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Joellen Martha Schildkraut

Professor Emeritus in Family Medicine and Community Health
Family Medicine and Community Health, Prevention Research
Box 2715 Med Ctr, Durham, NC 27705
6036 Hock Plaza, 2424 Erwin Road, Durham, NC 27705

Selected Publications


Lifetime ovulatory years and risk of epithelial ovarian cancer: a multinational pooled analysis.

Journal Article J Natl Cancer Inst · May 8, 2023 BACKGROUND: The role of ovulation in epithelial ovarian cancer (EOC) is supported by the consistent protective effects of parity and oral contraceptive use. Whether these factors protect through anovulation alone remains unclear. We explored the associatio ... Full text Link to item Cite

The association between genetically elevated polyunsaturated fatty acids and risk of cancer.

Journal Article EBioMedicine · May 2023 BACKGROUND: The causal relevance of polyunsaturated fatty acids (PUFAs) for risk of site-specific cancers remains uncertain. METHODS: Using a Mendelian randomization (MR) framework, we assessed the causal relevance of PUFAs for risk of cancer in European a ... Full text Link to item Cite

The genomic landscape of familial glioma.

Journal Article Sci Adv · April 28, 2023 Glioma is a rare brain tumor with a poor prognosis. Familial glioma is a subset of glioma with a strong genetic predisposition that accounts for approximately 5% of glioma cases. We performed whole-genome sequencing on an exploratory cohort of 203 individu ... Full text Link to item Cite

Survival of epithelial ovarian cancer in Black women: a society to cell approach in the African American cancer epidemiology study (AACES).

Journal Article Cancer Causes Control · March 2023 PURPOSE: The causes for the survival disparity among Black women with epithelial ovarian cancer (EOC) are likely multi-factorial. Here we describe the African American Cancer Epidemiology Study (AACES), the largest cohort of Black women with EOC. METHODS: ... Full text Link to item Cite

Association of Frequent Aspirin Use With Ovarian Cancer Risk According to Genetic Susceptibility.

Journal Article JAMA Netw Open · February 1, 2023 IMPORTANCE: Frequent aspirin use is associated with reduced ovarian cancer risk, but it is unknown whether genetic factors modify this association. Understanding effect modifiers is important given that any use of aspirin for ovarian cancer chemoprevention ... Full text Link to item Cite

Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study.

Journal Article Br J Cancer · January 2023 BACKGROUND: Recently, we showed a >60% difference in 5-year survival for patients with tubo-ovarian high-grade serous carcinoma (HGSC) when stratified by a 101-gene mRNA expression prognostic signature. Given the varied patient outcomes, this study aimed t ... Full text Link to item Cite

Modification of the Association Between Frequent Aspirin Use and Ovarian Cancer Risk: A Meta-Analysis Using Individual-Level Data From Two Ovarian Cancer Consortia.

Journal Article J Clin Oncol · December 20, 2022 PURPOSE: Frequent aspirin use has been associated with reduced ovarian cancer risk, but no study has comprehensively assessed for effect modification. We leveraged harmonized, individual-level data from 17 studies to examine the association between frequen ... Full text Link to item Cite

Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes.

Journal Article Clin Cancer Res · December 15, 2022 PURPOSE: Advanced-stage mucinous ovarian carcinoma (MOC) has poor chemotherapy response and prognosis and lacks biomarkers to aid stage I adjuvant treatment. Differentiating primary MOC from gastrointestinal (GI) metastases to the ovary is also challenging ... Full text Link to item Cite

Copy Number Variants Are Ovarian Cancer Risk Alleles at Known and Novel Risk Loci.

Journal Article J Natl Cancer Inst · November 14, 2022 BACKGROUND: Known risk alleles for epithelial ovarian cancer (EOC) account for approximately 40% of the heritability for EOC. Copy number variants (CNVs) have not been investigated as EOC risk alleles in a large population cohort. METHODS: Single nucleotid ... Full text Link to item Cite

Racial differences in the association of body mass index and ovarian cancer risk in the OCWAA Consortium.

Journal Article Br J Cancer · November 2022 BACKGROUND: Obesity disproportionately affects African American (AA) women and has been shown to increase ovarian cancer risk, with some suggestions that the association may differ by race. METHODS: We evaluated body mass index (BMI) and invasive epithelia ... Full text Link to item Cite

Racial disparities in epithelial ovarian cancer survival: An examination of contributing factors in the Ovarian Cancer in Women of African Ancestry consortium.

Conference Int J Cancer · October 15, 2022 Black women diagnosed with epithelial ovarian cancer have poorer survival compared to white women. Factors that contribute to this disparity, aside from socioeconomic status and guideline-adherent treatment, have not yet been clearly identified. We examine ... Full text Link to item Cite

Race Differences in the Associations between Menstrual Cycle Characteristics and Epithelial Ovarian Cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · August 2, 2022 BACKGROUND: Menstrual cycle characteristics-including age at menarche and cycle length- have been associated with ovarian cancer risk in White women. However, the associations between menstrual cycle characteristics and ovarian cancer risk among Black wome ... Full text Link to item Cite

Racial Differences in the Tumor Immune Landscape and Survival of Women with High-Grade Serous Ovarian Carcinoma.

Journal Article Cancer Epidemiol Biomarkers Prev · May 4, 2022 BACKGROUND: Tumor-infiltrating lymphocytes (TIL) confer a survival benefit among patients with ovarian cancer; however, little work has been conducted in racially diverse cohorts. METHODS: The current study investigated racial differences in the tumor immu ... Full text Link to item Cite

CA-125 Levels Are Predictive of Survival in Low-Grade Serous Ovarian Cancer-A Multicenter Analysis.

Journal Article Cancers (Basel) · April 13, 2022 OBJECTIVE: Studies on low-grade serous ovarian cancer (LGSC) are limited by a low number of cases. The aim of this study was to define the prognostic significance of age, stage, and CA-125 levels on survival in a multi-institutional cohort of women with pa ... Full text Link to item Cite

Reproductive Factors Do Not Influence Survival with Ovarian Cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · April 1, 2022 BACKGROUND: Previous studies on the association between reproductive factors and ovarian cancer survival are equivocal, possibly due to small sample sizes. METHODS: Using data on 11,175 people diagnosed with primary invasive epithelial ovarian, fallopian t ... Full text Link to item Cite

Psychosocial factors associated with genetic testing status among African American women with ovarian cancer: Results from the African American Cancer Epidemiology Study.

Journal Article Cancer · March 15, 2022 BACKGROUND: Racial disparities in the uptake of cancer genetic services are well documented among African American (AA) women. Understanding the multiple social and psychological factors that can influence the uptake of genetic testing among AA women is ne ... Full text Link to item Cite

High Prediagnosis Inflammation-Related Risk Score Associated with Decreased Ovarian Cancer Survival.

Journal Article Cancer Epidemiol Biomarkers Prev · February 2022 BACKGROUND: There is suggestive evidence that inflammation is related to ovarian cancer survival. However, more research is needed to identify inflammation-related factors that are associated with ovarian cancer survival and to determine their combined eff ... Full text Link to item Cite

A whole-exome case-control association study to characterize the contribution of rare coding variation to pancreatic cancer risk

Journal Article Human Genetics and Genomics Advances · January 13, 2022 Pancreatic cancer is a deadly disease that accounts for approximately 5% of cancer deaths worldwide, with a dismal 5-year survival rate of 10%. Known genetic risk factors explain only a modest proportion of the heritable risk of pancreatic cancer. We condu ... Full text Cite

Pleiotropic MLLT10 variation confers risk of meningioma and estrogen-mediated cancers

Conference Neuro-Oncology Advances · January 1, 2022 Background: Risk of tumors of the breast, ovary, and meninges has been associated with hormonal factors and with one another. Genome-wide association studies (GWAS) identified a meningioma risk locus on 10p12 near previous GWAS hits for breast and ovarian ... Full text Cite

Endometriosis and menopausal hormone therapy impact the hysterectomy-ovarian cancer association.

Journal Article Gynecol Oncol · January 2022 OBJECTIVE: To evaluate the association between hysterectomy and ovarian cancer, and to understand how hormone therapy (HT) use and endometriosis affect this association. METHODS: We conducted a pooled analysis of self-reported data from 11 case-control stu ... Full text Link to item Cite

Lifetime ovulatory years and risk of epithelial ovarian cancer: a multinational pooled analysis.

Journal Article J Natl Cancer Inst · May 8, 2023 BACKGROUND: The role of ovulation in epithelial ovarian cancer (EOC) is supported by the consistent protective effects of parity and oral contraceptive use. Whether these factors protect through anovulation alone remains unclear. We explored the associatio ... Full text Link to item Cite

The association between genetically elevated polyunsaturated fatty acids and risk of cancer.

Journal Article EBioMedicine · May 2023 BACKGROUND: The causal relevance of polyunsaturated fatty acids (PUFAs) for risk of site-specific cancers remains uncertain. METHODS: Using a Mendelian randomization (MR) framework, we assessed the causal relevance of PUFAs for risk of cancer in European a ... Full text Link to item Cite

The genomic landscape of familial glioma.

Journal Article Sci Adv · April 28, 2023 Glioma is a rare brain tumor with a poor prognosis. Familial glioma is a subset of glioma with a strong genetic predisposition that accounts for approximately 5% of glioma cases. We performed whole-genome sequencing on an exploratory cohort of 203 individu ... Full text Link to item Cite

Survival of epithelial ovarian cancer in Black women: a society to cell approach in the African American cancer epidemiology study (AACES).

Journal Article Cancer Causes Control · March 2023 PURPOSE: The causes for the survival disparity among Black women with epithelial ovarian cancer (EOC) are likely multi-factorial. Here we describe the African American Cancer Epidemiology Study (AACES), the largest cohort of Black women with EOC. METHODS: ... Full text Link to item Cite

Association of Frequent Aspirin Use With Ovarian Cancer Risk According to Genetic Susceptibility.

Journal Article JAMA Netw Open · February 1, 2023 IMPORTANCE: Frequent aspirin use is associated with reduced ovarian cancer risk, but it is unknown whether genetic factors modify this association. Understanding effect modifiers is important given that any use of aspirin for ovarian cancer chemoprevention ... Full text Link to item Cite

Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study.

Journal Article Br J Cancer · January 2023 BACKGROUND: Recently, we showed a >60% difference in 5-year survival for patients with tubo-ovarian high-grade serous carcinoma (HGSC) when stratified by a 101-gene mRNA expression prognostic signature. Given the varied patient outcomes, this study aimed t ... Full text Link to item Cite

Modification of the Association Between Frequent Aspirin Use and Ovarian Cancer Risk: A Meta-Analysis Using Individual-Level Data From Two Ovarian Cancer Consortia.

Journal Article J Clin Oncol · December 20, 2022 PURPOSE: Frequent aspirin use has been associated with reduced ovarian cancer risk, but no study has comprehensively assessed for effect modification. We leveraged harmonized, individual-level data from 17 studies to examine the association between frequen ... Full text Link to item Cite

Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes.

Journal Article Clin Cancer Res · December 15, 2022 PURPOSE: Advanced-stage mucinous ovarian carcinoma (MOC) has poor chemotherapy response and prognosis and lacks biomarkers to aid stage I adjuvant treatment. Differentiating primary MOC from gastrointestinal (GI) metastases to the ovary is also challenging ... Full text Link to item Cite

Copy Number Variants Are Ovarian Cancer Risk Alleles at Known and Novel Risk Loci.

Journal Article J Natl Cancer Inst · November 14, 2022 BACKGROUND: Known risk alleles for epithelial ovarian cancer (EOC) account for approximately 40% of the heritability for EOC. Copy number variants (CNVs) have not been investigated as EOC risk alleles in a large population cohort. METHODS: Single nucleotid ... Full text Link to item Cite

Racial differences in the association of body mass index and ovarian cancer risk in the OCWAA Consortium.

Journal Article Br J Cancer · November 2022 BACKGROUND: Obesity disproportionately affects African American (AA) women and has been shown to increase ovarian cancer risk, with some suggestions that the association may differ by race. METHODS: We evaluated body mass index (BMI) and invasive epithelia ... Full text Link to item Cite

Racial disparities in epithelial ovarian cancer survival: An examination of contributing factors in the Ovarian Cancer in Women of African Ancestry consortium.

Conference Int J Cancer · October 15, 2022 Black women diagnosed with epithelial ovarian cancer have poorer survival compared to white women. Factors that contribute to this disparity, aside from socioeconomic status and guideline-adherent treatment, have not yet been clearly identified. We examine ... Full text Link to item Cite

Race Differences in the Associations between Menstrual Cycle Characteristics and Epithelial Ovarian Cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · August 2, 2022 BACKGROUND: Menstrual cycle characteristics-including age at menarche and cycle length- have been associated with ovarian cancer risk in White women. However, the associations between menstrual cycle characteristics and ovarian cancer risk among Black wome ... Full text Link to item Cite

Racial Differences in the Tumor Immune Landscape and Survival of Women with High-Grade Serous Ovarian Carcinoma.

Journal Article Cancer Epidemiol Biomarkers Prev · May 4, 2022 BACKGROUND: Tumor-infiltrating lymphocytes (TIL) confer a survival benefit among patients with ovarian cancer; however, little work has been conducted in racially diverse cohorts. METHODS: The current study investigated racial differences in the tumor immu ... Full text Link to item Cite

CA-125 Levels Are Predictive of Survival in Low-Grade Serous Ovarian Cancer-A Multicenter Analysis.

Journal Article Cancers (Basel) · April 13, 2022 OBJECTIVE: Studies on low-grade serous ovarian cancer (LGSC) are limited by a low number of cases. The aim of this study was to define the prognostic significance of age, stage, and CA-125 levels on survival in a multi-institutional cohort of women with pa ... Full text Link to item Cite

Reproductive Factors Do Not Influence Survival with Ovarian Cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · April 1, 2022 BACKGROUND: Previous studies on the association between reproductive factors and ovarian cancer survival are equivocal, possibly due to small sample sizes. METHODS: Using data on 11,175 people diagnosed with primary invasive epithelial ovarian, fallopian t ... Full text Link to item Cite

Psychosocial factors associated with genetic testing status among African American women with ovarian cancer: Results from the African American Cancer Epidemiology Study.

Journal Article Cancer · March 15, 2022 BACKGROUND: Racial disparities in the uptake of cancer genetic services are well documented among African American (AA) women. Understanding the multiple social and psychological factors that can influence the uptake of genetic testing among AA women is ne ... Full text Link to item Cite

High Prediagnosis Inflammation-Related Risk Score Associated with Decreased Ovarian Cancer Survival.

Journal Article Cancer Epidemiol Biomarkers Prev · February 2022 BACKGROUND: There is suggestive evidence that inflammation is related to ovarian cancer survival. However, more research is needed to identify inflammation-related factors that are associated with ovarian cancer survival and to determine their combined eff ... Full text Link to item Cite

A whole-exome case-control association study to characterize the contribution of rare coding variation to pancreatic cancer risk

Journal Article Human Genetics and Genomics Advances · January 13, 2022 Pancreatic cancer is a deadly disease that accounts for approximately 5% of cancer deaths worldwide, with a dismal 5-year survival rate of 10%. Known genetic risk factors explain only a modest proportion of the heritable risk of pancreatic cancer. We condu ... Full text Cite

Pleiotropic MLLT10 variation confers risk of meningioma and estrogen-mediated cancers

Conference Neuro-Oncology Advances · January 1, 2022 Background: Risk of tumors of the breast, ovary, and meninges has been associated with hormonal factors and with one another. Genome-wide association studies (GWAS) identified a meningioma risk locus on 10p12 near previous GWAS hits for breast and ovarian ... Full text Cite

Endometriosis and menopausal hormone therapy impact the hysterectomy-ovarian cancer association.

Journal Article Gynecol Oncol · January 2022 OBJECTIVE: To evaluate the association between hysterectomy and ovarian cancer, and to understand how hormone therapy (HT) use and endometriosis affect this association. METHODS: We conducted a pooled analysis of self-reported data from 11 case-control stu ... Full text Link to item Cite

Partitioned glioma heritability shows subtype-specific enrichment in immune cells.

Journal Article Neuro Oncol · August 2, 2021 BACKGROUND: Epidemiological studies of adult glioma have identified genetic syndromes and 25 heritable risk loci that modify individual risk for glioma, as well increased risk in association with exposure to ionizing radiation and decreased risk in associa ... Full text Link to item Cite

Challenges and Opportunities in the Statistical Analysis of Multiplex Immunofluorescence Data.

Journal Article Cancers (Basel) · June 17, 2021 Immune modulation is considered a hallmark of cancer initiation and progression. The recent development of immunotherapies has ushered in a new era of cancer treatment. These therapeutics have led to revolutionary breakthroughs; however, the efficacy of im ... Full text Link to item Cite

First- and second-degree family history of ovarian and breast cancer in relation to risk of invasive ovarian cancer in African American and white women.

Journal Article Int J Cancer · June 15, 2021 Family history (FH) of ovarian cancer and breast cancer are well-established risk factors for ovarian cancer, but few studies have examined this association in African American (AA) and white women by histotype. We assessed first- and second-degree FH of o ... Full text Link to item Cite

Racial Differences in Population Attributable Risk for Epithelial Ovarian Cancer in the OCWAA Consortium.

Journal Article J Natl Cancer Inst · June 1, 2021 BACKGROUND: The causes of racial disparities in epithelial ovarian cancer (EOC) incidence remain unclear. Differences in the prevalence of ovarian cancer risk factors may explain disparities in EOC incidence among African American (AA) and White women. MET ... Full text Link to item Cite

Population-based targeted sequencing of 54 candidate genes identifies PALB2 as a susceptibility gene for high-grade serous ovarian cancer.

