Scholars@Duke
Qingyi Wei

Qingyi Wei

Professor Emeritus in Population Health Sciences
Population Health Sciences
qingyi.wei@duke.edu
103858, GSRB1 Room 3015C, Durham, NC 27710
215 Morris Street, Suite 210, Durham, NC 27701

Selected Publications

Potentially functional variants of PARK7 and DDR2 in ferroptosis-related genes predict survival of non-small cell lung cancer patients.

Journal Article Int J Cancer · September 25, 2024 Ferroptosis, a form of regulated cell death, is characterized by iron-dependent lipid peroxidation. It is recognized increasingly for its pivotal role in both cancer development and the response to cancer treatments. We assessed associations between 370,02 ... Full text Link to item Cite

Potentially functional variants of CHMP4A and PANX1 in the pyroptosis-related pathway predict survival of patients with non-oropharyngeal head and neck squamous cell carcinoma.

Journal Article Mol Carcinog · September 2024 BACKGROUND: Pyroptosis has been implicated in the advancement of various cancers. Triggering pyroptosis within tumors amplifies the immune response, thereby fostering an antitumor immune environment. Nonetheless, few published studies have evaluated associ ... Full text Link to item Cite

Potentially functional variants of ERRFI1 in hypoxia-related genes predict survival of non-small cell lung cancer patients.

Journal Article Cancer Med · August 2024 BACKGROUND: Hypoxia is often involved in tumor microenvironment, and the hypoxia-induced signaling pathways play a key role in aggressive cancer phenotypes, including angiogenesis, immune evasion, and therapy resistance. However, it is unknown what role ge ... Full text Link to item Cite

Functional genetic variants of the disulfidptosis-related INF2 gene predict survival of hepatitis B virus-related hepatocellular carcinoma.

Journal Article Carcinogenesis · April 12, 2024 Disulfidptosis is a novel form of programmed cell death involved in migration and invasion of cancer cells, but few studies investigated the roles of genetic variants in disulfidptosis-related genes in survival of patients with hepatitis B virus (HBV)-rela ... Full text Link to item Cite

TGF-β1 and TGF-βR1 variants are associated with clinical outcomes in smoking-related head and neck cancer patients treated with chemoradiation through modulating microRNA-mediated regulation.

Journal Article Cancer Immunol Immunother · March 30, 2024 TGF-β1 and TGF-βR1 play important roles in immune and inflammatory responses. Genetic variants of TGF-β1 rs1800470 and TGF-βR1 rs334348 have emerged as potentially prognostic biomarkers for HPV-related head and neck cancer, while their prognostic effect on ... Full text Link to item Cite

CYP2A6 Activity and Cigarette Consumption Interact in Smoking-Related Lung Cancer Susceptibility.

Journal Article Cancer Res · February 15, 2024 UNLABELLED: Cigarette smoke, containing both nicotine and carcinogens, causes lung cancer. However, not all smokers develop lung cancer, highlighting the importance of the interaction between host susceptibility and environmental exposure in tumorigenesis. ... Full text Link to item Cite

Impact of HER2-low status for patients with early-stage breast cancer and non-pCR after neoadjuvant chemotherapy: a National Cancer Database Analysis.

Journal Article Breast Cancer Res Treat · February 2024 PURPOSE: To investigate potential differences in pathological complete response (pCR) rates and overall survival (OS) between HER2-low and HER2-zero patients with early-stage hormone receptor (HR)-positive and triple-negative breast cancer (TNBC), in the n ... Full text Open Access Link to item Cite

Impact of primary tumor resection and metastasectomy among gastroentero-pancreatic neuroendocrine tumors with liver metastases only on survival.

Journal Article HPB (Oxford) · January 2024 BACKGROUND: Despite recommendations for primary tumor resection (PTR) with or without liver resection (LR) in the patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and isolated liver metastases, there are conflicting data for their impa ... Full text Open Access Link to item Cite

Ethnic differences of genetic risk and smoking in lung cancer: two prospective cohort studies.

Journal Article Int J Epidemiol · December 25, 2023 BACKGROUND: The role of genetic background underlying the disparity of relative risk of smoking and lung cancer between European populations and East Asians remains unclear. METHODS: To assess the role of ethnic differences in genetic factors associated wi ... Full text Link to item Cite

Appropriate dose of regorafenib based on body weight of colorectal cancer patients: a retrospective cohort study.

Journal Article BMC Cancer · December 21, 2023 PURPOSE: Previous randomized studies have shown a survival benefit of using regorafenib but a high rate of adverse events in unresectable colorectal cancer patients. To reduce these adverse events and improve the tolerability, we examined the appropriate d ... Full text Open Access Link to item Cite

Impact of surgical approach on short- and long-term outcomes in gastroenteropancreatic neuroendocrine carcinomas.

Journal Article HPB (Oxford) · October 2023 BACKGROUND: Literature is lacking on the impact of advancements in minimally invasive surgery (MIS) on outcomes for patients with gastroenteropancreatic neuroendocrine carcinomas (GEP-NECs). Herein, we compared perioperative and oncologic outcomes among pa ... Full text Open Access Link to item Cite

Functional Genetic Variants in TGFβ1 and TGFβR1 in miRNA-Binding Sites Predict Outcomes in Patients with HPV-positive Oropharyngeal Squamous Cell Carcinoma.

Journal Article Clin Cancer Res · August 15, 2023 PURPOSE: TGFβ1 and TGFβ receptor 1 (TGFβR1) participate in regulation of the host's immune system and inflammatory responses and may serve as prognostic biomarkers for human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC). EXP ... Full text Link to item Cite

GWAS-identified telomere length associated genetic variants predict risk of recurrence of HPV-positive oropharyngeal cancer after definitive radiotherapy.

Journal Article EBioMedicine · August 2023 BACKGROUND: Lymphocyte telomere length (LTL)-related genetic variants may modulate LTL and affect recurrence of squamous cell carcinoma of the oropharynx (SCCOP). METHODS: A total of 1013 patients with incident SCCOP were recruited and genotyped for 16 gen ... Full text Link to item Cite

Primary tumor resection improves survival of gastrointestinal neuroendocrine carcinoma patients with nonresected liver metastases.

Journal Article J Surg Oncol · May 2023 BACKGROUND: The role of primary tumor resection (PTR) in the survival of gastrointestinal neuroendocrine carcinoma (GI-NEC) patients with liver metastases only remains poorly defined. Therefore, we investigated the impact of PTR on the survival of GI-NEC p ... Full text Open Access Link to item Cite

Development, validation, and evaluation of a risk assessment tool for personalized screening of gastric cancer in Chinese populations.

Journal Article BMC Med · April 27, 2023 BACKGROUND: Effective risk prediction models are lacking for personalized endoscopic screening of gastric cancer (GC). We aimed to develop, validate, and evaluate a questionnaire-based GC risk assessment tool for risk prediction and stratification in the C ... Full text Open Access Link to item Cite

Rare variants confer shared susceptibility to gastrointestinal tract cancer risk.

Journal Article Front Oncol · 2023 BACKGROUND: Cancers arising within the gastrointestinal tract are complex disorders involving genetic events that cause the conversion of normal tissue to premalignant lesions and malignancy. Shared genetic features are reported in epithelial-based gastroi ... Full text Link to item Cite

Potentially functional genetic variants of the notch signaling pathway genes predict survival of Chinese patients with esophageal squamous cell carcinoma.

Journal Article J Gene Med · October 2022 BACKGROUND: The Notch signaling pathway is involved in the progression of esophageal squamous cell carcinoma (ESCC), although the roles of single nucleotide polymorphisms (SNPs) of the Notch signaling pathway genes in the process remain unknown. METHODS: T ... Full text Link to item Cite

Potentially functional genetic variants of VAV2 and PSMA4 in the immune-activation pathway and non-small cell lung cancer survival.

Journal Article J Gene Med · October 2022 BACKGROUND: Lung cancer has the highest mortality among cancers, represented by a low 5-year survival rate. The function of the immune system has a profound influence on the development and progression of lung cancer. Thus genetic variants of the immune-re ... Full text Link to item Cite

Genetic variants in CYP2B6 and HSD17B12 associated with risk of squamous cell carcinoma of the head and neck.

Journal Article Int J Cancer · August 15, 2022 Polycyclic aromatic hydrocarbons (PAH) and tobacco-specific nitrosamines (TSNA) metabolism-related genes play an important role in the development of cancers. We assessed the associations of genetic variants in genes involved in the metabolism of PAHs and ... Full text Link to item Cite

Genetic variants in DDO and PEX5L in peroxisome-related pathways predict non-small cell lung cancer survival.

Journal Article Mol Carcinog · July 2022 Peroxisomes play a role in lipid metabolism and regulation of reactive oxygen species, but its role in development and progression of non-small cell lung cancer (NSCLC) is not well understood. Here, we investigated the associations between 9708 single-nucl ... Full text Open Access Link to item Cite

Deciphering associations between three RNA splicing-related genetic variants and lung cancer risk.

Journal Article NPJ Precis Oncol · June 30, 2022 Limited efforts have been made in assessing the effect of genome-wide profiling of RNA splicing-related variation on lung cancer risk. In the present study, we first identified RNA splicing-related genetic variants linked to lung cancer in a genome-wide pr ... Full text Link to item Cite

Single nucleotide polymorphisms in FOXP1 and RORA of the lymphocyte activation-related pathway affect survival of lung cancer patients.

Journal Article Transl Lung Cancer Res · May 2022 BACKGROUND: Lymphocyte activation is part of a complex microenvironment that affects the development and progression of solid tumors. The present study analyzed the associations between genetic variants in lymphocyte activation-related genes and survival o ... Full text Open Access Link to item Cite

A pleiotropic ATM variant (rs1800057 C>G) is associated with risk of multiple cancers.

Journal Article Carcinogenesis · February 11, 2022 ATM (ataxia-telangiectasia mutated) is an important cell-cycle checkpoint kinase required for cellular response to DNA damage. Activated by DNA double strand breaks, ATM regulates the activities of many downstream proteins involved in various carcinogenic ... Full text Open Access Link to item Cite

A Southeast Asian collaborative Delphi consensus on surveying risk factors for head and neck cancer screening and prevention.

Journal Article Glob Surg · 2022 The objective of this study was to determine high value questions for early detection and prevention of head and neck cancer by querying content experts on patient risk factors relevant to local communities in Southeast Asia (i.e., Vietnam, Laos, China, an ... Open Access Link to item Cite

Genome-wide association and functional interrogation identified a variant at 3p26.1 modulating ovarian cancer survival among Chinese women.

Journal Article Cell Discov · December 21, 2021 Ovarian cancer survival varies considerably among patients, to which germline variation may also contribute in addition to mutational signatures. To identify genetic markers modulating ovarian cancer outcome, we performed a genome-wide association study in ... Full text Link to item Cite

Potentially functional variants of ERAP1, PSMF1 and NCF2 in the MHC-I-related pathway predict non-small cell lung cancer survival.

Journal Article Cancer Immunol Immunother · October 2021 BACKGROUND: Cellular immunity against tumor cells is highly dependent on antigen presentation by major histocompatibility complex class I (MHC-I) molecules. However, few published studies have investigated associations between functional variants of MHC-I- ... Full text Open Access Link to item Cite

Association of genetic variants of FBXO32 and FOXO6 in the FOXO pathway with breast cancer risk.

Journal Article Mol Carcinog · October 2021 Forkhead box class O (FOXO) transcription factors play a pivotal role in regulating a variety of biological processes, including organismal development, cell signaling, cell metabolism, and tumorigenesis. Therefore, we hypothesize that genetic variants in ... Full text Open Access Link to item Cite

Genetic variants of SDCCAG8 and MAGI2 in mitosis-related pathway genes are independent predictors of cutaneous melanoma-specific survival.

Journal Article Cancer Sci · October 2021 Mitosis is a prognostic factor for cutaneous melanoma (CM), but accurate mitosis detection in CM tissues is difficult. Therefore, the 8th Edition of the American Joint Committee on Cancer staging system has removed the mitotic rate as a category criterion ... Full text Open Access Link to item Cite

Genetic variants of CHEK1, PRIM2 and CDK6 in the mitotic phase-related pathway are associated with nonsmall cell lung cancer survival.

Journal Article Int J Cancer · September 15, 2021 The mitotic phase is a vital step in cell division and may be involved in cancer progression, but it remains unclear whether genetic variants in mitotic phase-related pathways genes impact the survival of these patients. Here, we investigated associations ... Full text Open Access Link to item Cite

Genetic Risk for Overall Cancer and the Benefit of Adherence to a Healthy Lifestyle.

Journal Article Cancer Res · September 1, 2021 Cancer site-specific polygenic risk scores (PRS) effectively identify individuals at high risk of individual cancers, but the effectiveness of PRS on overall cancer risk assessment and the extent to which a high genetic risk of overall cancer can be offset ... Full text Link to item Cite

Potentially functional variants of HBEGF and ITPR3 in GnRH signaling pathway genes predict survival of non-small cell lung cancer patients.

Journal Article Transl Res · July 2021 The gonadotropin-releasing hormone (GnRH) signaling pathway controls reproductive functions and cancer growth and progression. However, few studies investigated roles of genetic variants of GnRH pathway genes in survival of patients with non-small cell lun ... Full text Open Access Link to item Cite

Novel functional variants in the Notch pathway and survival of Chinese colorectal cancer.

Journal Article Int J Cancer · July 1, 2021 Notch signaling pathway plays crucial roles in progression of colorectal cancer (CRC), likely affecting overall survival (OS). In a two-stage survival analysis of 1116 CRC patients in East China, we found that one locus at MINAR1 out of 133 genes in the No ... Full text Link to item Cite

Association of genetic variants of TMEM135 and PEX5 in the peroxisome pathway with cutaneous melanoma-specific survival.

Journal Article Ann Transl Med · March 2021 BACKGROUND: Peroxisomes are ubiquitous and dynamic organelles that are involved in the metabolism of reactive oxygen species (ROS) and lipids. However, whether genetic variants in the peroxisome pathway genes are associated with survival in patients with m ... Full text Open Access Link to item Cite

Genetic variants of DOCK2, EPHB1 and VAV2 in the natural killer cell-related pathway are associated with non-small cell lung cancer survival.

Journal Article Am J Cancer Res · 2021 Although natural killer (NK) cells are a known major player in anti-tumor immunity, the effect of genetic variation in NK-associated genes on survival in patients with non-small cell lung cancer (NSCLC) remains unknown. Here, in 1,185 with NSCLC cases of a ... Open Access Link to item Cite

Association of pretreatment body mass index with risk of head and neck cancer: a large single-center study.

Journal Article Am J Cancer Res · 2021 Smoking and alcohol exposure continue to be the dominant risk factors for the development of head and neck squamous cell carcinoma (SCCHN) worldwide. Moreover, human papillomavirus (HPV) is associated with SCCHN, particularly SCC of the oropharynx (SCCOP). ... Link to item Cite

Genetic variants of EML1 and HIST1H4E in myeloid cell-related pathway genes independently predict cutaneous melanoma-specific survival.

Journal Article Am J Cancer Res · 2021 UNLABELLED: Both in vivo and in vitro evidence has supported a key role of myeloid cells in immune suppression in melanoma and in promoting melanocytic metastases. Some single-nucleotide polymorphisms (SNPs) have been shown to predict cutaneous melanoma-sp ... Link to item Cite

Genetic Variants of CLPP and M1AP Are Associated With Risk of Non-Small Cell Lung Cancer.

Journal Article Front Oncol · 2021 BACKGROUND: Single nucleotide polymorphisms (SNPs) are often associated with distinct phenotypes in cancer. The present study investigated associations of cancer risk and outcomes with SNPs discovered by whole exome sequencing of normal lung tissue DNA of ... Full text Link to item Cite

Genetic Variants of CLEC4E and BIRC3 in Damage-Associated Molecular Patterns-Related Pathway Genes Predict Non-Small Cell Lung Cancer Survival.

Journal Article Front Oncol · 2021 Accumulating evidence supports a role of various damage-associated molecular patterns (DAMPs) in progression of lung cancer, but roles of genetic variants of the DAMPs-related pathway genes in lung cancer survival remain unknown. We investigated associatio ... Full text Open Access Link to item Cite

Associations between genetic variants of KIF5B, FMN1, and MGAT3 in the cadherin pathway and pancreatic cancer risk.

Journal Article Cancer Med · December 2020 Because the cadherin-mediated signaling pathway promotes cancer progression, we assessed associations between genetic variants in 109 cadherin-related genes and risk of pancreatic cancer (PanC) by using genotyping data from publically available genome-wide ... Full text Open Access Link to item Cite

Genetic variation associated with childhood and adult stature and risk of MYCN-amplified neuroblastoma.

Journal Article Cancer Med · November 2020 BACKGROUND: Neuroblastoma is the most common pediatric solid tumor. MYCN-amplification is an important negative prognostic indicator and inherited genetic contributions to risk are incompletely understood. Genetic determinants of stature increase risk of s ... Full text Open Access Link to item Cite

Genetic variants in the folate metabolic pathway genes predict cutaneous melanoma-specific survival.

