Scholars@Duke
Henry Seth Friedman

Henry Seth Friedman

James B. Powell, Jr. Distinguished Professor of Pediatric Oncology, in the School of Medicine
Neurosurgery, Neuro-Oncology
henry.friedman@duke.edu
Box 3624 Med Ctr, Durham, NC 27710
047 Baker House, Durham, NC 27710

Selected Publications

A real-world observation of patients with glioblastoma treated with a personalized peptide vaccine.

Journal Article Nat Commun · August 11, 2024 Current treatment outcome of patients with glioblastoma (GBM) remains poor. Following standard therapy, recurrence is universal with limited survival. Tumors from 173 GBM patients are analysed for somatic mutations to generate a personalized peptide vaccin ... Full text Link to item Cite

Use, access, and initial outcomes of off-label ivosidenib in patients with IDH1 mutant glioma.

Journal Article Neurooncol Pract · April 2024 BACKGROUND: Isocitrate dehydrogenase (IDH) is commonly mutated (mIDH) in gliomas, and this mutant enzyme produces the oncometabolite 2-hydroxyglutarate (2HG). 2HG promotes gliomagenesis and is implicated in epileptogenesis. Ivosidenib (IVO), a small molecu ... Full text Link to item Cite

Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma.

Journal Article J Clin Oncol · November 10, 2023 PURPOSE: We evaluated the efficacy of bevacizumab, alone and in combination with irinotecan, in patients with recurrent glioblastoma in a phase II, multicenter, open-label, noncomparative trial. PATIENTS AND METHODS: One hundred sixty-seven patients were r ... Full text Link to item Cite

Recombinant polio-rhinovirus immunotherapy for recurrent paediatric high-grade glioma: a phase 1b trial.

Journal Article Lancet Child Adolesc Health · July 2023 BACKGROUND: Outcomes of recurrent paediatric high-grade glioma are poor, with a median overall survival of less than 6 months. Viral immunotherapy, such as the polio-rhinovirus chimera lerapolturev, is a novel approach for treatment of recurrent paediatric ... Full text Link to item Cite

Abstract 4924: Alternative lengthening of telomeres is associated with hypersensitivity to topoisomerase 1 inhibition in glioblastoma xenograft models

Conference Cancer Research · April 4, 2023 AbstractGlioblastoma (GBM), the most common primary malignant brain tumor in adults, is an incurable disease that has an inevitable tendency to recur following standard of care surgery, radiotherapy, and tem ... Full text Cite

NCOG-43. A RETROSPECTIVE ANALYSIS OF THE IMPACT OF THE COVID-19 INFECTION ON NEURO-ONCOLOGY CARE AND PATIENT OUTCOMES: A TWO-SITE STUDY

Conference NEURO-ONCOLOGY · November 14, 2022 BACKGROUND COVID-19 radically changed neuro-oncology care. In this retrospective study, we examine the impact of COVID-19 infection on neuro-oncological care and clinical outcomes in two geographically separate populations. METHODS Descriptive statistics ... Full text Link to item Cite

Effects of low-dose naltrexone on quality of life in high-grade glioma patients: a placebo-controlled, double-blind randomized trial.

Journal Article Support Care Cancer · April 2022 PURPOSE: At diagnosis and throughout the disease course, patients with high-grade glioma (HGG) experience a diminished quality of life (QOL) and increased fatigue. Naltrexone, an orally semisynthetic opiate antagonist, is FDA-approved for the treatment of ... Full text Link to item Cite

Long-Term Outcomes for Patients With Atypical or Malignant Meningiomas Treated With or Without Radiation Therapy: A 25-Year Retrospective Analysis of a Single-Institution Experience.

Journal Article Adv Radiat Oncol · 2022 PURPOSE: Atypical (World Health Organization [WHO] grade 2) and malignant (WHO grade 3) meningiomas have high rates of local recurrence, and questions remain about the role of adjuvant radiation therapy (RT) for patients with WHO grade 2 disease. These pat ... Full text Link to item Cite

A phase 1 trial of D2C7-it in combination with an Fc-engineered anti-CD40 monoclonal antibody (2141-V11) administered intratumorally via convectionenhanced delivery for adult patients with recurrent malignant glioma (MG).

Conference JOURNAL OF CLINICAL ONCOLOGY · 2022 Background: D2C7 immunotoxin (D2C7-IT) is a dual-specific recombinant immunotoxin comprising an EGFR wild-type and mutant-specific (EGFRvIII) monoclonal antibody (Ab) fragment and a genetically engineered form of the Pseudomonas exotoxin. When injected dir ... Full text Link to item Cite

A phase 0/surgical window-of-opportunity study in progress, evaluating evolocumab in patients with high-grade glioma or glioblastoma

Conference JOURNAL OF CLINICAL ONCOLOGY · 2022 Background: High-grade gliomas (HGGs) are immunologically ‘cold’ tumors. This phenomenon is partly due to reduced expression of major histocompatibility class (MHC) I on the surface of tumor cells, which prevents CD8+ cytotoxic T lymphocyte activity (CTLs) ... Full text Link to item Cite

QOLP-28. COMPARING KNOWLEDGE OF AND BELIEFS ABOUT PALLIATIVE CARE AMONG NEURO-ONCOLOGY PATIENTS, CAREGIVERS, PROVIDERS AND A NATIONALLY-REPRESENTATIVE U.S. SAMPLE

Conference Neuro-Oncology · November 12, 2021 AbstractINTRODUCTIONThere is increasing recognition that palliative care (PC) can benefit patients with advanced cancers. However, ear ... Full text Open Access Link to item Cite

INNV-20. RADIOGRAPHIC RESPONSE AND SEIZURE CONTROL IN IDH1 MUTANT GLIOMA PATIENTS USING IVOSIDENIB

Conference Neuro-Oncology · November 12, 2021 AbstractIsocitrate dehydrogenase 1 (IDH1) is commonly mutated in grade II-III gliomas, and the mutant enzyme leads to the production of the oncometabolite 2-hydroxyglutarate (2-HG). 2-HG is responsible for t ... Full text Open Access Link to item Cite

CTIM-10. REPRODUCIBILITY OF CLINICAL TRIALS USING CMV-TARGETED DENDRITIC CELL VACCINES IN PATIENTS WITH GLIOBLASTOMA

Conference Neuro-Oncology · November 12, 2021 AbstractINTRODUCTIONVaccination with dendritic cells (DCs) fares poorly in primary and recurrent glioblastoma (GBM). Moreover, GBM vac ... Full text Open Access Link to item Cite

Primary brain tumor patients admitted to a US intensive care unit: a descriptive analysis.

Journal Article CNS Oncol · September 1, 2021 Purpose: To describe our population of primary brain tumor (PBT) patients, a subgroup of cancer patients whose intensive care unit (ICU) outcomes are understudied. Methods: Retrospective analysis of PBT patients admitted to an ICU between 2013 to 2018 for ... Full text Open Access Link to item Cite

Spiritual well-being and its association with health-related quality of life in primary brain tumor patients.

Journal Article Neurooncol Pract · June 2021 BACKGROUND: Spirituality can impact patients' attitudes and decisions about treatment and end-of-life care when coping with cancer. Previous studies documented health-related quality of life (HRQoL) and spiritual well-being (SWB) as positively correlated w ... Full text Link to item Cite

LUMINOS-101: Phase 2 study of PVSRIPO with pembrolizumab in recurrent glioblastoma.

Conference Journal of Clinical Oncology · May 20, 2021 TPS2065 Background: The prognosis for patients (pts) with recurrent (r) glioblastoma (GBM) is poor, with no highly effective approved therapies. Treatment failure may result from poor penetration of drugs through the blood-brain ... Full text Cite

Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy.

Journal Article Nat Commun · January 13, 2021 Several immunotherapy clinical trials in recurrent glioblastoma have reported long-term survival benefits in 10-20% of patients. Here we perform genomic analysis of tumor tissue from recurrent WHO grade IV glioblastoma patients acquired prior to immunother ... Full text Open Access Link to item Cite

Adjuvant Radiation in Older Patients With Glioblastoma: A Retrospective Single Institution Analysis.

Journal Article Front Oncol · 2021 OBJECTIVES: Standard 6-week and hypofractionated 3-week courses of adjuvant radiation therapy (RT) are both options for older patients with glioblastoma (GBM), but deciding the optimal regimen can be challenging. This analysis explores clinical factors ass ... Full text Open Access Link to item Cite

Outcomes Following Adjuvant Radiation Therapy in Elderly Patients with Glioblastoma: A Retrospective Single Institution Analysis

Conference International Journal of Radiation Oncology*Biology*Physics · September 1, 2020 2230 ... Full text Link to item Cite

Management of glioblastoma: State of the art and future directions.

Journal Article CA Cancer J Clin · July 2020 Glioblastoma is the most common malignant primary brain tumor. Overall, the prognosis for patients with this disease is poor, with a median survival of <2 years. There is a slight predominance in males, and incidence increases with age. The standard approa ... Full text Link to item Cite

Randomized open-label phase II trial of 5-day aprepitant plus ondansetron compared to ondansetron alone in the prevention of chemotherapy-induced nausea-vomiting (CINV) in glioma patients receiving adjuvant temozolomide.

Journal Article Support Care Cancer · May 2020 PURPOSE: CINV remains a distressing side effect experienced by glioma patients receiving multi-day temozolomide therapy, in spite of guideline-based antiemetic therapy with selective serotonin-receptor-antagonists. Antiemetic research with aprepitant has r ... Full text Link to item Cite

Patterns of relapse after successful completion of initial therapy in primary central nervous system lymphoma: a case series.

Journal Article J Neurooncol · April 2020 PURPOSE: Primary central nervous system lymphoma (PCNSL) is a subtype of non-Hodgkin's lymphoma that involves the brain, spinal cord, or leptomeninges, without evidence of systemic disease. This rare disease accounts for ~ 3% of all primary central nervous ... Full text Link to item Cite

The role of chemotherapy in the treatment of central neurocytoma.

Journal Article CNS Oncol · November 1, 2019 Aim: Central neurocytoma (CN) is a rare WHO grade II central nervous system (CNS) tumor. This is an update on chemotherapeutic agents used in its treatment. Patients & methods: An institutional review board-approved, chart review of patients seen at our in ... Full text Open Access Link to item Cite

Second primary cancers in long-term survivors of glioblastoma.

Journal Article Neurooncol Pract · September 2019 BACKGROUND: Overall survival (OS) in glioblastoma (GBM) is poor at an average of 14 to 18 months, and long-term survivors (LTS) of GBM are rare. LTS of GBM, defined as surviving >5 years postdiagnosis, represent only 2% to 10% of all GBM patients. LTS of c ... Full text Link to item Cite

Complementary and integrative health interventions and their association with health-related quality of life in the primary brain tumor population.

Journal Article Complement Ther Clin Pract · August 2019 BACKGROUND AND PURPOSE: Little is known about complementary and integrative health intervention usage in the primary brain tumor population. We aimed to identify the percentage of patients using these practices and explore the impact on quality of life. MA ... Full text Link to item Cite

MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation.

Journal Article Cancer Res · July 1, 2019 Homozygous deletion of methylthioadenosine phosphorylase (MTAP) is one of the most frequent genetic alterations in glioblastoma (GBM), but its pathologic consequences remain unclear. In this study, we report that loss of MTAP results in profound epigenetic ... Full text Link to item Cite

Safety of nivolumab in combination with dendritic cell vaccines in recurrent high-grade glioma.

Conference Journal of Clinical Oncology · May 20, 2019 e13526 Background: Recurrence of high-grade glioma (HGG) (WHO grade III-IV) is a nearly universal phenomenon and necessitates the development of new therapeutic modalities. Two possible immunotherapeutic modalities are checkpoint ... Full text Cite

Oncolytic polio/rhinovirus recombinant (PVSRIPO) against WHO grade IV malignant glioma (MG): Experience with retreatment of survivors from the phase I trial.

Conference Journal of Clinical Oncology · May 20, 2019 2060 Background: We completed a study evaluating a single intratumoral delivery of PVSRIPO in recurrent WHO grade IV MG patients (N Engl J Med. 2018 Jul 12;379(2):150-161). Some patients who originally benefitted from the infusion of PVSRIPO demonstrated ... Full text Link to item Cite

Single-institution retrospective review of patients with recurrent glioblastoma treated with bevacizumab in clinical practice.

Journal Article Health Sci Rep · April 2019 BACKGROUND AND AIMS: This retrospective review of patients with recurrent glioblastoma treated at the Preston Robert Tisch Brain Tumor Center investigated treatment patterns, survival, and safety with bevacizumab in a real-world setting. METHODS: Adult pat ... Full text Link to item Cite

MGMT: Immunohistochemical Detection in High-Grade Astrocytomas.

Journal Article J Neuropathol Exp Neurol · January 1, 2019 Glioma therapeutic resistance to alkylating chemotherapy is mediated via O6-methylguanine-DNA methyltransferase (MGMT). We hypothesized that a CD45/HAM56/MGMT double-stained cocktail would improve MGMT discrimination in tumor cells versus inflammatory and ... Full text Link to item Cite

Pilot Study to Describe the Trajectory of Symptoms and Adaptive Strategies of Adults Living with Low-grade Glioma.

Journal Article Semin Oncol Nurs · December 2018 OBJECTIVES: To describe the adaptability to the patterns in symptoms and quality of life (QoL) during 6 months post low-grade glioma diagnosis by valid and reliable tools; to identify through qualitative interviews patient/provider adaptive techniques and ... Full text Link to item Cite

Phase II Study to Evaluate the Efficacy and Safety of Rilotumumab and Bevacizumab in Subjects with Recurrent Malignant Glioma.

Journal Article Oncologist · August 2018 LESSONS LEARNED: Due to evolving imaging criteria in brain tumors and variation in magnetic resonance imaging evaluation, it is not ideal to use response rate as a primary objective. Future studies involving antiangiogenic agents should use overall surviva ... Full text Link to item Cite

Recurrent Glioblastoma Treated with Recombinant Poliovirus.

Journal Article N Engl J Med · July 12, 2018 BACKGROUND: The prognosis of patients with recurrent World Health Organization (WHO) grade IV malignant glioma is dismal, and there is currently no effective therapy. We conducted a dose-finding and toxicity study in this population of patients, evaluating ... Full text Link to item Cite

Sym004-induced EGFR elimination is associated with profound anti-tumor activity in EGFRvIII patient-derived glioblastoma models.

Journal Article J Neurooncol · July 2018 BACKGROUND: Sym004 is a mixture of two monoclonal antibodies (mAbs), futuximab and modotuximab, targeting non-overlapping epitopes on the epidermal growth factor receptor (EGFR). Previous studies have shown that Sym004 is more efficient at inducing interna ... Full text Open Access Link to item Cite

The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma.

Journal Article Nat Commun · May 25, 2018 The majority of glioblastomas can be classified into molecular subgroups based on mutations in the TERT promoter (TERTp) and isocitrate dehydrogenase 1 or 2 (IDH). These molecular subgroups utilize distinct genetic mechanisms of telomere maintenance, eithe ... Full text Link to item Cite

Long-term outcomes of adult patients with ependymoma.

Conference Neurology · April 27, 2018 150 ... Link to item Cite

Long-term outcomes of adult patients with ependymoma.

Journal Article Neurology · April 10, 2018 150 ... Link to item Cite

Adult pilocytic astrocytoma: clinical management and prognostic factors.

Conference Neurology · April 9, 2018 158 Objective: The purpose of this study is to analyze adult patients with pilocytic astrocytomas and to identify factors associated with recurrence and survival. Background: Pilocytic astrocytomas (WHO grade I) represent the most common central nervous s ... Link to item Cite

Phase I/II trial of vorinostat, bevacizumab, and daily temozolomide for recurrent malignant gliomas.

Journal Article J Neurooncol · April 2018 Prognosis of recurrent glioblastoma (GBM) is poor with 6-month progression-free survival (PFS6) ranging from 9 to 48% depending on the treatment regimen and use of anti-angiogenic therapies. We sought to study vorinostat (VOR), a histone deacetylase inhibi ... Full text Link to item Cite

Non-communicable chronic diseases and timely breast cancer screening among women of the Eastern Caribbean Health Outcomes Research Network (ECHORN) Cohort Study.

Journal Article Cancer Causes Control · March 2018 PURPOSE: The Caribbean population faces a growing burden of multiple non-communicable chronic diseases (NCDs). Breast cancer is the leading cause of cancer death for women in the Caribbean. Given the substantial burden of NCDs across the region, cancer pre ... Full text Link to item Cite

Phase II Study of Bevacizumab and Vorinostat for Patients with Recurrent World Health Organization Grade 4 Malignant Glioma.

Journal Article Oncologist · February 2018 LESSONS LEARNED: Combination regimen with bevacizumab (BEV) and vorinostat is well tolerated in patients with recurrent glioblastoma.Treatment of recurrent glioblastoma remains challenging as this study and others attempt to improve progression-free surviv ... Full text Link to item Cite

Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma.

Journal Article Cancer Res · January 1, 2018 Median survival for glioblastoma (GBM) remains <15 months. Human cytomegalovirus (CMV) antigens have been identified in GBM but not normal brain, providing an unparalleled opportunity to subvert CMV antigens as tumor-specific immunotherapy targets. A recen ... Full text Link to item Cite

Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities.

Journal Article Cancer Res · January 1, 2018 Hotspot mutations in the isocitrate dehydrogenase 1 (IDH1) gene occur in a number of human cancers and confer a neomorphic enzyme activity that catalyzes the conversion of α-ketoglutarate (αKG) to the oncometabolite D-(2)-hydroxyglutarate (D2HG). In malign ... Full text Link to item Cite

Adjunctive perampanel for glioma-associated epilepsy.

Journal Article Epilepsy Behav Case Rep · 2018 Glioma-associated epilepsy is associated with excessive glutamate signaling. We hypothesized that perampanel, an amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor antagonist, would treat glioma-related epilepsy. We conducted ... Full text Link to item Cite

PATTERNS OF RELAPSE AFTER SUCCESSFUL COMPLETION OF INITIAL THERAPY IN PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA

Conference Neuro-Oncology · November 1, 2017 RATE-36 INTRODUCTION Primary central nervous system lymphoma (PCNSL) is a subtype of non-Hodgkin’s lymphoma that involves the brain, spinal cord or leptomeninges, without evidence of systemic disease. This rare disease accounts for ~3% of all primary centr ... Full text Link to item Cite

A cross sectional analysis from a single institution's experience of psychosocial distress and health-related quality of life in the primary brain tumor population.

Journal Article J Neurooncol · September 2017 Primary brain tumor patients experience high levels of distress. The purpose of this cross-sectional, retrospective study is to evaluate the level and different sources of psychosocial distress and how these pertain to health-related quality of life (HRQoL ... Full text Link to item Cite

A Phase II feasibility study of oral etoposide given concurrently with radiotherapy followed by dose intensive adjuvant chemotherapy for children with newly diagnosed high-risk medulloblastoma (protocol POG 9631): A report from the Children's Oncology Group.

Journal Article Pediatr Blood Cancer · June 2017 BACKGROUND: Children with high-risk medulloblastoma historically have had a poor prognosis. The Children's Oncology Group completed a Phase II study using oral etoposide given with radiotherapy followed by intensive chemotherapy. PROCEDURE: Patients enroll ... Full text Link to item Cite

Dose finding study of the intratumoral administration of the oncolytic polio/rhinovirus recombinant (PVSRIPO) against WHO grade IV malignant glioma (MG).

Conference Journal of Clinical Oncology · May 20, 2017 e13533 Background: The live attenuated oral poliovirus vaccine was modified to contain a heterologous internal ribosomal entry site stemming from human rhinovirus type 2, creating PVSRIPO. PVSRIPO recognizes CD155, an oncofetal c ... Full text Link to item Cite

Reductions in exercise behavior and tumor progression in newly diagnosed glioblastoma (GBM) patients.

Conference Journal of Clinical Oncology · May 20, 2017 e21636 Background: At diagnosis, GBM patients face the immediate challenge of significant morbidity and mortality. In this population, we have shown that better exercise behavior is an independent prognostic factor for improved s ... Full text Link to item Cite

Tumor stem cell RNA-leaded dedritic cell vaccine for recurrent glioblastoma: a phase 1 trail.

Conference Neurology · April 27, 2017 Objective: To evaluate the feasibility and safety of administering brain tumor stem cell (BTSC) mRNA-loaded dendritic cells (DC) to patients with recurrent GBM. Background: BTSC CD133+ contribute to GBM propagation and are associated with chemo-radiation ... Link to item Cite

Long-term Survival in Glioblastoma with Cytomegalovirus pp65-Targeted Vaccination.

Journal Article Clin Cancer Res · April 15, 2017 Purpose: Patients with glioblastoma have less than 15-month median survival despite surgical resection, high-dose radiation, and chemotherapy with temozolomide. We previously demonstrated that targeting cytomegalovirus pp65 using dendritic cells (DC) can e ... Full text Link to item Cite

A Phase II single-arm trial of palonosetron for the prevention of acute and delayed chemotherapy-induced nausea and vomiting in malignant glioma patients receiving multidose irinotecan in combination with bevacizumab.

Journal Article Ther Clin Risk Manag · 2017 PURPOSE: Given that the prognosis of recurrent malignant glioma (MG) remains poor, improving quality of life (QoL) through symptom management is important. Meta-analyses establishing antiemetic guidelines have demonstrated the superiority of palonosetron ( ... Full text Link to item Cite

The critical role of nonhuman primates in medical research

Journal Article Pathogens and Immunity · January 1, 2017 Full text Cite

Psychosocial distress and its effects on the health-related quality of life of primary brain tumor patients.

Journal Article CNS Oncol · October 2016 All cancer patients experience distress from the diagnosis, the effects of the disease or the treatment. Clinically significant distress decreases overall quality of life and the recognition of distress with prompt intervention is essential. The National C ... Full text Link to item Cite

Phase II study to evaluate the safety and efficacy of intravenous palonosetron (PAL) in primary malignant glioma (MG) patients receiving standard radiotherapy (RT) and concomitant temozolomide (TMZ).

Conference Support Care Cancer · October 2016 BACKGROUND: In malignant glioma (MG) patients undergoing radiation therapy (RT) with concomitant temozolomide, chemoradiation-induced nausea and vomiting (cRINV) degrades quality of life (QoL) and reduces treatment adherence, which thereby potentially comp ... Full text Link to item Cite

Patient survival on the dose escalation phase of the Oncolytic Polio/Rhinovirus Recombinant (PVSRIPO) against WHO grade IV malignant glioma (MG) clinical trial compared to historical controls.

Conference Journal of Clinical Oncology · May 20, 2016 Background: The live attenuated oral (SABIN) serotype 1 poliovirus vaccine was modified to contain a heterologous internal ribosomal entry site stemming from human rhinovirus type 2, creating PVSRIPO. PVSRIPO recognizes CD155, an oncofetal cell adhesion mo ... Full text Link to item Cite

Phase I trial of combination of antitumor immunotherapy targeted against cytomegalovirus (CMV) plus regulatory T-cell inhibition in patients with newly-diagnosed glioblastoma multiforme (GBM).

Conference Journal of Clinical Oncology · May 20, 2016 ackground: The inherent biologic specificity of immunotherapy offers the prospect of targeting neoplastic cells more precisely. Dendritic cells (DCs) are endowed with an extraordinary ability to activate CD4+ and CD8+ T-cells, and DCs loaded with antigens ... Full text Link to item Cite

Baseline cognitive function to predict survival in patients with glioblastoma.

Conference Journal of Clinical Oncology · May 20, 2016 Background: Overall survival of patients with glioblastoma (GBM) remains dismal with range from 12-14 months. In addition to the oncologic burden that these patients face during the disease trajectory, there are demonstrable neurologic and cognitive challe ... Full text Link to item Cite

The Duke glioma handbook: Pathology, diagnosis, and management

Book · March 31, 2016 The management of patients with a glioma is challenging and best achieved by a team approach encompassing a combination of chemotherapy, radiotherapy, immunotherapy, and surgical excision in a specialist Cancer Center - the balance of treatment depending o ... Full text Cite

Chemotherapy for gliomas

Chapter · March 31, 2016 Full text Cite

Vaccine Therapy, Oncolytic Viruses, and Gliomas.

Journal Article Oncology (Williston Park) · March 2016 After years of active research and refinement, vaccine therapy and oncolytic viruses are becoming part of the arsenal in the treatment of gliomas. In contrast to standard treatment with radiation therapy and chemotherapy, vaccines are more specific to the ... Link to item Cite

Phosphorylation of Glutathione S-Transferase P1 (GSTP1) by Epidermal Growth Factor Receptor (EGFR) Promotes Formation of the GSTP1-c-Jun N-terminal kinase (JNK) Complex and Suppresses JNK Downstream Signaling and Apoptosis in Brain Tumor Cells.

Journal Article J Biol Chem · December 25, 2015 Under normal physiologic conditions, the glutathione S-transferase P1 (GSTP1) protein exists intracellularly as a dimer in reversible equilibrium with its monomeric subunits. In the latter form, GSTP1 binds to the mitogen-activated protein kinase, JNK, and ... Full text Link to item Cite

Phase II Trial of Upfront Bevacizumab, Irinotecan, and Temozolomide for Unresectable Glioblastoma.

Journal Article Oncologist · July 2015 LESSONS LEARNED: Trials focusing on unresectable multifocal glioblastoma are needed because of the extremely poor prognosis and challenges in receiving standard therapy, such as concurrent radiation and chemotherapy.Developing a strategy to chemically debu ... Full text Link to item Cite

Secondary cancers in long-term survivors of primary glioblastoma.

Conference JOURNAL OF CLINICAL ONCOLOGY · May 20, 2015 Link to item Cite

Phase II study of bevacizumab and vorinostat for recurrent glioblastoma.

Conference Journal of Clinical Oncology · May 20, 2015 Full text Cite

Phase II study of bevacizumab and vorinostat for recurrent glioblastoma.

Conference Journal of Clinical Oncology · May 20, 2015 2034 ... Link to item Cite

Severe adverse immunologic reaction in a patient with glioblastoma receiving autologous dendritic cell vaccines combined with GM-CSF and dose-intensified temozolomide.

Journal Article Cancer Immunol Res · April 2015 Therapeutic vaccination of patients with cancer-targeting tumor-associated antigens is a promising strategy for the specific eradication of invasive malignancies with minimal toxicity to normal tissues. However, as increasingly potent modalities for stimul ... Full text Link to item Cite

Prognostic marker analysis in pediatric intracranial ependymomas.

Journal Article J Neurooncol · April 2015 Histologic grading methods dependent upon H&E staining review have not been shown to reliably predict survival in children with intracranial ependymomas due to the subjectivity of the analytical methods. We hypothesized that the immunohistochemical detecti ... Full text Link to item Cite

Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients.

Journal Article Nature · March 19, 2015 After stimulation, dendritic cells (DCs) mature and migrate to draining lymph nodes to induce immune responses. As such, autologous DCs generated ex vivo have been pulsed with tumour antigens and injected back into patients as immunotherapy. While DC vacci ... Full text Open Access Link to item Cite

Novel role of hematopoietic stem cells in immunologic rejection of malignant gliomas.

Journal Article Oncoimmunology · March 2015 Adoptive cellular therapy (ACT) after lymphodepletive conditioning can induce dramatic clinical responses, but this approach has been largely limited to melanoma due to a lack of reliable methods for expanding tumor-specific lymphocytes from the majority o ... Full text Link to item Cite

Impact of health-related quality of life and fatigue on survival of recurrent high-grade glioma patients.

Journal Article J Neurooncol · December 2014 Quality of life (QoL) impairment and fatigue are frequently experienced during treatment for recurrent high-grade glioma (HGG). Fatigue and QoL impairments can be due to primary neurological dysfunction, cytotoxic treatments, mood disturbances, and support ... Full text Link to item Cite

Profiling Hsp90 differential expression and the molecular effects of the Hsp90 inhibitor IPI-504 in high-grade glioma models.

Journal Article J Neurooncol · December 2014 Retaspimycin hydrochloride (IPI-504), an Hsp90 (heat shock protein 90) inhibitor, has shown activity in multiple preclinical cancer models, such as lung, breast and ovarian cancers. However, its biological effects in gliomas and normal brain derived cellul ... Full text Link to item Cite

Oncolytic polio virotherapy of cancer.

Journal Article Cancer · November 1, 2014 Recently, the century-old idea of targeting cancer with viruses (oncolytic viruses) has come of age, and promise has been documented in early stage and several late-stage clinical trials in a variety of cancers. Although originally prized for their direct ... Full text Link to item Cite

Adherence to antiemetic guidelines in patients with malignant glioma: a quality improvement project to translate evidence into practice.

Journal Article Support Care Cancer · July 2014 PURPOSE: A quality improvement project was implemented to improve adherence to evidence-based antiemetic guidelines for malignant glioma patients treated with moderately emetic chemotherapy (MEC). Poorly controlled chemotherapy-induced nausea and vomiting ... Full text Link to item Cite

Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.

Journal Article Nat Genet · July 2014 Gliomas arising in the brainstem and thalamus are devastating tumors that are difficult to surgically resect. To determine the genetic and epigenetic landscape of these tumors, we performed exomic sequencing of 14 brainstem gliomas (BSGs) and 12 thalamic g ... Full text Link to item Cite

Oncolytic polio/rhinovirus recombinant (pvsripo) in recurrent glioblastoma (gbm): first phase I clinical trial evaluating the intratumoral administration.

Journal Article Neuro Oncol · July 2014 PVSRIPO is the live attenuated, oral (SABIN) serotype 1 poliovirus vaccine containing a heterologous internal ribosomal entry site stemming from human rhinovirus type 2. PVSRIPO recognizes nectin-like molecule-5, an oncofetal cell adhesion molecule and tum ... Full text Link to item Cite

Identification and preliminary treatment data of xenografts representing tcga-defined subtypes.

Journal Article Neuro Oncol · July 2014 The Cancer Genome Atlas (TCGA) Network recently catalogued recurrent genomic abnormalities in glioblastoma (GBM). This genomic profiling lead to the molecular classification of GBMs into four subtypes: Proneural, Neural, Classical and Mesenchymal. The impo ... Full text Link to item Cite

Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas.

Journal Article Oncotarget · March 30, 2014 Frequent mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) and the promoter of telomerase reverse transcriptase (TERT) represent two significant discoveries in glioma genomics. Understanding the degree to which these two mutations co-occur or o ... Full text Open Access Link to item Cite

The genetic landscape of anaplastic astrocytoma.

Journal Article Oncotarget · March 30, 2014 Anaplastic astrocytoma WHO grade III (A3) is a lethal brain tumor that often occurs in middle aged patients. Clinically, it is challenging to distinguish A3 from glioblastoma multiforme (GBM) WHO grade IV. To reveal the genetic landscape of this tumor type ... Full text Link to item Cite

Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas

Journal Article Nature Genetics · January 1, 2014 Gliomas arising in the brainstem and thalamus are devastating tumors that are difficult to surgically resect. To determine the genetic and epigenetic landscape of these tumors, we performed exomic sequencing of 14 brainstem gliomas (BSGs) and 12 thalamic g ... Full text Cite

Efficacy of bevacizumab plus irinotecan in children with recurrent low-grade gliomas--a Pediatric Brain Tumor Consortium study.

Journal Article Neuro Oncol · January 2014 BACKGROUND: A phase II study of bevacizumab (BVZ) plus irinotecan (CPT-11) was conducted in children with recurrent low-grade glioma to measure sustained response and/or stable disease lasting ≥6 months and progression-free survival. METHODS: Thirty-five e ... Full text Link to item Cite

Bevacizumab (BVZ)-associated toxicities in children with recurrent central nervous system tumors treated with BVZ and irinotecan (CPT-11): a Pediatric Brain Tumor Consortium Study (PBTC-022).

Conference Cancer · December 1, 2013 BACKGROUND: The incidence and spectrum of acute toxicities related to the use of bevacizumab (BVZ)-containing regimens in children are largely unknown. This report describes the adverse events in a recently completed large phase 2 trial of BVZ plus irinote ... Full text Link to item Cite

Proteasome inhibition with bortezomib induces cell death in GBM stem-like cells and temozolomide-resistant glioma cell lines, but stimulates GBM stem-like cells' VEGF production and angiogenesis.

Journal Article J Neurosurg · December 2013 OBJECT: Recurrent malignant gliomas have inherent resistance to traditional chemotherapy. Novel therapies target specific molecular mechanisms involved in abnormal signaling and resistance to apoptosis. The proteasome is a key regulator of multiple cellula ... Full text Link to item Cite

High-risk medulloblastoma: a pediatric oncology group randomized trial of chemotherapy before or after radiation therapy (POG 9031).

