Scholars@Duke
G. Allan Johnson

G. Allan Johnson

Charles E. Putman University Distinguished Professor of Radiology
Radiology
gjohnson@duke.edu
Box 3302 Med Ctr, Durham, NC
141D Bryan Neuroscience Bldg, Research Drive, Durham, NC 27710
Office hours 8:30 AM-5:00 PM and by appointment.  
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Selected Publications

A prominent vertical occipital white matter fasciculus unique to primate brains.

Journal Article Curr Biol · August 19, 2024 Vision in humans and other primates enlists parallel processing streams in the dorsal and ventral visual cortex, known to support spatial and object processing, respectively. These streams are bridged, however, by a prominent white matter tract, the vertic ... Full text Link to item Cite

High-resolution diffusion magnetic resonance imaging and spatial-transcriptomic in developing mouse brain.

Journal Article Neuroimage · August 15, 2024 Brain development is a highly complex process regulated by numerous genes at the molecular and cellular levels. Brain tissue exhibits serial microstructural changes during the development process. High-resolution diffusion magnetic resonance imaging (dMRI) ... Full text Link to item Cite

Transcriptome analysis identifies an ASD-Like phenotype in oligodendrocytes and microglia from C58/J amygdala that is dependent on sex and sociability.

Journal Article Behav Brain Funct · June 19, 2024 BACKGROUND: Autism Spectrum Disorder (ASD) is a group of neurodevelopmental disorders with higher incidence in males and is characterized by atypical verbal/nonverbal communication, restricted interests that can be accompanied by repetitive behavior, and d ... Full text Link to item Cite

MR histology reveals tissue features beneath heterogeneous MRI signal in genetically engineered mouse models of sarcoma.

Journal Article Front Oncol · 2024 PURPOSE: To identify significant relationships between quantitative cytometric tissue features and quantitative MR (qMRI) intratumorally in preclinical undifferentiated pleomorphic sarcomas (UPS). MATERIALS AND METHODS: In a prospective study of geneticall ... Full text Link to item Cite

Merged magnetic resonance and light sheet microscopy of the whole mouse brain.

Journal Article Proc Natl Acad Sci U S A · April 25, 2023 We have developed workflows to align 3D magnetic resonance histology (MRH) of the mouse brain with light sheet microscopy (LSM) and 3D delineations of the same specimen. We start with MRH of the brain in the skull with gradient echo and diffusion tensor im ... Full text Link to item Cite

Prenatal heroin exposure alters brain morphology and connectivity in adolescent mice.

Journal Article NMR Biomed · February 2023 The United States is experiencing a dramatic increase in maternal opioid misuse and, consequently, the number of individuals exposed to opioids in utero. Prenatal opioid exposure has both acute and long-lasting effects on health and wellbeing. Effects on t ... Full text Link to item Cite

A rapid workflow for neuron counting in combined light sheet microscopy and magnetic resonance histology.

Journal Article Front Neurosci · 2023 Information on regional variation in cell numbers and densities in the CNS provides critical insight into structure, function, and the progression of CNS diseases. However, variability can be real or a consequence of methods that do not account for technic ... Full text Link to item Cite

Resolution and b value dependent structural connectome in ex vivo mouse brain.

Journal Article Neuroimage · July 15, 2022 Diffusion magnetic resonance imaging has been widely used in both clinical and preclinical studies to characterize tissue microstructure and structural connectivity. The diffusion MRI protocol for the Human Connectome Project (HCP) has been developed and o ... Full text Link to item Cite

A time-course study of actively stained mouse brains: Diffusion tensor imaging parameters and connectomic stability over 1 year.

Journal Article NMR Biomed · January 2022 While the application of diffusion tensor imaging (DTI), tractography, and connectomics to fixed tissue is a common practice today, there have been limited studies examining the effects of fixation on brain microstructure over extended periods. This mouse ... Full text Link to item Cite

Structural Connectivity of Human Inferior Colliculus Subdivisions Using in vivo and post mortem Diffusion MRI Tractography.

Journal Article Front Neurosci · 2022 Inferior colliculus (IC) is an obligatory station along the ascending auditory pathway that also has a high degree of top-down convergence via efferent pathways, making it a major computational hub. Animal models have attributed critical roles for the IC i ... Full text Link to item Cite

Tractography of Porcine Meniscus Microstructure Using High-Resolution Diffusion Magnetic Resonance Imaging.

Journal Article Front Endocrinol (Lausanne) · 2022 To noninvasively evaluate the three-dimensional collagen fiber architecture of porcine meniscus using diffusion MRI, meniscal specimens were scanned using a 3D diffusion-weighted spin-echo pulse sequence at 7.0 T. The collagen fiber alignment was revealed ... Full text Link to item Cite

Measuring Nonapoptotic Caspase Activity with a Transgenic Reporter in Mice.

Journal Article eNeuro · 2022 The protease caspase-3 is a key mediator of apoptotic programmed cell death. But weak or transient caspase activity can contribute to neuronal differentiation, axonal pathfinding, and synaptic long-term depression. Despite the importance of sublethal, or n ... Full text Link to item Cite

Volumetric analysis of the aging auditory pathway using high resolution magnetic resonance histology.

Journal Article Front Aging Neurosci · 2022 Numerous shown consequences of age-related hearing loss have been unveiled; however, the relationship of the cortical and subcortical structures of the auditory pathway with aging is not well known. Investigations into neural structure analysis remain spar ... Full text Link to item Cite

Restoring morphology of light sheet microscopy data based on magnetic resonance histology.

Journal Article Front Neurosci · 2022 The combination of cellular-resolution whole brain light sheet microscopy (LSM) images with an annotated atlas enables quantitation of cellular features in specific brain regions. However, most existing methods register LSM data with existing canonical atl ... Full text Link to item Cite

A multicontrast MR atlas of the Wistar rat brain.

Journal Article Neuroimage · November 15, 2021 We describe a multi-contrast, multi-dimensional atlas of the Wistar rat acquired at microscopic spatial resolution using magnetic resonance histology (MRH). Diffusion weighted images, and associated scalar images were acquired of a single specimen with a f ... Full text Link to item Cite

A high-resolution interactive atlas of the human brainstem using magnetic resonance imaging.

Journal Article Neuroimage · August 15, 2021 Conventional atlases of the human brainstem are limited by the inflexible, sparsely-sampled, two-dimensional nature of histology, or the low spatial resolution of conventional magnetic resonance imaging (MRI). Postmortem high-resolution MRI circumvents the ... Full text Link to item Cite

GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans.

Journal Article Nat Commun · August 12, 2021 Chronically elevated intraocular pressure (IOP) is the major risk factor of primary open-angle glaucoma, a leading cause of blindness. Dysfunction of the trabecular meshwork (TM), which controls the outflow of aqueous humor (AqH) from the anterior chamber, ... Full text Link to item Cite

Mapping the peripheral nervous system in the whole mouse via compressed sensing tractography.

Journal Article J Neural Eng · June 8, 2021 Objective.The peripheral nervous system (PNS) connects the central nervous system with the rest of the body to regulate many physiological functions and is therapeutically targeted to treat diseases such as epilepsy, depression, intestinal dysmotility, chr ... Full text Link to item Cite

Ex Vivo MR Histology and Cytometric Feature Mapping Connect Three-dimensional in Vivo MR Images to Two-dimensional Histopathologic Images of Murine Sarcomas.

Journal Article Radiol Imaging Cancer · May 2021 Purpose To establish a platform for quantitative tissue-based interpretation of cytoarchitecture features from tumor MRI measurements. Materials and Methods In a pilot preclinical study, multicontrast in vivo MRI of murine soft-tissue sarcomas in 10 mice, ... Full text Open Access Link to item Cite

A prominent vertical occipital white matter fasciculus unique to primate brains.

Journal Article Curr Biol · August 19, 2024 Vision in humans and other primates enlists parallel processing streams in the dorsal and ventral visual cortex, known to support spatial and object processing, respectively. These streams are bridged, however, by a prominent white matter tract, the vertic ... Full text Link to item Cite

High-resolution diffusion magnetic resonance imaging and spatial-transcriptomic in developing mouse brain.

Journal Article Neuroimage · August 15, 2024 Brain development is a highly complex process regulated by numerous genes at the molecular and cellular levels. Brain tissue exhibits serial microstructural changes during the development process. High-resolution diffusion magnetic resonance imaging (dMRI) ... Full text Link to item Cite

Transcriptome analysis identifies an ASD-Like phenotype in oligodendrocytes and microglia from C58/J amygdala that is dependent on sex and sociability.

Journal Article Behav Brain Funct · June 19, 2024 BACKGROUND: Autism Spectrum Disorder (ASD) is a group of neurodevelopmental disorders with higher incidence in males and is characterized by atypical verbal/nonverbal communication, restricted interests that can be accompanied by repetitive behavior, and d ... Full text Link to item Cite

MR histology reveals tissue features beneath heterogeneous MRI signal in genetically engineered mouse models of sarcoma.

Journal Article Front Oncol · 2024 PURPOSE: To identify significant relationships between quantitative cytometric tissue features and quantitative MR (qMRI) intratumorally in preclinical undifferentiated pleomorphic sarcomas (UPS). MATERIALS AND METHODS: In a prospective study of geneticall ... Full text Link to item Cite

Merged magnetic resonance and light sheet microscopy of the whole mouse brain.

Journal Article Proc Natl Acad Sci U S A · April 25, 2023 We have developed workflows to align 3D magnetic resonance histology (MRH) of the mouse brain with light sheet microscopy (LSM) and 3D delineations of the same specimen. We start with MRH of the brain in the skull with gradient echo and diffusion tensor im ... Full text Link to item Cite

Prenatal heroin exposure alters brain morphology and connectivity in adolescent mice.

Journal Article NMR Biomed · February 2023 The United States is experiencing a dramatic increase in maternal opioid misuse and, consequently, the number of individuals exposed to opioids in utero. Prenatal opioid exposure has both acute and long-lasting effects on health and wellbeing. Effects on t ... Full text Link to item Cite

A rapid workflow for neuron counting in combined light sheet microscopy and magnetic resonance histology.

Journal Article Front Neurosci · 2023 Information on regional variation in cell numbers and densities in the CNS provides critical insight into structure, function, and the progression of CNS diseases. However, variability can be real or a consequence of methods that do not account for technic ... Full text Link to item Cite

Resolution and b value dependent structural connectome in ex vivo mouse brain.

Journal Article Neuroimage · July 15, 2022 Diffusion magnetic resonance imaging has been widely used in both clinical and preclinical studies to characterize tissue microstructure and structural connectivity. The diffusion MRI protocol for the Human Connectome Project (HCP) has been developed and o ... Full text Link to item Cite

A time-course study of actively stained mouse brains: Diffusion tensor imaging parameters and connectomic stability over 1 year.

Journal Article NMR Biomed · January 2022 While the application of diffusion tensor imaging (DTI), tractography, and connectomics to fixed tissue is a common practice today, there have been limited studies examining the effects of fixation on brain microstructure over extended periods. This mouse ... Full text Link to item Cite

Structural Connectivity of Human Inferior Colliculus Subdivisions Using in vivo and post mortem Diffusion MRI Tractography.

Journal Article Front Neurosci · 2022 Inferior colliculus (IC) is an obligatory station along the ascending auditory pathway that also has a high degree of top-down convergence via efferent pathways, making it a major computational hub. Animal models have attributed critical roles for the IC i ... Full text Link to item Cite

Tractography of Porcine Meniscus Microstructure Using High-Resolution Diffusion Magnetic Resonance Imaging.

Journal Article Front Endocrinol (Lausanne) · 2022 To noninvasively evaluate the three-dimensional collagen fiber architecture of porcine meniscus using diffusion MRI, meniscal specimens were scanned using a 3D diffusion-weighted spin-echo pulse sequence at 7.0 T. The collagen fiber alignment was revealed ... Full text Link to item Cite

Measuring Nonapoptotic Caspase Activity with a Transgenic Reporter in Mice.

Journal Article eNeuro · 2022 The protease caspase-3 is a key mediator of apoptotic programmed cell death. But weak or transient caspase activity can contribute to neuronal differentiation, axonal pathfinding, and synaptic long-term depression. Despite the importance of sublethal, or n ... Full text Link to item Cite

Volumetric analysis of the aging auditory pathway using high resolution magnetic resonance histology.

Journal Article Front Aging Neurosci · 2022 Numerous shown consequences of age-related hearing loss have been unveiled; however, the relationship of the cortical and subcortical structures of the auditory pathway with aging is not well known. Investigations into neural structure analysis remain spar ... Full text Link to item Cite

Restoring morphology of light sheet microscopy data based on magnetic resonance histology.

Journal Article Front Neurosci · 2022 The combination of cellular-resolution whole brain light sheet microscopy (LSM) images with an annotated atlas enables quantitation of cellular features in specific brain regions. However, most existing methods register LSM data with existing canonical atl ... Full text Link to item Cite

A multicontrast MR atlas of the Wistar rat brain.

Journal Article Neuroimage · November 15, 2021 We describe a multi-contrast, multi-dimensional atlas of the Wistar rat acquired at microscopic spatial resolution using magnetic resonance histology (MRH). Diffusion weighted images, and associated scalar images were acquired of a single specimen with a f ... Full text Link to item Cite

A high-resolution interactive atlas of the human brainstem using magnetic resonance imaging.

Journal Article Neuroimage · August 15, 2021 Conventional atlases of the human brainstem are limited by the inflexible, sparsely-sampled, two-dimensional nature of histology, or the low spatial resolution of conventional magnetic resonance imaging (MRI). Postmortem high-resolution MRI circumvents the ... Full text Link to item Cite

GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans.

Journal Article Nat Commun · August 12, 2021 Chronically elevated intraocular pressure (IOP) is the major risk factor of primary open-angle glaucoma, a leading cause of blindness. Dysfunction of the trabecular meshwork (TM), which controls the outflow of aqueous humor (AqH) from the anterior chamber, ... Full text Link to item Cite

Mapping the peripheral nervous system in the whole mouse via compressed sensing tractography.

Journal Article J Neural Eng · June 8, 2021 Objective.The peripheral nervous system (PNS) connects the central nervous system with the rest of the body to regulate many physiological functions and is therapeutically targeted to treat diseases such as epilepsy, depression, intestinal dysmotility, chr ... Full text Link to item Cite

Ex Vivo MR Histology and Cytometric Feature Mapping Connect Three-dimensional in Vivo MR Images to Two-dimensional Histopathologic Images of Murine Sarcomas.

Journal Article Radiol Imaging Cancer · May 2021 Purpose To establish a platform for quantitative tissue-based interpretation of cytoarchitecture features from tumor MRI measurements. Materials and Methods In a pilot preclinical study, multicontrast in vivo MRI of murine soft-tissue sarcomas in 10 mice, ... Full text Open Access Link to item Cite

Microcephaly with altered cortical layering in GIT1 deficiency revealed by quantitative neuroimaging.

Journal Article Magn Reson Imaging · February 2021 G Protein-Coupled Receptor Kinase-Interacting Protein-1 (GIT1) regulates neuronal functions, including cell and axon migration and synapse formation and maintenance, and GIT1 knockout (KO) mice exhibit learning and memory deficits. We noted that male and f ... Full text Link to item Cite

Qualitative and Quantitative Neuropathology Approaches Using Magnetic Resonance Microscopy (Diffusion Tensor Imaging) and Stereology in a Hexachlorophene Model of Myelinopathy in Sprague-Dawley Rats.

Journal Article Toxicol Pathol · December 2020 It is well established that hexachlorophene, which is used as an antibacterial agent, causes intramyelinic edema in humans and animal models. The hexachlorophene myelinopathy model, in which male Sprague-Dawley rats received 25 to 30 mg/kg hexachlorophene ... Full text Link to item Cite

Variability and heritability of mouse brain structure: Microscopic MRI atlases and connectomes for diverse strains.

Journal Article Neuroimage · November 15, 2020 Genome-wide association studies have demonstrated significant links between human brain structure and common DNA variants. Similar studies with rodents have been challenging because of smaller brain volumes. Using high field MRI (9.4 T) and compressed sens ... Full text Link to item Cite

Characterization complex collagen fiber architecture in knee joint using high-resolution diffusion imaging.

Journal Article Magn Reson Med · August 2020 PURPOSE: To evaluate the complex fiber orientations and 3D collagen fiber network of knee joint connective tissues, including ligaments, muscle, articular cartilage, and meniscus using high spatial and angular resolution diffusion imaging. METHODS: Two rat ... Full text Open Access Link to item Cite

Cytoarchitecture of the mouse brain by high resolution diffusion magnetic resonance imaging.

Journal Article Neuroimage · August 1, 2020 MRI has been widely used to probe the neuroanatomy of the mouse brain, directly correlating MRI findings to histology is still challenging due to the limited spatial resolution and various image contrasts derived from water relaxation or diffusion properti ... Full text Link to item Cite

TBR-760, a Dopamine-Somatostatin Compound, Arrests Growth of Aggressive Nonfunctioning Pituitary Adenomas in Mice.

Journal Article Endocrinology · August 1, 2020 TBR-760 (formerly BIM-23A760) is a chimeric dopamine (DA)-somatostatin (SST) compound with potent agonist activity at both DA type 2 (D2R) and SST type 2 (SSTR2) receptors. Studies have shown that chimeric DA-SST compounds are more efficacious than individ ... Full text Link to item Cite

Optimizing Diffusion Imaging Protocols for Structural Connectomics in Mouse Models of Neurological Conditions.

Journal Article Front Phys · April 2020 Network approaches provide sensitive biomarkers for neurological conditions, such as Alzheimer's disease (AD). Mouse models can help advance our understanding of underlying pathologies, by dissecting vulnerable circuits. While the mouse brain contains less ... Full text Link to item Cite

MRI-Based Deep Learning Segmentation and Radiomics of Sarcoma in Mice.

Journal Article Tomography · March 2020 Small-animal imaging is an essential tool that provides noninvasive, longitudinal insight into novel cancer therapies. However, considerable variability in image analysis techniques can lead to inconsistent results. We have developed quantitative imaging f ... Full text Open Access Link to item Cite

3D Exploration of the Brainstem in 50-Micron Resolution MRI.

Journal Article Front Neuroanat · 2020 The brainstem, a structure of vital importance in mammals, is currently becoming a principal focus in cognitive, affective, and clinical neuroscience. Midbrain, pontine and medullary structures serve as the conduit for signals between the forebrain and spi ... Full text Link to item Cite

Whole mouse brain connectomics.

Journal Article J Comp Neurol · September 1, 2019 Methods have been developed to allow quantitative connectivity of the whole fixed mouse brain by means of magnetic resonance imaging (MRI). We have translated what we have learned in clinical imaging to the very special domain of the mouse brain. Diffusion ... Full text Link to item Cite

Structural mapping with fiber tractography of the human cuneate fasciculus at microscopic resolution in cervical region.

Journal Article Neuroimage · August 1, 2019 Human spinal white matter tract anatomy has been mapped using post mortem histological information with the help of molecular tracing studies in animal models. This study used 7 Tesla diffusion MR tractography on a human cadaver that was harvested 24 hours ... Full text Link to item Cite

Mapping the human subcortical auditory system using histology, postmortem MRI and in vivo MRI at 7T.

Journal Article Elife · August 1, 2019 Studying the human subcortical auditory system non-invasively is challenging due to its small, densely packed structures deep within the brain. Additionally, the elaborate three-dimensional (3-D) structure of the system can be difficult to understand based ... Full text Link to item Cite

Small Animal Multivariate Brain Analysis (SAMBA) - a High Throughput Pipeline with a Validation Framework.

Journal Article Neuroinformatics · July 2019 While many neuroscience questions aim to understand the human brain, much current knowledge has been gained using animal models, which replicate genetic, structural, and connectivity aspects of the human brain. While voxel-based analysis (VBA) of preclinic ... Full text Link to item Cite

Diffusion tractography of the rat knee at microscopic resolution.

Journal Article Magn Reson Med · June 2019 PURPOSE: To evaluate whole knee joint tractography, including articular cartilage, ligaments, meniscus, and growth plate using diffusion tensor imaging (DTI) at microscopic resolution. METHODS: Three rat knee joints were scanned using a modified 3D diffusi ... Full text Link to item Cite

Neurite orientation dispersion and density imaging of mouse brain microstructure.