Journal Article Br J Dermatol · October 2020 BACKGROUND: Folate metabolism plays an important role in DNA methylation and nucleic acid synthesis and thus may function as a regulatory factor in cancer development. Genome-wide association studies (GWASs) have identified some single-nucleotide polymorph ... Full text Open Access Link to item Cite

Genetic variants in the human leukocyte antigen region and survival of Chinese patients with non-small cell lung carcinoma.

Journal Article Carcinogenesis · September 24, 2020 Human leukocyte antigen (HLA) is highly polymorphic, driving antigen presentation, complement cascade and leukocyte maturation against cancer cells. Therefore, we extracted genotyping data in the HLA region from an ongoing Chinese genome-wide association s ... Full text Link to item Cite

Potentially functional variants in nucleotide excision repair pathway genes predict platinum treatment response of Chinese ovarian cancer patients.

Journal Article Carcinogenesis · September 24, 2020 Acquired platinum resistance impedes successful treatment of epithelial ovarian cancer (EOC), and this resistance may be associated with inherited DNA damage-repair response. In the present study, we performed a two-phase analysis to assess associations be ... Full text Link to item Cite

Potentially functional genetic variants in PLIN2, SULT2A1 and UGT1A9 genes of the ketone pathway and survival of nonsmall cell lung cancer.

Journal Article Int J Cancer · September 15, 2020 The ketone metabolism pathway is a principle procedure in physiological homeostasis and induces cancer cells to switch between glycolysis and oxidative phosphorylation for energy production. We conducted a two-phase analysis for associations between geneti ... Full text Open Access Link to item Cite

Genetic variants in TKT and DERA in the nicotinamide adenine dinucleotide phosphate pathway predict melanoma survival.

Journal Article Eur J Cancer · September 2020 BACKGROUND: Cutaneous melanoma (CM) is the most lethal type of skin cancers. Nicotinamide adenine dinucleotide phosphate (NADPH) plays an important role in anabolic reactions and tumorigenesis, but many genes are involved in the NADPH system. METHODS: We u ... Full text Open Access Link to item Cite

Genetic variants of the peroxisome proliferator-activated receptor (PPAR) signaling pathway genes and risk of pancreatic cancer.

Journal Article Mol Carcinog · August 2020 Because the peroxisome proliferator-activated receptor (PPAR) signaling pathway is involved in development and progression of pancreatic cancer, we investigated associations between genetic variants of the PPAR pathway genes and pancreatic cancer risk by u ... Full text Open Access Link to item Cite

Novel Variants of ELP2 and PIAS1 in the Interferon Gamma Signaling Pathway Are Associated with Non-Small Cell Lung Cancer Survival.

Journal Article Cancer Epidemiol Biomarkers Prev · August 2020 BACKGROUND: IFNγ is a pleiotropic cytokine that plays critical immunomodulatory roles in intercellular communication in innate and adaptive immune responses. Despite recognition of IFNγ signaling effects on host defense against viral infection and its util ... Full text Open Access Link to item Cite

Novel genetic variants in KIF16B and NEDD4L in the endosome-related genes are associated with nonsmall cell lung cancer survival.

Journal Article Int J Cancer · July 15, 2020 The endosome is a membrane-bound organ inside most eukaryotic cells, playing an important role in adaptive immunity by delivering endocytosed antigens to both MHC class I and II pathways. Here, by analyzing genotyping data from two published genome-wide as ... Full text Open Access Link to item Cite

A Genome-Wide Association Study Identifies Two Novel Susceptible Regions for Squamous Cell Carcinoma of the Head and Neck.

Journal Article Cancer Res · June 15, 2020 To identify genetic variants for risk of squamous cell carcinoma of the head and neck (SCCHN), we conducted a two-phase genome-wide association study consisting of 7,858,089 SNPs in 2,171 cases and 4,493 controls of non-Hispanic white, of which, 434,839 ty ... Full text Link to item Cite

APOB Genotypes and CDH13 Haplotypes in the Cholesterol-Related Pathway Genes Predict Non-Small Cell Lung Cancer Survival.

Journal Article Cancer Epidemiol Biomarkers Prev · June 2020 BACKGROUND: Several oncogenic signals are involved in the synthesis, metabolism, transportation, and modulation of cholesterol. However, the roles of genetic variants of the cholesterol pathway genes in cancer survival remain unclear. METHODS: We investiga ... Full text Open Access Link to item Cite

Novel genetic variants in genes of the Fc gamma receptor-mediated phagocytosis pathway predict non-small cell lung cancer survival.

Journal Article Transl Lung Cancer Res · June 2020 BACKGROUND: Both antibody-dependent cellular cytotoxicity and phagocytosis activate innate immunity, and the Fc gamma receptor (FCGR)-mediated phagocytosis is an integral part of the process. We assessed associations between single-nucleotide polymorphisms ... Full text Open Access Link to item Cite

Differential microRNA expression profiles associated with microsatellite status reveal possible epigenetic regulation of microsatellite instability in gastric adenocarcinoma.

Journal Article Ann Transl Med · April 2020 BACKGROUND: Although microsatellite instability (MSI) is a powerful predictive biomarker for the efficacy of immunotherapy, the mechanism of MSI in sporadic gastrointestinal cancer is not fully understood. However, epigenetics, particularly microRNAs, has ... Full text Link to item Cite

Novel Genetic Variants of ALG6 and GALNTL4 of the Glycosylation Pathway Predict Cutaneous Melanoma-Specific Survival.

Journal Article Cancers (Basel) · January 24, 2020 Because aberrant glycosylation is known to play a role in the progression of melanoma, we hypothesize that genetic variants of glycosylation pathway genes are associated with the survival of cutaneous melanoma (CM) patients. To test this hypothesis, we use ... Full text Open Access Link to item Cite

Common genetic variation and risk of osteosarcoma in a multi-ethnic pediatric and adolescent population.

Journal Article Bone · January 2020 Osteosarcoma, a malignant primary bone tumor most commonly diagnosed in children and adolescents, has a poorly understood genetic etiology. Genome-wide association studies (GWAS) and candidate-gene analyses have identified putative risk variants in subject ... Full text Link to item Cite

The Rare Variant rs35356162 in UHRF1BP1 Increases Bladder Cancer Risk in Han Chinese Population.

Journal Article Front Oncol · 2020 Background: Seventeen loci have been found to be associated with bladder cancer risk by genome-wide association studies (GWAS) in European population. However, little is known about contribution of low-frequency and rare variants to bladder cancer suscepti ... Full text Open Access Link to item Cite

Novel genetic variants of KIR3DL2 and PVR involved in immunoregulatory interactions are associated with non-small cell lung cancer survival.

Journal Article Am J Cancer Res · 2020 Immunoregulatory interactions play a pivotal role in immune surveillance, recognition, and killing, particularly its internal pathway, likely playing an important role in immune escape. By using two genotyping datasets, one from the Prostate, Lung, Colorec ... Open Access Link to item Cite

Variants in SNAI1, AMDHD1 and CUBN in vitamin D pathway genes are associated with breast cancer risk: a large-scale analysis of 14 GWASs in the DRIVE study.

Journal Article Am J Cancer Res · 2020 Vitamin D has a potential anticarcinogenic role, possibly through regulation of cell proliferation and differentiation, stimulation of apoptosis, immune modulation and regulation of estrogen receptor levels. Because breast cancer (BC) risk varies among ind ... Open Access Link to item Cite

Associations of novel variants in PIK3C3, INSR and MAP3K4 of the ATM pathway genes with pancreatic cancer risk.

Journal Article Am J Cancer Res · 2020 The ATM serine/threonine kinase (ATM) pathway plays important roles in pancreatic cancer (PanC) development and progression, but the roles of genetic variants of the genes in this pathway in the etiology of PanC are unknown. In the present study, we assess ... Open Access Link to item Cite

Novel genetic variants of SYK and ITGA1 related lymphangiogenesis signaling pathway predict non-small cell lung cancer survival.

Journal Article Am J Cancer Res · 2020 Although lymphangiogenesis is a vital step in lung cancer metastasis, the association between lymphangiogenesis and non-small cell lung cancer (NSCLC) survival remains unclear. Since single-nucleotide polymorphisms (SNPs) have been reported to predict NSCL ... Open Access Link to item Cite

Genetic variants of BIRC3 and NRG1 in the NLRP3 inflammasome pathway are associated with non-small cell lung cancer survival.

Journal Article Am J Cancer Res · 2020 The nod-like receptor protein 3 (NLRP3) is one of the most characterized inflammasomes, and its genetic variation and functional dysregulation are involved in pathogenesis of several cancers. To systematically evaluate the role of NLRP3 in predicting outco ... Open Access Link to item Cite

Functional genetic variants of CTNNBIP1 predict platinum treatment response of Chinese epithelial ovarian cancer patients.

Journal Article J Cancer · 2020 Chemotherapy resistance remains a blockade for successful treatment and longer overall survival of patients with epithelial ovarian cancer (EOC). CTNNBIP1 is an inhibitor of β-catenin that is a chemotherapeutic target for EOC treatment. In the present stud ... Full text Link to item Cite

Novel genetic variants of PIP5K1C and MVB12B of the endosome-related pathway predict cutaneous melanoma-specific survival.

Journal Article Am J Cancer Res · 2020 Endosomes regulate cell polarity, adhesion, signaling, immunity, and tumor progression, which may influence cancer outcomes. Here we evaluated associations between 36,068 genetic variants of 228 endosome-related pathway genes and cutaneous melanoma disease ... Open Access Link to item Cite

A genetic variant within MDM4 3'UTR miRNA binding site is associated with HPV16-positive tumors and survival of oropharyngeal cancer.

Journal Article Mol Carcinog · December 2019 As mouse double minute 4 (MDM4) and HPV16 E6 oncoproteins play important roles in inhibition of p53 activity, a functional polymorphism (rs4245739) in the 3' untranslated regions of MDM4 targeted by microRNA-191 may alter its expression level or functional ... Full text Link to item Cite

Genetic variants in ELOVL2 and HSD17B12 predict melanoma-specific survival.

Journal Article Int J Cancer · November 15, 2019 Fatty acids play a key role in cellular bioenergetics, membrane biosynthesis and intracellular signaling processes and thus may be involved in cancer development and progression. In the present study, we comprehensively assessed associations of 14,522 comm ... Full text Open Access Link to item Cite

Role of Immune Response, Inflammation, and Tumor Immune Response-Related Cytokines/Chemokines in Melanoma Progression.

Journal Article J Invest Dermatol · November 2019 To investigate the role of tumor cytokines/chemokines in melanoma immune response, we estimated the proportions of immune cell subsets in melanoma tumors from The Cancer Genome Atlas, followed by evaluation of the association between cytokine/chemokine exp ... Full text Link to item Cite

Genetic variants in glutamine metabolic pathway genes predict cutaneous melanoma-specific survival.

Journal Article Mol Carcinog · November 2019 Glutamine dependence is a unique metabolic defect seen in cutaneous melanoma (CM), directly influencing the treatment and prognosis. Here, we investigated the associations between 6025 common single-nucleotide polymorphisms (SNPs) in 77 glutamine metabolic ... Full text Link to item Cite

Functional genetic variants of RUVBL1 predict overall survival of Chinese patients with epithelial ovarian cancer.

Journal Article Carcinogenesis · October 16, 2019 To date, the 5-year overall survival of epithelial ovarian cancer (EOC) remains poor. Because studies suggest that RUVBL1 may be a chemotherapeutic target for the treatment of cancer, in this study, therefore, we investigated the role of potentially functi ... Full text Link to item Cite

Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations.

Journal Article Lancet Respir Med · October 2019 BACKGROUND: Genetic variation has an important role in the development of non-small-cell lung cancer (NSCLC). However, genetic factors for lung cancer have not been fully identified, especially in Chinese populations, which limits the use of existing polyg ... Full text Link to item Cite

Genetic variants of genes in the NER pathway associated with risk of breast cancer: A large-scale analysis of 14 published GWAS datasets in the DRIVE study.

Journal Article Int J Cancer · September 1, 2019 A recent hypothesis-free pathway-level analysis of genome-wide association study (GWAS) datasets suggested that the overall genetic variation measured by single nucleotide polymorphisms (SNPs) in the nucleotide excision repair (NER) pathway genes was assoc ... Full text Open Access Link to item Cite

Genetic variants in RUNX3, AMD1 and MSRA in the methionine metabolic pathway and survival in nonsmall cell lung cancer patients.

Journal Article Int J Cancer · August 1, 2019 Abnormal methionine dependence in cancer cells has led to methionine restriction as a potential therapeutic strategy. We hypothesized that genetic variants involved in methionine-metabolic genes are associated with survival in nonsmall cell lung cancer (NS ... Full text Open Access Link to item Cite

Genetic variants in the liver kinase B1-AMP-activated protein kinase pathway genes and pancreatic cancer risk.

Journal Article Mol Carcinog · August 2019 The liver kinase B1-AMP-activated protein kinase (LKB1-AMPK) pathway has been identified as a new target for cancer therapy, because it controls the glucose and lipid metabolism in response to alterations in nutrients and intracellular energy levels. In th ... Full text Open Access Link to item Cite

Lymphocyte telomere length predicts clinical outcomes of HPV-positive oropharyngeal cancer patients after definitive radiotherapy.

Journal Article Carcinogenesis · July 6, 2019 Because lymphocyte telomere length (LTL) plays critical roles in the maintenance of genomic stability and integrity, LTL thus may influence the etiology and prognosis of squamous cell carcinoma of the oropharynx (SCCOP). However, given the association betw ... Full text Open Access Link to item Cite

Potentially functional genetic variants in the TNF/TNFR signaling pathway genes predict survival of patients with non-small cell lung cancer in the PLCO cancer screening trial.

Journal Article Mol Carcinog · July 2019 The tumor necrosis factor (TNF)/TNF receptor (TNFR) pathway is known to influence survival of patients with cancer. We hypothesize that single nucleotide polymorphisms (SNPs) in the TNF/TNFR pathway genes related to apoptosis are associated with survival o ... Full text Open Access Link to item Cite

Potential functional variants in SMC2 and TP53 in the AURORA pathway genes and risk of pancreatic cancer.

Journal Article Carcinogenesis · June 10, 2019 The AURORA pathway participates in mitosis and cell division, and alterations in mitosis and cell division can lead to carcinogenesis. Therefore, genetic variants in the AURORA pathway genes may be associated with susceptibility to pancreatic cancer. To te ... Full text Open Access Link to item Cite

Three novel genetic variants in NRF2 signaling pathway genes are associated with pancreatic cancer risk.

Journal Article Cancer Sci · June 2019 Pancreatic cancer (PanC) is one of the most lethal solid malignancies, and metastatic PanC is often present at the time of diagnosis. Although several high- and low-penetrance genes have been implicated in PanC, their roles in carcinogenesis remain only pa ... Full text Open Access Link to item Cite

Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women.

Journal Article Gynecol Oncol · May 2019 OBJECTIVE: Genome-wide association studies (GWASs) for epithelial ovarian cancer (EOC) have focused largely on populations of European ancestry. We aimed to identify common germline variants associated with EOC risk in Asian women. METHODS: Genotyping was ... Full text Open Access Link to item Cite

Genetic variants in the calcium signaling pathway genes are associated with cutaneous melanoma-specific survival.

Journal Article Carcinogenesis · April 29, 2019 Remodeling or deregulation of the calcium signaling pathway is a relevant hallmark of cancer including cutaneous melanoma (CM). In this study, using data from a published genome-wide association study (GWAS) from The University of Texas M.D. Anderson Cance ... Full text Open Access Link to item Cite

Potentially functional genetic variants in the complement-related immunity gene-set are associated with non-small cell lung cancer survival.

Journal Article Int J Cancer · April 15, 2019 The complement system plays an important role in the innate and adaptive immunity, complement components mediate tumor cytolysis of antibody-based immunotherapy, and complement activation in the tumor microenvironment may promote tumor progression or inhib ... Full text Open Access Link to item Cite

Functional variant of MTOR rs2536 and survival of Chinese gastric cancer patients.

Journal Article Int J Cancer · January 15, 2019 We previously reported that some single nucleotide polymorphisms (SNPs) of candidate genes involved in the MTOR complex1 (MTORC1) were associated with risk of gastric cancer (GCa). In the present study, we further evaluated associations of eight potentiall ... Full text Open Access Link to item Cite

Genetic variant of IRAK2 in the toll-like receptor signaling pathway and survival of non-small cell lung cancer.

Journal Article Int J Cancer · November 15, 2018 The toll-like receptor (TLR) signaling pathway plays an important role in the innate immune responses and antigen-specific acquired immunity. Aberrant activation of the TLR pathway has a significant impact on carcinogenesis or tumor progression. Therefore, ... Full text Open Access Link to item Cite

Genetic variants in nucleotide excision repair pathway predict survival of esophageal squamous cell cancer patients receiving platinum-based chemotherapy.