Journal Article J Clin Oncol · August 10, 2013 PURPOSE: To compare event-free survival (EFS) in children with high-risk medulloblastoma randomly assigned to receive either chemotherapy before radiation or chemotherapy after radiation. PATIENTS AND METHODS: One hundred twelve patients were randomly assi ... Full text Link to item Cite

Concurrent stereotactic radiosurgery and bevacizumab in recurrent malignant gliomas: a prospective trial.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 2013 PURPOSE: Virtually all patients with malignant glioma (MG) eventually recur. This study evaluates the safety of concurrent stereotactic radiosurgery (SRS) and bevacizumab (BVZ), an antiangiogenic agent, in treatment of recurrent MG. METHODS AND MATERIALS: ... Full text Link to item Cite

O6-methylguanine-DNA methyltransferase (MGMT) immunohistochemistry as a predictor of resistance to temozolomide in primary CNS lymphoma.

Journal Article J Neurooncol · August 2013 Temozolomide, an alkylating agent, has shown promise in treating primary central nervous system lymphoma (PCNSL). The enzyme O(6)-methylguanine-DNA methyltransferase (MGMT) repairs alkylating damage, such as that induced by temozolomide. We hypothesized th ... Full text Link to item Cite

Abstract 2079: Antitumoral activity of INC280 against adult glioblastoma brain tumors xenografts.

Conference Cancer Research · April 15, 2013 AbstractINTRODUCTION: INC280 is an oral, highly selective c-Met receptor tyrosine kinase inhibitor. The hepatocyte growth factor (HGF)-c-Met pathway is one of the most frequently dysregulated pathways in hum ... Full text Cite

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.

Journal Article Proc Natl Acad Sci U S A · April 9, 2013 Malignant cells, like all actively growing cells, must maintain their telomeres, but genetic mechanisms responsible for telomere maintenance in tumors have only recently been discovered. In particular, mutations of the telomere binding proteins alpha thala ... Full text Link to item Cite

Phase II trial of upfront bevacizumab and temozolomide for unresectable or multifocal glioblastoma.

Journal Article Cancer Med · April 2013 Patients with unresectable glioblastomas have a poor prognosis, with median survival of 6-10 months. We conducted a phase II trial of upfront 5-day temozolomide (TMZ) and bevacizumab (BV) in patients with newly diagnosed unresectable or multifocal glioblas ... Full text Open Access Link to item Cite

Mibefradil, a novel therapy for glioblastoma multiforme: cell cycle synchronization and interlaced therapy in a murine model.

Journal Article J Neurooncol · January 2013 Glioblastoma multiforme (GBM) is a devastating disease with a dismal prognosis and a very limited response to treatment. The current standard of care for GBM usually consists of surgery, radiation and chemotherapy with the alkylating agent temozolomide, al ... Full text Link to item Cite

Lack of efficacy of bevacizumab + irinotecan in cases of pediatric recurrent ependymoma--a Pediatric Brain Tumor Consortium study.

Journal Article Neuro Oncol · November 2012 A phase II study of bevacizumab (BVZ) plus irinotecan (CPT-11) was conducted in cases of pediatric recurrent ependymoma (EPN) to estimate sustained objective response rate and progression-free survival (PFS). Eligible patients received 2 doses of single-ag ... Full text Link to item Cite

Bevacizumab continuation beyond initial bevacizumab progression among recurrent glioblastoma patients.

Journal Article Br J Cancer · October 23, 2012 BACKGROUND: Bevacizumab improves outcome for most recurrent glioblastoma patients, but the duration of benefit is limited and survival after initial bevacizumab progression is poor. We evaluated bevacizumab continuation beyond initial progression among rec ... Full text Open Access Link to item Cite

Mismatch repair deficiency: a temozolomide resistance factor in medulloblastoma cell lines that is uncommon in primary medulloblastoma tumours.

Journal Article Br J Cancer · October 9, 2012 BACKGROUND: Tumours are responsive to temozolomide (TMZ) if they are deficient in O(6)-methylguanine-DNA methyltransferase (MGMT), and mismatch repair (MMR) proficient. METHODS: The effect of TMZ on medulloblastoma (MB) cell killing was analysed with clono ... Full text Link to item Cite

Phase II study of Gleevec plus hydroxyurea in adults with progressive or recurrent low-grade glioma.

Journal Article Cancer · October 1, 2012 BACKGROUND: We evaluated the efficacy of imatinib plus hydroxyurea in patients with progressive/recurrent low-grade glioma. METHODS: A total of 64 patients with recurrent/progressive low-grade glioma were enrolled in this single-center study that stratifie ... Full text Link to item Cite

Bevacizumab therapy for adults with recurrent/progressive meningioma: a retrospective series.

Journal Article J Neurooncol · August 2012 Intracranial meningiomas are often indolent tumors which typically grow over years to decades. Nonetheless, meningiomas that progress after maximum safe resection and radiation therapy pose a significant therapeutic challenge and effective therapies have y ... Full text Link to item Cite

Phase 1 trial of dasatinib plus erlotinib in adults with recurrent malignant glioma.

Journal Article J Neurooncol · July 2012 To determine the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of dasatinib, an inhibitor of the Src family kinase proteins, with erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, among recurrent malignant glioma pat ... Full text Link to item Cite

Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas.

Journal Article Oncotarget · July 2012 Mutations in the critical chromatin modifier ATRX and mutations in CIC and FUBP1, which are potent regulators of cell growth, have been discovered in specific subtypes of gliomas, the most common type of primary malignant brain tumors. However, the frequen ... Full text Open Access Link to item Cite

Adjuvant PCV chemo hikes oligodendroglioma survival: Commentary

Journal Article Oncology Report · July 1, 2012 Cite

Phase I study of AEE788, a novel multitarget inhibitor of ErbB- and VEGF-receptor-family tyrosine kinases, in recurrent glioblastoma patients.

Journal Article Cancer Chemother Pharmacol · June 2012 PURPOSE: Vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) play a significant role in glioblastoma angiogenesis and proliferation, making tyrosine kinase (TK) receptors logical targets for treatment. We evaluat ... Full text Link to item Cite

Abstract LB-76: Mibefradil, a novel therapy for glioblastoma: An interlaced therapy approach

Journal Article Cancer Research · April 15, 2012 AbstractINTRODUCTION: Finding new ways to improve the efficacy and/or overcome resistance to conventional chemotherapy for brain tumor patients is an ongoing research paradigm. Interlaced TherapyTM is a syne ... Full text Cite

A change in the apparent diffusion coefficient after treatment with bevacizumab is associated with decreased survival in patients with recurrent glioblastoma multiforme.

Journal Article Br J Radiol · April 2012 OBJECTIVES: The aim of this study was to determine the prognostic significance of changes in parameters derived from diffusion tensor imaging (DTI) that occur in response to treatment with bevacizumab and irinotecan in patients with recurrent glioblastoma ... Full text Link to item Cite

Safety and efficacy of stereotactic radiosurgery and adjuvant bevacizumab in patients with recurrent malignant gliomas.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2012 PURPOSE: Patients with recurrent malignant gliomas treated with stereotactic radiosurgery (SRS) and multiagent systemic therapies were reviewed to determine the effects of patient- and treatment-related factors on survival and toxicity. METHODS AND MATERIA ... Full text Link to item Cite

Phase II study of carboplatin, irinotecan, and bevacizumab for bevacizumab naïve, recurrent glioblastoma.

Journal Article J Neurooncol · March 2012 We evaluated the efficacy of carboplatin, irinotecan, and bevacizumab among bevacizumab-naïve, recurrent glioblastoma (GBM) patients in a phase 2, open-label, single arm trial. Forty eligible patients received carboplatin (area under the plasma curve [AUC] ... Full text Link to item Cite

Outcome after bevacizumab clinical trial therapy among recurrent grade III malignant glioma patients.

Journal Article J Neurooncol · March 2012 Although outcome following bevacizumab among recurrent grade IV malignant glioma patients is documented as poor by several analyses, outcome for recurrent grade III patients following bevacizumab therapy has not been specifically evaluated. We performed a ... Full text Link to item Cite

Bevacizumab and daily temozolomide for recurrent glioblastoma.

Journal Article Cancer · March 1, 2012 BACKGROUND: The authors performed a phase 2 trial of combined protracted daily temozolomide and biweekly bevacizumab for patients with recurrent glioblastoma who had previously received radiation therapy and temozolomide. METHODS: There was no limit on the ... Full text Link to item Cite

Addition of bevacizumab to standard radiation therapy and daily temozolomide is associated with minimal toxicity in newly diagnosed glioblastoma multiforme.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2012 PURPOSE: To determine the safety of the addition of bevacizumab to standard radiation therapy and daily temozolomide for newly diagnosed glioblastoma multiforme (GBM). METHODS AND MATERIALS: A total of 125 patients with newly diagnosed GBM were enrolled in ... Full text Link to item Cite

A pilot study of IL-2Rα blockade during lymphopenia depletes regulatory T-cells and correlates with enhanced immunity in patients with glioblastoma.

Journal Article PLoS One · 2012 BACKGROUND: Preclinical studies in mice have demonstrated that the prophylactic depletion of immunosuppressive regulatory T-cells (T(Regs)) through targeting the high affinity interleukin-2 (IL-2) receptor (IL-2Rα/CD25) can enhance anti-tumor immunotherapy ... Full text Open Access Link to item Cite

Phase II study of Gleevec® plus hydroxyurea (HU) in adults with progressive or recurrent meningioma.

Journal Article J Neurooncol · January 2012 We prospectively evaluated the efficacy and safety of imatinib plus hydroxyurea in patients with progressive/recurrent meningioma. A total of 21 patients with progressive/recurrent meningioma were enrolled in this dual center, single-arm, phase II trial. A ... Full text Link to item Cite

Phase I study of sunitinib and irinotecan for patients with recurrent malignant glioma.

Journal Article J Neurooncol · December 2011 We determined the maximum tolerated dose (MTD) and dose-limiting toxicities (DLT) of the oral vascular endothelial growth factor receptor (VEGFR) inhibitor, sunitinib, when administered with irinotecan among recurrent malignant glioma (MG) patients. For ea ... Full text Link to item Cite

Phase 2 study of carboplatin, irinotecan, and bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy.

Journal Article Cancer · December 1, 2011 BACKGROUND: The efficacy of carboplatin, irinotecan, and bevacizumab among recurrent glioblastoma (GBM) patients after prior progression on bevacizumab therapy in a phase 2, open-label, single-arm trial was evaluated. METHODS: Eligible patients received ca ... Full text Link to item Cite

A phase I trial of the farnesyl transferase inhibitor, SCH 66336, with temozolomide for patients with malignant glioma.

Journal Article J Neurooncol · December 2011 We conducted a phase I clinical trial of the combination of SCH 66336 with temozolomide administered on the standard 5-day dosing schedule. The primary objective was to determine the maximum tolerated dose and dose limiting toxicity (DLT) of twice daily SC ... Full text Link to item Cite

Everolimus tablets for patients with subependymal giant cell astrocytoma.

Journal Article Expert Opin Pharmacother · October 2011 INTRODUCTION: Better understanding of aberrantly active molecular pathways in tumors offers potential to develop more specific and less toxic therapies. Abnormal mammalian target of rapamycin (mTOR) complex signaling and defects in TSC1 and TSC2 have been ... Full text Link to item Cite

Monoclonal antibody blockade of IL-2 receptor α during lymphopenia selectively depletes regulatory T cells in mice and humans.

Journal Article Blood · September 15, 2011 Lymphodepletion augments adoptive cell transfer during antitumor immunotherapy, producing dramatic clinical responses in patients with malignant melanoma. We report that the lymphopenia induced by the chemotherapeutic agent temozolomide (TMZ) enhances vacc ... Full text Link to item Cite

Exercise behavior, functional capacity, and survival in adults with malignant recurrent glioma.

Journal Article J Clin Oncol · July 20, 2011 PURPOSE: Identifying strong markers of prognosis are critical to optimize treatment and survival outcomes in patients with malignant recurrent glioma. We investigated the prognostic significance of exercise behavior and functional capacity in this populati ... Full text Link to item Cite

The addition of bevacizumab to standard radiation therapy and temozolomide followed by bevacizumab, temozolomide, and irinotecan for newly diagnosed glioblastoma.

Journal Article Clin Cancer Res · June 15, 2011 PURPOSE: To determine if the addition of bevacizumab to radiation therapy and temozolomide, followed by bevacizumab, temozolomide, and irinotecan, for newly diagnosed glioblastoma patients is safe and effective. EXPERIMENTAL DESIGN: A total of 75 patients ... Full text Link to item Cite

Phase II study of metronomic chemotherapy with bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy.

Journal Article J Neurooncol · June 2011 We evaluated the efficacy of metronomic etoposide or temozolomide administered with bevacizumab among recurrent glioblastoma (GBM) patients who progressed on prior bevacizumab therapy in a phase 2, open-label, two-arm trial. Twenty-three patients received ... Full text Link to item Cite

Neurocognitive function in patients with recurrent glioblastoma treated with bevacizumab.

Journal Article Neuro Oncol · June 2011 Neurocognitive decline is a frequent adverse effect of glioblastoma. Antitumor therapies that are efficacious, as measured by traditional endpoints such as objective response (OR) and progression-free survival (PFS), and have beneficial effects on neurocog ... Full text Link to item Cite

Bevacizumab (BV) continuation following BV progression: Meta-analysis of five consecutive recurrent glioblastoma (GBM) trials.

Journal Article J Clin Oncol · May 20, 2011 2030 Background: Although BV benefits most recurrent GBM patients, the duration of benefit is limited and subsequent survival after BV progression is poor due to lack of effective therapeutic options. METHODS: We performed a meta-analysis of five consecuti ... Link to item Cite

Venous thromboembolic complications in patients with malignant glioma treated on a bevacizumab clinical trial.

Journal Article J Clin Oncol · May 20, 2011 9090 Background: Although the prognosis for malignant glioma remains poor, the introduction of bevacizumab has improved survival for patients with this devastating illness. Bevacizumab is a humanized monoclonal antibody to vascular endothelial growth facto ... Link to item Cite

Upfront bevacizumab with temozolomide or with temozolomide and irinotecan for unresectable or multifocal glioblastoma.

Journal Article J Clin Oncol · May 20, 2011 2055 Background: Patients with unresectable or multifocal glioblastomas (GBs) have a poor prognosis with median survival of 6-10 months. Given the angiogenic phenotype of GB, we conducted two phase II trials of upfront 5-day temozolomide (TMZ) and Bevacizu ... Link to item Cite

Phase II clinical trial of bortezomib and bevacizumab combination in recurrent glioblastoma.

Journal Article J Clin Oncol · May 20, 2011 2056 Background: The only approved 2nd-line treatment for glioblastoma is Bevacizumab (Avastin), with estimated 6-month progression-free survival (PFS) rate of 42.6% and overall survival (OS) of 9.2 months. Laboratory data show Bortezomib (Velcade) is an e ... Link to item Cite

A pharmacokinetic (PK) study of AC480 administered twice daily in patients with surgically resectable, recurrent malignant glioma (MG) not on enzyme-inducing antiepileptic drug (EIAED).

Journal Article J Clin Oncol · May 20, 2011 2070 Background: AC480 is a novel oral tyrosine kinase inhibitor of the human epidermal growth factor receptor family, especially EGFR and HER2. EGFR is an important therapeutic target in MG. We performed a pilot study to evaluate the tumor and plasma PK o ... Link to item Cite

Bevacizumab, temozolomide, and radiation therapy followed by bevacizumab, temozolomide, and oral topotecan for newly-diagnosed glioblastoma multiforme (GBM).

Journal Article J Clin Oncol · May 20, 2011 2098 Background: The prognosis for newly-diagnosed GBM remains poor. Adding temozolomide to radiation therapy improved the median event-free survival (EFS) to 6.9 months and median overall survival to 14.6 months. The five year survival remains < 10%. GBM' ... Link to item Cite

A review of VEGF/VEGFR-targeted therapeutics for recurrent glioblastoma.

Journal Article J Natl Compr Canc Netw · April 2011 Glioblastoma, the most common primary malignant brain tumor among adults, is a highly angiogenic and deadly tumor. Angiogenesis in glioblastoma, driven by hypoxia-dependent and independent mechanisms, is primarily mediated by vascular endothelial growth fa ... Full text Link to item Cite

Prognostic significance of parameters derived from co-registered 18F-fluorodeoxyglucose PET and contrast-enhanced MRI in patients with high-grade glioma.

Journal Article Br J Radiol · April 2011 OBJECTIVE: The aim of this study was to determine the prognostic significance of the volume and intensity of abnormal (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) accumulation within areas of contrast enhancement on post-therapeutic volu ... Full text Link to item Cite

Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma.

Journal Article Neuro Oncol · March 2011 Epidermal growth factor receptor variant III (EGFRvIII) is a tumor-specific mutation widely expressed in glioblastoma multiforme (GBM) and other neoplasms, but absent from normal tissues. Immunotherapeutic targeting of EGFRvIII could eliminate neoplastic c ... Full text Link to item Cite

The genetic landscape of the childhood cancer medulloblastoma.

Journal Article Science · January 28, 2011 Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the genetic alterations in this tumor type, we searched for copy number alterations using high-density microarrays and sequenced all known protein-coding genes and micro ... Full text Link to item Cite

Effect of CYP3A-inducing anti-epileptics on sorafenib exposure: results of a phase II study of sorafenib plus daily temozolomide in adults with recurrent glioblastoma.

Journal Article J Neurooncol · January 2011 Sorafenib, an oral VEGFR-2, Raf, PDGFR, c-KIT and Flt-3 inhibitor, is active against renal cell and hepatocellular carcinomas, and has recently demonstrated promising activity for lung and breast cancers. In addition, various protracted temozolomide dosing ... Full text Link to item Cite

Ulceration of Striae distensae in high-grade glioma patients on concurrent systemic corticosteroid and bevacizumab therapy.

Journal Article J Neurooncol · January 2011 Striae distensae (stretch marks) are a common complication seen in patients on chronic corticosteroid therapy. Under certain circumstances, primary brain tumor patients require chronic corticosteroid therapy and can suffer from striae distensae. Bevacizuma ... Full text Link to item Cite

Response as a predictor of survival in patients with recurrent glioblastoma treated with bevacizumab.

Journal Article Neuro Oncol · January 2011 Development of effective therapies for recurrent glioblastoma multiforme (GBM) and reliable, timely evaluation of their benefit are needed. Understanding the relationship between objective response (OR) and survival is important for determining whether OR ... Full text Link to item Cite

Phase II trial of bevacizumab and erlotinib in patients with recurrent malignant glioma.

Journal Article Neuro Oncol · December 2010 Vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) signaling are established contributors to malignant glioma (MG) biology. We, therefore, evaluated bevacizumab, a humanized anti-VEGF monoclonal antibody, in combination w ... Full text Link to item Cite

Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling

Journal Article Cellular Therapy and Transplantation · December 1, 2010 The clinical manifestations of Fanconi's anemia, an autosomal recessive disorder, include progressive pancyto-penia, a predisposition to neoplasia, and nonhematopoietic developmental anomalies [1-3]. Hypersensitivity to the clastogenic effect of DNA-cross- ... Full text Open Access Cite

Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma.

Journal Article J Clin Oncol · November 1, 2010 PURPOSE: Immunologic targeting of tumor-specific gene mutations may allow precise eradication of neoplastic cells without toxicity. Epidermal growth factor receptor variant III (EGFRvIII) is a constitutively activated and immunogenic mutation not expressed ... Full text Link to item Cite

Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells.

Journal Article J Biomed Res · November 2010 Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor in adults. Current therapy includes surgery, radiation and chemotherapy with temozolomide (TMZ). Major determinants of clinical response to TMZ include methylation status of the O6-me ... Full text Link to item Cite

Poor drug distribution as a possible explanation for the results of the PRECISE trial.

Journal Article J Neurosurg · August 2010 OBJECT: Convection-enhanced delivery (CED) is a novel intracerebral drug delivery technique with considerable promise for delivering therapeutic agents throughout the CNS. Despite this promise, Phase III clinical trials employing CED have failed to meet cl ... Full text Link to item Cite

Inhibition of poly(ADP-ribose) polymerase enhances the effect of chemotherapy in an animal model of regional therapy for the treatment of advanced extremity malignant melanoma.

Journal Article Ann Surg Oncol · August 2010 BACKGROUND: Poly(ADP-ribose) polymerase (PARP) is an important regulator of programmed cell death in response to alkylating agents such as temozolomide (TMZ). The goal of this study was to determine if a systemically administered PARP-inhibitor (INO-1001) ... Full text Link to item Cite

Bevacizumab fails to treat temporal paraganglioma: discussion and case illustration.

Journal Article J Neurooncol · July 2010 Temporal paragangliomas are highly vascular tumors treated primarily by surgical resection. However, surgery to remove these tumors is associated with significant morbidity, including cranial nerve dysfunction. Interestingly, these tumors have been shown t ... Full text Link to item Cite

Bevacizumab-irinotecan data hold up in recurrent GBM: Comment

Journal Article Oncology Report · July 1, 2010 Cite

Lack of efficacy of bevacizumab plus irinotecan in children with recurrent malignant glioma and diffuse brainstem glioma: a Pediatric Brain Tumor Consortium study.

Journal Article J Clin Oncol · June 20, 2010 PURPOSE: A phase II study of bevacizumab (BVZ) plus irinotecan (CPT-11) was conducted in children with recurrent malignant glioma (MG) and intrinsic brainstem glioma (BSG). PATIENTS AND METHODS: Eligible patients received two doses of BVZ intravenously (10 ... Full text Link to item Cite

Long-term survival from the initial trial of bevacizumab and irinotecan.

Journal Article JOURNAL OF CLINICAL ONCOLOGY · May 20, 2010 Link to item Cite

Reply to W. Wick et al

Journal Article Journal of Clinical Oncology · April 20, 2010 Full text Cite

Gene expression signatures as a guide to treatment strategies for in-transit metastatic melanoma.

Journal Article Mol Cancer Ther · April 2010 In-transit metastatic melanoma, which typically presents as multifocal lesions, provides a unique setting to evaluate the utility of gene signatures for defining optimal regional therapeutic strategies and assessing the efficacy of treatment. The goal of t ... Full text Link to item Cite

Quantitative assessment of cardiorespiratory fitness, skeletal muscle function, and body composition in adults with primary malignant glioma.

Journal Article Cancer · February 1, 2010 BACKGROUND: The study was undertaken to evaluate cardiorespiratory fitness, skeletal muscle function, and body composition of patients with newly diagnosed and untreated, postsurgical primary malignant glioma. METHODS: By using a cross-sectional design, pa ... Full text Link to item Cite

Phase 2 trial of erlotinib plus sirolimus in adults with recurrent glioblastoma.

Journal Article J Neurooncol · January 2010 We evaluated the anti-tumor activity and safety of erlotinib, a receptor tyrosine kinase inhibitor of the epidermal growth factor receptor, plus sirolimus, an inhibitor of the mammalian target of rapamycin, among patients with recurrent glioblastoma (GBM) ... Full text Link to item Cite

Changes in functional performance measures in adults undergoing chemoradiation for primary malignant glioma: a feasibility study.

Journal Article Oncologist · 2010 PURPOSE: To investigate the feasibility of longitudinal assessment of functional performance measures in newly diagnosed postsurgical malignant glioma patients. METHODS: Patients with histologically confirmed, clinically stable, postsurgical, and previousl ... Full text Link to item Cite

Corticosteroid use in patients with glioblastoma at first or second relapse treated with bevacizumab in the BRAIN study.

Journal Article Oncologist · 2010 BACKGROUND: Vascular endothelial growth factor inhibitors have corticosteroid-sparing effects in patients with high-grade gliomas. We assessed corticosteroid use in patients with recurrent glioblastoma treated with bevacizumab (BEV) in the BRAIN study (J C ... Full text Link to item Cite

Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study.

Journal Article Br J Cancer · December 15, 2009 BACKGROUND: We evaluated bevacizumab with metronomic etoposide among recurrent malignant glioma patients in a phase 2, open-label trial. METHODS: A total of 59 patients, including 27 with glioblastoma (GBM) and 32 with grade 3 malignant glioma, received 10 ... Full text Open Access Link to item Cite

Phase II trial of temozolomide (TMZ) plus irinotecan (CPT-11) in adults with newly diagnosed glioblastoma multiforme before radiotherapy.

Journal Article J Neurooncol · December 2009 This phase II trial evaluated efficacy and safety of temozolomide (TMZ) in combination with irinotecan (CPT-11) before radiotherapy in patients with newly diagnosed glioblastoma multiforme (GBM). Prior to radiotherapy, patients were treated with a maximum ... Full text Link to item Cite

Tinzaparin prophylaxis against venous thromboembolic complications in brain tumor patients.

Journal Article J Neurooncol · October 2009 The purpose of this study was to determine the safety of tinzaparin for deep vein thrombosis prophylaxis in newly diagnosed grade III-IV malignant glioma patients. Patients were initiated on daily tinzaparin at a fixed dose of 4,500 IU subcutaneously betwe ... Full text Link to item Cite

A sphingosine kinase inhibitor induces cell death in temozolomide resistant glioblastoma cells.

Journal Article Cancer Chemother Pharmacol · October 2009 PURPOSE: Sphingosine kinase is an oncogene that is up-regulated in several solid tumors. The product of the sphingosine kinase activity, sphingosine-1-phosphate is a potent mitogen involved in diverse cell processes such as cell survival and migration. Cur ... Full text Link to item Cite

An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme.

Journal Article Mol Cancer Ther · October 2009 Conventional therapies for glioblastoma multiforme (GBM) fail to target tumor cells exclusively, such that their efficacy is ultimately limited by nonspecific toxicity. Immunologic targeting of tumor-specific gene mutations, however, may allow more precise ... Full text Link to item Cite

Phase I trial of temozolomide plus O6-benzylguanine 5-day regimen with recurrent malignant glioma.

Journal Article Neuro Oncol · October 2009 This phase I clinical trial conducted with patients who had recurrent or progressive malignant glioma (MG) was designed to determine the maximum tolerated dose (MTD) and toxicity of three different 5-day dosing regimens of temozolomide (TMZ) in combination ... Full text Link to item Cite

Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma.

Journal Article J Clin Oncol · October 1, 2009 PURPOSE: We evaluated the efficacy of bevacizumab, alone and in combination with irinotecan, in patients with recurrent glioblastoma in a phase II, multicenter, open-label, noncomparative trial. PATIENTS AND METHODS: One hundred sixty-seven patients were r ... Full text Link to item Cite

Bevacizumab, chemotherapy, and RT delay progression: Commentary

Journal Article Oncology Report · September 1, 2009 Cite

Overall survival of newly diagnosed glioblastoma patients receiving carmustine wafers followed by radiation and concurrent temozolomide plus rotational multiagent chemotherapy.

Journal Article Cancer · August 1, 2009 BACKGROUND: Glioblastoma multiforme (GBM), the most lethal type of brain tumor, has a 1-year median survival. The effect of carmustine wafers on the survival of newly diagnosed GBM patients treated with radiotherapy (RT) and concurrent temozolomide (TMZ) p ... Full text Link to item Cite

Assessment of physical functioning in recurrent glioma: preliminary comparison of performance status to functional capacity testing.

Journal Article J Neurooncol · August 2009 BACKGROUND: Performance status (PS) scoring systems are tools of immense clinical importance in the management of patients with malignant disease but these tools are subjective and do not provide an objective evaluation of physical functioning. We conducte ... Full text Link to item Cite

Phase 1 trial of temozolomide plus irinotecan plus O6-benzylguanine in adults with recurrent malignant glioma.

Journal Article Cancer · July 1, 2009 BACKGROUND: The current study was a phase 1 clinical trial conducted with patients who had recurrent or progressive malignant glioma (MG). The trial was designed to determine the maximum tolerated dose (MTD) and toxicity of irinotecan (CPT-11) when adminis ... Full text Link to item Cite

Tyrosine phosphorylation of the human glutathione S-transferase P1 by epidermal growth factor receptor.

Journal Article J Biol Chem · June 19, 2009 Epidermal growth factor receptor (EGFR) gene amplification, mutations, and/or aberrant activation are frequent abnormalities in malignant gliomas and other human cancers and have been associated with an aggressive clinical course and a poor therapeutic out ... Full text Link to item Cite

Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway.

Journal Article Mol Pharmacol · June 2009 The presence of DNA damage initiates signaling through the ataxia-telangiectasia mutated kinase (ATM) and the ATM- and the Rad3-related kinase (ATR), which phosphorylate, thus activating, the checkpoint kinases (Chk) 1 and 2, which leads to cell cycle arre ... Full text Link to item Cite

Phase I study of vandetanib, imatinib mesylate, and hydroxyurea for recurrent malignant glioma.

Journal Article J Clin Oncol · May 20, 2009 e13007 Background: Malignant glioma (MG), an incurable primary CNS tumor, is characterized by frequent aberrant activation of EGFR, VEGFR, and PDGFR. This study will determine the MTD and DLT of vandetanib (V), a once-daily, oral selective inhibitor of VEG ... Link to item Cite

A phase I study of sunitinib plus irinotecan in the treatment of patients with recurrent malignant glioma.

Journal Article J Clin Oncol · May 20, 2009 e13024 Background: Malignant glioma (MG), an incurable primary CNS tumor, are highly angiogenic due to overexpression of VEGF/VEGFR. The current study was designed to determine the MTD and DLT of sunitinib (S), a once-daily, oral selective inhibitor of VEG ... Link to item Cite

Effect of daclizumab on TReg counts and EGFRvIII-specific immune responses in GBM.

Journal Article J Clin Oncol · May 20, 2009 2034 Background: TRegs are increased in patients with GBM and constitutively express the high affinity interleukin-2 receptor (IL-2Rα). Treatment with an antibody that blocks IL-2Rα signaling functionally inactivates and eliminates TRegs without inducing a ... Link to item Cite

Epidermal growth factor receptor variant III (EGFRvIII) vaccine (CDX-110) in GBM.

Journal Article J Clin Oncol · May 20, 2009 2021 Background: Unlike conventional therapies for GBM, immunologic targeting of tumor-specific gene mutations allows precise eradication of neoplastic cells with reduced toxicity. EGFRvIII is a constitutively activated and immunogenic mutation not express ... Link to item Cite

Prognostic significance of early changes in the apparent diffusion coefficient that occurs after treatment of patients with glioblastoma multiforme with bevacizumab.

Journal Article J Clin Oncol · May 20, 2009 2058 Background: To determine the prognostic significance of changes in parameters derived from diffusion tensor imaging (DTI) that occur in response to combination chemotherapy with the antiangiogenesis agent bevacizumab (BEV) in patients with recurrent g ... Link to item Cite

Phase I trial of vendetanib and oral etoposide for recurrent malignant gliomas.

Journal Article J Clin Oncol · May 20, 2009 e13016 Background: Recurrent malignant gliomas have a poor prognosis, with a median survival of 6-15 months, with grade 4 glioblastomas more aggressive than grade 3 anaplastic astrocytomas or oligodendrogliomas. Vascular endothelial growth factor (VEGF) an ... Link to item Cite

Temozolomide (TMZ) and bevacizumab (BV) as initial treatment for unresectable or multifocal glioblastoma multiforme (GBM).

Journal Article J Clin Oncol · May 20, 2009 e13025 Background: GBMs are vascular tumors and inherently resistant to therapy. The prognosis for patients is poor with a median survival of 9-15 months. Patients with unresectable or multifocal GBMs have an even poorer prognosis, with a median survival o ... Link to item Cite

Neurocognitive function in patients with glioblastoma multiforme in first or second relapse treated with bevacizumab in the BRAIN study.

Journal Article J Clin Oncol · May 20, 2009 2056 Background: Patients with glioblastoma multiforme (GBM) suffer from neurocognitive decline due to both the disease and its treatment. We analyzed neurocognitive function of patients with recurrent GBM who participated in the BRAIN study, a phase II, m ... Link to item Cite

Phase II study of bevacizumab plus erlotinib for recurrent malignant gliomas.

Journal Article J Clin Oncol · May 20, 2009 2045 Background: Bevacizumab (B), a neutralizing VEGF monoclonal antibody, has anti-glioma activity as single agent and in combination with cytotoxic therapy. Erlotinib (E), an EGFR tyrosine kinase inhibitor, may exhibit anti-tumor activity in some maligna ... Link to item Cite

Safety and efficacy of the addition of bevacizumab (BV) to temozolomide (TMZ) and radiation therapy (RT) followed by BV, TMZ, and irinotecan (CPT-11) for newly diagnosed glioblastoma multiforme (GBM).

Journal Article J Clin Oncol · May 20, 2009 2015 Background: Standard GBM treatment includes TMZ and RT, and results in a median progression-free survival and median survival of 6.9 and 15.8 months, respectively. GBM have high concentrations of vascular endothelial growth factor (VEGF), higher level ... Link to item Cite

Phase I pharmacokinetic study of the vascular endothelial growth factor receptor tyrosine kinase inhibitor vatalanib (PTK787) plus imatinib and hydroxyurea for malignant glioma.

