Andrew Berchuck

Journal Article Gynecol Oncol · November 2024 OBJECTIVE: Ovarian cancer has poor 5-year survival, particularly among non-Hispanic (NH) Black patients. Efforts to identify patients at high-risk of functional limitations and frailty may improve outcomes. In this study, we examined how healthcare access ... Full text Link to item Cite

Oncolytic adenovirus MEM-288 encoding membrane-stable CD40L and IFNβ induces an anti-tumor immune response in high grade serous ovarian cancer.

Journal Article Neoplasia · November 2024 Single agent immune checkpoint inhibitors have been ineffective for patients with advanced stage and recurrent high grade serous ovarian cancer (HGSOC). Using pre-clinical models of HGSOC, we evaluated the anti-tumor and immune stimulatory effects of an on ... Full text Link to item Cite

Metformin use and survival in people with ovarian cancer: A population-based cohort study from British Columbia, Canada.

Journal Article Neoplasia · October 2024 OBJECTIVES: There is an active debate regarding whether metformin use improves survival in people with ovarian cancer. We examined this issue using methods designed to avoid immortal time bias-as bias that occurs when participants in a study cannot experie ... Full text Link to item Cite

Pre-diagnosis tea and coffee consumption and survival after a diagnosis of ovarian cancer: results from the Ovarian Cancer Association Consortium.

Journal Article Br J Cancer · October 2024 BACKGROUND: Tea and coffee are the most frequently consumed beverages in the world. Green tea in particular contains compounds with potential anti-cancer effects, but its association with survival after ovarian cancer is uncertain. METHODS: We investigated ... Full text Link to item Cite

NCCN Guidelines® Insights: Ovarian Cancer/Fallopian Tube Cancer/Primary Peritoneal Cancer, Version 3.2024.

Journal Article J Natl Compr Canc Netw · October 2024 The NCCN Guidelines for Ovarian Cancer/Fallopian Tube Cancer/Primary Peritoneal Cancer provide multidisciplinary diagnostic workup, staging, and treatment recommendations for this disease. These NCCN Guidelines Insights detail how the evolution of the use ... Full text Link to item Cite

Racial and ethnic differences in epithelial ovarian cancer risk: an analysis from the Ovarian Cancer Association Consortium.

Journal Article Am J Epidemiol · September 3, 2024 Limited estimates exist on risk factors for epithelial ovarian cancer (EOC) in Asian, Hispanic, and Native Hawaiian/Pacific Islander women. Participants in this study included 1734 Asian (n = 785 case and 949 control participants), 266 Native Hawaiian/Paci ... Full text Link to item Cite

Concurrent RB1 Loss and BRCA Deficiency Predicts Enhanced Immunologic Response and Long-term Survival in Tubo-ovarian High-grade Serous Carcinoma.

Journal Article Clin Cancer Res · August 15, 2024 PURPOSE: The purpose of this study was to evaluate RB1 expression and survival across ovarian carcinoma histotypes and how co-occurrence of BRCA1 or BRCA2 (BRCA) alterations and RB1 loss influences survival in tubo-ovarian high-grade serous carcinoma (HGSC ... Full text Link to item Cite

Molecular Subtypes of High-Grade Serous Ovarian Cancer across Racial Groups and Gene Expression Platforms.

Journal Article Cancer Epidemiol Biomarkers Prev · August 1, 2024 BACKGROUND: High-grade serous carcinoma (HGSC) gene expression subtypes are associated with differential survival. We characterized HGSC gene expression in Black individuals and considered whether gene expression differences by self-identified race may con ... Full text Link to item Cite

Health Care Access Dimensions and Racial Disparities in End-of-Life Care Quality among Patients with Ovarian Cancer.

Journal Article Cancer Res Commun · March 18, 2024 UNLABELLED: This study investigated the association between health care access (HCA) dimensions and racial disparities in end-of-life (EOL) care quality among non-Hispanic Black (NHB), non-Hispanic White (NHW), and Hispanic patients with ovarian cancer. Th ... Full text Link to item Cite

Genome-wide association analyses of ovarian cancer patients undergoing primary debulking surgery identify candidate genes for residual disease.

Journal Article NPJ Genom Med · March 5, 2024 Survival from ovarian cancer depends on the resection status after primary surgery. We performed genome-wide association analyses for resection status of 7705 ovarian cancer patients, including 4954 with high-grade serous carcinoma (HGSOC), to identify var ... Full text Link to item Cite

Advancing Cancer Care Infrastructure in Cambodia: Summary of the First 100 Patients with Cervical Cancer Treated at the National Cancer Centre

Journal Article Asia Pacific Journal of Cancer Biology · January 1, 2024 Background: Cervical cancer is Cambodia’s leading cause of female malignancy in both incidence and mortality. Cambodia’s first dedicated multidisciplinary cancer center, the National Cancer Centre (NCC), opened in January 2018 in Phnom Penh, and serves as ... Full text Cite

Periostin facilitates ovarian cancer recurrence by enhancing cancer stemness.

Journal Article Sci Rep · December 4, 2023 The lethality of epithelial ovarian cancer (OC) is largely due to a high rate of recurrence and development of chemoresistance, which requires synergy between cancer cells and the tumor microenvironment (TME) and is thought to involve cancer stem cells. Ou ... Full text Open Access Link to item Cite

Lifetime ovulatory years and risk of epithelial ovarian cancer: a multinational pooled analysis.

Journal Article J Natl Cancer Inst · May 8, 2023 BACKGROUND: The role of ovulation in epithelial ovarian cancer (EOC) is supported by the consistent protective effects of parity and oral contraceptive use. Whether these factors protect through anovulation alone remains unclear. We explored the associatio ... Full text Link to item Cite

Health-care access dimensions and ovarian cancer survival: SEER-Medicare analysis of the ORCHiD study.

Journal Article JNCI Cancer Spectr · March 1, 2023 BACKGROUND: Racial and ethnic disparities in ovarian cancer (OC) survival are well-documented. However, few studies have investigated how health-care access (HCA) contributes to these disparities. METHODS: To evaluate the influence of HCA on OC mortality, ... Full text Link to item Cite

Factor Analysis of Health Care Access With Ovarian Cancer Surgery and Gynecologic Oncologist Consultation.

Journal Article JAMA Netw Open · February 1, 2023 IMPORTANCE: Poor health care access (HCA) is associated with racial and ethnic disparities in ovarian cancer (OC) survival. OBJECTIVE: To generate composite scores representing health care affordability, availability, and accessibility via factor analysis ... Full text Link to item Cite

Association of Frequent Aspirin Use With Ovarian Cancer Risk According to Genetic Susceptibility.

Journal Article JAMA Netw Open · February 1, 2023 IMPORTANCE: Frequent aspirin use is associated with reduced ovarian cancer risk, but it is unknown whether genetic factors modify this association. Understanding effect modifiers is important given that any use of aspirin for ovarian cancer chemoprevention ... Full text Link to item Cite

Concordance Between Genomic Alterations Detected by Tumor and Germline Sequencing: Results from a Tertiary Care Academic Center Molecular Tumor Board.

Journal Article Oncologist · January 18, 2023 OBJECTIVE: The majority of tumor sequencing currently performed on cancer patients does not include a matched normal control, and in cases where germline testing is performed, it is usually run independently of tumor testing. The rates of concordance betwe ... Full text Open Access Link to item Cite

Healthcare Access Domains Mediate Racial Disparities in Ovarian Cancer Treatment Quality in a US Patient Cohort: A Structural Equation Modelling Analysis.

Journal Article Cancer Epidemiol Biomarkers Prev · January 9, 2023 BACKGROUND: Ovarian cancer survival disparities have persisted for decades, driven by lack of access to quality treatment. We conducted structural equation modeling (SEM) to define latent variables representing three healthcare access (HCA) domains: afford ... Full text Link to item Cite

Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study.

Journal Article Br J Cancer · January 2023 BACKGROUND: Recently, we showed a >60% difference in 5-year survival for patients with tubo-ovarian high-grade serous carcinoma (HGSC) when stratified by a 101-gene mRNA expression prognostic signature. Given the varied patient outcomes, this study aimed t ... Full text Link to item Cite

Modification of the Association Between Frequent Aspirin Use and Ovarian Cancer Risk: A Meta-Analysis Using Individual-Level Data From Two Ovarian Cancer Consortia.

Journal Article J Clin Oncol · December 20, 2022 PURPOSE: Frequent aspirin use has been associated with reduced ovarian cancer risk, but no study has comprehensively assessed for effect modification. We leveraged harmonized, individual-level data from 17 studies to examine the association between frequen ... Full text Link to item Cite

Development and Psychometric Evaluation of Healthcare Access Measures among Women with Ovarian Cancer.

Journal Article Cancers (Basel) · December 19, 2022 Several proposed theoretical frameworks have defined the complex nature of healthcare access (HCA) [...]. ... Full text Link to item Cite

Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes.

Journal Article Clin Cancer Res · December 15, 2022 PURPOSE: Advanced-stage mucinous ovarian carcinoma (MOC) has poor chemotherapy response and prognosis and lacks biomarkers to aid stage I adjuvant treatment. Differentiating primary MOC from gastrointestinal (GI) metastases to the ovary is also challenging ... Full text Link to item Cite

Race, Affordability and Utilization of Supportive Care in Ovarian Cancer Patients.

Journal Article J Pain Symptom Manage · December 2022 OBJECTIVE: Lack of access to supportive care (SC) among cancer patients have been well documented. However, the role of affordability in this disparity among ovarian cancer (OC) patients remain poorly understood. METHODS: Patients with OC between 2008 and ... Full text Link to item Cite

Copy Number Variants Are Ovarian Cancer Risk Alleles at Known and Novel Risk Loci.

Journal Article J Natl Cancer Inst · November 14, 2022 BACKGROUND: Known risk alleles for epithelial ovarian cancer (EOC) account for approximately 40% of the heritability for EOC. Copy number variants (CNVs) have not been investigated as EOC risk alleles in a large population cohort. METHODS: Single nucleotid ... Full text Link to item Cite

Effects of risk factors for ovarian cancer in women with and without endometriosis.

Journal Article Fertil Steril · November 2022 OBJECTIVE: To evaluate the associations between 10 well-established ovarian cancer risk factors and risk of ovarian cancer among women with vs. without endometriosis. DESIGN: Pooled analysis of 9 case-control studies in the Ovarian Cancer Association Conso ... Full text Link to item Cite

Healthcare Access Dimensions and Guideline-Concordant Ovarian Cancer Treatment: SEER-Medicare Analysis of the ORCHiD Study.

Journal Article J Natl Compr Canc Netw · November 2022 BACKGROUND: Racial disparities exist in receipt of guideline-concordant treatment of ovarian cancer (OC). However, few studies have evaluated how various dimensions of healthcare access (HCA) contribute to these disparities. METHODS: We analyzed data from ... Full text Link to item Cite

Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer.

Journal Article Cell Rep · July 26, 2022 Growth factors in tumor environments are regulators of cell survival and metastasis. Here, we reveal the dichotomy between TGF-β superfamily growth factors BMP and TGF-β/activin and their downstream SMAD effectors. Gene expression profiling uncovers SOX2 a ... Full text Link to item Cite

G6PD inhibition sensitizes ovarian cancer cells to oxidative stress in the metastatic omental microenvironment.

Journal Article Cell Rep · June 28, 2022 Ovarian cancer (OC) is the most lethal gynecological malignancy, with aggressive metastatic disease responsible for the majority of OC-related deaths. In particular, OC tumors preferentially metastasize to and proliferate rapidly in the omentum. Here, we s ... Full text Link to item Cite

Hypoxia-induced inhibin promotes tumor growth and vascular permeability in ovarian cancers.

Journal Article Commun Biol · June 2, 2022 Hypoxia, a driver of tumor growth and metastasis, regulates angiogenic pathways that are targets for vessel normalization and ovarian cancer management. However, toxicities and resistance to anti-angiogenics can limit their use making identification of new ... Full text Link to item Cite

Racial Differences in the Tumor Immune Landscape and Survival of Women with High-Grade Serous Ovarian Carcinoma.

Journal Article Cancer Epidemiol Biomarkers Prev · May 4, 2022 BACKGROUND: Tumor-infiltrating lymphocytes (TIL) confer a survival benefit among patients with ovarian cancer; however, little work has been conducted in racially diverse cohorts. METHODS: The current study investigated racial differences in the tumor immu ... Full text Link to item Cite

CA-125 Levels Are Predictive of Survival in Low-Grade Serous Ovarian Cancer-A Multicenter Analysis.

Journal Article Cancers (Basel) · April 13, 2022 OBJECTIVE: Studies on low-grade serous ovarian cancer (LGSC) are limited by a low number of cases. The aim of this study was to define the prognostic significance of age, stage, and CA-125 levels on survival in a multi-institutional cohort of women with pa ... Full text Link to item Cite

Reproductive Factors Do Not Influence Survival with Ovarian Cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · April 1, 2022 BACKGROUND: Previous studies on the association between reproductive factors and ovarian cancer survival are equivocal, possibly due to small sample sizes. METHODS: Using data on 11,175 people diagnosed with primary invasive epithelial ovarian, fallopian t ... Full text Link to item Cite

High Prediagnosis Inflammation-Related Risk Score Associated with Decreased Ovarian Cancer Survival.

Journal Article Cancer Epidemiol Biomarkers Prev · February 2022 BACKGROUND: There is suggestive evidence that inflammation is related to ovarian cancer survival. However, more research is needed to identify inflammation-related factors that are associated with ovarian cancer survival and to determine their combined eff ... Full text Link to item Cite

Pleiotropic MLLT10 variation confers risk of meningioma and estrogen-mediated cancers

Conference Neuro-Oncology Advances · January 1, 2022 Background: Risk of tumors of the breast, ovary, and meninges has been associated with hormonal factors and with one another. Genome-wide association studies (GWAS) identified a meningioma risk locus on 10p12 near previous GWAS hits for breast and ovarian ... Full text Cite

Endometriosis and menopausal hormone therapy impact the hysterectomy-ovarian cancer association.

Journal Article Gynecol Oncol · January 2022 OBJECTIVE: To evaluate the association between hysterectomy and ovarian cancer, and to understand how hormone therapy (HT) use and endometriosis affect this association. METHODS: We conducted a pooled analysis of self-reported data from 11 case-control stu ... Full text Link to item Cite

Endometrial cancer

Chapter · January 1, 2022 The prior dichotomous classification of endometrial cancer into high and low risk subtypes based primarily on histology has been shown to be inadequate in predicting outcome and treatment response. More nuanced molecular categorization of these cancers pro ... Full text Cite

Endometrial Adenocarcinomas With No Specific Molecular Profile: Morphologic Features and Molecular Alterations of "Copy-number Low" Tumors.

Journal Article Int J Gynecol Pathol · November 1, 2021 The study evaluated morphologic patterns, mutational profiles, and β-catenin immunohistochemistry (IHC) in copy-number low (CNL) endometrial adenocarcinomas (EAs). CNL EAs (n=19) with next-generation or whole genome sequencing results and available tissue ... Full text Link to item Cite

Ovarian Cancer Epidemiology, Healthcare Access and Disparities (ORCHiD): methodology for a population-based study of black, Hispanic and white patients with ovarian cancer.

Journal Article BMJ Open · October 4, 2021 INTRODUCTION: Less than 40% of patients with ovarian cancer (OC) in the USA receive stage-appropriate guideline-adherent surgery and chemotherapy. Black patients with cancer report greater depression, pain and fatigue than white patients. Lack of access to ... Full text Link to item Cite

Identification of a Locus Near ULK1 Associated With Progression-Free Survival in Ovarian Cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · September 2021 BACKGROUND: Many loci have been found to be associated with risk of epithelial ovarian cancer (EOC). However, although there is considerable variation in progression-free survival (PFS), no loci have been found to be associated with outcome at genome-wide ... Full text Link to item Cite

Cardiovascular medications and survival in people with ovarian cancer: A population-based cohort study from British Columbia, Canada.

Journal Article Gynecol Oncol · August 2021 OBJECTIVES: Research examining survival among people with ovarian cancer following use of statins or β-blockers has been conflicting. Many studies to date have suffered from immortal time bias and/or had limited power. To address these limitations, we used ... Full text Link to item Cite

Pleiotropy-guided transcriptome imputation from normal and tumor tissues identifies candidate susceptibility genes for breast and ovarian cancer.

