Scholars@Duke
Gerald Arthur Grant

Gerald Arthur Grant

Allan H. Friedman Distinguished Professor of Neurosurgery
Neurosurgery
gerald.grant@duke.edu
Duke Box 3271, Durham, NC 27710
1554A Duke South, Box 3271, Durham, NC 27710

Selected Publications

Variability in youth coach concussion education requirements across states.

Journal Article PM R · October 23, 2024 BACKGROUND: Youth sports coaches play a critical role in proper concussion recognition and management, reinforcing the need for coach concussion education. As of 2021, most states have statutory and policy measures mandating concussion education for coache ... Full text Link to item Cite

Padded Helmet Shell Covers in American Football: A Comprehensive Laboratory Evaluation with Preliminary On-Field Findings.

Journal Article Ann Biomed Eng · October 2024 Protective headgear effects measured in the laboratory may not always translate to the field. In this study, we evaluated the impact attenuation capabilities of a commercially available padded helmet shell cover in the laboratory and on the field. In the l ... Full text Open Access Link to item Cite

An international study presenting a federated learning AI platform for pediatric brain tumors.

Journal Article Nat Commun · September 2, 2024 While multiple factors impact disease, artificial intelligence (AI) studies in medicine often use small, non-diverse patient cohorts due to data sharing and privacy issues. Federated learning (FL) has emerged as a solution, enabling training across hospita ... Full text Link to item Cite

AI-Based Denoising of Head Impact Kinematics Measurements With Convolutional Neural Network for Traumatic Brain Injury Prediction.

Journal Article IEEE Trans Biomed Eng · September 2024 OBJECTIVE: Wearable devices are developed to measure head impact kinematics but are intrinsically noisy because of the imperfect interface with human bodies. This study aimed to improve the head impact kinematics measurements obtained from instrumented mou ... Full text Link to item Cite

The role of occipital condyle and atlas anomalies on occipital cervical fusion outcomes in Chiari malformation type I with syringomyelia: a study from the Park-Reeves Syringomyelia Research Consortium.

Journal Article J Neurosurg Pediatr · July 1, 2024 OBJECTIVE: Congenital anomalies of the atlanto-occipital articulation may be present in patients with Chiari malformation type I (CM-I). However, it is unclear how these anomalies affect the biomechanical stability of the craniovertebral junction (CVJ) and ... Full text Link to item Cite

Brain Deformation Estimation With Transfer Learning for Head Impact Datasets Across Impact Types.

Journal Article IEEE Trans Biomed Eng · June 2024 OBJECTIVE: The machine-learning head model (MLHM) to accelerate the calculation of brain strain and strain rate, which are the predictors for traumatic brain injury (TBI), but the model accuracy was found to decrease sharply when the training/test datasets ... Full text Link to item Cite

A wearable hydraulic shock absorber with efficient energy dissipation

Journal Article International Journal of Mechanical Sciences · May 15, 2024 Advances in shock absorber technology are often translated to wearable personal protective equipment (PPE) to protect humans from impact-related injuries. However, the effectiveness of PPE is limited by factors such as the tolerable size and weight of the ... Full text Open Access Cite

Factors Associated with Transfer Distance from Birth Hospital to Repair Hospital for First Surgical Repair among Infants with Myelomeningocele in California.

Journal Article Am J Perinatol · May 2024 OBJECTIVE: The objective of our study was to examine factors associated with distance to care for first surgical repair among infants with myelomeningocele in California. STUDY DESIGN: A total of 677 eligible cases with complete geocoded data were identifi ... Full text Link to item Cite

Neurosurgical Outcomes Among Non-English Speakers: A Systematic Review and a Framework for Future Research.

Journal Article World Neurosurg · May 2024 OBJECTIVE: In 2019, 22% of adults in the United States reported speaking a language other than English at home, representing 52% growth since 2000. This diversity in languages - and resulting possible communication barriers - represents a potential challen ... Full text Link to item Cite

Clinical Characteristics and Outcome of Patients With Intraoperative Aneurysm Rupture: A Retrospective Cohort Study From Nepal

Journal Article Neurosurgery Practice · February 16, 2024 BACKGROUND AND OBJECTIVES: Intraoperative aneurysm rupture (IAR) is a significant complication during microsurgical clipping of cerebral aneurysms. The timing of rupture during surgery, morphology of the aneurysm, and strategies to mitigate risk are the ke ... Full text Cite

Approach, complications, and outcomes for 37 consecutive pediatric patients undergoing laser ablation for medically refractory epilepsy at Stanford Children's Health.

Journal Article J Neurosurg Pediatr · January 1, 2024 OBJECTIVE: The objective of this study was to better understand the safety and efficacy of laser interstitial thermal therapy (LITT) for children with medically refractory epilepsy. METHODS: Thirty-seven consecutive pediatric epilepsy patients at a single ... Full text Link to item Cite

Expanding eligibility for intracranial electroencephalography using Dexmedetomidine Hydrochloride in children with behavioral dyscontrol.

Journal Article Epilepsy Behav · January 2024 INTRODUCTION: Invasive intracranial electroencephalography (IEEG) is advantageous for identifying epileptogenic foci in pediatric patients with medically intractable epilepsy. Patients with behavioral challenges due to autism, intellectual disabilities, an ... Full text Open Access Link to item Cite

A study protocol for risk stratification in children with concussion (RSiCC): Theoretical framework, design, and methods.

Journal Article PLoS One · 2024 Research shows that one in five children will experience a concussion by age 16. Compared to adults, children experience longer and more severe postconcussive symptoms (PCS), with severity and duration varying considerably among children and complicating m ... Full text Link to item Cite

Disparities in Postoperative Communication Patterns Among Spanish-speaking Pediatric Patients with Hydrocephalus.

Journal Article J Pediatr · December 2023 OBJECTIVE: To determine if differences exist in postoperative communication patterns or healthcare use among English-speaking patients (ESPs) and Spanish-speaking patients (SSPs) with childhood hydrocephalus. STUDY DESIGN: A single-institution, retrospecti ... Full text Link to item Cite

Immune cell identity behind the Ktrans mapping of mouse glioblastoma.

Journal Article Magn Reson Imaging · November 2023 Dynamic contrast-enhanced MR imaging (DCE-MRI) can assess the integrity of the blood brain barrier (BBB) and has been used in GBM patients to determine glioma grade, predict prognosis, evaluate treatment response, and differentiate treatment-induced effect ... Full text Link to item Cite

Promoting diversity in neurosurgery through a virtual symposium.

Journal Article J Neurosurg · October 1, 2023 OBJECTIVE: The rates of women and underrepresented racial and ethnic minority (UREM) students successfully matching into neurosurgical residency are extremely low and do not reflect the makeup of the general population. As of 2019, only 17.5% of neurosurgi ... Full text Link to item Cite

Machine-learning-based head impact subtyping based on the spectral densities of the measurable head kinematics.

Journal Article J Sport Health Sci · September 2023 BACKGROUND: Traumatic brain injury can be caused by head impacts, but many brain injury risk estimation models are not equally accurate across the variety of impacts that patients may undergo, and the characteristics of different types of impacts are not w ... Full text Open Access Link to item Cite

Longitudinal Alterations of Cerebral Blood Flow in High-Contact Sports.

Journal Article Ann Neurol · September 2023 OBJECTIVE: Repetitive head trauma is common in high-contact sports. Cerebral blood flow (CBF) can measure changes in brain perfusion that could indicate injury. Longitudinal studies with a control group are necessary to account for interindividual and deve ... Full text Link to item Cite

Microstructural Alterations in Tract Development in College Football and Volleyball Players: A Longitudinal Diffusion MRI Study.

Journal Article Neurology · August 29, 2023 BACKGROUND AND OBJECTIVES: Repeated impacts in high-contact sports such as American football can affect the brain's microstructure, which can be studied using diffusion MRI. Most imaging studies are cross-sectional, do not include low-contact players as co ... Full text Link to item Cite

Clinical Applications of Immunotherapy for Recurrent Glioblastoma in Adults.

Journal Article Cancers (Basel) · July 31, 2023 Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. Despite standard therapies, including resection and chemoradiation, recurrence is virtually inevitable. Current treatment for recurrent glioblastoma (rGBM) is rapidly evolving, ... Full text Link to item Cite

Vein of Galen malformations in the newborn: case series.

Journal Article J Neurosurg Case Lessons · June 12, 2023 BACKGROUND: Vein of Galen malformations (VoGMs) in newborns often represent life-threatening emergencies. Outcome is difficult to predict. The authors review 50 VoGM cases to correlate anatomical types with treatment and outcome. OBSERVATIONS: Four distinc ... Full text Link to item Cite

Molecular Identity Changes of Tumor-Associated Macrophages and Microglia After Magnetic Resonance Imaging-Guided Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Mouse Glioblastoma Model.

Journal Article Ultrasound Med Biol · May 2023 An orthotopically allografted mouse GL26 glioma model (Ccr2RFP/wt-Cx3cr1GFP/wt) was used to evaluate the effect of transient, focal opening of the blood-brain barrier (BBB) on the composition of tumor-associated macrophages and microglia (TAMs). BBB openin ... Full text Open Access Link to item Cite

Multidisciplinary Stroke Pathway for Children Supported With Ventricular Assist Devices.

Journal Article ASAIO J · April 1, 2023 Mechanical circulatory support (MCS), including ventricular assist device (VAD) support, is a leading cause of stroke in children; however, existing pediatric stroke recommendations do not apply to many pediatric VAD patients. We sought to develop a multid ... Full text Open Access Link to item Cite

Clinical Features, Neuropathology, and Surgical Outcome in Patients With Refractory Epilepsy and Brain Somatic Variants in the SLC35A2 Gene.

Journal Article Neurology · January 31, 2023 BACKGROUND AND OBJECTIVES: The SLC35A2 gene, located at chromosome Xp11.23, encodes for a uridine diphosphate-galactose transporter. We describe clinical, genetic, neuroimaging, EEG, and histopathologic findings and assess possible predictors of postoperat ... Full text Open Access Link to item Cite

The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science.

Journal Article Neoplasia · January 2023 Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side e ... Full text Open Access Link to item Cite

Treatment Course and Outcomes of Intracranial Teratomas in Pediatric Patients: A Retrospective 15-Year Case Series Study.

Journal Article Pediatr Neurosurg · 2023 INTRODUCTION: There is no standard treatment paradigm for intracranial teratomas, a rare subset of primary intracranial non-germinomatous germ cell tumors (NGGCT), which comprise less than 1% of pediatric brain tumors. This case series retrospectively anal ... Full text Link to item Cite

Translational models of mild traumatic brain injury tissue biomechanics

Journal Article Current Opinion in Biomedical Engineering · December 1, 2022 Traumatic brain injury (TBI) is a global health concern. Mild TBI (mTBI) which accounts for the majority of TBI cases, is hard to detect since often the imaging is normal but can still cause brain damage and long-term sequelae. Physiologically, acute prima ... Full text Open Access Cite

EXTH-96. BIOPROCESSING OF SURGICAL PEDIATRIC BRAIN TUMOR SPECIMENS FOR GENOME-GUIDED PERSONALIZED DRUG TESTING

Journal Article Neuro-Oncology · November 14, 2022 AbstractNovel treatment approaches for pediatric central nervous system (CNS) tumors are urgently needed. A lack of patient-derived tumor cells impedes progress towards developing such new therapies. We inte ... Full text Cite

STEM-15. THERAPY-INDUCED CHANGES BY BRAF AND MEK INHIBITORS IN BRAF V600E-MUTATED GLIOMA MODELS PROVIDE POTENTIAL NOVEL THERAPEUTIC OPPORTUNITIES

Journal Article Neuro-Oncology · November 14, 2022 AbstractCombinations of the MEK inhibitor trametinib, and BRAF inhibitor dabrafenib (BRAFi+MEKi) show rapid and sustained responses in patients with BRAF V600E-mutated low-grade glioma, but tumor rebound aft ... Full text Cite

Piecewise Multivariate Linearity Between Kinematic Features and Cumulative Strain Damage Measure (CSDM) Across Different Types of Head Impacts.

Journal Article Ann Biomed Eng · November 2022 In a previous study, we found that the relationship between brain strain and kinematic features cannot be described by a generalized linear model across different types of head impacts. In this study, we investigate if such a linear relationship exists whe ... Full text Open Access Link to item Cite

Intracranial Artery Morphology in Pediatric Moya Moya Disease and Moya Moya Syndrome.

Journal Article Neurosurgery · November 1, 2022 BACKGROUND: Moya Moya disease (MMD) and Moya Moya syndrome (MMS) are cerebrovascular disorders, which affect the internal carotid arteries (ICAs). Diagnosis and surveillance of MMD/MMS in children mostly rely on qualitative evaluation of vascular imaging, ... Full text Open Access Link to item Cite

Stereotactic radiosurgery for recurrent pediatric brain tumors: clinical outcomes and toxicity.

Journal Article Neurosurg Focus · November 2022 OBJECTIVE: Recurrence of brain tumors in children after the initial course of treatment remains a problem. This study evaluated the efficacy and safety of reirradiation using stereotactic radiosurgery (SRS) in patients with recurrent pediatric primary brai ... Full text Link to item Cite

Factors for Differential Outcome Across Cancers in Clinical Molecule-Targeted Fluorescence Imaging.

Journal Article J Nucl Med · November 2022 Clinical imaging performance using a fluorescent antibody was compared across 3 cancers to elucidate physical and biologic factors contributing to differential translation of epidermal growth factor receptor (EGFR) expression to macroscopic fluorescence in ... Full text Open Access Link to item Cite

Finding the Spatial Co-Variation of Brain Deformation With Principal Component Analysis.

Journal Article IEEE Trans Biomed Eng · October 2022 OBJECTIVE: Strain and strain rate are effective traumatic brain injury metrics. In finite element (FE) head model, thousands of elements were used to represent the spatial distribution of these metrics. Owing that these metrics are resulted from brain iner ... Full text Link to item Cite

Maturation and circuit integration of transplanted human cortical organoids.

Journal Article Nature · October 2022 Self-organizing neural organoids represent a promising in vitro platform with which to model human development and disease1-5. However, organoids lack the connectivity that exists in vivo, which limits maturation and makes integration with other circuits t ... Full text Link to item Cite

Optimizing the residency application process: insights from neurological surgery during the pandemic virtual application cycle.

Journal Article J Neurosurg · September 1, 2022 OBJECTIVE: In this article, the authors describe the impact of the COVID-19 virtual match cycle and discuss approaches to optimize future cycles through applicant and neurosurgical education leadership insights. METHODS: Anonymous surveys of neurosurgery p ... Full text Link to item Cite

Laboratory And On-field Testing Of A Commercially Available Padded Helmet Cover

Journal Article Medicine & Science in Sports & Exercise · September 2022 Full text Cite

Somatic variants in diverse genes leads to a spectrum of focal cortical malformations.

Journal Article Brain · August 27, 2022 Post-zygotically acquired genetic variants, or somatic variants, that arise during cortical development have emerged as important causes of focal epilepsies, particularly those due to malformations of cortical development. Pathogenic somatic variants have ... Full text Link to item Cite

MRI Radiogenomics of Pediatric Medulloblastoma: A Multicenter Study.

Journal Article Radiology · August 2022 Background Radiogenomics of pediatric medulloblastoma (MB) offers an opportunity for MB risk stratification, which may aid therapeutic decision making, family counseling, and selection of patient groups suitable for targeted genetic analysis. Purpose To de ... Full text Link to item Cite

Hydrocephalus surveillance following CSF diversion: a modified Delphi study.

Journal Article J Neurosurg Pediatr · August 1, 2022 OBJECTIVE: Long-term follow-up is often recommended for patients with hydrocephalus, but the frequency of clinical follow-up, timing and modality of imaging, and duration of surveillance have not been clearly defined. Here, the authors used the modified De ... Full text Link to item Cite

Complications and outcomes of posterior fossa decompression with duraplasty versus without duraplasty for pediatric patients with Chiari malformation type I and syringomyelia: a study from the Park-Reeves Syringomyelia Research Consortium.

Journal Article J Neurosurg Pediatr · July 1, 2022 OBJECTIVE: The aim of this study was to determine differences in complications and outcomes between posterior fossa decompression with duraplasty (PFDD) and without duraplasty (PFD) for the treatment of pediatric Chiari malformation type I (CM1) and syring ... Full text Link to item Cite

Increased utilization of healthcare services in children with craniosynostosis.

Journal Article J Neurosurg Pediatr · July 1, 2022 OBJECTIVE: Craniosynostosis is characterized by the premature fusion of at least one cranial suture. Although evidence suggests that patients with both syndromic and nonsyndromic craniosynostosis may benefit from developmental, behavioral, and mental healt ... Full text Link to item Cite

Applying to residency: survey of neurosurgical residency applicants on virtual recruitment during COVID-19.