Journal Article J Med Genet · May 2021 PURPOSE: The known epithelial ovarian cancer (EOC) susceptibility genes account for less than 50% of the heritable risk of ovarian cancer suggesting that other susceptibility genes exist. The aim of this study was to evaluate the contribution to ovarian ca ... Full text Link to item Cite

Depot-Medroxyprogesterone Acetate Use Is Associated with Decreased Risk of Ovarian Cancer: The Mounting Evidence of a Protective Role of Progestins.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2021 BACKGROUND: Combined oral contraceptive use is associated with a decreased risk of invasive epithelial ovarian cancer (ovarian cancer). There is suggestive evidence of an inverse association between progestin-only contraceptive use and ovarian cancer risk, ... Full text Link to item Cite

Expanding Our Understanding of Ovarian Cancer Risk: The Role of Incomplete Pregnancies.

Journal Article J Natl Cancer Inst · March 1, 2021 BACKGROUND: Parity is associated with decreased risk of invasive ovarian cancer; however, the relationship between incomplete pregnancies and invasive ovarian cancer risk is unclear. This relationship was examined using 15 case-control studies from the Ova ... Full text Link to item Cite

Genetically predicted circulating protein biomarkers and ovarian cancer risk.

Journal Article Gynecol Oncol · February 2021 OBJECTIVE: Most women with epithelial ovarian cancer (EOC) are diagnosed after the disease has metastasized and survival in this group remains poor. Circulating proteins associated with the risk of developing EOC have the potential to serve as biomarkers f ... Full text Link to item Cite

Searching for causal relationships of glioma: a phenome-wide Mendelian randomisation study.

Journal Article British journal of cancer · January 2021 BackgroundThe aetiology of glioma is poorly understood. Summary data from genome-wide association studies (GWAS) can be used in a Mendelian randomisation (MR) phenome-wide association study (PheWAS) to search for glioma risk factors.Methods Full text Cite

Offspring sex and risk of epithelial ovarian cancer: a multinational pooled analysis of 12 case-control studies.

Journal Article Eur J Epidemiol · November 2020 While childbearing protects against risk of epithelial ovarian cancer (EOC), few studies have explored the impact on maternal EOC risk of sex of offspring, which may affect the maternal environment during pregnancy. We performed a pooled analysis among par ... Full text Link to item Cite

Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma.

Journal Article Acta Neuropathol Commun · October 28, 2020 Ependymoma is the third most common brain tumor in children, with well-described molecular characterization but poorly understood underlying germline risk factors. To investigate whether genetic predisposition to longer telomere length influences ependymom ... Full text Link to item Cite

Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers.

Journal Article Nat Commun · July 3, 2020 Genome-wide association studies (GWAS) have led to the identification of hundreds of susceptibility loci across cancers, but the impact of further studies remains uncertain. Here we analyse summary-level data from GWAS of European ancestry across fourteen ... Full text Link to item Cite

Cardiometabolic comorbidities and epithelial ovarian cancer risk among African-American women in the African-American Cancer Epidemiology Study (AACES).

Journal Article Gynecol Oncol · July 2020 BACKGROUND: Studies that have examined the association between cardiovascular comorbidities and epithelial ovarian cancer (EOC) have yielded inconsistent results. It remains unknown whether cardiometabolic disease is associated with EOC in African American ... Full text Link to item Cite

Identification of novel epithelial ovarian cancer loci in women of African ancestry.

Journal Article Int J Cancer · June 1, 2020 Women of African ancestry have lower incidence of epithelial ovarian cancer (EOC) yet worse survival compared to women of European ancestry. We conducted a genome-wide association study in African ancestry women with 755 EOC cases, including 537 high-grade ... Full text Link to item Cite

Association Between Breastfeeding and Ovarian Cancer Risk.

Journal Article JAMA Oncol · June 1, 2020 IMPORTANCE: Breastfeeding has been associated with a reduced risk of epithelial ovarian cancer in multiple studies, but others showed no association. Whether risk reduction extends beyond that provided by pregnancy alone or differs by histotype is unclear. ... Full text Link to item Cite

Lack of association between modifiable exposures and glioma risk: a Mendelian randomization analysis.

Journal Article Neuro Oncol · February 20, 2020 BACKGROUND: The etiological basis of glioma is poorly understood. We have used genetic markers in a Mendelian randomization (MR) framework to examine if lifestyle, cardiometabolic, and inflammatory factors influence the risk of glioma. This methodology red ... Full text Link to item Cite

Glioma risk associated with extent of estimated European genetic ancestry in African Americans and Hispanics.

Journal Article Int J Cancer · February 1, 2020 Glioma incidence is highest in non-Hispanic Whites, and to date, glioma genome-wide association studies (GWAS) to date have only included European ancestry (EA) populations. African Americans and Hispanics in the US have varying proportions of EA, African ... Full text Link to item Cite

Racial/ethnic disparities in ovarian cancer research.

Chapter · 2020 Ovarian cancer is one of the most fatal cancers diagnosed in women in the United States (U.S.). Data from national databases, including the Surveillance Epidemiology and End Results (SEER) program, show racial/ethnic differences in risk and survival of epi ... Full text Link to item Cite

Perceived discrimination, trust in physicians, and prolonged symptom duration before ovarian cancer diagnosis in the African American Cancer Epidemiology Study.

Journal Article Cancer · December 15, 2019 BACKGROUND: Discrimination and trust are known barriers to accessing health care. Despite well-documented racial disparities in the ovarian cancer care continuum, the role of these barriers has not been examined. This study evaluated the association of eve ... Full text Link to item Cite

Role of monoamine-oxidase-A-gene variation in the development of glioblastoma in males: a case control study.

Journal Article J Neurooncol · November 2019 BACKGROUND: The Mono-amine oxidase-A (MAO-A) enzyme is involved in the degradation and regulation of catecholamines such as serotonin, dopamine, epinephrine and nor-epinephrine. Preclinical studies suggest that this enzyme may contribute to an environment ... Full text Link to item Cite

Circulating vitamin D concentrations and risk of breast and prostate cancer: a Mendelian randomization study.

Journal Article Int J Epidemiol · October 1, 2019 BACKGROUND: Observational studies have suggested an association between circulating vitamin D concentrations [25(OH)D] and risk of breast and prostate cancer, which was not supported by a recent Mendelian randomization (MR) analysis comprising 15 748 breas ... Full text Link to item Cite

Prediagnostic Proinflammatory Dietary Potential Is Associated with All-Cause Mortality among African-American Women with High-Grade Serous Ovarian Carcinoma.

Journal Article J Nutr · September 1, 2019 BACKGROUND: Chronic inflammation is associated with ovarian carcinogenesis; yet, the impact of inflammatory-related exposures on outcomes has been understudied. OBJECTIVE: Given the poor survival of women diagnosed with ovarian cancer, especially African-A ... Full text Link to item Cite

Ovarian Cancer in Women of African Ancestry (OCWAA) consortium: a resource of harmonized data from eight epidemiologic studies of African American and white women.

Journal Article Cancer Causes Control · September 2019 PURPOSE: Although the incidence rate of epithelial ovarian cancer (EOC) is somewhat lower in African American (AA) than white women, survival is worse. The Ovarian Cancer in Women of African Ancestry (OCWAA) consortium will overcome small, study-specific s ... Full text Link to item Cite

Genome-wide Analysis of Common Copy Number Variation and Epithelial Ovarian Cancer Risk.

Journal Article Cancer Epidemiol Biomarkers Prev · July 2019 BACKGROUND: Germline DNA copy number variation (CNV) is a ubiquitous source of genetic variation and remains largely unexplored in association with epithelial ovarian cancer (EOC) risk. METHODS: CNV was quantified in the DNA of approximately 3,500 cases an ... Full text Link to item Cite

Association between genetically predicted polycystic ovary syndrome and ovarian cancer: a Mendelian randomization study.

Journal Article Int J Epidemiol · June 1, 2019 BACKGROUND: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder with an estimated prevalence of 4-21% in reproductive aged women. Recently, the Ovarian Cancer Association Consortium (OCAC) reported a decreased risk of invasive ovarian cancer a ... Full text Link to item Cite

Publisher Correction: Mendelian randomisation study of the relationship between vitamin D and risk of glioma.

Journal Article Sci Rep · May 23, 2019 A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ... Full text Link to item Cite

A comprehensive gene-environment interaction analysis in Ovarian Cancer using genome-wide significant common variants.

Journal Article Int J Cancer · May 1, 2019 As a follow-up to genome-wide association analysis of common variants associated with ovarian carcinoma (cancer), our study considers seven well-known ovarian cancer risk factors and their interactions with 28 genome-wide significant common genetic variant ... Full text Link to item Cite

Longer genotypically-estimated leukocyte telomere length is associated with increased meningioma risk.

Journal Article J Neurooncol · May 2019 PURPOSE: Telomere length-associated SNPs have been associated with incidence and survival rates for malignant brain tumors such as glioma. Here, we study the influence of genetically determined lymphocyte telomere length (LTL) by comparing telomerase assoc ... Full text Link to item Cite

Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women.

Journal Article Cancer Med · May 2019 An association between genetic variants in the vitamin D receptor (VDR) gene and epithelial ovarian cancer (EOC) was previously reported in women of African ancestry (AA). We sought to examine associations between genetic variants in VDR and additional gen ... Full text Link to item Cite

Effect of Cultural, Folk, and Religious Beliefs and Practices on Delays in Diagnosis of Ovarian Cancer in African American Women.

Journal Article J Womens Health (Larchmt) · April 2019 BACKGROUND: Certain cultural, folk, and religious beliefs that are more common among African Americans (AAs) have been associated with later-stage breast cancer. It is unknown if these beliefs are similarly associated with delays in diagnosis of ovarian ca ... Full text Link to item Cite

Targetable Immune Regulatory Molecule Expression in High-Grade Serous Ovarian Carcinomas in African American Women: A Study of PD-L1 and IDO in 112 Cases From the African American Cancer Epidemiology Study (AACES).

Journal Article Int J Gynecol Pathol · March 2019 African American women with high-grade serous ovarian carcinoma have worse outcomes compared with women of European descent. Although the discrepancy is partially attributed to differences in access to care, the tumor immune microenvironment may also contr ... Full text Link to item Cite

Aspirin, NSAIDs, and Glioma Risk: Original Data from the Glioma International Case-Control Study and a Meta-analysis.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2019 BACKGROUND: There have been few studies of sufficient size to address the relationship between glioma risk and the use of aspirin or NSAIDs, and results have been conflicting. The purpose of this study was to examine the associations between glioma and asp ... Full text Link to item Cite

Individual, Social, and Societal Correlates of Health-Related Quality of Life Among African American Survivors of Ovarian Cancer: Results from the African American Cancer Epidemiology Study.

Journal Article J Womens Health (Larchmt) · February 2019 OBJECTIVE: While the incidence of epithelial ovarian cancer (EOC) is lower among African American (AA) women compared with European American (EA) women, AA women have markedly worse outcomes. In this study, we describe individual, social, and societal fact ... Full text Link to item Cite

Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk.

Journal Article Cancer Res · February 1, 2019 DNA methylation is instrumental for gene regulation. Global changes in the epigenetic landscape have been recognized as a hallmark of cancer. However, the role of DNA methylation in epithelial ovarian cancer (EOC) remains unclear. In this study, high-densi ... Full text Link to item Cite

Mendelian randomization provides support for obesity as a risk factor for meningioma.

Journal Article Sci Rep · January 22, 2019 Little is known about the causes of meningioma. Obesity and obesity-related traits have been reported in several epidemiological observational studies to be risk factors for meningioma. We performed an analysis of genetic variants associated with obesity-r ... Full text Link to item Cite

Invasive Epithelial Ovarian Cancer Survival by Histotype and Disease Stage.

Journal Article J Natl Cancer Inst · January 1, 2019 BACKGROUND: The understanding of ovarian cancer pathogenesis has recently shifted to recognize distinct changes in how ovarian cancer histotypes are defined. Using the 2014 World Health Organization (WHO) diagnostic guidelines, we classified ovarian cancer ... Full text Link to item Cite

Sex-specific gene and pathway modeling of inherited glioma risk.

Journal Article Neuro Oncol · January 1, 2019 BACKGROUND: To date, genome-wide association studies (GWAS) have identified 25 risk variants for glioma, explaining 30% of heritable risk. Most histologies occur with significantly higher incidence in males, and this difference is not explained by currentl ... Full text Link to item Cite

Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age.

Journal Article Int J Cancer · November 15, 2018 Glioblastoma (GBM) is the most common malignant brain tumor in the United States. Incidence of GBM increases with age, and younger age-at-diagnosis is significantly associated with improved prognosis. While the relationship between candidate GBM risk SNPs ... Full text Link to item Cite

Benign gynecologic conditions are associated with ovarian cancer risk in African-American women: a case-control study.

Journal Article Cancer Causes Control · November 2018 BACKGROUND: The association between common benign gynecologic conditions and ovarian cancer remains under-studied in African Americans. Therefore, we examine the association between self-reported history of benign gynecologic conditions and epithelial ovar ... Full text Link to item Cite

Genome-wide association analysis identifies a meningioma risk locus at 11p15.5.

Journal Article Neuro Oncol · October 9, 2018 BACKGROUND: Meningiomas are adult brain tumors originating in the meningeal coverings of the brain and spinal cord, with significant heritable basis. Genome-wide association studies (GWAS) have previously identified only a single risk locus for meningioma, ... Full text Link to item Cite

Association of p16 expression with prognosis varies across ovarian carcinoma histotypes: an Ovarian Tumor Tissue Analysis consortium study.

Journal Article J Pathol Clin Res · October 2018 We aimed to validate the prognostic association of p16 expression in ovarian high-grade serous carcinomas (HGSC) and to explore it in other ovarian carcinoma histotypes. p16 protein expression was assessed by clinical-grade immunohistochemistry in 6525 ova ... Full text Link to item Cite

Histotype classification of ovarian carcinoma: A comparison of approaches.

Journal Article Gynecol Oncol · October 2018 OBJECTIVE: Major changes in the classification of ovarian carcinoma histotypes occurred over the last two decades, resulting in the current 2014 World Health Organization (WHO) diagnostic criteria that recognize five principal histotypes: high-grade serous ... Full text Link to item Cite

A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk.

Journal Article Cancer Res · September 15, 2018 Large-scale genome-wide association studies (GWAS) have identified approximately 35 loci associated with epithelial ovarian cancer (EOC) risk. The majority of GWAS-identified disease susceptibility variants are located in noncoding regions, and causal gene ... Full text Link to item Cite

rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology.

Journal Article Int J Mol Sci · August 21, 2018 Thymidylate synthase (TYMS) is a crucial enzyme for DNA synthesis. TYMS expression is regulated by its antisense mRNA, ENOSF1. Disrupted regulation may promote uncontrolled DNA synthesis and tumor growth. We sought to replicate our previously reported asso ... Full text Link to item Cite

Glioma-related seizures in relation to histopathological subtypes: a report from the glioma international case-control study.

Journal Article J Neurol · June 2018 BACKGROUND: The purpose of this study was to evaluate the distribution of glioma-related seizures and seizure control at the time of tumor diagnosis with respect to tumor histologic subtypes, tumor treatment and patient characteristics, and to compare seiz ... Full text Link to item Cite

Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.

Journal Article Sci Rep · May 9, 2018 Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma genome-wide association studie ... Full text Link to item Cite

Common Genetic Variation and Susceptibility to Ovarian Cancer: Current Insights and Future Directions.

Journal Article Cancer Epidemiol Biomarkers Prev · April 2018 In this review, we summarize current progress in the genetic epidemiology of epithelial ovarian cancer (EOC), focusing exclusively on elucidating the role of common germline genetic variation in conferring susceptibility to EOC. We provide an overview of t ... Full text Link to item Cite

Maternal vitamin D, DNA methylation at imprint regulatory regions and offspring weight at birth, 1 year and 3 years.

Journal Article Int J Obes (Lond) · April 2018 BACKGROUND/OBJECTIVE: Vitamin D deficiency during pregnancy is associated with poor birth outcomes in some studies, but few have examined weight beyond birth. In addition, little is known about how vitamin D influences DNA methylation of regulatory regions ... Full text Link to item Cite

Impact of age at diagnosis on racial disparities in endometrial cancer patients.

Journal Article Gynecol Oncol · April 2018 INTRODUCTION: Although black patients with endometrial cancer (EC) have worse survival compared with white patients, the interaction between age/race has not been examined. The primary objective was to evaluate the impact of age at diagnosis on racial disp ... Full text Link to item Cite

Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies.

Journal Article Int J Epidemiol · April 1, 2018 BACKGROUND: Ovarian cancer incidence differs substantially by race/ethnicity, but the reasons for this are not well understood. Data were pooled from the African American Cancer Epidemiology Study (AACES) and 11 case-control studies in the Ovarian Cancer A ... Full text Link to item Cite

Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study.

Journal Article Br J Cancer · April 2018 BACKGROUND: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bia ... Full text Link to item Cite

Influence of obesity-related risk factors in the aetiology of glioma.

Journal Article Br J Cancer · April 2018 BACKGROUND: Obesity and related factors have been implicated as possible aetiological factors for the development of glioma in epidemiological observation studies. We used genetic markers in a Mendelian randomisation framework to examine whether obesity-re ... Full text Link to item Cite

Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study.

Journal Article Int J Epidemiol · April 1, 2018 BACKGROUND: Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations ar ... Full text Link to item Cite

Impact of atopy on risk of glioma: a Mendelian randomisation study.

Journal Article BMC Med · March 15, 2018 BACKGROUND: An inverse relationship between allergies with glioma risk has been reported in several but not all epidemiological observational studies. We performed an analysis of genetic variants associated with atopy to assess the relationship with glioma ... Full text Link to item Cite

Mendelian randomisation study of the relationship between vitamin D and risk of glioma.