Journal Article HGG Adv · July 8, 2021 Familial, sequencing, and genome-wide association studies (GWASs) and genetic correlation analyses have progressively unraveled the shared or pleiotropic germline genetics of breast and ovarian cancer. In this study, we aimed to leverage this shared germli ... Full text Link to item Cite

Molecular Classification to Prognosticate Response in Medically Managed Endometrial Cancers and Endometrial Intraepithelial Neoplasia.

Journal Article Cancers · June 2021 BackgroundThe aim of this study was to evaluate whether molecular classification prognosticates treatment response in women with endometrial cancers and endometrial intraepithelial neoplasia (EIN) treated with levonorgestrel intrauterine system (L ... Full text Cite

Population-based targeted sequencing of 54 candidate genes identifies PALB2 as a susceptibility gene for high-grade serous ovarian cancer.

Journal Article J Med Genet · May 2021 PURPOSE: The known epithelial ovarian cancer (EOC) susceptibility genes account for less than 50% of the heritable risk of ovarian cancer suggesting that other susceptibility genes exist. The aim of this study was to evaluate the contribution to ovarian ca ... Full text Link to item Cite

Depot-Medroxyprogesterone Acetate Use Is Associated with Decreased Risk of Ovarian Cancer: The Mounting Evidence of a Protective Role of Progestins.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2021 BACKGROUND: Combined oral contraceptive use is associated with a decreased risk of invasive epithelial ovarian cancer (ovarian cancer). There is suggestive evidence of an inverse association between progestin-only contraceptive use and ovarian cancer risk, ... Full text Link to item Cite

Evaluating the role of alcohol consumption in breast and ovarian cancer susceptibility using population-based cohort studies and two-sample Mendelian randomization analyses.

Journal Article Int J Cancer · March 15, 2021 Alcohol consumption is correlated positively with risk for breast cancer in observational studies, but observational studies are subject to reverse causation and confounding. The association with epithelial ovarian cancer (EOC) is unclear. We performed bot ... Full text Link to item Cite

Expanding Our Understanding of Ovarian Cancer Risk: The Role of Incomplete Pregnancies.

Journal Article J Natl Cancer Inst · March 1, 2021 BACKGROUND: Parity is associated with decreased risk of invasive ovarian cancer; however, the relationship between incomplete pregnancies and invasive ovarian cancer risk is unclear. This relationship was examined using 15 case-control studies from the Ova ... Full text Link to item Cite

Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · February 2, 2021 Epithelial ovarian cancer is the leading cause of death from gynecologic cancer in the United States and is the country's fifth most common cause of cancer mortality in women. A major challenge in treating ovarian cancer is that most patients have advanced ... Full text Link to item Cite

A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization.

Journal Article Nat Commun · January 11, 2021 Previous Mendelian randomization (MR) studies on 25-hydroxyvitamin D (25(OH)D) and cancer have typically adopted a handful of variants and found no relationship between 25(OH)D and cancer; however, issues of horizontal pleiotropy cannot be reliably address ... Full text Link to item Cite

Targeting Dormant Ovarian Cancer Cells In Vitro and in an In Vivo Mouse Model of Platinum Resistance.

Journal Article Molecular cancer therapeutics · January 2021 Spheroids exhibit drug resistance and slow proliferation, suggesting involvement in cancer recurrence. The protein kinase C inhibitor UCN-01 (7-hydroxystaurosporine) has shown higher efficacy against slow proliferating and/or quiescent ovarian cancer cells ... Full text Cite

Cross-Cancer Genome-Wide Association Study of Endometrial Cancer and Epithelial Ovarian Cancer Identifies Genetic Risk Regions Associated with Risk of Both Cancers.

Journal Article Cancer Epidemiol Biomarkers Prev · January 2021 BACKGROUND: Accumulating evidence suggests a relationship between endometrial cancer and ovarian cancer. Independent genome-wide association studies (GWAS) for endometrial cancer and ovarian cancer have identified 16 and 27 risk regions, respectively, four ... Full text Link to item Cite

Results and Clinical Utilization of Foundation Medicine Molecular Tumor Profiling in Uterine and Ovarian Cancers.

Journal Article Target Oncol · January 2021 BACKGROUND: Recent advances in next-generation sequencing have allowed for an increase in molecular tumor profiling. OBJECTIVE: We sought to assess the actionability and clinical utilization of molecular tumor profiling results obtained via Foundation Medi ... Full text Link to item Cite

Epigenetic Regulation of Claudin-1 in the Development of Ovarian Cancer Recurrence and Drug Resistance.

Journal Article Frontiers in oncology · January 2021 Over 21,000 women are diagnosed with ovarian cancer (OC) in the United States each year and over half that number succumb to this disease annually, often due to recurrent disease. A deeper understanding of the molecular events associated with recurrent dis ... Full text Open Access Cite

Cost-effectiveness analysis comparing "PARP inhibitors-for-all" to the biomarker-directed use of PARP inhibitor maintenance therapy for newly diagnosed advanced stage ovarian cancer.

Journal Article Gynecol Oncol · November 2020 OBJECTIVES: Clinical trials evaluating universal PARP inhibitor (PARPi) frontline maintenance therapy for advanced stage ovarian cancer have reported progression-free survival (PFS) benefit. It is unclear whether PARPi maintenance therapy will universally ... Full text Link to item Cite

Offspring sex and risk of epithelial ovarian cancer: a multinational pooled analysis of 12 case-control studies.

Journal Article Eur J Epidemiol · November 2020 While childbearing protects against risk of epithelial ovarian cancer (EOC), few studies have explored the impact on maternal EOC risk of sex of offspring, which may affect the maternal environment during pregnancy. We performed a pooled analysis among par ... Full text Link to item Cite

Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE).

Journal Article Clin Cancer Res · October 15, 2020 PURPOSE: Gene expression-based molecular subtypes of high-grade serous tubo-ovarian cancer (HGSOC), demonstrated across multiple studies, may provide improved stratification for molecularly targeted trials. However, evaluation of clinical utility has been ... Full text Link to item Cite

Management of high, moderate, and low penetrance ovarian cancer susceptibility mutations: an assessment of current risk reduction practices.

Journal Article Int J Gynecol Cancer · October 2020 OBJECTIVE: Limited information exists regarding risk reduction strategies for women with moderate and low penetrance ovarian cancer susceptibility mutations. We sought to assess current risk reduction practice patterns for carriers of these mutations throu ... Full text Link to item Cite

Menopausal hormone therapy prior to the diagnosis of ovarian cancer is associated with improved survival.

Journal Article Gynecol Oncol · September 2020 PURPOSE: Prior studies of menopausal hormone therapy (MHT) and ovarian cancer survival have been limited by lack of hormone regimen detail and insufficient sample sizes. To address these limitations, a comprehensive analysis of 6419 post-menopausal women w ... Full text Link to item Cite

Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers.

Journal Article Nat Commun · July 3, 2020 Genome-wide association studies (GWAS) have led to the identification of hundreds of susceptibility loci across cancers, but the impact of further studies remains uncertain. Here we analyse summary-level data from GWAS of European ancestry across fourteen ... Full text Link to item Cite

Identification of novel epithelial ovarian cancer loci in women of African ancestry.

Journal Article Int J Cancer · June 1, 2020 Women of African ancestry have lower incidence of epithelial ovarian cancer (EOC) yet worse survival compared to women of European ancestry. We conducted a genome-wide association study in African ancestry women with 755 EOC cases, including 537 high-grade ... Full text Link to item Cite

Estrogen Plus Progestin Hormone Therapy and Ovarian Cancer: A Complicated Relationship Explored.

Journal Article Epidemiology · May 2020 BACKGROUND: Menopausal estrogen-alone therapy is a risk factor for endometrial and ovarian cancers. When a progestin is included with the estrogen daily (continuous estrogen-progestin combined therapy), there is no increased risk of endometrial cancer. How ... Full text Link to item Cite

Intraperitoneal chemotherapy following neoadjuvant chemotherapy and optimal interval tumor reductive surgery for advanced ovarian cancer.

Journal Article Gynecol Oncol · March 2020 OBJECTIVES: Intraperitoneal (IP) chemotherapy following neoadjuvant chemotherapy (NACT) and interval tumor reductive surgery (TRS) for advanced ovarian cancer is feasible, however, the impact on disease outcomes remains unclear. We compare outcomes of pati ... Full text Link to item Cite

Pan-cancer analysis of whole genomes.

Journal Article Nature · February 2020 Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1-3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matchin ... Full text Link to item Cite

The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.

Journal Article J Alzheimers Dis · 2020 BACKGROUND: Perioperative neurocognitive disorders (PND) are common complications in older adults associated with increased 1-year mortality and long-term cognitive decline. One risk factor for worsened long-term postoperative cognitive trajectory is the A ... Full text Open Access Link to item Cite

Patient preferences for attributes of primary surgical debulking versus neoadjuvant chemotherapy for treatment of newly diagnosed ovarian cancer.

Journal Article Cancer · December 15, 2019 BACKGROUND: Randomized trials have reported conflicting findings on survival for advanced-stage ovarian cancer treated with primary debulking surgery (PDS) versus neoadjuvant chemotherapy with interval debulking; surgical complications and mortality are hi ... Full text Link to item Cite

Patient Preferences for Attributes of Primary Surgical Debulking Versus Neoadjuvant Chemotherapy for Treatment of Newly Diagnosed Ovarian Cancer

Journal Article Obstetrical and Gynecological Survey · December 1, 2019 Full text Cite

Publisher Correction: Shared heritability and functional enrichment across six solid cancers.

Journal Article Nat Commun · September 23, 2019 An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Full text Link to item Cite

NCCN Guidelines Insights: Ovarian Cancer, Version 1.2019.

Journal Article J Natl Compr Canc Netw · August 1, 2019 Epithelial ovarian cancer is the leading cause of death from gynecologic cancer in the United States, with less than half of patients living >5 years from diagnosis. A major challenge in treating ovarian cancer is that most patients have advanced disease a ... Full text Link to item Cite

Constitutively active ESR1 mutations in gynecologic malignancies and clinical response to estrogen-receptor directed therapies.

Journal Article Gynecol Oncol · July 2019 OBJECTIVE: Endocrine therapy is often considered as a treatment for hormone-responsive gynecologic malignancies. In breast cancer, activating mutations in the estrogen receptor (mutESR1) contribute to therapeutic resistance to endocrine therapy, especially ... Full text Link to item Cite

Going to extremes: determinants of extraordinary response and survival in patients with cancer.

Journal Article Nat Rev Cancer · June 2019 Research into factors affecting treatment response or survival in patients with cancer frequently involves cohorts that span the most common range of clinical outcomes, as such patients are most readily available for study. However, attention has turned to ... Full text Link to item Cite

Association between genetically predicted polycystic ovary syndrome and ovarian cancer: a Mendelian randomization study.

Journal Article Int J Epidemiol · June 1, 2019 BACKGROUND: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder with an estimated prevalence of 4-21% in reproductive aged women. Recently, the Ovarian Cancer Association Consortium (OCAC) reported a decreased risk of invasive ovarian cancer a ... Full text Link to item Cite

Management of high, moderate, and low penetrance ovarian cancer susceptibility gene mutations: An assessment of current practice patterns.

Conference Journal of Clinical Oncology · May 20, 2019 1536 Background: Limited information exists regarding appropriate risk-reduction strategies for women with moderate and low penetrance ovarian cancer (OVCA) susceptibility mutations. We sought to assess current practice patterns ... Full text Cite

Associations between lymphovascular space invasion, nodal recurrence, and survival in patients with surgical stage I endometrioid endometrial adenocarcinoma.

Journal Article World J Surg Oncol · May 10, 2019 OBJECTIVE: To investigate the predictive value of lymphovascular space invasion (LVSI) for nodal recurrence and overall survival (OS) in patients with stage I endometrioid endometrial cancer (EC) following surgical staging that included adequate lymph node ... Full text Link to item Cite

A comprehensive gene-environment interaction analysis in Ovarian Cancer using genome-wide significant common variants.

Journal Article Int J Cancer · May 1, 2019 As a follow-up to genome-wide association analysis of common variants associated with ovarian carcinoma (cancer), our study considers seven well-known ovarian cancer risk factors and their interactions with 28 genome-wide significant common genetic variant ... Full text Link to item Cite

Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women.

Journal Article Gynecol Oncol · May 2019 OBJECTIVE: Genome-wide association studies (GWASs) for epithelial ovarian cancer (EOC) have focused largely on populations of European ancestry. We aimed to identify common germline variants associated with EOC risk in Asian women. METHODS: Genotyping was ... Full text Open Access Link to item Cite

A pilot study of lower extremity lymphedema, lower extremity function, and quality of life in women after minimally invasive endometrial cancer staging surgery.

Journal Article Gynecol Oncol · May 2019 OBJECTIVE: The primary aim of this study was to pilot the use of an objective measurement technique to prospectively evaluate the incidence of lower extremity lymphedema (LEL) after minimally invasive staging surgery for endometrial cancer. Secondary objec ... Full text Link to item Cite

Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women.

Journal Article Cancer Med · May 2019 An association between genetic variants in the vitamin D receptor (VDR) gene and epithelial ovarian cancer (EOC) was previously reported in women of African ancestry (AA). We sought to examine associations between genetic variants in VDR and additional gen ... Full text Link to item Cite

The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.

Journal Article J Am Geriatr Soc · April 2019 BACKGROUND/OBJECTIVES: Every year, up to 40% of the more than 16 million older Americans who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD) or delirium. Each of these distinct syndromes is associated with decreased quality of ... Full text Open Access Link to item Cite

Clinicopathologic and Molecular Characteristics of Copy-Number Low Endometrial Adenocarcinomas

Conference MODERN PATHOLOGY · March 1, 2019 Link to item Cite

Clinicopathologic and Molecular Characteristics of Copy-Number Low Endometrial Adenocarcinomas

Conference LABORATORY INVESTIGATION · March 1, 2019 Link to item Cite

Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk.

Journal Article Cancer Res · February 1, 2019 DNA methylation is instrumental for gene regulation. Global changes in the epigenetic landscape have been recognized as a hallmark of cancer. However, the role of DNA methylation in epithelial ovarian cancer (EOC) remains unclear. In this study, high-densi ... Full text Link to item Cite

Functional Analysis and Fine Mapping of the 9p22.2 Ovarian Cancer Susceptibility Locus.

Journal Article Cancer Res · February 1, 2019 Genome-wide association studies have identified 40 ovarian cancer risk loci. However, the mechanisms underlying these associations remain elusive. In this study, we conducted a two-pronged approach to identify candidate causal SNPs and assess underlying bi ... Full text Link to item Cite

Shared heritability and functional enrichment across six solid cancers.

Journal Article Nat Commun · January 25, 2019 Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 con ... Full text Link to item Cite

Invasive Epithelial Ovarian Cancer Survival by Histotype and Disease Stage.

Journal Article J Natl Cancer Inst · January 1, 2019 BACKGROUND: The understanding of ovarian cancer pathogenesis has recently shifted to recognize distinct changes in how ovarian cancer histotypes are defined. Using the 2014 World Health Organization (WHO) diagnostic guidelines, we classified ovarian cancer ... Full text Link to item Cite

Role of surgery in cancer prevention

Chapter · November 16, 2018 Cite

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer.

Journal Article Cell Rep · October 30, 2018 Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehensive molecular characterization of 19 Hippo core genes in 9,125 tumor samples across 33 cancer types using multidimensional "omic" data from The Cancer Genom ... Full text Link to item Cite

A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily.

Journal Article Cell Syst · October 24, 2018 We present an integromic analysis of gene alterations that modulate transforming growth factor β (TGF-β)-Smad-mediated signaling in 9,125 tumor samples across 33 cancer types in The Cancer Genome Atlas (TCGA). Focusing on genes that encode mediators and re ... Full text Link to item Cite

Association of p16 expression with prognosis varies across ovarian carcinoma histotypes: an Ovarian Tumor Tissue Analysis consortium study.

