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Andrew Berchuck

James M. Ingram Distinguished Professor of Gynecologic Oncology
Obstetrics and Gynecology, Gynecologic Oncology
Box 3079 Med Ctr, Durham, NC 27710
25171 Morris Bldg, Durham, NC 27710

Selected Publications


Periostin facilitates ovarian cancer recurrence by enhancing cancer stemness.

Journal Article Sci Rep · December 4, 2023 The lethality of epithelial ovarian cancer (OC) is largely due to a high rate of recurrence and development of chemoresistance, which requires synergy between cancer cells and the tumor microenvironment (TME) and is thought to involve cancer stem cells. Ou ... Full text Open Access Link to item Cite

Lifetime ovulatory years and risk of epithelial ovarian cancer: a multinational pooled analysis.

Journal Article J Natl Cancer Inst · May 8, 2023 BACKGROUND: The role of ovulation in epithelial ovarian cancer (EOC) is supported by the consistent protective effects of parity and oral contraceptive use. Whether these factors protect through anovulation alone remains unclear. We explored the associatio ... Full text Link to item Cite

Health-care access dimensions and ovarian cancer survival: SEER-Medicare analysis of the ORCHiD study.

Journal Article JNCI Cancer Spectr · March 1, 2023 BACKGROUND: Racial and ethnic disparities in ovarian cancer (OC) survival are well-documented. However, few studies have investigated how health-care access (HCA) contributes to these disparities. METHODS: To evaluate the influence of HCA on OC mortality, ... Full text Link to item Cite

Factor Analysis of Health Care Access With Ovarian Cancer Surgery and Gynecologic Oncologist Consultation.

Journal Article JAMA Netw Open · February 1, 2023 IMPORTANCE: Poor health care access (HCA) is associated with racial and ethnic disparities in ovarian cancer (OC) survival. OBJECTIVE: To generate composite scores representing health care affordability, availability, and accessibility via factor analysis ... Full text Link to item Cite

Association of Frequent Aspirin Use With Ovarian Cancer Risk According to Genetic Susceptibility.

Journal Article JAMA Netw Open · February 1, 2023 IMPORTANCE: Frequent aspirin use is associated with reduced ovarian cancer risk, but it is unknown whether genetic factors modify this association. Understanding effect modifiers is important given that any use of aspirin for ovarian cancer chemoprevention ... Full text Link to item Cite

Concordance Between Genomic Alterations Detected by Tumor and Germline Sequencing: Results from a Tertiary Care Academic Center Molecular Tumor Board.

Journal Article Oncologist · January 18, 2023 OBJECTIVE: The majority of tumor sequencing currently performed on cancer patients does not include a matched normal control, and in cases where germline testing is performed, it is usually run independently of tumor testing. The rates of concordance betwe ... Full text Open Access Link to item Cite

Healthcare Access Domains Mediate Racial Disparities in Ovarian Cancer Treatment Quality in a US Patient Cohort: A Structural Equation Modelling Analysis.

Journal Article Cancer Epidemiol Biomarkers Prev · January 9, 2023 BACKGROUND: Ovarian cancer survival disparities have persisted for decades, driven by lack of access to quality treatment. We conducted structural equation modeling (SEM) to define latent variables representing three healthcare access (HCA) domains: afford ... Full text Link to item Cite

Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study.

Journal Article Br J Cancer · January 2023 BACKGROUND: Recently, we showed a >60% difference in 5-year survival for patients with tubo-ovarian high-grade serous carcinoma (HGSC) when stratified by a 101-gene mRNA expression prognostic signature. Given the varied patient outcomes, this study aimed t ... Full text Link to item Cite

Modification of the Association Between Frequent Aspirin Use and Ovarian Cancer Risk: A Meta-Analysis Using Individual-Level Data From Two Ovarian Cancer Consortia.

Journal Article J Clin Oncol · December 20, 2022 PURPOSE: Frequent aspirin use has been associated with reduced ovarian cancer risk, but no study has comprehensively assessed for effect modification. We leveraged harmonized, individual-level data from 17 studies to examine the association between frequen ... Full text Link to item Cite

Development and Psychometric Evaluation of Healthcare Access Measures among Women with Ovarian Cancer.

Journal Article Cancers (Basel) · December 19, 2022 Several proposed theoretical frameworks have defined the complex nature of healthcare access (HCA) [...]. ... Full text Link to item Cite

Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes.

Journal Article Clin Cancer Res · December 15, 2022 PURPOSE: Advanced-stage mucinous ovarian carcinoma (MOC) has poor chemotherapy response and prognosis and lacks biomarkers to aid stage I adjuvant treatment. Differentiating primary MOC from gastrointestinal (GI) metastases to the ovary is also challenging ... Full text Link to item Cite

Race, Affordability and Utilization of Supportive Care in Ovarian Cancer Patients.

Journal Article J Pain Symptom Manage · December 2022 OBJECTIVE: Lack of access to supportive care (SC) among cancer patients have been well documented. However, the role of affordability in this disparity among ovarian cancer (OC) patients remain poorly understood. METHODS: Patients with OC between 2008 and ... Full text Link to item Cite

Copy Number Variants Are Ovarian Cancer Risk Alleles at Known and Novel Risk Loci.

Journal Article J Natl Cancer Inst · November 14, 2022 BACKGROUND: Known risk alleles for epithelial ovarian cancer (EOC) account for approximately 40% of the heritability for EOC. Copy number variants (CNVs) have not been investigated as EOC risk alleles in a large population cohort. METHODS: Single nucleotid ... Full text Link to item Cite

Effects of risk factors for ovarian cancer in women with and without endometriosis.

Journal Article Fertil Steril · November 2022 OBJECTIVE: To evaluate the associations between 10 well-established ovarian cancer risk factors and risk of ovarian cancer among women with vs. without endometriosis. DESIGN: Pooled analysis of 9 case-control studies in the Ovarian Cancer Association Conso ... Full text Link to item Cite

Healthcare Access Dimensions and Guideline-Concordant Ovarian Cancer Treatment: SEER-Medicare Analysis of the ORCHiD Study.

Journal Article J Natl Compr Canc Netw · November 2022 BACKGROUND: Racial disparities exist in receipt of guideline-concordant treatment of ovarian cancer (OC). However, few studies have evaluated how various dimensions of healthcare access (HCA) contribute to these disparities. METHODS: We analyzed data from ... Full text Link to item Cite

Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer.

Journal Article Cell Rep · July 26, 2022 Growth factors in tumor environments are regulators of cell survival and metastasis. Here, we reveal the dichotomy between TGF-β superfamily growth factors BMP and TGF-β/activin and their downstream SMAD effectors. Gene expression profiling uncovers SOX2 a ... Full text Link to item Cite

G6PD inhibition sensitizes ovarian cancer cells to oxidative stress in the metastatic omental microenvironment.

Journal Article Cell Rep · June 28, 2022 Ovarian cancer (OC) is the most lethal gynecological malignancy, with aggressive metastatic disease responsible for the majority of OC-related deaths. In particular, OC tumors preferentially metastasize to and proliferate rapidly in the omentum. Here, we s ... Full text Link to item Cite

Hypoxia-induced inhibin promotes tumor growth and vascular permeability in ovarian cancers.

Journal Article Commun Biol · June 2, 2022 Hypoxia, a driver of tumor growth and metastasis, regulates angiogenic pathways that are targets for vessel normalization and ovarian cancer management. However, toxicities and resistance to anti-angiogenics can limit their use making identification of new ... Full text Link to item Cite

Racial Differences in the Tumor Immune Landscape and Survival of Women with High-Grade Serous Ovarian Carcinoma.

Journal Article Cancer Epidemiol Biomarkers Prev · May 4, 2022 BACKGROUND: Tumor-infiltrating lymphocytes (TIL) confer a survival benefit among patients with ovarian cancer; however, little work has been conducted in racially diverse cohorts. METHODS: The current study investigated racial differences in the tumor immu ... Full text Link to item Cite

CA-125 Levels Are Predictive of Survival in Low-Grade Serous Ovarian Cancer-A Multicenter Analysis.

Journal Article Cancers (Basel) · April 13, 2022 OBJECTIVE: Studies on low-grade serous ovarian cancer (LGSC) are limited by a low number of cases. The aim of this study was to define the prognostic significance of age, stage, and CA-125 levels on survival in a multi-institutional cohort of women with pa ... Full text Link to item Cite

Periostin facilitates ovarian cancer recurrence by enhancing cancer stemness.

Journal Article Sci Rep · December 4, 2023 The lethality of epithelial ovarian cancer (OC) is largely due to a high rate of recurrence and development of chemoresistance, which requires synergy between cancer cells and the tumor microenvironment (TME) and is thought to involve cancer stem cells. Ou ... Full text Open Access Link to item Cite

Lifetime ovulatory years and risk of epithelial ovarian cancer: a multinational pooled analysis.

Journal Article J Natl Cancer Inst · May 8, 2023 BACKGROUND: The role of ovulation in epithelial ovarian cancer (EOC) is supported by the consistent protective effects of parity and oral contraceptive use. Whether these factors protect through anovulation alone remains unclear. We explored the associatio ... Full text Link to item Cite

Health-care access dimensions and ovarian cancer survival: SEER-Medicare analysis of the ORCHiD study.

Journal Article JNCI Cancer Spectr · March 1, 2023 BACKGROUND: Racial and ethnic disparities in ovarian cancer (OC) survival are well-documented. However, few studies have investigated how health-care access (HCA) contributes to these disparities. METHODS: To evaluate the influence of HCA on OC mortality, ... Full text Link to item Cite

Factor Analysis of Health Care Access With Ovarian Cancer Surgery and Gynecologic Oncologist Consultation.

Journal Article JAMA Netw Open · February 1, 2023 IMPORTANCE: Poor health care access (HCA) is associated with racial and ethnic disparities in ovarian cancer (OC) survival. OBJECTIVE: To generate composite scores representing health care affordability, availability, and accessibility via factor analysis ... Full text Link to item Cite

Association of Frequent Aspirin Use With Ovarian Cancer Risk According to Genetic Susceptibility.

Journal Article JAMA Netw Open · February 1, 2023 IMPORTANCE: Frequent aspirin use is associated with reduced ovarian cancer risk, but it is unknown whether genetic factors modify this association. Understanding effect modifiers is important given that any use of aspirin for ovarian cancer chemoprevention ... Full text Link to item Cite

Concordance Between Genomic Alterations Detected by Tumor and Germline Sequencing: Results from a Tertiary Care Academic Center Molecular Tumor Board.

Journal Article Oncologist · January 18, 2023 OBJECTIVE: The majority of tumor sequencing currently performed on cancer patients does not include a matched normal control, and in cases where germline testing is performed, it is usually run independently of tumor testing. The rates of concordance betwe ... Full text Open Access Link to item Cite

Healthcare Access Domains Mediate Racial Disparities in Ovarian Cancer Treatment Quality in a US Patient Cohort: A Structural Equation Modelling Analysis.

Journal Article Cancer Epidemiol Biomarkers Prev · January 9, 2023 BACKGROUND: Ovarian cancer survival disparities have persisted for decades, driven by lack of access to quality treatment. We conducted structural equation modeling (SEM) to define latent variables representing three healthcare access (HCA) domains: afford ... Full text Link to item Cite

Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study.

Journal Article Br J Cancer · January 2023 BACKGROUND: Recently, we showed a >60% difference in 5-year survival for patients with tubo-ovarian high-grade serous carcinoma (HGSC) when stratified by a 101-gene mRNA expression prognostic signature. Given the varied patient outcomes, this study aimed t ... Full text Link to item Cite

Modification of the Association Between Frequent Aspirin Use and Ovarian Cancer Risk: A Meta-Analysis Using Individual-Level Data From Two Ovarian Cancer Consortia.

Journal Article J Clin Oncol · December 20, 2022 PURPOSE: Frequent aspirin use has been associated with reduced ovarian cancer risk, but no study has comprehensively assessed for effect modification. We leveraged harmonized, individual-level data from 17 studies to examine the association between frequen ... Full text Link to item Cite

Development and Psychometric Evaluation of Healthcare Access Measures among Women with Ovarian Cancer.

Journal Article Cancers (Basel) · December 19, 2022 Several proposed theoretical frameworks have defined the complex nature of healthcare access (HCA) [...]. ... Full text Link to item Cite

Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes.

Journal Article Clin Cancer Res · December 15, 2022 PURPOSE: Advanced-stage mucinous ovarian carcinoma (MOC) has poor chemotherapy response and prognosis and lacks biomarkers to aid stage I adjuvant treatment. Differentiating primary MOC from gastrointestinal (GI) metastases to the ovary is also challenging ... Full text Link to item Cite

Race, Affordability and Utilization of Supportive Care in Ovarian Cancer Patients.

Journal Article J Pain Symptom Manage · December 2022 OBJECTIVE: Lack of access to supportive care (SC) among cancer patients have been well documented. However, the role of affordability in this disparity among ovarian cancer (OC) patients remain poorly understood. METHODS: Patients with OC between 2008 and ... Full text Link to item Cite

Copy Number Variants Are Ovarian Cancer Risk Alleles at Known and Novel Risk Loci.

Journal Article J Natl Cancer Inst · November 14, 2022 BACKGROUND: Known risk alleles for epithelial ovarian cancer (EOC) account for approximately 40% of the heritability for EOC. Copy number variants (CNVs) have not been investigated as EOC risk alleles in a large population cohort. METHODS: Single nucleotid ... Full text Link to item Cite

Effects of risk factors for ovarian cancer in women with and without endometriosis.

Journal Article Fertil Steril · November 2022 OBJECTIVE: To evaluate the associations between 10 well-established ovarian cancer risk factors and risk of ovarian cancer among women with vs. without endometriosis. DESIGN: Pooled analysis of 9 case-control studies in the Ovarian Cancer Association Conso ... Full text Link to item Cite

Healthcare Access Dimensions and Guideline-Concordant Ovarian Cancer Treatment: SEER-Medicare Analysis of the ORCHiD Study.

Journal Article J Natl Compr Canc Netw · November 2022 BACKGROUND: Racial disparities exist in receipt of guideline-concordant treatment of ovarian cancer (OC). However, few studies have evaluated how various dimensions of healthcare access (HCA) contribute to these disparities. METHODS: We analyzed data from ... Full text Link to item Cite

Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer.

Journal Article Cell Rep · July 26, 2022 Growth factors in tumor environments are regulators of cell survival and metastasis. Here, we reveal the dichotomy between TGF-β superfamily growth factors BMP and TGF-β/activin and their downstream SMAD effectors. Gene expression profiling uncovers SOX2 a ... Full text Link to item Cite

G6PD inhibition sensitizes ovarian cancer cells to oxidative stress in the metastatic omental microenvironment.

Journal Article Cell Rep · June 28, 2022 Ovarian cancer (OC) is the most lethal gynecological malignancy, with aggressive metastatic disease responsible for the majority of OC-related deaths. In particular, OC tumors preferentially metastasize to and proliferate rapidly in the omentum. Here, we s ... Full text Link to item Cite

Hypoxia-induced inhibin promotes tumor growth and vascular permeability in ovarian cancers.

Journal Article Commun Biol · June 2, 2022 Hypoxia, a driver of tumor growth and metastasis, regulates angiogenic pathways that are targets for vessel normalization and ovarian cancer management. However, toxicities and resistance to anti-angiogenics can limit their use making identification of new ... Full text Link to item Cite

Racial Differences in the Tumor Immune Landscape and Survival of Women with High-Grade Serous Ovarian Carcinoma.

Journal Article Cancer Epidemiol Biomarkers Prev · May 4, 2022 BACKGROUND: Tumor-infiltrating lymphocytes (TIL) confer a survival benefit among patients with ovarian cancer; however, little work has been conducted in racially diverse cohorts. METHODS: The current study investigated racial differences in the tumor immu ... Full text Link to item Cite

CA-125 Levels Are Predictive of Survival in Low-Grade Serous Ovarian Cancer-A Multicenter Analysis.

Journal Article Cancers (Basel) · April 13, 2022 OBJECTIVE: Studies on low-grade serous ovarian cancer (LGSC) are limited by a low number of cases. The aim of this study was to define the prognostic significance of age, stage, and CA-125 levels on survival in a multi-institutional cohort of women with pa ... Full text Link to item Cite

Reproductive Factors Do Not Influence Survival with Ovarian Cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · April 1, 2022 BACKGROUND: Previous studies on the association between reproductive factors and ovarian cancer survival are equivocal, possibly due to small sample sizes. METHODS: Using data on 11,175 people diagnosed with primary invasive epithelial ovarian, fallopian t ... Full text Link to item Cite

High Prediagnosis Inflammation-Related Risk Score Associated with Decreased Ovarian Cancer Survival.

Journal Article Cancer Epidemiol Biomarkers Prev · February 2022 BACKGROUND: There is suggestive evidence that inflammation is related to ovarian cancer survival. However, more research is needed to identify inflammation-related factors that are associated with ovarian cancer survival and to determine their combined eff ... Full text Link to item Cite

Pleiotropic MLLT10 variation confers risk of meningioma and estrogen-mediated cancers

Conference Neuro-Oncology Advances · January 1, 2022 Background: Risk of tumors of the breast, ovary, and meninges has been associated with hormonal factors and with one another. Genome-wide association studies (GWAS) identified a meningioma risk locus on 10p12 near previous GWAS hits for breast and ovarian ... Full text Cite

Endometriosis and menopausal hormone therapy impact the hysterectomy-ovarian cancer association.

Journal Article Gynecol Oncol · January 2022 OBJECTIVE: To evaluate the association between hysterectomy and ovarian cancer, and to understand how hormone therapy (HT) use and endometriosis affect this association. METHODS: We conducted a pooled analysis of self-reported data from 11 case-control stu ... Full text Link to item Cite

Endometrial cancer

Chapter · January 1, 2022 The prior dichotomous classification of endometrial cancer into high and low risk subtypes based primarily on histology has been shown to be inadequate in predicting outcome and treatment response. More nuanced molecular categorization of these cancers pro ... Full text Cite

Endometrial Adenocarcinomas With No Specific Molecular Profile: Morphologic Features and Molecular Alterations of "Copy-number Low" Tumors.

Journal Article Int J Gynecol Pathol · November 1, 2021 The study evaluated morphologic patterns, mutational profiles, and β-catenin immunohistochemistry (IHC) in copy-number low (CNL) endometrial adenocarcinomas (EAs). CNL EAs (n=19) with next-generation or whole genome sequencing results and available tissue ... Full text Link to item Cite

Ovarian Cancer Epidemiology, Healthcare Access and Disparities (ORCHiD): methodology for a population-based study of black, Hispanic and white patients with ovarian cancer.

Journal Article BMJ Open · October 4, 2021 INTRODUCTION: Less than 40% of patients with ovarian cancer (OC) in the USA receive stage-appropriate guideline-adherent surgery and chemotherapy. Black patients with cancer report greater depression, pain and fatigue than white patients. Lack of access to ... Full text Link to item Cite

Identification of a Locus Near ULK1 Associated With Progression-Free Survival in Ovarian Cancer.

Journal Article Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · September 2021 BackgroundMany loci have been found to be associated with risk of epithelial ovarian cancer (EOC). However, although there is considerable variation in progression-free survival (PFS), no loci have been found to be associated with outcome at genom ... Full text Cite

Cardiovascular medications and survival in people with ovarian cancer: A population-based cohort study from British Columbia, Canada.

Journal Article Gynecol Oncol · August 2021 OBJECTIVES: Research examining survival among people with ovarian cancer following use of statins or β-blockers has been conflicting. Many studies to date have suffered from immortal time bias and/or had limited power. To address these limitations, we used ... Full text Link to item Cite

Pleiotropy-guided transcriptome imputation from normal and tumor tissues identifies candidate susceptibility genes for breast and ovarian cancer.

Journal Article HGG Adv · July 8, 2021 Familial, sequencing, and genome-wide association studies (GWASs) and genetic correlation analyses have progressively unraveled the shared or pleiotropic germline genetics of breast and ovarian cancer. In this study, we aimed to leverage this shared germli ... Full text Link to item Cite

Molecular Classification to Prognosticate Response in Medically Managed Endometrial Cancers and Endometrial Intraepithelial Neoplasia.

Journal Article Cancers (Basel) · June 7, 2021 BACKGROUND: The aim of this study was to evaluate whether molecular classification prognosticates treatment response in women with endometrial cancers and endometrial intraepithelial neoplasia (EIN) treated with levonorgestrel intrauterine system (LNG-IUS) ... Full text Link to item Cite

Population-based targeted sequencing of 54 candidate genes identifies PALB2 as a susceptibility gene for high-grade serous ovarian cancer.

Journal Article J Med Genet · May 2021 PURPOSE: The known epithelial ovarian cancer (EOC) susceptibility genes account for less than 50% of the heritable risk of ovarian cancer suggesting that other susceptibility genes exist. The aim of this study was to evaluate the contribution to ovarian ca ... Full text Link to item Cite

Depot-Medroxyprogesterone Acetate Use Is Associated with Decreased Risk of Ovarian Cancer: The Mounting Evidence of a Protective Role of Progestins.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2021 BACKGROUND: Combined oral contraceptive use is associated with a decreased risk of invasive epithelial ovarian cancer (ovarian cancer). There is suggestive evidence of an inverse association between progestin-only contraceptive use and ovarian cancer risk, ... Full text Link to item Cite

Evaluating the role of alcohol consumption in breast and ovarian cancer susceptibility using population-based cohort studies and two-sample Mendelian randomization analyses.

Journal Article Int J Cancer · March 15, 2021 Alcohol consumption is correlated positively with risk for breast cancer in observational studies, but observational studies are subject to reverse causation and confounding. The association with epithelial ovarian cancer (EOC) is unclear. We performed bot ... Full text Link to item Cite

Expanding Our Understanding of Ovarian Cancer Risk: The Role of Incomplete Pregnancies.

Journal Article J Natl Cancer Inst · March 1, 2021 BACKGROUND: Parity is associated with decreased risk of invasive ovarian cancer; however, the relationship between incomplete pregnancies and invasive ovarian cancer risk is unclear. This relationship was examined using 15 case-control studies from the Ova ... Full text Link to item Cite

Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · February 2, 2021 Epithelial ovarian cancer is the leading cause of death from gynecologic cancer in the United States and is the country's fifth most common cause of cancer mortality in women. A major challenge in treating ovarian cancer is that most patients have advanced ... Full text Link to item Cite

A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization.

Journal Article Nat Commun · January 11, 2021 Previous Mendelian randomization (MR) studies on 25-hydroxyvitamin D (25(OH)D) and cancer have typically adopted a handful of variants and found no relationship between 25(OH)D and cancer; however, issues of horizontal pleiotropy cannot be reliably address ... Full text Link to item Cite

Targeting Dormant Ovarian Cancer Cells In Vitro and in an In Vivo Mouse Model of Platinum Resistance.

Journal Article Mol Cancer Ther · January 2021 Spheroids exhibit drug resistance and slow proliferation, suggesting involvement in cancer recurrence. The protein kinase C inhibitor UCN-01 (7-hydroxystaurosporine) has shown higher efficacy against slow proliferating and/or quiescent ovarian cancer cells ... Full text Link to item Cite

Cross-Cancer Genome-Wide Association Study of Endometrial Cancer and Epithelial Ovarian Cancer Identifies Genetic Risk Regions Associated with Risk of Both Cancers.

Journal Article Cancer Epidemiol Biomarkers Prev · January 2021 BACKGROUND: Accumulating evidence suggests a relationship between endometrial cancer and ovarian cancer. Independent genome-wide association studies (GWAS) for endometrial cancer and ovarian cancer have identified 16 and 27 risk regions, respectively, four ... Full text Link to item Cite

Results and Clinical Utilization of Foundation Medicine Molecular Tumor Profiling in Uterine and Ovarian Cancers.

Journal Article Target Oncol · January 2021 BACKGROUND: Recent advances in next-generation sequencing have allowed for an increase in molecular tumor profiling. OBJECTIVE: We sought to assess the actionability and clinical utilization of molecular tumor profiling results obtained via Foundation Medi ... Full text Link to item Cite

Epigenetic Regulation of Claudin-1 in the Development of Ovarian Cancer Recurrence and Drug Resistance.

Journal Article Frontiers in oncology · January 2021 Over 21,000 women are diagnosed with ovarian cancer (OC) in the United States each year and over half that number succumb to this disease annually, often due to recurrent disease. A deeper understanding of the molecular events associated with recurrent dis ... Full text Open Access Cite

Cost-effectiveness analysis comparing "PARP inhibitors-for-all" to the biomarker-directed use of PARP inhibitor maintenance therapy for newly diagnosed advanced stage ovarian cancer.

Journal Article Gynecol Oncol · November 2020 OBJECTIVES: Clinical trials evaluating universal PARP inhibitor (PARPi) frontline maintenance therapy for advanced stage ovarian cancer have reported progression-free survival (PFS) benefit. It is unclear whether PARPi maintenance therapy will universally ... Full text Link to item Cite

Offspring sex and risk of epithelial ovarian cancer: a multinational pooled analysis of 12 case-control studies.

Journal Article Eur J Epidemiol · November 2020 While childbearing protects against risk of epithelial ovarian cancer (EOC), few studies have explored the impact on maternal EOC risk of sex of offspring, which may affect the maternal environment during pregnancy. We performed a pooled analysis among par ... Full text Link to item Cite

Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE).

Journal Article Clin Cancer Res · October 15, 2020 PURPOSE: Gene expression-based molecular subtypes of high-grade serous tubo-ovarian cancer (HGSOC), demonstrated across multiple studies, may provide improved stratification for molecularly targeted trials. However, evaluation of clinical utility has been ... Full text Link to item Cite

Management of high, moderate, and low penetrance ovarian cancer susceptibility mutations: an assessment of current risk reduction practices.

Journal Article Int J Gynecol Cancer · October 2020 OBJECTIVE: Limited information exists regarding risk reduction strategies for women with moderate and low penetrance ovarian cancer susceptibility mutations. We sought to assess current risk reduction practice patterns for carriers of these mutations throu ... Full text Link to item Cite

Menopausal hormone therapy prior to the diagnosis of ovarian cancer is associated with improved survival.

Journal Article Gynecol Oncol · September 2020 PURPOSE: Prior studies of menopausal hormone therapy (MHT) and ovarian cancer survival have been limited by lack of hormone regimen detail and insufficient sample sizes. To address these limitations, a comprehensive analysis of 6419 post-menopausal women w ... Full text Link to item Cite

Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers.

Journal Article Nat Commun · July 3, 2020 Genome-wide association studies (GWAS) have led to the identification of hundreds of susceptibility loci across cancers, but the impact of further studies remains uncertain. Here we analyse summary-level data from GWAS of European ancestry across fourteen ... Full text Link to item Cite

Identification of novel epithelial ovarian cancer loci in women of African ancestry.

Journal Article Int J Cancer · June 1, 2020 Women of African ancestry have lower incidence of epithelial ovarian cancer (EOC) yet worse survival compared to women of European ancestry. We conducted a genome-wide association study in African ancestry women with 755 EOC cases, including 537 high-grade ... Full text Link to item Cite

Estrogen Plus Progestin Hormone Therapy and Ovarian Cancer: A Complicated Relationship Explored.

Journal Article Epidemiology · May 2020 BACKGROUND: Menopausal estrogen-alone therapy is a risk factor for endometrial and ovarian cancers. When a progestin is included with the estrogen daily (continuous estrogen-progestin combined therapy), there is no increased risk of endometrial cancer. How ... Full text Link to item Cite

Intraperitoneal chemotherapy following neoadjuvant chemotherapy and optimal interval tumor reductive surgery for advanced ovarian cancer.

Journal Article Gynecol Oncol · March 2020 OBJECTIVES: Intraperitoneal (IP) chemotherapy following neoadjuvant chemotherapy (NACT) and interval tumor reductive surgery (TRS) for advanced ovarian cancer is feasible, however, the impact on disease outcomes remains unclear. We compare outcomes of pati ... Full text Link to item Cite

Pan-cancer analysis of whole genomes.

Journal Article Nature · February 2020 Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1-3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matchin ... Full text Link to item Cite

The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.

Journal Article J Alzheimers Dis · 2020 BACKGROUND: Perioperative neurocognitive disorders (PND) are common complications in older adults associated with increased 1-year mortality and long-term cognitive decline. One risk factor for worsened long-term postoperative cognitive trajectory is the A ... Full text Open Access Link to item Cite

Patient preferences for attributes of primary surgical debulking versus neoadjuvant chemotherapy for treatment of newly diagnosed ovarian cancer.