Journal Article J Neurosurg · July 1, 2022 OBJECTIVE: The COVID-19 pandemic caused a significant disruption to residency recruitment, including a sudden, comprehensive transition to virtual interviews. The authors sought to characterize applicant experiences and perceptions concerning the change in ... Full text Link to item Cite

Abstract CT001: Major tumor regressions in H3K27M-mutated diffuse midline glioma (DMG) following sequential intravenous (IV) and intracerebroventricular (ICV) delivery of GD2-CAR T cells

Journal Article Cancer Research · June 15, 2022 AbstractBackground: H3K27M-mutated DMGs are universally lethal central nervous system tumors that express high levels of the disialoganglioside GD2. IV administered GD2-CAR T cells (GD2-CART) regress DMG in ... Full text Cite

DIPG-15. Major tumor regressions in H3K27M-mutated diffuse midline glioma (DMG) following sequential intravenous (IV) and intracerebroventricular (ICV) delivery of GD2-CAR T-cells

Journal Article Neuro-Oncology · June 3, 2022 AbstractBACKGROUND: H3K27M-mutated DMGs express high levels of the disialoganglioside GD2 and GD2-CAR T-cells (GD2-CART) regress DMG in preclinical models. METHODS: NCT04196413 is a 3 + 3 Phase I dose escala ... Full text Cite

Age-dependent white matter disruptions after military traumatic brain injury: Multivariate analysis results from ENIGMA brain injury.

Journal Article Hum Brain Mapp · June 1, 2022 Mild Traumatic brain injury (mTBI) is a signature wound in military personnel, and repetitive mTBI has been linked to age-related neurogenerative disorders that affect white matter (WM) in the brain. However, findings of injury to specific WM tracts have b ... Full text Open Access Link to item Cite

Radiomic signatures of posterior fossa ependymoma: Molecular subgroups and risk profiles.

Journal Article Neuro Oncol · June 1, 2022 BACKGROUND: The risk profile for posterior fossa ependymoma (EP) depends on surgical and molecular status [Group A (PFA) versus Group B (PFB)]. While subtotal tumor resection is known to confer worse prognosis, MRI-based EP risk-profiling is unexplored. We ... Full text Link to item Cite

Radiomics Can Distinguish Pediatric Supratentorial Embryonal Tumors, High-Grade Gliomas, and Ependymomas.

Journal Article AJNR Am J Neuroradiol · April 2022 BACKGROUND AND PURPOSE: Pediatric supratentorial tumors such as embryonal tumors, high-grade gliomas, and ependymomas are difficult to distinguish by histopathology and imaging because of overlapping features. We applied machine learning to uncover MR imag ... Full text Link to item Cite

Acetazolamide-Challenged Arterial Spin Labeling Detects Augmented Cerebrovascular Reserve After Surgery for Moyamoya.

Journal Article Stroke · April 2022 BACKGROUND: Cerebrovascular reserve (CVR) inversely correlates with stroke risk in children with Moyamoya disease and may be improved by revascularization surgery. We hypothesized that acetazolamide-challenged arterial spin labeling MR perfusion quantifies ... Full text Link to item Cite

An integrated risk model stratifying seizure risk following brain tumor resection among seizure-naive patients without antiepileptic prophylaxis.

Journal Article Neurosurg Focus · April 2022 OBJECTIVE: The natural history of seizure risk after brain tumor resection is not well understood. Identifying seizure-naive patients at highest risk for postoperative seizure events remains a clinical need. In this study, the authors sought to develop a p ... Full text Link to item Cite

Development of an integrated risk scale for prediction of shunt placement after neonatal intraventricular hemorrhage.

Journal Article J Neurosurg Pediatr · April 1, 2022 OBJECTIVE: Neonatal intraventricular hemorrhage (IVH) is a major cause of mortality and morbidity, particularly following premature birth. Even after the acute phase, posthemorrhagic hydrocephalus is a long-term complication, frequently requiring permanent ... Full text Link to item Cite

Antiseizure medication use and medical resource utilization after resective epilepsy surgery in children in the United States: A contemporary nationwide cross-sectional cohort analysis.

Journal Article Epilepsia · April 2022 OBJECTIVE: Antiseizure drug (ASD) therapy can significantly impact quality of life for pediatric patients whose epilepsy remains refractory to medications and who experience neuropsychological side effects manifested by impaired cognitive and social develo ... Full text Link to item Cite

The Presence of the Temporal Horn Exacerbates the Vulnerability of Hippocampus During Head Impacts

Journal Article Frontiers in Bioengineering and Biotechnology · March 22, 2022 Hippocampal injury is common in traumatic brain injury (TBI) patients, but the underlying pathogenesis remains elusive. In this study, we hypothesize that the presence of the adjacent fluid-containing temporal horn exacerbates the biomechanical vulnerabili ... Full text Cite

Socioeconomic and demographic factors in the diagnosis and treatment of Chiari malformation type I and syringomyelia.

Journal Article J Neurosurg Pediatr · March 1, 2022 OBJECTIVE: The goal of this study was to assess the social determinants that influence access and outcomes for pediatric neurosurgical care for patients with Chiari malformation type I (CM-I) and syringomyelia (SM). METHODS: The authors used retro- and pro ... Full text Link to item Cite

GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas.

Journal Article Nature · March 2022 Diffuse intrinsic pontine glioma (DIPG) and other H3K27M-mutated diffuse midline gliomas (DMGs) are universally lethal paediatric tumours of the central nervous system1. We have previously shown that the disialoganglioside GD2 is highly expressed on H3K27M ... Full text Open Access Link to item Cite

Age-dependent Intracranial Artery Morphology in Healthy Children.

Journal Article Clin Neuroradiol · March 2022 PURPOSE: Evaluation of intracranial artery morphology plays an important role in diagnosing a variety of neurovascular diseases. In addition to clinical symptoms, diagnosis currently relies on qualitative rather than quantitative evaluation of vascular ima ... Full text Link to item Cite

Human Astrocytes Exhibit Tumor Microenvironment-, Age-, and Sex-Related Transcriptomic Signatures.

Journal Article J Neurosci · February 23, 2022 Astrocytes are critical for the development and function of synapses. There are notable species differences between human astrocytes and commonly used animal models. Yet, it is unclear whether astrocytic genes involved in synaptic function are stable or ex ... Full text Link to item Cite

Incorporating patient-centered quality-of-life measures for outcome assessment after Chiari malformation type I decompression in a pediatric population: a pilot study.

Conference J Neurosurg Pediatr · February 1, 2022 OBJECTIVE: Optimal management of pediatric Chiari malformation type I (CM-I) is much debated, chiefly due to the lack of validated tools for outcome assessment, with very few tools incorporating patient-centered measures of health-related quality of life ( ... Full text Link to item Cite

Management of Severe Traumatic Brain Injury in Pediatric Patients.

Journal Article Front Toxicol · 2022 The optimal management of severe traumatic brain injury (TBI) in the pediatric population has not been well studied. There are a limited number of research articles studying the management of TBI in children. Given the prevalence of severe TBI in the pedia ... Full text Open Access Link to item Cite

Improved prediction of postoperative pediatric cerebellar mutism syndrome using an artificial neural network.

Journal Article Neurooncol Adv · 2022 BACKGROUND: Postoperative pediatric cerebellar mutism syndrome (pCMS) is a common but severe complication that may arise following the resection of posterior fossa tumors in children. Two previous studies have aimed to preoperatively predict pCMS, with var ... Full text Open Access Link to item Cite

Spatiotemporal changes in along-tract profilometry of cerebellar peduncles in cerebellar mutism syndrome.

Journal Article Neuroimage Clin · 2022 Cerebellar mutism syndrome, characterised by mutism, emotional lability and cerebellar motor signs, occurs in up to 39% of children following resection of medulloblastoma, the most common malignant posterior fossa tumour of childhood. Its pathophysiology r ... Full text Open Access Link to item Cite

The current landscape of immunotherapy for pediatric brain tumors.

Journal Article Nat Cancer · January 2022 Pediatric central nervous system tumors are the most common solid malignancies in childhood, and aggressive therapy often leads to long-term sequelae in survivors, making these tumors challenging to treat. Immunotherapy has revolutionized prospects for man ... Full text Link to item Cite

Rationale and Methods for Updated Guidelines for the Management of Penetrating Traumatic Brain Injury.

Journal Article Neurotrauma Rep · 2022 Penetrating traumatic brain injury (pTBI) affects civilian and military populations resulting in significant morbidity, mortality, and healthcare costs. No up-to-date and evidence-based guidelines exist to assist modern medical and surgical management of t ... Full text Link to item Cite

Rapid intraoperative diagnosis of pediatric brain tumors using Raman spectroscopy: A machine learning approach

Journal Article Neuro-Oncology Advances · January 1, 2022 Background: Surgical resection is a mainstay in the treatment of pediatric brain tumors to achieve tissue diagnosis and tumor debulking. While maximal safe resection of tumors is desired, it can be challenging to differentiate normal brain from neoplastic ... Full text Cite

Hydrocephalus and Shunt Failure

Chapter · January 1, 2022 Failure is a common complication of ventricular shunt placement for hydrocephalus, with myriad presentations that are essential for emergency providers to identify. Patients in failure may present with acute or chronic symptoms ranging from headache to acu ... Full text Cite

An Atlas of the Quantitative Protein Expression of Anti-Epileptic-Drug Transporters, Metabolizing Enzymes and Tight Junctions at the Blood-Brain Barrier in Epileptic Patients.

Journal Article Pharmaceutics · December 9, 2021 The purpose of the present study was to quantitatively elucidate the levels of protein expression of anti-epileptic-drug (AED) transporters, metabolizing enzymes and tight junction molecules at the blood-brain barrier (BBB) in the focal site of epilepsy pa ... Full text Open Access Link to item Cite

Status epilepticus after intracranial neurosurgery: incidence and risk stratification by perioperative clinical features.

Journal Article J Neurosurg · December 1, 2021 OBJECTIVE: Status epilepticus (SE) is associated with significant mortality, cost, and risk of future seizures. In one of the first studies of SE after neurosurgery, the authors assess the incidence, risk factors, and outcome of postneurosurgical SE (PNSE) ... Full text Link to item Cite

Toward a Comprehensive Delineation of White Matter Tract-Related Deformation.

Journal Article J Neurotrauma · December 2021 Finite element (FE) models of the human head are valuable instruments to explore the mechanobiological pathway from external loading, localized brain response, and resultant injury risks. The injury predictability of these models depends on the use of effe ... Full text Link to item Cite

Participating in Two Video Concussion Education Programs Sequentially Improves Concussion-Reporting Intention

Journal Article Neurotrauma Reports · December 1, 2021 Undiagnosed concussions increase the risk of additional concussion and persistent symptoms from concussion. Because there are no reliable objective markers of concussion, self-reporting of subjective and non-visible symptoms are critical to ensuring proper ... Full text Cite

Real-World Preliminary Experience With Responsive Neurostimulation in Pediatric Epilepsy: A Multicenter Retrospective Observational Study.

Journal Article Neurosurgery · November 18, 2021 BACKGROUND: Despite the well-documented utility of responsive neurostimulation (RNS, NeuroPace) in adult epilepsy patients, literature on the use of RNS in children is limited. OBJECTIVE: To determine the real-world efficacy and safety of RNS in pediatric ... Full text Link to item Cite

Evaluating the Effect of Concussion-Education Programs on Intent to Report Concussion in High School Football.

Journal Article J Athl Train · November 1, 2021 CONTEXT: Concussion underreporting leads to delays in diagnosis and treatment, prolonging recovery time. Athletes' self-reporting of concussion symptoms, therefore, reduces risk. OBJECTIVE: To evaluate the effectiveness of 3 concussion-education programs i ... Full text Link to item Cite

Rapid Estimation of Entire Brain Strain Using Deep Learning Models.

Journal Article IEEE Trans Biomed Eng · November 2021 OBJECTIVE: Many recent studies suggest that brain deformation resulting from head impacts are linked to the corresponding clinical outcome, such as mild traumatic brain injury (mTBI). Even if several finite element (FE) head models have been developed and ... Full text Link to item Cite

Optimization of a Thermal Flow Meter for Failure Management of the Shunt in Pediatric Hydrocephalus Patients.

Conference Annu Int Conf IEEE Eng Med Biol Soc · November 2021 Hydrocephalus patients suffer from an abnormal buildup of cerebrospinal fluid (CSF) in their ventricles, and there is currently no known way to cure hydrocephalus. The most prevalent treatment for managing hydrocephalus is to implant a ventriculoperitoneal ... Full text Link to item Cite

Machine Assist for Pediatric Posterior Fossa Tumor Diagnosis: A Multinational Study.

Journal Article Neurosurgery · October 13, 2021 BACKGROUND: Clinicians and machine classifiers reliably diagnose pilocytic astrocytoma (PA) on magnetic resonance imaging (MRI) but less accurately distinguish medulloblastoma (MB) from ependymoma (EP). One strategy is to first rule out the most identifiab ... Full text Link to item Cite

Identifying Factors Associated with Head Impact Kinematics and Brain Strain in High School American Football via Instrumented Mouthguards.

Journal Article Ann Biomed Eng · October 2021 Repeated head impact exposure and concussions are common in American football. Identifying the factors associated with high magnitude impacts aids in informing sport policy changes, improvements to protective equipment, and better understanding of the brai ... Full text Link to item Cite

Factors Associated with Early Neonatal and First-Year Mortality in Infants with Myelomeningocele in California from 2006 to 2011.

Journal Article Am J Perinatol · October 2021 OBJECTIVE: The aim of this study is to examine factors associated with early neonatal (death within first 7 days of birth) and infant (death during the first year of life) mortality among infants born with myelomeningocele. STUDY DESIGN: We examined linked ... Full text Link to item Cite

Predictive Factors of Kinematics in Traumatic Brain Injury from Head Impacts Based on Statistical Interpretation.

Journal Article Ann Biomed Eng · October 2021 Brain tissue deformation resulting from head impacts is primarily caused by rotation and can lead to traumatic brain injury. To quantify brain injury risk based on measurements of kinematics on the head, finite element (FE) models and various brain injury ... Full text Link to item Cite

Time Window of Head Impact Kinematics Measurement for Calculation of Brain Strain and Strain Rate in American Football.

Journal Article Ann Biomed Eng · October 2021 Wearable devices have been shown to effectively measure the head's movement during impacts in sports like American football. When a head impact occurs, the device is triggered to collect and save the kinematic measurements during a predefined time window. ... Full text Link to item Cite

Radiomic Phenotypes Distinguish Atypical Teratoid/Rhabdoid Tumors from Medulloblastoma.

Journal Article AJNR Am J Neuroradiol · September 2021 BACKGROUND AND PURPOSE: Atypical teratoid/rhabdoid tumors and medulloblastomas have similar imaging and histologic features but distinctly different outcomes. We hypothesized that they could be distinguished by MR imaging-based radiomic phenotypes. MATERIA ... Full text Link to item Cite

Risk of secondary neoplasms after external-beam radiation therapy treatment of pediatric low-grade gliomas: a SEER analysis, 1973-2015.

Journal Article J Neurosurg Pediatr · September 1, 2021 OBJECTIVE: Although past studies have associated external-beam radiation therapy (EBRT) with higher incidences of secondary neoplasms (SNs), its effect on SN development from pediatric low-grade gliomas (LGGs), defined as WHO grade I and II gliomas of astr ... Full text Link to item Cite

Hybrid Fluoroscopic and Neurophysiological Targeting of Responsive Neurostimulation of the Rolandic Cortex.

Journal Article Oper Neurosurg (Hagerstown) · August 16, 2021 BACKGROUND: Precise targeting of cortical surface electrodes to epileptogenic regions defined by anatomic and electrophysiological guideposts remains a surgical challenge during implantation of responsive neurostimulation (RNS) devices. OBJECTIVE: To descr ... Full text Link to item Cite

Neuroradiologic Evaluation of MRI in High-Contact Sports

Journal Article Frontiers in Neurology · August 11, 2021 Background and Purpose: Athletes participating in high-contact sports experience repeated head trauma. Anatomical findings, such as a cavum septum pellucidum, prominent CSF spaces, and hippocampal volume reductions, have been observed in cases of mild trau ... Full text Cite

Extradural decompression versus duraplasty in Chiari malformation type I with syrinx: outcomes on scoliosis from the Park-Reeves Syringomyelia Research Consortium.

