Scholars@Duke
Matthew L Becker

Matthew L Becker

Hugo L. Blomquist Distinguished Professor of Chemistry
Chemistry
matthew.l.becker@duke.edu
B120 Levine Science Res Center, 308 Research Drive, Durham, NC 27708
B120 Levine Science Res Center, 308 Research Drive, Durham, NC 27708

Selected Publications

Synthesis and Solvent Free DLP 3D Printing of Degradable Poly(Allyl Glycidyl Ether Succinate)

Journal Article Angewandte Chemie - International Edition · January 10, 2025 Digital light processing (DLP) printing forms solid constructs from fluidic resins by photochemically crosslinking polymeric resins with reactive functional groups. DLP is used widely due to its efficient, high-resolution printing, but its use and translat ... Full text Cite

Pre-Clinical Assessment of Bupivacaine-Loaded Poly(ester urea) Thin Films for Controlled Drug Release and Effective Pain Management After Surgery.

Journal Article Adv Healthc Mater · December 12, 2024 Safe, effective pain management remains one of the biggest challenges following surgical procedures. Despite widespread recognition of this problem and advances in the mechanistic understanding of pain signaling, post-surgical pain is often undermanaged, w ... Full text Link to item Cite

Controlled Transdermal Delivery of Dexamethasone for Pain Management via Photochemically 3D-Printed Bioresorbable Microneedle Arrays.

Journal Article Adv Healthc Mater · December 2024 Microneedle array patches (MAPs) are extensively studied for transdermal drug delivery. Additive manufacturing enables precise control over MAP customization and rapid fabrication. However, the scope of 3D-printable, bioresorbable materials is limited. Dex ... Full text Link to item Cite

Semiaromatic Polyester-Ethers with Tunable Degradation Profiles.

Journal Article ACS macro letters · November 2024 Poly(ε-caprolactone) (PCL) is a widely utilized polymer within the biomedical field; however, one of its limitations is the multi-year long degradation profile. Herein, we report a semiaromatic polyester-ether (SAEE) PCL copolymer using a salicylic acid-ba ... Full text Cite

Amino Acid-Based Poly(ester urea) Biodegradable Membrane for Guided Bone Regeneration.

Journal Article ACS applied materials & interfaces · October 2024 Barrier membranes (BM) for guided bone regeneration (GBR) aim to support the osteogenic healing process of a defined bony defect by excluding epithelial (gingival) ingrowth and enabling osteoprogenitor and stem cells to proliferate and differentiate into b ... Full text Cite

Platelet-rich plasma enhances rib fracture strength and callus formation in vivo.

Journal Article J Trauma Acute Care Surg · September 6, 2024 BACKGROUND: Rib fractures are a common traumatic injury affecting more than 350,000 patients a year. Early stabilization has shown to be effective in reducing pulmonary complications. Platelet-rich plasma (PRP) is a growth factor-rich blood product known t ... Full text Link to item Cite

Poly(ester urea)s: Synthesis, material properties, and biomedical applications

Journal Article Progress in Polymer Science · September 1, 2024 Amino acid-based poly(ester urea)s (PEUs) are an emerging class of highly tunable, degradable polymers that have found utility in a wide scope of biomedical applications. PEUs possess three points of tunability at the amino acid side chain, diol length, an ... Full text Cite

Digital Light Processing to Afford High Resolution and Degradable CO2-Derived Copolymer Elastomers.

Journal Article Angewandte Chemie (International ed. in English) · August 2024 Vat photopolymerization 3D printing has proven very successful for the rapid additive manufacturing (AM) of polymeric parts at high resolution. However, the range of materials that can be printed and their resulting properties remains narrow. Herein, we re ... Full text Cite

Microfluidic Assembly of Degradable, Stereocomplexed Hydrogel Microparticles.

Journal Article Journal of the American Chemical Society · May 2024 Hydrogel microparticles (HMPs) have been investigated widely for their use in tissue engineering and drug delivery applications. However, translation of these highly tunable systems has been hindered by covalent cross-linking methods within microparticles. ... Full text Cite

Factors affecting product association as a mechanism of host-cell protein persistence in bioprocessing.

Journal Article Biotechnology and bioengineering · April 2024 Product association of host-cell proteins (HCPs) to monoclonal antibodies (mAbs) is widely regarded as a mechanism that can enable HCP persistence through multiple purification steps and even into the final drug substance. Discussion of this mechanism ofte ... Full text Cite

Thiol-ene-Based 3D Printing of Bioresorbable Fumarate-Based ABA Triblock Copolyester Elastomers

Journal Article Advanced Materials Technologies · December 13, 2023 Additive manufacturing continues to evolve as a powerful tool for the fabrication of tissue-engineered scaffolds and medical devices. With this evolution, a library of materials with a broad range of mechanical properties and degradation behaviors is neede ... Full text Cite

Application of surface-layer matrix-assisted laser desorption/ionization mass spectrometry imaging to pharmaceutical-loaded poly(ester urea) films.

Journal Article Analytica chimica acta · December 2023 Polymer thin films are often used in transdermal patches as a method of continuous drug administration for patients with chronic illness. Understanding the drug segregation and distribution within these films is important for monitoring proper drug release ... Full text Cite

Resorbable barrier polymers for flexible bioelectronics.

Journal Article Nature communications · November 2023 Resorbable, implantable bioelectronic devices are emerging as powerful tools to reliably monitor critical physiological parameters in real time over extended periods. While degradable magnesium-based electronics have pioneered this effort, relatively short ... Full text Cite

Mechanochromism and Strain-Induced Crystallization in Thiol-yne-Derived Stereoelastomers.

Journal Article Advanced materials (Deerfield Beach, Fla.) · October 2023 Most elastomers undergo strain-induced crystallization (SIC) under tension; as individual chains are held rigidly in a fixed position by an applied strain, their alignment along the strain field results in a shift from strain-hardening (SH) to SIC. A simil ... Full text Open Access Cite

Applied machine learning as a driver for polymeric biomaterials design.

Journal Article Nature communications · August 2023 Polymers are ubiquitous to almost every aspect of modern society and their use in medical products is similarly pervasive. Despite this, the diversity in commercial polymers used in medicine is stunningly low. Considerable time and resources have been exte ... Full text Cite

Calcium Trimetaphosphate-Loaded Electrospun Poly(Ester Urea) Nanofibers for Periodontal Tissue Engineering

Journal Article Journal of Functional Biomaterials · July 1, 2023 The objective of this research was to create and appraise biodegradable polymer-based nanofibers containing distinct concentrations of calcium trimetaphosphate (Ca-TMP) for periodontal tissue engineering. Poly(ester urea) (PEU) (5% w/v) solutions containin ... Full text Cite

Anti-adhesive bioresorbable elastomer-coated composite hernia mesh that reduce intraperitoneal adhesions.

Journal Article Biomaterials · January 2023 Intraperitoneal adhesions (IAs) are a major complication arising from abdominal repair surgeries, including hernia repair procedures. Herein, we fabricated a composite mesh device using a macroporous monofilament polypropylene mesh and a degradable elastom ... Full text Link to item Cite

Quantification of cell migration: metrics selection to model application.

Journal Article Frontiers in cell and developmental biology · January 2023 Cell migration plays an essential role in physiological and pathological states, such as immune response, tissue generation and tumor development. This phenomenon can occur spontaneously or it can be triggered by an external stimuli, including biochemical, ... Full text Cite

Ionic dielectrics for fully printed carbon nanotube transistors: impact of composition and induced stresses.

Journal Article Nanoscale · November 2022 Printed carbon nanotube thin-film transistors (CNT-TFTs) are candidates for flexible electronics with printability on a wide range of substrates. Among the layers comprising a CNT-TFT, the gate dielectric has proven most difficult to additively print owing ... Full text Cite

A Synthetic Hydrogel Composite with a Strength and Wear Resistance Greater than Cartilage

Journal Article Advanced Functional Materials · October 1, 2022 Key hurdles for replacing damaged cartilage with an equivalent synthetic construct are the development of a hydrogel with a strength that exceeds that of cartilage and fixation of this hydrogel onto the surface of an articulating joint. This article descri ... Full text Cite

High-speed, scanned laser structuring of multi-layered eco/bioresorbable materials for advanced electronic systems.

Journal Article Nature communications · October 2022 Physically transient forms of electronics enable unique classes of technologies, ranging from biomedical implants that disappear through processes of bioresorption after serving a clinical need to internet-of-things devices that harmlessly dissolve into th ... Full text Cite

Thiol-Based Three-Dimensional Printing of Fully Degradable Poly(propylene fumarate) Star Polymers.

Journal Article ACS applied materials & interfaces · August 2022 Poly(propylene fumarate) star polymers photochemically 3D printed with degradable thiol cross-linkers yielded highly tunable biodegradable polymeric materials. Tailoring the alkene:thiol ratio (5:1, 10:1, 20:1 and 30:1) and thus the cross-link density with ... Full text Cite

Degradable, Photochemically Printable Poly(propylene fumarate)-Based ABA Triblock Elastomers.

Journal Article Biomacromolecules · June 2022 Additive manufacturing is rapidly advancing tissue engineering, but the scope of its clinical translation is limited by a lack of materials designed to meet specific mechanical properties and resorption timelines. Materials that are printable via photochem ... Full text Cite

Influence of Touch-Spun Nanofiber Diameter on Contact Guidance during Peripheral Nerve Repair.

Journal Article Biomacromolecules · June 2022 Peripheral nerve regeneration across large gaps remains clinically challenging and scaffold design plays a key role in nerve tissue engineering. One strategy to encourage regeneration has utilized nanofibers or conduits to exploit contact guidance within t ... Full text Cite

Reassessing Undergraduate Polymer Chemistry Laboratory Experiments for Virtual Learning Environments.

Journal Article Journal of chemical education · May 2022 Chemistry laboratory experiments are invaluable to students' acquisition of necessary synthetic, analytical, and instrumental skills during their undergraduate studies. However, the COVID-19 pandemic rendered face-to-face (f2f), in-person teaching laborato ... Full text Cite

Gradient versus End-Capped Degradable Polymer Sequence Variations Result in Stiff to Elastic Photochemically 3D-Printed Substrates.