Journal Article Sci Rep · February 5, 2018 To examine for a causal relationship between vitamin D and glioma risk we performed an analysis of genetic variants associated with serum 25-hydroxyvitamin D (25(OH)D) levels using Mendelian randomisation (MR), an approach unaffected by biases from confoun ... Full text Link to item Cite

Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence.

Journal Article Am J Epidemiol · February 1, 2018 There have been recent proposals advocating the use of additive gene-environment interaction instead of the widely used multiplicative scale, as a more relevant public health measure. Using gene-environment independence enhances statistical power for testi ... Full text Link to item Cite

Menstrual pain and risk of epithelial ovarian cancer: Results from the Ovarian Cancer Association Consortium.

Journal Article International journal of cancer · February 2018 Menstrual pain, a common gynecological condition, has been associated with increased risk of ovarian cancer in some, but not all studies. Furthermore, potential variations in the association between menstrual pain and ovarian cancer by histologic subtype h ... Full text Cite

Polycystic Ovary Syndrome, Oligomenorrhea, and Risk of Ovarian Cancer Histotypes: Evidence from the Ovarian Cancer Association Consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · February 2018 Background: Polycystic ovary syndrome (PCOS), and one of its distinguishing characteristics, oligomenorrhea, have both been associated with ovarian cancer risk in some but not all studies. However, these associations have been rarely examined by ovarian ca ... Full text Link to item Cite

Ovarian cancer risk, ALDH2 polymorphism and alcohol drinking: Asian data from the Ovarian Cancer Association Consortium.

Journal Article Cancer Sci · February 2018 The aldehyde dehydrogenase 2 (ALDH2) polymorphism rs671 (Glu504Lys) causes ALDH2 inactivation and adverse acetaldehyde exposure among Asians, but little is known of the association between alcohol consumption and rs671 and ovarian cancer (OvCa) in Asians. ... Full text Link to item Cite

Quality of life after surgery for intracranial meningioma.

Journal Article Cancer · January 2018 BackgroundTo the authors' knowledge, limited data exist regarding long-term quality of life (QOL) for patients diagnosed with intracranial meningioma.MethodsThe data in the current study concerned 1722 meningioma cases diagnosed among res ... Full text Cite

Recreational physical activity and survival in African-American women with ovarian cancer.

Journal Article Cancer Causes Control · January 2018 PURPOSE: While recreational physical activity (RPA) has been associated with reduced mortality in breast, colorectal, and prostate cancers, evidence for epithelial ovarian cancer (EOC) is limited. Most EOC studies have been in predominantly white populatio ... Full text Link to item Cite

Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility.

Journal Article PLoS One · 2018 Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer mortality in American women. Normal ovarian physiology is intricately connected to small GTP binding proteins of the Ras superfamily (Ras, Rho, Rab, Arf, and Ran) which govern processes s ... Full text Link to item Cite

Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study.

Journal Article BMJ · October 31, 2017 Objective To determine if circulating concentrations of vitamin D are causally associated with risk of cancer.Design Mendelian randomisation study.Setting Large genetic epidemiology networks (the Genetic Associations and Mechanisms in Oncology (GAME-ON), t ... Full text Link to item Cite

Tubal ligation and ovarian cancer risk in African American women.

Journal Article Cancer Causes Control · October 2017 PURPOSE: Tubal ligation has been associated with reduced risk of epithelial ovarian cancer (EOC) in studies of primarily white women, but less is known about the association in African American (AA) women. We sought to evaluate the associations among 597 i ... Full text Link to item Cite

Current Gaps in Ovarian Cancer Epidemiology: The Need for New Population-Based Research.

Journal Article J Natl Cancer Inst · October 1, 2017 With recent ovarian cancer screening studies showing no clinically significant mortality benefit, preventing this disease, identifying high-risk populations, and extending survival remain priorities. However, several challenges are impeding progress in ova ... Full text Link to item Cite

History of thyroid disease and survival of ovarian cancer patients: results from the Ovarian Cancer Association Consortium, a brief report.

Journal Article Br J Cancer · September 26, 2017 BACKGROUND: Findings from in vitro studies suggest that increased exposure to thyroid hormones can influence progression of ovarian tumours. However, epidemiologic evidence on this topic is limited. METHODS: We pooled data from 11 studies from the Ovarian ... Full text Link to item Cite

History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · September 2017 Background: Comorbidities can affect survival of ovarian cancer patients by influencing treatment efficacy. However, little evidence exists on the association between individual concurrent comorbidities and prognosis in ovarian cancer patients.Methods: Amo ... Full text Link to item Cite

Correlation between germline mutations in MMR genes and microsatellite instability in ovarian cancer specimens.

Journal Article Fam Cancer · July 2017 A high proportion of ovarian cancers from women who carry germline mutations in mismatch repair (MMR) genes demonstrate microsatellite instability (MSI). The utility of pre-screening ovarian cancer specimens for MSI to identify potential patients for germl ... Full text Link to item Cite

Premenopausal Hysterectomy and Risk of Ovarian Cancer in African-American Women.

Journal Article Am J Epidemiol · July 1, 2017 Although the inverse association between hysterectomy and epithelial ovarian cancer (EOC) was considered well established, investigators in recent studies including women diagnosed after 2000 have observed modest increases in risk. Most studies have been c ... Full text Link to item Cite

Cigarette smoking and the association with serous ovarian cancer in African American women: African American Cancer Epidemiology Study (AACES).

Journal Article Cancer Causes Control · July 2017 BACKGROUND: Smoking is a risk factor for mucinous ovarian cancer (OvCa) in Caucasians. Whether a similar association exists in African Americans (AA) is unknown. METHODS: We conducted a population-based case-control study of incident OvCa in AA women acros ... Full text Link to item Cite

Dietary Quality and Ovarian Cancer Risk in African-American Women.

Journal Article Am J Epidemiol · June 15, 2017 This study evaluated 3 index-based dietary patterns-Healthy Eating Index (HEI)-2005, HEI-2010, and Alternate Healthy Eating Index (AHEI)-2010-in relation to ovarian cancer risk in African-American women. The study was conducted among 415 ovarian cancer cas ... Full text Link to item Cite

Analyses of germline variants associated with ovarian cancer survival identify functional candidates at the 1q22 and 19p12 outcome loci.

Journal Article Oncotarget · June 15, 2017 We previously identified associations with ovarian cancer outcome at five genetic loci. To identify putatively causal genetic variants and target genes, we prioritized two ovarian outcome loci (1q22 and 19p12) for further study. Bioinformatic and functiona ... Full text Link to item Cite

Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies.

Journal Article Int J Cancer · June 1, 2017 Cigarette smoking is associated with an increased risk of developing mucinous ovarian tumors but whether it is associated with ovarian cancer survival overall or for the different histotypes is unestablished. Furthermore, it is unknown whether the associat ... Full text Link to item Cite

Lifetime number of ovulatory cycles and epithelial ovarian cancer risk in African American women.

Journal Article Cancer Causes Control · May 2017 PURPOSE: Incessant ovulation has been consistently linked to epithelial ovarian cancer (EOC). Although reproductive characteristics differ substantially by race, the association between incessant ovulation and EOC has been evaluated only in populations of ... Full text Link to item Cite

History of hypertension, heart disease, and diabetes and ovarian cancer patient survival: evidence from the ovarian cancer association consortium.

Journal Article Cancer Causes Control · May 2017 PURPOSE: Survival following ovarian cancer diagnosis is generally low; understanding factors related to prognosis could be important to optimize treatment. The role of previously diagnosed comorbidities and use of medications for those conditions in relati ... Full text Link to item Cite

Ovarian cancer epidemiology in the era of collaborative team science.

Journal Article Cancer Causes Control · May 2017 PURPOSE: Over the past decade, a number of consortia have formed to further investigate genetic associations, pathogenesis, and epidemiologic risk and prognostic factors for ovarian cancer. Here, we review the benefits that ovarian cancer consortia provide ... Full text Link to item Cite

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.

Journal Article Nat Genet · May 2017 To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for d ... Full text Link to item Cite

Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium.

Journal Article Br J Cancer · April 25, 2017 BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with improved survival in some cancers, but evidence for ovarian cancer is limited. METHODS: Pooling individual-level data from 12 Ovarian Cancer Association Consortium studies, ... Full text Link to item Cite

Supplemental Selenium May Decrease Ovarian Cancer Risk in African-American Women.

Journal Article J Nutr · April 2017 Background: To our knowledge, no previous study has evaluated the associations of antioxidant intake with the risk of ovarian cancer in African-American women, who are known to have high mortality from the disease.Objective: We sought to evaluate these ass ... Full text Link to item Cite

No Evidence That Genetic Variation in the Myeloid-Derived Suppressor Cell Pathway Influences Ovarian Cancer Survival.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2017 Background: The precise mechanism by which the immune system is adversely affected in cancer patients remains poorly understood, but the accumulation of immunosuppressive/protumorigenic myeloid-derived suppressor cells (MDSCs) is thought to be a prominent ... Full text Link to item Cite

Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci.

Journal Article Br J Cancer · February 14, 2017 BACKGROUND: Genome-wide association studies (GWAS) have identified 18 loci associated with serous ovarian cancer (SOC) susceptibility but the biological mechanisms driving these findings remain poorly characterised. Germline cancer risk loci may be enriche ... Full text Link to item Cite

Adherence to Recommended Risk Management among Unaffected Women with a BRCA Mutation.

Journal Article J Genet Couns · February 2017 Identifying unaffected women with a BRCA mutation can have a significant individual and population health impact on morbidity and mortality if these women adhere to guidelines for managing cancer risk. But, little is known about whether such women are adhe ... Full text Link to item Cite

Dietary inflammatory index and risk of epithelial ovarian cancer in African American women.

Journal Article Int J Cancer · February 1, 2017 Chronic inflammation has been implicated in the development of epithelial ovarian cancer (EOC); yet the contribution of inflammatory foods and nutrients to EOC risk has been understudied. We investigated the association between the dietary inflammatory ind ... Full text Link to item Cite

Pelvic Inflammatory Disease and the Risk of Ovarian Cancer and Borderline Ovarian Tumors: A Pooled Analysis of 13 Case-Control Studies.

Journal Article Am J Epidemiol · January 1, 2017 Inflammation has been implicated in ovarian carcinogenesis. However, studies investigating the association between pelvic inflammatory disease (PID) and ovarian cancer risk are few and inconsistent. We investigated the association between PID and the risk ... Full text Link to item Cite

Integration of Population-Level Genotype Data with Functional Annotation Reveals Over-Representation of Long Noncoding RNAs at Ovarian Cancer Susceptibility Loci.

Journal Article Cancer Epidemiol Biomarkers Prev · January 2017 BACKGROUND: Genome-wide association studies (GWAS) have identified multiple loci associated with epithelial ovarian cancer (EOC) susceptibility, but further progress requires integration of epidemiology and biology to illuminate true risk loci below genome ... Full text Link to item Cite

A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer.

Journal Article Int J Cancer · December 15, 2016 Menopausal estrogen-alone therapy (ET) is a well-established risk factor for serous and endometrioid ovarian cancer. Genetics also plays a role in ovarian cancer, which is partly attributable to 18 confirmed ovarian cancer susceptibility loci identified by ... Full text Link to item Cite

Telomere structure and maintenance gene variants and risk of five cancer types.

Journal Article Int J Cancer · December 15, 2016 Telomeres cap chromosome ends, protecting them from degradation, double-strand breaks, and end-to-end fusions. Telomeres are maintained by telomerase, a reverse transcriptase encoded by TERT, and an RNA template encoded by TERC. Loci in the TERT and adjoin ... Full text Link to item Cite

PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.

Journal Article J Med Genet · December 2016 BACKGROUND: The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some of these mutations are associated with breast cancer risk ... Full text Link to item Cite

Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility: results from a large-scale collaboration.

Journal Article Oncotarget · November 8, 2016 RNA editing in mammals is a form of post-transcriptional modification in which adenosine is converted to inosine by the adenosine deaminases acting on RNA (ADAR) family of enzymes. Based on evidence of altered ADAR expression in epithelial ovarian cancers ... Full text Link to item Cite

Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.

Journal Article Oncotarget · October 25, 2016 BACKGROUND: Regulatory T (Treg) cells, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and, thus, variants in genes encoding Treg cell immune molecules could be associated with ovarian cancer. METHODS: In a population of 15,59 ... Full text Link to item Cite

Dairy, calcium, vitamin D and ovarian cancer risk in African-American women.

Journal Article Br J Cancer · October 25, 2016 BACKGROUND: No previous study has evaluated the associations of dairy products, lactose, calcium and vitamin D with the risk of ovarian cancer in African-American women, who are known to have high mortality from the disease, as well as to be at risk for ca ... Full text Link to item Cite

Risk Prediction for Epithelial Ovarian Cancer in 11 United States-Based Case-Control Studies: Incorporation of Epidemiologic Risk Factors and 17 Confirmed Genetic Loci.

Journal Article Am J Epidemiol · October 15, 2016 Previously developed models for predicting absolute risk of invasive epithelial ovarian cancer have included a limited number of risk factors and have had low discriminatory power (area under the receiver operating characteristic curve (AUC) < 0.60). Becau ... Full text Open Access Link to item Cite

Association between Body Powder Use and Ovarian Cancer: The African American Cancer Epidemiology Study (AACES).

Journal Article Cancer Epidemiol Biomarkers Prev · October 2016 BACKGROUND: Epidemiologic studies indicate increased ovarian cancer risk among women who use genital powder, but this has not been thoroughly investigated in African American (AA) women, a group with a high prevalence of use. We evaluate the relationship b ... Full text Link to item Cite

Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study.

Journal Article Int J Epidemiol · October 2016 BACKGROUND: In vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention. However, the relationship between vitamin D and ovarian cancer is uncertain, with observational studies generating conflicting findi ... Full text Link to item Cite

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.

Journal Article Nat Commun · September 7, 2016 A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associat ... Full text Link to item Cite

Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

Journal Article Cancer Res · September 1, 2016 Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the G ... Full text Link to item Cite

Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types.

Journal Article Cancer Discov · September 2016 UNLABELLED: Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis dat ... Full text Link to item Cite

Reproductive factors and ovarian cancer risk in African-American women.

Journal Article Annals of epidemiology · September 2016 PurposeReproductive characteristics, the most established ovarian cancer risk factors, differ markedly between African-American and white women. Studies in predominantly white populations suggest that associations between reproductive characterist ... Full text Cite

Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses.

Journal Article PLoS Med · September 2016 BACKGROUND: Observational studies examining associations between adult height and risk of colorectal, prostate, and lung cancers have generated mixed results. We conducted meta-analyses using data from prospective cohort studies and further carried out Men ... Full text Link to item Cite

Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk.

Journal Article Hum Mol Genet · August 15, 2016 Rare and low frequency variants are not well covered in most germline genotyping arrays and are understudied in relation to epithelial ovarian cancer (EOC) risk. To address this gap, we used genotyping arrays targeting rarer protein-coding variation in 8,1 ... Full text Link to item Cite

Socioeconomic Status in Relation to the Risk of Ovarian Cancer in African-American Women: A Population-Based Case-Control Study.

Journal Article Am J Epidemiol · August 15, 2016 We investigated the association between socioeconomic status and ovarian cancer in African-American women. We used a population-based case-control study design that included case patients with incident ovarian cancer (n = 513) and age- and area-matched con ... Full text Link to item Cite

Obesity, weight gain, and ovarian cancer risk in African American women.

Journal Article Int J Cancer · August 1, 2016 Although there is growing evidence that higher adiposity increases ovarian cancer risk, little is known about its impact in African American (AA) women, the racial/ethnic group with the highest prevalence of obesity. We evaluated the impact of body mass in ... Full text Link to item Cite

Association between menopausal estrogen-only therapy and ovarian carcinoma risk

Journal Article Obstetrical and Gynecological Survey · August 1, 2016 Full text Cite

Assessing the genetic architecture of epithelial ovarian cancer histological subtypes.

Journal Article Hum Genet · July 2016 Epithelial ovarian cancer (EOC) is one of the deadliest common cancers. The five most common types of disease are high-grade and low-grade serous, endometrioid, mucinous and clear cell carcinoma. Each of these subtypes present distinct molecular pathogenes ... Full text Link to item Cite

Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · July 2016 BACKGROUND: Despite a large body of literature evaluating the association between recreational physical activity and epithelial ovarian cancer (EOC) risk, the extant evidence is inconclusive, and little is known about the independent association between re ... Full text Link to item Cite

Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium.

Journal Article Br J Cancer · June 28, 2016 BACKGROUND: Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between ... Full text Link to item Cite

The Association Between Body Mass Index and Presenting Symptoms in African American Women with Ovarian Cancer.

Journal Article J Womens Health (Larchmt) · June 2016 BACKGROUND: Ovarian cancer, the most lethal gynecologic malignancy, typically comes to clinical attention due to nonspecific gastrointestinal or pelvic symptoms. African Americans with ovarian cancer have a greater mortality burden than whites and are also ... Full text Link to item Cite

Recreational physical activity and ovarian cancer risk in African American women.

Journal Article Cancer Med · June 2016 The literature on recreational physical activity (RPA) and ovarian cancer risk is inconclusive and most studies of RPA and ovarian cancer have been conducted in white populations. This study is the first to investigate the association between RPA and ovari ... Full text Link to item Cite

History of chickenpox in glioma risk: a report from the glioma international case-control study (GICC).