Journal Article J Neurosurg Pediatr · August 1, 2021 OBJECTIVE: Scoliosis is common in patients with Chiari malformation type I (CM-I)-associated syringomyelia. While it is known that treatment with posterior fossa decompression (PFD) may reduce the progression of scoliosis, it is unknown if decompression wi ... Full text Link to item Cite

Deep Brain Stimulation for Pediatric Dystonia.

Journal Article Semin Pediatr Neurol · July 2021 Dystonia is one of the most common pediatric movement disorders and can have a profound impact on the lives of children and their caregivers. Response to pharmacologic treatment is often unsatisfactory. Deep brain stimulation (DBS) has emerged as a promisi ... Full text Link to item Cite

Conformable hierarchically engineered polymeric micromeshes enabling combinatorial therapies in brain tumours.

Journal Article Nat Nanotechnol · July 2021 The poor transport of molecular and nanoscale agents through the blood-brain barrier together with tumour heterogeneity contribute to the dismal prognosis in patients with glioblastoma multiforme. Here, a biodegradable implant (μMESH) is engineered in the ... Full text Link to item Cite

White Matter Tract-Oriented Deformation Is Dependent on Real-Time Axonal Fiber Orientation.

Journal Article J Neurotrauma · June 15, 2021 Traumatic axonal injury (TAI) is a critical public health issue with its pathogenesis remaining largely elusive. Finite element (FE) head models are promising tools to bridge the gap between mechanical insult, localized brain response, and resultant injury ... Full text Link to item Cite

Long-term follow-up of neurosurgical outcomes for adult patients in Uganda with traumatic brain injury.

Journal Article J Neurosurg · June 1, 2021 OBJECTIVE: Traumatic brain injury (TBI) is a major cause of mortality and morbidity in Uganda and other low- and middle-income countries (LMICs). Due to the difficulty of long-term in-person follow-up, there is a paucity of literature on longitudinal outco ... Full text Link to item Cite

The relationship between brain injury criteria and brain strain across different types of head impacts can be different.

Journal Article J R Soc Interface · June 2021 Multiple brain injury criteria (BIC) are developed to quickly quantify brain injury risks after head impacts. These BIC originated from different head impact types (e.g. sports and car crashes) are widely used in risk evaluation. However, the accuracy of u ... Full text Link to item Cite

Gradient hydrogels for screening stiffness effects on patient-derived glioblastoma xenograft cellfates in 3D.

Journal Article J Biomed Mater Res A · June 2021 Brain cancer is a devastating disease given its extreme invasiveness and intricate location. Glioblastoma multiforme (GBM) is one of the most common forms of brain cancer, and cancer progression is often correlated with significantly altered tissue stiffne ... Full text Link to item Cite

A new open-access platform for measuring and sharing mTBI data.

Journal Article Sci Rep · April 5, 2021 Despite numerous research efforts, the precise mechanisms of concussion have yet to be fully uncovered. Clinical studies on high-risk populations, such as contact sports athletes, have become more common and give insight on the link between impact severity ... Full text Open Access Link to item Cite

A Computational Study of Liquid Shock Absorption for Prevention of Traumatic Brain Injury.

Journal Article J Biomech Eng · April 1, 2021 Mild traumatic brain injury (mTBI), more colloquially known as concussion, is common in contact sports such as American football, leading to increased scrutiny of head protective gear. Standardized laboratory impact testing, such as the yearly National Foo ... Full text Link to item Cite

Dural augmentation approaches and complication rates after posterior fossa decompression for Chiari I malformation and syringomyelia: a Park-Reeves Syringomyelia Research Consortium study.

Journal Article J Neurosurg Pediatr · April 1, 2021 OBJECTIVE: Posterior fossa decompression with duraplasty (PFDD) is commonly performed for Chiari I malformation (CM-I) with syringomyelia (SM). However, complication rates associated with various dural graft types are not well established. The objective of ... Full text Link to item Cite

An Analysis of Public Interest in Elective Neurosurgical Procedures During the COVID-19 Pandemic Through Online Search Engine Trends.

Journal Article World Neurosurg · April 2021 OBJECTIVE: In the wake of the COVID-19 pandemic, the Centers for Medicare & Medicaid Services (CMS) has recommended the temporary cessation of all elective surgeries. The effects on patients' interest of elective neurosurgical procedures are currently unex ... Full text Open Access Link to item Cite

Molecular imaging of a fluorescent antibody against epidermal growth factor receptor detects high-grade glioma.

Journal Article Sci Rep · March 11, 2021 The prognosis for high-grade glioma (HGG) remains dismal and the extent of resection correlates with overall survival and progression free disease. Epidermal growth factor receptor (EGFR) is a biomarker heterogeneously expressed in HGG. We assessed the fea ... Full text Open Access Link to item Cite

Matrix Stiffness Modulates Patient-Derived Glioblastoma Cell Fates in Three-Dimensional Hydrogels.

Journal Article Tissue Eng Part A · March 2021 Cancer progression is known to be accompanied by changes in tissue stiffness. Previous studies have primarily employed immortalized cell lines and 2D hydrogel substrates, which do not recapitulate the 3D tumor niche. How matrix stiffness affects patient-de ... Full text Link to item Cite

Artificial intelligence for automatic cerebral ventricle segmentation and volume calculation: a clinical tool for the evaluation of pediatric hydrocephalus.

Conference J Neurosurg Pediatr · February 1, 2021 OBJECTIVE: Imaging evaluation of the cerebral ventricles is important for clinical decision-making in pediatric hydrocephalus. Although quantitative measurements of ventricular size, over time, can facilitate objective comparison, automated tools for calcu ... Full text Link to item Cite

Adverse Events and Bundled Costs after Cranial Neurosurgical Procedures: Validation of the LACE Index Across 40,431 Admissions and Development of the LACE-Cranial Index.

Journal Article World Neurosurg · February 2021 OBJECTIVE: Anticipating postdischarge complications after neurosurgery remains difficult. The LACE index, based on 4 hospitalization descriptors, stratifies patients by risk of 30-day postdischarge adverse events but has not been validated in a procedure-s ... Full text Link to item Cite

Occipital-Cervical Fusion and Ventral Decompression in the Surgical Management of Chiari-1 Malformation and Syringomyelia: Analysis of Data From the Park-Reeves Syringomyelia Research Consortium.

Journal Article Neurosurgery · January 13, 2021 BACKGROUND: Occipital-cervical fusion (OCF) and ventral decompression (VD) may be used in the treatment of pediatric Chiari-1 malformation (CM-1) with syringomyelia (SM) as adjuncts to posterior fossa decompression (PFD) for complex craniovertebral junctio ... Full text Link to item Cite

Gene Expression Analysis in Three Posttraumatic Stress Disorder Cohorts Implicates Inflammation and Innate Immunity Pathways and Uncovers Shared Genetic Risk With Major Depressive Disorder.

Journal Article Front Neurosci · 2021 Posttraumatic stress disorder (PTSD) is a complex psychiatric disorder that can develop following exposure to traumatic events. The Psychiatric Genomics Consortium PTSD group (PGC-PTSD) has collected over 20,000 multi-ethnic PTSD cases and controls and has ... Full text Open Access Link to item Cite

Athlete Enjoyment of Prior Education Moderates change in Concussion-Reporting Intention after Interactive Education.

Journal Article Inquiry · 2021 Undiagnosed concussions increase risk of additional injuries and can prolong recovery. Because of the difficulties recognizing concussive symptoms, concussion education must specifically target improving athlete concussion reporting. Many concussion educat ... Full text Open Access Link to item Cite

Contemporaneous evaluation of patient experience, surgical strategy, and seizure outcomes in patients undergoing stereoelectroencephalography or subdural electrode monitoring.

Journal Article Epilepsia · January 2021 OBJECTIVE: Intracranial electrographic localization of the seizure onset zone (SOZ) can guide surgical approaches for medically refractory epilepsy patients, especially when the presurgical workup is discordant or functional cortical mapping is required. M ... Full text Link to item Cite

Early Effects of COVID-19 Pandemic on Neurosurgical Training in the United States: A Case Volume Analysis of 8 Programs.

Journal Article World Neurosurg · January 2021 OBJECTIVE: To determine the impact of the 2019 novel coronavirus disease (COVID-19) pandemic on operative case volume in 8 U.S. neurosurgical residency training programs in early 2020 and to survey these programs regarding training activities during this p ... Full text Open Access Link to item Cite

Influence of Instrumented Mouthguard Pre-trigger Time and Post-Trigger Time in Evaluating Brain Strain and Strain Rate in American Football Head Impacts

Conference Conference proceedings International Research Council on the Biomechanics of Injury, IRCOBI · January 1, 2021 Cite

Statistical Interpretation of Predictive Factors of Head Impact Kinematics in Traumatic Brain Injury

Conference Conference proceedings International Research Council on the Biomechanics of Injury, IRCOBI · January 1, 2021 Cite

Statistical Analysis of 18 Brain Injury Criteria in Evaluating Brain Strain on Different Types of Head Impact

Conference Conference proceedings International Research Council on the Biomechanics of Injury, IRCOBI · January 1, 2021 Cite

Head Model for Entire Brain Deformation Calculation in Real-time with Machine Learning

Conference Conference proceedings International Research Council on the Biomechanics of Injury, IRCOBI · January 1, 2021 Cite

Pediatric Neurovascular Conditions

Chapter · January 1, 2021 Pediatric neurovascular diseases can profoundly affect brain development, growth, and a child’s quality of life. Appropriately managing these conditions in children requires a thorough understanding of their etiologies, diagnoses, treatment options, and pr ... Full text Cite

Brain Iron Assessment after Ferumoxytol-enhanced MRI in Children and Young Adults with Arteriovenous Malformations: A Case-Control Study.

Journal Article Radiology · November 2020 Background Iron oxide nanoparticles are an alternative contrast agent for MRI. Gadolinium deposition has raised safety concerns, but it is unknown whether ferumoxytol administration also deposits in the brain. Purpose To investigate whether there are signa ... Full text Link to item Cite

Validation and Comparison of Instrumented Mouthguards for Measuring Head Kinematics and Assessing Brain Deformation in Football Impacts.

Journal Article Ann Biomed Eng · November 2020 Because of the rigid coupling between the upper dentition and the skull, instrumented mouthguards have been shown to be a viable way of measuring head impact kinematics for assisting in understanding the underlying biomechanics of concussions. This has led ... Full text Link to item Cite

Deep Learning for Automated Delineation of Pediatric Cerebral Arteries on Pre-operative Brain Magnetic Resonance Imaging

Journal Article Frontiers in Surgery · October 26, 2020 Introduction: Surgical resection of brain tumors is often limited by adjacent critical structures such as blood vessels. Current intraoperative navigations systems are limited; most are based on two-dimensional (2D) guidance systems that require manual seg ... Full text Cite

A comparative study of brain tumor cells from different age and anatomical locations using 3D biomimetic hydrogels.

Journal Article Acta Biomater · October 15, 2020 Brain tumors exhibit vast genotypic and phenotypic diversity depending on patient age and anatomical location. Hydrogels hold great promise as 3D in vitro models for studying brain tumor biology and drug screening, yet previous studies were limited to adul ... Full text Link to item Cite

Robust deep learning classification of adamantinomatous craniopharyngioma from limited preoperative radiographic images.

Journal Article Sci Rep · October 9, 2020 Deep learning (DL) is a widely applied mathematical modeling technique. Classically, DL models utilize large volumes of training data, which are not available in many healthcare contexts. For patients with brain tumors, non-invasive diagnosis would represe ... Full text Open Access Link to item Cite

Factors Associated with Timeliness of Surgical Repair among Infants with Myelomeningocele: California Perinatal Quality Care Collaborative, 2006 to 2011.

Journal Article Am J Perinatol · October 2020 OBJECTIVE: This study aimed to examine factors associated with timely (0-2 days after birth) myelomeningocele surgical repair. STUDY DESIGN: We examined 2006 to 2011 births from the California Perinatal Quality Care Collaborative, linking to hospital disch ... Full text Link to item Cite

Emergency department implementation of abbreviated magnetic resonance imaging for pediatric traumatic brain injury

Journal Article JACEP Open · October 1, 2020 Pediatric head injury is a common presenting complaint in the emergency department (ED), often requiring neuroimaging or ED observation for diagnosis. However, the traditional diagnostic neuroimaging modality, head computed tomography (CT), is associated w ... Full text Cite

Deep Learning for Pediatric Posterior Fossa Tumor Detection and Classification: A Multi-Institutional Study.

Journal Article AJNR Am J Neuroradiol · September 2020 BACKGROUND AND PURPOSE: Posterior fossa tumors are the most common pediatric brain tumors. MR imaging is key to tumor detection, diagnosis, and therapy guidance. We sought to develop an MR imaging-based deep learning model for posterior fossa tumor detecti ... Full text Link to item Cite

Neurosurgical Randomized Trials in Low- and Middle-Income Countries.

Journal Article Neurosurgery · September 1, 2020 BACKGROUND: The setting of a randomized trial can determine whether its findings are generalizable and can therefore apply to different settings. The contribution of low- and middle-income countries (LMICs) to neurosurgical randomized trials has not been s ... Full text Open Access Link to item Cite

Contributions of posttraumatic stress disorder (PTSD) and mild TBI (mTBI) history to suicidality in the INTRuST consortium.

Journal Article Brain Inj · August 23, 2020 OBJECTIVE: Mild TBI (mTBI) and posttraumatic stress disorder (PTSD) are independent risk factors for suicidal behaviour (SB). Further, co-occurring mTBI and PTSD increase one's risk for negative health and psychiatric outcomes. However, little research has ... Full text Link to item Cite

Longitudinal alteration of cortical thickness and volume in high-impact sports.

Journal Article Neuroimage · August 15, 2020 Collegiate football athletes are subject to repeated head impacts. The purpose of this study was to determine whether this exposure can lead to changes in brain structure. This prospective cohort study was conducted with up to 4 years of follow-up on 63 fo ... Full text Link to item Cite

Recurrence of cavernous malformations after surgery in childhood.

Journal Article J Neurosurg Pediatr · August 1, 2020 OBJECTIVE: Cavernous malformations (CMs) are commonly treated cerebrovascular anomalies in the pediatric population; however, the data on radiographic recurrence of pediatric CMs after surgery are limited. The authors aimed to study the clinical presentati ... Full text Link to item Cite

Variable Refocusing Flip Angle Single-Shot Imaging for Sedation-Free Fast Brain MRI.

Journal Article AJNR Am J Neuroradiol · July 2020 BACKGROUND AND PURPOSE: Conventional single-shot FSE commonly used for fast MRI may be suboptimal for brain evaluation due to poor image contrast, SNR, or image blurring. We investigated the clinical performance of variable refocusing flip angle single-sho ... Full text Link to item Cite

Pediatric neurosurgery training during residency in the United States: a program director survey.

Journal Article J Neurosurg Pediatr · July 1, 2020 OBJECTIVE: Pediatric neurosurgery is a core component of neurosurgical residency training. Pediatric case minimums are established by the Neurosurgery Residency Review Committee of the Accreditation Council for Graduate Medical Education (ACGME). Case mini ... Full text Link to item Cite

Endoscopic Endonasal Surgery for Resection of Giant Craniopharyngioma in a Toddler-Multimodal Presurgical Planning, Surgical Technique, and Management of Complications: 2-Dimensional Operative Video.

Journal Article Oper Neurosurg (Hagerstown) · July 1, 2020 A 2-yr-old patient with a giant craniopharyngioma presented with seizures and panhypopituitarism. The lesion was initially approached at an outside institution with a transfrontal cyst fenestration, but progressive growth occurred later. Multiple managemen ... Full text Link to item Cite

Medically-refractory epilepsy

Chapter · June 16, 2020 Epilepsy is a common and debilitating neurological disorder that afflicts over 3 million people in the United States alone and up to 1% of the global population. Various forms of seizure disorders are primarily first medically managed with anti-epileptic d ... Cite

Randomized Controlled Trials in Functional Neurosurgery-Association of Device Approval Status and Trial Quality.

Journal Article Neuromodulation · June 2020 INTRODUCTION: Randomized controlled trials (RCTs) have been critical in evaluating the safety and efficacy of functional neurosurgery interventions. Given this, we sought to systematically assess the quality of functional neurosurgery RCTs. METHODS: We use ... Full text Link to item Cite

Anatomic and Thermometric Analysis of Cranial Nerve Palsy after Laser Amygdalohippocampotomy for Mesial Temporal Lobe Epilepsy.

Journal Article Oper Neurosurg (Hagerstown) · June 1, 2020 BACKGROUND: Laser interstitial thermal therapy (LITT) is a minimally invasive therapy for treating medication-resistant mesial temporal lobe epilepsy. Cranial nerve (CN) palsy has been reported as a procedural complication, but the mechanism of this compli ... Full text Link to item Cite

Factors associated with syrinx size in pediatric patients treated for Chiari malformation type I and syringomyelia: a study from the Park-Reeves Syringomyelia Research Consortium.