Journal Article Biomacromolecules · May 2022 Additive manufacturing affords the construction of complex scaffolds for tissue engineering, yet the limitation in material choice remains a barrier to clinical translation. Herein, a series of poly(propylene fumarate-co-propylene succinate) were sy ... Full text Cite

Ultra-Tough Elastomers from Stereochemistry-Directed Hydrogen Bonding in Isosorbide-Based Polymers.

Journal Article Angewandte Chemie (International ed. in English) · April 2022 The remarkable elasticity and tensile strength found in natural elastomers are challenging to mimic. Synthetic elastomers typically feature covalently cross-linked networks (rubbers), but this hinders their reprocessability. Physical cross-linking via hydr ... Full text Cite

Shape Memory Behavior of Biocompatible Polyurethane Stereoelastomers Synthesized via Thiol-Yne Michael Addition.

Journal Article Biomacromolecules · March 2022 Biodegradable shape memory elastomers have the potential for use in soft tissue engineering, drug delivery, and device fabrication applications. Unfortunately, few materials are able to meet the targeted degradation and mechanical properties needed for lon ... Full text Cite

Arene-perfluoroarene interactions confer enhanced mechanical properties to synthetic nanotubes

Journal Article Chemical Science · February 28, 2022 Supramolecular nanotubes prepared through macrocycle assembly offer unique properties that stem from their long-range order, structural predictability, and tunable microenvironments. However, assemblies that rely on weak non-covalent interactions often hav ... Full text Cite

Sugar-Based Polymers with Stereochemistry-Dependent Degradability and Mechanical Properties.

Journal Article Journal of the American Chemical Society · January 2022 Stereochemistry in polymers can be used as an effective tool to control the mechanical and physical properties of the resulting materials. Typically, though, in synthetic polymers, differences among polymer stereoisomers leads to incremental property varia ... Full text Cite

Stereochemistry-Controlled Mechanical Properties and Degradation in 3D-Printable Photosets.

Journal Article Journal of the American Chemical Society · October 2021 Stereochemistry provides an appealing handle by which to control the properties of small molecules and polymers. While it is established that stereochemistry in linear polymers affects their bulk mechanical properties, the application of this concept to ph ... Full text Cite

Poly(ethylene glycol) Hydrogel Crosslinking Chemistries Identified via Atmospheric Solids Analysis Probe Mass Spectrometry

Journal Article Macromolecules · September 14, 2021 Hydrogels are hydrophilic, crosslinked polymer networks that can absorb several times their own mass in water; they are frequently used in biomedical applications as a native tissue mimic. The characterization of hydrogels and other covalently crosslinked ... Full text Cite

Fabrication of Biomedical Scaffolds Using Biodegradable Polymers.

Journal Article Chemical reviews · September 2021 Degradable polymers are used widely in tissue engineering and regenerative medicine. Maturing capabilities in additive manufacturing coupled with advances in orthogonal chemical functionalization methodologies have enabled a rapid evolution of defect-speci ... Full text Cite

Introduction: Polymeric Biomaterials.

Journal Article Chemical reviews · September 2021 Full text Cite

Zooming in on polymer chemistry and designing synthesis of high sulfur-content polymers for virtual undergraduate laboratory experiment

Journal Article Journal of Chemical Education · June 8, 2021 Polymer chemistry is essential within chemical education because of its applications in academic and industrial research, materials science, and across engineering disciplines. Teaching polymer chemistry principles early on in the undergraduate curriculum ... Full text Cite

Crosslinked Internal Alkyne-Based Stereo Elastomers: Polymers with Tunable Mechanical Properties

Journal Article Macromolecules · May 25, 2021 New methods to introduce and control polymer network crosslinking and improve mechanical properties of the resulting materials have been investigated extensively. Common methods to enhance the mechanical properties of elastomers include "vulcanization"by w ... Full text Cite

Clustering and Hierarchical Organization of 3D Printed Poly(propylene fumarate)- block-PEG- block-poly(propylene fumarate) ABA Triblock Copolymer Hydrogels

Journal Article Macromolecules · April 13, 2021 Hydrogels are deployed widely in all areas of regenerative medicine, including bioprinting. The transport and mechanical properties exhibited by hydrogel assemblies are controlled by their organization and hierarchical assembly. This paper points out the r ... Full text Cite

Degradable polymeric vehicles for postoperative pain management.

Journal Article Nat Commun · March 1, 2021 Effective control of pain management has the potential to significantly decrease the need for prescription opioids following a surgical procedure. While extended release products for pain management are available commercially, the implementation of a devic ... Full text Link to item Cite

Regio-Random Clemmensen Reduction of Biodegradable Polyesters for Photochemically Triggered 3D Printing

Journal Article Macromolecules · February 9, 2021 A zinc/acetic acid-mediated Clemmensen reduction coupled with sonication affords a time-dependent regio-random reduction of degradable poly(propylene maleate) oligomers to poly(propylene fumarate-co-propylene succinate) co-polymers. Characterization by 1H ... Full text Cite

Polymeric Materials for Eye Surface and Intraocular Applications.

Journal Article Biomacromolecules · February 2021 Ocular applications of polymeric materials have been widely investigated for medical diagnostics, treatment, and vision improvement. The human eye is a vital organ that connects us to the outside world so when the eye is injured, infected, or impaired, it ... Full text Cite

Controlled release of etoricoxib from poly(ester urea) films for post-operative pain management.

Journal Article Journal of controlled release : official journal of the Controlled Release Society · January 2021 Medical prescriptions for the alleviation of post-surgical pain are the most abundant source of opioids in circulation. As a systemic drug delivery source, opioids leave patients at high risk for side effects after being dosed. Given the significant rate o ... Full text Cite

Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering.

Journal Article Nature communications · January 2021 Complex biological tissues are highly viscoelastic and dynamic. Efforts to repair or replace cartilage, tendon, muscle, and vasculature using materials that facilitate repair and regeneration have been ongoing for decades. However, materials that possess t ... Full text Cite

Underexplored Stereocomplex Polymeric Scaffolds with Improved Thermal and Mechanical Properties

Journal Article Macromolecules · December 8, 2020 Stereocomplexation has been shown to enhance the thermal and mechanical properties of polymers. The scope and utility of stereocomplexation have focused primarily on toughening of poly(l-lactic acid) (PLLA). Recently, additional polyester and polycarbonate ... Full text Cite

Degradation of Block Copolymer Films Confined in Elastic Media: Molecular Dynamics Simulations

Journal Article Macromolecules · November 10, 2020 Featured Publication We performed coarse-grained molecular dynamics simulations of swelling and degradation of copolymer films confined within polymer networks with different values of shear modulus. The microphase separated copolymer films are shown to degrade by surface and ... Full text Cite

Advancing Toward 3D Printing of Bioresorbable Shape Memory Polymer Stents.

Journal Article Biomacromolecules · October 2020 Featured Publication Stents have evolved significantly since their introduction to the medical field in the early 1980s, becoming widely used in percutaneous coronary interventions and following nephrological procedures. However, the current commercially available stents do no ... Full text Cite

Antibiotic eluting poly(ester urea) films for control of a model cardiac implantable electronic device infection.

Journal Article Acta Biomater · July 15, 2020 Cardiac implantable electronic device (CIED) infections acquired during or after surgical procedures are a major complication that are challenging to treat therapeutically, resulting in chronic and sometimes fatal infections. Localized delivery of antibiot ... Full text Link to item Cite

Zwitterion Surface-Functionalized Thermoplastic Polyurethane for Antifouling Catheter Applications.

Journal Article Biomacromolecules · July 2020 Featured Publication Immobilizing zwitterionic molecules on material surfaces has been a promising strategy for creating antifouling surfaces. Herein, we show the ability to surface derivatize an allyl-ether-functionalized thermoplastic polyurethane (TPU) with a zwitterionic t ... Full text Cite

Elastomeric polyamide biomaterials with stereochemically tuneable mechanical properties and shape memory.

Journal Article Nature communications · June 2020 Featured Publication Biocompatible polymers are widely used in tissue engineering and biomedical device applications. However, few biomaterials are suitable for use as long-term implants and these examples usually possess limited property scope, can be difficult to process, an ... Full text Cite

Alternating ring-opening copolymerization of epoxides with saturated and unsaturated cyclic anhydrides: Reduced viscosity poly(propylene fumarate) oligomers for use in cDLP 3D printing

Journal Article Polymer Chemistry · May 21, 2020 Featured Publication A ring-opening copolymerization of propylene oxide with saturated and unsaturated anhydrides using Mg(BHT)2(THF)2 catalyst followed by an isomerization yields poly(propylene fumarate) (PPF) oligomers with well-defined molecular mass, narrow molecular mass ... Full text Cite

4D Printing of Resorbable Complex Shape-Memory Poly(propylene fumarate) Star Scaffolds.

Journal Article ACS applied materials & interfaces · May 2020 3D/4D printing is enabling transformative advances in device manufacturing and medicine but remains limited by the lack of printable resorbable materials with advanced properties and functions. Herein, we report the rapid and precise 4D printing of shape-m ... Full text Cite

Solution-Processed Flexible Broadband Photodetectors with Solution-Processed Transparent Polymeric Electrode

Journal Article Advanced Functional Materials · April 1, 2020 Featured Publication Room-temperature solution-processed flexible photodetectors with spectral response from 300 to 2600 nm are reported. Solution-processed polymeric thin film with transparency ranging from 300 to 7000 nm and superior electrical conductivity as the transparen ... Full text Cite

Degradation of Films of Block Copolymers: Molecular Dynamics Simulations

Journal Article Macromolecules · February 25, 2020 Featured Publication Coarse-grained molecular dynamics simulations are used to study the degradation of films of copolymers in a selective solvent for one of the blocks. Simulations were designed to mimic the hydrolytic degradation of glycine, valine, and phenylalanine-based p ... Full text Cite

Continuous Fabrication of Antimicrobial Nanofiber Mats Using Post-Electrospinning Functionalization for Roll-to-Roll Scale-Up

Journal Article ACS Applied Polymer Materials · February 14, 2020 The facile fabrication of antimicrobial fiber mats with surface-attached quaternary ammonium compounds (QACs) as the contact-killing antimicrobials was demonstrated. The entire process was designed to be scaled up to a continuous roll-to-roll (R2R) process ... Full text Cite

Amino Acid-Based Poly(ester urea)s as a Matrix for Extended Release of Entecavir.