Journal Article Brain Struct Funct · June 2019 Advanced biophysical models like neurite orientation dispersion and density imaging (NODDI) have been developed to estimate the microstructural complexity of voxels enriched in dendrites and axons for both in vivo and ex vivo studies. NODDI metrics derived ... Full text Link to item Cite

Dynamic contrast-enhanced MRI promotes early detection of toxin-induced acute kidney injury.

Journal Article Am J Physiol Renal Physiol · February 1, 2019 Acute kidney injury (AKI) is a common cause of morbidity and mortality in hospitalized patients. Nevertheless, there is limited ability to diagnose AKI in its earliest stages through the collection of structural and functional information. Magnetic resonan ... Full text Link to item Cite

Bridging the translational gap: Implementation of multimodal small animal imaging strategies for tumor burden assessment in a co-clinical trial.

Journal Article PLoS One · 2019 In designing co-clinical cancer studies, preclinical imaging brings unique challenges that emphasize the gap between man and mouse. Our group is developing quantitative imaging methods for the preclinical arm of a co-clinical trial studying immunotherapy a ... Full text Open Access Link to item Cite

Identifying Vulnerable Brain Networks in Mouse Models of Genetic Risk Factors for Late Onset Alzheimer's Disease.

Journal Article Front Neuroinform · 2019 The major genetic risk for late onset Alzheimer's disease has been associated with the presence of APOE4 alleles. However, the impact of different APOE alleles on the brain aging trajectory, and how they interact with the brain local environment in a sex s ... Full text Link to item Cite

Accelerating quantitative susceptibility imaging acquisition using compressed sensing.

Journal Article Phys Med Biol · December 10, 2018 To evaluate the feasibility of compressed sensing (CS) for accelerating quantitative susceptibility mapping (QSM) acquisition in MR histology, control, demyelination, and remyelination mice were scanned using a modified 3D gradient echo (GRE) pulse sequenc ... Full text Link to item Cite

Whole mouse brain structural connectomics using magnetic resonance histology.

Journal Article Brain Struct Funct · December 2018 Diffusion tensor histology holds great promise for quantitative characterization of structural connectivity in mouse models of neurological and psychiatric conditions. There has been extensive study in both the clinical and preclinical domains on the compl ... Full text Link to item Cite

Diffusion tensor imaging using multiple coils for mouse brain connectomics.

Journal Article NMR Biomed · June 2018 The correlation between brain connectivity and psychiatric or neurological diseases has intensified efforts to develop brain connectivity mapping techniques on mouse models of human disease. The neural architecture of mouse brain specimens can be shown non ... Full text Link to item Cite

Postmortem diffusion MRI of the entire human spinal cord at microscopic resolution.

Journal Article Neuroimage Clin · 2018 The human spinal cord is a central nervous system structure that plays an important role in normal motor and sensory function, and can be affected by many debilitating neurologic diseases. Due to its clinical importance, the spinal cord is frequently the s ... Full text Link to item Cite

Susceptibility tensor imaging and tractography of collagen fibrils in the articular cartilage.

Journal Article Magn Reson Med · November 2017 PURPOSE: To investigate the B0 orientation-dependent magnetic susceptibility of collagen fibrils within the articular cartilage and to determine whether susceptibility tensor imaging (STI) can detect the 3D collagen network within cartilage. METHODS: Multi ... Full text Link to item Cite

Adult rat cortical thickness changes across age and following adolescent intermittent ethanol treatment.

Journal Article Addict Biol · May 2017 Human studies have established that adolescence is a period of brain maturation that parallels the development of adult behaviors. However, little is known regarding cortical development in the adult rat brain. We used magnetic resonance imaging (MRI) and ... Full text Link to item Cite

MRI tools for assessment of microstructure and nephron function of the kidney.

Journal Article Am J Physiol Renal Physiol · December 1, 2016 MRI can provide excellent detail of renal structure and function. Recently, novel MR contrast mechanisms and imaging tools have been developed to evaluate microscopic kidney structures including the tubules and glomeruli. Quantitative MRI can assess local ... Full text Open Access Link to item Cite

Imaging whole-brain cytoarchitecture of mouse with MRI-based quantitative susceptibility mapping.

Journal Article Neuroimage · August 15, 2016 The proper microstructural arrangement of complex neural structures is essential for establishing the functional circuitry of the brain. We present an MRI method to resolve tissue microstructure and infer brain cytoarchitecture by mapping the magnetic susc ... Full text Link to item Cite

Dynamic contrast-enhanced quantitative susceptibility mapping with ultrashort echo time MRI for evaluating renal function.

Journal Article Am J Physiol Renal Physiol · January 15, 2016 Dynamic contrast-enhanced (DCE) MRI can provide key insight into renal function. DCE MRI is typically achieved through an injection of a gadolinium (Gd)-based contrast agent, which has desirable T1 quenching and tracer kinetics. However, significant T2* bl ... Full text Link to item Cite

Tumor location, but not H3.3K27M, significantly influences the blood-brain-barrier permeability in a genetic mouse model of pediatric high-grade glioma.

Journal Article J Neurooncol · January 2016 Pediatric high-grade gliomas (pHGGs) occur with strikingly different frequencies in infratentorial and supratentorial regions. Although histologically these malignancies appear similar, they represent distinct diseases. Recent genomic studies have identifi ... Full text Link to item Cite

Image-processing pipelines: Applications in magnetic resonance histology

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2016 Image processing has become ubiquitous in imaging research - so ubiquitous that it is easy to loose track of how diverse this processing has become. The Duke Center for In Vivo Microscopy has pioneered the development of Magnetic Resonance Histology (MRH), ... Full text Cite

A Diffusion MRI Tractography Connectome of the Mouse Brain and Comparison with Neuronal Tracer Data.

Journal Article Cereb Cortex · November 2015 Featured Publication Interest in structural brain connectivity has grown with the understanding that abnormal neural connections may play a role in neurologic and psychiatric diseases. Small animal connectivity mapping techniques are particularly important for identifying aber ... Full text Open Access Link to item Cite

Use of magnetic resonance imaging in the study of plants and soils

Conference · October 26, 2015 The nondestructive study of plants and soils in situ has historically been difficult due to the inherently opaque nature of the system. Repeated study of root growth and physiological processes in bulk soil has been impossible without techniques for remote ... Full text Cite

A diffusion tensor MRI atlas of the postmortem rhesus macaque brain.

Journal Article Neuroimage · August 15, 2015 Featured Publication The rhesus macaque (Macaca mulatta) is the most widely used nonhuman primate for modeling the structure and function of the brain. Brain atlases, and particularly those based on magnetic resonance imaging (MRI), have become important tools for understandin ... Full text Link to item Cite

Postmortem diffusion MRI of the human brainstem and thalamus for deep brain stimulator electrode localization.

Journal Article Hum Brain Mapp · August 2015 Featured Publication Deep brain stimulation (DBS) is an established surgical therapy for medically refractory tremor disorders including essential tremor (ET) and is currently under investigation for use in a variety of other neurologic and psychiatric disorders. There is grow ... Full text Link to item Cite

Magnetic resonance histology.

Journal Article J Magn Reson Imaging · July 2015 Featured Publication Full text Link to item Cite

An MRI/DTI Atlas of the Rat Brain

Book · May 28, 2015 Featured Publication MRI/DTI Atlas of the Rat Brain offers two major enhancements when compared with earlier attempts to make MRI/DTI rat brain atlases. First, the spatial resolution at 25μm is considerably higher than previous data published. Secondly, the comprehensive set o ... Cite

4D MRI of polycystic kidneys from rapamycin-treated Glis3-deficient mice.

Journal Article NMR Biomed · May 2015 Featured Publication Polycystic kidney disease (PKD) is a life-threatening disease that leads to a grotesque enlargement of the kidney and significant loss of function. Several imaging studies with MRI have demonstrated that cyst size in polycystic kidneys can determine diseas ... Full text Link to item Cite

Dynamic contrast-enhanced MR microscopy identifies regions of therapeutic response in a preclinical model of colorectal adenocarcinoma.

Journal Article Med Phys · May 2015 Featured Publication PURPOSE: A typical dynamic contrast-enhanced (DCE)-MRI study often compares the derived pharmacokinetic parameters on manually selected tumor regions or over the entire tumor volume. These measurements include domains where the interpretation of the biomar ... Full text Link to item Cite

Susceptibility tensor imaging of the kidney and its microstructural underpinnings.

Journal Article Magn Reson Med · March 2015 Featured Publication PURPOSE: The purpose of this study was to determine whether susceptibility tensor imaging (STI) could overcome limitations of current techniques to detect tubules throughout the kidney. METHODS: Normal mouse kidneys (n = 4) were imaged at 9.4T using a thre ... Full text Link to item Cite

Addendum to “Waxholm Space atlas of the Sprague Dawley rat brain” [NeuroImage 97 (2014) 374-386].

Journal Article Neuroimage · January 15, 2015 Featured Publication The main focus of our original article was to describe the anatomical delineations constituting the first version of the WHS Sprague Dawley atlas, apply the Waxholm Space coordinate system, and publish the associated MRI/DTI template and segmentation volum ... Full text Link to item Cite

Localization of Metal Electrodes in the Intact Rat Brain Using Registration of 3D Microcomputed Tomography Images to a Magnetic Resonance Histology Atlas.

Journal Article eNeuro · 2015 Featured Publication Simultaneous neural recordings taken from multiple areas of the rodent brain are garnering growing interest due to the insight they can provide about spatially distributed neural circuitry. The promise of such recordings has inspired great progress in meth ... Full text Open Access Link to item Cite

Prenatal alcohol exposure reduces magnetic susceptibility contrast and anisotropy in the white matter of mouse brains.

Journal Article Neuroimage · November 15, 2014 Prenatal alcohol exposure can result in long-term cognitive and behavioral deficits. Fetal alcohol spectrum disorder (FASD) refers to a range of permanent birth defects caused by prenatal alcohol exposure, and is the most common neurodevelopmental disorder ... Full text Link to item Cite

Investigating the tradeoffs between spatial resolution and diffusion sampling for brain mapping with diffusion tractography: time well spent?

Journal Article Hum Brain Mapp · November 2014 Featured Publication Interest in mapping white matter pathways in the brain has peaked with the recognition that altered brain connectivity may contribute to a variety of neurologic and psychiatric diseases. Diffusion tractography has emerged as a popular method for postmortem ... Full text Link to item Cite

A high-resolution cardiovascular magnetic resonance diffusion tensor map from ex-vivo C57BL/6 murine hearts.

Journal Article J Cardiovasc Magn Reson · October 16, 2014 BACKGROUND: The complex cardiac fiber structural organization and spatial arrangement of cardiomyocytes in laminar sheetlets contributes greatly to cardiac functional and contractile ejection patterns. This study presents the first comprehensive, ultra-hig ... Full text Link to item Cite

Four-dimensional MRI of renal function in the developing mouse.

Journal Article NMR Biomed · September 2014 Featured Publication The major roles of filtration, metabolism and high blood flow make the kidney highly vulnerable to drug-induced toxicity and other renal injuries. A method to follow kidney function is essential for the early screening of toxicity and malformations. In thi ... Full text Link to item Cite

Magnetic resonance histology—Applications in toxicology

Conference Toxicology Letters · September 2014 Featured Publication Full text Cite

Waxholm Space atlas of the Sprague Dawley rat brain.

Journal Article Neuroimage · August 15, 2014 Featured Publication Three-dimensional digital brain atlases represent an important new generation of neuroinformatics tools for understanding complex brain anatomy, assigning location to experimental data, and planning of experiments. We have acquired a microscopic resolution ... Full text Link to item Cite

Helical dual source cone-beam micro-CT

Conference 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014 · July 29, 2014 While helical scanning is well established in the clinical arena, most micro-CT scanners use circular cone beam trajectories and approximate reconstructions based on a filtered backprojection (FBP) algorithm. This may be sufficient for some applications, b ... Full text Cite

Diffusion tensor imaging reveals white matter injury in a rat model of repetitive blast-induced traumatic brain injury.

Journal Article J Neurotrauma · May 15, 2014 Featured Publication Blast-induced traumatic brain injury (bTBI) is one of the most common combat-related injuries seen in U.S. military personnel, yet relatively little is known about the underlying mechanisms of injury. In particular, the effects of the primary blast pressur ... Full text Link to item Cite

Quantitative mapping of trimethyltin injury in the rat brain using magnetic resonance histology.

Journal Article Neurotoxicology · May 2014 Featured Publication The growing exposure to chemicals in our environment and the increasing concern over their impact on health have elevated the need for new methods for surveying the detrimental effects of these compounds. Today's gold standard for assessing the effects of ... Full text Open Access Link to item Cite

Comparison of 4D-microSPECT and microCT for murine cardiac function.

Journal Article Mol Imaging Biol · April 2014 PURPOSE: The objective of this study was to compare a new generation of four-dimensional micro-single photon emission computed tomography (microSPECT) with microCT for the quantitative in vivo assessment of murine cardiac function. PROCEDURES: Four-dimensi ... Full text Link to item Cite

Quantitative magnetic susceptibility of the developing mouse brain reveals microstructural changes in the white matter.

Journal Article Neuroimage · March 2014 Cerebral development involves a complex cascade of events which are difficult to visualize and quantify in vivo. In this study we combine information from Diffusion Tensor Imaging (DTI) and Quantitative Susceptibility Mapping (QSM) to analyze developing mo ... Full text Link to item Cite

Assessing cardiac injury in mice with dual energy-microCT, 4D-microCT, and microSPECT imaging after partial heart irradiation.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2014 PURPOSE: To develop a mouse model of cardiac injury after partial heart irradiation (PHI) and to test whether dual energy (DE)-microCT and 4-dimensional (4D)-microCT can be used to assess cardiac injury after PHI to complement myocardial perfusion imaging ... Full text Open Access Link to item Cite

An analysis of the uncertainty and bias in DCE-MRI measurements using the spoiled gradient-recalled echo pulse sequence.

Journal Article Med Phys · March 2014 PURPOSE: The pharmacokinetic parameters derived from dynamic contrast-enhanced (DCE) MRI have been used in more than 100 phase I trials and investigator led studies. A comparison of the absolute values of these quantities requires an estimation of their re ... Full text Link to item Cite

Semi-automated 3D segmentation of major tracts in the rat brain: comparing DTI with standard histological methods.

Journal Article Brain Struct Funct · March 2014 Featured Publication Researchers working with rodent models of neurological disease often require an accurate map of the anatomical organization of the white matter of the rodent brain. With the increasing popularity of small animal MRI techniques, including diffusion tensor i ... Full text Link to item Cite

Anatomical and functional imaging of myocardial infarction in mice using micro-CT and eXIA 160 contrast agent.

Journal Article Contrast Media Mol Imaging · 2014 Noninvasive small animal imaging techniques are essential for evaluation of cardiac disease and potential therapeutics. A novel preclinical iodinated contrast agent called eXIA 160 has recently been developed, which has been evaluated for micro-CT cardiac ... Full text Link to item Cite

A multi-resolution approach to retrospectively-gated cardiac micro-CT reconstruction

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2014 In preclinical research, micro-CT is commonly used to provide anatomical information; however, there is significant interest in using this technology to obtain functional information in cardiac studies. The fastest acquisition in 4D cardiac micro-CT imagin ... Full text Cite

Robust material decomposition for spectral CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2014 There is ongoing interest in extending CT from anatomical to functional imaging. Recent successes with dual energy CT, the introduction of energy discriminating x-ray detectors, and novel, target-specific, nanoparticle contrast agents enable functional ima ... Full text Cite

Dual-energy micro-CT imaging of pulmonary airway obstruction: Correlation with micro-SPECT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2014 To match recent clinical dual energy (DE) CT studies focusing on the lung, similar developments for DE micro-CT of the rodent lung are required. Our group has been actively engaged in designing pulmonary gating techniques for micro- CT, and has also introd ... Full text Cite

Characterization of subtle brain abnormalities in a mouse model of Hedgehog pathway antagonist-induced cleft lip and palate.

Journal Article PLoS One · 2014 Subtle behavioral and cognitive deficits have been documented in patient cohorts with orofacial clefts (OFCs). Recent neuroimaging studies argue that these traits are associated with structural brain abnormalities but have been limited to adolescent and ad ... Full text Open Access Link to item Cite

Magnetic resonance imaging of graded skeletal muscle injury in live rats.

Journal Article Environ Health Insights · 2014 INTRODUCTION: Increasing number of stretch-shortening contractions (SSCs) results in increased muscle injury. METHODS: Fischer Hybrid rats were acutely exposed to an increasing number of SSCs in vivo using a custom-designed dynamometer. Magnetic resonance ... Full text Open Access Link to item Cite

Quantitative susceptibility mapping of kidney inflammation and fibrosis in type 1 angiotensin receptor-deficient mice.

Journal Article NMR Biomed · December 2013 Disruption of the regulatory role of the kidneys leads to diverse renal pathologies; one major hallmark is inflammation and fibrosis. Conventional magnitude MRI has been used to study renal pathologies; however, the quantification or even detection of foca ... Full text Link to item Cite

Diffusion tensor magnetic resonance histology reveals microstructural changes in the developing rat brain.

Journal Article Neuroimage · October 1, 2013 Featured Publication The postnatal period is a remarkably dynamic phase of brain growth and development characterized by large-scale macrostructural changes, as well as dramatic microstructural changes, including myelination and cortical layering. This crucial period of neurod ... Full text Link to item Cite

Constructing a 4D murine cardiac micro-CT atlas for automated segmentation and phenotyping applications

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · June 3, 2013 A number of investigators have demonstrated the potential of preclinical micro-CT in characterizing cardiovascular disease in mouse models. One major hurdle to advancing this approach is the extensive user interaction required to derive quantitative metric ... Full text Cite

The effect of scatter correction on dual energy micro-CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · June 3, 2013 Dual energy (DE) CT imaging is expected to play a major role in the diagnostic arena as it provides a quantitative decomposition of basis materials, opening the door for new clinical applications without significantly increasing dose to the patient. DE-CT ... Full text Cite

Altered diffusion tensor imaging measurements in aged transgenic Huntington disease rats.

Journal Article Brain Struct Funct · May 2013 Rodent models of Huntington disease (HD) are valuable tools for investigating HD pathophysiology and evaluating new therapeutic approaches. Non-invasive characterization of HD-related phenotype changes is important for monitoring progression of pathologica ... Full text Open Access Link to item Cite

A quantitative magnetic resonance histology atlas of postnatal rat brain development with regional estimates of growth and variability.

Journal Article Neuroimage · May 1, 2013 There has been growing interest in the role of postnatal brain development in the etiology of several neurologic diseases. The rat has long been recognized as a powerful model system for studying neuropathology and the safety of pharmacologic treatments. H ... Full text Link to item Cite

Dual-energy micro-computed tomography imaging of radiation-induced vascular changes in primary mouse sarcomas.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2013 PURPOSE: To evaluate the effects of radiation therapy on primary tumor vasculature using dual-energy (DE) micro-computed tomography (micro-CT). METHODS AND MATERIALS: Primary sarcomas were generated with mutant Kras and p53. Unirradiated tumors were compar ... Full text Link to item Cite

The utility of micro-CT and MRI in the assessment of longitudinal growth of liver metastases in a preclinical model of colon carcinoma.

Journal Article Acad Radiol · April 2013 Featured Publication RATIONALE AND OBJECTIVES: Liver is a common site for distal metastases in colon and rectal cancer. Numerous clinical studies have analyzed the relative merits of different imaging modalities for detection of liver metastases. Several exciting new therapies ... Full text Link to item Cite

Dual-energy computed tomography imaging of atherosclerotic plaques in a mouse model using a liposomal-iodine nanoparticle contrast agent.

Journal Article Circ Cardiovasc Imaging · March 1, 2013 BACKGROUND: The accumulation of macrophages in inflamed atherosclerotic plaques has long been recognized. In an attempt to develop an imaging agent for detection of vulnerable plaques, we evaluated the feasibility of a liposomal-iodine nanoparticle contras ... Full text Link to item Cite

An ontology-based segmentation scheme for tracking postnatal changes in the developing rodent brain with MRI.

Journal Article Neuroimage · February 15, 2013 Featured Publication The postnatal period of neurodevelopment has been implicated in a number of brain disorders including autism and schizophrenia. Rodent models have proven to be invaluable in advancing our understanding of the human brain, and will almost certainly play a p ... Full text Link to item Cite

A comparison of radial keyhole strategies for high spatial and temporal resolution 4D contrast-enhanced MRI in small animal tumor models.

