knowledge and translating findings into medical practices that can improve clinical outcomes. Collectively, the National Institutes of Health (NIH) and its affiliated Medical ... Full text Link to item Cite

A pilot randomized controlled trial using EEG-based brain-computer interface training for a Chinese-speaking group of healthy elderly.

Journal Article Clin Interv Aging · 2015 BACKGROUND: There is growing evidence that cognitive training (CT) can improve the cognitive functioning of the elderly. CT may be influenced by cultural and linguistic factors, but research examining CT programs has mostly been conducted on Western popula ... Full text Link to item Cite

Proceedings of the 2013 CINP summit: innovative partnerships to accelerate CNS drug discovery for improved patient care.

Journal Article Int J Neuropsychopharmacol · December 25, 2014 Central nervous system (CNS) diseases and, in particular, mental health disorders, are becoming recognized as the health challenge of the 21(st) century. Currently, at least 10% of the global population is affected by a mental health disorder, a figure tha ... Full text Link to item Cite

Molecular imaging for depressive disorders.

Journal Article AJNR Am J Neuroradiol · June 2014 Molecular imaging is the visualization, characterization, and measurement of biologic processes at the molecular and cellular levels in humans and other living systems. Molecular imaging techniques such as MR spectroscopy and PET have been used to explore ... Full text Link to item Cite

Development of a virtual reality assessment of everyday living skills.

Journal Article J Vis Exp · April 23, 2014 Cognitive impairments affect the majority of patients with schizophrenia and these impairments predict poor long term psychosocial outcomes.  Treatment studies aimed at cognitive impairment in patients with schizophrenia not only require demonstration of i ... Full text Link to item Cite

Development of a virtual reality assessment of everyday living skills

Journal Article Journal of visualized experiments : JoVE · 2014 Cognitive impairments affect the majority of patients with schizophrenia and these impairments predict poor long term psychosocial outcomes.  Treatment studies aimed at cognitive impairment in patients with schizophrenia not only require demonstration of i ... Full text Cite

Preserved working memory and altered brain activation in persons at risk for psychosis.

Journal Article Am J Psychiatry · November 2013 OBJECTIVE: Patients with schizophrenia exhibit impairments in working memory that often appear in attenuated form in persons at high risk for the illness. The authors hypothesized that deviations in task-related brain activation and deactivation would occu ... Full text Link to item Cite

MRI-defined vascular depression

Chapter · October 15, 2013 OBJECTIVE: The authors' goal was to characterize the clinical and demographic features of vascular depression. METHOD: They classified 89 depressed patients into two groups-those with vascular (N = 32) and nonvascular (N = 57) depression-on the basis of ex ... Cite

Morphometric analysis of vascular pathology in the orbitofrontal cortex of older subjects with major depression.

Journal Article Int J Geriatr Psychiatry · September 2013 OBJECTIVE: Late-life depression has been associated with risk for cerebrovascular pathology, as demonstrated in neuroimaging studies of older depressed patients, as well as mood disorder following cerebrovascular accidents. However, more research is needed ... Full text Link to item Cite

Full central neurokinin-1 receptor blockade is required for efficacy in depression: evidence from orvepitant clinical studies.

Journal Article J Psychopharmacol · May 2013 Full, persistent blockade of central neurokinin-1 (NK1) receptors may be a potential antidepressant mechanism. The selective NK1 antagonist orvepitant (GW823296) was used to test this hypothesis. A preliminary positron emission tomography study in eight ma ... Full text Link to item Cite

Fiber tract-specific white matter lesion severity Findings in late-life depression and by AGTR1 A1166C genotype.

Journal Article Hum Brain Mapp · February 2013 Past work demonstrated that late-life depression is associated with greater severity of ischemic cerebral hyperintense white matter lesions, particularly frontal lesions. However, these lesions are also associated with other neuropsychiatric deficits, so t ... Full text Link to item Cite

Associations between elevated homocysteine, cognitive impairment, and reduced white matter volume in healthy old adults.

Journal Article Am J Geriatr Psychiatry · February 2013 OBJECTIVES: Elevated homocysteine has emerged as a risk factor for cognitive impairment even in healthy elderly persons. Reduced brain volume and white matter hyperintensities also occur in healthy elderly as well, but the interrelationships between these ... Full text Link to item Cite

Pharmacometabolomic mapping of early biochemical changes induced by sertraline and placebo.

Journal Article Transl Psychiatry · January 22, 2013 In this study, we characterized early biochemical changes associated with sertraline and placebo administration and changes associated with a reduction in depressive symptoms in patients with major depressive disorder (MDD). MDD patients received sertralin ... Full text Link to item Cite

A brain-computer interface based cognitive training system for healthy elderly: a randomized control pilot study for usability and preliminary efficacy.

Journal Article PLoS One · 2013 UNLABELLED: Cognitive decline in aging is a pressing issue associated with significant healthcare costs and deterioration in quality of life. Previously, we reported the successful use of a novel brain-computer interface (BCI) training system in improving ... Full text Link to item Cite

Academic medicine: vision to reality.

Journal Article Ann Acad Med Singap · January 2013 Link to item Cite

Pharmacometabolomics of response to sertraline and to placebo in major depressive disorder - possible role for methoxyindole pathway.

Journal Article PLoS One · 2013 Therapeutic response to selective serotonin (5-HT) reuptake inhibitors in Major Depressive Disorder (MDD) varies considerably among patients, and the onset of antidepressant therapeutic action is delayed until after 2 to 4 weeks of treatment. The objective ... Full text Open Access Link to item Cite

Health status and depression remission in patients with chronic heart failure: patient-reported outcomes from the SADHART-CHF trial.

Journal Article Circ Heart Fail · November 2012 BACKGROUND: Depression is a common comorbidity in heart failure and is strongly associated with increased mortality, morbidity, and reduced health status. Whether depression treatment may result in improvement of health status in heart failure patients wit ... Full text Link to item Cite

Treatment course with antidepressant therapy in late-life depression.

Journal Article Am J Psychiatry · November 2012 OBJECTIVE: In order to assess the effect of gray matter volumes and cortical thickness on antidepressant treatment response in late-life depression, the authors examined the relationship between brain regions identified a priori and Montgomery-Åsberg Depre ... Full text Link to item Cite

Neural correlates associated with cognitive decline in late-life depression.

Journal Article Am J Geriatr Psychiatry · August 2012 OBJECTIVES: Persistent cognitive impairment (PCI) after remission of depressive symptoms is a major adverse outcome of late-life depression (LLD). The purpose of this study was to examine neural substrates associated with PCI in LLD. DESIGN: Longitudinal s ... Full text Link to item Cite

Downregulation of TOMM40 expression in the blood of Alzheimer disease subjects compared with matched controls.

Journal Article J Psychiatr Res · June 2012 Translocase of outer mitochondrial membrane 40 homolog (TOMM40) gene has been reported in several GWAS to be associated with Alzheimer disease (AD). Gene expression studies thus far only showed TOMM40 differential expression in one study on brain cortex an ... Full text Link to item Cite

AGTR1 gene variation: association with depression and frontotemporal morphology.

Journal Article Psychiatry Res · May 31, 2012 The renin-angiotensin system (RAS) is implicated in the response to physiological and psychosocial stressors, but its role in stress-related psychiatric disorders is poorly understood. We examined if variation in AGTR1, the gene coding for the type 1 angio ... Full text Link to item Cite

Efficacy, safety, and tolerability of a triple reuptake inhibitor GSK372475 in the treatment of patients with major depressive disorder: two randomized, placebo- and active-controlled clinical trials.

Journal Article J Psychopharmacol · May 2012 GSK372475 is a triple reuptake inhibitor with approximately equipotent inhibition of serotonin, norepinephrine, and dopamine transporters. Two randomized, placebo- and active-controlled, double-blind studies examined the efficacy and safety of GSK372475 in ... Full text Link to item Cite

Impact of BDNF Val66Met and 5-HTTLPR polymorphism variants on neural substrates related to sadness and executive function.

Journal Article Genes Brain Behav · April 2012 The brain-derived neurotrophic factor (BDNF) Val(66) Met allelic variation is linked to both the occurrence of mood disorders and antidepressant response. These findings are not universally observed, and the mechanism by which this variation results in inc ... Full text Link to item Cite

Plasma omega-3 polyunsaturated fatty acids and survival in patients with chronic heart failure and major depressive disorder.

Journal Article J Cardiovasc Transl Res · February 2012 The omega-3 fatty acid (FA) concentration is low in patients with coronary heart disease (CHD). Supplement of omega-3 FA improves cardiovascular outcomes in patients with CHD and heart failure (HF). However, plasma omega-3 FA and its role for prognosis in ... Full text Link to item Cite

Responses of mental stress-induced myocardial ischemia to escitalopram treatment: background, design, and method for the Responses of Mental Stress Induced Myocardial Ischemia to Escitalopram Treatment trial.

Journal Article Am Heart J · January 2012 BACKGROUND: Mental stress-induced myocardial ischemia (MSIMI) is common in patients with clinically stable coronary heart disease (CHD) and is associated with poor outcomes. Depression is a risk factor of MSIMI. The REMIT trial investigates whether selecti ... Full text Link to item Cite

Association of depression and survival in patients with chronic heart failure over 12 Years.

Journal Article Psychosomatics · 2012 OBJECTIVE: To examine the relationship between depression and survival in patients with chronic heart failure (HF) over a 12-year follow-up period. BACKGROUND: The survival associated with depression has been demonstrated in HF patients for up to 7 years. ... Full text Link to item Cite

Cerebrospinal fluid metabolome in mood disorders-remission state has a unique metabolic profile.

Journal Article Sci Rep · 2012 Targeted metabolomics provides an approach to quantify metabolites involved in specific molecular pathways. We applied an electrochemistry-based, targeted metabolomics platform to define changes in tryptophan, tyrosine, purine and related pathways in the d ... Full text Link to item Cite

Bipolar disorder, brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and brain morphology.

Journal Article PLoS One · 2012 In this study of the effect of bipolar status and presence of BDNF Val66Met polymorphism on differences in regional brain volumes, we hypothesized based on previous studies that 1) bipolar subjects will have smaller regional brain volumes than healthy cont ... Full text Link to item Cite

The effectiveness of antidepressant monotherapy in a naturalistic outpatient setting.

Journal Article Prim Care Companion CNS Disord · 2012 OBJECTIVE: To assess a representative sample of clinically depressed outpatients during acute treatment with antidepressant medication monotherapy to determine clinical outcomes and evaluate relationships between outcomes and selected baseline/treatment fe ... Full text Link to item Cite

A brain-computer interface based attention training program for treating attention deficit hyperactivity disorder.

Journal Article PLoS One · 2012 UNLABELLED: Attention deficit hyperactivity disorder (ADHD) symptoms can be difficult to treat. We previously reported that a 20-session brain-computer interface (BCI) attention training programme improved ADHD symptoms. Here, we investigated a new more in ... Full text Link to item Cite

Associations Between Elevated Homocysteine, Cognitive Impairment, and Reduced White Matter Volume in Healthy Old Adults.

Journal Article Am J Geriatr Psychiatry · December 8, 2011 OBJECTIVES:: Elevated homocysteine has emerged as a risk factor for cognitive impairment even in healthy elderly persons. Reduced brain volume and white matter hyperintensities also occur in healthy elderly as well, but the interrelationships between these ... Full text Link to item Cite

Treatment of depression in the medically Ill

Journal Article · December 1, 2011 Depression and ischemic heart disease (IHD) are the two most prevalent health problems afflicting patients not only in the United States but worldwide (1). The lifetime prevalence of major depressive disorder in the general population of the United States ... Full text Cite

A functional alternative splicing mutation in human tryptophan hydroxylase-2.

Journal Article Mol Psychiatry · December 2011 The brain serotonergic system has an essential role in the physiological functions of the central nervous system and dysregulation of serotonin (5-HT) homeostasis has been implicated in many neuropsychiatric disorders. The tryptophan hydroxylase-2 (TPH2) g ... Full text Link to item Cite

Results from 2 randomized, double-blind, placebo-controlled studies of the novel NK1 receptor antagonist casopitant in patients with major depressive disorder.

Journal Article J Clin Psychopharmacol · December 2011 Clinical study results for neurokinin (NK) receptor antagonists in the treatment of depression have been mixed, with Phase III studies failing to fulfill the early promise demonstrated in Phase II studies. Casopitant, a selective NK1 antagonist that achiev ... Full text Link to item Cite

Amygdala volume in late-life depression: relationship with age of onset.

Journal Article Am J Geriatr Psychiatry · September 2011 OBJECTIVES: Depression is common in the elderly population. Although numerous neuroimaging studies have examined depressed elders, there is limited research examining how amygdala volume may be related to depression. DESIGN: A cross-sectional examination o ... Full text Link to item Cite

Reduction of dorsolateral prefrontal cortex gray matter in late-life depression.

Journal Article Psychiatry Res · July 30, 2011 Postmortem studies have documented abnormalities in the dorsolateral prefrontal cortex (dlPFC) in depressed subjects. In this study we used magnetic resonance imaging to test for dlPFC volume differences between older depressed and non-depressed individual ... Full text Link to item Cite

Comprehensive model of how reality distortion and symptoms occur in schizophrenia: could impairment in learning-dependent predictive perception account for the manifestations of schizophrenia?

Journal Article Psychiatry Clin Neurosci · June 2011 Conventional wisdom has not laid out a clear and uniform profile of schizophrenia as a unitary entity. One of the key first steps in elucidating the neurobiology of this entity would be to characterize the essential and common elements in the group of enti ... Full text Link to item Cite

BDNF Val66Met genotype and 6-month remission rates in late-life depression.

Journal Article Pharmacogenomics J · April 2011 Although not observed in younger adult cohorts, in older individuals the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with major depressive disorder (MDD) risk. It is further associated with subjective social support and mag ... Full text Link to item Cite

Effects of pregabalin on heart rate variability in patients with painful diabetic neuropathy.

Journal Article J Clin Psychopharmacol · April 2011 UNLABELLED: Many studies have demonstrated that low heart rate variability (HRV) is a risk for high mortality and morbidity in patients with cardiovascular diseases. The primary purpose of the study was to evaluate whether pregabalin improves HRV in patien ... Full text Link to item Cite

Characteristics of depression remission and its relation with cardiovascular outcome among patients with chronic heart failure (from the SADHART-CHF Study).

Journal Article Am J Cardiol · February 15, 2011 Depression is prevalent in patients with heart failure and is associated with a significant increase in hospitalizations and death. Primary results of the Sertraline Against Depression and Heart Disease in Chronic Heart Failure (SADHART-CHF) trial revealed ... Full text Link to item Cite

Hierarchical temporal processing deficit model of reality distortion and psychoses.

Journal Article Mol Psychiatry · February 2011 We posit in this article that hierarchical temporal processing deficit is the underlying basis of reality distortion and psychoses. Schizophrenia is a prototypical reality distortion disorder in which the patient manifests with auditory hallucinations, del ... Full text Link to item Cite

One-year change in anterior cingulate cortex white matter microstructure: relationship with late-life depression outcomes.

Journal Article Am J Geriatr Psychiatry · January 2011 OBJECTIVE: differences in white matter structure measured with diffusion tensor imaging (DTI) are associated with late-life depression, but results examining how these differences relate to antidepressant remission are mixed. To better describe these relat ... Full text Link to item Cite

Pretreatment metabotype as a predictor of response to sertraline or placebo in depressed outpatients: a proof of concept.

Journal Article Transl Psychiatry · 2011 The purpose of this study was to determine whether the baseline metabolic profile (that is, metabotype) of a patient with major depressive disorder (MDD) would define how an individual will respond to treatment. Outpatients with MDD were randomly assigned ... Full text Link to item Cite

Variability in frontotemporal brain structure: the importance of recruitment of African Americans in neuroscience research.

Journal Article PLoS One · October 26, 2010 BACKGROUND: Variation in brain structure is both genetically and environmentally influenced. The question about potential differences in brain anatomy across populations of differing race and ethnicity remains a controversial issue. There are few studies s ... Full text Open Access Link to item Cite

Functional evidence implicating a novel TOR1A mutation in idiopathic, late-onset focal dystonia.

Journal Article J Med Genet · September 2010 BACKGROUND: TOR1A encodes a chaperone-like AAA-ATPase whose Delta GAG (Delta E) mutation is responsible for an early onset, generalised dystonia syndrome. Because of the established role of the TOR1A gene in heritable generalised dystonia (DYT1), a potenti ... Full text Link to item Cite

Altered interactions of tryptophan metabolites in first-episode neuroleptic-naive patients with schizophrenia.

Journal Article Mol Psychiatry · September 2010 Schizophrenia is characterized by complex and dynamically interacting perturbations in multiple neurochemical systems. In the past, evidence for these alterations has been collected piecemeal, limiting our understanding of the interactions among relevant b ... Full text Link to item Cite

Safety and efficacy of sertraline for depression in patients with heart failure: results of the SADHART-CHF (Sertraline Against Depression and Heart Disease in Chronic Heart Failure) trial.

Journal Article J Am Coll Cardiol · August 24, 2010 OBJECTIVES: The objective was to test the hypothesis that heart failure (HF) patients treated with sertraline will have lower depression scores and fewer cardiovascular events compared with placebo. BACKGROUND: Depression is common among HF patients. It is ... Full text Link to item Cite

Angiotensin receptor gene polymorphisms and 2-year change in hyperintense lesion volume in men.

Journal Article Mol Psychiatry · August 2010 This longitudinal study examined the relationship between 2-year change in white matter hyperintense lesion (WML) volume and polymorphisms in genes coding for the angiotensin-II type 1 and type 2 receptors, AGTR1 A1166C and AGTR2 C3123A, respectively. 137 ... Full text Link to item Cite

Fish oil, blood vessels, and depression.

Journal Article Biol Psychiatry · July 15, 2010 Full text Link to item Cite

Alzheimer's disease-the inexorable epidemic.

Journal Article Ann Acad Med Singap · July 2010 Link to item Cite

Safety of selective serotonin reuptake inhibitor use prior to coronary artery bypass grafting.

Journal Article Clin Cardiol · June 2010 BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) have been shown to increase bleeding risks. This study examined the association of perioperative coronary artery bypass grafting (CABG) bleeding risks and SSRI use prior to CABG. HYPOTHESIS: SSRI ... Full text Link to item Cite

Metabolomic differences in heart failure patients with and without major depression.

Journal Article J Geriatr Psychiatry Neurol · June 2010 Metabolomics is an emerging technology that allows researchers to characterize hundreds of small molecules that comprise the metabolome. We sought to determine metabolic differences in depressed and nondepressed participants. The sample consisted of a depr ... Full text Link to item Cite

Psychogenomics and psychiatric practice, a new paradigm

Journal Article Current Psychiatry Reviews · May 1, 2010 Full text Cite

Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial.

Journal Article Arch Gen Psychiatry · March 2010 CONTEXT: Research on vascular depression has used 2 approaches to subtype late-life depression, based on executive dysfunction or white matter hyperintensity severity. OBJECTIVE: To evaluate the relationship of neuropsychological performance and white matt ... Full text Link to item Cite

Certificate course in outcomes research.

Journal Article Med Teach · January 2010 Link to item Cite

Effectiveness of a brain-computer interface based programme for the treatment of ADHD: a pilot study.

Journal Article Psychopharmacol Bull · 2010 Majority of children with attention deficit hyperactivity disorder (ADHD) have significant inattentive symptoms. We developed a progressive series of activities involving brain-computer interface-based games which could train users to improve their concent ... Link to item Cite

Gray and white matter brain volumes in older adults with bipolar disorder.

Journal Article Int J Geriatr Psychiatry · December 2009 OBJECTIVES: Structural magnetic resonance imaging (MRI) studies have been inconsistent in demonstrating volumetric differences in subjects with bipolar disorder. Most studies have not found difference in total gray or white matter in bipolar patients compa ... Full text Link to item Cite

Opioid use affects antioxidant activity and purine metabolism: preliminary results.