Journal Article J Neurosurg Pediatr · June 1, 2020 OBJECTIVE: Factors associated with syrinx size in pediatric patients undergoing posterior fossa decompression (PFD) or PFD with duraplasty (PFDD) for Chiari malformation type I (CM-I) with syringomyelia (SM; CM-I+SM) are not well established. METHODS: Usin ... Full text Link to item Cite

Transcriptional analyses of adult and pediatric adamantinomatous craniopharyngioma reveals similar expression signatures regarding potential therapeutic targets.

Journal Article Acta Neuropathol Commun · May 13, 2020 Adamantinomatous craniopharyngioma (ACP) is a biologically benign but clinically aggressive lesion that has a significant impact on quality of life. The incidence of the disease has a bimodal distribution, with peaks occurring in children and older adults. ... Full text Open Access Link to item Cite

Patterns of Care and Age-Specific Impact of Extent of Resection and Adjuvant Radiotherapy in Pediatric Pineoblastoma.

Journal Article Neurosurgery · May 1, 2020 BACKGROUND: Pediatric pineoblastomas are highly aggressive tumors that portend poor outcomes despite multimodal management. Controversy remains regarding optimal disease management. OBJECTIVE: To evaluate patterns of care and optimal clinical management of ... Full text Link to item Cite

Multi-Directional Dynamic Model for Traumatic Brain Injury Detection.

Journal Article J Neurotrauma · April 1, 2020 Given the worldwide adverse impact of traumatic brain injury (TBI) on the human population, its diagnosis and prediction are of utmost importance. Historically, many studies have focused on associating head kinematics to brain injury risk. Recently, there ... Full text Link to item Cite

Early Diffusion Magnetic Resonance Imaging Changes in Normal-Appearing Brain in Pediatric Moyamoya Disease.

Journal Article Neurosurgery · April 1, 2020 BACKGROUND: Moyamoya disease often leads to ischemic strokes visible on diffusion-weighted imaging (DWI) and T2-weighted magnetic resonance imaging (MRI) with subsequent cognitive impairment. In adults with moyamoya, apparent diffusion coefficient (ADC) is ... Full text Link to item Cite

Evaluating Shunt Survival Following Ventriculoperitoneal Shunting with and without Stereotactic Navigation in Previously Shunt-Naïve Patients.

Journal Article World Neurosurg · April 2020 BACKGROUND: Ventriculoperitoneal shunts are used to alleviate elevated intracranial pressure due to either hydrocephalus or idiopathic intracranial hypertension; however, shunt failure is a significant neurosurgical problem. Despite increases in intraopera ... Full text Link to item Cite

Endoscopic endonasal surgery for giant pediatric craniopharyngioma

Journal Article Neurosurgical Focus: Video · April 1, 2020 Pediatric craniopharyngiomas that were once thought to be inoperable or considered only for salvage medical therapy are now being reconsidered for aggressive surgical resection via endoscopic endonasal approaches. Here we review the operative video case of ... Full text Cite

Boda Bodas and Road Traffic Injuries in Uganda: An Overview of Traffic Safety Trends from 2009 to 2017.

Journal Article Int J Environ Res Public Health · March 22, 2020 INTRODUCTION: Road traffic injuries (RTIs) are an important contributor to the morbidity and mortality of developing countries. In Uganda, motorcycle taxis, known as boda bodas, are responsible for a growing proportion of RTIs. This study seeks to evaluate ... Full text Open Access Link to item Cite

An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci.

Journal Article Clin Epigenetics · March 14, 2020 BACKGROUND: Previous studies using candidate gene and genome-wide approaches have identified epigenetic changes in DNA methylation (DNAm) associated with posttraumatic stress disorder (PTSD). METHODS: In this study, we performed an EWAS of PTSD in a cohort ... Full text Open Access Link to item Cite

Postoperative outcomes following pediatric intracranial electrode monitoring: A case for stereoelectroencephalography (SEEG).

Journal Article Epilepsy Behav · March 2020 BACKGROUND: For patients with medically refractory epilepsy, intracranial electrode monitoring can help identify epileptogenic foci. Despite the increasing utilization of stereoelectroencephalography (SEEG), the relative risks or benefits associated with t ... Full text Link to item Cite

Molecular correlates of cerebellar mutism syndrome in medulloblastoma.

Journal Article Neuro Oncol · February 20, 2020 BACKGROUND: Cerebellar mutism syndrome (CMS) is a common complication following resection of posterior fossa tumors, most commonly after surgery for medulloblastoma. Medulloblastoma subgroups have historically been treated as a single entity when assessing ... Full text Link to item Cite

Cortical stimulation mapping for localization of visual and auditory language in pediatric epilepsy patients.

Journal Article J Neurosurg Pediatr · February 1, 2020 OBJECTIVE: To determine resection margins near eloquent tissue, electrical cortical stimulation (ECS) mapping is often used with visual naming tasks. In recent years, auditory naming tasks have been found to provide a more comprehensive map. Differences in ... Full text Open Access Link to item Cite

Neurocognitive markers of childhood abuse in individuals with PTSD: Findings from the INTRuST Clinical Consortium.

Journal Article J Psychiatr Res · February 2020 To date, few studies have evaluated the contribution of early life experiences to neurocognitive abnormalities observed in posttraumatic stress disorder (PTSD). Childhood maltreatment is common among individuals with PTSD and is thought to catalyze stress- ... Full text Link to item Cite

Dynamic Blood-Brain Barrier Regulation in Mild Traumatic Brain Injury.

Journal Article J Neurotrauma · January 15, 2020 Whereas the diagnosis of moderate and severe traumatic brain injury (TBI) is readily visible on current medical imaging paradigms (magnetic resonance imaging [MRI] and computed tomography [CT] scanning), a far greater challenge is associated with the diagn ... Full text Link to item Cite

Outcomes in children undergoing posterior fossa decompression and duraplasty with and without tonsillar reduction for Chiari malformation type I and syringomyelia: a pilot prospective multicenter cohort study.

Journal Article J Neurosurg Pediatr · January 1, 2020 OBJECTIVE: Despite significant advances in diagnostic and surgical techniques, the surgical management of Chiari malformation type I (CM-I) with associated syringomyelia remains controversial, and the type of surgery performed is surgeon dependent. This st ... Full text Link to item Cite

Utilization of Novel High-Resolution, MRI-Based Vascular Imaging Modality for Preoperative Stereoelectroencephalography Planning in Children: A Technical Note.

Journal Article Stereotact Funct Neurosurg · 2020 INTRODUCTION: Stereoelectroencephalography (SEEG) is a powerful intracranial diagnostic tool that requires accurate imaging for proper electrode trajectory planning to ensure efficacy and maximize patient safety. Computed tomography (CT) angiography and di ... Full text Link to item Cite

Robot-assisted versus manual navigated stereoelectroencephalography in adult medically-refractory epilepsy patients.

Journal Article Epilepsy Res · January 2020 OBJECTIVE: Stereoelectroencephalography (SEEG) has experienced a recent growth in adoption for epileptogenic zone (EZ) localization. Advances in robotics have the potential to improve the efficiency and safety of this intracranial seizure monitoring method ... Full text Link to item Cite

Diffusion tensor magnetic resonance imaging of the optic nerves in pediatric hydrocephalus.

Journal Article Neurosurg Focus · December 1, 2019 OBJECTIVE: While conventional imaging can readily identify ventricular enlargement in hydrocephalus, structural changes that underlie microscopic tissue injury might be more difficult to capture. MRI-based diffusion tensor imaging (DTI) uses properties of ... Full text Link to item Cite

Radiological and clinical predictors of scoliosis in patients with Chiari malformation type I and spinal cord syrinx from the Park-Reeves Syringomyelia Research Consortium.

Journal Article J Neurosurg Pediatr · November 1, 2019 OBJECTIVE: Scoliosis is frequently a presenting sign of Chiari malformation type I (CM-I) with syrinx. The authors' goal was to define scoliosis in this population and describe how radiological characteristics of CM-I and syrinx relate to the presence and ... Full text Link to item Cite

The authors reply.

Journal Article Pediatr Crit Care Med · November 2019 Full text Link to item Cite

Massive clonal expansion of medulloblastoma-specific T cells during adoptive cellular therapy.

Journal Article Sci Adv · November 2019 In both human and murine systems, we have developed an adoptive cellular therapy platform against medulloblastoma and glioblastoma that uses dendritic cells pulsed with a tumor RNA transcriptome to expand polyclonal tumor-reactive T cells against a plurali ... Full text Open Access Link to item Cite

Risks, costs, and outcomes of cerebrospinal fluid leaks after pediatric skull fractures: a MarketScan analysis between 2007 and 2015.

Journal Article Neurosurg Focus · November 1, 2019 OBJECTIVE: Skull fractures are common after blunt pediatric head trauma. CSF leaks are a rare but serious complication of skull fractures; however, little evidence exists on the risk of developing a CSF leak following skull fracture in the pediatric popula ... Full text Link to item Cite

Topical Vancomycin for Surgical Prophylaxis in Pediatric Craniofacial Surgeries.

Journal Article J Craniofac Surg · October 2019 Topical vancomycin has been demonstrated to be safe and effective for reducing surgical site infections (SSIs) following spine surgery in both adults and children, however, there are no studies of its efficacy in reducing SSIs in craniofacial surgery. The ... Full text Link to item Cite

Arterial spin labeling perfusion changes of the frontal lobes in children with posterior fossa syndrome.

Journal Article J Neurosurg Pediatr · October 1, 2019 OBJECTIVE: Posterior fossa syndrome (PFS) is a common complication following the resection of posterior fossa tumors in children. The pathophysiology of PFS remains incompletely elucidated; however, the wide-ranging symptoms of PFS suggest the possibility ... Full text Link to item Cite

Ferumoxytol-enhanced MRI for surveillance of pediatric cerebral arteriovenous malformations.

Journal Article J Neurosurg Pediatr · October 1, 2019 OBJECTIVE: Children with intracranial arteriovenous malformations (AVMs) undergo digital DSA for lesion surveillance following their initial diagnosis. However, DSA carries risks of radiation exposure, particularly for the growing pediatric brain and over ... Full text Link to item Cite

Posterior fossa syndrome and increased mean diffusivity in the olivary bodies.

Journal Article J Neurosurg Pediatr · October 1, 2019 OBJECTIVE: Posterior fossa syndrome (PFS) is a common postoperative complication following resection of posterior fossa tumors in children. It typically presents 1 to 2 days after surgery with mutism, ataxia, emotional lability, and other behavioral sympto ... Full text Link to item Cite

Stereotactic laser ablation for completion corpus callosotomy.

Journal Article J Neurosurg Pediatr · October 1, 2019 OBJECTIVE: Completion corpus callosotomy can offer further remission from disabling seizures when a prior partial corpus callosotomy has failed and residual callosal tissue is identified on imaging. Traditional microsurgical approaches to section residual ... Full text Link to item Cite

Longitudinal Changes in Hippocampal Subfield Volume Associated with Collegiate Football.

Journal Article J Neurotrauma · October 1, 2019 Collegiate football athletes are subject to repeated traumatic brain injuriesthat may cause brain injury. The hippocampus is composed of several distinct subfields with possible differential susceptibility to injury. The aim of this study is to determine w ... Full text Link to item Cite

Targeted genomic CRISPR-Cas9 screen identifies MAP4K4 as essential for glioblastoma invasion.

Journal Article Sci Rep · September 30, 2019 Among high-grade brain tumors, glioblastoma is particularly difficult to treat, in part due to its highly infiltrative nature which contributes to the malignant phenotype and high mortality in patients. In order to better understand the signaling pathways ... Full text Open Access Link to item Cite

Central Nervous System Tumors in Uganda: Outcomes of Surgical Treatment and Complications Assessed Through Telephone Survey.

Journal Article World Neurosurg · September 2019 BACKGROUND: Uganda has one of the largest unmet neurosurgical needs in the world, but has seen major improvements in neurosurgery-largely centered at Mulago National Referral Hospital (MNRH). This study implements the first long-term follow-up and outcomes ... Full text Link to item Cite

Transnasal endoscopic approach for pediatric skull base lesions: a case series.

Journal Article J Neurosurg Pediatr · September 1, 2019 OBJECTIVE: Transnasal endoscopic transsphenoidal approaches constitute an essential technique for the resection of skull base tumors in adults. However, in the pediatric population, sellar and suprasellar lesions have historically been treated by craniotom ... Full text Link to item Cite

Stability of Blood Biomarkers of Traumatic Brain Injury.

Journal Article J Neurotrauma · August 15, 2019 Blood biomarker tests were recently approved for clinical diagnosis of traumatic brain injury (TBI), yet there are still fundamental questions that need attention. One such question is the stability of putative biomarkers in blood over the course of severa ... Full text Link to item Cite

Spatiotemporal Tracking of Brain-Tumor-Associated Myeloid Cells in Vivo through Optical Coherence Tomography with Plasmonic Labeling and Speckle Modulation.

Journal Article ACS Nano · July 23, 2019 By their nature, tumors pose a set of profound challenges to the immune system with respect to cellular recognition and response coordination. Recent research indicates that leukocyte subpopulations, especially tumor-associated macrophages (TAMs), can exer ... Full text Link to item Cite

Speckle modulation enables high-resolution wide-field human brain tumor margin detection and in vivo murine neuroimaging.

Journal Article Sci Rep · July 17, 2019 Current in vivo neuroimaging techniques provide limited field of view or spatial resolution and often require exogenous contrast. These limitations prohibit detailed structural imaging across wide fields of view and hinder intraoperative tumor margin detec ... Full text Open Access Link to item Cite

Intravenous and Intravascular Drug Delivery

Chapter · June 25, 2019 The blood-brain barrier (BBB) is a unique entity within the central nervous system (CNS) that consists of both passive and active mechanisms to regulate access to the brain. This structure maintains the ionic and volumetric environments of the brain, and s ... Full text Cite

Guidelines for the Management of Pediatric Severe Traumatic Brain Injury, Third Edition: Update of the Brain Trauma Foundation Guidelines, Executive Summary.

Journal Article Neurosurgery · June 1, 2019 The purpose of this work is to identify and synthesize research produced since the second edition of these Guidelines was published and incorporate new results into revised evidence-based recommendations for the treatment of severe traumatic brain injury i ... Full text Link to item Cite

Lateral impacts correlate with falx cerebri displacement and corpus callosum trauma in sports-related concussions.

Journal Article Biomech Model Mechanobiol · June 2019 Corpus callosum trauma has long been implicated in mild traumatic brain injury (mTBI), yet the mechanism by which forces penetrate this structure is unknown. We investigated the hypothesis that coronal and horizontal rotations produce motion of the falx ce ... Full text Link to item Cite

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Journal Article Neurosurgery · May 1, 2019 Full text Cite

Mimicking brain tumor-vasculature microanatomical architecture via co-culture of brain tumor and endothelial cells in 3D hydrogels.

Journal Article Biomaterials · May 2019 Glioblastoma (GBM) is an aggressive malignant brain tumor with median survival of 12 months and 5-year survival rate less than 5%. GBM is highly vascularized, and the interactions between tumor and endothelial cells play an important role in driving tumor ... Full text Link to item Cite

Guidelines for the Management of Pediatric Severe Traumatic Brain Injury, Third Edition: Update of the Brain Trauma Foundation Guidelines, Executive Summary.

Journal Article Pediatr Crit Care Med · March 2019 OBJECTIVES: The purpose of this work is to identify and synthesize research produced since the second edition of these Guidelines was published and incorporate new results into revised evidence-based recommendations for the treatment of severe traumatic br ... Full text Link to item Cite

Management of Pediatric Severe Traumatic Brain Injury: 2019 Consensus and Guidelines-Based Algorithm for First and Second Tier Therapies.

Journal Article Pediatr Crit Care Med · March 2019 OBJECTIVES: To produce a treatment algorithm for the ICU management of infants, children, and adolescents with severe traumatic brain injury. DATA SOURCES: Studies included in the 2019 Guidelines for the Management of Pediatric Severe Traumatic Brain Injur ... Full text Link to item Cite

Image Guidance for Ventricular Shunt Surgery: An Analysis of Ventricular Size and Proximal Revision Rates.

Journal Article Neurosurgery · March 1, 2019 BACKGROUND: Image guidance is a promising technology that could lead to lower rates of premature shunt failure by decreasing the rate of inaccurate proximal catheter placement. OBJECTIVE: To perform a detailed radiographic analysis of ventricular size usin ... Full text Link to item Cite

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Journal Article Clinical Neurosurgery · March 1, 2019 Full text Cite

Associations between neuropsychiatric and health status outcomes in individuals with probable mTBI.