Journal Article Cancer Med · June 2016 Varicella zoster virus (VZV) is a neurotropic α-herpesvirus that causes chickenpox and establishes life-long latency in the cranial nerve and dorsal root ganglia of the host. To date, VZV is the only virus consistently reported to have an inverse associati ... Full text Link to item Cite

Adult body mass index and risk of ovarian cancer by subtype: a Mendelian randomization study.

Journal Article Int J Epidemiol · June 2016 BACKGROUND: Observational studies have reported a positive association between body mass index (BMI) and ovarian cancer risk. However, questions remain as to whether this represents a causal effect, or holds for all histological subtypes. The lack of assoc ... Full text Link to item Cite

Mendelian randomization study of adiposity-related traits and risk of breast, ovarian, prostate, lung and colorectal cancer.

Journal Article Int J Epidemiol · June 2016 BACKGROUND: Adiposity traits have been associated with risk of many cancers in observational studies, but whether these associations are causal is unclear. Mendelian randomization (MR) uses genetic predictors of risk factors as instrumental variables to el ... Full text Link to item Cite

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.

Journal Article Gynecol Oncol · May 2016 OBJECTIVE: Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3' UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. ... Full text Link to item Cite

Assessment of Multifactor Gene-Environment Interactions and Ovarian Cancer Risk: Candidate Genes, Obesity, and Hormone-Related Risk Factors.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2016 BACKGROUND: Many epithelial ovarian cancer (EOC) risk factors relate to hormone exposure and elevated estrogen levels are associated with obesity in postmenopausal women. Therefore, we hypothesized that gene-environment interactions related to hormone-rela ... Full text Link to item Cite

Association Between Menopausal Estrogen-Only Therapy and Ovarian Carcinoma Risk.

Journal Article Obstet Gynecol · May 2016 OBJECTIVE: To describe the association between postmenopausal estrogen-only therapy use and risk of ovarian carcinoma, specifically with regard to disease histotype and duration and timing of use. METHODS: We conducted a pooled analysis of 906 women with o ... Full text Link to item Cite

The association between socioeconomic status and tumour stage at diagnosis of ovarian cancer: A pooled analysis of 18 case-control studies.

Journal Article Cancer Epidemiol · April 2016 PURPOSE: Socioeconomic status (SES) is a known predictor of survival for several cancers and it has been suggested that SES differences affecting tumour stage at diagnosis may be the most important explanatory factor for this. However, only a limited numbe ... Full text Link to item Cite

Analgesic medication use and risk of epithelial ovarian cancer in African American women.

Journal Article Br J Cancer · March 29, 2016 BACKGROUND: Existing literature examining analgesic medication use and epithelial ovarian cancer (EOC) risk has been inconsistent, with the majority of studies reporting an inverse association. Race-specific effects of this relationship have not been adequ ... Full text Link to item Cite

Investigation of Exomic Variants Associated with Overall Survival in Ovarian Cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2016 BACKGROUND: While numerous susceptibility loci for epithelial ovarian cancer (EOC) have been identified, few associations have been reported with overall survival. In the absence of common prognostic genetic markers, we hypothesize that rare coding variant ... Full text Link to item Cite

Dietary carbohydrate intake, glycaemic load, glycaemic index and ovarian cancer risk in African-American women.

Journal Article Br J Nutr · February 28, 2016 Epidemiological evidence regarding the association between carbohydrate intake, glycaemic load (GL) and glycaemic index (GI) and risk of ovarian cancer has been mixed. Little is known about their impact on ovarian cancer risk in African-American women. Ass ... Full text Link to item Cite

A targeted genetic association study of epithelial ovarian cancer susceptibility.

Journal Article Oncotarget · February 16, 2016 BACKGROUND: Genome-wide association studies have identified several common susceptibility alleles for epithelial ovarian cancer (EOC). To further understand EOC susceptibility, we examined previously ungenotyped candidate variants, including uncommon varia ... Full text Link to item Cite

Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer.

Journal Article Oncotarget · February 9, 2016 Women with epithelial ovarian cancer (EOC) are usually treated with platinum/taxane therapy after cytoreductive surgery but there is considerable inter-individual variation in response. To identify germline single-nucleotide polymorphisms (SNPs) that contr ... Full text Link to item Cite

Approaching a Scientific Consensus on the Association between Allergies and Glioma Risk: A Report from the Glioma International Case-Control Study.

Journal Article Cancer Epidemiol Biomarkers Prev · February 2016 BACKGROUND: Several previous studies have found inverse associations between glioma susceptibility and a history of allergies or other atopic conditions. Some evidence indicates that respiratory allergies are likely to be particularly relevant with regard ... Full text Link to item Cite

BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers.

Other J Natl Cancer Inst · February 2016 BACKGROUND: The K3326X variant in BRCA2 (BRCA2*c.9976A>T; p.Lys3326*; rs11571833) has been found to be associated with small increased risks of breast cancer. However, it is not clear to what extent linkage disequilibrium with fully pathogenic mutations mi ... Full text Link to item Cite

The Glioma International Case-Control Study: A Report From the Genetic Epidemiology of Glioma International Consortium.

Journal Article Am J Epidemiol · January 15, 2016 Decades of research have established only a few etiological factors for glioma, which is a rare and highly fatal brain cancer. Common methodological challenges among glioma studies include small sample sizes, heterogeneity of tumor subtypes, and retrospect ... Full text Link to item Cite

Evidence of a genetic link between endometriosis and ovarian cancer.

Journal Article Fertil Steril · January 2016 OBJECTIVE: To evaluate whether endometriosis-associated genetic variation affects risk of ovarian cancer. DESIGN: Pooled genetic analysis. SETTING: University hospital. PATIENT(S): Genetic data from 46,176 participants (15,361 ovarian cancer cases and 30,8 ... Full text Link to item Cite

A Cross-Cancer Genetic Association Analysis of the DNA Repair and DNA Damage Signaling Pathways for Lung, Ovary, Prostate, Breast, and Colorectal Cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · January 2016 BACKGROUND: DNA damage is an established mediator of carcinogenesis, although genome-wide association studies (GWAS) have identified few significant loci. This cross-cancer site, pooled analysis was performed to increase the power to detect common variants ... Full text Link to item Cite

DNA Methylation of Regulatory Regions of Imprinted Genes at Birth and Its Relation to Infant Temperament.

Journal Article Genet Epigenet · 2016 BACKGROUND: DNA methylation of the differentially methylated regions (DMRs) of imprinted genes is relevant to neurodevelopment. METHODS: DNA methylation status of the DMRs of nine imprinted genes in umbilical cord blood leukocytes was analyzed in relation ... Full text Link to item Cite

A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients.

Journal Article BMC Cancer · December 16, 2015 BACKGROUND: Personalized therapy considering clinical and genetic patient characteristics will further improve breast cancer survival. Two widely used treatments, chemotherapy and radiotherapy, can induce oxidative DNA damage and, if not repaired, cell dea ... Full text Link to item Cite

Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium.

Journal Article Clin Cancer Res · December 1, 2015 PURPOSE: Chemotherapy resistance remains a major challenge in the treatment of ovarian cancer. We hypothesize that germline polymorphisms might be associated with clinical outcome. EXPERIMENTAL DESIGN: We analyzed approximately 2.8 million genotyped and im ... Full text Link to item Cite

Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk.

Journal Article Genet Epidemiol · December 2015 Epithelial-mesenchymal transition (EMT) is a process whereby epithelial cells assume mesenchymal characteristics to facilitate cancer metastasis. However, EMT also contributes to the initiation and development of primary tumors. Prior studies that explored ... Full text Link to item Cite

Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer.

Journal Article Carcinogenesis · November 2015 Genome-wide association studies have identified 20 genomic regions associated with risk of epithelial ovarian cancer (EOC), but many additional risk variants may exist. Here, we evaluated associations between common genetic variants [single nucleotide poly ... Full text Link to item Cite

Cross Cancer Genomic Investigation of Inflammation Pathway for Five Common Cancers: Lung, Ovary, Prostate, Breast, and Colorectal Cancer.

Journal Article J Natl Cancer Inst · November 2015 BACKGROUND: Inflammation has been hypothesized to increase the risk of cancer development as an initiator or promoter, yet no large-scale study of inherited variation across cancer sites has been conducted. METHODS: We conducted a cross-cancer genomic anal ... Full text Link to item Cite

A functional variant in HOXA11-AS, a novel long non-coding RNA, inhibits the oncogenic phenotype of epithelial ovarian cancer.

Journal Article Oncotarget · October 27, 2015 The homeobox A (HOXA) region of protein-coding genes impacts female reproductive system embryogenesis and ovarian carcinogenesis. The 5-prime end of HOXA includes three long non-coding RNAs (lncRNAs) (HOXA10-AS, HOXA11-AS, and HOTTIP) that are underexplore ... Full text Link to item Cite

Shared genetics underlying epidemiological association between endometriosis and ovarian cancer.

Journal Article Hum Mol Genet · October 15, 2015 Epidemiological studies have demonstrated associations between endometriosis and certain histotypes of ovarian cancer, including clear cell, low-grade serous and endometrioid carcinomas. We aimed to determine whether the observed associations might be due ... Full text Link to item Cite

Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk.

Journal Article Cancer Epidemiol Biomarkers Prev · October 2015 BACKGROUND: Genome-wide association studies (GWAS) have so far reported 12 loci associated with serous epithelial ovarian cancer (EOC) risk. We hypothesized that some of these loci function through nearby transcription factor (TF) genes and that putative t ... Full text Link to item Cite

Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer.

Journal Article Nat Commun · September 22, 2015 Genome-wide association studies have reported 11 regions conferring risk of high-grade serous epithelial ovarian cancer (HGSOC). Expression quantitative trait locus (eQTL) analyses can identify candidate susceptibility genes at risk loci. Here we evaluate ... Full text Link to item Cite

Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium.

Journal Article Br J Cancer · September 1, 2015 BACKGROUND: Observational studies have reported a modest association between obesity and risk of ovarian cancer; however, whether it is also associated with survival and whether this association varies for the different histologic subtypes are not clear. W ... Full text Link to item Cite

Genome-wide significant risk associations for mucinous ovarian carcinoma.

Journal Article Nat Genet · August 2015 Genome-wide association studies have identified several risk associations for ovarian carcinomas but not for mucinous ovarian carcinomas (MOCs). Our analysis of 1,644 MOC cases and 21,693 controls with imputation identified 3 new risk associations: rs75259 ... Full text Link to item Cite

Maternal cadmium, iron and zinc levels, DNA methylation and birth weight.

Journal Article BMC Pharmacol Toxicol · July 15, 2015 BACKGROUND: Cadmium (Cd) is a ubiquitous and environmentally persistent toxic metal that has been implicated in neurotoxicity, carcinogenesis and obesity and essential metals including zinc (Zn) and iron (Fe) may alter these outcomes. However mechanisms un ... Full text Link to item Cite

Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci.

Journal Article Hum Mol Genet · July 1, 2015 Understanding the regulatory landscape of the human genome is a central question in complex trait genetics. Most single-nucleotide polymorphisms (SNPs) associated with cancer risk lie in non-protein-coding regions, implicating regulatory DNA elements as fu ... Full text Link to item Cite

Newborns of obese parents have altered DNA methylation patterns at imprinted genes

Journal Article International Journal of Obesity · April 9, 2015 Background:Several epidemiologic studies have demonstrated associations between periconceptional environmental exposures and health status of the offspring in later life. Although these environmentally related effects have been attributed to epigenetic cha ... Full text Open Access Cite

Population distribution of lifetime risk of ovarian cancer in the United States.

Journal Article Cancer Epidemiol Biomarkers Prev · April 2015 BACKGROUND: In U.S. women, lifetime risk of ovarian cancer is 1.37%, but some women are at a substantially lower or higher risk than this average. METHODS: We have characterized the distribution of lifetime risk in the general population. Published data on ... Full text Link to item Cite

Newborns of obese parents have altered DNA methylation patterns at imprinted genes.

Journal Article Int J Obes (Lond) · April 2015 BACKGROUND: Several epidemiologic studies have demonstrated associations between periconceptional environmental exposures and health status of the offspring in later life. Although these environmentally related effects have been attributed to epigenetic ch ... Full text Open Access Link to item Cite

Evaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study.

Journal Article Gynecol Oncol · March 2015 OBJECTIVE: Ovarian cancer is a hormone-related disease with a strong genetic basis. However, none of its high-penetrance susceptibility genes and GWAS-identified variants to date are known to be involved in hormonal pathways. Given the hypothesized etiolog ... Full text Link to item Cite

Targeted sequencing in chromosome 17q linkage region identifies familial glioma candidates in the Gliogene Consortium.

Journal Article Sci Rep · February 5, 2015 Glioma is a rare, but highly fatal, cancer that accounts for the majority of malignant primary brain tumors. Inherited predisposition to glioma has been consistently observed within non-syndromic families. Our previous studies, which involved non-parametri ... Full text Link to item Cite

Identification of six new susceptibility loci for invasive epithelial ovarian cancer.

Journal Article Nat Genet · February 2015 Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and BRCA2 mutation carriers who are at high risk of EOC. After imputation to 1 ... Full text Link to item Cite

Germline mutations in shelterin complex genes are associated with familial glioma.

Journal Article J Natl Cancer Inst · January 2015 Gliomas are the most common brain tumor, with several histological subtypes of various malignancy grade. The genetic contribution to familial glioma is not well understood. Using whole exome sequencing of 90 individuals from 55 families, we identified two ... Full text Link to item Cite

Survival and low-grade glioma: the emergence of genetic information.

Journal Article Neurosurg Focus · January 2015 Significant gaps exist in our understanding of the causes and clinical management of glioma. One of the biggest gaps is how best to manage low-grade (World Health Organization [WHO] Grade II) glioma. Low-grade glioma (LGG) is a uniformly fatal disease of y ... Full text Link to item Cite

Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk.

Journal Article PLoS One · 2015 BACKGROUND: Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which in turn may promote the formation of reactive oxygen species, promoting DNA damage and aberrant ex ... Full text Link to item Cite

Survival in women with ovarian cancer with and without microsatellite instability.

Journal Article Eur J Gynaecol Oncol · 2015 PURPOSE OF INVESTIGATION: Microsatellite instability (MSI) is a hallmark of defective mismatch repair and is present in approximately 20% of ovarian cancers. It is not known if the presence of MSI predicts survival in women with epithelial ovarian cancer. ... Link to item Cite

Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk.

Journal Article Mol Nutr Food Res · October 2014 SCOPE: We reevaluated previously reported associations between variants in pathways of one-carbon (1-C) (folate) transfer genes and ovarian carcinoma (OC) risk, and in related pathways of purine and pyrimidine metabolism, and assessed interactions with fol ... Full text Link to item Cite

Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer.

Journal Article Neuro Oncol · October 2014 BACKGROUND: Although familial susceptibility to glioma is known, the genetic basis for this susceptibility remains unidentified in the majority of glioma-specific families. An alternative approach to identifying such genes is to examine cancer pedigrees, w ... Full text Link to item Cite

A multi-center population-based case-control study of ovarian cancer in African-American women: the African American Cancer Epidemiology Study (AACES).

Journal Article BMC Cancer · September 22, 2014 BACKGROUND: Ovarian cancer (OVCA) is the leading cause of death from gynecological cancer, with poorer survival for African American (AA) women compared to whites. However, little is known about risk factors for OVCA in AA. To study the epidemiology of OVC ... Full text Link to item Cite

A review of the application of inflammatory biomarkers in epidemiologic cancer research.

Journal Article Cancer Epidemiol Biomarkers Prev · September 2014 Inflammation is a facilitating process for multiple cancer types. It is believed to affect cancer development and progression through several etiologic pathways, including increased levels of DNA adduct formation, increased angiogenesis, and altered antiap ... Full text Link to item Cite

Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort.

Journal Article Epigenetics · August 2014 Epigenetic mechanisms are proposed to link maternal concentrations of methyl group donor nutrients with the risk of low birth weight. However, empirical data are lacking. We have examined the association between maternal folate and birth weight and assesse ... Full text Open Access Link to item Cite

Variation in NF-κB signaling pathways and survival in invasive epithelial ovarian cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · July 2014 Survival in epithelial ovarian cancer (EOC) is influenced by the host immune response, yet the key genetic determinants of inflammation and immunity that affect prognosis are not known. The nuclear factor-κB (NF-κB) transcription factor family plays an imp ... Full text Link to item Cite

ABCA transporter gene expression and poor outcome in epithelial ovarian cancer.

Journal Article J Natl Cancer Inst · July 2014 BACKGROUND: ATP-binding cassette (ABC) transporters play various roles in cancer biology and drug resistance, but their association with outcomes in serous epithelial ovarian cancer (EOC) is unknown. METHODS: The relationship between clinical outcomes and ... Full text Link to item Cite

Risk factors for ovarian cancers with and without microsatellite instability.

Journal Article Int J Gynecol Cancer · May 2014 OBJECTIVE: In a population-based sample of epithelial ovarian cancers, the objective of this study was to evaluate the association between microsatellite instability (MSI) status and the following factors: (1) ovarian cancer risk factors and (2) the distri ... Full text Link to item Cite

Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA.

Journal Article Hum Genet · May 2014 Epithelial ovarian cancer (EOC) is a heterogeneous cancer with both genetic and environmental risk factors. Variants influencing the risk of developing the less-common EOC subtypes have not been fully investigated. We performed a genome-wide association st ... Full text Link to item Cite

Endogenous and exogenous hormone exposure and the risk of meningioma in men.

Journal Article J Neurosurg · April 2014 OBJECT: Meningioma is a disease with considerable morbidity and is more commonly diagnosed in females than in males. Hormonally related risk factors have long been postulated to be associated with meningioma risk, but no examination of these factors has be ... Full text Link to item Cite

Large-scale evaluation of common variation in regulatory T cell-related genes and ovarian cancer outcome.