Journal Article Med Phys · February 2013 Featured Publication PURPOSE: Dynamic contrast-enhanced (DCE) MRI has been widely used as a quantitative imaging method for monitoring tumor response to therapy. The simultaneous challenges of increasing temporal and spatial resolution in a setting where the signal from the mu ... Full text Link to item Cite

A LabVIEW Platform for Preclinical Imaging Using Digital Subtraction Angiography and Micro-CT.

Journal Article J Med Eng · 2013 CT and digital subtraction angiography (DSA) are ubiquitous in the clinic. Their preclinical equivalents are valuable imaging methods for studying disease models and treatment. We have developed a dual source/detector X-ray imaging system that we have used ... Full text Open Access Link to item Cite

Magnetic resonance microscopy.

Journal Article Stud Health Technol Inform · 2013 Featured Publication MRI, one of the major clinical imaging modalities, has gained an important role in studying small animal models, e.g., rats and mice. But imaging rodents comes with challenges, since the image resolution needs to be ~ 3000-times higher to resolve anatomica ... Link to item Cite

Altered diffusion tensor imaging measurements in aged transgenic Huntington disease rats

Journal Article Brain Structure and Function · 2013 Rodent models of Huntington disease (HD) are valuable tools for investigating HD pathophysiology and evaluating new therapeutic approaches. Non-invasive characterization of HD-related phenotype changes is important for monitoring progression of pathologica ... Full text Cite

Magnetic resonance histology: cool images- but who cares?

Journal Article TOXICOLOGY LETTERS · 2013 Featured Publication Full text Cite

Magnetic resonance microscopy-based analyses of the neuroanatomical effects of gestational day 9 ethanol exposure in mice.

Journal Article Neurotoxicol Teratol · 2013 Animal model-based studies have shown that ethanol exposure during early gestation induces developmental stage-specific abnormalities of the face and brain. The exposure time-dependent variability in ethanol's teratogenic outcomes is expected to contribute ... Full text Link to item Cite

Quantitative mouse brain phenotyping based on single and multispectral MR protocols.

Journal Article Neuroimage · November 15, 2012 Featured Publication Sophisticated image analysis methods have been developed for the human brain, but such tools still need to be adapted and optimized for quantitative small animal imaging. We propose a framework for quantitative anatomical phenotyping in mouse models of neu ... Full text Link to item Cite

Functional neuroimaging using ultrasonic blood-brain barrier disruption and manganese-enhanced MRI.

Journal Article Journal of visualized experiments : JoVE · October 23, 2012 Although mice are the dominant model system for studying the genetic and molecular underpinnings of neuroscience, functional neuroimaging in mice remains technically challenging. One approach, Activation-Induced Manganese-enhanced MRI (AIM MRI), has been u ... Cite

Registration-based segmentation of murine 4D cardiac micro-CT data using symmetric normalization.

Journal Article Phys Med Biol · October 7, 2012 Micro-CT can play an important role in preclinical studies of cardiovascular disease because of its high spatial and temporal resolution. Quantitative analysis of 4D cardiac images requires segmentation of the cardiac chambers at each time point, an extrem ... Full text Link to item Cite

A multidimensional magnetic resonance histology atlas of the Wistar rat brain.

Journal Article Neuroimage · September 2012 Featured Publication We have produced a multidimensional atlas of the adult Wistar rat brain based on magnetic resonance histology (MRH). This MR atlas has been carefully aligned with the widely used Paxinos-Watson atlas based on optical sections to allow comparisons between h ... Full text Link to item Cite

Temporal and spectral imaging with micro-CT.

Journal Article Med Phys · August 2012 PURPOSE: Micro-CT is widely used for small animal imaging in preclinical studies of cardiopulmonary disease, but further development is needed to improve spatial resolution, temporal resolution, and material contrast. We present a technique for visualizing ... Full text Link to item Cite

Functional neuroimaging using ultrasonic blood-brain barrier disruption and manganese-enhanced MRI.

Journal Article J Vis Exp · July 12, 2012 Although mice are the dominant model system for studying the genetic and molecular underpinnings of neuroscience, functional neuroimaging in mice remains technically challenging. One approach, Activation-Induced Manganese-enhanced MRI (AIM MRI), has been u ... Full text Link to item Cite

Magnetic resonance histology of age-related nephropathy in the Sprague Dawley rat.

Journal Article Toxicol Pathol · July 2012 Magnetic resonance histology (MRH) has become a valuable tool in evaluating drug-induced toxicity in preclinical models. However, its application in renal injury has been limited. This study tested the hypothesis that MRH could detect image-based biomarker ... Full text Link to item Cite

A comparison of sampling strategies for dual energy micro-CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · May 4, 2012 Micro-CT has become a powerful tool for small animal research. Many micro-CT applications require exogenous contrast agents, which are most commonly based on iodine. Despite advancements in contrast agents, single-energy micro-CT is sometimes limited in th ... Full text Cite

Morphological studies of the murine heart based on probabilistic and statistical atlases.

Journal Article Comput Med Imaging Graph · March 2012 This study directly compares morphological features of the mouse heart in its end-relaxed state based on constructed morphometric maps and atlases using principal component analysis in C57BL/6J (n=8) and DBA (n=5) mice. In probabilistic atlases, a gradient ... Full text Link to item Cite

Denoising of 4D Cardiac Micro-CT Data Using Median-Centric Bilateral Filtration.

Conference Proc SPIE Int Soc Opt Eng · February 23, 2012 Bilateral filtration has proven an effective tool for denoising CT data. The classic filter utilizes Gaussian domain and range weighting functions in 2D. More recently, other distributions have yielded more accurate results in specific applications, and th ... Full text Link to item Cite

3D fiber tractography with susceptibility tensor imaging.

Journal Article Neuroimage · January 16, 2012 Featured Publication Gradient-echo MRI has revealed anisotropic magnetic susceptibility in the brain white matter. This magnetic susceptibility anisotropy can be measured and characterized with susceptibility tensor imaging (STI). In this study, a method of fiber tractography ... Full text Link to item Cite

4D micro-CT using fast prospective gating.

Journal Article Phys Med Biol · January 7, 2012 Featured Publication Micro-CT is currently used in preclinical studies to provide anatomical information. But, there is also significant interest in using this technology to obtain functional information. We report here a new sampling strategy for 4D micro-CT for functional ca ... Full text Link to item Cite

Plants, seeds, roots, and soils as applications of magnetic resonance microscopy

Journal Article eMagRes · January 1, 2012 High-resolution magnetic resonance microscopy is discussed as a useful tool in the study of plant structure and physiology. In contrast to animals, plants have a relatively homogenous distribution of water throughout the tissues. High quality images highli ... Full text Cite

Magnetic resonance microscopy

Chapter · January 1, 2012 Visualization of internal structures of opaque biologic objects is essential in many biomedical studies. Limited by the penetration depth of the probing sources (photons and electrons) and the lack of endogenous contrast, conventional forms of microscopy s ... Full text Cite

Computed tomography imaging of primary lung cancer in mice using a liposomal-iodinated contrast agent.

Journal Article PLoS One · 2012 PURPOSE: To investigate the utility of a liposomal-iodinated nanoparticle contrast agent and computed tomography (CT) imaging for characterization of primary nodules in genetically engineered mouse models of non-small cell lung cancer. METHODS: Primary lun ... Full text Open Access Link to item Cite

Magnetic resonance microscopy.

Journal Article Anal Cell Pathol (Amst) · 2012 Featured Publication Full text Open Access Link to item Cite

Investigations on X-ray luminescence CT for small animal imaging.

Conference Proc SPIE Int Soc Opt Eng · 2012 X-ray Luminescence CT (XLCT) is a hybrid imaging modality combining x-ray and optical imaging in which x-ray luminescent nanophosphors (NPs) are used as emissive imaging probes. NPs are easily excited using common CT energy x-ray beams, and the NP luminesc ... Full text Link to item Cite

Ethanol-induced face-brain dysmorphology patterns are correlative and exposure-stage dependent.

Journal Article PLoS One · 2012 Featured Publication Prenatal ethanol exposure is the leading preventable cause of congenital mental disability. Whereas a diagnosis of fetal alcohol syndrome (FAS) requires identification of a specific pattern of craniofacial dysmorphology, most individuals with behavioral an ... Full text Link to item Cite

Population-averaged diffusion tensor imaging atlas of the Sprague Dawley rat brain.

Journal Article Neuroimage · October 15, 2011 Featured Publication Rats are widely used in experimental neurobiological research, and rat brain atlases are important resources for identifying brain regions in the context of experimental microsurgery, tissue sampling, and neuroimaging, as well as comparison of findings acr ... Full text Link to item Cite

High-resolution reconstruction of fluorescent inclusions in mouse thorax using anatomically guided sampling and parallel Monte Carlo computing.

Journal Article Biomed Opt Express · September 1, 2011 We present a method for high-resolution reconstruction of fluorescent images of the mouse thorax. It features an anatomically guided sampling method to retrospectively eliminate problematic data and a parallel Monte Carlo software package to compute the Ja ... Full text Open Access Link to item Cite

4D micro-CT for cardiac and perfusion applications with view under sampling.

Journal Article Phys Med Biol · June 7, 2011 Micro-CT is commonly used in preclinical studies to provide anatomical information. There is growing interest in obtaining functional measurements from 4D micro-CT. We report here strategies for 4D micro-CT with a focus on two applications: (i) cardiac ima ... Full text Link to item Cite

High-field (9.4 T) MRI of brain dysmyelination by quantitative mapping of magnetic susceptibility.

Journal Article Neuroimage · June 1, 2011 Featured Publication The multilayered myelin sheath wrapping around nerve axons is essential for proper functioning of the central nervous system. Abnormal myelination leads to a wide range of neurological diseases and developmental disorders. Non-invasive imaging of myelin co ... Full text Link to item Cite

Microscopic diffusion tensor atlas of the mouse brain.

Journal Article Neuroimage · June 1, 2011 Eight diffusion tensor imaging (DTI) datasets of normal adult C57BL/6J mouse brains were acquired with an isotropic Nyquist limited resolution of 43 μm (voxel volume ~80 pl). Each specimen was scanned with a b0 image and 6 diffusion-weighted images. T1- an ... Full text Link to item Cite

Dual-energy micro-CT imaging for differentiation of iodine- and gold-based nanoparticles

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · May 13, 2011 Spectral CT imaging is expected to play a major role in the diagnostic arena as it provides material decomposition on an elemental basis. One fascinating possibility is the ability to discriminate multiple contrast agents targeting different biological sit ... Full text Cite

A symmetrical Waxholm canonical mouse brain for NeuroMaps.

Journal Article J Neurosci Methods · February 15, 2011 Featured Publication NeuroMaps (2010) is a Web-based application that enables investigators to map data from macaque studies to a canonical atlas of the macaque brain. It currently serves as an image processor enabling them to create figures suitable for publication, presentat ... Full text Link to item Cite

Digital atlasing and standardization in the mouse brain.

Journal Article PLoS Comput Biol · February 3, 2011 Featured Publication Full text Link to item Cite

Reduction of artifacts in T2 -weighted PROPELLER in high-field preclinical imaging.

Journal Article Magn Reson Med · February 2011 A simple technique is implemented for correction of artifacts arising from nonuniform T(2) -weighting of k-space data in fast spin echo-based PROPELLER (periodically rotated overlapping parallel lines with enhanced reconstruction). An additional blade with ... Full text Link to item Cite

MAGNETIC RESONANCE MICROSCOPY-BASED 3D FACE-BRAIN CORRELATIONS IN AN FASD MOUSE MODEL

Conference ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH · 2011 Cite

Quantitative neuromorphometry using magnetic resonance histology.

Journal Article Toxicol Pathol · January 2011 Featured Publication Magnetic resonance imaging (MRI), now common in the clinical domain, has been adapted for use by the neuropathologist by increasing the spatial resolution over 100,000 times what is common in human clinical imaging. This increase in spatial resolution has ... Full text Link to item Cite

Evaluation of tumor microenvironment in an animal model using a nanoparticle contrast agent in computed tomography imaging.

Journal Article Acad Radiol · January 2011 RATIONALE AND OBJECTIVES: Non-invasive longitudinal imaging of tumor vasculature could provide new insights into the development of solid tumors, facilitating efficient delivery of therapeutics. In this study, we report three-dimensional imaging and charac ... Full text Link to item Cite

Phenylephrine-modulated cardiopulmonary blood flow measured with use of X-ray digital subtraction angiography.

Journal Article J Pharmacol Toxicol Methods · 2011 INTRODUCTION: Cardiopulmonary blood flow is an important indicator of organ function. Limitations in measuring blood flow in live rodents suggest that rapid physiological changes may be overlooked. For instance, relative measurements limit imaging to whole ... Full text Link to item Cite

In vivo imaging of rat coronary arteries using bi-plane digital subtraction angiography.

Journal Article J Pharmacol Toxicol Methods · 2011 INTRODUCTION: X-ray based digital subtraction angiography (DSA) is a common clinical imaging method for vascular morphology and function. Coronary artery characterization is one of its most important applications. We show that bi-plane DSA of rat coronary ... Full text Link to item Cite

Micro-CT imaging assessment of dobutamine-induced cardiac stress in rats.

Journal Article J Pharmacol Toxicol Methods · 2011 INTRODUCTION: Dobutamine (DOB) stress in animal models of heart disease has been imaged so far using echocardiography and magnetic resonance imaging. The purpose of this study was to assess normal response to DOB stress in rats using anatomical and functio ... Full text Link to item Cite

Continuing education course #3: current practices and future trends in neuropathology assessment for developmental neurotoxicity testing.

Journal Article Toxicol Pathol · January 2011 The continuing education course on Developmental Neurotoxicity Testing (DNT) was designed to communicate current practices for DNT neuropathology, describe promising innovations in quantitative analysis and noninvasive imaging, and facilitate a discussion ... Full text Link to item Cite

Continuing education course #1: non-invasive imaging as a problem-solving tool and translational biomarker strategy in toxicologic pathology.

Journal Article Toxicol Pathol · January 2011 The continuing education course "Non-Invasive Imaging as a Problem-Solving Tool and Translational Biomarker Strategy in Toxicologic Pathology" provided a thorough overview of commonly used imaging modalities and the logistics required for integration of sm ... Full text Link to item Cite

Magnetic resonance microscopy-based analyses of the brains of normal and ethanol-exposed fetal mice.

Journal Article Birth Defects Res A Clin Mol Teratol · November 2010 BACKGROUND: The application of magnetic resonance microscopy (MRM) to the study of normal and abnormal prenatal mouse development has facilitated discovery of dysmorphology following prenatal ethanol insult. The current analyses extend this work, providing ... Full text Link to item Cite

Waxholm space: an image-based reference for coordinating mouse brain research.

Journal Article Neuroimage · November 1, 2010 Featured Publication We describe an atlas of the C57BL/6 mouse brain based on MRI and conventional Nissl histology. Magnetic resonance microscopy was performed on a total of 14 specimens that were actively stained to enhance tissue contrast. Images were acquired with three dif ... Full text Link to item Cite

Contrast-enhanced in vivo magnetic resonance microscopy of the mouse brain enabled by noninvasive opening of the blood-brain barrier with ultrasound.

Journal Article Magn Reson Med · October 2010 The use of contrast agents for neuroimaging is limited by the blood-brain barrier (BBB), which restricts entry into the brain. To administer imaging agents to the brain of rats, intracarotid infusions of hypertonic mannitol have been used to open the BBB. ... Full text Link to item Cite

Improving temporal resolution of pulmonary perfusion imaging in rats using the partially separable functions model.

Journal Article Magn Reson Med · October 2010 Dynamic contrast-enhanced MRI (or DCE-MRI) is a useful tool for measuring blood flow and perfusion, and it has found use in the study of pulmonary perfusion in animal models. However, DCE-MRI experiments are difficult in small animals such as rats. A recen ... Full text Link to item Cite

Static and dynamic cardiac modelling: Initial strides and results towards a quantitatively accurate mechanical heart model

Conference 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings · August 9, 2010 Magnetic Resonance Imaging (MRI) has exhibited significant potential for quantifying cardiac function and dysfunction in the mouse. Recent advances in highresolution cardiac MR imaging techniques have contributed to the development of acquisition approache ... Full text Cite

Multishot PROPELLER for high-field preclinical MRI.

Journal Article Magn Reson Med · July 2010 Featured Publication With the development of numerous mouse models of cancer, there is a tremendous need for an appropriate imaging technique to study the disease evolution. High-field T(2)-weighted imaging using PROPELLER (Periodically Rotated Overlapping ParallEL Lines with ... Full text Link to item Cite

Ultrasonic disruption of the blood-brain barrier enables in vivo functional mapping of the mouse barrel field cortex with manganese-enhanced MRI.

Journal Article Neuroimage · May 1, 2010 Though mice are the dominant model system for studying the genetic and molecular underpinnings of neuroscience, functional neuroimaging in mice remains technically challenging. One approach, Activation-Induced Manganese-enhanced MRI (AIM MRI), has been use ... Full text Link to item Cite

Microscopic diffusion tensor imaging of the mouse brain.

Journal Article Neuroimage · April 1, 2010 Featured Publication Diffusion tensor imaging (DTI) data at 43 mum isotropic resolution has been acquired on the intact adult mouse brain in 28-h scan time by using a streamlined protocol, including specimen fixation and staining, image acquisition, reconstruction, post-proces ... Full text Link to item Cite

Cardiovascular phenotyping of the mouse heart using a 4D radial acquisition and liposomal Gd-DTPA-BMA.

Journal Article Magn Reson Med · April 2010 MR microscopy has enormous potential for small-animal cardiac imaging because it is capable of producing volumetric images at multiple time points to accurately measure cardiac function. MR has not been used as frequently as ultrasound to measure cardiac f ... Full text Link to item Cite

Remote sites of structural atrophy predict later amyloid formation in a mouse model of Alzheimer's disease.

Journal Article Neuroimage · April 1, 2010 Featured Publication Magnetic resonance (MR) imaging can provide a longitudinal view of neurological disease through repeated imaging of patients at successive stages of impairment. Until recently, the difficulty of manual delineation has limited volumetric analyses of MR data ... Full text Link to item Cite

Quantitative analysis of hyperpolarized 3He ventilation changes in mice challenged with methacholine.

Journal Article Magn Reson Med · March 2010 The capability to use high-resolution (3)He MRI to depict regional ventilation changes and airway narrowing in mice challenged with methacholine (MCh) offers the opportunity to gain new insights into the study of asthma. However, to fully exploit the value ... Full text Link to item Cite

Ventilation/perfusion imaging in a rat model of airway obstruction.

Journal Article Magn Reson Med · March 2010 Featured Publication The global increase in asthma, chronic obstructive pulmonary disease, and other pulmonary diseases has stimulated interest in preclinical rat models of pulmonary disease. Imaging methods for study of these models is particularly appealing since the results ... Full text Link to item Cite

GPU-based iterative reconstruction with total variation minimization for micro-CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · 2010 Dynamic imaging with micro-CT often produces poorly-distributed sets of projections, and reconstructions of this data with filtered backprojection algorithms (FBP) may be affected by artifacts. Iterative reconstruction algorithms and total variation (TV) d ... Full text Cite

MAGNETIC RESONANCE IMAGING-BASED ANALYSES OF A FETAL ALCOHOL SPECTRUM DISORDERS MOUSE MODEL

Conference ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH · 2010 Cite

Active staining of mouse embryos for magnetic resonance microscopy.

Journal Article Methods Mol Biol · 2010 Featured Publication Magnetic resonance histology (MRH) has found considerable application in structural phenotyping in the mouse embryo. MRH employs the same fundamental principles as clinical MRI, albeit with spatial resolution up to six orders of magnitude higher than that ... Full text Link to item Cite

Free-space fluorescence tomography with adaptive sampling based on anatomical information from microCT.

Conference Proc SPIE Int Soc Opt Eng · 2010 Image reconstruction is one of the main challenges for fluorescence tomography. For in vivo experiments on small animals, in particular, the inhomogeneous optical properties and irregular surface of the animal make free-space image reconstruction challengi ... Full text Link to item Cite

Lung perfusion imaging in small animals using 4D micro-CT at heartbeat temporal resolution.