Journal Article J Pathol Clin Res · October 2018 We aimed to validate the prognostic association of p16 expression in ovarian high-grade serous carcinomas (HGSC) and to explore it in other ovarian carcinoma histotypes. p16 protein expression was assessed by clinical-grade immunohistochemistry in 6525 ova ... Full text Link to item Cite

Histotype classification of ovarian carcinoma: A comparison of approaches.

Journal Article Gynecol Oncol · October 2018 OBJECTIVE: Major changes in the classification of ovarian carcinoma histotypes occurred over the last two decades, resulting in the current 2014 World Health Organization (WHO) diagnostic criteria that recognize five principal histotypes: high-grade serous ... Full text Link to item Cite

A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk.

Journal Article Cancer Res · September 15, 2018 Large-scale genome-wide association studies (GWAS) have identified approximately 35 loci associated with epithelial ovarian cancer (EOC) risk. The majority of GWAS-identified disease susceptibility variants are located in noncoding regions, and causal gene ... Full text Link to item Cite

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients.

Journal Article Cancer Cell · August 13, 2018 Our comprehensive analysis of alternative splicing across 32 The Cancer Genome Atlas cancer types from 8,705 patients detects alternative splicing events and tumor variants by reanalyzing RNA and whole-exome sequencing data. Tumors have up to 30% more alte ... Full text Link to item Cite

Comprehensive Characterization of Cancer Driver Genes and Mutations.

Journal Article Cell · August 9, 2018 Full text Link to item Cite

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma.

Journal Article Cell Rep · June 19, 2018 Full text Link to item Cite

Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies.

Journal Article Int J Epidemiol · June 1, 2018 Full text Link to item Cite

The importance of using public data to validate reported associations.

Journal Article PLoS Genet · June 2018 Full text Link to item Cite

Assessment of activating estrogen receptor 1 (ESR1) mutations in gynecologic malignancies.

Conference Journal of Clinical Oncology · May 20, 2018 Full text Cite

A gene expression prognostic signature for overall survival in patients with high-grade serous ovarian cancer.

Conference Journal of Clinical Oncology · May 20, 2018 Full text Cite

Prospective Evaluation of Lymph Node Processing at Staging Surgery for High-grade Endometrial Cancer.

Journal Article Int J Gynecol Pathol · May 2018 To determine whether the processing of additional adipose tissue collected during lymph node (LN) dissection results in the identification of additional LNs during endometrial cancer (EC) staging and to determine if the division of LNs into nodal basin-spe ... Full text Link to item Cite

The Immune Landscape of Cancer.

Journal Article Immunity · April 17, 2018 We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified six immune subtypes-wound healing, IFN-γ dominant, inflammatory, lymphocyt ... Full text Link to item Cite

Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas.

Journal Article Cancer Cell · April 9, 2018 We analyzed 921 adenocarcinomas of the esophagus, stomach, colon, and rectum to examine shared and distinguishing molecular characteristics of gastrointestinal tract adenocarcinomas (GIACs). Hypermutated tumors were distinct regardless of cancer type and c ... Full text Link to item Cite

lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer.

Journal Article Cancer Cell · April 9, 2018 We characterized the epigenetic landscape of genes encoding long noncoding RNAs (lncRNAs) across 6,475 tumors and 455 cancer cell lines. In stark contrast to the CpG island hypermethylation phenotype in cancer, we observed a recurrent hypomethylation of 1, ... Full text Link to item Cite

Genomic and Functional Approaches to Understanding Cancer Aneuploidy.

Journal Article Cancer Cell · April 9, 2018 Aneuploidy, whole chromosome or chromosome arm imbalance, is a near-universal characteristic of human cancers. In 10,522 cancer genomes from The Cancer Genome Atlas, aneuploidy was correlated with TP53 mutation, somatic mutation rate, and expression of pro ... Full text Link to item Cite

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers.

Journal Article Cancer Cell · April 9, 2018 We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of four gynecological types plus breast. Our aims were to identify shared and unique molecular features, clinically significant subtypes, and potential therapeutic targets. We f ... Full text Link to item Cite

Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.

Journal Article Cell · April 5, 2018 The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of diverse genomic alterations underlying human cancers. At this historic junction marking the completion of genomic characterization of over 11,000 tumors from 33 cancer types, we pr ... Full text Link to item Cite

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.

Journal Article Cell · April 5, 2018 We conducted comprehensive integrative molecular analyses of the complete set of tumors in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and representing 33 types of cancer. We performed molecular clustering using data on chr ... Full text Link to item Cite

Pathogenic Germline Variants in 10,389 Adult Cancers.

Journal Article Cell · April 5, 2018 We conducted the largest investigation of predisposition variants in cancer to date, discovering 853 pathogenic or likely pathogenic variants in 8% of 10,389 cases from 33 cancer types. Twenty-one genes showed single or cross-cancer associations, including ... Full text Link to item Cite

A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples.

Journal Article Cell · April 5, 2018 The role of enhancers, a key class of non-coding regulatory DNA elements, in cancer development has increasingly been appreciated. Here, we present the detection and characterization of a large number of expressed enhancers in a genome-wide analysis of 892 ... Full text Link to item Cite

Oncogenic Signaling Pathways in The Cancer Genome Atlas.

Journal Article Cell · April 5, 2018 Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tu ... Full text Link to item Cite

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation.

Journal Article Cell · April 5, 2018 Cancer progression involves the gradual loss of a differentiated phenotype and acquisition of progenitor and stem-cell-like features. Here, we provide novel stemness indices for assessing the degree of oncogenic dedifferentiation. We used an innovative one ... Full text Link to item Cite

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics.

Journal Article Cell · April 5, 2018 For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features represe ... Full text Link to item Cite

Comprehensive Characterization of Cancer Driver Genes and Mutations.

Journal Article Cell · April 5, 2018 Identifying molecular cancer drivers is critical for precision oncology. Multiple advanced algorithms to identify drivers now exist, but systematic attempts to combine and optimize them on large datasets are few. We report a PanCancer and PanSoftware analy ... Full text Link to item Cite

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma.

Journal Article Cell Rep · April 3, 2018 Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, includ ... Full text Link to item Cite

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context.

Journal Article Cell Rep · April 3, 2018 Long noncoding RNAs (lncRNAs) are commonly dysregulated in tumors, but only a handful are known to play pathophysiological roles in cancer. We inferred lncRNAs that dysregulate cancer pathways, oncogenes, and tumor suppressors (cancer genes) by modeling th ... Full text Link to item Cite

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.

Journal Article Cell Rep · April 3, 2018 Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% validation ra ... Full text Link to item Cite

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images.

Journal Article Cell Rep · April 3, 2018 Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumor-infiltrating lymphocytes (TILs) based on H&E images from 13 TCGA t ... Full text Link to item Cite

Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers.

Journal Article Cell Rep · April 3, 2018 Metabolic reprogramming provides critical information for clinical oncology. Using molecular data of 9,125 patient samples from The Cancer Genome Atlas, we identified tumor subtypes in 33 cancer types based on mRNA expression patterns of seven major metabo ... Full text Link to item Cite

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas.

Journal Article Cell Rep · April 3, 2018 This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smoking and/or human papillomavirus (HPV). SCCs harbor 3q, 5p, and other recu ... Full text Link to item Cite

Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types.

Journal Article Cell Rep · April 3, 2018 Protein ubiquitination is a dynamic and reversible process of adding single ubiquitin molecules or various ubiquitin chains to target proteins. Here, using multidimensional omic data of 9,125 tumor samples across 33 cancer types from The Cancer Genome Atla ... Full text Link to item Cite

Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas.

Journal Article Cell Rep · April 3, 2018 Precision oncology uses genomic evidence to match patients with treatment but often fails to identify all patients who may respond. The transcriptome of these "hidden responders" may reveal responsive molecular states. We describe and evaluate a machine-le ... Full text Link to item Cite

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types.

Journal Article Cell Rep · April 3, 2018 Hotspot mutations in splicing factor genes have been recently reported at high frequency in hematological malignancies, suggesting the importance of RNA splicing in cancer. We analyzed whole-exome sequencing data across 33 tumor types in The Cancer Genome ... Full text Link to item Cite

Systematic Analysis of Splice-Site-Creating Mutations in Cancer.

Journal Article Cell Rep · April 3, 2018 For the past decade, cancer genomic studies have focused on mutations leading to splice-site disruption, overlooking those having splice-creating potential. Here, we applied a bioinformatic tool, MiSplice, for the large-scale discovery of splice-site-creat ... Full text Link to item Cite

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas.

Journal Article Cell Rep · April 3, 2018 DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types. Mutations with accompanying loss of heter ... Full text Link to item Cite

Common Genetic Variation and Susceptibility to Ovarian Cancer: Current Insights and Future Directions.

Journal Article Cancer Epidemiol Biomarkers Prev · April 2018 In this review, we summarize current progress in the genetic epidemiology of epithelial ovarian cancer (EOC), focusing exclusively on elucidating the role of common germline genetic variation in conferring susceptibility to EOC. We provide an overview of t ... Full text Link to item Cite

Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies.

Journal Article Int J Epidemiol · April 1, 2018 BACKGROUND: Ovarian cancer incidence differs substantially by race/ethnicity, but the reasons for this are not well understood. Data were pooled from the African American Cancer Epidemiology Study (AACES) and 11 case-control studies in the Ovarian Cancer A ... Full text Link to item Cite

Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study.

Journal Article Br J Cancer · April 2018 BACKGROUND: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bia ... Full text Link to item Cite

Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study.

Journal Article Int J Epidemiol · April 1, 2018 BACKGROUND: Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations ar ... Full text Link to item Cite

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas.

Journal Article Cell Syst · March 28, 2018 Although the MYC oncogene has been implicated in cancer, a systematic assessment of alterations of MYC, related transcription factors, and co-regulatory proteins, forming the proximal MYC network (PMN), across human cancers is lacking. Using computational ... Full text Link to item Cite

Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines.

Journal Article Cell Syst · March 28, 2018 The Cancer Genome Atlas (TCGA) cancer genomics dataset includes over 10,000 tumor-normal exome pairs across 33 different cancer types, in total >400 TB of raw data files requiring analysis. Here we describe the Multi-Center Mutation Calling in Multiple Can ... Full text Link to item Cite

Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence.

Journal Article Am J Epidemiol · February 1, 2018 There have been recent proposals advocating the use of additive gene-environment interaction instead of the widely used multiplicative scale, as a more relevant public health measure. Using gene-environment independence enhances statistical power for testi ... Full text Link to item Cite

Menstrual pain and risk of epithelial ovarian cancer: Results from the Ovarian Cancer Association Consortium.

Journal Article Int J Cancer · February 1, 2018 Menstrual pain, a common gynecological condition, has been associated with increased risk of ovarian cancer in some, but not all studies. Furthermore, potential variations in the association between menstrual pain and ovarian cancer by histologic subtype h ... Full text Link to item Cite

Polycystic Ovary Syndrome, Oligomenorrhea, and Risk of Ovarian Cancer Histotypes: Evidence from the Ovarian Cancer Association Consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · February 2018 Background: Polycystic ovary syndrome (PCOS), and one of its distinguishing characteristics, oligomenorrhea, have both been associated with ovarian cancer risk in some but not all studies. However, these associations have been rarely examined by ovarian ca ... Full text Link to item Cite

Estimating Cost-effectiveness of a Multimodal Ovarian Cancer Screening Program in the United States: Secondary Analysis of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS).

Journal Article JAMA Oncol · February 1, 2018 IMPORTANCE: The United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) is the largest randomized clinical trial to evaluate screening's impact on ovarian cancer mortality, assigning women to multimodal screening (MMS) with serum cancer an ... Full text Link to item Cite

Urinary diversion in the genitourinary cancer survivor.

Journal Article Gynecol Oncol · February 2018 Urinary diversion has been in the scope of practice of Gynecologic Oncologists since the inception of the sub-specialty. However, many fewer urinary diversions are performed currently than in the past due to improved prevention of cervical cancer. The inte ... Full text Link to item Cite

Ovarian cancer risk, ALDH2 polymorphism and alcohol drinking: Asian data from the Ovarian Cancer Association Consortium.

Journal Article Cancer Sci · February 2018 The aldehyde dehydrogenase 2 (ALDH2) polymorphism rs671 (Glu504Lys) causes ALDH2 inactivation and adverse acetaldehyde exposure among Asians, but little is known of the association between alcohol consumption and rs671 and ovarian cancer (OvCa) in Asians. ... Full text Link to item Cite

Maintenance Poly (ADP-ribose) Polymerase Inhibitor Therapy for Ovarian Cancer: Precision Oncology or One Size Fits All?

Journal Article J Clin Oncol · December 20, 2017 Full text Link to item Cite

Genome-wide association study evaluating single-nucleotide polymorphisms and outcomes in patients with advanced stage serous ovarian or primary peritoneal cancer: An NRG Oncology/Gynecologic Oncology Group study.

Journal Article Gynecol Oncol · November 2017 OBJECTIVE: This study evaluated single nucleotide polymorphisms (SNPs) associated with progression free (PFS) and overall survival (OS) in patients with advanced stage serous EOC. METHODS: Patients enrolled in GOG-172 and 182 who provided specimens for tra ... Full text Link to item Cite

Race-specific molecular alterations correlate with differential outcomes for black and white endometrioid endometrial cancer patients.

Journal Article Cancer · October 15, 2017 BACKGROUND: The objective of this study was to identify molecular alterations associated with disease outcomes for white and black patients with endometrioid endometrial cancer (EEC). METHODS: EEC samples from black (n = 17) and white patients (n = 13) wer ... Full text Link to item Cite

Analyses of germline variants associated with ovarian cancer survival identify functional candidates at the 1q22 and 19p12 outcome loci.

Journal Article Oncotarget · September 12, 2017 We previously identified associations with ovarian cancer outcome at five genetic loci. To identify putatively causal genetic variants and target genes, we prioritized two ovarian outcome loci (1q22 and 19p12) for further study. Bioinformatic and functiona ... Full text Link to item Cite

Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors.

Journal Article Nat Med · September 2017 It is generally assumed that recurrent mutations within a given cancer driver gene elicit similar drug responses. Cancer genome studies have identified recurrent but divergent missense mutations affecting the substrate-recognition domain of the ubiquitin l ... Full text Link to item Cite

Early Detection of Ovarian Cancer using the Risk of Ovarian Cancer Algorithm with Frequent CA125 Testing in Women at Increased Familial Risk - Combined Results from Two Screening Trials.

Journal Article Clin Cancer Res · July 15, 2017 Purpose: Women at familial/genetic ovarian cancer risk often undergo screening despite unproven efficacy. Research suggests each woman has her own CA125 baseline; significant increases above this level may identify cancers earlier than standard 6- to 12-mo ... Full text Link to item Cite

The hereditary nature of small cell carcinoma of the ovary, hypercalcemic type: two new familial cases.

Journal Article Fam Cancer · July 2017 Small cell carcinoma of the ovary, hypercalcemic type, (SCCOHT) is the most common undifferentiated ovarian cancer in women aged under 40 years. SCCOHT is a monogenic disease, characterized by germline and somatic SMARCA4 mutations. Recent studies have str ... Full text Link to item Cite

RE: “RISK PREDICTION FOR EPITHELIAL OVARIAN CANCER IN 11 UNITED STATES–BASED CASE-CONTROL STUDIES: INCORPORATION OF EPIDEMIOLOGIC RISK FACTORS AND 17 CONFIRMED GENETIC LOCI”

Journal Article American Journal of Epidemiology · July 1, 2017 Full text Cite

Abstract 1289: Evaluation of vitamin D receptor regulated genes reveals EGFR polymorphism is associated with high-grade serous ovarian cancer in African American women

Conference Cancer Research · July 1, 2017 AbstractFew studies have evaluated genetic risk factors for ovarian cancer in African American women. In a previous study with small sample sizes, Vitamin D Receptor (VDR) variants were shown to increase ris ... Full text Cite

Abstract 1991: Enhanced role of the extracellular matrix in ovarian cancer recurrence

Conference Cancer Research · July 1, 2017 AbstractPurpose: Despite improvements in care and advancements in the understanding of ovarian cancer (OC) pathobiology and genetic alterations, the survival rate is disappointingly low when compared to that ... Full text Cite

Analyses of germline variants associated with ovarian cancer survival identify functional candidates at the 1q22 and 19p12 outcome loci.