Journal Article Biomacromolecules · February 2020 Featured Publication The use of polymers as excipients for drug delivery has afforded stable formulations that reliably control the release of active pharmaceutical ingredients (APIs). While many materials are available and used, few polymers exhibit the numerous advantages, i ... Full text Cite

Unsaturated Poly(ester-urethanes) with Stereochemically Dependent Thermomechanical Properties

Journal Article Macromolecules · January 14, 2020 Polymer crystallinity is known to be dependent upon backbone stereochemistry, and this concept has emerged as an effective means of altering bulk material properties. Herein we describe a simple, step-growth polymerization to synthesize unsaturated poly(es ... Full text Cite

High performance perovskites solar cells by hybrid perovskites co-crystallized with poly(ethylene oxide)

Journal Article Nano Energy · January 1, 2020 Hybrid perovskite materials have emerged as attractive alternatives for cost-effective solar cells in the past ten years. However, achieving hysteresis-free, stable and efficient solution-processed perovskites solar cells has remained as a significant fund ... Full text Cite

Polymers: Basic Principles

Chapter · January 1, 2020 Polymers represent the largest class of materials used in medicine. They have a range of unique properties making them useful in biomaterial applications, including orthopedics, dental, hard and soft tissue replacements, drug delivery, and cardiovascular d ... Full text Cite

Modulating Bioglass Concentration in 3D Printed Poly(propylene fumarate) Scaffolds for Post-Printing Functionalization with Bioactive Functional Groups.

Journal Article Biomacromolecules · December 2019 Featured Publication Poly(propylene fumarate) (PPF) has shown potential for the treatment of bone defects as it can be 3D printed into scaffolds to suit patient-specific needs with strength comparable to that of bone. However, the lack of specific cell attachment and osteogeni ... Full text Cite

Postfabrication Tethering of Molecular Gradients on Aligned Nanofibers of Functional Poly(ε-caprolactone)s.

Journal Article Biomacromolecules · December 2019 Substrates with combinations of topographical and biochemical cues are highly useful for a number of fundamental biological investigations. Tethered molecular concentration gradients in particular are highly desired for a number of biomedical applications ... Full text Cite

Zwitterionic amino acid-based Poly(ester urea)s suppress adhesion formation in a rat intra-abdominal cecal abrasion model.

Journal Article Biomaterials · November 2019 Hernia repair outcomes have improved with more robust material options for surgeons and optimized surgical techniques. However, ventral hernia repairs remain challenging with an inherent risk of post-surgical adhesions in the peritoneal space which can occ ... Full text Cite

Cooperative Self‐Assembly of Pyridine‐2,6‐Diimine‐Linked Macrocycles into Mechanically Robust Nanotubes

Journal Article Angewandte Chemie · October 7, 2019 AbstractNanotubes assembled from macrocyclic precursors offer a unique combination of low dimensionality, structural rigidity, and distinct interior and exterior microenvironments. Usually the weak stacking energies of macr ... Full text Cite

Enhancing Schwann cell migration using concentration gradients of laminin-derived peptides.

Journal Article Biomaterials · October 2019 Neuroregeneration following peripheral nerve injury is largely mediated by Schwann cells (SC), the principal glial cell that supports neurons in the peripheral nervous system. Axonal regeneration in vivo is limited by the extent of SC migration into the ga ... Full text Cite

Optimization of photocrosslinkable resin components and 3D printing process parameters.

Journal Article Acta biomaterialia · October 2019 Featured Publication The role of 3D printing in the biomedical field is growing. In this context, photocrosslink-based 3D printing procedures for resorbable polymers stand out. Despite much work, more studies are needed on photocuring stereochemistry, new resin additives, new ... Full text Cite

Cooperative Self-Assembly of Pyridine-2,6-Diimine-Linked Macrocycles into Mechanically Robust Nanotubes.

Journal Article Angewandte Chemie (International ed. in English) · October 2019 Nanotubes assembled from macrocyclic precursors offer a unique combination of low dimensionality, structural rigidity, and distinct interior and exterior microenvironments. Usually the weak stacking energies of macrocycles limit the length and mechanical s ... Full text Cite

Poly(propylene fumarate) stars, using architecture to reduce the viscosity of 3D printable resins

Journal Article Polymer Chemistry · September 14, 2019 Featured Publication Additive manufacturing is changing tissue engineering by offering pathways to otherwise unattainable, highly complex scaffold morphologies. Linear poly(propylene fumarate) (PPF) oligomers have demonstrated remarkable properties for 3D printing of porous gy ... Full text Cite

Molecular Mass-Dependent Resorption and Bone Regeneration of 3D Printed PPF Scaffolds in a Critical-Sized Rat Cranial Defect Model.

Journal Article Advanced healthcare materials · September 2019 The emergence of additive manufacturing has afforded the ability to fabricate intricate, high resolution, and patient-specific polymeric implants. However, the availability of biocompatible resins with tunable resorption profiles remains a significant hurd ... Full text Cite

Stereochemical enhancement of polymer properties

Journal Article Nature Reviews Chemistry · September 1, 2019 The importance of stereochemistry to the function of molecules is generally well understood. However, to date, control over stereochemistry and its potential to influence properties of the resulting polymers are, as yet, not fully realized. This Review foc ... Full text Cite

Tuning Cooperative Assembly with Bottlebrush Block Co-polymers for Porous Metal Oxide Films Using Solvent Mixtures.

Journal Article Langmuir : the ACS journal of surfaces and colloids · July 2019 Featured Publication Block copolymer templating enables the generation of well-defined pore sizes and geometries in a wide variety of frameworks, typically through evaporation-induced self-assembly (EISA). Here, we systematically modulate the solvent quality with mixtures of t ... Full text Cite

Poly(propylene fumarate)-based materials: Synthesis, functionalization, properties, device fabrication and biomedical applications.

Journal Article Biomaterials · July 2019 Featured Publication Poly(propylene fumarate) (PPF) is a biodegradable polymer that has been investigated extensively over the last three decades. It has led many scientists to synthesize and fabricate a variety of PPF-based materials for biomedical applications due to its con ... Full text Cite

3D Printing of Poly(propylene fumarate) Oligomers: Evaluation of Resin Viscosity, Printing Characteristics and Mechanical Properties.

Journal Article Biomacromolecules · April 2019 Featured Publication Complex three-dimensional (3D) pore geometries, useful for tissue engineering scaffolds, can be fabricated via photo-crosslinking of resorbable poly(propylene fumarate) (PPF) resins using stereolithography (SLA) and/or continuous digital light processing ( ... Full text Cite

RGD-Functionalized Nanofibers Increase Early GFAP Expression during Neural Differentiation of Mouse Embryonic Stem Cells.

Journal Article Biomacromolecules · March 2019 Featured Publication Stem cell differentiation toward a specific lineage is controlled by its microenvironment. Polymer scaffolds have long been investigated to provide microenvironment cues; however, synthetic polymers lack the specific signaling motifs necessary to direct ce ... Full text Cite

Mechanically tunable, human mesenchymal stem cell viable poly(ethylene glycol)–oxime hydrogels with invariant precursor composition, concentration, and stoichiometry

Journal Article Materials Today Chemistry · March 1, 2019 Featured Publication Hydrogels are used widely for exploratory tissue engineering studies. However, currently, no hydrogel systems have been reported which exhibit a wide range of elastic modulus without changing precursor concentration, identity, or stoichiometry. Herein, est ... Full text Cite

Morphological control of hydrothermally synthesized cobalt oxide particles using poly(vinyl pyrrolidone)

Journal Article Colloid and Polymer Science · January 17, 2019 Featured Publication The hydrothermal synthesis of Co 3 O 4 particles using cobalt nitrate as the precursor and citric acid as a weak chelating agent was modulated using poly(vinyl pyrrolidone) (PVP) to control the shape and size of the resulting particles. The molar ratio of ... Full text Cite

RGD-modified nanofibers enhance outcomes in rats after sciatic nerve injury

Journal Article Journal of Functional Biomaterials · January 1, 2019 Featured Publication Nerve injuries requiring surgery are a significant problem without good clinical alternatives to the autograft. Tissue engineering strategies are critically needed to provide an alternative. In this study, we utilized aligned nanofibers that were click-mod ... Full text Cite

Photopolymerizable Resins for 3D-Printing Solid-Cured Tissue Engineered Implants.

Journal Article Current drug targets · January 2019 Featured Publication With the advent of inexpensive and highly accurate 3D printing devices, a tremendous flurry of research activity has been unleashed into new resorbable, polymeric materials that can be printed using three approaches: hydrogels for bioprinting and bioplotti ... Full text Cite

Amino acid-based Poly(ester urea) copolymer films for hernia-repair applications.

Journal Article Biomaterials · November 2018 The use of degradable materials is required to address current performance and functionality shortcomings from biologically-derived tissues and non-resorbable synthetic materials used for hernia mesh repair applications. Herein a series of degradable l-val ... Full text Cite

Nonlinear Mechano-Optical Behavior and Strain-Induced Structural Changes of l -Valine-Based Poly(ester urea)s

Journal Article Macromolecules · October 23, 2018 The uniaxial mechano-optical behavior of a series of amorphous l-valine-based poly(ester urea) (VAL-PEU) with varying diol lengths was studied to elucidate the molecular mechanism associated with their thermal shape memory properties. A custom, real-time m ... Full text Cite

Synthesis and 3D Printing of PEG-Poly(propylene fumarate) Diblock and Triblock Copolymer Hydrogels

Journal Article ACS Macro Letters · October 16, 2018 PEG-based hydrogels are used widely in exploratory tissue engineering applications but in general lack chemical and structural diversity. Additive manufacturing offers pathways to otherwise unattainable scaffold morphologies but has been applied sparingly ... Full text Cite

Post-fabrication QAC-functionalized thermoplastic polyurethane for contact-killing catheter applications.

Journal Article Biomaterials · September 2018 The use of catheters is ubiquitous in medicine and the incidence of infection remains unacceptably high despite numerous advances in functional surfaces and drug elution. Herein we report the use of a thermoplastic polyurethane containing an allyl ether si ... Full text Cite

Ring-Opening Copolymerization of Maleic Anhydride with Functional Epoxides: Poly(propylene fumarate) Analogues Capable of Post-Polymerization Modification.