Journal Article Med Phys · January 2010 PURPOSE: Quantitative in vivo imaging of lung perfusion in rodents can provide critical information for preclinical studies. However, the combined challenges of high temporal and spatial resolution have made routine quantitative perfusion imaging difficult ... Full text Link to item Cite

Magnetic resonance microscopy defines ethanol-induced brain abnormalities in prenatal mice: effects of acute insult on gestational day 7.

Journal Article Alcohol Clin Exp Res · January 2010 BACKGROUND: This magnetic resonance microscopy (MRM)-based report is the second in a series designed to illustrate the spectrum of craniofacial and central nervous system (CNS) dysmorphia resulting from single- and multiple-day maternal ethanol treatment. ... Full text Link to item Cite

Purkinje cell loss in experimental autoimmune encephalomyelitis.

Journal Article Neuroimage · December 2009 Gray matter atrophy observed by brain MRI is an important correlate to clinical disability and disease duration in multiple sclerosis. The objective of this study was to link brain atrophy visualized by neuroimaging to its underlying neuropathology using t ... Full text Link to item Cite

High-resolution magnetic resonance angiography in the mouse using a nanoparticle blood-pool contrast agent.

Journal Article Magn Reson Med · December 2009 High-resolution magnetic resonance angiography is already a useful tool for studying mouse models of human disease. Magnetic resonance angiography in the mouse is typically performed using time-of-flight contrast. In this work, a new long-circulating blood ... Full text Link to item Cite

Quantitative blood flow measurements in the small animal cardiopulmonary system using digital subtraction angiography.

Journal Article Med Phys · November 2009 PURPOSE: The use of preclinical rodent models of disease continues to grow because these models help elucidate pathogenic mechanisms and provide robust test beds for drug development. Among the major anatomic and physiologic indicators of disease progressi ... Full text Link to item Cite

Dissecting the Mechanism of Tumor Response to Radiation Therapy with Primary Lung Cancers in Mice

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Rapid production of specialized animal handling devices using computer-aided design and solid freeform fabrication.

Journal Article J Magn Reson Imaging · August 2009 PURPOSE: To develop a process for rapidly and inexpensively producing customized animal handling devices for small animal imaging. MATERIALS AND METHODS: To meet the specific needs of a particular imaging experiment, measurements are taken from imaging dat ... Full text Link to item Cite

Genetic dissection of the mouse CNS using magnetic resonance microscopy.

Journal Article Curr Opin Neurol · August 2009 Featured Publication PURPOSE OF REVIEW: Advances in magnetic resonance microscopy (MRM) make it practical to map gene variants responsible for structural variation in brains of many species, including mice and humans. We review results of a systematic genetic analysis of MRM d ... Full text Link to item Cite

A material decomposition method for dual energy micro-CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · June 15, 2009 The attenuation of x-rays in matter is dependent on the energy of the x-rays and the atomic composition of the matter. Attenuation measurements at multiple x-ray energies can be used to improve the identification of materials. We present a method to estima ... Full text Cite

4D micro-CT-based perfusion imaging in small animals

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · June 15, 2009 Quantitative in-vivo imaging of lung perfusion in rodents can provide critical information for preclinical studies. However, the combined challenges of high temporal and spatial resolution have made routine quantitative perfusion imaging difficult in roden ... Full text Cite

Magnetic resonance microscopy defines ethanol-induced brain abnormalities in prenatal mice: effects of acute insult on gestational day 8.

Journal Article Alcohol Clin Exp Res · June 2009 BACKGROUND: Magnetic resonance microscopy (MRM), magnetic resonance imaging (MRI) at microscopic levels, provides unprecedented opportunities to aid in defining the full spectrum of ethanol's insult to the developing brain. This is the first in a series of ... Full text Link to item Cite

Genetic dissection of the mouse brain using high-field magnetic resonance microscopy.

Journal Article Neuroimage · May 1, 2009 Magnetic resonance (MR) imaging has demonstrated that variation in brain structure is associated with differences in behavior and disease state. However, it has rarely been practical to prospectively test causal models that link anatomical and functional d ... Full text Link to item Cite

Least-square NUFFT methods applied to 2-D and 3-D radially encoded MR image reconstruction.

Journal Article IEEE Trans Biomed Eng · April 2009 Radially encoded MRI has gained increasing attention due to its motion insensitivity and reduced artifacts. However, because its samples are collected nonuniformly in the k-space, multidimensional (especially 3-D) radially sampled MRI image reconstruction ... Full text Link to item Cite

Development of a noncontact 3-D fluorescence tomography system for small animal in vivo imaging.

Conference Proc SPIE Int Soc Opt Eng · February 16, 2009 Fluorescence imaging is an important tool for tracking molecular-targeting probes in preclinical studies. It offers high sensitivity, but nonetheless low spatial resolution compared to other leading imaging methods such CT and MRI. We demonstrate our metho ... Full text Link to item Cite

Three-dimensional reconstruction in free-space whole-body fluorescence tomography of mice using optically reconstructed surface and atlas anatomy.

Journal Article J Biomed Opt · 2009 We present a 3-D image reconstruction method for free-space fluorescence tomography of mice using hybrid anatomical prior information. Specifically, we use an optically reconstructed surface of the experimental animal and a digital mouse atlas to approxima ... Full text Link to item Cite

In vivo small-animal imaging using micro-CT and digital subtraction angiography.

Journal Article Phys Med Biol · October 7, 2008 Small-animal imaging has a critical role in phenotyping, drug discovery and in providing a basic understanding of mechanisms of disease. Translating imaging methods from humans to small animals is not an easy task. The purpose of this work is to review in ... Full text Link to item Cite

High-resolution magnetic resonance histology of the embryonic and neonatal mouse: a 4D atlas and morphologic database.

Journal Article Proc Natl Acad Sci U S A · August 26, 2008 Engineered mice play an ever-increasing role in defining connections between genotype and phenotypic expression. The potential of magnetic resonance microscopy (MRM) for morphologic phenotyping in the mouse has previously been demonstrated; however, applic ... Full text Link to item Cite

Application of MOSFET detectors for dosimetry in small animal radiography using short exposure times.

Journal Article Radiat Res · August 2008 Digital subtraction angiography (DSA) X-ray imaging for small animals can be used for functional phenotyping given its ability to capture rapid physiological changes at high spatial and temporal resolution. The higher temporal and spatial requirements for ... Full text Link to item Cite

A micro-CT analysis of murine lung recruitment in bleomycin-induced lung injury.

Journal Article J Appl Physiol (1985) · August 2008 The effects of lung injury on pulmonary recruitment are incompletely understood. X-ray computed tomography (CT) has been a valuable tool in assessing changes in recruitment during lung injury. With the development of preclinical CT scanners designed for th ... Full text Link to item Cite

Four-dimensional MR microscopy of the mouse heart using radial acquisition and liposomal gadolinium contrast agent.

Journal Article Magn Reson Med · July 2008 Magnetic resonance microscopy (MRM) has become an important tool for small animal cardiac imaging. In relation to competing technologies (microCT and ultrasound), MR is limited by spatial resolution, temporal resolution, and acquisition time. All three of ... Full text Link to item Cite

Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart.

Journal Article Development · May 2008 Septation of the mammalian heart into four chambers requires the orchestration of multiple tissue progenitors. Abnormalities in this process can result in potentially fatal atrioventricular septation defects (AVSD). The contribution of extracardiac cells t ... Full text Link to item Cite

Geometric calibration for a dual tube/detector micro-CT system.

Journal Article Med Phys · May 2008 The authors describe a dual tube/detector micro-computed tomography (micro-CT) system that has the potential to improve temporal resolution and material contrast in small animal imaging studies. To realize this potential, it is necessary to precisely calib ... Full text Link to item Cite

A dual micro-CT system for small animal imaging.

Conference Proc SPIE Int Soc Opt Eng · April 18, 2008 Micro-CT is a non-invasive imaging modality usually used to assess morphology in small animals. In our previous work, we have demonstrated that functional micro-CT imaging is also possible. This paper describes a dual micro-CT system with two fixed x-ray/d ... Full text Link to item Cite

Design of a superconducting volume coil for magnetic resonance microscopy of the mouse brain.

Journal Article J Magn Reson · April 2008 We present the design process of a superconducting volume coil for magnetic resonance microscopy of the mouse brain at 9.4T. The yttrium barium copper oxide coil has been designed through an iterative process of three-dimensional finite-element simulations ... Full text Link to item Cite

Left ventricle volume measurements in cardiac micro-CT: the impact of radiation dose and contrast agent.

Journal Article Comput Med Imaging Graph · April 2008 Micro-CT-based cardiac function estimation in small animals requires measurement of left ventricle (LV) volume at multiple time points during the cardiac cycle. Measurement accuracy depends on the image resolution, its signal and noise properties, and the ... Full text Link to item Cite

Multispectral imaging with three-dimensional rosette trajectories.

Journal Article Magn Reson Med · March 2008 Two-dimensional intersecting k-space trajectories have previously been demonstrated to allow fast multispectral imaging. Repeated sampling of k-space points leads to destructive interference of the signal coming from the off-resonance spectral peaks; on-re ... Full text Link to item Cite

A high-precision contrast injector for small animal x-ray digital subtraction angiography.

Journal Article IEEE Trans Biomed Eng · March 2008 The availability of genetically altered animal models of human disease for basic research has generated great interest in new imaging methodologies. Digital subtraction angiography (DSA) offers an appealing approach to functional imaging in small animals b ... Full text Link to item Cite

Pulmonary perfusion imaging in the rodent lung using dynamic contrast-enhanced MRI.

Journal Article Magn Reson Med · February 2008 With the development of various models of pulmonary disease, there is tremendous interest in quantitative regional assessment of pulmonary function. While ventilation imaging has been addressed to a certain extent, perfusion imaging for small animals has n ... Full text Link to item Cite

Predicting grade of cerebral glioma using vascular-space occupancy MR imaging.

Journal Article AJNR Am J Neuroradiol · February 2008 BACKGROUND AND PURPOSE: MR imaging can measure tissue perfusion and the integrity of the blood-brain barrier. We hypothesize that a combined measure of cerebral blood volume and vascular permeability using vascular-space occupancy (VASO) MR imaging, a rece ... Full text Link to item Cite

Optical clearing of unsectioned specimens for three-dimensional imaging via optical transmission and emission tomography.

Journal Article J Biomed Opt · 2008 Optical computed tomography (optical-CT) and optical emission computed tomography (optical-ECT) are new techniques that enable unprecedented high-resolution 3-D multimodal imaging of tissue structure and function. Applications include imaging macroscopic g ... Full text Link to item Cite

Automated segmentation of the actively stained mouse brain using multi-spectral MR microscopy.

Journal Article Neuroimage · January 1, 2008 Featured Publication Magnetic resonance microscopy (MRM) has created new approaches for high-throughput morphological phenotyping of mouse models of diseases. Transgenic and knockout mice serve as a test bed for validating hypotheses that link genotype to the phenotype of dise ... Full text Link to item Cite

3He MRI in mouse models of asthma.

Journal Article Magn Reson Med · November 2007 In the study of asthma, a vital role is played by mouse models, because knockout or transgenic methods can be used to alter disease pathways and identify therapeutic targets that affect lung function. Assessment of lung function in rodents by available met ... Full text Link to item Cite

Sparseness prior based iterative image reconstruction for retrospectively gated cardiac micro-CT.

Journal Article Med Phys · November 2007 Recent advances in murine cardiac studies with three-dimensional (3D) cone beam micro-CT used a retrospective gating technique. However, this sampling technique results in a limited number of projections with an irregular angular distribution due to the te ... Full text Link to item Cite

Brain atlasing tool interoperation: NeuroTerrain-Smart Atlas synergistic visualization and analysis environment

Conference Proceedings of the 3rd International IEEE EMBS Conference on Neural Engineering · September 25, 2007 Many research efforts using anatomical image analysis have as their goal to identify biologically relevant objects present within the image data, to provide a means to quantitatively analyze these objects, to compare the distribution of those objects to ot ... Full text Cite

Morphometric analysis of the C57BL/6J mouse brain.

Journal Article Neuroimage · September 1, 2007 Magnetic resonance microscopy (MRM), when used in conjunction with active staining, can produce high-resolution, high-contrast images of the mouse brain. Using MRM, we imaged in situ the fixed, actively stained brains of C57BL/6J mice in order to character ... Full text Link to item Cite

High-throughput morphologic phenotyping of the mouse brain with magnetic resonance histology.

Journal Article Neuroimage · August 1, 2007 Featured Publication The Mouse Biomedical Informatics Research Network (MBIRN) has been established to integrate imaging studies of the mouse brain ranging from three-dimensional (3D) studies of the whole brain to focused regions at a sub-cellular scale. Magnetic resonance (MR ... Full text Link to item Cite

Staining methods for magnetic resonance microscopy of the rat fetus.

Journal Article J Magn Reson Imaging · June 2007 PURPOSE: To develop a magnetic resonance histology (MRH) staining and fixation method by immersion to enhance the signal-to-noise ratio (SNR) with a paramagnetic contrast agent permitting microscopic acquisition within a 3-hour scan time. MATERIALS AND MET ... Full text Link to item Cite

High-resolution imaging of murine myocardial infarction with delayed-enhancement cine micro-CT.

Journal Article Am J Physiol Heart Circ Physiol · June 2007 The objective of this study was to determine the feasibility of delayed-enhancement micro-computed tomography (microCT) imaging to quantify myocardial infarct size in experimental mouse models. A total of 20 mice were imaged 5 or 35 days after surgical lig ... Full text Link to item Cite

Tomographic digital subtraction angiography for lung perfusion estimation in rodents.

Journal Article Med Phys · May 2007 In vivo measurements of perfusion present a challenge to existing small animal imaging techniques such as magnetic resonance microscopy, micro computed tomography, micro positron emission tomography, and microSPECT, due to combined requirements for high sp ... Full text Link to item Cite

Superparamagnetic iron oxide labeling and transplantation of adipose-derived stem cells in middle cerebral artery occlusion-injured mice.

Journal Article AJR Am J Roentgenol · April 2007 OBJECTIVE: Adipose-derived stem cells are an alternative stem cell source for CNS therapies. The goals of the current study were to label adipose-derived stem cells with superparamagnetic iron oxide (SPIO) particles, to use MRI to guide the transplantation ... Full text Link to item Cite

Neuroanatomical phenotypes in the reeler mouse.

Journal Article Neuroimage · February 15, 2007 The reeler mouse (Reln) has been proposed as a neurodevelopmental model for certain neurological and psychiatric conditions and has been studied by qualitative histochemistry and electron microscopy. Using magnetic resonance microscopy (MRM), we have quant ... Full text Link to item Cite

A micro-computed tomography-based method for the measurement of pulmonary compliance in healthy and bleomycin-exposed mice.

Journal Article Exp Lung Res · 2007 Micro-computed tomography (microCT) is being increasingly used to examine small animal models of pulmonary injury. The authors have developed a microCT technique suitable for the determination of pulmonary compliance in injured mice. Lung volumes in normal ... Full text Link to item Cite

Cardiac micro-computed tomography for morphological and functional phenotyping of muscle LIM protein null mice.

Journal Article Mol Imaging · 2007 The purpose of this study was to investigate the use of micro-computed tomography (micro-CT) for morphological and functional phenotyping of muscle LIM protein (MLP) null mice and to compare micro-CT with M-mode echocardiography. MLP null mice and controls ... Link to item Cite

Measurement and modeling of 4D live mouse heart volumes from CT time series

Conference Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2007 In vivo quantitative studies of cardiac function in mouse models provide information about cardiac pathophysiology in more detail than can be obtained in humans. Quantitative measurements of left ventricular (LV) volume at multiple contractile phases are p ... Full text Cite

Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI.

Journal Article Proc Natl Acad Sci U S A · November 28, 2006 Effective pulmonary gas exchange relies on the free diffusion of gases across the thin tissue barrier separating airspace from the capillary red blood cells (RBCs). Pulmonary pathologies, such as inflammation, fibrosis, and edema, which cause an increased ... Full text Link to item Cite

Micro radiography imaging of the rodent with phenylephrine induced vascular hypertension

Conference 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings · November 17, 2006 Vascular tonicity plays a major role in regulating the blood pressure and the perfusion of organs, and hypertension is a major cause of morbidity and mortality in humans. We use phenylephrine, a vasoconstrictor, to create a model of hypertension in the rat ... Cite

Multimodality imaging of pulmonary function in the rodent

Conference 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings · November 17, 2006 The high spatial and temporal resolution demands for imaging physiological function in the rodent call for the use of novel ways to combine information from different imaging modalities. This work describes ventilation imaging using hyperpolarized (HP) 3He ... Cite

Functional imaging in small animals using tomographic digital subtraction angiography

Conference 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings · November 17, 2006 We propose the use of Tomographic Digital Subtraction Angiography (TDSA) for functional imaging in small animals. TDSA combines the advantages of high temporal resolution of digital subtraction angiography (DSA) and high spatial resolution of micro-compute ... Cite

Optimized radiographic spectra for small animal digital subtraction angiography.

Journal Article Med Phys · November 2006 The increasing use of small animals in basic research has spurred interest in new imaging methodologies. Digital subtraction angiography (DSA) offers a particularly appealing approach to functional imaging in the small animal. This study examines the optim ... Full text Link to item Cite

Enhanced T2 contrast for MR histology of the mouse brain.

Journal Article Magn Reson Med · October 2006 A 3D Carr-Purcell-Meiboom-Gill (CPMG) sequence was implemented to obtain enhanced T(2) contrast in actively stained (perfusion with fixative and contrast agent) mouse brains at 9.4 T. Short interecho spacing was used to minimize diffusion and susceptibilit ... Full text Link to item Cite

Three-dimensional imaging of xenograft tumors using optical computed and emission tomography.

Journal Article Med Phys · September 2006 The physical basis and preliminary applications of optical computed tomography (optical-CT) and optical emission computed tomography (optical-ECT) are introduced, as new techniques with potential to provide unique 3D information on a variety of aspects of ... Full text Link to item Cite

A liposomal nanoscale contrast agent for preclinical CT in mice.

Journal Article AJR Am J Roentgenol · February 2006 OBJECTIVE: The goal of this study was to determine if an iodinated, liposomal contrast agent could be used for high-resolution, micro-CT of low-contrast, small-size vessels in a murine model. MATERIALS AND METHODS: A second-generation, liposomal blood pool ... Full text Link to item Cite

Magnetic resonance microscopy

Chapter · January 1, 2006 Visualization of internal structures of opaque biologic objects is essential in many biomedical studies. Limited by the penetration depth of the probing sources (photons and electrons) and the lack of endogenous contrast, conventional forms of microscopy s ... Cite

MO‐D‐330D‐01: Molecular Imaging I: The Physics of Molecular Imaging

Conference Medical Physics · January 1, 2006 The first day of the Molecular Imaging Symposium (MI‐1) will focus on the technology aspects of molecular, functional, and small animal imaging. Modalities which will be discussed include micro‐CT, micro‐PET, and high resolution MRI for small animal imagin ... Full text Cite

Optimization of multiplanar reformations from isotropic data sets acquired with 16-detector row helical CT scanner.

Journal Article Radiology · January 2006 Institutional review board approval and waiver of consent were obtained for the patient component of this retrospective HIPAA-compliant study. By using an anthropomorphic phantom and metal oxide semiconductor field effect transistor detectors, radiation do ... Full text Link to item Cite

Tumor imaging in small animals with a combined micro-CT/micro-DSA system using iodinated conventional and blood pool contrast agents.

Journal Article Contrast Media Mol Imaging · 2006 X-ray based micro-computed tomography (CT) and micro-digital subtraction angiography (DSA) are important non-invasive imaging modalities for following tumorogenesis in small animals. To exploit these imaging capabilities further, the two modalities were co ... Full text Link to item Cite

Imaging methods for morphological and functional phenotyping of the rodent heart.

Journal Article Toxicol Pathol · 2006 Small animal imaging has a critical role in phenotyping, drug discovery, and in providing a basic understanding of mechanisms of disease. Translating imaging methods from humans to small animals is not an easy task. The purpose of this work is to compare t ... Full text Link to item Cite

Automated segmentation of neuroanatomical structures in multispectral MR microscopy of the mouse brain.