Journal Article Mol Carcinog · November 2018 The benefits of platinum-based chemotherapy (PBC) on survival of esophageal squamous cell carcinoma (ESCC) patients are inexplicit due to the varied therapeutic effects. Nucleotide excision repair (NER) pathway plays a vital role in removing platinum-DNA a ... Full text Open Access Link to item Cite

Variants in Notch signalling pathway genes, PSEN1 and MAML2, predict overall survival in Chinese patients with epithelial ovarian cancer.

Journal Article J Cell Mol Med · October 2018 To identify genetic variants in Notch signalling pathway genes that may predict survival of Han Chinese patients with epithelial ovarian cancer (EOC), we analysed a total of 1273 single nucleotide polymorphisms (SNPs) within 75 Notch genes in 480 patients ... Full text Open Access Link to item Cite

A TGF-β1 genetic variant at the miRNA187 binding site significantly modifies risk of HPV16-associated oropharyngeal cancer.

Journal Article Int J Cancer · September 15, 2018 TGF-β1rs1982073 polymorphism at the miRNA-187 binding site may alter TGF-β1 expression and function, and thereby this polymorphism (genotype CT/CC) increases cancer susceptibility. HPV16 L1 seropositivity is associated with the risk of oral squamous cell c ... Full text Open Access Link to item Cite

Genetic determinants of childhood and adult height associated with osteosarcoma risk.

Journal Article Cancer · September 15, 2018 BACKGROUND: Although increased height has been associated with osteosarcoma risk in previous epidemiologic studies, to the authors' knowledge the relative contribution of stature during different developmental timepoints remains unclear. Furthermore, the q ... Full text Open Access Link to item Cite

Single-nucleotide polymorphisms of stemness genes predicted to regulate RNA splicing, microRNA and oncogenic signaling are associated with prostate cancer survival.

Journal Article Carcinogenesis · July 3, 2018 Prostate cancer (PCa) is a clinically and molecularly heterogeneous disease, with variation in outcomes only partially predicted by grade and stage. Additional tools to distinguish indolent from aggressive disease are needed. Phenotypic characteristics of ... Full text Open Access Link to item Cite

Genetic variants in RORA and DNMT1 associated with cutaneous melanoma survival.

Journal Article Int J Cancer · June 1, 2018 Cutaneous melanoma (CM) is considered as a steroid hormone-related malignancy. However, few studies have evaluated the roles of genetic variants encoding steroid hormone receptor genes and their related regulators (SHR-related genes) in CM-specific surviva ... Full text Open Access Link to item Cite

Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck.

Journal Article Mol Carcinog · June 2018 Squamous cell carcinoma of head and neck (SCCHN) is one of the most common malignancies worldwide, and nucleotide excision repair (NER) is involved in SCCHN susceptibility. In this analysis of 349 newly diagnosed SCCHN patients and 295 cancer-free controls ... Full text Open Access Link to item Cite

DNA repair capacity correlates with standardized uptake values from 18F-fluorodeoxyglucose positron emission tomography/CT in patients with advanced non-small-cell lung cancer.

Journal Article Chronic diseases and translational medicine · June 2018 ObjectiveThe DNA repair capacity (DRC) of tumor cells is an important contributor to resistance to radiation and platinum-based drugs. Because DRC may be affected by tumor cell metabolism, we measured DRC in lymphocytes from patients with non-smal ... Full text Open Access Cite

Potentially Functional Variants of ATG16L2 Predict Radiation Pneumonitis and Outcomes in Patients with Non-Small Cell Lung Cancer after Definitive Radiotherapy.

Journal Article J Thorac Oncol · May 2018 INTRODUCTION: Autophagy not only plays an important role in the progression of cancer but is also involved in tissue inflammatory response. However, few published studies have investigated associations between functional genetic variants of autophagy-relat ... Full text Open Access Link to item Cite

TGFβ1 Genetic Variants Predict Clinical Outcomes of HPV-Positive Oropharyngeal Cancer Patients after Definitive Radiotherapy.

Journal Article Clin Cancer Res · May 1, 2018 Purpose: TGFβ1 plays a critical role in inflammation and immune responses and treatment response and survival. TGFβ1 variants may affect its expression level or functional efficiency, thus modifying tumor status and survival in human papillomavirus (HPV)-p ... Full text Open Access Link to item Cite

Genetic variants in the platelet-derived growth factor subunit B gene associated with pancreatic cancer risk.

Journal Article Int J Cancer · April 1, 2018 The platelet-derived growth factor (PDGF) signaling pathway plays important roles in development and progression of human cancers. In our study, we aimed to identify genetic variants of the PDGF pathway genes associated with pancreatic cancer (PC) risk in ... Full text Open Access Link to item Cite

An ERCC4 regulatory variant predicts grade-3 or -4 toxicities in patients with advanced non-small cell lung cancer treated by platinum-based therapy.

Journal Article Int J Cancer · March 15, 2018 Platinum-based chemotherapy (PBC) in combination with the 3rd generation drugs is the first-line treatment for patients with advanced non-small cell lung cancer (NSCLC); however, the efficacy is severely hampered by grade 3-4 toxicities. Nucleotide excisio ... Full text Open Access Link to item Cite

Mouse double minute 4 variants modify susceptibility to risk of recurrence in patients with squamous cell carcinoma of the oropharynx.

Journal Article Mol Carcinog · March 2018 Given the crucial role of Mouse double minute 4 (MDM4) oncoprotein in p53 pathway, single nucleotide polymorphisms (SNPs) could serve as such biomarkers for prediction of SCCOP recurrence. Thus, we investigated associations between three tagging putatively ... Full text Open Access Link to item Cite

Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer.

Journal Article Mol Carcinog · February 2018 The P38MAPK pathway participates in regulating cell cycle, inflammation, development, cell death, cell differentiation, and tumorigenesis. Genetic variants of some genes in the P38MAPK pathway are reportedly associated with lung cancer risk. To substantiat ... Full text Open Access Link to item Cite

Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival.

Journal Article Mol Carcinog · January 2018 Metzincins are key molecules in the degradation of the extracellular matrix and play an important role in cellular processes such as cell migration, adhesion, and cell fusion of malignant tumors, including cutaneous melanoma (CM). We hypothesized that gene ... Full text Open Access Link to item Cite

Survival Benefit of Germline BRCA Mutation is Associated with Residual Disease in Ovarian Cancer.

Journal Article Cell Physiol Biochem · 2018 BACKGROUND/AIMS: Prognostic value of germline BRCA1 or BRCA2 (gBRCA1/2) mutations in epithelial ovarian cancer (EOC) remains controversial, especially in the estimation of long-term survival. We previously reported the largest study of gBRCA1/2 mutation pr ... Full text Open Access Link to item Cite

Functional variants in the low-density lipoprotein receptor gene are associated with clear cell renal cell carcinoma susceptibility.

Journal Article Carcinogenesis · December 7, 2017 Recent studies indicate that abnormal levels of low-density lipoprotein (LDL), which is an important component of dyslipidaemia, are associated with alterations to cancer risk, including that of renal cell carcinoma (RCC). Single nucleotide polymorphisms a ... Full text Link to item Cite

Functional genetic variants of XRCC4 and ERCC1 predict survival of gastric cancer patients treated with chemotherapy by regulating the gene expression.

Journal Article Mol Carcinog · December 2017 DNA repair protects genomic integrity and may modulate chemotherapy efficacy. Few large-scale studies have evaluated predictive roles of genetic variants of DNA repair genes in survival of Chinese gastric cancer (GCa) patients treated with chemotherapy. He ... Full text Link to item Cite

Diagnostic accuracy of serum antibodies to human papillomavirus type 16 early antigens in the detection of human papillomavirus-related oropharyngeal cancer.

Journal Article Cancer · December 2017 BackgroundBecause of the current epidemic of human papillomavirus (HPV)-related oropharyngeal cancer (OPC), a screening strategy is urgently needed. The presence of serum antibodies to HPV-16 early (E) antigens is associated with an increased risk ... Full text Cite

Genetic variants in microRNA-binding sites of DNA repair genes as predictors of recurrence in patients with squamous cell carcinoma of the oropharynx.

Journal Article Int J Cancer · October 1, 2017 The incidence of squamous cell carcinoma of the oropharynx (SCCOP) continues to rise because of increasing rates of human papillomavirus (HPV) infection. Inherited polymorphisms in DNA repair pathways may influence the risk of SCCOP development and the pro ... Full text Link to item Cite

Genetic variants of PDGF signaling pathway genes predict cutaneous melanoma survival.

Journal Article Oncotarget · September 26, 2017 To investigate whether genetic variants of platelet-derived growth factor (PDGF) signaling pathway genes are associated with survival of cutaneous melanoma (CM) patients, we assessed associations of single-nucleotide polymorphisms in PDGF pathway with mela ... Full text Open Access Link to item Cite

Genetic variants in ERCC1 and XPC predict survival outcome of non-small cell lung cancer patients treated with platinum-based therapy.

Journal Article Sci Rep · September 6, 2017 Nucleotide excision repair (NER) plays a vital role in platinum-induced DNA damage during chemotherapy. We hypothesize that regulatory single nucleotide polymorphisms (rSNPs) of the core NER genes modulate clinical outcome of patients with advanced non-sma ... Full text Open Access Link to item Cite

Associations between RNA splicing regulatory variants of stemness-related genes and racial disparities in susceptibility to prostate cancer.

Journal Article Int J Cancer · August 15, 2017 Evidence suggests that cells with a stemness phenotype play a pivotal role in oncogenesis, and prostate cells exhibiting this phenotype have been identified. We used two genome-wide association study (GWAS) datasets of African descendants, from the Multiet ... Full text Link to item Cite

Genetic variants in the genes encoding rho GTPases and related regulators predict cutaneous melanoma-specific survival.

Journal Article Int J Cancer · August 15, 2017 Rho GTPases control cell division, motility, adhesion, vesicular trafficking and phagocytosis, which may affect progression and/or prognosis of cancers. Here, we investigated associations between genetic variants of Rho GTPases-related genes and cutaneous ... Full text Link to item Cite

Genetic Variants in WNT2B and BTRC Predict Melanoma Survival.

Journal Article J Invest Dermatol · August 2017 Cutaneous melanoma (CM) is the most lethal skin cancer. The Wnt pathway has an impact on development, invasion, and metastasis of CM, thus likely affecting CM prognosis. Using data from a published genome-wide association study from The University of Texas ... Full text Link to item Cite

Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease.

Journal Article Mutat Res · August 2017 The rise of advanced technologies for characterizing human populations at the molecular level, from sequence to function, is shifting disease prevention paradigms toward personalized strategies. Because minimization of adverse outcomes is a key driver for ... Full text Link to item Cite

Pathway-analysis of published genome-wide association studies of lung cancer: A potential role for the CYP4F3 locus.

Journal Article Mol Carcinog · June 2017 The fatty acids (FAs) metabolism is suggested to play a pivotal role in the development of lung cancer, and we explored that by conducting a pathway-based analysis. We performed a meta-analysis of published datasets of six genome wide association studies ( ... Full text Link to item Cite

BRCA1 and BRCA2 mutations in ovarian cancer patients from China: ethnic-related mutations in BRCA1 associated with an increased risk of ovarian cancer.

Journal Article Int J Cancer · May 1, 2017 BRCA1/2 are cancer predisposition genes involved in hereditary breast and ovarian cancer (HBOC). Mutation carriers display an increased sensitivity to inhibitors of poly(ADP-ribose) polymerase (PARP). Despite a number of small-size hospital-based studies b ... Full text Link to item Cite

Reduced mRNA expression of nucleotide excision repair genes in lymphocytes and risk of squamous cell carcinoma of the head and neck.

Journal Article Carcinogenesis · May 1, 2017 Nucleotide excision repair (NER) plays a critical role in the development of smoking-related cancers. We hypothesize that mRNA expression levels of NER genes are associated with risk of the squamous cell carcinoma of head and neck (SCCHN). To test this hyp ... Full text Link to item Cite

Functional variants in DCAF4 associated with lung cancer risk in European populations.

Journal Article Carcinogenesis · May 1, 2017 Cullin-RING ubiquitin ligases (CRLs) responsible for substrate specificity of ubiquitination play a key role in cell-cycle control and DNA damage response. In this study, we assessed associations between 16 599 SNPs in 115 CRL genes and lung cancer risk by ... Full text Link to item Cite

Polymorphisms in nucleotide excision repair genes and risk of primary prostate cancer in Chinese Han populations.

Journal Article Oncotarget · April 11, 2017 Genetic variants of nucleotide excision repair (NER) genes have been extensively investigated for their roles in the development of prostate cancer (PCa); however, the published results have been inconsistent. In a hospital-based case-control study of 1,00 ... Full text Open Access Link to item Cite

Genetic variants of PTPN2 are associated with lung cancer risk: a re-analysis of eight GWASs in the TRICL-ILCCO consortium.

Journal Article Sci Rep · April 11, 2017 The T-cell protein tyrosine phosphatase (TCPTP) pathway consists of signaling events mediated by TCPTP. Mutations and genetic variants of some genes in the TCPTP pathway are associated with lung cancer risk and survival. In the present study, we first inve ... Full text Open Access Link to item Cite

E2F transcription factor 2 variants as predictive biomarkers for recurrence risk in patients with squamous cell carcinoma of the oropharynx.

Journal Article Mol Carcinog · April 2017 Because E2F transcription factor 2 (E2F2) promoter polymorphisms have been implicated in carcinogenesis and prognosis, we investigated associations between genetic variants in five E2F2 promoter polymorphisms and recurrence risk of squamous cell carcinoma ... Full text Link to item Cite

Association between miRNA-binding site polymorphisms in double-strand break repair genes and risk of recurrence in patients with squamous cell carcinomas of the non-oropharynx.

Journal Article Carcinogenesis · April 1, 2017 Genetic polymorphisms at miRNA-binding sites may affect miRNA-mediated gene regulation. Thus, miRNA-binding site polymorphisms in double-strand break (DSB) repair genes may affect DNA repair capacity, which in turn could affect cancer prognosis. To determi ... Full text Link to item Cite

MDM4 genetic variants and risk of gastric cancer in an Eastern Chinese population.

Journal Article Oncotarget · March 21, 2017 MDM4 is a p53-interacting protein and plays an important role in carcinogenesis. In this study of 1,077 gastric cancer (GCa) cases and 1,173 matched cancer-free controls, we investigated associations between three tagging single nucleotide polymorphisms (S ... Full text Open Access Link to item Cite

Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs.

Journal Article Sci Rep · March 17, 2017 mRNA splicing is an important mechanism to regulate mRNA expression. Abnormal regulation of this process may lead to lung cancer. Here, we investigated the associations of 11,966 single-nucleotide polymorphisms (SNPs) in 206 mRNA splicing-related genes wit ... Full text Open Access Link to item Cite

Genetic variants in the integrin signaling pathway genes predict cutaneous melanoma survival.

Journal Article Int J Cancer · March 15, 2017 To identify genetic variants involved in prognosis of cutaneous melanoma (CM), we investigated associations of single nucleotide polymorphisms (SNPs) of genes in the integrin signaling pathway with CM survival by re-analyzing a published genome-wide associ ... Full text Link to item Cite

Is there a dose-dependent effect of genetic susceptibility loci for gastric cancer on prognosis of the patients?

Journal Article Oncotarget · March 14, 2017 Literature suggests that genetic variants associated with increased susceptibility to gastric cancer (GCa) are mostly located in genes involved in carcinogenesis and possibly tumor progression. Therefore, we hypothesize that high genetic susceptibility is ... Full text Open Access Link to item Cite

Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma.

Journal Article Oncotarget · March 14, 2017 Genome-wide association studies have identified 21 susceptibility loci associated with melanoma. These loci implicate genes affecting pigmentation, nevus count, telomere maintenance, and DNA repair in melanoma risk. Here, we report the results of a two-sta ... Full text Open Access Link to item Cite

A functional variant at the miRNA binding site in E2F1 gene is associated with risk and tumor HPV16 status of oropharynx squamous cell carcinoma.

Journal Article Mol Carcinog · March 2017 Human papillomavirus (HPV) activates E2F1-driven transcription via the E7-RB1-E2F pathway. Genetic polymorphisms in the 3' untranslated region (UTR) targeted by miRNAs can affect the regulation of target genes and individual cancer risk. Thus, we hypothesi ... Full text Link to item Cite

Genetic variants of JNK and p38α pathways and risk of non-small cell lung cancer in an Eastern Chinese population.

Journal Article Int J Cancer · February 15, 2017 The JNK and p38α pathways play an important role in carcinogenesis. Therefore, we hypothesize that single nucleotide polymorphisms (SNPs) of genes involved in these pathways are associated with risk of lung cancer. We first selected and genotyped 11 indepe ... Full text Link to item Cite

Apoptotic capacity and risk of squamous cell carcinoma of the head and neck.

Journal Article Eur J Cancer · February 2017 BACKGROUND: Tobacco smoke and alcohol drinking are the major risk factors for squamous cell carcinoma of the head and neck (SCCHN). Smoking and drinking cause DNA damage leading to apoptosis, and insufficient apoptotic capacity may favour development of ca ... Full text Link to item Cite

Modifying effect of mouse double minute-2 promoter variants on risk of recurrence for patients with squamous cell carcinoma of oropharynx.