Journal Article Psychiatry Res · February 2019 Mild traumatic brain injury (mTBI) is a common occurrence, and may impact distal outcomes in a subgroup of individuals. Improved characterization of health outcomes and identification of factors associated with poor outcomes is needed to better understand ... Full text Link to item Cite

A Review of Magnetic Particle Imaging and Perspectives on Neuroimaging.

Journal Article AJNR Am J Neuroradiol · February 2019 Magnetic particle imaging is an emerging tomographic technique with the potential for simultaneous high-resolution, high-sensitivity, and real-time imaging. Magnetic particle imaging is based on the unique behavior of superparamagnetic iron oxide nanoparti ... Full text Link to item Cite

Long-Term Supratentorial Radiologic Effects of Surgery and Local Radiation in Children with Infratentorial Ependymoma.

Journal Article World Neurosurg · February 2019 BACKGROUND: Current standard of care for children with infratentorial ependymoma includes maximal safe resection and local radiation of 54-59 Gray. High-dose local radiation has been associated with declines in multiple cognitive domains. The anatomic and ... Full text Link to item Cite

Microglia are effector cells of CD47-SIRPα antiphagocytic axis disruption against glioblastoma.

Journal Article Proc Natl Acad Sci U S A · January 15, 2019 Glioblastoma multiforme (GBM) is a highly aggressive malignant brain tumor with fatal outcome. Tumor-associated macrophages and microglia (TAMs) have been found to be major tumor-promoting immune cells in the tumor microenvironment. Hence, modulation and r ... Full text Open Access Link to item Cite

Temporal Delays Along the Neurosurgical Care Continuum for Traumatic Brain Injury Patients at a Tertiary Care Hospital in Kampala, Uganda.

Journal Article Neurosurgery · January 1, 2019 BACKGROUND: Significant care continuum delays between acute traumatic brain injury (TBI) and definitive surgery are associated with poor outcomes. Use of the "3 delays" model to evaluate TBI outcomes in low- and middle-income countries has not been perform ... Full text Open Access Link to item Cite

Long-term follow-up of pediatric head trauma patients treated at Mulago National Referral Hospital in Uganda.

Journal Article J Neurosurg Pediatr · January 1, 2019 In Brief: This study used telephone surveys as a novel method of measuring health outcomes and tracking healthcare utilization in pediatric head trauma patients at the national referral hospital in Uganda. As the first-ever long-term follow-up of this pati ... Full text Link to item Cite

MR Imaging-Based Radiomic Signatures of Distinct Molecular Subgroups of Medulloblastoma.

Journal Article AJNR Am J Neuroradiol · January 2019 BACKGROUND AND PURPOSE: Distinct molecular subgroups of pediatric medulloblastoma confer important differences in prognosis and therapy. Currently, tissue sampling is the only method to obtain information for classification. Our goal was to develop and val ... Full text Link to item Cite

A novel mesial temporal stereotactic coordinate system.

Journal Article J Neurosurg · January 1, 2019 OBJECTIVE Stereotactic laser ablation and neurostimulator placement represent an evolution in staged surgical intervention for epilepsy. As this practice evolves, optimal targeting will require standardized outcome measures that compare electrode lead or l ... Full text Link to item Cite

Brain abscess caused by Trueperella bernardiae in a child

Journal Article Surgical Neurology International · January 1, 2019 Background: Recurrent intracranial abscesses secondary to refractory otitis media present a challenge which demands multidisciplinary collaboration. Case Description: We present the first known case of pediatric brain abscess caused by a polymicrobial infe ... Full text Cite

Characteristics and Long-Term Outcome of 127 Children With Cerebral Arteriovenous Malformations.

Journal Article Neurosurgery · January 1, 2019 BACKGROUND: Population-based long-term data on pediatric patients with cerebral arteriovenous malformations (AVMs) are limited. OBJECTIVE: To clarify the characteristics and long-term outcome of pediatric patients with AVM. METHODS: A retrospective analysi ... Full text Link to item Cite

Topical vancomycin for surgical prophylaxis in non-instrumented pediatric spinal surgeries.

Journal Article Childs Nerv Syst · January 2019 STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To determine if topical vancomycin irrigation reduces the incidence of post-operative surgical site infections following pediatric spinal procedures. Surgical site infections (SSIs) following spinal proc ... Full text Link to item Cite

Comments

Journal Article Clinical Neurosurgery · December 1, 2018 Cite

Development of best practices to minimize wound complications after complex tethered spinal cord surgery: a modified Delphi study.

Journal Article J Neurosurg Pediatr · December 1, 2018 OBJECTIVEComplications after complex tethered spinal cord (cTSC) surgery include infections and cerebrospinal fluid (CSF) leaks. With little empirical evidence to guide management, there is variability in the interventions undertaken to limit complications ... Full text Link to item Cite

Topical vancomycin surgical prophylaxis in pediatric open craniotomies: an institutional experience.

Journal Article J Neurosurg Pediatr · December 1, 2018 OBJECTIVETopical antimicrobial compounds are safe and can reduce cost and complications associated with surgical site infections (SSIs). Topical vancomycin has been an effective tool for reducing SSIs following routine neurosurgical procedures in the spine ... Full text Link to item Cite

Minimally invasive approaches to craniosynostosis.

Journal Article J Neurosurg Sci · December 2018 Craniosynostosis (CS) is defined as the premature fusion of one or more calvarial sutures. This carries several consequences, including abnormal/asymmetric cranial vault development, increased intracranial pressure, compromised neurocognitive development, ... Full text Link to item Cite

Laser interstitial thermal therapy (LITT): Seizure outcomes for refractory mesial temporal lobe epilepsy.

Journal Article Epilepsy Behav · December 2018 BACKGROUND: Laser interstitial thermal therapy (LITT) is a minimally invasive alternative with less cognitive risks compared with traditional surgery for focal drug-resistant epilepsy. OBJECTIVE: We describe seizure outcomes and complications after LITT in ... Full text Link to item Cite

Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia.

Journal Article Mol Psychiatry · November 2018 Schizophrenia is a neurodevelopmental disorder that affects up to 1% of the general population. Various genes show associations with schizophrenia and a very weak nominal association with the tight junction protein, claudin-5, has previously been identifie ... Full text Open Access Link to item Cite

Robot-guided pediatric stereoelectroencephalography: single-institution experience.

Journal Article J Neurosurg Pediatr · November 1, 2018 OBJECTIVEStereoelectroencephalography (SEEG) has increased in popularity for localization of epileptogenic zones in drug-resistant epilepsy because safety, accuracy, and efficacy have been well established in both adult and pediatric populations. Developme ... Full text Link to item Cite

Neural tube defects in Uganda: follow-up outcomes from a national referral hospital.

Journal Article Neurosurg Focus · October 2018 OBJECTIVE: Children with neural tube defects (NTDs) require timely surgical intervention coupled with long-term management by multiple highly trained specialty healthcare teams. In resource-limited settings, outcomes are greatly affected by the lack of coo ... Full text Link to item Cite

Surgical outcomes of pediatric spinal cord astrocytomas: systematic review and meta-analysis.

Journal Article J Neurosurg Pediatr · October 2018 OBJECTIVE: Pediatric spinal astrocytomas are rare spinal lesions that pose unique management challenges. Therapeutic options include gross-total resection (GTR), subtotal resection (STR), and adjuvant chemotherapy or radiation therapy. With no randomized c ... Full text Link to item Cite

Common Conditions Requiring Long-Term Anticoagulation in Neurosurgical Patients.

Journal Article Neurosurg Clin N Am · October 2018 Long-term anticoagulant therapy prevents thrombosis. Management of neurosurgical patients with conditions such as atrial fibrillation, mechanical heart valves, and other prothrombotic states necessitates application of a strategy to mitigate hemorrhagic co ... Full text Link to item Cite

Complications following pediatric cranioplasty after decompressive craniectomy: a multicenter retrospective study.

Journal Article J Neurosurg Pediatr · September 2018 OBJECTIVE In children, the repair of skull defects arising from decompressive craniectomy presents a unique set of challenges. Single-center studies have identified different risk factors for the common complications of cranioplasty resorption and infectio ... Full text Link to item Cite

Stereoelectroencephalography in children: a review.

Journal Article Neurosurg Focus · September 2018 Stereoelectroencephalography (SEEG) is an intracranial diagnostic measure that has grown in popularity in the United States as outcomes data have demonstrated its benefits and safety. The main uses of SEEG include 1) exploration of deep cortical/sulcal str ... Full text Link to item Cite

High-resolution 3D volumetric contrast-enhanced MR angiography with a blood pool agent (ferumoxytol) for diagnostic evaluation of pediatric brain arteriovenous malformations.

Conference J Neurosurg Pediatr · September 2018 OBJECTIVE Patients with brain arteriovenous malformations (AVMs) often require repeat imaging with MRI or MR angiography (MRA), CT angiography (CTA), and digital subtraction angiography (DSA). The ideal imaging modality provides excellent vascular visualiz ... Full text Link to item Cite

Rapid-sequence brain magnetic resonance imaging for Chiari I abnormality.

Journal Article J Neurosurg Pediatr · August 2018 OBJECTIVE Fast magnetic resonance imaging (fsMRI) sequences are single-shot spin echo images with fast acquisition times that have replaced CT scans for many conditions. Introduced as a means of evaluating children with hydrocephalus and macrocephaly, thes ... Full text Link to item Cite

Safety of Dynamic Magnetic Resonance Imaging of the Cervical Spine in Children Performed without Neurosurgical Supervision.

Journal Article World Neurosurg · August 2018 OBJECTIVE: The need for neurosurgical supervision as well as the general safety and utility of dynamic magnetic resonance imaging (MRI) of the cervical spine in children remains controversial. We present the largest descriptive cohort study of cervical fle ... Full text Link to item Cite

First-in-human intraoperative near-infrared fluorescence imaging of glioblastoma using cetuximab-IRDye800.

Journal Article J Neurooncol · August 2018 INTRODUCTION: Maximizing extent of surgical resection with the least morbidity remains critical for survival in glioblastoma patients, and we hypothesize that it can be improved by enhancements in intraoperative tumor detection. In a clinical study, we det ... Full text Open Access Link to item Cite

A Combination of Ontogeny and CNS Environment Establishes Microglial Identity.

Journal Article Neuron · June 27, 2018 Microglia, the brain's resident macrophages, are dynamic CNS custodians with surprising origins in the extra-embryonic yolk sac. The consequences of their distinct ontogeny are unknown but critical to understanding and treating brain diseases. We created a ... Full text Link to item Cite

White matter abnormalities in mild traumatic brain injury with and without post-traumatic stress disorder: a subject-specific diffusion tensor imaging study.

Journal Article Brain Imaging Behav · June 2018 Mild traumatic brain injuries (mTBIs) are often associated with posttraumatic stress disorder (PTSD). In cases of chronic mTBI, accurate diagnosis can be challenging due to the overlapping symptoms this condition shares with PTSD. Furthermore, mTBIs are he ... Full text Link to item Cite

Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy.

Journal Article Ann Neurol · June 2018 OBJECTIVE: Somatic variants are a recognized cause of epilepsy-associated focal malformations of cortical development (MCD). We hypothesized that somatic variants may underlie a wider range of focal epilepsy, including nonlesional focal epilepsy (NLFE). Th ... Full text Link to item Cite

Life After the Neurosurgical Ward in Sub-Saharan Africa: Neurosurgical Treatment and Outpatient Outcomes in Uganda.

Journal Article World Neurosurg · May 2018 BACKGROUND: In the past decade, neurosurgery in Uganda experienced increasing surgical volume and a new residency training program. Although research has examined surgical capacity, minimal data exist on the patient population treated by neurosurgery and t ... Full text Link to item Cite

Neurosurgical Randomized Controlled Trials-Distance Travelled.

Journal Article Neurosurgery · May 1, 2018 BACKGROUND: The evidence base for many neurosurgical procedures has been limited. We performed a comprehensive and systematic analysis of study design, quality of reporting, and trial results of neurosurgical randomized controlled trials (RCTs). OBJECTIVE: ... Full text Link to item Cite

Improved operative efficiency using a real-time MRI-guided stereotactic platform for laser amygdalohippocampotomy.

Journal Article J Neurosurg · April 2018 OBJECTIVE MR-guided laser interstitial thermal therapy (MRgLITT) is a minimally invasive method for thermal destruction of benign or malignant tissue that has been used for selective amygdalohippocampal ablation for the treatment of temporal lobe epilepsy. ... Full text Link to item Cite

Diagnostic Utility of Intraoperative Neurophysiological Monitoring for Intramedullary Spinal Cord Tumors: Systematic Review and Meta-Analysis.

Journal Article Clin Spine Surg · April 2018 STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVE: The aim of this study was to systematically evaluate the diagnostic utility of intraoperative neurophysiological monitoring (IONM) for detecting postoperative injury in resection of intramedulla ... Full text Link to item Cite

Multi-site harmonization of diffusion MRI data in a registration framework.

Journal Article Brain Imaging Behav · February 2018 Diffusion MRI (dMRI) data acquired on different scanners varies significantly in its content throughout the brain even if the acquisition parameters are nearly identical. Thus, proper harmonization of such data sets is necessary to increase the sample size ... Full text Link to item Cite

Occipital Dermal Sinus Tract.

Journal Article J Pediatr · February 2018 Full text Link to item Cite

Visual hallucinations: A novel complication after hemispherectomy.

Journal Article Epilepsy Behav Case Rep · 2018 Two patients at our center experienced florid visual hallucinations following hemispherectomy. The first patient had drug-resistant left hemispheric focal seizures at 20 months of age from a previous stroke. Following functional hemispherectomy at age 3, h ... Full text Open Access Link to item Cite

Deep brain stimulation for pediatric neuropsychiatric disorders

Chapter · January 1, 2018 Deep brain stimulation (DBS) is a well-established treatment for medically refractory movement disorders in adults such as Parkinson’s disease, tremor, and dystonia and is currently under investigation for treatment of neuropsychiatric disorders such as de ... Full text Cite

Virtual surgical planning decreases operative time for isolated single suture and multi-suture craniosynostosis repair

Journal Article Plastic and Reconstructive Surgery - Global Open · January 1, 2018 Background: Cranial vault reconstruction is a complex procedure due to the need for precise 3-dimensional outcomes. Traditionally, the process involves manual bending of calvarial bone and plates. With the advent of virtual surgical planning (VSP), this pr ... Full text Cite

Quality of Care and Outcomes in Pediatric Neurosurgery: Incorporating Evidence-Based Practice

Chapter · January 1, 2018 Pediatric neurosurgical conditions can dramatically affect development, functional status, and therefore quality of life—these changes can have life lasting consequences or benefits. There are very few disease-specific quality outcome scales, which have be ... Full text Cite

Long-term outcomes of primarily metastatic juvenile pilocytic astrocytoma in children.

Journal Article J Neurosurg Pediatr · January 2018 OBJECTIVE Primarily metastatic juvenile pilocytic astrocytoma (JPA) is rare, likely representing 2%-3% of all cases of JPA. Due to the rarity of primarily metastatic JPA, there is currently no standard treatment paradigm and the long-term outcomes are not ... Full text Link to item Cite

Regulatory T cell subsets in patients with medulloblastoma at diagnosis and during standard irradiation and chemotherapy (PBTC N-11).

Journal Article Cancer Immunol Immunother · December 2017 BACKGROUND: We evaluated circulating levels of immunosuppressive regulatory T cells (Tregs) and other lymphocyte subsets in patients with newly diagnosed medulloblastoma (MBL) undergoing surgery compared to a control cohort of patients undergo craniectomy ... Full text Link to item Cite

Fractal structure in the volumetric contrast enhancement of malignant gliomas as a marker of oxidative metabolic pathway gene expression

Journal Article Translational Cancer Research · December 1, 2017 Background: Fractal structure is found throughout many processes in nature, and often arises from sets of simple rules. We examined MRI contrast enhancement patterns from glioblastoma patients for evidence of fractal structure and correlated these with gen ... Full text Cite

Brain Oxygen Optimization in Severe Traumatic Brain Injury Phase-II: A Phase II Randomized Trial.

Journal Article Crit Care Med · November 2017 OBJECTIVES: A relationship between reduced brain tissue oxygenation and poor outcome following severe traumatic brain injury has been reported in observational studies. We designed a Phase II trial to assess whether a neurocritical care management protocol ... Full text Link to item Cite

Somatic uniparental disomy of Chromosome 16p in hemimegalencephaly.