Journal Article Neuroimage · August 15, 2005 Featured Publication We present the automated segmentation of magnetic resonance microscopy (MRM) images of the C57BL/6J mouse brain into 21 neuroanatomical structures, including the ventricular system, corpus callosum, hippocampus, caudate putamen, inferior colliculus, intern ... Full text Link to item Cite

Reproductive cytotoxicity is predicted by magnetic resonance microscopy and confirmed by ubiquitin-proteasome immunohistochemistry in a theophylline-induced model of rat testicular and epididymal toxicity.

Journal Article Microsc Microanal · August 2005 This study investigated the testicular changes in the rat induced by the nonspecific phosphodiesterase inhibitor, theophylline using magnetic resonance microscopy (MRM) and ubiquitin immunostaining techniques. In vivo T1- and T2-weighted images were acquir ... Full text Link to item Cite

Magnetic resonance imaging at microscopic resolution reveals subtle morphological changes in a mouse model of dopaminergic hyperfunction.

Journal Article Neuroimage · May 15, 2005 Structural abnormalities of the basal ganglia have been documented in several neuropsychiatric conditions associated with dysregulation of the dopamine system. However, the histological nature underlying these changes is largely unknown. Using magnetic res ... Full text Link to item Cite

Effects of breathing and cardiac motion on spatial resolution in the microscopic imaging of rodents.

Journal Article Magn Reson Med · April 2005 One can acquire high-resolution pulmonary and cardiac images in live rodents with MR microscopy by synchronizing the image acquisition to the breathing cycle across multiple breaths, and gating to the cardiac cycle. The precision with which one can synchro ... Full text Link to item Cite

Ventilation-synchronous magnetic resonance microscopy of pulmonary structure and ventilation in mice.

Journal Article Magn Reson Med · January 2005 Increasing use of transgenic animal models for pulmonary disease has raised the need for methods to assess pulmonary structure and function in a physiologically stable mouse. We report here an integrated protocol using magnetic resonance microscopy with ga ... Full text Link to item Cite

4-D micro-CT of the mouse heart.

Journal Article Mol Imaging · 2005 PURPOSE: Demonstrate noninvasive imaging methods for in vivo characterization of cardiac structure and function in mice using a micro-CT system that provides high photon fluence rate and integrated motion control. MATERIALS AND METHODS: Simultaneous cardia ... Full text Link to item Cite

Morphology of the small-animal lung using magnetic resonance microscopy.

Conference Proc Am Thorac Soc · 2005 Small-animal imaging with magnetic resonance microscopy (MRM) has become an important tool in biomedical research. When MRM is used to image perfusion-fixed and "stained" whole mouse specimens, cardiopulmonary morphology can be visualized, nondestructively ... Full text Link to item Cite

Micro-CT with respiratory and cardiac gating.

Journal Article Med Phys · December 2004 Cardiopulmonary imaging in rodents using micro-computed tomography (CT) is a challenging task due to both cardiac and pulmonary motion and the limited fluence rate available from micro-focus x-ray tubes of most commercial systems. Successful imaging in the ... Full text Link to item Cite

Utilizing MRI information to estimate F18-FDG distributions in rat flank tumors

Conference IEEE Nuclear Science Symposium Conference Record · December 1, 2004 This paper investigates the potential of magnetic resonance imaging (MRI) to improve the estimation of within-tumor variations in F18-FDG concentration. An image model is described for incorporating MRI images into positron emission tomography (PET) and si ... Cite

Optimized radiographic spectra for digital subtraction angiography in the mouse

Conference 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano · December 1, 2004 The availability of genetically altered mouse models of human disease and the increasing use of small animals in basic research have spurred extraordinary interest in new imaging methodologies - particularly magnetic resonance microscopy, microCT, and micr ... Cite

Volumetric micro-CT system for in vivo microscopy

Conference 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano · December 1, 2004 Two of the major barriers to improved image quality in micro-CT are the reduced signal to noise imposed by the smaller voxels and the effects of physiologic motion. The most direct approach to increase the signal to noise ratio (SNR) is to increase the flu ... Cite

Effects of breathing motion on the spatial resolution in microscopic imaging techniques of rodents

Conference 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano · December 1, 2004 Magnetic resonance microscopy is capable of producing high-resolution pulmonary images in live rodents by synchronizing the image acquisition across multiple breaths. The precision with which one can control motion will probably define the resolution limit ... Cite

Dynamic lung morphology of methacholine-induced heterogeneous bronchoconstriction.

Journal Article Magn Reson Med · November 2004 Hyperpolarized (HP) 3helium (3He) dynamic MRI was used to investigate airway response in rats following intravenous (i.v.) bolus administration of a contractile agent, methacholine (MCh). The method provides direct visualization of the ventilated regions w ... Full text Link to item Cite

Neurotoxicity of carbonyl sulfide in F344 rats following inhalation exposure for up to 12 weeks.

Journal Article Toxicol Appl Pharmacol · October 15, 2004 Carbonyl sulfide (COS), a high-priority Clean Air Act chemical, was evaluated for neurotoxicity in short-term studies. F344 rats were exposed to 75-600 ppm COS 6 h per day, 5 days per week for up to 12 weeks. In rats exposed to 500 or 600 ppm for up to 4 d ... Full text Link to item Cite

Cine magnetic resonance microscopy of the rat heart using cardiorespiratory-synchronous projection reconstruction.

Journal Article J Magn Reson Imaging · July 2004 PURPOSE: To tailor a cardiac magnetic resonance (MR) microscopy technique for the rat that combines improvements in pulse sequence design and physiologic control to acquire high-resolution images of cardiac structure and function. MATERIALS AND METHODS: Pr ... Full text Link to item Cite

Measurement of fat/water ratios in rat liver using 3D three-point dixon MRI.

Journal Article Magn Reson Med · April 2004 Hepatic steatosis, or fatty liver, is commonly observed during the animal phase of drug safety studies. A noninvasive three-dimensional (3D) three-point Dixon method was used to quantitatively evaluate the fatty livers of rats induced by an experimental mi ... Full text Link to item Cite

Functional pulmonary MR microscopy in mice

Journal Article FASEB JOURNAL · March 24, 2004 Link to item Cite

Contribution of magnetic resonance microscopy in the 12-week neurotoxicity evaluation of carbonyl sulfide in Fischer 344 rats.

Journal Article Toxicol Pathol · 2004 In this carbonyl sulfide (COS) study, magnetic resonance microscopy (MRM) and detailed light microscopic evaluation effectively functioned in parallel to assure that the distribution and degree of pathology in the brain was accurately represented. MRM is a ... Full text Link to item Cite

Applications of magnetic resonance microscopy.

Journal Article Toxicol Pathol · 2004 Magnetic resonance imaging (MRI) has enjoyed enormous clinical success since the first demonstration of the method more than 30 years ago. An increasing number of pharmaceutical manufacturers seeking new biomarkers for assessing drug efficacy and toxicity ... Full text Link to item Cite

Development of a 4-D digital mouse phantom for molecular imaging research.

Journal Article Mol Imaging Biol · 2004 PURPOSE: We develop a realistic and flexible 4-D digital mouse phantom and investigate its usefulness in molecular imaging research. METHODS: Organ shapes were modeled with non-uniform rational B-spline (NURBS) surfaces based on high-resolution 3-D magneti ... Full text Link to item Cite

Myocardial volume and organization are changed by failure of addition of secondary heart field myocardium to the cardiac outflow tract.

Journal Article Dev Dyn · October 2003 Cardiac neural crest ablation results in primary myocardial dysfunction and failure of the secondary heart field to add the definitive myocardium to the cardiac outflow tract. The current study was undertaken to understand the changes in myocardial charact ... Full text Link to item Cite

Improved preparation of chick embryonic samples for magnetic resonance microscopy.

Journal Article Magn Reson Med · June 2003 Previous work demonstrated the power of three-dimensional (3D) magnetic resonance microscopy (MRM) to follow complicated morphologic development in the embryonic cardiovascular system. In this study we describe a new dual-contrast method for specimen prepa ... Full text Link to item Cite

Optimization of eight-element multi-detector row helical CT technology for evaluation of the abdomen.

Journal Article Radiology · June 2003 PURPOSE: To evaluate protocols for abdominal imaging with an eight-element multi-detector row computed tomographic (CT) scanner. MATERIALS AND METHODS: An eight-element helical CT scanner was used to acquire data in two phantoms with four-element (pitch, 0 ... Full text Link to item Cite

Magnetic resonance microscopy

Chapter · January 1, 2003 Visualization of internal structures of opaque biologic objects is essential in many biomedical studies. Limited by the penetration depth of the probing sources (photons and electrons) and the lack of endogenous contrast, conventional forms of microscopy s ... Cite

Measurement of regional lung function in rats using hyperpolarized 3helium dynamic MRI.

Journal Article Magn Reson Med · January 2003 Dynamic regional lung function was investigated in rats using a radial acquisition cine (RA-CINE) pulse sequence together with hyperpolarized (HP) (3)He gas delivered by a constant flow ventilator. Based on regional differences in the behavior of inspired ... Full text Link to item Cite

Magnetic resonance histology for morphologic phenotyping.

Journal Article J Magn Reson Imaging · October 2002 Magnetic resonance histology (MRH) images of the whole mouse have been acquired at 100-micron isotropic resolution at 2.0 T with image arrays of 256 x 256 x 1024. Higher resolution (50 x 50 x 50 microns) of limited volumes has been acquired at 7.1T with im ... Full text Link to item Cite

Application of magnetic resonance microscopy to tissue engineering: a polylactide model.

Journal Article J Biomed Mater Res · September 5, 2002 Absorbable polymers are unique materials that find application as temporary scaffolds in tissue engineering. They are often extremely sensitive to histological processing and, for this reason, studying fragile, tissue-engineered constructs before implantat ... Full text Link to item Cite

Imaging inflammation: direct visualization of perivascular cuffing in EAE by magnetic resonance microscopy.

Journal Article J Magn Reson Imaging · July 2002 PURPOSE: To determine if the architectural features revealed by magnetic resonance microscopy (MRM) allow one to detect microscopic abnormalities associated with neuroinflammation in fixed brain sections from animals with experimental allergic encephalomye ... Full text Link to item Cite

MRI of the lungs using hyperpolarized noble gases.

Journal Article Magn Reson Med · June 2002 The nuclear spin polarization of the noble gas isotopes (3)He and (129)Xe can be increased using optical pumping methods by four to five orders of magnitude. This extraordinary gain in polarization translates directly into a gain in signal strength for MRI ... Full text Link to item Cite

Morphologic phenotyping with MR microscopy: the visible mouse.

Journal Article Radiology · March 2002 Featured Publication A method for rapid morphologic phenotyping is demonstrated by using magnetic resonance microscopy. Whole fixed C57BL/6J mice were imaged at 110-microm isotropic resolution; limited volumes of the intact specimen, at 50-microm isotropic resolution; and isol ... Full text Link to item Cite

Fiber-optic stethoscope: a cardiac monitoring and gating system for magnetic resonance microscopy.

Journal Article Magn Reson Med · February 2002 A fundamental problem associated with using the conventional electrocardiograph (ECG) to monitor a subject's cardiac activity during magnetic resonance imaging (MRI) is the distortion of the ECG due to electromagnetic interference. This problem is particul ... Full text Link to item Cite

Image based phenotyping: The visible mouse

Journal Article FASEB JOURNAL · 2002 Featured Publication Cite

Mechanical ventilation for imaging the small animal lung.

Journal Article ILAR J · 2002 This review emphasizes some of the challenges and benefits of in vivo imaging of the small animal lung. Because mechanical ventilation plays a key role in high-quality, high-resolution imaging of the small animal lung, the article focuses particularly on t ... Full text Link to item Cite

Liver: single breath-hold dynamic subtraction CT with multi-detector row helical technology feasibility study.

Journal Article Radiology · January 2002 Fifty-two patients with known or suspected hypervascular malignancy were examined to determine the technical feasibility of performing single-breath-hold dynamic subtraction computed tomography (CT) of the liver with multi-detector row helical CT. The prec ... Full text Link to item Cite

An engineering approach to image-based phenotyping

Conference 2002 IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING, PROCEEDINGS · 2002 Featured Publication Cite

Using technology to develop a hepatic lipidosis blomarker in the rat

Journal Article MOLECULAR BIOLOGY OF THE CELL · November 1, 2001 Link to item Cite

Diabetes insipidus in uricase-deficient mice: a model for evaluating therapy with poly(ethylene glycol)-modified uricase.

Journal Article J Am Soc Nephrol · May 2001 Uricase-deficient mice develop uric acid nephropathy, with high mortality rates before weaning. Urate excretion was quantitated and renal function was better defined in this study, to facilitate the use of these mice as a model for evaluating poly(ethylene ... Full text Link to item Cite

Registered (1)H and (3)He magnetic resonance microscopy of the lung.

Journal Article Magn Reson Med · March 2001 Using in vivo magnetic resonance microscopy, registered (1)H and hyperpolarized (3)He images of the rat lung were obtained with a resolution of 0.098 x 0.098 x 0.469 mm (4.5 x 10(-3) mm(3)). The requisite stability and SNR was achieved through an integrati ... Full text Link to item Cite

Measurements of hyperpolarized gas properties in the lung. Part III: (3)He T(1).

Journal Article Magn Reson Med · March 2001 Hyperpolarized (3)He spin-lattice relaxation was investigated in the guinea pig lung using spectroscopy and imaging techniques with a repetitive RF pulse series. T(1) was dominated by interactions with oxygen and was used to measure the alveolar O(2) parti ... Full text Link to item Cite

Distributed multiuser visualization of time varying anatomical data

Conference Proceedings - Applied Imagery Pattern Recognition Workshop · January 1, 2001 We describe a networked environment for navigating and visualizing 3-dimensional anatomical data with extensions for time varying volumes. The Duke Center for In Vivo Microscopy (CIVM) has been capturing volumetric data of mice using magnetic resonance mic ... Full text Cite

Detection of emphysema in rat lungs by using magnetic resonance measurements of 3He diffusion.

Journal Article Proc Natl Acad Sci U S A · October 10, 2000 Emphysema is a pulmonary disease characterized by alveolar wall destruction, resulting in enlargement of gas exchange spaces without fibrosis. This condition is a part of chronic obstructive pulmonary disease (COPD), which causes 3.5% of deaths worldwide [ ... Full text Link to item Cite

MR-compatible ventilator for small animals: computer-controlled ventilation for proton and noble gas imaging.

Journal Article Magn Reson Imaging · July 2000 We describe an MR-compatible ventilator that is computer controlled to generate a variety of breathing patterns, to minimize image degrading effects of breathing motion, and to support delivery of gas anesthesia and experimental inhalational gases. A key f ... Full text Link to item Cite

Magnetic resonance microscopy of the C57BL mouse brain.

Journal Article Neuroimage · June 2000 With the rapid progression in gene technologies, transgenic, targeted, and chemically induced mutations in mice are continually created. The major goal of these studies is to understand and characterize the effects of genotype on anatomy, physiology, and b ... Full text Link to item Cite

Mixing oxygen with hyperpolarized (3)He for small-animal lung studies.

Journal Article NMR Biomed · June 2000 Hyperpolarized helium (HP (3)He) is useful for direct MR imaging of the gas spaces of small animal lungs. Previously, breaths of 100% HP (3)He were alternated with breaths of air to maximize helium signal in the lungs and to minimize the depolarizing effec ... Full text Link to item Cite

T1rho imaging using magnetization-prepared projection encoding (MaPPE).

Journal Article Magn Reson Med · March 2000 T1rho contrast weighting using a magnetization-prepared projection encoding (MaPPE) pulse sequence was investigated. Fast radial imaging was implemented by applying magnetization preparation pulses, each followed by multiple RF alpha pulses encoding radial ... Full text Link to item Cite

Hyperpolarized 3He microspheres as a novel vascular signal source for MRI.

Journal Article Magn Reson Med · March 2000 Hyperpolarized (HP) 3He can be encapsulated within biologically compatible microspheres while retaining sufficient polarization to be used as a signal source for MRI. Two microsphere sizes were used, with mean diameters of 5.3 +/- 1.3 microm and 10.9 +/- 3 ... Full text Link to item Cite

Abnormal water metabolism in mice lacking the type 1A receptor for ANG II.

Journal Article Am J Physiol Renal Physiol · January 2000 Mice lacking AT(1A) receptors for ANG II have a defect in urinary concentration manifested by an inability to increase urinary osmolality to levels seen in controls after thirsting. This defect results in extreme serum hypertonicity during water deprivatio ... Full text Link to item Cite

Virtual neuropathology: three-dimensional visualization of lesions due to toxic insult.

Journal Article Toxicol Pathol · 2000 A first-pass approach incorporating high-field magnetic resonance imaging (MRI) was used for rapid detection of neuropathologic lesions in fixed rat brains. This inherently 3-dimensional and nondestructive technique provides high-resolution, high-contrast ... Full text Link to item Cite

Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy.

Journal Article Proc Natl Acad Sci U S A · November 23, 1999 Magnetic resonance microscopy (MRM) theoretically provides the spatial resolution and signal-to-noise ratio needed to resolve neuritic plaques, the neuropathological hallmark of Alzheimer's disease (AD). Two previously unexplored MR contrast parameters, T2 ... Full text Link to item Cite

Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part II: T *(2).

Journal Article Magn Reson Med · October 1999 The transverse relaxation time, T *(2), of hyperpolarized (HP) gas in the lung in vivo is an important parameter for pulse sequence optimization and image contrast. We obtained T *(2) maps of HP (3)He and (129)Xe in guinea pig lungs (n = 17) and in human l ... Full text Link to item Cite

Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: diffusion coefficient.

Journal Article Magn Reson Med · October 1999 In imaging of hyperpolarized noble gases, a knowledge of the diffusion coefficient (D) is important both as a contrast mechanism and in the design of pulse sequences. We have made diffusion coefficient maps of both hyperpolarized (3)He and (129)Xe in guine ... Full text Link to item Cite

A high-temperature superconducting Helmholtz probe for microscopy at 9.4 T.

Journal Article Magn Reson Med · May 1999 The design and operation of a high-temperature superconducting (HTS) probe for magnetic resonance microscopy (MRM) at 400 MHz are presented. The design of the probe includes a Helmholtz coil configuration and a stable open-cycle cooling mechanism. Characte ... Full text Link to item Cite

Magnetic resonance angiography with hyperpolarized 129Xe dissolved in a lipid emulsion.

Journal Article Magn Reson Med · May 1999 Hyperpolarized (HP) 129Xe can be dissolved in biologically compatible lipid emulsions while maintaining sufficient polarization for in vivo vascular imaging. For xenon in Intralipid 30%, in vitro spectroscopy at 2 T yielded a chemical shift of 197 +/- 1 pp ... Full text Link to item Cite

Functional MR microscopy of the lung using hyperpolarized 3He.

Journal Article Magn Reson Med · April 1999 A new strategy designed to provide functional magnetic resonance images of the lung in small animals at microscopic resolution using hyperpolarized 3He is described. The pulse sequence is based on a combination of radial acquisition (RA) and CINE technique ... Full text Link to item Cite

Sensitivity and resolution in 3D NMR microscopy of the lung with hyperpolarized noble gases.

Journal Article Magn Reson Med · April 1999 Three-dimensional magnetic resonance images of the guinea pig lung were acquired in vivo using hyperpolarized (HP) noble gases and radial projection encoding (PE). Results obtained with 3He (voxel size 17 microl) demonstrated high image quality showing air ... Full text Link to item Cite

3-Dimensional visualization of lesions in rat brain using magnetic resonance imaging microscopy.

Journal Article Neuroreport · March 17, 1999 High-resolution (< 50 microm) magnetic resonance imaging microscopy (MRM) has been used to identify brain regions and localization of excitotoxin-induced lesions in fixed rat brains, subsequently confirmed using standard histology. The anatomical extent of ... Full text Link to item Cite

Magnetic resonance imaging of embryos: an Internet resource for the study of embryonic development.

Journal Article Comput Med Imaging Graph · 1999 The recent amassing of gene expression data to study development in mammals has led to an increased demand for access to human embryological data. The difficulty of obtaining well-preserved human embryos presents an important challenge to studying human de ... Full text Link to item Cite

In vivo diffusion-weighted magnetic resonance microscopy of rat spinal cord: effect of ischemia and intrathecal hyperbaric 5% lidocaine.