Journal Article Sci Rep · January 3, 2017 Functional mouse double minute-2 (MDM2) promoter variants may alter MDM2 expression and thus affect radiotherapy response and prognosis of squamous cell carcinoma of oropharynx (SCCOP). Thus we assessed association of 2 functional MDM2 promoter variants wi ... Full text Open Access Link to item Cite

Genetic variants in the PIWI-piRNA pathway gene DCP1A predict melanoma disease-specific survival.

Journal Article Int J Cancer · December 15, 2016 The Piwi-piRNA pathway is important for germ cell maintenance, genome integrity, DNA methylation and retrotransposon control and thus may be involved in cancer development. In this study, we comprehensively analyzed prognostic roles of 3,116 common SNPs in ... Full text Link to item Cite

Associations of genotypes and haplotypes of IL-17 with risk of gastric cancer in an eastern Chinese population.

Journal Article Oncotarget · December 13, 2016 Interleukin-17 plays a crucial role in inflammation-related carcinogenesis. We hypothesize that genetic variants in IL-17 are associated with gastric cancer (GCa) risk, and we genotyped five potentially functional single nucleotide polymorphisms (SNPs) (rs ... Full text Open Access Link to item Cite

The P38α rs3804451 Variant Predicts Chemotherapy Response and Survival of Patients with Non-Small Cell Lung Cancer Treated with Platinum-Based Chemotherapy.

Journal Article Transl Oncol · December 2016 The JNK and P38α pathways play an important role in the sensitivity and outcomes of chemotherapy. We hypothesize that functional single nucleotide polymorphisms (SNPs) of genes of these pathways modulate outcomes of patients with advanced non-small cell lu ... Full text Open Access Link to item Cite

Smokeless Tobacco Use and the Risk of Head and Neck Cancer: Pooled Analysis of US Studies in the INHANCE Consortium.

Journal Article Am J Epidemiol · November 15, 2016 Previous studies on smokeless tobacco use and head and neck cancer (HNC) have found inconsistent and often imprecise estimates, with limited control for cigarette smoking. Using pooled data from 11 US case-control studies (1981-2006) of oral, pharyngeal, a ... Full text Link to item Cite

A comprehensive genome-wide analysis of melanoma Breslow thickness identifies interaction between CDC42 and SCIN genetic variants.

Journal Article Int J Cancer · November 1, 2016 Breslow thickness (BT) is a major prognostic factor of cutaneous melanoma (CM), the most fatal skin cancer. The genetic component of BT has only been explored by candidate gene studies with inconsistent results. Our objective was to uncover the genetic fac ... Full text Link to item Cite

Effect of human papillomavirus seropositivity and E2F2 promoter variants on risk of squamous cell carcinomas of oropharynx and oral cavity.

Journal Article Carcinogenesis · November 1, 2016 Given roles of HPV and genetic factors in cancer risk, we evaluated associations of HPV16 seropositivity and five E2F2 promoter variants with squamous cell carcinoma of oropharynx (SCCOP) and squamous cell carcinoma of oral cavity (SCCOC) risk in a case-co ... Full text Link to item Cite

A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer.

Journal Article Sci Rep · October 7, 2016 Lung cancer etiology is multifactorial, and growing evidence has indicated that long non-coding RNAs (lncRNAs) are important players in lung carcinogenesis. We performed a large-scale meta-analysis of 690,564 SNPs in 15,531 autosomal lncRNAs by using datas ... Full text Open Access Link to item Cite

Genetic variants of genes in the Notch signaling pathway predict overall survival of non-small cell lung cancer patients in the PLCO study.

Journal Article Oncotarget · September 20, 2016 The Notch signaling pathway has been shown to have biological significance and therapeutic application in non-small cell lung cancer (NSCLC). We hypothesize that genetic variants of genes in the Notch signaling pathway are associated with overall survival ... Full text Open Access Link to item Cite

Genetic variant in DNA repair gene GTF2H4 is associated with lung cancer risk: a large-scale analysis of six published GWAS datasets in the TRICL consortium.

Journal Article Carcinogenesis · September 2016 DNA repair pathways maintain genomic integrity and stability, and dysfunction of DNA repair leads to cancer. We hypothesize that functional genetic variants in DNA repair genes are associated with risk of lung cancer. We performed a large-scale meta-analys ... Full text Link to item Cite

Associations between smoking behavior-related alleles and the risk of melanoma.

Journal Article Oncotarget · July 26, 2016 Several studies have reported that cigarette smoking is inversely associated with the risk of melanoma. This study further tested whether incorporating genetic factors will provide another level of evaluation of mechanisms underlying the association betwee ... Full text Open Access Link to item Cite

Single Nucleotide Polymorphisms in CBLB, a Regulator of T-Cell Response, Predict Radiation Pneumonitis and Outcomes After Definitive Radiotherapy for Non-Small-Cell Lung Cancer.

Journal Article Clin Lung Cancer · July 2016 BACKGROUND: The immune system has important roles in tumor development and outcomes after cancer treatment. We evaluated whether single-nucleotide polymorphisms (SNPs) in the gene encoding casitas B-lineage lymphoma b protein (Cbl-b), an E3 ubiquitin ligas ... Full text Link to item Cite

A functional variant at miRNA-122 binding site in IL-1a 3' UTR predicts risk of recurrence in patients with oropharyngeal cancer.

Journal Article Oncotarget · June 7, 2016 IL-1a, an important regulator of immune and inflammation responses, has been implicated in cancer development and prognosis. An insertion (Ins)/deletion (Del) polymorphism (IL-1a rs3783553) in the 3' UTR of IL-1a may disrupt a binding site for miRNA-122 an ... Full text Open Access Link to item Cite

Significance of microRNA-related variants in susceptibility to recurrence of oropharyngeal cancer patients after definitive radiotherapy.

Journal Article Oncotarget · June 7, 2016 Common single nucleotide polymorphisms (SNPs) in miRNAs may affect miRNA functions and their target expression and thus may affect biological activities and cancer etiology as well as prognosis. Thus, we determined whether the 9 SNPs in microRNAs modify th ... Full text Open Access Link to item Cite

A variant at a potentially functional microRNA-binding site in BRIP1 was associated with risk of squamous cell carcinoma of the head and neck.

Journal Article Tumour Biol · June 2016 DNA double-strand breaks (DSBs) are one of the most serious forms of DNA damage to the cell, causing genomic instability and ultimately carcinogenesis. In this study, we hypothesized that single nucleotide polymorphisms (SNPs) at the micro RNA (miRNA)-bind ... Full text Link to item Cite

Genetic variants in ABCG1 are associated with survival of nonsmall-cell lung cancer patients.

Journal Article Int J Cancer · June 1, 2016 Cell membrane transporters and metabolic enzymes play a crucial role in the transportation of a wide variety of substrates that maintain homeostasis in biological processes. We explored associations between genetic variants in these genes and survival of n ... Full text Link to item Cite

Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis.

Journal Article Int J Epidemiol · June 2016 BACKGROUND: Cigarette smoking is a major risk factor for head and neck cancer (HNC). To our knowledge, low cigarette smoking (<10 cigarettes per day) has not been extensively investigated in fine categories or among never alcohol drinkers. METHODS: We cond ... Full text Link to item Cite

Genetic variants of DNA repair genes predict the survival of patients with esophageal squamous cell cancer receiving platinum-based adjuvant chemotherapy.

Journal Article J Transl Med · May 31, 2016 BACKGROUND: Adjuvant chemotherapy in patients with resected esophageal squamous cell cancer (ESCC) remains controversial for its uncertain role in improving overall survival (OS). Nucleotide excision repair (NER) removes DNA-adducts in tumor cells induced ... Full text Open Access Link to item Cite

Association of Vitamin D Levels With Outcome in Patients With Melanoma After Adjustment For C-Reactive Protein.

Journal Article J Clin Oncol · May 20, 2016 PURPOSE: To evaluate for an association between 25-hydroxyvitamin D levels (vitamin D) and outcome measures in patients with melanoma after evaluation is controlled for systemic inflammatory response (SIR) on the basis of simultaneous C-reactive protein (C ... Full text Link to item Cite

Associations of potentially functional variants in IL-6, JAKs and STAT3 with gastric cancer risk in an eastern Chinese population.

Journal Article Oncotarget · May 10, 2016 The interleukin-6 (IL-6)/JAK/STAT3 signaling pathway plays a central role in inflammation-mediated cancers, including gastric cancer (GCa). We evaluated associations between 10 potentially functional single nucleotide polymorphisms (SNPs) of four essential ... Full text Open Access Link to item Cite

Genetic variants of GADD45A, GADD45B and MAPK14 predict platinum-based chemotherapy-induced toxicities in Chinese patients with non-small cell lung cancer.

Journal Article Oncotarget · May 3, 2016 The JNK and P38α pathways play a crucial role in tissue homeostasis, apoptosis and autophagy under genotoxic stresses, but it is unclear whether single nucleotide polymorphisms (SNPs) of genes in these pathways play a role in platinum-based chemotherapy-in ... Full text Open Access Link to item Cite

Pre-miRNA variants as predictors of clinical outcome in patients with squamous cell carcinomas of the nonoropharynx.

Journal Article Oncotarget · May 3, 2016 Functional polymorphisms of miRNAs may affect the function and target expression of miRNAs, which can, in turn, affect the biological activity, etiology, and prognosis of cancer. We hypothesized that four common polymorphisms in pre-miRNAs (hsa-mir-146a rs ... Full text Open Access Link to item Cite

Squamous cell carcinoma of the oral cavity often overexpresses p16 but is rarely driven by human papillomavirus.

Journal Article Oral Oncol · May 2016 OBJECTIVE: Human papillomavirus (HPV) is a causal and prognostic factor for oropharyngeal cancer, but its role in squamous cell carcinoma of the oral cavity (SCCOC) is unclear. We sought to clarify HPV's role in SCCOC. MATERIALS AND METHODS: Patients with ... Full text Link to item Cite

4-nitroquinoline-1-oxide-induced mutagen sensitivity and risk of cutaneous melanoma: a case-control analysis.

Journal Article Melanoma Res · April 2016 Mutagen sensitivity assay, which measures the enhanced cellular response to DNA damage induced in vitro by mutagens/carcinogens, has been used in the study of cancer susceptibility. 4-Nitroquinoline-1-oxide (4-NQO), an ultraviolet (UV) radiation-mimetic ch ... Full text Link to item Cite

Genetic variants in miR-196a2 and miR-499 are associated with susceptibility to esophageal squamous cell carcinoma in Chinese Han population.

Journal Article Tumour Biol · April 2016 Esophageal squamous cell carcinoma (ESCC) is the dominant type of esophageal cancer in the East Asian population. MicroRNAs (miRNAs) have been studied to play important roles in tumorigenesis. Single nucleotide polymorphisms (SNPs) in miRNA lead to the abe ... Full text Link to item Cite

Polymorphisms in the AKT1 and AKT2 genes and oesophageal squamous cell carcinoma risk in an Eastern Chinese population.

Journal Article J Cell Mol Med · April 2016 Ethnic Han Chinese are at high risk of developing oesophageal squamous cell carcinoma (ESCC). Aberrant activation of the AKT signalling pathway is involved in many cancers, including ESCC. Some single nucleotide polymorphisms (SNPs) in genes involved in th ... Full text Open Access Link to item Cite

Reduced DNA double-strand break repair capacity and risk of squamous cell carcinoma of the head and neck--A case-control study.

Journal Article DNA Repair (Amst) · April 2016 Tobacco smoke and alcohol use play important roles in the etiology of squamous cell carcinoma of the head and neck (SCCHN). Smoking causes DNA damage, including double-strand DNA breaks (DSBs), that leads to carcinogenesis. To test the hypothesis that subo ... Full text Link to item Cite

Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population.

Journal Article Oncotarget · March 29, 2016 Published data on the association between the MUC1 rs4072037A > G polymorphism and gastric cancer (GCa) risk were inconclusive. To derive a more precise estimation of the association, we conducted a large GCa study of 1,124 cases and 1,192 controls to conf ... Full text Open Access Link to item Cite

Genetic variants in the vitamin D pathway genes VDBP and RXRA modulate cutaneous melanoma disease-specific survival.

Journal Article Pigment Cell Melanoma Res · March 2016 Single nucleotide polymorphisms (SNPs) in the vitamin D pathway genes have been implicated in cutaneous melanoma (CM) risk, but their role in CM disease-specific survival (DSS) remains obscure. We comprehensively analyzed the prognostic roles of 2669 commo ... Full text Link to item Cite

Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta-analysis of 14,463 cases and 44,188 controls.

Journal Article Carcinogenesis · March 2016 Centrosome abnormalities are often observed in premalignant lesions and in situ tumors and have been associated with aneuploidy and tumor development. We investigated the associations of 9354 single-nucleotide polymorphisms (SNPs) in 106 centrosomal genes ... Full text Link to item Cite

PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population.

Journal Article Oncotarget · February 23, 2016 The prostate stem cell antigen (PSCA) gene, which encodes a prostate-specific antigen (PSA), was identified as a gene involved in cell adhesion and proliferation. The associations between the PSCA rs2294008 and rs2976392 single nucleotide polymorphisms (SN ... Full text Open Access Link to item Cite

Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck.

Journal Article BMC Cancer · February 8, 2016 BACKGROUND: FAS/FASL promoter variants are considered in altering transcriptional activity of those genes and consequently alter regulation of cell death. However, no studies have investigated whether tumor sites contribute to the association between FAS/F ... Full text Open Access Link to item Cite

A Functional Polymorphism (rs2494752) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population.

Journal Article Sci Rep · January 28, 2016 AKT is an important signal transduction protein that plays a crucial role in cancer development. Therefore, we evaluated associations between single nucleotide polymorphisms (SNPs) in the AKT promoter region and gastric cancer (GCa) risk in a case-control ... Full text Open Access Link to item Cite

Component-wise gradient boosting and false discovery control in survival analysis with high-dimensional covariates.

Journal Article Bioinformatics · January 1, 2016 MOTIVATION: Technological advances that allow routine identification of high-dimensional risk factors have led to high demand for statistical techniques that enable full utilization of these rich sources of information for genetics studies. Variable select ... Full text Open Access Link to item Cite

Genetic variations in the homologous recombination repair pathway genes modify risk of glioma.

Journal Article J Neurooncol · January 2016 Accumulative epidemiological evidence suggests that single nucleotide polymorphisms (SNPs) in genes involved in homologous recombination (HR) DNA repair pathway play an important role in glioma susceptibility. However, the effects of such SNPs on glioma ri ... Full text Link to item Cite

Genetic variant of PRKAA1 and gastric cancer risk in an eastern Chinese population.

Journal Article Oncotarget · December 15, 2015 Published data on the association between PRKAA1 rs13361707 T > C polymorphism and gastric cancer (GCa) susceptibility were inconclusive. To derive a more precise estimation of the association, we conducted a large-scale GCa study of 1,124 cases and 1,194 ... Full text Open Access Link to item Cite

Genetic variants in the TEP1 gene are associated with prostate cancer risk and recurrence.

Journal Article Prostate Cancer Prostatic Dis · December 2015 BACKGROUND: Telomere-related genes play an important role in carcinogenesis and progression of prostate cancer (PCa). It is not fully understood whether genetic variations in telomere-related genes are associated with development and progression in PCa pat ... Full text Open Access Link to item Cite

Apoptotic variants as predictors of risk of oropharyngeal cancer recurrence after definitive radiotherapy.

Journal Article Int J Cancer · November 15, 2015 Single nucleotide polymorphisms (SNPs) in the promoter region of FAS and FASLG may alter their transcriptional activity. Thus, we determined the associations between four FAS and FASLG promoter variants (FAS1377G>A, rs2234767; 670A>G, rs1800682; FASLG844T> ... Full text Open Access Link to item Cite

Genetic variations in the mTOR gene contribute toward gastric adenocarcinoma susceptibility in an Eastern Chinese population.

Journal Article Pharmacogenet Genomics · November 2015 BACKGROUND AND AIM: Genetic variants in the mammalian target of rapamycin (mTOR) gene have become an interesting topic for the study of genetic susceptibility to cancer, but their associations with the risk of gastric cancer have not been fully investigate ... Full text Link to item Cite

TNF rs1799964 as a Predictive Factor of Acute Toxicities in Chinese Rectal Cancer Patients Treated With Chemoradiotherapy.

Journal Article Medicine (Baltimore) · November 2015 Acute toxicity is the main dose-limiting factor in the chemoradiotherapy of rectal cancer patients and depends on several pro-inflammatory factors, including interleukin-1 (IL-1), IL-6, and tumor necrosis factor-alpha (TNF-α). It is unknown whether genetic ... Full text Open Access Link to item Cite

miR-449b rs10061133 and miR-4293 rs12220909 polymorphisms are associated with decreased esophageal squamous cell carcinoma in a Chinese population.

Journal Article Tumour Biol · November 2015 Esophageal cancer is one of the most aggressive cancers in the world, 70% of which are from China and esophageal squamous cell carcinoma (ESCC) is the major histopathological form (>90%). The single nucleotide polymorphisms (SNPs) in mature sequence of mic ... Full text Link to item Cite

Whole Exome Sequencing Identifies Frequent Somatic Mutations in Cell-Cell Adhesion Genes in Chinese Patients with Lung Squamous Cell Carcinoma.