Journal Article Oncotarget · June 15, 2017 We previously identified associations with ovarian cancer outcome at five genetic loci. To identify putatively causal genetic variants and target genes, we prioritized two ovarian outcome loci (1q22 and 19p12) for further study. Bioinformatic and functiona ... Full text Link to item Cite

Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies.

Journal Article Int J Cancer · June 1, 2017 Cigarette smoking is associated with an increased risk of developing mucinous ovarian tumors but whether it is associated with ovarian cancer survival overall or for the different histotypes is unestablished. Furthermore, it is unknown whether the associat ... Full text Link to item Cite

Cost-effectiveness of ovarian cancer screening: An analysis of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) from a U.S. health system perspective.

Conference Journal of Clinical Oncology · May 20, 2017 6608 Background: UKCTOCS is the largest randomized controlled trial to evaluate screening’s impact on ovarian cancer mortality, assigning women to multimodal screening (MMS) with serum CA125 interpreted with a risk algorithm; ann ... Full text Cite

Evaluating the repertoire of immune checkpoint markers expressed on peripheral and ascites CD8⁺ T cells in ovarian cancer.

Conference Journal of Clinical Oncology · May 20, 2017 5571 Background: Understanding the immune checkpoint marker repertoire can facilitate development of therapeutic strategies to improve efficacy of immune-based therapies. We used a novel high-dimensional flow cytometry panel to d ... Full text Cite

History of hypertension, heart disease, and diabetes and ovarian cancer patient survival: evidence from the ovarian cancer association consortium.

Journal Article Cancer Causes Control · May 2017 PURPOSE: Survival following ovarian cancer diagnosis is generally low; understanding factors related to prognosis could be important to optimize treatment. The role of previously diagnosed comorbidities and use of medications for those conditions in relati ... Full text Link to item Cite

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.

Journal Article Nat Genet · May 2017 To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for d ... Full text Link to item Cite

Is There a Role for Ovarian Cancer Screening in High-Risk Women?

Journal Article J Clin Oncol · May 1, 2017 Full text Link to item Cite

Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium.

Journal Article Br J Cancer · April 25, 2017 BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with improved survival in some cancers, but evidence for ovarian cancer is limited. METHODS: Pooling individual-level data from 12 Ovarian Cancer Association Consortium studies, ... Full text Link to item Cite

Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer.

Journal Article BMC Genomics · March 31, 2017 BACKGROUND: Epigenetic information can be used to identify clinically relevant genomic variants single nucleotide polymorphisms (SNPs) of functional importance in cancer development. Super-enhancers are cell-specific DNA elements, acting to determine tissu ... Full text Link to item Cite

No Evidence That Genetic Variation in the Myeloid-Derived Suppressor Cell Pathway Influences Ovarian Cancer Survival.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2017 Background: The precise mechanism by which the immune system is adversely affected in cancer patients remains poorly understood, but the accumulation of immunosuppressive/protumorigenic myeloid-derived suppressor cells (MDSCs) is thought to be a prominent ... Full text Link to item Cite

Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci.

Journal Article Br J Cancer · February 14, 2017 BACKGROUND: Genome-wide association studies (GWAS) have identified 18 loci associated with serous ovarian cancer (SOC) susceptibility but the biological mechanisms driving these findings remain poorly characterised. Germline cancer risk loci may be enriche ... Full text Link to item Cite

The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers.

Journal Article Cancer Epidemiol Biomarkers Prev · January 2017 BACKGROUND: Common cancers develop through a multistep process often including inherited susceptibility. Collaboration among multiple institutions, and funding from multiple sources, has allowed the development of an inexpensive genotyping microarray, the ... Full text Link to item Cite

Pelvic Inflammatory Disease and the Risk of Ovarian Cancer and Borderline Ovarian Tumors: A Pooled Analysis of 13 Case-Control Studies.

Journal Article Am J Epidemiol · January 1, 2017 Inflammation has been implicated in ovarian carcinogenesis. However, studies investigating the association between pelvic inflammatory disease (PID) and ovarian cancer risk are few and inconsistent. We investigated the association between PID and the risk ... Full text Link to item Cite

Integration of Population-Level Genotype Data with Functional Annotation Reveals Over-Representation of Long Noncoding RNAs at Ovarian Cancer Susceptibility Loci.

Journal Article Cancer Epidemiol Biomarkers Prev · January 2017 BACKGROUND: Genome-wide association studies (GWAS) have identified multiple loci associated with epithelial ovarian cancer (EOC) susceptibility, but further progress requires integration of epidemiology and biology to illuminate true risk loci below genome ... Full text Link to item Cite

A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer.

Journal Article Int J Cancer · December 15, 2016 Menopausal estrogen-alone therapy (ET) is a well-established risk factor for serous and endometrioid ovarian cancer. Genetics also plays a role in ovarian cancer, which is partly attributable to 18 confirmed ovarian cancer susceptibility loci identified by ... Full text Link to item Cite

Telomere structure and maintenance gene variants and risk of five cancer types.

Journal Article Int J Cancer · December 15, 2016 Telomeres cap chromosome ends, protecting them from degradation, double-strand breaks, and end-to-end fusions. Telomeres are maintained by telomerase, a reverse transcriptase encoded by TERT, and an RNA template encoded by TERC. Loci in the TERT and adjoin ... Full text Link to item Cite

PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.

Journal Article J Med Genet · December 2016 BACKGROUND: The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some of these mutations are associated with breast cancer risk ... Full text Link to item Cite

Stress and burnout among gynecologic oncologists: A society of gynecologic oncology evidence-based review and recommendations

Journal Article Obstetrical and Gynecological Survey · December 1, 2016 Full text Cite

Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility: results from a large-scale collaboration.

Journal Article Oncotarget · November 8, 2016 RNA editing in mammals is a form of post-transcriptional modification in which adenosine is converted to inosine by the adenosine deaminases acting on RNA (ADAR) family of enzymes. Based on evidence of altered ADAR expression in epithelial ovarian cancers ... Full text Link to item Cite

Stress and burnout among gynecologic oncologists: A Society of Gynecologic Oncology Evidence-based Review and Recommendations.

Journal Article Gynecol Oncol · November 2016 Full text Link to item Cite

Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.

Journal Article Oncotarget · October 25, 2016 BACKGROUND: Regulatory T (Treg) cells, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and, thus, variants in genes encoding Treg cell immune molecules could be associated with ovarian cancer. METHODS: In a population of 15,59 ... Full text Link to item Cite

Risk Prediction for Epithelial Ovarian Cancer in 11 United States-Based Case-Control Studies: Incorporation of Epidemiologic Risk Factors and 17 Confirmed Genetic Loci.

Journal Article Am J Epidemiol · October 15, 2016 Previously developed models for predicting absolute risk of invasive epithelial ovarian cancer have included a limited number of risk factors and have had low discriminatory power (area under the receiver operating characteristic curve (AUC) < 0.60). Becau ... Full text Open Access Link to item Cite

Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study.

Journal Article Int J Epidemiol · October 2016 BACKGROUND: In vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention. However, the relationship between vitamin D and ovarian cancer is uncertain, with observational studies generating conflicting findi ... Full text Link to item Cite

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.

Journal Article Nat Commun · September 7, 2016 A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associat ... Full text Link to item Cite

Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types.

Journal Article Cancer Discov · September 2016 UNLABELLED: Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis dat ... Full text Link to item Cite

Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium

Journal Article Obstetrical and Gynecological Survey · September 1, 2016 Full text Cite

Evaluating the Repertoire of Immune Checkpoint Markers Expressed Within Ovarian Cancers

Journal Article JOURNAL OF WOMENS HEALTH · September 1, 2016 Link to item Cite

Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk.

Journal Article Hum Mol Genet · August 15, 2016 Rare and low frequency variants are not well covered in most germline genotyping arrays and are understudied in relation to epithelial ovarian cancer (EOC) risk. To address this gap, we used genotyping arrays targeting rarer protein-coding variation in 8,1 ... Full text Link to item Cite

Performance of sentinel lymph node biopsy in high-risk endometrial cancer.

Journal Article Gynecol Oncol Rep · August 2016 OBJECTIVE: To determine the rate and performance of sentinel lymph node (SLN) mapping among women with high-risk endometrial cancers. METHODS: Patients diagnosed between 2012 and 2015 with uterine cancer of grade 3 endometrioid, clear cell, serous or carci ... Full text Link to item Cite

Association between menopausal estrogen-only therapy and ovarian carcinoma risk

Journal Article Obstetrical and Gynecological Survey · August 1, 2016 Full text Cite

Abstract 3407: Gene expression subtypes of high grade serous ovarian cancer in African American women

Conference Cancer Research · July 15, 2016 AbstractOvarian cancer accounts for 5% of cancer deaths and is the fifth leading cause of cancer death in women in the United States. While incidence is higher in European American (EA) than African American ... Full text Cite

Abstract 797: A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer

Conference Cancer Research · July 15, 2016 AbstractMenopausal estrogen-alone therapy (ET) is a well-established risk factor for serous and endometrioid ovarian carcinoma. Genetics also plays an important role in ovarian carcinoma etiology, which is p ... Full text Cite

Assessing the genetic architecture of epithelial ovarian cancer histological subtypes.

Journal Article Hum Genet · July 2016 Epithelial ovarian cancer (EOC) is one of the deadliest common cancers. The five most common types of disease are high-grade and low-grade serous, endometrioid, mucinous and clear cell carcinoma. Each of these subtypes present distinct molecular pathogenes ... Full text Link to item Cite

Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · July 2016 BACKGROUND: Despite a large body of literature evaluating the association between recreational physical activity and epithelial ovarian cancer (EOC) risk, the extant evidence is inconclusive, and little is known about the independent association between re ... Full text Link to item Cite

Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium.

Journal Article Br J Cancer · June 28, 2016 BACKGROUND: Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between ... Full text Link to item Cite

The Association Between Body Mass Index and Presenting Symptoms in African American Women with Ovarian Cancer.

Journal Article J Womens Health (Larchmt) · June 2016 BACKGROUND: Ovarian cancer, the most lethal gynecologic malignancy, typically comes to clinical attention due to nonspecific gastrointestinal or pelvic symptoms. African Americans with ovarian cancer have a greater mortality burden than whites and are also ... Full text Link to item Cite

The influence of clinical and genetic factors on patient outcome in small cell carcinoma of the ovary, hypercalcemic type.

Journal Article Gynecol Oncol · June 2016 OBJECTIVE: Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is an aggressive tumor, with long term survival at ~30% in early stage disease. SCCOHT is caused by germline and somatic SMARCA4 mutations, but the effect of the mutation type on pat ... Full text Link to item Cite

What Women and Their Physicians Need to Know About the UKCTOCS Study and Ovarian Cancer Screening.

Journal Article Am Fam Physician · June 1, 2016 Link to item Cite

Adult body mass index and risk of ovarian cancer by subtype: a Mendelian randomization study.

Journal Article Int J Epidemiol · June 2016 BACKGROUND: Observational studies have reported a positive association between body mass index (BMI) and ovarian cancer risk. However, questions remain as to whether this represents a causal effect, or holds for all histological subtypes. The lack of assoc ... Full text Link to item Cite

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.

Journal Article Gynecol Oncol · May 2016 OBJECTIVE: Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3' UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. ... Full text Link to item Cite

Assessment of Multifactor Gene-Environment Interactions and Ovarian Cancer Risk: Candidate Genes, Obesity, and Hormone-Related Risk Factors.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2016 BACKGROUND: Many epithelial ovarian cancer (EOC) risk factors relate to hormone exposure and elevated estrogen levels are associated with obesity in postmenopausal women. Therefore, we hypothesized that gene-environment interactions related to hormone-rela ... Full text Link to item Cite

Association Between Menopausal Estrogen-Only Therapy and Ovarian Carcinoma Risk.

Journal Article Obstet Gynecol · May 2016 OBJECTIVE: To describe the association between postmenopausal estrogen-only therapy use and risk of ovarian carcinoma, specifically with regard to disease histotype and duration and timing of use. METHODS: We conducted a pooled analysis of 906 women with o ... Full text Link to item Cite

The association between socioeconomic status and tumour stage at diagnosis of ovarian cancer: A pooled analysis of 18 case-control studies.

Journal Article Cancer Epidemiol · April 2016 PURPOSE: Socioeconomic status (SES) is a known predictor of survival for several cancers and it has been suggested that SES differences affecting tumour stage at diagnosis may be the most important explanatory factor for this. However, only a limited numbe ... Full text Link to item Cite

Subthreshold posttraumatic stress disorder: A meta-analytic review of DSM-IV prevalence and a proposed DSM-5 approach to measurement.

Journal Article Psychol Trauma · March 2016 Subthreshold posttraumatic stress disorder (PTSD) is a chronic condition that is often ignored, the cumulative effects of which can negatively impact an individual's quality of life and overall health care costs. However, subthreshold PTSD prevalence rates ... Full text Link to item Cite

Investigation of Exomic Variants Associated with Overall Survival in Ovarian Cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2016 BACKGROUND: While numerous susceptibility loci for epithelial ovarian cancer (EOC) have been identified, few associations have been reported with overall survival. In the absence of common prognostic genetic markers, we hypothesize that rare coding variant ... Full text Link to item Cite

A targeted genetic association study of epithelial ovarian cancer susceptibility.

Journal Article Oncotarget · February 16, 2016 BACKGROUND: Genome-wide association studies have identified several common susceptibility alleles for epithelial ovarian cancer (EOC). To further understand EOC susceptibility, we examined previously ungenotyped candidate variants, including uncommon varia ... Full text Link to item Cite

Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer.

Journal Article Oncotarget · February 9, 2016 Women with epithelial ovarian cancer (EOC) are usually treated with platinum/taxane therapy after cytoreductive surgery but there is considerable inter-individual variation in response. To identify germline single-nucleotide polymorphisms (SNPs) that contr ... Full text Link to item Cite

Prospective Evaluation of Lymph Node Processing at Staging Surgery for High-Grade Endometrial Cancer

Conference MODERN PATHOLOGY · February 1, 2016 Link to item Cite

BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers.

Other J Natl Cancer Inst · February 2016 BACKGROUND: The K3326X variant in BRCA2 (BRCA2*c.9976A>T; p.Lys3326*; rs11571833) has been found to be associated with small increased risks of breast cancer. However, it is not clear to what extent linkage disequilibrium with fully pathogenic mutations mi ... Full text Link to item Cite

Abstract B27: Investigation of small GTPase genes in epithelial ovarian cancer.

Journal Article Clinical Cancer Research · January 15, 2016 AbstractBackground: Epithelial Ovarian Cancer (EOC) is a lethal gynecologic malignancy and the fifth cause of cancer mortality in women in the US. Normal ovarian physiology is intricately connected to tightl ... Full text Cite

Evidence of a genetic link between endometriosis and ovarian cancer.

Journal Article Fertil Steril · January 2016 OBJECTIVE: To evaluate whether endometriosis-associated genetic variation affects risk of ovarian cancer. DESIGN: Pooled genetic analysis. SETTING: University hospital. PATIENT(S): Genetic data from 46,176 participants (15,361 ovarian cancer cases and 30,8 ... Full text Link to item Cite

Erratum: Common variants at 19p13 are associated with susceptibility to ovarian cancer (Nature Genetics (2010) 42 (880-884))

Journal Article Nature Genetics · December 29, 2015 Full text Cite

Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium.

Journal Article Clin Cancer Res · December 1, 2015 PURPOSE: Chemotherapy resistance remains a major challenge in the treatment of ovarian cancer. We hypothesize that germline polymorphisms might be associated with clinical outcome. EXPERIMENTAL DESIGN: We analyzed approximately 2.8 million genotyped and im ... Full text Link to item Cite

Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk.

Journal Article Genet Epidemiol · December 2015 Epithelial-mesenchymal transition (EMT) is a process whereby epithelial cells assume mesenchymal characteristics to facilitate cancer metastasis. However, EMT also contributes to the initiation and development of primary tumors. Prior studies that explored ... Full text Link to item Cite

Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer.

Journal Article Carcinogenesis · November 2015 Genome-wide association studies have identified 20 genomic regions associated with risk of epithelial ovarian cancer (EOC), but many additional risk variants may exist. Here, we evaluated associations between common genetic variants [single nucleotide poly ... Full text Link to item Cite

A functional variant in HOXA11-AS, a novel long non-coding RNA, inhibits the oncogenic phenotype of epithelial ovarian cancer.