Journal Article Cancer · December 15, 2019 BACKGROUND: Randomized trials have reported conflicting findings on survival for advanced-stage ovarian cancer treated with primary debulking surgery (PDS) versus neoadjuvant chemotherapy with interval debulking; surgical complications and mortality are hi ... Full text Link to item Cite

Publisher Correction: Shared heritability and functional enrichment across six solid cancers.

Journal Article Nat Commun · September 23, 2019 An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Full text Link to item Cite

NCCN Guidelines Insights: Ovarian Cancer, Version 1.2019.

Journal Article J Natl Compr Canc Netw · August 1, 2019 Epithelial ovarian cancer is the leading cause of death from gynecologic cancer in the United States, with less than half of patients living >5 years from diagnosis. A major challenge in treating ovarian cancer is that most patients have advanced disease a ... Full text Link to item Cite

Constitutively active ESR1 mutations in gynecologic malignancies and clinical response to estrogen-receptor directed therapies.

Journal Article Gynecol Oncol · July 2019 OBJECTIVE: Endocrine therapy is often considered as a treatment for hormone-responsive gynecologic malignancies. In breast cancer, activating mutations in the estrogen receptor (mutESR1) contribute to therapeutic resistance to endocrine therapy, especially ... Full text Link to item Cite

Going to extremes: determinants of extraordinary response and survival in patients with cancer.

Journal Article Nat Rev Cancer · June 2019 Research into factors affecting treatment response or survival in patients with cancer frequently involves cohorts that span the most common range of clinical outcomes, as such patients are most readily available for study. However, attention has turned to ... Full text Link to item Cite

Association between genetically predicted polycystic ovary syndrome and ovarian cancer: a Mendelian randomization study.

Journal Article Int J Epidemiol · June 1, 2019 BACKGROUND: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder with an estimated prevalence of 4-21% in reproductive aged women. Recently, the Ovarian Cancer Association Consortium (OCAC) reported a decreased risk of invasive ovarian cancer a ... Full text Link to item Cite

Management of high, moderate, and low penetrance ovarian cancer susceptibility gene mutations: An assessment of current practice patterns.

Conference Journal of Clinical Oncology · May 20, 2019 1536 Background: Limited information exists regarding appropriate risk-reduction strategies for women with moderate and low penetrance ovarian cancer (OVCA) susceptibility mutations. We sought to assess current practice patterns ... Full text Cite

Associations between lymphovascular space invasion, nodal recurrence, and survival in patients with surgical stage I endometrioid endometrial adenocarcinoma.

Journal Article World J Surg Oncol · May 10, 2019 OBJECTIVE: To investigate the predictive value of lymphovascular space invasion (LVSI) for nodal recurrence and overall survival (OS) in patients with stage I endometrioid endometrial cancer (EC) following surgical staging that included adequate lymph node ... Full text Link to item Cite

A comprehensive gene-environment interaction analysis in Ovarian Cancer using genome-wide significant common variants.

Journal Article Int J Cancer · May 1, 2019 As a follow-up to genome-wide association analysis of common variants associated with ovarian carcinoma (cancer), our study considers seven well-known ovarian cancer risk factors and their interactions with 28 genome-wide significant common genetic variant ... Full text Link to item Cite

Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women.

Journal Article Gynecol Oncol · May 2019 OBJECTIVE: Genome-wide association studies (GWASs) for epithelial ovarian cancer (EOC) have focused largely on populations of European ancestry. We aimed to identify common germline variants associated with EOC risk in Asian women. METHODS: Genotyping was ... Full text Open Access Link to item Cite

A pilot study of lower extremity lymphedema, lower extremity function, and quality of life in women after minimally invasive endometrial cancer staging surgery.

Journal Article Gynecol Oncol · May 2019 OBJECTIVE: The primary aim of this study was to pilot the use of an objective measurement technique to prospectively evaluate the incidence of lower extremity lymphedema (LEL) after minimally invasive staging surgery for endometrial cancer. Secondary objec ... Full text Link to item Cite

Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women.

Journal Article Cancer Med · May 2019 An association between genetic variants in the vitamin D receptor (VDR) gene and epithelial ovarian cancer (EOC) was previously reported in women of African ancestry (AA). We sought to examine associations between genetic variants in VDR and additional gen ... Full text Link to item Cite

The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.

Journal Article J Am Geriatr Soc · April 2019 BACKGROUND/OBJECTIVES: Every year, up to 40% of the more than 16 million older Americans who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD) or delirium. Each of these distinct syndromes is associated with decreased quality of ... Full text Open Access Link to item Cite

Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk.

Journal Article Cancer Res · February 1, 2019 DNA methylation is instrumental for gene regulation. Global changes in the epigenetic landscape have been recognized as a hallmark of cancer. However, the role of DNA methylation in epithelial ovarian cancer (EOC) remains unclear. In this study, high-densi ... Full text Link to item Cite

Functional Analysis and Fine Mapping of the 9p22.2 Ovarian Cancer Susceptibility Locus.

Journal Article Cancer Res · February 1, 2019 Genome-wide association studies have identified 40 ovarian cancer risk loci. However, the mechanisms underlying these associations remain elusive. In this study, we conducted a two-pronged approach to identify candidate causal SNPs and assess underlying bi ... Full text Link to item Cite

Shared heritability and functional enrichment across six solid cancers.

Journal Article Nat Commun · January 25, 2019 Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 con ... Full text Link to item Cite

Invasive Epithelial Ovarian Cancer Survival by Histotype and Disease Stage.

Journal Article J Natl Cancer Inst · January 1, 2019 BACKGROUND: The understanding of ovarian cancer pathogenesis has recently shifted to recognize distinct changes in how ovarian cancer histotypes are defined. Using the 2014 World Health Organization (WHO) diagnostic guidelines, we classified ovarian cancer ... Full text Link to item Cite

Role of surgery in cancer prevention

Chapter · November 16, 2018 Cite

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer.

Journal Article Cell Rep · October 30, 2018 Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehensive molecular characterization of 19 Hippo core genes in 9,125 tumor samples across 33 cancer types using multidimensional "omic" data from The Cancer Genom ... Full text Link to item Cite

A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily.

Journal Article Cell Syst · October 24, 2018 We present an integromic analysis of gene alterations that modulate transforming growth factor β (TGF-β)-Smad-mediated signaling in 9,125 tumor samples across 33 cancer types in The Cancer Genome Atlas (TCGA). Focusing on genes that encode mediators and re ... Full text Link to item Cite

Association of p16 expression with prognosis varies across ovarian carcinoma histotypes: an Ovarian Tumor Tissue Analysis consortium study.

Journal Article J Pathol Clin Res · October 2018 We aimed to validate the prognostic association of p16 expression in ovarian high-grade serous carcinomas (HGSC) and to explore it in other ovarian carcinoma histotypes. p16 protein expression was assessed by clinical-grade immunohistochemistry in 6525 ova ... Full text Link to item Cite

Histotype classification of ovarian carcinoma: A comparison of approaches.

Journal Article Gynecol Oncol · October 2018 OBJECTIVE: Major changes in the classification of ovarian carcinoma histotypes occurred over the last two decades, resulting in the current 2014 World Health Organization (WHO) diagnostic criteria that recognize five principal histotypes: high-grade serous ... Full text Link to item Cite

A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk.

Journal Article Cancer Res · September 15, 2018 Large-scale genome-wide association studies (GWAS) have identified approximately 35 loci associated with epithelial ovarian cancer (EOC) risk. The majority of GWAS-identified disease susceptibility variants are located in noncoding regions, and causal gene ... Full text Link to item Cite

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients.

Journal Article Cancer Cell · August 13, 2018 Our comprehensive analysis of alternative splicing across 32 The Cancer Genome Atlas cancer types from 8,705 patients detects alternative splicing events and tumor variants by reanalyzing RNA and whole-exome sequencing data. Tumors have up to 30% more alte ... Full text Link to item Cite

Prospective Evaluation of Lymph Node Processing at Staging Surgery for High-grade Endometrial Cancer.

Journal Article Int J Gynecol Pathol · May 2018 To determine whether the processing of additional adipose tissue collected during lymph node (LN) dissection results in the identification of additional LNs during endometrial cancer (EC) staging and to determine if the division of LNs into nodal basin-spe ... Full text Link to item Cite

The Immune Landscape of Cancer.

Journal Article Immunity · April 17, 2018 We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified six immune subtypes-wound healing, IFN-γ dominant, inflammatory, lymphocyt ... Full text Link to item Cite

Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas.

Journal Article Cancer Cell · April 9, 2018 We analyzed 921 adenocarcinomas of the esophagus, stomach, colon, and rectum to examine shared and distinguishing molecular characteristics of gastrointestinal tract adenocarcinomas (GIACs). Hypermutated tumors were distinct regardless of cancer type and c ... Full text Link to item Cite

lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer.

Journal Article Cancer Cell · April 9, 2018 We characterized the epigenetic landscape of genes encoding long noncoding RNAs (lncRNAs) across 6,475 tumors and 455 cancer cell lines. In stark contrast to the CpG island hypermethylation phenotype in cancer, we observed a recurrent hypomethylation of 1, ... Full text Link to item Cite

Genomic and Functional Approaches to Understanding Cancer Aneuploidy.

Journal Article Cancer Cell · April 9, 2018 Aneuploidy, whole chromosome or chromosome arm imbalance, is a near-universal characteristic of human cancers. In 10,522 cancer genomes from The Cancer Genome Atlas, aneuploidy was correlated with TP53 mutation, somatic mutation rate, and expression of pro ... Full text Link to item Cite

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers.

Journal Article Cancer Cell · April 9, 2018 We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of four gynecological types plus breast. Our aims were to identify shared and unique molecular features, clinically significant subtypes, and potential therapeutic targets. We f ... Full text Link to item Cite

Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.

Journal Article Cell · April 5, 2018 The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of diverse genomic alterations underlying human cancers. At this historic junction marking the completion of genomic characterization of over 11,000 tumors from 33 cancer types, we pr ... Full text Link to item Cite

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.

Journal Article Cell · April 5, 2018 We conducted comprehensive integrative molecular analyses of the complete set of tumors in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and representing 33 types of cancer. We performed molecular clustering using data on chr ... Full text Link to item Cite

Pathogenic Germline Variants in 10,389 Adult Cancers.

Journal Article Cell · April 5, 2018 We conducted the largest investigation of predisposition variants in cancer to date, discovering 853 pathogenic or likely pathogenic variants in 8% of 10,389 cases from 33 cancer types. Twenty-one genes showed single or cross-cancer associations, including ... Full text Link to item Cite

A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples.

Journal Article Cell · April 5, 2018 The role of enhancers, a key class of non-coding regulatory DNA elements, in cancer development has increasingly been appreciated. Here, we present the detection and characterization of a large number of expressed enhancers in a genome-wide analysis of 892 ... Full text Link to item Cite

Oncogenic Signaling Pathways in The Cancer Genome Atlas.

Journal Article Cell · April 5, 2018 Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tu ... Full text Link to item Cite

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation.

Journal Article Cell · April 5, 2018 Cancer progression involves the gradual loss of a differentiated phenotype and acquisition of progenitor and stem-cell-like features. Here, we provide novel stemness indices for assessing the degree of oncogenic dedifferentiation. We used an innovative one ... Full text Link to item Cite

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics.

Journal Article Cell · April 5, 2018 For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features represe ... Full text Link to item Cite

Comprehensive Characterization of Cancer Driver Genes and Mutations.

Journal Article Cell · April 5, 2018 Identifying molecular cancer drivers is critical for precision oncology. Multiple advanced algorithms to identify drivers now exist, but systematic attempts to combine and optimize them on large datasets are few. We report a PanCancer and PanSoftware analy ... Full text Link to item Cite

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma.

Journal Article Cell Rep · April 3, 2018 Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, includ ... Full text Link to item Cite

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context.

Journal Article Cell Rep · April 3, 2018 Long noncoding RNAs (lncRNAs) are commonly dysregulated in tumors, but only a handful are known to play pathophysiological roles in cancer. We inferred lncRNAs that dysregulate cancer pathways, oncogenes, and tumor suppressors (cancer genes) by modeling th ... Full text Link to item Cite

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.

Journal Article Cell Rep · April 3, 2018 Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% validation ra ... Full text Link to item Cite

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images.

Journal Article Cell Rep · April 3, 2018 Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumor-infiltrating lymphocytes (TILs) based on H&E images from 13 TCGA t ... Full text Link to item Cite

Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers.

Journal Article Cell Rep · April 3, 2018 Metabolic reprogramming provides critical information for clinical oncology. Using molecular data of 9,125 patient samples from The Cancer Genome Atlas, we identified tumor subtypes in 33 cancer types based on mRNA expression patterns of seven major metabo ... Full text Link to item Cite

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas.

Journal Article Cell Rep · April 3, 2018 This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smoking and/or human papillomavirus (HPV). SCCs harbor 3q, 5p, and other recu ... Full text Link to item Cite

Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types.

Journal Article Cell Rep · April 3, 2018 Protein ubiquitination is a dynamic and reversible process of adding single ubiquitin molecules or various ubiquitin chains to target proteins. Here, using multidimensional omic data of 9,125 tumor samples across 33 cancer types from The Cancer Genome Atla ... Full text Link to item Cite

Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas.

Journal Article Cell Rep · April 3, 2018 Precision oncology uses genomic evidence to match patients with treatment but often fails to identify all patients who may respond. The transcriptome of these "hidden responders" may reveal responsive molecular states. We describe and evaluate a machine-le ... Full text Link to item Cite

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types.

Journal Article Cell Rep · April 3, 2018 Hotspot mutations in splicing factor genes have been recently reported at high frequency in hematological malignancies, suggesting the importance of RNA splicing in cancer. We analyzed whole-exome sequencing data across 33 tumor types in The Cancer Genome ... Full text Link to item Cite

Systematic Analysis of Splice-Site-Creating Mutations in Cancer.

Journal Article Cell Rep · April 3, 2018 For the past decade, cancer genomic studies have focused on mutations leading to splice-site disruption, overlooking those having splice-creating potential. Here, we applied a bioinformatic tool, MiSplice, for the large-scale discovery of splice-site-creat ... Full text Link to item Cite

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas.

Journal Article Cell Rep · April 3, 2018 DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types. Mutations with accompanying loss of heter ... Full text Link to item Cite

Common Genetic Variation and Susceptibility to Ovarian Cancer: Current Insights and Future Directions.

Journal Article Cancer Epidemiol Biomarkers Prev · April 2018 In this review, we summarize current progress in the genetic epidemiology of epithelial ovarian cancer (EOC), focusing exclusively on elucidating the role of common germline genetic variation in conferring susceptibility to EOC. We provide an overview of t ... Full text Link to item Cite

Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies.

Journal Article Int J Epidemiol · April 1, 2018 BACKGROUND: Ovarian cancer incidence differs substantially by race/ethnicity, but the reasons for this are not well understood. Data were pooled from the African American Cancer Epidemiology Study (AACES) and 11 case-control studies in the Ovarian Cancer A ... Full text Link to item Cite

Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study.

Journal Article Br J Cancer · April 2018 BACKGROUND: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bia ... Full text Link to item Cite

Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study.

Journal Article Int J Epidemiol · April 1, 2018 BACKGROUND: Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations ar ... Full text Link to item Cite

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas.

Journal Article Cell Syst · March 28, 2018 Although the MYC oncogene has been implicated in cancer, a systematic assessment of alterations of MYC, related transcription factors, and co-regulatory proteins, forming the proximal MYC network (PMN), across human cancers is lacking. Using computational ... Full text Link to item Cite

Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines.

Journal Article Cell Syst · March 28, 2018 The Cancer Genome Atlas (TCGA) cancer genomics dataset includes over 10,000 tumor-normal exome pairs across 33 different cancer types, in total >400 TB of raw data files requiring analysis. Here we describe the Multi-Center Mutation Calling in Multiple Can ... Full text Link to item Cite

Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence.

Journal Article Am J Epidemiol · February 1, 2018 There have been recent proposals advocating the use of additive gene-environment interaction instead of the widely used multiplicative scale, as a more relevant public health measure. Using gene-environment independence enhances statistical power for testi ... Full text Link to item Cite

Menstrual pain and risk of epithelial ovarian cancer: Results from the Ovarian Cancer Association Consortium.

Journal Article International journal of cancer · February 2018 Menstrual pain, a common gynecological condition, has been associated with increased risk of ovarian cancer in some, but not all studies. Furthermore, potential variations in the association between menstrual pain and ovarian cancer by histologic subtype h ... Full text Cite

Polycystic Ovary Syndrome, Oligomenorrhea, and Risk of Ovarian Cancer Histotypes: Evidence from the Ovarian Cancer Association Consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · February 2018 Background: Polycystic ovary syndrome (PCOS), and one of its distinguishing characteristics, oligomenorrhea, have both been associated with ovarian cancer risk in some but not all studies. However, these associations have been rarely examined by ovarian ca ... Full text Link to item Cite

Estimating Cost-effectiveness of a Multimodal Ovarian Cancer Screening Program in the United States: Secondary Analysis of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS).

Journal Article JAMA Oncol · February 1, 2018 IMPORTANCE: The United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) is the largest randomized clinical trial to evaluate screening's impact on ovarian cancer mortality, assigning women to multimodal screening (MMS) with serum cancer an ... Full text Link to item Cite

Urinary diversion in the genitourinary cancer survivor.

Journal Article Gynecol Oncol · February 2018 Urinary diversion has been in the scope of practice of Gynecologic Oncologists since the inception of the sub-specialty. However, many fewer urinary diversions are performed currently than in the past due to improved prevention of cervical cancer. The inte ... Full text Link to item Cite

Ovarian cancer risk, ALDH2 polymorphism and alcohol drinking: Asian data from the Ovarian Cancer Association Consortium.

Journal Article Cancer Sci · February 2018 The aldehyde dehydrogenase 2 (ALDH2) polymorphism rs671 (Glu504Lys) causes ALDH2 inactivation and adverse acetaldehyde exposure among Asians, but little is known of the association between alcohol consumption and rs671 and ovarian cancer (OvCa) in Asians. ... Full text Link to item Cite

Genome-wide association study evaluating single-nucleotide polymorphisms and outcomes in patients with advanced stage serous ovarian or primary peritoneal cancer: An NRG Oncology/Gynecologic Oncology Group study.

Journal Article Gynecol Oncol · November 2017 OBJECTIVE: This study evaluated single nucleotide polymorphisms (SNPs) associated with progression free (PFS) and overall survival (OS) in patients with advanced stage serous EOC. METHODS: Patients enrolled in GOG-172 and 182 who provided specimens for tra ... Full text Link to item Cite

Race-specific molecular alterations correlate with differential outcomes for black and white endometrioid endometrial cancer patients.

Journal Article Cancer · October 15, 2017 BACKGROUND: The objective of this study was to identify molecular alterations associated with disease outcomes for white and black patients with endometrioid endometrial cancer (EEC). METHODS: EEC samples from black (n = 17) and white patients (n = 13) wer ... Full text Link to item Cite

Analyses of germline variants associated with ovarian cancer survival identify functional candidates at the 1q22 and 19p12 outcome loci.

Journal Article Oncotarget · September 12, 2017 We previously identified associations with ovarian cancer outcome at five genetic loci. To identify putatively causal genetic variants and target genes, we prioritized two ovarian outcome loci (1q22 and 19p12) for further study. Bioinformatic and functiona ... Full text Link to item Cite

Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors.

Journal Article Nature medicine · September 2017 It is generally assumed that recurrent mutations within a given cancer driver gene elicit similar drug responses. Cancer genome studies have identified recurrent but divergent missense mutations affecting the substrate-recognition domain of the ubiquitin l ... Full text Cite

Early Detection of Ovarian Cancer using the Risk of Ovarian Cancer Algorithm with Frequent CA125 Testing in Women at Increased Familial Risk - Combined Results from Two Screening Trials.

Journal Article Clin Cancer Res · July 15, 2017 Purpose: Women at familial/genetic ovarian cancer risk often undergo screening despite unproven efficacy. Research suggests each woman has her own CA125 baseline; significant increases above this level may identify cancers earlier than standard 6- to 12-mo ... Full text Link to item Cite

The hereditary nature of small cell carcinoma of the ovary, hypercalcemic type: two new familial cases.

Journal Article Fam Cancer · July 2017 Small cell carcinoma of the ovary, hypercalcemic type, (SCCOHT) is the most common undifferentiated ovarian cancer in women aged under 40 years. SCCOHT is a monogenic disease, characterized by germline and somatic SMARCA4 mutations. Recent studies have str ... Full text Link to item Cite

Abstract 1289: Evaluation of vitamin D receptor regulated genes reveals EGFR polymorphism is associated with high-grade serous ovarian cancer in African American women

Conference Cancer Research · July 1, 2017 AbstractFew studies have evaluated genetic risk factors for ovarian cancer in African American women. In a previous study with small sample sizes, Vitamin D Receptor (VDR) variants were shown to increase ris ... Full text Cite

Abstract 1991: Enhanced role of the extracellular matrix in ovarian cancer recurrence

Conference Cancer Research · July 1, 2017 AbstractPurpose: Despite improvements in care and advancements in the understanding of ovarian cancer (OC) pathobiology and genetic alterations, the survival rate is disappointingly low when compared to that ... Full text Cite

Analyses of germline variants associated with ovarian cancer survival identify functional candidates at the 1q22 and 19p12 outcome loci.

Journal Article Oncotarget · June 15, 2017 We previously identified associations with ovarian cancer outcome at five genetic loci. To identify putatively causal genetic variants and target genes, we prioritized two ovarian outcome loci (1q22 and 19p12) for further study. Bioinformatic and functiona ... Full text Link to item Cite

Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies.

Journal Article Int J Cancer · June 1, 2017 Cigarette smoking is associated with an increased risk of developing mucinous ovarian tumors but whether it is associated with ovarian cancer survival overall or for the different histotypes is unestablished. Furthermore, it is unknown whether the associat ... Full text Link to item Cite

Cost-effectiveness of ovarian cancer screening: An analysis of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) from a U.S. health system perspective.

Conference Journal of Clinical Oncology · May 20, 2017 6608 Background: UKCTOCS is the largest randomized controlled trial to evaluate screening’s impact on ovarian cancer mortality, assigning women to multimodal screening (MMS) with serum CA125 interpreted with a risk algorithm; ann ... Full text Cite

Evaluating the repertoire of immune checkpoint markers expressed on peripheral and ascites CD8+ T cells in ovarian cancer.

Conference Journal of Clinical Oncology · May 20, 2017 5571 Background: Understanding the immune checkpoint marker repertoire can facilitate development of therapeutic strategies to improve efficacy of immune-based therapies. We used a novel high-dimensional flow cytometry panel to d ... Full text Cite

History of hypertension, heart disease, and diabetes and ovarian cancer patient survival: evidence from the ovarian cancer association consortium.

Journal Article Cancer Causes Control · May 2017 PURPOSE: Survival following ovarian cancer diagnosis is generally low; understanding factors related to prognosis could be important to optimize treatment. The role of previously diagnosed comorbidities and use of medications for those conditions in relati ... Full text Link to item Cite

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.

Journal Article Nat Genet · May 2017 To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for d ... Full text Link to item Cite

Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium.

Journal Article Br J Cancer · April 25, 2017 BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with improved survival in some cancers, but evidence for ovarian cancer is limited. METHODS: Pooling individual-level data from 12 Ovarian Cancer Association Consortium studies, ... Full text Link to item Cite

Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer.

Journal Article BMC Genomics · March 31, 2017 BACKGROUND: Epigenetic information can be used to identify clinically relevant genomic variants single nucleotide polymorphisms (SNPs) of functional importance in cancer development. Super-enhancers are cell-specific DNA elements, acting to determine tissu ... Full text Link to item Cite

No Evidence That Genetic Variation in the Myeloid-Derived Suppressor Cell Pathway Influences Ovarian Cancer Survival.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2017 Background: The precise mechanism by which the immune system is adversely affected in cancer patients remains poorly understood, but the accumulation of immunosuppressive/protumorigenic myeloid-derived suppressor cells (MDSCs) is thought to be a prominent ... Full text Link to item Cite

Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci.

Journal Article Br J Cancer · February 14, 2017 BACKGROUND: Genome-wide association studies (GWAS) have identified 18 loci associated with serous ovarian cancer (SOC) susceptibility but the biological mechanisms driving these findings remain poorly characterised. Germline cancer risk loci may be enriche ... Full text Link to item Cite

The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers.

Journal Article Cancer Epidemiol Biomarkers Prev · January 2017 BACKGROUND: Common cancers develop through a multistep process often including inherited susceptibility. Collaboration among multiple institutions, and funding from multiple sources, has allowed the development of an inexpensive genotyping microarray, the ... Full text Link to item Cite

Pelvic Inflammatory Disease and the Risk of Ovarian Cancer and Borderline Ovarian Tumors: A Pooled Analysis of 13 Case-Control Studies.

Journal Article Am J Epidemiol · January 1, 2017 Inflammation has been implicated in ovarian carcinogenesis. However, studies investigating the association between pelvic inflammatory disease (PID) and ovarian cancer risk are few and inconsistent. We investigated the association between PID and the risk ... Full text Link to item Cite

Integration of Population-Level Genotype Data with Functional Annotation Reveals Over-Representation of Long Noncoding RNAs at Ovarian Cancer Susceptibility Loci.

Journal Article Cancer Epidemiol Biomarkers Prev · January 2017 BACKGROUND: Genome-wide association studies (GWAS) have identified multiple loci associated with epithelial ovarian cancer (EOC) susceptibility, but further progress requires integration of epidemiology and biology to illuminate true risk loci below genome ... Full text Link to item Cite

A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer.

Journal Article Int J Cancer · December 15, 2016 Menopausal estrogen-alone therapy (ET) is a well-established risk factor for serous and endometrioid ovarian cancer. Genetics also plays a role in ovarian cancer, which is partly attributable to 18 confirmed ovarian cancer susceptibility loci identified by ... Full text Link to item Cite

Telomere structure and maintenance gene variants and risk of five cancer types.

Journal Article Int J Cancer · December 15, 2016 Telomeres cap chromosome ends, protecting them from degradation, double-strand breaks, and end-to-end fusions. Telomeres are maintained by telomerase, a reverse transcriptase encoded by TERT, and an RNA template encoded by TERC. Loci in the TERT and adjoin ... Full text Link to item Cite

PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.

Journal Article J Med Genet · December 2016 BACKGROUND: The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some of these mutations are associated with breast cancer risk ... Full text Link to item Cite

Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility: results from a large-scale collaboration.

Journal Article Oncotarget · November 8, 2016 RNA editing in mammals is a form of post-transcriptional modification in which adenosine is converted to inosine by the adenosine deaminases acting on RNA (ADAR) family of enzymes. Based on evidence of altered ADAR expression in epithelial ovarian cancers ... Full text Link to item Cite

Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.

Journal Article Oncotarget · October 25, 2016 BACKGROUND: Regulatory T (Treg) cells, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and, thus, variants in genes encoding Treg cell immune molecules could be associated with ovarian cancer. METHODS: In a population of 15,59 ... Full text Link to item Cite

Risk Prediction for Epithelial Ovarian Cancer in 11 United States-Based Case-Control Studies: Incorporation of Epidemiologic Risk Factors and 17 Confirmed Genetic Loci.

Journal Article Am J Epidemiol · October 15, 2016 Previously developed models for predicting absolute risk of invasive epithelial ovarian cancer have included a limited number of risk factors and have had low discriminatory power (area under the receiver operating characteristic curve (AUC) < 0.60). Becau ... Full text Open Access Link to item Cite

Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study.

Journal Article Int J Epidemiol · October 2016 BACKGROUND: In vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention. However, the relationship between vitamin D and ovarian cancer is uncertain, with observational studies generating conflicting findi ... Full text Link to item Cite

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.

Journal Article Nat Commun · September 7, 2016 A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associat ... Full text Link to item Cite

Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types.

Journal Article Cancer Discov · September 2016 UNLABELLED: Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis dat ... Full text Link to item Cite

Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk.

Journal Article Hum Mol Genet · August 15, 2016 Rare and low frequency variants are not well covered in most germline genotyping arrays and are understudied in relation to epithelial ovarian cancer (EOC) risk. To address this gap, we used genotyping arrays targeting rarer protein-coding variation in 8,1 ... Full text Link to item Cite

Performance of sentinel lymph node biopsy in high-risk endometrial cancer.