Journal Article Sci Rep · October 27, 2015 Lung squamous cell carcinoma (SQCC) accounts for about 30% of all lung cancer cases. Understanding of mutational landscape for this subtype of lung cancer in Chinese patients is currently limited. We performed whole exome sequencing in samples from 100 pat ... Full text Open Access Link to item Cite

Integrated pathway and epistasis analysis reveals interactive effect of genetic variants at TERF1 and AFAP1L2 loci on melanoma risk.

Journal Article Int J Cancer · October 15, 2015 Genome-wide association studies (GWASs) have characterized 13 loci associated with melanoma, which only account for a small part of melanoma risk. To identify new genes with too small an effect to be detected individually but which collectively influence m ... Full text Open Access Link to item Cite

Circulating human papillomavirus DNA as a marker for disease extent and recurrence among patients with oropharyngeal cancer.

Journal Article Cancer · October 1, 2015 BACKGROUND: Circulating Epstein-Barr virus DNA is a predictor of disease recurrence in patients with nasopharyngeal carcinoma. Circulating human papillomavirus (HPV) DNA has been detected in the sera of some patients with HPV-positive squamous cell carcino ... Full text Link to item Cite

Plasma miRNAs as early biomarkers for detecting hepatocellular carcinoma.

Journal Article Int J Cancer · October 1, 2015 The early detection of hepatocellular carcinoma (HCC) presents a challenge because of the lack of specific biomarkers. Serum/plasma microRNAs (miRNAs) can discriminate HCC patients from controls. We aimed to identify and evaluate HCC-associated plasma miRN ... Full text Open Access Link to item Cite

Genetic polymorphisms in the microRNA binding-sites of the thymidylate synthase gene predict risk and survival in gastric cancer.

Journal Article Mol Carcinog · September 2015 Thymidylate synthase (TYMS) plays a crucial role in folate metabolism as well as DNA synthesis and repair. We hypothesized that functional polymorphisms in the 3' UTR of TYMS are associated with gastric cancer risk and survival. In the present study, we te ... Full text Link to item Cite

Genetic Variants of the MDM2 Gene Are Predictive of Treatment-Related Toxicities and Overall Survival in Patients With Advanced NSCLC.

Journal Article Clin Lung Cancer · September 2015 INTRODUCTION: Platinum agents can cause the formation of DNA adducts and induce apoptosis to eliminate tumor cells. The aim of the present study was to investigate the influence of genetic variants of MDM2 on chemotherapy-related toxicities and clinical ou ... Full text Open Access Link to item Cite

Association of Common Genetic Polymorphisms with Melanoma Patient IL-12p40 Blood Levels, Risk, and Outcomes.

Journal Article J Invest Dermatol · September 2015 Recent investigation has identified association of IL-12p40 blood levels with melanoma recurrence and patient survival. No studies have investigated associations of single-nucleotide polymorphisms (SNPs) with melanoma patient IL-12p40 blood levels or their ... Full text Open Access Link to item Cite

Polymorphisms in the kinesin-like factor 1 B gene and risk of epithelial ovarian cancer in Eastern Chinese women.

Journal Article Tumour Biol · September 2015 The kinesin-like factor 1 B (KIF1B) gene plays an important role in the process of apoptosis and the transformation and progression of malignant cells. Genetic variations in KIF1B may contribute to risk of epithelial ovarian cancer (EOC). In this study of ... Full text Open Access Link to item Cite

Socioeconomic characteristics of patients with oropharyngeal carcinoma according to tumor HPV status, patient smoking status, and sexual behavior.

Journal Article Oral Oncol · September 2015 OBJECTIVES: Patients with oropharyngeal cancer (OPC) have distinct risk factor profiles reflected in the human papillomavirus (HPV) status of their tumor, and these profiles may also be influenced by factors related to socioeconomic status (SES). The goal ... Full text Link to item Cite

Two novel PRKCI polymorphisms and prostate cancer risk in an Eastern Chinese Han population.

Journal Article Mol Carcinog · August 2015 The atypical protein kinase C (aPKCι), encoded by the PRKCI gene, has been recently found to be a unique human oncoprotein, compared with some other diverse PKC isozymes. Genetic variations in PRKCI have also been reported to be associated with prostate ca ... Full text Link to item Cite

Genetic variants in Hippo pathway genes YAP1, TEAD1 and TEAD4 are associated with melanoma-specific survival.

Journal Article Int J Cancer · August 1, 2015 Cutaneous melanoma (CM) is the most lethal form of skin cancers. The Hippo pathway controls cell migration, development and sizes of the organs in diverse species, and deregulation of this pathway may affect CM progression and prognosis. Therefore, we hypo ... Full text Link to item Cite

Functional Variants in Notch Pathway Genes NCOR2, NCSTN, and MAML2 Predict Survival of Patients with Cutaneous Melanoma.

Journal Article Cancer Epidemiol Biomarkers Prev · July 2015 BACKGROUND: The Notch signaling pathway is constitutively activated in human cutaneous melanoma to promote growth and aggressive metastatic potential of primary melanoma cells. Therefore, genetic variants in Notch pathway genes may affect the prognosis of ... Full text Open Access Link to item Cite

A functional variant at miRNA-122 binding site in IL-1α 3' UTR predicts risk and HPV-positive tumours of oropharyngeal cancer.

Journal Article Eur J Cancer · July 2015 BACKGROUND: Genetic polymorphisms in the 3' untranslated regions (3' UTRs) targeted by miRNAs alter the strength of miRNA binding in a manner that affects the behaviour of individual miRNAs. An insertion (Ins)/deletion (Del) polymorphism (rs3783553) in the ... Full text Link to item Cite

HPV16 antibodies as risk factors for oropharyngeal cancer and their association with tumor HPV and smoking status.

Journal Article Oral Oncol · July 2015 BACKGROUND: Antibodies (Abs) to the HPV16 proteome increase risk for HPV-associated OPC (HPVOPC). The goal of this study was to investigate the association of a panel of HPV16 Abs with risk for OPC as well as the association of these Abs with tumor HPV and ... Full text Open Access Link to item Cite

Polymorphisms at the microRNA binding-site of the stem cell marker gene CD133 modify susceptibility to and survival of gastric cancer.

Journal Article Mol Carcinog · June 2015 CD133 is one of the most common stem cell markers, and functional single nucleotide polymorphisms (SNPs) of CD133 may modulate its gene functions and thus cancer risk and patient survival. We hypothesized that potentially functional CD133 SNPs are associat ... Full text Open Access Link to item Cite

Teenage acne and cancer risk in US women: A prospective cohort study.

Journal Article Cancer · May 15, 2015 BACKGROUND: Acne reflects hormone imbalance and is a key component of several systemic diseases. We hypothesized that diagnosis of acne as a teenager might predict subsequent risk of hormone-related cancers. METHODS: We followed 99,128 female nurses in the ... Full text Link to item Cite

C-reactive protein as a marker of melanoma progression.

Journal Article J Clin Oncol · April 20, 2015 PURPOSE: To investigate the association between blood levels of C-reactive protein (CRP) in patients with melanoma and overall survival (OS), melanoma-specific survival (MSS), and disease-free survival. PATIENTS AND METHODS: Two independent sets of plasma ... Full text Link to item Cite

The relationship between blood IL-12p40 level and melanoma progression.

Journal Article Int J Cancer · April 15, 2015 Cytokines such as Interleukin (IL)-12p70 ("IL-12") and IL-23 can influence tumor progression. We tested the hypothesis that blood levels of IL-12p40, the common subunit of both cytokines, are associated with melanoma progression. Blood from 2,048 white mel ... Full text Open Access Link to item Cite

Genetic variant rs16430 6bp > 0bp at the microRNA-binding site in TYMS and risk of sporadic breast cancer risk in non-Hispanic white women aged ≤ 55 years.

Journal Article Mol Carcinog · April 2015 Thymidylate synthase (TYMS) is involved in the folate metabolism and provision of nucleotides needed for DNA synthesis and repair. Thus, functional genetic variants in TYMS may alter cancer risk. In the study, we evaluated associations of three germline va ... Full text Link to item Cite

CASP7 variants modify susceptibility to cervical cancer in Chinese women.

Journal Article Sci Rep · March 18, 2015 Polymorphisms in Caspase-7 (CASP7) may modulate the programmed cell death and thus contribute to cervical cancer risk. In this case-control study of 1,486 cervical cancer cases and 1,301 controls, we investigated associations between four potentially funct ... Full text Open Access Link to item Cite

Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries.

Journal Article Int J Cancer · March 1, 2015 Low socioeconomic status has been reported to be associated with head and neck cancer risk. However, previous studies have been too small to examine the associations by cancer subsite, age, sex, global region and calendar time and to explain the associatio ... Full text Link to item Cite

Associations of PI3KR1 and mTOR polymorphisms with esophageal squamous cell carcinoma risk and gene-environment interactions in Eastern Chinese populations.

Journal Article Sci Rep · February 5, 2015 Single nucleotide polymorphisms (SNPs) in the PI3K/PTEN/AKT/mTOR signaling pathway may contribute to carcinogenesis. We genotyped five potentially functional PIK3R1 and mTOR SNPs in 1116 esophageal squamous cell cancer (ESCC) patients and 1117 cancer-free ... Full text Open Access Link to item Cite

Genetic variants in fanconi anemia pathway genes BRCA2 and FANCA predict melanoma survival.

Journal Article J Invest Dermatol · February 2015 Cutaneous melanoma (CM) is the most lethal skin cancer. The Fanconi anemia (FA) pathway involved in DNA crosslink repair may affect CM susceptibility and prognosis. Using data derived from published genome-wide association study, we comprehensively analyze ... Full text Open Access Link to item Cite

Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium.

Journal Article Int J Epidemiol · February 2015 BACKGROUND: Increasing incidence of head and neck cancer (HNC) in young adults has been reported. We aimed to compare the role of major risk factors and family history of cancer in HNC in young adults and older patients. METHODS: We pooled data from 25 cas ... Full text Link to item Cite

Genetic polymorphisms of PAI-1 and PAR-1 are associated with acute normal tissue toxicity in Chinese rectal cancer patients treated with pelvic radiotherapy.

Journal Article Onco Targets Ther · 2015 Plasminogen activator inhibitor type 1 (PAI-1) and protease-activated receptor-1 (PAR-1) are crucial mediators of the intestinal microenvironment and are involved in radiation-induced acute and chronic injury. To evaluate whether genetic polymorphisms of P ... Full text Open Access Link to item Cite

A recessive variant of XRCC4 predisposes to non- BRCA1/2 breast cancer in chinese women and impairs the DNA damage response via dysregulated nuclear localization.

Journal Article Oncotarget · December 15, 2014 XRCC4 plays a crucial role in the non-homologous end joining pathway that maintains genome stability. In this two-stage case-control study with 1,764 non-BRCA1/2 breast cancer patients and 1,623 cancer-free controls, we investigated the contribution of gen ... Full text Open Access Link to item Cite

Serum inflammatory miRNAs predict radiation esophagitis in patients receiving definitive radiochemotherapy for non-small cell lung cancer.

Journal Article Radiother Oncol · December 2014 BACKGROUND AND PURPOSE: MicroRNAs (miRNAs) are small, highly conserved non-coding RNAs that regulate many biological processes. We sought to investigate whether three serum miRNAs related to immunity or inflammation were associated with esophagitis induced ... Full text Link to item Cite

Polymorphisms in MicroRNAs are associated with survival in non-small cell lung cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · November 2014 BACKGROUND: MicroRNAs (miRNA) play important roles in the regulation of eukaryotic gene expression and are involved in human carcinogenesis. Single-nucleotide polymorphisms (SNP) in miRNA sequence may alter miRNA functions in gene regulation, which, in tur ... Full text Link to item Cite

Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population.

Journal Article Nat Genet · October 2014 To identify genetic markers for laryngeal squamous cell carcinoma (LSCC), we conducted a genome-wide association study (GWAS) on 993 individuals with LSCC (cases) and 1,995 cancer-free controls from Chinese populations. The most promising variants (associa ... Full text Link to item Cite

TNF-α promoter polymorphisms and risk of recurrence in patients with squamous cell carcinomas of the nonoropharynx.

Journal Article Int J Cancer · October 1, 2014 Functional polymorphisms of tumor necrosis factor-alpha (TNF-α) may play a critical role in the regulation of immune and inflammatory responses and could affect transcriptional levels of the TNF-α gene and thus contribute to carcinogenesis and outcomes of ... Full text Link to item Cite

Potentially functional polymorphisms in the ERCC2 gene and risk of esophageal squamous cell carcinoma in Chinese populations.

Journal Article Sci Rep · September 11, 2014 ERCC2 is indispensable for nucleotide excision repair pathway, and its functional polymorphisms may be associated with cancer risk. In a large case-control study of 1126 esophageal squamous cell carcinomas (ESCC) patients and 1131 controls, we genotyped tw ... Full text Open Access Link to item Cite

Potentially functional variants in the core nucleotide excision repair genes predict survival in Japanese gastric cancer patients.

Journal Article Carcinogenesis · September 2014 Functional genetic variants of DNA repair genes may alter the host DNA repair capacity, and thus influence efficiency of therapies. We genotyped eight potentially functional single nucleotide polymorphisms (SNPs) in genes (i.e. ERCC1, XPA, XPC, XPD and XPG ... Full text Link to item Cite

Identification of a melanoma susceptibility locus and somatic mutation in TET2.

Journal Article Carcinogenesis · September 2014 Although genetic studies have reported a number of loci associated with melanoma risk, the complex genetic architecture of the disease is not yet fully understood. We sought to identify common genetic variants associated with melanoma risk in a genome-wide ... Full text Link to item Cite

Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women.

Journal Article Nat Commun · August 19, 2014 Ovarian cancer is the leading cause of death from gynaecological malignancies worldwide. Here we perform a three-stage genome-wide association study (GWAS) in Han Chinese women to identify risk genetic variants for epithelial ovarian cancer (EOC). We scan ... Full text Link to item Cite

Genetic variants of the LIN28B gene predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy.

Journal Article Eur J Cancer · July 2014 BACKGROUND: LIN28 is an RNA-binding protein that not only plays key roles in multiple cellular developmental processes and tumourigenesis, but also is involved in tissue inflammatory response. However, no published study has investigated associations betwe ... Full text Link to item Cite

Natural and orthogonal model for estimating gene-gene interactions applied to cutaneous melanoma.

Journal Article Hum Genet · May 2014 Epistasis, or gene-gene interaction, results from joint effects of genes on a trait; thus, the same alleles of one gene may display different genetic effects in different genetic backgrounds. In this study, we generalized the coding technique of a natural ... Full text Link to item Cite

Genetic variants in TNF-α promoter are predictors of recurrence in patients with squamous cell carcinoma of oropharynx after definitive radiotherapy.

Journal Article Int J Cancer · April 15, 2014 The promoter variants of TNF-α, a major regulator of immune and inflammation responses, have been implicated in cancer development and prognosis. Thus, we investigated associations between four TNF-α promoter variants and risk of recurrence of squamous cel ... Full text Link to item Cite

Functional single nucleotide polymorphisms of the RASSF3 gene and susceptibility to squamous cell carcinoma of the head and neck.

Journal Article Eur J Cancer · February 2014 BACKGROUND: RASSF3 suppresses tumour formation through uncertain mechanisms, but it is an important gene of p53-dependent apoptosis. RASSF3 depletion impairs DNA repair after DNA damage, leading to polyploidy. The authors hypothesised that potential functi ... Full text Link to item Cite

Identification of prohibitin and prohibiton as novel factors binding to the p53 induced gene 3 (PIG3) promoter (TGYCC)(15) motif.

Journal Article Biochem Biophys Res Commun · January 24, 2014 The promoter of p53 induced gene 3 (PIG3) contains a variable number of tandem repeats (VNTRs) of pentanucleotides (TGYCC)n that is known as a p53 binding site. In this study, we investigated whether other potential molecules could bind to this PIG3 promot ... Full text Link to item Cite

Influence of smoking history on imaging characteristics among patients with human papillomavirus-positive oropharyngeal cancer: a blinded matched-pair analysis.

Journal Article J Comput Assist Tomogr · 2014 BACKGROUND AND PURPOSE: Human papillomavirus (HPV)-positive oropharyngeal cancers represent a distinct clinical entity with more favorable prognosis than do HPV-negative oropharyngeal cancers. However, among patients with HPV-positive oropharyngeal carcino ... Full text Link to item Cite

Genetic variations of the ADIPOQgene and risk of prostate cancer in Chinese Han men.

Journal Article Asian J Androl · 2014 Adiponectin secreted by adipose tissue has been implicated in prostate carcinogenesis. Genetic variations in ADIPOQ are thought to influence the activity of adiponectin, thus relating to cancer occurrence. In this hospital-based case-control study of 917 p ... Full text Open Access Link to item Cite

Association of marijuana smoking with oropharyngeal and oral tongue cancers: pooled analysis from the INHANCE consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · January 2014 BACKGROUND: The incidence of oropharyngeal and oral tongue cancers has increased over the last 20 years which parallels increased use of marijuana among individuals born after 1950. METHODS: A pooled analysis was conducted comprising individual-level data ... Full text Link to item Cite

Potentially functional variants of p14ARF are associated with HPV-positive oropharyngeal cancer patients and survival after definitive chemoradiotherapy.