Journal Article Cancer · May 15, 2009 BACKGROUND: This study determined the maximum tolerated dose (MTD) and dose-limiting toxicities (DLT) of the oral vascular endothelial growth factor receptor (VEGFR) inhibitor, vatalanib, when administered with imatinib and hydroxyurea on a continuous dail ... Full text Link to item Cite

Repeatability of quantitative parameters derived from diffusion tensor imaging in patients with glioblastoma multiforme.

Journal Article J Magn Reson Imaging · May 2009 PURPOSE: To quantify the repeatability of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in patients with glioblastoma multiforme. MATERIALS AND METHODS: IRB approval and informed consent were obtained for this Health Insurance Portabi ... Full text Link to item Cite

Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma.

Journal Article J Clin Oncol · March 10, 2009 PURPOSE: This phase II trial was designed to define the role of O(6)-benzylguanine (O(6)-BG) in restoring temozolomide sensitivity in patients with recurrent or progressive, temozolomide-resistant malignant glioma and to evaluate the safety of administerin ... Full text Link to item Cite

BCNU-sequestration by metallothioneins may contribute to resistance in a medulloblastoma cell line.

Journal Article Cancer Chemother Pharmacol · March 2009 PURPOSE: Resistance of neoplastic cells to the alkylating drug BCNU [1,3-bis(2-chloroethyl)-1-nitrosourea] has been correlated with expression of O (6)-methylguanine-DNA methyltransferase, which repairs the O (6)-chloroethylguanine produced by the drug. Ot ... Full text Link to item Cite

IDH1 and IDH2 mutations in gliomas.

Journal Article N Engl J Med · February 19, 2009 BACKGROUND: A recent genomewide mutational analysis of glioblastomas (World Health Organization [WHO] grade IV glioma) revealed somatic mutations of the isocitrate dehydrogenase 1 gene (IDH1) in a fraction of such tumors, most frequently in tumors that wer ... Full text Link to item Cite

Phase II trial of Gliadel plus O6-benzylguanine in adults with recurrent glioblastoma multiforme.

Journal Article Clin Cancer Res · February 1, 2009 PURPOSE: This phase II trial was designed to define the efficacy of Gliadel wafers in combination with an infusion of O6-benzylguanine (O6-BG) that suppresses tumor O6-alkylguanine-DNA alkyltransferase (AGT) levels in patients with recurrent glioblastoma m ... Full text Link to item Cite

Experience with irinotecan for the treatment of malignant glioma.

Journal Article Neuro Oncol · February 2009 Malignant glioma is the most commonly occurring primary malignant brain tumor. It is difficult to treat and is usually associated with an inexorable, rapidly fatal clinical course. Chemotherapy, radiotherapy, and surgical excision are core components in th ... Full text Link to item Cite

Enterohepatic recirculation model of irinotecan (CPT-11) and metabolite pharmacokinetics in patients with glioma.

Journal Article Cancer Chemother Pharmacol · February 2009 BACKGROUND: Enterohepatic recirculation of irinotecan and one of its metabolites, SN-38, has been observed in pharmacokinetic data sets from previous studies. A mathematical model that can incorporate this phenomenon was developed to describe the pharmacok ... Full text Link to item Cite

Phase I study of SU5416, a small molecule inhibitor of the vascular endothelial growth factor receptor (VEGFR) in refractory pediatric central nervous system tumors.

Journal Article Pediatr Blood Cancer · February 2009 SU5416 is a novel small molecule tyrosine kinase inhibitor of the VEGF receptors 1 and 2. A phase I dose escalation study stratified by concurrent use (stratum II) or absence (stratum I) of enzyme-inducing anticonvulsant drugs was undertaken to estimate th ... Full text Link to item Cite

Genomic and molecular profiling predicts response to temozolomide in melanoma.

Journal Article Clin Cancer Res · January 15, 2009 PURPOSE: Despite objective response rates of only approximately 13%, temozolomide remains one of the most effective single chemotherapy agents against metastatic melanoma, second only to dacarbazine, the current standard of care for systemic treatment of m ... Full text Link to item Cite

Family appraisal of caregiving in a brain cancer model

Journal Article Journal of Hospice and Palliative Nursing · January 1, 2009 Caregivers of patients with brain tumors frequently provide care to a patient with a potentially short terminal disease trajectory. Understanding the impact of caregiving is important because caregivers are often called upon to make difficult decisions reg ... Full text Cite

Distress persists in long-term brain tumor survivors with glioblastoma multiforme.

Journal Article J Cancer Surviv · December 2008 INTRODUCTION: Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain tumor. The prognosis for GBM patients is extremely poor with an estimated median survival of 12 months. Despite this statistic, a number of GBM patients are ... Full text Link to item Cite

Detection of humoral response in patients with glioblastoma receiving EGFRvIII-KLH vaccines.

Journal Article J Immunol Methods · November 30, 2008 The epidermal growth factor receptor variant III (EGFRvIII) is a consistent tumor-specific mutation that is widely expressed in glioblastoma multiforme (GBM) and other neoplasms. As such it represents a truly tumor-specific target for antitumor immunothera ... Full text Link to item Cite

In reply

Journal Article Journal of Clinical Oncology · November 10, 2008 Full text Cite

Bevacizumab plus irinotecan in recurrent WHO grade 3 malignant gliomas.

Journal Article Clin Cancer Res · November 1, 2008 PURPOSE: Although patients with newly diagnosed WHO grade 3 malignant glioma have a more favorable prognosis than those with WHO grade 4 malignant glioma, salvage therapies following recurrence offer essentially palliative benefit. We did a phase II trial ... Full text Link to item Cite

Dose intensive melphalan and cyclophosphamide with autologous hematopoietic stem cells for recurrent medulloblastoma or germinoma.

Journal Article Pediatr Blood Cancer · November 2008 PURPOSE: To determine the response, toxicity, and survival for children with progressive or recurrent medulloblastoma and germinoma using a single myeloablative course of chemotherapy supported by autologous hematopoietic stem cells. PATIENTS AND METHODS: ... Full text Link to item Cite

Efficacy of high-dose chemotherapy or standard salvage therapy in patients with recurrent medulloblastoma.

Journal Article Neuro Oncol · October 2008 The efficacy of high-dose chemotherapy (HDC) or standard salvage therapy was evaluated in patients with recurrent medulloblastoma (MBL) using retrospective chart review of all patients with recurrent MBL treated at Duke University Medical Center between 19 ... Full text Link to item Cite

Bevacizumab drove 6-month survival in glioblastoma: Commentary

Journal Article Oncology Report · September 1, 2008 Cite

Mismatch repair deficiency does not mediate clinical resistance to temozolomide in malignant glioma.

Journal Article Clin Cancer Res · August 1, 2008 PURPOSE: A major mechanism of resistance to methylating agents, including temozolomide, is the DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (AGT). Preclinical data indicates that defective DNA mismatch repair (MMR) results in tolerance to temo ... Full text Link to item Cite

In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs.

Journal Article Br J Cancer · July 22, 2008 TRAIL/Apo-2L has shown promise as an anti-glioma drug, based on investigations of TRAIL sensitivity in established glioma cell lines, but it is not known how accurately TRAIL signalling pathways of glioma cells in vivo are reproduced in these cell lines in ... Full text Link to item Cite

Molecular characterization of the pediatric preclinical testing panel.

Journal Article Clin Cancer Res · July 15, 2008 PURPOSE: Identifying novel therapeutic agents for the treatment of childhood cancers requires preclinical models that recapitulate the molecular characteristics of their respective clinical histotypes. EXPERIMENTAL DESIGN AND RESULTS: Here, we have applied ... Full text Link to item Cite

Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors.

Journal Article Neuro Oncol · June 2008 The purpose of this study is to determine the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), and intracerebral distribution of a recombinant toxin (TP-38) targeting the epidermal growth factor receptor in patients with recurrent malignant brai ... Full text Link to item Cite

Safety and pharmacokinetics of dose-intensive imatinib mesylate plus temozolomide: phase 1 trial in adults with malignant glioma.

Journal Article Neuro Oncol · June 2008 We determined the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of imatinib mesylate, an inhibitor of the receptor tyrosine kinases platelet-derived growth factor receptor (PDGFR), the proto-oncogene product c-kit, and the fusion protein Bc ... Full text Link to item Cite

Screening for distress in patients with brain cancer using the NCCN's rapid screening measure.

Journal Article Psychooncology · June 2008 GOALS OF WORK: Patients with brain cancer are at a risk of experiencing elevated levels of distress due to the severe functional, neurocognitive, and neuropsychological sequelae of the disease. Using the National Comprehensive Cancer Network's Distress The ... Full text Link to item Cite

Final report: Phase I trial of imatinib mesylate, hydroxyurea, and vatalanib for patients with recurrent malignant glioma (MG).

Journal Article J Clin Oncol · May 20, 2008 2057 Background: Angiogenesis is a hallmark of MG with VEGF as a key regulator. Imatinib mesylate (IM) and hydroxyurea (H) have recently demonstrated promising anti-glioma activity. We attempt to extend the efficacy of IM and H by adding a VEGF receptor in ... Link to item Cite

Bevacizumab and daily temozolomide for recurrent glioblastoma multiforme (GBM)

Journal Article Journal of Clinical Oncology · May 20, 2008 Full text Cite

The gene expression profiles of medulloblastoma cell lines resistant to preactivated cyclophosphamide.

Journal Article Curr Cancer Drug Targets · May 2008 The total expression profiles of two medulloblastoma cell lines resistant to the preactivated form of cyclophosphamide (4-hydroperoxycyclophosphamide, 4-HC) were examined using the Affymetrix GeneChip U133A array. Our primary objective was to look for poss ... Full text Link to item Cite

Immunotherapy against angiogenesis-associated targets: evidence and implications for the treatment of malignant glioma.

Journal Article Expert Rev Anticancer Ther · May 2008 Angiogenesis, the growth of new blood vessels from previously existing vasculature, is a requirement for tumor growth and metastasis. The first US FDA-approved drugs targeting angiogenesis have shown potential in the treatment of malignant gliomas. Immunot ... Full text Link to item Cite

A pilot study: 131I-antitenascin monoclonal antibody 81c6 to deliver a 44-Gy resection cavity boost.

Journal Article Neuro Oncol · April 2008 The purpose of this study was to determine the feasibility and assess the efficacy and toxicity, among newly diagnosed malignant glioma patients, of administering (131)I-labeled murine antitenascin monoclonal antibody 81C6 ((131)I-81C6) into a surgically c ... Full text Link to item Cite

In reply

Journal Article Journal of Clinical Oncology · February 20, 2008 Full text Cite

Phase I trial of VNP40101M (Cloretazine) in children with recurrent brain tumors: a pediatric brain tumor consortium study.

Journal Article Clin Cancer Res · February 15, 2008 PURPOSE: VNP40101M (Cloretazine), a novel DNA alkylating agent, was evaluated in a phase I study in children with recurrent brain tumors. EXPERIMENTAL DESIGN: VNP40101M was given i.v. daily for 5 consecutive days every 6 weeks for up to eight cycles. Dose ... Full text Link to item Cite

Multifocal anaplastic astrocytoma in a patient with hereditary colorectal cancer, transcobalamin II deficiency, agenesis of the corpus callosum, mental retardation, and inherited PMS2 mutation.

Journal Article Neuro Oncol · February 2008 We describe the case of a patient with transcobalamin II deficiency, hypogammaglobulinemia, absent corpus callosum, and mental retardation who presented at an early age with colorectal cancer and multifocal anaplastic astrocytoma. He was found to have a po ... Full text Link to item Cite

Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan.

Journal Article J Clin Oncol · January 10, 2008 PURPOSE: The combination of a vascular endothelial growth factor (VEGF) -neutralizing antibody, bevacizumab, and irinotecan is associated with high radiographic response rates and improved survival outcomes in patients with recurrent malignant gliomas. The ... Full text Link to item Cite

Clinical experience with alpha-particle emitting 211At: treatment of recurrent brain tumor patients with 211At-labeled chimeric antitenascin monoclonal antibody 81C6.

Journal Article J Nucl Med · January 2008 UNLABELLED: alpha-Particle-emitting radionuclides, such as (211)At, with a 7.2-h half-life, may be optimally suited for the molecularly targeted radiotherapy of strategically sensitive tumor sites, such as those in the central nervous system. Because of th ... Full text Link to item Cite

Stress and long-term survivors of brain cancer.

Journal Article Support Care Cancer · December 2007 INTRODUCTION: Adult brain tumor patients are joining the ranks of cancer survivors in increasing numbers in the United States. As a result, health care providers are faced with new challenges to address the need for psychosocial support in this population. ... Full text Link to item Cite

The pediatric preclinical testing program: description of models and early testing results.

Journal Article Pediatr Blood Cancer · December 2007 BACKGROUND: The Pediatric Preclinical Testing Program (PPTP) is an initiative supported by the National Cancer Institute (NCI) to identify novel therapeutic agents that may have significant activity against childhood cancers. The PPTP has established panel ... Full text Link to item Cite

Phase I trial of single-dose temozolomide and continuous administration of o6-benzylguanine in children with brain tumors: a pediatric brain tumor consortium report.

Journal Article Clin Cancer Res · November 15, 2007 PURPOSE: To estimate the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of escalating doses of temozolomide combined with O(6)-benzylguanine in patients < or =21 years with recurrent brain tumors. EXPERIMENTAL DESIGN: Treatment strata consis ... Full text Link to item Cite

O (4)-benzylfolic acid inactivates O (6)-alkylguanine-DNA alkyltransferase in brain tumor cell lines.

Journal Article Cancer Chemother Pharmacol · November 2007 PURPOSE: The DNA repair protein, O (6)-alkylguanine-DNA alkyltransferase (AGT), is a primary source of tumor resistance to agents such as temozolomide and chloroethylnitrosoureas that form DNA lesions at the O (6)-position of guanines. To increase the effi ... Full text Link to item Cite

Bevacizumab plus irinotecan in recurrent glioblastoma multiforme.

Journal Article J Clin Oncol · October 20, 2007 PURPOSE: The prognosis for patients with recurrent glioblastoma multiforme is poor, with a median survival of 3 to 6 months. We performed a phase II trial of bevacizumab, a monoclonal antibody to vascular endothelial growth factor, in combination with irin ... Full text Link to item Cite

Interstitial chemotherapy with biodegradable BCNU (Gliadel) wafers in the treatment of malignant gliomas.

Journal Article Ther Clin Risk Manag · October 2007 Malignant gliomas represent the majority of primary brain tumors, and the prognosis of the patients afflicted with these tumors has been historically dismal, with almost uniform progressive neurologic impairment and rapid death. Even with multimodal treatm ... Link to item Cite

Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.

Journal Article Cancer · October 1, 2007 BACKGROUND: Effective chemotherapy is lacking for most types of central nervous system (CNS) tumors in children. Temozolomide, an agent with activity against adult brain tumors, was investigated in children and adolescents with recurrent CNS tumors. METHOD ... Full text Link to item Cite

The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of rapamycin (RAD001) decreases glioma proliferation and invasion.

Journal Article Mol Cancer Ther · September 2007 Monotherapies have proven largely ineffective for the treatment of glioblastomas, suggesting that increased patient benefit may be achieved by combining therapies. Two protumorigenic pathways known to be active in glioblastoma include RAS/RAF/mitogen-activ ... Full text Link to item Cite

Dendritic cell vaccine shows promise in glioblastoma: Commentary

Journal Article Oncology Report · September 1, 2007 Cite

Motexafin gadolinium delays progression in NSCLC brain metastases: Commentary

Journal Article Oncology Report · September 1, 2007 Cite

Bevacizumab plus irinotecan stalls recurrent gliomas: Commentary

Journal Article Oncology Report · September 1, 2007 Cite

VEGF inhibitor cediranib active in recurrent glioblastoma: Commentary

Journal Article Oncology Report · September 1, 2007 Cite

Temozolomide and vaccination can work together to treat GBM: Commentary

Journal Article Oncology Report · September 1, 2007 Cite

The fallacy of single-agent chemotherapy for cancer.

Journal Article J Clin Oncol · August 10, 2007 Full text Link to item Cite

Activity of VNP40101M (Cloretazine) in the treatment of CNS tumor xenografts in athymic mice.

Journal Article Neuro Oncol · July 2007 VNP40101M, or 1,2-bis(methylsulfonyl)-1-(2-choloroethyl)-2-(methylamino)carbonylhydrazine (Cloretazine), is a bifunctional prodrug that belongs to a class of DNA-modifying agents-the sulfonylhydrazines-that has been synthesized and been shown to have activ ... Full text Link to item Cite

Tinzaparin prophylaxis in brain tumor patients

Conference JOURNAL OF CLINICAL ONCOLOGY · June 20, 2007 Link to item Cite

A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth.

Journal Article Mol Carcinog · June 2007 Glioblastomas are highly lethal cancers that resist current therapies. Novel therapies under development target molecular mechanisms that promote glioblastoma growth. In glioblastoma patient specimens, the non-receptor tyrosine kinase focal adhesion kinase ... Full text Link to item Cite

Tumor resection cavity administered iodine-131-labeled antitenascin 81C6 radioimmunotherapy in patients with malignant glioma: neuropathology aspects.

Journal Article Nucl Med Biol · May 2007 INTRODUCTION: The neurohistological findings in patients treated with targeted beta emitters such as (131)I are poorly described. We report a histopathologic analysis from patients treated with combined external beam therapy and a brachytherapy consisting ... Full text Link to item Cite

Defining regional infusion treatment strategies for extremity melanoma: comparative analysis of melphalan and temozolomide as regional chemotherapeutic agents.

Journal Article Mol Cancer Ther · May 2007 Five different human melanoma xenografts were used in a xenograft model of extremity melanoma to evaluate the variability of tumor response to regionally administered melphalan or temozolomide and to determine if various components of pertinent drug resist ... Full text Link to item Cite

Phase II study of imatinib mesylate and hydroxyurea for recurrent grade III malignant gliomas.

Journal Article J Neurooncol · May 2007 PURPOSE: Recent reports demonstrate the activity of imatinib mesylate, an ATP-mimetic, tyrosine kinase inhibitor, plus hydroxyurea, a ribonucleotide reductase inhibitor, in patients with recurrent glioblastoma multiforme. We performed the current phase 2 s ... Full text Link to item Cite

Temozolomide in children with progressive low-grade glioma.

Journal Article Neuro Oncol · April 2007 We conducted a phase II study to assess the efficacy of oral temozolomide (TMZ) in children with progressive low-grade glioma. Thirty eligible patients were enrolled on this study. Median age at enrollment was 10 years (range, 4-18 years). Eligible patient ... Full text Link to item Cite

Phase I trial of imatinib in children with newly diagnosed brainstem and recurrent malignant gliomas: a Pediatric Brain Tumor Consortium report.

Journal Article Neuro Oncol · April 2007 This study estimated the maximum tolerated dose (MTD) of imatinib with irradiation in children with newly diagnosed brainstem gliomas, and those with recurrent malignant intracranial gliomas, stratified according to use of enzyme-inducing anticonvulsant dr ... Full text Link to item Cite

Using the theory of planned behavior to understand the determinants of exercise intention in patients diagnosed with primary brain cancer.

Journal Article Psychooncology · March 2007 The purpose of the present study was to examine the demographic, medical, and social cognitive determinants of exercise intentions in a institution-based cohort of primary brain tumor patients. Using a cross-sectional survey, 100 primary brain tumor patien ... Full text Link to item Cite

Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma.

Journal Article Clin Cancer Res · February 15, 2007 PURPOSE: Recurrent grade III-IV gliomas have a dismal prognosis with minimal improvements in survival seen following currently available salvage therapy. This study was conducted to determine if the combination of a novel antiangiogenic therapy, bevacizuma ... Full text Link to item Cite

Intracerebral infusate distribution by convection-enhanced delivery in humans with malignant gliomas: descriptive effects of target anatomy and catheter positioning.

Journal Article Neurosurgery · February 2007 OBJECTIVE: Convection-enhanced delivery (CED) holds tremendous potential for drug delivery to the brain. However, little is known about the volume of distribution achieved within human brain tissue or how target anatomy and catheter positioning influence d ... Full text Link to item Cite

Phase II study of Cloretazine for the treatment of adults with recurrent glioblastoma multiforme.

Journal Article Neuro Oncol · January 2007 Cloretazine (VNP40101M) is a newly synthesized alkylating agent belonging to a novel class of alkylating agents called 1,2-bis(sulfonyl)hydrazines. Agents that belong to this class do not produce vinylating and chloroethylating species, and hence this clas ... Full text Link to item Cite

Exercise interest and preferences among patients diagnosed with primary brain cancer.

Journal Article Support Care Cancer · January 2007 GOALS OF THE WORK: The purpose of the present investigation was to examine the interest and exercise preferences of an institution-based sample of brain tumor patients. Secondary aims were to examine potential differences in participant's interest and pref ... Full text Link to item Cite

Stress and intervention preferences of patients with brain tumors.

Journal Article Support Care Cancer · December 2006 BACKGROUND: Despite advances in diagnosis, treatment, and management of brain tumors, a brain tumor (BT) can significantly disrupt a person's life and create stress. To design effective stress reduction interventions, it is essential to have an understandi ... Full text Link to item Cite

Differential levels of stress in caregivers of brain tumor patients--observations from a pilot study.

Journal Article Support Care Cancer · December 2006 OBJECTIVE: Caregivers of patients with brain tumors (BT) experience elevated levels of stress. Using pilot data, we sought to determine which caregivers are at risk for experiencing elevated levels of stress based on caregiver-demographic and patient-medic ... Full text Link to item Cite

Treatment of neoplastic meningitis with intrathecal 9-nitro-camptothecin.

Journal Article Neurol Med Chir (Tokyo) · October 2006 The topoisomerase I inhibitor, 9-nitro-camptothecin (9NC), is highly tumoricidal against glioblastoma multiforme (GBM) in vitro. However, systemic administration of 9NC has not shown the expected efficacy in clinical trials. This failure may be due to the ... Full text Link to item Cite

Quantitative analysis of O6-alkylguanine-DNA alkyltransferase in malignant glioma.

Journal Article Mol Cancer Ther · October 2006 Promoter hypermethylation of the DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (AGT) has been associated with an enhanced response to chloroethylating and methylating agents in patients with malignant glioma. The purpose of this study was to co ... Full text Link to item Cite

AAL881, a novel small molecule inhibitor of RAF and vascular endothelial growth factor receptor activities, blocks the growth of malignant glioma.

Journal Article Cancer Res · September 1, 2006 Malignant gliomas are highly proliferative and angiogenic cancers resistant to conventional therapies. Although RAS and RAF mutations are uncommon in gliomas, RAS activity is increased in gliomas. Additionally, vascular endothelial growth factor and its co ... Full text Link to item Cite

Spontaneous necrosis influences the accuracy of glioma grading: Comment

Journal Article Oncology Report · September 1, 2006 Cite

Age, resection status fail to define risk in glioma: Comment

Journal Article Oncology Report · September 1, 2006 Cite

Modafinil improves neurocognitive function in brain tumor patients: Comment

Journal Article Oncology Report · September 1, 2006 Cite

A novel low molecular weight inhibitor of focal adhesion kinase and insulin-like growth factor-1 receptor, TAE226, inhibits glioma growth.

Journal Article J Clin Oncol · June 20, 2006 11505 Background: Glioblastomas are highly lethal cancers that resist current therapies. Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase overexpressed in glioblastoma patient specimens that may promote glioma growth and invasion by increasing ... Link to item Cite

Combination of bevacizumab, a monoclonal antibody to vascular endothelial growth factor (VEGF), and temozolomide: Study of cases.

Journal Article J Clin Oncol · June 20, 2006 11522 Background: The prognosis for glioblastoma multiforme remains poor. Survival is generally limited to less than 1 year. Currently available standard treatments have not allowed, thus far, to prolong survival significantly. Response rates observed in c ... Link to item Cite

Acute toxicity analysis of patients receiving surgery, Gliadel wafer implantation, and postoperative daily temozolomide with radiation therapy for primary high-grade glioma.

Journal Article J Clin Oncol · June 20, 2006 11504 Background: Treatment of patients with newly diagnosed malignant glioma using Gliadel wafer implantation at initial surgery has been shown to increase survival (Westphal et al 2003). Similarly, administration of temozolomide during and after radiothe ... Link to item Cite

A phase I trial of imatinib, hydroxyurea and RAD001 for patients with recurrent malignant glioma.

Journal Article J Clin Oncol · June 20, 2006 1580 Background: This study attempts to extend the anti-glioma activity of imatinib mesylate (Gleevec, IM) plus hydroxyurea (H), by adding RAD001 (R), an orally bioavailable inhibitor of mTOR, a critical intracellular mediator of signal transduction and me ... Link to item Cite

Phase II trial of imatinib mesylate and hydroxyurea for grade III malignant gliomas.

Journal Article J Clin Oncol · June 20, 2006 1573 Background: We evaluated the combination of imatinib mesylate (Gleevec) and hydroxyurea in WHO grade III malignant gliomas following the encouraging response of this combination demonstrated in glioblastoma multiforme. METHODS: Eligibility: adult pati ... Link to item Cite

A phase II study of temozolomide and oral VP-16 for adults with recurrent glioma-Final results.

Journal Article J Clin Oncol · June 20, 2006 1565 Background: Although temozolomide has proven activity in patients with high and low grade gliomas, many patients do not respond, and for those who do, responses are often short-lived. We therefore undertook a trial of temozolomide in combination with ... Link to item Cite

An update on phase I study of dose-escalating imatinib mesylate plus standard-dosed temozolomide for the treatment of patients with malignant glioma.

Journal Article J Clin Oncol · June 20, 2006 1560 Background: Imatinib mesylate, a kinase inhibitor of the PDGF receptor has been shown to decrease tumor interstitial pressure resulting in enhanced delivery of cytotoxic therapy. Recent phase II trial demonstrated promising anti-glioma activity of ima ... Link to item Cite

Phase II trial of Gliadel plus O(6)-benzylguanine (O(6)-BG) for patients with recurrent glioblastoma multiforme.

Journal Article J Clin Oncol · June 20, 2006 1568 Background. The major mechanism of resistance to alkylnitrosourea therapy involves the DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (AGT) which removes chloroethylation or methylation damage from the O(6)-position of guanine. O(6)-BG is a ... Link to item Cite

Bevacizumab, a monoclonal antibody to vascular endothelial growth factor (VEGF), and irinotecan for treatment of malignant gliomas.

Journal Article J Clin Oncol · June 20, 2006 1506 Background: The prognosis for recurrent malignant gliomas is poor, with a median survival <12 months, median progression-free survival <12 weeks and response rates <20%. Malignant gliomas have high concentrations of VEGF receptors, and the higher the ... Link to item Cite

Tinzaparin prophylaxis against thromboembolic complications in brain tumor patients.

Journal Article J Clin Oncol · June 20, 2006 1539 Background: Thromboembolic complications are common in brain tumor patients, contribute to the morbidity and mortality and complicate treatment. Twenty to 40% of brain tumor patients develop a deep venous thrombosis and/or pulmonary embolus during the ... Link to item Cite

Novel human IgG2b/murine chimeric antitenascin monoclonal antibody construct radiolabeled with 131I and administered into the surgically created resection cavity of patients with malignant glioma: phase I trial results.

Journal Article J Nucl Med · June 2006 UNLABELLED: Results from animal experiments have shown that human IgG2/mouse chimeric antitenascin 81C6 (ch81C6) monoclonal antibody exhibited higher tumor accumulation and enhanced stability compared with its murine parent. Our objective was to determine ... Link to item Cite

Patterns of exercise across the cancer trajectory in brain tumor patients.

Journal Article Cancer · May 15, 2006 BACKGROUND: Exercise may represent a supportive intervention that may complement existing neurooncologic therapies and address a multitude of therapy-induced debilitating side effects in patients with brain tumors. Given the limited evidence, the authors c ... Full text Link to item Cite

Radiotherapy in pediatric medulloblastoma: quality assessment of Pediatric Oncology Group Trial 9031.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2006 PURPOSE: To evaluate the potential influence of radiotherapy quality on survival in high-risk pediatric medulloblastoma patients. METHODS AND MATERIALS: Trial 9031 of the Pediatric Oncology Group (POG) aimed to study the relative benefit of cisplatin and e ... Full text Link to item Cite

A phase II window trial of procarbazine and topotecan in children with high-grade glioma: a report from the children's oncology group.

Journal Article J Neurooncol · April 2006 The role of chemotherapy in the treatment of high-grade gliomas in children is unclear. Early reports were suggestive of improved outcome in children with high-grade glioma with the addition of chemotherapy after surgery and radiation therapy. Subsequent s ... Full text Link to item Cite

Incidence and patterns of neuraxis metastases in children with diffuse pontine glioma.

Journal Article J Neurooncol · April 2006 PURPOSE: We performed a retrospective study of patients with diffuse pontine glioma (DPG) who suffered neuraxis metastasis (NM) and characterized the incidence, clinical features, radiologic findings, and patterns of disease dissemination. METHODS: Magneti ... Full text Link to item Cite

Molecular imaging of alkylguanine-DNA alkyltransferase: further evaluation of radioiodinated derivatives of O6-benzylguanine.

Journal Article Nucl Med Biol · April 2006 PURPOSE: An inverse correlation has been established between tumor levels of the DNA repair protein alkylguanine-DNA alkyltransferase (AGT) and a positive outcome after alkylator chemotherapy. Quantitative imaging of AGT could provide important information ... Full text Link to item Cite

Recent advances in the treatment of malignant astrocytoma.

Journal Article J Clin Oncol · March 10, 2006 Malignant gliomas, including the most common subtype, glioblastoma multiforme (GBM), are among the most devastating of neoplasms. Their aggressive infiltration in the CNS typically produces progressive and profound disability--ultimately leading to death i ... Full text Link to item Cite

Modulation of chemotherapy resistance in regional therapy: a novel therapeutic approach to advanced extremity melanoma using intra-arterial temozolomide in combination with systemic O6-benzylguanine.

Journal Article Mol Cancer Ther · March 2006 This study investigated whether the therapeutic index of regional melanoma therapy using parenteral temozolomide could be improved by chemomodulation with O6-benzylguanine (O6BG), an inhibitor of the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase ( ... Full text Link to item Cite

Phase I trial of intrathecal spartaject busulfan in children with neoplastic meningitis: a Pediatric Brain Tumor Consortium Study (PBTC-004).

Journal Article Clin Cancer Res · March 1, 2006 PURPOSE: A phase I trial of intrathecal Spartaject Busulfan (SuperGen, Inc., San Ramon, CA) was conducted in children with neoplastic meningitis following recurrent primary brain tumors to describe toxicities, estimate the maximum tolerated dose (MTD), and ... Full text Link to item Cite

Moxifloxacin versus levofloxacin for treatment of acute rhinosinusitis: a retrospective database analysis of treatment duration, outcomes, and charges.

Journal Article Current medical research and opinion · February 2006 OBJECTIVE: Antibiotics are clinically indicated for acute bacterial rhinosinusitis, but they may be prescribed inappropriately. This retrospective study examined how labeled recommendations for duration of moxifloxacin and levofloxacin treatment of acute b ... Cite

Phase 1 trial of gefitinib plus sirolimus in adults with recurrent malignant glioma.

Journal Article Clin Cancer Res · February 1, 2006 PURPOSE: To determine the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of gefitinib, a receptor tyrosine kinase inhibitor of the epidermal growth factor receptor, plus sirolimus, an inhibitor of the mammalian target of rapamycin, among pat ... Full text Link to item Cite

The role of chemoresistance in regional infusion therapy for melanoma

Conference ANNALS OF SURGICAL ONCOLOGY · February 1, 2006 Link to item Cite

Brain tumor patients: Stress and intervention preferences

Journal Article PSYCHO-ONCOLOGY · February 1, 2006 Link to item Cite

Optimizing a novel regional chemotherapeutic agent against melanoma: hyperthermia-induced enhancement of temozolomide cytotoxicity.

Journal Article Clin Cancer Res · January 1, 2006 PURPOSE: Previous preclinical studies have shown that regional temozolomide therapy via isolated limb infusion is more effective than melphalan, the current drug of choice for regional chemotherapy for advanced extremity melanoma. The aim of this study was ... Full text Link to item Cite

Salvage radioimmunotherapy with murine iodine-131-labeled antitenascin monoclonal antibody 81C6 for patients with recurrent primary and metastatic malignant brain tumors: phase II study results.

Journal Article J Clin Oncol · January 1, 2006 PURPOSE: To assess the efficacy and toxicity of intraresection cavity iodine-131-labeled murine antitenascin monoclonal antibody 81C6 (131I-m81C6) among recurrent malignant brain tumor patients. PATIENTS AND METHODS: In this phase II trial, 100 mCi of 131I ... Full text Link to item Cite

Synthesis and evaluation of glycosylated octreotate analogues labeled with radioiodine and 211At via a tin precursor.

Journal Article Bioconjug Chem · 2006 Carbohydration of N-terminus and substitution of a threonine for the threoninol residue at the C-terminus of Tyr3-octreotide (TOC) has resulted in improved pharmacokinetics and tumor targeting of its radioiodinated derivatives. Yet, these peptides are very ... Full text Link to item Cite

Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme.