Journal Article Reg Anesth Pain Med · 1999 BACKGROUND AND OBJECTIVES: Pathophysiologic mechanisms underlying persistent neurologic deficits after continuous spinal anesthesia using hyperbaric 5% lidocaine are still not well understood. It has been suggested that high-dose intrathecal lidocaine indu ... Full text Link to item Cite

Performance of a high-temperature superconducting probe for in vivo microscopy at 2.0 T.

Journal Article Magn Reson Med · January 1999 The use of a high-temperature superconducting probe for in vivo magnetic resonance microscopy at 2 T is described. To evaluate the performance of the probe, a series of SNR comparisons are carried out. The SNR increased by a factor of 3.7 compared with an ... Full text Link to item Cite

Signal dynamics in magnetic resonance imaging of the lung with hyperpolarized noble gases.

Journal Article J Magn Reson · November 1998 The nonequilibrium bulk magnetic moment of hyperpolarized (HP) noble gases generated by optical pumping has unique characteristics. Based on the Bloch equations, a model was developed describing the signal dynamics of HP gases used in magnetic resonance im ... Full text Link to item Cite

In vivo magnetic resonance vascular imaging using laser-polarized 3He microbubbles.

Journal Article Proc Natl Acad Sci U S A · September 1, 1998 Laser-polarized gases (3He and 129Xe) are currently being used in magnetic resonance imaging as strong signal sources that can be safely introduced into the lung. Recently, researchers have been investigating other tissues using 129Xe. These studies use xe ... Full text Link to item Cite

Measuring the progression of foreign-body reaction to silicone implants using in vivo MR microscopy.

Journal Article IEEE Trans Biomed Eng · July 1998 We used in vivo magnetic resonance (MR) microscopy to follow the growth of fibrous capsule as a foreign body reaction to silicone implants in rats. Anesthetized rats were imaged 1, 7, 14, and 28 days after silicone-coated MR imaging coils were sutured to t ... Full text Link to item Cite

Hyperpolarized 3He NMR lineshape measurements in the live guinea pig lung.

Journal Article Magn Reson Med · July 1998 Spatially localized lineshapes of hyperpolarized (HP) 3He in guinea pig lungs have been measured in vivo. Three different axial slice locations, each containing different compositions of airway sizes and orientations, were studied. Gas peaks from major bro ... Full text Link to item Cite

Time-course imaging of rat embryos in utero with magnetic resonance microscopy.

Journal Article Magn Reson Med · April 1998 Magnetic resonance (MR) microscopy was used to noninvasively investigate the development of live rat embryos in utero. The difficulty in making sequential observations of a developing mammalian embryo has frustrated developmental biologists for many years. ... Full text Link to item Cite

Magnetic resonance microscopy and histopathology: comparative approach of bromobenzene-induced hepatotoxicity in the rat.

Journal Article Hepatology · February 1998 The development of magnetic resonance (MR) microscopy has provided new approaches to histology and histopathology. Recent work has shown the promise of increased sensitivity in animal models of chemically induced hepatotoxicity. However, the field is so ne ... Full text Link to item Cite

A new window into the lung

Journal Article Physics World · January 1, 1998 Full text Cite

A fast spin echo technique with circular sampling.

Journal Article Magn Reson Med · January 1998 This paper presents a fast spin echo (FSE) imaging method that employs circular sampling of k-space. The technique has been implemented on a 2 Tesla imaging system and validated on both phantoms and living animals. Experimental studies have shown that circ ... Full text Link to item Cite

Spinal cord neural anatomy in rats examined by in vivo magnetic resonance microscopy.

Journal Article Reg Anesth Pain Med · 1998 BACKGROUND AND OBJECTIVES: Magnetic resonance microscopy (MRM) is a technique that is worthwhile for anesthesiologists because it allows spinal cord and plexus anatomy to be visualized three dimensionally and followed over time in the same animal. For exam ... Full text Link to item Cite

MR microscopy of lung airways with hyperpolarized 3He.

Journal Article Magn Reson Med · January 1998 A technique using hyperpolarized (HP) 3He to image the small airways of the lung by using moderate flip angles and a short scanning period during early inspiration is demonstrated. Flip angles (alpha) ranging from 10-90 degrees were used in guinea pig expe ... Full text Link to item Cite

Magnetic resonance imaging of hyperpolarized 129Xe produced by spin exchange with diode-laser pumped Cs

Journal Article Applied Physics Letters · 1998 We report the results of experiments leading to the production of an image of a polarized 129Xe sample prepared by spin exchange with Cs, optically pumped with a spectrally narrowed 894.3 nm diode laser. Representative images of th ... Full text Cite

MR microimaging of the lung using volume projection encoding.

Journal Article Magn Reson Med · December 1997 Radial acquisition (RA) techniques have been extended to produce isotropic, three-dimensional images of lung in live laboratory animals at spatial resolution down to 0.013 mm3 with a signal-to-noise ratio of 30:1. The pulse sequence and reconstruction algo ... Full text Link to item Cite

Magnetic resonance imaging of continuous spinal anesthesia with hyperbaric lidocaine: Root or white matter lesion?

Journal Article Regional Anesthesia · December 1, 1997 Introduction: Persistent neurologic deficits in patients after continuous spinal anesthesia with hyperbaric lidocaine may have been erroneously characterized as a cauda equina syndrome (1,2). First, clinical reports of symptoms rarely include pain (typical ... Cite

Automated feedback control of body temperature for small animal studies with MR microscopy.

Journal Article IEEE Trans Biomed Eng · November 1997 A temperature control system consisting of a thermistor, signal processor, and computer algorithm was developed for magnetic resonance (MR) microscopy of small live animals. With control of body temperature within +/- 0.2 degree C of the set point, heart r ... Full text Link to item Cite

Dynamics of magnetization in hyperpolarized gas MRI of the lung.

Journal Article Magn Reson Med · July 1997 The magnetization in hyperpolarized gas (HP) MRI is generated by laser polarization that is independent of the magnet and imaging process. As a consequence, there is no equilibrium magnetization during the image acquisition. The competing processes of gas ... Full text Link to item Cite

Magnetic resonance microscopy in basic studies of brain structure and function.

Journal Article Ann N Y Acad Sci · May 30, 1997 Featured Publication Full text Link to item Cite

Convection and flow in porous media. Part 1. Visualization by magnetic resonance imaging

Journal Article Journal of Fluid Mechanics · February 10, 1997 We describe an experimental study of porous media convection (PMC) from onset to 8Rac. The goal of this work is to provide non-invasive imaging and high-precision heat transport measurements to test theories of convection in PMC. We obtain velocity informa ... Full text Cite

Root form and function meshed by MRI.

Journal Article PLANT PHYSIOLOGY · 1997 Cite

Optimized radiofrequency coils for increased signal-to-noise ratio in magnetic resonance microscopy

Journal Article International Journal of Imaging Systems and Technology · January 1, 1997 The signal-to-noise ratio (SNR) is a major obstacle to achieving increased resolution in magnetic resonance microscopy (MRM). The SNR considerations for MRM are presented, with particular attention to the role of judicious receiver coil design in maximizin ... Full text Cite

Progression of a focal ischemic lesion in rat brain during treatment with a novel glycine/NMDA antagonist: an in vivo three-dimensional diffusion-weighted MR microscopy study.

Journal Article J Magn Reson Imaging · 1997 Stroke was induced in two groups of anesthetized rats by occlusion of the middle cerebral artery (MCA) and ipsilateral common carotid artery. Group 1 (control) received vehicle and group 2 received the glycine N-methyl-D-aspartate (NMDA) antagonist ZD9379. ... Full text Link to item Cite

Quality control phantom for digital chest radiography.

Journal Article Radiology · January 1997 PURPOSE: To develop and test a chest phantom for routine quality control testing of digital radiography systems. MATERIALS AND METHODS: The phantom was constructed from sheets of copper, aluminum, and acrylic, which were cut and arranged to yield a radiogr ... Full text Link to item Cite

Tumor cell endocytosis imaging facilitates delineation of the glioma-brain interface.

Journal Article Exp Neurol · January 1997 We describe a method for measuring tumor cell endocytosis in vivo and provide the anatomic correlate of this tumor cell function using a superparamagnetic and histologically detectable marker for cell uptake (MION). Rats (n = 22) were intrahemispherically ... Full text Link to item Cite

Quality control phantom for digital chest radiography

Journal Article RADIOLOGY · November 1, 1996 Link to item Cite

Functional imaging of the lung.

Journal Article Nat Med · November 1996 Full text Link to item Cite

Human lung air spaces: potential for MR imaging with hyperpolarized He-3.

Journal Article Radiology · August 1996 Two healthy volunteers who had inhaled approximately 0.75 L of laser-polarized helium-3 gas underwent magnetic resonance imaging at 1.5 T with fast gradient-echo pulse sequences and small flip angles ( < 10 degrees). Thick-section (20 mm) coronal images, t ... Full text Link to item Cite

A new in vivo method for quantitative analysis of stroke lesions using diffusion-weighted magnetic resonance microscopy.

Journal Article Neuroimage · June 1996 Using three-dimensional diffusion-weighted MR microscopy and a rat model of focal cerebral ischemia, we evaluated the statistical characteristics of two parameters: absolute stroke volumes and change in stroke volumes over 6 h of middle cerebral artery (MC ... Full text Link to item Cite

In vivo He-3 MR images of guinea pig lungs.

Journal Article Radiology · June 1996 The authors imaged the lungs of live guinea pigs with hyperpolarized (HP) helium-3 as a magnetic resonance (MR) signal source. HP He-3 gas produced through spin exchange with rubidium metal vapor was delivered through an MR-compatible, small-animal ventila ... Full text Link to item Cite

T1 rho relaxation and its application to MR histology.

Journal Article Magn Reson Med · May 1996 The application of T1 rho an an alternative contrast parameter in high-field magnetic resonance histology (MRH) has been investigated. Spectroscopic measurements of T1 rho were performed on 5.75% agar and 1.0 mM MnCI2 phantoms at 9.4 T to validate the accu ... Full text Link to item Cite

Magnetic resonance microscopy of embryos.

Journal Article Comput Med Imaging Graph · 1996 We demonstrate that magnetic resonance (MR) microscopy provides a mechanism to investigate normal and abnormal developmental anatomy in a non-destructive and distortion-free manner. Techniques for the fixation, embedding, perfusion and image acquisition of ... Full text Link to item Cite

Magnetic resonance microscopy--a new tool for the toxicologic pathologist.

Journal Article Toxicol Pathol · 1996 Parallel to its many applications in medical imaging, magnetic resonance (MR) microscopy is a potentially powerful tool in toxicologic pathology. Because of the intrinsic qualities of MR microscopy (noninvasiveness, 3-dimensionality, and slicing in any cho ... Full text Link to item Cite

Multiple-window spectrum estimation applied to in vivo NMR spectroscopy

Journal Article Journal of Magnetic Resonance - Series B · 1996 Multiple-window spectrum estimation (MWSE) is a method of deriving frequency spectra from time series. A set of apodizing windows is applied to the time data and each windowed data set is Fourier transformed. The windows are prolate spheroidal sequences. T ... Cite

Detection of bromobenzene-induced hepatocellular necrosis using magnetic resonance microscopy.

Journal Article Magn Reson Med · December 1995 The authors used magnetic resonance (MR) microscopy to assess hepatic tissue damage induced by bromobenzene both in living rats and in fixed rat liver tissues. Experiments were conducted at 7 Tesla on three groups of Fisher rats treated with bromobenzene a ... Full text Link to item Cite

A methodology for co-registering abdominal MR images over multiple breath-holds.

Journal Article Magn Reson Med · November 1995 Previous studies have demonstrated that the SNR of abdominal MR images can be increased by averaging images obtained in different breath-hold acquisitions. In this note, the authors present a simple new methodology for ensuring that images acquired in mult ... Full text Link to item Cite

MR microscopy of the rat carotid artery after balloon injury by using an implanted imaging coil.

Journal Article Magn Reson Med · June 1995 Neointimal hyperplasia after angioplasty was followed in vivo in rats by using MR microscopy and surgically implanted RF imaging coils. By using an inductively coupled pick-up coil, the arteries were imaged 4 days before and 3, 7, and 14 days after angiopl ... Full text Link to item Cite

MR imaging with hyperpolarized 3He gas.

Journal Article Magn Reson Med · February 1995 Magnetic resonance images of the lungs of a guinea pig have been produced using hyperpolarized helium as the source of the MR signal. The resulting images are not yet sufficiently optimized to reveal fine structural detail within the lung, but the spectacu ... Full text Link to item Cite

Performance of a High-Temperature Superconducting Resonator for High-Field Imaging

Journal Article Journal of Magnetic Resonance, Series A · January 1, 1995 The practicalities involved with the use of a superconducting microimaging probe are outlined so that the power and problems associated with this technology can be assessed. The nonlinearity of the transmission characteristics of this class of probe, the i ... Full text Cite

Magnetic resonance microscopy of the rat carotid artery at 300 megahertz.

Journal Article Invest Radiol · September 1994 RATIONALE AND OBJECTIVES: Magnetic resonance microscopy (MRM) has evolved from a technical curiosity to a tool with which researchers can study important disease models. But MRM is not simply an extension of clinical magnetic resonance imaging. In this art ... Full text Link to item Cite

Three dimensional magnetic resonance microangiography of rat neurovasculature.

Journal Article Magn Reson Med · August 1994 Techniques are described to perform three dimensional (3D) MR microangiography. We have combined the use of a blood pool agent (Gd-DTPA-complexed with bovine serum albumin), three dimensional Fourier encoding, careful animal stabilization, and volume rende ... Full text Link to item Cite

Studies on bromobenzene-induced hepatotoxicity using in vivo MR microscopy with surgically implanted RF coils.

Journal Article Magn Reson Med · June 1994 Using surgically implanted RF coils at 300 MHz, three-dimensional microscopic MR images of rat liver were obtained in vivo to follow the development of pathology induced by bromobenzene exposure. Formalin fixed specimens of liver from these animals were al ... Full text Link to item Cite

Imaging the cochlea by magnetic resonance microscopy.

Journal Article Hear Res · May 1994 The isolated, fixed cochlea of the mustached bat was studied with three dimensional magnetic resonance (MR) microscopy. The cochlea of this animal is about 4 mm in diameter and its entire volume was imaged. With the field of view and matrix size used, the ... Full text Link to item Cite

Magnetic resonance imaging of chronic myocardial infarcts in formalin-fixed human autopsy hearts.

Journal Article Circulation · May 1994 BACKGROUND: In post-myocardial infarction patients, three-dimensional structure of the infarct as well as infarct size are likely to be important factors affecting mortality, cardiac function, and arrhythmias. Current morphological methods for determining ... Full text Link to item Cite

Magnetic resonance microscopy of mouse embryos.

Journal Article Proc Natl Acad Sci U S A · April 26, 1994 The increased use of the mouse as a model for various aspects of mammalian biology has caused a renewed interest in developing strategies for examining and comparing normal and abnormal mouse embryonic development and anatomy. In this study, we have explor ... Full text Link to item Cite

Utility of postmortem magnetic resonance imaging in clinical neuropathology.

Journal Article Arch Pathol Lab Med · March 1994 Over 200 brains were examined by postmortem magnetic resonance imaging to determine the utility of this imaging procedure as an adjunct to the standard postmortem examination of the brain and spinal cord. One unembalmed cadaver was also studied using a con ... Link to item Cite

MAGNETIC-RESONANCE MICROSCOPY OF WATER-MOVEMENT THROUGH FUSIFORM RUST GALLS OF PINE

Conference RESEARCH AND APPLICATIONS OF CHEMICAL SCIENCES IN FORESTRY · 1994 Cite

MAGNETIC-RESONANCE MICROSCOPY (MRM) OF WATER TRANSPORT AND BINDING IN FUSIFORM RUST GALLS

Conference RESEARCH AND APPLICATIONS OF CHEMICAL SCIENCES IN FORESTRY · January 1, 1994 Link to item Cite

NONDESTRUCTIVE, 3-DIMENSIONAL STUDY OF ROOT-GROWTH WITH MAGNETIC-RESONANCE MICROSCOPY (MRM)

Conference RESEARCH AND APPLICATIONS OF CHEMICAL SCIENCES IN FORESTRY · January 1, 1994 Link to item Cite

Detection of infarcted tissue the heart by magnetic resonance imaging

Journal Article Proceedings of the Annual Conference on Engineering in Medicine and Biology · December 1, 1993 Morphological analysis of myocardial infarct structure has demonstrated that there is probably an anatomical basis for the induction and maintenance of ventricular tachycardia. The further study of this phenomenon requires an efficient, accurate method for ... Cite

Diffusion-weighted MR microscopy with fast spin-echo.

Journal Article Magn Reson Med · August 1993 A diffusion-weighted fast spin-echo (FSE) imaging sequence for high-field MR microscopy was developed and experimentally validated in a phantom and in a live rat. Pulsed diffusion gradients were executed before and after the initial 180 degrees pulse in th ... Full text Link to item Cite

High-field MR microscopy using fast spin-echoes.

Journal Article Magn Reson Med · July 1993 Fast spin-echo imaging has been investigated with attention to the requirements and opportunities for high-field MR microscopy. Two- and three-dimensional versions were implemented at 2.0 T, 7.1 T, and 9.4 T. At these fields, at least eight echoes were col ... Full text Link to item Cite

Histology by magnetic resonance microscopy.

Journal Article Magn Reson Q · March 1993 Featured Publication Magnetic resonance microscopy (MRM) has advanced from a technical challenge to a practical tool in a wide range of basic sciences. This article focuses on the use of MRM as a tool for histological studies. The technical challenges of limited signal to nois ... Link to item Cite

A high-temperature superconducting receiver for nuclear magnetic resonance microscopy.

Journal Article Science · February 5, 1993 A high-temperature superconducting-receiver system for use in nuclear magnetic resonance (NMR) microscopy is described. The scaling behavior of sources of sample and receiver-coil noise is analyzed, and it is demonstrated that Johnson, or thermal, noise in ... Full text Link to item Cite

Magnetic resonance imaging of leaves

Journal Article New Phytologist · January 1, 1993 Several aspects of leaf anatomy and morphology make it difficult to image leaves with magnetic resonance imaging. Since most fully expanded leaves contain much intercellular air space and are often thin in one plane, relatively few water protons are availa ... Full text Cite

In vitro MR microscopy of the hippocampus in Alzheimer's disease.

Journal Article Neurology · January 1993 We used MR microscopy at 7 tesla to identify the anatomy of the degenerating hippocampus in Alzheimer's disease (AD), which we then correlated with the histopathologic findings in the same specimens. The specimens studied were resected postmortem from 13 p ... Full text Link to item Cite

Reduction of ringing and blurring artifacts in fast spin-echo imaging.

Journal Article J Magn Reson Imaging · 1993 A simple method was devised to reduce ringing and blurring artifacts caused by discontinuous T2 weighting of k-space data in fast spin-echo magnetic resonance (MR) imaging. The method demodulates the weighting function along the phase-encoding direction by ... Full text Link to item Cite

MR microscopy of the rat lung using projection reconstruction.

Journal Article Magn Reson Med · January 1993 Projection reconstruction has been implemented with self-refocused selection pulses on a small bore, 2.0 T MR microscope, to allow imaging of lung parenchyma. Scan synchronous ventilation and cardiac gating have been integrated with the sequence to minimiz ... Full text Link to item Cite

Observation of the Oxygen Diffusion Barrier in Soybean (Glycine max) Nodules with Magnetic Resonance Microscopy.

Journal Article Plant Physiol · December 1992 The effects of selected gas perfusion treatments on the spinlattice relaxation times (T(1)) of the soybean (Glycine max) nodule cortex and inner nodule tissue were studied with (1)H high resolution magnetic resonance microscopy. Three gas treatments were u ... Full text Link to item Cite

In vivo magnetic resonance imaging of the blue crab, Callinectes sapidus: effect of cadmium accumulation in tissues on proton relaxation properties.

Journal Article J Exp Zool · August 1, 1992 Nuclear magnetic resonance imaging (MRI) has been used to visualize the internal anatomy of a living blue crab. The resolution obtained in these studies was sufficient to distinguish individual organs by the differences in their proton densities and proton ... Full text Link to item Cite

Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy.