Journal Article Gynecol Oncol Rep · August 2016 OBJECTIVE: To determine the rate and performance of sentinel lymph node (SLN) mapping among women with high-risk endometrial cancers. METHODS: Patients diagnosed between 2012 and 2015 with uterine cancer of grade 3 endometrioid, clear cell, serous or carci ... Full text Link to item Cite

Association between menopausal estrogen-only therapy and ovarian carcinoma risk

Journal Article Obstetrical and Gynecological Survey · August 1, 2016 Full text Cite

Abstract 3407: Gene expression subtypes of high grade serous ovarian cancer in African American women

Conference Cancer Research · July 15, 2016 AbstractOvarian cancer accounts for 5% of cancer deaths and is the fifth leading cause of cancer death in women in the United States. While incidence is higher in European American (EA) than African American ... Full text Cite

Abstract 797: A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer

Conference Cancer Research · July 15, 2016 AbstractMenopausal estrogen-alone therapy (ET) is a well-established risk factor for serous and endometrioid ovarian carcinoma. Genetics also plays an important role in ovarian carcinoma etiology, which is p ... Full text Cite

Assessing the genetic architecture of epithelial ovarian cancer histological subtypes.

Journal Article Hum Genet · July 2016 Epithelial ovarian cancer (EOC) is one of the deadliest common cancers. The five most common types of disease are high-grade and low-grade serous, endometrioid, mucinous and clear cell carcinoma. Each of these subtypes present distinct molecular pathogenes ... Full text Link to item Cite

Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · July 2016 BACKGROUND: Despite a large body of literature evaluating the association between recreational physical activity and epithelial ovarian cancer (EOC) risk, the extant evidence is inconclusive, and little is known about the independent association between re ... Full text Link to item Cite

Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium.

Journal Article Br J Cancer · June 28, 2016 BACKGROUND: Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between ... Full text Link to item Cite

The Association Between Body Mass Index and Presenting Symptoms in African American Women with Ovarian Cancer.

Journal Article J Womens Health (Larchmt) · June 2016 BACKGROUND: Ovarian cancer, the most lethal gynecologic malignancy, typically comes to clinical attention due to nonspecific gastrointestinal or pelvic symptoms. African Americans with ovarian cancer have a greater mortality burden than whites and are also ... Full text Link to item Cite

The influence of clinical and genetic factors on patient outcome in small cell carcinoma of the ovary, hypercalcemic type.

Journal Article Gynecol Oncol · June 2016 OBJECTIVE: Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is an aggressive tumor, with long term survival at ~30% in early stage disease. SCCOHT is caused by germline and somatic SMARCA4 mutations, but the effect of the mutation type on pat ... Full text Link to item Cite

Adult body mass index and risk of ovarian cancer by subtype: a Mendelian randomization study.

Journal Article Int J Epidemiol · June 2016 BACKGROUND: Observational studies have reported a positive association between body mass index (BMI) and ovarian cancer risk. However, questions remain as to whether this represents a causal effect, or holds for all histological subtypes. The lack of assoc ... Full text Link to item Cite

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.

Journal Article Gynecol Oncol · May 2016 OBJECTIVE: Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3' UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. ... Full text Link to item Cite

Assessment of Multifactor Gene-Environment Interactions and Ovarian Cancer Risk: Candidate Genes, Obesity, and Hormone-Related Risk Factors.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2016 BACKGROUND: Many epithelial ovarian cancer (EOC) risk factors relate to hormone exposure and elevated estrogen levels are associated with obesity in postmenopausal women. Therefore, we hypothesized that gene-environment interactions related to hormone-rela ... Full text Link to item Cite

Association Between Menopausal Estrogen-Only Therapy and Ovarian Carcinoma Risk.

Journal Article Obstet Gynecol · May 2016 OBJECTIVE: To describe the association between postmenopausal estrogen-only therapy use and risk of ovarian carcinoma, specifically with regard to disease histotype and duration and timing of use. METHODS: We conducted a pooled analysis of 906 women with o ... Full text Link to item Cite

The association between socioeconomic status and tumour stage at diagnosis of ovarian cancer: A pooled analysis of 18 case-control studies.

Journal Article Cancer Epidemiol · April 2016 PURPOSE: Socioeconomic status (SES) is a known predictor of survival for several cancers and it has been suggested that SES differences affecting tumour stage at diagnosis may be the most important explanatory factor for this. However, only a limited numbe ... Full text Link to item Cite

Subthreshold posttraumatic stress disorder: A meta-analytic review of DSM-IV prevalence and a proposed DSM-5 approach to measurement.

Journal Article Psychol Trauma · March 2016 Subthreshold posttraumatic stress disorder (PTSD) is a chronic condition that is often ignored, the cumulative effects of which can negatively impact an individual's quality of life and overall health care costs. However, subthreshold PTSD prevalence rates ... Full text Link to item Cite

Investigation of Exomic Variants Associated with Overall Survival in Ovarian Cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2016 BACKGROUND: While numerous susceptibility loci for epithelial ovarian cancer (EOC) have been identified, few associations have been reported with overall survival. In the absence of common prognostic genetic markers, we hypothesize that rare coding variant ... Full text Link to item Cite

A targeted genetic association study of epithelial ovarian cancer susceptibility.

Journal Article Oncotarget · February 16, 2016 BACKGROUND: Genome-wide association studies have identified several common susceptibility alleles for epithelial ovarian cancer (EOC). To further understand EOC susceptibility, we examined previously ungenotyped candidate variants, including uncommon varia ... Full text Link to item Cite

Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer.

Journal Article Oncotarget · February 9, 2016 Women with epithelial ovarian cancer (EOC) are usually treated with platinum/taxane therapy after cytoreductive surgery but there is considerable inter-individual variation in response. To identify germline single-nucleotide polymorphisms (SNPs) that contr ... Full text Link to item Cite

BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers.

Other J Natl Cancer Inst · February 2016 BACKGROUND: The K3326X variant in BRCA2 (BRCA2*c.9976A>T; p.Lys3326*; rs11571833) has been found to be associated with small increased risks of breast cancer. However, it is not clear to what extent linkage disequilibrium with fully pathogenic mutations mi ... Full text Link to item Cite

Abstract B27: Investigation of small GTPase genes in epithelial ovarian cancer.

Journal Article Clinical Cancer Research · January 15, 2016 AbstractBackground: Epithelial Ovarian Cancer (EOC) is a lethal gynecologic malignancy and the fifth cause of cancer mortality in women in the US. Normal ovarian physiology is intricately connected to tightl ... Full text Cite

Evidence of a genetic link between endometriosis and ovarian cancer.

Journal Article Fertil Steril · January 2016 OBJECTIVE: To evaluate whether endometriosis-associated genetic variation affects risk of ovarian cancer. DESIGN: Pooled genetic analysis. SETTING: University hospital. PATIENT(S): Genetic data from 46,176 participants (15,361 ovarian cancer cases and 30,8 ... Full text Link to item Cite

Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium.

Journal Article Clin Cancer Res · December 1, 2015 PURPOSE: Chemotherapy resistance remains a major challenge in the treatment of ovarian cancer. We hypothesize that germline polymorphisms might be associated with clinical outcome. EXPERIMENTAL DESIGN: We analyzed approximately 2.8 million genotyped and im ... Full text Link to item Cite

Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk.

Journal Article Genet Epidemiol · December 2015 Epithelial-mesenchymal transition (EMT) is a process whereby epithelial cells assume mesenchymal characteristics to facilitate cancer metastasis. However, EMT also contributes to the initiation and development of primary tumors. Prior studies that explored ... Full text Link to item Cite

Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer.

Journal Article Carcinogenesis · November 2015 Genome-wide association studies have identified 20 genomic regions associated with risk of epithelial ovarian cancer (EOC), but many additional risk variants may exist. Here, we evaluated associations between common genetic variants [single nucleotide poly ... Full text Link to item Cite

A functional variant in HOXA11-AS, a novel long non-coding RNA, inhibits the oncogenic phenotype of epithelial ovarian cancer.

Journal Article Oncotarget · October 27, 2015 The homeobox A (HOXA) region of protein-coding genes impacts female reproductive system embryogenesis and ovarian carcinogenesis. The 5-prime end of HOXA includes three long non-coding RNAs (lncRNAs) (HOXA10-AS, HOXA11-AS, and HOTTIP) that are underexplore ... Full text Link to item Cite

Shared genetics underlying epidemiological association between endometriosis and ovarian cancer.

Journal Article Hum Mol Genet · October 15, 2015 Epidemiological studies have demonstrated associations between endometriosis and certain histotypes of ovarian cancer, including clear cell, low-grade serous and endometrioid carcinomas. We aimed to determine whether the observed associations might be due ... Full text Link to item Cite

Prognostic significance of differential expression of angiogenic genes in women with high-grade serous ovarian carcinoma.

Journal Article Gynecol Oncol · October 2015 OBJECTIVES: To identify angiogenic biomarkers associated with tumor angiogenesis and clinical outcome in high-grade serous ovarian cancer (HGSC). METHODS: 51 HGSC samples were analyzed using Affymetrix HG-U133A microarray. Microvessel density (MVD) counts ... Full text Link to item Cite

Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk.

Journal Article Cancer Epidemiol Biomarkers Prev · October 2015 BACKGROUND: Genome-wide association studies (GWAS) have so far reported 12 loci associated with serous epithelial ovarian cancer (EOC) risk. We hypothesized that some of these loci function through nearby transcription factor (TF) genes and that putative t ... Full text Link to item Cite

Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer.

Journal Article Nat Commun · September 22, 2015 Genome-wide association studies have reported 11 regions conferring risk of high-grade serous epithelial ovarian cancer (HGSOC). Expression quantitative trait locus (eQTL) analyses can identify candidate susceptibility genes at risk loci. Here we evaluate ... Full text Link to item Cite

Abstract POSTER-THER-1420: Ascites drives ovarian cancer stem-like cell growth: therapeutic opportunities

Conference Clinical Cancer Research · August 15, 2015 AbstractBackground: A significant literature suggests that cancer stem-like cells drive the aggressive behavior of ovarian cancer. Cancer stem-like cells are distinct from bulk tumor cells in possessing self ... Full text Cite

Abstract POSTER-BIOL-1319: Temporal shifts in the epigenetic regulation of tight junctions from primary to recurrent ovarian cancer

Conference Clinical Cancer Research · August 15, 2015 AbstractPurpose: Despite a complete clinical response following treatment with surgery and first-line chemotherapy, about 70-90% of patients with advanced stage ovarian cancer (OC) will inevitably experience ... Full text Cite

Genome-wide significant risk associations for mucinous ovarian carcinoma.

Journal Article Nat Genet · August 2015 Genome-wide association studies have identified several risk associations for ovarian carcinomas but not for mucinous ovarian carcinomas (MOCs). Our analysis of 1,644 MOC cases and 21,693 controls with imputation identified 3 new risk associations: rs75259 ... Full text Link to item Cite

Abstract 2236: Emergence of epigenetic regulation of tight junction genes in recurrent serous epithelial ovarian cancer

Conference Cancer Research · August 1, 2015 AbstractPurpose: Despite a complete clinical response following treatment with surgery and first-line chemotherapy, about 70-90% of advanced ovarian cancer (OC) patients experience cancer recurrence. Our obj ... Full text Cite

Abstract 4635: Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility

Conference Cancer Research · August 1, 2015 AbstractBackground: Recent bioinformatic analyses and high-throughput sequencing efforts have revealed that RNA editing is a widespread post-transcriptional modification that affects non-coding repetitive el ... Full text Cite

Abstract 4633: Evidence that long non-coding RNA variants associate with epithelial ovarian cancer risk

Conference Cancer Research · August 1, 2015 AbstractBackground: Genome wide association studies (GWAS) have identified 20 loci associated with epithelial ovarian cancer (EOC) risk. Additional EOC risk loci await identification, and biological approach ... Full text Cite

Abstract 4634: Variants within super-enhancer regulatory elements associate with epithelial ovarian cancer risk

Conference Cancer Research · August 1, 2015 AbstractBackground: Cell-type-specific super enhancers, or large clusters of mediator-rich enhancers, are highly transcribed regions of the genome with key functions in the maintenance of cell identity and c ... Full text Cite

Abstract 4636: Investigation of exome variants associated with overall survival in ovarian cancer

Conference Cancer Research · August 1, 2015 AbstractMany germline genetic variants have been found to be associated with susceptibility to epithelial ovarian cancer (EOC), but currently few associations have been identified for EOC outcomes such as ov ... Full text Cite

Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci.

Journal Article Hum Mol Genet · July 1, 2015 Understanding the regulatory landscape of the human genome is a central question in complex trait genetics. Most single-nucleotide polymorphisms (SNPs) associated with cancer risk lie in non-protein-coding regions, implicating regulatory DNA elements as fu ... Full text Link to item Cite

Population distribution of lifetime risk of ovarian cancer in the United States.

Journal Article Cancer Epidemiol Biomarkers Prev · April 2015 BACKGROUND: In U.S. women, lifetime risk of ovarian cancer is 1.37%, but some women are at a substantially lower or higher risk than this average. METHODS: We have characterized the distribution of lifetime risk in the general population. Published data on ... Full text Link to item Cite

Prophylactic oophorectomy for hereditary small cell carcinoma of the ovary, hypercalcemic type.

Journal Article Gynecol Oncol Rep · April 2015 •Prophylactic oophorectomy can prevent small cell carcinoma of the ovary, hypercalcemic type in carriers of germline SMARCA4 mutations.•Unaffected SMARCA4 mutation carriers who desire children may be best served by oocyte cryopreservation prior to prophyla ... Full text Link to item Cite

Evaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study.

Journal Article Gynecol Oncol · March 2015 OBJECTIVE: Ovarian cancer is a hormone-related disease with a strong genetic basis. However, none of its high-penetrance susceptibility genes and GWAS-identified variants to date are known to be involved in hormonal pathways. Given the hypothesized etiolog ... Full text Link to item Cite

Syngeneic Murine Ovarian Cancer Model Reveals That Ascites Enriches for Ovarian Cancer Stem-Like Cells Expressing Membrane GRP78.

Journal Article Mol Cancer Ther · March 2015 Patients with ovarian cancer are generally diagnosed at FIGO (International Federation of Gynecology and Obstetrics) stage III/IV, when ascites is common. The volume of ascites correlates positively with the extent of metastasis and negatively with prognos ... Full text Link to item Cite

Vaginal cuff thermal injury by mode of colpotomy at total laparoscopic hysterectomy: a randomized clinical trial.

Conference J Minim Invasive Gynecol · February 2015 STUDY OBJECTIVE: To evaluate if the use of Valleylab mode ("V mode") (Covidien, Mansfield, MA) electrothermal energy for colpotomy during total laparoscopic hysterectomy (LH) results in a smaller margin of thermal injury to the upper vagina compared with t ... Full text Link to item Cite

MicroRNAs in endometrial cancers from black and white patients.

Journal Article Am J Obstet Gynecol · February 2015 OBJECTIVE: Previous studies have identified differences in gene mutations among endometrial cancers from whites and blacks suggesting that differences in tumor biology may explain racial disparities in patient outcome. Micro RNAs (miRNAs) have emerged as r ... Full text Link to item Cite

Identification of six new susceptibility loci for invasive epithelial ovarian cancer.

Journal Article Nat Genet · February 2015 Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and BRCA2 mutation carriers who are at high risk of EOC. After imputation to 1 ... Full text Link to item Cite

Role of surgery in cancer prevention

Chapter · January 7, 2015 Cite

Role of surgery in cancer prevention

Chapter · January 7, 2015 Cite

Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk.

Journal Article PLoS One · 2015 BACKGROUND: Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which in turn may promote the formation of reactive oxygen species, promoting DNA damage and aberrant ex ... Full text Link to item Cite

Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC).

Journal Article J Genet Genome Res · 2015 Disruption in circadian gene expression, whether due to genetic variation or environmental factors (e.g., light at night, shiftwork), is associated with increased incidence of breast, prostate, gastrointestinal and hematologic cancers and gliomas. Circadia ... Full text Link to item Cite

Foreword

Journal Article · 2015 Cite

Patient preferences in advanced or recurrent ovarian cancer.

Journal Article Cancer · December 1, 2014 BACKGROUND: The objective of this study was to elucidate relative preferences of women with ovarian cancer for symptoms, treatment-related side effects, and progression-free survival (PFS) relevant to choosing a treatment regimen. METHODS: Women with advan ... Full text Link to item Cite

Biology and genetics

Chapter · November 11, 2014 Cite

LIFETIME RISK OF OVARIAN CANCER BASED ON ENDOMETRIOSIS AND OTHER RISK FACTORS

Journal Article INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER · November 1, 2014 Link to item Cite

PROPHYLACTIC OOPHORECTOMY FOR HEREDITARY SMALL-CELL CARCINOMA OF THE OVARY, HYPERCALCEMIC TYPE

Journal Article INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER · November 1, 2014 Link to item Cite

ENDOMETRIOSIS AND OVARIAN CANCER: AN INTERNATIONAL POOLED ANALYSIS

Journal Article INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER · November 1, 2014 Link to item Cite

IDENTIFICATION OF SIX NOVEL, COMMON VARIANT GENETIC SUSCEPTIBILITY LOCI FOR INVASIVE EPITHELIAL OVARIAN CANCER

Journal Article INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER · November 1, 2014 Link to item Cite

A modified bipedicle VRAM flap for simultaneous reconstruction of a perineal and posterior vaginal defect

Journal Article Gynakologe · October 14, 2014 The management of locally advanced pelvic tumors regularly requires radical surgical resection. The resection results in significant intrinsic and extrinsic pelvic defects. The advent of composite flaps has revolutionized vaginal and perineal reconstructio ... Full text Cite

Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk.

Journal Article Mol Nutr Food Res · October 2014 SCOPE: We reevaluated previously reported associations between variants in pathways of one-carbon (1-C) (folate) transfer genes and ovarian carcinoma (OC) risk, and in related pathways of purine and pyrimidine metabolism, and assessed interactions with fol ... Full text Link to item Cite

Abstract 4570: Role of ERRalpha in ovarian cancer

Conference Cancer Research · October 1, 2014 AbstractObjective. The estrogen receptor-related receptor-alpha (ERRα, encoded by ESRRA) has emerged as a key transcriptional regulator of mitochondrial function and has been implicated as a prognostic marke ... Full text Cite

Abstract 3283: GWAS identifies risk variants for mucinous ovarian carcinoma

Conference Cancer Research · October 1, 2014 AbstractBackground Genome-wide association studies (GWAS) previously identified 8 new risk loci for all subtypes of epithelial ovarian carcinoma (EOC) and one specific to invasive serous EOC. One locus, at 2 ... Full text Cite

Abstract 946: Exome genotyping array identifies rare and low-frequency variants that may be associated with ovarian cancer risk

Conference Cancer Research · October 1, 2014 AbstractBackground: Common genetic variants identified by genome-wide association studies and follow-up genotyping initiatives only explain a small proportion of the heritability of epithelial ovarian cancer ... Full text Cite

Abstract LB-89: Germ-line and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type

Conference Cancer Research · October 1, 2014 AbstractSmall-cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is an aggressive tumor and the most common type of undifferentiated ovarian malignancy presenting at less than 40 years of age. Its caus ... Full text Cite

Epigenetic determinants of ovarian clear cell carcinoma biology.

Journal Article Int J Cancer · August 1, 2014 Targeted approaches have revealed frequent epigenetic alterations in ovarian cancer, but the scope and relation of these changes to histologic subtype of disease is unclear. Genome-wide methylation and expression data for 14 clear cell carcinoma (CCC), 32 ... Full text Link to item Cite

Variation in NF-κB signaling pathways and survival in invasive epithelial ovarian cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · July 2014 Survival in epithelial ovarian cancer (EOC) is influenced by the host immune response, yet the key genetic determinants of inflammation and immunity that affect prognosis are not known. The nuclear factor-κB (NF-κB) transcription factor family plays an imp ... Full text Link to item Cite

ABCA transporter gene expression and poor outcome in epithelial ovarian cancer.

Journal Article J Natl Cancer Inst · July 2014 BACKGROUND: ATP-binding cassette (ABC) transporters play various roles in cancer biology and drug resistance, but their association with outcomes in serous epithelial ovarian cancer (EOC) is unknown. METHODS: The relationship between clinical outcomes and ... Full text Link to item Cite

Relationship between minimally invasive hysterectomy, pelvic cytology, and lymph vascular space invasion: a single institution study of 458 patients.

Journal Article Gynecol Oncol · May 2014 OBJECTIVE: The aim of this study is to determine whether a minimally invasive approach to hysterectomy is associated with an increased rate of lymph vascular space invasion (LVSI) and/or malignant pelvic peritoneal cytology in endometrial cancer. METHODS: ... Full text Link to item Cite

Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type.

Journal Article Nat Genet · May 2014 Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is the most common undifferentiated ovarian malignancy in women under 40 years of age. We sequenced the exomes of six individuals from three families with SCCOHT. After discovering segregating ... Full text Link to item Cite

Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA.

Journal Article Hum Genet · May 2014 Epithelial ovarian cancer (EOC) is a heterogeneous cancer with both genetic and environmental risk factors. Variants influencing the risk of developing the less-common EOC subtypes have not been fully investigated. We performed a genome-wide association st ... Full text Link to item Cite

Large-scale evaluation of common variation in regulatory T cell-related genes and ovarian cancer outcome.

Journal Article Cancer Immunol Res · April 2014 The presence of regulatory T cells (Treg) in solid tumors is known to play a role in patient survival in ovarian cancer and other malignancies. We assessed inherited genetic variations via 749 tag single-nucleotide polymorphisms (SNP) in 25 Treg-associated ... Full text Link to item Cite

Risk of ovarian cancer and the NF-κB pathway: genetic association with IL1A and TNFSF10.

Journal Article Cancer Res · February 1, 2014 A missense single-nucleotide polymorphism (SNP) in the immune modulatory gene IL1A has been associated with ovarian cancer risk (rs17561). Although the exact mechanism through which this SNP alters risk of ovarian cancer is not clearly understood, rs17561 ... Full text Link to item Cite

Aspirin, nonaspirin nonsteroidal anti-inflammatory drug, and acetaminophen use and risk of invasive epithelial ovarian cancer: a pooled analysis in the Ovarian Cancer Association Consortium.

Journal Article J Natl Cancer Inst · February 2014 BACKGROUND: Regular aspirin use is associated with reduced risk of several malignancies. Epidemiologic studies analyzing aspirin, nonaspirin nonsteroidal anti-inflammatory drug (NSAID), and acetaminophen use and ovarian cancer risk have been inconclusive. ... Full text Link to item Cite

Differential Angiogenic Gene Expression in TP53 Wild-Type and Mutant Ovarian Cancer Cell Lines.

Journal Article Front Oncol · 2014 OBJECTIVES: Underlying mechanisms regulating angiogenesis in ovarian cancer have not been completely elucidated. Evidence suggests that the TP53 tumor suppressor pathway and tumor microenvironment play integral roles. We utilized microarray technology to s ... Full text Link to item Cite

A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk.

Journal Article Hum Mol Genet · December 15, 2013 Mean telomere length (TL) in blood cells is heritable and has been reported to be associated with risks of several diseases, including cancer. We conducted a meta-analysis of three GWAS for TL (total n=2240) and selected 1629 variants for replication via t ... Full text Link to item Cite

Evidence of a chemopreventive effect of progestin unrelated to ovulation on reproductive tract cancers in the egg-laying hen.

Journal Article Cancer Prev Res (Phila) · December 2013 Epidemiologic, laboratory, and animal evidence suggests that progestins and vitamin D may be potent ovarian cancer preventives. Our objectives were to evaluate progestins as reproductive tract cancer chemopreventives in the chicken, determine whether restr ... Full text Link to item Cite

Molecular signatures of epithelial ovarian cancer: analysis of associations with tumor characteristics and epidemiologic risk factors.

Journal Article Cancer Epidemiol Biomarkers Prev · October 2013 BACKGROUND: Six gene expression subtypes of invasive epithelial ovarian cancer were recently defined using microarrays by Tothill and colleagues. The Cancer Genome Atlas (TCGA) project subsequently replicated these subtypes and identified a signature predi ... Full text Link to item Cite

ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas.

Journal Article Gynecol Oncol · October 2013 OBJECTIVE: ABCB1 encodes the multi-drug efflux pump P-glycoprotein (P-gp) and has been implicated in multi-drug resistance. We comprehensively evaluated this gene and flanking regions for an association with clinical outcome in epithelial ovarian cancer (E ... Full text Link to item Cite

Genital powder use and risk of ovarian cancer: a pooled analysis of 8,525 cases and 9,859 controls.

Journal Article Cancer Prev Res (Phila) · August 2013 Genital powder use has been associated with risk of epithelial ovarian cancer in some, but not all, epidemiologic investigations, possibly reflecting the carcinogenic effects of talc particles found in most of these products. Whether risk increases with nu ... Full text Link to item Cite

Timing of end-of-life care discussion with performance on end-of-life quality indicators in ovarian cancer.

Journal Article Gynecol Oncol · July 2013 OBJECTIVES: (1) To describe the prevalence, timing and setting of documented end-of-life (EOL) discussions in patients with advanced ovarian cancer; and (2) to assess the impact of timing and setting of documented end-of-life discussions on EOL quality car ... Full text Link to item Cite

Transcript expression in endometrial cancers from Black and White patients.

Journal Article Gynecol Oncol · July 2013 OBJECTIVE: Previous studies suggest that differences in molecular features of endometrial cancers between racial groups may contribute to the poorer survival in Blacks. The objective of this investigation was to determine whether gene expression among endo ... Full text Link to item Cite

Preface

Journal Article Principles and Practice of Gynecologic Oncology: Sixth Edition · May 8, 2013 Cite

Principles and practice of gynecologic oncology: Sixth edition

Book · May 8, 2013 Today, multidisciplinary approaches to treatment are at the heart of cancer care. They offer improved clinical outcomes, new possibilities in patient quality of life, and enable the development of true innovation in individualized treatment. To accurately ... Cite

Hereditary gynecologic cancers

Chapter · May 8, 2013 Cite

Integrated genomic characterization of endometrial carcinoma.

Journal Article Nature · May 2, 2013 We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array- and sequencing-based technologies. Uterine serous tumours and ∼25% of high-grade endometrioid tumours had extensive copy number alt ... Full text Link to item Cite

Analysis of over 10,000 Cases finds no association between previously reported candidate polymorphisms and ovarian cancer outcome.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2013 BACKGROUND: Ovarian cancer is a leading cause of cancer-related death among women. In an effort to understand contributors to disease outcome, we evaluated single-nucleotide polymorphisms (SNP) previously associated with ovarian cancer recurrence or surviv ... Full text Link to item Cite

Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2013 BACKGROUND: There are several well-established environmental risk factors for ovarian cancer, and recent genome-wide association studies have also identified six variants that influence disease risk. However, the interplay between such risk factors and sus ... Full text Link to item Cite

Abstract 4850: Variation in circadian rhythm genes influence epithelial ovarian cancer risk and invasiveness.

Conference Cancer Research · April 15, 2013 AbstractBackground: Circadian rhythms of biological processes are regulated by endogenous clock genes and clock-controlled genes. Aberrant expression of circadian clock genes may have important consequences ... Full text Cite

Abstract 330A: Differential expression of angiogenic genes in invasive high grade serous ovarian carcinomas.

Conference Cancer Research · April 15, 2013 AbstractOur objective is to establish quantifiable and reproducible biomarkers that can aid in prognosis, and predicting treatment outcome in invasive high-grade serous ovarian cancer (HGSC). The goal of thi ... Full text Cite

Abstract 1352: Epithelial-mesenchymal transition (EMT) gene variants influence epithelial ovarian cancer risk in women of European, African and Asian ancestry.

Conference Cancer Research · April 15, 2013 AbstractIntroductionThe epithelial-mesenchymal transition (EMT) pathway contributes to epithelial ovarian cancer (EOC) progression. Previously we identified associations of s ... Full text Cite

Abstract 4767: Preclinical mouse model of recurrent epithelial ovarian cancer.