Journal Article Carcinogenesis · January 2014 Since p14 (ARF) and human papillomavirus (HPV) 16 E6/E7 oncoproteins are important regulators participating in the p53/Rb pathways, genetic variations of p14 (ARF) may modify tumor HPV16 status and survival of HPV16-positive squamous cell carcinoma of the ... Full text Link to item Cite

Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations.

Journal Article PLoS One · 2014 UNLABELLED: MicroRNAs are a new class of small non-protein-coding RNAs that sometimes function as tumor suppressors or oncogenes. Aberrant expression and structural alteration of microRNAs have been reported to be involved in tumorigenesis and cancer devel ... Full text Open Access Link to item Cite

Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking.

Journal Article Genet Epidemiol · December 2013 Neuronal nicotinic acetylcholine receptor (nAChR) genes (CHRNA5/CHRNA3/CHRNB4) have been reproducibly associated with nicotine dependence, smoking behaviors, and lung cancer risk. Of the few reports that have focused on early smoking behaviors, association ... Full text Link to item Cite

A NEIL1 single nucleotide polymorphism (rs4462560) predicts the risk of radiation-induced toxicities in esophageal cancer patients treated with definitive radiotherapy.

Journal Article Cancer · December 1, 2013 BACKGROUND: To assess the association between single nucleotide polymorphisms (SNPs) of base-excision repair genes and clinical outcomes, the roles of genetic variants of 3 selected genes-flap structure-specific endonuclease 1 (FEN1), 8-hydroxyguanine DNA ... Full text Link to item Cite

Genetic variations of mTORC1 genes and risk of gastric cancer in an Eastern Chinese population.

Journal Article Mol Carcinog · November 2013 Mammalian target of rapamycin complex 1 (mTORC1) plays an important role in maintaining proper cellular functions, and genetic variations in this complex may affect cancer risk. In this study, we examined the associations between eight potential functional ... Full text Link to item Cite

Gastric cancer-molecular and clinical dimensions.

Journal Article Nat Rev Clin Oncol · November 2013 Gastric cancer imposes a considerable health burden around the globe despite its declining incidence. The disease is often diagnosed in advanced stages and is associated with a poor prognosis for patients. An in-depth understanding of the molecular underpi ... Full text Link to item Cite

Associations of Lys939Gln and Ala499Val polymorphisms of the XPC gene with cancer susceptibility: a meta-analysis.

Journal Article Int J Cancer · October 15, 2013 XPC polymorphisms may alter DNA repair capacity, thus leading to genetic instability and carcinogenesis. Numerous studies have investigated the associations of XPC Lys939Gln (rs2228001) and Ala499Val (rs2228000) polymorphisms with cancer susceptibility; ho ... Full text Link to item Cite

Telomere length in peripheral blood lymphocytes contributes to the development of HPV-associated oropharyngeal carcinoma.

Journal Article Cancer Res · October 1, 2013 Sexual transmission of human papillomavirus (HPV), particularly HPV16, has been associated with an increasing incidence of oropharyngeal squamous cell carcinoma (OPC). Telomere shortening results in chromosomal instability, subsequently leading to cancer d ... Full text Link to item Cite

Differences in imaging characteristics of HPV-positive and HPV-Negative oropharyngeal cancers: a blinded matched-pair analysis.

Journal Article AJNR Am J Neuroradiol · October 2013 BACKGROUND AND PURPOSE: Human papillomavirus-positive oropharyngeal cancers typically have younger age of onset, limited tobacco exposure, and more favorable prognosis than HPV-negative oropharyngeal cancers. We assessed whether HPV-positive and HPV-negati ... Full text Link to item Cite

Cigarette, cigar, and pipe smoking and the risk of head and neck cancers: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.

Journal Article Am J Epidemiol · September 1, 2013 Cigar and pipe smoking are considered risk factors for head and neck cancers, but the magnitude of effect estimates for these products has been imprecisely estimated. By using pooled data from the International Head and Neck Cancer Epidemiology (INHANCE) C ... Full text Link to item Cite

Variants in nucleotide excision repair core genes and susceptibility to recurrence of squamous cell carcinoma of the oropharynx.

Journal Article Int J Cancer · August 1, 2013 Genetically determined capacity for NER may modulate both cancer risk and prognosis. Thus, we evaluated associations of seven selected variants in the NER core genes with recurrence risk in 658 squamous cell carcinoma of the oropharynx (SCCOP) patients tre ... Full text Link to item Cite

Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma.

Journal Article Mol Cancer · July 19, 2013 BACKGROUND: Tumor necrosis factor alpha (TNF-α) plays an important role in inflammation, immunity, and defense against infection and clearance of human papillomavirus (HPV). Thus, genetic variants may modulate individual susceptibility to HPV-associated or ... Full text Open Access Link to item Cite

Incidence and pattern of second primary malignancies in patients with index oropharyngeal cancers versus index nonoropharyngeal head and neck cancers.

Journal Article Cancer · July 15, 2013 BACKGROUND: A recent review of the Surveillance, Epidemiology, and End Results registry suggested that patients with index squamous cell carcinoma (SCC) of the oropharynx (SCCOP) are less likely to develop second primary malignancies (SPM) than patients wi ... Full text Link to item Cite

Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.

Journal Article Hum Mol Genet · July 15, 2013 Aiming to identify novel genetic loci for pigmentation and skin cancer, we conducted a series of genome-wide association studies on hair color, eye color, number of sunburns, tanning ability and number of non-melanoma skin cancers (NMSCs) among 10 183 Euro ... Full text Link to item Cite

Association between a rare novel TP53 variant (rs78378222) and melanoma, squamous cell carcinoma of head and neck and lung cancer susceptibility in non-Hispanic Whites.

Journal Article J Cell Mol Med · July 2013 Recently, several studies have investigated the association between a newly reported rare functional single nucleotide polymorphism (SNP) in TP53 (rs78378222) and cancer risk, but generated inconsistent findings. The present study further investigated this ... Full text Open Access Link to item Cite

Obesity-related genetic variants, human pigmentation, and risk of melanoma.

Journal Article Hum Genet · July 2013 Previous biological studies showed evidence of a genetic link between obesity and pigmentation in both animal models and humans. Our study investigated the individual and joint associations between obesity-related single nucleotide polymorphisms (SNPs) and ... Full text Link to item Cite

Genetic variants in p53-related genes confer susceptibility to second primary malignancy in patients with index squamous cell carcinoma of head and neck.

Journal Article Carcinogenesis · July 2013 Because of their important roles in mediating the stabilization and expression of p53, we hypothesized that high-risk genotypes of polymorphisms in p53-related genes, including p53, p73, p14(ARF), MDM2 and MDM4, may be associated with an increased risk of ... Full text Link to item Cite

Polymorphisms of nucleotide excision repair genes predict melanoma survival.

Journal Article J Invest Dermatol · July 2013 Melanoma is the most highly malignant skin cancer, and nucleotide excision repair (NER) is involved in melanoma susceptibility. In this analysis of 1,042 melanoma patients, we evaluated whether genetic variants of NER genes may predict survival outcome of ... Full text Open Access Link to item Cite

Polymorphisms in mTORC1 genes modulate risk of esophageal squamous cell carcinoma in eastern Chinese populations.

Journal Article J Thorac Oncol · June 2013 INTRODUCTION: Mammalian target of rapamycin complex 1 (mTORC1) is an evolutionary conserved multiprotein complex that functions as a key regulator of gene transcription, protein translation, and autophagy. No studies have assessed associations between func ... Full text Link to item Cite

DNA polymerase ζ as a potential biomarker of chemoradiation resistance and poor prognosis for cervical cancer.

Journal Article Med Oncol · June 2013 DNA Polymerase ζ (Polζ), an error-prone DNA polymerase involved in translesion DNA synthesis, plays a significant role in the cytotoxicity, mutagenicity, and chemoresistance of several cancers. To evaluate the association of Polζ with chemoradiation resist ... Full text Link to item Cite

Low risk of second primary malignancies among never smokers with human papillomavirus-associated index oropharyngeal cancers.

Journal Article Head Neck · June 2013 BACKGROUND: Among patients with index oropharyngeal cancer, second primary malignancies (SPMs) may be less common in cases of human papillomavirus (HPV)-associated tumors than HPV-negative tumors. Further modification of these SPM risks by smoking has not ... Full text Link to item Cite

Interleukin-10 promoter variants predict HPV-positive tumors and survival of squamous cell carcinoma of the oropharynx.

Journal Article FASEB J · June 2013 Interleukin-10 (IL-10) plays an important role in a host's defense against human papillomavirus (HPV) infection. IL-10 promoter variants may affect its expression level or functional efficiency and, subsequently, susceptibility to and survival of HPV16-ass ... Full text Link to item Cite

Gene variants in angiogenesis and lymphangiogenesis and cutaneous melanoma progression.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2013 BACKGROUND: Angiogenesis and lymphangiogenesis are important in the progression of melanoma. We investigated associations between genetic variants in these pathways with sentinel lymph node (SLN) metastasis and mortality in 2 independent series of patients ... Full text Link to item Cite

Association between putative functional variants in the PSMB9 gene and risk of melanoma--re-analysis of published melanoma genome-wide association studies.

Journal Article Pigment Cell Melanoma Res · May 2013 To mine possibly hidden causal single-nucleotide polymorphisms (SNPs) of melanoma, we investigated the association of SNPs in 76 M/G1 transition genes with melanoma risk using our published genome-wide association study (GWAS) data set with 1804 melanoma c ... Full text Link to item Cite

Variants in melanocortin 1 receptor gene contribute to risk of melanoma--a direct sequencing analysis in a Texas population.

Journal Article Pigment Cell Melanoma Res · May 2013 In this study, we directly sequenced the Melanocortin 1 Receptor (MC1R) gene in 2,212 individuals to detect all variants and assessed their associations with cutaneous melanoma (CM) risk in a hospital-based study of 1,106 CM patients and 1,106 control subj ... Full text Link to item Cite

Significance of MDM2 and P14 ARF polymorphisms in susceptibility to differentiated thyroid carcinoma.

Journal Article Surgery · May 2013 BACKGROUND: Murine double minute 2 (MDM2) oncoprotein and p14(ARF) tumor suppressor play pivotal roles in regulating p53 and function in the MAPK pathway, which is mutated frequently in differentiated thyroid carcinoma (DTC). We hypothesized that functiona ... Full text Link to item Cite

Steroid 5-alpha-reductase type 2 (SRD5A2) V89L and A49T polymorphisms and sporadic prostate cancer risk: a meta-analysis.

Journal Article Mol Biol Rep · May 2013 Steroid 5-α-reductase type 2 (SRD5A2) V89L and A49T polymorphisms are thought to play a crucial role in the androgen synthesis and metabolic pathway, but their associations with prostate cancer risk remain controversial. To provide a more precise estimatio ... Full text Link to item Cite

Pre-microRNA variants predict HPV16-positive tumors and survival in patients with squamous cell carcinoma of the oropharynx.

Journal Article Cancer Lett · April 28, 2013 To identify non-tumor biomarkers for prediction of tumor HPV status and prognosis of patients with squamous cell carcinoma of the oropharynx (SCCOP), we evaluated the association of single nucleotide polymorphisms (SNPs) in pre-miRNAs with HPV16 status and ... Full text Link to item Cite

Functional promoter variant rs2868371 of HSPB1 is associated with risk of radiation pneumonitis after chemoradiation for non-small cell lung cancer.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2013 PURPOSE: To date, no biomarkers have been found to predict, before treatment, which patients will develop radiation pneumonitis (RP), a potentially fatal toxicity, after chemoradiation for lung cancer. We investigated potential associations between single ... Full text Link to item Cite

A variant in FTO shows association with melanoma risk not due to BMI.

Journal Article Nat Genet · April 2013 We report the results of an association study of melanoma that is based on the genome-wide imputation of the genotypes of 1,353 cases and 3,566 controls of European origin conducted by the GenoMEL consortium. This revealed an association between several SN ... Full text Link to item Cite

Functional variants in TNFAIP8 associated with cervical cancer susceptibility and clinical outcomes.

Journal Article Carcinogenesis · April 2013 Tumor necrosis factor-α-induced protein 8 (TNFAIP8) is an anti apoptotic and pro-oncogenic signaling molecule involved in the process of immunity, carcinogenesis and tumor progression. Single nucleotide polymorphisms (SNPs) at microRNA-binding sites may ch ... Full text Link to item Cite

Association between functional polymorphisms in genes involved in the MAPK signaling pathways and cutaneous melanoma risk.

Journal Article Carcinogenesis · April 2013 Genome-wide association studies (GWASs) have mainly focused on top significant single nucleotide polymorphisms (SNPs), most of which did not have clear biological functions but were just surrogates for unknown causal variants. Studying SNPs with modest ass ... Full text Link to item Cite

A functional variant at the miR-885-5p binding site of CASP3 confers risk of both index and second primary malignancies in patients with head and neck cancer.

Journal Article FASEB J · April 2013 Caspases are important regulators and executioners in the apoptosis pathways and play crucial roles in carcinogenesis. We tested the hypothesis that functional variants of CASP genes are associated with risk of squamous cell carcinoma of the head and neck ... Full text Link to item Cite

Functional repeats (TGYCC)n in the p53-inducible gene 3 (PIG3) promoter and susceptibility to squamous cell carcinoma of the head and neck.

Journal Article Carcinogenesis · April 2013 A polymorphic pentanucleotide microsatellite sequence (TGYCC)n within the p53-inducible gene 3 (PIG3) promoter is correlated with the extent of transcriptional activation by p53 and thought to modulate susceptibility to cancer. Using a PCR-silver staining- ... Full text Link to item Cite

ATM polymorphisms predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2013 PURPOSE: The ataxia telangiectasia mutated (ATM) gene mediates detection and repair of DNA damage. We investigated associations between ATM polymorphisms and severe radiation-induced pneumonitis (RP). METHODS AND MATERIALS: We genotyped 3 potentially funct ... Full text Link to item Cite

Polymorphisms of the Interleukin 6 gene contribute to cervical cancer susceptibility in Eastern Chinese women.

Journal Article Hum Genet · March 2013 Interleukin 6 (IL6) encodes a cytokine protein, which functions in inflammation, maintains immune homeostasis and plays important roles in cervical carcinogenesis. Single nucleotide polymorphisms (SNPs) in IL6 that cause variations in host immune response ... Full text Link to item Cite

Etiology and risk factors

Chapter · March 1, 2013 Full text Cite

Osteoradionecrosis and radiation dose to the mandible in patients with oropharyngeal cancer.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2013 PURPOSE: To determine the association between radiation doses delivered to the mandible and the occurrence of osteoradionecrosis (ORN). METHODS AND MATERIALS: We reviewed the records of 402 oropharyngeal cancer patients with stage T1 or T2 disease treated ... Full text Link to item Cite

A pri-miR-218 variant and risk of cervical carcinoma in Chinese women.

Journal Article BMC Cancer · January 15, 2013 BACKGROUND: MicroRNA (miRNA)-related single nucleotide polymorphisms (SNPs) may compromise miRNA binding affinity and modify mRNA expression levels of the target genes, thus leading to cancer susceptibility. However, few studies have investigated roles of ... Full text Open Access Link to item Cite

REV3L 3'UTR 460 T>C polymorphism in microRNA target sites contributes to lung cancer susceptibility.

Journal Article Oncogene · January 10, 2013 REV3Lp, the catalytic subunit of DNA polymerase zeta, is the major participant in translesion DNA synthesis. Recent evidence suggests that REV3L has an important role in the maintenance of genome stability despite its mutagenic characteristics. Such a func ... Full text Link to item Cite

PGC-1 coactivators regulate MITF and the tanning response.

Journal Article Mol Cell · January 10, 2013 The production of pigment by melanocytes tans the skin and protects against skin cancers. UV-exposed keratinocytes secrete α-MSH, which then activates melanin formation in melanocytes by inducing the microphthalmia-associated transcription factor (MITF). W ... Full text Link to item Cite

Genome-wide association study reveals novel genetic determinants of DNA repair capacity in lung cancer.

Journal Article Cancer Res · January 1, 2013 Suboptimal cellular DNA repair capacity (DRC) has been shown to be associated with enhanced cancer risk, but genetic variants affecting the DRC phenotype have not been comprehensively investigated. In this study, with the available DRC phenotype data, we a ... Full text Link to item Cite

Incorporating single-nucleotide polymorphisms into the Lyman model to improve prediction of radiation pneumonitis.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2013 PURPOSE: To determine whether single-nucleotide polymorphisms (SNPs) in genes associated with DNA repair, cell cycle, transforming growth factor-β, tumor necrosis factor and receptor, folic acid metabolism, and angiogenesis can significantly improve the fi ... Full text Link to item Cite

TGFβ1 Polymorphisms Predict Distant Metastasis-Free Survival in Patients with Inoperable Non-Small-Cell Lung Cancer after Definitive Radiotherapy.