Journal Article Cold Spring Harb Mol Case Stud · September 2017 Hemimegalencephaly (HME) is a heterogeneous cortical malformation characterized by enlargement of one cerebral hemisphere. Somatic variants in mammalian target of rapamycin (mTOR) regulatory genes have been implicated in some HME cases; however, ∼70% have ... Full text Open Access Link to item Cite

Comments

Journal Article Neurosurgery · September 1, 2017 Full text Cite

Molecular Analyses Reveal Inflammatory Mediators in the Solid Component and Cyst Fluid of Human Adamantinomatous Craniopharyngioma.

Journal Article J Neuropathol Exp Neurol · September 1, 2017 Pediatric adamantinomatous craniopharyngioma (ACP) is a highly solid and cystic tumor, often causing substantial damage to critical neuroendocrine structures such as the hypothalamus, pituitary gland, and optic apparatus. Paracrine signaling mechanisms dri ... Full text Link to item Cite

Prolonged Blood-Brain Barrier Disruption Following Laser Interstitial Ablation in Epilepsy: A Case Series with a Case Report of Postablation Optic Neuritis.

Journal Article World Neurosurg · August 2017 OBJECTIVE: Laser interstitial thermal therapy has become increasingly popular for targeting epileptic foci in a minimally invasive fashion. Despite its use in >1000 patients, the long-term effects of photothermal injury on brain physiology remain poorly un ... Full text Link to item Cite

Reply: Comments

Journal Article Neurosurgery · July 1, 2017 Full text Cite

Brain Perfusion and Diffusion Abnormalities in Children Treated for Posterior Fossa Brain Tumors.

Journal Article J Pediatr · June 2017 OBJECTIVE: To compare cerebral perfusion and diffusion in survivors of childhood posterior fossa brain tumor with neurologically normal controls and correlate differences with cognitive dysfunction. STUDY DESIGN: We analyzed retrospectively arterial spin-l ... Full text Link to item Cite

Modeling and Optimization of Airbag Helmets for Preventing Head Injuries in Bicycling.

Journal Article Ann Biomed Eng · April 2017 Bicycling is the leading cause of sports-related traumatic brain injury. Most of the current bike helmets are made of expanded polystyrene (EPS) foam and ultimately designed to prevent blunt trauma, e.g., skull fracture. However, these helmets have limited ... Full text Link to item Cite

Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors.

Journal Article Sci Transl Med · March 15, 2017 Morbidity and mortality associated with pediatric malignant primary brain tumors remain high in the absence of effective therapies. Macrophage-mediated phagocytosis of tumor cells via blockade of the anti-phagocytic CD47-SIRPα interaction using anti-CD47 a ... Full text Link to item Cite

The clinical and financial impact of a pediatric surgical neuro-oncology clinical trial.

Journal Article J Neurooncol · March 2017 Pediatric surgical trials are rare and the impact of such trials on the institutions in which they are conducted is unknown. The purpose of this study was to analyze the clinical and financial impact of The Re-MATCH trial, a Phase I clinical trial requirin ... Full text Link to item Cite

Perioperative outcomes for pediatric neurosurgical procedures: analysis of the National Surgical Quality Improvement Program-Pediatrics.

Journal Article J Neurosurg Pediatr · March 2017 OBJECTIVE Existing studies have shown a high overall rate of adverse events (AEs) following pediatric neurosurgical procedures. However, little is known regarding the morbidity of specific procedures or the association with risk factors to help guide quali ... Full text Link to item Cite

R-SCAN: Imaging for Pediatric Minor Head Trauma.

Journal Article J Am Coll Radiol · February 2017 Full text Link to item Cite

Telephone Problem Solving for Service Members with Mild Traumatic Brain Injury: A Randomized, Clinical Trial.

Journal Article J Neurotrauma · January 15, 2017 Mild traumatic brain injury (mTBI) is a common injury for service members in recent military conflicts. There is insufficient evidence of how best to treat the consequences of mTBI. In a randomized, clinical trial, we evaluated the efficacy of telephone-de ... Full text Link to item Cite

A prospective neurosurgical registry evaluating the clinical care of traumatic brain injury patients presenting to Mulago National Referral Hospital in Uganda.

Journal Article PLoS One · 2017 BACKGROUND: Traumatic Brain Injury (TBI) is disproportionally concentrated in low- and middle-income countries (LMICs), with the odds of dying from TBI in Uganda more than 4 times higher than in high income countries (HICs). The objectives of this study ar ... Full text Open Access Link to item Cite

Nanoparticle engineered TRAIL-overexpressing adipose-derived stem cells target and eradicate glioblastoma via intracranial delivery.

Journal Article Proc Natl Acad Sci U S A · November 29, 2016 Glioblastoma multiforme (GBM) is one of the most intractable of human cancers, principally because of the highly infiltrative nature of these neoplasms. Tracking and eradicating infiltrating GBM cells and tumor microsatellites is of utmost importance for t ... Full text Link to item Cite

Diagnosis and treatment of pediatric frontotemporal pits: report of 2 cases.

Journal Article J Neurosurg Pediatr · October 2016 In contrast to more common nasal and cervical lesions, the frontotemporal pit is a rarely encountered lesion that is often associated with a dermoid and may track intracranially. Due to delays in diagnosis, the propensity to spread intracranially, and the ... Full text Link to item Cite

Integrin-Targeting Knottin Peptide-Drug Conjugates Are Potent Inhibitors of Tumor Cell Proliferation.

Journal Article Angew Chem Int Ed Engl · August 16, 2016 Antibody-drug conjugates (ADCs) offer increased efficacy and reduced toxicity compared to systemic chemotherapy. Less attention has been paid to peptide-drug delivery, which has the potential for increased tumor penetration and facile synthesis. We report ... Full text Link to item Cite

127 Multimodality Word-Finding Distinctions in Pediatric Cortical Stimulation Mapping.

Journal Article Neurosurgery · August 2016 INTRODUCTION: Recently, auditory naming has become a part of cortical stimulation mapping (CSM) to provide a comprehensive language map prior to resection in epilepsy patients. Modality-specific language sites have been found using CSM in adult epilepsy pa ... Full text Link to item Cite

Inter-site and inter-scanner diffusion MRI data harmonization.

Journal Article Neuroimage · July 15, 2016 We propose a novel method to harmonize diffusion MRI data acquired from multiple sites and scanners, which is imperative for joint analysis of the data to significantly increase sample size and statistical power of neuroimaging studies. Our method incorpor ... Full text Open Access Link to item Cite

Assessment of obstetric brachial plexus injury with preoperative ultrasound.

Journal Article Muscle Nerve · June 2016 INTRODUCTION: Tools used in the assessment of obstetric brachial plexus injuries (OBPIs) have traditionally included electrodiagnostic studies, computerized tomography with myelography, and MRI. However, the utility of ultrasound (US) in infants for such a ... Full text Link to item Cite

Management of moyamoya syndrome in patients with Noonan syndrome.

Journal Article J Clin Neurosci · June 2016 A few isolated reports have described an association between Noonan syndrome and cerebrovascular abnormalities, including moyamoya syndrome. These reports have been limited to pediatric patients presenting with recurrent transient ischemic attacks (TIA) or ... Full text Link to item Cite

Epilepsy: A Disruptive Force in History.

Journal Article World Neurosurg · June 2016 Since it was first described in a Mesopotamian text in 2000 bc, countless individuals have offered their perspectives on epilepsy's cause, treatment, and even deeper spiritual significance. However, despite the attention the disease has received through th ... Full text Link to item Cite

Radiation-induced brain injury: low-hanging fruit for neuroregeneration.

Journal Article Neurosurg Focus · May 2016 Brain radiation is a fundamental tool in neurooncology to improve local tumor control, but it leads to profound and progressive impairments in cognitive function. Increased attention to quality of life in neurooncology has accelerated efforts to understand ... Full text Link to item Cite

Translational research in traumatic brain injury

Book · April 21, 2016 Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resour ... Cite

Tracking mesenchymal stromal cells using an ultra-bright TAT-functionalized plasmonic-active nanoplatform.

Journal Article J Biophotonics · April 2016 High-resolution tracking of stem cells remains a challenging task. An ultra-bright contrast agent with extended intracellular retention is suitable for in vivo high-resolution tracking of stem cells following the implantation. Here, a plasmonic-active nano ... Full text Link to item Cite

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis.

Journal Article Lancet Oncol · April 2016 BACKGROUND: Patients with incomplete surgical resection of medulloblastoma are controversially regarded as having a marker of high-risk disease, which leads to patients undergoing aggressive surgical resections, so-called second-look surgeries, and intensi ... Full text Open Access Link to item Cite

Sports-related brain injuries: connecting pathology to diagnosis.

Journal Article Neurosurg Focus · April 2016 Brain injuries are becoming increasingly common in athletes and represent an important diagnostic challenge. Early detection and management of brain injuries in sports are of utmost importance in preventing chronic neurological and psychiatric decline. The ... Full text Link to item Cite

Randomized Placebo-Controlled Trial of Methylphenidate or Galantamine for Persistent Emotional and Cognitive Symptoms Associated with PTSD and/or Traumatic Brain Injury.

Journal Article Neuropsychopharmacology · April 2016 We report findings from a 12-week randomized double-blinded placebo-controlled trial of methylphenidate or galantamine to treat emotional and cognitive complaints in individuals (n=32) with a history of PTSD, TBI, or both conditions. In this small pilot st ... Full text Link to item Cite

New tools for studying microglia in the mouse and human CNS.

Journal Article Proc Natl Acad Sci U S A · March 22, 2016 The specific function of microglia, the tissue resident macrophages of the brain and spinal cord, has been difficult to ascertain because of a lack of tools to distinguish microglia from other immune cells, thereby limiting specific immunostaining, purific ... Full text Link to item Cite

Junior Seau: An Illustrative Case of Chronic Traumatic Encephalopathy and Update on Chronic Sports-Related Head Injury.

Journal Article World Neurosurg · February 2016 BACKGROUND: Few neurologic diseases have captured the nation's attention more completely than chronic traumatic encephalopathy (CTE), which has been discovered in the autopsies of professional athletes, most notably professional football players. The tragi ... Full text Link to item Cite

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse.

Journal Article Neuron · January 6, 2016 The functional and molecular similarities and distinctions between human and murine astrocytes are poorly understood. Here, we report the development of an immunopanning method to acutely purify astrocytes from fetal, juvenile, and adult human brains and t ... Full text Link to item Cite

Morphometric Analysis of Predictors of Cervical Syrinx Formation in the Setting of Chiari I Malformation.

Journal Article Pediatr Neurosurg · 2016 BACKGROUND/AIMS: We performed a morphometric analysis of Chiari I malformations to look for predictors of cervical syrinx formation. METHODS: Eighteen patients with Chiari I malformation and associated cervical syrinx and 16 patients with Chiari I malforma ... Full text Link to item Cite

Prenatal evaluation of myelomeningocele: A neurosurgical perspective

Journal Article NeoReviews · January 1, 2016 Myelomeningocele is a neural tube defect that can be diagnosed in utero. The standard of care is postnatal surgery for repair of the open spinal defect, although prenatal surgery is now offered in some institutions. This article considers the prognosis and ... Full text Cite

Telephone Problem-Solving Treatment Improves Sleep Quality in Service Members With Combat-Related Mild Traumatic Brain Injury: Results From a Randomized Clinical Trial.

Journal Article J Head Trauma Rehabil · 2016 OBJECTIVE: Evaluate sleep quality, its correlates, and the effect of telephone-based problem-solving treatment (PST) in active duty postdeployment service members with mild traumatic brain injury (mTBI) SETTING:: Randomized clinical trial. PARTICIPANTS: Ac ... Full text Link to item Cite

Spinal Traction

Chapter · January 1, 2016 Full text Cite

Repeated autologous umbilical cord blood infusions are feasible and had no acute safety issues in young babies with congenital hydrocephalus.

Journal Article Pediatr Res · December 2015 BACKGROUND: Babies with congenital hydrocephalus often experience developmental disabilities due to brain injury associated with prolonged increased pressure on the developing brain parenchyma. Umbilical cord blood (CB) infusion has favorable effects in an ... Full text Open Access Link to item Cite

Pediatric Central Nervous System Tumors in Nepal: Retrospective Analysis and Literature Review of Low- and Middle-Income Countries.

Journal Article World Neurosurg · December 2015 BACKGROUND: Central nervous system (CNS) tumors are the most common cause of cancer-related death in children. Little is known about the demographics and treatment of pediatric brain tumors in low- and middle-income countries (LMICs). METHODS: We performed ... Full text Link to item Cite

Gorlin syndrome and desmoplastic medulloblastoma: Report of 3 cases with unfavorable clinical course and novel mutations.

Journal Article Pediatr Blood Cancer · October 2015 We present three cases of genetically confirmed Gorlin syndrome with desmoplastic medulloblastoma (DMB) in whom tumor recurred despite standard therapy. One patient was found to have a novel germline missense PTCH1 mutation. Molecular analysis of recurrent ... Full text Link to item Cite

Ex vivo generation of dendritic cells from cryopreserved, post-induction chemotherapy, mobilized leukapheresis from pediatric patients with medulloblastoma.

Journal Article J Neurooncol · October 2015 Generation of patient-derived, autologous dendritic cells (DCs) is a critical component of cancer immunotherapy with ex vivo-generated, tumor antigen-loaded DCs. An important factor in the ability to generate DCs is the potential impact of prior therapies ... Full text Link to item Cite

Evolution of cranioplasty techniques in neurosurgery: historical review, pediatric considerations, and current trends.

Journal Article J Neurosurg · October 2015 Cranial bone repair is one of the oldest neurosurgical practices. Reconstructing the natural contours of the skull has challenged the ingenuity of surgeons from antiquity to the present day. Given the continuous improvement of neurosurgical and emergency c ... Full text Link to item Cite

Six Degree-of-Freedom Measurements of Human Mild Traumatic Brain Injury.

Journal Article Ann Biomed Eng · August 2015 This preliminary study investigated whether direct measurement of head rotation improves prediction of mild traumatic brain injury (mTBI). Although many studies have implicated rotation as a primary cause of mTBI, regulatory safety standards use 3 degree-o ... Full text Link to item Cite

Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma.

Journal Article Oncogene · July 2015 Medulloblastoma (MB) is a highly malignant brain tumor that occurs primarily in children. Although surgery, radiation and high-dose chemotherapy have led to increased survival, many MB patients still die from their disease, and patients who survive suffer ... Full text Open Access Link to item Cite

Rapid ventricular pacing for a basilar artery pseudoaneurysm in a pediatric patient: case report.

Journal Article J Neurosurg Pediatr · June 2015 Large cerebral aneurysms of the basilar apex are difficult to treat. Recently, endovascular treatment has mitigated much of the morbidity associated with treating these lesions. However, the morphology of aneurysms of the vertebrobasilar system can preclud ... Full text Link to item Cite

Therapeutic strategies to improve drug delivery across the blood-brain barrier.

Journal Article Neurosurg Focus · March 2015 Resection of brain tumors is followed by chemotherapy and radiation to ablate remaining malignant cell populations. Targeting these populations stands to reduce tumor recurrence and offer the promise of more complete therapy. Thus, improving access to the ... Full text Link to item Cite

Sertraline-induced potentiation of the CYP3A4-dependent neurotoxicity of carbamazepine: an in vitro study.

Journal Article Epilepsia · March 2015 OBJECTIVE: Drug toxicity is a hurdle to drug development and to clinical translation of basic research. Antiepileptic drugs such as carbamazepine (CBZ) and selective serotonin reuptake inhibitors such as sertraline (SRT) are commonly co-prescribed to patie ... Full text Link to item Cite

Joint eQTL assessment of whole blood and dura mater tissue from individuals with Chiari type I malformation.

Journal Article BMC Genomics · January 22, 2015 BACKGROUND: Expression quantitative trait loci (eQTL) play an important role in the regulation of gene expression. Gene expression levels and eQTLs are expected to vary from tissue to tissue, and therefore multi-tissue analyses are necessary to fully under ... Full text Open Access Link to item Cite

Complex fetal care: Implications of fetal ventriculomegaly: A neurosurgical perspective

Journal Article NeoReviews · January 1, 2015 Fetal cerebral ventriculomegaly is diagnosed in utero when the atrial width of at least one lateral ventricle is greater than 10 mm. It is often associated with hydrocephalus, a condition of excessive intracranial cerebrospinal fluid, but can also be relat ... Full text Cite

Vancomycin cerebrospinal fluid pharmacokinetics in children with cerebral ventricular shunt infections.