Conference Cancer Research · April 15, 2013 AbstractPurpose: Most women diagnosed with advanced stage serous epithelial ovarian cancer exhibit a complete clinical response to surgical debulking and platinum-based chemotherapy. Remission can last month ... Full text Cite

Validation of ovarian cancer gene expression signatures for survival and subtype in formalin fixed paraffin embedded tissues.

Journal Article Gynecol Oncol · April 2013 INTRODUCTION: Gene expression signatures have been identified for epithelial ovarian cancer survival (TCGA) and intrinsic subtypes (Tothill et al.). One obstacle to clinical translation is that these signatures were developed using frozen tissue, whereas u ... Full text Link to item Cite

Vitamin D receptor (VDR) polymorphisms and risk of ovarian cancer in Caucasian and African American women.

Journal Article Gynecol Oncol · April 2013 OBJECTIVE: Polymorphisms in the vitamin D receptor (VDR) gene have been shown in some studies to be associated with the risk of epithelial ovarian cancer (EOC) in Caucasian women. There are no published reports among African Americans. METHODS: Case-contro ... Full text Link to item Cite

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.

Journal Article Nat Genet · April 2013 TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ∼480 SNPs at the TERT locus in breast (n = 103,991), ovarian (n = 39,774) and BRCA1 muta ... Full text Link to item Cite

GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.

Journal Article Nat Genet · April 2013 Genome-wide association studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC), with another two suggestive loci reaching near genome-wide significance. We pooled data from a GWAS conducted in North America with another ... Full text Link to item Cite

Tubal ligation and risk of ovarian cancer subtypes: a pooled analysis of case-control studies.

Journal Article Int J Epidemiol · April 2013 BACKGROUND: Tubal ligation is a protective factor for ovarian cancer, but it is unknown whether this protection extends to all invasive histological subtypes or borderline tumors. We undertook an international collaborative study to examine the association ... Full text Link to item Cite

BRCA1 immunohistochemistry in a molecularly characterized cohort of ovarian high-grade serous carcinomas.

Journal Article Am J Surg Pathol · January 2013 BRCA1 and BRCA2 dysfunction, frequently seen in high-grade serous ovarian carcinomas, often results from germline mutations, somatic mutations, and promoter methylation. Identification of tumors with BRCA defects has therapeutic and prognostic implications ... Full text Link to item Cite

Inherited variants in regulatory T cell genes and outcome of ovarian cancer.

Journal Article PLoS One · 2013 Although ovarian cancer is the most lethal of gynecologic malignancies, wide variation in outcome following conventional therapy continues to exist. The presence of tumor-infiltrating regulatory T cells (Tregs) has a role in outcome of this disease, and a ... Full text Link to item Cite

Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer.

Journal Article Nat Commun · 2013 HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with epithelial ovarian cancer risk ac ... Full text Link to item Cite

Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31.

Journal Article Nat Commun · 2013 Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized that variants in the 3' untranslated region at putative mi ... Full text Link to item Cite

Gene expression analysis of early stage endometrial cancers reveals unique transcripts associated with grade and histology but not depth of invasion.

Journal Article Front Oncol · 2013 Endometrial cancer is the most common gynecologic malignancy in the United States but it remains poorly understood at the molecular level. This investigation was conducted to specifically assess whether gene expression changes underlie the clinical and pat ... Full text Link to item Cite

Predictors of failure to perform pelvic peritoneal cytology in endometrial cancer staging surgery.

Journal Article J Clin Oncol · December 2012 201 Background: The Federation of Gynecology and Obstetrics (FIGO) staging system and the National Comprehensive Cancer Network (NCCN) guidelines for endometrial cancer recommend performing pelvic peritoneal cytology to look for the presence of cancer cell ... Full text Link to item Cite

A phase I trial of dasatinib, an SRC-family kinase inhibitor, in combination with paclitaxel and carboplatin in patients with advanced or recurrent ovarian cancer.

Journal Article Clin Cancer Res · October 1, 2012 PURPOSE: We conducted a phase I study of dasatinib, an oral SRC-family tyrosine kinase inhibitor, in combination with paclitaxel and carboplatin in the treatment of advanced and recurrent epithelial ovarian cancer. EXPERIMENTAL DESIGN: The primary objectiv ... Full text Link to item Cite

A multicenter, randomized, phase 2 clinical trial to evaluate the efficacy and safety of combination docetaxel and carboplatin and sequential therapy with docetaxel then carboplatin in patients with recurrent platinum-sensitive ovarian cancer.

Journal Article Cancer · July 1, 2012 BACKGROUND: The aim of this randomized clinical trial was to evaluate the efficacy and safety of combination (cDC) and sequential (sDC) weekly docetaxel and carboplatin in women with recurrent platinum-sensitive epithelial ovarian cancer (EOC). METHODS: Pa ... Full text Link to item Cite

Endometriosis and ovarian cancer - Authors' reply

Journal Article The Lancet Oncology · May 1, 2012 Full text Cite

Abstract LB-87: Methylated-mediated repression of ZNF154 in ovarian cancer is associated with poor overall survival

Journal Article Cancer Research · April 15, 2012 AbstractObjectives: Epigenetic gene regulation plays an important role in the development of cancer. We previously found that Zinc Finger Protein 154 (ZNF154), a Krüppel family zinc finger protein, is ubiqui ... Full text Cite

Abstract 5363: Aggregation rather than monoclonal expansion explains ovarian cancer spheroid formation

Journal Article Cancer Research · April 15, 2012 AbstractPurpose: It is thought that a subpopulation of ovarian cancer cells possess stem cell like properties and are responsible for both the emergence of cancer and for subsequent chemoresistance and recur ... Full text Cite

Abstract 2603: Subtype-specific ovarian cancer risk associated with SNPs in IL1A

Journal Article Cancer Research · April 15, 2012 AbstractAs pathways of the immune system play an important role in multiple malignancies, we assessed the association between single-nucleotide polymorphisms (SNPs) in inflammation-related genes and risk of ... Full text Cite

The influence of radiation modality and lymph node dissection on survival in early-stage endometrial cancer.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2012 BACKGROUND: The appropriate uses of lymph node dissection (LND) and adjuvant radiation therapy (RT) for Stage I endometrial cancer are controversial. We explored the impact of specific RT modalities (whole pelvic RT [WPRT], vaginal brachytherapy [VB]) and ... Full text Link to item Cite

Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies.

Journal Article Lancet Oncol · April 2012 BACKGROUND: Endometriosis is a risk factor for epithelial ovarian cancer; however, whether this risk extends to all invasive histological subtypes or borderline tumours is not clear. We undertook an international collaborative study to assess the associati ... Full text Link to item Cite

Role of common genetic variants in ovarian cancer susceptibility and outcome: progress to date from the Ovarian Cancer Association Consortium (OCAC).

Journal Article J Intern Med · April 2012 In this article, we review the current knowledge of the inherited genetics of epithelial ovarian cancer (EOC) susceptibility and clinical outcome. We focus on recent developments in identifying low-penetrance susceptibility genes and the role of the Ovaria ... Full text Link to item Cite

Common variation in Nemo-like kinase is associated with risk of ovarian cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2012 BACKGROUND: Overexpression of mitotic kinases has been associated with prognosis, histologic grade, and clinical stage in ovarian cancer, but the relationship between inherited variation in these genes and ovarian cancer risk has not been well defined. MET ... Full text Link to item Cite

Ovarian cancer risk associated with inherited inflammation-related variants.

Journal Article Cancer Res · March 1, 2012 The importance of inflammation pathways to the development of many human cancers prompted us to examine the associations between single-nucleotide polymorphisms (SNP) in inflammation-related genes and risk of ovarian cancer. In a multisite case-control stu ... Full text Link to item Cite

Nonsteroidal antiinflammatory drugs and progestins synergistically enhance cell death in ovarian epithelial cells.

Journal Article Am J Obstet Gynecol · March 2012 OBJECTIVE: There is growing evidence that progestins and nonsteroidal antiinflammatory drugs (NSAIDs) may prevent ovarian cancer. Because both induce apoptosis, we investigated the potential for synergistic impact of combined drug treatment on cell death. ... Full text Link to item Cite

Cost-effectiveness of combination versus sequential docetaxel and carboplatin for the treatment of platinum-sensitive, recurrent ovarian cancer.

Journal Article Cancer · January 15, 2012 BACKGROUND: In a randomized controlled trial (RCT) of patients with recurrent, platinum-sensitive ovarian cancer, the combination weekly docetaxel and carboplatin was associated a with progression-free survival (PFS) of 13.7 months compared with 8.4 months ... Full text Link to item Cite

Loss of ARID1A-associated protein expression is a frequent event in clear cell and endometrioid ovarian cancers.

Journal Article Int J Gynecol Cancer · January 2012 BACKGROUND: Inactivating somatic mutations in the ARID1A gene are described in a significant fraction of clear cell and endometrioid ovarian cancers leading to loss of the corresponding protein (BAF250a). Expression of BAF250a was examined in clear cell an ... Full text Link to item Cite

Analysis of PSPHL as a Candidate Gene Influencing the Racial Disparity in Endometrial Cancer.

Journal Article Front Oncol · 2012 Endometrial cancer is the most commonly diagnosed gynecologic malignancy in the United States. A well recognized disparity by race in both incidence and survival outcome exists for this cancer. Specifically Caucasians are about two times more likely to dev ... Full text Link to item Cite

Regular Multivitamin Supplement Use, Single Nucleotide Polymorphisms in ATIC, SHMT2, and SLC46A1, and Risk of Ovarian Carcinoma.

Journal Article Front Genet · 2012 ATIC, SHMT2, and SLC46A1 have essential roles in one-carbon (1-C) transfer. The authors examined whether associations between ovarian carcinoma and 15 variants in these genes are modified by regular multivitamin use, a source of 1-C donors, among Caucasian ... Full text Link to item Cite

Ovarian cancer progenitor/stem cells: Therapeutic potential

Journal Article · December 1, 2011 A number of studies provide evidence for the existence of ovarian cancer stem cells, defined by functional attributes, foremost the ability to reconstruct the heterogeneity of the original tumor in immunocompromised mice through asymmetric cell division. A ... Full text Cite

Quantitative detection of RASSF1A DNA promoter methylation in tumors and serum of patients with serous epithelial ovarian cancer.

Journal Article Gynecol Oncol · December 2011 OBJECTIVE: Detection of cell free tumor-specific DNA methylation has been proposed as a potentially useful noninvasive mechanism to detect malignancies, including ovarian cancer, and to monitor response to treatment. However, there are few easily implement ... Full text Link to item Cite

BAD phosphorylation determines ovarian cancer chemosensitivity and patient survival.

Journal Article Clin Cancer Res · October 1, 2011 PURPOSE: Despite initial sensitivity to chemotherapy, ovarian cancers (OVCA) often develop drug resistance, which limits patient survival. Using specimens and/or genomic data from 289 patients and a panel of cancer cell lines, we explored genome-wide expre ... Full text Link to item Cite

What Are The Causes Of Death For Women With Early-stage Endometrial Cancer?

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Rethinking ovarian cancer: recommendations for improving outcomes.

Journal Article Nat Rev Cancer · September 23, 2011 There have been major advances in our understanding of the cellular and molecular biology of the human malignancies that are collectively referred to as ovarian cancer. At a recent Helene Harris Memorial Trust meeting, an international group of researchers ... Full text Link to item Cite

Large prospective study of ovarian cancer screening in high-risk women: CA125 cut-point defined by menopausal status.

Journal Article Cancer Prev Res (Phila) · September 2011 Previous screening trials for early detection of ovarian cancer in postmenopausal women have used the standard CA125 cut-point of 35 U/mL, the 98th percentile in this population yielding a 2% false positive rate, whereas the same cut-point in trials of pre ... Full text Link to item Cite

Cost comparison of strategies for the management of venous thromboembolic event risk following laparotomy for ovarian cancer.

Journal Article Gynecol Oncol · September 2011 OBJECTIVE: To evaluate the costs and effectiveness of thromboprophylaxis strategies following laparotomy for ovarian cancer. METHODS: We constructed a decision model to evaluate six strategies for management of postoperative venous thromboembolism (VTE) ri ... Full text Link to item Cite

MicroRNA processing and binding site polymorphisms are not replicated in the Ovarian Cancer Association Consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · August 2011 BACKGROUND: Single nucleotide polymorphisms (SNP) in microRNA-related genes have been associated with epithelial ovarian cancer (EOC) risk in two reports, yet associated alleles may be inconsistent across studies. METHODS: We conducted a pooled analysis of ... Full text Link to item Cite

Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines.

Journal Article Cancer Res · August 1, 2011 Cancer cells are defined by their ability to invade through the basement membrane, a critical step during metastasis. While increased secretion of proteases, which facilitates degradation of the basement membrane, and alterations in the cytoskeletal archit ... Full text Link to item Cite

Adverse events associated with laparoscopy vs laparotomy in the treatment of endometrial cancer.

Journal Article Am J Obstet Gynecol · August 2011 OBJECTIVE: The objective of the study was to compare adverse event rates between laparoscopic vs open surgery for endometrial cancer. STUDY DESIGN: This was a retrospective cohort study comparing 107 women who underwent laparoscopy with 269 age- and body m ... Full text Link to item Cite

Integrated genomic analyses of ovarian carcinoma.

Journal Article Nature · June 29, 2011 A catalogue of molecular aberrations that cause ovarian cancer is critical for developing and deploying therapies that will improve patients' lives. The Cancer Genome Atlas project has analysed messenger RNA expression, microRNA expression, promoter methyl ... Full text Link to item Cite

Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk.

Journal Article Hum Mol Genet · June 1, 2011 The insulin-like growth factor (IGF) signaling axis plays an important role in cancer biology. We hypothesized that genetic variation in this pathway may influence risk of ovarian cancer. A three-center study of non-Hispanic whites including 1880 control w ... Full text Link to item Cite

The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing.

Journal Article Clin Cancer Res · June 1, 2011 PURPOSE: An assay for the single-nucleotide polymorphism (SNP), rs61764370, has recently been commercially marketed as a clinical test to aid ovarian cancer risk evaluation in women with family histories of the disease. rs67164370 is in a 3'-UTR miRNA bind ... Full text Link to item Cite

Proteomic analysis of stage I endometrial cancer tissue: identification of proteins associated with oxidative processes and inflammation.

Journal Article Gynecol Oncol · June 1, 2011 OBJECTIVE: The present study aimed to identify differentially expressed proteins employing a high resolution mass spectrometry (MS)-based proteomic analysis of endometrial cancer cells harvested using laser microdissection. METHODS: A differential MS-based ... Full text Link to item Cite

Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer.

Journal Article Int J Cancer · May 1, 2011 Common germline genetic variation in the population is associated with susceptibility to epithelial ovarian cancer. Microcell-mediated chromosome transfer and expression microarray analysis identified nine genes associated with functional suppression of tu ... Full text Link to item Cite

Xenobiotic-Metabolizing gene polymorphisms and ovarian cancer risk.

Journal Article Mol Carcinog · May 2011 Because selected xenobiotic-metabolizing enzymes process pro-carcinogens that could initiate ovarian carcinogenesis, we hypothesized that single nucleotide polymorphisms (SNPs) in the genes encoding xenobiotic-metabolizing enzymes are associated with risk ... Full text Link to item Cite

Prostate cancer susceptibility polymorphism rs2660753 is not associated with invasive ovarian cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2011 BACKGROUND: We previously reported an association between rs2660753, a prostate cancer susceptibility polymorphism, and invasive epithelial ovarian cancer (EOC; OR = 1.2, 95% CI=1.0-1.4, P(trend) = 0.01) that showed a stronger association with the serous h ... Full text Link to item Cite

Abstract 3014: Quantitative accuracy of Illumina HumanMethylation27 Infinium BeadChip data assessed by pyrosequencing

Journal Article Cancer Research · April 15, 2011 AbstractPurpose. Aberrant DNA methylation can lead to changes in gene expression, and this alteration is highly relevant in the context of cancer. The ability to accurately assess DNA methylation status is t ... Full text Cite

Dasatinib (BMS-35482) has synergistic activity with paclitaxel and carboplatin in ovarian cancer cells.

Journal Article Gynecol Oncol · April 2011 PURPOSE: To explore the activity of dasatinib alone and in combination with paclitaxel and carboplatin in ovarian cancer cells and to determine if dasatinib activity can be predicted based on evaluation of the SRC pathway. EXPERIMENTAL DESIGN: Microarray a ... Full text Link to item Cite

Prevention and early detection of cancer.

Journal Article Gynecol Oncol · April 2011 Full text Link to item Cite

Reduction of ovarian and oviductal cancers in calorie-restricted laying chickens.

Journal Article Cancer Prev Res (Phila) · April 2011 Epithelial ovarian cancer (OVAC) remains a highly lethal malignancy. It is a leading cause of cancer deaths among women in the United States causing more deaths than all other gynecologic malignancies combined. The pathogenesis of OVAC is not completely un ... Full text Link to item Cite

BAD apoptosis pathway expression and survival from cancer

Journal Article Gynecologic Oncology · March 2011 Full text Cite

Development of an ovarian cancer screening decision model that incorporates disease heterogeneity: implications for potential mortality reduction.

Journal Article Cancer · February 1, 2011 BACKGROUND: Pathologic and genetic data suggest that epithelial ovarian cancer may consist of indolent and aggressive phenotypes. The objective of the current study was to estimate the impact of a 2-phenotype paradigm of epithelial ovarian cancer on the mo ... Full text Link to item Cite

Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer.

Journal Article Genome Res · January 2011 Epithelial ovarian cancer is the leading cause of death among gynecologic malignancies. Diagnosis usually occurs after metastatic spread, largely reflecting vague symptoms of early disease combined with lack of an effective screening strategy. Epigenetic m ... Full text Link to item Cite

Polymorphisms in stromal genes and susceptibility to serous epithelial ovarian cancer: a report from the Ovarian Cancer Association Consortium.

Journal Article PLoS One · 2011 Alterations in stromal tissue components can inhibit or promote epithelial tumorigenesis. Decorin (DCN) and lumican (LUM) show reduced stromal expression in serous epithelial ovarian cancer (sEOC). We hypothesized that common variants in these genes associ ... Full text Link to item Cite

Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort.

Journal Article Fertil Steril · January 2011 OBJECTIVE: To investigate the association between self-reported endometriosis and the putative functional promoter +331C/T single nucleotide polymorphism and the PROGINS allele. DESIGN: Control subjects from ovarian cancer case-control studies participatin ... Full text Link to item Cite

Estrogen receptor beta rs1271572 polymorphism and invasive ovarian carcinoma risk: pooled analysis within the Ovarian Cancer Association Consortium.

Journal Article PLoS One · 2011 The association of ovarian carcinoma risk with the polymorphism rs1271572 in the estrogen receptor beta (ESR2) gene was examined in 4946 women with primary invasive ovarian carcinoma and 6582 controls in a pooled analysis of ten case-control studies within ... Full text Link to item Cite

Genome-scale screen for DNA methylation-based detection markers for ovarian cancer.

Journal Article PLoS One · 2011 BACKGROUND: The identification of sensitive biomarkers for the detection of ovarian cancer is of high clinical relevance for early detection and/or monitoring of disease recurrence. We developed a systematic multi-step biomarker discovery and verification ... Full text Link to item Cite

Projecting the need for gynecologic oncologists for the next 40 years.

Journal Article Obstet Gynecol · December 2010 OBJECTIVE: To estimate the ratio of gynecologic cancer cases to practicing gynecologic oncologists in the United States over the next 40 years. METHODS: Using population projections from the U.S. Census Bureau and incidence and mortality rates from Surveil ... Full text Link to item Cite

Secondary Malignancy after Radiation for Endometrial Cancer: Comparing No Radiation, External Beam, and Brachytherapy

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.

Journal Article Nat Genet · October 2010 Ovarian cancer accounts for more deaths than all other gynecological cancers combined. To identify common low-penetrance ovarian cancer susceptibility genes, we conducted a genome-wide association study of 507,094 SNPs in 1,768 individuals with ovarian can ... Full text Link to item Cite

Common variants at 19p13 are associated with susceptibility to ovarian cancer.

Journal Article Nat Genet · October 2010 Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 indi ... Full text Link to item Cite

Prophylactic and risk-reducing bilateral salpingo-oophorectomy: recommendations based on risk of ovarian cancer.

Journal Article Obstet Gynecol · September 2010 Women who do not have a documented germline mutation or who do not have a strong family history suspicious for a germline mutation are considered to be at average risk of ovarian cancer. Women who have confirmed deleterious BRCA1 and BRCA2 germline mutatio ... Full text Link to item Cite

Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".

Journal Article PLoS Genet · July 8, 2010 We hypothesized that variants in genes expressed as a consequence of interactions between ovarian cancer cells and the host micro-environment could contribute to cancer susceptibility. We therefore used a two-stage approach to evaluate common single nucleo ... Full text Link to item Cite

Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · July 2010 BACKGROUND: We previously reported the risks of ovarian carcinoma for common polymorphisms in one-carbon transfer genes. We sought to replicate associations for DPYD rs1801265, DNMT3A rs13420827, MTHFD1 rs1950902, MTHFS rs17284990, and TYMS rs495139 with r ... Full text Link to item Cite

Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".

Journal Article PLoS genetics · July 1, 2010 We hypothesized that variants in genes expressed as a consequence of interactions between ovarian cancer cells and the host micro-environment could contribute to cancer susceptibility. We therefore used a two-stage approach to evaluate common single nucleo ... Cite

Microcell-mediated chromosome transfer identifies EPB41L3 as a functional suppressor of epithelial ovarian cancers.

Journal Article Neoplasia · July 2010 We used a functional complementation approach to identify tumor-suppressor genes and putative therapeutic targets for ovarian cancer. Microcell-mediated transfer of chromosome 18 in the ovarian cancer cell line TOV21G induced in vitro and in vivo neoplasti ... Full text Link to item Cite

Expression signatures of TP53 mutations in serous ovarian cancers.

Journal Article BMC Cancer · May 26, 2010 BACKGROUND: Mutations in the TP53 gene are extremely common and occur very early in the progression of serous ovarian cancers. Gene expression patterns that relate to mutational status may provide insight into the etiology and biology of the disease. METHO ... Full text Open Access Link to item Cite

Targeting slow-proliferating ovarian cancer cells.

Journal Article Int J Cancer · May 15, 2010 Advanced ovarian cancer has a high rate of recurrence and mortality despite relative chemosensitivity at the time of initial treatment. Conventional chemotherapeutic agents typically target rapidly dividing cells. Disease relapse may therefore result from ... Full text Link to item Cite

Association between DNA damage response and repair genes and risk of invasive serous ovarian cancer.

Journal Article PLoS One · April 8, 2010 BACKGROUND: We analyzed the association between 53 genes related to DNA repair and p53-mediated damage response and serous ovarian cancer risk using case-control data from the North Carolina Ovarian Cancer Study (NCOCS), a population-based, case-control st ... Full text Open Access Link to item Cite

Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer.

Journal Article Int J Cancer · March 15, 2010 We previously found that the gene encoding the Myelin and Lymphocyte protein, MAL, was among the most highly expressed genes in serous ovarian cancers from short-term survivors (<3 years) relative to those of long-term survivors (>7 years). In the present ... Full text Link to item Cite

Ovarian cancer tumor infiltrating T-regulatory (T(reg)) cells are associated with a metastatic phenotype.

Journal Article Gynecol Oncol · March 2010 OBJECTIVE: The objective of this study was to examine the clinicopathologic correlates of T-regulatory (T(reg)) cell infiltration in serous ovarian cancers and to define gene signatures associated with high T(reg)s. METHODS: Tumor infiltrating T(reg) and c ... Full text Link to item Cite

Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer.

Journal Article Twin Res Hum Genet · February 2010 The chromosome 8q24 region (specifically, 8q24.21.a) is known to harbor variants associated with risk of breast, colorectal, prostate, and bladder cancers. In 2008, variants rs10505477 and rs6983267 in this region were associated with increased risk of inv ... Full text Link to item Cite

Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · February 2010 Aberrant glycosylation is a well-described hallmark of cancer. In a previous ovarian cancer case control study that examined polymorphisms in 26 glycosylation-associated genes, we found strong statistical evidence (P = 0.00017) that women who inherited two ... Full text Link to item Cite

Risk of ovarian cancer and inherited variants in relapse-associated genes.

Journal Article PLoS One · January 27, 2010 BACKGROUND: We previously identified a panel of genes associated with outcome of ovarian cancer. The purpose of the current study was to assess whether variants in these genes correlated with ovarian cancer risk. METHODS AND FINDINGS: Women with and withou ... Full text Open Access Link to item Cite

High poly(adenosine diphosphate-ribose) polymerase expression and poor survival in advanced-stage serous ovarian cancer.

Journal Article Obstet Gynecol · January 2010 OBJECTIVE: To estimate the range of poly(adenosine diphosphate [ADP]-ribose) polymerase expression in serous ovarian cancers and to determine whether expression is associated with response to therapy and outcome. METHODS: Immunostaining for poly(ADP-ribose ... Full text Link to item Cite

ESR1/SYNE1 polymorphism and invasive epithelial ovarian cancer risk: an Ovarian Cancer Association Consortium study.

Journal Article Cancer Epidemiol Biomarkers Prev · January 2010 We genotyped 13 single nucleotide polymorphisms (SNPs) in the estrogen receptor alpha gene (ESR1) region in three population-based case-control studies of epithelial ovarian cancer conducted in the United States, comprising a total of 1,128 and 1,866 non-H ... Full text Link to item Cite

Association between the N-terminally truncated (DeltaN) p63alpha (DeltaNp63alpha) isoform and debulking status, VEGF expression and progression-free survival in previously untreated, advanced stage epithelial ovarian cancer: A Gynecologic Oncology Group study.

Journal Article Gynecol Oncol · December 2009 OBJECTIVES: The Gynecologic Oncology Group (GOG) examined the association between the relative expression of the DeltaNp63alpha isoform and clinicopathologic variables, p53 status, angiogenic markers, progression-free survival (PFS) and overall survival (O ... Full text Link to item Cite

Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.

Journal Article Br J Cancer · October 20, 2009 BACKGROUND: Dysregulation of the cell cycle is a hallmark of many cancers including ovarian cancer, a leading cause of gynaecologic cancer mortality worldwide. METHODS: We examined single nucleotide polymorphisms (SNPs) (n=288) from 39 cell cycle regulatio ... Full text Link to item Cite

A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2.

Journal Article Nat Genet · September 2009 Epithelial ovarian cancer has a major heritable component, but the known susceptibility genes explain less than half the excess familial risk. We performed a genome-wide association study (GWAS) to identify common ovarian cancer susceptibility alleles. We ... Full text Link to item Cite

Ovarian cancer risk factors in African-American and white women.

Journal Article Am J Epidemiol · September 1, 2009 Ovarian cancer is the most lethal gynecologic malignancy in both African-American and white women. Although prevalences of many ovarian cancer risk factors differ markedly between African Americans and whites, there has been little research on how the rela ... Full text Link to item Cite

MLH1 expression sensitises ovarian cancer cells to cell death mediated by XIAP inhibition.

Journal Article Br J Cancer · July 21, 2009 BACKGROUND: The X-linked inhibitor of apoptosis protein (XIAP), an endogenous apoptosis suppressor, can determine the level of caspase accumulation and the resultant response to apoptosis-inducing agents such as cisplatin in epithelial ovarian cancer (EOC) ... Full text Link to item Cite

Evaluation of two management strategies for preoperative grade 1 endometrial cancer.

Journal Article Obstet Gynecol · July 2009 OBJECTIVE: To compare the practices, adjuvant treatment, and outcomes of patients with preoperatively assessed grade 1 endometrioid endometrial cancer between two academic gynecologic oncology centers that use different treatment strategies. METHODS: A ret ... Full text Link to item Cite

Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study.

Journal Article Hum Mol Genet · June 15, 2009 Because both ovarian and breast cancer are hormone-related and are known to have some predisposition genes in common, we evaluated 11 of the most significant hits (six with confirmed associations with breast cancer) from the breast cancer genome-wide assoc ... Full text Link to item Cite

UCN-01 is effective in targeting ovarian cancer spheroids

Journal Article CANCER RESEARCH · May 1, 2009 Link to item Cite

Microarray analysis of early stage serous ovarian cancers shows profiles predictive of favorable outcome.

Journal Article Clin Cancer Res · April 1, 2009 Featured Publication PURPOSE: Although few women with advanced serous ovarian cancer are cured, detection of the disease at an early stage is associated with a much higher likelihood of survival. We previously used gene expression array analysis to distinguish subsets of advan ... Full text Link to item Cite

Role of genetic polymorphisms and ovarian cancer susceptibility.