Journal Article Angewandte Chemie (International ed. in English) · September 2018 Three functional epoxides were copolymerized with maleic anhydride to yield degradable poly(propylene fumarate) analogues. The polymers were modified post-polymerization and post-printing with either click-type addition reactions or UV deprotection to eith ... Full text Cite

Versatile Ring-Opening Copolymerization and Postprinting Functionalization of Lactone and Poly(propylene fumarate) Block Copolymers: Resorbable Building Blocks for Additive Manufacturing

Journal Article Macromolecules · August 28, 2018 Additive manufacturing has the potential to change medicine, but clinical applications are limited by a lack of resorbable, printable materials. Herein, we report the first synthesis of polylactone and poly(propylene fumarate) (PPF) block copolymers with w ... Full text Cite

Polymers at the Interface with Biology.

Journal Article Biomacromolecules · August 2018 Full text Cite

pH-Responsive, Functionalizable Spyrocyclic Polycarbonate: A Versatile Platform for Biocompatible Nanoparticles.

Journal Article Biomacromolecules · August 2018 Polymeric nanoparticles are widely investigated to enhance the selectivity of therapeutics to targeted sites, as well as to increase circulation lifetime and water solubility of poorly soluble drugs. In contrast to the encapsulation of the cargo into the n ... Full text Cite

Accelerated neural differentiation of mouse embryonic stem cells on aligned GYIGSR-functionalized nanofibers.

Journal Article Acta biomaterialia · July 2018 Substrates for embryonic stem cell culture are typified by poorly defined xenogenic, whole proteins or cellular components that are difficult and expensive to generate, characterize, and recapitulate. Herein, the generation of well-defined scaffolds of Gly ... Full text Cite

Enhanced Rotator-Cuff Repair Using Platelet-Rich Plasma Adsorbed on Branched Poly(ester urea)s.

Journal Article Biomacromolecules · July 2018 Platelet-rich plasma (PRP) is a clinically relevant source of growth factors used commonly by surgeons. The clinical efficacy of PRP use as reported in the literature is widely variable which is likely attributed to poorly defined retention time of PRP at ... Full text Cite

Preclinical in Vitro and in Vivo Assessment of Linear and Branched l -Valine-Based Poly(ester urea)s for Soft Tissue Applications

Journal Article ACS Biomaterials Science and Engineering · April 9, 2018 New polymers are needed to address the shortcomings of commercially available materials for soft tissue repair. Herein, we investigated a series of l-valine-based poly(ester urea)s (PEUs) that vary in monomer composition and the extent of branching as cand ... Full text Cite

Neural stem cell encapsulation and differentiation in strain promoted crosslinked polyethylene glycol-based hydrogels.

Journal Article Journal of biomaterials applications · April 2018 Encapsulated cell viability within crosslinked hydrogels is a critical factor to consider in regenerative medicine/cell delivery applications. Herein, a "click" hydrogel system is presented encompassing 4-dibenzocyclooctynol functionalized polyethylene gly ... Full text Cite

Antimicrobial and Antifouling Strategies for Polymeric Medical Devices.

Journal Article ACS macro letters · January 2018 Hospital-acquired infections arising from implanted polymeric medical devices continue to pose a significant challenge for medical professionals and patients. Often times, these infections arise from biofilm accumulation on the device, which is difficult t ... Full text Cite

Magnesium Catalyzed Polymerization of End Functionalized Poly(propylene maleate) and Poly(propylene fumarate) for 3D Printing of Bioactive Scaffolds.

Journal Article Journal of the American Chemical Society · January 2018 The ring-opening copolymerization of maleic anhydride and propylene oxide, using a functionalized primary alcohol initiator and magnesium 2,6-di-tert-butyl phenoxide as a catalyst, was investigated in order to produce high end-group fidelity poly(propylene ... Full text Cite

Multidimensional mass spectrometry characterization of isomeric biodegradable polyesters.

Journal Article European journal of mass spectrometry (Chichester, England) · December 2017 The biodegradable polyester copolymer poly(propylene fumarate) (PPF) is increasingly utilized in bone tissue engineering studies due to its suitability as inert cross-linkable scaffold material. The well-defined poly(propylene fumarate) oligomers needed fo ... Full text Cite

Three-Dimensional Printing of Nano Hydroxyapatite/Poly(ester urea) Composite Scaffolds with Enhanced Bioactivity.

Journal Article Biomacromolecules · December 2017 Polymer-bioceramic composites incorporate the desirable properties of each material while mitigating the limiting characteristics of each component. 1,6-Hexanediol l-phenylalanine-based poly(ester urea) (PEU) blended with hydroxyapatite (HA) nanocrystals w ... Full text Cite

Biodegradable Shape Memory Polymers in Medicine.

Journal Article Advanced healthcare materials · November 2017 Shape memory materials have emerged as an important class of materials in medicine due to their ability to change shape in response to a specific stimulus, enabling the simplification of medical procedures, use of minimally invasive techniques, and access ... Full text Cite

Degradable Adhesives for Surgery and Tissue Engineering.

Journal Article Biomacromolecules · October 2017 This review highlights the research on degradable polymeric tissue adhesives for surgery and tissue engineering. Included are a comprehensive listing of specific uses, advantages, and disadvantages of different adhesive groups. A critical evaluation of cha ... Full text Cite

Modification of Poly(propylene fumarate)-Bioglass Composites with Peptide Conjugates to Enhance Bioactivity.

Journal Article Biomacromolecules · October 2017 Poly(propylene fumarate) (PPF) has been highlighted as one of the most promising materials for bone regeneration. Despite the promising advantages of using polymer scaffolds for biomedical applications, their inherent lack of bioactivity has limited their ... Full text Cite

Enhanced osteogenic activity of poly(ester urea) scaffolds using facile post-3D printing peptide functionalization strategies.

Journal Article Biomaterials · October 2017 Additive manufacturing has the potential to revolutionize regenerative medicine, but the harsh thermal or photochemical conditions during the 3D printing process limit the inclusion of drugs, growth factors and other biologics within the resulting scaffold ... Full text Cite

Sustained release of recombinant human growth hormone from bioresorbable poly(ester urea) nanofibers

Journal Article ACS Macro Letters · August 15, 2017 Recombinant human growth hormone (rhGH) has been used clinically for several decades. However, rhGH has a short half-life in vivo and therefore for efficacy requires frequent subcutaneous injection, leading to pain and poor patient compliance. An effective ... Full text Cite

Tunable Shape Memory Polymers from α-Amino Acid-Based Poly(ester urea)s

Journal Article Macromolecules · June 13, 2017 The thermal shape memory behavior of poly(ester urea)s (PEUs) composed of varying α-amino acids and linear diols has been explored. The thermal, mechanical, and shape memory properties of PEUs are shown to be controlled by changing the amino acid and diol ... Full text Cite

Design and mechanical characterization of solid and highly porous 3D printed poly(propylene fumarate) scaffolds

Journal Article Progress in Additive Manufacturing · June 1, 2017 The primary goal of tissue engineering is to repair a defect by encouraging new tissue growth and remodeling of that tissue within a biodegradable scaffold. The scaffold is the centerpiece of tissue engineering efforts, and its design and properties are of ... Full text Cite

Effect of Chemical and Physical Properties on the In Vitro Degradation of 3D Printed High Resolution Poly(propylene fumarate) Scaffolds.

Journal Article Biomacromolecules · April 2017 Two distinct molecular masses of poly(propylene fumarate) (PPF) are combined with an additive manufacturing process to fabricate highly complex scaffolds possessing controlled chemical properties and porous architecture. Scaffolds were manufactured with tw ... Full text Cite

Role of Hydrogen Bonding on Nonlinear Mechano-Optical Behavior of l-Phenylalanine-Based Poly(ester urea)s

Journal Article Macromolecules · February 14, 2017 The uniaxial mechano-optical behavior of a series of amorphous l-phenylalanine-based poly(ester urea) (PEU) films was studied in the rubbery state. A custom, real-time measurement system was used to capture the true stress, true strain, and birefringence d ... Full text Cite

High-content image informatics of the structural nuclear protein NuMA parses trajectories for stem/progenitor cell lineages and oncogenic transformation.

Journal Article Experimental cell research · February 2017 Stem and progenitor cells that exhibit significant regenerative potential and critical roles in cancer initiation and progression remain difficult to characterize. Cell fates are determined by reciprocal signaling between the cell microenvironment and the ... Full text Cite

Mass Spectrometry and Ion Mobility Characterization of Bioactive Peptide-Synthetic Polymer Conjugates.

Journal Article Analytical chemistry · January 2017 The bioconjugate BMP2-(PEO-HA)2, composed of a dendron with two monodisperse poly(ethylene oxide) (PEO) branches terminated by a hydroxyapatite binding peptide (HA), and a focal point substituted with a bone growth stimulating peptide (BMP2), ha ... Full text Cite

Solid state microwave synthesis of highly crystalline ordered mesoporous hausmannite Mn3O4 films

Journal Article CrystEngComm · January 1, 2017 Soft templating using block copolymers provides a generalized synthetic strategy to fabricate mesoporous materials, but it is generally challenging to obtain highly crystalline frameworks without significant deformation or loss of the mesoporous structure. ... Full text Cite

Optical High Content Nanoscopy of Epigenetic Marks Decodes Phenotypic Divergence in Stem Cells.

Journal Article Scientific reports · January 2017 While distinct stem cell phenotypes follow global changes in chromatin marks, single-cell chromatin technologies are unable to resolve or predict stem cell fates. We propose the first such use of optical high content nanoscopy of histone epigenetic marks ( ... Full text Cite

Poly(ester urea)-Based Adhesives: Improved Deployment and Adhesion by Incorporation of Poly(propylene glycol) Segments

Journal Article ACS Applied Materials and Interfaces · December 14, 2016 The adhesive nature of mussels arises from the catechol moiety in the 3,4-dihydroxyphenylalanine (DOPA) amino acid, one of the many proteins that contribute to the unique adhesion properties of mussels. Inspired by these properties, many biomimetic adhesiv ... Full text Cite

α-Amino Acid-Based Poly(Ester urea)s as Multishape Memory Polymers for Biomedical Applications

Journal Article ACS Macro Letters · October 18, 2016 The thermal shape memory behavior of a series of α-amino acid-based poly(ester urea)s has been explored. We demonstrate that these materials exhibit excellent shape memory performance in dual- and triple-shape thermomechanical testing. Significant activati ... Full text Cite

Independent Control of Elastomer Properties through Stereocontrolled Synthesis

Journal Article Angewandte Chemie - International Edition · October 10, 2016 In most synthetic elastomers, changing the physical properties by monomer choice also results in a change to the crystallinity of the material, which manifests through alteration of its mechanical performance. Using organocatalyzed stereospecific additions ... Full text Cite

Adhesion of Blood Plasma Proteins and Platelet-rich Plasma on l-Valine-Based Poly(ester urea).