Journal Article J Clin Oncol · December 20, 2005 PURPOSE: We performed a phase II study to evaluate the combination of imatinib mesylate, an adenosine triphosphate mimetic, tyrosine kinase inhibitor, plus hydroxyurea, a ribonucleotide reductase inhibitor, in patients with recurrent glioblastoma multiform ... Full text Link to item Cite

Ependymoma

Journal Article · December 1, 2005 Full text Cite

ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors.

Journal Article Clin Cancer Res · November 15, 2005 PURPOSE: Primary central nervous system (CNS) tumors represent a diverse group of tumor types with heterogeneous molecular mechanisms that underlie their formation and maintenance. CNS tumors depend on angiogenesis and often display increased activity of E ... Full text Link to item Cite

Longevity following the experience of parental divorce.

Journal Article Social science & medicine · November 2005 An archival prospective design was used to study mediating and moderating variables for the association between parental divorce and increased mortality risk, using a sub-group (n = 1183) of individuals from the US Terman Life Cycle Study covering the peri ... Cite

Survival analysis of presumptive prognostic markers among oligodendrogliomas.

Journal Article Cancer · October 15, 2005 BACKGROUND: Allelic losses of 1p and 19q arms correlate with the oligodendroglial phenotype as well as with sensitivity to radiotherapy and chemotherapy. Furthermore, the DNA repair gene, methylguanine methyltransferase (MGMT), is diminished in 80% of olig ... Full text Link to item Cite

Etoposide, vincristine, and cyclosporin A with standard-dose radiation therapy in newly diagnosed diffuse intrinsic brainstem gliomas: a pediatric oncology group phase I study.

Journal Article Pediatr Blood Cancer · October 15, 2005 BACKGROUND: Brainstem gliomas (BSGs) are resistant to all therapy. Based on their imaging characteristics, we postulated that inhibition of P-glycoprotein (P-gp) associated with endothelial cells of the blood-brain barrier might enhance penetration of xeno ... Full text Link to item Cite

Phase I trial of irinotecan plus temozolomide in adults with recurrent malignant glioma.

Journal Article Cancer · October 1, 2005 BACKGROUND: The authors determined the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of irinotecan (CPT-11), a topoisomerase I inhibitor, when administered with temozolomide among patients with recurrent malignant glioma (MG). METHODS: Pati ... Full text Link to item Cite

Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.

Journal Article J Clin Oncol · October 1, 2005 PURPOSE: We conducted a two-phase clinical trial in patients with progressive malignant glioma (MG). The first phase of this trial was designed to determine the dose of O6-BG effective in producing complete depletion of tumor AGT activity for 48 hours. The ... Full text Link to item Cite

Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft.

Journal Article Mol Cancer Ther · September 2005 Temozolomide is a DNA-methylating agent used in the treatment of malignant gliomas. In this study, we have examined if inhibition of poly(ADP-ribose) polymerase (PARP) could increase the cytotoxicity of temozolomide, particularly in cells deficient in DNA ... Full text Link to item Cite

Chemotherapy and novel therapeutic approaches in malignant glioma.

Journal Article Front Biosci · September 1, 2005 Glial neoplasms represent 0.5-1% of all cancers in most Western countries. Malignant gliomas are among the most devastating cancers, leading to death in most cases. They present unique challenges due to their location, aggressive biological behavior and di ... Full text Link to item Cite

Can PFS predict overall survival. Comment

Journal Article Oncology Report · September 1, 2005 Cite

Peritumoral administration best way to deliver ILI3PE. Comment

Journal Article Oncology Report · September 1, 2005 Cite

Thalidomide does not improve survival. Comment

Journal Article Oncology Report · September 1, 2005 Cite

Dosimetry and radiographic analysis of 131I-labeled anti-tenascin 81C6 murine monoclonal antibody in newly diagnosed patients with malignant gliomas: a phase II study.

Journal Article J Nucl Med · June 2005 UNLABELLED: The objective was to perform dosimetry and evaluate dose-response relationships in newly diagnosed patients with malignant brain tumors treated with direct injections of (131)I-labeled anti-tenascin murine 81C6 monoclonal antibody (mAb) into su ... Link to item Cite

Promising results in overcoming temozolomide resistance

Journal Article Oncology Report · March 1, 2005 Cite

Carotid-artery stenting versus endarterectomy.

Journal Article The New England journal of medicine · February 2005 Cite

Phase I clinical trial of mafosfamide in infants and children aged 3 years or younger with newly diagnosed embryonal tumors: a pediatric brain tumor consortium study (PBTC-001).

Journal Article J Clin Oncol · January 20, 2005 PURPOSE: A phase I trial of intrathecal (IT) mafosfamide was performed to determine the optimal dose, dose-limiting toxicities, and incidence and severity of other toxicities when administered in association with concomitant multiagent systemic chemotherap ... Full text Link to item Cite

Phase II trial of irinotecan plus celecoxib in adults with recurrent malignant glioma.

Journal Article Cancer · January 15, 2005 BACKGROUND: In the current study, the authors report a Phase II trial of irinotecan (CPT-11), a topoisomerase I inhibitor active against malignant glioma (MG), with celecoxib, a selective COX-2 inhibitor, among MG patients with recurrent disease. METHODS: ... Full text Link to item Cite

Comparison of ante- and post-mortem PSA levels for epidemiological studies.

Journal Article Anticancer Res · 2005 BACKGROUND: Valuable correlations could be made between serum prostate specific antigen (PSA) and prostate histopathology by the use of autopsy sampling if post-mortem PSA data were informative. However, PSA forms and levels in autopsy sera have not been i ... Link to item Cite

Sustained radiographic and clinical response in patient with bifrontal recurrent glioblastoma multiforme with intracerebral infusion of the recombinant targeted toxin TP-38: case study.

Journal Article Neuro Oncol · January 2005 Glioblastoma multiforme remains refractory to conventional therapy, and novel therapeutic modalities are desperately needed. TP-38 is a recombinant chimeric protein containing a genetically engineered form of the cytotoxic Pseudomonas exotoxin fused to tra ... Full text Link to item Cite

Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition.

Journal Article Mol Cancer Ther · January 2005 Malignant gliomas are highly lethal tumors that display striking genetic heterogeneity. Novel therapies that inhibit a single molecular target may slow tumor progression, but tumors are likely not dependent on a signal transduction pathway. Rather, maligna ... Link to item Cite

Secreted protein acidic, rich in cysteine (SPARC), mediates cellular survival of gliomas through AKT activation.

Journal Article J Biol Chem · December 10, 2004 Secreted protein acidic, rich in cysteine (SPARC), is an extracellular matrix protein expressed in many advanced cancers, including malignant gliomas. We and others have previously shown that human glioma cell lines engineered to overexpress SPARC adopt an ... Full text Link to item Cite

Temozolomide is a novel regional infusion agent for the treatment of advanced extremity melanoma.

Journal Article Am J Surg · November 2004 BACKGROUND: Regional infusion therapy with melphalan (LPAM) is an accepted treatment for advanced extremity melanoma. However, much room exists for improving the therapeutic index of this type of therapy. METHODS: Isolated limb infusion (ILI) with temozolo ... Full text Link to item Cite

Recent advances in the treatment of pediatric brain tumors.

Journal Article Oncology (Williston Park) · November 2004 Central nervous system (CNS) cancers are the second most frequent malignancy (and the most common solid tumor) in childhood. In recent years, significant advances in surgery, radiotherapy, and chemotherapy have improved survival in children with these tumo ... Link to item Cite

A 4-methyl-substituted meta-iodobenzylguanidine analogue with prolonged retention in human neuroblastoma cells.

Journal Article Eur J Nucl Med Mol Imaging · October 2004 PURPOSE: As a part of our efforts to develop a meta-iodobenzylguanidine (MIBG) analogue with improved characteristics for the diagnosis and treatment of neuroendocrine tumours, 3-[131I]iodo-4-methyl-benzylguanidine ([131I]MeIBG) has been developed. The pur ... Full text Link to item Cite

Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations.

Journal Article Mol Cancer Ther · September 2004 The chemotherapeutic activity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU or carmustine) may be improved by the addition of O6-benzylguanine (O6-BG). The reaction of O6-BG with O6-alkylguanine-DNA alkyltransferase (AGT) prevents the repair of O6-chloroet ... Link to item Cite

In-transit melanoma: the role of alkylating-agent resistance in regional therapy.

Journal Article J Am Coll Surg · September 2004 BACKGROUND: Regional perfusion treatments for melanoma, using the alkylating agent melphalan, show variable responses in magnitude and duration. Surprisingly, the potential contribution of alkylating-agent resistance mechanisms to diminish tumor responses, ... Full text Link to item Cite

Comparative genomic hybridization analysis of astrocytomas: prognostic and diagnostic implications.

Journal Article J Mol Diagn · August 2004 Astrocytoma is comprised of a group of common intracranial neoplasms that are classified into four grades based on the World Health Organization histological criteria and patient survival. To date, histological grade, patient age, and clinical performance, ... Full text Link to item Cite

Modulation of resistance to regional chemotherapy in the extremity melanoma model.

Journal Article Surgery · August 2004 BACKGROUND: The presence of resistance to chemotherapy is associated with poor tumor response and patient survival in a variety of tumors. Attempts to modulate resistance in conjunction with systemic chemotherapy have been limited by the toxicity of combin ... Full text Link to item Cite

Phase II trial of iodine 131-labeled murine anti-tenascin monoclonal anti-body 81C6 (M81C6) via surgically created resection cavity in the treatment of patients with recurrent malignant brain tumors.

Journal Article J Clin Oncol · July 15, 2004 1569 Background: In a prior phase I study we established the dose of 100mCi as the maximum tolerated dose of iodine 131-labeled murine anti-tenascin antibody 81C6 (131I-81C6) injected into a surgically created resection cavity (SCRC) for the treatment of r ... Link to item Cite

Phase II study of thalidomide and daily cyclophosphamide for adults with malignant glioma.

Journal Article J Clin Oncol · July 15, 2004 1554 Background: We performed a phase II study to determine the activity and toxicity of thalidomide plus daily cyclophosphamide in patients with recurrent anaplastic astrocytomas (AA) and anaplastic oligodendrogliomas (AO). METHODS: Eligibility: adult pat ... Link to item Cite

SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility.

Journal Article Mol Cancer Ther · June 2004 Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that promotes malignant glioma invasion, angiogenesis, and immunosuppression. Antisense oligonucleotide suppression of TGF-beta(2) ligand expression has shown promise in preclinical a ... Link to item Cite

Resistance to tyrosine kinase inhibition by mutant epidermal growth factor receptor variant III contributes to the neoplastic phenotype of glioblastoma multiforme.

Journal Article Clin Cancer Res · May 1, 2004 PURPOSE: We have reported previously that tumors expressing wild-type epidermal growth factor receptor (EGFR) in a murine model are sensitive to the EGFR tyrosine kinase inhibitor gefitinib, whereas tumors expressing mutant EGFR variant III (EGFRvIII) are ... Full text Link to item Cite

Phase 1 trial of irinotecan plus BCNU in patients with progressive or recurrent malignant glioma.

Journal Article Neuro Oncol · April 2004 Irinotecan is a topoisomerase I inhibitor previously shown to be active in the treatment of malignant glioma. We now report the results of a phase 1 trial of irinotecan plus BCNU, or 1,3-bis(2-chloroethyl)-1-nitrosourea, for patients with recurrent or prog ... Full text Link to item Cite

Phase 2 trial of BCNU plus irinotecan in adults with malignant glioma.

Journal Article Neuro Oncol · April 2004 In preclinical studies, BCNU, or 1,3-bis(2-chloroethyl)-1-nitrosourea, plus CPT-11 (irinotecan) exhibits schedule-dependent, synergistic activity against malignant glioma (MG). We previously established the maximum tolerated dose of CPT-11 when administere ... Full text Link to item Cite

Heart rate variability in atrial fibrillation related to left atrial size.

Journal Article The American journal of cardiology · March 2004 The purpose of this investigation was to determine whether heart rate variability (HRV) in atrial fibrillation (AF) can be related to any echocardiographic-derived measurements of cardiac dimensions or function. AF is characterized by marked HRV. Although ... Cite

Conditions associated with ST-segment elevation.

Journal Article The New England journal of medicine · March 2004 Cite

Phase II trial of gefitinib in recurrent glioblastoma.

Journal Article J Clin Oncol · January 1, 2004 PURPOSE: To evaluate the efficacy and tolerability of gefitinib (ZD1839, Iressa; AstraZeneca, Wilmington, DE), a novel epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. PATIENTS AND METHODS: This was an op ... Full text Link to item Cite

O6-3-[131I]iodobenzylguanine: improved synthesis and further evaluation of a potential agent for imaging of alkylguanine-DNA alkyltransferase.

Journal Article Bioconjug Chem · 2004 O(6)-Benzylguanine derivatives with suitable radionuclides attached to the benzyl ring are potentially useful in the noninvasive imaging of the DNA repair protein, alkylguanine-DNA alkyltransferase (AGT). Previously, O(6)-3-[(131)I]iodobenzylguanine ([(131 ... Full text Link to item Cite

In reply

Journal Article Journal of Clinical Oncology · January 1, 2004 Full text Cite

Efficacy of intracerebral microinfusion of trastuzumab in an athymic rat model of intracerebral metastatic breast cancer.

Journal Article Clin Cancer Res · November 15, 2003 PURPOSE: The monoclonal antibody (MAb) trastuzumab (Herceptin) effectively treats HER2-overexpressing extracerebral breast neoplasms. Delivery of such macromolecule therapeutic agents to intracerebral metastases, however, is limited by the tight junctions ... Link to item Cite

Marked variability of melphalan plasma drug levels during regional hyperthermic isolated limb perfusion.

Journal Article Am J Surg · November 2003 BACKGROUND: Hyperthermic isolated limb perfusion (HILP) with melphalan as treatment for locally recurrent or in-transit malignant melanoma is frequently performed but the principle for calculating drug dosage remains poorly understood. METHODS: This study ... Full text Link to item Cite

Phase 2 study of idarubicin in pediatric brain tumors: Pediatric Oncology Group study POG 9237.

Journal Article Neuro Oncol · October 2003 Idarubicin (IDA), the 4-demethoxy analog of daunomycin, has had significant cytotoxicity in many malignancies. In previous reports, the alcohol metabolite of IDA, 4-demethoxydaunorubicinol (idarubicinol, or IDOL), had cytotoxic activity and the ability to ... Full text Link to item Cite

Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malignant brain tumors.

Journal Article J Neurooncol · October 2003 TP-38 is a recombinant chimeric targeted toxin composed of the EGFR binding ligand TGF-alpha and a genetically engineered form of the Pseudomonas exotoxin, PE-38. After in vitro and in vivo animal studies that showed specific activity and defined the maxim ... Full text Link to item Cite

Epidermal growth factor receptor VIII peptide vaccination is efficacious against established intracerebral tumors.

Journal Article Clin Cancer Res · September 15, 2003 PURPOSE: The epidermal growth factor receptor (EGFR) is often amplified and structurally rearranged in malignant gliomas and other tumors such as breast and lung, with the most common mutation being EGFRvIII. In the study described here, we tested in mouse ... Link to item Cite

The activity of camptothecin analogues is enhanced in histocultures of human tumors and human tumor xenografts by modulation of extracellular pH.

Journal Article Cancer Chemother Pharmacol · September 2003 BACKGROUND: Most solid human tumors exist in an acidic microenvironment, due in part to inefficient vasculature and a higher intrinsic rate of glycolysis. This leads to a tumor-selective pH gradient, which can be exploited therapeutically with antitumor ag ... Full text Link to item Cite

High-dose chemotherapy with autologous stem-cell rescue in children and adults with newly diagnosed pineoblastomas.

Journal Article J Clin Oncol · June 1, 2003 PURPOSE: We evaluated the usefulness of a treatment regimen that included high-dose chemotherapy (HDC) with autologous stem-cell rescue (ASCR) in patients with newly diagnosed pineoblastoma (PBL). PATIENTS AND METHODS: Twelve patients with PBL were initial ... Full text Link to item Cite

The emerging role of irinotecan (CPT-11) in the treatment of malignant glioma in brain tumors.

Journal Article Cancer · May 1, 2003 Irinotecan is a water-soluble derivative of camptothecin, an alkylator originally extracted from the Chinese tree Camptotheca acuminata. Laboratory studies have demonstrated the activity of irinotecan in a broad panel of pediatric and adult central nervous ... Full text Link to item Cite

Irinotecan: promising activity in the treatment of malignant glioma.

Journal Article Oncology (Williston Park) · May 2003 Patients with malignant glioma continue to have a dismal outcome. Those with glioblastoma multiforme, the most common type of malignant glioma, have a median survival of 40 to 60 weeks following diagnosis and only 16 to 24 weeks after recurrence. While sta ... Link to item Cite

Specific and high-level targeting of radiolabeled octreotide analogues to human medulloblastoma xenografts.

Journal Article Clin Cancer Res · May 2003 PURPOSE: The objective of this study was to determine the feasibility of exploiting the overexpression of somatostatin subtype-2 receptors (sstr(2)) on human medulloblastoma cells to develop targeted radiodiagnostics and radiotherapeutics for this disease. ... Link to item Cite

Introduction: Irinotecan in brain tumors

Journal Article Cancer · May 1, 2003 Full text Cite

Two studies evaluating irinotecan treatment for recurrent malignant glioma using an every-3-week regimen.

Journal Article Cancer · May 1, 2003 Two studies were performed to evaluate the safety, tolerability, and efficacy of irinotecan (CPT-11) in the treatment of adults with malignant glioma. Patients with progressive or recurrent malignant gliomas were enrolled. In the first study, CPT-11 was ad ... Full text Link to item Cite

Sub-classification of glioblastoma defined by comparative genomic hybridization alterations.

Conference JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY · May 1, 2003 Link to item Cite

Phase I study of temozolomide and escalating doses of oral etoposide for adults with recurrent malignant glioma.

Journal Article Cancer · April 15, 2003 BACKGROUND: Although temozolomide is active against recurrent malignant glioma, responses in many patients are modest and short-lived. Temozolomide may prove more effective in combination with other agents. Therefore, combination oral chemotherapy for thes ... Full text Link to item Cite

The coding of uniform colour figures in monkey visual cortex.

Journal Article The Journal of physiology · April 2003 Psychophysical studies indicate that perception of the colour and brightness of a surface depends on neural signals evoked by the borders of the surface rather than its interior. The visual cortex emphasizes contrast borders, but it is unclear whether colo ... Cite

Phase II trial of temozolomide in patients with progressive low-grade glioma.

Journal Article J Clin Oncol · February 15, 2003 Featured Publication PURPOSE: Temozolomide (Temodar; Schering-Plough Corp, Kenilworth, NJ) is an imidazole tetrazinone that undergoes chemical conversion to the active methylating agent 5-(3-methyltriazen-1yl)imidazole-4-carboximide under physiologic conditions. Previous studi ... Full text Link to item Cite

Prognostic value of magnetic resonance imaging-guided stereotactic biopsy in the evaluation of recurrent malignant astrocytoma compared with a lesion due to radiation effect.

Journal Article J Neurosurg · January 2003 Featured Publication OBJECT: The prognostic value of differentiating between recurrent malignant glioma and a lesion due to radiation effect by performing stereotactic biopsy has not been assessed. Thus, this study was undertaken to determine such value. METHODS: Between 1995 ... Full text Link to item Cite

Innovations in design and delivery of chemotherapy for brain tumors.

Journal Article Neuroimaging Clin N Am · November 2002 Effectiveness of chemotherapy in patients with brain tumors is hampered by the presence of the blood-brain barrier and drug resistance. In recent years, significant progress has been made in devising innovative methods of design and delivery of chemotherap ... Full text Link to item Cite

Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (iressa).

Journal Article Clin Cancer Res · November 2002 Featured Publication Iressa (ZD1839) is a p.o.-active, selective, epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) that blocks signal transduction pathways implicated in cancer cell proliferation, survival, and host-dependent processes promoting cancer gro ... Link to item Cite

A phase II study of temozolomide in patients with newly diagnosed supratentorial malignant glioma before radiation therapy.

Journal Article Neuro Oncol · October 2002 Featured Publication Temozolomide is a novel second-generation oral alkylating agent with demonstrated efficacy and safety in patients with recurrent glioblastoma multiforme (GBM) and anaplastic astrocytoma (AA). A multicenter phase II trial was conducted to determine the effi ... Full text Link to item Cite

Current options for the treatment of neoplastic meningitis.

Journal Article J Neurooncol · October 2002 Featured Publication Neoplastic meningitis, which is the diffuse involvement of the leptomeninges by infiltrating cancer cells, may be caused by many systemic tumors. The treatment options for neoplastic meningitis disease remain unsatisfactory. In this review article, we disc ... Full text Link to item Cite

Relation between Irofulven (MGI-114) systemic exposure and tumor response in human solid tumor xenografts.

Journal Article Clin Cancer Res · September 2002 Featured Publication Irofulven is a novel, small molecular weight semisynthetic compound, derived from a family of mushroom toxins known as illudins. This DNA alkylating agent has a chemical structure unlike any other chemotherapeutic agent in clinical use. The molecule is cur ... Link to item Cite

O6-benzylguanine-mediated enhancement of chemotherapy.

Journal Article Mol Cancer Ther · September 2002 Featured Publication We have previously demonstrated (A. E. Pegg, Cancer Res., 50: 6119-6129, 1990) that O6-benzylguanine (O6-BG) enhances nitrosourea, temozolomide, and cyclophosphamide activity in malignant glioma xenografts growing in athymic nude mice. More recently, we ha ... Link to item Cite

Mechanisms of resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea in human medulloblastoma and rhabdomyosarcoma.

Journal Article Mol Cancer Ther · July 2002 Featured Publication Medulloblastoma (D-341 MED) and rhabdomyosarcoma (TE-671) cell lines, which are resistant to either 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) or the combination of BCNU and O6-benzylguanine (O6-BG), were generated by serial escalation of BCNU. The activi ... Link to item Cite

Phase II study of carboplatin in children with progressive low-grade gliomas.

Journal Article J Clin Oncol · July 1, 2002 Featured Publication PURPOSE: To assess the rate of tumor response and activity of carboplatin in stabilizing the growth of progressive low-grade gliomas. PATIENTS AND METHODS: Eligible patients received carboplatin 560 mg/m(2) intravenously every 4 weeks for 1 year after maxi ... Full text Link to item Cite

Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion.

Journal Article Cancer Res · June 15, 2002 Featured Publication The gene most commonly altered in human glioblastomas is the epidermalgrowth factor receptor (EGFR). We profiled transcripts induced by mutantEGFR to better understand its role in tumor progression. The pattern found suggested enhanced tumor invasion. The ... Link to item Cite

Molecular markers of prognosis in astrocytic tumors.

Journal Article Cancer · May 15, 2002 Featured Publication BACKGROUND: Astrocytoma is a primary brain tumor that affects 20,000 Americans each year. To date, only age and histologic grade stand out as independent predictors of survival. There is now increased interest in the use of molecular markers as objective s ... Full text Link to item Cite

Management of tumor bed cysts after chemotherapeutic wafer implantation. Report of four cases.

Journal Article J Neurosurg · May 2002 Featured Publication Adjuvant use of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) wafers with surgical resection is becoming common for the treatment of malignant gliomas. Cyst formation in the tumor resection cavity is a recently described complication associated with the use ... Full text Link to item Cite

MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group.

Journal Article Arch Pathol Lab Med · May 2002 Featured Publication CONTEXT: Brain tumors are the most common solid tumor in childhood, and medulloblastoma is the most common malignant brain tumor in this age group. Cytogenetic abnormalities that have been described in childhood medulloblastoma include loss of 17p, amplifi ... Full text Link to item Cite

Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma.

Journal Article J Clin Oncol · May 1, 2002 Featured Publication PURPOSE: We conducted a phase II trial of carmustine (BCNU) plus the O(6)-alkylguanine-DNA alkyltransferase inhibitor O(6)-benzylguanine (O(6)-BG) to define the activity and toxicity of this regimen in the treatment of adults with progressive or recurrent ... Full text Link to item Cite

Phase II study of irinotecan (CPT-11) in children with high-risk malignant brain tumors: the Duke experience.

Journal Article Neuro Oncol · April 2002 Featured Publication A phase II study of irinotecan (CPT-11) was conducted at Duke University Medical Center, Durham, NC, to evaluate the activity of this agent in children with high-risk malignant brain tumors. A total of 22 children were enrolled in this study, including 13 ... Full text Link to item Cite

Comprehensive molecular cytogenetic investigation of chromosomal abnormalities in human medulloblastoma cell lines and xenograft.

Journal Article Neuro Oncol · April 2002 Featured Publication Cell lines and xenografts derived from medulloblastomas are useful tools to investigate the chromosomal changes in these tumors. Here we used G-banding, fluorescence in situ hybridization (FISH), spectral karyotyping (SKY), and comparative genomic hybridiz ... Full text Link to item Cite

Irinotecan treatment for recurrent malignant glioma using an every-3-week regimen.

Journal Article Am J Clin Oncol · April 2002 This phase II study was designed to evaluate the safety, tolerability, and efficacy of irinotecan (CPT-11) in the treatment of adults with malignant glioma. Patients with progressive or recurrent malignant gliomas were enrolled. CPT-11 was administered as ... Full text Link to item Cite

Phase II trial of murine (131)I-labeled antitenascin monoclonal antibody 81C6 administered into surgically created resection cavities of patients with newly diagnosed malignant gliomas.

Journal Article J Clin Oncol · March 1, 2002 Featured Publication PURPOSE: To assess the efficacy and toxicity of intraresection cavity (131)I-labeled murine antitenascin monoclonal antibody 81C6 and determine its true response rate among patients with newly diagnosed malignant glioma. PATIENTS AND METHODS: In this phase ... Full text Link to item Cite

Histopathologic grading of medulloblastomas: a Pediatric Oncology Group study.

Journal Article Cancer · January 15, 2002 Featured Publication BACKGROUND: Medulloblastomas are small cell embryonal tumors of the cerebellum found predominantly in children, only slightly more than half of whom survive. Predicting favorable outcome has been difficult, and improved stratification clearly is required t ... Full text Link to item Cite

Dendritic cells pulsed with a tumor-specific peptide induce long-lasting immunity and are effective against murine intracerebral melanoma.

Journal Article Neurosurgery · January 2002 Featured Publication OBJECTIVE: Dendritic cells (DCs) are specialized cells of the immune system that are capable of generating potent immune responses that are active even within the "immunologically privileged" central nervous system. However, immune responses generated by D ... Full text Link to item Cite

Synthesis and evaluation of (18)F-labeled choline analogs as oncologic PET tracers.

Journal Article J Nucl Med · December 2001 UNLABELLED: Elevated levels of choline (trimethyl-2-hydroxyethylammonium) and choline kinase (CK) activity in neoplasms have motivated the development of positron-labeled choline analogs for noninvasive detection of cancer using PET. The aim of this study ... Link to item Cite

Activity of irofulven (6-hydroxymethylacylfulvene) in the treatment of glioblastoma multiforme-derived xenografts in athymic mice.

Journal Article Cancer Chemother Pharmacol · November 2001 PURPOSE: This study was conducted to define the activity of irofulven in the treatment of a series of xenografts derived from human glioblastoma multiforme growing subcutaneously and intracranially in athymic nude mice. METHODS: Athymic mice bearing subcut ... Full text Link to item Cite

Phase I study of Gliadel wafers plus temozolomide in adults with recurrent supratentorial high-grade gliomas.

Journal Article Neuro Oncol · October 2001 Both Gliadel wafers [1,3-bis(2-chloroethyl)-1-nitrosourea] and temozolomide (TEMO) have been shown in independent studies to prolong survival of patients with recurrent malignant glioma following surgery and radiotherapy. On the basis of preclinical eviden ... Full text Link to item Cite

Therapeutic activity of the topoisomerase I inhibitor J-107088 [6-N-(1-hydroxymethyla-2-hydroxyl) ethylamino-12,13-dihydro-13-(beta-D-glucopyranosyl) -5H-indolo[2,3-a]-pyrrolo[3,4-c]-carbazole-5,7(6H)-dione]] against pediatric and adult central nervous system tumor xenografts.

Journal Article Cancer Chemother Pharmacol · September 2001 Featured Publication PURPOSE: The in vivo antitumor activity of a novel topoisomerase I inhibitor, J-107088, was tested in athymic nude mice bearing subcutaneous or intracranial pediatric and adult malignant CNS tumor-derived xenografts. METHODS: J-107088 was administered to a ... Full text Link to item Cite

Acyl derivatives of demethylpenclomedine, an antitumor-active, non-neurotoxic metabolites of penclomedine.

Journal Article Cancer Chemother Pharmacol · July 2001 PURPOSE: The purpose of this investigation was to compare the antitumor activities of a series of acyl derivatives of 4-demethylpenclomedine (DM-PEN), the major plasma metabolite of penclomedine (PEN) observed to be an active antitumor agent in vivo and no ... Full text Link to item Cite

Therapeutic activity of 7-[(2-trimethylsilyl)ethyl)]-20 (S)-camptothecin against central nervous system tumor-derived xenografts in athymic mice.

Journal Article Cancer Chemother Pharmacol · July 2001 PURPOSE: Camptothecins have emerged as an important new class of antitumor drugs. Camptothecin derivatives such as CPT-11 and topotecan are commercially available and approved for the treatment of colorectal (CPT-11) and ovarian and small-cell lung cancer ... Full text Link to item Cite

Long term response in a patient with neoplastic meningitis secondary to melanoma treated with (131)I-radiolabeled antichondroitin proteoglycan sulfate Mel-14 F(ab')(2): a case study.

Journal Article Cancer · May 1, 2001 Even with novel chemotherapeutic agents and external beam radiation therapy, the prognosis of neoplastic meningitis secondary to malignant melanoma is still dismal. The authors report a case study of a 46-year-old white female who presented with progressiv ... Link to item Cite

Serum homocysteine and stroke in atrial fibrillation.

Journal Article Ann Intern Med · February 6, 2001 Full text Link to item Cite

Inactivation of O6-alkylguanine-DNA alkyltransferase by 8-substituted O6-benzylguanine analogs in mice.

Journal Article Cancer Chemother Pharmacol · 2001 PURPOSE: The purpose of this study was to determine the usefulness of various 8-substituted O6-benzylguanine (BG) analogs as modulators of the DNA repair protein. O6-alkylguanine-DNA alkyltransferase (AGT). More specifically, the degree of inactivation of ... Full text Link to item Cite

Paclitaxel for the treatment of progressive or recurrent childhood brain tumors: a pediatric oncology phase II study.

Journal Article J Pediatr Hematol Oncol · 2001 PURPOSE: To assess the efficacy and define the toxicity of paclitaxel given at a dosage of 350 mg/m2 every 3 weeks as a 24-hour continuous infusion to children with recurrent or progressive primary brain tumors. PATIENTS AND METHODS: Seventy-three eligible ... Full text Link to item Cite

Long-term relations of personality and health: dynamisms, mechanisms, tropisms.

Journal Article J Pers · December 2000 There is now little doubt that individuals who are well-adjusted, socially stable, and well-integrated into their communities are at significantly lower risk for disease and premature mortality than those who are more unstable, impulsive, isolated, and ali ... Full text Link to item Cite

A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer.

Journal Article Oncogene · November 23, 2000 Homozygous deletions of human chromosome 9p21 occur frequently in malignant cell lines, and are also common in primary gliomas, lung cancers, and leukemias. Moving from the centromere to the telomere, this complex region encodes the tumor suppressor genes ... Full text Link to item Cite

Phase I trial results of iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with newly diagnosed malignant gliomas.

Journal Article J Clin Oncol · November 15, 2000 PURPOSE: To determine the maximum-tolerated dose (MTD) of iodine-131 ((131)I)-labeled 81C6 antitenascin monoclonal antibody (mAb) administered clinically into surgically created resection cavities (SCRCs) in malignant glioma patients and to identify any ob ... Full text Link to item Cite

Observational studies and randomized trials.

Journal Article N Engl J Med · October 19, 2000 Link to item Cite

Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.

Journal Article J Clin Oncol · October 15, 2000 PURPOSE: The major mechanism of resistance to alkylnitrosourea therapy involves the DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (AGT), which removes chloroethylation or methylation damage from the O(6) position of guanine. O(6)-benzylguanine ... Full text Link to item Cite

Carboplatin is effective therapy for young children with progressive optic pathway tumors: a Pediatric Oncology Group phase II study.

Journal Article Neuro Oncol · October 2000 The Pediatric Oncology Group conducted a phase II study to evaluate the activity of carboplatin in children 5 years or younger with progressive optic pathway tumors (OPTs). Of the 51 patients accrued to this study, 1 was not eligible because the child was ... Full text Link to item Cite

Effects of cardiac glycosides on atrial contractile dysfunction after short-term atrial fibrillation.