Journal Article Mol Oncol · April 2009 The value of identifying women with an inherited predisposition to epithelial ovarian cancer has become readily apparent with the identification of the BRCA1, and BRCA2 genes. Women who inherit a deleterious mutation in either of these genes have a very hi ... Full text Link to item Cite

Single nucleotide polymorphisms in the TP53 region and susceptibility to invasive epithelial ovarian cancer.

Journal Article Cancer Res · March 15, 2009 Featured Publication The p53 protein is critical for multiple cellular functions including cell growth and DNA repair. We assessed whether polymorphisms in the region encoding TP53 were associated with risk of invasive ovarian cancer. The study population includes a total of 5 ... Full text Link to item Cite

Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31, CD105, p53 status, and angiogenic marker expression: A Gynecologic Oncology Group study.

Journal Article Gynecol Oncol · March 2009 OBJECTIVES: The aims of this study were to examine prognostic significance of microvessel density (MVD) in previously-untreated, advanced epithelial ovarian cancer (EOC) and explore associations between MVD and factors that affect angiogenesis. METHODS: MV ... Full text Link to item Cite

Yin yang 1 modulates taxane response in epithelial ovarian cancer.

Journal Article Mol Cancer Res · February 2009 Survival of ovarian cancer patients is largely dictated by their response to chemotherapy, which depends on underlying molecular features of the malignancy. We previously identified YIN YANG 1 (YY1) as a gene whose expression is positively correlated with ... Full text Link to item Cite

Ovarian adenocarcinomas in the laying hen and women share similar alterations in p53, ras, and HER-2/neu.

Journal Article Cancer Prev Res (Phila) · February 2009 We examined alterations in the p53 tumor suppressor gene and the ras and HER-2/neu oncogenes in chicken ovarian cancers to determine if these tumors have genetic alterations similar to those in human ovarian adenocarcinomas. Mutations in the p53 tumor supp ... Full text Link to item Cite

Genomic predictors of ovarian cancer response to salvage therapy

Journal Article GYNECOLOGIC ONCOLOGY · February 1, 2009 Link to item Cite

Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium.

Journal Article Br J Cancer · January 27, 2009 The search for genetic variants associated with ovarian cancer risk has focused on pathways including sex steroid hormones, DNA repair, and cell cycle control. The Ovarian Cancer Association Consortium (OCAC) identified 10 single-nucleotide polymorphisms ( ... Full text Link to item Cite

Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells.

Journal Article Oncogene · January 15, 2009 Featured Publication The cancer stem cell hypothesis posits that malignant growth arises from a rare population of progenitor cells within a tumor that provide it with unlimited regenerative capacity. Such cells also possess increased resistance to chemotherapeutic agents. Res ... Full text Link to item Cite

Robotic-assisted laparoscopic gynecologic procedures in a fellowship training program.

Journal Article JSLS · 2009 BACKGROUND AND OBJECTIVE: The robotic surgical platform is an alternative technique to traditional laparoscopy and requires the development of new surgical skills for both the experienced surgeon and trainee. Our goal was to perform an early evaluation of ... Full text Link to item Cite

Relationship between tamoxifen use and high risk endometrial cancer histologic types.

Journal Article Gynecol Oncol · January 2009 OBJECTIVES: We wished to determine whether a pre-existing diagnosis of breast cancer or the use of tamoxifen among patients with pre-existing breast cancer influences the histologic type of subsequently diagnosed endometrial carcinoma, the interval between ... Full text Link to item Cite

Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.

Journal Article Cancer Epidemiol Biomarkers Prev · December 2008 Featured Publication Over 22,000 cases of ovarian cancer were diagnosed in 2007 in the United States, but only a fraction of them can be attributed to mutations in highly penetrant genes such as BRCA1. To determine whether low-penetrance genetic variants contribute to ovarian ... Full text Link to item Cite

Evaluation of biomarker panels for early stage ovarian cancer detection and monitoring for disease recurrence.

Journal Article Gynecol Oncol · September 2008 Featured Publication OBJECTIVE: To determine the utility of novel combinations of biomarkers, using both a one-step and two-step assay format, to distinguish serum of early ovarian cancer patients from that of healthy controls and to discern the utility of these biomarkers in ... Full text Link to item Cite

Consortium analysis of 7 candidate SNPs for ovarian cancer.

Journal Article Int J Cancer · July 15, 2008 The Ovarian Cancer Association Consortium selected 7 candidate single nucleotide polymorphisms (SNPs), for which there is evidence from previous studies of an association with variation in ovarian cancer or breast cancer risks. The SNPs selected for analys ... Full text Link to item Cite

Scientific innovation--pathway to progress in women's cancer.

Journal Article Gynecol Oncol · June 2008 Featured Publication Full text Link to item Cite

Gene expression determinants of ovarian cancer platinum-response in older women.

Journal Article J Clin Oncol · May 20, 2008 22059 Background: Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy, and more than half of new ovarian cancer cases arise in women over age 65. Although older women with EOC have poorer overall prognosis compared to younger women, t ... Link to item Cite

Gene expression determinants of ovarian cancer platinum-response in older women

Journal Article Journal of Clinical Oncology · May 20, 2008 Full text Cite

Hormonal risk factors for ovarian cancer in premenopausal and postmenopausal women.

Journal Article Am J Epidemiol · May 1, 2008 Ovarian cancer is most frequently diagnosed in postmenopausal women; however, the strongest risk predictors, pregnancy and oral contraceptive use, occur in most women in their twenties and thirties. Relatively few studies have examined how reproductive ris ... Full text Link to item Cite

Cyclin E overexpression in epithelial ovarian cancer characterizes an etiologic subgroup.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2008 Featured Publication BACKGROUND: The objective of this study was to determine whether cyclin E overexpression defines an etiologically distinct subgroup of ovarian cancer. METHODS: We analyzed data from 538 epithelial ovarian cancer cases and 629 controls enrolled in a populat ... Full text Link to item Cite

Targeting dormant ovarian cancer cells

Journal Article GYNECOLOGIC ONCOLOGY · March 1, 2008 Link to item Cite

Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the Ovarian Cancer Association Consortium pooled analysis.

Journal Article Br J Cancer · January 29, 2008 Featured Publication There is evidence that progesterone plays a role in the aetiology of invasive epithelial ovarian cancer. Therefore, genes involved in pathways that regulate progesterone may be candidates for susceptibility to this disease. Previous studies have suggested ... Full text Link to item Cite

A multi-institutional evaluation of factors predictive of toxicity and efficacy of bevacizumab for recurrent ovarian cancer.

Journal Article Int J Gynecol Cancer · 2008 While bevacizumab has shown activity in recurrent ovarian cancer, a higher than expected incidence of bowel perforations has been reported in recent trials. We sought to determine factors associated with toxicity and tumor response in patients with relapse ... Full text Link to item Cite

Combining multiple serum tumor markers improves detection of stage I epithelial ovarian cancer.

Journal Article Gynecol Oncol · December 2007 OBJECTIVE: Currently available tumor markers for ovarian cancer are still inadequate in both sensitivity and specificity to be used for population-based screening. Artificial neural network (ANN) as a modeling tool has demonstrated its ability to assimilat ... Full text Link to item Cite

The role of multi-modality adjuvant chemotherapy and radiation in women with advanced stage endometrial cancer.

Journal Article Gynecol Oncol · November 2007 OBJECTIVE: : The optimal adjuvant therapy for women with stages III and IV endometrial cancer following surgical staging and cytoreductive surgery is controversial. We sought to determine the outcome of patients with advanced stage endometrial cancer treat ... Full text Link to item Cite

Society of Gynecologic Oncologists Education Committee statement on risk assessment for inherited gynecologic cancer predispositions.

Journal Article Gynecol Oncol · November 2007 Women with germline mutations in the cancer susceptibility genes, BRCA1 or BRCA2, associated with Hereditary Breast/Ovarian Cancer syndrome, have up to an 85% lifetime risk of breast cancer and up to a 46% lifetime risk ovarian cancer. Similarly, women wit ... Full text Link to item Cite

Overexpression of folate binding protein is associated with shortened progression-free survival in uterine adenocarcinomas.

Journal Article Gynecol Oncol · October 2007 OBJECTIVES: Oligonucleotide array and tissue microarray analysis (TMA) by our group has revealed that folate binding protein (FOLR1) is overexpressed in some types of uterine cancer, particularly tumors with serous histology. Since FOLR1 overexpression is ... Full text Link to item Cite

Co-expression of angiogenic markers and associations with prognosis in advanced epithelial ovarian cancer: a Gynecologic Oncology Group study.

Journal Article Gynecol Oncol · July 2007 OBJECTIVES: The aim of this study was to explore the co-expression and prognostic relevance of thrombospondin-1 (THBS-1), basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF) and VEGF receptor 1 (VEGFR-1) in epithelial ovarian c ... Full text Link to item Cite

The role of genetic testing for cancer susceptibility in gynecologic practice.

Journal Article Obstet Gynecol · July 2007 Genetic counseling and testing for inherited disorders are part of every obstetrician-gynecologist's practice. Family history, ethnicity, and race are routinely evaluated as a part of the prenatal assessment. The discovery of genes responsible for inherite ... Full text Link to item Cite

Outcomes in surgical stage I uterine papillary serous carcinoma.

Journal Article Gynecol Oncol · June 2007 OBJECTIVE: The optimal management of patients with stage I uterine papillary serous carcinoma (UPSC) is unclear. We sought to determine whether outcomes of women with surgical stage I UPSC differ with and without adjuvant therapy. METHODS: Retrospective mu ... Full text Link to item Cite

Overexpression of folate binding protein and mesothelin are associated with uterine serous carcinoma.

Journal Article Gynecol Oncol · June 2007 PURPOSE: Folate receptor alpha (FOLR1) is a membrane bound receptor involved in the transport of folate as well as other regulatory cellular processes. The purpose of this study was to examine the expression of FOLR1 in uterine cancers and to identify chan ... Full text Link to item Cite

Regulation of the metastasis suppressor gene MKK4 in ovarian cancer.

Journal Article Gynecol Oncol · May 2007 Featured Publication OBJECTIVES: MKK4 is a metastasis suppressor that is downregulated in some ovarian cancers. We sought to investigate whether promoter methylation, loss of heterozygosity, or changes in phosphorylation are involved in MKK4 dysregulation during ovarian carcin ... Full text Link to item Cite

Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer.

Journal Article Cancer Res · April 1, 2007 High-risk susceptibility genes explain <40% of the excess risk of familial ovarian cancer. Therefore, other ovarian cancer susceptibility genes are likely to exist. We have used a single nucleotide polymorphism (SNP)-tagging approach to evaluate common var ... Full text Link to item Cite

Global expression analysis of cancer/testis genes in uterine cancers reveals a high incidence of BORIS expression.

Journal Article Clin Cancer Res · March 15, 2007 PURPOSE: Cancer/testis (CT) genes predominantly expressed in the testis (germ cells) and generally not in other normal tissues are aberrantly expressed in human cancers. This highly restricted expression provides a unique opportunity to use these CT genes ... Full text Link to item Cite

Trinucleotide repeat polymorphisms in the androgen receptor gene and risk of ovarian cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2007 INTRODUCTION: Androgens may play a role in the development of ovarian cancers. Two trinucleotide repeat polymorphisms have been described in exon 1 of the androgen receptor (AR) gene that may affect its function. Previous studies of ovarian cancer and AR r ... Full text Link to item Cite

Society of gynecologic oncologists

Journal Article Journal of Oncology Practice · March 1, 2007 Full text Cite

An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer.

Other J Clin Oncol · February 10, 2007 Featured Publication PURPOSE: The purpose of this study was to develop an integrated genomic-based approach to personalized treatment of patients with advanced-stage ovarian cancer. We have used gene expression profiles to identify patients likely to be resistant to primary pl ... Full text Link to item Cite

Magellan: a web based system for the integrated analysis of heterogeneous biological data and annotations; application to DNA copy number and expression data in ovarian cancer.

Journal Article Cancer Inform · February 5, 2007 Recent advances in high throughput biological methods allow researchers to generate enormous amounts of data from a single experiment. In order to extract meaningful conclusions from this tidal wave of data, it will be necessary to develop analytical metho ... Link to item Cite

Weekly low-dose paclitaxel and carboplatin in the treatment of advanced or recurrent cervical and endometrial cancer.

Journal Article Int J Clin Oncol · February 2007 BACKGROUND: The purpose of this study was to evaluate the toxicity profile of weekly low-dose paclitaxel and carboplatin in patients with gynecologic malignancies. METHODS: Patients had measurable disease defined by clinical examination or radiographic stu ... Full text Link to item Cite

The prognostic significance of positive peritoneal cytology and adnexal/serosal metastasis in stage IIIA endometrial cancer.

Journal Article Gynecol Oncol · February 2007 OBJECTIVE: The clinical significance and optimal management of patients with stage IIIA endometrial cancer are controversial. We sought to determine whether recurrence and survival of patients with stage IIIA endometrial cancer differ with surgical patholo ... Full text Link to item Cite

Comparison of gracilis and rectus abdominis myocutaneous flap neovaginal reconstruction performed during radical pelvic surgery: flap-specific morbidity.

Journal Article Int J Gynecol Cancer · 2007 To compare flap-specific complications of gracilis myocutaneous (GM) and rectus abdominis myocutaneous (RAM) flap neovaginal reconstructions after radical pelvic surgery. The study was a single-institution retrospective review of patients undergoing concur ... Full text Link to item Cite

Gene Expression Patterns Identify Patients with Non-Small Cell Lung Cancer (NSCLC) and Ovarian Cancer Who Are at Increased Risk for Venous Thromboembolism (VTE).

Conference Blood · November 16, 2006 AbstractBackground: VTE is the leading cause of death in patients with cancer. The 1-year survival rate in patients diagnosed with cancer at time of VTE is 12% compared to 36% in cancer patients without thro ... Full text Cite

Genomic signatures to guide the use of chemotherapeutics.

Other Nat Med · November 2006 Featured Publication Using in vitro drug sensitivity data coupled with Affymetrix microarray data, we developed gene expression signatures that predict sensitivity to individual chemotherapeutic drugs. Each signature was validated with response data from an independent set of ... Full text Link to item Cite

Progestin and estrogen potency of combination oral contraceptives and endometrial cancer risk.

Journal Article Gynecol Oncol · November 2006 OBJECTIVE: Using data from a case-control study of endometrial cancer, we investigated the relationship between the progestin and estrogen potency in combination oral contraceptives (OCs) and the risk of developing endometrial cancer. METHODS: Subjects inc ... Full text Link to item Cite

... what about this mole?

Journal Article Contemporary Ob/Gyn · November 1, 2006 Cite

ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes.

Journal Article J Clin Oncol · October 1, 2006 Featured Publication Although the etiology of solid cancers is multifactorial, with environmental and genetic factors playing a variable role, a significant portion of the burden of cancer is accounted for by a heritable component. Increasingly, the heritable component of canc ... Full text Link to item Cite

Genomic tests for ovarian cancer detection and management.

Journal Article Evid Rep Technol Assess (Full Rep) · October 2006 OBJECTIVES: To assess the evidence that the use of genomic tests for ovarian cancer screening, diagnosis, and treatment leads to improved outcomes. DATA SOURCES: PubMed and reference lists of recent reviews. REVIEW METHODS: We evaluated tests for: (a) sing ... Link to item Cite

ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes.

Journal Article Ann Surg Oncol · October 2006 BACKGROUND: A significant portion of cancers are accounted for by a heritable component, which has increasingly been linked to mutations in specific genes. Clinical interventions have been formulated for mutation carriers within affected families. The prim ... Full text Link to item Cite

Targeted bio weapons in the war against gynecologic cancers

Journal Article Contemporary Ob/Gyn · October 1, 2006 Will biological warfare revolutionize the battle against gynecologic cancers? Two experts share the latest molecular tactics using "special" agents. Lethal weapons like Herceptin can throw up some roadblocks, even when they can't always destroy a tumor. ... Cite

Pelvic lymph node count is an important prognostic variable for FIGO stage I and II endometrial carcinoma with high-risk histology.

Journal Article Gynecol Oncol · July 2006 OBJECTIVE: To determine whether pelvic lymph node count is associated with patterns of recurrence or survival in patients with FIGO stage I and II endometrial cancer. METHODS: Single institution retrospective study of 467 patients with FIGO stage I and II ... Full text Link to item Cite

A comparison of combination docetaxel/carboplatin versus sequential docetaxel then carboplatin in patients with recurrent platinum-sensitive ovarian cancer.

Journal Article J Clin Oncol · June 20, 2006 5092 Background: Combination paclitaxel and platinum-based chemotherapy has been shown to improve survival in patients with recurrent platinum-sensitive ovarian cancer. However, the incidence of neurotoxicity was significantly greater with combination ther ... Link to item Cite

A multi-institutional evaluation of the safety and efficacy of bevacizumab for recurrent, platinum-resistant ovarian cancer.

Journal Article J Clin Oncol · June 20, 2006 5019 Background: Bevacizumab has shown activity in recurrent ovarian cancer with an acceptable adverse event profile. However, the incidence of bowel perforation in a recent trial of heavily pretreated ovarian cancer patients was higher than expected from ... Link to item Cite

Maspin expression in epithelial ovarian cancer and associations with poor prognosis: a Gynecologic Oncology Group study.

Journal Article Gynecol Oncol · June 2006 OBJECTIVE: This study examined MASPIN expression in human ovarian cancer, and explored the association between MASPIN and prognosis in patients with advanced stage disease treated with first-line cisplatin, carboplatin and/or paclitaxel. METHODS: Frozen pr ... Full text Link to item Cite

The granulin-epithelin precursor is a steroid-regulated growth factor in endometrial cancer.

Journal Article J Soc Gynecol Investig · May 2006 OBJECTIVES: The majority of endometrial cancers arise as a result of estrogen stimulation, the molecular targets of which remain incompletely defined. We hypothesize that the granulin-epithelin precursor (GEP) may be one such target. In this study, we exam ... Full text Link to item Cite

YY1 imprint status and role in ovarian carcinogenesis

Conference CANCER RESEARCH · April 1, 2006 Link to item Cite

Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer.

Journal Article Mol Cancer Res · April 2006 Overexpression of the imprinted insulin-like growth factor-II (IGF2) is a prominent characteristic of gynecologic malignancies. The purpose of this study was to determine whether IGF2 loss of imprinting (LOI), aberrant H19 expression, and/or epigenetic der ... Full text Link to item Cite

Intra-peritoneal cisplatin and whole abdomen hyperthermia for relapsed ovarian carcinoma.

Journal Article Int J Hyperthermia · March 2006 The study was designed to determine the maximum tolerated dose (MTD) of IP cisplatin [CDDP] combined with intravenous thiosulphate and concurrent whole abdomen hyperthermia for advanced, recurrent or progressive ovarian carcinoma. Between September 1991 an ... Full text Link to item Cite

Oncogenic pathway signatures in human cancers as a guide to targeted therapies.

Journal Article Nature · January 19, 2006 Featured Publication The development of an oncogenic state is a complex process involving the accumulation of multiple independent mutations that lead to deregulation of cell signalling pathways central to the control of cell growth and cell fate. The ability to define cancer ... Full text Link to item Cite

Use of trastuzumab in the treatment of metastatic endometrial cancer.

Journal Article Int J Gynecol Cancer · 2006 Featured Publication Systemic therapy of metastatic endometrial cancer is relatively ineffective. Response rates to chemotherapy and hormonal therapy in published studies range from 11% to 57%, but most responses are partial and of limited duration. In this case, we present a ... Full text Link to item Cite

High throughput detection of M6P/IGF2R intronic hypermethylation and LOH in ovarian cancer.

Journal Article Nucleic Acids Res · 2006 Cell surface mannose 6-phosphate/insulin-like growth factor II receptors (M6P/IGF2R) bind and target exogenous insulin-like growth factor II (IGF2) to the prelysosomes where it is degraded. Loss of heterozygosity (LOH) for M6P/IGF2R is found in cancers, wi ... Full text Link to item Cite

Analgesic drug use and risk of ovarian cancer.

Journal Article Epidemiology · January 2006 Featured Publication BACKGROUND: Previous epidemiologic research suggests that analgesic use may reduce the risk of ovarian cancer, although results are not consistent. METHODS: In a population-based, case-control study, we analyzed data from 586 ovarian cancer cases and 627 m ... Full text Link to item Cite

High expression of insulin-like growth factor binding protein-2 messenger RNA in epithelial ovarian cancers produces elevated preoperative serum levels.

Journal Article Int J Gynecol Cancer · 2006 The molecular etiology of epithelial ovarian cancer remains unclear. Using microarray expression analysis, we recently reported that expression of the insulin-like growth factor binding protein-2 (IGFBP-2) gene is elevated in advanced epithelial ovarian ca ... Full text Link to item Cite

Gene expression analysis of tumor infiltrating lymphocyte markers in endometrial cancers indicates no significant increases in those cases with microsatellite instability.

Journal Article Cancer Biomark · 2006 Microsatellite instability (MSI) is seen in many cancers and is the result of either a germline or somatic defect in the DNA mismatch repair system. Microsatellite instability is common in endometrial cancers occurring in about 25% of cases with endometrio ... Full text Link to item Cite

Prediction of lymph node metastasis in patients with endometrioid endometrial cancer using expression microarray.

Journal Article Clin Cancer Res · January 1, 2006 PURPOSE: To characterize the gene expression profiles of endometrioid endometrial cancers associated with lymph node metastasis in an effort to identify genes associated with metastatic spread. EXPERIMENTAL DESIGN: Tumors from 41 patients with endometrioid ... Full text Link to item Cite

Identification of genes associated with ovarian cancer metastasis using microarray expression analysis.

Journal Article Int J Gynecol Cancer · 2006 Although the transition from early- to advanced-stage ovarian cancer is a critical determinant of survival, little is known about the molecular underpinnings of ovarian metastasis. We hypothesize that microarray analysis of global gene expression patterns ... Full text Link to item Cite

Resection of lymph node metastases influences survival in stage IIIC endometrial cancer.

Journal Article Gynecol Oncol · December 2005 OBJECTIVE: Surgical staging of endometrial cancer identifies those patients with microscopic metastatic disease most likely to benefit from adjuvant therapy and may also confer therapeutic benefit. Our objective was to compare survival of patients who unde ... Full text Link to item Cite

Oncogenic pathway signatures in human cancers as a guide to targeted therapies.

Conference CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION · November 1, 2005 Link to item Cite

Anthropometric measurements and epithelial ovarian cancer risk in African-American and White women.

Journal Article Cancer Causes Control · October 2005 Previous studies of anthropometric factors and ovarian cancer risk have been inconsistent and none have evaluated the association among African-American women. Data from a population-based, case-control study of 593 cases and 628 controls were used to eval ... Full text Link to item Cite

Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon.

Journal Article Clin Cancer Res · September 1, 2005 PURPOSE: Epithelial ovarian cancers are thought to arise from flattened epithelial cells that cover the ovarian surface or that line inclusion cysts. During malignant transformation, different histotypes arise that resemble epithelial cells from normal fal ... Full text Link to item Cite

Menopausal hormones and risk of ovarian cancer.

Journal Article Am J Obstet Gynecol · July 2005 OBJECTIVE: The objective of this study was to determine if use of menopausal hormones was associated with ovarian cancer and if risk varied by type of hormone used. STUDY DESIGN: Data from a population-based, case-control study of ovarian cancer in North C ... Full text Link to item Cite

Gene expression profiling of microsatellite unstable and microsatellite stable endometrial cancers indicates distinct pathways of aberrant signaling.

Journal Article Cancer Res · June 15, 2005 Microsatellite instability (MSI) is a molecular phenotype present in approximately 25% of endometrial cancers. We examined the global gene expression profiles of early-stage endometrioid endometrial cancers with and without the MSI phenotype to test the hy ... Full text Link to item Cite

Expression analysis of genes involved in ovarian cancer metastasis.

Journal Article J Clin Oncol · June 2005 5038 Background: Epithelial ovarian cancer is the most lethal gynecologic malignancy. Patients with early stage ovarian cancer have an excellent prognosis, in contrast to patients with advanced stage disease, who have a 5-year survival of less than 30%. Al ... Link to item Cite

Retrospective analysis of selective lymphadenectomy in apparent early-stage endometrial cancer.

Journal Article J Clin Oncol · June 1, 2005 Featured Publication PURPOSE: Selective lymphadenectomy is widely accepted in the management of endometrial cancer. Purported benefits are individualization of adjuvant therapy based on extent of disease and resection of occult metastases. Our goal was to assess effects of the ... Full text Link to item Cite

Phase I/II trial of intravenous Doxil and whole abdomen hyperthermia in patients with refractory ovarian cancer.

Journal Article Int J Hyperthermia · June 2005 OBJECTIVE: A phase I/II study of Doxil combined with whole abdomen hyperthermia was conducted in patients with refractory ovarian cancer. Liposomal doxorubicin combined with hyperthermia has been shown to increase both liposomal delivery and drug extravasa ... Full text Link to item Cite

BRAF polymorphisms and the risk of ovarian cancer of low malignant potential.

Journal Article Gynecol Oncol · June 2005 OBJECTIVE: The object of this study was to test the hypothesis that BRAF is a low-risk susceptibility gene for low malignant potential (LMP) ovarian cancer. A recent study of the relationship between BRAF polymorphisms and malignant melanoma identified str ... Full text Link to item Cite

Microarray analysis of endometrial carcinomas and mixed mullerian tumors reveals distinct gene expression profiles associated with different histologic types of uterine cancer.

Journal Article Clin Cancer Res · June 1, 2005 Previous studies using cDNA microarray have indicated that distinct gene expression profiles characterize endometrioid and papillary serous carcinomas of the endometrium. Molecular studies have observed that mixed mullerian tumors, characterized by both ca ... Full text Link to item Cite

Expression analysis of genes involved in ovarian cancer metastasis.

Conference JOURNAL OF CLINICAL ONCOLOGY · June 1, 2005 Link to item Cite

Patterns of gene expression that characterize long-term survival in advanced stage serous ovarian cancers.

Journal Article Clin Cancer Res · May 15, 2005 Featured Publication PURPOSE: A better understanding of the underlying biology of invasive serous ovarian cancer is critical for the development of early detection strategies and new therapeutics. The objective of this study was to define gene expression patterns associated wi ... Full text Link to item Cite

Rectus abdominis myocutaneous and myoperitoneal flaps for neovaginal reconstruction after radical pelvic surgery: comparison of flap-related morbidity.

Journal Article Gynecol Oncol · May 2005 PURPOSE: To compare flap-specific complications of rectus abdominis myocutaneous (RAM) and myoperitoneal (RAMP) flap neovagina reconstructions performed concurrently with radical pelvic procedures. MATERIALS AND METHODS: Retrospective single institution ch ... Full text Link to item Cite

Transforming growth factor beta receptor I polyalanine repeat polymorphism does not increase ovarian cancer risk.

Journal Article Gynecol Oncol · May 2005 Featured Publication OBJECTIVES: It has been suggested that the 6A allele of the type I TGFbeta receptor (TGFbetaR1) polyalanine repeat tract polymorphism may increase susceptibility to various types of cancer including ovarian cancer. METHODS: The TGFbetaR1 polyalanine polymo ... Full text Link to item Cite

Antidepressant medication use [corrected] and risk of ovarian cancer.

Journal Article Obstet Gynecol · April 2005 OBJECTIVE: It has been hypothesized that antidepressants may enhance cancer growth. Previous studies of antidepressant use and ovarian cancer have been inconsistent and have been limited in their ability to examine the association with selective serotonin ... Full text Link to item Cite

High insulin-like growth factor-2 (IGF-2) gene expression is an independent predictor of poor survival for patients with advanced stage serous epithelial ovarian cancer.

Journal Article Gynecol Oncol · February 2005 OBJECTIVE: Epithelial ovarian cancer is the deadliest gynecologic malignancy, yet its molecular etiology remains poorly understood. Evidence is accumulating to support a role for the insulin-like growth factor family in human carcinogenesis, and recently u ... Full text Link to item Cite

Flushing and papules in a middle-aged woman.