Journal Article Biomacromolecules · October 2016 The competitive absorption of blood plasma components including fibrinogen (FG), bovine serum albumin (BSA), and platelet-rich plasma (PRP) on l-valine-based poly(ester urea) (PEU) surfaces were investigated. Using four different PEU polymers, possessing c ... Full text Cite

Influence of Sterilization Technologies on Electrospun Poly(ester urea)s for Soft Tissue Repair.

Journal Article Biomacromolecules · October 2016 Degradable poly(ester urea)s (PEU)s were electrospun into nanofiber sheets and assessed for their potential to be used in soft tissue repair. The level of residual solvent was measured and the effects of ethylene oxide and electron beam sterilization techn ... Full text Cite

Caddisfly Inspired Phosphorylated Poly(ester urea)-Based Degradable Bone Adhesives.

Journal Article Biomacromolecules · September 2016 Bone and tissue adhesives are essential in surgeries for wound healing, hemostasis, tissue reconstruction, and drug delivery. However, there are very few degradable materials with high adhesion strengths that degrade into bioresorbable byproducts. Caddisfl ... Full text Cite

Pilot Mouse Study of 1 mm Inner Diameter (ID) Vascular Graft Using Electrospun Poly(ester urea) Nanofibers.

Journal Article Advanced healthcare materials · September 2016 An off-the-shelf, small diameter tissue engineered vascular graft (TEVG) would be transformative to surgeons in multiple subspecialties. Herein, the results of a small diameter (ID ≈ 1 mm) vascular graft constructed from resorbable, amino acid-based poly(e ... Full text Cite

Evolution in surface morphology during rapid microwave annealing of PS-b-PMMA thin films

Journal Article Journal of Polymer Science, Part B: Polymer Physics · August 1, 2016 Microwave annealing enables rapid (60 s) ordering and orientation of block copolymer films. The developed morphology in polystyrene-block-poly(methyl methacrylate) (PS-b-PMMA) thin films depends on details of the heating rate that is controlled by microwav ... Full text Cite

Synthesis of polyisobutylene-polycaprolactone block copolymers using enzyme catalysis

Journal Article Express Polymer Letters · August 1, 2016 The synthesis of poly(isobutylene-b-ε-caprolactone) diblock and poly(ε-caprolactone-b-isobutylene-b-ε-caprolactone) triblock copolymers was accomplished using a combination of living carbocationic polymerization of isobutylene (IB) with the ring-opening po ... Full text Cite

Multiscale approach for the construction of equilibrated all-atom models of a poly(ethylene glycol)-based hydrogel.

Journal Article Biointerphases · June 2016 A multiscale modeling approach is presented for the efficient construction of an equilibrated all-atom model of a cross-linked poly(ethylene glycol) (PEG)-based hydrogel using the all-atom polymer consistent force field (PCFF). The final equilibrated all-a ... Full text Cite

Osteogenic growth peptide and its use as a bio-conjugate in regenerative medicine applications.

Journal Article Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · May 2016 For nearly 2000 years, biomaterials have been used as damaged tissue implants. A field that started with wood and gold tissue replacements has evolved into an advanced science which combines ideas of cellular biology, engineering, and synthetic chemistry t ... Full text Cite

Concentration-Dependent hMSC Differentiation on Orthogonal Concentration Gradients of GRGDS and BMP-2 Peptides.

Journal Article Biomacromolecules · April 2016 Self-assembled monolayer substrates containing tethered orthogonal concentration profiles of GRGDS (glycine/arginine/glycine/aspartic acid/serine) and BMP-2 (bone morphogenetic protein) peptides are shown to accelerate or decelerate, depending on the conce ... Full text Cite

Ionomers for Tunable Softening of Thermoplastic Polyurethane

Journal Article Macromolecules · February 9, 2016 Thermoplastic polyurethane (TPU) sulfonate ionomers with quaternary ammonium cations were synthesized to achieve soft TPUs without using conventional low molecular weight plasticizers. The sulfonated monomer N,N-bis(2-hydroxyethyl)-2-aminoethanesulfonic ac ... Full text Cite

Synthesis and Biological Evaluation of Well-Defined Poly(propylene fumarate) Oligomers and Their Use in 3D Printed Scaffolds.

Journal Article Biomacromolecules · February 2016 A ring opening polymerization method for synthesizing oligomeric poly(propylene fumarate) (PPF) provides a rapid, and scalable method of synthesizing PPF with well-defined molecular mass, molecular mass distribution (Đm), and viscosity properties suitable ... Full text Cite

Control of Mesh Size and Modulus by Kinetically Dependent Cross-Linking in Hydrogels.

Journal Article Advanced materials (Deerfield Beach, Fla.) · October 2015 Kinetically controlled cross-linking processes produce mechanically distinguishable hydrogels using identical precursor chemistry. The oxime ligation demonstrates tunable reaction kinetics with pH and buffer strength, which induce changes in the structural ... Full text Cite

L -Leucine-Based Poly(ester urea)s for Vascular Tissue Engineering

Journal Article ACS Biomaterials Science and Engineering · September 14, 2015 Poly(ester urea)s (PEUs) derived from α-amino acids are promising for vascular tissue engineering applications. The objective of this work was to synthesize and characterize l-leucine-based PEUs and evaluate their suitability for vascular tissue engineerin ... Full text Cite

Three-Dimensional Bicontinuous Graphene Monolith from Polymer Templates

Journal Article ACS Nano · June 23, 2015 The two-dimensional single-layer and few-layered graphene exhibit many attractive properties such as large specific surface area and high charge carrier mobility. However, graphene sheets tend to stack together and form aggregates, which do not possess the ... Full text Cite

Branched amino acid based poly(ester urea)s with tunable thermal and water uptake properties

Journal Article Macromolecules · May 12, 2015 A series of amino-acid based poly(ester urea)s (PEU) with controlled amounts of branching was synthesized and characterized. The mechanical properties, thermal characteristics and water absorptions varied widely with the extent of branch unit incorporation ... Full text Cite

Thermoresponsive dual emission nanosensor based on quantum dots and dye labeled poly(N-isopropylacrylamide)

Journal Article Polymer Chemistry · April 21, 2015 Dual end-functionalized telechelic poly(N-isopropylacrylamide) (PNIPAM) was synthesized using reversible addition-fragmentation chain-transfer (RAFT) polymerization. One end was coupled to a fluorescent dye and the other end was covalently coupled to CdSe/ ... Full text Cite

OGP functionalized phenylalanine-based poly(ester urea) for enhancing osteoinductive potential of human mesenchymal stem cells.

Journal Article Biomacromolecules · April 2015 Amino acid-based poly(ester urea)s (PEU) are high modulus, resorbable polymers with many potential uses, including the surgical repair of bone defects. In vitro and in vivo studies have previously shown that phenylalanine-based PEUs have nontoxic hydrolyti ... Full text Cite

Rapid (<3 min) microwave synthesis of block copolymer templated ordered mesoporous metal oxide and carbonate films using nitrate-citric acid systems.

Journal Article Chemical communications (Cambridge, England) · March 2015 Rapid chemical transformation from micelle templated precursors (metal nitrate and citric acid) to ordered mesoporous metal carbonates and oxides is demonstrated using microwave heating for cobalt, copper, manganese and zinc. Without aging requirements, <3 ... Full text Cite

Consequences of water between two hydrophobic surfaces on adhesion and wetting.

Journal Article Langmuir : the ACS journal of surfaces and colloids · March 2015 The contact of two hydrophobic surfaces in water is of importance in biology, catalysis, material science, and geology. A tenet of hydrophobic attraction is the release of an ordered water layer, leading to a dry contact between two hydrophobic surfaces. A ... Full text Cite

Green polymer chemistry: Synthesis of symmetric and asymmetric telechelic ethylene glycol oligomers

Journal Article Polymer Chemistry · February 21, 2015 In this work we investigated the kinetics of the transesterification of divinyl adipate (DVA) with tetraethylene glycol (TEG) using Candida antarctica lipase B (CALB) as a biocatalyst at 50 °C under solventless conditions. We examined the time-dependence o ... Full text Cite

Post-electrospinning "triclick" functionalization of degradable polymer nanofibers

Journal Article ACS Macro Letters · February 17, 2015 4-Dibenzocyclooctynol (DIBO) was used as an initiator for the ring-opening copolymerization of ε-caprolactone and 1,4,8-trioxaspiro[4.6]-9-undecanone (TOSUO) resulting in a series of DIBO end-functionalized copolymers. Following deprotection of the ketone ... Full text Cite

3D printing of resorbable poly(propylene fumarate) tissue engineering scaffolds

Journal Article MRS Bulletin · February 12, 2015 Efficient, reproducible, and precise methodologies for fabricating tissue engineering (TE) scaffolds using three-dimensional (3D) printing techniques are evaluated. Fusion deposition modeling, laser sintering, and photo printing each have limitations, incl ... Full text Cite

Radiopaque, iodine functionalized, phenylalanine-based poly(ester urea)s.

Journal Article Biomacromolecules · February 2015 The synthesis and characterization of iodine-functionalized phenylalanine-based poly(ester urea)s (PEUs) are reported. 4-Iodo-L-phenylalanine and L-phenylalanine were separately reacted with 1,6-hexanediol to produce two monomers, bis-4-I-L-phenylalanine-1 ... Full text Cite

Enhanced Schwann cell attachment and alignment using one-pot "dual click" GRGDS and YIGSR derivatized nanofibers.

Journal Article Biomacromolecules · January 2015 Using metal-free click chemistry and oxime condensation methodologies, GRGDS and YIGSR peptides were coupled to random and aligned degradable nanofiber networks postelectrospinning in a one-pot reaction. The bound peptides are bioactive, as demonstrated by ... Full text Cite

Adhesion properties of catechol-based biodegradable amino acid-based poly(ester urea) copolymers inspired from mussel proteins.