Journal Article Cancer Immunol Res · April 2014 The presence of regulatory T cells (Treg) in solid tumors is known to play a role in patient survival in ovarian cancer and other malignancies. We assessed inherited genetic variations via 749 tag single-nucleotide polymorphisms (SNP) in 25 Treg-associated ... Full text Link to item Cite

Association between IHC and MSI testing to identify mismatch repair-deficient patients with ovarian cancer.

Journal Article Genet Test Mol Biomarkers · April 2014 OBJECTIVE: In epithelial ovarian cancer, concordance between results of microsatellite instability (MSI) and immunohistochemical (IHC) testing has not been demonstrated. This study evaluated the association of MSI-high (MSI-H) status with loss of expressio ... Full text Link to item Cite

Risk of ovarian cancer and the NF-κB pathway: genetic association with IL1A and TNFSF10.

Journal Article Cancer Res · February 1, 2014 A missense single-nucleotide polymorphism (SNP) in the immune modulatory gene IL1A has been associated with ovarian cancer risk (rs17561). Although the exact mechanism through which this SNP alters risk of ovarian cancer is not clearly understood, rs17561 ... Full text Link to item Cite

Aspirin, nonaspirin nonsteroidal anti-inflammatory drug, and acetaminophen use and risk of invasive epithelial ovarian cancer: a pooled analysis in the Ovarian Cancer Association Consortium.

Journal Article J Natl Cancer Inst · February 2014 BACKGROUND: Regular aspirin use is associated with reduced risk of several malignancies. Epidemiologic studies analyzing aspirin, nonaspirin nonsteroidal anti-inflammatory drug (NSAID), and acetaminophen use and ovarian cancer risk have been inconclusive. ... Full text Link to item Cite

Maternal stress, preterm birth, and DNA methylation at imprint regulatory sequences in humans.

Journal Article Genet Epigenet · 2014 In infants exposed to maternal stress in utero, phenotypic plasticity through epigenetic events may mechanistically explain increased risk of preterm birth (PTB), which confers increased risk for neurodevelopmental disorders, cardiovascular disease, and ca ... Full text Open Access Link to item Cite

Kernel canonical correlation analysis for assessing gene-gene interactions and application to ovarian cancer.

Journal Article Eur J Hum Genet · January 2014 Although single-locus approaches have been widely applied to identify disease-associated single-nucleotide polymorphisms (SNPs), complex diseases are thought to be the product of multiple interactions between loci. This has led to the recent development of ... Full text Link to item Cite

A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk.

Journal Article Hum Mol Genet · December 15, 2013 Mean telomere length (TL) in blood cells is heritable and has been reported to be associated with risks of several diseases, including cancer. We conducted a meta-analysis of three GWAS for TL (total n=2240) and selected 1629 variants for replication via t ... Full text Link to item Cite

Novel associations of UDP-glucuronosyltransferase 2B gene variants with prostate cancer risk in a multiethnic study.

Journal Article BMC Cancer · November 22, 2013 BACKGROUND: We have previously shown that a functional polymorphism of the UGT2B15 gene (rs1902023) was associated with increased risk of prostate cancer (PC). Novel functional polymorphisms of the UGT2B17 and UGT2B15 genes have been recently characterized ... Full text Open Access Link to item Cite

Molecular signatures of epithelial ovarian cancer: analysis of associations with tumor characteristics and epidemiologic risk factors.

Journal Article Cancer Epidemiol Biomarkers Prev · October 2013 BACKGROUND: Six gene expression subtypes of invasive epithelial ovarian cancer were recently defined using microarrays by Tothill and colleagues. The Cancer Genome Atlas (TCGA) project subsequently replicated these subtypes and identified a signature predi ... Full text Link to item Cite

Ovarian Cancer

Journal Article · August 29, 2013 Full text Cite

Genital powder use and risk of ovarian cancer: a pooled analysis of 8,525 cases and 9,859 controls.

Journal Article Cancer Prev Res (Phila) · August 2013 Genital powder use has been associated with risk of epithelial ovarian cancer in some, but not all, epidemiologic investigations, possibly reflecting the carcinogenic effects of talc particles found in most of these products. Whether risk increases with nu ... Full text Link to item Cite

Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring.

Journal Article Int J Obes (Lond) · July 2013 OBJECTIVES: Low birth weight (LBW) has been associated with common adult-onset chronic diseases, including obesity, cardiovascular disease, type II diabetes and some cancers. The etiology of LBW is multi-factorial. However, recent evidence suggests exposur ... Full text Open Access Link to item Cite

Risk factors for ovarian cancers with and without microsatellite instability.

Journal Article Int J Gynecol Cancer · July 2013 OBJECTIVE: The objective of this study was to evaluate the association between microsatellite instability (MSI) status and (1) ovarian cancer risk factors and (2) the distribution of the specific histologic subtypes in a population-based sample of epitheli ... Full text Link to item Cite

Cigarette smoking and risk of ovarian cancer: a pooled analysis of 21 case-control studies.

Journal Article Cancer Causes Control · May 2013 PURPOSE: The majority of previous studies have observed an increased risk of mucinous ovarian tumors associated with cigarette smoking, but the association with other histological types is unclear. In a large pooled analysis, we examined the risk of epithe ... Full text Link to item Cite

Analysis of over 10,000 Cases finds no association between previously reported candidate polymorphisms and ovarian cancer outcome.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2013 BACKGROUND: Ovarian cancer is a leading cause of cancer-related death among women. In an effort to understand contributors to disease outcome, we evaluated single-nucleotide polymorphisms (SNP) previously associated with ovarian cancer recurrence or surviv ... Full text Link to item Cite

Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2013 BACKGROUND: There are several well-established environmental risk factors for ovarian cancer, and recent genome-wide association studies have also identified six variants that influence disease risk. However, the interplay between such risk factors and sus ... Full text Link to item Cite

Validation of ovarian cancer gene expression signatures for survival and subtype in formalin fixed paraffin embedded tissues.

Journal Article Gynecol Oncol · April 2013 INTRODUCTION: Gene expression signatures have been identified for epithelial ovarian cancer survival (TCGA) and intrinsic subtypes (Tothill et al.). One obstacle to clinical translation is that these signatures were developed using frozen tissue, whereas u ... Full text Link to item Cite

Vitamin D receptor (VDR) polymorphisms and risk of ovarian cancer in Caucasian and African American women.

Journal Article Gynecol Oncol · April 2013 OBJECTIVE: Polymorphisms in the vitamin D receptor (VDR) gene have been shown in some studies to be associated with the risk of epithelial ovarian cancer (EOC) in Caucasian women. There are no published reports among African Americans. METHODS: Case-contro ... Full text Link to item Cite

Global ovarian cancer health disparities.

Journal Article Gynecol Oncol · April 2013 OBJECTIVE: The objective of this article is to broadly review the scientific literature and summarize the most up-to-date findings on ovarian cancer health disparities worldwide and in the United States (U.S.). METHODS: The present literature on disparitie ... Full text Link to item Cite

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.

Journal Article Nat Genet · April 2013 TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ∼480 SNPs at the TERT locus in breast (n = 103,991), ovarian (n = 39,774) and BRCA1 muta ... Full text Link to item Cite

GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.

Journal Article Nat Genet · April 2013 Genome-wide association studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC), with another two suggestive loci reaching near genome-wide significance. We pooled data from a GWAS conducted in North America with another ... Full text Link to item Cite

Obesity and risk of ovarian cancer subtypes: evidence from the Ovarian Cancer Association Consortium.

Journal Article Endocr Relat Cancer · April 2013 Whilst previous studies have reported that higher BMI increases a woman's risk of developing ovarian cancer, associations for the different histological subtypes have not been well defined. As the prevalence of obesity has increased dramatically, and class ... Full text Link to item Cite

Tubal ligation and risk of ovarian cancer subtypes: a pooled analysis of case-control studies.

Journal Article Int J Epidemiol · April 2013 BACKGROUND: Tubal ligation is a protective factor for ovarian cancer, but it is unknown whether this protection extends to all invasive histological subtypes or borderline tumors. We undertook an international collaborative study to examine the association ... Full text Link to item Cite

Description of selected characteristics of familial glioma patients - results from the Gliogene Consortium.

Journal Article Eur J Cancer · April 2013 BACKGROUND: While certain inherited syndromes (e.g. Neurofibromatosis or Li-Fraumeni) are associated with an increased risk of glioma, most familial gliomas are non-syndromic. This study describes the demographic and clinical characteristics of the largest ... Full text Link to item Cite

Exogenous hormone use, reproductive factors, and risk of intracranial meningioma in females.

Journal Article J Neurosurg · March 2013 OBJECT: The 2-fold higher incidence of meningioma in women compared with men has long suggested a role for hormonally mediated risk factors, but specific mechanisms remain elusive. METHODS: The study included data obtained in 1127 women 29-79 years of age ... Full text Link to item Cite

Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort.

Journal Article BMC Med · February 6, 2013 BACKGROUND: Data from epidemiological and animal model studies suggest that nutrition during pregnancy may affect the health status of subsequent generations. These transgenerational effects are now being explained by disruptions at the level of the epigen ... Full text Open Access Link to item Cite

Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium.

Journal Article BMC Cancer · January 22, 2013 BACKGROUND: Studies evaluating the association between alcohol intake and ovarian carcinoma (OC) are inconsistent. Because OC and ovarian borderline tumor histologic types differ genetically, molecularly and clinically, large numbers are needed to estimate ... Full text Link to item Cite

Associations between birth and one year anthropometric measurements and IGF2 and IGF2R genetic variants in African American and Caucasian American infants.

Journal Article J Pediatr Genet · 2013 Insulin-like growth factor 2 receptor (IGF2R) and insulin-like growth factor 2 (IGF2) genetic variants have been inconsistently associated with low birth weight and birth length in Caucasian and Asian infants, however few studies have included African Amer ... Full text Open Access Link to item Cite

Association of uridine diphosphate-glucuronosyltransferase 2B gene variants with serum glucuronide levels and prostate cancer risk.

Journal Article Genet Test Mol Biomarkers · January 2013 AIMS: Uridine diphosphate-glucuronosyltransferase 2B (UGT2B) enzymes conjugate testosterone metabolites to enable their excretion in humans. The functional significance of the UGT2B genetic variants has never been described in humans. We evaluated UGT2B va ... Full text Link to item Cite

Inherited variants in regulatory T cell genes and outcome of ovarian cancer.

Journal Article PLoS One · 2013 Although ovarian cancer is the most lethal of gynecologic malignancies, wide variation in outcome following conventional therapy continues to exist. The presence of tumor-infiltrating regulatory T cells (Tregs) has a role in outcome of this disease, and a ... Full text Link to item Cite

Assessment of autoantibodies to meningioma in a population-based study.

Journal Article Am J Epidemiol · January 1, 2013 Meningioma is an intracranial tumor with few confirmed risk factors. Recent research points to an impact on meningioma risk from factors related to immune function and development, such as allergy, immunoglobulin E, and Varicella infection status. To furth ... Full text Link to item Cite

Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer.

Journal Article Nat Commun · 2013 HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with epithelial ovarian cancer risk ac ... Full text Link to item Cite

Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31.

Journal Article Nat Commun · 2013 Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized that variants in the 3' untranslated region at putative mi ... Full text Link to item Cite

Maternal BMI, IGF-I Levels, and Birth Weight in African American and White Infants.

Journal Article Int J Pediatr · 2013 At birth, elevated IGF-I levels have been linked to birth weight extremes; high birth weight and low birth weight are risk factors for adult-onset chronic diseases including obesity, cardiovascular disease, and type 2 diabetes. We examined associations bet ... Full text Open Access Link to item Cite

Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring

Journal Article International Journal of Obesity · 2013 Objectives: Low birth weight (LBW) has been associated with common adult-onset chronic diseases, including obesity, cardiovascular disease, type II diabetes and some cancers. The etiology of LBW is multi-factorial. However, recent evidence suggests exposur ... Full text Open Access Cite

A variable age of onset segregation model for linkage analysis, with correction for ascertainment, applied to glioma.

Journal Article Cancer Epidemiol Biomarkers Prev · December 2012 BACKGROUND: We propose a 2-step model-based approach, with correction for ascertainment, to linkage analysis of a binary trait with variable age of onset and apply it to a set of multiplex pedigrees segregating for adult glioma. METHODS: First, we fit segr ... Full text Link to item Cite

Frequency of mutations in mismatch repair genes in a population-based study of women with ovarian cancer.

Journal Article Br J Cancer · November 6, 2012 BACKGROUND: Mutations in genes for hereditary non-polyposis colorectal cancer (HNPCC) in ovarian cancer patients remains poorly defined. We sought to estimate the frequency and characteristics of HNPCC gene mutations in a population-based sample of women w ... Full text Link to item Cite

ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium.

Journal Article Cancer Causes Control · November 2012 PURPOSE: Previous studies have examined the association between ABO blood group and ovarian cancer risk, with inconclusive results. METHODS: In eight studies participating in the Ovarian Cancer Association Consortium, we determined ABO blood groups and dip ... Full text Link to item Cite

Uncertainty in the utility of immunohistochemistry in mismatch repair protein expression in epithelial ovarian cancer.

Journal Article Anticancer Res · November 2012 BACKGROUND: Utility of immunohistochemistry (IHC) for mismatch repair (MMR) protein expression has been demonstrated in colorectal cancer but remains incompletely defined in ovarian cancer. We evaluated MMR protein expression in three population-based samp ... Link to item Cite

Dental x-rays and risk of meningioma.

Journal Article Cancer · September 15, 2012 BACKGROUND: Ionizing radiation is a consistently identified and potentially modifiable risk factor for meningioma, which is the most frequently reported primary brain tumor in the United States. The objective of this study was to examine the association be ... Full text Link to item Cite

Insight in glioma susceptibility through an analysis of 6p22.3, 12p13.33-12.1, 17q22-23.2 and 18q23 SNP genotypes in familial and non-familial glioma.

Journal Article Hum Genet · September 2012 The risk of glioma has consistently been shown to be increased twofold in relatives of patients with primary brain tumors (PBT). A recent genome-wide linkage study of glioma families provided evidence for a disease locus on 17q12-21.32, with the possibilit ... Full text Link to item Cite

Insulin-like growth factor 2/H19 methylation at birth and risk of overweight and obesity in children.

Journal Article J Pediatr · July 2012 OBJECTIVE: To determine whether aberrant DNA methylation at differentially methylated regions (DMRs) regulating insulin-like growth factor 2 (IGF2) expression in umbilical cord blood is associated with overweight or obesity in a multiethnic cohort. STUDY D ... Full text Open Access Link to item Cite

Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements.

Journal Article Epigenetics · July 2012 Depressed mood in pregnancy has been linked to low birth weight (LBW, < 2,500 g), a risk factor for adult-onset chronic diseases in offspring. We examined maternal depressed mood in relation to birth weight and evaluated the role of DNA methylation at regu ... Full text Open Access Link to item Cite

Cigarette smoking and risk of meningioma: the effect of gender.

Journal Article Cancer Epidemiol Biomarkers Prev · June 2012 BACKGROUND: A number of studies have reported on the association between smoking and meningioma risk, with inconsistent findings. We examined the effect of gender on the association between cigarette smoking and risk of intracranial meningioma in a large p ... Full text Link to item Cite

Breast and ovarian cancer risk and risk reduction in Jewish BRCA1/2 mutation carriers.

Journal Article J Clin Oncol · April 20, 2012 PURPOSE: Mutations in BRCA1/2 dramatically increase the risk of both breast and ovarian cancers. Three mutations in these genes (185delAG, 5382insC, and 6174delT) occur at high frequency in Ashkenazi Jews. We evaluated how these common Jewish mutations (CJ ... Full text Link to item Cite

Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight.

Journal Article Cancer Causes Control · April 2012 PURPOSE: Altered methylation at Insulin-like Growth Factor 2 (IGF2) regulatory regions has previously been associated with obesity, and several malignancies including colon, esophageal, and prostate adenocarcinomas, presumably via changes in expression and ... Full text Open Access Link to item Cite

Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies.

Journal Article Lancet Oncol · April 2012 BACKGROUND: Endometriosis is a risk factor for epithelial ovarian cancer; however, whether this risk extends to all invasive histological subtypes or borderline tumours is not clear. We undertook an international collaborative study to assess the associati ... Full text Link to item Cite

Common variation in Nemo-like kinase is associated with risk of ovarian cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2012 BACKGROUND: Overexpression of mitotic kinases has been associated with prognosis, histologic grade, and clinical stage in ovarian cancer, but the relationship between inherited variation in these genes and ovarian cancer risk has not been well defined. MET ... Full text Link to item Cite

Ovarian cancer risk associated with inherited inflammation-related variants.

Journal Article Cancer Res · March 1, 2012 The importance of inflammation pathways to the development of many human cancers prompted us to examine the associations between single-nucleotide polymorphisms (SNP) in inflammation-related genes and risk of ovarian cancer. In a multisite case-control stu ... Full text Link to item Cite

Gene set analysis of survival following ovarian cancer implicates macrolide binding and intracellular signaling genes.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2012 BACKGROUND: Genome-wide association studies (GWAS) for epithelial ovarian cancer (EOC), the most lethal gynecologic malignancy, have identified novel susceptibility loci. GWAS for survival after EOC have had more limited success. The association of each si ... Full text Link to item Cite

Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke.

Journal Article Gene · February 15, 2012 Epigenetic alterations may mechanistically explain the developmental origins of adult disease, namely the hypothesis that many complex adult chronic diseases originate as a result of conditions encountered in utero. If true, epigenetically regulated imprin ... Full text Link to item Cite

Loss of ARID1A-associated protein expression is a frequent event in clear cell and endometrioid ovarian cancers.