Journal Article Obstet Gynecol · February 2005 Full text Link to item Cite

Preface

Book · January 1, 2005 Cite

The molecular genetics of endometrial cancer

Chapter · January 1, 2005 Endometrial cancer is the most common gynecological malignancy in the United States. It is the fourth most common cancer in females, and the seventh leading cause of cancer-related deaths. The American Cancer Society estimates that 39,300 cases occured in ... Cite

Uterine cancer

Book · January 1, 2005 This authoritative reference compiles the latest studies on the epidemiology, diagnosis, and treatment of uterine cancer and offers an extensive review of the molecular pathogenesis of endometrial and uterine disorders-analyzing patterns of disease present ... Cite

Rectus abdominis myocutaneous flaps for neovaginal reconstruction after radical pelvic surgery.

Journal Article Int J Gynecol Cancer · 2005 The objective of this article is to compare the flap-specific complications associated with vertical (VRAM) and transverse (TRAM) rectus abdominis myocutaneous flap vaginal reconstructions performed during radical pelvic procedures. A retrospective chart r ... Full text Link to item Cite

Progesterone receptor promoter +331A polymorphism is associated with a reduced risk of endometrioid and clear cell ovarian cancers.

Journal Article Cancer Epidemiol Biomarkers Prev · December 2004 Featured Publication OBJECTIVE: The progestagenic milieu of pregnancy and oral contraceptive use is protective against epithelial ovarian cancer. A functional single nucleotide polymorphism in the promoter of the progesterone receptor (+331A) alters the relative abundance of t ... Link to item Cite

Stretching the surface epithelium.

Journal Article J Soc Gynecol Investig · December 2004 Full text Link to item Cite

Trinucleotide repeat polymorphisms in the androgen receptor gene and risk of ovarian cancer.

Conference CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION · November 1, 2004 Link to item Cite

Preoperative sensitivity and specificity for early-stage ovarian cancer when combining cancer antigen CA-125II, CA 15-3, CA 72-4, and macrophage colony-stimulating factor using mixtures of multivariate normal distributions.

Journal Article J Clin Oncol · October 15, 2004 PURPOSE: In CA-125-based ovarian cancer screening trials, overall specificity and screening sensitivity of ultrasound after an elevated CA-125 exceeded 99.6% and 70%, respectively, thereby yielding a positive predictive value (PPV) exceeding 10%. However, ... Full text Link to item Cite

Serum proteomics yield new biomarkers for ovarian cancer

Journal Article Cancer Biology and Therapy · September 1, 2004 Cite

Three biomarkers identified from serum proteomic analysis for the detection of early stage ovarian cancer.

Journal Article Cancer Res · August 15, 2004 Early detection remains the most promising approach to improve long-term survival of patients with ovarian cancer. In a five-center case-control study, serum proteomic expressions were analyzed on 153 patients with invasive epithelial ovarian cancer, 42 wi ... Full text Link to item Cite

Phase I/II trial of intravenous liposomal doxorubicin and whole abdomen hyperthermia in patients with refractory ovarian cancer.

Journal Article J Clin Oncol · July 15, 2004 5089 Background: A phase I/II study of liposomal doxorubicin combined with whole abdominal hyperthermia was conducted in patients with refractory ovarian cancer. Liposomal doxorubicin combined with hyperthermia has been shown to increase liposomal extravas ... Link to item Cite

Phase I/II trial of combination topotecan and vinorelbine in patients with refractory gynecologic cancer.

Journal Article J Clin Oncol · July 15, 2004 5152 Background: Topotecan (T) and vinorelbine (V) have shown efficacy in recurrent ovarian and cervical cancer. The purpose of this trial was to determine the recommended dose of combination T and V and to assess its efficacy in patients with refractory g ... Link to item Cite

Intraperitoneal cisplatin and whole abdomen hyperthermia for relapsed ovarian carcinoma.

Journal Article J Clin Oncol · July 15, 2004 5038 Background:The study was designed to determine the maximum tolerated dose (MTD) of intraperitoneal cisplatin [CDDP] combined with intravenous thiosulfate and concurrent whole abdomen hyperthermia for advanced, recurrent or progressive ovarian carcinom ... Link to item Cite

The relationship between serum vascular endothelial growth factor, persistent disease, and survival at second-look laparotomy in ovarian cancer.

Journal Article Gynecol Oncol · July 2004 OBJECTIVE: To assess if the angiogenic factors vascular endothelial growth factor (VEGF) and D-dimer are predictive of persistent disease, early relapse, and survival in patients with ovarian cancer who achieve a complete clinical remission after first-lin ... Full text Link to item Cite

Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis.

Journal Article Clin Cancer Res · May 15, 2004 PURPOSE: Advanced-stage epithelial ovarian cancer has a poor prognosis with long-term survival in less than 30% of patients. When the disease is detected in stage I, more than 90% of patients can be cured by conventional therapy. Screening for early-stage ... Full text Link to item Cite

The selective estrogen receptor modulator arzoxifene and the rexinoid LG100268 cooperate to promote transforming growth factor beta-dependent apoptosis in breast cancer.

Journal Article Cancer Res · May 15, 2004 We show that the selective estrogen receptor modulator arzoxifene (Arz) and the rexinoid LG100268 (268) synergize to promote apoptosis in a rat model of estrogen receptor-positive breast carcinoma and in estrogen receptor-positive human breast cancer cells ... Full text Link to item Cite

Prediction of optimal versus suboptimal cytoreduction of advanced-stage serous ovarian cancer with the use of microarrays.

Journal Article Am J Obstet Gynecol · April 2004 OBJECTIVE: The purpose of this study was to define gene expression patterns that are associated with the optimal versus suboptimal debulking of advanced-stage serous ovarian cancers. STUDY DESIGN: RNA from 44 advanced serous ovarian cancers (19 optimal, 25 ... Full text Link to item Cite

Gene expression patterns that characterize advanced stage serous ovarian cancers.

Journal Article J Soc Gynecol Investig · January 2004 OBJECTIVE: To identify gene expression patterns that characterize advanced stage serous ovarian cancers by using microarray expression analysis. METHODS: Using genome-wide expression analysis, we compared a series of 31 advanced stage (III or IV) serous ov ... Full text Link to item Cite

What caused this woman's 'myoma'?

Journal Article Contemporary Ob/Gyn · December 1, 2003 Cite

Abdominal pain and bloating in two 20-something patients

Journal Article Contemporary Ob/Gyn · December 1, 2003 Cite

Prognostic significance of p53 mutation and p53 overexpression in advanced epithelial ovarian cancer: a Gynecologic Oncology Group Study.

Journal Article J Clin Oncol · October 15, 2003 Featured Publication PURPOSE: The prognostic significance of p53 mutations and overexpression in advanced epithelial ovarian cancers was examined in primary tumors from 125 patients participating in a Gynecologic Oncology Group randomized phase III treatment protocol. PATIENTS ... Full text Link to item Cite

Polymorphisms in BRCA1 and BRCA2 and risk of epithelial ovarian cancer.

Journal Article Clin Cancer Res · October 1, 2003 PURPOSE: Because inherited BRCA1 or BRCA2 mutations strikingly increase ovarian cancer risk, polymorphisms in these genes could represent low penetrance susceptibility alleles. Previous studies of the BRCA2 N372H polymorphism suggested that HH homozygotes ... Link to item Cite

Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer

Journal Article Clinical Cancer Research · October 1, 2003 The levels of lysophosphatidic acid (LPA) are consistently elevated in the ascites of ovarian cancer patients, suggesting that ovarian cancer cells are exposed to an LPA replete environment. LPA stimulates cell proliferation, cell survival, resistance to c ... Cite

Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer.

Journal Article Clin Cancer Res · September 1, 2003 The levels of lysophosphatidic acid (LPA) are consistently elevated in the ascites of ovarian cancer patients, suggesting that ovarian cancer cells are exposed to an LPA replete environment. LPA stimulates cell proliferation, cell survival, resistance to c ... Link to item Cite

Matrix metalloproteinase-1 gene promoter polymorphism and risk of ovarian cancer.

Journal Article J Soc Gynecol Investig · September 2003 OBJECTIVE: It has been suggested that the 2G allele of a guanine insertion-deletion promoter polymorphism in the promoter of the matrix metalloproteinase-1 (MMP1) gene may increase susceptibility to ovarian cancer. The 2G allele also has been associated wi ... Full text Link to item Cite

Predictors of clinical outcomes in the laparoscopic management of adnexal masses.

Journal Article Obstet Gynecol · August 2003 OBJECTIVE: Laparoscopy has become an accepted approach in the management of adnexal masses. We evaluated clinical outcomes of laparoscopic management of adnexal masses thought to be benign preoperatively. METHODS: We performed a retrospective study of pati ... Full text Link to item Cite

A pilot Phase II trial of concurrent radiotherapy, chemotherapy, and hyperthermia for locally advanced cervical carcinoma.

Journal Article Cancer · July 15, 2003 BACKGROUND: Five randomized studies have demonstrated a benefit derived from adding cisplatin (CDDP)-based chemotherapy to radiotherapy (RT) for treatment of cervical carcinoma. The Dutch Phase III pelvic tumor trial demonstrated a survival and local contr ... Full text Link to item Cite

Characterization of prediagnostic symptoms among primary epithelial ovarian cancer cases and controls.

Journal Article Gynecol Oncol · July 2003 OBJECTIVE: The goal of this study was to characterize types, frequency, combinations, and relative onset of symptoms among ovarian cancer cases and controls. METHODS: Participants were from an ongoing, population-based, case-control study of primary epithe ... Full text Link to item Cite

The role of PET scanning in the detection of recurrent cervical cancer.

Journal Article Gynecol Oncol · July 2003 OBJECTIVES: [(18)F] Fluoro-2-deoxyglucose positron emission tomography (FDG PET) has recently been established as a sensitive and specific method of detecting lymph node metastases in newly diagnosed cervical cancer. Little is known about the efficacy of P ... Full text Link to item Cite

Promoter hypermethylation as an epigenetic component in Type I and Type II endometrial cancers.

Journal Article Ann N Y Acad Sci · March 2003 Epigenetic mechanisms that result in aberrant gene expression are a prominent feature of many cancer types. One main epigenetic mechanism for gene silencing involves promoter hypermethylation. Type I and type II endometrial cancers exhibit differing clinic ... Full text Link to item Cite

Galectin-1 accumulation in the ovary carcinoma peritumoral stroma is induced by ovary carcinoma cells and affects both cancer cell proliferation and adhesion to laminin-1 and fibronectin.

Journal Article Lab Invest · March 2003 Galectin-1 (gal-1) is a 14-kDa laminin-binding galectin involved in several biologic events including regulation of cancer cell proliferation and adhesion to the matrix. In this study, we examined gal-1 expression in 30 human epithelial ovary carcinoma sam ... Full text Link to item Cite

High expression of tumor necrosis factor-related apoptosis-inducing ligand is associated with favorable ovarian cancer survival.

Journal Article Clin Cancer Res · February 2003 PURPOSE: The molecular determinants of survival in ovarian cancer are poorly understood. Using expression microarrays, we recently found that high expression of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene is associated with pro ... Link to item Cite

The Genetic Etiology of Sporadic Ovarian Cancer

Journal Article · January 1, 2003 Epithelial ovarian cancer is known to be the deadliest gynecologic malignancy and is a leading cause of cancer death in women. Genetic alterations disrupt regulation of proliferation, programmed cell death, and senescence thus causing malignant transformat ... Full text Cite

Microarray analysis reveals distinct gene expression profiles among different histologic types of endometrial cancer.

Journal Article Cancer Res · January 1, 2003 Previous studies of oncogene and tumor suppressor gene alterations have suggested that differences exist in the molecular pathogenesis of the various histological types of endometrial cancer. To elucidate further the molecular events involved in endometria ... Link to item Cite

Weekly low-dose carboplatin and paclitaxel in the treatment of recurrent ovarian and peritoneal cancer.

Journal Article Gynecol Oncol · January 2003 OBJECTIVES: Weekly paclitaxel alone has moderate activity in the salvage treatment of recurrent ovarian cancer and is associated with a favorable toxicity profile. Combination paclitaxel and carboplatin is a well-established first-line regimen for ovarian ... Full text Link to item Cite

Discussion: Ovarian Cancer Prevention

Conference Gynecologic Oncology · January 2003 Full text Cite

Ovulation and ovarian cancer: a comparison of two methods for calculating lifetime ovulatory cycles (United States).

Journal Article Cancer Causes Control · November 2002 OBJECTIVE: To compare two methods for calculating lifetime ovulatory cycles (LOC) to determine if more detailed menstrual cycle information results in stronger associations with ovarian cancer. METHODS: Using data from 232 cases and 242 controls in a popul ... Full text Link to item Cite

Evaluation of ovarian cancer preventive agents in the chicken.

Conference CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION · October 1, 2002 Link to item Cite

A case-control study of candidate ovarian cancer susceptibility polymorphisms.

Conference CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION · October 1, 2002 Link to item Cite

Molecular aspects of ovarian cancer.

Journal Article Best Pract Res Clin Obstet Gynaecol · August 2002 Ovarian cancer is caused by genetic alterations that disrupt proliferation, apoptosis, senescence and DNA repair. Approximately 10% of ovarian cancers arise in women who have inherited mutations in cancer susceptibility genes (BRCA1 or BRCA2). The ability ... Full text Link to item Cite

Cell proliferation and apoptosis in human uterine leiomyomas and myometria.

Journal Article Virchows Arch · July 2002 To determine the role of cell proliferation and apoptosis in uterine leiomyoma growth, we studied protein expression of two major regulatory proteins of apoptosis -- Bcl-2 (anti-apoptotic) and Bax (pro-apoptotic) -- and two endogenous markers of cell repli ... Full text Link to item Cite

The molecular biology of Sertoli-Leydig cell tumors of the ovary

Journal Article CME Journal of Gynecologic Oncology · July 1, 2002 Sertoli-Leydig tumors are infrequent neoplasms of the ovary that often have androgenic and estrogenic clinical effects. Production of these hormones occurs within both the Sertoli and Leydig cells and can be influenced by other steroid and peptide hormones ... Cite

Progestin-induced apoptosis in the Macaque ovarian epithelium: differential regulation of transforming growth factor-beta.

Journal Article J Natl Cancer Inst · January 2, 2002 BACKGROUND: Oral contraceptive (OC) use is associated with a reduced risk of ovarian cancer. An OC component, progestin, induces apoptosis in the primate ovarian epithelium. One regulator of apoptosis is transforming growth factor-beta (TGF-beta). We deter ... Full text Link to item Cite

Loss of expression of the p16 tumor suppressor gene is more frequent in advanced ovarian cancers lacking p53 mutations.

Journal Article Gynecol Oncol · December 2001 OBJECTIVE: The aim of this study was to test the hypothesis that p53 mutations are less frequent in ovarian cancers with alterations in other genes that regulate G1 progression. METHODS: Expression of G1 stimulatory (cyclins D1 and E, cdk4, Ki67) and inhib ... Full text Link to item Cite

OVX1, macrophage-colony stimulating factor, and CA-125-II as tumor markers for epithelial ovarian carcinoma: a critical appraisal.

Journal Article Cancer · December 1, 2001 BACKGROUND: Ovarian carcinoma remains the leading cause of death from gynecologic malignancy in Australia, the Netherlands, and the United States. CA-125-II, the most widely used serum marker, has limited sensitivity and specificity for detecting small-vol ... Full text Link to item Cite

Types and duration of symptoms prior to diagnosis of invasive or borderline ovarian tumor.

Journal Article Gynecol Oncol · December 2001 OBJECTIVE: The objective was to describe and compare types and duration of symptoms among women with invasive versus borderline ovarian tumors. METHODS: Cases were women, ages 20-69 years, diagnosed with invasive (616) and borderline (151) epithelial ovari ... Full text Link to item Cite

Mycobacterium bovis peritonitis mimicking ovarian cancer in a young woman.

Journal Article Clin Infect Dis · August 15, 2001 We describe a 27-year-old woman with peritonitis due to Mycobacterium bovis that initially appeared to be ovarian cancer. Clinicians should include this disease in the differential diagnosis of ovarian cancer and should consider laparoscopic diagnosis in t ... Full text Link to item Cite

Allele loss on chromosome 1p36 in epithelial ovarian cancers.

Journal Article Gynecol Oncol · July 2001 OBJECTIVES: Prior studies have shown that allelic loss on chromosome 1p36 occurs frequently in ovarian as well as several other types of cancer. This suggests that inactivation of gene(s) in this region may play a role in the pathogenesis of these cancers. ... Full text Link to item Cite

Comparison of two methods for calculating lifetime ovulatory cycles.

Journal Article AMERICAN JOURNAL OF EPIDEMIOLOGY · June 1, 2001 Link to item Cite

Mutational analysis of the PTEN gene in human uterine sarcomas.

Journal Article Am J Obstet Gynecol · May 2001 OBJECTIVE: Uterine sarcomas are rare, lethal cancers, and little is known about their molecular etiology. The PTEN gene is located on chromosome 10q23.3, a region that displays frequent loss of heterozygosity in human uterine sarcomas. PTEN mutations have ... Full text Link to item Cite

Favorable survival associated with microsatellite instability in endometrioid endometrial cancers.

Journal Article Obstet Gynecol · March 2001 OBJECTIVE: To determine whether microsatellite instability in endometrioid endometrial cancer is associated with favorable survival. METHODS: Microsatellite instability analysis was performed in 131 patients with endometrioid endometrial cancer using three ... Full text Link to item Cite

K-ras mutations in Müllerian inclusion cysts associated with serous borderline tumors of the ovary.

Journal Article Gynecol Oncol · February 2001 OBJECTIVE: Müllerian inclusion cysts (MIC) are small benign appearing glands that are occasionally noted in lymph nodes and peritoneal biopsies. They occur most frequently in women with serous ovarian tumors, with borderline tumors (SBOT) having a higher i ... Full text Link to item Cite

Relationship between expression of coactivators and corepressors of hormone receptors and resistance of ovarian cancers to growth regulation by steroid hormones.

Journal Article J Soc Gynecol Investig · 2001 OBJECTIVE: To determine whether aberrant expression of hormone receptor corepressors or coactivators or defects in estrogen receptor-mediated transcription might underlie resistance of ovarian cancers to hormonal therapy. METHODS: Northern analysis, Wester ... Link to item Cite

An approach to analysis of large-scale correlations between genome changes and clinical endpoints in ovarian cancer.

Journal Article Cancer Res · October 1, 2000 This report describes analyses of associations of genome copy number abnormalities in ovarian cancers with clinical features using genome-wide graphical and analytical procedures. These studies show that tumor grade is a better indicator of the extent of g ... Link to item Cite

Racial disparity in the frequency of PTEN mutations, but not microsatellite instability, in advanced endometrial cancers.

Journal Article Clin Cancer Res · August 2000 Survival of African Americans with endometrial cancer is significantly worse than that of whites. Mutation of the PTEN tumor suppressor gene and microsatellite instability occur in some endometrial cancers, and they are associated with favorable prognostic ... Link to item Cite

ARHI is the center of allelic deletion on chromosome 1p31 in ovarian and breast cancers.

Journal Article Int J Cancer · June 1, 2000 In our previous work, we had characterized ARHI as an imprinted putative tumor-suppressor gene in ovarian and breast cancers. ARHI is expressed in primary breast and ovarian cell lines but largely absent from the corresponding malignant tumors. Moreover, t ... Full text Link to item Cite

Some mullerian inclusion cysts in lymph nodes may sometimes be metastases from serous borderline tumors of the ovary.

Journal Article Am J Surg Pathol · May 2000 Glandular inclusions that appear morphologically benign are occasionally found in lymph nodes as well as in peritoneal and omental biopsies. In patients with gynecologic malignancies, the nature and significance of these mullerian inclusion cysts (MIC) pre ... Full text Link to item Cite

Letter to the editor.

Journal Article Gynecol Oncol · January 2000 Full text Link to item Cite

Comparative genomic hybridization studies in hydatidiform moles and choriocarcinoma: amplification of 7q21-q31 and loss of 8p12-p21 in choriocarcinoma.

Journal Article Cancer Genet Cytogenet · January 1, 2000 Comparative genomic hybridization (CGH) was utilized to investigate genetic changes from archived cases of choriocarcinoma (n = 12) and hydatidiform moles (n = 7). Test DNA was extracted from paraffin-embedded tissues, amplified using total universal PCR, ... Full text Link to item Cite

Prognostic factors in early-onset epithelial ovarian cancer: a population-based study.

Journal Article Obstet Gynecol · January 2000 OBJECTIVE: To investigate the clinical prognostic factors that influence ovarian cancer survival in women with early-onset epithelial ovarian cancer using population-based data. METHODS: Subjects in the current study were from a population-based series of ... Full text Link to item Cite

Managing hereditary ovarian cancer risk.

Journal Article Cancer · December 1, 1999 Ovarian cancer is the fourth leading cause of cancer deaths in American women. About 10% of cases are thought to have a hereditary basis, and family history is the strongest known risk factor. In the past, prophylactic oophorectomy has been advocated for w ... Full text Link to item Cite

Relationship between alterations in the p53 tumor suppressor gene and prognosis of ovarian cancer

Journal Article CME Journal of Gynecologic Oncology · December 1, 1999 Mutation and overexpression of the p53 tumor suppressor gene are the most frequently described genetic alterations noted thus far in epithelial ovarian cancers; and it is thought that loss of p53 tumor suppressor function plays a significant role in the pa ... Cite

Relationship between alterations in the p53 gene and chemosensitivity of ovarian cancers

Other CME Journal of Gynecologic Oncology · December 1, 1999 It is thought that the cytotoxic effect of chemotherapy drugs is largely due to their ability to initiate programmed cell death (apoptosis). Although the molecular pathways involved in regulation of apoptosis have not been completely elucidated, it has bee ... Cite

Somatic genetic events in BRCA1 and BRCA2-related ovarian cancer

Journal Article CME Journal of Gynecologic Oncology · December 1, 1999 An estimated 10% of all ovarian cancer cases are thought to be the result of an autosomal dominant susceptibility factor with high penetrance. Most of these cases can be attributed to germline mutations in the BRCA1 or BRCA2 tumor suppressor genes. It was ... Cite

Prognosis of BRCA1 and 2-associated ovarian cancers

Journal Article CME Journal of Gynecologic Oncology · December 1, 1999 About 10% of epithelial ovarian cancers have a hereditary basis. Germline mutations in the BRCA1 and BRCA2 breast/ovarian cancer susceptibility genes are thought to be responsible for most hereditary ovarian cancers. In contrast, about 90% of ovarian cance ... Cite

Managing hereditary ovarian cancer risk

Journal Article Cancer · October 15, 1999 Ovarian cancer is the fourth leading cause of cancer deaths in American women. About 10% of cases are thought to have a hereditary basis, and family history is the strongest known risk factor. In the past, prophylactic oophorectomy has been advocated for w ... Full text Cite

Cost-effectiveness of treatment of early stage endometrial cancer.

Journal Article Gynecol Oncol · August 1999 OBJECTIVE: The purpose of this study was to determine the average life-years gained and cost per life-year gained in treatment of early endometrial cancer. METHODS: We performed a decision analysis using statistical models for survival after treatment for ... Full text Link to item Cite

Allelic loss on chromosome arm 8p: analysis of sporadic epithelial ovarian tumors.

Journal Article Gynecol Oncol · July 1999 OBJECTIVE: Our objective was to determine the frequency of allelic loss at 8p21 in sporadic epithelial ovarian cancer. We recently described allelic loss at this locus in 7/9 ovarian cancers from patients with BRCA1 gene mutations. METHODS: We anonymously ... Full text Link to item Cite

Bcl10 is not a target for frequent mutation in human carcinomas.

Journal Article Br J Cancer · July 1999 The recently described Bcl10 gene has been suggested to be a major target gene for inactivation in a variety of human cancers. In order to further evaluate the role of this gene in human adult malignancies, we have analysed a series of carcinomas for mutat ... Full text Link to item Cite

Accumulation of p53 protein is frequent in ovarian cancers associated with BRCA1 and BRCA2 germline mutations.

Journal Article J Clin Pathol · May 1999 BACKGROUND: Mutations in the BRCA1 or BRCA2 genes are responsible for up to 95% of hereditary ovarian cancer cases. Both genes function as tumour suppressor genes, and development of a cancer is thought to require an accumulation of somatic genetic events ... Full text Link to item Cite

Combination of multiple serum markers using an artificial neural network to improve specificity in discriminating malignant from benign pelvic masses.

Journal Article Gynecol Oncol · April 1999 A panel of four selected tumor markers, CA 125 II, CA 72-4, CA 15-3, and lipid-associated sialic acid, was analyzed collectively using an artificial neural network (ANN) approach to differentiate malignant from benign pelvic masses. A dataset of 429 patien ... Full text Link to item Cite

Genetic susceptibility testing and prophylactic oophorectomy.

Journal Article Eur J Obstet Gynecol Reprod Biol · February 1999 About 10% of ovarian cancer cases are thought to have a hereditary basis and family history is the strongest risk factor for the development of this disease. In the past, prophylactic oophorectomy has been advocated for women with two or more affected firs ... Full text Link to item Cite

Allelotype analysis of uterine leiomyoma: localization of a potential tumor suppressor gene to a 4-cM region of chromosome 7q.

Journal Article Mol Carcinog · December 1998 Uterine leiomyoma is a benign smooth muscle tumor of the myometrium and is the most commonly encountered neoplasm in women of reproductive age. As for most benign tumors, the pathogenesis of leiomyoma remains obscure, especially at the molecular genetic le ... Full text Link to item Cite

PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics.

Journal Article Clin Cancer Res · December 1998 Mutation of the PTEN tumor suppressor gene is a frequent event in endometrial cancers. In other types of cancers, PTEN mutation has been associated with metastatic behavior and advanced stage. To examine the relationship between PTEN mutation and clinical ... Link to item Cite

Mutations in the PTEN tumor suppressor gene in cervical carcinomas

Journal Article International Journal of Gynecological Cancer · December 1, 1998 To elucidate further the molecular pathogenesis of cervical cancer we sought to determine whether mutations in the PTEN tumor suppressor gene are a feature of these cancers. Genomic DNA was extracted from 67 primary cervical cancers and 9 immortalized cerv ... Full text Cite

Frequency of germline and somatic BRCA1 mutations in ovarian cancer.

Journal Article Clin Cancer Res · October 1998 Germline mutations in the BRCA1 tumor suppressor gene are thought to be the most common cause of hereditary ovarian cancer. The aim of this study was to explore further the role of BRCA1 alterations in the development of ovarian cancers. We sought to deter ... Link to item Cite

Coexpression of the HER-2 gene product, p185HER-2, and epidermal growth factor receptor, p170EGF-R, on epithelial ovarian cancers and normal tissues.

Journal Article Hybridoma · August 1998 Monoclonal antibodies (MAbs) and immunoconjugates reactive with different antigens expressed by neoplastic cells can inhibit tumor growth. Use of these agents in combination with one another or with chemotherapy can exert additive or synergistic cytotoxici ... Full text Link to item Cite

Suppression of diacylglycerol levels by antibodies reactive with the c-erbB-2 (HER-2/neu) gene product p185c-erbB-2 in breast and ovarian cancer cell lines.

Journal Article Gynecol Oncol · July 1998 Seven of 10 murine monoclonal antibodies reactive with the extracellular domain of p185c-erbB-2 inhibited the anchorage independent growth of the SKBr3 breast cancer cell line that overexpressed p185c-erbB-2. Significant inhibition (56-72%) of diacylglycer ... Full text Link to item Cite

Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancers.

Journal Article Gynecol Oncol · July 1998 OBJECTIVE: The PTEN tumor suppressor gene on chromosome 10q23 undergoes inactivating mutations in several types of malignancies including glioblastomas and prostate and endometrial carcinomas. The aim of this study was to determine if mutation of the PTEN ... Full text Link to item Cite

Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias.

Journal Article Cancer Res · June 15, 1998 Mutation and deletion of the PTEN tumor suppressor gene occurs in about 40% of endometrial carcinomas. The purpose of this study was to determine whether PTEN mutations also are present in endometrial hyperplasias, which are premalignant precursors of inva ... Link to item Cite

Aberrant splicing of the TSG101 tumor suppressor gene in human breast and ovarian cancers.