Journal Article Biomacromolecules · January 2015 Amino acid-based poly(ester urea) (PEU) copolymers functionalized with pendant catechol groups that address the need for strongly adhesive yet degradable biomaterials have been developed. Lap-shear tests with aluminum adherends demonstrated that these poly ... Full text Cite

Bioactive surface modification of metal oxides via catechol-bearing modular peptides: multivalent-binding, surface retention, and peptide bioactivity.

Journal Article Journal of the American Chemical Society · November 2014 A series of multivalent dendrons containing a bioactive osteogenic growth peptide (OGP) domain and surface-binding catechol domains were obtained through solid phase synthesis, and their binding affinity to hydroxyapatite, TiO2, ZrO2, CeO2, Fe3O4 and gold ... Full text Cite

Dopamine-based copper-free click kit for efficient surface functionalization

Journal Article ACS Macro Letters · October 21, 2014 (Chemical Equation Presented). Strain-promoted azide-alkyne cycloaddition reactions are combined with a dopamine functional species to generate a highly efficient method for surface modification. The resulting conjugate containing 4-dibenzocyclooctynol (DI ... Full text Cite

New method for the synthesis of fully aliphatic telechelic α,ω-dihydroxy-polyisobutylene

Journal Article Polymer Chemistry · September 21, 2014 This paper reports a new method for the synthesis of α,ω- primary-dihydroxy PIBs (HO-PIB-OH) with a fully aliphatic backbone. Three aliphatic difunctional initiators with tertiary-methoxy, tertiary-chloride and tertiary-hydroxyl end groups (TMHDiOMe, TMHDi ... Full text Cite

Enzyme-catalyzed ring-opening polymerization of ε-caprolactone using alkyne functionalized initiators

Journal Article Polymer Chemistry · March 21, 2014 Well-defined poly(caprolactone)s were generated using alkyne-based initiating systems catalyzed by Candida antarctica Lipase B (CALB). Propargyl alcohol and 4-dibenzocyclooctynol (DIBO) were shown to efficiently initiate the polymerizations under metal fre ... Full text Cite

Phenylalanine-based poly(ester urea): Synthesis, characterization, and in vitro degradation

Journal Article Macromolecules · January 14, 2014 A new class of l-phenylalanine-based poly(ester urea)s (PEU) was developed that possess tunable mechanical properties and degradation rates. Our preliminary data have shown that 1,6-hexanediol-l-phenylalanine-based poly(ester urea)s possess an elastic modu ... Full text Cite

"Click" reactions: a versatile toolbox for the synthesis of peptide-conjugates.

Journal Article Chemical Society reviews · January 2014 Peptides that comprise the functional subunits of proteins have been conjugated to versatile materials (biomolecules, polymers, surfaces and nanoparticles) in an effort to modulate cell responses, specific binding affinity and/or self-assembly behavior. Ho ... Full text Cite

Enzyme-catalyzed quantitative chain-end functionalization of poly(ethylene glycol)s under solventless conditions

Journal Article RSC Advances · January 1, 2014 This is the first report of quantitative vinyl chain-end functionalization of poly(ethylene glycol)s (PEGs) with reduced environmental effects and renewable catalysis. Divinyl adipate (DVA) was transesterified using Candida antarctica lipase B (CALB) suppo ... Full text Cite

Postelectrospinning "click" modification of degradable amino acid-based poly(ester urea) nanofibers

Journal Article Macromolecules · December 23, 2013 Amino acid-based poly(ester urea)s (PEU) are emerging as a new class of degradable polymers that have shown promise in regenerative medicine applications. Herein, we report the synthesis of PEUs carrying pendent "clickable" groups on modified tyrosine amin ... Full text Cite

Water-soluble CdTe quantum dots as an anode interlayer for solution-processed near infrared polymer photodetectors

Journal Article Nanoscale · December 2, 2013 Water-soluble cadmium telluride (CdTe) quantum dots (QDs) used as an anode interlayer in solution-processed near infrared (NIR) polymer photodetectors (PDs) were demonstrated. Polymer PDs incorporated with CdTe QDs as an anode interlayer exhibited 10-fold ... Full text Cite

Directed differentiation and neurite extension of mouse embryonic stem cell on aligned poly(lactide) nanofibers functionalized with YIGSR peptide.

Journal Article Biomaterials · December 2013 End-functional PLLA nanofibers were fabricated into mats of random or aligned fibers and functionalized post-spinning using metal-free "click chemistry" with the peptide Tyr-Ile-Gly-Ser-Arg (YIGSR). Fibers that were both aligned and functionalized with YIG ... Full text Cite

Cascading one-pot synthesis of single-tailed and asymmetric multitailed giant surfactants

Journal Article ACS Macro Letters · November 19, 2013 Rapid and precise synthesis of macromolecules has been a grand challenge in polymer chemistry. In this letter, we describe a convenient, rapid, and robust strategy for a one-pot synthesis of various precisely defined giant surfactants based on polyhedral o ... Full text Cite

Peptide-functionalized oxime hydrogels with tunable mechanical properties and gelation behavior.

Journal Article Biomacromolecules · October 2013 We demonstrate the formation of polyethylene glycol (PEG) based hydrogels via oxime ligation and the photoinitiated thiol-ene 3D patterning of peptides within the hydrogel matrix postgelation. The gelation process and final mechanical strength of the hydro ... Full text Cite

Influence of discrete and continuous culture conditions on human mesenchymal stem cell lineage choice in RGD concentration gradient hydrogels.

Journal Article Biomacromolecules · September 2013 Stem cells have shown lineage-specific differentiation when cultured on substrates possessing signaling groups derived from the native tissue. A distinct determinant in this process is the concentration of the signaling motif. While several groups have bee ... Full text Cite

Valency-dependent affinity of bioactive hydroxyapatite-binding dendrons.

Journal Article Biomacromolecules · September 2013 Hydroxyapatite (HA)-coated surfaces are used widely as stationary phase for protein and enzyme purification, coatings for dental and orthopedic implants, and composite materials for tissue engineering substrates. More advanced applications are envisioned, ... Full text Cite

Green polymer chemistry VIII: synthesis of halo-ester-functionalized poly(ethylene glycol)s via enzymatic catalysis.

Journal Article Macromolecular rapid communications · September 2013 Halo-ester-functionalized poly(ethylene glycol)s (PEGs) are successfully prepared by the transesterification of alkyl halo-esters with PEGs using Candida antarctica lipase B (CALB) as a biocatalyst under the solventless conditions. Transesterifications of ... Full text Cite

Sequential triple "click" approach toward polyhedral oligomeric silsesquioxane-based multiheaded and multitailed giant surfactants

Journal Article ACS Macro Letters · August 20, 2013 This letter reports a sequential triple "click" chemistry method for the precise synthesis of functional polyhedral oligomeric silsesquioxane (POSS)-based multiheaded and multitailed giant surfactants. A vinyl POSS-based heterobifunctional building block p ... Full text Cite

Cascading "Triclick" functionalization of poly(caprolactone) thin films quantified via a quartz crystal microbalance.

Journal Article Biomacromolecules · August 2013 A series of mono- and multifunctionalized degradable polyesters bearing various "clickable" groups, including ketone, alkyne, azide, and methyl acrylate (MA) are reported. Using this approach, we demonstrate a cascade approach to immobilize and quantitate ... Full text Cite

Maximizing phenotype constraint and extracellular matrix production in primary human chondrocytes using arginine-glycine-aspartate concentration gradient hydrogels.

Journal Article Acta biomaterialia · July 2013 New systematic approaches are necessary to determine and optimize the chemical and mechanical scaffold properties for hyaline cartilage generation using the limited cell numbers obtained from primary human sources. Peptide functionalized hydrogels possessi ... Full text Cite

Capillary wave confinement-induced stabilization of polymer films

Journal Article ACS Applied Materials and Interfaces · May 22, 2013 We show that temporary confinement of polystyrene thin films by an elastomeric capping layer possessing nanoimprinted subcapillary wavelength (λ ≪ λcap (20 μm)) line channels (amplitude A ≈ 120 nm) can suppress film dewetting on thermodynamically unfavorab ... Full text Cite

Tuning energy levels of low bandgap semi-random two acceptor copolymers

Journal Article Macromolecules · May 14, 2013 A series of low bandgap semi-random copolymers incorporating various ratios of two acceptor units - thienothiadiazole and benzothiadiazole - were synthesized by Pd-catalyzed Stille coupling. The polymer films exhibited broad and intense absorption spectra, ... Full text Cite

Concentration dependent neural differentiation and neurite extension of mouse ESC on primary amine-derivatized surfaces

Journal Article Biomaterials Science · May 1, 2013 Cell sourcing continues to be a significant limitation to regenerative medicine especially in neural lineages where population heterogeneity during in vitro culture prevents definitive phenotype assessment. For nearly 40 years, the biological community has ... Full text Cite

4-Dibenzocyclooctynol (DIBO) as an initiator for poly(ε-caprolactone): Copper-free clickable polymer and nanofiber-based scaffolds

Journal Article Polymer Chemistry · April 7, 2013 Utilization of 4-dibenzocyclooctynol (DIBO) as an initiator for the ring-opening polymerization of ε-caprolactone yields well-defined, high molecular weight poly(ε-caprolactone) end functionalized with DIBO (DIBO-PCL). Nanofibers bearing reactive DIBO grou ... Full text Cite

Primary human chondrocyte extracellular matrix formation and phenotype maintenance using RGD-derivatized PEGDM hydrogels possessing a continuous Young's modulus gradient.

Journal Article Acta biomaterialia · April 2013 Efficient ex vivo methods for expanding primary human chondrocytes while maintaining the phenotype is critical to advancing the sourcing of autologous cells for tissue engineering applications. While there has been significant research reported in the lite ... Full text Cite

Facile fabrication of "dual click" one- and two-dimensional orthogonal peptide concentration gradients.

Journal Article Biomacromolecules · March 2013 Peptides, proteins, and extracellular matrix act synergistically to influence cellular function at the biotic-synthetic interface. However, identifying the individual and cooperative contributions of the various combinations and concentration regimes is ex ... Full text Cite

Resorbable, amino acid-based poly(ester urea)s crosslinked with osteogenic growth peptide with enhanced mechanical properties and bioactivity.