Journal Article Oncotarget · October 27, 2015 The homeobox A (HOXA) region of protein-coding genes impacts female reproductive system embryogenesis and ovarian carcinogenesis. The 5-prime end of HOXA includes three long non-coding RNAs (lncRNAs) (HOXA10-AS, HOXA11-AS, and HOTTIP) that are underexplore ... Full text Link to item Cite

Shared genetics underlying epidemiological association between endometriosis and ovarian cancer.

Journal Article Hum Mol Genet · October 15, 2015 Epidemiological studies have demonstrated associations between endometriosis and certain histotypes of ovarian cancer, including clear cell, low-grade serous and endometrioid carcinomas. We aimed to determine whether the observed associations might be due ... Full text Link to item Cite

Prognostic significance of differential expression of angiogenic genes in women with high-grade serous ovarian carcinoma.

Journal Article Gynecol Oncol · October 2015 OBJECTIVES: To identify angiogenic biomarkers associated with tumor angiogenesis and clinical outcome in high-grade serous ovarian cancer (HGSC). METHODS: 51 HGSC samples were analyzed using Affymetrix HG-U133A microarray. Microvessel density (MVD) counts ... Full text Link to item Cite

Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk.

Journal Article Cancer Epidemiol Biomarkers Prev · October 2015 BACKGROUND: Genome-wide association studies (GWAS) have so far reported 12 loci associated with serous epithelial ovarian cancer (EOC) risk. We hypothesized that some of these loci function through nearby transcription factor (TF) genes and that putative t ... Full text Link to item Cite

Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer.

Journal Article Nat Commun · September 22, 2015 Genome-wide association studies have reported 11 regions conferring risk of high-grade serous epithelial ovarian cancer (HGSOC). Expression quantitative trait locus (eQTL) analyses can identify candidate susceptibility genes at risk loci. Here we evaluate ... Full text Link to item Cite

Abstract POSTER-THER-1420: Ascites drives ovarian cancer stem-like cell growth: therapeutic opportunities

Conference Clinical Cancer Research · August 15, 2015 AbstractBackground: A significant literature suggests that cancer stem-like cells drive the aggressive behavior of ovarian cancer. Cancer stem-like cells are distinct from bulk tumor cells in possessing self ... Full text Cite

Abstract POSTER-BIOL-1319: Temporal shifts in the epigenetic regulation of tight junctions from primary to recurrent ovarian cancer

Conference Clinical Cancer Research · August 15, 2015 AbstractPurpose: Despite a complete clinical response following treatment with surgery and first-line chemotherapy, about 70-90% of patients with advanced stage ovarian cancer (OC) will inevitably experience ... Full text Cite

Genome-wide significant risk associations for mucinous ovarian carcinoma.

Journal Article Nat Genet · August 2015 Genome-wide association studies have identified several risk associations for ovarian carcinomas but not for mucinous ovarian carcinomas (MOCs). Our analysis of 1,644 MOC cases and 21,693 controls with imputation identified 3 new risk associations: rs75259 ... Full text Link to item Cite

Abstract 2236: Emergence of epigenetic regulation of tight junction genes in recurrent serous epithelial ovarian cancer

Conference Cancer Research · August 1, 2015 AbstractPurpose: Despite a complete clinical response following treatment with surgery and first-line chemotherapy, about 70-90% of advanced ovarian cancer (OC) patients experience cancer recurrence. Our obj ... Full text Cite

Abstract 4635: Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility

Conference Cancer Research · August 1, 2015 AbstractBackground: Recent bioinformatic analyses and high-throughput sequencing efforts have revealed that RNA editing is a widespread post-transcriptional modification that affects non-coding repetitive el ... Full text Cite

Abstract 4633: Evidence that long non-coding RNA variants associate with epithelial ovarian cancer risk

Conference Cancer Research · August 1, 2015 AbstractBackground: Genome wide association studies (GWAS) have identified 20 loci associated with epithelial ovarian cancer (EOC) risk. Additional EOC risk loci await identification, and biological approach ... Full text Cite

Abstract 4634: Variants within super-enhancer regulatory elements associate with epithelial ovarian cancer risk

Conference Cancer Research · August 1, 2015 AbstractBackground: Cell-type-specific super enhancers, or large clusters of mediator-rich enhancers, are highly transcribed regions of the genome with key functions in the maintenance of cell identity and c ... Full text Cite

Abstract 4636: Investigation of exome variants associated with overall survival in ovarian cancer

Conference Cancer Research · August 1, 2015 AbstractMany germline genetic variants have been found to be associated with susceptibility to epithelial ovarian cancer (EOC), but currently few associations have been identified for EOC outcomes such as ov ... Full text Cite

Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci.

Journal Article Hum Mol Genet · July 1, 2015 Understanding the regulatory landscape of the human genome is a central question in complex trait genetics. Most single-nucleotide polymorphisms (SNPs) associated with cancer risk lie in non-protein-coding regions, implicating regulatory DNA elements as fu ... Full text Link to item Cite

LIFETIME RISK OF OVARIAN CANCER BASED ON ENDOMETRIOSIS AND OTHER RISK FACTORS: IGCS-0014 06. Ovarian Cancer.

Journal Article Int J Gynecol Cancer · May 2015 Full text Link to item Cite

Population distribution of lifetime risk of ovarian cancer in the United States.

Journal Article Cancer Epidemiol Biomarkers Prev · April 2015 BACKGROUND: In U.S. women, lifetime risk of ovarian cancer is 1.37%, but some women are at a substantially lower or higher risk than this average. METHODS: We have characterized the distribution of lifetime risk in the general population. Published data on ... Full text Link to item Cite

Prophylactic oophorectomy for hereditary small cell carcinoma of the ovary, hypercalcemic type.

Journal Article Gynecol Oncol Rep · April 2015 •Prophylactic oophorectomy can prevent small cell carcinoma of the ovary, hypercalcemic type in carriers of germline SMARCA4 mutations.•Unaffected SMARCA4 mutation carriers who desire children may be best served by oocyte cryopreservation prior to prophyla ... Full text Link to item Cite

Evaluation of ERRα expression and association with survival in advanced ovarian cancer

Conference Gynecologic Oncology · April 2015 Full text Cite

Findings at laparoscopy, not debulking status, are associated with survival in advanced stage ovarian cancer after neoadjuvant chemotherapy

Conference Gynecologic Oncology · April 2015 Full text Cite

Relationship between body mass index (BMI) and gene expression profiles of high grade serous ovarian cancers in The Cancer Genome Atlas (TCGA) project

Conference Gynecologic Oncology · April 2015 Full text Cite

Sentinel lymph node mapping in women with high risk histology endometrial cancer

Conference Gynecologic Oncology · April 2015 Full text Cite

New cases of small cell carcinoma of the ovary, hypercalemic type caused by germline SMARCA4 mutations: An under-diagnosed entity?

Conference Gynecologic Oncology · April 2015 Full text Cite

KRAS variant rs61764370 is not associated with ovarian cancer risk or survival in the Ovarian Cancer Association Consortium (OCAC) or Consortium of Modifiers of BRCA1 and BRCA2 (CIMBA)

Conference Gynecologic Oncology · April 2015 Full text Cite

Evaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study.

Journal Article Gynecol Oncol · March 2015 OBJECTIVE: Ovarian cancer is a hormone-related disease with a strong genetic basis. However, none of its high-penetrance susceptibility genes and GWAS-identified variants to date are known to be involved in hormonal pathways. Given the hypothesized etiolog ... Full text Link to item Cite

Syngeneic Murine Ovarian Cancer Model Reveals That Ascites Enriches for Ovarian Cancer Stem-Like Cells Expressing Membrane GRP78.

Journal Article Mol Cancer Ther · March 2015 Patients with ovarian cancer are generally diagnosed at FIGO (International Federation of Gynecology and Obstetrics) stage III/IV, when ascites is common. The volume of ascites correlates positively with the extent of metastasis and negatively with prognos ... Full text Link to item Cite

Vaginal cuff thermal injury by mode of colpotomy at total laparoscopic hysterectomy: a randomized clinical trial.

Conference J Minim Invasive Gynecol · February 2015 STUDY OBJECTIVE: To evaluate if the use of Valleylab mode ("V mode") (Covidien, Mansfield, MA) electrothermal energy for colpotomy during total laparoscopic hysterectomy (LH) results in a smaller margin of thermal injury to the upper vagina compared with t ... Full text Link to item Cite

MicroRNAs in endometrial cancers from black and white patients.

Journal Article Am J Obstet Gynecol · February 2015 OBJECTIVE: Previous studies have identified differences in gene mutations among endometrial cancers from whites and blacks suggesting that differences in tumor biology may explain racial disparities in patient outcome. Micro RNAs (miRNAs) have emerged as r ... Full text Link to item Cite

Identification of six new susceptibility loci for invasive epithelial ovarian cancer.

Journal Article Nat Genet · February 2015 Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and BRCA2 mutation carriers who are at high risk of EOC. After imputation to 1 ... Full text Link to item Cite

Role of surgery in cancer prevention

Chapter · January 7, 2015 Cite

Role of surgery in cancer prevention

Chapter · January 7, 2015 Cite

Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk.

Journal Article PLoS One · 2015 BACKGROUND: Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which in turn may promote the formation of reactive oxygen species, promoting DNA damage and aberrant ex ... Full text Link to item Cite

Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC).

Journal Article J Genet Genome Res · 2015 Disruption in circadian gene expression, whether due to genetic variation or environmental factors (e.g., light at night, shiftwork), is associated with increased incidence of breast, prostate, gastrointestinal and hematologic cancers and gliomas. Circadia ... Full text Link to item Cite

Foreword

Journal Article · 2015 Cite

Patient preferences in advanced or recurrent ovarian cancer.

Journal Article Cancer · December 1, 2014 BACKGROUND: The objective of this study was to elucidate relative preferences of women with ovarian cancer for symptoms, treatment-related side effects, and progression-free survival (PFS) relevant to choosing a treatment regimen. METHODS: Women with advan ... Full text Link to item Cite

Biology and genetics

Chapter · November 11, 2014 Cite

LIFETIME RISK OF OVARIAN CANCER BASED ON ENDOMETRIOSIS AND OTHER RISK FACTORS

Journal Article INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER · November 1, 2014 Link to item Cite

PROPHYLACTIC OOPHORECTOMY FOR HEREDITARY SMALL-CELL CARCINOMA OF THE OVARY, HYPERCALCEMIC TYPE

Journal Article INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER · November 1, 2014 Link to item Cite

ENDOMETRIOSIS AND OVARIAN CANCER: AN INTERNATIONAL POOLED ANALYSIS

Journal Article INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER · November 1, 2014 Link to item Cite

IDENTIFICATION OF SIX NOVEL, COMMON VARIANT GENETIC SUSCEPTIBILITY LOCI FOR INVASIVE EPITHELIAL OVARIAN CANCER

Journal Article INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER · November 1, 2014 Link to item Cite

A modified bipedicle VRAM flap for simultaneous reconstruction of a perineal and posterior vaginal defect

Journal Article Gynakologe · October 14, 2014 The management of locally advanced pelvic tumors regularly requires radical surgical resection. The resection results in significant intrinsic and extrinsic pelvic defects. The advent of composite flaps has revolutionized vaginal and perineal reconstructio ... Full text Cite

Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk.

Journal Article Mol Nutr Food Res · October 2014 SCOPE: We reevaluated previously reported associations between variants in pathways of one-carbon (1-C) (folate) transfer genes and ovarian carcinoma (OC) risk, and in related pathways of purine and pyrimidine metabolism, and assessed interactions with fol ... Full text Link to item Cite

Abstract 4570: Role of ERRalpha in ovarian cancer

Conference Cancer Research · October 1, 2014 AbstractObjective. The estrogen receptor-related receptor-alpha (ERRα, encoded by ESRRA) has emerged as a key transcriptional regulator of mitochondrial function and has been implicated as a prognostic marke ... Full text Cite

Abstract 3283: GWAS identifies risk variants for mucinous ovarian carcinoma

Conference Cancer Research · October 1, 2014 AbstractBackground Genome-wide association studies (GWAS) previously identified 8 new risk loci for all subtypes of epithelial ovarian carcinoma (EOC) and one specific to invasive serous EOC. One locus, at 2 ... Full text Cite

Abstract 946: Exome genotyping array identifies rare and low-frequency variants that may be associated with ovarian cancer risk

Conference Cancer Research · October 1, 2014 AbstractBackground: Common genetic variants identified by genome-wide association studies and follow-up genotyping initiatives only explain a small proportion of the heritability of epithelial ovarian cancer ... Full text Cite

Abstract LB-89: Germ-line and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type

Conference Cancer Research · October 1, 2014 AbstractSmall-cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is an aggressive tumor and the most common type of undifferentiated ovarian malignancy presenting at less than 40 years of age. Its caus ... Full text Cite

Epigenetic determinants of ovarian clear cell carcinoma biology.

Journal Article Int J Cancer · August 1, 2014 Targeted approaches have revealed frequent epigenetic alterations in ovarian cancer, but the scope and relation of these changes to histologic subtype of disease is unclear. Genome-wide methylation and expression data for 14 clear cell carcinoma (CCC), 32 ... Full text Link to item Cite

Variation in NF-κB signaling pathways and survival in invasive epithelial ovarian cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · July 2014 Survival in epithelial ovarian cancer (EOC) is influenced by the host immune response, yet the key genetic determinants of inflammation and immunity that affect prognosis are not known. The nuclear factor-κB (NF-κB) transcription factor family plays an imp ... Full text Link to item Cite

ABCA transporter gene expression and poor outcome in epithelial ovarian cancer.

Journal Article J Natl Cancer Inst · July 2014 BACKGROUND: ATP-binding cassette (ABC) transporters play various roles in cancer biology and drug resistance, but their association with outcomes in serous epithelial ovarian cancer (EOC) is unknown. METHODS: The relationship between clinical outcomes and ... Full text Link to item Cite

Relative influence of factors determining a woman’s preference for treatment options in ovarian cancer.

Conference Journal of Clinical Oncology · May 20, 2014 Full text Cite

Relationship between minimally invasive hysterectomy, pelvic cytology, and lymph vascular space invasion: a single institution study of 458 patients.

Journal Article Gynecol Oncol · May 2014 OBJECTIVE: The aim of this study is to determine whether a minimally invasive approach to hysterectomy is associated with an increased rate of lymph vascular space invasion (LVSI) and/or malignant pelvic peritoneal cytology in endometrial cancer. METHODS: ... Full text Link to item Cite

Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type.

Journal Article Nat Genet · May 2014 Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is the most common undifferentiated ovarian malignancy in women under 40 years of age. We sequenced the exomes of six individuals from three families with SCCOHT. After discovering segregating ... Full text Link to item Cite

Relative Influence of Factors Determining a Woman’s Preference for Treatment Options in Ovarian Cancer: A Discrete Choice Experiment

Conference Value in Health · May 2014 Full text Cite

Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA.

Journal Article Hum Genet · May 2014 Epithelial ovarian cancer (EOC) is a heterogeneous cancer with both genetic and environmental risk factors. Variants influencing the risk of developing the less-common EOC subtypes have not been fully investigated. We performed a genome-wide association st ... Full text Link to item Cite

Large-scale evaluation of common variation in regulatory T cell-related genes and ovarian cancer outcome.

Journal Article Cancer Immunol Res · April 2014 The presence of regulatory T cells (Treg) in solid tumors is known to play a role in patient survival in ovarian cancer and other malignancies. We assessed inherited genetic variations via 749 tag single-nucleotide polymorphisms (SNP) in 25 Treg-associated ... Full text Link to item Cite

Risk of ovarian cancer and the NF-κB pathway: genetic association with IL1A and TNFSF10.

Journal Article Cancer Res · February 1, 2014 A missense single-nucleotide polymorphism (SNP) in the immune modulatory gene IL1A has been associated with ovarian cancer risk (rs17561). Although the exact mechanism through which this SNP alters risk of ovarian cancer is not clearly understood, rs17561 ... Full text Link to item Cite

Aspirin, nonaspirin nonsteroidal anti-inflammatory drug, and acetaminophen use and risk of invasive epithelial ovarian cancer: a pooled analysis in the Ovarian Cancer Association Consortium.