Journal Article Hum Psychopharmacol · December 2009 OBJECTIVE: More must be learned about metabolic and biochemical alterations that contribute to the development and expression of drug dependence. Experimental opioid administration influences mechanisms and indices of oxidative stress, such as antioxidant ... Full text Link to item Cite

Psychiatric Ddisorders

Journal Article · December 1, 2009 Full text Cite

Alterations in tryptophan and purine metabolism in cocaine addiction: a metabolomic study.

Journal Article Psychopharmacology (Berl) · October 2009 BACKGROUND: Mapping metabolic "signatures" can provide new insights into addictive mechanisms and potentially identify biomarkers and therapeutic targets. OBJECTIVE: We examined the differences in metabolites related to the tyrosine, tryptophan, purine, an ... Full text Link to item Cite

The COMT Val158Met polymorphism and cognition in depressed and nondepressed older adults.

Journal Article Int J Geriatr Psychiatry · October 2009 OBJECTIVE: The objective of the current study was to examine the relationship between the COMT Val(158)Met polymorphism and neuropsychological performance in depressed and nondepressed older adults. METHODS: One hundred and twenty-six clinically depressed ... Full text Link to item Cite

Neural correlates of idiographic goal priming in depression: goal-specific dysfunctions in the orbitofrontal cortex.

Journal Article Soc Cogn Affect Neurosci · September 2009 We used functional magnetic resonance imaging (fMRI) to determine whether depressed (vs non-depressed) adults showed differences in cortical activation in response to stimuli representing personal goals. Drawing upon regulatory focus theory as well as prev ... Full text Link to item Cite

Memory-prediction errors and their consequences in schizophrenia.

Journal Article Neuropsychol Rev · September 2009 Cognitive deficits play a central role in the onset of schizophrenia. Cognitive impairment precedes the onset of psychosis in at least a subgroup of patients, and accounts for considerable dysfunction. Yet cognitive deficits as currently measured are not s ... Full text Link to item Cite

Reductions in neuronal density in elderly depressed are region specific.

Journal Article Int J Geriatr Psychiatry · August 2009 OBJECTIVE: Frontal regions, including the orbitofrontal cortex (ORB) and dorsolateral prefrontal cortex (dlPFC) have been implicated in the neuropathology of geriatric depression. Prominent reductions in pyramidal neuron density have been recently reported ... Full text Link to item Cite

Schizophrenia is a disorder of higher order hierarchical processing.

Journal Article Med Hypotheses · June 2009 Schizophrenia is a mental disorder in which the patient manifests with auditory hallucinations, paranoid or bizarre delusions, and disorganized speech and thinking. It is associated with significant social dysfunction. There are many hypotheses regarding s ... Full text Link to item Cite

Biochemical abnormalities of the medial temporal lobe and medial prefrontal cortex in late-life depression.

Journal Article Psychiatry Res · April 30, 2009 We utilized single-voxel (1)H magnetic resonance spectroscopy (MRS) to investigate biochemical abnormalities related to late-life depression in the medial prefrontal cortex and medial temporal lobe. Fourteen elderly subjects whose depression responded to t ... Full text Link to item Cite

Temporal lobe volume in bipolar disorder: relationship with diagnosis and antipsychotic medication use.

Journal Article J Affect Disord · April 2009 BACKGROUND: We tested for differences in temporal lobe volume in bipolar disorder and the relationship between these volumes and psychotropic medication use. METHODS: 125 subjects with bipolar disorder and 87 comparison subjects with no psychiatric illness ... Full text Link to item Cite

Neuropsychological correlates of magnetic resonance imaging-defined subcortical ischemic depression.

Journal Article Int J Geriatr Psychiatry · March 2009 OBJECTIVE: The goal of the current study was to examine the neuropsychological profile of magnetic resonance imaging (MRI)-defined subcortical ischemic depression (SID). METHODS: Clinically depressed older adults with MRI-defined SID (n = 70) and depressed ... Full text Link to item Cite

Reduction of Dorsolateral Prefrontal Cortex Gray Matter in Late-Life Depression

Journal Article AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · March 1, 2009 Link to item Cite

APOE related hippocampal shape alteration in geriatric depression.

Journal Article Neuroimage · February 1, 2009 Late-onset depression often precedes the onset of dementia associated with the hippocampal degeneration. Using large deformation diffeomorphic metric mapping (LDDMM), we evaluated apolipoprotein E epsilon-4 allele (apoE E4) effects on hippocampal volume an ... Full text Link to item Cite

Hyperintense MRI lesions in bipolar disorder: A meta-analysis and review.

Journal Article Int Rev Psychiatry · 2009 BACKGROUND: Cortical and subcortical hyperintensities in magnetic resonance imaging (MRI) scans are thought to represent areas of ischemic damage to brain tissue. Researchers have focused on the possible role these lesions may have in psychiatric disorders ... Full text Link to item Cite

Metabolomics: a global biochemical approach to the study of central nervous system diseases.

Journal Article Neuropsychopharmacology · January 2009 Metabolomics, the omics science of biochemistry, is a global approach to understanding regulation of metabolic pathways and metabolic networks of a biological system. Metabolomics complements data derived from genomics, transcriptomics, and proteomics to a ... Full text Link to item Cite

Decision-making and risk aversion among depressive adults.

Journal Article J Behav Ther Exp Psychiatry · December 2008 Depression is associated with behavioral avoidance of potentially rewarding environmental contexts. The present study examined the performance of depressive individuals and controls on a neuropsychological measure of decision-making that favors risk avoida ... Full text Link to item Cite

Stressful life events in older bipolar patients.

Journal Article Int J Geriatr Psychiatry · December 2008 OBJECTIVE: Theories about the impact of stressful life events (SLE) in bipolar disorder have focused on their role early in the disease. Few studies have examined SLE in older bipolar patients. We wanted to assess the impact of SLE in late life bipolar dis ... Full text Link to item Cite

Psychiatric Disorders

Chapter · November 11, 2008 Full text Cite

Antidepressant use, depression, and survival in patients with heart failure.

Journal Article Arch Intern Med · November 10, 2008 BACKGROUND: Recent studies suggest that the use of antidepressants may be associated with increased mortality in patients with cardiac disease. Because depression has also been shown to be associated with increased mortality in these patients, it remains u ... Full text Link to item Cite

Zonisamide prevents olanzapine-associated hyperphagia, weight gain, and elevated blood glucose in rats.

Journal Article Neuropsychopharmacology · November 2008 Olanzapine (OLZ), one of the second-generation atypical antipsychotics (SGAs), has shown relative advantages in patient adherence and outcomes. However, OLZ has also been associated with a higher incidence of weight gain than most other SGAs. Excessive wei ... Full text Link to item Cite

Social support in older individuals: the role of the BDNF Val66Met polymorphism.

Journal Article Am J Med Genet B Neuropsychiatr Genet · October 5, 2008 Although often viewed as a purely environmental construct, perception of social support may be influenced by genetic factors. This study examined the relationship between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and social support ... Full text Link to item Cite

Frontal white matter anisotropy and antidepressant remission in late-life depression.

Journal Article PLoS One · September 24, 2008 INTRODUCTION: Neuroanatomic features associated with antidepressant treatment outcomes in older depressed individuals are not well established. This study used diffusion tensor imaging to examine frontal white matter structure in depressed subjects undergo ... Full text Link to item Cite

The vascular depression subtype: evidence of internal validity.

Journal Article Biol Psychiatry · September 15, 2008 BACKGROUND: Vascular depression has been proposed as a unique diagnostic subtype in late life, yet no study has evaluated whether the specified clinical features associated with the illness are jointly indicative of an underlying diagnostic class. METHODS: ... Full text Link to item Cite

Safety and efficacy of sertraline for depression in patients with CHF (SADHART-CHF): a randomized, double-blind, placebo-controlled trial of sertraline for major depression with congestive heart failure.

Journal Article Am Heart J · September 2008 BACKGROUND: Sertraline, a selective serotonin-reuptake inhibitor, has demonstrated substantial mood improvement in patients with post myocardial infarction or with unstable angina. The impact of sertraline on the prognosis and depression of patients with c ... Full text Link to item Cite

Hippocampal volumes and depression subtypes.

Journal Article Psychiatry Res · July 15, 2008 Studies of depression and hippocampal volume have yielded inconsistent results. This inconsistency could stem from the heterogeneity of depressive disorders. We conducted cross-sectional and longitudinal analyses of hippocampal volumes in atypical depressi ... Full text Link to item Cite

Prefrontal mechanisms for executive control over emotional distraction are altered in major depression.

Journal Article Psychiatry Res · July 15, 2008 A dysfunction in the interaction between executive function and mood regulation has been proposed as the pathophysiology of depression. However, few studies have investigated the alteration in brain systems related to executive control over emotional distr ... Full text Link to item Cite

Depressive state- and disease-related alterations in neural responses to affective and executive challenges in geriatric depression.

Journal Article Am J Psychiatry · July 2008 OBJECTIVE: Geriatric depression has been associated with a heterogeneous neuropathology. Identifying both depressive state-related and disease-related alterations in brain regions associated with emotion and cognitive function could provide useful diagnost ... Full text Link to item Cite

Age-dependent reduction of amygdala volume in bipolar disorder.

Journal Article Psychiatry Res · May 30, 2008 The amygdala is hypothesized to play a critical role in mood regulation, yet its involvement in bipolar disorder remains unclear. The aim of the present study was to compare measurements of amygdala volumes in a relatively large sample of bipolar disorder ... Full text Link to item Cite

Eszopiclone coadministered with escitalopram in patients with insomnia and comorbid generalized anxiety disorder.

Journal Article Arch Gen Psychiatry · May 2008 CONTEXT: Insomnia and generalized anxiety disorder (GAD) are prevalent disorders that may coexist. OBJECTIVE: To determine the efficacy of eszopiclone combined with escitalopram oxalate in treating insomnia comorbid with GAD. DESIGN: Double-blind, randomiz ... Full text Link to item Cite

The brain-derived neurotrophic factor VAL66MET polymorphism and cerebral white matter hyperintensities in late-life depression.

Journal Article Am J Geriatr Psychiatry · April 2008 OBJECTIVE: In animal models, brain-derived neurotrophic factor (BDNF) appears to protect against cerebral ischemia. The authors examined whether the BDNF Val66Met polymorphism, which affects BDNF distribution, was associated with greater volumes of hyperin ... Full text Link to item Cite

Hippocampus shape analysis and late-life depression.

Journal Article PLoS One · March 19, 2008 Major depression in the elderly is associated with brain structural changes and vascular lesions. Changes in the subcortical regions of the limbic system have also been noted. Studies examining hippocampus volumetric differences in depression have shown va ... Full text Open Access Link to item Cite

Antidepressant treatment and worsening white matter on serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health Study.

Journal Article Stroke · March 2008 BACKGROUND AND PURPOSE: In some studies, late life depression is associated with white matter lesions on MRI. The effect of different classes of antidepressants on progression of white matter lesions is unknown. Selective serotonergic reuptake inhibitors ( ... Full text Link to item Cite

Short/long heterozygotes at 5HTTLPR and white matter lesions in geriatric depression.

Journal Article Int J Geriatr Psychiatry · March 2008 OBJECTIVE: We examined the relationship between 5HTTLPR genotype and volume of magnetic resonance imaging (MRI) brain lesions. METHOD: We studied 217 older depressed patients and 141 individuals in the comparison group using a standard brain MRI protocol t ... Full text Link to item Cite

A global partnership in medical education between Duke University and the National University of Singapore.

Journal Article Acad Med · February 2008 Duke University and the National University of Singapore (NUS) have partnered to launch a new medical school that brings the American style of postbaccalaureate medical education to Asia. The new institution, called the Duke-NUS Graduate Medical School (GM ... Full text Link to item Cite

Aging, gender, and the elderly adult brain: an examination of analytical strategies.

Journal Article Neurobiol Aging · February 2008 We sought to examine the relations between age, gender and brain volumes in an elderly population; we also sought to examine ways of measuring these relations. Three sets of analyses were used: correlational analyses, in which correlations between independ ... Full text Link to item Cite

Patterns of pharmacotherapy and treatment response in elderly adults with bipolar disorder.

Journal Article Psychopharmacol Bull · 2008 BACKGROUND: Bipolar disorder is a difficult disease to treat because of its cycling nature, frequent residual symptoms, and poor compliance to treatment. Several guidelines have been proposed for treatment, but there is limited data on best treatment pract ... Link to item Cite

Response to jarvik's letter to the editor

Journal Article American Journal of Geriatric Psychiatry · January 1, 2008 Full text Cite

Towards a scientific taxonomy of depression.

Journal Article Dialogues Clin Neurosci · 2008 Many concepts have been introduced into the classification of depression, including manic-depressive/bipolar disorder depression, etc. Kraepelin's original concept of manic-depressive disorder has evolved into the concept of polarity, and bipolar and unipo ... Full text Link to item Cite

Orbitofrontal cortex volume in late life depression: influence of hyperintense lesions and genetic polymorphisms.

Journal Article Psychol Med · December 2007 BACKGROUND: Orbitofrontal cortex (OFC) volumetric differences have been reported in depression, but in relatively small samples. Factors associated with these differences are not well described. We examined OFC volumes in a large sample of elderly depresse ... Full text Link to item Cite

Predicting memory decline in normal elderly: genetics, MRI, and cognitive reserve.

Journal Article Neurobiol Aging · November 2007 Major predictors of Alzheimer's disease (AD) include apolipoprotein E (APOE)-epsilon4, hippocampal atrophy on magnetic resonance imaging (MRI), and memory dysfunction prior to diagnosis. We examined 159 normal elderly subjects with MRI and the California V ... Full text Link to item Cite

Metabolomic mapping of atypical antipsychotic effects in schizophrenia.

Journal Article Mol Psychiatry · October 2007 Schizophrenia is associated with impairments in neurotransmitter systems and changes in neuronal membrane phospholipids. Several atypical antipsychotic drugs induce weight gain and hypertriglyceridemia. To date, there has not been a comprehensive evaluatio ... Full text Link to item Cite

Prefrontal white matter lesions and prefrontal task impersistence in depressed and nondepressed elders.

Journal Article Neuropsychopharmacology · October 2007 Poor task persistence is often observed among depressed individuals, and may be associated with some of the same frontal regions that are involved in depression. The current study explored the association between white-matter lesion volume in prefrontal co ... Full text Link to item Cite

Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression.

Journal Article Am J Geriatr Psychiatry · October 2007 OBJECTIVE: The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with cognitive and neuroimaging changes. The authors examined the relationship between this polymorphism and depression in an elderly sample, hypothesizing tha ... Full text Link to item Cite

The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults.

Journal Article Psychiatry Res · July 15, 2007 We examined the relationship between COMT Val158Met genotype and temporal lobe volumes, including the caudate as a control region. Thirty-one healthy subjects completed 1.5T brain MRI and genotyping. After controlling for demographics, Val158 allele homozy ... Full text Link to item Cite

Neural correlates of promotion and prevention goal activation: an fMRI study using an idiographic approach.

Journal Article J Cogn Neurosci · July 2007 Regulatory focus theory [Higgins, E. T. Beyond pleasure and pain. American Psychologist, 52, 1280-1300, 1997] postulates two social-cognitive motivational systems, the promotion and prevention systems, for self-regulation of goal pursuit. However, the neur ... Full text Link to item Cite

Association of AGTR1 with 18-month treatment outcome in late-life depression.

Journal Article Am J Geriatr Psychiatry · July 2007 OBJECTIVE: Converging lines of evidence implicate vascular factors in late-life depression, and argue that late-life depression is a distinct entity among the mood disorders. The A1166C polymorphism in the angiotensin II receptor, vascular type 1 (AGTR1) g ... Full text Link to item Cite

Relationship between depressive symptoms and long-term mortality in patients with heart failure.

Journal Article Am Heart J · July 2007 BACKGROUND: Depression is prevalent in patients with heart failure (HF) and is associated with short-term poor prognosis. However, the long-term effect of depression and the use of self-administered depression evaluation on HF prognosis remained unknown. T ... Full text Link to item Cite

Response inhibition predicts poor antidepressant treatment response in very old depressed patients.

Journal Article Am J Geriatr Psychiatry · July 2007 OBJECTIVE: There have been mixed findings regarding the prognostic significance of age of onset, executive dysfunction, and hyperintensity burden on treatment outcome in late-life depression. METHODS: Growth curve models were fit to data from the only 8-we ... Full text Link to item Cite

Widespread effects of hyperintense lesions on cerebral white matter structure.

Journal Article AJR Am J Roentgenol · June 2007 OBJECTIVE: Hyperintense lesions are a common finding on neuroimaging and are associated not only with aging, medical illness, and some invasive medical procedures, but also with neurologic and psychiatric morbidity. We hypothesized that hyperintense lesion ... Full text Link to item Cite

A preliminary metabolomic analysis of older adults with and without depression.

Journal Article Int J Geriatr Psychiatry · May 2007 BACKGROUND: Metabolomics, the global science of biochemistry, is an emerging field that enables detection and quantification of small molecules involved in metabolic and signaling pathways. Metabolic signatures for disease and its treatment could provide v ... Full text Link to item Cite

Risk aversion among depressed older adults with obsessive compulsive personality disorder

Journal Article Cognitive Therapy and Research · April 1, 2007 Despite considerable research on depression in older adults, few studies have included individuals with personality disorders or have used laboratory tasks to examine behavioral correlates of depression among older adults. This study used the Bechara Gambl ... Full text Cite

Predicting antipsychotic use in children.

Journal Article Psychopharmacol Bull · 2007 UNLABELLED: Psychotropic medications are increasingly being used by children and adolescents. In an earlier report, we noted that boys were receiving atypical antipsychotics more frequently than were girls, (70% of the claims). Since diagnosis was not avai ... Link to item Cite

Structural integrity of the uncinate fasciculus in geriatric depression: Relationship with age of onset.

Journal Article Neuropsychiatr Dis Treat · 2007 BACKGROUND: The uncinate fasciculus connects limbic structures, such as the hippocampus and amygdala, with frontal regions. This study utilized diffusion tensor imaging to examine the structural integrity of the uncinate fasciculus in late-life depression. ... Link to item Cite

Prevalence of HIV infection in a general psychiatric outpatient population.

Journal Article Psychosomatics · 2007 The prevalence of human immunodeficiency virus (HIV) infection in the general psychiatric population is unknown. The authors conducted a retrospective review of all patients evaluated through the psychiatric outpatient clinics at Duke University Medical Ce ... Full text Link to item Cite

Concept of disease in geriatric psychiatry.

Journal Article Am J Geriatr Psychiatry · January 2007 The concept of disease in geriatric psychiatry has to keep up with the rapid expansion in knowledge about the putative etiology of various diseases of interest. This article reviews the new knowledge that has been acquired about dementia. The proposed clas ... Full text Link to item Cite

Revisiting monoamine oxidase inhibitors.

Journal Article J Clin Psychiatry · 2007 Monoamine oxidase inhibitors (MAOIs) were among the first class of agents introduced for the treatment of depression. However, they have fallen out of favor among clinicians over the years, due mostly to an unfavorable safety profile, the need for restrict ... Link to item Cite

Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression.

Journal Article Biol Psychiatry · December 15, 2006 BACKGROUND: The dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) are critical for mood regulation. Alterations in the white matter connections of these regions may impair their role in mood regulation and increase the risk of deve ... Full text Link to item Cite

Psychiatric disease in the twenty-first century: The case for subcortical ischemic depression.

Journal Article Biol Psychiatry · December 15, 2006 The current approach to psychiatric diagnoses involves identifying symptom clusters that fit a specific syndrome. Although this approach has facilitated the field's development, advances in genetics and neuroimaging raise the question of how causality may ... Full text Link to item Cite

Safety and efficacy of rivastigmine in adolescents with Down syndrome: a preliminary 20-week, open-label study.

Journal Article J Child Adolesc Psychopharmacol · December 2006 Individuals with Down syndrome (DS) exhibit a cholinergic deficiency similar to that found in Alzheimer's disease. Cholinesterase inhibitors, used to treat Alzheimer's disease, may improve cognitive function in individuals with DS. This is the first invest ... Full text Link to item Cite

White matter lesion volumes and caudate volumes in late-life depression.