Journal Article J Soc Gynecol Investig · 1998 OBJECTIVE: To determine whether large deletions or other alterations in the putative tumor suppressor gene TSG101 play a role in the molecular pathogenesis of breast and ovarian cancers. METHODS: Expression of TSG101 transcripts was examined in breast and ... Full text Link to item Cite

Prognostic value of MIB-1 in advanced ovarian carcinoma as determined using automated immunohistochemistry and quantitative image analysis.

Journal Article J Surg Oncol · December 1997 BACKGROUND AND OBJECTIVES: The monoclonal antibody MIB-1 is an immunohistochemical marker reacting most strongly with cells in late S phase, G2, and M portions of the cell cycle. This antibody, reactive in formalin-fixed, paraffin-embedded tissue, allows t ... Full text Link to item Cite

Response

Journal Article JNCI Journal of the National Cancer Institute · November 19, 1997 Full text Cite

PTEN/MMAC1 mutations in endometrial cancers.

Journal Article Cancer Res · November 1, 1997 Endometrial carcinomas represent the most common gynecological cancer in the United States, yet the molecular genetic events that underlie the development of these tumors remain obscure. Chromosome 10 is implicated in the pathogenesis of endometrial carcin ... Link to item Cite

Loss of heterozygosity at chromosome segment Xq25-26.1 in advanced human ovarian carcinomas.

Journal Article Genes Chromosomes Cancer · November 1997 To determine whether a tumor suppressor gene of importance to epithelial ovarian cancer resides on the X chromosome, we examined loss of heterozygosity (LOH) in 123 epithelial ovarian cancer cases. In 54 such cases, we examined LOH at 26 loci on the human ... Link to item Cite

Human ovarian cancer of the surface epithelium.

Journal Article Biochem Pharmacol · September 1, 1997 Epidemiologic studies have shown that the risk of cancer in the ovarian surface epithelium is decreased by factors that suppress ovulation, whereas uninterrupted ovulation has been associated with increased risk. This suggests that ovulation may play a cri ... Full text Link to item Cite

Analysis of genetic alterations in uterine leiomyomas and leiomyosarcomas by comparative genomic hybridization.

Journal Article Mol Carcinog · August 1997 Uterine leiomyomas are the most prevalent tumor type in women of reproductive age and are the most common reason for hysterectomies. Although uterine leiomyomas are considered to be benign, they are a major public health concern for women. In contrast, lei ... Full text Link to item Cite

Relationship between lifetime ovulatory cycles and overexpression of mutant p53 in epithelial ovarian cancer.

Journal Article J Natl Cancer Inst · July 2, 1997 BACKGROUND: Several lines of evidence have suggested a relationship between a woman's number of ovulatory cycles and the development of ovarian epithelial cancer. Repair of the ovarian surface after ovulation requires cellular proliferation, and spontaneou ... Full text Link to item Cite

Dideoxy fingerprinting assay for BRCA1 mutation analysis.

Journal Article Mol Carcinog · July 1997 Since the isolation of BRCA1, the familial breast/ovarian cancer predisposition gene, much effort has been invested in characterizing the mutation spectrum. The large size of the gene and the wide distribution of its more than 100 mutations has increased t ... Link to item Cite

Racial disparity in overexpression of the p53 tumor suppressor gene in stage I endometrial cancer.

Journal Article Am J Obstet Gynecol · June 1997 OBJECTIVE: This study was conducted to determine whether overexpression of the p53 tumor suppressor gene is associated with poor outcome in early-stage endometrial cancers and whether a racial difference in the frequency of p53 overexpression contributes t ... Full text Link to item Cite

Signet-ring cell carcinoma of the endometrium: a primary tumor masquerading as a metastasis.

Journal Article Int J Gynecol Pathol · April 1997 Extragenital metastases to the endometrium are unusual, but several histologic features have been suggested as highly suggestive or even pathognomonic for this diagnosis. We report an endometrial carcinoma with a prominent signet-ring cell morphology and a ... Full text Link to item Cite

Endometrial carcinoma and its precursors.

Journal Article Curr Ther Endocrinol Metab · 1997 Link to item Cite

Genetics of ovarian cancer

Journal Article Endocrinologist · January 1, 1997 Epithelial ovarian cancer occurs primarily in postmenopausal women, and most cases are thought to be due to acquired alterations in oncogenes and tumor suppressor genes. In contrast, approximately 5-10% of ovarian cancers arise in women who carry inherited ... Full text Cite

Clinical and pathological features of ovarian cancer in women with germ-line mutations of BRCA1.

Journal Article N Engl J Med · November 7, 1996 BACKGROUND: We tested the hypothesis that ovarian cancers associated with germ-line mutations of BRCA1 have distinct clinical and pathological features as compared with sporadic ovarian cancers. METHODS: We reviewed clinical and pathological data on patien ... Full text Link to item Cite

Microsomal epoxide hydrolase polymorphism as a risk factor for ovarian cancer.

Journal Article Mol Carcinog · November 1996 Microsomal epoxide hydrolase (EPHX) is one of many enzymes involved in the metabolism of endogenous and exogenous toxicants. Polymorphic forms of the human EPHX gene have been described that vary in enzymatic activity, and one, Tyr113His, has been associat ... Full text Link to item Cite

p53 overexpression in advanced-stage endometrial adenocarcinoma.

Journal Article Am J Obstet Gynecol · November 1996 OBJECTIVES: Mutation and overexpression of the p53 tumor suppressor gene in endometrial cancers are associated with advanced stage and poor survival. We sought to determine whether p53 overexpression is an independent variable predictive of poor prognosis ... Full text Link to item Cite

Expression of the 67-kD laminin receptor, galectin-1, and galectin-3 in advanced human uterine adenocarcinoma.

Journal Article Hum Pathol · November 1996 Alterations of tumor cell interactions with laminin, a basement membrane glycoprotein, are consistent features of the invasive and metastatic phenotype. Qualitative and quantitative changes in the expression of cell surface laminin-binding proteins have be ... Full text Link to item Cite

Cell cycle control of BRCA2.

Journal Article Cancer Res · October 15, 1996 Identifying the conditions and kinetics of the induction of BRCA2 gene expression may implicate roles for the function of the tumor suppressor gene. In this study, expression of BRCA2 mRNA is shown to be regulated by the cell cycle and associated with prol ... Link to item Cite

Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair.

Journal Article Nat Genet · September 1996 Many human tumours have length alterations in repetitive sequence elements. Although this microsatellite instability has been attributed to mutations in four DNA mismatch repair genes in hereditary nonpolyposis colorectal cancer (HNPCC) kindreds, many spor ... Full text Link to item Cite

Relationship between p21 expression and mutation of the p53 tumor suppressor gene in normal and malignant ovarian epithelial cells.

Journal Article Clin Cancer Res · September 1996 In many cell types, p53-mediated growth inhibition is dependent on induction of p21, which is an inhibitor of cyclin-dependent kinases that are required for cell cycle progression. Failure of mutant p53 proteins to transactivate p21 may lead to uncontrolle ... Link to item Cite

Role of BRCA1 mutation screening in the management of familial ovarian cancer.

Journal Article Am J Obstet Gynecol · September 1996 Families with multiple cases of ovarian cancer have long been observed, and in the past prophylactic oophorectomy has been advocated for women with a history of ovarian cancer in two first-degree relatives. It is now thought that > 90% of familial ovarian ... Full text Link to item Cite

Role of BRCA1 mutation screening in the management of familial ovarian cancer

Journal Article AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY · September 1, 1996 Link to item Cite

Mutational analysis of the p21/WAF1/CIP1/SDI1 coding region in human tumor cell lines.

Journal Article Mol Carcinog · August 1996 p21/WAF1/CIP1/SDI1 is an important cell-cycle mediator with tumor suppressor gene capabilities, and its inactivation could potentially lead to tumor progression. Because tumor suppressor genes are commonly inactivated by somatic and germline mutations, we ... Full text Link to item Cite

BRCA1 expression is induced before DNA synthesis in both normal and tumor-derived breast cells.

Journal Article Cell Growth Differ · June 1996 Insight into the function of the BRCA1 tumor suppressor gene may be gained by studying its regulation. In this study, the expression of BRCA1 was examined as a function of the cell cycle in normal and tumor-derived breast epithelial cells. Cells arrested i ... Link to item Cite

BRCA2 mutations in primary breast and ovarian cancers.

Journal Article Nat Genet · June 1996 The second hereditary breast cancer gene, BRCA2, was recently isolated. Germline mutations of this gene predispose carriers to breast cancer, and, to a lesser extent, ovarian cancer. Loss of heterozygosity (LOH) at the BRCA2 locus has been observed in 30-4 ... Full text Link to item Cite

Preoperative evaluation of macrophage colony-stimulating factor levels in patients with endometrial cancer.

Journal Article Am J Obstet Gynecol · April 1996 OBJECTIVE: Our purpose was to examine the relationship between preoperative serum levels of macrophage colony-stimulating factor, alone and in combination with CA 125, and the presence of prognostic clinicopathologic factors and subclinical metastases in w ... Full text Link to item Cite

An inevitable dilemma: prenatal testing for mutations in the BRCA1 breast-ovarian cancer susceptibility gene.

Journal Article Obstet Gynecol · February 1996 The BRCA1 breast-ovarian cancer susceptibility gene was identified recently. Germline mutations in BRCA1 may be responsible for as many as 5% of breast and ovarian cancers. Inherited alterations confer up to a 94% risk of developing breast and/or ovarian c ... Full text Link to item Cite

Molecular genetic features of ovarian cancer.

Journal Article Prog Clin Biol Res · 1996 Link to item Cite

A phase I/II study of high-dose cyclophosphamide, cisplatin, and thioTEPA followed by autologous bone marrow and granulocyte colony-stimulating factor-primed peripheral-blood progenitor cells in patients with advanced malignancies.

Journal Article Cancer Chemother Pharmacol · 1996 The purpose of the present study was to determine the maximally tolerated dose of thioTEPA given with fixed high-dose cyclophosphamide (CPA) and cisplatin (cDDP) followed by autologous bone marrow (ABM) with or without granulocyte colony-stimulating factor ... Full text Link to item Cite

Early ovarian cancer: a review of its genetic and biologic factors, detection, and treatment.

Journal Article Curr Probl Cancer · 1996 Early-stage ovarian carcinoma requires comprehensive surgical staging; reexploration for patients who had suboptimal initial surgery would indicate an apparent early ovarian carcinoma. After proper surgery, patients can be subdivided into a high- or low-ri ... Link to item Cite

Early ovarian cancer: A review of ITS genetic and biologic factors, detection, and treatment

Journal Article Current Problems in Cancer · January 1, 1996 Early-stage ovarian carcinoma requires comprehensive surgical staging; reexploration for patients who had suboptimal initial surgery would indicate an apparent early ovarian carcinoma. After proper surgery, patients can be subdivided into a high- or low-ri ... Full text Cite

Detection and partial purification of a 30 kDa ovarian carcinoma-associated protein

Journal Article Cancer Molecular Biology · January 1, 1996 In an effort to identify novel ovarian tumor markers, we have attempted to detect proteins expressed and secreted from human ovarian cancer cells but not expressed from normal human ovarian epithelial cells. Human ovarian cancer cells and normal ovarian ep ... Cite

Pathogenesis of ovarian cancer: Role of ovulation and molecular changes

Conference OVARY: REGULATION, DYSFUNCTION AND TREATMENT · January 1, 1996 Link to item Cite

Microsatellite instability in gynecological sarcomas and in hMSH2 mutant uterine sarcoma cell lines defective in mismatch repair activity.

Journal Article Cancer Res · December 1, 1995 We have examined a panel of gynecological sarcomas for microsatellite instability. The genomic DNA from 11 of 44 sarcomas contained somatic alterations in the lengths of one or more di-, tri-, tetra-, or pentanucleotide microsatellite sequence markers, and ... Link to item Cite

5-Day methotrexate for women with metastatic gestational trophoblastic disease

Journal Article ACOG Current Journal Review · December 1, 1995 Cite

Molecular basis of endometrial cancer.

Journal Article Cancer · November 15, 1995 BACKGROUND: Most human cancers are thought to arise from alterations in oncogenes and tumor suppressor genes. METHODS: Molecular techniques have been used to identify specific genetic alterations in endometrial cancers. RESULTS: Overexpression of the HER-2 ... Full text Link to item Cite

Gestational trophoblastic disease metastatic to the central nervous system.

Journal Article Gynecol Oncol · November 1995 OBJECTIVE: To evaluate characteristics of patients with central nervous system (CNS) lesions of gestational trophoblastic disease (GTD) and determine prognostic and therapeutic implications applicable to management. METHODS: We retrospectively reviewed the ... Full text Link to item Cite

Soluble interleukin-2 receptor alpha is elevated in sera of patients with benign ovarian neoplasms and epithelial ovarian cancer.

Journal Article Cancer · November 1, 1995 BACKGROUND: Previous studies have established that soluble interleukin-2 receptor alpha (sIL-2R alpha) levels are elevated in ascites and sera from individuals with advanced ovarian cancer (International Federation of Gynecology and Obstetrics [FIGO] Stage ... Full text Link to item Cite

Does aggressive therapy improve survival in suboptimal stage IIIc/IV ovarian cancer? A Canadian-American comparative study.

Journal Article Gynecol Oncol · November 1995 In an effort to determine if differences exist in the treatment and outcome of patients with suboptimally debulked stage IIIc and IV epithelial ovarian cancer between two tertiary-care cancer centers in Canada and the United States, we conducted a comparat ... Full text Link to item Cite

Postsurgical surveillance of patients with FIGO stage I/II endometrial adenocarcinoma.

Journal Article Gynecol Oncol · October 1995 OBJECTIVE: To examine the effect of postsurgical surveillance on survival of patients with FIGO stage I/II endometrial adenocarcinoma. METHODS: We examined the records of 354 patients who underwent primary surgical therapy for FIGO stage I/II endometrial a ... Full text Link to item Cite

Relationship between race and interval to treatment in endometrial cancer.

Journal Article Obstet Gynecol · October 1995 OBJECTIVE: To determine whether the poor prognosis of black women with endometrial adenocarcinoma is due to racial differences in the interval between the onset of abnormal uterine bleeding and hysterectomy. METHODS: Clinical records of all 219 patients (1 ... Full text Link to item Cite

Combinations of multiple serum markers are superior to individual assays for discriminating malignant from benign pelvic masses.

Journal Article Gynecol Oncol · October 1995 To determine whether measurement of the levels of multiple tumor markers in the preoperative serum of women presenting with a pelvic mass distinguished benign from malignant disease better than the assay of CA 125 alone, sera from 429 patients, 192 of whom ... Full text Link to item Cite

Mutational analysis of the estrogen-receptor gene in endometrial carcinoma.

Journal Article Obstet Gynecol · July 1995 OBJECTIVE: To determine whether mutation in the DNA of the estrogen-receptor gene occurs in endometrial cancer. METHODS: Polymerase chain reaction amplification and single-stranded conformation polymorphism analysis of the entire coding region (exons 1-8) ... Full text Link to item Cite

Chemotherapy-induced apoptosis in epithelial ovarian cancers.

Journal Article Obstet Gynecol · June 1995 OBJECTIVE: To determine whether chemotherapy drugs elicit programmed cell death (apoptosis) in ovarian cancer cells. METHODS: Monolayers of immortalized ovarian cancer cell lines and primary ovarian cancer cells obtained from ascites were grown in the pres ... Full text Link to item Cite

Distribution of integrin cell adhesion molecules in endometrial cancer.

Journal Article Am J Pathol · March 1995 Integrins are ubiquitous cell adhesion molecules that are involved in maintaining normal tissue morphology and have been implicated in the behavior of certain malignancies. We examined the expression of nine integrin subunits in 38 endometrial adenocarcino ... Link to item Cite

Etoposide-platin combination therapy for chemorefractory gestational trophoblastic disease.

Journal Article Gynecol Oncol · March 1995 The purpose of this study was to determine activity of etoposide-platin combination chemotherapy for chemorefractory gestational trophoblastic disease. A retrospective review of patients treated with etoposide-platin chemotherapy for chemorefractory tropho ... Full text Link to item Cite

Loss of heterozygosity on chromosome 17q11-21 in cancers of women who have both breast and ovarian cancer.

Journal Article Am J Obstet Gynecol · March 1995 OBJECTIVE: Our purpose was to determine the frequency of allele loss in the region of the BRCA1 gene in cancers of women who have both breast and ovarian cancer. STUDY DESIGN: Four polymorphic microsatellite markers on chromosome 17q11-21 were examined by ... Full text Link to item Cite

Regulation of apoptosis in normal and malignant ovarian epithelial cells by transforming growth factor beta.

Journal Article Cancer Res · February 15, 1995 Previously, we found that transforming growth factor beta (TGF-beta) inhibits proliferation of normal human ovarian epithelial cells. In addition, although only 1 of 5 immortalized ovarian cancer cell lines was inhibited, TGF-beta inhibited proliferation o ... Link to item Cite

Long and short gracilis myocutaneous flaps for vulvovaginal reconstruction after radical pelvic surgery: comparison of flap-specific complications.

Journal Article Gynecol Oncol · February 1995 The purpose of this study was to determine the factors associated with flap-specific complications in patients receiving gracilis myocutaneous flaps for pelvic reconstruction, specifically to determine whether the short gracilis flap increases the risk of ... Full text Link to item Cite

Molecular approaches to prevention and detection of epithelial ovarian cancer.

Journal Article J Cell Biochem Suppl · 1995 More than 90% of epithelial ovarian cancers arise from single cells. Malignant transformation can be associated with a number of molecular alterations including upregulation of tyrosine kinases and phosphatases, physiologic activation o ras, mutation of p5 ... Full text Link to item Cite

Biomarkers in the endometrium.

Journal Article J Cell Biochem Suppl · 1995 A number of oncogenes and tumor suppressor genes that may serves as surrogate biomarkers of transformation are altered during the process of endometrial carcinogenesis. Overexpression of HER-2/neu occurs in 10% of endometrial adenocarcinomas and correlates ... Full text Link to item Cite

Biomarkers in the ovary.

Journal Article J Cell Biochem Suppl · 1995 Alterations in specific oncogenes and tumor suppressor genes that serve as surrogate markers of malignant transformation have been identified in ovarian cancers. Overexpression of the HER-2/neu oncogene occurs in approximately 30% of breast and ovarian can ... Link to item Cite

Relationship between race and interval to treatment in endometrial cancer

Journal Article Obstetrics and Gynecology · January 1, 1995 Objective: To determine whether the poor prognosis of black women with endometrial adenocarcinoma is due to racial differences in the interval between the onset of abnormal uterine bleeding and hysterectomy. Methods: Clinical records of all 219 patients (1 ... Full text Cite

Transforming growth factor beta 1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells.

Journal Article Cell Growth Differ · December 1994 Transforming growth factor beta (TGF beta) is an important regulator of cellular proliferation. In normal ovarian epithelial cells, TGF beta acts to inhibit growth. However, in ovarian cancer cell lines, this effect is usually lost. Although the regulatory ... Link to item Cite

Evaluation of prognostic factors and staging in gestational trophoblastic tumor.

Journal Article Obstet Gynecol · December 1994 OBJECTIVE: To evaluate factors influencing survival and compare current classification systems in women treated for malignant gestational trophoblastic tumor. METHODS: A consecutive series of 454 women treated between 1968-1992 was reviewed retrospectively ... Link to item Cite

Serum progesterone for the exclusion of early pregnancy in women at risk for recurrent gestational trophoblastic neoplasia.

Journal Article Obstet Gynecol · November 1994 OBJECTIVE: To evaluate the utility of the serum progesterone level for discriminating pregnancy from gestational trophoblastic neoplasia. METHODS: Serum progesterone levels were measured in 61 women with histories of trophoblastic disease who developed a r ... Link to item Cite

BRCA1 mutations in primary breast and ovarian carcinomas.

Journal Article Science · October 7, 1994 Loss of heterozygosity data from familial tumors suggest that BRCA1, a gene that confers susceptibility to ovarian and early-onset breast cancer, encodes a tumor suppressor. The BRCA1 region is also subject to allelic loss in sporadic breast and ovarian ca ... Full text Link to item Cite

Allelotype of endometrial carcinoma.

Journal Article Cancer Res · August 15, 1994 An allelotype analysis of endometrial carcinoma was undertaken to identify chromosomal loci that are relevant to this tumor type. A total of 70 highly polymorphic microsatellite markers, distributed among all nonacrocentric chromosome arms, were examined f ... Link to item Cite

5-day methotrexate for women with metastatic gestational trophoblastic disease.

Journal Article Gynecol Oncol · July 1994 The objective of this study was to analyze the toxicity and the efficacy of single-agent 5-day methotrexate for women with metastatic gestational trophoblastic disease. The study is a retrospective analysis of 52 patients who received repetitive 5-day cycl ... Full text Link to item Cite

Transforming growth factor-beta inhibits proliferation of human ovarian cancer cells obtained from ascites.

Journal Article Cancer · July 1, 1994 BACKGROUND: Previously, the authors found that immortalized ovarian cancer cell lines generally were resistant to the growth inhibitory effect of transforming growth factor-beta and frequently had lost the ability to produce or activate this growth factor. ... Full text Link to item Cite

Multivariable analysis of DNA ploidy, p53, and HER-2/neu as prognostic factors in endometrial cancer.

Journal Article Cancer · May 1, 1994 BACKGROUND: Several molecular-genetic alterations in endometrial cancers, including aneuploidy and aberrant expression of p53 and HER-2/neu, have been associated with poor prognosis. To determine the importance of molecular-genetic factors relative to more ... Full text Link to item Cite

Mutations of the E-cadherin gene in human gynecologic cancers.

Journal Article Nat Genet · May 1994 Expression of the E-cadherin cell adhesion molecule is reduced in several types of human carcinomas, and the protein serves as an invasion suppressor in vitro. To determine if mutations of the E-cadherin gene (on chromosome 16q22) contribute to epithelial ... Full text Link to item Cite

Overexpression of the tyrosine phosphatase PTP1B is associated with human ovarian carcinomas.

Journal Article Am J Obstet Gynecol · April 1994 OBJECTIVE: Our purpose was to determine whether protein tyrosine phosphatase 1B is overexpressed in ovarian cancers, possibly altering the balance of intracellular tyrosine phosphorylation. STUDY DESIGN: The expression of protein tyrosine phosphatase 1B wa ... Full text Link to item Cite

OVX1 as a marker for early stage endometrial carcinoma.

Journal Article Cancer · April 1, 1994 BACKGROUND: Endometrial carcinoma is generally diagnosed only after the onset of postmenopausal bleeding. Although most patients with Stage I disease can be cured, the prognosis worsens significantly when the tumor is no longer confined to the uterine corp ... Full text Link to item Cite

Transfection of ovarian cancer cells with tumor necrosis factor-alpha (TNF-alpha) antisense mRNA abolishes the proliferative response to interleukin-1 (IL-1) but not TNF-alpha.

Journal Article Gynecol Oncol · April 1994 Recombinant interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) can induce endogenous TNF-alpha mRNA expression and stimulate proliferation of epithelial ovarian cancer cells. In a previous report, proliferation induced by either cytokine coul ... Full text Link to item Cite

Overexpression of the protein tyrosine phosphatase PTP1B in human breast cancer: association with p185c-erbB-2 protein expression.

Journal Article J Natl Cancer Inst · March 2, 1994 BACKGROUND: The p185c-erbB-2 growth factor receptor protein tyrosine kinase (PTK) is overexpressed in one third of human breast cancer patients and indicates a poor prognosis in these patients. Protein tyrosine phosphatases (PTPs) may balance PTK activity ... Full text Link to item Cite

The negative prognostic implications of thrombocytosis in women with stage IB cervical cancer.

Journal Article Obstet Gynecol · March 1994 OBJECTIVE: To determine the association between pretreatment platelet count and survival in women with stage IB cervical cancer. METHODS: Clinical records were reviewed for 219 women with stage IB cervical cancer treated by radical hysterectomy from 1971-1 ... Link to item Cite

Preoperative coagulation testing on a gynecologic oncology service.

Journal Article Obstet Gynecol · March 1994 OBJECTIVE: To determine the prevalence and clinical significance of abnormalities of preoperative coagulation tests in gynecologic oncology patients. METHODS: Three hundred fifty-one patients presenting for inpatient surgical procedures on the gynecologic ... Link to item Cite

Determination of proliferation index with MIB-1 in advanced ovarian cancer using quantitative image analysis.

Journal Article Am J Clin Pathol · February 1994 A new monoclonal antibody, MIB-1, reacts with the same epitope recognized by Ki-67. The authors investigated the feasibility of using image analysis to quantitate the MIB-1 staining (proliferation index [PI]) of epithelial ovarian cancers. The PI was deter ... Full text Link to item Cite

Overexpression of p53 is not a feature of benign and early-stage borderline epithelial ovarian tumors.

Journal Article Gynecol Oncol · February 1994 Since overexpression of mutant p53 protein is a common feature of invasive epithelial ovarian cancers, we investigated whether overexpression of the p53 tumor suppressor gene product occurs in benign and borderline epithelial ovarian tumors. Immunohistoche ... Full text Link to item Cite

Second-look laparotomy in ovarian cancer

Journal Article Gynecologic Oncology · January 1, 1994 The role of the second-look laparotomy has become standard management in the patients with ovarian cancer without any objective evidence that it has a major impact on survival. In patients with early-stage disease, data on second-look surgery would suggest ... Full text Cite

Differential expression of the 67-kD laminin receptor and 31-kD human laminin-binding protein in human ovarian carcinomas.

Journal Article Eur J Cancer · 1994 The expression of the 67-kD laminin receptor (67LR) and the 31-kD human laminin-binding protein (HLBP31), two proteins involved in cancer cell laminin interaction, was evaluated on 30 ovarian cancer specimens. Expression of the 67LR was increased (up to 2. ... Full text Link to item Cite

The p53 tumor suppressor gene frequently is altered in gynecologic cancers.

Journal Article Am J Obstet Gynecol · January 1994 Mutation of the p53 tumor suppressor gene, often accompanied by overexpression of mutant p53 protein, is the most frequent molecular genetic event described thus far in human cancers. In adenocarcinomas of the ovary and endometrium, p53 overexpression is s ... Full text Link to item Cite

Alternating weekly chemotherapy with etoposide-methotrexate-dactinomycin/cyclophosphamide-vincristine for high-risk gestational trophoblastic disease.

Journal Article Obstet Gynecol · January 1994 OBJECTIVE: To evaluate the response rate and toxicity of alternating weekly therapy with etoposide-methotrexate-dactinomycin/cyclophosphamide-vincristine for women with high-risk gestational trophoblastic disease. METHODS: Twenty-two women with gestational ... Link to item Cite

Pathogenesis of ovarian cancers.

Journal Article J Soc Gynecol Investig · 1994 OBJECTIVE: To review our current understanding of the molecular genetic events involved in the development of epithelial ovarian cancers. METHODS: Molecular biologic techniques have been used to examine the role of growth-stimulatory genes (oncogenes) and ... Full text Link to item Cite

Mutation and overexpression of the p53 tumor suppressor gene frequently occurs in uterine and ovarian sarcomas.

Journal Article Obstet Gynecol · January 1994 OBJECTIVE: To determine the frequency of mutation and overexpression of the p53 tumor suppressor gene in female genital tract sarcomas. METHODS: Immunostaining for p53 was performed in frozen sections of 46 ovarian and uterine sarcomas. Single-stranded con ... Link to item Cite

THE P53 TUMOR-SUPPRESSOR GENE FREQUENTLY IS ALTERED IN GYNECOLOGIC CANCERS

Journal Article AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY · January 1, 1994 Link to item Cite

Intraperitoneal cisplatin and regional hyperthermia for ovarian carcinoma.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 1993 PURPOSE: To review the theoretical basis and results of a Phase I study of concurrent intraperitoneal cisplatin and hyperthermia in the treatment of ovarian carcinoma. METHODS AND MATERIALS: Previously treated patients with epithelial ovarian carcinoma rec ... Full text Link to item Cite

Interval to treatment in endometrial cancer.

Journal Article Am J Obstet Gynecol · December 1993 Full text Link to item Cite

Prevention of superficial wound separation with subcutaneous retention sutures.

Journal Article Gynecol Oncol · December 1993 The objective of this prospective study was to determine the efficacy of subcutaneous retention sutures in the prevention of superficial wound separation in obese women undergoing gynecologic surgery. From 1985 to 1990, 80 women with subcutaneous tissue of ... Full text Link to item Cite

Elevation of multiple serum markers in patients with stage I ovarian cancer.