Journal Article Chest · October 2000 BACKGROUND: Despite a long history of use in the treatment of paroxysmal atrial fibrillation (AF), the efficacy of cardiac glycosides has not been established. If such drugs are beneficial in this condition, the general view is that the benefit must be rel ... Full text Link to item Cite

Antitumor activity of temozolomide combined with irinotecan is partly independent of O6-methylguanine-DNA methyltransferase and mismatch repair phenotypes in xenograft models.

Journal Article Clin Cancer Res · October 2000 The activity of temozolomide combined with irinotecan (CPT-11) was evaluated against eight independent xenografts (four neuroblastomas, three rhabdomyosarcomas, and one glioblastoma). In all studies, temozolomide was administered p.o. daily for 5 consecuti ... Link to item Cite

"Large cell/anaplastic" medulloblastomas: a Pediatric Oncology Group Study.

Journal Article J Neuropathol Exp Neurol · October 2000 495 medulloblastomas (MBs) from 6 Pediatric Oncology Group (POG) protocols were reviewed to assess the incidence and prognostic significance of "large cell" and "anaplastic" variants. "Large cell" medulloblastomas (LC MBs) were those with focal or diffuse, ... Full text Link to item Cite

Schedule-dependent activity of temozolomide plus CPT-11 against a human central nervous system tumor-derived xenograft.

Journal Article Clin Cancer Res · October 2000 Temozolomide, an imidazole tetrazinone, and CPT-11, a camptothecin derivative, have previously been shown to have anti-central nervous system tumor activity in laboratory and clinical studies. The current experiments were designed to evaluate the activity ... Link to item Cite

Temozolomide delivered by intracerebral microinfusion is safe and efficacious against malignant gliomas in rats.

Journal Article Clin Cancer Res · October 2000 Intracerebral microinfusion (ICM) is an innovative technique of delivering therapeutic agents throughout large portions of the brain that circumvents the blood-brain barrier, minimizes systemic toxicity, and provides a homogeneous distribution of the infus ... Link to item Cite

Coding of border ownership in monkey visual cortex.

Journal Article J Neurosci · September 1, 2000 Areas V1 and V2 of the visual cortex have traditionally been conceived as stages of local feature representations. We investigated whether neural responses carry information about how local features belong to objects. Single-cell activity was recorded in a ... Full text Link to item Cite

A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse.

Journal Article Br J Cancer · September 2000 A randomized, multicentre, open-label, phase II study compared temozolomide (TMZ), an oral second-generation alkylating agent, and procarbazine (PCB) in 225 patients with glioblastoma multiforme at first relapse. Primary objectives were to determine progre ... Full text Link to item Cite

Low-stage medulloblastoma: final analysis of trial comparing standard-dose with reduced-dose neuraxis irradiation.

Journal Article J Clin Oncol · August 2000 PURPOSE: To evaluate prospectively the effects on survival, relapse-free survival, and patterns of relapse of reduced-dose (23.4 Gy in 13 fractions) compared with standard-dose (36 Gy in 20 fractions) neuraxis irradiation in patients 3 to 21 years of age w ... Full text Link to item Cite

Temozolomide and treatment of malignant glioma.

Journal Article Clin Cancer Res · July 2000 Malignant gliomas (glioblastoma multiforme and anaplastic astrocytoma) occur more frequently than other types of primary central nervous system tumors, having a combined incidence of 5-8/100,000 population. Even with aggressive treatment using surgery, rad ... Link to item Cite

Comparative genetic patterns of glioblastoma multiforme: potential diagnostic tool for tumor classification.

Journal Article Neuro Oncol · July 2000 Cytogenetic and molecular genetic studies of glioblastoma multiforme (GBM) have shown that the most frequent alterations are gains of chromosome 7, losses of 9p loci and chromosome 10, and gene amplification, primarily of the epidermal growth factor recept ... Full text Link to item Cite

Temozolomide in early stages of newly diagnosed malignant glioma and neoplastic meningitis

Journal Article Seminars in Oncology · June 30, 2000 Temozolomide is a novel, oral, second-generation alkylating agent. Preclinical and phase I/II studies have demonstrated its efficacy against newly diagnosed high-grade glioma and anaplastic astrocytoma, its antineoplastic effect is accompanied by quality o ... Cite

Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors.

Journal Article Proc Natl Acad Sci U S A · June 20, 2000 The epidermal growth factor receptor (EGFR) is often amplified and rearranged structurally in tumors of the brain, breast, lung, and ovary. The most common mutation, EGFRvIII, is characterized by an in-frame deletion of 801 base pairs, resulting in the gen ... Full text Link to item Cite

Temozolomide in early stages of newly diagnosed malignant glioma and neoplastic meningitis.

Journal Article Semin Oncol · June 2000 Temozolomide is a novel, oral, second-generation alkylating agent. Preclinical and phase I/II studies have demonstrated its efficacy against newly diagnosed high-grade glioma and anaplastic astrocytoma. Its antineoplastic effect is accompanied by quality o ... Link to item Cite

A detrimental effect of a combined chemotherapy-radiotherapy approach in children with diffuse intrinsic brain stem gliomas?

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2000 PURPOSE: To compare the proportion of patients that survive at least 1 year following treatment with hyper-fractionated radiotherapy (HRT) to a dose of 70.2 Gy on Pediatric Oncology Group (POG) study #8495 with that of patients treated with similar radioth ... Full text Link to item Cite

Characterization of chromosome 17 abnormalities in medulloblastomas.

Journal Article Acta Neuropathol · April 2000 Loss of portions of chromosome 17p, usually through the formation of i(17qp) is a well-known finding in medulloblastomas. Loss of heterozygosity (LOH) studies, however, occasionally demonstrate loss of the more distal portions of 17p, a pattern which is mo ... Full text Link to item Cite

Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models.

Journal Article Clin Cancer Res · March 2000 The antitumor activity of the methylating agent temozolomide has been evaluated against a panel of 17 xenografts derived from pediatric solid tumors. Temozolomide was administered p.o. daily for five consecutive days at a dose level of 66 mg/kg. Courses of ... Link to item Cite

Dosimetry and dose-response relationships in newly diagnosed patients with malignant gliomas treated with iodine-131-labeled anti-tenascin monoclonal antibody 81C6 therapy.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2000 PURPOSE: The objective of this study was to perform the dosimetry and evaluate the dose-response relationships in newly diagnosed patients with malignant brain tumors treated by direct injections of (131)I-labeled 81C6 monoclonal antibody (MAb) into surgic ... Full text Link to item Cite

Comparing personality scales across time: an illustrative study of validity and consistency in life-span archival data.

Journal Article J Pers · February 2000 The goals of this study were: (a) to examine whether personality scales, meaningful in contemporary terms, could be derived from archival data; and (b) to use these scales to aid our understanding of the relation of personality to mortality. NEO PI-R data ... Full text Link to item Cite

Evaluation of pre-radiotherapy cyclophosphamide in patients with newly diagnosed glioblastoma multiforme. Writing Committee for The Brain Tumor Center at Duke.

Journal Article J Neurooncol · 2000 Cyclophosphamide is an alkylating agent that has shown activity in the treatment of pediatric brain tumors, including high-grade gliomas. This study was designed to evaluate the response of patients with newly diagnosed glioblastoma multiforme to pre-radio ... Full text Link to item Cite

Oral methotrexate for recurrent brain tumors in children: a Pediatric Oncology Group study.

Journal Article J Pediatr Hematol Oncol · 2000 PURPOSE: Children with recurrent or progressive central nervous system (CNS) tumors have an unfavorable prognosis. Based on Pediatric Oncology Group (POG) institutional pilot data, low-dose oral methotrexate (MTX) was studied. METHODS: Eight dosages of MTX ... Full text Link to item Cite

The comparative effects of drive and test stimulus intensity on myocardial excitability and vulnerability.

Journal Article Pacing Clin Electrophysiol · January 2000 The number and intensity of stimuli that set basic cycle length in cardiac electrophysiological studies can influence the electrical properties assessed by extrastimuli. The relative contribution of drive (S1) and test (S2) stimulus intensity in defining m ... Full text Link to item Cite

Representation of stereoscopic edges in monkey visual cortex.

Journal Article Vision Res · 2000 Form perception in random-dot stereograms is based on information that resides in the correlation between the two images, but is not present in either image alone. We have studied the coding of stereoscopic figures in the neural activity of areas V1 and V2 ... Full text Link to item Cite

O6-benzylguanine-mediated enhancement of nitrosourea activity in Mer- central nervous system tumor xenografts--implications for clinical trials.

Journal Article Cancer Chemother Pharmacol · 2000 PURPOSE: To evaluate the role of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine (O6-BG) in the treatment of both Mer+ and Mer- tumors. METHODS: The effect of pretreatment with O6-BG on the activity of BCNU against Mer- human central nerv ... Full text Link to item Cite

Schedule-dependent activity of irinotecan plus BCNU against malignant glioma xenografts.

Journal Article Cancer Chemother Pharmacol · 2000 PURPOSE: To further evaluate the activity of irinotecan (CPT-11) plus 1,3-bis-(chloroethyl)-1-nitrosourea (BCNU) in the treatment of central nervous system tumor-derived xenografts in athymic nude mice. METHODS: We report studies evaluating the schedule-de ... Full text Link to item Cite

Radiolabeled guanine derivatives for the in vivo mapping of O(6)-alkylguanine-DNA alkyltransferase: 6-(4-[(18)F]Fluoro-benzyloxy)-9H-purin-2-ylamine and 6-(3-[(131)I]Iodo-benzyloxy)-9H-purin-2-ylamine.

Journal Article Bioconjug Chem · 2000 Two radiolabeled analogues of 6-benzyloxy-9H-purin-2-ylamine (O(6)-benzylguanine; BG) potentially useful in the in vivo mapping of O(6)-alkylguanine-DNA alkyltransferase (AGT) were synthesized. Fluorine-18 labeling of the known 6-(4-fluoro-benzyloxy)-9H-pu ... Full text Link to item Cite

O6-benzylguanine-mediated enhancement of nitrosourea activity in Mer- central nervous system tumor xenografts - Implications for clinical trials

Journal Article Cancer Chemotherapy and Pharmacology · 2000 Purpose: To evaluate the role of 1,3-bis(2-chloroethyl)-l-nitrosourea (BCNU) plus O6-benzylguanine (O6-BG) in the treatment of both Mer+ and Mer- tumors. Methods: The effect of pretreatment with O6-BG on the activity of BCNU against Mer- human central nerv ... Cite

Age-related changes in the associations of social network ties with mortality risk.

Journal Article Psychol Aging · December 1999 Age-related changes in the associations of social network ties with mortality risk were investigated using data from the Terman Life-Cycle Study (L. M. Terman, 1925; L. M. Terman & M. H. Oden, 1947, 1959). Marital status, number of living children, number ... Full text Link to item Cite

Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor Group.

Journal Article J Clin Oncol · September 1999 PURPOSE: To determine the antitumor efficacy and safety profile of temozolomide in patients with malignant astrocytoma at first relapse. PATIENTS AND METHODS: This open-label, multicenter, phase II trial enrolled 162 patients (intent-to-treat [ITT] populat ... Full text Link to item Cite

Regional treatment of epidermal growth factor receptor vIII-expressing neoplastic meningitis with a single-chain immunotoxin, MR-1.

Journal Article Clin Cancer Res · September 1999 The incidence of neoplastic meningitis is on the rise. Neoplastic meningitis can result from a direct seeding of the neuraxis by primary brain tumors or by hematogeneous spread of systemic solid tumors. A frequent genetic alteration in primary brain tumors ... Link to item Cite

Molecular genetic aspects of oligodendrogliomas including analysis by comparative genomic hybridization.

Journal Article Am J Pathol · August 1999 Oligodendroglial neoplasms are a subgroup of gliomas with distinctive morphological characteristics. In the present study we have evaluated a series of these tumors to define their molecular profiles and to determine whether there is a relationship between ... Full text Link to item Cite

Verapamil prolongs atrial fibrillation by evoking an intense sympathetic neurohumoral effect.

Journal Article Journal of investigative medicine : the official publication of the American Federation for Clinical Research · July 1999 BackgroundVerapamil is an effective drug to slow ventricular rate in atrial fibrillation (AF). Clinically, however, i.v. verapamil enhances AF despite experimental evidence suggesting favorable effects of the drug on AF-induced electrical remodeli ... Cite

Topotecan for the treatment of recurrent or progressive central nervous system tumors - a pediatric oncology group phase II study.

Journal Article J Neurooncol · May 1999 Topotecan was studied as a 72 h infusion given every 3 weeks. Treatment began at a dose of 1.0 mg/m2/day and was increased to 1.25 mg/m2/day after the first 6 patients tolerated this higher dose without excessive toxicities. Eighty-eight evaluable children ... Full text Link to item Cite

Treatment of neoplastic meningitis with intrathecal temozolomide.

Journal Article Clin Cancer Res · May 1999 Neoplastic meningitis (NM) results from leptomeningeal dissemination of cancers arising within the central nervous system or metastasizing to the leptomeninges from systemic neoplasms. The inability to produce therapeutic drug levels intrathecally (i.t.) w ... Link to item Cite

Irinotecan therapy in adults with recurrent or progressive malignant glioma.

Journal Article J Clin Oncol · May 1999 PURPOSE: To determine the activity, toxicity, and pharmacokinetics of irinotecan (CPT-11, Camptosar; Pharmacia & Upjohn, Kalamazoo, MI) in the treatment of adults with progressive, persistent, or recurrent malignant glioma. PATIENTS AND METHODS: Patients w ... Full text Link to item Cite

Dosimetry of 131I-labeled 81C6 monoclonal antibody administered into surgically created resection cavities in patients with malignant brain tumors.

Journal Article J Nucl Med · April 1999 UNLABELLED: The objective of this study was to perform the dosimetry of 131I-labeled 81C6 monoclonal antibody (MAb) in patients with recurrent malignant brain tumors, treated by direct injections of MAb into surgically created resection cavities (SCRCs). M ... Link to item Cite

There is no role for hyperfractionated radiotherapy in the management of children with newly diagnosed diffuse intrinsic brainstem tumors: results of a Pediatric Oncology Group phase III trial comparing conventional vs. hyperfractionated radiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 1999 PURPOSE: In June 1992, POG began accrual to a phase III study, POG-9239, designed to compare the time to disease progression, overall survival, and toxicities observed in children with newly diagnosed brainstem tumor treated with 100 mg/m2 of infusional ci ... Full text Link to item Cite

Topotecan treatment of adults with primary malignant glioma. The Brain Tumor Center at Duke.

Journal Article Cancer · March 1, 1999 BACKGROUND: Topotecan activity was evaluated for the treatment of malignant glioma. METHODS: Sixty-three patients with newly diagnosed (n = 25) or recurrent (n = 38) malignant glioma were treated with topotecan [AU: Please verify all dosages here and throu ... Link to item Cite

Smoothing bandwidth selection for response latency estimation.

Journal Article J Neurosci Methods · February 1, 1999 Stimulus response latency is the delay between stimulus onset and the evoked modulation in neural activity. A common technique to estimate latencies involves binning the spike arrival times to form a peri-stimulus histogram. This histogram is smoothed usin ... Full text Link to item Cite

Diagnostic markers in paediatric medulloblastoma: a Paediatric Oncology Group Study.

Journal Article Histopathology · February 1999 AIMS: We have reviewed immunohistochemically 17 paediatric medulloblastomas in order to determine if correlations exist that might be useful in subclassifying these tumours. METHODS AND RESULTS: The patient group included 11 children who had died (mean sur ... Full text Link to item Cite

Expression of p53 and pRb in bladder and prostate cancers of patients having both cancers.

Journal Article Anticancer Res · 1999 Evidence has been presented that tumor suppressor genes p53 and Rb play a crucial role in the development of both human prostate and bladder cancer. Patients with either cancer are at an increased risk for developing the other malignancy as compared to the ... Link to item Cite

Cyclophosphamide for the treatment of progressive low-grade astrocytoma: a Pediatric Oncology Group phase II Study.

Journal Article J Pediatr Hematol Oncol · 1999 PURPOSE: Results of a phase II trial of cyclophosphamide (CPM) for children with progressive low-grade astrocytoma are reported. PATIENTS AND METHODS: Fifteen patients with a median age of 39 months (range, 2 to 71) were included in this study. The tumors ... Full text Link to item Cite

Lack of evidence for a polymorphism at codon 160 of human O6-alkylguanine-DNA alkyltransferase gene in normal tissue and cancer.

Journal Article Clin Cancer Res · January 1999 O6-benzylguanine (BG) is a potent, specific inactivator of the DNA repair protein O6-alkylguanine-DNA alkyltransferase (AGT), which enhances sensitivity to nitrosoureas in cells and tumor-bearing animals. BG is presently undergoing clinical trials for deve ... Link to item Cite

Color filling-in under steady fixation: behavioral demonstration in monkeys and humans.

Journal Article Perception · 1999 Color filling-in is a phenomenon in which the color of an object appears to be filled-in by the color of the surrounding field. We have studied the question of whether monkeys perceive color filling-in with near-foveal stimuli under steady fixation. Two mo ... Full text Link to item Cite

Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase.

Journal Article Cancer Chemother Pharmacol · 1999 PURPOSE: The human medulloblastoma cell line D283 Med (4-HCR), a line resistant to 4-hydroperoxycyclophosphamide (4-HC), displays enhanced repair of DNA interstrand crosslinks induced by phosphoramide mustard. D283 Med (4-HCR) cells are cross-resistant to ... Full text Link to item Cite

Multiple DNA repair mechanisms and alkylator resistance in the human medulloblastoma cell line D-283 Med (4-HCR).

Journal Article Cancer Chemother Pharmacol · 1999 PURPOSE: We have previously reported preferential repair of DNA interstrand crosslinks in the 4-hydroperoxycyclophosphamide-resistant human medulloblastoma cell line D-283 Med (4-HCR). We now report further studies that explored the potential mechanisms un ... Full text Link to item Cite

Intrathecal busulfan treatment of human neoplastic meningitis in athymic nude rats.

Journal Article J Neurooncol · 1999 The current study was designed to evaluate the toxicity and activity of Spartaject Busulfan, a microcrystalline preparation of busulfan, following its intrathecal administration into a nude rat model of human neoplastic meningitis. Animals were treated thr ... Full text Link to item Cite

Temozolomide

Journal Article CNS Drugs · January 1, 1999 Full text Cite

Gliomas of the optic nerve in children and adults.

Journal Article LABORATORY INVESTIGATION · January 1, 1999 Link to item Cite

DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma.

Journal Article J Clin Oncol · December 1998 PURPOSE: We evaluated the response to Temodal (Schering-Plough Research Institute, Kenilworth, NJ) of patients with newly diagnosed malignant glioma, as well as the predictive value of quantifying tumor DNA mismatch repair activity and O6-alkylguanine-DNA ... Full text Link to item Cite

Preclinical and clinical results with irinotecan: Extending principles learned in model systems to clinical trials design

Journal Article ONCOLOGY · November 24, 1998 Clinical results with irinotecan (CPT-11 [Camptosar]) and other camptothecin derivatives in various cancers, although encouraging, have fallen short of the expectations predicted by preclinical models. One proposed explanation for this is that preclinical ... Cite

Gliomas.

Journal Article Eur J Cancer · November 1998 Full text Link to item Cite

Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma.

Journal Article J Clin Oncol · November 1998 PURPOSE: The major mechanism of resistance to alkylnitrosourea therapy is the DNA repair protein O6-alkylguanine-DNA alkyltransferase (AGT), which removes chlorethylation or methylation damage from the O6-position of guanine. O6-benzylguanine (O6-BG) is an ... Full text Link to item Cite

Estimating stimulus response latency.

Journal Article J Neurosci Methods · September 1, 1998 Stimulus response latency is the delay in the onset of stimulus-evoked neuronal activity. We develop maximum likelihood and least squares estimators of stimulus response latency and present a comparison of the performance of these methods with estimators c ... Full text Link to item Cite

Second malignancies in young children with primary brain tumors following treatment with prolonged postoperative chemotherapy and delayed irradiation: a Pediatric Oncology Group study.

Journal Article Ann Neurol · September 1998 Between 1986 and 1990, the Pediatric Oncology Group conducted a study in which 198 children younger than 3 years of age with malignant brain tumors were treated with prolonged postoperative chemotherapy in an effort to delay irradiation and reduce long-ter ... Full text Link to item Cite

Atypical teratoid/rhabdoid tumor of the central nervous system: a highly malignant tumor of infancy and childhood frequently mistaken for medulloblastoma: a Pediatric Oncology Group study.

Journal Article Am J Surg Pathol · September 1998 Fifty-five patients with atypical teratoid/rhabdoid tumors of the central nervous system were studied to define the clinical and pathologic features of this newly described neoplasm. The lesion occurred primarily in children younger than 2 (mean age at dia ... Full text Link to item Cite

Extending principles learned in model systems to clinical trials design.

Journal Article Oncology (Williston Park) · August 1998 Clinical results with irinotecan (CPT-11 [Camptosar]) and other camptothecin derivatives in various cancers, although encouraging, have fallen short of the expectations predicted by preclinical models. One proposed explanation for this is that preclinical ... Link to item Cite

Treatment of adults with progressive oligodendroglioma with carboplatin (CBDCA): preliminary results. Writing Committee for The Brain Tumor Center at Duke.

Journal Article Med Pediatr Oncol · July 1998 BACKGROUND: Exploration of the role of chemotherapy in the treatment of low grade glioma, including oligodendroglioma, has been limited to the pediatric population, reflecting the sensitivity of young patients to radiation-induced toxicity and a desire to ... Full text Link to item Cite

Iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with recurrent malignant gliomas: phase I trial results.

Journal Article J Clin Oncol · June 1998 PURPOSE: To determine the maximum-tolerated dose (MTD) of iodine 131 (131I)-labeled 81C6 monoclonal antibody (mAb) in brain tumor patients with surgically created resection cavities (SCRCs) and to identify any objective responses to this treatment. METHODS ... Full text Link to item Cite

Analysis of DNA mismatch repair proteins in human medulloblastoma.

Journal Article Clin Cancer Res · June 1998 During replication, the primary function of the eukaryotic DNA mismatch repair (MMR) system is to recognize and correct mismatched base pairs within the DNA helix. Deficiencies in MMR have been reported previously in cases of hereditary nonpolyposis colore ... Link to item Cite

Neuropsychologic functioning of survivors of childhood medulloblastoma randomized to receive conventional or reduced-dose craniospinal irradiation: a Pediatric Oncology Group study.

Journal Article J Clin Oncol · May 1998 PURPOSE: The purpose of this study was to test the hypothesis that survivors of medulloblastoma who were younger at diagnosis and those who received standard-dose cranial irradiation (SRT) of 36 Gy would have a lower performance on standardized tests of co ... Full text Link to item Cite

Phase II study of carboplatin (CBDCA) in progressive low-grade gliomas.

Journal Article Neurosurg Focus · April 15, 1998 In this study, the authors sought to investigate the response rate and toxicity of carboplatin in patients with progressive low-grade glioma (LGG). Thirty-two patients with progressive LGG were treated with carboplatin at a dosage of 560 mg/m(2). Treatment ... Full text Link to item Cite

Prognostic factors in infants and very young children with intracranial ependymomas.

Journal Article Pediatr Neurosurg · April 1998 The Pediatric Oncology Group (1986-1990) conducted a study in which 48 children <3 years of age with intracranial ependymomas were treated with prolonged postoperative chemotherapy (CT) and delayed RT. Thirty-one children, 0-23 months of age at diagnosis ( ... Full text Link to item Cite

Activity of high-dose cyclophosphamide in the treatment of childhood malignant gliomas.

Journal Article Med Pediatr Oncol · February 1998 Seventeen patients less than or equal to 20 years of age with newly diagnosed (n = 10) or recurrent (n = 7) malignant gliomas (anaplastic astrocytoma and glioblastoma multiforme) were treated with cyclophosphamide in association with hematopoietic cytokine ... Full text Link to item Cite

Therapeutic efficacy of vinorelbine against pediatric and adult central nervous system tumors.

Journal Article Cancer Chemother Pharmacol · 1998 PURPOSE: The activity of vinorellbine, a new semisynthetic vinca alkaloid, was evaluated against a battery of human tumor xenografts derived from adult and pediatric CNS malignancies. METHODS: Tumors included adult high-grade gliomas (D-54 MG, D-245 MG), c ... Full text Link to item Cite

Enhancement of irinotecan (CPT-11) activity against central nervous system tumor xenografts by alkylating agents.

Journal Article Cancer Chemother Pharmacol · 1998 Two major obstacles in the treatment of patients with central nervous system malignancies are drug resistance and host toxicity. The goal of combination chemotherapy is to achieve therapeutic effects that are more favorable than using a single drug alone, ... Full text Link to item Cite

PTEN gene mutations are seen in high-grade but not in low-grade gliomas.

Journal Article Cancer Res · October 1, 1997 The PTEN gene, located on 10q23, has recently been implicated as a candidate tumor suppressor gene in brain, breast and prostate tumors. In the present study, 123 brain tumors, including various grades and histological types of gliomas occurring in childre ... Link to item Cite

Chromosomal characteristics of childhood brain tumors.

Journal Article Cancer Genet Cytogenet · September 1997 In the present cytogenetic analysis of 116 pediatric brain tumors, chromosomal abnormalities were demonstrated in 44 cases, 48 cases revealed only 46,XX or 46,XY cells, and 24 cases were nonproductive. In contrast to studies of adult brain tumors in which ... Full text Link to item Cite

Parental divorce: effects on individual behavior and longevity.

Journal Article J Pers Soc Psychol · August 1997 Using an archival prospective design, the authors studied associations among parental divorce occurring during participants' childhood, adult psychosocial mediators, and mortality over the life span of a subgroup of participants (N = 1,261) in the Terman L ... Full text Link to item Cite

Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft.

Journal Article Cancer Res · July 15, 1997 A methylator-resistant human glioblastoma multiforme xenograft, D-245 MG (PR), in athymic nude mice was established by serially treating the parent xenograft D-245 MG with procarbazine. D-245 MG xenografts were sensitive to procarbazine, temozolomide, N-me ... Link to item Cite

Modulation of melphalan resistance in glioma cells with a peripheral benzodiazepine receptor ligand-melphalan conjugate.

Journal Article J Med Chem · May 23, 1997 Peripheral benzodiazepine receptors (PBRs) are located on the outer membrane of mitochondria, and their density is increased in brain tumors. Thus, they may serve as a unique intracellular and selective target for antineoplastic agents. A PBR ligand-melpha ... Full text Link to item Cite

Malignant supratentorial glial-neuronal neoplasms: report of two cases and review of the literature.

Journal Article Arch Pathol Lab Med · May 1997 OBJECTIVE: Malignant neoplasms exhibiting mixed populations of neuronal and glial cells occurring in the cerebral hemispheres of young adults and children are well recognized, but rare. A confusing array of diagnostic terms has arisen. We describe two pati ... Link to item Cite

High-dose chemotherapy with autologous stem-cell rescue in patients with recurrent and high-risk pediatric brain tumors.

Journal Article J Clin Oncol · May 1997 PURPOSE: We treated 49 patients with recurrent or poor-prognosis CNS malignancies with high-dose chemotherapy regimens followed by autologous marrow rescue with or without peripheral-blood stem-cell augmentation to determine the toxicity of and event-free ... Full text Link to item Cite

False positive images in the follow-up of patients with brain tumors.

Journal Article Med Pediatr Oncol · February 1997 In recent years, major advances in the diagnosis and treatment of patients with brain tumors have been seen. Today, evaluation of the central nervous system almost always includes magnetic resonance imaging (MRI). The appearance of a new lesion on the MRI ... Full text Link to item Cite

Erratum: (Cancer Research (July 15, 1997) (2933-2936))

Journal Article Cancer Research · January 1, 1997 Cite

Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against pediatric and adult central nervous system tumor xenografts.

Journal Article Cancer Chemother Pharmacol · 1997 Therapy of patients with malignant central nervous system tumors is frequently unsuccessful, reflecting limitations of current surgical, radiotherapeutic, and pharmacotherapeutic treatments. The camptothecin derivative irinotecan (CPT-11) has been shown to ... Full text Link to item Cite

L-amino acid oxidase (LOX) modulation of melphalan activity against intracranial glioma.

Journal Article Cancer Chemother Pharmacol · 1997 These studies evaluated the efficacy of sequential pretreatment with L-amino acid oxidase (LOX) and LOX antiserum in the modulation of melphalan activity against intracranial glioma in athymic nude mice. LOX produced statistically significant (P < 0.01) de ... Full text Link to item Cite

Characterization of the mechanisms of busulfan resistance in a human glioblastoma multiforme xenograft.

Journal Article Cancer Chemother Pharmacol · 1997 Busulfan is an alkylating agent commonly used in the treatment of chronic myelogenous leukemia and in combination with cyclophosphamide in preparation for allogeneic bone marrow transplantation. Serial treatment of a childhood high-grade glioma xenograft ( ... Full text Link to item Cite

Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea.

Journal Article Cancer Chemother Pharmacol · 1997 The prognosis for patients with malignant gliomas continues to be dismal. The high degree of resistance of gliomas to nitrosourea-based chemotherapy is one major factor in poor treatment outcome. The identification of O6-alkylguanine-DNA alkyltransferase ( ... Full text Link to item Cite

Zones of atrial vulnerability. Relationships to basic cycle length.

Journal Article Circulation · September 15, 1996 BACKGROUND: Bradycardia is commonly found in individuals at risk for paroxysmal atrial fibrillation (AF). However, a clear relationship between lengthening of basic cyclic length (BCL) and AF has not been demonstrated. METHODS AND RESULTS: In 20 open-chest ... Full text Link to item Cite

Monitoring of neoadjuvant therapy response of soft-tissue and musculoskeletal sarcoma using fluorine-18-FDG PET.

Journal Article J Nucl Med · September 1996 UNLABELLED: The purpose of this study was to investigate the potential role of FDG-PET in the monitoring of neoadjuvant therapy of soft-tissue and musculoskeletal sarcomas. METHODS: Nine patients were studied. Neoadjuvant therapy consisted of either chemot ... Link to item Cite

Is there a correlation between duration of presenting symptoms and stage of medulloblastoma at the time of diagnosis?

Journal Article Cancer · August 15, 1996 BACKGROUND: Does a "delay in diagnosis" lead to a child being diagnosed with advanced stage as opposed to early stage medulloblastoma? Correlation between the duration of a patient's presenting symptoms and stage at diagnosis was examined. METHODS: The pop ... Full text Link to item Cite

Evaluation of meta-[211At]astatobenzylguanidine in an athymic mouse human neuroblastoma xenograft model.

Journal Article Nucl Med Biol · August 1996 A paired-label biodistribution was performed in athymic mice bearing SK-N-SH human neuroblastoma xenografts to compare the tissue uptake of meta-[211At]astatobenzylguanidine ([211At]MABG) and [131I]MIBG. Significantly higher (p < 0.05) uptake of [211At]MAB ... Full text Link to item Cite

Successful treatment of childhood pilocytic astrocytomas metastatic to the leptomeninges with high-dose cyclophosphamide.

Journal Article Med Pediatr Oncol · July 1996 Leptomeningeal dissemination of childhood pilocytic astrocytoma (PA) is a rare event with little information available regarding therapy. We report here four children with disseminated PA whom we treated with high doses of cyclophosphamide with clinical be ... Full text Link to item Cite

Response of recurrent medulloblastoma to low-dose oral etoposide.

Journal Article J Clin Oncol · June 1996 PURPOSE: The outcome for patients with recurrent medulloblastoma has historically been poor, with most patients dying of disseminated disease. Here, we report on seven patients with recurrent medulloblastoma, most heavily pretreated with a variety of chemo ... Full text Link to item Cite

Intrathecal 131I-labeled antitenascin monoclonal antibody 81C6 treatment of patients with leptomeningeal neoplasms or primary brain tumor resection cavities with subarachnoid communication: phase I trial results.

Journal Article Clin Cancer Res · June 1996 We aimed to determine the maximum tolerated dose (MTD) of 131I-labeled 81C6 in patients with leptomeningeal neoplasms or brain tumor resection cavities with subarachnoid communication and to identify any objective responses. 81C6 is a murine IgG monoclonal ... Link to item Cite

Treatment of patients with pineoblastoma with high dose cyclophosphamide.

Journal Article Med Pediatr Oncol · June 1996 The outcome for patients with pineoblastoma has historically been very poor, with most patients dying of disseminated disease despite irradiation. Furthermore, the low incidence of this tumor has hindered progress toward defining better treatment strategie ... Full text Link to item Cite

Localisation of [131I]MIBG in nude mice bearing SK-N-SH human neuroblastoma xenografts: effect of specific activity.

Journal Article Br J Cancer · May 1996 The biodistribution of no-carrier-added (n.c.a.) meta-[131I]iodobenzylguanidine ([131I]MIBG) and that prepared by the standard isotopic exchange method were compared in athymic mice bearing SK-N-SH human neuroblastoma xenografts. No advantage in tumour upt ... Full text Open Access Link to item Cite

Production and characterization of two ependymoma xenografts.