Journal Article Int J Geriatr Psychiatry · December 2006 BACKGROUND: Decreased caudate volumes and increased white matter lesions (WMLs) are associated both with aging and late-life depression, but the relationship between the two is unclear. We examined the association between WML and caudate volume, hypothesiz ... Full text Link to item Cite

Differences in brain volumes among males and female hormone-therapy users and nonusers.

Journal Article Psychiatry Res · October 30, 2006 Numerous studies have shown gender differences in the brain volumes of elderly adults. Some evidence shows that higher estrogen levels may be neuroprotective, suggesting that hormone therapy (HT) may in part be responsible for these gender differences; how ... Full text Link to item Cite

SLITRK1 mutations in trichotillomania.

Journal Article Mol Psychiatry · October 2006 Full text Link to item Cite

Lobar distribution of lesion volumes in late-life depression: the Biomedical Informatics Research Network (BIRN).

Journal Article Neuropsychopharmacology · July 2006 White matter hyperintense lesions on T2-weighted images are associated with late-life depression. Little work has been carried out examining differences in lesion location between elderly individuals with and without depression. In contrast to previous stu ... Full text Link to item Cite

Prognosis of patients taking selective serotonin reuptake inhibitors before coronary artery bypass grafting.

Journal Article Am J Cardiol · July 1, 2006 Depression is increasingly recognized as an independent prognostic risk factor in patients with coronary artery disease and coronary artery bypass grafting (CABG). The use of selective serotonin reuptake inhibitors (SSRIs) for depression in patients with c ... Full text Link to item Cite

The medical burden of depression

Conference INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY · July 1, 2006 Link to item Cite

White matter hyperintensity progression and late-life depression outcomes

Conference INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY · July 1, 2006 Link to item Cite

The relation of free plasma tryptophan to anger, hostility, and aggression in a nonpatient sample of adult men and women.

Journal Article Ann Behav Med · June 2006 BACKGROUND: Dysregulation of central nervous system serotonergic (5-HT) activity is implicated in behavioral states and psychological traits associated with depression and aggression, with some studies suggesting possible gender-related differences. PURPOS ... Full text Link to item Cite

Perspectives on depression, mild cognitive impairment, and cognitive decline.

Journal Article Arch Gen Psychiatry · February 2006 CONTEXT: The public health implications of depression and cognitive impairment in late life are enormous. Cognitive impairment and late-life depression are associated with increased risk for subsequent dementia; however, investigations of these phenomena a ... Full text Link to item Cite

Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomised phase III trial.

Journal Article Lancet · January 7, 2006 BACKGROUND: Psoriasis has substantial psychological and emotional effects. We assessed the effect of etanercept, an effective treatment for the clinical symptoms of psoriasis, on fatigue and symptoms of depression associated with the condition. METHODS: 61 ... Full text Link to item Cite

Assessment and treatment of depression in patients with cardiovascular disease: National Heart, Lung, and Blood Institute Working Group Report.

Journal Article Psychosom Med · 2006 OBJECTIVE: The National Heart, Lung, and Blood Institute convened an interdisciplinary working group of experts to develop recommendations for the assessment and treatment of depression in patients with coronary heart disease (CHD). METHOD: Consensus of ex ... Full text Link to item Cite

A randomized controlled trial of paroxetine for noncardiac chest pain.

Journal Article Psychopharmacol Bull · 2006 Noncardiac chest pain occurs frequently in medical practice and is often difficult to treat. We conducted a randomized double-blind, placebo-controlled, 8-week trial of paroxetine in 50 patients with noncardiac chest pain. None of the patients met criteria ... Link to item Cite

What constitutes clinical evidence for neuroprotection in Alzheimer disease: support for the cholinesterase inhibitors?

Journal Article Alzheimer Dis Assoc Disord · 2006 The progression of Alzheimer disease (AD) corresponds to a prolonged course of neuronal loss in the cerebral cortex. Strategies aimed at reducing the rates of neuronal loss are therefore particularly important. The clinical measures to evaluate the disease ... Full text Link to item Cite

Suicide risk analysis among patients assigned to psychotropics and placebo.

Journal Article Psychopharmacol Bull · 2006 Based on available data, it is unclear if the suicide risk is significantly different among clinical trial patients assigned to psychotropics compared with patients assigned to placebo, among patients with various psychiatric diagnoses. This study was to i ... Link to item Cite

Brain morphometry, T2-weighted hyperintensities, and IQ in children with neurofibromatosis type 1.

Journal Article Arch Neurol · December 2005 BACKGROUND: Larger gray matter (GM) volume in healthy children is correlated with higher IQ. Children with neurofibromatosis type 1 (NF1) have larger brains, their magnetic resonance images frequently show T2-weighted hyperintensities, and their IQs are lo ... Full text Link to item Cite

Cortical white matter microstructural abnormalities in bipolar disorder.

Journal Article Neuropsychopharmacology · December 2005 This article reports on preliminary findings describing microstructural abnormalities in the white matter of cortical areas thought to be associated with bipolar disorder. In all, 14 patients with bipolar disorder and 21 nonpsychiatrically ill control subj ... Full text Link to item Cite

Residual symptoms in older patients treated for major depression.

Journal Article Int J Geriatr Psychiatry · December 2005 OBJECTIVE: The purpose of this study was to identify residual symptoms in a sample of older adults treated for major depression and compare individual symptoms present at baseline with those at three months by remission status. METHODS: The sample was comp ... Full text Link to item Cite

Psychiatric disease in the genomic era: rational approach.

Journal Article Mol Psychiatry · November 2005 Although the introduction of explicit diagnostic criteria and rule-based classifications, such as Research Diagnostic Criteria, Diagnostic and Statistical Manual Ed 3 and Ed 4, has dramatically influenced teaching and research psychiatric practice, it has ... Full text Link to item Cite

Effects of paroxetine and venlafaxine XR on heart rate variability in depression.

Journal Article J Clin Psychopharmacol · October 2005 Depressed patients may exhibit reduced heart rate variability (HRV), and antidepressants which block norepinephrine uptake may also lower HRV. This study compared paroxetine (PAR) and venlafaxine XR (VEN-XR) on HRV. Outpatients were randomly assigned to do ... Full text Link to item Cite

Prominent reduction in pyramidal neurons density in the orbitofrontal cortex of elderly depressed patients.

Journal Article Biol Psychiatry · August 15, 2005 BACKGROUND: Elderly depressed patients have more vascular hyperintensities in frontal white matter and basal ganglia than elderly control subjects. Cell pathology that might be related to increased vascular hyperintensities has not been examined. METHODS: ... Full text Link to item Cite

Mood disorders in the medically ill: scientific review and recommendations.

Journal Article Biol Psychiatry · August 1, 2005 OBJECTIVE: The purpose of this review is to assess the relationship between mood disorders and development, course, and associated morbidity and mortality of selected medical illnesses, review evidence for treatment, and determine needs in clinical practic ... Full text Link to item Cite

Treatment of depression in the medically ill.

Journal Article J Clin Psychopharmacol · August 2005 Most studies on treatment methods in elderly depressive patients have included primarily patients in good physical health, excluding medical comorbidity, despite the fact that depression with medical comorbidity is the norm rather than the exception. In ad ... Full text Link to item Cite

Effects of antidepressant medication on morbidity and mortality in depressed patients after myocardial infarction.

Journal Article Arch Gen Psychiatry · July 2005 BACKGROUND: Depression after myocardial infarction (MI) is associated with higher morbidity and mortality. Although antidepressants are effective in reducing depression, their use in patients with cardiovascular disease remains controversial. OBJECTIVE: To ... Full text Link to item Cite

Through the looking glass: risk perception.

Journal Article Biol Psychiatry · June 15, 2005 Full text Link to item Cite

Atypical antipsychotic drugs and diabetes mellitus in a large outpatient population: a retrospective cohort study.

Journal Article Pharmacoepidemiol Drug Saf · June 2005 PURPOSE: Previous research has suggested an association between use of atypical antipsychotics and onset of diabetes mellitus. We sought to compare the incidence of new onset diabetes among patients receiving atypical antipsychotics, traditional antipsycho ... Full text Link to item Cite

Relationship between release of platelet/endothelial biomarkers and plasma levels of sertraline and N-desmethylsertraline in acute coronary syndrome patients receiving SSRI treatment for depression.

Journal Article Am J Psychiatry · June 2005 OBJECTIVE: In a platelet/endothelial biomarker substudy of the Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART), the authors sought to determine whether plasma levels of sertraline and its primary metabolite N-desmethylsertraline affect th ... Full text Link to item Cite

Hyperforin plasma level as a marker of treatment adherence in the National Institutes of Health Hypericum Depression Trial.

Journal Article J Clin Psychopharmacol · June 2005 BACKGROUND: A previously reported clinical trial of Hypericum perforatum (St John's wort) in depression did not demonstrate efficacy. We assessed treatment adherence by measuring plasma hyperforin and evaluated the possible impact of adherence on study res ... Full text Link to item Cite

Greater MRI lesion volumes in elderly depressed subjects than in control subjects.

Journal Article Psychiatry Res · May 30, 2005 Hyperintense lesions in both white matter and gray matter on T2-weighted magnetic resonance imaging (MRI) are associated with late-life depression. This large study examined differences in gray and white matter lesion volumes on brain MRI between 253 elder ... Full text Link to item Cite

Influence of serotonin transporter promoter region polymorphisms on hippocampal volumes in late-life depression.

Journal Article Arch Gen Psychiatry · May 2005 CONTEXT: Polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR) influence transcription and may play a role in the pathogenesis and course of depression. Recent research demonstrates that specific polymorphisms may be associated ... Full text Link to item Cite

The case for practical clinical trials in psychiatry.

Journal Article Am J Psychiatry · May 2005 OBJECTIVE: Clinical trials in psychiatry frequently fail to maximize clinical utility for practicing clinicians, or, stated differently, available evidence is not perceived by clinicians (and other decision makers) as sufficiently relevant to clinical prac ... Full text Link to item Cite

Magnitude of placebo response and drug-placebo differences across psychiatric disorders.

Journal Article Psychol Med · May 2005 BACKGROUND: Placebo response, drug response, and drug-placebo differences appear to vary among psychiatric conditions. METHOD: We evaluated the Food and Drug Administration (FDA) Summary Basis of Approval (SBA) reports to compare the magnitude of placebo r ... Full text Link to item Cite

Prevalence of atypical antipsychotic drug use among commercially insured youths in the United States.

Journal Article Arch Pediatr Adolesc Med · April 2005 BACKGROUND: Use of atypical antipsychotic medications in pediatric populations is increasing. Although previous studies have presented data by age or sex, none has documented sex-specific prevalence by age group. OBJECTIVE: To estimate the 1-year prevalenc ... Full text Link to item Cite

Biological and social predictors of long-term geriatric depression outcome.

Journal Article Int Psychogeriatr · March 2005 OBJECTIVE: In this study, we examined 204 older depressed individuals for up to 64 months to determine factors related to depression outcome. We hypothesized that both presence of vascular brain lesions seen on baseline magnetic resonance imaging (MRI) sca ... Full text Link to item Cite

Comparing the effects of antidepressants: consensus guidelines for evaluating quantitative reviews of antidepressant efficacy.

Journal Article Neuropsychopharmacology · March 2005 With increasing numbers of treatment options available for patients with major depression over the last decade and the growing body of evidence describing their efficacy and safety, clinicians often find it difficult to determine the best and most appropri ... Full text Link to item Cite

Medical comorbidity in a bipolar outpatient clinical population.

Journal Article Neuropsychopharmacology · February 2005 The presence of medical illnesses among inpatients with bipolar disorder is known to complicate treatment and lengthen hospital stay. However, except for a few specific diseases, little is known about prevalence of medical illnesses in bipolar outpatients ... Full text Link to item Cite

Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression.

Journal Article Neuron · January 6, 2005 Dysregulation of central serotonin neurotransmission has been widely suspected as an important contributor to major depression. Here, we identify a (G1463A) single nucleotide polymorphism (SNP) in the rate-limiting enzyme of neuronal serotonin synthesis, h ... Full text Link to item Cite

Psychiatric and psychosocial risks in acutely decompensated chronic heart failure patients

Chapter · January 1, 2005 Chronic heart failure is the end stage of many diseases of the heart and has a major negative impact on the American public. While mortality from coronary artery disease (CAD) is declining, the incidence of chronic heart failure is increasing. More than 50 ... Full text Cite

Psychiatric and medical comorbidities of bipolar disorder.

Journal Article Psychosom Med · 2005 OBJECTIVES: This review summarizes the literature on psychiatric and medical comorbidities in bipolar disorder. The coexistence of other Axis I disorders with bipolar disorder complicates psychiatric diagnosis and treatment. Conversely, symptom overlap in ... Full text Link to item Cite

Neuroimaging and frontal-subcortical circuitry in late-fife major depression

Conference INTERNATIONAL PSYCHOGERIATRICS · January 1, 2005 Link to item Cite

Prefrontal neuropsychological predictors of treatment remission in late-life depression.

Journal Article Neuropsychopharmacology · December 2004 Recent studies suggest that neuropsychological measures involving the prefrontal cortex are associated with treatment remission in late-life depression. To further explore this issue, we studied the neuropsychological performance of 110 depressed individua ... Full text Link to item Cite

Is there a definition of remission in late-life depression that predicts later relapse?

Journal Article Neuropsychopharmacology · December 2004 Remission of depressive symptoms is the goal of all antidepressant therapy. Rating scales define remission in clinical trials, but it is unclear how well these definitions predict risk of later relapse. We measured the sensitivity and specificity of a rang ... Full text Link to item Cite

Prognostic value of anxiety and depression in patients with chronic heart failure.

Journal Article Circulation · November 30, 2004 BACKGROUND: Anxiety is often present with depression and may be one of its manifestations. Although the adverse effects of depression in patients with chronic heart failure (CHF) have been well studied, the relation between anxiety and CHF prognosis has no ... Full text Link to item Cite

Research design features and patient characteristics associated with the outcome of antidepressant clinical trials.

Journal Article Am J Psychiatry · November 2004 OBJECTIVE: The authors examined which, if any, research design features and patient characteristics would significantly differ between successful and unsuccessful antidepressant trials. METHOD: Clinical trial data were reviewed for nine antidepressants app ... Full text Link to item Cite

Antidepressant pharmacotherapy in the treatment of depression in the very old: a randomized, placebo-controlled trial.

Journal Article Am J Psychiatry · November 2004 OBJECTIVE: This study determined the efficacy of antidepressant medication for the treatment of depression in the "old-old." METHOD: This randomized 8-week medication trial compared citalopram, 10-40 mg/day, to placebo in the treatment of patients 75 and o ... Full text Link to item Cite

Enhanced expression of cytokines and chemokines by blood monocytes to in vitro lipopolysaccharide stimulation are associated with hostility and severity of depressive symptoms in healthy women.

Journal Article Psychoneuroendocrinology · October 2004 The current study investigated the relation of hostility and severity of depressive symptoms, separately and jointly, to the capacity of blood monocytes to secrete an array of cytokines when stimulated by bacterial lipopolysaccharide (LPS). Subjects were 4 ... Full text Link to item Cite

Medical comorbidity in late-life depression.

Journal Article Int J Geriatr Psychiatry · October 2004 OBJECTIVES: Medical comorbidity is common in elderly patients with depression, however the difference between depressed and non-depressed elderly populations is not well established. Additionally, differences between subgroups of depressed populations, inc ... Full text Link to item Cite

The association between depression and chronic kidney disease and mortality among patients hospitalized with congestive heart failure.

Journal Article Am J Kidney Dis · August 2004 BACKGROUND: The point prevalence of depression and its relationship to poor outcomes among patients with chronic kidney disease (CKD) has not been fully characterized. METHODS: We performed a secondary analysis of a prospective cohort of 374 patients admit ... Full text Link to item Cite

Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter.

Journal Article Am J Psychiatry · July 2004 OBJECTIVE: The purpose of this study was to determine whether microstructural abnormalities in the white matter of the dorsolateral prefrontal cortex are associated with late-life depression. METHOD: Seventeen elderly depressed subjects were compared with ... Full text Link to item Cite

Should selective serotonin reuptake inhibitors be prescribed to all patients with ischemic heart disease?

Journal Article Curr Psychiatry Rep · June 2004 Recent studies have uncovered more and more evidence demonstrating the adverse relationship between depression and ischemic heart disease. One of the most significant mechanisms that may explain the adverse relationship is the increased platelet activity, ... Full text Link to item Cite

Medical comorbidity: Special patient populations

Conference INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY · June 1, 2004 Link to item Cite

The Child and Adolescent Psychiatry Trials Network (CAPTN).

Journal Article J Am Acad Child Adolesc Psychiatry · May 2004 OBJECTIVE: The current generation of clinical trials in pediatric psychiatry often fails to maximize clinical utility for practicing clinicians, thereby diluting its impact. METHOD: To attain maximum clinical relevance and acceptability, the Child and Adol ... Full text Link to item Cite

Dr. Schneider and Colleagues Reply

Journal Article American Journal of Psychiatry · April 1, 2004 Full text Cite

Clinical characteristics of magnetic resonance imaging-defined subcortical ischemic depression.

Journal Article Biol Psychiatry · February 15, 2004 BACKGROUND: There is a substantial body of research supporting the vascular depression hypothesis of late-life depression. To update this hypothesis so it incorporates recent research, we propose that the term subcortical ischemic vascular depression may b ... Full text Link to item Cite

Caudate volume measurement in older adults with bipolar disorder.

Journal Article Int J Geriatr Psychiatry · February 2004 BACKGROUND: Decreased caudate volumes have been noted in unipolar depressed subjects, especially in the elderly and those with cognitive impairment. No differences have been noted in initial studies of multi-aged bipolar subjects; however, this region has ... Full text Link to item Cite

Diffusion tensor imaging: background, potential, and utility in psychiatric research.

Journal Article Biol Psychiatry · February 1, 2004 Diffusion tensor imaging is a variation of magnetic resonance imaging that measures the diffusion of water in tissues. This can help measure and quantify a tissue's orientation and structure, making it an ideal tool for examining cerebral white matter and ... Full text Link to item Cite

Hippocampal volume measurement in older adults with bipolar disorder.

Journal Article Am J Geriatr Psychiatry · 2004 OBJECTIVE: Decreased hippocampal volumes have been noted in unipolar depressed subjects, especially in elderly patients and those with cognitive impairment. Initial studies of mixed-aged bipolar subjects and controls have had conflicting findings, with mos ... Full text Link to item Cite

A randomized, placebo-controlled study of the efficacy and safety of sertraline in the treatment of the behavioral manifestations of Alzheimer's disease in outpatients treated with donepezil.

Journal Article Int J Geriatr Psychiatry · January 2004 OBJECTIVE: To examine the safety and efficacy of sertraline augmentation therapy in the treatment of behavioral manifestations of Alzheimer's disease (AD) in outpatients treated with donepezil. METHODS AND MATERIALS: Patients with probable or possible AD, ... Full text Link to item Cite

Estimating suicidality as an outcome measure in clinical trials of suicide in schizophrenia.

Journal Article Schizophr Bull · 2004 A Suicide Monitoring Board (SMB) evaluated putative events of suicidal behavior to determine whether they should be counted as outcome data (endpoints) in the International Suicide Prevention Trial (InterSePT) study. The InterSePT study compared clozapine ... Full text Link to item Cite

The international suicide prevention trial (interSePT): rationale and design of a trial comparing the relative ability of clozapine and olanzapine to reduce suicidal behavior in schizophrenia and schizoaffective patients.

Journal Article Schizophr Bull · 2004 Suicidal behavior in patients with psychotic disorders represents a seriously undertreated life-threatening condition. The International Suicide Prevention Trial (InterSePT) is the first large-scale, prospective study designed to evaluate the potential of ... Full text Link to item Cite

Diagnostic criteria for Depression of Alzheimer disease (DAD)

Journal Article Research and Practice in Alzheimer's Disease · December 1, 2003 This chapter focuses on the development of diagnostic criteria for Depression of Alzheimer disease. Depression of Alzheimer's disease is similar to major depression, but relies less on verbal reporting, requires fewer symptoms, and includes irritability as ... Cite

Does antidepressant therapy improve cognition in elderly depressed patients?