Journal Article Stroke · May 1992 BACKGROUND AND PURPOSE: The aim of this study was to measure apparent diffusion coefficients in rat brain tissue exposed to ouabain, glutamate, and N-methyl-D-aspartate and to compare them with apparent diffusion coefficients found in acute cerebral ischem ... Full text Link to item Cite

A probe for specimen magnetic resonance microscopy.

Journal Article Invest Radiol · February 1992 One of the primary limits to spatial resolution in magnetic resonance (MR) microscopy is the limited signal. The purpose of this study is to build a radiofrequency (rf) probe for MR microscopy of fixed specimens at 300 MHz. The design criteria for the prob ... Full text Link to item Cite

Surface coil imaging of rat spine at 7.0 T.

Journal Article Magn Reson Imaging · 1992 An inductively coupled surface coil for imaging the rat spine at 7 T is described. This planar circular probe was made from microwave substrate to limit the size of the coil and to minimize the magnetic susceptibility. The surface coil was used as a single ... Full text Link to item Cite

MR microscopy of chick embryo vasculature.

Journal Article J Magn Reson Imaging · 1992 Six-day-old chick embryos were examined with magnetic resonance microscopy after vascular perfusion fixation and perfusion with gadolinium-doped gelatin to high-light the developing vascular anatomy. Gadolinium gelatin, with its short T1, provided a source ... Full text Link to item Cite

Distinguishing Plant Tissues with Magnetic Resonance Microscopy

Journal Article American Journal of Botany · December 1991 Full text Cite

Magnetic resonance imaging of interstitial velocity distributions in porous media

Journal Article American Society of Mechanical Engineers, Fluids Engineering Division (Publication) FED · December 1, 1991 In this article we report on a promising application of Magnetic Resonance Imaging (MRI), which can measure local interstitial velocity distributions inside fully-saturated porous media. We have extended the standard three-dimensional MRI sequence to inclu ... Cite

Small object contrast in AMBER and conventional chest radiography.

Journal Article Radiology · September 1991 The ability of a commercially available scanning equalization system for chest radiography to render small object contrast in the lung-, mediastinum-, and subdiaphragm-equivalent regions of an acrylic chest phantom was quantitatively evaluated. Images from ... Full text Link to item Cite

Pre- and postmortem diffusion coefficients in rat neural and muscle tissues.

Journal Article Magn Reson Med · July 1991 Pulsed gradient diffusion-weighted spin-echo images (7 to 11 gradient strengths) were obtained in a coronal slice through the midbrain for five normal adult white rats before and after sacrifice in a 2-T CSI system with air temperature control. The pulse s ... Full text Link to item Cite

Diffusion/microcirculation MRI in the rat brain.

Journal Article Magn Reson Med · June 1991 The CO2 fraction of an anesthetized rat's breathing mixture was changed (from 0 to 10%) to attempt to change the brain microcirculation and observe these changes in diffusion measurements of the neural tissue. Brain apparent diffusion coefficients were mea ... Full text Link to item Cite

In vivo measurement of proton diffusion in the presence of coherent motion.

Journal Article Invest Radiol · June 1991 Measurement of the self-diffusion coefficient D of water in tissue has been performed traditionally using the technique proposed by Stejskal and Tanner. A variant of that technique is shown here, employing flow-compensated gradients that significantly redu ... Full text Link to item Cite

Magnetic resonance microscopy of toxic renal injury induced by bromoethylamine in rats.

Journal Article Fundam Appl Toxicol · May 1991 The alkylhalide 2-bromoethylamine hydrobromide (BEA) produces renal injury in rats that mimics analgesic-related renal injury in humans. Our purpose was to examine this injury, in vivo in rats, with magnetic resonance (MR) microscopy and correlate MR findi ... Full text Link to item Cite

Three-dimensional MR microscopy with large arrays.

Journal Article Magn Reson Med · March 1991 MR microscopy of fixed specimens is described using large (256(3] arrays. Images are acquired at 7.0 T with voxels as small as 70 x 70 x 70 microns (3.4 x 10(-4) mm3), more than 25,000 times smaller than routine clinical body imaging. Separation of the acq ... Full text Link to item Cite

Quantitative proton magnetic resonance imaging in focal cerebral ischemia in rat brain.

Journal Article Stroke · February 1991 Proton magnetic resonance (MR) imaging has been recommended as a diagnostic tool for the detection of focal cerebral ischemia. We compared microscopic MR images of rat brains after focal cerebral ischemia with evidence of histological damage found on corre ... Full text Link to item Cite

Magnetic resonance imaging of interstitial velocity distributions in porous media

Journal Article · January 1, 1991 In this article we report on a promising application of Magnetic Resonance Imaging (MRI), which can measure local interstitial velocity distributions inside fully-saturated porous media. We have extended the standard three-dimensional MRI sequence to inclu ... Cite

Comparative water uptake by roots of different ages in seedlings of loblolly pine (Pinus taeda L.)

Journal Article New Phytologist · January 1, 1991 Magnetic resonance (MR) imaging was used to study water absorption from fine, moist sand by the taproot, first‐order lateral roots, and tine roots of 9‐month‐old loblolly pine seedlings. Magnetic resonance imaging provides the opportunity for repeated non‐ ... Full text Cite

TIME-DEPENDENCE, SCALING AND PATTERN-FORMATION FOR FLOWING SAND

Journal Article EUROPEAN JOURNAL OF MECHANICS B-FLUIDS · January 1, 1991 Link to item Cite

MR imaging of microcirculation in rat brain: correlation with carbon dioxide-induced changes in blood flow.

Journal Article J Magn Reson Imaging · 1991 Considerable interest has been shown in developing a magnetic resonance (MR) imaging technique with quantitative capability in the evaluation of tissue microcirculation ("perfusion"). In the present study, the flow-dephased/flow-compensated (FD/FC) techniq ... Full text Link to item Cite

MR microscopy at 7.0 T: effects of brain iron.

Journal Article J Magn Reson Imaging · 1991 The T2 of brain tissue is known to be field dependent, decreasing as B0 increases. Previous studies have attributed reduced T2 in the structures of the extrapyramidal motor system (EPMS) to high iron concentrations. The present study was designed to manipu ... Full text Link to item Cite

Maximization of contrast-to-noise ratio to distinguish diffusion and microcirculatory flow.

Journal Article J Magn Reson Imaging · 1991 Optimization of the contrast-to-noise ratio (CNR) is described for microcirculation magnetic resonance (MR) imaging techniques based on flow-compensated/flow-dephased sequences, both with and without even-echo rephasing. The authors present the most advant ... Full text Link to item Cite

The use of gradient flow compensation to separate diffusion and microcirculatory flow in MRI.

Journal Article Magn Reson Med · January 1991 This paper describes a new MR imaging technique termed Modified Stejskal Tanner versus Flow Compensation (MST/FC) for the separation of diffusion and microcirculatory flow. The theory behind the sequence is explained, along with a five-component model of m ... Full text Link to item Cite

Magnetic resonance imaging of interstitial velocity distributions in porous media

Journal Article · January 1, 1991 In this article we report on a promising application of Magnetic Resonance Imaging (MRI), which can measure local interstitial velocity distributions inside fully-saturated porous media. We have extended the standard three-dimensional MRI sequence to inclu ... Cite

Magnetic resonance microscopy of toxic renal injury induced by Bromoethylamine in rats

Journal Article Toxicological Sciences · January 1, 1991 Magnetic Resonance Microscopy of Toxic Renal Injury Induced by Bromoethylamine in Rats. Hedlund, L. W., Maronpot, R. R., Johnson, G. A., Cofer, G. P., Mills, G. I., and Wheeler, C. T. (1991). Fundam. Appl. Toxicol. 16, 787-797. The alkylhalide 2-bromoethyl ... Full text Cite

Computer tomographic analysis of water distribution and flow in porous media

Journal Article Theoretical and Applied Climatology · December 1, 1990 Computer tomography (CT) is the reconstruction by computer of a tomographic plane (slice) of an object. The tomograph is developed from multiple X-ray absorption measurements (scans) made around the periphery of the object. Recent research in soil science ... Full text Cite

Use of nuclear magnetic resonance microscopy for noninvasive observations of root-soil water relations

Journal Article Theoretical and Applied Climatology · December 1, 1990 As part of our strategy to study root-soil water relationships, it was necessary to develop a nondestructive technique to detect small changes in water distribution in and near the root. Nuclear magnetic resonance imaging (MRI), clinically used to nondestr ... Full text Cite

MR diffusion measurements in stroke models in rat brains

Journal Article Proceedings of the Annual Conference on Engineering in Medicine and Biology · December 1, 1990 It is shown that tissue self-diffusion coefficients can be calculated from a series of diffusion-weighted MR (magnetic resonance) images. By variation of the time between diffusion sensitizing gradient pulses, the motions of tissue water may be characteriz ... Cite

Maximizing contrast to noise with inductively coupled implanted coils.

Journal Article Invest Radiol · May 1990 Magnetic resonance (MR) microscopy with inductively coupled implanted coils has been used previously to follow loss and return of intra-medullary contrast as a result of nephrotoxic acute tubular necrosis with 117 microns resolution over a 2000 microns thi ... Full text Link to item Cite

Observation of a water-depletion region surrounding loblolly pine roots by magnetic resonance imaging.

Journal Article Proc Natl Acad Sci U S A · February 1, 1990 Magnetic resonance imaging was used to study sand containing various amounts of water and roots of loblolly pine planted into similar sand. Spin-lattice (T1) relaxation times of sand with water contents ranging from 0 to 25% (wt/wt) ranged from 472 to 1265 ... Full text Link to item Cite

Magnetic resonance imaging of the thoracic cavity using a paused 3DFT acquisition technique.

Journal Article Magn Reson Imaging · 1990 A new pulse sequence designed for magnetic resonance imaging of the entire thoracic cavity is described. This sequence, called 3DPAUSE, is a rapid three-dimensional Fourier transform (3DFT) sequences with periodic pauses for breathing and additional rf pul ... Full text Link to item Cite

Integrated network for medical imaging research

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · 1990 There are a number of generic problems that researchers in medical imaging have in common. For example, researchers in MR, CT, PET, SPECT, DSA, and digital radiography all need to display and window digital images. We describe here an integrated with tools ... Cite

Image optimization in a computed-radiography/photostimulable-phosphor system.

Journal Article J Digit Imaging · November 1989 Photostimulable phosphor imaging is an exciting new technology that has several advantages over film/screen radiography, the most important of which is the linearity of the photostimulable phosphor system over a wide exposure latitude. The photostimulable ... Full text Link to item Cite

Relaxation measurements at 300 MHz using MR microscopy.

Journal Article Magn Reson Med · August 1989 Previous data on changes in tissue T1 with field have suggested the convergence of tissue T1 values toward a common value at high (greater than 4.0 T) fields. Measures of T2 dependence have suggested reduction of T2 with field. The purpose of this study wa ... Full text Link to item Cite

Magnetic resonance imaging of hepatic neoplasms in the rat.

Journal Article Vet Pathol · July 1989 Magnetic resonance imaging (MRI) at microscopic resolution was done on a live rat that had chemically induced hepatic neoplasms. Beginning at the anterior aspect of the liver, 16 contiguous transaxial slices (each 1.25 mm thick) were produced using three-d ... Full text Link to item Cite

Pattern formation in flowing sand.

Journal Article Phys Rev Lett · June 12, 1989 Full text Link to item Cite

Implanted coil MR microscopy of renal pathology.

Journal Article Magn Reson Med · June 1989 Inductively coupled implanted coils have been shown to provide up to a 10-fold increase in signal-to-noise ratio when compared to whole-body imaging of small animals. The current study was designed to extend the implanted coil imaging technique to a rodent ... Full text Link to item Cite

Three-dimensional imaging of the thoracic cavity.

Journal Article Invest Radiol · April 1989 Three-dimensional (3D) surface reconstruction techniques were applied to sets of computed tomographic (CT) images of the thoracic cavity. Emphasis was placed on extracting lung images. High quality, detailed 3D images of the lung surface and internal bronc ... Full text Link to item Cite

In vivo magnetic resonance microscopy at 5 μm

Journal Article Journal of Magnetic Resonance (1969) · January 1, 1989 Full text Cite

Vascular morphology by three-dimensional magnetic resonance imaging.

Journal Article Magn Reson Imaging · 1989 A three-dimensional examination of blood vessels is provided using MR data from seven cases. The vascular surfaces are constructed with an algorithm that automatically follows the selected artery or vein and generates a projected three-dimensional gradient ... Full text Link to item Cite

Magnetic resonance microscopy of chemically-induced liver foci.

Journal Article Toxicol Pathol · 1989 Magnetic resonance imaging (MRI) is a new imaging technique used in clinical diagnosis. This paper describes extension of the technique to basic research applications--specifically detecting and characterizing chemically-induced liver neoplasms and foci of ... Full text Link to item Cite

Chemical shift imaging of atherosclerosis at 7.0 Tesla.

Journal Article Invest Radiol · January 1989 Chemical shift imaging (CSI) was performed on cadaveric atherosclerotic fibrous plaques, periaortic adipose tissue, and cholesterol standards using a 7.0 Tesla horizontal bore prototype imaging spectrometer. Proton spectroscopy of intact tissue and deutera ... Full text Link to item Cite

THE IMPACT OF INCREASED SPIN-LATTICE RELAXATION-TIME MICROSCOPY AT 7.0T

Journal Article INVESTIGATIVE RADIOLOGY · September 1, 1988 Link to item Cite

MR MICROSCOPY OF NEPHROTOXIC ACUTE TUBULAR-NECROSIS IN THE RAT

Journal Article INVESTIGATIVE RADIOLOGY · September 1, 1988 Link to item Cite

INVITRO CHEMICAL-SHIFT IMAGING OF ATHEROSCLEROSIS AT 7.0-TESLA

Journal Article INVESTIGATIVE RADIOLOGY · September 1, 1988 Link to item Cite

MR MICROSCOPY USING DRIVEN EQUILIBRIUM (DEFT)

Journal Article INVESTIGATIVE RADIOLOGY · September 1, 1988 Link to item Cite

DEVELOPMENT OF A 3D RECONSTRUCTED-IMAGE SURGICAL PLANNING STATION

Journal Article INVESTIGATIVE RADIOLOGY · September 1, 1988 Link to item Cite

Film-Based Digital Tomosynthesis Of The Chest

Journal Article Optical Engineering · August 1, 1988 Full text Cite

Magnetic resonance microscopy of chick embryos in ovo.

Journal Article Teratology · July 1988 Magnetic resonance imaging (MRI) of the live 11-day chick embryo with special radiofrequency coils and 3-D imaging methods has produced contiguous 1.25-mm-thick slices with 200-microns pixel resolution, permitting definition of cardiac chambers, cerebral v ... Full text Link to item Cite

MR imaging of the knee: preliminary results with a 3DFT GRASS pulse sequence.

Journal Article AJR Am J Roentgenol · March 1988 The knees of 17 patients (18 extremities) with possible meniscal, cruciate ligament, and articular cartilage abnormalities were examined with a three-dimensional Fourier transform (3DFT), gradient-refocused acquisition in a steady state (GRASS) pulse seque ... Full text Link to item Cite

Effects of image processing on nodule detection rates in digitized chest radiographs: ROC study of observer performance.

Journal Article Radiology · February 1988 To evaluate the effects of image processing in digitized chest radiographs when high-resolution images are used, an examination was done in which the detection of pulmonary nodules in unprocessed digitized chest radiographs was compared with that in images ... Full text Link to item Cite

Magnetic resonance microscopy: in vivo sectioning of a developing insect.

Journal Article Experientia · January 15, 1988 The utility of magnetic resonance imaging vis-a-vis insect morphology and development was investigated. MRI is a noninvasive technique that distinguishes between tissues based on proton content and proton 'environment'. At present a resolution of 100 micro ... Full text Link to item Cite

Magnetic resonance imaging (MRI): a new tool in experimental toxicologic pathology.

Journal Article Toxicol Pathol · 1988 Magnetic Resonance Imaging (MRI) is a noninvasive imaging technique that provides multidimensional images of the soft tissues of the body. This imaging technique has proven to be an excellent diagnostic and experimental tool for the detection of pathologic ... Full text Link to item Cite

SNR improvement in NMR microscopy using DEFT

Journal Article Journal of Magnetic Resonance (1969) · January 1, 1988 This paper examines the use of a driven equilibrium Fourier transform (DEFT) pulse sequence for improving the signal per unit time and hence image resolution in NMR microscopy. DEFT vs partial saturation (PS) is modeled and it is shown that DEFT is most us ... Full text Cite

In situ magnetic resonance microscopy.

Journal Article Invest Radiol · December 1987 Recent developments in MR permit imaging at microscopic resolution. Efforts have focused on small samples that fit entirely in the imaging probe. Extension of the techniques to imaging of individual organs in small animals is complicated by both the need t ... Full text Link to item Cite

MAGNETIC-RESONANCE-IMAGING OF ROOT-WATER DISTRIBUTION

Journal Article HORTSCIENCE · October 1, 1987 Link to item Cite

Magnetic resonance imaging in multiple sclerosis: decreased signal in thalamus and putamen.

Journal Article Ann Neurol · October 1987 High-field strength (1.5 Tesla) magnetic resonance imaging in 15 patients with multiple and extensive white-matter lesions and clinically definite multiple sclerosis delineated a previously undescribed finding of abnormally decreased signal intensity on T2 ... Full text Link to item Cite

177. SMALL ANIMAL ANESTHESIA AND MONITORING DURING EXTENDED MR MICROSCOPY

Journal Article Investigative Radiology · September 1987 Full text Cite

RESOLUTION LIMITS IN MR - MR MICROSCOPY

Journal Article MEDICAL PHYSICS · May 1, 1987 Link to item Cite

Magnetic resonance microscopy of changes in water content in stems of transpiring plants.

Journal Article Proc Natl Acad Sci U S A · May 1987 Differences in water content and degree of binding in the various stem tissues of Pelargonium hortorum were observed by magnetic resonance imaging. 1H images were obtained with a resolution of 100 microns in the transverse plane and a slice thickness of 12 ... Full text Link to item Cite

Three-dimensional MRI microscopy of the normal rat brain.

Journal Article Magn Reson Med · April 1987 Featured Publication Magnetic resonance imaging techniques have been developed to enable imaging of the live rat brain with thin (1.2-mm) slices and microscopic pixels (115 X 115 microns). Signal-to-noise ratios high enough to realize the microscopic resolution are obtained wi ... Full text Link to item Cite

Two-second MR images: comparison with spin-echo images in 29 patients.

Journal Article AJR Am J Roentgenol · March 1987 MR images can be obtained with a 2-sec scan time when an extremely short repetition rate (22 msec), limited flip angle (30 degrees), and gradient refocused echoes are used. Comparison of 415 such images obtained in 29 patients with routine T1-weighted (TR ... Full text Link to item Cite

Differentiation of benign from malignant pulmonary nodules with digitized chest radiographs.

Journal Article Radiology · March 1987 To assess whether it is possible to distinguish benign from malignant solitary pulmonary nodules with digital techniques, a retrospective study of 68 patients with proved solitary nodules was performed. The conventional chest radiograph for each patient wa ... Full text Link to item Cite

Contrast enhancement of the liver. Evaluation by automated contiguous pixel search.

Journal Article Invest Radiol · February 1987 Eight dogs were infused with one of three different contrast agents: meglumine diatrizoate, iosulamide meglumine, or an ethiodized oil emulsion (EOE 13). Image intensity in the liver was evaluated globally and regionally by means of an automated pixel samp ... Full text Link to item Cite

IMPLEMENTATION OF ADAPTIVE FILTRATION FOR DIGITAL CHEST IMAGING.

Journal Article Optical Engineering · January 1, 1987 Full text Cite

COMPUTED TOMOGRAPHIC ANALYSES OF WATER DISTRIBUTION IN THREE POROUS FOAM MEDIA.

Journal Article Soil Science Society of America Journal · January 1, 1987 Computer Assisted Tomography (CAT) is commonly used in diagnostic radiology to make nondestructive images and analyses of cross sections of the human body. CAT scanning may also be useful in imaging and measuring spatial distribution and changes in water d ... Full text Cite

Signal-to-noise improvements in three-dimensional NMR microscopy using limited-angle excitation

Journal Article Journal of Magnetic Resonance (1969) · January 1, 1987 The 3D FT variant of spin-echo imaging has previously been successfully used to yield images at microscopic resolution. In obtaining such high resolution, optimization of signal to noise for a given acquisition time is crucial. Using a limited-angle (<60) ... Full text Cite

Rapid calculation of T1 using variable flip angle gradient refocused imaging.