Journal Article J Natl Cancer Inst · November 3, 1993 BACKGROUND: The high overall mortality from ovarian cancer (> 60%) relates, in part, to delays in diagnosis. When ovarian cancer is detected in stage I (International Federation of Gynecology and Obstetrics staging), up to 90% of patients can be cured. Tra ... Full text Link to item Cite

Genetic instability of microsatellites in endometrial carcinoma.

Journal Article Cancer Res · November 1, 1993 Hereditary nonpolyposis colorectal cancer (HNPCC) is characterized by a familial predisposition to colorectal carcinoma and extracolonic cancers of the gastrointestinal, urological, and female reproductive tracts, notably the endometrium. A genetic locus f ... Link to item Cite

SCREENING STRATEGIES FOR OVARIAN-CANCER

Journal Article DIAGNOSTIC ONCOLOGY · November 1, 1993 Link to item Cite

Spectrum of mutation and frequency of allelic deletion of the p53 gene in ovarian cancer.

Journal Article J Natl Cancer Inst · September 15, 1993 BACKGROUND: The p53 gene encodes a nuclear phosphoprotein present in low levels in normal human cells. The wild-type form of this protein functions to restrain inappropriate cellular proliferation. Approximately one half of human epithelial ovarian cancers ... Full text Link to item Cite

Mutation of the p53 tumor-suppressor gene is not a feature of endometrial hyperplasias.

Journal Article Am J Obstet Gynecol · September 1993 OBJECTIVE: Mutation and overexpression of the p53 gene occur in approximately 20% of endometrial carcinomas. To determine whether alteration of the p53 gene is an early event in endometrial carcinogenesis, we examined the p53 gene in endometrial hyperplasi ... Full text Link to item Cite

The biology of ovarian cancer.

Journal Article Curr Opin Oncol · September 1993 Recent studies have begun to elucidate the molecular events involved in the development of ovarian cancer. First, it has been shown that epithelial ovarian cells both produce and have receptors for many peptide growth factors. It is possible that these gro ... Full text Link to item Cite

MICROSATELLITE INSTABILITY IN SPORADIC ENDOMETRIAL CARCINOMAS AND THOSE ASSOCIATED WITH HNPCC

Journal Article AMERICAN JOURNAL OF HUMAN GENETICS · September 1, 1993 Link to item Cite

Constitutive production of macrophage colony-stimulating factor and interleukin-6 by human ovarian surface epithelial cells.

Journal Article Exp Cell Res · August 1993 Normal and neoplastic epithelial cells produce growth factors that can affect cells from different lineages. Epithelial ovarian cancers produce M-CSF and IL-6. In the present study, production of these cytokines has been measured in the apparently normal e ... Full text Link to item Cite

OVX1 radioimmunoassay complements CA-125 for predicting the presence of residual ovarian carcinoma at second-look surgical surveillance procedures.

Journal Article J Clin Oncol · August 1993 PURPOSE: At second-look surgical surveillance procedures, normal CA-125 levels can be associated with persistent disease in 50% to 60% of patients. A novel radioimmunoassay (RIA) has been evaluated for the ability to identify patients with persistent disea ... Full text Link to item Cite

Serum levels of HER-2 neu (C-erbB-2) correlate with overexpression of p185neu in human ovarian cancer.

Journal Article Cancer · June 15, 1993 BACKGROUND: The HER-2 neu (c-erbB-2) oncogene product p185neu is expressed by most ovarian cancers and overexpressed in approximately 30%. METHODS: Sera from patients with ovarian cancer were evaluated for neu antigen using an enzyme-linked immunoassay and ... Full text Link to item Cite

Determination of proliferation index in advanced ovarian cancer using quantitative image analysis.

Journal Article Am J Clin Pathol · June 1993 It has been shown that the monoclonal antibody Ki-67 reacts with a nuclear antigen that is expressed only by proliferating cells. The feasibility of using image analysis to quantitate Ki-67 staining (proliferation index [PI]) of epithelial ovarian cancers ... Full text Link to item Cite

Mutation and overexpression of p53 in early-stage epithelial ovarian cancer.

Journal Article Obstet Gynecol · May 1993 OBJECTIVE: To investigate whether mutation and overexpression of p53 is a feature of early-stage ovarian cancers. METHODS: Because early-stage ovarian cancers are relatively uncommon, we adapted p53 immunostaining and DNA sequencing methods for use in para ... Link to item Cite

Mutation of the Ki-ras protooncogene in human endometrial hyperplasia and carcinoma.

Journal Article Cancer Res · April 15, 1993 Previous studies have demonstrated that some human endometrial carcinomas contain an activating point mutation in codon 12 of the Ki-ras protooncogene. To examine the hypothesis that this mutation may occur at an earlier stage of neoplastic progression in ... Link to item Cite

Tumor necrosis factor alpha as an autocrine and paracrine growth factor for ovarian cancer: monokine induction of tumor cell proliferation and tumor necrosis factor alpha expression.

Journal Article Cancer Res · April 15, 1993 Ovarian tumor cells produce macrophage colony stimulating factor, a potent chemoattractant for monocytes. Monocytes and macrophages produce tumor necrosis factor alpha (TNF-alpha) and interleukin 1 alpha or interleukin 1 beta (IL-1 beta) that can stimulate ... Link to item Cite

A randomized trial of low-dose heparin and intermittent pneumatic calf compression for the prevention of deep venous thrombosis after gynecologic oncology surgery.

Journal Article Am J Obstet Gynecol · April 1993 OBJECTIVE: Our aim was to determine the relative efficacy and complications of low-dose heparin and intermittent pneumatic calf compression for the prevention of postoperative venous thrombosis in patients undergoing surgery for gynecologic malignancy. STU ... Full text Link to item Cite

A deletion unit on chromosome 17q in epithelial ovarian tumors distal to the familial breast/ovarian cancer locus.

Journal Article Cancer Res · March 15, 1993 Linkage analysis in familial breast and ovarian cancer and studies of allelic deletion in sporadic ovarian tumors have suggested that chromosome 17q may be the location of a gene of importance in ovarian carcinogenesis. We have examined tumor and normal DN ... Link to item Cite

Cell growth regulation in epithelial ovarian cancer.

Journal Article Cancer · February 15, 1993 BACKGROUND: As in the case of other epithelial neoplasms, most ovarian cancers arise from single clones of cells that have undergone multiple genetic alterations. A comparison of normal and malignant ovarian epithelium has identified several differences in ... Full text Link to item Cite

Antibody-induced growth inhibition is mediated through immunochemically and functionally distinct epitopes on the extracellular domain of the c-erbB-2 (HER-2/neu) gene product p185.

Journal Article Int J Cancer · February 1, 1993 Over-expression of the c-erbB-2 (HER-2/neu) gene product p185 occurs in 30% of breast and ovarian cancers. The p185 protein might serve as a target for serotherapy in that antibodies against different epitopes on the extracellular domain of p185 can inhibi ... Full text Link to item Cite

Growth regulation and transformation of ovarian epithelium.

Journal Article Cancer · January 15, 1993 The discovery of peptide growth factors and cancer-causing genes (oncogenes and tumor-suppressor genes) has provided us with the exciting opportunity to begin to understand the molecular pathology of human ovarian cancer. Activation of several genes, inclu ... Full text Link to item Cite

The effect of antibodies and immunotoxins reactive with HER-2/neu on growth of ovarian and breast cancer cell lines.

Journal Article Am J Obstet Gynecol · January 1993 OBJECTIVE: Because HER-2/neu is overexpressed in one third of breast and ovarian cancers, we examined the effect of unconjugated monoclonal antibodies (ID-5, PB-3, TA-1) and an immunotoxin (TA-1-ricin) reactive with this protooncogene on the growth of brea ... Full text Link to item Cite

Mutation and overexpression of p53 in early-stage epithelial ovarian cancer

Journal Article Obstetrics and Gynecology · January 1, 1993 Objective: To investigate whether mutation and overexpression of p53 is a feature of early-stage ovarian cancers. Methods: Because early-stage ovarian cancers are relatively uncommon, we adapted p53 immunostaining and DNA sequencing methods for use in para ... Cite

Clonal origin of epithelial ovarian carcinoma: analysis by loss of heterozygosity, p53 mutation, and X-chromosome inactivation.

Journal Article J Natl Cancer Inst · December 2, 1992 BACKGROUND: It has been suggested that multiple sites of epithelial ovarian carcinoma on the peritoneal surface reflect polyclonal disease arising from multiple primary tumors in the peritoneal mesothelium, rather than monoclonal disease spread by metastas ... Full text Link to item Cite

The effect of interferon gamma on epidermal growth factor receptor expression in normal and malignant ovarian epithelial cells.

Journal Article Am J Obstet Gynecol · December 1992 OBJECTIVE: We examined the effect of interferon gamma on proliferation and epidermal growth factor receptor expression in ovarian cancer cell lines and normal ovarian epithelial cells. STUDY DESIGN: The tritiated thymidine incorporation assay was used to a ... Full text Link to item Cite

Comprehensive restaging laparotomy in women with apparent early ovarian carcinoma.

Journal Article Obstet Gynecol · December 1992 OBJECTIVE: To determine the yield and morbidity of comprehensive restaging laparotomy in women with presumed early ovarian carcinoma who have undergone incomplete initial staging procedures. METHODS: We conducted a retrospective review of 30 women with app ... Link to item Cite

Radical hysterectomy in obese women.

Journal Article Obstet Gynecol · December 1992 OBJECTIVE: To determine whether there is a significant difference in treatment outcome and acute and chronic complications in obese compared with non-obese women having radical hysterectomy for early-stage cervical cancer. METHODS: From 1970-1985, 320 wome ... Link to item Cite

Fibronectin is an immunosuppressive substance associated with epithelial ovarian cancer.

Journal Article Cancer · October 15, 1992 BACKGROUND: Although the ascites of patients with ovarian cancer has been reported to contain immunosuppressive factors, the identity and source of this activity has not been determined. Previously, the authors showed that conditioned media from two of fou ... Full text Link to item Cite

Improved palliation of cerebral metastases in epithelial ovarian cancer using a combined modality approach including radiation therapy, chemotherapy, and surgery.

Journal Article J Clin Oncol · October 1992 PURPOSE: Recent reports suggest an increasing incidence of CNS metastases in patients with ovarian cancer. We reviewed our experience in the management of brain metastases from ovarian carcinoma and merged our results with those of several other series rep ... Full text Link to item Cite

Biology and therapy with biologic agents in gynecologic cancer.

Journal Article Curr Opin Oncol · October 1992 Growth of epithelial ovarian cancer is influenced by several factors including transforming growth factor-alpha and transforming growth factor-beta, macrophage colony stimulating factor, tumor necrosis factor-alpha, interleukin-1 and interleukin-6, c-erb B ... Full text Link to item Cite

Oncogenes in ovarian cancer.

Journal Article Hematol Oncol Clin North Am · August 1992 The discovery of cancer-causing genes has provided us with the exciting opportunity to begin to understand the molecular pathology of ovarian cancer. Activation of several of these genes including HER-2/neu, myc, ras, and p53 has been described in some ova ... Link to item Cite

p53 overexpression in formalin-fixed, paraffin-embedded tissue detected by immunohistochemistry.

Journal Article J Histochem Cytochem · July 1992 Mutation and overexpression of the p53 gene have been noted in a wide range of human cancers and are thought to play a role in malignant transformation. Previously, immunohistochemical detection of p53 has been possible only in fresh-frozen tissues. We exa ... Full text Link to item Cite

Mutations of the Ki-ras oncogene in endometrial carcinoma.

Journal Article Am J Obstet Gynecol · July 1992 OBJECTIVE: The purpose of this study was to assess the extent of involvement of the ras oncogene in endometrial carcinoma. STUDY DESIGN: Genomic deoxyribonucleic acid from 30 samples of endometrial carcinoma was examined for point mutations in codons 12, 1 ... Full text Link to item Cite

Adjuvant therapy with intraperitoneal chromic phosphate (32P) in women with early ovarian carcinoma after comprehensive surgical staging.

Journal Article Obstet Gynecol · June 1992 From 1974-1990, 23 women with stage I and five with stage II epithelial ovarian carcinoma received intraperitoneal chromic phosphate (32P) as the only form of adjuvant therapy after complete debulking and comprehensive surgical staging laparotomy. Surgery ... Link to item Cite

Ha-ras polymorphisms in epithelial ovarian cancer.

Journal Article Gynecol Oncol · June 1992 Unusual restriction fragment length polymorphisms (RFLPs) of the Ha-ras locus have been found in DNA from leukocytes and tumor tissue of cancer patients. To determine whether rare alleles would be observed frequently in patients with ovarian cancer, Ha-ras ... Full text Link to item Cite

Malignant transformation of ovarian epithelium.

Journal Article J Natl Cancer Inst · April 15, 1992 Full text Link to item Cite

Overexpression and mutation of p53 in endometrial carcinoma.

Journal Article Cancer Res · March 15, 1992 Immunohistochemical staining for the p53 protein was performed in 107 snap frozen primary endometrial adenocarcinomas and 15 benign uterine tissues using monoclonal antibody PAb1801. No staining was seen in benign samples, whereas intense nuclear staining ... Link to item Cite

Regulation of growth of normal ovarian epithelial cells and ovarian cancer cell lines by transforming growth factor-beta.

Journal Article Am J Obstet Gynecol · February 1992 OBJECTIVE: The purpose of this study was to study the role of transforming growth factor-beta in regulation of proliferation of normal and malignant ovarian epithelial cells. STUDY DESIGN: We examined production of and responsiveness to transforming growth ... Full text Link to item Cite

Ploidy analysis of epithelial ovarian cancers using image cytometry.

Journal Article Gynecol Oncol · January 1992 We used a computerized image analysis system to determine the DNA content of 103 epithelial ovarian cancers using touch imprints of frozen tumor samples. Similar to prior studies of ploidy using flow cytometry, we found that most ovarian cancers (78%) were ... Full text Link to item Cite

NEW STRATEGIES FOR THE MANAGEMENT OF OVARIAN AND BREAST-CANCER BASED ON BIOLOGY AND PHARMACOLOGY

Conference CANCER CHEMOTHERAPY : CHALLENGES FOR THE FUTURE, VOL 7 · 1992 Link to item Cite

Increased serum levels of macrophage colony-stimulating factor in ovarian cancer.

Journal Article Am J Obstet Gynecol · November 1991 Macrophage colony-stimulating factor is a cytokine that stimulates proliferation and differentiation of phagocytic cells. Macrophage colony-stimulating factor is produced by ovarian epithelial cancer cell lines and might provide a useful serum marker for t ... Full text Link to item Cite

INCREASED SERUM LEVELS OF MACROPHAGE COLONY-STIMULATING FACTOR IN OVARIAN-CANCER

Journal Article AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY · November 1, 1991 Link to item Cite

Adjuvant intraperitoneal chromic phosphate therapy for women with apparent early ovarian carcinoma who have not undergone comprehensive surgical staging.

Journal Article Cancer · August 15, 1991 Forty-nine women with apparent Stage I and II ovarian carcinoma received intraperitoneal phosphate 32 as the only adjuvant therapy after primary surgery. In addition to bilateral salpingo-oophorectomy, 40 (82%) had analysis of peritoneal cytology, and 35 ( ... Full text Link to item Cite

Overexpression and mutation of p53 in epithelial ovarian cancer.

Journal Article Cancer Res · June 1, 1991 We examined p53 expression in 107 epithelial ovarian cancers with immunohistochemical techniques using monoclonal antibody PAb1801. High level expression of nuclear p53 protein was detected in the malignant epithelium in 54 (50%) of these cancers. Expressi ... Link to item Cite

The role of partial sigmoid colectomy for debulking epithelial ovarian carcinoma.

Journal Article Gynecol Oncol · June 1991 Forty women underwent partial sigmoid colectomy during cytoreductive surgery for advanced epithelial ovarian carcinoma. Twenty-one (53%) and nineteen (47%) received this as part of primary or secondary debulking procedures, respectively. Fifty-four percent ... Full text Link to item Cite

Stage I small cell carcinoma of the vulva treated with vulvectomy, lymphadenectomy, and adjuvant chemotherapy.

Journal Article Cancer · May 1, 1991 Neuroendocrine small cell carcinoma is a lethal, but rare, tumor that arises most frequently in the lung. Small cell cancer also rarely may occur in the female genital tract, usually in the cervix. This article concerns the fourth reported case of neuroend ... Full text Link to item Cite

Epidermal growth factor receptor expression in normal ovarian epithelium and ovarian cancer. II. Relationship between receptor expression and response to epidermal growth factor.

Journal Article Am J Obstet Gynecol · March 1991 Previously we have shown that epidermal growth factor acts as a mitogen for some, but not all, ovarian cancer cells in culture. In this study we examined the effect of epidermal growth factor on proliferation of normal human ovarian epithelial cells in mon ... Full text Link to item Cite

Epidermal growth factor receptor expression in normal ovarian epithelium and ovarian cancer. I. Correlation of receptor expression with prognostic factors in patients with ovarian cancer.

Journal Article Am J Obstet Gynecol · February 1991 Previous studies in breast and bladder cancer have suggested that epidermal growth factor receptor is expressed by only a proportion of cancers and is associated with poor clinical outcome. We used a monoclonal antibody specifically reactive with the extra ... Full text Link to item Cite

Overexpression of HER-2/neu in endometrial cancer is associated with advanced stage disease.

Journal Article Am J Obstet Gynecol · January 1991 Prior studies have shown that overexpression of HER-2/neu occurs in one third of breast and ovarian cancers and that overexpression is associated with poor prognosis. We used a monoclonal antibody to assess immunohistochemically the level of HER-2/neu expr ... Full text Link to item Cite

Increased serum levels of macrophage colony-stimulating factor in ovarian cancer

Journal Article American Journal of Obstetrics and Gynecology · January 1, 1991 Macrophage colony-stimulating factor is a cytokine that stimulates proliferation and differentiation of phagocytic cells. Macrophage colony-stimulating factor is produced by ovarian epithelial cancer cell lines and might provide a useful serum marker for t ... Full text Cite

Preoperative evaluation of serum CA 125, TAG 72, and CA 15-3 in patients with endometrial carcinoma.

Journal Article Am J Obstet Gynecol · October 1990 We evaluated 109 women with endometrial carcinoma to determine the accuracy of preoperative tumor-associated antigen levels (CA 125, CA 72, CA 15-3) for prediction of extrauterine disease and whether TAG 72, CA 15-3, or both would improve the predictive va ... Full text Link to item Cite

The prognostic significance of CA 125 half-life in patients with ovarian cancer who have received primary chemotherapy after surgical cytoreduction.

Journal Article Am J Obstet Gynecol · October 1990 Fifty-four patients with advanced epithelial ovarian cancer were monitored with serial serum CA 125 levels after surgical cytoreduction and during multi-agent chemotherapy with cisplatin-containing regimens. CA 125 half-life of less than 20 days was associ ... Full text Link to item Cite

Computed tomography-guided fine-needle aspiration of retroperitoneal lymph nodes in gynecologic oncology.

Journal Article Obstet Gynecol · October 1990 Computed tomography-guided fine-needle aspiration was performed on 30 retroperitoneal lymph nodes in 29 patients with gynecologic cancer. There were no serious complications. Review of the cytologic material demonstrated malignant cells in 83% of the aspir ... Link to item Cite

The role of tumor markers in gynecologic oncology.

Journal Article Obstet Gynecol Surv · September 1990 Human chorionic gonadotropin is a highly sensitive and specific tumor marker for gestational trophoblastic neoplasia that accurately reflects tumor volume and the clinical course of disease. In women with endodermal sinus tumors and embryonal carcinomas, a ... Full text Link to item Cite

Expression of epidermal growth factor receptor and HER-2/neu in normal and neoplastic cervix, vulva, and vagina.

Journal Article Obstet Gynecol · September 1990 Monoclonal antibodies were used to localize immunohistochemically epidermal growth factor receptor and HER-2/neu in normal and neoplastic frozen tissue samples from the lower genital tract of women. In squamous epithelia of the cervix, vulva, and vagina, e ... Link to item Cite

Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer.

Journal Article Cancer Res · July 1, 1990 Previous studies have suggested that overexpression of HER-2/neu oncogene occurs in 15-40% of breast cancers and that overexpression is associated with poor prognosis. In the present report, we have used an immunohistochemical technique involving a monoclo ... Link to item Cite

A comparison of symptomatology, physical examination, and vaginal cytology in the detection of recurrent cervical carcinoma after radical hysterectomy.

Journal Article Obstet Gynecol · July 1990 To evaluate our surveillance program for recurrent cervical carcinoma, we reviewed patients who underwent radical hysterectomy for International Federation of Gynecology and Obstetrics (FIGO) stages IB and IIA cervical cancer. The study group consisted of ... Link to item Cite

Adjuvant radiotherapy following radical hysterectomy for patients with stage IB and IIA cervical cancer.

Journal Article Gynecol Oncol · June 1990 From 1971 through 1984, 320 women underwent radical hysterectomy as primary therapy of stage IB and IIA cervical cancer. Two hundred forty-eight patients (78%) were treated with surgery alone and 72 patients (22%) received adjuvant postoperative external-b ... Full text Link to item Cite

Heterogeneity of antigen expression in advanced epithelial ovarian cancer.

Journal Article Am J Obstet Gynecol · April 1990 Immunohistochemical techniques were used to evaluate the expression of six antigens (CA 125, TAG 72, CA 19-9, OVTL3, DF3, and transferrin receptor) in frozen sections from the primary tumor and metastases of 20 patients with epithelial ovarian cancer. Hete ... Full text Link to item Cite

The role of peptide growth factors in epithelial ovarian cancer.

Journal Article Obstet Gynecol · February 1990 We studied the effect of epidermal growth factor, platelet-derived growth factor, fibroblast growth factor, and transforming growth factor-beta on proliferation of four epithelial ovarian cancer cell lines (OVCA 420, OVCA 429, OVCA 432, and OVCA 433). Epid ... Link to item Cite

Treatment of endometrial stromal tumors.

Journal Article Gynecol Oncol · January 1990 We reviewed 31 cases of endometrial stromal tumors treated on the Gynecology Service at Memorial Sloan-Kettering Cancer Center from 1970 to 1984. Twenty-two patients had endolymphatic stromal myosis and 9 patients had endometrial stromal sarcoma. Twenty-si ... Full text Link to item Cite

Gynecologic tumor markers.

Journal Article Semin Surg Oncol · 1990 The advent of monoclonal technology has increased the potential utility of antibody-dependent tumor marker assays in gynecologic oncology. The availability of unlimited quantities of several pure monoclonal antibodies directed against novel epitopes on tum ... Full text Link to item Cite

Expression of epidermal growth factor receptor and HER-2/neu in normal and neoplastic cervix, vulva, and vagina

Journal Article Obstetrics and Gynecology · January 1, 1990 Monoclonal antibodies were used to localize immunohisto-chemically epidermal growth factor receptor and HER-2/neu in normal and neoplastic frozen tissue samples from the lower genital tract of women. In squamous epithelia of the cervix, vulva, and vagina, ... Cite

Epidermal growth factor receptor expression in normal and malignant endometrium.

Journal Article Am J Obstet Gynecol · November 1989 Epidermal growth factor receptor expression in fresh-frozen uterine tissues was studied with the use of monoclonal antibody 528, which recognizes an epitope on the external domain of the epidermal growth factor receptor. Immunohistochemically detectable ep ... Full text Link to item Cite

Short gracilis myocutaneous flaps for vulvovaginal reconstruction after radical pelvic surgery.

Journal Article Obstet Gynecol · November 1989 The short gracilis myocutaneous flap derives its blood supply from terminal branches of the obturator artery, and the vascular pedicle derived from the medial femoral circumflex artery is sacrificed. Twenty-one short gracilis myocutaneous flaps were used f ... Link to item Cite

Immunohistochemical expression of TAG-72 in normal and malignant endometrium: correlation of antigen expression with estrogen receptor and progesterone receptor levels.

Journal Article Am J Obstet Gynecol · November 1989 TAG-72 is a tumor-associated antigen that is expressed by secretory endometrium and most endometrial adenocarcinomas. We used immunohistochemical techniques to quantitate expression of TAG-72, estrogen receptor, and progesterone receptor in 21 normal endom ... Full text Link to item Cite

Pelvic exenteration: factors associated with major surgical morbidity.

Journal Article Gynecol Oncol · October 1989 Sixty-nine women underwent pelvic exenteration at Duke University Medical Center from 1970 through 1987. The operative mortality rate was 7.2% with a trend toward a reduction during the course of the study. One or more serious gastrointestinal or genitouri ... Full text Link to item Cite

Transforming growth factor-beta inhibits prostaglandin production in amnion and A431 cells.

Journal Article Prostaglandins · October 1989 We studied the effect of transforming growth factor-beta (TGF-beta) on prostaglandin E2 (PGE2) production and mitogenesis in human amnion cells and compared the response in amnion cells with that in A431 cells. Both amnion cells and A431 cells respond to e ... Full text Link to item Cite

Reactivity of epidermal growth factor receptor monoclonal antibodies with human uterine tissues.

Journal Article Arch Pathol Lab Med · October 1989 Two monoclonal antibodies (29.1 and 528), which were raised against the epidermal growth factor receptor, were used to evaluate expression of epidermal growth factor receptor in frozen uterine tissue with immunohistochemical techniques. Monoclonal antibody ... Link to item Cite

Pneumoperitoneum due to peritoneovaginal fistula following hysterectomy.

Journal Article Int J Gynaecol Obstet · July 1989 A patient with pneumoperitoneum that developed due to peritoneovaginal fistula following hysterectomy is presented. In addition, we have reviewed the literature and formulated guidelines for the management of this problem. Most patients present following s ... Full text Link to item Cite

Immunohistochemical expression of CA 125 in endometrial adenocarcinoma: correlation of antigen expression with metastatic potential.

Journal Article Cancer Res · April 15, 1989 Immunohistochemical localization of CA 125 using murine monoclonal antibody OC 125 was performed on fresh frozen tissue from 44 endometrial adenocarcinomas and 26 benign endometria. Immunohistochemical evaluation incorporated both intensity and distributio ... Link to item Cite

Effect of epidermal growth factor on ornithine decarboxylase activity in A431 cells.

Journal Article Anticancer Res · 1989 Epidermal growth factor (EGF) stimulates mitogenesis in a number of cell lines; but in A431 cells, EGF causes inhibition of replication. To investigate the possibility that an alteration in the polyamine biosynthetic pathway could be associated with this u ... Link to item Cite

Treatment of uterine leiomyosarcoma.

Journal Article Obstet Gynecol · June 1988 We reviewed 46 cases treated at the Gynecology Service of Memorial Sloan-Kettering Cancer Center from 1970-1984 to evaluate the impact of modern multimodal therapy on survival of patients with uterine leiomyosarcoma. Eighteen patients had their primary tre ... Link to item Cite

Epidermal growth factor, vanadate, and 12-O-tetradecanoylphorbol-13-acetate inhibit growth and stimulate prostaglandin E2 production in A431 cells.

Journal Article Mol Cell Endocrinol · May 1988 The cell line designated as A431 is characterized by an extraordinary capacity for binding of epidermal growth factor (EGF); but paradoxically, these cells also are characterized by failure of replication in response to treatment with EGF and other mitogen ... Full text Link to item Cite

Treatment of uterine leiomyosarcoma

Journal Article Obstetrics and Gynecology · January 1, 1988 We reviewed 46 cases treated at the Gynecology Service of Memorial Sloan-Kettering Cancer Center from 1970-1984 to evaluate the impact of modem multimodal therapy on survival of patients with uterine leiomyosarcoma. Eighteen patients had their primary trea ... Cite

Cervical adenoid cystic carcinoma associated with ascites.

Journal Article Gynecol Oncol · October 1985 Two new cases of cervical adenoid cystic carcinoma are reported. The addition of these two cases brings the total number of reported cases in the literature to 88 making this the most common gynecologic site of occurrence for this unusual tumor. Ascites de ... Full text Link to item Cite

Cervicovaginal fistula formation: a new complication of Shirodkar cerclage.

Journal Article Am J Perinatol · April 1984 In this article, cervicovaginal fistula formation is reported for the first time as a complication of failure to remove a cervical cerclage during labor. Along with the available literature, the case presented here suggests the value of timely removal of a ... Full text Link to item Cite