Journal Article Pediatr Infect Dis J · October 2014 This study described the cerebrospinal fluid (CSF) exposure of vancomycin in 8 children prescribed intravenous vancomycin therapy for cerebral ventricular shunt infection. Vancomycin CSF concentrations ranged from 0.06 to 9.13 mg/L and the CSF: plasma rati ... Full text Link to item Cite

Identification of Chiari Type I Malformation subtypes using whole genome expression profiles and cranial base morphometrics.

Journal Article BMC Med Genomics · June 25, 2014 BACKGROUND: Chiari Type I Malformation (CMI) is characterized by herniation of the cerebellar tonsils through the foramen magnum at the base of the skull, resulting in significant neurologic morbidity. As CMI patients display a high degree of clinical vari ... Full text Open Access Link to item Cite

Editorial comment.

Journal Article Urology · May 2014 Full text Link to item Cite

Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor.

Journal Article Nanoscale · April 21, 2014 Plasmonics-active gold nanostars exhibiting strong imaging contrast and efficient photothermal transduction were synthesized for a novel pulsed laser-modulated plasmonics-enhanced brain tumor microvascular permeabilization. We demonstrate a selective, opti ... Full text Link to item Cite

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.

Journal Article Cancer Cell · March 17, 2014 Smoothened (SMO) inhibitors recently entered clinical trials for sonic-hedgehog-driven medulloblastoma (SHH-MB). Clinical response is highly variable. To understand the mechanism(s) of primary resistance and identify pathways cooperating with aberrant SHH ... Full text Link to item Cite

Genetic evaluation and application of posterior cranial fossa traits as endophenotypes for Chiari type I malformation.

Journal Article Ann Hum Genet · January 2014 Chiari Type I Malformation (CMI) is characterized by herniation of the cerebellar tonsils through the base of the skull. Although cerebellar tonsillar herniation (CTH) is hypothesized to result from an underdeveloped posterior cranial fossa (PF), patients ... Full text Link to item Cite

Optically enhanced blood-brain-barrier crossing of plasmonic-active nanoparticles in preclinical brain tumor animal models

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2014 Nanotechnology provides tremendous biomedical opportunities for cancer diagnosis, imaging, and therapy. In contrast to conventional chemotherapeutic agents where their actual target delivery cannot be easily imaged, integrating imaging and therapeutic prop ... Full text Cite

Mechanisms of cerebral edema leading to early seizures after traumatic brain injury

Chapter · January 1, 2014 Epidemiological data support a link between traumatic brain injury (TBI) and seizures. TBI accounts for approximately 16 % of acute symptomatic seizures which usually occur in the first week after trauma. Children are at higher risk for posttraumatic seizu ... Full text Cite

Preface

Journal Article Proceedings of the International Astronomical Union · January 1, 2014 Cite

Reorganization and stability for motor and language areas using cortical stimulation: case example and review of the literature.

Journal Article Brain Sci · November 26, 2013 The cerebral organization of language in epilepsy patients has been studied with invasive procedures such as Wada testing and electrical cortical stimulation mapping and more recently with noninvasive neuroimaging techniques, such as functional MRI. In the ... Full text Open Access Link to item Cite

Targeting sonic hedgehog-associated medulloblastoma through inhibition of Aurora and Polo-like kinases.

Journal Article Cancer Res · October 15, 2013 Medulloblastoma is the most common malignant brain tumor in children. Although aggressive surgery, radiation, and chemotherapy have improved outcomes, survivors suffer severe long-term side effects, and many patients still succumb to their disease. For pat ... Full text Link to item Cite

How healthcare provider talk with parents of children following severe traumatic brain injury is perceived in early acute care.

Journal Article Soc Sci Med · August 2013 Healthcare provider talk with parents in early acute care following children's severe traumatic brain injury (TBI) affects parents' orientations to these locales, but this connection has been minimally studied. This lack of attention to this topic in previ ... Full text Link to item Cite

Feasibility study of brain tumor delineation using immunolabeled gold nanorods.

Journal Article Biomed Opt Express · 2013 Effective treatment of patients with malignant brain tumors requires surgical resection of a high percentage of the bulk tumor. Surgeons require a method that enables delineation of tumor margins, which are not visually distinct by eye. In this study, the ... Full text Link to item Cite

Feasibility of brain tumor delineation using immunolabeled gold nanorods

Journal Article Optical Molecular Probes, Imaging and Drug Delivery, OMP 2013 · January 1, 2013 The enhanced scattering of gold nanorods in the near-infrared regime provides excellent contrast for imaging within biological tissues. This study demonstrates the capability of anti-EGFR nanorods to distinguish xenograft glioblastomas from healthy murine ... Full text Cite

Parent perceptions of early prognostic encounters following children's severe traumatic brain injury: 'locked up in this cage of absolute horror'.

Journal Article Brain Inj · 2013 OBJECTIVE: Little guidance exists for discussing prognosis in early acute care with parents following children's severe traumatic brain injury (TBI). Providers' beliefs about truth-telling can shape what is said, how it is said and how providers respond to ... Full text Link to item Cite

Sickle erythrocytes target cytotoxics to hypoxic tumor microvessels and potentiate a tumoricidal response.

Journal Article PLoS One · 2013 Resistance of hypoxic solid tumor niches to chemotherapy and radiotherapy remains a major scientific challenge that calls for conceptually new approaches. Here we exploit a hitherto unrecognized ability of sickled erythrocytes (SSRBCs) but not normal RBCs ... Full text Open Access Link to item Cite

Intracranial dual-mode IVUS and hyperthermia using circular arrays: preliminary experiments.

Journal Article Ultrason Imaging · January 2013 In this study, we investigated the feasibility of using 3.5-Fr (3 Fr = 1 mm) circular phased-array intravascular ultrasound (IVUS) catheters for minimally invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated in ... Full text Link to item Cite

Stratified whole genome linkage analysis of Chiari type I malformation implicates known Klippel-Feil syndrome genes as putative disease candidates.

Journal Article PLoS One · 2013 Chiari Type I Malformation (CMI) is characterized by displacement of the cerebellar tonsils below the base of the skull, resulting in significant neurologic morbidity. Although multiple lines of evidence support a genetic contribution to disease, no genes ... Full text Open Access Link to item Cite

In vivo particle tracking and photothermal ablation using plasmon-resonant gold nanostars.

Journal Article Nanomedicine · November 2012 UNLABELLED: Gold nanostars offer unique plasmon properties that efficiently transduce photon energy into heat for photothermal therapy. Nanostars, with their small core size and multiple long thin branches, exhibit high absorption cross-sections that are t ... Full text Link to item Cite

Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways.

Journal Article Proc Natl Acad Sci U S A · October 23, 2012 Myeloid/lymphoid or mixed-lineage leukemia (MLL)-family genes encode histone lysine methyltransferases that play important roles in epigenetic regulation of gene transcription. MLL genes are frequently mutated in human cancers. Unlike MLL1, MLL2 (also know ... Full text Link to item Cite

Management of hearing in pediatric NF2.

Journal Article Otol Neurotol · August 2012 OBJECTIVE: This study will demonstrate an individualized approach to hearing preservation and tumor management in pediatric patients with neurofibromatosis type 2 (NF2). The unique nature of each case discussed will provide valuable guiding principles for ... Full text Link to item Cite

Targeted suppression of claudin-5 decreases cerebral oedema and improves cognitive outcome following traumatic brain injury.

Journal Article Nat Commun · May 22, 2012 Traumatic brain injury is the leading cause of death in children and young adults globally. Malignant cerebral oedema has a major role in the pathophysiology that evolves after severe traumatic brain injury. Added to this is the significant morbidity and m ... Full text Link to item Cite

Trigeminal neuralgia

Chapter · April 12, 2012 Full text Cite

Gold nanostars: surfactant-free synthesis, 3D modelling, and two-photon photoluminescence imaging.

Journal Article Nanotechnology · February 24, 2012 Understanding the control of the optical and plasmonic properties of unique nanosystems--gold nanostars--both experimentally and theoretically permits superior design and fabrication for biomedical applications. Here, we present a new, surfactant-free synt ... Full text Link to item Cite

Plasmonic gold nanostars: A potential agent for molecular imaging and cancer therapy

Journal Article Biomedical Optics, BIOMED 2012 · January 1, 2012 Gold nanostars, with tunable plasmon in the near infrared tissue optic window, generate intense two-photon photoluminescence capable of in vitro cell labeling and in vivo particle tracking. Efficient photothermal ablation therapy is also demonstrated. © 20 ... Full text Cite

Chapter 7. Neuroimaging

Journal Article Pediatric Critical Care Medicine · January 2012 Full text Cite

Chapter 11. Barbiturates

Journal Article Pediatric Critical Care Medicine · January 2012 Full text Cite

Chapter 10. Cerebrospinal fluid drainage

Journal Article Pediatric Critical Care Medicine · January 2012 Full text Cite

Chapter 15. Analgesics, sedatives, and neuromuscular blockade

Journal Article Pediatric Critical Care Medicine · January 2012 Full text Cite

Chapter 3. Indications for intracranial pressure monitoring

Journal Article Pediatric Critical Care Medicine · January 2012 Full text Cite

Chapter 12. Decompressive craniectomy for the treatment of intracranial hypertension

Journal Article Pediatric Critical Care Medicine · January 2012 Full text Cite

Chapter 6. Advanced neuromonitoring

Journal Article Pediatric Critical Care Medicine · January 2012 Full text Cite

Chapter 2. Methods

Journal Article Pediatric Critical Care Medicine · January 2012 Full text Cite

Chapter 8. Hyperosmolar therapy

Journal Article Pediatric Critical Care Medicine · January 2012 Full text Cite

Chapter 14. Corticosteroids

Journal Article Pediatric Critical Care Medicine · January 2012 Full text Cite

Chapter 13. Hyperventilation

Journal Article Pediatric Critical Care Medicine · January 2012 Full text Cite

Chapter 1. Introduction

Journal Article Pediatric Critical Care Medicine · January 2012 Full text Cite

Chapter 10. Cerebrospinal fluid drainage

Journal Article PEDIATRIC CRITICAL CARE MEDICINE · January 1, 2012 Full text Link to item Cite

Chapter 16. Glucose and nutrition

Journal Article Pediatric Critical Care Medicine · January 2012 Full text Cite

Chapter 9. Temperature control

Journal Article Pediatric Critical Care Medicine · January 2012 Full text Cite

Chapter 4. Threshold for treatment of intracranial hypertension

Journal Article Pediatric Critical Care Medicine · January 2012 Full text Cite

Chapter 5. Cerebral perfusion pressure thresholds

Journal Article Pediatric Critical Care Medicine · January 2012 Full text Cite

Inflammatory pseudotumor of the lateral ventricle in a pediatric patient.

Journal Article Pediatr Neurosurg · 2012 Inflammatory pseudotumor (IP) is a benign process that most commonly occurs in the lung and orbit. Extension into the central nervous system is extremely rare, and primary intraventricular lesions of the lateral ventricles are even more infrequent with onl ... Full text Link to item Cite

Clinical Neurosurgery: Preface

Journal Article Clinical Neurosurgery · December 12, 2011 Cite

Controlled synthesis of gold nanorods and application to brain tumor delineation

Conference Optics InfoBase Conference Papers · December 1, 2011 Gold nanorods are candidates for tumor delineation due to their unique optical properties and biocompatibility. The optical characteristics of nanorods are tuned during synthesis. Anti-EGFR nanorods effectively label tumors within brain slices. © 2011 OSA. ... Cite

Intracranial dual-mode IVUS and hyperthermia using circular arrays

Conference IEEE International Ultrasonics Symposium, IUS · December 1, 2011 In this study, we investigated the feasibility of using 3.5-Fr circular phased array IVUS catheters for minimally invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated in two ways: 1) by fitting a 3.5-Fr IVUS ca ... Full text Cite

Molecular imaging true-colour spectroscopic optical coherence tomography.

Journal Article Nat Photonics · December 1, 2011 Molecular imaging holds a pivotal role in medicine due to its ability to provide invaluable insight into disease mechanisms at molecular and cellular levels. To this end, various techniques have been developed for molecular imaging, each with its own advan ... Full text Link to item Cite

Radiographic progression of a Chiari I malformation after minor head trauma: Final increment of obstruction to create pathophysiology

Journal Article Journal of Surgical Radiology · December 1, 2011 Introduction The Chiari I malformation is a rare pathological condition that is characterized by a downward herniation of the cerebellar tonsils and brainstem through the foramen magnum. The transformation from an asymptomatic to symptomatic Chiari I malfo ... Cite

Dual-mode IVUS transducer for image-guided brain therapy: preliminary experiments.

Journal Article Ultrasound Med Biol · October 2011 In this study, we investigated the feasibility of using 3.5-Fr intravascular ultrasound (IVUS) catheters for minimally-invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated by: (1) retro-fitting a commercial 3.5 ... Full text Link to item Cite

Economic analysis of the military health professions scholarship program for neurosurgeons.

Journal Article Neurosurgery · September 2011 BACKGROUND: The 4-year military Health Professions Scholarship Program (HPSP) provides funds for medical school tuition, books, and a monthly stipend in exchange for a 4-year military commitment (to receive all physician bonuses, an additional 3 months mus ... Full text Link to item Cite

Complications following decompression of Chiari malformation Type I in children: dural graft or sealant?

Journal Article J Neurosurg Pediatr · August 2011 OBJECT: Posterior fossa decompression with duraplasty for Chiari malformation Type I (CM-I) is a common pediatric neurosurgery procedure. Published series report a complication rate ranging from 3% to 40% for this procedure. Historically, many dural substi ... Full text Link to item Cite

Structural connectivity of the frontal lobe in children with drug-resistant partial epilepsy.

Journal Article Epilepsy Behav · May 2011 The superior longitudinal fasciculus (SLF) II and cingulum are two white matter tracts important for attention and other frontal lobe functions. These functions are often disturbed in children with drug-resistant (DR) partial epilepsy, even when no abnorma ... Full text Link to item Cite

Compact point-detection fluorescence spectroscopy system for quantifying intrinsic fluorescence redox ratio in brain cancer diagnostics.

Journal Article J Biomed Opt · March 2011 We report the development of a compact point-detection fluorescence spectroscopy system and two data analysis methods to quantify the intrinsic fluorescence redox ratio and diagnose brain cancer in an orthotopic brain tumor rat model. Our system employs on ... Full text Link to item Cite

Controlled synthesis of gold nanorods and application to brain tumor delineation

Conference Optics InfoBase Conference Papers · January 1, 2011 Gold nanorods are candidates for tumor delineation due to their unique optical properties and biocompatibility. The optical characteristics of nanorods are tuned during synthesis. Anti-EGFR nanorods effectively label tumors within brain slices. © 2011 OSA. ... Full text Cite

Erratum: Dual-mode IVUS catheter for intracranial image-guided hyperthermia: Feasibility study (IEEE Trans. Ultrason. Ferroelectr. Freq. Control)

Journal Article IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control · January 1, 2011 Full text Cite

Clinical Neurosurgery: Preface

Journal Article Clinical Neurosurgery · December 1, 2010 Cite

Clinical outcome of cerebrospinal fluid shunting for communicating hydrocephalus in mucopolysaccharidoses I, II, and III: a retrospective analysis of 13 patients.

Journal Article Neurosurgery · December 2010 BACKGROUND: Intracranial pathology is a well-documented feature of mucopolysaccharidoses (MPSs), including communicating hydrocephalus (CH). Neither the success nor the complications of cerebrospinal fluid shunting in MPS patients have been well documented ... Full text Open Access Link to item Cite

Intracranial dual-mode IVUS transducer for image-guided brain therapypreliminary experiments

Journal Article Proceedings - IEEE Ultrasonics Symposium · December 1, 2010 In this study, we investigated the feasibility of using 3.5-Fr IVUScatheters for minimally-invasive, image-guided hyperthermia treatment of tumorsin the brain. Feasibility is demonstrated in two ways: 1) by fitting a 3.5-FrIVUS catheter with a 5 × 0.5 × 0. ... Full text Cite

Comments

Other Neurosurgery · December 1, 2010 Full text Cite

Dual-mode IVUS catheter for intracranial image-guided hyperthermia: feasibility study.

Journal Article IEEE Trans Ultrason Ferroelectr Freq Control · November 2010 In this study, we investigated the feasibility of modifying 3-Fr IVUS catheters in several designs to potentially achieve minimally-invasive, endovascular access for image-guided ultrasound hyperthermia treatment of tumors in the brain. Using a plane wave ... Full text Link to item Cite

Guidelines for the management of obstructive hydrocephalus from suprasellar-prepontine arachnoid cysts using endoscopic third ventriculocystocisternostomy.