Journal Article PLoS One · 2013 PURPOSE: Transforming growth factor (TGF) -β1 signaling is involved in cancer-cell metastasis. We investigated whether single nucleotide polymorphisms (SNPs) at TGFβ1 were associated with overall survival (OS) and distant metastasis-free survival (DMFS) in ... Full text Open Access Link to item Cite

MicroRNA variants increase the risk of HPV-associated squamous cell carcinoma of the oropharynx in never smokers.

Journal Article PLoS One · 2013 BACKGROUND: Both microRNAs and human papillomavirus (HPV) infection play an important role in the development and progression of oral squamous cell carcinoma (OSCC). In addition, microRNAs affect all facets of the immune/inflammation responses to infection ... Full text Open Access Link to item Cite

ERCC1 and ERCC2 variants predict survival in gastric cancer patients.

Journal Article PLoS One · 2013 PURPOSE: ERCC1 and ERCC2 play critical roles in the nucleotide excision repair pathway that effectively repairs DNA damage induced by chemotherapeutic agents. Therefore, functional single nucleotide polymorphisms (SNPs) in these genes could have an impact ... Full text Open Access Link to item Cite

Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population.

Journal Article PLoS One · 2013 BACKGROUND: Caspase 7 (CASP7) is an important regulator and executioner in the apoptosis pathway and plays a crucial role in cancer development and progression. However, few studies have evaluated associations between functional single nucleotide polymorph ... Full text Open Access Link to item Cite

Association of LEP G2548A and LEPR Q223R polymorphisms with cancer susceptibility: evidence from a meta-analysis.

Journal Article PLoS One · 2013 BACKGROUND: Numerous epidemiological studies have examined associations of genetic variations in LEP (G2548A, -2548 nucleotide upstream of the ATG start site) and LEPR (Q223R, nonsynonymous SNP in exon 6) with cancer susceptibility; however, the findings a ... Full text Open Access Link to item Cite

Joint effect of multiple common SNPs predicts melanoma susceptibility.

Journal Article PLoS One · 2013 Single genetic variants discovered so far have been only weakly associated with melanoma. This study aims to use multiple single nucleotide polymorphisms (SNPs) jointly to obtain a larger genetic effect and to improve the predictive value of a conventional ... Full text Open Access Link to item Cite

The miR-184 binding-site rs8126 T>C polymorphism in TNFAIP2 is associated with risk of gastric cancer.

Journal Article PLoS One · 2013 BACKGROUND: TNFAIP2 is a crucial gene involved in apoptosis. Single nucleotide polymorphisms (SNPs) in its miRNA binding sites could modulate functions of the miRNA-target genes and thus risk of cancers. In this study, we investigated associations between ... Full text Open Access Link to item Cite

Molecular epidemiology of DNA repair gene polymorphisms and head and neck cancer

Journal Article Journal of Biomedical Research · January 1, 2013 Although tobacco and alcohol consumption are two common risk factors of head and neck cancer (HNC), other specific etiologic causes, such as viral infection and genetic susceptibility factors, remain to be understood. Hu- man DNA is often damaged by numero ... Full text Cite

Polymorphisms in the mTOR gene and risk of sporadic prostate cancer in an Eastern Chinese population.

Journal Article PLoS One · 2013 BACKGROUND: The mTOR gene regulates cell growth by controlling mRNA translation, ribosome biogenesis, autophagy, and metabolism. Abnormally increased expression of mTOR was associated with carcinogenesis, and its functional single nucleotide polymorphisms ... Full text Open Access Link to item Cite

No association between TGFB1 polymorphisms and late radiotherapy toxicity: a meta-analysis.

Journal Article PLoS One · 2013 BACKGROUND: Transforming growth factor-beta 1 (TGF-β1) protein may be multifunctional and related to the development of fibrosis, induction of apoptosis, extracellular signaling and inhibition of proliferation in response to radiation-induced DNA damage. S ... Full text Open Access Link to item Cite

Prognosis significance of HER-2/neu overexpression/amplification in Chinese patients with curatively resected gastric cancer after the ToGA clinical trial.

Journal Article World J Surg Oncol · December 18, 2012 BACKGROUND: HER-2/neu-targeted therapy has been successfully used in advanced gastric cancer, but the role of HER-2/neu in the prognosis of gastric cancer is not yet clear. In this study, we investigated the correlation between HER-2/neu expression and amp ... Full text Open Access Link to item Cite

Single nucleotide polymorphisms

Chapter · December 7, 2012 Cite

Association between single nucleotide polymorphisms of the transforming growth factor β1 gene and the risk of severe radiation esophagitis in patients with lung cancer.

Journal Article Radiother Oncol · December 2012 PURPOSE: We investigated the association between single nucleotide polymorphisms (SNPs) in the transforming growth factor β1 (TGFβ1) gene and the risk of radiation-induced esophageal toxicity (RE) in patients with non-small-cell lung cancer (NSCLC). METHOD ... Full text Link to item Cite

Nucleotide-excision repair deficiency: Acausative factor for accelerated aging diseases in humans?

Journal Article · December 1, 2012 Nucleotide excision repair (NER) recognizes and removes bulky DNA damage that leads to DNA double-helix distortion. Inherited defects in the NER pathway have been associated with aging symptoms and premature death. In this review, we discussed the mechanis ... Cite

Combined effects of E2F1 and E2F2 polymorphisms on risk and early onset of squamous cell carcinoma of the head and neck.

Journal Article Mol Carcinog · October 2012 Deregulated expression of most members of the E2F family has been detected in many human cancers. We examined the association of common single nucleotide polymorphisms (SNPs) of E2F transcription factors 1 and 2 (E2F1 and E2F2) with risk of squamous cell c ... Full text Link to item Cite

Genetic variants of a BH3-only pro-apoptotic gene, PUMA, and risk of HPV16-associated squamous cell carcinoma of the head and neck.

Journal Article Mol Carcinog · October 2012 P53 up-regulated modulator of apoptosis (PUMA) is a critical factor in the intrinsic apoptotic pathway. Through PUMA-dependent mechanisms, human papillomavirus 16 (HPV16) oncoprotein may affect apoptosis by E6-mediated p53 degradation. To examine whether t ... Full text Link to item Cite

HSPB1 gene polymorphisms predict risk of mortality for US patients after radio(chemo)therapy for non-small cell lung cancer.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2012 PURPOSE: We investigated potential associations between single-nucleotide polymorphisms (SNPs) in the heat shock protein beta-1 (HSPB1) gene and overall survival in US patients with non-small cell lung cancer (NSCLC). METHODS AND MATERIALS: Using available ... Full text Link to item Cite

Functional polymorphisms in the insulin-like binding protein-3 gene may modulate susceptibility to differentiated thyroid carcinoma in Caucasian Americans.

Journal Article Mol Carcinog · October 2012 The insulin-like growth factor (IGF) pathway is believed to play a pivotal role in thyroid carcinogenesis. Polymorphisms of IGF-1 and IGF binding protein-3 (IGFBP-3) have been associated with modulation of risk for the emergence of assorted common malignan ... Full text Link to item Cite

Single nucleotide polymorphisms of matrix metallopeptidase 3 and risk of gliomas in a Chinese Han population.

Journal Article Mol Carcinog · October 2012 Matrix metallopeptidases (MMPs) play an important role in central nervous system tumor growth, invasion and spreading. The currently available data provide clear evidence for the involvement of MMP3 in the pathophysiology of glioma. The study aims to explo ... Full text Link to item Cite

Association of CASP7 polymorphisms and survival of patients with non-small cell lung cancer with platinum-based chemotherapy treatment.

Journal Article Chest · September 2012 BACKGROUND: CASP7 plays a crucial role in cancer development and chemotherapy efficacy. We, therefore, explored whether single nucleotide polymorphisms (SNPs) of the CASP7 gene can modulate outcomes of patients with advanced non-small cell lung cancer (NSC ... Full text Link to item Cite

Functional single-nucleotide polymorphisms in the BRCA1 gene and risk of salivary gland carcinoma.

Journal Article Oral Oncol · September 2012 OBJECTIVES: Polymorphic BRCA1 is a vital tumor suppressor gene within the DNA double-strand break repair pathways, but its association with salivary gland carcinoma (SGC) has yet to be investigated. MATERIALS AND METHODS: In a case-control study of 156 SGC ... Full text Link to item Cite

Combined p53-related genetic variants together with HPV infection increase oral cancer risk.

Journal Article Int J Cancer · August 1, 2012 To explore the role of polymorphisms of p53-related genes in etiology of oral cancer, we investigated joint effects of seven putatively functional polymorphisms of p53 (codon 72 Arg/Pro), p73 (4/14 GC/AT), murine double minute 2 gene (MDM2; A2164G and T258 ... Full text Link to item Cite

Genome-wide gene-environment interaction analysis for asbestos exposure in lung cancer susceptibility.

Journal Article Carcinogenesis · August 2012 Asbestos exposure is a known risk factor for lung cancer. Although recent genome-wide association studies (GWASs) have identified some novel loci for lung cancer risk, few addressed genome-wide gene-environment interactions. To determine gene-asbestos inte ... Full text Open Access Link to item Cite

Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers.

Journal Article Arch Gen Psychiatry · August 2012 CONTEXT: Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968. OBJECTIVE: To determine whether the association between rs16969968 and smoking is modified by age a ... Full text Link to item Cite

Neighborhood deprivation and clinical outcomes among head and neck cancer patients.

Journal Article Health Place · July 2012 The unique effects of neighborhood-level economic deprivation on survival, recurrence, and second primary malignancy development were examined using adjusted Cox proportional hazards regression models among 1151 incident squamous cell carcinomas of the hea ... Full text Link to item Cite

Polymorphisms in the XPG gene and risk of gastric cancer in Chinese populations.

Journal Article Hum Genet · July 2012 DNA repair genes play an important role in maintaining stability and integrity of genomic DNA. Polymorphisms in nucleotide excision repair genes may cause variations in DNA repair capacity phenotype and thus contribute to cancer risk. In this case-control ... Full text Link to item Cite

Putatively functional PLCE1 variants and susceptibility to esophageal squamous cell carcinoma (ESCC): a case-control study in eastern Chinese populations.

Journal Article Ann Surg Oncol · July 2012 BACKGROUND: A novel variant rs2274223 located in the phospholipase C epsilon 1 (PLCE1) gene was found to be associated with risk of esophageal squamous cell carcinoma (ESCC) by 2 large-scale genome-wide association studies (GWASs) in Chinese populations. I ... Full text Link to item Cite

Functional variations in the ATM gene and susceptibility to differentiated thyroid carcinoma.

Journal Article J Clin Endocrinol Metab · June 2012 CONTEXT: ATM is critical in response to ionizing radiation-induced DNA damage. OBJECTIVE: Variations in ATM are hypothesized to affect individual susceptibility to thyroid cancer. Our objective was to evaluate the association between ATM polymorphisms and ... Full text Link to item Cite

Detectable clonal mosaicism from birth to old age and its relationship to cancer.

Journal Article Nat Genet · May 6, 2012 We detected clonal mosaicism for large chromosomal anomalies (duplications, deletions and uniparental disomy) using SNP microarray data from over 50,000 subjects recruited for genome-wide association studies. This detection method requires a relatively hig ... Full text Open Access Link to item Cite

Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck.

Journal Article BMC Cancer · May 1, 2012 BACKGROUND: The cooperation between phorbol 12-myristate 13-acetate induced protein 1 (NOXA) and myeloid cell leukemia 1 (MCL1) is critical in the intrinsic apoptotic pathway. Human papillomavirus 16 (HPV16), by inducing p53 and pRb-E2F degradation, may pl ... Full text Open Access Link to item Cite

p73 G4C14-to-A4T14 gene polymorphism and interaction with p53 exon 4 Arg72Pro on cancer susceptibility: a meta-analysis of the literature.

Journal Article Mutagenesis · May 2012 The p73 gene (1p36-33) is involved in cancer development through cell growth inhibition by inducing apoptosis in a p53-like manner. The p73 G4C14-to-A4T14 dinucleotide polymorphism, consisting of two single-nucleotide polymorphisms in the non-coding region ... Full text Link to item Cite

Polymorphisms of the vascular endothelial growth factor gene and severe radiation pneumonitis in non-small cell lung cancer patients treated with definitive radiotherapy.

Journal Article Cancer Sci · May 2012 Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis and lung cancer progression. We hypothesized that VEGF polymorphisms may modulate the risk of radiation pneumonitis (RP) in non-small cell lung cancer (NSCLC) patients treated wi ... Full text Link to item Cite

Reply to K.A. Olaussen et al

Journal Article Journal of Clinical Oncology · May 1, 2012 Full text Cite

A meta-analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lymphoblastic leukemia in children.

Journal Article Pediatr Blood Cancer · April 2012 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms have been implicated in childhood acute lymphoblastic leukemia (ALL) risk, but previously published studies were inconsistent and recent meta-analyses were not adequate. ... Full text Link to item Cite

Gamma-ray-induced mutagen sensitivity and risk of sporadic breast cancer in young women: a case-control study.

Journal Article Breast Cancer Res Treat · April 2012 Hypersensitivity to radiation exposure has been suggested to be a risk factor for the development of breast cancer. In this case-control study of 515 young women (≤ 55 years) with newly diagnosed sporadic breast cancer and 402 cancer-free controls, we exam ... Full text Link to item Cite

Influence of single nucleotide polymorphisms in the MMP1 promoter region on cutaneous melanoma progression.

Journal Article Melanoma Res · April 2012 Recently, we reported on the associations of seven single nucleotide polymorphisms (SNPs) in the promoter region of MMP1 gene with susceptibility to cutaneous melanoma (CM). Considering the reported correlation between MMP1 expression and melanoma progress ... Full text Link to item Cite

Serum microRNA profiling and breast cancer risk: the use of miR-484/191 as endogenous controls.

Journal Article Carcinogenesis · April 2012 It has been demonstrated that there are abundant stable microRNAs (miRNAs) in plasma/serum, which can be detected and are potentially disease specific. However, the lack of suitable endogenous controls for serum miRNA detection is the restriction for the w ... Full text Link to item Cite

Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck.

Journal Article Mol Cancer · March 26, 2012 BACKGROUND: Cell cycle deregulation is common in human cancer, and alterations of p27 and p21, two critical cell cycle regulators, have been implicated in the development of many human malignancies. Therefore, we hypothesize that p27 T109G polymorphism ind ... Full text Open Access Link to item Cite

Modifying effect of MDM4 variants on risk of HPV16-associated squamous cell carcinoma of oropharynx.

Journal Article Cancer · March 15, 2012 BACKGROUND: The p53 pathway plays a critical role in maintaining genomic stability and preventing tumor formation. Given the roles of both MDM4 and HPV16 E6 oncoproteins in inhibition of p53 activity, we tested the hypothesis that MDM4 polymorphisms are as ... Full text Link to item Cite

Exonuclease 1 (EXO1) gene variation and melanoma risk.

Journal Article DNA Repair (Amst) · March 1, 2012 OBJECTIVE: DNA repair pathway genes play an important role in maintaining genomic integrity and protecting against cancer development. This study aimed to identify novel SNPs in the DNA repair-related genes associated with melanoma risk from a genome-wide ... Full text Link to item Cite

Family history of cancer and risk of sporadic differentiated thyroid carcinoma.

Journal Article Cancer · March 1, 2012 BACKGROUND: Thyroid cancer incidence in the United States, particularly in women, has increased dramatically since the 1980s. Although the causes of thyroid cancer in most patients remain largely unknown, evidence suggests the existence of an inherited pre ... Full text Link to item Cite

Roles of genetic variants in the PI3K and RAS/RAF pathways in susceptibility to endometrial cancer and clinical outcomes.

Journal Article J Cancer Res Clin Oncol · March 2012 PURPOSE: The phosphatidylinositol 3-kinase (PI3K)/PTEN/AKT/mTOR and Ras/Raf/MEK/ERK pathways have been implicated in endometrial tumorigenesis. In this candidate pathway analysis, we investigated associations between genetic variations in these two pathway ... Full text Link to item Cite

Genetic variants of the nonhomologous end joining gene LIG4 and severe radiation pneumonitis in nonsmall cell lung cancer patients treated with definitive radiotherapy.

Journal Article Cancer · January 15, 2012 BACKGROUND: Nonhomologous end joining (NHEJ) is a pathway that repairs DNA double-strand breaks (DSBs) to maintain genomic stability in response to irradiation. The authors hypothesized that single nucleotide polymorphisms (SNPs) in NHEJ repair genes may a ... Full text Link to item Cite

Genetic variants of the p53 and p73 genes jointly increase risk of second primary malignancies in patients after index squamous cell carcinoma of the head and neck.

Journal Article Cancer · January 15, 2012 BACKGROUND: Because of the structural and biochemical similarities between the antitumor p53 and p73 proteins, the authors hypothesized that individuals who carry high-risk genotypes of p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms have a higher risk o ... Full text Link to item Cite

Association between single nucleotide polymorphisms in ERCC4 and risk of squamous cell carcinoma of the head and neck.