Journal Article Int J Gynecol Cancer · January 2012 BACKGROUND: Inactivating somatic mutations in the ARID1A gene are described in a significant fraction of clear cell and endometrioid ovarian cancers leading to loss of the corresponding protein (BAF250a). Expression of BAF250a was examined in clear cell an ... Full text Link to item Cite

IGF2R genetic variants, circulating IGF2 concentrations and colon cancer risk in African Americans and Whites.

Journal Article Dis Markers · 2012 The Mannose 6 Phosphate/Insulin-like Growth Factor Receptor-2 (IGF2R) encodes a type-1 membrane protein that modulates availability of the potent mitogen, IGF2. We evaluated the associations between IGF2R non-synonymous genetic variants (c.5002G>A, Gly1619 ... Full text Link to item Cite

European American stratification in ovarian cancer case control data: the utility of genome-wide data for inferring ancestry.

Journal Article PLoS One · 2012 We investigated the ability of several principal components analysis (PCA)-based strategies to detect and control for population stratification using data from a multi-center study of epithelial ovarian cancer among women of European-American ethnicity. Th ... Full text Link to item Cite

Regular Multivitamin Supplement Use, Single Nucleotide Polymorphisms in ATIC, SHMT2, and SLC46A1, and Risk of Ovarian Carcinoma.

Journal Article Front Genet · 2012 ATIC, SHMT2, and SLC46A1 have essential roles in one-carbon (1-C) transfer. The authors examined whether associations between ovarian carcinoma and 15 variants in these genes are modified by regular multivitamin use, a source of 1-C donors, among Caucasian ... Full text Link to item Cite

Germline copy number variation and ovarian cancer survival.

Journal Article Front Genet · 2012 Copy number variants (CNVs) have been implicated in many complex diseases. We examined whether inherited CNVs were associated with overall survival among women with invasive epithelial ovarian cancer. Germline DNA from 1,056 cases (494 deceased, average of ... Full text Link to item Cite

Genome-wide high-density SNP linkage search for glioma susceptibility loci: results from the Gliogene Consortium.

Journal Article Cancer Res · December 15, 2011 Gliomas, which generally have a poor prognosis, are the most common primary malignant brain tumors in adults. Recent genome-wide association studies have shown that inherited susceptibility plays a role in the development of glioma. Although first-degree r ... Full text Link to item Cite

Effect of hysterectomy with ovarian preservation on ovarian function.

Journal Article Obstet Gynecol · December 2011 OBJECTIVE: To prospectively estimate the risk for earlier ovarian failure among women undergoing hysterectomy with ovarian preservation, as compared with women of similar age without hysterectomy. METHODS: A prospective cohort study was conducted among wom ... Full text Link to item Cite

Family and personal medical history and risk of meningioma.

Journal Article J Neurosurg · December 2011 OBJECT: Little is known about the epidemiology of meningioma, the most frequently reported primary brain tumor in the US. The authors undertook a case-control study to examine the relationship between family and personal medical history and meningioma risk ... Full text Link to item Cite

Risk factors by molecular subtypes of breast cancer across a population-based study of women 56 years or younger.

Journal Article Breast Cancer Res Treat · November 2011 Differences in incidence, prognosis, and treatment response suggest gene expression patterns may discern breast cancer subtypes with unique risk factor profiles; however, previous results were based predominantly on older women. In this study, we examined ... Full text Link to item Cite

What can we learn from the age- and race/ethnicity- specific rates of inflammatory breast carcinoma?

Journal Article Breast Cancer Res Treat · November 2011 Inflammatory Breast Carcinoma (IBC), the most aggressive type of breast tumor with unique clinicopathological presentation, is hypothesized to have distinct etiology with a socioeconomic status (SES) component. Using the Surveillance, Epidemiology and End ... Full text Link to item Cite

The effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the IGF2 imprinted control regions in the offspring.

Journal Article Clin Epigenetics · October 26, 2011 In utero exposures to environmental factors may result in persistent epigenetic modifications affecting normal development and susceptibility to chronic diseases in later life. We explored the relationship between exposure of the growing fetus to maternal ... Full text Open Access Link to item Cite

Reduced allergy and immunoglobulin E among adults with intracranial meningioma compared to controls.

Journal Article Int J Cancer · October 15, 2011 Meningioma, the most frequent tumor in the central nervous system, has few recognized risk factors. We explored the role of allergies in a population-based case-control consortium study of meningioma in five geographic areas. We also studied serum levels o ... Full text Link to item Cite

Activating mutation in MET oncogene in familial colorectal cancer.

Journal Article BMC Cancer · October 4, 2011 BACKGROUND: In developed countries, the lifetime risk of developing colorectal cancer (CRC) is 5%, and it is the second leading cause of death from cancer. The presence of family history is a well established risk factor with 25-35% of CRCs attributable to ... Full text Link to item Cite

Assessment of hepatocyte growth factor in ovarian cancer mortality.

Journal Article Cancer Epidemiol Biomarkers Prev · August 2011 BACKGROUND: Invasive ovarian cancer is a significant cause of gynecologic cancer mortality. METHODS: We examined whether this mortality was associated with inherited variation in approximately 170 candidate genes/regions [993 single-nucleotide polymorphism ... Full text Link to item Cite

MicroRNA processing and binding site polymorphisms are not replicated in the Ovarian Cancer Association Consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · August 2011 BACKGROUND: Single nucleotide polymorphisms (SNP) in microRNA-related genes have been associated with epithelial ovarian cancer (EOC) risk in two reports, yet associated alleles may be inconsistent across studies. METHODS: We conducted a pooled analysis of ... Full text Link to item Cite

Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy.

Journal Article Epigenetics · July 2011 Folic acid (FA) supplementation before and during pregnancy has been associated with decreased risk of neural tube defects although recent reports suggest it may also increase the risk of other chronic diseases. We evaluated exposure to maternal FA supplem ... Full text Open Access Link to item Cite

Reported symptoms before and one year after hysterectomy in African American and white women.

Journal Article J Womens Health (Larchmt) · July 2011 PURPOSE: Although African American women are more likely than white women to undergo hysterectomy, there are few data describing their symptoms before and after surgery. This report compares reported symptoms in white and African American women before and ... Full text Link to item Cite

LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer.

Journal Article Cancer Res · June 1, 2011 Defective microRNA (miRNA) biogenesis contributes to the development and progression of epithelial ovarian cancer (EOC). In this study, we examined the hypothesis that single nucleotide polymorphisms (SNP) in miRNA biogenesis genes may influence EOC risk. ... Full text Link to item Cite

Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk.

Journal Article Hum Mol Genet · June 1, 2011 The insulin-like growth factor (IGF) signaling axis plays an important role in cancer biology. We hypothesized that genetic variation in this pathway may influence risk of ovarian cancer. A three-center study of non-Hispanic whites including 1880 control w ... Full text Link to item Cite

The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing.

Journal Article Clin Cancer Res · June 1, 2011 PURPOSE: An assay for the single-nucleotide polymorphism (SNP), rs61764370, has recently been commercially marketed as a clinical test to aid ovarian cancer risk evaluation in women with family histories of the disease. rs67164370 is in a 3'-UTR miRNA bind ... Full text Link to item Cite

Inherited variants in mitochondrial biogenesis genes may influence epithelial ovarian cancer risk.

Journal Article Cancer Epidemiol Biomarkers Prev · June 2011 BACKGROUND: Mitochondria contribute to oxidative stress, a phenomenon implicated in ovarian carcinogenesis. We hypothesized that inherited variants in mitochondrial-related genes influence epithelial ovarian cancer (EOC) susceptibility. METHODS: Through a ... Full text Link to item Cite

Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer.

Journal Article Int J Cancer · May 1, 2011 Common germline genetic variation in the population is associated with susceptibility to epithelial ovarian cancer. Microcell-mediated chromosome transfer and expression microarray analysis identified nine genes associated with functional suppression of tu ... Full text Link to item Cite

Xenobiotic-Metabolizing gene polymorphisms and ovarian cancer risk.

Journal Article Mol Carcinog · May 2011 Because selected xenobiotic-metabolizing enzymes process pro-carcinogens that could initiate ovarian carcinogenesis, we hypothesized that single nucleotide polymorphisms (SNPs) in the genes encoding xenobiotic-metabolizing enzymes are associated with risk ... Full text Link to item Cite

Prostate cancer susceptibility polymorphism rs2660753 is not associated with invasive ovarian cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2011 BACKGROUND: We previously reported an association between rs2660753, a prostate cancer susceptibility polymorphism, and invasive epithelial ovarian cancer (EOC; OR = 1.2, 95% CI=1.0-1.4, P(trend) = 0.01) that showed a stronger association with the serous h ... Full text Link to item Cite

Recreational physical activity and ovarian cancer risk and survival.

Journal Article Ann Epidemiol · March 2011 PURPOSE: Physical activity may influence ovarian cancer risk and outcomes through effects on ovulation, inflammatory markers, and other processes. We examined associations between self-reported physical activity and ovarian cancer risk and survival in a po ... Full text Link to item Cite

Endometrial cancer.

Journal Article Gynecol Oncol · February 2011 Full text Link to item Cite

Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST).

Journal Article BMC Public Health · January 21, 2011 BACKGROUND: Folic acid (FA) added to foods during fortification is 70-85% bioavailable compared to 50% of folate occurring naturally in foods. Thus, if FA supplements also are taken during pregnancy, both mother and fetus can be exposed to FA exceeding the ... Full text Open Access Link to item Cite

Polymorphisms in stromal genes and susceptibility to serous epithelial ovarian cancer: a report from the Ovarian Cancer Association Consortium.

Journal Article PLoS One · 2011 Alterations in stromal tissue components can inhibit or promote epithelial tumorigenesis. Decorin (DCN) and lumican (LUM) show reduced stromal expression in serous epithelial ovarian cancer (sEOC). We hypothesized that common variants in these genes associ ... Full text Link to item Cite

Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort.

Journal Article Fertil Steril · January 2011 OBJECTIVE: To investigate the association between self-reported endometriosis and the putative functional promoter +331C/T single nucleotide polymorphism and the PROGINS allele. DESIGN: Control subjects from ovarian cancer case-control studies participatin ... Full text Link to item Cite

Estrogen receptor beta rs1271572 polymorphism and invasive ovarian carcinoma risk: pooled analysis within the Ovarian Cancer Association Consortium.

Journal Article PLoS One · 2011 The association of ovarian carcinoma risk with the polymorphism rs1271572 in the estrogen receptor beta (ESR2) gene was examined in 4946 women with primary invasive ovarian carcinoma and 6582 controls in a pooled analysis of ten case-control studies within ... Full text Link to item Cite

Evaluation of established breast cancer risk factors as modifiers of BRCA1 or BRCA2: a multi-center case-only analysis.

Journal Article Breast Cancer Res Treat · November 2010 The incomplete penetrance of mutations in BRCA1 and BRCA2 suggests that some combination of environmental and genetic factors modifies the risk of breast cancer in mutation carriers. This study sought to identify possible interactions between established b ... Full text Link to item Cite

A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.

Journal Article Nat Genet · October 2010 Ovarian cancer accounts for more deaths than all other gynecological cancers combined. To identify common low-penetrance ovarian cancer susceptibility genes, we conducted a genome-wide association study of 507,094 SNPs in 1,768 individuals with ovarian can ... Full text Link to item Cite

Common variants at 19p13 are associated with susceptibility to ovarian cancer.

Journal Article Nat Genet · October 2010 Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 indi ... Full text Link to item Cite

Survey of familial glioma and role of germline p16INK4A/p14ARF and p53 mutation.

Journal Article Fam Cancer · September 2010 There is increasing recognition of familial propensity to glioma as a distinct clinical entity beyond a few rare syndromes; however its genetic basis is poorly understood. The role of p16(INK4A)/p14(ARF) and p53 mutations in sporadic glioma provides a stro ... Full text Link to item Cite

Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality.

Journal Article JAMA · September 1, 2010 CONTEXT: Mastectomy and salpingo-oophorectomy are widely used by carriers of BRCA1 or BRCA2 mutations to reduce their risks of breast and ovarian cancer. OBJECTIVE: To estimate risk and mortality reduction stratified by mutation and prior cancer status. DE ... Full text Link to item Cite

BAYESIAN MODEL SEARCH AND MULTILEVEL INFERENCE FOR SNP ASSOCIATION STUDIES.

Journal Article Ann Appl Stat · September 1, 2010 Technological advances in genotyping have given rise to hypothesis-based association studies of increasing scope. As a result, the scientific hypotheses addressed by these studies have become more complex and more difficult to address using existing analyt ... Full text Open Access Link to item Cite

Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".

Journal Article PLoS Genet · July 8, 2010 We hypothesized that variants in genes expressed as a consequence of interactions between ovarian cancer cells and the host micro-environment could contribute to cancer susceptibility. We therefore used a two-stage approach to evaluate common single nucleo ... Full text Link to item Cite

Primary peritoneal and ovarian cancers: an epidemiological comparative analysis.

Journal Article Cancer Causes Control · July 2010 We performed case-control analyses using data from the North Carolina Ovarian Cancer Study to determine risk factors that distinguish primary peritoneal cancer (PPC) from epithelial ovarian cancer (EOC). Our risk factor analyses were restricted to invasive ... Full text Link to item Cite

Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · July 2010 BACKGROUND: We previously reported the risks of ovarian carcinoma for common polymorphisms in one-carbon transfer genes. We sought to replicate associations for DPYD rs1801265, DNMT3A rs13420827, MTHFD1 rs1950902, MTHFS rs17284990, and TYMS rs495139 with r ... Full text Link to item Cite

Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".

Journal Article PLoS genetics · July 1, 2010 We hypothesized that variants in genes expressed as a consequence of interactions between ovarian cancer cells and the host micro-environment could contribute to cancer susceptibility. We therefore used a two-stage approach to evaluate common single nucleo ... Cite

Association between DNA damage response and repair genes and risk of invasive serous ovarian cancer.

Journal Article PLoS One · April 8, 2010 BACKGROUND: We analyzed the association between 53 genes related to DNA repair and p53-mediated damage response and serous ovarian cancer risk using case-control data from the North Carolina Ovarian Cancer Study (NCOCS), a population-based, case-control st ... Full text Open Access Link to item Cite

Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer.

Journal Article Twin Res Hum Genet · February 2010 Featured Publication The chromosome 8q24 region (specifically, 8q24.21.a) is known to harbor variants associated with risk of breast, colorectal, prostate, and bladder cancers. In 2008, variants rs10505477 and rs6983267 in this region were associated with increased risk of inv ... Full text Link to item Cite

Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · February 2010 Featured Publication Aberrant glycosylation is a well-described hallmark of cancer. In a previous ovarian cancer case control study that examined polymorphisms in 26 glycosylation-associated genes, we found strong statistical evidence (P = 0.00017) that women who inherited two ... Full text Link to item Cite

Inherited determinants of ovarian cancer survival.

Journal Article Clin Cancer Res · February 1, 2010 Featured Publication PURPOSE: Due to variation of outcome among cases, we sought to examine whether overall survival in ovarian cancer was associated with common inherited variants in 227 candidate genes from ovarian cancer-related pathways including angiogenesis, inflammation ... Full text Link to item Cite

Risk of ovarian cancer and inherited variants in relapse-associated genes.

Journal Article PLoS One · January 27, 2010 Featured Publication BACKGROUND: We previously identified a panel of genes associated with outcome of ovarian cancer. The purpose of the current study was to assess whether variants in these genes correlated with ovarian cancer risk. METHODS AND FINDINGS: Women with and withou ... Full text Open Access Link to item Cite

ESR1/SYNE1 polymorphism and invasive epithelial ovarian cancer risk: an Ovarian Cancer Association Consortium study.

Journal Article Cancer Epidemiol Biomarkers Prev · January 2010 Featured Publication We genotyped 13 single nucleotide polymorphisms (SNPs) in the estrogen receptor alpha gene (ESR1) region in three population-based case-control studies of epithelial ovarian cancer conducted in the United States, comprising a total of 1,128 and 1,866 non-H ... Full text Link to item Cite

IGF2R polymorphisms and risk of esophageal and gastric adenocarcinomas.

Journal Article Int J Cancer · December 1, 2009 Featured Publication The mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) encodes a protein that plays a critical role in tumor suppression, in part by modulating bioavailability of a potent mitogen, insulin-like growth factor-2 (IGF2). We tested the hypot ... Full text Link to item Cite

Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.

Journal Article Br J Cancer · October 20, 2009 BACKGROUND: Dysregulation of the cell cycle is a hallmark of many cancers including ovarian cancer, a leading cause of gynaecologic cancer mortality worldwide. METHODS: We examined single nucleotide polymorphisms (SNPs) (n=288) from 39 cell cycle regulatio ... Full text Link to item Cite

A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2.

Journal Article Nat Genet · September 2009 Featured Publication Epithelial ovarian cancer has a major heritable component, but the known susceptibility genes explain less than half the excess familial risk. We performed a genome-wide association study (GWAS) to identify common ovarian cancer susceptibility alleles. We ... Full text Link to item Cite

Ovarian cancer risk factors in African-American and white women.

Journal Article Am J Epidemiol · September 1, 2009 Featured Publication Ovarian cancer is the most lethal gynecologic malignancy in both African-American and white women. Although prevalences of many ovarian cancer risk factors differ markedly between African Americans and whites, there has been little research on how the rela ... Full text Link to item Cite

Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer.

Journal Article Gynecol Oncol · August 2009 Featured Publication OBJECTIVE: We have previously shown that TCEAL7 (transcription elongation factor A (SII)-like 7) is epigenetically down-regulated in the majority of epithelial ovarian cancers. We now examine the hypothesis that inherited alterations in TCEAL7 play a role ... Full text Link to item Cite

Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men.