Journal Article J Neuropathol Exp Neurol · May 1996 Childhood ependymomas exhibit epidemiologic, anatomic, histologic, and biologic features and distinguish them from other gliomas. Because of their propensity to grow in functionally sensitive regions of the brain, adequate tumor sampling for basic and ther ... Full text Link to item Cite

Marital history at midlife as a predictor of longevity: alternative explanations to the protective effect of marriage.

Journal Article Health Psychol · March 1996 The association between marital history at midlife (in 1950) and mortality (as of 1991) was studied in a group of intelligent, educated men and women (N = 1,077) who participated in the Terman Life-Cycle Study initiated by Lewis Terman in 1921. Results con ... Full text Link to item Cite

High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.

Journal Article J Med Chem · February 16, 1996 A series of 7,8-dialkylpyrrolo[3,2-f]quinazolines were prepared as inhibitors of dihydrofolate reductase (DHFR). On the basis of an apparent inverse relationship between compound size and antifungal activity, the compounds were designed to be relatively sm ... Full text Link to item Cite

Successful desensitization to carboplatin in patients with systemic hypersensitivity reactions.

Journal Article Med Pediatr Oncol · February 1996 Carboplatin is the drug of choice for the treatment of nonresectable astrocytomas in children, but patients who are intolerant may require cranial irradiation which is associated with significant morbidity. Hypersensitivity reactions, including urticaria, ... Full text Link to item Cite

Long term survivors of childhood brain stem gliomas treated with hyperfractionated radiotherapy. Clinical characteristics and treatment related toxicities. The Pediatric Oncology Group.

Journal Article Cancer · February 1, 1996 BACKGROUND: Over the past decade, the principal focus of research in pediatric brain stem gliomas has been on the use of hyperfractionated radiotherapy (HRT). The purpose of this study was to evaluate the clinical characteristics and treatment related toxi ... Full text Link to item Cite

High-dose melphalan and cyclophosphamide with autologous bone marrow rescue for recurrent/progressive malignant brain tumors in children: a pilot pediatric oncology group study.

Journal Article J Clin Oncol · February 1996 PURPOSE: To determine the maximum-tolerated dose of cyclophosphamide (CTX) when administered sequentially with melphalan 60 mg/m2/d for 3 days, followed by autologous bone marrow rescue (ABMR), in children with recurrent or progressive malignant brain tumo ... Full text Link to item Cite

Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea.

Journal Article Biochemistry · January 30, 1996 In this study, we investigated the role of ubiquitination in the disposition of the inactivated O6-methylguanine-DNA methyltransferase (MGMT) protein in human (HT-29 and CEM) and murine (ts85) tumor cells. Using a combination of immunoprecipitation and imm ... Full text Link to item Cite

Carboplatin pharmacokinetics in young children with brain tumors.

Journal Article Cancer Chemother Pharmacol · 1996 PURPOSE: The pharmacokinetic parameters and maximal tolerated systemic exposure were determined for carboplatin in young children given in combination with cyclophosphamide and etoposide. PATIENTS AND METHODS: Carboplatin was administered as part of a mult ... Full text Link to item Cite

Is birth order associated with adult mortality?

Journal Article Ann Epidemiol · January 1996 The objective of this study was to determine whether birth order is associated with total or cause-specific adult mortality and whether the association differed by sex, was confounded by age, number of siblings, or socioeconomic status, or was mediated by ... Full text Link to item Cite

Treatment of infants with malignant gliomas: the Pediatric Oncology Group experience.

Journal Article J Neurooncol · 1996 Although survivals of infants with malignant brain tumors are worse than any other age group, one possible exception to this rule are the malignant gliomas. Eighteen children less than 3 years of age with malignant gliomas (glioblastoma multiforme, anaplas ... Full text Link to item Cite

Fabrication and testing of a device capable of reducing the incidence of ventricular shunt promoted metastasis.

Journal Article J Neurooncol · January 1996 PURPOSE/OBJECTIVE: Some malignant brain tumors shed cells into the cerebrospinal fluid (CSF). These tumors may implant throughout the neuroaxis via the CSF. With the placement of a ventriculoperitoneal (VP) or ventriculoatrial (VA) shunt, tumor cells free- ... Full text Link to item Cite

Repair analysis of 4-hydroperoxycyclophosphamide-induced DNA interstrand crosslinking in the c-myc gene in 4-hydroperoxycyclophosphamide-sensitive and -resistant medulloblastoma cell lines.

Journal Article Cancer Chemother Pharmacol · 1996 Cyclophosphamide is one of the most active agents in the treatment of medulloblastoma. However, development of resistance to this alkylator frequently occurs and is the harbinger of tumor progression and death. In order to understand the biochemical basis ... Full text Link to item Cite

Enhancement of melphalan activity by inhibition of DNA polymerase-alpha and DNA polymerase-beta.

Journal Article Cancer Chemother Pharmacol · 1996 Our previous studies exploring melphalan resistance in the human rhabdomyosarcoma xenograft TE-671 MR revealed elevation of DNA polymerase-alpha and DNA polymerase-beta. The present study evaluated the alteration of melphalan activity in TE-671 (melphalan- ... Full text Link to item Cite

Microsatellite analysis of childhood brain tumors.

Journal Article Genes Chromosomes Cancer · January 1996 Loss of heterozygosity at specific chromosomal locations has been taken as evidence of a tumor suppressor gene located in that area. We performed a genomic allelotyping study on 46 childhood brain tumors of different histopathological types in order to ide ... Full text Link to item Cite

A structural basis for a phosphoramide mustard-induced DNA interstrand cross-link at 5'-d(GAC).

Journal Article Proc Natl Acad Sci U S A · December 19, 1995 Phosphoramide mustard-induced DNA interstrand cross-links were studied both in vitro and by computer simulation. The local determinants for the formation of phosphoramide mustard-induced DNA interstrand cross-links were defined by using different pairs of ... Full text Link to item Cite

Efficacy of compartmental administration of immunotoxin LMB-1 (B3-LysPE38) in a rat model of carcinomatous meningitis.

Journal Article Clin Cancer Res · December 1995 LMB-1 (B3-LysPE38) is an immunotoxin composed of the tumor-reactive monoclonal antibody B3 and a genetically engineered form of Pseudomonas exotoxin. Monoclonal antibody B3 reacts with a carbohydrate epitope that is found on a number of solid tumors (e.g., ... Link to item Cite

MRI of papillary meningiomas in children.

Journal Article Pediatr Radiol · November 1995 We report two cases of papillary meningioma in children. The MRI appearance of this special type of meningioma is described for the first time. Both lesions were dura based and associated with cystic components. We review the literature pertaining to this ... Link to item Cite

Epidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII gene.

Journal Article Cell Growth Differ · October 1995 The type III deletion-mutant gene for the epidermal growth factor receptor (EGFRvIII) is frequently expressed in glioblastomas and in breast and non-small cell lung carcinomas. To understand its contribution to the malignant phenotype in humans, we transfe ... Link to item Cite

An archival prospective study of mental health and longevity.

Journal Article Health Psychol · September 1995 The relationship between mental health status and longevity was examined in an archival prospective cohort study (N = 1,103) derived from work begun by Lewis Terman in the 1920s. Degree of psychological maladjustment, cumulatively rated by Terman and his c ... Full text Link to item Cite

Sociodemographic and psychosocial factors in childhood as predictors of adult mortality.

Journal Article Am J Public Health · September 1995 OBJECTIVES: Childhood sociodemographic, psychosocial, and environmental factors are often assumed to affect adult health and longevity. These relationships were prospectively tested by using the 7-decade Terman Life Cycle Study of Children With High Abilit ... Full text Link to item Cite

Intraarterial administration of melphalan for treatment of intracranial human glioma xenografts in athymic rats.

Journal Article Cancer Res · September 1, 1995 Malignant gliomas will affect 15,000-17,000 Americans each year and carry a dismal prognosis. Adjuvant chemotherapy is hampered by inadequate drug delivery, systemic toxicity, and a markedly variable biological sensitivity. Intraarterial (i.a.) therapy may ... Link to item Cite

Cyclophosphamide in combination with sargramostim for treatment of recurrent medulloblastoma.

Journal Article Med Pediatr Oncol · September 1995 Thirteen patients with recurrent medulloblastoma were treated with cyclophosphamide in association with Sargramostim. Cyclophosphamide was given at doses ranging between 1.0-2.5 g/m2 daily for two doses. Sargramostim was given at a fixed dose of 250 microg ... Full text Link to item Cite

Lack of efficacy of postoperative chemotherapy and delayed radiation in very young children with pineoblastoma. Pediatric Oncology Group.

Journal Article Med Pediatr Oncol · July 1995 Eleven infants with pineoblastomas were treated with prolonged postoperative chemotherapy in an attempt to delay radiation and reduce neurotoxicity. These infants were part of the Pediatric Oncology Group infant brain tumor study but the outcome of infants ... Full text Link to item Cite

Hematologic toxicity during craniospinal irradiation: the impact of prior chemotherapy.

Journal Article Med Pediatr Oncol · July 1995 The purpose of this work was to determine the frequency of hematologic toxicity during craniospinal radiation (CSI) and the impact of preirradiation chemotherapy on this frequency. The charts of 37 patients who received CSI were reviewed. Twenty did not ha ... Full text Link to item Cite

Activity of temozolomide in the treatment of central nervous system tumor xenografts.

Journal Article Cancer Res · July 1, 1995 The activity of 8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin- 4(3H)-one (temozolomide) in the treatment of a panel of xenografts derived from ependymoma, medulloblastoma, and childhood and adult high-grade glioma was evaluated in athymic nude mice b ... Link to item Cite

A phase II evaluation of thiotepa followed by other multiagent chemotherapy regimens in infants and young children with malignant brain tumors.

Journal Article Cancer · June 1, 1995 BACKGROUND: Chemotherapy may be used to delay the need for cranial irradiation in infants and young children with malignant central nervous system (CNS) tumors. The polyfunctional alkylator thiotepa (TT) possesses significant in vitro and in vivo activity ... Full text Link to item Cite

Flunarizine enhancement of melphalan activity against drug-sensitive/resistant rhabdomyosarcoma.

Journal Article Br J Cancer · June 1995 Flunarizine, a diphenylpiperazine calcium channel blocker, is known to increase tumor blood flow. It also interferes with calmodulin function, repair of DNA damage and drug resistance associated with P-glycoprotein. Flunarizine was tested for its ability t ... Full text Link to item Cite

Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25.

Other Oncogene · June 1, 1995 The high incidence of loss of chromosome 10 alleles in glioblastoma multiforme suggests the presence on this chromosome of a tumor suppressor gene that is important in glioma tumorigenesis and progression. Our initial deletion mapping studies using restric ... Link to item Cite

A pial window model for the intracranial study of human glioma microvascular function.

Journal Article Neurosurgery · May 1995 A new model for human brain tumor uses the intracranial placement of tumor xenografts under transparent glass cranial windows in nude rats, which require no immunosuppression for tumor engraftment. Adult male nude rats underwent implantation of human anapl ... Full text Link to item Cite

Detection of cerebrospinal fluid metastasis: CT myelography or MR?

Journal Article AJNR Am J Neuroradiol · May 1995 PURPOSE: To determine the sensitivity of contrast MR versus myelography followed by CT in the detection of cerebrospinal fluid metastases in children with primary central nervous system tumors. METHODS: Thirty-three patients who had primary central nervous ... Link to item Cite

SYNCHRONOUS EPENDYMO-GLIOMAS

Conference Journal of Neuropathology and Experimental Neurology · May 1995 Full text Cite

Dose escalation trial of cyclophosphamide with Sargramostim in the treatment of central nervous system (CNS) neoplasms.

Journal Article Med Pediatr Oncol · April 1995 We conducted a dose escalation trial of cyclophosphamide plus Sargramostim in the therapy of patients with newly diagnosed or recurrent central nervous system tumors. Cyclophosphamide was administered at doses ranging between 1.0 and 2.5 g/m2 daily for two ... Full text Link to item Cite

Childhood conscientiousness and longevity: health behaviors and cause of death.

Journal Article J Pers Soc Psychol · April 1995 Previous research showed that conscientiousness (social dependability) in childhood predicted longevity in an archival prospective cohort study of bright children first studied by Terman in the 1920s (H. S. Friedman et al., 1993). Possible behavioral mecha ... Full text Link to item Cite

Intrathecal administration of single-chain immunotoxin, LMB-7 [B3(Fv)-PE38], produces cures of carcinomatous meningitis in a rat model.

Journal Article Proc Natl Acad Sci U S A · March 28, 1995 LMB-7 [B3(Fv)-PE38] is a single-chain immunotoxin constructed from the murine monoclonal antibody B3 and a truncated from of Pseudomonas exotoxin PE38. Antibody B3 recognizes a carbohydrate epitope found on solid tumors that frequently invade the intrathec ... Full text Link to item Cite

Playing with pets and longevity among older people.

Journal Article Psychol Aging · March 1995 Models of the relations between contact with pets and better health are examined in an archival prospective study using data derived from the longitudinal study initiated by Terman in 1921 (current N = 343 men, 300 women). In survival analyses of documente ... Full text Link to item Cite

Vasodilatory state of decompensated cirrhosis: relation to hepatic dysfunction, ascites, and vasoactive substances.

Journal Article Alcohol Clin Exp Res · February 1995 The objective of this study was to determine the relations between the hallmark circulatory finding of decompensated cirrhosis, a reduced systemic vascular resistance (SVR), and the indices of hepatic decompensation, the accumulation of ascites, and the co ... Full text Link to item Cite

Psychosocial and behavioral predictors of longevity. The aging and death of the "termites".

Journal Article Am Psychol · February 1995 Impulsive, undercontrolled personalities and major family stresses are known predictors of impaired adjustment, but long-term health effects are unclear. In an archival prospective cohort design, we followed up on L. M. Terman's (Terman & Oden, 1947) sampl ... Full text Link to item Cite

Meta-[131I]iodobenzylguanidine uptake and meta-[211At]astatobenzylguanidine treatment in human medulloblastoma cell lines.

Journal Article J Neurooncol · 1995 Uptake of radioiodinated meta-iodobenzylguanidine (MIBG) has been demonstrated in the neural crest tumors, including neuroblastoma, pheochromocytoma, and carcinoid tumors, and is presently in use diagnostically and therapeutically in these settings. Cells ... Full text Link to item Cite

Prognostic value of contrast-enhanced magnetic resonance imaging in brainstem gliomas.

Journal Article Pediatr Neurosurg · 1995 Brainstem gliomas are an important oncologic problem in the pediatric age group, constituting between 10 and 15% of childhood central nervous system neoplasms. A new classification scheme based on magnetic resonance imaging (MRI) has recently been proposed ... Full text Link to item Cite

A phase II study of every other day high-dose ifosfamide in pediatric brain tumors: a Pediatric Oncology Group Study.

Journal Article J Neurooncol · 1995 Despite reported activity in many other solid tumors, high-dose ifosfamide produces few objective responses in recurrent pediatric brain tumors. Alkylating agents such as cyclophosphamide (CYCLO) possess good activity in many of solid tumors, including bra ... Full text Link to item Cite

Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors.

Journal Article Cancer Chemother Pharmacol · 1995 The efficacy of protracted schedules of therapy of the topoisomerase I inhibitors 9-dimethyl-aminomethyl-10-hydroxycamptothecin (topotecan) and 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (irinotecan; CPT-11) were evaluated against a ... Full text Link to item Cite

The effect of L-amino acid oxidase on activity of melphalan against an intracranial xenograft.

Journal Article Cancer Chemother Pharmacol · 1995 We have previously shown that diet restriction-induced depletion of large neutral amino acids (LNAAs) in murine plasma to 46% of control significantly enhances intracranial delivery of melphalan without enhancing delivery to other organs. Studies have now ... Full text Link to item Cite

Cyclophosphamide therapy of medulloblastoma: from the laboratory to the clinic and back again (and again and again).

Journal Article J Neurooncol · 1995 Medulloblastoma, the most common malignancy of childhood, was originally shown to be sensitive to cyclophosphamide in 1981. We have used combined laboratory and clinical investigations to demonstrate the synergy of cyclophosphamide and vincristine in the t ... Full text Link to item Cite

Hyperthermic modulation of radiolabelled antibody uptake in a human glioma xenograft and normal tissues.

Journal Article Int J Hyperthermia · 1995 These experiments investigate the biodistribution of radiolabelled MAb in a human glioma xenograft model after 4 h of local hyperthermia (HT) with a twofold purpose: to maximize the ratio of cumulative isotope activity in tumour relative to normal tissues, ... Full text Link to item Cite

Prognostic implications of chromosome 17p deletions in human medulloblastomas.

Journal Article J Neurooncol · 1995 DNA derived from medulloblastoma biopsies was analyzed to determine if deletions of the 17p region, mutations of the TP53 gene, or amplification of the c-myc, N-myc, EGFR (epidermal growth factor receptor), or MDM2 (murine double-minute-2) genes was indica ... Full text Link to item Cite

Phase I studies of treatment of malignant gliomas and neoplastic meningitis with 131I-radiolabeled monoclonal antibodies anti-tenascin 81C6 and anti-chondroitin proteoglycan sulfate Me1-14 F (ab')2--a preliminary report.

Journal Article J Neurooncol · 1995 The advent of monoclonal antibody (MAb) technology has made Ehrlich's postulate of the 'magic bullet' an attainable goal. Although specific localization of polyvalent antibodies to human gliomas was demonstrated in the 1960s, the lack of specific, high aff ... Full text Link to item Cite

Drugs of abuse and immunosuppression

Conference NIDA Research Monograph Series · December 1, 1994 Cite

Metabolism of O6-benzylguanine, an inactivator of O6-alkylguanine-DNA alkyltransferase.

Journal Article Cancer Res · October 1, 1994 O6-Benzylguanine effectively inactivates the DNA repair protein, O6-alkylguanine-DNA alkyltransferase, leading to an increase in the therapeutic index of 1,3-bis(2-chloroethyl)-1-nitrosourea in nude mouse xenograft studies. To investigate the fate of this ... Link to item Cite

Is breast-feeding in infancy associated with adult longevity?

Journal Article Am J Public Health · September 1994 OBJECTIVES: The purpose of the study was to determine whether breast-feeding is associated with increased longevity or cause-specific survival. METHODS: Teachers throughout California identified intellectually gifted children as part of a prospective study ... Full text Link to item Cite

Intrathecal melphalan therapy of human neoplastic meningitis in athymic nude rats.

Journal Article Cancer Res · September 1, 1994 We report the activity and toxicity of intrathecal melphalan in the treatment of human neoplastic meningitis in the subarachnoid space of athymic nude rats. Animals received injections via chronic indwelling subarachnoid catheters with 5 x 10(5) or 5 x 10( ... Link to item Cite

Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme

Journal Article Journal of the National Cancer Institute · July 6, 1994 We would like to correct a mistake in this report. We have recently discovered that the human medulloblastoma line D341 Med was cross-contaminated in our laboratory with the human rhabdomyosarcoma line TE-671. Accordingly, enhancement of nitrosourea activi ... Full text Cite

Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan.

Journal Article Cancer Res · July 1, 1994 Previous investigations have revealed that the human TE-671 MR human rhabdomyosarcoma xenograft selected in vivo for melphalan resistance (M. C. Rosenberg, et al., Cancer Res., 49: 6917-6922, 1989) is cross-resistant to a wide variety of alkylating agents ... Link to item Cite

Re: Toxicity of intrathecal melphalan.

Journal Article J Natl Cancer Inst · June 1, 1994 Full text Link to item Cite

METABOLIC CHARACTERIZATION OF PEDIATRIC PRIMARY BRAIN-TUMORS USING FDG-PET

Journal Article JOURNAL OF NUCLEAR MEDICINE · May 1, 1994 Link to item Cite

Symptoms of patients with silent ischemia as detected by thallium stress testing.

Journal Article Chest · April 1994 This study was undertaken to determine whether patients with silent ischemia (SI) (a positive thallium stress test without chest pain) have nonchest-pain symptoms that might serve as "anginal equivalents." Two hundred ninety-four individuals on completing ... Full text Link to item Cite

Gadolinium enhancement of the leptomeninges caused by hydrocephalus: a potential mimic of leptomeningeal metastasis.

Journal Article AJNR Am J Neuroradiol · April 1994 A patient had severe hydrocephalus and diffuse leptomeningeal enhancement on MR which mimicked leptomeningeal spread of a primary brain tumor. The leptomeningeal enhancement resolved completely after decompression of the hydrocephalus. Data suggest that th ... Link to item Cite

Alterations of the TP53 gene in human gliomas.

Journal Article Cancer Res · March 1, 1994 Glial tumors of all grades and histological types from 72 adults and 48 children were analyzed for mutations of the TP53 gene, loss of heterozygosity (LOH) for 17p, and accumulation of TP53 protein to determine whether the incidence and type of TP53 altera ... Link to item Cite

MR imaging of high-grade cerebral gliomas: value of diffusion-weighted echoplanar pulse sequences.

Journal Article AJR Am J Roentgenol · March 1994 OBJECTIVE: The purpose of this study was to evaluate the usefulness of diffusion-weighted echoplanar MR imaging in the examination of high-grade brain gliomas compared with that of conventional spin-echo (SE) or fast spin-echo (FSE) MR imaging. We hypothes ... Full text Link to item Cite

Do non-scientists really live longer?

Journal Article Lancet · January 29, 1994 Full text Link to item Cite

Cerebral atrophy in an infant following treatment with ifosfamide.

Journal Article Med Pediatr Oncol · 1994 Ifosfamide, a nitrogen mustard derived alkylating agent commonly used in the treatment of solid tumors, has been associated with neurotoxicity in 5-33% of treated patients. Encephalopathy most often occurs during or shortly following drug administration, w ... Full text Link to item Cite

Hyperfractionated irradiation and concurrent cisplatin in brain stem tumors: a Pediatric Oncology Group pilot study (9139).

Journal Article Pediatr Neurosurg · 1994 A phase I Pediatric Oncology Group Study was performed combining 7,020 cGy hyperfractionated irradiation (117 cGy twice daily separated by 6 h) with increasing concurrent doses of cisplatin given with the intent of radiosensitization as treatment for child ... Full text Link to item Cite

Hyperthermic sensitization by the radical initiator 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH). I. In vitro studies.

Journal Article Int J Hyperthermia · 1994 AAPH (2,2'-azobis-(2-amidinopropane dihydrochloride)) is a water-soluble, heat-labile azo compound which undergoes thermal decomposition to produce carbon-centred free radicals. These carbon-centred radicals might be directly cytotoxic or may react with ox ... Full text Link to item Cite

Biodistribution of O6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL.

Journal Article Cancer Chemother Pharmacol · 1994 O6-Benzylguanine effectively inactivates the DNA-repair protein O6-alkylguanine-DNA alkyltransferase in tumor cells and has been shown to increase the cytotoxicity of chloroethylnitrosoureas. This study was undertaken to ascertain the optimal vehicle for f ... Full text Link to item Cite

Management of pineal non-germinoma germ cell tumor with residual teratoma and normal alpha-fetoprotein.

Journal Article Med Pediatr Oncol · 1994 A 16-year-old white male presented with multiple abnormal extraocular movements secondary to an enhancing pineal tumor. Subtotal resection of the lesion revealed a mixed malignant germ cell tumor. The preoperative serum alpha-fetoprotein (AFP) was markedly ... Full text Link to item Cite

Busulfan therapy of central nervous system xenografts in athymic mice.

Journal Article Cancer Chemother Pharmacol · 1994 We evaluated the antitumor activity of busulfan against a panel of tumor cell lines and xenografts in athymic nude mice derived from childhood high-grade glioma, adult high-grade glioma, ependymoma, and medulloblastoma. Busulfan displayed similar activity ... Full text Link to item Cite

Activity of 9-dimethylaminomethyl-10-hydroxycamptothecin against pediatric and adult central nervous system tumor xenografts.

Journal Article Cancer Chemother Pharmacol · 1994 The activity of dimethylaminomethyl-10-hydroxycamptothecin (topotecan) was evaluated against a panel of xenografts derived from ependymomas (D528 EP, D612 EP), childhood high-grade gliomas (D-456 MG, D-212 MG), adult high-grade gliomas (D-245 MG, D-54 MG), ... Full text Link to item Cite

Well differentiated astrocytoma occurring nine years after radiation therapy for medulloblastoma.

Journal Article Clin Neuropathol · 1994 Conventional treatment for medulloblastoma includes surgical resection followed by craniospinal irradiation, with the potential risk of subsequent radiotherapy-induced secondary neoplasms. We report a 23-year-old woman previously irradiated nine years earl ... Link to item Cite

Arteriovenous malformation mimicking recurrent medulloblastoma.

Journal Article Med Pediatr Oncol · 1994 Magnetic resonance imaging (MRI) is becoming the method of choice for evaluation of central nervous system tumors. However, the sensitivity of this modality raises concern that new lesions in patients previously diagnosed with a brain tumor may not necessa ... Full text Link to item Cite

COMPOSITE NEUROBLASTOMA MALIGNANT GLIOMA

Journal Article LABORATORY INVESTIGATION · January 1, 1994 Link to item Cite

Preradiation chemotherapy in advanced medulloblastoma. A Pediatric Oncology Group pilot study.

Journal Article Cancer · November 1, 1993 BACKGROUND: Children diagnosed with medulloblastoma whose tumor involves the brain stem or has spread through the cerebrospinal fluid pathways to other areas of the brain or spinal cord have a poor prognosis despite therapy with surgery, craniospinal irrad ... Full text Link to item Cite

Radioiodination of a monoclonal antibody using N-succinimidyl 5-iodo-3-pyridinecarboxylate.

Journal Article Nucl Med Biol · October 1993 The potential utility of N-succinimidyl 5-iodo-3-pyridinecarboxylate (SIPC) for the radioiodination of monoclonal antibodies was investigated. Paired-label studies were performed using the anti-tenascin antibody 81C6 in athymic mice bearing subcutaneous D- ... Full text Link to item Cite

Surgery, hyperfractionated craniospinal irradiation, and adjuvant chemotherapy in the management of supratentorial embryonal neuroepithelial neoplasms in children.

Journal Article Surg Neurol · October 1993 Supratentorial embryonal neuroepithelial tumors are undifferentiated neoplasms. We have used this term in preference to the controversial classification primitive neuroectodermal tumors (PNET). These lesions in children are malignant neoplasms which are us ... Full text Link to item Cite

Final results of a study of escalating doses of hyperfractionated radiotherapy in brain stem tumors in children: a Pediatric Oncology Group study.

Journal Article Int J Radiat Oncol Biol Phys · September 30, 1993 PURPOSE: In September 1984, the Pediatric Oncology Group began accrual to a Phase I/II study designed to assess the efficacy and toxicity of sequentially escalated doses of hyperfractionated (twice daily) radiotherapy in children with poor-prognosis brain ... Full text Link to item Cite

Treatment of acute myocardial infarction.

Journal Article N Engl J Med · August 5, 1993 Full text Link to item Cite

Efficacy and toxicity of 9-beta-D-arabinofuranosylguanine (araG) as an agent to purge malignant T cells from murine bone marrow: application to an in vivo T-leukemia model.

Journal Article Leukemia · August 1993 9-beta-D-Arabinofuranosylguanine (araG), an analog of deoxyguanosine which is not degraded by purine nucleoside phosphorylase, has been previously shown in in vitro studies by our laboratory to be effective in purging malignant T cells from human bone marr ... Link to item Cite

Carboplatin treatment of progressive optic pathway gliomas to delay radiotherapy.

Journal Article J Neurosurg · August 1993 Six patients with optic pathway gliomas who were previously managed with surgery and/or chemotherapy were treated with carboplatin (560 mg/sq m) after radiographic evidence of disease progression. The median age at diagnosis was 2 years (range 4 months to ... Full text Link to item Cite

Pilocytic astrocytoma: correlation between the initial imaging features and clinical aggressiveness.

Journal Article AJR Am J Roentgenol · August 1993 OBJECTIVE: Astrocytomas are classified as either fibrillary or pilocytic on the basis of their histologic appearance. The imaging features of the fibrillary astrocytoma correlate closely with the tumor's clinical aggressiveness and are, therefore, useful i ... Full text Link to item Cite

Management of leukemic hyperleukocytosis with hydration, urinary alkalinization, and allopurinol. Are cranial irradiation and invasive cytoreduction necessary?

Journal Article Am J Pediatr Hematol Oncol · August 1993 PURPOSE: Hyperleukocytosis secondary to acute leukemia is a medical emergency. Intracranial hemorrhage often leads to death in this setting. Early efforts to prevent this serious complication have included emergent cranial irradiation, with its associated ... Link to item Cite

Cardiac cell toxicity induced by 4-hydroperoxycyclophosphamide is modulated by glutathione.

Journal Article Cardiovasc Res · July 1993 OBJECTIVE: Cardiac myocytes were exposed to 4-hydroperoxycyclophosphamide (4-HC, an activated derivative of cyclophosphamide) to assess whether early ionic events are associated with the dose limiting toxicity of this chemotherapeutic agent. METHODS: Prima ... Full text Link to item Cite

Does childhood personality predict longevity?

Journal Article J Pers Soc Psychol · July 1993 Key models relating personality and health predict that personality in childhood is indicative of later health and longevity. Longevity predictions are tested using data derived from the 7-decade longitudinal study initiated by L. M. Terman 1921 (L. M. Ter ... Full text Link to item Cite

Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors.

Journal Article N Engl J Med · June 17, 1993 BACKGROUND: Among patients with malignant brain tumors, infants and very young children have the worst prognosis and the most severe treatment-related neurotoxic effects. Therefore, in 1986, the Pediatric Oncology Group began a study in which postoperative ... Full text Link to item Cite

Chemotherapy for pilocytic astrocytomas.

Journal Article Cancer · May 15, 1993 BACKGROUND: Although pilocytic astrocytomas (PA) generally are considered benign, a subset of patients with PA have disease progression despite standard treatment with surgery and radiation therapy. The authors report their experience with chemotherapy in ... Full text Link to item Cite

Intraarterial therapy of human glioma xenografts in athymic rats using 4-hydroperoxycyclophosphamide.

Journal Article Cancer Res · May 15, 1993 The addition of chemotherapy, notably using nitrosoureas, in the treatment of patients with glioblastoma multiforme has resulted in only modest improvements in long-term patient survival over the use of surgical intervention and irradiation alone. Intraart ... Link to item Cite

Mesenrhombencephalitis: MR findings in nine patients.

Journal Article AJR Am J Roentgenol · May 1993 OBJECTIVE: Mesenrhombencephalitis is a serious form of brainstem inflammation predominantly involving the deep and vital portions of the brain, that is, the mesencephalon (midbrain) and rhombencephalon (pons, medulla). Mesenrhombencephalitis is difficult t ... Full text Link to item Cite

NEUROPATHOLOGY OF MULTIPLE VERSUS SINGLE DOSE INTRATHECAL MELPHALAN IN RATS

Conference Journal of Neuropathology and Experimental Neurology · May 1993 Full text Cite

EXPRESSION OF C-MYC IN MEDULLOBLASTOMA XENOGRAFTS

Journal Article Journal of Neuropathology and Experimental Neurology · May 1993 Full text Cite

Demonstration of a relation between urinary digoxin-like immunoreactive substance and cardiac performance.

Journal Article Chest · March 1993 OBJECTIVE: To determine the relation between urinary digoxin-like immunoreactive substance (DLIS) and cardiac performance. DESIGN: Cohort study. SETTING: Echocardiography laboratory of a university-affiliated teaching hospital. SUBJECTS: Thirty-four indivi ... Full text Link to item Cite

Postradiation cerebellar necrosis mimicking tumor: MR appearance.

Journal Article J Comput Assist Tomogr · 1993 Cerebellar necrosis associated with therapy of primary gliomas is unusual. We present the MR findings in a patient with postradiation multifocal cerebellar necrosis mimicking tumor dissemination. ... Full text Link to item Cite

Role of glutathione in cellular resistance to alkylating agents.

Journal Article Adv Enzyme Regul · 1993 Both elevated glutathione levels and increased activity of the enzyme glutathione S-transferase have been associated with the resistance of cells to alkylating agents. We have demonstrated that one mechanism of this resistance is the inactivation of the al ... Full text Link to item Cite

Comparison of serial PET and MRI scans in a pediatric patient with a brainstem glioma.

Journal Article Med Pediatr Oncol · 1993 Profound clinical deficits may be associated with insults to the brainstem, making management of patients with brainstem gliomas very complex. Small changes in the radiographic appearance of a brainstem tumor may be associated with significant clinical det ... Full text Link to item Cite

False-positive MRI detection of recurrent or metastatic pediatric infratentorial tumors.

Journal Article Med Pediatr Oncol · 1993 Gadolinium-DTPA enhanced MRI is the modality of choice when imaging central nervous system infratentorial tumors in the pediatric population. The detection of a new enhancing lesion following initiation of therapy is typically considered pathognomonic for ... Full text Link to item Cite

Development of a model of melphalan-induced gastrointestinal toxicity in mice.