Journal Article J Natl Cancer Inst · February 2014 BACKGROUND: Regular aspirin use is associated with reduced risk of several malignancies. Epidemiologic studies analyzing aspirin, nonaspirin nonsteroidal anti-inflammatory drug (NSAID), and acetaminophen use and ovarian cancer risk have been inconclusive. ... Full text Link to item Cite

Differential Angiogenic Gene Expression in TP53 Wild-Type and Mutant Ovarian Cancer Cell Lines.

Journal Article Front Oncol · 2014 OBJECTIVES: Underlying mechanisms regulating angiogenesis in ovarian cancer have not been completely elucidated. Evidence suggests that the TP53 tumor suppressor pathway and tumor microenvironment play integral roles. We utilized microarray technology to s ... Full text Link to item Cite

A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk.

Journal Article Hum Mol Genet · December 15, 2013 Mean telomere length (TL) in blood cells is heritable and has been reported to be associated with risks of several diseases, including cancer. We conducted a meta-analysis of three GWAS for TL (total n=2240) and selected 1629 variants for replication via t ... Full text Link to item Cite

Evidence of a chemopreventive effect of progestin unrelated to ovulation on reproductive tract cancers in the egg-laying hen.

Journal Article Cancer Prev Res (Phila) · December 2013 Epidemiologic, laboratory, and animal evidence suggests that progestins and vitamin D may be potent ovarian cancer preventives. Our objectives were to evaluate progestins as reproductive tract cancer chemopreventives in the chicken, determine whether restr ... Full text Link to item Cite

Molecular signatures of epithelial ovarian cancer: analysis of associations with tumor characteristics and epidemiologic risk factors.

Journal Article Cancer Epidemiol Biomarkers Prev · October 2013 BACKGROUND: Six gene expression subtypes of invasive epithelial ovarian cancer were recently defined using microarrays by Tothill and colleagues. The Cancer Genome Atlas (TCGA) project subsequently replicated these subtypes and identified a signature predi ... Full text Link to item Cite

ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas.

Journal Article Gynecol Oncol · October 2013 OBJECTIVE: ABCB1 encodes the multi-drug efflux pump P-glycoprotein (P-gp) and has been implicated in multi-drug resistance. We comprehensively evaluated this gene and flanking regions for an association with clinical outcome in epithelial ovarian cancer (E ... Full text Link to item Cite

Genital powder use and risk of ovarian cancer: a pooled analysis of 8,525 cases and 9,859 controls.

Journal Article Cancer Prev Res (Phila) · August 2013 Genital powder use has been associated with risk of epithelial ovarian cancer in some, but not all, epidemiologic investigations, possibly reflecting the carcinogenic effects of talc particles found in most of these products. Whether risk increases with nu ... Full text Link to item Cite

Timing of end-of-life care discussion with performance on end-of-life quality indicators in ovarian cancer.

Journal Article Gynecol Oncol · July 2013 OBJECTIVES: (1) To describe the prevalence, timing and setting of documented end-of-life (EOL) discussions in patients with advanced ovarian cancer; and (2) to assess the impact of timing and setting of documented end-of-life discussions on EOL quality car ... Full text Link to item Cite

Transcript expression in endometrial cancers from Black and White patients.

Journal Article Gynecol Oncol · July 2013 OBJECTIVE: Previous studies suggest that differences in molecular features of endometrial cancers between racial groups may contribute to the poorer survival in Blacks. The objective of this investigation was to determine whether gene expression among endo ... Full text Link to item Cite

Preface

Journal Article Principles and Practice of Gynecologic Oncology: Sixth Edition · May 8, 2013 Cite

Principles and practice of gynecologic oncology: Sixth edition

Book · May 8, 2013 Today, multidisciplinary approaches to treatment are at the heart of cancer care. They offer improved clinical outcomes, new possibilities in patient quality of life, and enable the development of true innovation in individualized treatment. To accurately ... Cite

Molecular pathogenesis of gynecologic cancers

Chapter · May 8, 2013 Cite

Hereditary gynecologic cancers

Chapter · May 8, 2013 Cite

Integrated genomic characterization of endometrial carcinoma.

Journal Article Nature · May 2, 2013 We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array- and sequencing-based technologies. Uterine serous tumours and ∼25% of high-grade endometrioid tumours had extensive copy number alt ... Full text Link to item Cite

Analysis of over 10,000 Cases finds no association between previously reported candidate polymorphisms and ovarian cancer outcome.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2013 BACKGROUND: Ovarian cancer is a leading cause of cancer-related death among women. In an effort to understand contributors to disease outcome, we evaluated single-nucleotide polymorphisms (SNP) previously associated with ovarian cancer recurrence or surviv ... Full text Link to item Cite

Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2013 BACKGROUND: There are several well-established environmental risk factors for ovarian cancer, and recent genome-wide association studies have also identified six variants that influence disease risk. However, the interplay between such risk factors and sus ... Full text Link to item Cite

Abstract 4850: Variation in circadian rhythm genes influence epithelial ovarian cancer risk and invasiveness.

Conference Cancer Research · April 15, 2013 AbstractBackground: Circadian rhythms of biological processes are regulated by endogenous clock genes and clock-controlled genes. Aberrant expression of circadian clock genes may have important consequences ... Full text Cite

Abstract 330A: Differential expression of angiogenic genes in invasive high grade serous ovarian carcinomas.

Conference Cancer Research · April 15, 2013 AbstractOur objective is to establish quantifiable and reproducible biomarkers that can aid in prognosis, and predicting treatment outcome in invasive high-grade serous ovarian cancer (HGSC). The goal of thi ... Full text Cite

Abstract 1352: Epithelial-mesenchymal transition (EMT) gene variants influence epithelial ovarian cancer risk in women of European, African and Asian ancestry.

Conference Cancer Research · April 15, 2013 AbstractIntroductionThe epithelial-mesenchymal transition (EMT) pathway contributes to epithelial ovarian cancer (EOC) progression. Previously we identified associations of s ... Full text Cite

Abstract 4767: Preclinical mouse model of recurrent epithelial ovarian cancer.

Conference Cancer Research · April 15, 2013 AbstractPurpose: Most women diagnosed with advanced stage serous epithelial ovarian cancer exhibit a complete clinical response to surgical debulking and platinum-based chemotherapy. Remission can last month ... Full text Cite

Validation of ovarian cancer gene expression signatures for survival and subtype in formalin fixed paraffin embedded tissues.

Journal Article Gynecol Oncol · April 2013 INTRODUCTION: Gene expression signatures have been identified for epithelial ovarian cancer survival (TCGA) and intrinsic subtypes (Tothill et al.). One obstacle to clinical translation is that these signatures were developed using frozen tissue, whereas u ... Full text Link to item Cite

Vitamin D receptor (VDR) polymorphisms and risk of ovarian cancer in Caucasian and African American women.

Journal Article Gynecol Oncol · April 2013 OBJECTIVE: Polymorphisms in the vitamin D receptor (VDR) gene have been shown in some studies to be associated with the risk of epithelial ovarian cancer (EOC) in Caucasian women. There are no published reports among African Americans. METHODS: Case-contro ... Full text Link to item Cite

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.

Journal Article Nat Genet · April 2013 TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ∼480 SNPs at the TERT locus in breast (n = 103,991), ovarian (n = 39,774) and BRCA1 muta ... Full text Link to item Cite

GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.

Journal Article Nat Genet · April 2013 Genome-wide association studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC), with another two suggestive loci reaching near genome-wide significance. We pooled data from a GWAS conducted in North America with another ... Full text Link to item Cite

Tubal ligation and risk of ovarian cancer subtypes: a pooled analysis of case-control studies.

Journal Article Int J Epidemiol · April 2013 BACKGROUND: Tubal ligation is a protective factor for ovarian cancer, but it is unknown whether this protection extends to all invasive histological subtypes or borderline tumors. We undertook an international collaborative study to examine the association ... Full text Link to item Cite

BRCA1 immunohistochemistry in a molecularly characterized cohort of ovarian high-grade serous carcinomas.

Journal Article Am J Surg Pathol · January 2013 BRCA1 and BRCA2 dysfunction, frequently seen in high-grade serous ovarian carcinomas, often results from germline mutations, somatic mutations, and promoter methylation. Identification of tumors with BRCA defects has therapeutic and prognostic implications ... Full text Link to item Cite

Inherited variants in regulatory T cell genes and outcome of ovarian cancer.

Journal Article PLoS One · 2013 Although ovarian cancer is the most lethal of gynecologic malignancies, wide variation in outcome following conventional therapy continues to exist. The presence of tumor-infiltrating regulatory T cells (Tregs) has a role in outcome of this disease, and a ... Full text Link to item Cite

Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer.

Journal Article Nat Commun · 2013 HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with epithelial ovarian cancer risk ac ... Full text Link to item Cite

Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31.

Journal Article Nat Commun · 2013 Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized that variants in the 3' untranslated region at putative mi ... Full text Link to item Cite

Gene expression analysis of early stage endometrial cancers reveals unique transcripts associated with grade and histology but not depth of invasion.

Journal Article Front Oncol · 2013 Endometrial cancer is the most common gynecologic malignancy in the United States but it remains poorly understood at the molecular level. This investigation was conducted to specifically assess whether gene expression changes underlie the clinical and pat ... Full text Link to item Cite

Predictors of failure to perform pelvic peritoneal cytology in endometrial cancer staging surgery

Journal Article JOURNAL OF CLINICAL ONCOLOGY · December 1, 2012 Full text Link to item Cite

Predictors of failure to perform pelvic peritoneal cytology in endometrial cancer staging surgery.

Journal Article J Clin Oncol · December 2012 201 Background: The Federation of Gynecology and Obstetrics (FIGO) staging system and the National Comprehensive Cancer Network (NCCN) guidelines for endometrial cancer recommend performing pelvic peritoneal cytology to look for the presence of cancer cell ... Full text Link to item Cite

A phase I trial of dasatinib, an SRC-family kinase inhibitor, in combination with paclitaxel and carboplatin in patients with advanced or recurrent ovarian cancer.

Journal Article Clin Cancer Res · October 1, 2012 PURPOSE: We conducted a phase I study of dasatinib, an oral SRC-family tyrosine kinase inhibitor, in combination with paclitaxel and carboplatin in the treatment of advanced and recurrent epithelial ovarian cancer. EXPERIMENTAL DESIGN: The primary objectiv ... Full text Link to item Cite

Genetic testing in ovarian cancer: getting better, and maybe not just for disease susceptibility anymore.

Journal Article Obstet Gynecol · August 2012 Full text Link to item Cite

A multicenter, randomized, phase 2 clinical trial to evaluate the efficacy and safety of combination docetaxel and carboplatin and sequential therapy with docetaxel then carboplatin in patients with recurrent platinum-sensitive ovarian cancer.

Journal Article Cancer · July 1, 2012 BACKGROUND: The aim of this randomized clinical trial was to evaluate the efficacy and safety of combination (cDC) and sequential (sDC) weekly docetaxel and carboplatin in women with recurrent platinum-sensitive epithelial ovarian cancer (EOC). METHODS: Pa ... Full text Link to item Cite

Endometriosis and ovarian cancer - Authors' reply

Journal Article The Lancet Oncology · May 1, 2012 Full text Cite

Abstract LB-87: Methylated-mediated repression of ZNF154 in ovarian cancer is associated with poor overall survival

Journal Article Cancer Research · April 15, 2012 AbstractObjectives: Epigenetic gene regulation plays an important role in the development of cancer. We previously found that Zinc Finger Protein 154 (ZNF154), a Krüppel family zinc finger protein, is ubiqui ... Full text Cite

Abstract 5363: Aggregation rather than monoclonal expansion explains ovarian cancer spheroid formation

Journal Article Cancer Research · April 15, 2012 AbstractPurpose: It is thought that a subpopulation of ovarian cancer cells possess stem cell like properties and are responsible for both the emergence of cancer and for subsequent chemoresistance and recur ... Full text Cite

Abstract 2603: Subtype-specific ovarian cancer risk associated with SNPs in IL1A

Journal Article Cancer Research · April 15, 2012 AbstractAs pathways of the immune system play an important role in multiple malignancies, we assessed the association between single-nucleotide polymorphisms (SNPs) in inflammation-related genes and risk of ... Full text Cite

The influence of radiation modality and lymph node dissection on survival in early-stage endometrial cancer.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2012 BACKGROUND: The appropriate uses of lymph node dissection (LND) and adjuvant radiation therapy (RT) for Stage I endometrial cancer are controversial. We explored the impact of specific RT modalities (whole pelvic RT [WPRT], vaginal brachytherapy [VB]) and ... Full text Link to item Cite

Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies.

Journal Article Lancet Oncol · April 2012 BACKGROUND: Endometriosis is a risk factor for epithelial ovarian cancer; however, whether this risk extends to all invasive histological subtypes or borderline tumours is not clear. We undertook an international collaborative study to assess the associati ... Full text Link to item Cite

Role of common genetic variants in ovarian cancer susceptibility and outcome: progress to date from the Ovarian Cancer Association Consortium (OCAC).

Journal Article J Intern Med · April 2012 In this article, we review the current knowledge of the inherited genetics of epithelial ovarian cancer (EOC) susceptibility and clinical outcome. We focus on recent developments in identifying low-penetrance susceptibility genes and the role of the Ovaria ... Full text Link to item Cite

Common variation in Nemo-like kinase is associated with risk of ovarian cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2012 BACKGROUND: Overexpression of mitotic kinases has been associated with prognosis, histologic grade, and clinical stage in ovarian cancer, but the relationship between inherited variation in these genes and ovarian cancer risk has not been well defined. MET ... Full text Link to item Cite

Ovarian cancer risk associated with inherited inflammation-related variants.

Journal Article Cancer Res · March 1, 2012 The importance of inflammation pathways to the development of many human cancers prompted us to examine the associations between single-nucleotide polymorphisms (SNP) in inflammation-related genes and risk of ovarian cancer. In a multisite case-control stu ... Full text Link to item Cite

Minimally invasive surgery for endometrial cancer: the horse is already out of the barn.

Journal Article J Clin Oncol · March 1, 2012 Full text Link to item Cite

Nonsteroidal antiinflammatory drugs and progestins synergistically enhance cell death in ovarian epithelial cells.

Journal Article Am J Obstet Gynecol · March 2012 OBJECTIVE: There is growing evidence that progestins and nonsteroidal antiinflammatory drugs (NSAIDs) may prevent ovarian cancer. Because both induce apoptosis, we investigated the potential for synergistic impact of combined drug treatment on cell death. ... Full text Link to item Cite

DNA Methylation Profiles Distinguish Serous, Mucinous and Clear Cell but not Endometrioid Epithelial Ovarian Cancers

Journal Article Gynecologic Oncology · March 2012 Full text Cite

Frequency of the cancer genome atlas expression subtypes differs between early and advanced stage high grade serous ovarian cancers

Journal Article Gynecologic Oncology · March 2012 Full text Cite

Clinical translation of the cancer genome atlas signature for ovarian cancer survival

Journal Article Gynecologic Oncology · March 2012 Full text Cite

Loss of p16 in advanced stage epithelial ovarian cancer is associated with chemoresistant disease, suboptimal debulking and poor progression-free survival: A Gynecologic Oncology Group study.

Journal Article Gynecologic Oncology · March 2012 Full text Cite

Retraction. An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer.

Other J Clin Oncol · February 20, 2012 Full text Link to item Cite

Cost-effectiveness of combination versus sequential docetaxel and carboplatin for the treatment of platinum-sensitive, recurrent ovarian cancer.

Journal Article Cancer · January 15, 2012 BACKGROUND: In a randomized controlled trial (RCT) of patients with recurrent, platinum-sensitive ovarian cancer, the combination weekly docetaxel and carboplatin was associated a with progression-free survival (PFS) of 13.7 months compared with 8.4 months ... Full text Link to item Cite

Loss of ARID1A-associated protein expression is a frequent event in clear cell and endometrioid ovarian cancers.