Journal Article J Natl Med Assoc · July 2009 Featured Publication BACKGROUND: Individual variation in circulating insulinlike growth factor-1 (IGF1) and its major binding protein, insulinlike growth factor binding protein-3 (IGFBP3), have been etiologically linked to several chronic diseases, including some cancers. Fact ... Full text Link to item Cite

Association between common germline genetic variation in 94 candidate genes or regions and risks of invasive epithelial ovarian cancer.

Journal Article PLoS One · June 19, 2009 Featured Publication BACKGROUND: Recent studies have identified several single nucleotide polymorphisms (SNPs) in the population that are associated with variations in the risks of many different diseases including cancers such as breast, prostate and colorectal. For ovarian c ... Full text Link to item Cite

Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study.

Journal Article Hum Mol Genet · June 15, 2009 Featured Publication Because both ovarian and breast cancer are hormone-related and are known to have some predisposition genes in common, we evaluated 11 of the most significant hits (six with confirmed associations with breast cancer) from the breast cancer genome-wide assoc ... Full text Link to item Cite

Polymorphisms in NF-kappaB inhibitors and risk of epithelial ovarian cancer.

Journal Article BMC Cancer · June 6, 2009 Featured Publication BACKGROUND: The nuclear factor-kappaB (NF-kappaB) family is a set of transcription factors with key roles in the induction of the inflammatory response and may be the link between inflammation and cancer development. This pathway has been shown to influenc ... Full text Link to item Cite

A prospective study of weight gain after premenopausal hysterectomy.

Journal Article J Womens Health (Larchmt) · May 2009 Featured Publication PURPOSE: Many women who have had hysterectomies have the perception that they gained weight after surgery that cannot be attributed to changes in diet or physical activity. The purpose of this analysis was to assess weight gain in premenopausal women in th ... Full text Link to item Cite

Role of genetic polymorphisms and ovarian cancer susceptibility.

Journal Article Mol Oncol · April 2009 Featured Publication The value of identifying women with an inherited predisposition to epithelial ovarian cancer has become readily apparent with the identification of the BRCA1, and BRCA2 genes. Women who inherit a deleterious mutation in either of these genes have a very hi ... Full text Link to item Cite

Association between glioma and history of allergies, asthma, and eczema: a case-control study with three groups of controls.

Journal Article Cancer Epidemiol Biomarkers Prev · April 2009 Featured Publication Because glioma etiology is largely unknown, the inverse association of glioma risk with atopic conditions is promising and deserves close scrutiny. We examined the association between a history of allergies, asthma, and eczema, and glioma risk using siblin ... Full text Link to item Cite

Single nucleotide polymorphisms in the TP53 region and susceptibility to invasive epithelial ovarian cancer.

Journal Article Cancer Res · March 15, 2009 Featured Publication The p53 protein is critical for multiple cellular functions including cell growth and DNA repair. We assessed whether polymorphisms in the region encoding TP53 were associated with risk of invasive ovarian cancer. The study population includes a total of 5 ... Full text Link to item Cite

Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2009 Featured Publication Polymorphisms in genes critical to cell cycle control are outstanding candidates for association with ovarian cancer risk; numerous genes have been interrogated by multiple research groups using differing tagging single-nucleotide polymorphism (SNP) sets. ... Full text Link to item Cite

Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium.

Journal Article Br J Cancer · January 27, 2009 Featured Publication The search for genetic variants associated with ovarian cancer risk has focused on pathways including sex steroid hormones, DNA repair, and cell cycle control. The Ovarian Cancer Association Consortium (OCAC) identified 10 single-nucleotide polymorphisms ( ... Full text Link to item Cite

Sampling strategies for tissue microarrays to evaluate biomarkers in ovarian cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · January 2009 INTRODUCTION: Tissue microarrays (TMA) enable rapid analysis of biomarkers in large-scale studies involving archival tumor specimens, however, their utility in heterogeneous tumors such as ovarian cancer is limited. METHODS: In this study, immunohistochemi ... Full text Link to item Cite

Cancer genetic counseling in rural north carolina oncology clinics: Program establishment and patient characteristics

Journal Article Community Oncology · January 1, 2009 Cancer genetic counseling (CGC) has become standard of care for individuals at increased risk of hereditary cancer. However, because access to CGC is limited in rural communities, several groups are underserved by CGC, and little knowledge exists about cha ... Full text Cite

Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.

Journal Article Cancer Epidemiol Biomarkers Prev · December 2008 Featured Publication Over 22,000 cases of ovarian cancer were diagnosed in 2007 in the United States, but only a fraction of them can be attributed to mutations in highly penetrant genes such as BRCA1. To determine whether low-penetrance genetic variants contribute to ovarian ... Full text Link to item Cite

Common familial colorectal cancer linked to chromosome 7q31: a genome-wide analysis.

Journal Article Cancer Res · November 1, 2008 Featured Publication Present investigations suggest that approximately 30% of colorectal cancer cases arise on the basis of inherited factors. We hypothesize that the majority of inherited factors are moderately penetrant genes, common in the population. We use an affected sib ... Full text Link to item Cite

Flexible Frames and Control Sampling in Case-Control Studies: Weighters (Survey Statisticians) Versus Anti-Weighters (Epidemiologists).

Journal Article Am Stat · November 1, 2008 Featured Publication We propose two innovations in statistical sampling for controls to enable better design of population-based case-control studies. The main innovation leads to novel solutions, without using weights, of the difficult and long-standing problem of selecting a ... Full text Link to item Cite

Consortium analysis of 7 candidate SNPs for ovarian cancer.

Journal Article Int J Cancer · July 15, 2008 Featured Publication The Ovarian Cancer Association Consortium selected 7 candidate single nucleotide polymorphisms (SNPs), for which there is evidence from previous studies of an association with variation in ovarian cancer or breast cancer risks. The SNPs selected for analys ... Full text Link to item Cite

Performance of amplified DNA in an Illumina GoldenGate BeadArray assay.

Journal Article Cancer Epidemiol Biomarkers Prev · July 2008 Featured Publication Whole genome amplification (WGA) offers a means to enrich DNA quantities for epidemiologic studies. We used an ovarian cancer study of 1,536 single nucleotide polymorphisms (SNPs) and 2,368 samples to assess performance of multiple displacement amplificati ... Full text Link to item Cite

Hormonal risk factors for ovarian cancer in premenopausal and postmenopausal women.

Journal Article Am J Epidemiol · May 1, 2008 Featured Publication Ovarian cancer is most frequently diagnosed in postmenopausal women; however, the strongest risk predictors, pregnancy and oral contraceptive use, occur in most women in their twenties and thirties. Relatively few studies have examined how reproductive ris ... Full text Link to item Cite

Genetic variation in the one-carbon transfer pathway and ovarian cancer risk.

Journal Article Cancer Res · April 1, 2008 Featured Publication Dysfunction in enzymes involved in one-carbon (1-C) metabolism can lead to increased chromosomal strand breaking and abnormal methylation patterns, which are both associated with cancer risk. Availability of 1-C units may modify risk. We investigated the a ... Full text Link to item Cite

Cyclin E overexpression in epithelial ovarian cancer characterizes an etiologic subgroup.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2008 Featured Publication BACKGROUND: The objective of this study was to determine whether cyclin E overexpression defines an etiologically distinct subgroup of ovarian cancer. METHODS: We analyzed data from 538 epithelial ovarian cancer cases and 629 controls enrolled in a populat ... Full text Link to item Cite

Association of single nucleotide polymorphisms in glycosylation genes with risk of epithelial ovarian cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · February 2008 Featured Publication Studies suggest that underglycosylation of the cell membrane mucin MUC1 may be associated with epithelial ovarian cancer. We identified 26 genes involved in glycosylation and examined 93 single nucleotide polymorphisms (SNP) with a minor allele frequency o ... Full text Link to item Cite

Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the Ovarian Cancer Association Consortium pooled analysis.

Journal Article Br J Cancer · January 29, 2008 There is evidence that progesterone plays a role in the aetiology of invasive epithelial ovarian cancer. Therefore, genes involved in pathways that regulate progesterone may be candidates for susceptibility to this disease. Previous studies have suggested ... Full text Link to item Cite

Factors associated with African Americans' enrollment in a national cancer genetics registry.

Journal Article Community Genet · 2008 Featured Publication This study explored whether reactions to the Cancer Genetics Network (CGN) or CGN enrollment differed by receipt of a standard informational brochure versus a targeted version addressing factors previously associated with African Americans' health behavior ... Full text Link to item Cite

Flexible Frames and Control Sampling in Case-Control Studies

Journal Article The American Statistician · 2008 Cite

Validity of models for predicting BRCA1 and BRCA2 mutations.

Journal Article Ann Intern Med · October 2, 2007 BACKGROUND: Deleterious mutations of the BRCA1 and BRCA2 genes confer susceptibility to breast and ovarian cancer. At least 7 models for estimating the probabilities of having a mutation are used widely in clinical and scientific activities; however, the m ... Full text Link to item Cite

Exogenous hormone use and meningioma risk: what do we tell our patients?

Journal Article Cancer · August 1, 2007 The decision to commence or continue use of hormone replacement therapy or oral contraceptives in women presumed or known to be diagnosed with intracranial meningioma is a common clinical question in neurosurgery. A review of the English-language literatur ... Full text Link to item Cite

Grade-specific prostate cancer associations of IGF1 (CA)19 repeats and IGFBP3-202A/C in blacks and whites.

Journal Article J Natl Med Assoc · July 2007 Carrying the cytosine-adenosine (CA)19 repeat polymorphism in insulin-like growth factor-1 (IGF1) is associated with lower serum proteins and decreased prostate cancer risk. Carrying the -202A/C genotype in insulin-like growth factor binding protein-3 (IGF ... Link to item Cite

Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer.

Journal Article Cancer Res · April 1, 2007 High-risk susceptibility genes explain <40% of the excess risk of familial ovarian cancer. Therefore, other ovarian cancer susceptibility genes are likely to exist. We have used a single nucleotide polymorphism (SNP)-tagging approach to evaluate common var ... Full text Link to item Cite

Trinucleotide repeat polymorphisms in the androgen receptor gene and risk of ovarian cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2007 INTRODUCTION: Androgens may play a role in the development of ovarian cancers. Two trinucleotide repeat polymorphisms have been described in exon 1 of the androgen receptor (AR) gene that may affect its function. Previous studies of ovarian cancer and AR r ... Full text Link to item Cite

Progestin and estrogen potency of combination oral contraceptives and endometrial cancer risk.

Journal Article Gynecol Oncol · November 2006 OBJECTIVE: Using data from a case-control study of endometrial cancer, we investigated the relationship between the progestin and estrogen potency in combination oral contraceptives (OCs) and the risk of developing endometrial cancer. METHODS: Subjects inc ... Full text Link to item Cite

Characterization of BRCA1 and BRCA2 mutations in a large United States sample.

Journal Article J Clin Oncol · February 20, 2006 PURPOSE: An accurate evaluation of the penetrance of BRCA1 and BRCA2 mutations is essential to the identification and clinical management of families at high risk of breast and ovarian cancer. Existing studies have focused on Ashkenazi Jews (AJ) or on fami ... Full text Link to item Cite

Analgesic drug use and risk of ovarian cancer.

Journal Article Epidemiology · January 2006 BACKGROUND: Previous epidemiologic research suggests that analgesic use may reduce the risk of ovarian cancer, although results are not consistent. METHODS: In a population-based, case-control study, we analyzed data from 586 ovarian cancer cases and 627 m ... Full text Link to item Cite

Analysis of co-aggregation of cancer based on registry data.

Journal Article Community Genet · 2006 OBJECTIVE: An exploratory analysis of co-aggregation of cancers using registry-based data. METHODS: We utilized sibships from over 18,000 families who had been recruited to the NCI-sponsored multi-institutional Cancer Genetics Network. The analysis assesse ... Full text Link to item Cite

High expression of insulin-like growth factor binding protein-2 messenger RNA in epithelial ovarian cancers produces elevated preoperative serum levels.

Journal Article Int J Gynecol Cancer · 2006 The molecular etiology of epithelial ovarian cancer remains unclear. Using microarray expression analysis, we recently reported that expression of the insulin-like growth factor binding protein-2 (IGFBP-2) gene is elevated in advanced epithelial ovarian ca ... Full text Link to item Cite

Epidemiology of intracranial meningioma.

Journal Article Neurosurgery · December 2005 Meningiomas are the most frequently reported primary intracranial neoplasms, accounting for approximately 25% of all such lesions diagnosed in the United States. Few studies have examined the risk factors associated with a diagnosis of meningioma with two ... Full text Link to item Cite

Estrogen bioactivation, genetic polymorphisms, and ovarian cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · November 2005 Recent experimental evidence has shown that catechol estrogens can be activated through metabolism to form depurinating DNA adducts and thereby initiate cancer. Limited data are available regarding this pathway in epithelial ovarian cancer. We conducted a ... Full text Link to item Cite

Complex Genetic Interactions

Journal Article · October 7, 2005 Full text Cite

Anthropometric measurements and epithelial ovarian cancer risk in African-American and White women.

Journal Article Cancer Causes Control · October 2005 Previous studies of anthropometric factors and ovarian cancer risk have been inconsistent and none have evaluated the association among African-American women. Data from a population-based, case-control study of 593 cases and 628 controls were used to eval ... Full text Link to item Cite

Menopausal hormones and risk of ovarian cancer.

Journal Article Am J Obstet Gynecol · July 2005 OBJECTIVE: The objective of this study was to determine if use of menopausal hormones was associated with ovarian cancer and if risk varied by type of hormone used. STUDY DESIGN: Data from a population-based, case-control study of ovarian cancer in North C ... Full text Link to item Cite

BRAF polymorphisms and the risk of ovarian cancer of low malignant potential.

Journal Article Gynecol Oncol · June 2005 OBJECTIVE: The object of this study was to test the hypothesis that BRAF is a low-risk susceptibility gene for low malignant potential (LMP) ovarian cancer. A recent study of the relationship between BRAF polymorphisms and malignant melanoma identified str ... Full text Link to item Cite

Transforming growth factor beta receptor I polyalanine repeat polymorphism does not increase ovarian cancer risk.

Journal Article Gynecol Oncol · May 2005 OBJECTIVES: It has been suggested that the 6A allele of the type I TGFbeta receptor (TGFbetaR1) polyalanine repeat tract polymorphism may increase susceptibility to various types of cancer including ovarian cancer. METHODS: The TGFbetaR1 polyalanine polymo ... Full text Link to item Cite

Antidepressant medication use [corrected] and risk of ovarian cancer.

Journal Article Obstet Gynecol · April 2005 OBJECTIVE: It has been hypothesized that antidepressants may enhance cancer growth. Previous studies of antidepressant use and ovarian cancer have been inconsistent and have been limited in their ability to examine the association with selective serotonin ... Full text Link to item Cite

Impact of the Cancer Risk Intake System on patient-clinician discussions of tamoxifen, genetic counseling, and colonoscopy.

Journal Article J Gen Intern Med · April 2005 The Cancer Risk Intake System (CRIS), a computerized program that "matches" objective cancer risks to appropriate risk management recommendations, was designed to facilitate patient-clinician discussion. We evaluated CRIS in primary care settings via a sin ... Full text Link to item Cite

IGF1 (CA)19 repeat and IGFBP3 -202 A/C genotypes and the risk of prostate cancer in Black and White men.

Journal Article Cancer Epidemiol Biomarkers Prev · February 2005 We investigated the relationship between the insulin-like growth factor-1 (IGF1) cytosine-adenine repeat (CA)(19) polymorphism located upstream of the gene's transcription start site, the insulin-like growth factor binding protein-3 (IGFBP3) -202 A/C promo ... Full text Link to item Cite

Flushing and papules in a middle-aged woman.

Journal Article Obstet Gynecol · February 2005 Full text Link to item Cite

Progesterone receptor promoter +331A polymorphism is associated with a reduced risk of endometrioid and clear cell ovarian cancers.

Journal Article Cancer Epidemiol Biomarkers Prev · December 2004 OBJECTIVE: The progestagenic milieu of pregnancy and oral contraceptive use is protective against epithelial ovarian cancer. A functional single nucleotide polymorphism in the promoter of the progesterone receptor (+331A) alters the relative abundance of t ... Link to item Cite

Oral contraceptive use, reproductive history, and risk of epithelial ovarian cancer in women with and without endometriosis.

Journal Article Am J Obstet Gynecol · September 2004 OBJECTIVE: Women with endometriosis may be at an increased risk of ovarian cancer. It is not known whether reproductive factors that reduce the risk of ovarian cancer in general also reduce risk in women with endometriosis. We investigated whether the odds ... Full text Link to item Cite

Racial differences in enrolment in a cancer genetics registry.

Journal Article Cancer Epidemiol Biomarkers Prev · August 2004 BACKGROUND: Lower enrolment of minorities into research studies has been reported frequently. Most studies have little information about nonparticipants, making it difficult to identify characteristics associated with enrolment and how they might vary by r ... Link to item Cite

Polymorphisms in BRCA1 and BRCA2 and risk of epithelial ovarian cancer.

Journal Article Clin Cancer Res · October 1, 2003 PURPOSE: Because inherited BRCA1 or BRCA2 mutations strikingly increase ovarian cancer risk, polymorphisms in these genes could represent low penetrance susceptibility alleles. Previous studies of the BRCA2 N372H polymorphism suggested that HH homozygotes ... Link to item Cite

Matrix metalloproteinase-1 gene promoter polymorphism and risk of ovarian cancer.