Journal Article Cancer Chemother Pharmacol · 1993 The tolerated dose of melphalan is limited by bone marrow suppression; when this complication is ameliorated by bone marrow transplantation, the dose-limiting toxicity becomes gastrointestinal mucositis. No intervention to date has been successful in modul ... Full text Link to item Cite

Lactotetraose series ganglioside 3',6'-isoLD1 in tumors of central nervous and other systems in vitro and in vivo.

Journal Article Cancer Res · January 1, 1993 Two monoclonal antibodies, DMAb-21 and DMAb-22, directed against the lactotetraose series ganglioside-associated epitope IV3NeuAc,III6-NeuAcLcOse4Cer (3',6'-isoLD1), were found to define the minimum binding epitope NeuAc(or NeuGc)alpha 2-3Gal beta 1-3(NeuA ... Link to item Cite

MRI of gangliocytoma of cerebellum and spinal cord.

Other J Comput Assist Tomogr · 1993 Gangliocytomas are rare CNS tumors that occur in children and young adults. We present a case of a cerebellar gangliocytoma with invasion of the cervical spinal cord demonstrated on MR. Radiographic differentiation of gangliocytomas from other ganglion cel ... Full text Link to item Cite

Treatment of subcutaneous and intracranial brain tumor xenografts with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.

Journal Article Cancer Chemother Pharmacol · 1993 O6-Alkylguanine-DNA alkyltransferase (AT) is a cellular protein that protects cells from the cytotoxic effects of nitrosoureas by repairing alkyl lesions at the O6 position of guanine. We have studied the ability of O6-benzylguanine to deplete AT activity ... Full text Link to item Cite

Intraarterial Therapy of Human Glioma Xenografts in Athymic Rats Using 4-Hydroperoxycyclophosphamide

Journal Article Cancer Research · January 1, 1993 The addition of chemotherapy, notably using nitrosoureas, in the treatment of patients with glioblastoma multiforme has resulted in only modest improvements in long-term patient survival over the use of surgical intervention and irradiation alone. Intraart ... Cite

Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.

Journal Article J Natl Cancer Inst · December 16, 1992 BACKGROUND: Although chemotherapy offers promise of increased survival for children with medulloblastoma and glioblastoma multiforme, drug resistance occurs frequently, resulting in tumor progression and death. Resistance to nitrosoureas and methylating ag ... Full text Link to item Cite

Disease-prone and self-healing personalities.

Journal Article Hosp Community Psychiatry · December 1992 Full text Link to item Cite

The effect of an amino acid-lowering diet on the rate of melphalan entry into brain and xenotransplanted glioma.

Journal Article Cancer Res · October 15, 1992 Melphalan (L-phenylalanine mustard, L-PAM, alkeran; molecular weight, 305,000) is transported across tumor cell membranes and the blood-brain barrier by the large neutral amino acid (LNAA) transport system. Normally, plasma LNAA levels are high enough and ... Link to item Cite

Shigellosis-associated encephalopathy.

Journal Article Pediatr Infect Dis J · October 1992 Full text Link to item Cite

Ascites as a marker for the hyperdynamic heart of Laennec's cirrhosis.

Journal Article Alcohol Clin Exp Res · October 1992 UNLABELLED: The purpose of this study was to determine the relation of the circulatory findings of cirrhosis to hepatic decompensation. Twenty individuals with biopsy-proven cirrhosis and 15 aged-matched controls underwent echocardiographic evaluation of c ... Full text Link to item Cite

Cyclophosphamide resistance in medulloblastoma.

Journal Article Cancer Res · October 1, 1992 Mechanisms of tumor resistance to 4-hydroperoxycyclophosphamide (4-HC) were studied by using a panel of human medulloblastoma cell lines either passaged in the laboratory for resistance to 4-HC or established from tumors showing clinical resistance to cycl ... Link to item Cite

Successful therapy for trilateral retinoblastoma.

Journal Article Am J Ophthalmol · July 15, 1992 Trilateral retinoblastoma, the intracranial malignancy associated with bilateral retinoblastoma, is an uncommon and clinically aggressive malignancy with a uniformly fatal outcome. Three children with newly diagnosed trilateral retinoblastoma were treated ... Full text Link to item Cite

New therapeutic options in the management of childhood brain tumors.

Journal Article Oncology (Williston Park) · May 1992 With only about 1,500 new cases a year of pediatric brain tumors, as many cases as possible must be enrolled in ongoing multicenter trials if therapeutic advances are to continue. To date, such trials have identified chemotherapeutic agents active against ... Link to item Cite

Expression of O6-methylguanine-DNA methyltransferase in six human medulloblastoma cell lines.

Journal Article Cancer Res · March 1, 1992 Six well characterized human medulloblastoma cell lines (D283 Med, Daoy, D341 Med, D384 Med, D425 Med, and D458 Med) were examined for the expression of O6-methylguanine-DNA methyltransferase (MGMT) by activity and Western and Northern blot analysis. High ... Link to item Cite

Treatment of children with progressive or recurrent brain tumors with carboplatin or iproplatin: a Pediatric Oncology Group randomized phase II study.

Journal Article J Clin Oncol · February 1992 PURPOSE: The Pediatric Oncology Group (POG) conducted a randomized phase II study to evaluate the activity of carboplatin and iproplatin in children with progressive or recurrent brain tumors. PATIENTS AND METHODS: The study was designed to evaluate the ac ... Full text Link to item Cite

Hyperthermia-induced enhancement of melphalan activity against a melphalan-resistant human rhabdomyosarcoma xenograft.

Journal Article Radiat Res · February 1992 The effects of regional hyperthermia (42 degrees C for 70 min) on the antitumor activity of melphalan were examined in athymic mice bearing melphalan-resistant human rhabdomyosarcoma (TE-671 MR) xenografts growing in the right hind limb, and results were c ... Link to item Cite

Reversal of radiation-induced neutropenia by granulocyte colony-stimulating factor.

Journal Article Med Pediatr Oncol · 1992 Myelosuppression is a common sequelae of radiotherapy, occasionally delaying the completion of treatment. In this report, we describe successful reversal of radiation-induced neutropenia in a child receiving craniospinal irradiation by granulocyte colony-s ... Full text Link to item Cite

Phase III clinical evaluation of gadoteridol injection: experience in pediatric neuro-oncologic MR imaging.

Journal Article Pediatr Radiol · 1992 Twenty-two pediatric patients with known CNS neoplasms underwent magnetic resonance (MR) imaging before and after intravenous injection of 0.1 mmol/kg gadoteridol injection as part of a Phase IIIB open label multicenter clinical trial. Intravenous administ ... Full text Link to item Cite

FDG-PET in pediatric posterior fossa brain tumors.

Journal Article J Comput Assist Tomogr · 1992 Seventeen pediatric patients with posterior fossa brain tumors were studied with 2-[18F]fluoro-2-deoxy-D-glucose (FDG) and positron emission tomography (PET). The FDG uptake was ranked by two observers, and the results were correlated with tumor histology. ... Full text Link to item Cite

Subfrontal recurrence of medulloblastoma.

Journal Article AJNR Am J Neuroradiol · 1992 Link to item Cite

The radiation dose-response relationship in a human glioma xenograft and an evaluation of the influence of glutathione depletion by buthionine sulfoximine.

Journal Article Int J Radiat Oncol Biol Phys · 1992 We have used an extensively characterized human glioma cell line in an athymic mouse model to evaluate new therapeutic approaches for human supratentorial high grade gliomas. The tumor, D-54MG, is a subline of a human anaplastic glioma. Eight days after ho ... Full text Link to item Cite

Phase I study of BCNU and intravenous 6-mercaptopurine in patients with anaplastic gliomas.

Journal Article Cancer Chemother Pharmacol · 1992 On the basis of response rates of up to 50%, BCNU [1,3-bis(2-chloroethyl)-1-nitrosourea] is the primary drug used in the chemotherapy of anaplastic gliomas. Preclinical data obtained in several experimental systems show that the cytotoxicity of chloroethyl ... Full text Link to item Cite

Effects of glutathione or polyamine depletion on in vivo thermosensitization.

Journal Article Int J Hyperthermia · 1992 Investigations with the melphalan-sensitive and -resistant human rhabdomyosarcoma xenografts TE-671 and TE-671 MR were performed to examine the effect of glutathione and polyamine modulation on thermosensitivity. Regimens of intraperitoneally injected and ... Full text Link to item Cite

Enhancement of melphalan-induced gastrointestinal toxicity in mice treated with regional hyperthermia and BSO-mediated glutathione depletion.

Journal Article Int J Hyperthermia · 1992 Both hyperthermia and glutathione depletion have been shown to increase the antineoplastic activity of melphalan. Investigations were carried out to define the toxicity and activity of melphalan given in conjunction with local (right hind limb) hyperthermi ... Full text Link to item Cite

The radiation dose-response relationship in a human glioma xenograft and an evaluation of the influence of glutathione depletion by buthionine sulfoximine

Journal Article International Journal of Radiation Oncology, Biology, Physics · 1992 We have used an extensively characterized human glioma cell line in an athymic mouse model to evaluate new therapeutic approaches for human supratentorial high grade gliomas. The tumor, D-54MG, is a subline of a human anaplastic glioma. Eight days after ho ... Cite

Nonverbal display of emotion in public and in private: self-monitoring, personality, and expressive cues.

Journal Article J Pers Soc Psychol · November 1991 Individual differences in the expression and regulation of emotion are important components of social skill. The present study focused on the concealing of spontaneous expressions of happiness after winning in a competitive situation against peers. In a re ... Full text Link to item Cite

Inflammatory lesion mimicking a metastatic ependymoma.

Journal Article Neurosurgery · October 1991 A 2.5-year-old child who had undergone nearly total resection of an infratentorial ependymoma demonstrated a new enhancing lesion on the undersurface of the right cerebellar hemisphere 7 weeks after the initiation of adjuvant chemotherapy. The residual pri ... Full text Link to item Cite

Infrequent p53 gene mutations in medulloblastomas.

Journal Article Cancer Res · September 1, 1991 Cytogenetic and molecular studies of medulloblastomas have demonstrated frequent loss of sequences from the short arm of chromosome 17, possibly implicating loss or inactivation of the p53 tumor suppressor gene. We amplified exons 5 through 8 of the p53 ge ... Link to item Cite

Deletion-mutant epidermal growth factor receptor in human gliomas: effects of type II mutation on receptor function.

Journal Article Biochem Biophys Res Commun · August 15, 1991 Malignant human glioma D-298 MG amplifies a rearranged epidermal growth factor receptor (EGFR) gene (c-erbB proto-oncogene), resulting in an in-frame deletion of 83 amino acids in domain IV of the extracellular domain of the EGFR. EGF and transforming grow ... Full text Link to item Cite

Medulloblastoma: tumor biological and clinical perspectives.

Journal Article J Neurooncol · August 1991 Medulloblastoma is the most common central nervous system malignancy of childhood, with approximately 350 new cases seen in the United States each year. Although the low incidence of this tumor, compared with adult neoplasms such as breast or colon carcino ... Full text Link to item Cite

Therapeutic analysis of melphalan-resistant human rhabdomyosarcoma xenograft TE-671 MR.

Journal Article Cancer Res · August 1, 1991 Investigations with the melphalan-resistant human rhabdomyosarcoma xenograft TE-671 MR were carried out to identify patterns of cross-resistance and collateral sensitivity and to define the mechanism(s) mediating melphalan resistance. TE-671 MR was cross-r ... Link to item Cite

Leptomeningeal dissemination of optic pathway gliomas in three children.

Journal Article Am J Ophthalmol · June 15, 1991 We treated three children with optic pathway gliomas who had progressive disease associated with metastatic spread to the leptomeninges. One patient had radiographic resolution of leptomeningeal disease after treatment with intravenous carmustine and oral ... Full text Link to item Cite

The arrhythmogenicity of theophylline. A multivariate analysis of clinical determinants.

Journal Article Chest · June 1991 OBJECTIVE: to determine the relation of serum theophylline concentrations (STC) to the occurrence of cardiac arrhythmias in a population of hospitalized patients. STUDY DESIGN: A cross-sectional study of 100 patients receiving theophylline who had electroc ... Full text Link to item Cite

Differentiation characteristics of newly established medulloblastoma cell lines (D384 Med, D425 Med, and D458 Med) and their transplantable xenografts.

Journal Article Lab Invest · June 1991 Three new human medulloblastoma (MB) cell lines (D384 Med, D425 Med, and D458 Med) and their transplantable xenografts were examined for antigenic expression with antibodies against neuroectodermal antigens, cytoskeletal proteins, neuroendocrine markers, g ... Link to item Cite

Therapeutic analysis of in vitro and in vivo brain tumor models.

Journal Article Neurol Clin · May 1991 Virtually all brain tumor models studied to date have demonstrated the activity of the nitrosoureas, an observation confirmed in a cohort of adult patients with high-grade gliomas. However, studies with animal brain tumor models have not led to the selecti ... Link to item Cite

Theophylline produces an adverse effect on myocardial lactate metabolism at a therapeutic serum concentration: an effect blocked by verapamil.

Journal Article J Pharmacol Exp Ther · April 1991 To assess the actions of theophylline on coronary blood flow and myocardial energetics, 1 mg/kg/min of this methylxanthine was infused i.v. in the dog for 15 min, producing an average concentration of 18 +/- 3 micrograms/ml. Heart rate increased by 20 +/- ... Link to item Cite

Tumors of the central nervous system. Improvement in outcome through a multimodality approach.

Journal Article Pediatr Clin North Am · April 1991 More children with CNS tumors will continue to be cured of their neoplasms as a result of improved surgical, radiotherapeutic, and chemotherapeutic intervention. The complex problems seen in these patients mandate their treatment at academic centers active ... Full text Link to item Cite

Medical appropriateness of coronary angiograms.

Journal Article N Engl J Med · March 7, 1991 Full text Link to item Cite

Glycolipids and glycosyltransferases in permanent cell lines established from human medulloblastomas.

Journal Article Biochim Biophys Acta · February 5, 1991 Medulloblastoma biopsies are heterogenous and might contain normal brain tissue, which limits the usefulness of such tumor material for biochemical analyses. We have, therefore, examined the gangliosides and their metabolism using the medulloblastoma cell ... Full text Link to item Cite

Vincristine therapy for severe platelet alloimmunization.

Journal Article Am J Pediatr Hematol Oncol · 1991 A 19-month-old girl with idiopathic severe aplastic anemia refractory to multi-agent immunosuppressive therapy developed severe platelet alloimmunization following several months of platelet transfusions. She became refractory to human leukocyte antigen (H ... Full text Link to item Cite

Reversible neurotoxicity following hyperfractionated radiation therapy of brain stem glioma.

Journal Article Med Pediatr Oncol · 1991 Two patients with brain stem gliomas were treated with hyperfractionated radiation therapy (HFR) (7,020 and 7,560 cGy, respectively). Despite initial clinical improvement during irradiation, both patients demonstrated clinical deterioration approximately 3 ... Full text Link to item Cite

Osteoblastic metastases from astrocytomas: a report of two cases.

Journal Article Med Pediatr Oncol · 1991 The spread of primary central nervous system (CNS) neoplasms beyond the confines of the neuraxis is a relatively uncommon observation. Extraneural metastases involving bone are quite rare, and have been observed almost exclusively in cases of medulloblasto ... Full text Link to item Cite

Melphalan-induced toxicity in nude mice following pretreatment with buthionine sulfoximine.

Journal Article Cancer Chemother Pharmacol · 1991 Melphalan-induced toxicity in nude mice following pretreatment with a regimen of L-buthionine sulfoximine (BSO), previously shown to enhance the activity of this alkylating agent against rhabdomyosarcoma and glioma xenografts, was examined. Mice were pretr ... Full text Link to item Cite

Positive therapeutic interaction between thiopurines and alkylating drugs in human glioma xenografts.

Journal Article Cancer Chemother Pharmacol · 1991 We used human anaplastic glioma xenografts to evaluate the therapeutic efficacy of combinations of alkylating drugs, either 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), 1-(2-chloroethyl)-3-(2,5-dioxo-3-piperidyl)-1-nitrosourea (PCNU), or procarbazine, and ... Full text Link to item Cite

Medulloblastoma cell-substrate interaction in vitro.

Journal Article Invasion Metastasis · 1991 Medulloblastoma, a highly malignant pediatric tumor of the posterior fossa, demonstrates a marked propensity for leptomeningeal dissemination. Although the predominant site of relapse is the posterior fossa, the prevention of subarachnoid spread would be o ... Link to item Cite

Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts.

Journal Article Cancer Res · December 15, 1990 Both permanent cultured cell lines and athymic mouse xenografts were established from two human glioblastomas. Biopsies from D-245 MG and D-270 MG contained amplified and rearranged epidermal growth factor receptor (EGFR) genes. Although the gene amplifica ... Link to item Cite

Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma.

Journal Article Proc Natl Acad Sci U S A · June 1990 We have investigated human gliomas that amplify and rearrange the epidermal growth factor receptor gene, with generation of an in-frame deletion mutation of 802 nucleotides in the external domain. This in-frame deletion mutation generates a local amino aci ... Full text Link to item Cite

Oncogene amplification in pediatric brain tumors.

Journal Article Cancer Res · May 15, 1990 Despite a considerable amount of information concerning chromosomal and molecular abnormalities found in gliomas in adults, relatively little is known regarding these abnormalities in pediatric brain tumors. We have analyzed DNA from 37 primary brain tumor ... Link to item Cite

Successful laboratory growth and analysis of CUSA-obtained medulloblastoma samples. Technical note.

Journal Article J Neurosurg · May 1990 The development of the Cavitron ultrasonic surgical aspirator (CUSA) has facilitated neurosurgical intervention for removal of central or peripheral nervous system tumors adjacent to or within vital structures. However, laboratory studies defining the phen ... Full text Link to item Cite

NEURON-ASSOCIATED MICROTUBULE PROTEINS IN THE U-251 MALIGNANT GLIOMA CELL LINE

Journal Article Journal of Neuropathology and Experimental Neurology · May 1990 Full text Cite

Glutathione protects cardiac and skeletal muscle from cyclophosphamide-induced toxicity.

Journal Article Cancer Res · April 15, 1990 Administration of cyclophosphamide at a dose which is lethal to 10% of control athymic nude mice resulted in sudden death within 3 h in all mice that had been pretreated with the glutathione synthesis inhibitor L-buthionine-SR-sulfoximine. In Fischer 344 r ... Link to item Cite

Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts.

Journal Article Cancer Res · April 15, 1990 Cultured cell lines and xenografts derived from 7 human medulloblastomas were evaluated for amplification of the c-myc, N-myc, epidermal growth factor receptor, and gli genes by Southern blot analysis. Karyotypes of the original biopsies and early passaged ... Link to item Cite

Treatment of patients with recurrent gliomas with cyclophosphamide and vincristine.

Journal Article J Neurosurg · April 1990 Seventeen patients with recurrent gliomas were treated with the combination of cyclophosphamide and vincristine. All but one had previously received and failed chemotherapy. Cyclophosphamide was administered at doses ranging from 250 to 1000 mg/sq m by int ... Full text Link to item Cite

Enhanced delivery of a monoclonal antibody F(ab')2 fragment to subcutaneous human glioma xenografts using local hyperthermia.

Journal Article Cancer Res · March 15, 1990 The purpose of this study was to investigate the effects of tumor-localized hyperthermia at 42 degrees C on the tissue distribution of radioiodinated monoclonal antibody F(ab')2 fragments. Paired-label biodistribution measurements were performed in athymic ... Link to item Cite

Radioimmunotherapy of intracerebral human glioma xenografts with 131I-labeled F(ab')2 fragments of monoclonal antibody Mel-14.

Journal Article Cancer Res · March 15, 1990 The administration of radiolabeled monoclonal antibodies to improve the treatment of malignant gliomas is dependent upon achieving effective tumor radiation dose while sparing normal tissues. We have evaluated the efficacy of 131I-labeled F(ab')2 fragment ... Link to item Cite

Activity of intrathecal 4-hydroperoxycyclophosphamide in a nude rat model of human neoplastic meningitis.

Journal Article Cancer Res · March 15, 1990 Neoplastic meningitis can result from leptomeningeal dissemination of a variety of cancers. We now report the development of animal models of human neoplastic meningitis and activity of intrathecal 4-hydroperoxycyclophosphamide (4-HC) against the human rha ... Link to item Cite

Rate of buthionine sulfoximine entry into brain and xenotransplanted human gliomas.

Journal Article Cancer Res · February 15, 1990 Buthionine sulfoximine (BSO) is an inhibitor of glutathione synthesis and can be used to potentiate the effects of chemotherapeutic alkylating agents and radiotherapy. We examined the rates of influx and efflux of [35S]BSO administered to athymic mice with ... Link to item Cite

L-buthionine-sulfoximine-mediated radiosensitization in experimental interstitial radiotherapy of intracerebral D-54 MG glioma xenografts in athymic mice.

Journal Article Neurosurgery · February 1990 An intracranial (i.c.) interstitial radiotherapy model in athymic nude mice bearing i.c. D-54 MG human glioma xenografts was developed, allowing evaluation of the therapeutic benefits seen after L-buthionine-S,R-sulfoximine (L-BSO)-mediated depletion of tu ... Full text Link to item Cite

Kinetics and glial fibrillary acidic (GFA) protein production in a transplantable human giant cell glioblastoma (D-212 MG) of near haploid karyotype maintained in an organ culture system. An immunohistochemistry study.

Journal Article Neuropathol Appl Neurobiol · February 1990 A transplantable subcutaneous tumour (designated D-212 MG), sequentially passaged in athymic nude mice and originally derived from a human giant cell glioblastoma, was maintained in an organ culture (matrix) system and studied immunohistochemically after i ... Full text Link to item Cite

Synergistic interactions between cyclophosphamide or melphalan and VP-16 in a human rhabdomyosarcoma xenograft.

Journal Article Cancer Res · January 15, 1990 Based on previous work demonstrating the activity of cyclophosphamide and melphalan in a series of human medulloblastoma and rhabdomyosarcoma cell lines and transplantable xenografts, investigations were conducted to define the effects of combining cycloph ... Link to item Cite

Effects of beta-carotene repletion on beta-carotene absorption, lipid peroxidation, and neutrophil superoxide formation in young men.

Journal Article Nutr Cancer · 1990 The chemopreventive effects of beta-carotene are usually attributed to its antioxidant properties. To determine the effects of beta-carotene supplementation on different parameters of oxidative metabolism, 15 normal young male subjects (18-30 yrs) were pla ... Full text Link to item Cite

Human umbilical cord blood: a clinically useful source of transplantable hematopoietic stem/progenitor cells.

Journal Article Int J Cell Cloning · January 1990 This is a review and discussion of studies leading to the first use of human umbilical cord blood, material usually discarded, for the provision of stem/progenitor cells for clinical hematopoietic reconstitution. This prospect arose as a result of extensiv ... Full text Link to item Cite

Gd-DTPA-enhanced MR imaging of leptomeningeal spread of primary intracranial CNS tumor in children.

Journal Article AJNR Am J Neuroradiol · 1990 Three children with known primary brain neoplasms and leptomeningeal disease were evaluated with MR imaging. Two of the patients had medulloblastoma and one had pineoblastoma. The presence of leptomeningeal tumor spread was established by positive CSF cyto ... Link to item Cite

Papillary adenocarcinoma of the renal pelvis in a child: case report and brief review of the literature.

Journal Article Med Pediatr Oncol · 1990 Tumors of the renal pelvis are not common in adults and are extremely rare in children. Forty-eight cases of adenocarcinoma of the renal pelvis have been reported, with only one patient under 32 years of age. We report the youngest patient (an 11 year old ... Full text Link to item Cite

Establishment of a melphalan-resistant rhabdomyosarcoma xenograft with cross-resistance to vincristine and enhanced sensitivity following buthionine sulfoximine-mediated glutathione depletion.

Journal Article Cancer Res · December 15, 1989 A melphalan-resistant human rhabdomyosarcoma xenograft, TE-671 MR, was established in athymic mice by serial melphalan treatment of the parent xenograft, TE-671, at the 10% lethal dosage (LD10); significant resistance was evident after ten passages of the ... Link to item Cite

Establishment of a Melphalan-Resistant Rhabdomyosarcoma Xenograft with Cross-Resistance to Vincristine and Enhanced Sensitivity Following Buthionine Sulfoximine-Mediated Glutathione Depletion

Journal Article Cancer Research · December 15, 1989 A melphalan-resistant human rhabdomyosarcoma xenograft, TE-671 MR, was established in athymic mice by serial melphalan treatment of the parent xenograft, TE-671, at the 10% lethal dosage (LD10); significant resistance was evident after ten passages of the ... Cite

Relationship of the demonstration of intermediate filament protein to kinetics of three human neuroepithelial tumor cell lines. Lack of neural-related proteins in most cells in S phase: a double-labeled immunohistochemical study on matrix cultures.

Journal Article Lab Invest · September 1989 The immunocytochemical demonstration of intermediate filament proteins in three human neuroepithelial tumor cell lines maintained in vitro on a three-dimensional matrix was correlated with the proportion of cells in S phase. The cell lines of a medulloblas ... Link to item Cite

Labeling monoclonal antibodies and F(ab')2 fragments with the alpha-particle-emitting nuclide astatine-211: preservation of immunoreactivity and in vivo localizing capacity.

Journal Article Proc Natl Acad Sci U S A · September 1989 alpha-Particles such as those emitted by 211At may be advantageous for radioimmunotherapy since they are radiation of high linear energy transfer, depositing high energy over a short distance. Here we describe a strategy for labeling monoclonal antibodies ... Full text Link to item Cite

Phase II treatment of medulloblastoma and pineoblastoma with melphalan: clinical therapy based on experimental models of human medulloblastoma.

Journal Article J Clin Oncol · July 1989 We conducted a phase II study of intravenous (IV) melphalan in the treatment of children with recurrent medulloblastoma and in the initial treatment of children with poor-prognosis medulloblastoma and pineoblastoma. There was one complete response (CR) and ... Full text Link to item Cite

Chromosomal composition of malignant human gliomas through serial subcutaneous transplantation in athymic mice.

Journal Article Cancer Genet Cytogenet · July 1, 1989 The karyotypes of seven human glioblastomas were followed through serial subcutaneous passage in athymic mice. One tumor maintained the same hypodiploid stemline as seen in the original biopsy. Three tumors that originally had near-diploid stemlines showed ... Full text Link to item Cite

Pulmonary septic emboli mimicking metastatic rhabdomyosarcoma.

Journal Article J Pediatr Surg · May 1989 Central venous catheters have proven to be an important aid for the care of pediatric patients with malignancies receiving chemotherapy. A rare complication of such catheters is pulmonary septic emboli. This report describes a 15-year-old white girl with r ... Full text Link to item Cite

A NUDE RAT MODEL OF LEPTOMENINGEAL TUMOR DISSEMINATION (LTD) OF HUMAN MEDULLOBLASTOMA

Conference Journal of Neuropathology and Experimental Neurology · May 1989 Full text Cite

Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion.

Journal Article J Natl Cancer Inst · April 5, 1989 In previous studies we demonstrated that administration of buthionine sulfoximine (BSO) to athymic BALB/c mice bearing intracranial human glioma xenografts resulted in highly selective depletion of glutathione in neoplastic tissue with minimal effects on c ... Full text Link to item Cite

Coronary care in New York City hospitals.

Journal Article N Y State J Med · April 1989 New York City, with six medical schools and an elaborate emergency medical system, would appear to be a locale with optimal resources for coronary care. To assess coronary care facilities and practices, a comprehensive questionnaire was prepared by a multi ... Link to item Cite

O6-alkylguanine-DNA alkyltransferase and sensitivity to procarbazine in human brain-tumor xenografts.

Journal Article J Neurosurg · April 1989 The level of O6-alkylguanine-deoxyribonucleic acid (DNA) alkyltransferase (AT) was determined in 15 human brain-tumor xenografts in athymic mice. This enzyme is a primary intracellular repair mechanism for lesions produced at the O6 position of guanine by ... Full text Link to item Cite

Criteria for termination of phase II chemotherapy for patients with progressive or recurrent brain tumor.

Journal Article Neurology · January 1989 We report six patients with progressive primary tumors of the brain who had prolonged periods with stable contrast-enhancing CT lesions following initial responses to chemotherapy. Chemotherapy was discontinued after 21 to 36 months, despite the persistenc ... Full text Link to item Cite

Selection of a management strategy for pediatric brainstem tumors.

Journal Article Med Pediatr Oncol · 1989 Brainstem tumors arise in portions of the rhombencephalon and mesencephalon. Some authorities include diencephalic tumors in this group. We have reviewed our clinical experience of 69 children (less than 21 years of age) with brainstem tumors evaluated and ... Full text Link to item Cite

Sudden death and pacemakers.

Journal Article Chest · January 1989 Full text Link to item Cite

Phenotypic analysis of four human medulloblastoma cell lines and transplantable xenografts.

Journal Article J Neuropathol Exp Neurol · January 1989 An extensive panel of monoclonal antibodies (MAb) and monospecific antisera reactive against neuroectodermal-, neuronal-, glial-, and lymphoid-associated antigens, extracellular matrix, HLA, and cell-surface receptors was used to characterize the phenotype ... Full text Link to item Cite

Ganglioside mapping of a human medulloblastoma xenograft.

Journal Article Acta Neuropathol · 1989 The ganglioside patterns of medulloblastomas have never been established; in this study we report the ganglioside profile of the human medulloblastoma cell line TE-671 grown as a xenograft in nude mice. Gangliosides were isolated and structurally analyzed ... Full text Link to item Cite

O6-Alkylguanine-DNA alkyltransferase and sensitivity to procarbazine in human brain-tumor xenografts

Journal Article Journal of Neurosurgery · 1989 The level of O6-alkylguanine-deoxyribonucleic acid (DNA) alkyltransferase (AT) was determined in 15 human brain-tumor xenografts in athymic mice. This enzyme is a primary intracellular repair mechanism for lesions produced at the O6 position of guanine by ... Cite

Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenografts.

Journal Article Biochem Pharmacol · November 15, 1988 D-54 MG, a human glioma-derived continuous cell line growing as subcutaneous or intracranial xenografts in athymic mice, was found to be sensitive to the effects of D,L-buthionine-(SR)-sulfoximine, a selective inhibitor of gamma-glutamylcysteine synthetase ... Full text Link to item Cite

Validity of the type A construct: a reprise.

Journal Article Psychol Bull · November 1988 Full text Link to item Cite

Effects of acetyl strophanthidin on duration of atrial fibrillation in the neurally-intact and blockaded dog.

Journal Article Cardiovasc Drugs Ther · November 1988 Although the inotropic and dromotropic effects of cardiac glycosides in atrial fibrillation (AF) are well recognized, their action on AF itself is not clear. Accordingly, to determine whether cardiac glycosides prolong AF, the duration of electrically indu ... Full text Link to item Cite

Digoxin-like immunoreactivity.

Journal Article Chest · November 1988 Link to item Cite

Comparative localization of murine monoclonal antibody Me1-14 F(ab')2 fragment and whole IgG2a in human glioma xenografts.

Journal Article Cancer Res · October 15, 1988 Monoclonal antibodies (MAbs) targeted to glioma-associated antigens may allow the selective delivery of imaging and therapeutic agents to brain tumors; the use of MAb fragments may be a strategy to further improve tumor uptake of such agents relative to no ... Link to item Cite

Melphalan transport, glutathione levels, and glutathione-S-transferase activity in human medulloblastoma.

Journal Article Cancer Res · October 1, 1988 Melphalan transport, glutathione levels, and glutathione-S-transferase activity were measured in two continuous human medulloblastoma cell lines and transplantable xenografts in athymic nude mice, TE-671 and Daoy. In vitro mean glutathione levels were 10.0 ... Link to item Cite

Transient late magnetic resonance imaging changes suggesting progression of brain stem glioma: implications for entry criteria for phase II trials.

Journal Article Neurosurgery · August 1988 An 8-year-old boy was treated with irradiation (66 Gy) for a brain stem glioma. Five months after the completion of radiotherapy, magnetic resonance imaging demonstrated apparent tumor progression despite the patient's neurological improvement. The child c ... Full text Link to item Cite

Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents.

Journal Article Cancer Res · August 1, 1988 A series of bifunctional alkylators were tested against the genotypically and phenotypically heterogeneous continuous human medulloblastoma cell lines, TE-671, Daoy, and D283 Med in vitro and against TE-671 and Daoy growing as s.c. and intracranial xenogra ... Link to item Cite

Treatment of intracranial human glioma xenografts with 131I-labeled anti-tenascin monoclonal antibody 81C6.