Journal Article J Gerontol A Biol Sci Med Sci · December 2003 OBJECTIVES: To analyze the effects of antidepressants on cognitive functioning in elderly depression. METHODS: Data were pooled for elderly participants with major depression from two double-blind 12-week studies (n = 444) comparing sertraline to fluoxetin ... Full text Link to item Cite

Left orbital frontal cortex volume and performance on the benton visual retention test in older depressives and controls.

Journal Article Neuropsychopharmacology · December 2003 Changes within the prefrontal cortex (PFC) have been associated with both mood disorders and with specific impairments in cognitive testing. The left PFC has been implicated in relational processing, that is, binding different pieces of information. We hyp ... Full text Link to item Cite

Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease.

Journal Article Am J Psychiatry · November 2003 OBJECTIVE: The authors examined the effect of the acetylcholinesterase inhibitor donepezil on magnetic resonance markers of neurodegeneration in Alzheimer's disease. METHOD: In this randomized, double-blind, placebo-controlled pilot study, 67 patients with ... Full text Link to item Cite

White matter hyperintensity progression and late-life depression outcomes.

Journal Article Arch Gen Psychiatry · November 2003 CONTEXT: White matter hyperintensities (WMHs) are bright foci seen in the parenchyma of the brain on T2-weighted cranial magnetic resonance imaging (MRI) scans and are associated with geriatric depression. Because they are associated with age, they should ... Full text Link to item Cite

Focal and lateralized subcortical abnormalities in unipolar major depressive disorder: an automated multivoxel proton magnetic resonance spectroscopy study.

Journal Article Biol Psychiatry · October 1, 2003 BACKGROUND: The results of prior proton magnetic resonance spectroscopy ((1)H-MRS) studies in unipolar major depressive disorder (MDD) evaluating choline (Cho)/creatine (Cr) and N-acetyl-L-aspartate (NAA)/Cr ratios are mixed. These single-voxel or one-dime ... Full text Link to item Cite

Subcortical lesion severity and orbitofrontal cortex volume in geriatric depression.

Journal Article Biol Psychiatry · September 1, 2003 Previous studies have shown a reduction of orbital frontal cortex volume and an increase in magnetic resonance imaging signal hyperintensities in geriatric depression. We aimed to assess the relationship between subcortical gray- and deep white-matter lesi ... Full text Link to item Cite

Enhanced platelet/endothelial activation in depressed patients with acute coronary syndromes: evidence from recent clinical trials.

Journal Article Blood Coagul Fibrinolysis · September 2003 Platelets play a key role in the progression of acute coronary syndromes (ACS). Clinical depression alone is also associated with enhanced platelet activation. The purpose of this study was to compare concentrations of established biomarkers of enhanced pl ... Full text Link to item Cite

Platelet/endothelial biomarkers in depressed patients treated with the selective serotonin reuptake inhibitor sertraline after acute coronary events: the Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy.

Journal Article Circulation · August 26, 2003 BACKGROUND: Depression after acute coronary syndromes (ACSs) has been identified as an independent risk factor for subsequent cardiac death. Enhanced platelet activation has been hypothesized to represent 1 of the mechanisms underlying this association. Se ... Full text Link to item Cite

Predicting suicidal risk in schizophrenic and schizoaffective patients in a prospective two-year trial.

Journal Article Biol Psychiatry · August 15, 2003 BACKGROUND: Enhanced ability to reliably identify risk factors for suicidal behavior permits more focused decisions concerning treatment interventions and support services, with potential reduction in lives lost to suicide. METHODS: This study followed 980 ... Full text Link to item Cite

Serial MR imaging of volumes of hyperintense white matter lesions in elderly patients: correlation with vascular risk factors.

Journal Article AJR Am J Roentgenol · August 2003 OBJECTIVE: The purpose of the study was to examine change in volume of hyperintense white matter lesions in a cohort of community-dwelling elderly subjects without neuropsychiatric disease. SUBJECTS AND METHODS. One hundred seventeen volunteers underwent b ... Full text Link to item Cite

Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late life.

Journal Article Arch Gen Psychiatry · July 2003 OBJECTIVES: To review progress made during the past decade in late-life mood disorders and to identify areas of unmet need in health care delivery and research. PARTICIPANTS: The Consensus Development Panel consisted of experts in late-life mood disorders, ... Full text Link to item Cite

An 8-week multicenter, parallel-group, double-blind, placebo-controlled study of sertraline in elderly outpatients with major depression.

Journal Article Am J Psychiatry · July 2003 OBJECTIVE: There have been few placebo-controlled trials of selective serotonin reuptake inhibitors for depressed elderly patients. This placebo-controlled study of sertraline was designed to confirm the results of non-placebo-controlled trials. METHOD: Th ... Full text Link to item Cite

Broken heart: depression in cardiovascular disease.

Journal Article Dialogues Clin Neurosci · June 2003 Heart disease and depression are among the most common diseases seen in developed countries. The relation-ship between heart disease and depression has been the subject of both popular interest and scientific research. Sadness is often portrayed as a feeli ... Full text Link to item Cite

Localization of age-associated white matter hyperintensities in late-life depression.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · May 2003 OBJECTIVE: Deep white matter hyperintense lesions are associated with advanced age and late-life depression. The authors examined where age-related cerebral lesions occurred in elderly depressed and healthy control subjects. METHODS: Eighty-seven depressed ... Full text Link to item Cite

Comorbidity and depression treatment.

Conference Biol Psychiatry · April 15, 2003 Comorbidity is common among patients with major depression, but in most instances it may be of little relevance. Nonetheless, it is a complex issue because of its relation to treatment response, and few studies have attempted to address this. Most have exa ... Full text Link to item Cite

Zonisamide for weight loss in obese adults: a randomized controlled trial.

Journal Article JAMA · April 9, 2003 CONTEXT: Zonisamide is a marketed antiepileptic drug that has serotonergic and dopaminergic activity in addition to blockade of sodium and calcium channels. Weight loss was an adverse effect associated with zonisamide treatment in epilepsy clinical trials. ... Full text Link to item Cite

Social support in elderly patients with bipolar disorder.

Journal Article Bipolar Disord · February 2003 OBJECTIVE: The role of social support in bipolar disorder is poorly understood. It is known that young and middle-aged patients with impaired social support are more likely to be treatment resistant and have increased hospitalization. However, the role of ... Full text Link to item Cite

Donepezil for the treatment of language deficits in adults with Down syndrome: a preliminary 24-week open trial.

Journal Article Am J Med Genet A · January 15, 2003 At present, there is no proven pharmacologic treatment for cognitive or language impairments in Down syndrome (DS). Cholinergic deficits have been documented in DS and linked to cognitive deficits. This study is a 24-week open-label clinical trial of donep ... Full text Link to item Cite

Smaller orbital frontal cortex volumes associated with functional disability in depressed elders.

Journal Article Biol Psychiatry · January 15, 2003 BACKGROUND: Depression is associated with significant functional impairment. Recent evidence has linked the orbital frontal cortex (OFC) with depression. We examined the relationship between OFC volumes in older subjects and impairment in the basic (BADL) ... Full text Link to item Cite

MRI lesion severity and mortality in geriatric depression.

Journal Article Am J Geriatr Psychiatry · 2003 OBJECTIVE: The authors correlated magnetic resonance imaging (MRI) lesion severity and mortality among depressed elderly patients. METHOD: They examined the association of mortality and deep white-matter hyperintensity (DWMH), periventricular hyperintensit ... Full text Link to item Cite

Evidence-based mental health use of anticonvulsants during pregnancy.

Journal Article Psychopharmacol Bull · 2003 There are many pertinent issues surrounding the treatment of bipolar disorder during pregnancy. Unfortunately, while there are numerous observational reports in the literature, there is not a lot of information concerning the safety and efficacy of particu ... Link to item Cite

Evidence for the treatment of borderline personality disorder.

Journal Article Psychopharmacol Bull · 2003 The treatment of patients with borderline personality disorder (BPD) is notoriously difficult. Psychotherapeutic and pharmacological strategies have been investigated, and a few have shown promise. Dialectical behavior therapy (DBT) may be helpful in decre ... Link to item Cite

Partial response as a predictor of outcome in geriatric depression.

Journal Article Am J Geriatr Psychiatry · 2003 OBJECTIVE: Although geriatric depression generally responds to treatment, patients are often left with residual symptoms after acute treatment. Data are lacking on the eventual outcomes of individuals who are partial responders or poor responders to initia ... Link to item Cite

Cholesterol-lowering medication and relapse of depression.

Journal Article Psychopharmacol Bull · 2003 This study sought to examine the effects of taking cholesterol-lowering medication on outcomes of depression among older depressed adults. 243 elderly depressed patients were treated using an antidepressant algorithm by a geriatric psychiatrist who adminis ... Link to item Cite

Provisional diagnostic criteria for depression of Alzheimer's disease: description and review.

Journal Article Expert Rev Neurother · January 2003 This review centers on the development of diagnostic criteria for depression of Alzheimer's disease. It describes: risk-factors and neurobiological correlates, epidemiology, clinical characteristics and course, assessment, treatment, economics, a descripti ... Full text Link to item Cite

The relation of severity of depressive symptoms to monocyte-associated proinflammatory cytokines and chemokines in apparently healthy men.

Journal Article Psychosom Med · 2003 OBJECTIVE: We examined the relation of severity of depressive symptoms to lipopolysaccharide-stimulated expression of monocyte-associated proinflammatory cytokines and chemokines in 53 nonsmoking, healthy men. METHODS: Assessments of cytokine and chemokine ... Full text Link to item Cite

Effect of bupropion SR on specific symptom clusters of depression: analysis of the 31-item Hamilton Rating Scale for depression.

Journal Article Psychopharmacol Bull · 2003 Principal component (PC) analysis is a statistical technique that has been used to identify core depression symptoms on the Hamilton Rating Scale for Depression (HAM-D). PC analysis is also a useful method to identify unidimensional scales of the HAM-D tha ... Link to item Cite

Vascular mechanisms and late life depression

Conference INTERNATIONAL PSYCHOGERIATRICS · January 1, 2003 Link to item Cite

Evidence-based decision-making in psychopharmacology.

Journal Article Psychopharmacol Bull · 2003 hen evaluating patients and making treatment decisions, physicians do not always have all the information necessary and may have to make judgments using limited information. This judgment is often intuitive in nature. The processes by which these judgments ... Link to item Cite

Evidence-based practice: how to evaluate what you read.

Journal Article Psychopharmacol Bull · 2003 Systematic reviews and meta-analysis are affected by the studies that are included or excluded. A number of biases are common including excluding unpublished data, non English language publications, and non indexed articles. In addition there can be a diff ... Link to item Cite

Clozapine treatment for suicidality in schizophrenia: International Suicide Prevention Trial (InterSePT).

Journal Article Arch Gen Psychiatry · January 2003 BACKGROUND: Approximately 50% of patients with schizophrenia or schizoaffective disorder attempt suicide, and approximately 10% die of suicide. Study results suggest that clozapine therapy significantly reduces suicidal behavior in these patients. METHODS: ... Full text Link to item Cite

MRI subcortical hyperintensities in old and very old depressed outpatients: the important role of age in late-life depression.

Conference J Neurol Sci · November 15, 2002 OBJECTIVE: There is increasing evidence that cerebrovascular factors play a key role in the etiology of late-life depression. This study examined the severity of subcortical hyperintensities (SH) and the relationship between SH and depression characteristi ... Full text Link to item Cite

Exercise therapy for depression in middle-aged and older adults: predictors of early dropout and treatment failure.

Journal Article Health Psychol · November 2002 Psychosocial factors predicting treatment dropout or failure to benefit from treatment were identified in a randomized trial of exercise therapy and pharmacotherapy for major depression. One hundred fifty-six men and women over age 50 diagnosed with major ... Link to item Cite

Comorbidity of depression with other medical diseases in the elderly.

Journal Article Biol Psychiatry · September 15, 2002 A major factor in the context of evaluating depression in the elderly is the role of medical problems. With aging there is a rapid increase in the prevalence of a number of medical disorders, including cancer, heart disease, Parkinson's disease, Alzheimer' ... Full text Link to item Cite

Comorbidity of late life depression: an opportunity for research on mechanisms and treatment.

Journal Article Biol Psychiatry · September 15, 2002 Late life depression principally affects individuals with other medical and psychosocial problems, including cognitive dysfunction, disability, medical illnesses, and social isolation. The clinical associations of late life depression have guided the devel ... Full text Link to item Cite

Development of a semi-automated method for quantification of MRI gray and white matter lesions in geriatric subjects.

Journal Article Psychiatry Res · August 20, 2002 Brain magnetic resonance imaging (MRI) allows for quantitative assessment of hyperintense foci, which are seen with aging and various diseases. These foci, considered to represent lesions, are important in the study of various psychiatric illnesses, includ ... Full text Link to item Cite

Sertraline treatment of major depression in patients with acute MI or unstable angina.

Journal Article JAMA · August 14, 2002 CONTEXT: Major depressive disorder (MDD) occurs in 15% to 23% of patients with acute coronary syndromes and constitutes an independent risk factor for morbidity and mortality. However, no published evidence exists that antidepressant drugs are safe or effi ... Full text Link to item Cite

Investigation of Notch3 as a candidate gene for bipolar disorder using brain hyperintensities as an endophenotype.

Journal Article Am J Med Genet · August 8, 2002 The purpose of the study was to consider MRI hyperintensities as a potential endophenotype for bipolar disorder (BPD) and to investigate Notch3 (CADASIL) as a candidate gene for BPD. MRI scans were performed on 21 members of a family with a high incidence ... Full text Link to item Cite

Anatomic location and laterality of MRI signal hyperintensities in late-life depression.

Journal Article J Psychosom Res · August 2002 OBJECTIVES: Evidence is mounting linking cerebrovascular disease with the development of major depression in the elderly. Lesions in both white and gray matter have been associated with geriatric depression. In addition, the literature on poststroke depres ... Full text Link to item Cite

Biological risk factors in late life depression.

Journal Article Biol Psychiatry · August 1, 2002 A number of biological risk factors have been tentatively identified for unipolar and bipolar disorder in the elderly. The list includes genetic factors as well as medical illness in general and vascular disease in particular. Most of these risk factors ha ... Full text Link to item Cite

MR signal intensity of gray matter/white matter contrast and intracranial fat: effects of age and sex.

Journal Article Psychiatry Res · July 1, 2002 Signal intensity (SI) values of gray- and white-matter brain regions of interest (ROIs) were obtained from T(2)- and proton density-weighted magnetic resonance (MR) images of 58 normal subjects aged 22-82 years (31 females, 52.3+/-18.8 years; 27 males, 54. ... Full text Link to item Cite

An application of the revised CONSORT standards to FDA summary reports of recently approved antidepressants and antipsychotics.

Journal Article Biol Psychiatry · July 1, 2002 BACKGROUND: Recent years have seen the introduction of many antidepressants and antipsychotics. Typically, efficacy of these agents is based on published positive clinical trials; however, the Food and Drug Administration (FDA) compiles summary reports of ... Full text Link to item Cite

Cerebrovascular disease and evolution of depressive symptoms in the cardiovascular health study.

Journal Article Stroke · June 2002 BACKGROUND AND PURPOSE: Previous studies have reported an association between cerebrovascular disease and depressive symptoms. The Cardiovascular Health Study (CHS) provides an opportunity to examine the relationship between vascular brain pathology seen o ... Full text Link to item Cite

Long-term effects of rivastigmine in moderately severe Alzheimer's disease: does early initiation of therapy offer sustained benefits?

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · May 2002 Goals of the study included evaluating the long-term efficacy of rivastigmine in Alzheimer's disease (AD) patient categories stratified by baseline dementia severity, and post hoc investigation of particular benefits of early initiation of rivastigmine tre ... Full text Link to item Cite

Substance P (NK-1 receptor) antagonists in major depression

Conference BIOLOGICAL PSYCHIATRY · April 15, 2002 Link to item Cite

Effect of Hypericum perforatum (St John's wort) in major depressive disorder: a randomized controlled trial.

Journal Article JAMA · April 10, 2002 CONTEXT: Extracts of Hypericum perforatum (St John's wort) are widely used for the treatment of depression of varying severity. Their efficacy in major depressive disorder, however, has not been conclusively demonstrated. OBJECTIVE: To test the efficacy an ... Full text Link to item Cite

Volumetric brain imaging findings in mood disorders.

Journal Article Bipolar Disord · April 2002 Volumetric neuroimaging is increasingly being used by researchers of affective disorders to assess potential involvement of different brain structures in mood regulation and to test neuroanatomic models of mood disorders. In unipolar depression, findings s ... Full text Link to item Cite

National Depressive and Manic-Depressive Association consensus statement on the use of placebo in clinical trials of mood disorders.

Journal Article Arch Gen Psychiatry · March 2002 A consensus conference on the use of placebo in mood disorder studies consisted of expert presentations on bioethics, biostatistics, unipolar depression, and bipolar disorder. Work groups considered evidence and presented statements to the group. Although ... Full text Link to item Cite

Advances in Neuropsychiatry

Journal Article Archives of Neurology · February 1, 2002 Full text Cite

Evidence-based mental health.

Journal Article Psychopharmacol Bull · 2002 Three elements exist for the practice of evidence-based mental health: development of a question, evaluation consisting of search and appraisal of the applicable literature, and synthesis of the information in the context of an individual patient’s clinica ... Link to item Cite

Antipsychotic medications and sudden cardiac death.

Journal Article Psychopharmacol Bull · 2002 The objectives of this paper are to: 1) discuss practical aspects of antipsychotic induced QT prolongation, torsades de pointes (TdP) and sudden cardiac death, 2) discuss its possible mechanisms, 3) review data for each antipsychotic medication or class of ... Link to item Cite

Structural brain investigations in affective disorders

Chapter · January 1, 2002 Computed tomography (CT) scans were used for earlier research, but magnetic resonance imaging (MRI) provides several advantages over CT. These higher-resolution images allow for more accurate measurement of structural volumes, which is facilitated by the M ... Cite

Allelic differences in the serotonin transporter-linked polymorphic region in geriatric depression.

Journal Article Am J Geriatr Psychiatry · 2002 Previous studies have examined the role of genetic variations in the serotonin transporter-linked polymorphic region (5HTTLPR) in affective disorders. The authors studied 182 older depressed subjects and 107 elderly control subjects and obtained DNA for ge ... Link to item Cite

Depression and heart disease: evidence of a link, and its therapeutic implications.

Journal Article CNS Drugs · 2002 Over several decades, a large body of evidence has emerged to suggest that depressive disorder is a risk factor for heart diseases, both aetiologically and prognostically. Several large, prospective, longitudinal studies have examined the relationship betw ... Full text Link to item Cite

Sociodemographic and clinical predictors of mortality in geriatric depression.

Journal Article Am J Geriatr Psychiatry · 2002 OBJECTIVE: It is well documented that depression and early mortality are related, and current research suggests that depression may influence vascular causes of death. The authors report on prospectively observed mortality in elderly depressed patients, co ... Link to item Cite

The Duke Somatic Treatment Algorithm for Geriatric Depression (STAGED) approach.

Journal Article Psychopharmacol Bull · 2002 Although there have been previously published algorithms for the treatment of depression, few have been rigorously studied in terms of outcome. We present the Duke Somatic Treatment Algorithm for Geriatric Depression (STAGED) approach, developed by clinici ... Link to item Cite

Provisional diagnostic criteria for depression of Alzheimer disease.

Journal Article Am J Geriatr Psychiatry · 2002 The authors, a group of investigators with extensive research and clinical experience related to both late-life depression and Alzheimer disease (AD), propose provisional affective and behavioral inclusion and exclusion diagnostic criteria for Depression o ... Link to item Cite

Practical evidence-based medicine.