Journal Article Surg Innov · September 2010 Intracranial endoscopy has emerged as an innovative surgical tool for various intracranial procedures, but its use remains limited to neurosurgeons trained in this minimally invasive technique. Complex, skull base arachnoid cysts represent one entity that ... Full text Link to item Cite

Endodermal cyst of the oculomotor nerve.

Journal Article Pediatr Neurosurg · August 2010 Full text Link to item Cite

Investigation of synchronous fluorescence method in multicomponent analysis in tissue

Journal Article IEEE Journal on Selected Topics in Quantum Electronics · July 1, 2010 We investigate the advantages and disadvantages of the synchronous fluorescence (SF) scan method as compared with the fixed-excitation or fixed-emission fluorescence methods in analyzing biological tissue samples or tissue-like synthetic phantoms by quanti ... Full text Cite

Single-stage bilateral choroid plexectomy for choroid plexus papilloma in a patient presenting with high cerebrospinal fluid output.

Journal Article J Neurosurg Pediatr · April 2010 Cerebrospinal fluid overproduction resulting in communicating hydrocephalus is observed in patients who have choroid plexus papilloma or choroid plexus carcinoma. Less often, patients with these conditions have diffuse villous hyperplasia. Prior studies re ... Full text Link to item Cite

Disappearing bone disease and Chiari I malformation.

Journal Article Pediatr Neurosurg · 2010 Gorham's disease is a rare disorder in which massive osteolysis occurs within bone, and therefore earns its historical name: disappearing bone disease. We describe a case of Chiari I malformation in a patient with this rare disorder, with treatment consist ... Full text Link to item Cite

Isolated intracranial Rosai-Dorfman disease in a child.

Journal Article AJNR Am J Neuroradiol · November 2009 Full text Link to item Cite

Intracranial catheter for integrated 3D ultrasound imaging & hyperthermia: Feasibility study

Conference AIP Conference Proceedings · July 21, 2009 In this study, we investigated the feasibility of an intracranial catheter transducer capable of real-time 3D (RT3D) imaging and ultrasound hyperthermia, for application in the visualization and treatment of tumors in the brain. We designed and constructed ... Full text Cite

Tympanic membrane perforation after combat blast exposure in Iraq: a poor biomarker of primary blast injury.

Journal Article J Trauma · July 2009 OBJECTIVE: The US military has reported over 10,000 improvised explosive device attacks attributing to over 400 deaths in Iraq in 2005. Otologic blast injury and tympanic membrane (TM) perforation have traditionally been used as a predictor, or biomarker, ... Full text Link to item Cite

Explosive blast neurotrauma.

Journal Article J Neurotrauma · June 2009 Explosive blast traumatic brain injury (TBI) is one of the more serious wounds suffered by United States service members injured in the current conflicts in Iraq and Afghanistan. Some military medical treatments for blast TBI that have been introduced succ ... Full text Link to item Cite

Transciliary orbitofrontozygomatic approach to lesions of the anterior cranial fossa.

Journal Article Neurosurgery · May 2009 OBJECTIVE: Several variations on the supraorbital craniotomy via a forehead or eyebrow incision have been described in the literature in recent years. A modification of this approach, the transciliary orbitofrontozygomatic approach, has been used by the au ... Full text Link to item Cite

Dual-mode intracranial catheter integrating 3D ultrasound imaging and hyperthermia for neuro-oncology: feasibility study.

Journal Article Ultrason Imaging · April 2009 In this study, we investigated the feasibility of an intracranial catheter transducer with dual-mode capability of real-time 3D (RT3D) imaging and ultrasound hyperthermia, for application in the visualization and treatment of tumors in the brain. Feasibili ... Full text Link to item Cite

Molecular imaging and quantitative measurement of epidermal growth factor receptor expression in live cancer cells using immunolabeled gold nanoparticles.

Journal Article AJR Am J Roentgenol · April 2009 OBJECTIVE: The goal of this study was to assess whether immunolabeled nanoparticle biomarkers are comparable to fluorescent marker imaging in measuring epidermal growth factor receptor (EGFR) expression. MATERIALS AND METHODS: EGFR expression was quantifie ... Full text Link to item Cite

Spontaneous intrauterine "ping-pong" fracture: review and case illustration.

Journal Article Neuropediatrics · April 2009 We report a case of a closed outer-table parietal "ping-pong" skull fracture occurring in a 4 190-gram female infant born at 39 weeks and 5 days gestation after an uneventful Cesarean section (Apgar scores of 9 and 9 at one and five minutes). There was no ... Full text Link to item Cite

Spontaneous resolution of a 13-mm Chiari malformation Type I in relation to differential growth of the posterior fossa volume.

Journal Article J Neurosurg Pediatr · February 2009 The case of a 3-year-old patient with tuberous sclerosis and a 13-mm Chiari malformation Type I that spontaneously disappeared over the course of 4 years is presented. Using morphometric measurements of the posterior fossa and cerebellum in this patient, t ... Full text Link to item Cite

Few isolated neurons in hypothalamic hamartomas may cause gelastic seizures.

Journal Article Pediatr Neurosurg · 2009 Hypothalamic hamartomas (HHs) are congenital, benign masses in the hypothalamus and tuber cinereum that may cause central precocious puberty and gelastic seizures. Nodules of small neurons are thought to be a universal feature of the microarchitecture of H ... Full text Link to item Cite

Dual-mode intracranial catheters for minimally-invasive neuro-oncology feasibility study

Journal Article Proceedings - IEEE Ultrasonics Symposium · January 1, 2009 In this study, we investigated the feasibility of dual-mode intracranial catheter transducers for visualization and treatment of tumors in the brain. Feasibility is demonstrated in two ways: 1) by developing a 12 Fr, integrated matrix and linear array cath ... Full text Cite

Congenital thoracolumbar spine deformities.

Journal Article Neurosurgery · September 2008 Congenital thoracolumbar spinal deformities are a common and frequent reason for referral to spine surgeons. Neurosurgeons also treat many neurological diagnoses which may result in a progressive spinal deformity, such as scoliosis. Here we review a variet ... Full text Link to item Cite

Development of an acquired Chiari malformation Type I in the setting of an untreated lipomyelomeningocele. Case report.

Journal Article J Neurosurg Pediatr · February 2008 The authors present the case of a child with an untreated lipomyelomeningocele who developed an acquired Chiari malformation Type I (CM-I) with a large syrinx over the course of 3 years. To the best of the authors' knowledge, this is the first report to do ... Full text Link to item Cite

Update on hemostasis: neurosurgery.

Journal Article Surgery · October 2007 Achieving and maintaining hemostasis in neurosurgical procedures is critical to the outcome. After trauma to the brain, a cascade of events initiated by tissue factor (TF) or thromboplastin results in a coagulation process that develops into an exaggerated ... Full text Link to item Cite

Dynamic contrast-enhanced magnetic resonance angiography of vascular malformations in pediatric patients. Case report.

Journal Article J Neurosurg · September 2007 The authors report the first clinical use of 3-tesla dynamic contrast-enhanced magnetic resonance (MR) angiography for the diagnosis of a vascular malformation in a pediatric patient. The supply and drainage of an arteriovenous malformation were accurately ... Full text Link to item Cite

MR neurography: diagnostic utility in the surgical treatment of peripheral nerve disorders.

Journal Article Neuroimaging Clin N Am · February 2004 Advances in MR imaging have improved the visualization of normal and pathologic peripheral nerve structures in various clinical settings. Peripheral nerve imaging has the potential to dramatically change the diagnosis and treatment of peripheral nerve path ... Full text Link to item Cite

Failure of autologous bone-assisted cranioplasty following decompressive craniectomy in children and adolescents.

Journal Article J Neurosurg · February 2004 OBJECT: The authors have routinely performed primary autologous cranioplasty to repair skull defects after decompressive craniectomy. The high rates of subsequent bone resorption occurring in children prompted this study. METHODS: In an institutional revie ... Full text Link to item Cite

A large planum sphenoidale meningioma with sinonasal extension in a child. Case report and review of the literature.

Journal Article Pediatr Neurosurg · November 2003 Anterior cranial base meningiomas are rare tumors in children. Due to the extensive involvement of orbit, paranasal sinuses, midface, and anterior skull base, a multidisciplinary approach is warranted. We present a case of a child with a large planum sphen ... Full text Link to item Cite

Adenosine-induced modulation of excitatory amino acid transport across isolated brain arterioles.

Journal Article J Neurosurg · March 2003 OBJECT: Excitatory amino acid (EAA) uptake by neurons and glia acts synergistically with stereoselective transport across the blood-brain barrier (BBB) to maintain EAA homeostasis in the brain. The endogenous neuroprotectant adenosine counteracts many aspe ... Full text Link to item Cite

Long-term safety and efficacy of continuous intrathecal baclofen.

Journal Article Dev Med Child Neurol · October 2002 Long-term continuous intrathecal baclofen (CITB) infusion is a treatment option used to manage otherwise intractable spasticity and is delivered via an implantable pump. The purpose of this single-center multidisciplinary review was to report on the long-t ... Full text Link to item Cite

Continuous somatosensory evoked potential monitoring during brain tumor resection. Report of four cases and review of the literature.

Journal Article J Neurosurg · September 2002 The neurosurgical management of intrinsic brain tumors and brain metastases mandates maximum resection with preservation of functional cortex. There have been previous reports on the use of cortical somatosensory evoked potentials (SSEPs) for localization ... Full text Link to item Cite

Delayed facial palsy after resection of vestibular schwannoma.

Journal Article J Neurosurg · July 2002 OBJECT: In this study the authors investigate delayed facial palsy (DFP), which is an underreported phenomenon after surgery for vestibular schwannoma (VS). The authors identified 15 (4.8%) patients from a consecutive series of 314 who underwent surgery fo ... Full text Link to item Cite

The utility of magnetic resonance imaging in evaluating peripheral nerve disorders.

Journal Article Muscle Nerve · March 2002 The evaluation of peripheral nerve injuries has traditionally relied primarily on information gained from the clinical history, physical examination, and electrodiagnostic testing. Taken together, all of this clinical and diagnostic information often allow ... Full text Link to item Cite

Controversies in the management of craniosynostosis

Journal Article Seminars in Neurosurgery · January 1, 2002 This article updates the general neurosurgeon on the current issues and controversies in craniofacial surgery. Topics discussed include differential diagnosis of posterior plagiocephaly, timing of craniosynostosis surgery, technical advances, intracranial ... Full text Cite

Effect of papaverine on intraoperative BAEPs

Journal Article Neurodiagnostic Journal · January 1, 2002 Papaverine is a vasodilator agent that exerts a spasmolytic effect on smooth muscles, including cerebral blood vessels. We are not aware of reported cases of adverse effects of papaverine on evoked potentials. Two patients undergoing surgery for microvascu ... Full text Cite

Treatment of recurrent peripheral nerve entrapment problems: role of scar formation and its possible treatment.

Journal Article Neurosurg Clin N Am · April 2001 Surgical management of peripheral nerve entrapment syndromes is usually successful, but the recurrence of symptoms after initial improvement can and does occur. Extraneural fibrosis is one possible cause of recurrent peripheral nerve problems as a result o ... Link to item Cite

Development of an in vitro blood-brain barrier.

Journal Article Curr Protoc Toxicol · 2001 The blood-brain barrier represents a significant protective barrier for the passage of pathogens and toxicants, but it is difficult to study in vivo. This unit describes an in vitro system that can be used as a model for the blood-brain barrier to study it ... Full text Link to item Cite

A new model of the blood--brain barrier: co-culture of neuronal, endothelial and glial cells under dynamic conditions.

Journal Article Neuroreport · December 16, 1999 Developing in vitro blood-brain barrier (BBB) models that closely mimic the natural state is important for theoretical and practical applications, including drug development. We previously developed an in vitro BBB model based on co-culturing endothelial c ... Full text Link to item Cite

Management of intrinsic gliomas of the tectal plate in children. A ten-year review.

Journal Article Pediatr Neurosurg · October 1999 The natural history, management, and long-term outcome for patients with benign, intrinsic tectal plate gliomas remain controversial in spite of their propensity to cause late-onset hydrocephalus. A 10-year retrospective review has identified 11 consecutiv ... Full text Link to item Cite

Recurrent intracranial Masson's vegetant intravascular hemangioendothelioma. Case report and review of the literature.

Journal Article J Neurosurg · August 1999 In the central nervous system, recurrence of intracranial Masson's vegetant intravascular hemangioendothelioma (MVIH) is rare. To the authors' knowledge, only three recurrent intracranial cases have been reported. The authors report the case of a 75-year-o ... Full text Link to item Cite

Evaluation and surgical management of peripheral nerve problems.

Journal Article Neurosurgery · April 1999 OBJECTIVE: To illustrate how an understanding of the basic biological responses of peripheral nerves to injury is important in formulating a rational treatment plan. METHODS: Peripheral nerve anatomy and physiology are described in a context that is releva ... Full text Link to item Cite

Solitary eosinophilic granuloma of the temporal lobe: case report and review of the literature.

Journal Article Brain Tumor Pathol · 1999 A solitary eosinophilic granuloma of the central nervous system is an unusual manifestation of histiocytosis X. A unique case of a solitary eosinophilic granuloma of the right temporal lobe without osseous involvement is described. A 20-year-old man presen ... Full text Link to item Cite

Risk of early closed reduction in cervical spine subluxation injuries.

Journal Article J Neurosurg · January 1999 OBJECT: The authors retrospectively reviewed 121 patients with traumatic cervical spine injuries to determine the risk of neurological deterioration following early closed reduction. METHODS: After excluding minor fractures and injuries without subluxation ... Full text Link to item Cite

Destructive tophaceous calcium hydroxyapatite tumor of the infratemporal fossa. Case report and review of the literature.

Journal Article J Neurosurg · January 1999 Tophaceous pseudogout is one of the rarest forms of crystal deposition disease, typically presenting as a destructive and invasive mass involving the temporomandibular joint or the infratemporal fossa region in the absence of any other articular manifestat ... Full text Link to item Cite

Accuracy of continuous jugular bulb oximetry in the intensive care unit.

Journal Article Neurosurgery · March 1998 OBJECTIVE: To address the accuracy of a bedside jugular bulb oxygen saturation (SjO2) catheter monitor (Baxter-Edwards, Santa Ana, CA) versus in vitro co-oximetry measurements in the intensive care unit (ICU). METHODS: By prospective protocol, we compared ... Full text Link to item Cite

Understanding the physiology of the blood-brain barrier: In vitro models

Journal Article News in Physiological Sciences · January 1, 1998 Endothelial cells exposed to inductive central nervous system factors differentiate into a blood-brain barrier phenotype. The blood-brain barrier frequently obstructs the passage of chemotherapeutics into the brain. Tissue culture systems have been develop ... Full text Cite

Thrombotic, infectious, and procedural complications of the jugular bulb catheter in the intensive care unit.

Journal Article Neurosurgery · July 1997 OBJECTIVE: An assessment of the thrombotic, infectious, and technical complications of continuous jugular bulb catheter monitoring in the intensive care unit (ICU) was made. METHODS: Over a 1-year period, 44 patients suffering from traumatic brain injury, ... Full text Link to item Cite

Cerebral autoregulation following minor head injury.

Journal Article J Neurosurg · March 1997 The purpose of this study was to determine whether patients with minor head injury experience impairments in cerebral autoregulation. Twenty-nine patients with minor head injuries defined by Glasgow Coma Scale (GCS) scores of 13 to 15 underwent testing of ... Full text Link to item Cite

Neuroprotection by N-methyl-D-aspartate antagonists in focal cerebral ischemia is dependent on continued maintenance dosing.

Journal Article Neuroscience · January 1995 While N-methyl-D-aspartate antagonists have been shown to attenuate neuronal damage in focal cerebral ischemia, few studies have examined whether continuous or multiple dose treatment is necessary for maximum efficacy. We studied the effect of a loading do ... Full text Link to item Cite

Protection against focal cerebral ischemia following exposure to a pulsed electromagnetic field.

Journal Article Bioelectromagnetics · 1994 There is evidence that electromagnetic stimulation may accelerate the healing of tissue damage following ischemia. We undertook this study to investigate the effects of low frequency pulsed electromagnetic field (PEMF) exposure on cerebral injury in a rabb ... Full text Link to item Cite

Dextromethorphan alters cerebral blood flow and protects against cerebral injury following focal ischemia.

Journal Article Neurosci Lett · December 9, 1991 The effects of the N-methyl-D-aspartate (NMDA) antagonist dextromethorphan (DM) on regional cerebral blood flow (rCBF) and cerebral injury were studied in a rabbit model of transient focal ischemia. Anesthetized rabbits underwent 2 h occlusion of the left ... Full text Link to item Cite