Journal Article J Soc Gynecol Investig · September 2003 OBJECTIVE: It has been suggested that the 2G allele of a guanine insertion-deletion promoter polymorphism in the promoter of the matrix metalloproteinase-1 (MMP1) gene may increase susceptibility to ovarian cancer. The 2G allele also has been associated wi ... Full text Link to item Cite

Characterization of prediagnostic symptoms among primary epithelial ovarian cancer cases and controls.

Journal Article Gynecol Oncol · July 2003 OBJECTIVE: The goal of this study was to characterize types, frequency, combinations, and relative onset of symptoms among ovarian cancer cases and controls. METHODS: Participants were from an ongoing, population-based, case-control study of primary epithe ... Full text Link to item Cite

High expression of tumor necrosis factor-related apoptosis-inducing ligand is associated with favorable ovarian cancer survival.

Journal Article Clin Cancer Res · February 2003 PURPOSE: The molecular determinants of survival in ovarian cancer are poorly understood. Using expression microarrays, we recently found that high expression of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene is associated with pro ... Link to item Cite

The Cancer Genetics Network: recruitment results and pilot studies.

Journal Article Community Genet · 2003 OBJECTIVE: The National Cancer Institute established the Cancer Genetics Network (CGN) to support collaborative investigations into the genetic basis of cancer susceptibility, explore mechanisms to integrate this new knowledge into medical practice, and id ... Full text Link to item Cite

Ovulation and ovarian cancer: a comparison of two methods for calculating lifetime ovulatory cycles (United States).

Journal Article Cancer Causes Control · November 2002 OBJECTIVE: To compare two methods for calculating lifetime ovulatory cycles (LOC) to determine if more detailed menstrual cycle information results in stronger associations with ovarian cancer. METHODS: Using data from 232 cases and 242 controls in a popul ... Full text Link to item Cite

Impact of progestin and estrogen potency in oral contraceptives on ovarian cancer risk.

Journal Article J Natl Cancer Inst · January 2, 2002 BACKGROUND: Oral contraceptive (OC) use is associated with a reduced risk of developing ovarian cancer, but the mechanism for the risk reduction has not been well defined. In this study, we investigate the relationship between the progestin and estrogen po ... Full text Link to item Cite

Pre-counseling education materials for BRCA testing: does tailoring make a difference?

Journal Article Genet Test · 2002 Although tailored print materials (TPMs) have been assessed for a variety of behavioral targets, their effectiveness as decision aids for genetic testing had not been evaluated at the time this study began. We compared TPMs and non-tailored print material ... Full text Link to item Cite

Types and duration of symptoms prior to diagnosis of invasive or borderline ovarian tumor.

Journal Article Gynecol Oncol · December 2001 OBJECTIVE: The objective was to describe and compare types and duration of symptoms among women with invasive versus borderline ovarian tumors. METHODS: Cases were women, ages 20-69 years, diagnosed with invasive (616) and borderline (151) epithelial ovari ... Full text Link to item Cite

Age at natural menopause and the risk of epithelial ovarian cancer.

Journal Article Obstet Gynecol · July 2001 OBJECTIVE: To investigate the relationship between age at natural menopause and risk of developing epithelial ovarian cancer. METHODS: Using data from six population-based, case-control studies conducted in the United States, age at natural menopause among ... Full text Link to item Cite

Comparison of two methods for calculating lifetime ovulatory cycles.

Journal Article AMERICAN JOURNAL OF EPIDEMIOLOGY · June 1, 2001 Link to item Cite

Testing for hereditary breast and ovarian cancer in the southeastern United States.

Journal Article Ann Surg · May 2000 OBJECTIVES: To detail characterization of mutations and uncharacterized variants in the breast cancer susceptibility genes BRCA1 and BRCA2, as observed in a population of breast cancer patients from the southeastern United States, and to examine baseline c ... Full text Link to item Cite

Genetic Susceptibility and Survival: Application to Breast Cancer

Journal Article Journal of the American Statistical Association · March 1, 2000 Inherited mutations of the BRCA1 and BRCA2 genes are known to confer an elevated risk of both breast and ovarian cancers. The effect of carrying such a mutation on survival after developing breast or ovarian cancer is less well understood. We investigate t ... Full text Cite

Early onset baldness and prostate cancer risk.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2000 Prostatic carcinoma is the leading cancer among American men, yet few risk factors have been established. Although increased androgen levels have long been associated with both prostatic carcinoma and baldness, to date no studies have shown an association ... Link to item Cite

Cigarette smoking and epithelial ovarian cancer by histologic type.

Journal Article Obstet Gynecol · February 2000 OBJECTIVE: To examine cigarette smoking as a risk factor for different types of epithelial ovarian cancer. METHODS: We used data from the Cancer and Steroid Hormone Study, a multicenter, population-based, case control investigation. Cases were 447 women ag ... Full text Link to item Cite

Prognostic factors in early-onset epithelial ovarian cancer: a population-based study.

Journal Article Obstet Gynecol · January 2000 OBJECTIVE: To investigate the clinical prognostic factors that influence ovarian cancer survival in women with early-onset epithelial ovarian cancer using population-based data. METHODS: Subjects in the current study were from a population-based series of ... Full text Link to item Cite

Managing hereditary ovarian cancer risk.

Journal Article Cancer · December 1, 1999 Ovarian cancer is the fourth leading cause of cancer deaths in American women. About 10% of cases are thought to have a hereditary basis, and family history is the strongest known risk factor. In the past, prophylactic oophorectomy has been advocated for w ... Full text Link to item Cite

Relationship between alterations in the p53 tumor suppressor gene and prognosis of ovarian cancer

Journal Article CME Journal of Gynecologic Oncology · December 1, 1999 Mutation and overexpression of the p53 tumor suppressor gene are the most frequently described genetic alterations noted thus far in epithelial ovarian cancers; and it is thought that loss of p53 tumor suppressor function plays a significant role in the pa ... Cite

Managing hereditary ovarian cancer risk

Journal Article Cancer · October 15, 1999 Ovarian cancer is the fourth leading cause of cancer deaths in American women. About 10% of cases are thought to have a hereditary basis, and family history is the strongest known risk factor. In the past, prophylactic oophorectomy has been advocated for w ... Full text Cite

Pregnancy recency and risk of ovarian cancer.

Journal Article Cancer Causes Control · October 1999 OBJECTIVE: A recent analysis suggested that ovarian cancer risk increased with time since last birth, possibly because of some aspect of pregnancy that affects the clearance of cells that have undergone malignant transformation. We analyzed data from four ... Full text Link to item Cite

Association between low levels of 1,25-dihydroxyvitamin D and breast cancer risk.

Journal Article Public Health Nutr · September 1999 OBJECTIVE: To determine if blood levels of 25-hydroxyvitamin D (25-D) or its active metabolite, 1,25-dihydroxyvitamin D (1,25-D), are lower in women at the time of first diagnosis of breast cancer than in comparable women without breast cancer. DESIGN: Thi ... Full text Link to item Cite

A Bayesian hierarchical approach for combining case-control and prospective studies.

Journal Article Biometrics · September 1999 Motivated by the absolute risk predictions required in medical decision making and patient counseling, we propose an approach for the combined analysis of case-control and prospective studies of disease risk factors. The approach is hierarchical to account ... Full text Link to item Cite

Ethical ramifications of alternative means of recruiting research participants from cancer registries.

Journal Article Cancer · August 15, 1999 BACKGROUND: The protection of confidentiality and the extent to which voluntary and meaningful informed consent can be obtained from potential participants are critical when recruiting patients for clinical research from cancer registries. In the current s ... Full text Link to item Cite

Prostate cancer: demographic and behavioral correlates of stage at diagnosis among blacks and whites in North Carolina.

Journal Article Urology · June 1999 OBJECTIVES: Although stage at diagnosis is one of the most important predictors of survival from prostate cancer, demographic factors, screening practices, and knowledge and beliefs associated with stage at diagnosis have not been well documented, particul ... Full text Link to item Cite

Attitudes, knowledge, and risk perceptions of women with breast and/or ovarian cancer considering testing for BRCA1 and BRCA2.

Journal Article J Clin Oncol · March 1999 PURPOSE: This study examined baseline knowledge, beliefs, and risk perceptions among a group of 200 women with breast and/or ovarian cancer who participated in a trial designed to improve decision making about genetic testing for BRCA1 and BRCA2. PATIENTS ... Full text Link to item Cite

Environmental contaminants and body fat distribution.

Journal Article Cancer Epidemiol Biomarkers Prev · February 1999 The effect of body mass index (BMI) and waist:hip ratio (WHR) on plasma levels of organochlorines [i.e., 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE)] was investigated in a sample of black and white women drawn from a population-based study in North ... Link to item Cite

Effect of BRCA1 and BRCA2 on the association between breast cancer risk and family history.

Journal Article J Natl Cancer Inst · December 2, 1998 BACKGROUND: The discovery of BRCA1 and BRCA2 has led to a reassessment of the association between family history of breast/ovarian cancer and breast cancer risk after controlling for carrier status for mutations in the BRCA1 and BRCA2 genes. We examined wh ... Full text Link to item Cite

Treatment options, selection, and satisfaction among African American and white men with prostate carcinoma in North Carolina.

Journal Article Cancer · July 15, 1998 BACKGROUND: In the U.S., prostate carcinoma mortality is greatest among African Americans. In North Carolina, the state with the fourth largest population of African Americans, the prostate carcinoma mortality rate is 2.5 times greater among African Americ ... Full text Link to item Cite

Pregnancy regency, menopausal status, and risk of ovarian cancer.

Journal Article AMERICAN JOURNAL OF EPIDEMIOLOGY · June 1, 1998 Link to item Cite

Increased risk for familial ovarian cancer among Jewish women: a population-based case-control study.

Journal Article Genet Epidemiol · 1998 Jewish women have been reported to have a higher risk for familial breast cancer than non-Jewish women and to be more likely to carry mutations in breast cancer genes such as BRCA1. Because BRCA1 mutations also increase women's risk for ovarian cancer, we ... Full text Link to item Cite

Genetic counseling and testing for breast-ovarian cancer susceptibility: what do women want?

Journal Article J Clin Oncol · January 1998 PURPOSE: To assess preferences for the content and process of genetic counseling and testing for breast-ovarian cancer susceptibility among women at high risk for breast cancer. METHODS: Ninety-eight healthy women who had a family history of breast cancer ... Full text Link to item Cite

Response

Journal Article JNCI Journal of the National Cancer Institute · November 19, 1997 Full text Cite

Relationship between lifetime ovulatory cycles and overexpression of mutant p53 in epithelial ovarian cancer.

Journal Article J Natl Cancer Inst · July 2, 1997 BACKGROUND: Several lines of evidence have suggested a relationship between a woman's number of ovulatory cycles and the development of ovarian epithelial cancer. Repair of the ovarian surface after ovulation requires cellular proliferation, and spontaneou ... Full text Link to item Cite

Probability of carrying a mutation of breast-ovarian cancer gene BRCA1 based on family history.

Journal Article J Natl Cancer Inst · February 5, 1997 BACKGROUND: Heritable mutations of the breast cancer gene BRCA1 are rare, occurring in fewer than 1% of women in the general population, and therefore account for a small proportion of cases of breast and ovarian cancers. Nevertheless, the presence of such ... Full text Link to item Cite

No association between alpha 1-antichymotrypsin and familial Alzheimer's disease.

Journal Article Ann N Y Acad Sci · December 16, 1996 Alzheimer's disease (AD) is the most common mid to late age-of-onset neurodegenerative disorder. AD has a strong and complex genetic etiology, and multiple genes, acting independently and/or interacting, likely affect the risk of developing AD. Several gen ... Full text Link to item Cite

Epithelial ovarian cancer risk among women with polycystic ovary syndrome.

Journal Article Obstet Gynecol · October 1996 OBJECTIVE: To investigate the relationship between polycystic ovary syndrome (PCOS) and ovarian cancer, and to present three hypotheses regarding hormonal factors and the risk of ovarian cancer in women. METHODS: Data were analyzed from a population-based, ... Full text Link to item Cite

Second-look operation for epithelial ovarian cancer: laparoscopy or laparotomy?

Journal Article Obstet Gynecol · October 1996 OBJECTIVES: To compare the results, complications, and hospital charges associated with laparoscopy versus laparotomy in second-look operations for epithelial ovarian cancer. METHODS: We conducted a retrospective chart review of 109 patients with invasive ... Full text Link to item Cite

Role of BRCA1 mutation screening in the management of familial ovarian cancer.

Journal Article Am J Obstet Gynecol · September 1996 Families with multiple cases of ovarian cancer have long been observed, and in the past prophylactic oophorectomy has been advocated for women with a history of ovarian cancer in two first-degree relatives. It is now thought that > 90% of familial ovarian ... Full text Link to item Cite

Role of BRCA1 mutation screening in the management of familial ovarian cancer

Journal Article AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY · September 1, 1996 Link to item Cite

Participation in a women's breast cancer risk counseling trial. Who participates? Who declines? High Risk Breast Cancer Consortium.

Journal Article Cancer · June 1, 1996 BACKGROUND: Little is known about what factors influence women to participate its trials designed for women at high risk for breast cancer. Yet the recruitment phase is of utmost importance in determining whether the trial can achieve its goals. The purpos ... Full text Link to item Cite

The genetic attributable risk of breast and ovarian cancer.

Journal Article Cancer · June 1, 1996 BACKGROUND: The age-specific proportion of breast and ovarian cancer in the general population that is likely to be due to a breast/ovarian cancer susceptibility gene(s) is estimated. In addition, the age-specific penetrance of ovarian cancer for women pre ... Full text Link to item Cite

No genetic effect of alpha1-antichymotrypsin in Alzheimer disease.

Journal Article Genomics · April 1, 1996 Alzheimer disease (AD) is the most common neurodegenerative disorder for individuals over the age of 40. AD has a complex etiology, and it is likely that multiple genes, acting independently and/or interacting, affect the risk of developing AD. Several gen ... Full text Link to item Cite

Age at diagnosis and multiple primary cancers of the breast and ovary.

Journal Article Breast Cancer Res Treat · 1996 This nested case-control study assessed the relationship between a woman's age at the time of her initial primary breast or ovarian cancer diagnosis and the risk of a second primary cancer at the other of these two sites. Multiple primary breast and ovaria ... Full text Link to item Cite

Loss of heterozygosity on chromosome 17q11-21 in cancers of women who have both breast and ovarian cancer.

Journal Article Am J Obstet Gynecol · March 1995 OBJECTIVE: Our purpose was to determine the frequency of allele loss in the region of the BRCA1 gene in cancers of women who have both breast and ovarian cancer. STUDY DESIGN: Four polymorphic microsatellite markers on chromosome 17q11-21 were examined by ... Full text Link to item Cite

Adherence to mammography among subgroups of women at high risk for breast cancer

Journal Article Journal of Women's Health · January 1, 1995 We present analyses comparing risk perception and screening behavior within subgroups of women at increased risk for breast cancer by virtue of family history and other epidemiologic risk factors. Subjects included 967 women over 35 years of age who were f ... Full text Cite

ANALYSIS OF THE GENETIC-RELATIONSHIP BETWEEN BREAST AND OVARIAN-CANCER

Journal Article AMERICAN JOURNAL OF HUMAN GENETICS · September 1, 1993 Link to item Cite

Family history of gynaecological cancers: relationships to the incidence of breast cancer prior to age 55.

Journal Article Int J Epidemiol · September 1991 As part of a multi-centre epidemiological study of cancer in women between the ages of 20 and 54, data were collected concerning family history of gynaecological cancers in the female relatives of 4730 women with newly diagnosed breast cancer and the relat ... Full text Link to item Cite

Oral contraceptives and breast cancer: a case-control study with hospital and community controls.

Journal Article Obstet Gynecol · September 1990 Several recent reports have noted an increase risk of breast cancer associated with the use of oral contraceptives (OCs) among various subgroups of young women. These reports spurred us to analyze data from a case-control study in North Carolina of 158 bre ... Link to item Cite

Oral contraceptives and breast cancer: A case-control study with hospital and community controls

Journal Article Obstetrics and Gynecology · January 1, 1990 Several recent reports have noted an increased risk of breast cancer associated with the use of oral contraceptives (OCs) among various subgroups of young women. These reports spurred us to analyze data from a case-control study in North Carolina of 158 br ... Cite

Evaluating genetic association among ovarian, breast, and endometrial cancer: evidence for a breast/ovarian cancer relationship.

Journal Article Am J Hum Genet · October 1989 The possibility of a genetic relationship between ovarian, breast, and endometrial cancer was investigated in data from a large multicenter, population-based, case-control study, the Cancer and Steroid Hormone Study conducted by the Centers for Disease Con ... Link to item Cite

Coronary risk associated with age and sex of parental heart disease in the Framingham Study.

Journal Article Am J Cardiol · September 15, 1989 Data from the Framingham Study, a population-based prospective study of 5,209 persons, were analyzed to determine whether a parental history of death by coronary artery disease (CAD) before or after 65 years of age was an independent risk factor for CAD of ... Full text Link to item Cite

The authors reply

Journal Article American Journal of Epidemiology · January 1, 1989 Full text Cite

Familial ovarian cancer: a population-based case-control study.

Journal Article Am J Epidemiol · September 1988 Data from a multicenter population-based case-control study were analyzed to assess the degree of aggregation of ovarian cancer in families. Included as cases were 493 women aged 20-54 who had been newly diagnosed with epithelial ovarian cancer. The freque ... Full text Link to item Cite

Relationship of epithelial ovarian cancer to other malignancies within families.

Journal Article Genet Epidemiol · 1988 The relationship of family history of cancer of the breast, colon/rectum, cervix, endometrium, lung, and thyroid to the risk of epithelial ovarian cancer was investigated in a large population-based case-control study. The data consisted of family historie ... Full text Link to item Cite