Journal Article Int J Gynecol Cancer · January 2012 BACKGROUND: Inactivating somatic mutations in the ARID1A gene are described in a significant fraction of clear cell and endometrioid ovarian cancers leading to loss of the corresponding protein (BAF250a). Expression of BAF250a was examined in clear cell an ... Full text Link to item Cite

Analysis of PSPHL as a Candidate Gene Influencing the Racial Disparity in Endometrial Cancer.

Journal Article Front Oncol · 2012 Endometrial cancer is the most commonly diagnosed gynecologic malignancy in the United States. A well recognized disparity by race in both incidence and survival outcome exists for this cancer. Specifically Caucasians are about two times more likely to dev ... Full text Link to item Cite

Regular Multivitamin Supplement Use, Single Nucleotide Polymorphisms in ATIC, SHMT2, and SLC46A1, and Risk of Ovarian Carcinoma.

Journal Article Front Genet · 2012 ATIC, SHMT2, and SLC46A1 have essential roles in one-carbon (1-C) transfer. The authors examined whether associations between ovarian carcinoma and 15 variants in these genes are modified by regular multivitamin use, a source of 1-C donors, among Caucasian ... Full text Link to item Cite

Ovarian cancer progenitor/stem cells: Therapeutic potential

Journal Article · December 1, 2011 A number of studies provide evidence for the existence of ovarian cancer stem cells, defined by functional attributes, foremost the ability to reconstruct the heterogeneity of the original tumor in immunocompromised mice through asymmetric cell division. A ... Full text Cite

Quantitative detection of RASSF1A DNA promoter methylation in tumors and serum of patients with serous epithelial ovarian cancer.

Journal Article Gynecol Oncol · December 2011 OBJECTIVE: Detection of cell free tumor-specific DNA methylation has been proposed as a potentially useful noninvasive mechanism to detect malignancies, including ovarian cancer, and to monitor response to treatment. However, there are few easily implement ... Full text Link to item Cite

Response to Weidhaas and Slack re: Comments on "The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implication for clinical testing".

Journal Article Clin Cancer Res · October 15, 2011 Full text Link to item Cite

BAD phosphorylation determines ovarian cancer chemosensitivity and patient survival.

Journal Article Clin Cancer Res · October 1, 2011 PURPOSE: Despite initial sensitivity to chemotherapy, ovarian cancers (OVCA) often develop drug resistance, which limits patient survival. Using specimens and/or genomic data from 289 patients and a panel of cancer cell lines, we explored genome-wide expre ... Full text Link to item Cite

OP 54 A genomic-based signature of response to chemotherapy in ovarian cancer fails to predict clinical outcome in two independent cohorts.

Conference European Journal of Cancer · October 2011 Full text Cite

What Are The Causes Of Death For Women With Early-stage Endometrial Cancer?

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Rethinking ovarian cancer: recommendations for improving outcomes.

Journal Article Nat Rev Cancer · September 23, 2011 There have been major advances in our understanding of the cellular and molecular biology of the human malignancies that are collectively referred to as ovarian cancer. At a recent Helene Harris Memorial Trust meeting, an international group of researchers ... Full text Link to item Cite

Large prospective study of ovarian cancer screening in high-risk women: CA125 cut-point defined by menopausal status.

Journal Article Cancer Prev Res (Phila) · September 2011 Previous screening trials for early detection of ovarian cancer in postmenopausal women have used the standard CA125 cut-point of 35 U/mL, the 98th percentile in this population yielding a 2% false positive rate, whereas the same cut-point in trials of pre ... Full text Link to item Cite

Cost comparison of strategies for the management of venous thromboembolic event risk following laparotomy for ovarian cancer.

Journal Article Gynecol Oncol · September 2011 OBJECTIVE: To evaluate the costs and effectiveness of thromboprophylaxis strategies following laparotomy for ovarian cancer. METHODS: We constructed a decision model to evaluate six strategies for management of postoperative venous thromboembolism (VTE) ri ... Full text Link to item Cite

MicroRNA processing and binding site polymorphisms are not replicated in the Ovarian Cancer Association Consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · August 2011 BACKGROUND: Single nucleotide polymorphisms (SNP) in microRNA-related genes have been associated with epithelial ovarian cancer (EOC) risk in two reports, yet associated alleles may be inconsistent across studies. METHODS: We conducted a pooled analysis of ... Full text Link to item Cite

Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines.

Journal Article Cancer Res · August 1, 2011 Cancer cells are defined by their ability to invade through the basement membrane, a critical step during metastasis. While increased secretion of proteases, which facilitates degradation of the basement membrane, and alterations in the cytoskeletal archit ... Full text Link to item Cite

Adverse events associated with laparoscopy vs laparotomy in the treatment of endometrial cancer.

Journal Article Am J Obstet Gynecol · August 2011 OBJECTIVE: The objective of the study was to compare adverse event rates between laparoscopic vs open surgery for endometrial cancer. STUDY DESIGN: This was a retrospective cohort study comparing 107 women who underwent laparoscopy with 269 age- and body m ... Full text Link to item Cite

Association between KRAS rs61764370 and triple-negative breast cancer--a false positive?

Journal Article Lancet Oncol · August 2011 Full text Link to item Cite

Integrated genomic analyses of ovarian carcinoma.

Journal Article Nature · June 29, 2011 A catalogue of molecular aberrations that cause ovarian cancer is critical for developing and deploying therapies that will improve patients' lives. The Cancer Genome Atlas project has analysed messenger RNA expression, microRNA expression, promoter methyl ... Full text Link to item Cite

Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk.

Journal Article Hum Mol Genet · June 1, 2011 The insulin-like growth factor (IGF) signaling axis plays an important role in cancer biology. We hypothesized that genetic variation in this pathway may influence risk of ovarian cancer. A three-center study of non-Hispanic whites including 1880 control w ... Full text Link to item Cite

The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing.

Journal Article Clin Cancer Res · June 1, 2011 PURPOSE: An assay for the single-nucleotide polymorphism (SNP), rs61764370, has recently been commercially marketed as a clinical test to aid ovarian cancer risk evaluation in women with family histories of the disease. rs67164370 is in a 3'-UTR miRNA bind ... Full text Link to item Cite

Proteomic analysis of stage I endometrial cancer tissue: identification of proteins associated with oxidative processes and inflammation.

Journal Article Gynecol Oncol · June 1, 2011 OBJECTIVE: The present study aimed to identify differentially expressed proteins employing a high resolution mass spectrometry (MS)-based proteomic analysis of endometrial cancer cells harvested using laser microdissection. METHODS: A differential MS-based ... Full text Link to item Cite

Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer.

Journal Article Int J Cancer · May 1, 2011 Common germline genetic variation in the population is associated with susceptibility to epithelial ovarian cancer. Microcell-mediated chromosome transfer and expression microarray analysis identified nine genes associated with functional suppression of tu ... Full text Link to item Cite

Xenobiotic-Metabolizing gene polymorphisms and ovarian cancer risk.

Journal Article Mol Carcinog · May 2011 Because selected xenobiotic-metabolizing enzymes process pro-carcinogens that could initiate ovarian carcinogenesis, we hypothesized that single nucleotide polymorphisms (SNPs) in the genes encoding xenobiotic-metabolizing enzymes are associated with risk ... Full text Link to item Cite

Prostate cancer susceptibility polymorphism rs2660753 is not associated with invasive ovarian cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2011 BACKGROUND: We previously reported an association between rs2660753, a prostate cancer susceptibility polymorphism, and invasive epithelial ovarian cancer (EOC; OR = 1.2, 95% CI=1.0-1.4, P(trend) = 0.01) that showed a stronger association with the serous h ... Full text Link to item Cite

Association of KRAS SNP rs61764370 with risk of invasive epithelial ovarian cancer: Implications for clinical testing

Journal Article Gynecologic Oncology · May 2011 Full text Cite

Abstract 3014: Quantitative accuracy of Illumina HumanMethylation27 Infinium BeadChip data assessed by pyrosequencing

Journal Article Cancer Research · April 15, 2011 AbstractPurpose. Aberrant DNA methylation can lead to changes in gene expression, and this alteration is highly relevant in the context of cancer. The ability to accurately assess DNA methylation status is t ... Full text Cite

Dasatinib (BMS-35482) has synergistic activity with paclitaxel and carboplatin in ovarian cancer cells.

Journal Article Gynecol Oncol · April 2011 PURPOSE: To explore the activity of dasatinib alone and in combination with paclitaxel and carboplatin in ovarian cancer cells and to determine if dasatinib activity can be predicted based on evaluation of the SRC pathway. EXPERIMENTAL DESIGN: Microarray a ... Full text Link to item Cite

Prevention and early detection of cancer.

Journal Article Gynecol Oncol · April 2011 Full text Link to item Cite

Reduction of ovarian and oviductal cancers in calorie-restricted laying chickens.

Journal Article Cancer Prev Res (Phila) · April 2011 Epithelial ovarian cancer (OVAC) remains a highly lethal malignancy. It is a leading cause of cancer deaths among women in the United States causing more deaths than all other gynecologic malignancies combined. The pathogenesis of OVAC is not completely un ... Full text Link to item Cite

Loss of ARID1A is a frequent event in clear cell and endometrioid ovarian cancers

Journal Article Gynecologic Oncology · March 2011 Full text Cite

DNA methylation markers associated with serous ovarian cancer subtypes

Journal Article Gynecologic Oncology · March 2011 Full text Cite

Common single-nucleotide polymorphisms in the BNC2, HOXD1 and MERIT40 regions contribute significantly to racial differences in ovarian cancer incidence

Journal Article Gynecologic Oncology · March 2011 Full text Cite

Concordant gene expression profiles in matched primary and recurrent serous ovarian cancers predict platinum response

Journal Article Gynecologic Oncology · March 2011 Full text Cite

Genes functionally regulated by methylation in ovarian cancer are involved in cell proliferation, development and morphogenesis

Journal Article Gynecologic Oncology · March 2011 Full text Cite

Cost comparison of strategies for the management of venous thromboembolic event risk following laparotomy for ovarian cancer

Journal Article Gynecologic Oncology · March 2011 Full text Cite

Genomewide methylation analyses reveal a prominent role of HINF1 network genes, via hypomethylation, in ovarian clear cell carcinoma

Journal Article Gynecologic Oncology · March 2011 Full text Cite

BAD apoptosis pathway expression and survival from cancer

Journal Article Gynecologic Oncology · March 2011 Full text Cite

Development of an ovarian cancer screening decision model that incorporates disease heterogeneity: implications for potential mortality reduction.

Journal Article Cancer · February 1, 2011 BACKGROUND: Pathologic and genetic data suggest that epithelial ovarian cancer may consist of indolent and aggressive phenotypes. The objective of the current study was to estimate the impact of a 2-phenotype paradigm of epithelial ovarian cancer on the mo ... Full text Link to item Cite

Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer.

Journal Article Genome Res · January 2011 Epithelial ovarian cancer is the leading cause of death among gynecologic malignancies. Diagnosis usually occurs after metastatic spread, largely reflecting vague symptoms of early disease combined with lack of an effective screening strategy. Epigenetic m ... Full text Link to item Cite

Polymorphisms in stromal genes and susceptibility to serous epithelial ovarian cancer: a report from the Ovarian Cancer Association Consortium.

Journal Article PLoS One · 2011 Alterations in stromal tissue components can inhibit or promote epithelial tumorigenesis. Decorin (DCN) and lumican (LUM) show reduced stromal expression in serous epithelial ovarian cancer (sEOC). We hypothesized that common variants in these genes associ ... Full text Link to item Cite

Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort.

Journal Article Fertil Steril · January 2011 OBJECTIVE: To investigate the association between self-reported endometriosis and the putative functional promoter +331C/T single nucleotide polymorphism and the PROGINS allele. DESIGN: Control subjects from ovarian cancer case-control studies participatin ... Full text Link to item Cite

Estrogen receptor beta rs1271572 polymorphism and invasive ovarian carcinoma risk: pooled analysis within the Ovarian Cancer Association Consortium.

Journal Article PLoS One · 2011 The association of ovarian carcinoma risk with the polymorphism rs1271572 in the estrogen receptor beta (ESR2) gene was examined in 4946 women with primary invasive ovarian carcinoma and 6582 controls in a pooled analysis of ten case-control studies within ... Full text Link to item Cite

Genome-scale screen for DNA methylation-based detection markers for ovarian cancer.

Journal Article PLoS One · 2011 BACKGROUND: The identification of sensitive biomarkers for the detection of ovarian cancer is of high clinical relevance for early detection and/or monitoring of disease recurrence. We developed a systematic multi-step biomarker discovery and verification ... Full text Link to item Cite

Retraction: Genomic signatures to guide the use of chemotherapeutics.

Other Nat Med · January 2011 Full text Link to item Cite

Projecting the need for gynecologic oncologists for the next 40 years.

Journal Article Obstet Gynecol · December 2010 OBJECTIVE: To estimate the ratio of gynecologic cancer cases to practicing gynecologic oncologists in the United States over the next 40 years. METHODS: Using population projections from the U.S. Census Bureau and incidence and mortality rates from Surveil ... Full text Link to item Cite

Secondary Malignancy after Radiation for Endometrial Cancer: Comparing No Radiation, External Beam, and Brachytherapy

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.

Journal Article Nat Genet · October 2010 Ovarian cancer accounts for more deaths than all other gynecological cancers combined. To identify common low-penetrance ovarian cancer susceptibility genes, we conducted a genome-wide association study of 507,094 SNPs in 1,768 individuals with ovarian can ... Full text Link to item Cite

Common variants at 19p13 are associated with susceptibility to ovarian cancer.

Journal Article Nat Genet · October 2010 Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 indi ... Full text Link to item Cite

Prophylactic and risk-reducing bilateral salpingo-oophorectomy: recommendations based on risk of ovarian cancer.

Journal Article Obstet Gynecol · September 2010 Women who do not have a documented germline mutation or who do not have a strong family history suspicious for a germline mutation are considered to be at average risk of ovarian cancer. Women who have confirmed deleterious BRCA1 and BRCA2 germline mutatio ... Full text Link to item Cite

Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".

Journal Article PLoS Genet · July 8, 2010 We hypothesized that variants in genes expressed as a consequence of interactions between ovarian cancer cells and the host micro-environment could contribute to cancer susceptibility. We therefore used a two-stage approach to evaluate common single nucleo ... Full text Link to item Cite

Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · July 2010 BACKGROUND: We previously reported the risks of ovarian carcinoma for common polymorphisms in one-carbon transfer genes. We sought to replicate associations for DPYD rs1801265, DNMT3A rs13420827, MTHFD1 rs1950902, MTHFS rs17284990, and TYMS rs495139 with r ... Full text Link to item Cite

Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".

Journal Article PLoS genetics · July 1, 2010 We hypothesized that variants in genes expressed as a consequence of interactions between ovarian cancer cells and the host micro-environment could contribute to cancer susceptibility. We therefore used a two-stage approach to evaluate common single nucleo ... Cite

Microcell-mediated chromosome transfer identifies EPB41L3 as a functional suppressor of epithelial ovarian cancers.

Journal Article Neoplasia · July 2010 We used a functional complementation approach to identify tumor-suppressor genes and putative therapeutic targets for ovarian cancer. Microcell-mediated transfer of chromosome 18 in the ovarian cancer cell line TOV21G induced in vitro and in vivo neoplasti ... Full text Link to item Cite

Expression signatures of TP53 mutations in serous ovarian cancers.

Journal Article BMC Cancer · May 26, 2010 BACKGROUND: Mutations in the TP53 gene are extremely common and occur very early in the progression of serous ovarian cancers. Gene expression patterns that relate to mutational status may provide insight into the etiology and biology of the disease. METHO ... Full text Open Access Link to item Cite

Influence of radiation modality and nodal dissection on survival in high-risk early-stage endometrial cancer.

Journal Article Journal of Clinical Oncology · May 20, 2010 Full text Cite

Targeting slow-proliferating ovarian cancer cells.

Journal Article Int J Cancer · May 15, 2010 Advanced ovarian cancer has a high rate of recurrence and mortality despite relative chemosensitivity at the time of initial treatment. Conventional chemotherapeutic agents typically target rapidly dividing cells. Disease relapse may therefore result from ... Full text Link to item Cite

Association between DNA damage response and repair genes and risk of invasive serous ovarian cancer.