Journal Article Psychopharmacol Bull · 2002 one, information is processed in step two, evidence-based libraries monitor clinical care for treatment recommendations in step three, and feedback is delivered to the clinician at the point of care in step four. This article describes the procedure for de ... Link to item Cite

Introduction - Pathophysiology of depression: The emerging role of substance P

Journal Article JOURNAL OF CLINICAL PSYCHIATRY · January 1, 2002 Link to item Cite

The relationship of MRI subcortical hyperintensities to treatment response in a trial of sertraline in geriatric depressed outpatients.

Journal Article Am J Geriatr Psychiatry · 2002 The authors examined differences in antidepressant treatment response in geriatric outpatients with high vs. low levels of magnetic resonance imaging (MRI)-defined subcortical hyperintensities (SH). Participants included 59 outpatients with mild-to-moderat ... Link to item Cite

The Depression Interview and Structured Hamilton (DISH): rationale, development, characteristics, and clinical validity.

Journal Article Psychosom Med · 2002 OBJECTIVE: The Depression Interview and Structured Hamilton (DISH) is a semistructured interview developed for the Enhancing Recovery in Coronary Heart Disease (ENRICHD) study, a multicenter clinical trial of treatment for depression and low perceived soci ... Full text Link to item Cite

MRI subcortical hyperintensities and response to sertraline in geriatric depressed outpatients

Conference 2ND INTERNATIONAL CONGRESS ON VASCULAR DEMENTIA · January 1, 2002 Link to item Cite

Clinical experience with substance P receptor (NK1) antagonists in depression.

Conference J Clin Psychiatry · 2002 Substance P (SP) belongs to the neurokinin (NK) family of neuropeptides and exerts its biological effects via interaction with the NK1 receptor. The SP-NK1 receptor system is one of the best-characterized neurotransmitter pathways in both the central and p ... Link to item Cite

Pathophysiology of depression: The emerging role of substance P

Journal Article Journal of Clinical Psychiatry · January 1, 2002 Cite

Management of late-life depression: focus on comorbid conditions.

Journal Article Psychopharmacol Bull · 2002 Depression, a heterogeneous disease often accompanied by significant medical and psychiatric comorbidity, is common among the elderly. Clinicians caring for depressed elders should look for comorbidities, as they may affect management of the patient. For e ... Link to item Cite

Delirium: diagnosis, neuropathogenesis, and treatment.

Journal Article J Psychiatr Pract · September 2001 Delirium affects more than 2 million patients in the United States each year. The onset of delirium often occurs after hospitalization and in many cases is due to medications or procedures performed during the hospitalization. Unfortunately, delirium remai ... Full text Link to item Cite

Performance feedback deficit in geriatric depression.

Journal Article Biol Psychiatry · September 1, 2001 BACKGROUND: The orbital frontal cortex is involved with processing of performance feedback. This study tests the hypothesis that older depressed subjects, compared with elderly control subjects, commit more subsequent errors after receiving feedback from a ... Full text Link to item Cite

Bupropion for weight loss: an investigation of efficacy and tolerability in overweight and obese women.

Journal Article Obes Res · September 2001 OBJECTIVE: On the basis of the clinical observations that bupropion facilitated weight loss, we investigated the efficacy and tolerability of this drug in overweight and obese adult women. RESEARCH METHODS AND PROCEDURES: A total of 50 overweight and obese ... Full text Link to item Cite

A controlled study of MRI signal hyperintensities in older depressed patients with and without hypertension.

Journal Article J Am Geriatr Soc · September 2001 OBJECTIVES: To compare the frequency/severity of signal hyperintensities--likely markers of cerebrovascular disease--in the subcortical gray and deep white matter on magnetic resonance imaging (MRI) scans of brains of hypertensive and normotensive older de ... Full text Link to item Cite

MRI correlates of suicide attempt history in unipolar depression.

Journal Article Biol Psychiatry · August 15, 2001 BACKGROUND: Suicide represents a major health problem in the United States, and prediction of suicide attempts is difficult. No structural neuroimaging studies have been done to specifically examine findings in patients who have attempted suicide. The obje ... Full text Link to item Cite

Relationship of depression to increased risk of mortality and rehospitalization in patients with congestive heart failure.

Journal Article Arch Intern Med · August 13, 2001 BACKGROUND: Patients with congestive heart failure (CHF) may have a high prevalence of depression, which may increase the risk of adverse outcomes. OBJECTIVE: To determine the prevalence and relationship of depression to outcomes of patients hospitalized w ... Full text Link to item Cite

Evidence of white matter tract disruption in MRI hyperintensities.

Journal Article Biol Psychiatry · August 1, 2001 BACKGROUND: Diffusion tensor imaging (DTI) of brain tissue measures the apparent diffusion coefficient (ADC), or isotropic diffusion, and anisotropy, or diffusion as influenced by tissue structure. We hypothesized that hyperintensities, when compared with ... Full text Link to item Cite

Reply

Journal Article Biological Psychiatry · July 2001 Full text Cite

Medial orbital frontal lesions in late-onset depression.

Journal Article Biol Psychiatry · May 1, 2001 BACKGROUND: Early studies using magnetic resonance (MR) imaging suggested that subcortical vascular changes are more prevalent in late-life depression and that they may play a role in the pathophysiology of depression. Studying the location of the lesion r ... Full text Link to item Cite

Association between selective serotonin-reuptake inhibitor therapy and heart valve regurgitation.

Journal Article Am J Cardiol · April 15, 2001 The identification of an association between fenfluramines and valvular disease has raised the possibility of a similar association between another class of medications that increases local levels of serotonin, the selective serotonin-reuptake inhibitors ( ... Full text Link to item Cite

Brain 1H-MR spectroscopy in subjects at risk for Alzheimer's disease

Journal Article NEUROBIOLOGY OF AGING · March 1, 2001 Link to item Cite

Clinical and treatment response characteristics of late-life depression associated with vascular disease: a pooled analysis of two multicenter trials with sertraline.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · February 2001 1. The safety and efficacy of sertraline in the treatment of moderate-to-severe major depression in elderly outpatients, aged 60 years and older, with comorbid vascular disease was evaluated. 2. An analysis of the pooled results for the sertraline treatmen ... Full text Link to item Cite

Effects of exercise training on cognitive functioning among depressed older men and women

Journal Article Journal of Aging and Physical Activity · January 1, 2001 The effects of a structured exercise program on the cognitive functioning of 84 clinically depressed middle-aged and older adults (mean age = 57 years) were examined. Participants were randomized to either 4 months of aerobic exercise (n = 42) or antidepre ... Full text Cite

Enhancing Recovery in Coronary Heart Disease (ENRICHD) study intervention: rationale and design.

Journal Article Psychosom Med · 2001 OBJECTIVE: Depression and low social support are risk factors for medical morbidity and mortality after acute MI. The ENRICHD study is a multicenter, randomized, controlled clinical trial of a cognitive-behavioral treatment for depression and low social su ... Link to item Cite

Informant-rated cognitive symptoms in normal aging, mild cognitive impairment, and dementia. Initial development of an informant-rated screen (Brief Cognitive Scale) for mild cognitive impairment and dementia.

Journal Article Psychopharmacol Bull · 2001 An informant-rated cognitive screen may have the potential to reliably help detect early dementia. A valuable scale should have good interitem associations and strong reliability when tested in groups with and without cognitive impairment. Our scale, the B ... Link to item Cite

Donepezil for Down's syndrome.

Journal Article Am J Psychiatry · January 2001 Full text Link to item Cite

Clinical trials in Alzheimer's disease. Calculating Alzheimer's Disease Assessment Scale-cognitive subsection with the data from the consortium to establish a registry for Alzheimer's disease.

Journal Article Psychopharmacol Bull · 2001 The database of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) is a seminal work in the field of cognitive dysfunction and Alzheimer's disease. This 24-center study of 1,094 patients with Alzheimer's disease who received no treatmen ... Link to item Cite

A double-blind comparison of sertraline and fluoxetine in depressed elderly patients

Journal Article Primary Care Companion to the Journal of Clinical Psychiatry · December 1, 2000 Background: There has been a paucity of well-designed studies comparing selective serotonin reuptake inhibitor (SSRI) medications in the treatment of depression in the elderly. This multicenter study was designed to examine the efficacy and safety of sertr ... Cite

Reduction of orbital frontal cortex volume in geriatric depression.

Journal Article Biol Psychiatry · November 15, 2000 BACKGROUND: Postmortem studies have documented abnormalities in the medial orbital frontal cortex in depressed patients. In this study we evaluated whether atrophy of this region can be identified in older depressed patients using magnetic resonance imagin ... Full text Link to item Cite

Grey-matter lesions and dementia.

Journal Article Lancet · November 11, 2000 Full text Link to item Cite

Depression as a contributing factor in cerebrovascular disease.

Journal Article Am Heart J · October 2000 Stroke is a leading cause of morbidity and mortality in the United States. Physical and psychological impairment from stroke may negatively affect quality of life. From a psychological perspective, depression, which is common in stroke patients, may influe ... Full text Link to item Cite

Randomized trial of sertraline in patients with unexplained chest pain of noncardiac origin.

Journal Article Am Heart J · September 2000 BACKGROUND: Between 10% and 30% of patients with symptoms similar to angina and sufficient to justify cardiac catheterization are found to have normal coronary angiograms. Treatment of patients with chest pain with no apparent cardiac cause is a major clin ... Full text Link to item Cite

Hippocampal volume in geriatric depression.

Journal Article Biol Psychiatry · August 15, 2000 BACKGROUND: There is a growing literature on the importance of hippocampal volume in geriatric depression. METHODS: We examined hippocampal volume in a group of elderly depressed patients and a group of elderly control subjects (N = 66 geriatric depressed ... Full text Link to item Cite

A double-blind comparison of sertraline and fluoxetine in depressed elderly outpatients.

Journal Article J Clin Psychiatry · August 2000 BACKGROUND: There has been a paucity of well-designed studies comparing selective serotonin reuptake inhibitor (SSRI) medications in the treatment of depression in the elderly. This multicenter study was designed to examine the efficacy and safety of sertr ... Full text Link to item Cite

Hippocampal sulcal cavities on MRI: relationship to age and apolipoprotein E genotype.

Journal Article Neurology · June 13, 2000 Hippocampal sulcal cavities are usually considered incidental findings on brain MRI. In a group of 92 elderly volunteers, the authors graded the number and size of hippocampal sulcal cavities with brain MRI to obtain a cavity score. Cavity scores increased ... Full text Link to item Cite

Efficient trial designs to reduce placebo requirements.

Journal Article Biol Psychiatry · April 15, 2000 This brief discussion summarizes possible trial design changes that could be utilized to reduce the number of subjects exposed to ineffective treatment--in this case placebo; however, these designs are fairly complex and have not been implemented sufficien ... Full text Link to item Cite

Dr. Ahearn and Colleagues Reply

Journal Article American Journal of Psychiatry · February 1, 2000 Full text Cite

Anxious depression among the elderly: Clinical and phenomenological correlates

Journal Article Aging and Mental Health · January 1, 2000 This study investigated clinical, historical and phenomenological correlates of anxious depression in a sample of 159 depressed elders. Regression analyses indicated that comorbidity of anxiety and depression was associated with a history of a greater numb ... Full text Cite

Exercise treatment for major depression: maintenance of therapeutic benefit at 10 months.

Journal Article Psychosom Med · 2000 OBJECTIVE: The purpose of this study was to assess the status of 156 adult volunteers with major depressive disorder (MDD) 6 months after completion of a study in which they were randomly assigned to a 4-month course of aerobic exercise, sertraline therapy ... Full text Link to item Cite

The relationship of social support, social networks and negative events with depression in patients with coronary artery disease

Journal Article Aging and Mental Health · January 1, 2000 This study examined the relationship of social relationships and negative life events with major depression among 335 inpatients with coronary artery disease (CAD) who were free of neurological illnesses. Depression was assessed using the Duke Depression E ... Full text Cite

Cerebrovascular changes in late life depression

Journal Article International Journal of Geriatric Psychopharmacology · January 1, 2000 The causes of vascular depression in the elderly are poorly understood. It appears as though the mechanism of the development of depression in late life involves more subcortical brain abnormalities and less genetic input than their younger counterparts. W ... Cite

New onset and remission of suicidal ideation among a depressed adult sample.

Journal Article J Affect Disord · November 1999 BACKGROUND: Previous research has demonstrated that suicidal ideation often predicts suicide completion. METHODS: The present study examined clinical and phenomenological variables associated with the presence, development and remission of suicidal ideatio ... Full text Link to item Cite

Correlates of suicidal ideation among an elderly depressed sample.

Journal Article J Affect Disord · November 1999 BACKGROUND: Suicidal ideation has been shown to be strongly associated with suicide completion and elders take their own lives more than any other age group. METHODS: The present study examined clinical and phenomenological correlates of suicidal ideation ... Full text Link to item Cite

Effects of exercise training on older patients with major depression.

Journal Article Arch Intern Med · October 25, 1999 BACKGROUND: Previous observational and interventional studies have suggested that regular physical exercise may be associated with reduced symptoms of depression. However, the extent to which exercise training may reduce depressive symptoms in older patien ... Full text Link to item Cite

Magnetic resonance assessment of cerebral perfusion in depressed cardiac patients: preliminary findings.

Journal Article Am J Psychiatry · October 1999 OBJECTIVE: The authors investigated the links between depression, cardiac disease, and microcirculatory cerebral blood flow (CBF). METHOD: A magnetic resonance imaging technique based on arterial spin tagging was used to estimate microcirculatory CBF in de ... Full text Link to item Cite

Perceived social support among depressed elderly, middle-aged, and young-adult samples: cross-sectional and longitudinal analyses.

Journal Article J Affect Disord · October 1999 BACKGROUND: A number of studies have concluded that the perceived quality of support is more strongly associated with mental health than with the actual structure of personal networks. This study examined clinical, historical, and phenomenological variable ... Full text Link to item Cite

Cerebrovascular disease and depression symptoms in the cardiovascular health study.

Journal Article Stroke · October 1999 BACKGROUND AND PURPOSE: Evidence is mounting linking cerebrovascular disease with depressive symptoms in the elderly. Lesions in both white and gray matter have been associated with depressive symptoms and major depression. We sought to investigate the rel ... Full text Link to item Cite

Rivastigmine slows stage specific global deterioration in Alzheimer's disease

Conference JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · September 1, 1999 Link to item Cite

Candidate neuroanatomic substrates of psychosis in old-aged depression.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · July 1999 1. The authors investigated the candidate neuroanatomic substrates underlying delusional thought disorder in old-aged depressed patients by using magnetic resonance imaging (MRI), and examined the relationship between volumes for individual brain structure ... Full text Link to item Cite

Clinical, demographic and social characteristics of psychotic depression.

Journal Article Psychiatry Res · May 31, 1999 The goal of this study was to compare the clinical, demographic and social characteristics of psychotic and non-psychotic depression in the elderly and younger age groups. Depressed patients (n = 674) meeting DSM-III-R criteria for major depressive episode ... Full text Link to item Cite

Hyperintense lesions on magnetic resonance images in bipolar disorder.

Journal Article Biol Psychiatry · April 15, 1999 BACKGROUND: To examine the magnetic resonance (MR) images of bipolar patients across a wide age range for the presence of hyperintense lesions compared to age- and gender-matched control subjects. METHODS: Consecutive admissions to a mood disorders unit ov ... Full text Link to item Cite

Cholinergic therapy for Down's syndrome.

Journal Article Lancet · March 27, 1999 Full text Link to item Cite

The effect of major depression on functional status in patients with coronary artery disease.

Journal Article J Am Geriatr Soc · March 1999 OBJECTIVE: To examine the effect of major depression on reported functional status in a group of patients with coronary artery disease (CAD). SETTING: An inpatient cardiology service. PARTICIPANTS: Three hundred thirty-five inpatients with coronary artery ... Full text Link to item Cite

Neuropsychological functioning and MRI signal hyperintensities in geriatric depression.

Journal Article Am J Psychiatry · March 1999 OBJECTIVE: The purpose of this study was to examine the relationship between signal hyperintensities--a probable marker of underlying pathology--on T2-weighted magnetic resonance brain scans and neuropsychological test findings in elderly depressed and nor ... Full text Link to item Cite

A neuroanatomic model for depression.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · February 1999 1. Emotion and mood, once thought to be governed solely by the limbic system of the brain, now are thought to be influenced by numerous nonlimbic central nervous system structures as well. 2. The present review discusses several important brain structures ... Full text Link to item Cite

The association between physical activity and depression in older depressed adults

Journal Article Journal of Aging and Physical Activity · January 1, 1999 Previous studies of younger, healthy individuals have demonstrated an inverse relationship between physical activity and depression. The present study addressed the relation between self-reported physical activity and symptoms of depression in 146 men and ... Full text Cite

Anxiety reduces baroreflex cardiac control in older adults with major depression.

Journal Article Psychosom Med · 1999 OBJECTIVE: Although depression and anxiety predict risk of cardiac mortality, the contributions of depression and anxiety to vagal cardiac control have not been systematically evaluated. The goal of this study was to examine the relationship between state ... Full text Link to item Cite

Disability in geriatric depression.

Journal Article Am J Geriatr Psychiatry · 1999 The authors examined impairment in self-maintenance skills and in instrumental activities of daily living (IADL) among 211 older patients with unipolar major depression. In regression models, self-maintenance impairment was associated with older age, less ... Link to item Cite

Brain imaging correlates.

Journal Article J Clin Psychiatry · 1999 Because aggressive behavior occurs in so many psychiatric disorders, it is important to have an understanding of the aggression complex of symptoms, which occurs in posttraumatic stress disorder, bipolar disorder, depression, dementia, schizophrenia, atten ... Link to item Cite

Magnetic-resonance morphometry in patients with major depression.

Journal Article Psychiatry Res · November 9, 1998 Magnetic-resonance morphometry performed on 72 patients with major depression compared with 38 control subjects replicated previously reported, statistically significant reductions in the volumes of the caudate (P < 0.03) and putamen (P < 0.05) in depresse ... Full text Link to item Cite

Familial leukoencephalopathy in bipolar disorder.

Journal Article Am J Psychiatry · November 1998 OBJECTIVE: Imaging studies of patients with bipolar disorder demonstrate changes in deep white matter and subcortical gray nuclei that are seen as focal hyperintensities on T2-weighted magnetic resonance imaging (MRI). The objective of this study was to ex ... Full text Link to item Cite

Magnetic resonance imaging correlates of depression in early- and late-onset Alzheimer's disease.

Journal Article Biol Psychiatry · October 1, 1998 BACKGROUND: Depressive symptoms are frequent complications of Alzheimer's disease (AD). We hypothesized that AD patients with depression would be more likely than nondepressed AD patients to show deep white-matter, subcortical gray-matter, and periventricu ... Full text Link to item Cite

Depression and social support in elderly patients with cardiac disease.

Journal Article Am Heart J · September 1998 BACKGROUND: Depression is common among patients with cardiac disease. A number of psychosocial factors may affect the relationship between physical health and depression. There is evidence from the psychiatric literature suggesting that negative life event ... Full text Link to item Cite

Magnetic resonance imaging signal hypointensity and iron content of putamen nuclei in elderly depressed patients.

Journal Article Psychiatry Res · August 26, 1998 We previously introduced a semiquantitative scale for assessment of iron content of putamen nuclei as determined by magnetic resonance imaging (MRI)--the Signal Hypointensity in the Putamen (SHIP) scale. Such hypointensity may be related to putamen nuclei ... Full text Link to item Cite

Quantitative analysis of T2 signal intensities in Alzheimer's disease.

Journal Article Psychiatry Res · June 30, 1998 Hypointensities (focal areas of decreased signal intensity) have been reported on T2 weighted magnetic resonance images (MRI) in normal aging and in some neurological disease processes. Increased concentrations of iron have been suggested as one cause of t ... Full text Link to item Cite

Psychoneuroendocrinology and brain imaging in depression.