Journal Article Acta biomaterialia · February 2013 Materials currently used for the treatment of bone defects include ceramics, polymeric scaffolds and composites, which are often impregnated with recombinant growth factors and other bioactive substances. While these materials have seen instances of succes ... Full text Cite

2-D gold nanoparticle arrays from thermally directed self-assembly of peptide-derivatized block copolymers

Journal Article Soft Matter · January 1, 2013 Collective surface plasmons (SPs) generated by two-dimensional (2-D) Au nanostructures are attractive for developing miniaturized photonic devices with sub-wavelength plasmonic structures and bimolecular sensors with single molecule sensitivity. However, h ... Full text Cite

Post-assembly derivatization of electrospun nanofibers via strain-promoted azide alkyne cycloaddition.

Journal Article Journal of the American Chemical Society · October 2012 A primary amine-derivatized 4-dibenzocyclooctynol (DIBO) was used to initiate the ring-opening polymerization of poly(γ-benzyl-L-glutamate) (DIBO-PBLG). This initiator yields well-defined PBLG polymers functionalized with DIBO at the chain termini. The DIB ... Full text Cite

High-content imaging-based screening of microenvironment-induced changes to stem cells.

Journal Article Journal of biomolecular screening · October 2012 Effective screening methodologies for cells are challenged by the divergent and heterogeneous nature of phenotypes inherent to stem cell cultures, particularly on engineered biomaterial surfaces. In this study, we showcase a high-content, confocal imaging- ... Full text Cite

How melt-stretching affects mechanical behavior of polymer glasses

Journal Article Macromolecules · August 28, 2012 This work takes a simple phenomenological approach to the questions of when, how, and why a brittle polymer glass turns ductile and vice versa. Perceiving a polymer glass as a hybrid, we recognize that both the primary structure formed by van der Waals for ... Full text Cite

Strain-promoted cross-linking of PEG-based hydrogels via copper- free cycloaddition

Journal Article ACS Macro Letters · August 21, 2012 The synthesis of a 4-dibenzocyclooctynol (DIBO) functionalized poly(ethylene glycol) (PEG) and fabrication of hydrogels via strain-promoted, metal-free, azide-alkyne cycloaddition is reported. The resulting hydrogel materials provide a versatile alternativ ... Full text Cite

ECM production of primary human and bovine chondrocytes in hybrid PEG hydrogels containing type I collagen and hyaluronic acid.

Journal Article Biomacromolecules · May 2012 The development of advanced materials that facilitate hyaline cartilage formation and regeneration in aging populations is imperative. Critical to the success of this endeavor is the optimization of ECM production from clinically relevant cells. However, m ... Full text Cite

High-fidelity fabrication of Au-polymer Janus nanoparticles using a solution template approach

Journal Article Soft Matter · March 14, 2012 Janus particles have attracted significant attention in recent years, due to their potential in nanomanufacturing. Their asymmetric features impart unique physical and chemical properties, which can be tuned and utilized to control their solution-state ass ... Full text Cite

The influence of amino acid sequence and functionality on the binding process of peptides onto gold surfaces.

Journal Article Langmuir : the ACS journal of surfaces and colloids · January 2012 We present a molecular dynamics study of the binding process of peptide A3 (AYSSGAPPMPPF) and other similar peptides onto gold surfaces, and identify the functions of many amino acids. Our results provide a clear picture of the separate regimes present in ... Full text Cite

Synergistic enhancement of human bone marrow stromal cell proliferation and osteogenic differentiation on BMP-2-derived and RGD peptide concentration gradients.

Journal Article Acta biomaterialia · May 2011 Rational design of bioactive tissue engineered scaffolds for directing bone regeneration in vivo requires a comprehensive understanding of cell interactions with the immobilized bioactive molecules. In the current study, substrates possessing gradient conc ... Full text Cite

Carbon nanotubes: measuring dispersion and length.

Journal Article Advanced materials (Deerfield Beach, Fla.) · January 2011 Advanced technological uses of single-walled carbon nanotubes (SWCNTs) rely on the production of single length and chirality populations that are currently only available through liquid-phase post processing. The foundation of all of these processing steps ... Full text Cite

Advancing SPRi measurements with novel biosensors for studying surface-biomolecule interactions

Conference ACS Symposium Series · November 18, 2010 Through years of scientific research and development, surface plasmon resonance (SPR) has become a sensitive, quantitative and rapid measurement method with abundant applications in the fields of biology and biomaterials. The present contribution provides ... Full text Cite

The modulation of dendritic cell integrin binding and activation by RGD-peptide density gradient substrates.

Journal Article Biomaterials · October 2010 Dendritic cells (DCs) are central regulators of the immune system that operate in both innate and adaptive branches of immunity. Activation of DC by numerous factors, such as danger signals, has been well established. However, modulation of DC functions th ... Full text Cite

Quantification of the binding affinity of a specific hydroxyapatite binding peptide.

Journal Article Biomaterials · April 2010 The genesis of bone and teeth involves highly coordinated processes, which involve multiple cell types and proteins that direct the nucleation and crystallization of inorganic hydroxyapatite (HA). Recent studies have shown that peptides mediate the nucleat ... Full text Cite

Characterization of non-equilibrium nanoparticle adsorption on a model biological substrate.

Journal Article Langmuir : the ACS journal of surfaces and colloids · April 2010 The kinetics of nanoparticle (NP) adsorption on a model biological interface (collagen) is measured in microfluidic channels using surface plasmon resonance (SPR) imaging over a range of CdSe/ZnS quantum dot concentrations to investigate the underlying bin ... Full text Cite

The use of immobilized osteogenic growth peptide on gradient substrates synthesized via click chemistry to enhance MC3T3-E1 osteoblast proliferation.

Journal Article Biomaterials · March 2010 In this study, we report the use of surface immobilized peptide concentration gradient technology to characterize MC3T3-E1 osteoblast cell response to osteogenic growth peptide (OGP), a small peptide found naturally in human serum at mumol/L concentrations ... Full text Cite

Fluorinated copolymer nanoparticles for multimodal imaging applications

Journal Article Macromolecular Rapid Communications · January 4, 2010 Nanomaterials have emerged as valuable tools in biomedical imaging techniques. Here, the synthesis and characterization of a novel fluorinated nanoparticle with potential applications as an MRI contrast agent is reported. Particles were synthesized using a ... Full text Cite

Interaction of gold nanoparticles with common human blood proteins.

Journal Article ACS nano · January 2010 In order to better understand the physical basis of the biological activity of nanoparticles (NPs) in nanomedicine applications and under conditions of environmental exposure, we performed an array of photophysical measurements to quantify the interaction ... Full text Cite

The effect of dispersant on defects in length-separated single-wall carbon nanotubes measured by Raman spectroscopy

Journal Article Carbon · November 1, 2009 The fluorescence quantum yield of single-wall carbon nanotubes (SWCNTs) in solution depends dramatically on dispersant. To evaluate the role of defects in this dependence, we compare Raman spectra from aqueous suspensions of SWCNTs dispersed using either s ... Full text Cite

Improved methods and standards for telomerase detection: quantitative histopathology using antibody staining.

Journal Article Biotechnic & histochemistry : official publication of the Biological Stain Commission · October 2009 Evaluation of telomerase as an early detection biomarker for cancer has been hindered by a lack of reliable methods and standards for in situ histochemical measurement. Improved histochemical methods for measuring telomerase could expedite the acceptance o ... Full text Cite

Inhibitory effects of a phage-derived peptide on Au nanocrystal nucleation and growth.

Journal Article Langmuir : the ACS journal of surfaces and colloids · September 2009 Peptides have been shown to mediate the reduction and clustering of inorganic ions during biomineralization processes to build nanomaterials with well-defined shape, size, and composition. This precise control has been linked to specific amino acid sequenc ... Full text Cite

Impact of polymer-bound iodine on fibronectin adsorption and osteoblast cell morphology in radiopaque medical polymers: tyrosine-derived polycarbonate blends as a model system.

Journal Article Biomacromolecules · September 2009 Imaging of polymer implants during surgical implantations is challenging in that most materials lack sufficient X-ray contrast. Synthetic derivatization with iodine serves to increase the scattering contrast but results in distinct physicochemical properti ... Full text Cite

High-content profiling of cell responsiveness to graded substrates based on combinyatorially variant polymers.

Journal Article Combinatorial chemistry & high throughput screening · August 2009 We have developed a novel approach combining high information and high throughput analysis to characterize cell adhesive responses to biomaterial substrates possessing gradients in surface topography. These gradients were fabricated by subjecting thin film ... Full text Cite

Thin film elastic modulus of degradable tyrosine-derived polycarbonate biomaterials and their blends

Journal Article Macromolecules · February 24, 2009 The integrity, function, and performance of biomedical devices having thin polymeric coatings are critically dependent on the mechanical properties of the film, including the elastic modulus. In this report, the elastic moduli of several tyrosine-derived p ... Full text Cite

Self-assembly of ordered nanowires in biological suspensions of single-wall carbon nanotubes.

Journal Article ACS nano · January 2009 We investigate the self-assembly of ordered nanowires from length-purified single-wall carbon nanotubes (SWCNTs) in aqueous suspensions of the biological surfactant sodium deoxycholate. Macroscopically straight and nearly periodic linear arrangements of al ... Full text Cite

Centrifugal length separation of carbon nanotubes

Journal Article Langmuir · December 16, 2008 Separation of single-wall carbon nanotubes (SWCNTs) by length via centrifugation in a high density medium, and the characterization of both the separated fractions and the centrifugation process are presented. Significant quantities of the separated SWCNTs ... Full text Cite

Identification of a highly-specific hydroxyapatite-binding peptide using phage display

Conference 8th World Biomaterials Congress 2008 · December 1, 2008 Cite

Bioactive surface gradients for combinatorial studies of cell adhesion

Conference 8th World Biomaterials Congress 2008 · December 1, 2008 Cite

Combinatorial polymer scaffold libraries for screening cell-biomaterial interactions in 3D

Journal Article Advanced Materials · June 4, 2008 A method for fabricating combinatorial libraries of polymer scaffolds was proposed for screening cell-biomaterial interactions in a three-dimensional (3D) format. The libraries used were of varying composition of two amorphous, biodegradable, biocompatible ... Full text Cite

Characterization and optimization of RGD-containing silk blends to support osteoblastic differentiation.