Journal Article PLoS One · April 8, 2010 BACKGROUND: We analyzed the association between 53 genes related to DNA repair and p53-mediated damage response and serous ovarian cancer risk using case-control data from the North Carolina Ovarian Cancer Study (NCOCS), a population-based, case-control st ... Full text Open Access Link to item Cite

Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer.

Journal Article Int J Cancer · March 15, 2010 We previously found that the gene encoding the Myelin and Lymphocyte protein, MAL, was among the most highly expressed genes in serous ovarian cancers from short-term survivors (<3 years) relative to those of long-term survivors (>7 years). In the present ... Full text Link to item Cite

Ovarian cancer tumor infiltrating T-regulatory (T(reg)) cells are associated with a metastatic phenotype.

Journal Article Gynecol Oncol · March 2010 OBJECTIVE: The objective of this study was to examine the clinicopathologic correlates of T-regulatory (T(reg)) cell infiltration in serous ovarian cancers and to define gene signatures associated with high T(reg)s. METHODS: Tumor infiltrating T(reg) and c ... Full text Link to item Cite

Gene expression profiling of invasive serous ovarian cancers from formalin-fixed, paraffin-embedded tissues using DASL

Journal Article GYNECOLOGIC ONCOLOGY · March 1, 2010 Link to item Cite

Adverse events associated with laparoscopy versus laparotomy in the treatment of stage I endometrial cancer

Journal Article GYNECOLOGIC ONCOLOGY · March 1, 2010 Link to item Cite

Projecting the need for gynecologic oncologists for the next 40 years: Not enough, too many or just right?

Journal Article GYNECOLOGIC ONCOLOGY · March 1, 2010 Link to item Cite

Genomic SRC signature and SRC protein expression in ovarian cancers may predict response to the SRC inhibitor dasatinib

Journal Article GYNECOLOGIC ONCOLOGY · March 1, 2010 Link to item Cite

Genomic analysis defines biological pathway differences between early- and advanced-stage ovarian cancers

Journal Article GYNECOLOGIC ONCOLOGY · March 1, 2010 Link to item Cite

Indolent and aggressive phenotypes of epithelial ovarian cancer: Implications for screening

Journal Article GYNECOLOGIC ONCOLOGY · March 1, 2010 Link to item Cite

A multicenter, randomized, phase II study evaluating the efficacy and safety of combination docetaxel and carboplatin and sequential therapy with docetaxel then carboplatin in patients with recurrent platinum-sensitive ovarian cancer

Journal Article GYNECOLOGIC ONCOLOGY · March 1, 2010 Link to item Cite

Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer.

Journal Article Twin Res Hum Genet · February 2010 The chromosome 8q24 region (specifically, 8q24.21.a) is known to harbor variants associated with risk of breast, colorectal, prostate, and bladder cancers. In 2008, variants rs10505477 and rs6983267 in this region were associated with increased risk of inv ... Full text Link to item Cite

Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · February 2010 Aberrant glycosylation is a well-described hallmark of cancer. In a previous ovarian cancer case control study that examined polymorphisms in 26 glycosylation-associated genes, we found strong statistical evidence (P = 0.00017) that women who inherited two ... Full text Link to item Cite

Risk of ovarian cancer and inherited variants in relapse-associated genes.

Journal Article PLoS One · January 27, 2010 BACKGROUND: We previously identified a panel of genes associated with outcome of ovarian cancer. The purpose of the current study was to assess whether variants in these genes correlated with ovarian cancer risk. METHODS AND FINDINGS: Women with and withou ... Full text Open Access Link to item Cite

High poly(adenosine diphosphate-ribose) polymerase expression and poor survival in advanced-stage serous ovarian cancer.

Journal Article Obstet Gynecol · January 2010 OBJECTIVE: To estimate the range of poly(adenosine diphosphate [ADP]-ribose) polymerase expression in serous ovarian cancers and to determine whether expression is associated with response to therapy and outcome. METHODS: Immunostaining for poly(ADP-ribose ... Full text Link to item Cite

ESR1/SYNE1 polymorphism and invasive epithelial ovarian cancer risk: an Ovarian Cancer Association Consortium study.

Journal Article Cancer Epidemiol Biomarkers Prev · January 2010 We genotyped 13 single nucleotide polymorphisms (SNPs) in the estrogen receptor alpha gene (ESR1) region in three population-based case-control studies of epithelial ovarian cancer conducted in the United States, comprising a total of 1,128 and 1,866 non-H ... Full text Link to item Cite

Association between the N-terminally truncated (DeltaN) p63alpha (DeltaNp63alpha) isoform and debulking status, VEGF expression and progression-free survival in previously untreated, advanced stage epithelial ovarian cancer: A Gynecologic Oncology Group study.

Journal Article Gynecol Oncol · December 2009 OBJECTIVES: The Gynecologic Oncology Group (GOG) examined the association between the relative expression of the DeltaNp63alpha isoform and clinicopathologic variables, p53 status, angiogenic markers, progression-free survival (PFS) and overall survival (O ... Full text Link to item Cite

Erratum: Validating genetic risk associations for ovarian cancer through the International Ovarian Cancer Association Consortium (British Journal of Cancer (2009) 100 (412-420) DOI: 10.1038/sj.bjc.6604820 www.bjcancer.com)

Journal Article British Journal of Cancer · November 1, 2009 Full text Cite

Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.

Journal Article Br J Cancer · October 20, 2009 BACKGROUND: Dysregulation of the cell cycle is a hallmark of many cancers including ovarian cancer, a leading cause of gynaecologic cancer mortality worldwide. METHODS: We examined single nucleotide polymorphisms (SNPs) (n=288) from 39 cell cycle regulatio ... Full text Link to item Cite

A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2.

Journal Article Nat Genet · September 2009 Epithelial ovarian cancer has a major heritable component, but the known susceptibility genes explain less than half the excess familial risk. We performed a genome-wide association study (GWAS) to identify common ovarian cancer susceptibility alleles. We ... Full text Link to item Cite

Ovarian cancer risk factors in African-American and white women.

Journal Article Am J Epidemiol · September 1, 2009 Ovarian cancer is the most lethal gynecologic malignancy in both African-American and white women. Although prevalences of many ovarian cancer risk factors differ markedly between African Americans and whites, there has been little research on how the rela ... Full text Link to item Cite

MLH1 expression sensitises ovarian cancer cells to cell death mediated by XIAP inhibition.

Journal Article Br J Cancer · July 21, 2009 BACKGROUND: The X-linked inhibitor of apoptosis protein (XIAP), an endogenous apoptosis suppressor, can determine the level of caspase accumulation and the resultant response to apoptosis-inducing agents such as cisplatin in epithelial ovarian cancer (EOC) ... Full text Link to item Cite

Evaluation of two management strategies for preoperative grade 1 endometrial cancer.

Journal Article Obstet Gynecol · July 2009 OBJECTIVE: To compare the practices, adjuvant treatment, and outcomes of patients with preoperatively assessed grade 1 endometrioid endometrial cancer between two academic gynecologic oncology centers that use different treatment strategies. METHODS: A ret ... Full text Link to item Cite

Microarray analysis of gene expression in gynecologic cancers--still only the beginning.

Journal Article Gynecol Oncol · July 2009 Full text Link to item Cite

Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study.

Journal Article Hum Mol Genet · June 15, 2009 Because both ovarian and breast cancer are hormone-related and are known to have some predisposition genes in common, we evaluated 11 of the most significant hits (six with confirmed associations with breast cancer) from the breast cancer genome-wide assoc ... Full text Link to item Cite

UCN-01 is effective in targeting ovarian cancer spheroids

Journal Article CANCER RESEARCH · May 1, 2009 Link to item Cite

CTCF binding at a novel intragenic binding site is associated with elevated IGF2 expression in serous epithelial ovarian cancer

Journal Article CANCER RESEARCH · May 1, 2009 Link to item Cite

Association between serous invasive ovarian cancer and variants in candidate DNA damage response genes

Journal Article CANCER RESEARCH · May 1, 2009 Link to item Cite

In vitro characterization of the antitumor effects of dasatinib (BMS-354825) in combination with paclitaxel and carboplatin in human ovarian cancer cell lines

Journal Article CANCER RESEARCH · May 1, 2009 Link to item Cite

Microarray analysis of early stage serous ovarian cancers shows profiles predictive of favorable outcome.

Journal Article Clin Cancer Res · April 1, 2009 Featured Publication PURPOSE: Although few women with advanced serous ovarian cancer are cured, detection of the disease at an early stage is associated with a much higher likelihood of survival. We previously used gene expression array analysis to distinguish subsets of advan ... Full text Link to item Cite

Role of genetic polymorphisms and ovarian cancer susceptibility.

Journal Article Mol Oncol · April 2009 The value of identifying women with an inherited predisposition to epithelial ovarian cancer has become readily apparent with the identification of the BRCA1, and BRCA2 genes. Women who inherit a deleterious mutation in either of these genes have a very hi ... Full text Link to item Cite

Single nucleotide polymorphisms in the TP53 region and susceptibility to invasive epithelial ovarian cancer.

Journal Article Cancer Res · March 15, 2009 Featured Publication The p53 protein is critical for multiple cellular functions including cell growth and DNA repair. We assessed whether polymorphisms in the region encoding TP53 were associated with risk of invasive ovarian cancer. The study population includes a total of 5 ... Full text Link to item Cite

Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31, CD105, p53 status, and angiogenic marker expression: A Gynecologic Oncology Group study.

Journal Article Gynecol Oncol · March 2009 OBJECTIVES: The aims of this study were to examine prognostic significance of microvessel density (MVD) in previously-untreated, advanced epithelial ovarian cancer (EOC) and explore associations between MVD and factors that affect angiogenesis. METHODS: MV ... Full text Link to item Cite

Yin yang 1 modulates taxane response in epithelial ovarian cancer.

Journal Article Mol Cancer Res · February 2009 Survival of ovarian cancer patients is largely dictated by their response to chemotherapy, which depends on underlying molecular features of the malignancy. We previously identified YIN YANG 1 (YY1) as a gene whose expression is positively correlated with ... Full text Link to item Cite

Ovarian adenocarcinomas in the laying hen and women share similar alterations in p53, ras, and HER-2/neu.

Journal Article Cancer Prev Res (Phila) · February 2009 We examined alterations in the p53 tumor suppressor gene and the ras and HER-2/neu oncogenes in chicken ovarian cancers to determine if these tumors have genetic alterations similar to those in human ovarian adenocarcinomas. Mutations in the p53 tumor supp ... Full text Link to item Cite

High poly (ADP-ribose) polymerase (PARP) expression is associated with poor survival in advanced-stage serous ovarian cancer

Journal Article GYNECOLOGIC ONCOLOGY · February 1, 2009 Link to item Cite

Genomic predictors of ovarian cancer response to salvage therapy

Journal Article GYNECOLOGIC ONCOLOGY · February 1, 2009 Link to item Cite

7-hydroxystaurosporine (UCN-01) is effective in targeting ovarian cancer spheroids

Journal Article GYNECOLOGIC ONCOLOGY · February 1, 2009 Link to item Cite

Gene signature specific for ovarian clear cell carcinoma is induced by the contents of endometriotic cysts

Journal Article GYNECOLOGIC ONCOLOGY · February 1, 2009 Link to item Cite

Ovarian cancer tumor-infiltrating regulatory T cells are associated with a metastatic phenotype

Journal Article GYNECOLOGIC ONCOLOGY · February 1, 2009 Link to item Cite

Loss of GPR54 correlates with stem cell activity in high-grade endometrial cancer

Journal Article GYNECOLOGIC ONCOLOGY · February 1, 2009 Link to item Cite

Intragenic methylation at a novel CTCF binding site is associated with elevated IGF2 expression in serous epithelial ovarian cancer

Journal Article GYNECOLOGIC ONCOLOGY · February 1, 2009 Link to item Cite

Validation of the MAL gene as a predictor of survival in advanced-stage high-grade serous ovarian cancer

Journal Article GYNECOLOGIC ONCOLOGY · February 1, 2009 Link to item Cite

Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium.

Journal Article Br J Cancer · January 27, 2009 The search for genetic variants associated with ovarian cancer risk has focused on pathways including sex steroid hormones, DNA repair, and cell cycle control. The Ovarian Cancer Association Consortium (OCAC) identified 10 single-nucleotide polymorphisms ( ... Full text Link to item Cite

Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium

Journal Article British Journal of Cancer · January 27, 2009 Full text Cite

Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells.

Journal Article Oncogene · January 15, 2009 Featured Publication The cancer stem cell hypothesis posits that malignant growth arises from a rare population of progenitor cells within a tumor that provide it with unlimited regenerative capacity. Such cells also possess increased resistance to chemotherapeutic agents. Res ... Full text Link to item Cite

Robotic-assisted laparoscopic gynecologic procedures in a fellowship training program.

Journal Article JSLS · 2009 BACKGROUND AND OBJECTIVE: The robotic surgical platform is an alternative technique to traditional laparoscopy and requires the development of new surgical skills for both the experienced surgeon and trainee. Our goal was to perform an early evaluation of ... Full text Link to item Cite

Relationship between tamoxifen use and high risk endometrial cancer histologic types.

Journal Article Gynecol Oncol · January 2009 OBJECTIVES: We wished to determine whether a pre-existing diagnosis of breast cancer or the use of tamoxifen among patients with pre-existing breast cancer influences the histologic type of subsequently diagnosed endometrial carcinoma, the interval between ... Full text Link to item Cite

Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.

Journal Article Cancer Epidemiol Biomarkers Prev · December 2008 Featured Publication Over 22,000 cases of ovarian cancer were diagnosed in 2007 in the United States, but only a fraction of them can be attributed to mutations in highly penetrant genes such as BRCA1. To determine whether low-penetrance genetic variants contribute to ovarian ... Full text Link to item Cite

Evaluation of biomarker panels for early stage ovarian cancer detection and monitoring for disease recurrence.

Journal Article Gynecol Oncol · September 2008 Featured Publication OBJECTIVE: To determine the utility of novel combinations of biomarkers, using both a one-step and two-step assay format, to distinguish serum of early ovarian cancer patients from that of healthy controls and to discern the utility of these biomarkers in ... Full text Link to item Cite

Corrigendum: Genomic signatures to guide the use of chemotherapeutics (Nature Medicine (2006) 12, (1294-1300))

Other Nature Medicine · August 1, 2008 Full text Cite

Consortium analysis of 7 candidate SNPs for ovarian cancer.

Journal Article Int J Cancer · July 15, 2008 The Ovarian Cancer Association Consortium selected 7 candidate single nucleotide polymorphisms (SNPs), for which there is evidence from previous studies of an association with variation in ovarian cancer or breast cancer risks. The SNPs selected for analys ... Full text Link to item Cite

Cyclin E overexpression relates to ovarian cancer histology but not to risk factors.

Journal Article Cancer Epidemiol Biomarkers Prev · July 2008 Full text Link to item Cite

Scientific innovation--pathway to progress in women's cancer.

Journal Article Gynecol Oncol · June 2008 Featured Publication Full text Link to item Cite

Gene expression determinants of ovarian cancer platinum-response in older women.

Journal Article J Clin Oncol · May 20, 2008 22059 Background: Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy, and more than half of new ovarian cancer cases arise in women over age 65. Although older women with EOC have poorer overall prognosis compared to younger women, t ... Link to item Cite

Gene expression determinants of ovarian cancer platinum-response in older women

Journal Article Journal of Clinical Oncology · May 20, 2008 Full text Cite

Hormonal risk factors for ovarian cancer in premenopausal and postmenopausal women.

Journal Article Am J Epidemiol · May 1, 2008 Ovarian cancer is most frequently diagnosed in postmenopausal women; however, the strongest risk predictors, pregnancy and oral contraceptive use, occur in most women in their twenties and thirties. Relatively few studies have examined how reproductive ris ... Full text Link to item Cite

Cyclin E overexpression in epithelial ovarian cancer characterizes an etiologic subgroup.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2008 Featured Publication BACKGROUND: The objective of this study was to determine whether cyclin E overexpression defines an etiologically distinct subgroup of ovarian cancer. METHODS: We analyzed data from 538 epithelial ovarian cancer cases and 629 controls enrolled in a populat ... Full text Link to item Cite