Journal Article Psychiatr Clin North Am · June 1998 In the past three decades, psychoneuroendocrinologic investigations have generated a great volume of information, particularly in the field of affective disorders, which has formed the basis for designing studies with newer tools such as anatomic and funct ... Full text Link to item Cite

Metabolic brain mapping in Alzheimer's disease using proton magnetic resonance spectroscopy.

Journal Article Psychiatry Res · May 20, 1998 Alzheimer's disease (AD) is a progressive disorder associated with disruption of neuronal function and neuronal loss. N-acetylaspartate (NAA) is a marker of neuronal content and can be assessed using proton (1H) magnetic resonance spectroscopy (MRS). We ut ... Full text Link to item Cite

Structural neuroimaging and mood disorders: recent findings, implications for classification, and future directions.

Journal Article Biol Psychiatry · May 15, 1998 Neuroimaging is playing an increasing role in research of affective disorders, with investigators examining both volumetric changes of specific brain structures and vascular changes within white and gray matter. Recent studies have attempted to make clinic ... Full text Link to item Cite

Neuroanatomic localization of magnetic resonance imaging signal hyperintensities in geriatric depression.

Journal Article Stroke · March 1998 BACKGROUND AND PURPOSE: Increased frequency and severity of signal hyperintensities have been regularly reported in elderly depressed patients compared with normal subjects, however, greater neuroanatomic localization of lesions has been limited. METHODS: ... Full text Link to item Cite

Psychotherapeutic agents in older adults. Metabolism, bioavailability, and drug interactions.

Journal Article Clin Geriatr Med · February 1998 This article presents clinically relevant drug interactions which may confront the geriatric psychiatrist. Changes in drug metabolism due to aging, higher medical comorbidity, and frequent polypharmacy all place the older patient at a greater risk of devel ... Link to item Cite

Anxiety and vagal control of heart rate.

Journal Article Psychosom Med · 1998 OBJECTIVE: Prospective studies have demonstrated that anxiety predicts sudden cardiac death, but the mechanism underlying this increased risk is unclear. This study examined whether anxiety is associated with reductions in vagal control of heart rate in he ... Full text Link to item Cite

Suicidal behaviors in depressed men with a family history of suicide: Effects of psychosocial factors and age

Journal Article Aging and Mental Health · January 1, 1998 Effects of impaired social support and stressful life events on non-lethal suicidal behaviors were examined in a clinical sample of high-risk patients: depressed adult men with a family history of suicide or attempted suicide. All subjects (N = 79) were pa ... Full text Cite

Age of first onset of bipolar disorder: demographic, family history, and psychosocial correlates.

Journal Article Depress Anxiety · 1998 The literature suggests that bipolar elders with early and late onset of the disorder present with different demographic, family history, and psychosocial profiles, which are less well characterized than those for elderly unipolar patients. In this cross-s ... Link to item Cite

Six-month outcomes for MRI-related vascular depression.

Journal Article Depress Anxiety · 1998 The purpose of this paper is to estimate the relative probabilities of 6-month recovery from an index episode of major depression for subjects with and without MRI-confirmed vascular brain changes. In this cohort study, 57 depressed subjects from the Duke ... Full text Link to item Cite

Vascular dementia: The end stage of cerebral vascular disease

Journal Article Current Opinion in Psychiatry · January 1, 1998 Recent research on vascular dementia has focused on improving diagnostic criteria, classification, etiology risk factors modification, and interaction with Alzheimer's dementia. ... Full text Cite

Age and sex effects on brain morphology.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · November 1997 1. Brain morphology can be assessed readily in vivo using magnetic resonance imaging (MRI). 2. In this study, the effects of age and sex on whole-brain morphology were examined using an operator-controlled computer-segmentation protocol. 3. Results indicat ... Full text Link to item Cite

A review of racial differences in geriatric depression: implications for care and clinical research.

Journal Article J Natl Med Assoc · November 1997 How racial differences influence depressed elders' seeking and obtaining treatment for depression is poorly understood. Studies in other medical illnesses show older African Americans use fewer health-care services for heart disease, stroke, and renal dial ... Link to item Cite

Structural changes in the brain of patients with bipolar affective disorder by MRI: a review of the literature.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · November 1997 1. Current literature was searched to evaluate the use of magnetic resonance imaging in patients with bipolar disorder. 2. The presence of white matter hyperintensities, differences in temporal lobe and hippocampal structures, and ventricular enlargement i ... Full text Link to item Cite

A new MRI ratio method for in-vivo estimation of signal hypointensity in aging and Alzheimer's disease.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · November 1997 1. Alzheimer's Disease (AD) is accompanied by a disruption in iron metabolism. There is no universally accepted method for detecting brain iron. 2. The authors have developed a novel "ratio" method which uses the red nucleus as an internal reference. We po ... Full text Link to item Cite

New frontiers in psychiatric neuroimaging.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · November 1997 Full text Link to item Cite

Psychosocial and physical correlates of chronic depression.

Journal Article Psychiatry Res · October 10, 1997 This study used a case-control design to address differences in psychosocial, physical and clinical profiles between subjects who presented with a chronic index episode of major depression and those who presented with a non-chronic index episode. Subjects ... Full text Link to item Cite

A repeat proton magnetic resonance spectroscopy study in social phobia.

Journal Article Biol Psychiatry · September 15, 1997 Peak spectral amplitudes for choline moieties (Cho), creatine (Cr), N-acetylaspartate (NAA), and myo-inositol (mI) were examined using proton magnetic resonance spectroscopy in 19 social-phobia patients and 10 controls. Compared with controls, social phobi ... Full text Link to item Cite

The Alzheimer's Disease Assessment Scale: patterns and predictors of baseline cognitive performance in multicenter Alzheimer's disease trials.

Journal Article Neurology · June 1997 The cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-Cog) is used as an efficacy measure in clinical drug trials of Alzheimer's disease (AD). We used data from 1,648 AD participants in two identical 26-week multicenter drug trials to ex ... Full text Link to item Cite

MRI-defined vascular depression.

Journal Article Am J Psychiatry · April 1997 OBJECTIVE: The authors' goal was to characterize the clinical and demographic features of vascular depression. METHOD: They classified 89 depressed patients into two groups-those with vascular (N = 32) and nonvascular (N = 57) depression-on the basis of ex ... Full text Link to item Cite

Screening for trauma history on an inpatient affective-disorders unit: a pilot study.

Journal Article J Trauma Stress · April 1997 Psychiatric inpatients (N = 343) admitted to an affective-disorders unit were administered a self-rating Trauma Questionnaire (TQ) to evaluate life history of traumatic experiences. Eighty four percent of the sample identified at least one traumatic-event ... Full text Link to item Cite

Response

Journal Article Biological Psychiatry · April 1997 Full text Cite

Limbic circuits and neuropsychiatric disorders. Functional anatomy and neuroimaging findings.

Journal Article Neuroimaging Clin N Am · February 1997 The limbic system seems to be involved in the pathophysiology of neuropsychiatric disorders, including dementia, schizophrenia, affective disorders, and amnestic disorders. These findings are subtle and largely went undetected until the advent of modern ne ... Link to item Cite

Memory, language, and praxis in Alzheimer's disease: norms for outpatient clinical trial populations.

Journal Article Psychopharmacol Bull · 1997 The cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-Cog) is designed specifically to assess memory, language, and praxis dysfunctions characteristic of Alzheimer's disease (AD). In this report, we use data from 1,648 AD participants in ... Link to item Cite

Recent advances in the pharmacologic treatment of bipolar illness

Journal Article Psychiatric Annals · January 1, 1997 Full text Cite

Are SSRIs better than TCAs? Comparison of SSRIs and TCAs: a meta-analysis.

Journal Article Depress Anxiety · 1997 In this analysis we examined studies of tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) to compare efficacy and drop-out rates. Frequency of reported side effects was also studied. Using Medline, we located 36 clinical ... Full text Link to item Cite

"Vascular depression": A new subtype of geriatric depression

Conference INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE · January 1, 1997 Link to item Cite

Magnetic resonance imaging changes in putamen nuclei iron content and distribution in normal subjects.

Journal Article Psychiatry Res · November 25, 1996 To study patterns of iron deposition in the putamen in aging, we reviewed brain magnetic resonance imaging (MRI) scans of 56 normal subjects. We developed the Signal Hypointensity in the Putamen (SHIP) Scale, a semiquantitative measure, to evaluate putamen ... Full text Link to item Cite

Accuracy and reproducibility of brain and tissue volumes using a magnetic resonance segmentation method.

Journal Article Psychiatry Res · October 7, 1996 Magnetic resonance (MR) imaging now allows the qualitative and quantitative assessment of the human brain in vivo. As MR imaging resolution has improved, precise measurement of small brain structures has become possible. Methods of measuring brain regions ... Full text Link to item Cite

The pathophysiologic basis for late-life depression: Imaging studies of the aging brain

Journal Article American Journal of Geriatric Psychiatry · September 1, 1996 Available evidence on late-life depression does not support the concept that psychological or social factors are the sole contributors. Several studies suggest that there is a lower genetic loading to late-onset depression; thus, late-life depression may b ... Cite

The pathophysiologic basis for late-life depression - Imaging studies of the aging brain

Journal Article AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · September 1, 1996 Link to item Cite

MRI signal hyperintensities in geriatric depression.

Journal Article Am J Psychiatry · September 1996 OBJECTIVE: The authors rated periventricular and subcortical signal hyperintensities on magnetic resonance imaging (MRI) scans in elderly patients with depression and in normal subjects with similar demographic features to examine whether such changes disc ... Full text Link to item Cite

MRI brain changes and treatment outcome in geriatric depression: A preliminary study

Conference AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · September 1, 1996 Link to item Cite

MRI morphometric analysis and neuropsychological function in patients with neurofibromatosis.

Journal Article Neuroreport · August 12, 1996 Volumes of cerebral gray and white matter were measured in 22 children with neurofibromatosis type 1 (NF1) and in 20 controls. Judgment of Line Orientation (JLO) and the Developmental Test of Visual-Motor Integration (DTVMI) were administered to 16 of the ... Full text Link to item Cite

Sociodemographic and clinical correlates of number of previous depressive episodes in the depressed elderly.

Journal Article J Affect Disord · July 8, 1996 Age of onset has been used as a correlate of depressive symptomatology in the elderly. Examining frequency of episodes may improve our ability to make such correlations. The authors studied variations in an index presentation of depression in late life bas ... Full text Link to item Cite

Magnetic resonance imaging of Alzheimer's disease.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · May 1996 1. Although dementia is caused by a heterogeneous group of diseases and pathologic states, Alzheimer's disease is the largest cause, estimated to account for 50 to 75% of all dementias. 2. Unfortunately, confirmation of Alzheimer's disease (AD) requires po ... Full text Link to item Cite

Reproducibility of high spatial resolution proton magnetic resonance spectroscopic imaging in the human brain.

Journal Article Magn Reson Med · April 1996 The application of proton (1H) magnetic resonance spectroscopic imaging (MRSI) allows for noninvasive, localized analyses of brain biochemistry; however, minimal work has been devoted to the evaluation of 1H MRSI reproducibility. This study examined the re ... Full text Link to item Cite

Imaging in acquired immune deficiency syndrome dementia complex (AIDS dementia complex): a review.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · April 1996 1. Since 1986, the AIDS dementia complex has been recognized increasingly as a significant sequela of HIV infection. Though the pathogenesis remains poorly characterized and the diagnosis is one of exclusion, research utilizing various imaging techniques h ... Full text Link to item Cite

MRI changes in schizophrenia in late life: a preliminary controlled study.

Journal Article Psychiatry Res · March 29, 1996 The aim of this pilot study was to compare cerebral changes on magnetic resonance imaging (MRI) scans in elderly schizophrenic subjects with those in psychiatric and normal control subjects. We compared the MRIs of 19 subjects with schizophrenia, 19 age- a ... Full text Link to item Cite

Nuclear magnetic resonance spectroscopy: new insights into the pathophysiology of mood disorders.

Journal Article Depression · 1996 Magnetic Resonance Spectroscopy (MRS) is a novel non-invasive approach for investigation of in vivo brain neurochemistry. In this paper, we review the initial studies conducted in mood disorders. 31P MRS studies have suggested membrane phospholipid and ene ... Full text Link to item Cite

Depression in patients with coronary artery disease.

Journal Article Depression · 1996 Depression is more prevalent in patients with coronary artery disease (CAD) than in the general elderly population. Although CAD patients with depression have higher mortality rates, depression is often not recognized and treated in these patients. We admi ... Full text Link to item Cite

Decision model for the acute treatment of mania.

Journal Article Depress Anxiety · 1996 Decision making in psychiatric diagnosis and treatment has not been evaluated systematically. The authors present a model for treatment of an acute manic episode using a decision analysis software program. Six treatment options were put into the model: lit ... Full text Link to item Cite

Clinical advances in monoamine oxidase inhibitor therapies - Kennedy,SH

Journal Article AMERICAN JOURNAL OF PSYCHIATRY · January 1, 1996 Link to item Cite

Neural network methods for volumetric magnetic resonance imaging of the human brain

Journal Article Proceedings of the IEEE · January 1, 1996 Multimedia, including imaging and videoconferencing, is becoming the predominant mode of professional and technical communication. In the medical arena, multimedia systems will have to deal with images of different types, including live videos of the parti ... Full text Cite

Neural networks for volumetric MR imaging of the brain

Journal Article Proceedings of International Workshop on Neural Networks for Identification, Control, Robotics, and Signal/Image Processing, NICROSP · January 1, 1996 Multimedia, including imaging and videoconferencing, is becoming the predominant mode of professional and technical communication. In the medical arena Multimedia Systems will have to deal with images of different types, including live videos of the partic ... Cite

Nuclear magnetic resonance spectroscopy: a review of neuropsychiatric applications.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · July 1995 1. Magnetic resonance spectroscopy (MRS) is a powerful new neuropsychiatric research tool which allows for the noninvasive investigation of in vivo biochemistry. This review focuses on the recent applications of MRS to in vivo neuropsychiatric research. 2. ... Full text Link to item Cite

A comparison of stereology and segmentation techniques for volumetric measurements of lateral ventricles in magnetic resonance imaging.

Journal Article Psychiatry Res · May 31, 1995 Lateral ventricular volumes were measured on magnetic resonance imaging (MRI) scans by independent raters in 18 subjects (11 psychotic patients and 7 healthy control subjects) with two different approaches: a point-counting stereological (PCS) technique an ... Full text Link to item Cite

Magnetic resonance imaging using deoxyhemoglobin contrast versus positron emission tomography in the assessment of brain function.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · May 1995 1. Function of the brain can be assessed through radiologic imaging to determine physiology of underlying tissue. 2. Until recently, positron emission tomography has been the standard tool with which to study function. 3. In the past few years, several inv ... Full text Link to item Cite

Clinical and phenomenological comparisons of late-onset and early-onset depression.

Journal Article Am J Psychiatry · May 1995 OBJECTIVE: The authors examined the relationship between age at onset of first depressive episode and clinical features in elderly depressed patients. METHOD: They used data on age at onset and clinical features in 246 elderly depressed patients treated at ... Full text Link to item Cite

Neuroleptic treatment and caudate plasticity.

Journal Article Lancet · March 18, 1995 Link to item Cite

Arteriosclerotic depression.

Journal Article Med Hypotheses · February 1995 Depression is a psychiatric syndrome seen in about 1-2% of elderly patients. When depression is seen for the first time late in life, genetic and psychosocial factors appear to be less important. Structural changes in the brain appear to be more important. ... Full text Link to item Cite

Religious coping and cognitive symptoms of depression in elderly medical patients.

Journal Article Psychosomatics · 1995 The investigators examined associations between depressive symptom type and religious coping in 832 consecutively admitted older medical inpatients. Cognitive symptoms of depression, but not somatic symptoms, were related to religious coping. Boredom, loss ... Full text Link to item Cite

Ipsilateral subcortical atrophy associated with temporal lobectomy.

Journal Article Psychiatry Res · December 1994 Stereologic methods for determining the volume of cerebral structures in vivo via magnetic resonance imaging have identified unilateral hippocampal atrophy among patients with complex partial epilepsy of temporal lobe origin. Metabolic imaging has also ide ... Full text Link to item Cite

Geniculocalcarine hyperintensities on brain magnetic resonance imaging associated with visual hallucinations in the elderly.

Journal Article Psychiatry Res · December 1994 Magnetic resonance scans of five geriatric patients presenting with formed visual hallucinations in the absence of other psychopathology were compared with those of 12 healthy elderly subjects for the presence and extent of subcortical and periventricular ... Full text Link to item Cite

Apolipoprotein E epsilon 4.

Journal Article Neurology · December 1994 Full text Link to item Cite

Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · November 1994 1. Seven subjects with depression and matched controls were studied using proton spectroscopy to test the hypothesis that choline will be elevated in depression. 2. The proton spectroscopy was repeated after recovery from depression. 3. The study confirmed ... Full text Link to item Cite

Further studies on platelet serotonin transporter binding in depression.

Journal Article Am J Psychiatry · November 1994 OBJECTIVE: There is an impressive literature implicating abnormalities in serotonergic neural systems in depression. Many investigators, but not all, have reported low numbers of platelet and brain serotonin (5-HT) transporter sites in drug-free depressed ... Full text Link to item Cite

Proton spectroscopy of human brain: effects of age and sex.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · October 1994 1. The present study was done to assess the brain metabolites measured by proton magnetic resonance spectroscopy (MRS) in normal individuals. 2. Proton spectroscopy STEAM voxel technique with chemical shift imaging was used to provide localized metabolic i ... Full text Link to item Cite

Endocrine Factors in Depression

Journal Article Psychiatric Annals · October 1994 After a thorough diagnostic evaluation, patients initially presenting with depression are often found to have an endocrine disorder. ... Full text Cite

Relative accuracy and reproducibility of regional MRI brain volumes for point-counting methods.

Journal Article Psychiatry Res · September 1994 Volumetric magnetic resonance imaging (MRI) methods for the measurement of various neuroanatomical regions are of great interest in studies of neuropsychiatric disorders. Both manual and semiautomated methods have been developed. Manual methods include tra ... Full text Link to item Cite

MR imaging of diseases of the limbic system.

Journal Article AJR Am J Roentgenol · September 1994 The limbic system refers to the part of the brain that is involved in emotional expression and in cognitive and somatomotor control systems; it most likely also has a significant role in the pathogenesis of certain dementias, neuropsychiatric disturbances, ... Full text Link to item Cite

Adinazolam sustained-release treatment of panic disorder: a double-blind study.

Journal Article J Clin Psychopharmacol · August 1994 Two hundred six outpatients with panic disorder and agoraphobia were randomly assigned to receive 4 weeks of treatment with placebo or sustained-release adinazolam under double-blind conditions. Eighty-eight percent of patients receiving drug and 85% of pa ... Link to item Cite

Magnetic resonance imaging in social phobia.

Journal Article Psychiatry Res · April 1994 Recent studies have implicated dopamine and the basal ganglia circuits in the pathophysiology of social phobia. Twenty-two patients who met DSM-III-R criteria for social phobia and 22 age- and sex-matched control subjects underwent magnetic resonance imagi ... Full text Link to item Cite

Bicaudate index on magnetic resonance imaging: effects of normal aging.

Journal Article J Geriatr Psychiatry Neurol · 1994 The bicaudate and bifrontal indices have been used in prior computed tomographic studies to investigate atrophy of the caudate nuclei in patients with Huntington's chorea and cerebral atrophy. However, the relationship between these indices and caudate vol ... Link to item Cite

Changes in pituitary gland signal intensity and morphology as evaluated by magnetic resonance imaging in aging, depression, and by gender

Journal Article Depression · January 1, 1994 Magnetic resonance images (MRI) were used to measure anterior (A) and posterior (P) pituitary lobe signal intensity changes with age and by gender in 35 normal controls and 19 depressed patients. Females in the control group had a significant increase in b ... Full text Cite

Apolipoprotein E ε4

Journal Article Neurology · January 1, 1994 Full text Cite

An objective method for edge detection in MRI morphometry

Journal Article European Psychiatry · January 1, 1994 We describe a simple method to objectively identify the threshold for edge detection in morphometric measurement of brain structures. This method correlates highly with the subjective operator-driven approach to edge detection. While the objective approach ... Cite

Magnetic resonance spectroscopy in social phobia: preliminary findings.