Journal Article Biomaterials · June 2008 The effect of blending two silk proteins, regenerated Bombyx mori fibroin and synthetic spidroin containing RGD, on silk film material structure (beta-sheet content) and properties (solubility), as well as on biological response (osteoblast adhesion, proli ... Full text Cite

Identification of a highly specific hydroxyapatite-binding peptide using phage display

Journal Article Advanced Materials · May 19, 2008 A study was conducted to identify a peptide sequence that show high-specific binding to crystalline hydroxyaptite. Hydroxyapatite is used to provide stationary phase in the chromatographic purification of amplified phage. The study used x-ray diffraction ( ... Full text Cite

Comparison of the quality of aqueous dispersions of single wall carbon nanotubes using surfactants and biomolecules.

Journal Article Langmuir : the ACS journal of surfaces and colloids · May 2008 The use of single wall carbon nanotubes (SWCNTs) in current and future applications depends on the ability to process SWCNTs in a solvent to yield high-quality dispersions characterized by individual SWCNTs and possessing a minimum of SWCNT bundles. Many a ... Full text Cite

Emission-tunable microwave synthesis of highly luminescent water soluble CdSe/ZnS quantum dots.

Journal Article Chemical communications (Cambridge, England) · May 2008 Water soluble CdSe/ZnS nanoparticles with emission maxima from 511 nm to 596 nm and quantum efficiencies ranging from 11% to 28% are synthesized in a facile two-step method in ambient atmospheric conditions using a commercially available microwave reactor. ... Full text Cite

X-ray imaging optimization of 3D tissue engineering scaffolds via combinatorial fabrication methods.

Journal Article Biomaterials · April 2008 We have developed a combinatorial method for determining optimum tissue scaffold composition for several X-ray imaging techniques. X-ray radiography and X-ray microcomputed tomography enable non-invasive imaging of implants in vivo and in vitro. However, h ... Full text Cite

Measurement of single-wall nanotube dispersion by size exclusion chromatography

Journal Article Journal of Physical Chemistry C · December 6, 2007 Size exclusion chromatography (SEC) is shown to be an effective method to characterize single-wall carbon nanotube (SWNT) dispersions. SEC separates nanotube dispersions by size, and an on-line viscosity detector gives intrinsic viscosity as a function of ... Full text Cite

Quantum Mazes: Luminescent Labyrinthine Semiconductor Nanocrystals Having a Narrow Emission Spectrum

Journal Article ACS Nano · November 1, 2007 We exploit the polytypism of group II-VI semiconductors and the long-range dipolar interactions typical of CdSe nanoparticle formation to modulate the geometrical structure and the optical emission properties of novel branched CdSe nanocrystals through sha ... Full text Cite

Length-dependent optical effects in single-wall carbon nanotubes

Journal Article Journal of the American Chemical Society · August 29, 2007 Among the novel chemical and physical attributes of single-wall carbon nanotubes (SWCNTs), the optical properties are perhaps the most compelling. Although much is known about how such characteristics depend on nanotube chirality and diameter, relatively l ... Full text Cite

Fabrication of combinatorial polymer scaffold libraries.

Journal Article The Review of scientific instruments · July 2007 We have designed a novel combinatorial research platform to help accelerate tissue engineering research. Combinatorial methods combine many samples into a single specimen to enable accelerated experimentation and discovery. The platform for fabricating com ... Full text Cite

Universal gradient substrates for "click" biofunctionalization

Journal Article Advanced Materials · April 6, 2007 A novel and versatile method for fabricating continuously variable concentration gradients of surface-conjugated biomolecules is reported. This technology utilizes graded UV oxidation of self-assembled monolayers (SAM) as well as converts the resulting car ... Full text Cite

Length-dependent uptake of DNA-wrapped single-walled carbon nanotubes

Journal Article Advanced Materials · April 6, 2007 Well-dispersed, separated length fractions by SEC, the exhaustive characterization of these fractions, and high concentration in toxicity data, which indicate a threshold on the length and corresponding toxicity of single-walled carbon nanotubes (SWNT)was ... Full text Cite

Macrophage response to methacrylate conversion using a gradient approach.

Journal Article Acta biomaterialia · March 2007 Incomplete conversion, an ongoing challenge facing photopolymerized methacrylate-based polymers, affects leachables as well as the resulting polymer network. As novel polymers and composites are developed, methods to efficiently screen cell response to the ... Full text Cite

Small-angle neutron scattering from labeled single-wall carbon nanotubes

Journal Article Macromolecules · April 4, 2006 Small-angle neutron scattering (SANS) is used with the "high- concentration" method to extract single-particle scattering from single-wall carbon nanotubes (SWNTs). The SWNT material was labeled by covalently attaching - C 4H 9 or - C 4D 9 groups by use of ... Full text Cite

Cellular response to phase-separated blends of tyrosine-derived polycarbonates.

Journal Article Journal of biomedical materials research. Part A · March 2006 Two-dimensional thin films consisting of homopolymer and discrete compositional blends of tyrosine-derived polycarbonates were prepared and characterized in an effort to elucidate the nature of different cell responses that were measured in vitro. The stru ... Full text Cite

Rheo-optical studies of carbon nanotube suspensions

Journal Article Journal of Chemical Physics · February 13, 2006 We use a polarization-modulation technique to investigate the optical anisotropy of multi- and single-wall carbon nanotubes suspended in a variety of solvents under simple shear flow. Measurements of birefringence and dichroism are performed as a function ... Full text Cite

Chromatographic separation of single wall carbon nanotubes

Conference Materials Research Society Symposium Proceedings · January 1, 2006 Size exclusion chromatography (SEC) is shown to be an effective method to characterize single wall carbon nanotube (SWNT) dispersions. SEC separates nanotube dispersions by size, and measures the intrinsic viscosity on-line as a function of hydrodynamic si ... Full text Cite

Colloidal particles coated and stabilized by DNA-wrapped carbon nanotubes.

Journal Article Langmuir : the ACS journal of surfaces and colloids · November 2005 Single-walled carbon nanotubes (SWNTs) are dispersed in water via wrapping with short segments of single-stranded DNA (ssDNA). Small angle neutron scattering suggests a power-law exponent that is consistent with clustered nanotubes and hence marginal stabi ... Full text Cite

An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution.

Journal Article Biomacromolecules · September 2005 Amphiphilic core-shell nanoparticles have drawn considerable interest in biomedical applications. The precise control over their physicochemical parameters and the ability to attach various ligands within specific domains suggest shell cross-linked (SCK) n ... Full text Cite

PNA-directed solution- And surface-assembly of shell crosslinked (SCK) nanoparticle conjugates

Journal Article Journal of Materials Chemistry · June 14, 2005 The conjugation of complementary peptide nucleic acid (PNA) sequences to well defined shell crosslinked (SCK) nanoparticles is reported as a mechanism by which to direct their self assembly into higher order structures via selective and tunable binding int ... Full text Cite

Clustering and solvation in poly(acrylic acid) polyelectrolyte solutions

Journal Article Macromolecules · March 8, 2005 The clustering phenomena and solvation effects in polyelectrolyte solutions of poly(acrylic acid) were investigated. The small-angle neutron scattering (SANS) technique was used to observe clustering and solvation properties. Solutions of 5% PAA in d-water ... Full text Cite

Functionalized micellar assemblies prepared via block copolymers synthesized by living free radical polymerization upon peptide-loaded resins.

Journal Article Biomacromolecules · January 2005 Hybrid peptidic-synthetic amphiphilic block copolymers, synthesized by living free radical polymerization (LFRP) on solid support, have been utilized as precursors for nanoscale materials possessing bio-available peptides. LFRP initiators, coupled to the p ... Full text Cite

Peptide-derivatized shell-cross-linked nanoparticles. 2. Biocompatibility evaluation.

Journal Article Bioconjugate chemistry · July 2004 The conjugation of the protein transduction domain (PTD) from the HIV-1 Tat protein to shell cross-linked (SCK) nanoparticles is a method to facilitate cell surface binding and transduction. In the previous report, the preparation, derivatization, and char ... Full text Cite

Peptide-derivatized shell-cross-linked nanoparticles. 1. Synthesis and characterization.

Journal Article Bioconjugate chemistry · July 2004 The conjugation of the protein transduction domain (PTD) from the HIV-1 Tat protein to shell-cross-linked (SCK) nanoparticles is reported as a method to facilitate cell surface binding and transduction of SCK nanoparticles. Attaching increasing numbers of ... Full text Cite

Synthesis, characterization, and bioavailability of mannosylated shell cross-linked nanoparticles.

Journal Article Biomacromolecules · May 2004 Saccharide-functionalized shell cross-linked (SCK) polymer micelles designed as polyvalent nanoscaffolds for selective interactions with receptors on Gram negative bacteria were constructed from mixed micelles composed of poly(acrylic acid-b-methyl acrylat ... Full text Cite

Peptide-polymer bioconjugates: hybrid block copolymers generated via living radical polymerizations from resin-supported peptides.

Journal Article Chemical communications (Cambridge, England) · January 2003 A novel strategy for the preparation of peptidic-synthetic bioconjugate block copolymers is based upon sequential condensation and living radical addition polymerizations, each performed upon a solid support. ... Full text Cite

Synthetic methodologies for the surface derivatization of shell crosslinked nanoparticles

Conference American Chemical Society, Polymer Preprints, Division of Polymer Chemistry · January 1, 2002 Cite

Biocompatible surface functionalized shell crosslinked nanoparticles for use in biological applications

Conference American Chemical Society, Polymer Preprints, Division of Polymer Chemistry · January 1, 2002 Cite

Diblock copolymers, micelles, and shell-crosslinked nanoparticles containing poly(4-fluorostyrene): Tools for detailed analyses of nanostructured materials

Journal Article Journal of Polymer Science, Part A: Polymer Chemistry · December 1, 2001 Amphiphilic core-shell nanostructures containing 19F stable isotopic labels located regioselectively within the core domain were prepared by a combination of atom transfer radical polymerization (ATRP), supramolecular assembly, and condensation-based cross ... Full text Cite

Radical-based preparation of block copolymers containing fluorine tags: tools for detailed analysis of nanostructured materials

Conference American Chemical Society, Polymer Preprints, Division of Polymer Chemistry · August 1, 2000 Homopolymers and diblock copolymers containing 4-flurostyrene and methyl acrylate were synthesized by ATRP. By using PMDETA as the coordinating ligand for the Cu1Br, diblock copolymers that have not been generated previously by other radical polymerization ... Cite