Journal Article Magn Reson Imaging · 1987 We present a method for rapid measurement of T1 relaxation times using gradient refocused images at limited flip angles and short repetition times. This "variable nutation" techniques was investigated using a T1 phantom. There was a high correlation betwee ... Full text Link to item Cite

Methodology for the measurement and analysis of relaxation times in proton imaging.

Journal Article Magn Reson Imaging · 1987 Measurements of proton T1 and T2 were performed on GdCl3 solutions (20 less than T2 less than 500 msec, 90 less than T1 less than 1000 msec) on large-bore NMR imaging systems operating at 1.0T and 1.5T. CPMG multi-echo (ME), multiple saturation recovery (M ... Full text Link to item Cite

Regionally adaptive histogram equalization of the chest.

Journal Article IEEE Trans Med Imaging · 1987 Advances in the area of digital chest radiography have resulted in the acquisition of high-quality images of the human chest. With these advances, there arises a genuine need for image processing algorithms specific to the chest, in order to fully exploit ... Full text Link to item Cite

Performance of high-resolution monitors for digital chest imaging.

Journal Article Med Phys · 1987 High-resolution cathode-ray tubes (CRT's) are currently the most viable soft-copy display for digital radiography. We present here methods for measuring large-area contrast ratio and detail contrast ratio. A two-dimensional charge coupled device (ccd) arra ... Full text Link to item Cite

REGIONALLY ADAPTIVE HISTOGRAM EQUALIZATION OF THE CHEST.

Journal Article IEEE Transactions on Medical Imaging · 1987 The authors have implemented the well-known technique of histogram equalization, noting the problems encountered when it is adapted to chest images. These problems have been successfully solved with a regionally adaptive histogram equalization method. With ... Cite

In Vivo Magnetic Resonance Microscopy of Changing Water Content in Pelargonium hortorum Roots.

Journal Article Plant Physiol · December 1986 Magnetic resonance imaging (MRI) was used to nondestructively observe changes in water content in roots of Pelargonium hortorum x Bailey during a period of relatively rapid transpiration. Anatomical regions of the root could be differentiated with a spatia ... Full text Link to item Cite

Magnetic resonance microscopy of the rat thorax and abdomen.

Journal Article Invest Radiol · November 1986 With magnetic resonance (MR) microscopy, high-resolution volumetric imaging (3DFT) of small animals is possible. Although these techniques are suitable for imaging the head and other small stationary objects, breathing and cardiac motion degrade the qualit ... Full text Link to item Cite

Three-dimensional magnetic resonance microscopy of the developing chick embryo.

Journal Article Invest Radiol · October 1986 Magnetic resonance imaging microscopy was performed on live chick embryos. A combination of high gradient strength (0.47 mT/cm), special purpose radiofrequency coils and 3-dimensional Fourier imaging was used to obtain images with effective thickness of 1. ... Full text Link to item Cite

MRI MICROSCOPY OF THE DEVELOPING CHICK-EMBRYO

Journal Article INVESTIGATIVE RADIOLOGY · September 1, 1986 Link to item Cite

3-DIMENSIONAL MRI MICROSCOPY OF THE RAT-BRAIN

Journal Article INVESTIGATIVE RADIOLOGY · September 1, 1986 Link to item Cite

VARIANT ANGLE GRADIENT REFOCUSING IN 3-DIMENSIONAL MRI MICROSCOPY

Journal Article INVESTIGATIVE RADIOLOGY · September 1, 1986 Link to item Cite

53 MAGNETIC RESONANCE IMAGING OF THE RAT THORAX AND ABDOMEN

Journal Article Investigative Radiology · September 1986 Full text Cite

MRI of brain iron.

Journal Article AJR Am J Roentgenol · July 1986 A prominently decreased signal intensity in the globus pallidum, reticular substantia nigra, red nucleus, and dentate nucleus was routinely noted in 150 consecutive individuals on T2-weighted images (SE 2000/100) using a high field strength (1.5 T)MR syste ... Full text Link to item Cite

MR IMAGING AND PERLS STAIN OF BASAL GANGLIA IRON WITH NORMAL AGING

Journal Article AMERICAN JOURNAL OF NEURORADIOLOGY · May 1, 1986 Link to item Cite

MAGNETIC-RESONANCE-IMAGING OF BRAIN IRON

Journal Article AMERICAN JOURNAL OF NEURORADIOLOGY · May 1, 1986 Link to item Cite

Parkinson plus syndrome: diagnosis using high field MR imaging of brain iron.

Journal Article Radiology · May 1986 The distribution of iron in the brain was analyzed using high field strength (1.5 T) magnetic resonance (MR) imaging in 14 healthy control individuals and six patients with Parkinson plus syndromes (multisystem atrophy and progressive supranuclear palsy) w ... Full text Link to item Cite

Histogram-directed processing of digital chest images.

Journal Article Invest Radiol · March 1986 One of the potential advantages of digital chest imaging is the ability to process these images. However, such processing, when uniformly applied to the entire image, is often unsatisfactory due to the different processing requirements of lung field and me ... Full text Link to item Cite

Nuclear magnetic resonance imaging at microscopic resolution

Journal Article Journal of Magnetic Resonance (1969) · 1986 Featured Publication Resolution limits in NMR imaging are imposed by bandwidth considerations, available magnetic gradients for spatial encoding, and signal to noise. This work reports modification of a clinical NMR imaging device with picture elements of 500 × 500 × 5000 μm t ... Cite

Magnetic resonance microscopy in neurologic models.

Journal Article Acta Radiol Suppl · 1986 Magnetic resonance imaging techniques have been developed to permit imaging with slice thickness less than 1 mm and pixels of 50 x 50 microns. Special purpose gradient and radiofrequency coils and three-dimensional imaging techniques enable acquisition of ... Link to item Cite

MR "microscopy" of the rat thorax.

Journal Article J Comput Assist Tomogr · 1986 High resolution images can be obtained from anywhere in the body of small animals with magnetic resonance combined with cardiac gating and scan synchronous ventilation. We used these methods to examine the intrathoracic anatomy of the rat. Anesthetized rat ... Full text Link to item Cite

Digital synthesis of lung nodules.

Journal Article Invest Radiol · December 1985 Studies evaluating observer accuracy and visual perception of pulmonary nodules usually are based upon test films obtained from clinical practice in patients with proven pulmonary nodules. Unfortunately, such nodules do not always occur in the optimal size ... Full text Link to item Cite

71 HISTOGRAM DIRECTED PROCESSING OF DIGITAL CHEST IMAGES

Journal Article Investigative Radiology · September 1985 Full text Cite

121 SURFACE COIL MOTION ARTIFACTS IN MR IMAGING

Journal Article Investigative Radiology · September 1985 Full text Cite

105 Optimization of Adaptive Filtration for Digital Chest Imaging

Journal Article Investigative Radiology · September 1985 Full text Cite

Tissue relaxation time: in vivo field dependence.

Journal Article Radiology · September 1985 Relaxation times (T1 and T2) were measured in vivo in mongrel dogs at fields of 0.3, 0.5, 1.0, 1.35, and 1.5 tesla (T). T1 was measured using nine values of inversion time ranging from 10 to 1,280 msec. T2 was measured with a four-point multiple spin-echo ... Full text Link to item Cite

Processing alternatives for digital chest imaging.

Journal Article Radiol Clin North Am · June 1985 Radiographic imaging of the chest remains one of the most important and most challenging problems in radiology. The wide range of information that results from the great variation of radiation behind the lungs compared with that behind the mediastinum crea ... Link to item Cite

EVALUATION OF COMPUTER SYNTHESIZED PULMONARY NODULES

Journal Article INVESTIGATIVE RADIOLOGY · January 1, 1985 Link to item Cite

HIGH-RESOLUTION MRI IMAGING AT 1.5T USING SURFACE COILS

Journal Article JOURNAL OF NUCLEAR MEDICINE · 1985 Cite

AUTOMATED OBSERVER STUDIES ON A DIGITAL CHEST SYSTEM

Journal Article INVESTIGATIVE RADIOLOGY · January 1, 1985 Link to item Cite

PRECISION AND ACCURACY IN THE MEASUREMENT OF T1 ON AN IMAGING-SYSTEM

Journal Article INVESTIGATIVE RADIOLOGY · January 1, 1985 Link to item Cite

Time course and mechanism of alterations in proton relaxation during liver regeneration in the rat.

Journal Article Hepatology · 1985 We studied the proton T1 and T2, water and lipid content of regenerating rat liver from 1 to 7 days after 70% hepatectomy. Liver from normal and sham-operated animals and splenic tissue from all animals were studied as controls. In vivo proton spectroscopy ... Full text Link to item Cite

166. IN VIVO CHEMICAL SHIFT IMAGING OF HYDROGEN

Journal Article Investigative Radiology · September 1984 Full text Cite

129. IN VIVO FIELD DEPENDENCE OF TISSUE RELAXATION TIMES

Journal Article Investigative Radiology · September 1984 Full text Cite

159. A CT EVALUATION OF THREE HEPATOBILIARY CONTRAST AGENTS

Journal Article Investigative Radiology · September 1984 Full text Cite

106. PROGRESS IN ECG-GATED CT

Journal Article Investigative Radiology · September 1984 Full text Cite

194. DIGITAL SYNTHESIS OF LUNG NODULES

Journal Article Investigative Radiology · September 1984 Full text Cite

DESIGN CONSIDERATIONS FOR SMALL ANIMAL IMAGING IN A LARGE BORE MRI SYSTEM

Journal Article INVESTIGATIVE RADIOLOGY · January 1, 1984 Link to item Cite

VARIABLE FIELD STUDIES OF POTENTIAL PARAMAGNETIC NMR CONTRAST AGENTS

Journal Article MAGNETIC RESONANCE IN MEDICINE · 1984 Cite

CAROTID-ARTERY IMAGING BY A 1.5-T MR SYSTEM

Journal Article AMERICAN JOURNAL OF NEURORADIOLOGY · January 1, 1984 Link to item Cite

HIGH-FIELD NMR IMAGING (1.5T) IN A HOSPITAL ENVIRONMENT

Journal Article AMERICAN JOURNAL OF NEURORADIOLOGY · 1984 Cite

A phantom for testing ECG-gated computed tomography of the heart.

Journal Article Invest Radiol · 1984 A mechanical phantom has been built to evaluate electrocardiographically gated computed tomography of the heart. The phantom simulates the heart in terms of cyclic changes in chamber dimensions and wall thickness. Rate and excursion are variable, and the c ... Full text Link to item Cite

Transition metal-chelate complexes as relaxation modifiers in nuclear magnetic resonance.

Journal Article Med Phys · 1984 Studies are reported of relaxation modifiers for use in nuclear magnetic resonance (NMR) imaging systems. Chelate complexes of transition metal salts are under investigation to determine their ability to reduce the spin-lattice relaxation time (T1) of the ... Full text Link to item Cite

A system for digital videodensitometry

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · December 13, 1983 Full text Cite

A survey of digital chest radiography.

Journal Article Radiol Clin North Am · December 1983 The problems of chest radiography as they relate to digital systems are described, the current approaches to these problems are reviewed, and the utility of digital chest radiography is demonstrated. ... Link to item Cite

CONTRAST ENHANCEMENT OF THE LIVER DURING CT

Journal Article Investigative Radiology · July 1983 Full text Cite

High kVp vs. low kVp for T-tube and operative cholangiography.

Journal Article Radiology · March 1983 Based on several considerations, high kVp and high contrast agent concentration should produce better-quality operative and T-tube cholangiograms than the currently recommended low kVp and low contrast agent concentration. To test this theory, two kinds of ... Full text Link to item Cite

The 'optimal' chest radiograph

Journal Article Seminars in Respiratory Medicine · January 1, 1983 Full text Cite

A SYSTEM FOR DIGITAL VIDEODENSITOMETRY

Journal Article AMERICAN JOURNAL OF ROENTGENOLOGY · 1983 Cite

Practical approach to quality assurance in computed tomography

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · December 29, 1982 The goal of tissue characterization via quantitative computed tomography can only be accomplished with careful control of certain parameters. A quality assurance program is described which includes daily measurement of certain essential elements e.g. Houns ... Full text Cite

Gated multiplanar cardiac computed tomography.

Journal Article Radiology · October 1982 Multiplanar reformatting was combined with electrocardiographically gated computed tomography (CT) to provide a three-dimensional assessment of the beating heart of a live dog. Separate systolic and diastolic images were made in transverse, sagittal, coron ... Full text Link to item Cite

Image techniques for multiplanar computed tomography.

Journal Article Radiology · September 1982 Hardware and software options of the GE 8800 CT scanner were analyzed with respect to their effect on image quality for multiplanar images. Phantom studies were undertaken to demonstrate the effect of collimation, thick pixel reconstruction, and interpolat ... Full text Link to item Cite

CONTRAST ENHANCEMENT OF THE HEPATOBILIARY SYSTEM DURING CT

Journal Article Investigative Radiology · July 1982 Full text Cite

HIGH RESOLUTION MULTIPLANAR CT IMAGES OF THE LARYNX

Journal Article Investigative Radiology · July 1982 Full text Cite

Distinguishing benign from malignant pulmonary nodules by computed tomography.

Journal Article Radiology · July 1982 Investigators have been able to distinguish benign pulmonary nodules from malignant ones in about two-thirds of the cases studied by detecting high computed tomography (CT) numbers (attributed to microscopic calcifications) within many benign nodules. This ... Full text Link to item Cite

Low-cost digital subtraction

Journal Article American Journal Of Neuroradiology · 1982 Cite

A PRACTICAL APPROACH TO QUALITY ASSURANCE IN CT

Journal Article AMERICAN JOURNAL OF ROENTGENOLOGY · 1982 Cite

High-resolution multiplanar CT images of the larynx.

Journal Article Invest Radiol · 1982 The standard technique for computed tomographic evaluation of the larynx utilizes 5-mm contiguous transaxial sections. Multiplanar images reformatted with these sections have not been of clinical use. We have evaluated the practicality of utilizing coronal ... Full text Link to item Cite

Low-cost digital subtraction angiography.

Journal Article AJNR Am J Neuroradiol · 1982 Link to item Cite

IMAGING LIMITS IN DIGITAL RADIOGRAPHY

Journal Article Investigative Radiology · September 1981 Full text Cite

AN EVALUATION OF CONTRAST AGENTS FOR CT OF THE HEPATOBILIARY SYSTEM

Journal Article Investigative Radiology · September 1981 Full text Cite

Evaluation of multiplanar imaging capabilities of four current computed tomography (CT) scanners

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · July 16, 1981 Four state of the art CT scanners were evaluated with respect to optimal techniques for multiplanar imaging. The four scanners were a G. E. 8800, Pfizer 0^50, Picker Synerview 600 and Siemens Somatom 2. Patient movement artefacts can be minimized by choice ... Full text Cite

Digital radiography using the quantex ds-20

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · July 16, 1981 The Quantex DS-20 digital image processor has been evaluated as a low cost alternative for digital vascular radiography. The processor is used in conjunction with a conventional remote radiographic/fluoroscopic system with no generator/processor interface ... Full text Cite

Voltage waveform effects on output and penetration of W- and Mo-anode mammographic tubes.

Journal Article Phys Med Biol · March 1981 The output and half-value thickness (HVT) for arbitrary voltage waveforms can be calculated if the variation of both quantities with voltage is known under constant-potential (ripple-free) conditions. An apparatus to study this variation is described. It p ... Full text Link to item Cite

Effect of vertical cassette holder design and construction on scatter-to-primary radiation ratios.

Journal Article Radiology · February 1981 This paper analyzes the contribution to scattered radiation at the film plane by individual components of a conventional wall-mounted cassette holder. With grid technique, scatter from the front panel of the cassette holder is effectively reduced, but cons ... Full text Link to item Cite

DIGITAL RADIOGRAPHY USING THE QUANTEX DS-20

Journal Article AMERICAN JOURNAL OF ROENTGENOLOGY · 1981 Cite

AN EVALUATION OF MULTIPLANAR IMAGING CAPABILITIES OF 4 CURRENT CT SCANNERS

Journal Article AMERICAN JOURNAL OF ROENTGENOLOGY · 1981 Cite

A computed tomographic study of the dog lung during hemorrhagic shock and after resuscitation.

Journal Article Invest Radiol · 1981 A shock model was used to explore the capability of computed tomography (CT) to detect changes in lung density during hypovolemia and after resuscitation. The same level of the lower thorax was scanned repeatedly during base-line, shock (aortic pressure 60 ... Full text Link to item Cite

Electromagnetic emission from visual display units: A non-hazard

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · October 7, 1980 An analysis of the electromagnetic emissions of an IBM Model 32772 visual display unit showed no hazardous levels in any portion of the spectrum. The actual level of emission was measured throughout the spectrum from low frequency radio waves through x-rad ... Full text Cite

Investigation of transmolybdenum fluorescent anodes for mammography

Conference Proceedings of SPIE - The International Society for Optical Engineering · August 18, 1980 Recent work has suggested a new approach to film/screen mammography through the use of transmolybdenum (Z > 42) fluorescent anodes. An experimental rhodium (Z = 45) anode with K emission at 20.0 - 23.2 keV has been compared to a conventional molybdenum ano ... Full text Cite

AN INVESTIGATION OF TRANSMOLYBDENUM FLUORESCENT ANODES FOR MAMMOGRAPHY

Journal Article AMERICAN JOURNAL OF ROENTGENOLOGY · 1980 Cite

Iodine concentration and radiographic density during oral cholecystography

Journal Article Investigative Radiology · January 1, 1980 Full text Cite

PRACTICAL GUIDELINES FOR SPECIMEN RADIOGRAPHY

Journal Article INVESTIGATIVE RADIOLOGY · 1980 Cite

SCATTERED RADIATION FROM THE FILM HOLDER IN CHEST RADIOGRAPHY

Journal Article AMERICAN JOURNAL OF ROENTGENOLOGY · January 1, 1980 Link to item Cite

Simulation of mammographic x-ray spectra.

Journal Article Med Phys · 1980 Attempts to simulate Mo-anode spectra for film mammography by using Mo filters with W-anode tubes have been reported by several workers, and others have generated W-like continua for xeromammographic purposes by heavy Al filtration of Mo-anode tubes. In th ... Full text Link to item Cite

COMPUTERIZED TOMOGRAPHIC STUDY OF THE DOG LUNG DURING HEMORRHAGIC-SHOCK

Journal Article INVESTIGATIVE RADIOLOGY · January 1, 1979 Link to item Cite

An experimental "trans-molybdenum" tube for mammography.

Journal Article Radiology · May 1978 Possible mammographic advantages of "trans-molybdenum" anodes (atomic number greater than ZMo) are decreased dose because the fluorescent radiation is more penetrating, and increased useful output; contrast degradation is known to be tolerable. The output ... Full text Link to item Cite

Simple method of obtaining Si(Li) detector efficiency

Journal Article Nuclear Instruments and Methods · May 1, 1978 The efficiency of a semi-conductor detector is measured by compairing its response with that of an NaI(Tl) detector of known efficiency when both are exposed to the same flux of gamma-excited fluorescent X-rays. The experimental procedure is outlined and c ... Full text Cite

Hepatotrophic factors: implications for diabetes mellitus.

Journal Article Ciba Found Symp · 1977 In view of the importance of insulin in hepatic cell proliferation and regeneration, disturbances might be expected in these processes in diabetics. The relative importnace of insulin replacement given intraportally rather than subcutaneously is discussed. ... Full text Link to item Cite

SPECTROMETRIC STUDIES OF WAVEFORM AND FILTRATION EFFECTS IN MAMMOGRAPHY

Journal Article PHYSICS IN MEDICINE AND BIOLOGY · 1977 Cite

Free radicals formed by exposure of pyrimidine solids to sodium atoms: an electron spin resonance study.

Journal Article Proc Natl Acad Sci U S A · March 1975 Sodium atoms have been deposited on various pyrimidine powders under high vacuum at 77 degrees K and the electron spin resonance spectra of the resulting free radicals have been observed. Generally, the spectra show that the electron of the Na goes into a ... Full text Link to item Cite

Salicylate induced hypoglycaemia: a possible mechanism

Journal Article European Journal of Clinical Investigation · January 1, 1974 Cite