Journal Article J Clin Psychiatry · December 1993 Proton localized magnetic resonance spectroscopy was studied in 20 social phobics and 20 age- and sex-matched controls. Stimulated Echo Acquisition Mode volume element localization was used with chemical shift imaging. Choline and creatine signal-to-noise ... Link to item Cite

Treatment of social phobia with clonazepam and placebo.

Journal Article J Clin Psychopharmacol · December 1993 Clonazepam and placebo were administered in a double-blind pilot study to 75 outpatients with social phobia. The mean maximum dose of clonazepam was 2.4 mg/day at endpoint (range, 0.5 to 3 mg). Treatment was continued for up to 10 weeks. The results of an ... Link to item Cite

The role of nuclear magnetic resonance imaging in psychiatric research.

Conference J Clin Psychiatry · December 1993 Magnetic resonance imaging (MRI) has become an important tool in the investigation of cerebral abnormalities associated with psychiatric illnesses. There are a number of benefits of investigating psychiatric illness with MRI, which is superior to computed ... Link to item Cite

Pituitary and Adrenal Changes in Depression

Journal Article Psychiatric Annals · December 1993 Little is known about the mechanisms underlying the HPA abnormalities seen in depression or the relative contribution of each of the different structures involved in the regulation of the HPA axis. ... Full text Cite

Profile of depressive symptoms in younger and older medical inpatients with major depression.

Journal Article J Am Geriatr Soc · November 1993 OBJECTIVE: To examine and compare the profile of cognitive symptoms, somatic symptoms, and somatic complaints in younger and older medical inpatients diagnosed with major depressive disorder (MDD). DESIGN: Cross-sectional cohort. PATIENTS AND SETTING: Male ... Full text Link to item Cite

Neuropathology in affective illness.

Journal Article Am J Psychiatry · October 1993 Full text Link to item Cite

Hypercortisolemia and hippocampal changes in depression.

Journal Article Psychiatry Res · May 1993 Hypercortisolemia is a frequently observed abnormality in patients with major depression. It has been hypothesized that the hippocampus, as a major feedback site for glucocorticoids, is involved in the pathophysiology of hypercortisolemia. Some have in fac ... Full text Link to item Cite

Relationship of past depressive episodes to symptom severity and treatment response in panic disorder with agoraphobia.

Journal Article J Clin Psychiatry · March 1993 BACKGROUND: Many investigators have reported that panic disorder (PD) patients with comorbid major depression (MD) have more severe symptoms and a poorer response to treatment than patients with PD alone. It is not known if this is due to a distinct and mo ... Link to item Cite

Reduction of cerebellar volume in major depression: A controlled MRI study

Journal Article Depression · January 1, 1993 A systematic sampling stereological method of serially acquired axial intermediate T2‐weighted Spin echo magnetic resonance imaging (MRI) of the brain was used to measure cerebellar volume in 30 patients who fulfilled DSM III criteria for major depression ... Full text Cite

Magnetic‐resonance morphometry: Image‐analysis methodology development for affective disorder

Journal Article Depression · January 1, 1993 In this article we review some important methodological issues for measurement of brain structures and lesions visualized on magnetic resonance (MR) imaging. Such issues include the method of sectioning, number of slices, shape of the structure, orientatio ... Full text Cite

MRI detection of abnormality in the corpus callosum and late‐onset depression

Journal Article Depression · January 1, 1993 A Case of a 75‐year‐old female with late‐onset depression and MRI finding of a T2 signal hyperintensity in the anterior corpus callosum is presented. This case furthers the clinical anatomical association between late‐onset mood disorders and frontal subco ... Full text Cite

The corticotropin releasing factor stimulation test in patients with major depression: Relationship to dexamethasone suppression test results

Journal Article Depression · January 1, 1993 Depressed patients have been reported to exhibit both a blunted ACTH response to corticotropin‐releasing factor (CRF) and abnormal suppression of plasma cortisol following the administration of dexamethasone. The purpose of the study was to determine the r ... Full text Cite

Adrenal Gland Enlargement in Major Depression-Reply

Journal Article Archives of General Psychiatry · January 1, 1993 Full text Cite

Diminished subcortical nuclei volumes in Parkinson's disease by MR imaging.

Journal Article J Neural Transm Suppl · 1993 Parkinson's disease (PD) is associated with changes in the substantia nigra, which communicates with subcortical nuclei. This study investigates subcortical nuclei volume in PD in vivo by magnetic resonance (MR) imaging. Caudate, putaminal, and thalamic nu ... Link to item Cite

Neuroanatomical substrates of depression in the elderly.

Journal Article Eur Arch Psychiatry Clin Neurosci · 1993 The etiology of depression in the elderly is poorly understood. In this study, magnetic resonance imaging was used to evaluate the role of subcortical structures in the pathophysiology of depression in the elderly. Elderly depressed patients were found to ... Full text Link to item Cite

Interuncal distance measurements in healthy volunteers and in patients with Alzheimer disease.

Journal Article AJNR Am J Neuroradiol · 1993 PURPOSE: To evaluate further the clinical utility of the interuncal distance (IUD) measured from axial MR scans as a reflection of hippocampal atrophy. METHODS: The IUD measured from the axial MR scans of 17 healthy control subjects was correlated with the ... Link to item Cite

Interuncal distance as a measure of hippocampal atrophy: normative data on axial MR imaging.

Journal Article AJNR Am J Neuroradiol · 1993 PURPOSE: To assess the effects of age and gender on the interuncal distance measured from MR images. METHODS: High-field strength MR images (axial) of 75 volunteers, 21-82 years old and free of neurologic disorders, were used to measure the interuncal dist ... Link to item Cite

Biology of social phobia

Journal Article European Neuropsychopharmacology · January 1, 1993 Full text Cite

The neurostructural/neurofunctional basis of depression/mania

Journal Article Current Opinion in Psychiatry · January 1, 1993 Full text Cite

Dose response relationship between plasma ACTH and cortisol after the infusion of ACTH1-24.

Journal Article Eur Arch Psychiatry Clin Neurosci · 1993 The authors examined the dose response relationship between plasma ACTH and cortisol concentrations after the administration of various doses of ACTH1-24 (0.025 micrograms, 0.125 micrograms, 0.25 micrograms, 1 microgram, 250 micrograms) in dexamethasone-su ... Full text Link to item Cite

In vivo quantitation of basal ganglia and thalamic degenerative changes in two temporal lobectomy patients with affective disorder.

Journal Article J Neuropsychiatry Clin Neurosci · 1993 The authors examined the brain magnetic resonance imaging scans of two epilepsy patients who had temporal lobectomies, one on the right and one on the left, with postoperative symptoms of affective disorders. Degenerative changes of ipsilateral thalamus an ... Full text Link to item Cite

Neuroanatomic substrates of depression in the elderly.

Journal Article J Geriatr Psychiatry Neurol · 1993 The causes of depression in the elderly are poorly understood. The concept that psychological and social factors are the primary contributors to the occurrence of depression in later life, though intuitively appealing, is not supported by available evidenc ... Full text Link to item Cite

Adrenal gland enlargement in major depression [2]

Journal Article Archives of General Psychiatry · 1993 Cite

The adrenal gland and depression [1]

Journal Article Archives of General Psychiatry · 1993 Cite

In vivo assessment of pituitary volume with magnetic resonance imaging and systematic stereology: relationship to dexamethasone suppression test results in patients.

Journal Article Psychiatry Res · October 1992 The relationship between dexamethasone suppression test (DST) results and in vivo pituitary volume was studied in 24 psychiatric inpatients. The principles of systematic stereology were used to measure pituitary volume from 3-mm contiguous sagittal spin-ec ... Full text Link to item Cite

Magnetic resonance imaging of the caudate nuclei in depression. Preliminary observations.

Journal Article Arch Gen Psychiatry · July 1992 A role of the caudate nucleus in depression has been suggested from relevant clinical conditions, such as patients with Huntington's disease or caudate infarcts, as well as animal studies. Correlations of caudate nucleus disease with depressive symptoms ha ... Full text Link to item Cite

Posterior fossa abnormalities in major depression: a controlled magnetic resonance imaging study.

Journal Article Acta Psychiatr Scand · June 1992 High-field magnetic resonance (MR) images were used to study posterior fossa morphology in 27 patients with major depression and 36 normal control subjects. Depressed patients demonstrated smaller brain stem and cerebellar vermis than controls. These diffe ... Full text Link to item Cite

Adrenal gland enlargement in major depression. A computed tomographic study.

Journal Article Arch Gen Psychiatry · May 1992 To determine whether the well-documented hyperactivity of the hypothalamic-pituitary-adrenal axis in depressed patients includes adrenal gland hypertrophy, adrenal gland size was evaluated by computed tomography. Assessments consisted of (1) global ratings ... Full text Link to item Cite

Subcortical brain anatomy in anorexia and bulimia.

Journal Article Biol Psychiatry · April 1, 1992 Full text Link to item Cite

Syndrome of inappropriate antidiuretic hormone secretion.

Journal Article J Clin Psychopharmacol · February 1992 Link to item Cite

Morphometric changes of the human midbrain with normal aging: MR and stereologic findings.

Journal Article AJNR Am J Neuroradiol · 1992 PURPOSE: To determine the effects of age on estimated midbrain volume. PATIENTS AND METHODS: T2-weighted MR imaging and an unbiased stereologic method were used in 75 volunteers; the subjects ranged in age from 21 to 82 years and were without any significa ... Link to item Cite

MR assessment of pituitary gland morphology in healthy volunteers: age- and gender-related differences.

Journal Article AJNR Am J Neuroradiol · 1992 PURPOSE AND METHODS: High-field MR images at 1.5 T were used to characterize the effects of age and gender on pituitary size and shape in a sample of 71 adult volunteers (40 females), aged 21 to 82 years. FINDINGS: For all subjects, age was inversely corre ... Link to item Cite

The treatment of late age onset psychoses with electroconvulsive therapy

Journal Article International Journal of Geriatric Psychiatry · January 1, 1992 The authors describe the clinical course and the brain imaging findings of six patients with late age onset psychoses who were treated with electroconvulsive therapy (ECT). In all five patients who failed to respond to ECT, one or more structural brain cha ... Full text Cite

RU486 in depression.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · 1992 RU486 is a synthetic glucocorticoid antagonist. The authors used RU486 to examine the hypothesis that the elevated plasma cortisol and ACTH in patients is due to suprahypophyseal stimulation of the anterior pituitary. Seven patients and matched controls we ... Full text Link to item Cite

Magnetic resonance in patients with affective illness.

Journal Article Eur Arch Psychiatry Clin Neurosci · 1992 Magnetic resonance imaging is presently being utilized to understand the neuropathology of affective disorders. Present research has demonstrated brain changes in affective disorders that correlate with neuroendocrine findings and are similar to changes no ... Full text Link to item Cite

Depression-Neuroanatomical substrates

Journal Article Behavior Therapy · January 1, 1992 Depressive disorders are treated by a variety of methods, psychological and physical. These treatments are considered to work by changing something fundamental in the brain (physical) or through psychological changes. Since the physical substrate of the ps ... Full text Cite

Long-Term Use of Benzodiazepines: Implications and guidelines.

Journal Article Can Fam Physician · January 1992 Problems associated with physical dependence and abuse of benzodiazepines by a small percentage of patients have reduced their popularity from the most commonly prescribed psychoactive drug in the 1970s to being prescribed for mainly short periods. Patient ... Link to item Cite

Occurrence of subcortical hyperintensities in elderly subjects with mania.

Journal Article Psychiatry Res · December 1991 In a retrospective study, brain magnetic resonance images of 12 patients with the onset of manic symptoms after the age of 50 years were compared to age- and sex-matched control subjects for the incidence, size, and location of subcortical hyperintensities ... Full text Link to item Cite

A magnetic resonance imaging study of putamen nuclei in major depression

Journal Article Psychiatry Research · December 1, 1991 The basal ganglia are recognized as putative mediators of certain cognitive and behavioral symptoms of major depression. Moreover, patients with basal ganglia lesions have repeatedly exhibited significant affective symptomatology, including apathy, depress ... Full text Cite

Levels of urinary free cortisol in social phobia.

Journal Article J Clin Psychiatry · November 1991 Levels of urinary free cortisol were measured in 10 patients with social phobias and in 15 age- and sex-matched normal controls. No differences were found either in cortisol levels or in the ratio of free cortisol to creatinine. These nonsignificant differ ... Link to item Cite

The Brief Social Phobia Scale.

Journal Article J Clin Psychiatry · November 1991 An observer measure of social phobic symptoms, referred to as the Brief Social Phobia Scale, consists of 11 items, 7 evaluating commonly feared or avoided situations and 4 additional items measuring autonomic distress. Symptoms represented by the scale ite ... Full text Link to item Cite

A magnetic resonance imaging study of putamen nuclei in major depression.

Journal Article Psychiatry Res · October 1991 The basal ganglia are recognized as putative mediators of certain cognitive and behavioral symptoms of major depression. Moreover, patients with basal ganglia lesions have repeatedly exhibited significant affective symptomatology, including apathy, depress ... Full text Link to item Cite

MRI quantification.

Journal Article Neurology · June 1991 Full text Link to item Cite

MRI quantification.

Journal Article Neurology · June 1, 1991 Cite

Obsessive Compulsive Disorder: Improving prognosis through therapy and drug treatment.

Journal Article Can Fam Physician · June 1991 An estimated three to seven million Americans suffer from obsessive compulsive disorder at some time in their lives. Until recently, obsessive compulsive disorder was considered refractory to most treatments. However, recent studies indicate a better progn ... Link to item Cite

Magnetic resonance findings in patients with early-onset Alzheimer's disease.

Journal Article Biol Psychiatry · April 15, 1991 The magnetic resonance scans of 22 patients with early-onset Alzheimer's disease (AD) were compared to 16 age-matched neurologically normal controls for the presence of white matter subcortical hyperintensities (SCH) and periventricular hyperintensities (P ... Full text Link to item Cite

Synthesis of [11C]citalopram and brain distribution studies in rats

Journal Article Journal of Labelled Compounds and Radiopharmaceuticals · April 5, 1991 Cite

Platelet [3H]-imipramine binding and leukoencephalopathy in geriatric depression.

Journal Article Biol Psychiatry · April 1, 1991 We examined the relationship between platelet [3H]-imipramine binding and leukoencephalopathy as assessed by 1.5 Tesla Magnetic Resonance Imaging (MRI) in 21 elderly depressed patients who satisfied DSM-III criteria for major depression. Both drug-free pla ... Full text Link to item Cite

Pituitary size in depression.

Journal Article J Clin Endocrinol Metab · February 1991 Magnetic resonance images centered at the pituitary stalk were used to measure pituitary gland size in 19 patients with major depression compared with that in age- and sex-matched controls. Depressed patients had significantly greater pituitary cross-secti ... Full text Link to item Cite

A magnetic resonance image study of age-related changes in human putamen nuclei.

Journal Article Neuroreport · January 1991 Putamen nuclei were assessed in 36 normal volunteers using magnetic resonance imaging and a systematic sampling method. There was a significant decrease in the volume of the putamen nuclei with advancing age (r = -0.74, p less than 0.0001), and an associat ... Full text Link to item Cite

Caudate hyperintensities in elderly depressed patients with neuroleptic-induced parkinsonism.

Journal Article J Geriatr Psychiatry Neurol · 1991 Elderly patients are particularly sensitive to the neurologic side effects of psychotropic medications. This increased sensitivity may be related to brain structural changes associated with aging. In this pilot study, the authors report on the occurrence o ... Full text Link to item Cite

Hippocampal abnormalities in depression.

Journal Article J Neuropsychiatry Clin Neurosci · 1991 A quantitative magnetic resonance imaging study of regional brain T1 spin-lattice relaxation times in 29 normal volunteers and in 20 patients with major depression revealed significantly shortened T1 relaxation times for the hippocampus in depressed patien ... Full text Link to item Cite

In vivo stereological assessment of human cerebellar volume: effects of gender and age.

Journal Article AJNR Am J Neuroradiol · 1991 Intermediate T2-weighted MR images and a systematic sampling stereological method were used in 37 normal volunteers, 24 to 79 years old, to assess the effects of age and sex on cerebellar volume. Female subjects (n = 21) had significantly smaller cerebella ... Link to item Cite

Magnetic resonance imaging in biological psychiatry.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · 1991 1. Although clinicians have been quick to adopt magnetic resonance imaging (MRI) in the search for brain pathology in psychiatric disorders, the clinical utility of MRI is only now being well defined. 2. Numerous past computerized tomography or post-mortem ... Full text Link to item Cite

Pituitary abnormalities in eating disorders: further evidence from MRI studies.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · 1991 1. The frequent occurrence of hypothalamo-pituitary dysfunction in patients with eating disorders as well as prior reports that nutritional and endocrine status influence pituitary morphology, led us to hypothesize that pituitary size and shape may be alte ... Full text Link to item Cite

Assessment of posterior fossa structures with midsagittal MRI: the effects of age.

Journal Article Neurobiol Aging · 1991 Midsagittal magnetic resonance (MR) images of 36 normal volunteers, ranging in age from 26 to 79 years, were used to evaluate the effects of age on the size of posterior fossa structures (cerebellar vermis, midbrain, pons, medulla and fourth ventricle). Ou ... Full text Link to item Cite

Subcortical hyperintensities on brain magnetic resonance imaging: a comparison between late age onset and early onset elderly depressed subjects.

Journal Article Neurobiol Aging · 1991 Subcortical structural changes have been reported to occur in some elderly subjects with late age onset depression. Given the association between diseases affecting subcortical structures and affective disorders, this suggests that these structural changes ... Full text Link to item Cite

Aging of the human corpus callosum: magnetic resonance imaging in normal volunteers.

Journal Article J Neuropsychiatry Clin Neurosci · 1991 A brain magnetic resonance imaging (MRI) study of the corpus callosum in 36 normal volunteers, ages 26-79 years, revealed that age was positively correlated with the T1 spin-lattice relaxation time of the corpus callosum and was negatively correlated with ... Full text Link to item Cite

ECT-induced delirium in depressed patients with Parkinson's disease.

Journal Article J Neuropsychiatry Clin Neurosci · 1991 In this pilot study, a prolonged (interictal) delirium was induced by electroconvulsive therapy (ECT) in seven out of seven depressed patients with Parkinson's disease. This occurrence of delirium appears much higher than what has been reported in other pa ... Full text Link to item Cite

Subcortical hyperintensities on brain magnetic resonance imaging: a comparison of normal and bipolar subjects.

Journal Article J Neuropsychiatry Clin Neurosci · 1991 Bipolar disorder has been reported to occur frequently in a number of subcortical diseases. This suggests that subcortical structures may be involved in the etiology of bipolar disorder in some patients. With the advent of brain magnetic resonance imaging ... Full text Link to item Cite

Role of serotonin in hypothalamo pituitary adrenal axis escape from dexamethasone suppression.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · 1991 1. The authors investigated the role of serotonin in the hypothalamo pituitary adrenal escape from depression. 2. Maximal dose of fenfluramine was administered to normal individuals pretreated with dexamethasone. 3. Fenfluramine had only a minimal and inco ... Full text Link to item Cite

Fast feedback regulation of ACTH by cortisol.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · 1991 1. Fast feedback regulation of ACTH by cortisol has not been well studied in humans. The authors studied the existence and characteristics of fast feedback regulation in normal humans. 2. Hydrocortisone hemisuccinate was infused at two different rates: 6 m ... Full text Link to item Cite

PITUITARY CHANGES IN DEPRESSION

Conference BIOLOGICAL PSYCHIATRY, VOL 1 · January 1, 1991 Link to item Cite

Organic bases of depression in the elderly.