Journal Article Cancer Res · May 15, 1988 Lack of tumor specificity renders current modalities for treating malignant glioma ineffective. The administration of 131I-labeled monoclonal antibody (Mab) 81C6, which reacts with the glioma-associated extracellular matrix antigen, tenascin, to nude mice ... Link to item Cite

Enhanced melphalan cytotoxicity following buthionine sulfoximine-mediated glutathione depletion in a human medulloblastoma xenograft in athymic mice.

Journal Article Cancer Res · May 15, 1988 The effect and therapeutic consequences of buthionine-(SR)-sulfoximine (BSO)-mediated depletion of glutathione in the human medulloblastoma-derived cell line, TE-671, growing as s.c. xenografts in athymic nude mice were examined. The glutathione content of ... Link to item Cite

ANTIGENIC PHENOTYPES OF 4 HUMAN MEDULLOBLASTOMA CELL-LINES AND XENOGRAFTS

Journal Article JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY · May 1, 1988 Link to item Cite

Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts.

Journal Article Cancer Res · April 15, 1988 Xenografts from eight malignant human gliomas were established in athymic mice and were used to study amplification and expression of the epidermal growth factor receptor (EGFR) gene. Tissue identity between biopsy and xenografts was confirmed by karyotypi ... Link to item Cite

Phenotypic and genotypic analysis of a human medulloblastoma cell line and transplantable xenograft (D341 Med) demonstrating amplification of c-myc.

Journal Article Am J Pathol · March 1988 D341 Med is a new continuous cell line and transplantable xenograft derived from a cerebellar medulloblastoma. This line grew in vitro in suspension culture with spontaneous macroscopic spheroid formation and demonstrated 20-fold amplification of c-myc. Cu ... Link to item Cite

LOSS OF EPIDERMAL GROWTH-FACTOR RECEPTOR GENE AMPLIFICATION AS MALIGNANT HUMAN GLIOMAS ESTABLISH IN CULTURE

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · March 1, 1988 Link to item Cite

Rational for "eight-in-one" chemotherapy.

Journal Article J Clin Oncol · February 1988 Full text Link to item Cite

Therapeutic efficacy of antiglioma mesenchymal extracellular matrix 131I-radiolabeled murine monoclonal antibody in a human glioma xenograft model.

Journal Article Cancer Res · February 1, 1988 The development of Mabs, particularly those reactive with primary brain tumors but not with normal brain, provides a potential means of delivering therapeutic agents selectively to human malignant gliomas. Mab 81C6, an IgG2b immunoglobulin, which defines a ... Link to item Cite

Therapeutic Efficacy of Antiglioma Mesenchymal Extracellular Matrix 131I-Radiolabeled Murine Monoclonal Antibody in a Human Glioma Xenograft Model

Journal Article Cancer Research · January 1, 1988 The development of Mabs, particularly those reactive with primary brain tumors but not with normal brain, provides a potential means of delivering therapeutic agents selectively to human malignant gliomas. Mab 81C6 an IgG2b immunoglobulin, which defines an ... Cite

Childhood hepatic mesenchymoma: successful treatment with surgery and multiple-agent chemotherapy.

Journal Article Med Pediatr Oncol · 1988 Malignant undifferentiated sarcoma (mesenchymoma) of the liver is a rare tumor of childhood, with fewer than 100 cases reported in the literature. The overall prognosis for patients with this malignancy is poor. In this report, two children with hepatic me ... Full text Link to item Cite

Hematologic changes occurring with cardiac catheterization.

Journal Article Cathet Cardiovasc Diagn · 1988 The composition of the blood influences rheology and therefore might affect hemodynamics. During cardiac catheterization and angiography, blood is sampled and contrast media, fluid, and heparin are administered. To determine the effects of these perturbati ... Full text Link to item Cite

The localisation of radiolabelled murine monoclonal antibody 81C6 and its Fab fragment in human glioma xenografts in athymic mice.

Journal Article Br J Neurosurg · 1988 The localisation of the radioiodinated Fab fragment of monoclonal antibody (Mab) 81C6, reactive with a glioma-associated extracellular matrix antigen, was studied in athymic mice bearing subcutaneous and intracranial xenografts of D-54 MG glioma cells. In ... Full text Link to item Cite

Structural chromosomal abnormalities in human medulloblastoma.

Journal Article Cancer Genet Cytogenet · January 1988 Seven human medulloblastomas (four primary cerebellar, three recurrent or metastatic) were karyotyped in direct preparation and/or short-term or early culture. One tumor had a 46,XX stem line. Four of the six remaining tumors contained one or more i(17q), ... Full text Link to item Cite

Efficacy of intravenous gamma globulin in autoimmune-mediated pediatric blood dyscrasias.

Journal Article Am J Med · October 23, 1987 Sixteen pediatric patients diagnosed with a variety of autoimmune-mediated hematocytopenias were treated with one to 50 courses of intravenous gamma globulin (IVIG), pH 4.25, over the course of one to 30 months. Thirteen patients had immune thrombocytopeni ... Full text Link to item Cite

Treatment of platelet alloimmunization with intravenous immunoglobulin. Two case reports and review of the literature.

Journal Article Am J Med · October 23, 1987 Two pediatric patients with severe aplastic anemia, elevated antiplatelet antibody levels, refractoriness to human lymphocyte antigen-matched platelet transfusions, and sustained bleeding problems were treated with intravenous immunoglobulin (IVIG), pH 4.2 ... Full text Link to item Cite

Effects of alcohol on experimental atrial fibrillation.

Journal Article Alcohol Clin Exp Res · October 1987 The association of alcohol abuse, especially binge drinking, and atrial fibrillation, recently termed "holiday heart," has been recognized for some time. The effects of alcohol on atrial fibrillation, however, have not been studied. Accordingly, measuremen ... Full text Link to item Cite

Personality, type A behavior, and coronary heart disease: the role of emotional expression.

Journal Article J Pers Soc Psychol · October 1987 The nature of the relation between personality factors and coronary heart disease (CHD, the nation's greatest killer) is one of the most important if controversial issues in the field of psychology and health. Although there is still a great deal of concep ... Full text Link to item Cite

Therapeutic profile of the human glioma line D-54 MG in athymic mice.

Journal Article Cancer Treat Rep · September 1987 We treated D-54 MG, an extensively characterized human glioma tumor line, in athymic mice with each of 20 antineoplastic drugs and two radiation doses. PCNU, melphalan, cyclophosphamide, and fludarabine were highly active against sc tumors. A single radiat ... Link to item Cite

Urinary digoxin-like immunoreactive substance in pregnancy. Relation to urinary electrolytes.

Journal Article Am J Med · August 1987 High concentrations of digoxin-like immunoreactive substance (DLIS) have been identified in amniotic fluid and in blood during pregnancy. In this study, urine from healthy women was analyzed for DLIS during pregnancy and following delivery, and levels were ... Full text Link to item Cite

Simultaneous measurements of blood flow and blood-to-tissue transport in xenotransplanted medulloblastomas.

Journal Article Cancer Res · March 15, 1987 We used double-label quantitative autoradiography to study blood flow (with [131I]iodoantipyrine) and blood-to-tissue transport (with [14C]-alpha-aminoisobutyric acid) in 20 TE-671 medulloblastomas xenotransplanted into nude rats. Microscopically, two dist ... Link to item Cite

Phase II diaziquone-based chemotherapy trials in patients with anaplastic supratentorial astrocytic neoplasms.

Journal Article J Clin Oncol · March 1987 We treated 103 patients with histologically confirmed anaplastic supratentorial astrocytic neoplasms with either diaziquone (AZQ) and carmustine (BCNU) or AZQ and procarbazine. There were 74 patients with glioblastoma multiforme (GBM) and 29 patients with ... Full text Link to item Cite

THERAPEUTIC SYNERGY OF THIOPURINES AND ALKYLATING DRUGS IN A HUMAN GLIOMA XENOGRAFT

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · March 1, 1987 Link to item Cite

AMPLIFICATION AND EXPRESSION OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR (EGFR) GENE IN HUMAN GLIOMA (HGL) XENOGRAFTS

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · March 1, 1987 Link to item Cite

MELPHALAN CYTOTOXICITY AND RESISTANCE IN MEDULLOBLASTOMA (MBT)

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · March 1, 1987 Link to item Cite

A rapidly dividing human medulloblastoma cell line (D283 MED) expresses all three neurofilament subunits.

Journal Article Am J Pathol · February 1987 The majority of cells in a rapidly dividing human medulloblastoma cell line (D283 MED) are shown to express the two high-molecular-weight human neurofilament (NF) subunits, whereas a minority express the low-molecular-weight NF subunit. These three polypep ... Link to item Cite

The chemotherapy of posterior fossa tumors in childhood.

Journal Article J Neurooncol · 1987 Conventional therapy for brain tumors, consisting of neurosurgical intervention and radiotherapy, has not resulted in the successes achievable in other childhood malignancies. The role of adjuvant chemotherapy, well defined in many childhood cancers, has n ... Full text Link to item Cite

Psychosocial factors in sunbathing and sunscreen use.

Journal Article Health Psychol · 1987 Excessive exposure to the sun has been related to the development of various types of skin cancer, but use of sunscreen decreases the risk. The present project was designed to empirically examine psychosocial factors in sunbathing and sunscreen use. One hu ... Full text Link to item Cite

Recurrent brain tumors in children.

Journal Article Pediatr Neurosci · 1987 A significant cohort of children with central nervous system tumors will fail initial therapeutic intervention and demonstrate recurrent disease. Treatment of children with these recurrent tumors requires a comprehensive multidisciplinary approach, with co ... Full text Link to item Cite

Treatment of lymphohistiocytic erythrophagocytosis with VP-16 and aziridinylbenzoquinone.

Journal Article Med Pediatr Oncol · 1987 Lymphohistiocytic erythrophagocytosis (LE) is a usually fatal disease characterized by fever, organomegaly, hyperlipidemia, central nervous system involvement, and cellular immunodeficiency. Treatment with corticosteroids, cytotoxic chemotherapy, and blood ... Full text Link to item Cite

The effects of atrial fibrillation on regional blood flow in the awake dog.

Journal Article Can J Cardiol · 1987 To determine the acute effects of atrial fibrillation on regional blood flow, measurements were made in awake dogs with this arrhythmia induced and sustained by rapid atrial stimulation. Atrial fibrillation reduced cardiac output (from 3.7 +/- 0.3 to 3.0 + ... Link to item Cite

Bacterial endocarditis in a child with a Broviac catheter.

Journal Article Pediatr Hematol Oncol · 1987 Broviac and Hickman catheters facilitate the care of children with cancer but provide a source of potential infection. We describe a child with a Broviac catheter who developed left-sided bacterial endocarditis in whom right-to-left atrial shunting was doc ... Full text Link to item Cite

Management of human immunodeficiency virus-associated thrombocytopenia with intravenous gamma globulin.

Journal Article Am J Pediatr Hematol Oncol · 1987 A 17-month-old boy in whom immune-mediated thrombocytopenia (ITP) was the presenting manifestation of infection with human immunodeficiency virus (HIV) is being successfully managed with intermittent high-dose intravenous gamma globulin (IVIG) allowing mai ... Full text Link to item Cite

Treatment of trilateral retinoblastoma with vincristine and cyclophosphamide.

Journal Article Am J Ophthalmol · November 15, 1986 Current therapy for patients with trilateral retinoblastoma, consisting primarily of surgical intervention and radiotherapy, has resulted in no long-term survivors. The use of adjuvant chemotherapy has not improved this outcome. After observing a tumor res ... Full text Link to item Cite

Experimental chemotherapy of human medulloblastoma with classical alkylators.

Journal Article Cancer Res · June 1986 Seven classical alkylators were tested for activity against the continuous human medulloblastoma cell line TE-671 grown in vitro and as s.c. and intracranial xenografts in athymic mice. Drugs tested included melphalan, cyclophosphamide (4-hydroperoxycyclop ... Link to item Cite

Characterization of new gangliosides of the lactotetraose series in murine xenografts of a human glioma cell line.

Journal Article FEBS Lett · May 26, 1986 The major mono- and disialogangliosides of the extensively characterized established human glioma line D54MG were isolated and purified from subcutaneous solid xenografts grown in athymic (nu/nu) mice. Structural determination showed that they belonged to ... Full text Link to item Cite

9p- in a girl with acute lymphocytic leukemia and sickle cell disease.

Journal Article Cancer Genet Cytogenet · April 1, 1986 A 4 year old girl with sickle cell disease developed acute lymphocytic leukemia null cell type. The bone marrow karyotype was 46,XX,del(9)(p13). This girl is among the few patients with acute lymphocytic leukemia and abnormalities of #9 to have an isolated ... Full text Link to item Cite

Efficacy of vincristine and cyclophosphamide in the therapy of recurrent medulloblastoma.

Journal Article Neurosurgery · March 1986 We conducted a Phase II study of combination therapy with vincristine and cyclophosphamide in the treatment of patients with recurrent or metastatic medulloblastoma. Fourteen patients were treated with vincristine 2 mg/m2 (2.0-mg maximal dose) by intraveno ... Full text Link to item Cite

CHEMOTHERAPY OF HUMAN MEDULLOBLASTOMA WITH CLASSICAL ALKYLATORS

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · March 1, 1986 Link to item Cite

KARYOTYPIC FINDINGS IN 6 CASES OF HUMAN MEDULLOBLASTOMA

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · March 1, 1986 Link to item Cite

LOCALIZATION OF ANTI-HUMAN GLIOMA MONOCLONAL-ANTIBODIES (MABS) IN SUBCUTANEOUS (SC) AND INTRACEREBRAL (IC) GLIOMA XENOGRAFTS

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · March 1, 1986 Link to item Cite

Impression formation: the role of expressive behavior.

Journal Article J Pers Soc Psychol · February 1986 This research examined the effects of personality/social skills and individual differences in expressive style on impression formation. Particular attention was given to the role of nonverbal behaviors in the formation of initial impressions. Sixty-two sub ... Full text Link to item Cite

Cardiac function in alcohol-associated systemic hypertension.

Journal Article Am J Cardiol · February 1, 1986 The pathogenesis of alcohol cardiomyopathy is obscure. Because systemic hypertension is observed in one-third of alcoholics, the relation of this finding to left ventricular (LV) function was analyzed in 66 alcoholics (26 with a blood pressure of 160/95 mm ... Full text Link to item Cite

Primary brain tumours in Fischer 344 rats chronically exposed to acrylonitrile in their drinking-water.

Journal Article Food Chem Toxicol · February 1986 Acrylonitrile (ACN) has been tested for carcinogenicity by various routes in a number of rat strains. At relatively high levels of administration (e.g. 500 ppm in the drinking-water) there were statistically significant increases in microscopically detecta ... Full text Link to item Cite

Severe Mycoplasma pneumonia in three sisters with sickle cell disease.

Journal Article Pediatr Hematol Oncol · 1986 Mycoplasma pneumoniae, which usually causes mild infections in normal children, has been shown to cause isolated cases of severe pneumonia in children with sickle cell disease. We recently observed an outbreak of Mycoplasma pneumonia in three sisters with ... Full text Link to item Cite

Prognostic implications for direct platelet-associated IgG in childhood idiopathic thrombocytopenic purpura.

Journal Article Am J Pediatr Hematol Oncol · 1986 To determine the value of the direct platelet associated IgG (PAIgG) level as a prognostic indicator in childhood idiopathic thrombocytopenia purpura (ITP), 18 children with ITP were studied. Ten of the 18 had PAIgG levels measured at diagnosis, before any ... Full text Link to item Cite

Specific chromosomal abnormalities characterize four established cell lines derived from malignant human gliomas.

Journal Article Acta Neuropathol · 1986 The four permanent human glioma-derived cell lines reported here are the first such lines for which the karyotypes have been followed from the original biopsies through the establishment of the lines in culture. Although ploidy changes were seen, each line ... Full text Link to item Cite

Chemotherapy of subcutaneous and intracranial human medulloblastoma xenografts in athymic nude mice.

Journal Article Cancer Res · January 1986 The continuous human medulloblastoma cell line TE-671 was grown as s.c. and intracranial xenografts in athymic nude mice. Tumor-bearing animals were treated with chemotherapeutic agents at the 10% lethal dose; s.c. xenografts were sensitive to melphalan, 1 ... Link to item Cite

ACRYLONITRILE NEUROONCOGENESIS IN F344 RATS

Journal Article JOURNAL OF NEURO-ONCOLOGY · January 1, 1986 Link to item Cite

COOPERATIVE STUDIES OF CHEMOTHERAPY FOR GLIOMAS AND MEDULLOBLASTOMAS

Journal Article JOURNAL OF NEURO-ONCOLOGY · January 1, 1986 Link to item Cite

Pharmacokinetics of diaziquone after three different dosage regimens.

Journal Article Cancer Treat Rep · December 1985 Diaziquone (AZQ) is a benzoquinone derivative exhibiting significant effects against CNS tumors. This study investigates the pharmacokinetics of AZQ for three different durations of continuous iv infusions, over 20 mins, 4 hrs, and 6 hrs, in nine patients ... Link to item Cite

Rational approaches to the chemotherapy of medulloblastoma.

Journal Article Neurol Clin · November 1985 Medulloblastoma is the most common primary tumor of the CNS in childhood. Surgical intervention alone will not cure this tumor, and the addition of whole neuraxis irradiation has led to a 50 to 60 per cent, 5-year survival. The role of adjuvant chemotherap ... Link to item Cite

Establishment and characterization of the human medulloblastoma cell line and transplantable xenograft D283 Med.

Journal Article J Neuropathol Exp Neurol · November 1985 A new continuous cell line and transplantable xenograft, D283 Med, was derived from the peritoneal implant and ascitic fluid of a child with metastatic medulloblastoma and grew in vitro in suspension culture with spontaneous macroscopic spheroid formation. ... Full text Link to item Cite

The effects of atrial fibrillation on myocardial blood flow and energetics.

Journal Article Proc Soc Exp Biol Med · October 1985 The changes produced by atrial fibrillation on myocardial blood flow and energetics are unclear. Accordingly, the effects of atrial fibrillation on myocardial blood flow and oxygen consumption were studied in 18 anesthetized dogs. With atrial fibrillation ... Full text Link to item Cite

Criteria and definitions for response and relapse in children with brain tumors.

Journal Article Cancer · October 1, 1985 Traditional criteria and definitions for response and relapse are not completely suitable for children with brain tumors. Response and relapse for brain tumors need to be defined using the most objective criteria available, that is, the computed tomography ... Full text Link to item Cite

Effect of glutamate analogues on brain tumor cell lines.

Journal Article J Neurochem · October 1985 Glutamate analogues have been used in many different experimental approaches in neurobiology. A small number of these analogues have been classified as gliotoxic. We have examined the effect of seven glutamate analogues (five gliotoxic and two neurotoxic) ... Full text Link to item Cite

Combination chemotherapy in vitro exploiting glutamine metabolism of human glioma and medulloblastoma.

Journal Article Cancer Res · September 1985 The human glioma-derived cell line D-54 MG and the human medulloblastoma-derived cell line TE-671 have been shown to be sensitive in culture to the pharmacological interference with glutamine metabolism by acivicin, 6-diazo-5-oxo-L-norleucine, and methioni ... Link to item Cite

Influence of glutamine on the growth of human glioma and medulloblastoma in culture.

Journal Article Cancer Res · September 1985 Cellular supply of glutamine, an essential substrate for growth, is derived from extracellular fluid and de novo synthesis. We investigated the relative importance of these sources to the growth of six human anaplastic glioma- and one human medulloblastoma ... Link to item Cite

Infectious and bleeding complications in patients with glycogenosis Ib.

Journal Article Am J Dis Child · July 1985 Clinical, hematologic, and immunologic findings were reviewed in 21 patients with glycogenosis Ib. Fifteen of the patients suffered from moderate to severe bacterial infections. Ten patients had excessive epistaxis or bleeding from surgical sites, and eigh ... Full text Link to item Cite

Type A behavior, nonverbal expressive style, and health.

Journal Article J Pers Soc Psychol · May 1985 Understanding the precise nature of the links among styles of behavior, emotional expression, and the development of heart disease is a major challenge in psychology and health. In the present research, 60 men at high risk for coronary heart disease were e ... Full text Link to item Cite

Hypertension associated with alcohol withdrawal: assessment of mechanisms and complications.

Journal Article Alcohol Clin Exp Res · 1985 Two hundred and fifty-six consecutive alcoholics admitted for detoxification, but not having delirium tremens, were evaluated for hypertension. Thirty-three per cent (84) of the alcoholics had a blood pressure greater than or equal to 160/95 mm Hg on or wi ... Full text Link to item Cite

Sensitivity of human medulloblastoma (MED) to classical alkylators

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1985 Cite

Glutamine based combination chemotherapy in culture for human glioma and medulloblastoma

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1985 Cite

SENSITIVITY OF HUMAN MEDULLOBLASTOMA (MED) TO CLASSICAL ALKYLATORS

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · January 1, 1985 Link to item Cite

GLUTAMINE BASED COMBINATION CHEMOTHERAPY IN CULTURE FOR HUMAN GLIOMA AND MEDULLOBLASTOMA

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · January 1, 1985 Link to item Cite

Management of solid tumors in children.

Journal Article Compr Ther · November 1984 Link to item Cite

In vitro versus in vivo correlations of chemosensitivity of human medulloblastoma.

Journal Article Cancer Res · November 1984 An in vitro clonogenic assay was used to test the chemosensitivity of the human medulloblastoma cell line TE-671. Dose-response relationships for reduction in colony formation were generated for cyclophosphamide, vincristine, Adriamycin, 1,3-bis(2-chloroet ... Link to item Cite

Effects of atrial fibrillation on myocardial blood flow in the ischemic heart of the dog.

Journal Article J Am Coll Cardiol · October 1984 Atrial fibrillation has a variable effect on myocardial blood flow in the intact heart. To assess its action on myocardial blood flow in the ischemic heart, measurements were made in nine dogs after ligation of the left anterior descending coronary artery ... Full text Link to item Cite

Indications for pacing in the treatment of bradyarrhythmias. Report of an independent study group.

Journal Article JAMA · September 14, 1984 Indications for permanent pacing in the bradyarrhythmias are summarized. In the absence of symptoms, pacing is justified only when Mobitz type II block or complete atrioventricular (AV) block is localized in the bundle-branch system. All other abnormalitie ... Link to item Cite

Prolonged sinoatrial pauses.

Journal Article Int J Cardiol · July 1984 Full text Link to item Cite

Toxocara antigen and mitogen-induced lymphocyte blastogenesis for diagnosis of visceral larva migrans: clinical and experimental findings in macaques and human beings.

Journal Article Am J Vet Res · June 1984 Peripheral lymphocytes from macaques inoculated with Toxocara canis and from children with serologically confirmed visceral larva migrans (VLM) were assayed for blastogenic responses using Toxocara antigen and standard mitogens. Macaques were given single ... Link to item Cite

Treatment of human glioma and medulloblastoma tumor lines in athymic mice with diaziquone and diaziquone-based drug combinations.

Journal Article Cancer Res · June 1984 We used diaziquone (NSC 182986) alone and in combination with other antineoplastic drugs to treat six human glioma and one human medulloblastoma tumor lines growing s.c. in athymic mice. Pharmacokinetic studies of diaziquone in the plasma of athymic mice i ... Link to item Cite

Treatment of patients with recurrent primary brain tumors with AZQ.

Journal Article Neurology · May 1984 We have evaluated the efficacy of intravenous 2,5-diaziridinyl-3,6-biscarboethoxyamino-1,4-benzoquinone (diaziquone or AZQ, NSC-182986) in the treatment of recurrent primary anaplastic brain tumors. Three of 16 evaluable patients (18.8%) showed clinical an ... Full text Link to item Cite

130 INFLUENCE OF GLUTAMINE ON GROWTH OF HUMAN MEDULLOBLASTOMA IN CULTURE

Journal Article Journal of Neuropathology and Experimental Neurology · May 1984 Full text Cite

Retinoblastoma metastatic to bone marrow. A case with florid spread.

Journal Article Clin Pediatr (Phila) · March 1984 A 28-month-old white male, 7 months status postenucleation for retinoblastoma, presented with lethargy, irritability, anemia, and thrombocytopenia. Bone marrow examination revealed almost total replacement of marrow elements with clumps of small round baso ... Full text Link to item Cite

Human brain tumor xenografts.

Journal Article Prog Exp Tumor Res · 1984 Full text Link to item Cite

The effects of ethanol on brain blood flow in awake dogs.

Journal Article J Cardiovasc Pharmacol · 1984 Ethanol produces a generalized decline in brain flow in awake dogs. The reduction in flow is most marked and persistent in the cerebellum. In the anesthetized animal with brain blood flow already depressed, this effect is obscured. The possible relationshi ... Full text Link to item Cite

THE USE OF HUMAN MEDULLOBLASTOMA MODELS TO DESIGN RATIONAL THERAPY

Journal Article JOURNAL OF NEURO-ONCOLOGY · January 1, 1984 Link to item Cite

INVITRO AND INVIVO CHEMOSENSITIVITY OF HUMAN MEDULLOBLASTOMA

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · January 1, 1984 Link to item Cite

GLUTAMINE REQUIREMENTS OF HUMAN GLIOMA AND MEDULLOBLASTOMA IN CULTURE

Journal Article JOURNAL OF NEURO-ONCOLOGY · January 1, 1984 Link to item Cite

The effects of ethanol on pancreatic blood flow in awake and anesthetized dogs.

Journal Article Proc Soc Exp Biol Med · December 1983 The pathophysiology of alcohol-induced acute pancreatitis is not clear. Ischemic injury has been suggested as a possible mechanism. To examine the effects of ethanol on pancreatic and splanchnic blood flow, measurements were made in fasted, conditioned awa ... Full text Link to item Cite

Hemodynamic changes during hemodialysis: role of dialyzate.

Journal Article Clin Nephrol · October 1983 To determine the contribution of the dialyzate to the hemodynamic changes that occur during hemodialysis, echocardiographic measurements obtained during identical conditions of hemodialysis except for the use of different dialyzates were compared. With an ... Link to item Cite

A model for human medulloblastoma. Growth, morphology, and chromosomal analysis in vitro and in athymic mice.

Journal Article J Neuropathol Exp Neurol · September 1983 A model was developed for the in vitro and in vivo study of the continuous cell line, TE-671, derived from a human medulloblastoma. TE-671 grew in vitro as sheets of uniform triangular- to spindle-shaped cells with round to oval nuclei and sparse cytoplasm ... Full text Link to item Cite

Propionibacterium shunt nephritis in two adolescents with medulloblastoma.

Journal Article Cancer · July 15, 1983 The anaerobic diphtheroid Propionibacterium acnes was identified as the organism responsible for "shunt" nephritis in two adolescents with ventriculoatrial shunts inserted previously for the management of medulloblastoma. Only three cases of "shunt" nephri ... Full text Link to item Cite

Chemotherapy and radiation therapy of human medulloblastoma in athymic nude mice.

Journal Article Cancer Res · July 1983 The human medulloblastoma cell line TE-671 was grown s.c. and intracranially in athymic nude mice. Tumor-bearing animals treated with chemotherapeutic agents or radiation were compared to untreated tumor-bearing controls. Tumors growing s.c. were sensitive ... Link to item Cite

Use of control steady-state serum digoxin levels for predicting serum digoxin concentration after quinidine administration.

Journal Article Am Heart J · July 1982 Serum digoxin and/quinidine concentration were measured before and following the institution of quinidine therapy in 11 patients who were receiving maintenance oral digoxin therapy and who required quinidine therapy for suppression of extrasystoles. Steady ... Full text Link to item Cite

Case 1-1982: Atrioventricular heart block.

Journal Article N Engl J Med · June 10, 1982 Full text Link to item Cite

Treatment of human brain tumors in athymic mice with aziridinylbenzoquinone (AZQ)

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1982 Cite

TREATMENT OF HUMAN-BRAIN TUMORS IN ATHYMIC MICE WITH AZIRIDINYLBENZOQUINONE (AZQ)

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · January 1, 1982 Link to item Cite

Central nervous system leukaemia.

Journal Article Lancet · September 19, 1981 Full text Link to item Cite

Impact of peer review in reduction of permanent pacemaker implantations.

Journal Article JAMA · August 14, 1981 Because of a sharp increase in the number of permanent pacemakers inserted at The Brooklyn Hospital between 1972 and 1976, a peer-review committee was established to monitor subsequent pacemaker implantation. Total initial implants declined from 48 to 22 p ... Link to item Cite

Insulin infusion in ketolactic acidosis complicating malignancy

Journal Article Clinical Research · January 1, 1981 Cite

Alteration of digoxin pharmacokinetics by a single dose of quinidine.

Journal Article JAMA · August 15, 1980 To determine whether a single dose of quinidine sulfate might alter serum digoxin levels, patients receiving maintenance digoxin therapy who required quinidine had their serum digoxin levels measured after oral administration of digoxin, quinidine, or both ... Link to item Cite

Predicting patient satisfaction from physicians' nonverbal communication skills.

Journal Article Med Care · April 1980 The relationship between physicians' nonverbal communication skills (their ability to communicate and to understand facial expression, body movement and voice tone cues to emotion) and their patients' satisfaction with medical care was examined in 2 studie ... Full text Link to item Cite

Procainamide-induced sinus node dysfunction in patients with chronic renal failure.

Journal Article Chest · December 1979 Two patients with chronic renal failure developed transient sinus node dysfunction requiring insertion of a temporary pacemaker while receiving procainamide to control ventricular arrhythmias. Blood levels of procainamide were found to be elevated, althoug ... Full text Link to item Cite

Demonstration of dissimilar acute haemodynamic effects of ethanol and acetaldehyde.

Journal Article Cardiovasc Res · August 1979 To determine whether the acute cardiac depressant effects of ethanol could be attributed to its metabolite (acetaldehyde), either ethanol or acetaldehyde was intravenously infused into pentobarbital anaesthetised, closed-chest dogs. At a venous blood ethan ... Full text Link to item Cite

Hemodynamic changes during dialysis.

Journal Article Proc Clin Dial Transplant Forum · 1979 Link to item Cite

Changing diastolic closure rates (E to F slopes) in a patient with mitral stenosis: a case report.

Journal Article Angiology · January 1979 A patient with mitral stenosis and atrial flutter was found to have a normal diastolic closure rate (E to F slope). Following cardioversion, the typical echocardiographic features of mitral stenosis were found. After various interventions that increased he ... Full text Link to item Cite

Cardiac tamponade.

Journal Article Circulation · January 1979 Full text Link to item Cite

Assessment of atrioventricular conduction in aortic valve disease.

Journal Article Br Heart J · August 1978 To determine the frequency of atrioventricular conduction disturbances in aortic valve disease, 26 consecutive patients (age 54 +/- 2 years) with symptomatic aortic valve disease were studied by His bundle electrocardiography at the time of cardiac cathete ... Full text Link to item Cite

Persistent repetitive supraventricular tachycardia.

Journal Article Eur J Cardiol · July 1977 A case of persistent repetitive supraventricular tachycardia known to be present for at least 9 yr is reported. Although the patient appeared to tolerate the arrhythmia without any ill effects he was found to have moderate left ventricular dysfunction due ... Link to item Cite

Demonstration of a depressor reflex in acute cardiac tamponade.

Journal Article J Thorac Cardiovasc Surg · February 1977 Studies from our laboratory have demonstrated the presence of a vagally mediated reflex in acute cardiac tamponade. To determine the effect of thisreflex on cardiac performance, we continuously recorded hemodynamic parameters during induction of tamponade ... Link to item Cite

Effect of autonomic blockade on the hemodynamic findings in acute cardiac tamponade.

Journal Article Am J Physiol · January 1977 Twenty-three closed-chest, alpha-chloralose-anesthetized, volume-expanded, alpha- and beta-adrenergic-blockaded dogs with rate fixed by atrial pacing had 30-90 ml of saline at 37 degrees C infused into the pericardial sac a) with vagus intact, b) after vag ... Full text Link to item Cite

Effective time management: a key to increased sales.

Journal Article Dent Lab Rev · January 1977 Link to item Cite

Sarcoidosis with incomplete bilateral bundle branch block pattern disappearing following steroid therapy: an electrophysiological study.

Journal Article Eur J Cardiol · June 1976 A man with a 30-year history of pulmonary sarcoidosis, confirmed by lymph node biopsy and a positive Kveim reaction, developed an incomplete bilateral bundle branch block pattern. Cardiac catherization and angiography revealed normal pressures, hemodynamic ... Link to item Cite

Effects of self-esteem and expected duration of interaction on liking for a highly rewarding partner.

Journal Article J Pers Soc Psychol · June 1976 Psychological theories predicated on the assumption of human selfishness and theories based on principles of equity may lead to conflicting predictions about when a person will like his partner. Of special interest are a person's reactions to receiving unc ... Full text Link to item Cite

An analysis of Wenckebach periodicity.

Journal Article J Electrocardiol · 1975 His bundle electrograms of 40 patients developing Wenckebach block during atrial pacing and four with spontaneous Wenckebach block above the His were reviewed to determine the frequency of classical Wenckebach periodicity. Thirty patients had 143 Wenckebac ... Full text Link to item Cite