Journal Article Annu Rev Med · 1991 Early studies suggested that cerebrovascular change may be an etiological factor in the development of late-life depression. With the advent of magnetic resonance imaging (MRI), it has become possible to examine this hypothesis. MRI studies have demonstrat ... Full text Link to item Cite

Occult subcortical magnetic resonance findings in elderly depressives

Journal Article International Journal of Geriatric Psychiatry · January 1, 1991 Hyperintense signal areas (HSA) on T2‐weighted brain magnetic resonance imaging (MRI) may reflect subtle cerebrovascular insufficiency and are common in elderly depressives. We hypothesized that these HSAs may indicate a vascular etiology for depression in ... Full text Cite

Brain imaging and psychiatric disorders

Journal Article Current Opinion in Psychiatry · September 5, 1990 Full text Cite

In vivo assessment of pituitary gland volume with magnetic resonance imaging: the effect of age.

Journal Article J Clin Endocrinol Metab · August 1990 We used sagittal and coronal T1 weighted magnetic resonance images, at 1.5 Tesla, to measure the height, width, length, and cross-sectional area and to generate two estimates of pituitary gland volume in 35 normal volunteers aged 26-79 yr (19 females and 1 ... Full text Link to item Cite

Cerebral white matter disease in late-onset paranoid psychosis.

Journal Article Biol Psychiatry · August 1, 1990 We examined magnetic resonance (MR) scans of the heads of 8 patients with late onset psychosis and 8 aged controls. Although some patients had mild cognitive impairment, none had depression or a history or examination suggesting focal brain disease. Thus, ... Full text Link to item Cite

A brain magnetic resonance imaging study of pituitary gland morphology in anorexia nervosa and bulimia.

Journal Article Biol Psychiatry · July 15, 1990 Magnetic resonance imaging (MRI) of the brain was used to examine the morphology and dimensions of the pituitary gland in 18 patients with eating disorders (8 anorectics and 10 bulimics), in comparison with 13 healthy volunteers. None of the 18 patients wi ... Full text Link to item Cite

Nocturnal and early morning secretion of ACTH and cortisol in humans.

Journal Article Biol Psychiatry · July 1, 1990 It is well established that the adrenocorticotropic hormone (ACTH) stimulates the synthesis and release of cortisol from the adrenal cortex, but the role of ACTH in the physiological regulation of basal cortisol secretion has received surprisingly little s ... Full text Link to item Cite

Pharmacologic management of the symptoms of dementia.

Journal Article Am Fam Physician · July 1990 Many patients with dementia have symptoms of depression and agitation in addition to the underlying cognitive impairment. These symptoms can be management problems for both the physician and the caregiver. In many cases, however, pharmacologic intervention ... Link to item Cite

SYNTHESIS AND BRAIN DISTRIBUTION OF (C-11) CITALOPRAM, A LIGAND FOR EVALUATION OF SEROTONIN UPTAKE SITES

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · April 22, 1990 Link to item Cite

Elevated plasma concentrations of alpha 1-acid glycoprotein, a putative endogenous inhibitor of the tritiated imipramine binding site, in depressed patients.

Journal Article Arch Gen Psychiatry · April 1990 The plasma concentration of alpha 1-acid glycoprotein, a putative endogenous inhibitor of the site labeled by tritiated imipramine, was measured by a radial immunodiffusion assay in 36 normal human volunteers and 51 drug-free patients who fulfilled DSM-III ... Full text Link to item Cite

Plasma dexamethasone concentrations and the dexamethasone suppression test.

Journal Article Biol Psychiatry · January 15, 1990 Altered bioavailability or altered pharmacokinetics of dexamethasone (dex) may contribute to a positive Dexamethasone Suppression Test (DST) in psychiatric patients. We measured plasma dex and plasma cortisol concentrations in 32 patients with primary majo ... Full text Link to item Cite

Subcortical structural changes in ECT-induced delirium.

Journal Article J Geriatr Psychiatry Neurol · 1990 A prolonged (interictal) delirium was induced by electroconvulsive therapy (ECT) in 6/36 (17%) elderly depressed patients. Brain magnetic resonance imaging or brain computerized axial tomography revealed structural changes in the basal ganglia and white ma ... Full text Link to item Cite

In vivo stereological assessment of caudate volume in man: effect of normal aging.

Journal Article Life Sci · 1990 Using intermediate weighted magnetic resonance imaging (MRI) and a systematic sampling stereological method in 39 normal volunteers aged 24-79 years old, we demonstrated a marked age-associated decline in caudate nuclei volume (r = -0.69, p less than 0.000 ... Full text Link to item Cite

Differential diagnosis and pathophysiology of Cushing's syndrome and primary affective disorder.

Journal Article J Neuropsychiatry Clin Neurosci · 1990 Most patients with major depression have increased 24-hour urinary free cortisol and cortisol nonsuppression after dexamethasone administration, which are cornerstones of a diagnosis of Cushing's syndrome. Similarly, Cushing's syndrome patients often suffe ... Full text Link to item Cite

Psychiatric syncope: a new look at an old disease.

Journal Article Psychosomatics · 1990 Psychiatric disorders in patients with unexplained syncope or presyncope have received little attention in the recent medical literature. Seventy-two patients with unexplained syncope and presyncope referred to the Duke Syncope Clinic received a standardiz ... Link to item Cite

Pharmacokinetics of growth hormone secretion in humans induced by growth hormone releasing hormone.

Journal Article Life Sci · 1990 This investigation compares the age- and sex-related changes in growth hormone (GH) response to growth hormone releasing hormone (GHRH) in normal subjects using an appropriate pharmacokinetic model. Twenty-five subjects (14 males and 11 females) aged 23-89 ... Full text Link to item Cite

Growth hormone response to growth hormone releasing factor in Alzheimer's disease.

Journal Article Neuroendocrinology · December 1989 Because of the well-established reduction in the concentration of somatostatin in several brain areas of patients with histologically verified Alzheimer's disease, we sought to determine if growth hormone (GH) secretion is altered in Alzheimer's disease. I ... Full text Link to item Cite

Antidepressants in chronic pain syndromes.

Journal Article Am Fam Physician · April 1989 Antidepressants are often effective in the management of chronic pain syndromes. They are most useful for certain types of pain complaints, such as headache, diabetic neuropathy, arthritis and facial pain. The choice of antidepressant depends on the side e ... Link to item Cite

Reduced inhibitory effect of imipramine on radiolabeled serotonin uptake into platelets in geriatric depression.

Journal Article Biol Psychiatry · March 15, 1989 Tritiated imipramine binding, uptake of radiolabeled serotonin, and inhibition of uptake by imipramine in vitro were studied in platelets obtained from four groups of subjects: (1) normal controls 50 years of age or younger, (2) patients with major depress ... Full text Link to item Cite

Radiologic correlates of antidepressant-induced delirium: the possible significance of basal-ganglia lesions.

Journal Article J Neuropsychiatry Clin Neurosci · 1989 Antidepressant-induced delirium in five of 60 (8%) patients over the age of 45 is reported. In each case, delirium developed within two weeks of beginning the antidepressant and appeared to be completely reversible once the medication was discontinued. Bra ... Full text Link to item Cite

MRI scans in patients with tardive dyskinesia.

Journal Article Biol Psychiatry · November 1988 Full text Link to item Cite

Marked reduction in the number of platelet-tritiated imipramine binding sites in geriatric depression.

Journal Article Arch Gen Psychiatry · October 1988 The number (Bmax) and affinity (Kd) of platelet-tritiated imipramine binding sites was determined in young and middle-aged controls 50 years of age and younger (n = 25), elderly normal controls over 60 years of age (n = 18), patients who fulfilled DSM-III ... Full text Link to item Cite

Structural brain changes revealed by MRI.

Journal Article Am J Psychiatry · October 1988 Full text Link to item Cite

Circadian rhythm of adrenergic regulation of adrenocorticotropin and cortisol secretion in man.

Journal Article J Clin Endocrinol Metab · August 1988 The effects of the alpha-adrenergic agonist methoxamine on the human hypothalamic-pituitary-adrenal axis was assessed by a placebo-controlled study in the morning and one in the evening. A 5-mg iv bolus dose of methoxamine in normal subjects caused a signi ... Full text Link to item Cite

Adrenocortical sensitivity to ACTH in humans.

Journal Article Biol Psychiatry · May 1988 Full text Link to item Cite

Subtypes of depression in patients with chronic pain.

Journal Article South Med J · April 1988 Recent studies have shown that depression can be assessed in patients who have chronic pain. This study shows that various subtypes of depression can be differentiated in such patients using a standardized diagnostic schema for psychiatric disorders and a ... Full text Link to item Cite

A study of depressive typologies using grade of membership analysis.

Journal Article Psychol Med · February 1988 Grade of Membership (GOM) analysis, a multivariate technique for studying disease, was used to explore depressive typology and relationships between depression and anxiety. One hundred and ninety patients with RDC diagnoses of major or minor depression wer ... Full text Link to item Cite

Growth hormone-releasing factor stimulation test in depression.

Journal Article Am J Psychiatry · January 1988 The authors administered the growth hormone-releasing factor (GRF) stimulation test to 19 patients with major depression and 19 age- and sex-matched control subjects to test the hypothesis that a blunted growth hormone (GH) response to clonidine reflects a ... Full text Link to item Cite

Growth hormone response to growth hormone-releasing factor in depression.

Journal Article Peptides · 1988 A blunted growth hormone (GH) response to clonidine and other pharmacologic stimuli has been reported in patients with depression. This blunted growth hormone response to clonidine has led to the speculation that there is a central alpha-2 adrenergic recep ... Full text Link to item Cite

Effects of gamma-interferon on the endocrine system: results from a phase I study.

Journal Article Cancer Res · December 1, 1987 Interferon causes profound biological changes when given to patients with cancer and many of these could not be predicted from in vitro or animal model systems. We documented significant changes in hormonal levels for a group of 18 patients who were partic ... Link to item Cite

Diagnostic utility of the dexamethasone suppression test.

Journal Article Biol Psychiatry · May 1987 This article discusses the current controversy surrounding the diagnostic utility of the Dexamethasone Suppression Test, addresses the questions raised by the recent editorial by Ross in this journal, discusses the general principles behind the development ... Full text Link to item Cite

Chronic pain and depression.

Journal Article South Med J · May 1987 Patients with chronic pain syndromes often have concomitant depression. In this paper we discuss the clinical and biologic characteristics of depression, and also briefly discuss the various subtypes of depression, potential modes in the development of dep ... Full text Link to item Cite

Failure of long term high-dose lecithin to retard progression of early-onset Alzheimer's disease.

Journal Article J Neural Transm Suppl · 1987 We conducted a six-month, randomized, double-blind trial of lecithin therapy in early-onset Alzheimer's disease. We hypothesized that such therapy would retard the progression of the clinical and neuropsychological manifestations of this illness. Of the 73 ... Link to item Cite

PHYSIOLOGY OF HUMAN HPA REGULATION IN DEPRESSION

Conference INTERNATIONAL JOURNAL OF NEUROSCIENCE · January 1, 1987 Link to item Cite

Chronic pain and depression. IV. DST as a discriminator between chronic pain and depression.

Journal Article Pain · January 1987 In an attempt to clarify the relationship between chronic pain and depression, the authors studied the plasma cortisol response to dexamethasone in a group of 73 consecutive chronic low back pain patients admitted to a pain unit and 34 consecutive patients ... Full text Link to item Cite

MONOAMINE METABOLITES IN CHRONIC PAIN AND DEPRESSION

Conference INTERNATIONAL JOURNAL OF NEUROSCIENCE · January 1, 1987 Link to item Cite

The utility of the dexamethasone suppression test.

Journal Article Arch Gen Psychiatry · January 1987 Full text Link to item Cite

Preliminary study of thyrotrophin releasing hormone stimulation test in chronic low back pain patients.

Journal Article Pain · October 1986 Chronic pain has been considered as a variant of depression or as a masked depression. In an attempt to unravel the complex relationship between chronic pain and depression, we administered the TRH stimulation test to a uniform group of chronic pain patien ... Full text Link to item Cite

CLINICAL CHARACTERISTICS OF DEPRESSION SUBTYPES IN CHRONIC PAIN PATIENTS

Conference SOUTHERN MEDICAL JOURNAL · September 1, 1986 Link to item Cite

An assessment of the Newcastle Anxiety Depression Index.

Journal Article Acta Psychiatr Scand · May 1986 The Newcastle Anxiety and Depression Diagnostic Index (NADDI) has been reviewed, and its advantages and disadvantages discussed. One hundred eighty-seven patients were examined, and grouped into three categories by means of the NADDI, which produced a unim ... Full text Link to item Cite

Chronic pain and depression. III. Family history study of depression and alcoholism in chronic low back pain patients.

Journal Article Pain · February 1986 In an attempt to unravel the relationship between chronic pain and depression, the authors studied the incidence of depression, alcoholism, and chronic pain in first degree relatives of 100 chronic pain patients with and without depression. A higher incide ... Full text Link to item Cite

Depression as a psychopathological disorder in chronic low back pain patients.

Journal Article J Psychosom Res · 1986 An association between chronic pain and depression has been recognised for a long time. However, the exact nature of this association remains unclear. The authors studied 80 consecutive patients with chronic low back pain. Different types of depression wer ... Full text Link to item Cite

Response

Journal Article Biological Psychiatry · January 1, 1986 Full text Cite

Chronic pain in psychiatric [correction of psychotic] patients.

Journal Article The American journal of psychiatry · 1986 Cite

Response

Journal Article Biological Psychiatry · 1986 Cite

The Newcastle Anxiety Depression Diagnostic Index in relationship to the effects of monoamine oxidase inhibitors and tricyclic antidepressants.

Journal Article J Affect Disord · 1986 The Newcastle Anxiety Depression Diagnostic Index (NADDI) was applied to 151 patients who received a monoamine oxidase inhibitor (MAOI) or a tricyclic antidepressant (TCA) drug. The pretreatment presence of a physical stressor and absence of agoraphobia we ... Full text Link to item Cite

Neurovegetative symptoms in chronic pain and depression.

Journal Article J Affect Disord · November 1985 The pattern and frequency of neurovegetative symptoms was studied in 57 patients with chronic pain. Seventy-nine percent of these patients had a diagnosable depressive illness, but endogenous depression was rare (5%). Patients with chronic pain were divide ... Full text Link to item Cite

What does the dexamethasone suppression test identify?

Journal Article Biol Psychiatry · September 1985 The authors studied the Dexamethasone Suppression Test (DST) in chronic pain patients with and without major depression, using items from a modified version of the Hamilton Depression Scale, the Hamilton Anxiety Scale, and the Montgomery-Asberg Depression ... Full text Link to item Cite

Weight change and the dexamethasone suppression test.

Journal Article Biol Psychiatry · September 1985 Full text Link to item Cite

Chronic pain and depression. I. Classification of depression in chronic low back pain patients.

Journal Article Pain · July 1985 An association between chronic pain and depression has been recognized for a long time. However, the exact nature of this relationship remains unclear. The authors studied 71 patients for affective disorders and schizophrenia-lifetime version (SADS-L). Bas ... Full text Link to item Cite

Chronic pain and depression. II. Symptoms of anxiety in chronic low back pain patients and their relationship to subtypes of depression.

Journal Article Pain · July 1985 The relationship between anxiety and chronic pain has been poorly studied. The authors studied the occurrence of symptoms of anxiety in chronic low back pain patients. Anxious mood and other symptoms of anxiety were commonly seen in patients with chronic l ... Full text Link to item Cite

Chronic low back pain and depression.

Journal Article Psychosomatics · April 1985 Full text Link to item Cite

A diagnostic and family study of posttraumatic stress disorder.

Journal Article Am J Psychiatry · January 1985 A family history study of 36 patients with chronic posttraumatic stress disorder revealed a positive history of familial psychopathology in 66% of the patients. Alcoholism, depression, and anxiety disorders were the disorders most commonly found. The patie ... Full text Link to item Cite

Trichotillomania--a review.

Journal Article Compr Psychiatry · 1985 Full text Link to item Cite

The dexamethasone suppression test as a biologic marker of depression in chronic pain.

Journal Article Pain · January 1985 The relationship between chronic pain and depression has become enmeshed in the literature. In an attempt to unravel the relationship between chronic pain and depression, the authors studied a uniform group of 80 chronic back pain patients with and without ... Full text Link to item Cite

Differentiation of depression from chronic pain with the dexamethasone suppression test and DSM-III.

Journal Article Am J Psychiatry · December 1984 The concept of chronic pain has become enmeshed with depression. In an attempt to unravel this complex relationship, the authors studied a uniform group of 42 patients with chronic pain, i.e., patients who had chronic low back pain with defined organic pat ... Full text Link to item Cite

Alprazolam-induced manic reaction.

Journal Article Am J Psychiatry · September 1984 Link to item Cite

The interictal EEG in diagnosis of epilepsy.

Journal Article Lancet · September 1, 1984 Full text Link to item Cite

Funeral mania in recurrent bipolar affective disorders: reports of three cases.

Journal Article J Clin Psychiatry · July 1984 Anniversary reactions as precipitants of manic episodes are reported to be relatively common, while manic onset within a week of bereavement ("funeral mania") has been considered rare. Three cases of funeral mania are described to illustrate that this phen ... Link to item Cite

MAO inhibitor therapy in trichotillomania associated with depression: case report.

Journal Article J Clin Psychiatry · June 1984 Trichotillomania may sometimes be an atypical variant of depressive illness. A case is reported in which the MAO inhibitor isocarboxazid was successfully used to treat both depression and associated trichotillomania. The symptoms recurred upon discontinuat ... Link to item Cite

Dreams of flying in narcoleptic patients.

Journal Article Psychosomatics · May 1984 Full text Link to item Cite

Tricyclic-induced akathisia in patients taking conjugated estrogens.

Journal Article Am J Psychiatry · May 1984 Three patients taking conjugated estrogens developed akathisia induced by tricyclic antidepressants. The interaction between tricyclic antidepressants and conjugated estrogens could play a role in the development of akathisia. ... Full text Link to item Cite

Effects of single and repeated alcohol withdrawal on kindling.

Journal Article Biol Psychiatry · April 1984 It has been hypothesized that an electrophysiological reorganization of the limbic system takes place with repeated episodes of alcohol withdrawal which leaves the individual more susceptible to withdrawal effects, including delirium tremens and seizures. ... Link to item Cite

Narcolepsy: preliminary retrospective study of psychiatric and psychosocial aspects.

Journal Article Am J Psychiatry · March 1984 A review of the charts of 24 ambulatory male veterans with narcolepsy or narcolepsy/cataplexy showed an impressive number of psychiatric and psychosocial difficulties in these patients, such as poor adjustment to the illness, high unemployability, and dist ... Full text Link to item Cite

Behavioral toxicity with alprazolam

Journal Article Journal of Clinical Psychopharmacology · January 1, 1984 Full text Cite

Funeral mania in recurrent bipolar affective disorders: Reports of three cases

Journal Article Journal of Clinical Psychiatry · January 1, 1984 Anniversity reactions as precipitants of manic episodes are reported to be relatively common, while manic onset within a week of bereavement ('funeral mania') has been considered rare. Three cases of funeral mania are described to illustrate that this phen ... Cite

DELIRIUM AND TRICYCLIC ANTIDEPRESSANTS - REPLY

Journal Article AMERICAN JOURNAL OF PSYCHIATRY · January 1, 1984 Link to item Cite

Deep-vein thrombosis with antipsychotic drugs.

Journal Article Psychosomatics · December 1983 Full text Link to item Cite

Alprazolam for endogenous depression.

Journal Article Am J Psychiatry · May 1983 Full text Link to item Cite

Abnormal cortisol suppression in bipolar patients with simultaneous manic and depressive symptoms.

Journal Article Am J Psychiatry · February 1983 The authors studied the cortisol response to 1 mg of dexamethasone in 10 patients who simultaneously manifested manic and depressive symptoms. All patients showed some evidence that normal cortisol suppression was lacking. When 3 patients were randomly ret ... Full text Link to item Cite

Treatment of spasmodic torticollis with ethyl chloride.

Journal Article J Clin Psychopharmacol · August 1982 Full text Link to item Cite

Letters to the editors

Journal Article Journal of Clinical Psychopharmacology · January 1, 1982 Cite