Journal Article PLoS One · 2012 BACKGROUND: Excision repair cross-complementation group 4 gene (ERCC4/XPF) plays an important role in nucleotide excision repair and participates in removal of DNA interstrand cross-links and DNA double-strand breaks. Single nucleotide polymorphisms (SNPs) ... Full text Open Access Link to item Cite

Correlation between base-excision repair gene polymorphisms and levels of in-vitro BPDE-induced DNA adducts in cultured peripheral blood lymphocytes.

Journal Article PLoS One · 2012 In vitro benzo[a]pyrene diol epoxide (BPDE)-induced DNA adducts in cultured peripheral lymphocytes have been shown to be a phenotypic biomarker of individual's DNA repair phenotype that is associated with cancer risk. In this study, we explored association ... Full text Open Access Link to item Cite

Polymorphisms of XPG/ERCC5 and risk of squamous cell carcinoma of the head and neck.

Journal Article Pharmacogenet Genomics · January 2012 OBJECTIVES: Xeroderma pigmentosum group G (XPG) protein is essential for the nucleotide excision repair system, and genetic variations in XPG/ERCC5 that affect DNA repair capacity may contribute to the risk of tobacco-induced cancers, including squamous ce ... Full text Link to item Cite

A functional NQO1 609C>T polymorphism and risk of gastrointestinal cancers: a meta-analysis.

Journal Article PLoS One · 2012 BACKGROUND: The functional polymorphism (rs1800566) in the NQO1 gene, a 609C>T substitution, leading to proline-to-serine amino-acid and enzyme activity changes, has been implicated in cancer risk, but individually published studies showed inconclusive res ... Full text Open Access Link to item Cite

Association between CASP8 and CASP10 polymorphisms and toxicity outcomes with platinum-based chemotherapy in Chinese patients with non-small cell lung cancer.

Journal Article Oncologist · 2012 Caspase-8 and caspase-10 play crucial roles in both cancer development and chemotherapy efficacy. In this study, we aimed to comprehensively assess single nucleotide polymorphisms (SNPs) of the caspase-8 (CASP8) and caspase-10 (CASP10) genes in relation to ... Full text Link to item Cite

Association between PARP-1 V762A polymorphism and cancer susceptibility: a meta-analysis.

Journal Article Genet Epidemiol · January 2012 Poly(ADP-ribose) polymerase-1 (PARP-1 catalyzes poly(ADP-ribosyl)ation to various proteins involved in many cellular processes, including DNA damage detection and repair and cell proliferation and death. PARP-1 has been implicated in human carcinogenesis, ... Full text Link to item Cite

Association between XPF polymorphisms and cancer risk: a meta-analysis.

Journal Article PLoS One · 2012 BACKGROUND: Xeroderma pigmentosum complementation group F (XPF or ERCC4) plays a key role in DNA repair that protects against genetic instability and carcinogenesis. A series of epidemiological studies have examined associations between XPF polymorphisms a ... Full text Open Access Link to item Cite

Association between the ERCC5 Asp1104His polymorphism and cancer risk: a meta-analysis.

Journal Article PLoS One · 2012 BACKGROUND: Excision repair cross complementing group 5 (ERCC5 or XPG) plays an important role in regulating DNA excision repair, removal of bulky lesions caused by environmental chemicals or UV light. Mutations in this gene cause a rare autosomal recessiv ... Full text Open Access Link to item Cite

Association of BRCA1 functional single nucleotide polymorphisms with risk of differentiated thyroid carcinoma.

Journal Article Thyroid · January 2012 BACKGROUND: Breast cancer 1, early onset (BRCA1) is a vital DNA repair gene, and the single nucleotide polymorphisms (SNPs) of this gene have been studied in diverse cancer types. In this study, we investigated the association between eight common BRCA1 fu ... Full text Link to item Cite

Association of combined p73 and p53 genetic variants with tumor HPV16-positive oropharyngeal cancer.

Journal Article PLoS One · 2012 p53 and p73 interact with human papillomavirus (HPV) E6 and E7 oncoproteins. The interplay between p53 and p73 and HPV16 may lead to deregulation of cell cycle and apoptosis, through which inflammation/immune responses control the HPV clearance and escape ... Full text Open Access Link to item Cite

Effect of polymorphisms in XPD on clinical outcomes of platinum-based chemotherapy for Chinese non-small cell lung cancer patients.

Journal Article PLoS One · 2012 PURPOSE: Xeroderma pigmentosum group D (XPD) codes for a DNA helicase involved in nucleotide excision repair that removes platinum-induced DNA damage. Genetic polymorphisms of XPD may affect DNA repair capacity and lead to individual differences in the out ... Full text Open Access Link to item Cite

Functional polymorphisms of CHRNA3 predict risks of chronic obstructive pulmonary disease and lung cancer in Chinese.

Journal Article PLoS One · 2012 Recently, several genome-wide association studies (GWAS) have identified many susceptible single nucleotide polymorphisms (SNPs) for chronic obstructive pulmonary disease (COPD) and lung cancer which are two closely related diseases. Among those SNPs, some ... Full text Open Access Link to item Cite

Genetic variation in MDM2 and p14ARF and susceptibility to salivary gland carcinoma.

Journal Article PLoS One · 2012 BACKGROUND: The p14(ARF)/MDM2/p53 pathway plays an important role in modulation of DNA damage and oxidative stress responses. The aim of this study was to determine whether genetic variants in MDM2 and p14(ARF) are associated with risk of salivary gland ca ... Full text Open Access Link to item Cite

No association between Parkinson disease alleles and the risk of melanoma.

Journal Article Cancer Epidemiol Biomarkers Prev · January 2012 BACKGROUND: Recent data showed that melanoma was more common among patients with Parkinson disease than individuals without Parkinson disease and vice versa. It has been hypothesized that these two diseases may share common genetic and environmental risk f ... Full text Link to item Cite

On the interplay of telomeres, nevi and the risk of melanoma.

Journal Article PLoS One · 2012 The relationship between telomeres, nevi and melanoma is complex. Shorter telomeres have been found to be associated with many cancers and with number of nevi, a known risk factor for melanoma. However, shorter telomeres have also been found to decrease me ... Full text Open Access Link to item Cite

Polymorphisms in ERCC1 and XPF genes and risk of gastric cancer in an eastern Chinese population.

Journal Article PLoS One · 2012 BACKGROUND: Inherited functional single nucleotide polymorphisms (SNPs) in DNA repair genes may alter DNA repair capacity and thus contribute to cancer risk. METHODS: Three ERCC1 functional SNPs (rs2298881C>A, rs3212986C>A and rs11615G>A) and two XPF/ERCC4 ... Full text Open Access Link to item Cite

Polymorphisms in the ERCC5 gene and risk of esophageal squamous cell carcinoma (ESCC) in Eastern Chinese populations.

Journal Article PLoS One · 2012 BACKGROUND: Excision repair cross complementing group 5 (ERCC5 or XPG) plays an important role in regulating DNA excision repair; its functional single nucleotide polymorphisms (SNPs) may alter DNA repair capacity and thus contribute to cancer risk. METHOD ... Full text Open Access Link to item Cite

Potentially functional variants of PLCE1 identified by GWASs contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population.

Journal Article PLoS One · 2012 BACKGROUND: Recent genome-wide association studies (GWAS) have found a single nucleotide polymorphism (SNP, rs2274223 A>G) in PLCE1 to be associated with risk of gastric adenocarcinoma. In the present study, we validated this finding and also explored the ... Full text Open Access Link to item Cite

RAD52 variants predict platinum resistance and prognosis of cervical cancer.

Journal Article PLoS One · 2012 RAD52 is an important but not well characterized homologous recombination repair gene that can bind to single-stranded DNA ends and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. To evaluate the role of RAD52 vari ... Full text Open Access Link to item Cite

Tumor necrosis factor-α induced protein 8 polymorphism and risk of non-Hodgkin's lymphoma in a Chinese population: a case-control study.

Journal Article PLoS One · 2012 BACKGROUND: Non-Hodgkin's lymphoma (NHL) has been reported to be associated with autoimmune and pro-inflammatory response, and genetic polymorphisms of candidate genes involved in autoimmune and pro-inflammatory response may influence the susceptibility to ... Full text Open Access Link to item Cite

Genome-wide association study identifies novel loci predisposing to cutaneous melanoma.

Journal Article Hum Mol Genet · December 15, 2011 We performed a multistage genome-wide association study of melanoma. In a discovery cohort of 1804 melanoma cases and 1026 controls, we identified loci at chromosomes 15q13.1 (HERC2/OCA2 region) and 16q24.3 (MC1R) regions that reached genome-wide significa ... Full text Link to item Cite

Telomere length and TERT functional polymorphisms are not associated with risk of squamous cell carcinoma of the head and neck.

Journal Article Cancer Epidemiol Biomarkers Prev · December 2011 BACKGROUND: Recent studies reported associations of the relative telomere length (RTL) and TERT variants with risk of several cancers, which have not been comprehensively investigated in squamous cell carcinoma of the head and neck (SCCHN). METHODS: We det ... Full text Link to item Cite

Sequence variants and the risk of head and neck cancer: Pooled analysis in the INHANCE consortium

Journal Article Frontiers in Oncology · December 1, 2011 Previous molecular epidemiological studies on head and neck cancer have examined various single nucleotide polymorphisms (SNPs), but there are very few documented associations. In the International head and neck cancer epidemiology (INHANCE) consortium, we ... Full text Cite

A functional variant at the miR-184 binding site in TNFAIP2 and risk of squamous cell carcinoma of the head and neck.

Journal Article Carcinogenesis · November 2011 Although the role of TNFAIP2 is still unclear, it is an important gene involved in apoptosis, and there are single-nucleotide polymorphisms (SNPs) at its microRNA (miRNA)-binding sites that could modulate miRNA target gene function. In this study, we evalu ... Full text Link to item Cite

Functional polymorphisms of base excision repair genes XRCC1 and APEX1 predict risk of radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2011 PURPOSE: To explore whether functional single nucleotide polymorphisms (SNPs) of base-excision repair genes are predictors of radiation treatment-related pneumonitis (RP), we investigated associations between functional SNPs of ADPRT, APEX1, and XRCC1 and ... Full text Link to item Cite

Functional promoter rs2868371 variant of HSPB1 associates with radiation-induced esophageal toxicity in patients with non-small-cell lung cancer treated with radio(chemo)therapy.

Journal Article Radiother Oncol · November 2011 PURPOSE: We investigated the association between single-nucleotide polymorphisms (SNPs) in the heat shock protein beta-1 (HSPB1) gene and the risk of radiation-induced esophageal toxicity (RIET) in patients with non-small-cell lung cancer (NSCLC). MATERIAL ... Full text Link to item Cite

DNA repair capacity in peripheral lymphocytes predicts survival of patients with non-small-cell lung cancer treated with first-line platinum-based chemotherapy.

Journal Article J Clin Oncol · November 1, 2011 PURPOSE: Platinum-based regimens are the standard chemotherapy for patients with advanced non-small-cell lung cancer (NSCLC). DNA repair capacity (DRC) in tumor cells plays an important role in resistance to platinum-based drugs. We have previously reporte ... Full text Link to item Cite

Possible association between genetic variants in the H2AFX promoter region and risk of adult glioma in a Chinese Han population.

Journal Article J Neurooncol · November 2011 H2AFX, a histone H2A gene family member X, is a key component in the detection of and response to DNA double-strand breaks (DSBs) caused by ionizing radiation (IR), a known risk factor for glioma. Thus, genetic variants in the H2AFX promoter region that ma ... Full text Link to item Cite

TNFRSF1B +676 T>G polymorphism predicts survival of non-small cell lung cancer patients treated with chemoradiotherapy.

Journal Article BMC Cancer · October 14, 2011 BACKGROUND: The dysregulation of gene expression in the TNF-TNFR superfamily has been involved in various human cancers including non-small cell lung cancer (NSCLC). Furthermore, functional polymorphisms in TNF-α and TNFRSF1B genes that alter gene expressi ... Full text Open Access Link to item Cite

Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3.

Journal Article Nat Genet · October 9, 2011 We performed a genome-wide association study of melanoma in a discovery cohort of 2,168 Australian individuals with melanoma and 4,387 control individuals. In this discovery phase, we confirm several previously characterized melanoma-associated loci at MC1 ... Full text Open Access Link to item Cite

Genome-wide association study identifies three new melanoma susceptibility loci.

Journal Article Nat Genet · October 9, 2011 We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control individuals of European ancestry, as well as an additional 6, ... Full text Open Access Link to item Cite

Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma.

Journal Article Hum Mol Genet · September 15, 2011 We conducted a genome-wide association study on cutaneous basal cell carcinoma (BCC) among 2045 cases and 6013 controls of European ancestry, with follow-up replication in 1426 cases and 4845 controls. A non-synonymous SNP in the MC1R gene (rs1805007 encod ... Full text Link to item Cite

Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk.

Journal Article J Natl Cancer Inst · September 7, 2011 Genetic variations in the CYP2A6 nicotine metabolic gene and the CHRNA5-CHRNA3-CHRNB4 (CHRNA5-A3-B4) nicotinic gene cluster have been independently associated with lung cancer. With genotype data from ever-smokers of European ancestry (417 lung cancer pati ... Full text Link to item Cite

Effects of MDM2 promoter polymorphisms and p53 codon 72 polymorphism on risk and age at onset of squamous cell carcinoma of the head and neck.

Journal Article Mol Carcinog · September 2011 Both p53 tumor suppressor and murine double minute 2 (MDM2) oncoprotein are crucial in carcinogenesis. We hypothesized that MDM2 promoter single nucleotide polymorphisms (SNPs) SNP309 T > G, A2164G, and p53 codon 72 are associated with risk and age at onse ... Full text Link to item Cite

An examination of male and female odds ratios by BMI, cigarette smoking, and alcohol consumption for cancers of the oral cavity, pharynx, and larynx in pooled data from 15 case-control studies.

Journal Article Cancer Causes Control · September 2011 BACKGROUND: Greater tobacco smoking and alcohol consumption and lower body mass index (BMI) increase odds ratios (OR) for oral cavity, oropharyngeal, hypopharyngeal, and laryngeal cancers; however, there are no comprehensive sex-specific comparisons of ORs ... Full text Link to item Cite

[Human chromosome 8p11 (CHRNB3-CHRNA6) region gene polymorphisms and susceptibility to lung cancer in Chinese Han population].

Journal Article Yi Chuan · August 2011 To investigate the association between chromosome 8p11 (CHRNB3-CHRNA6) polymorphisms and lung cancer susceptibility in Chinese Han population, we genotyped 6 tag SNPs variants of this region among 784 patients with lung cancer and 782 age- and sex-matched ... Full text Link to item Cite

Polymorphisms of MDM4 and risk of squamous cell carcinoma of the head and neck.

Journal Article Pharmacogenet Genomics · July 2011 PURPOSE: Mouse double minute 4 (MDM4), a homolog of MDM2, is one of the key negative regulators of p53, and its amplification or overexpression contributes to carcinogenesis by inhibiting the p53 tumor suppressor activity. We investigated the association b ... Full text Link to item Cite

Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk.

Journal Article Hum Mol Genet · July 1, 2011 We conducted a genome-wide association study on the number of melanocytic nevi reported by 9136 individuals of European ancestry, with follow-up replication in 3581 individuals. We identified the nidogen 1 (NID1) gene on 1q42 associated with nevus count (t ... Full text Link to item Cite

Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck.

Journal Article BMC Cancer · June 20, 2011 BACKGROUND: Phospholipase C epsilon 1 (PLCE1) (an effector of Ras) belonging to the phospholipase family plays crucial roles in carcinogenesis and progression of several cancers, including squamous cell carcinoma of the head and neck (SCCHN). A single nucl ... Full text Open Access Link to item Cite

Differences in history of sexual behavior between patients with oropharyngeal squamous cell carcinoma and patients with squamous cell carcinoma at other head and neck sites.

Journal Article Head Neck · June 2011 BACKGROUND: An emerging epidemic of human papillomavirus (HPV)-associated oropharyngeal cancer has been proposed. The purpose of this study was for us to compare the sexual behaviors of patients with squamous cell carcinoma of the oropharynx (SCCOP) and pa ... Full text Link to item Cite

No evidence of an association of ERCC1 and ERCC2 polymorphisms with clinical outcomes of platinum-based chemotherapies in non-small cell lung cancer: a meta-analysis.

Journal Article Lung Cancer · June 2011 BACKGROUND: The nucleotide excision repair (NER) pathway modulates platinum-based chemotherapeutic efficacy by removing drug-induced DNA damage. METHODS: To summarize published data on the association between NER genes and responses to platinum-based chemo ... Full text Link to item Cite

The role of polymorphisms in circadian pathway genes in breast tumorigenesis.

Journal Article Breast Cancer Res Treat · June 2011 Disruption of the circadian rhythm or biological clock, which is regulated by a number of clock genes, including circadian locomotor output cycles kaput (CLOCK), period genes (PERs), and cryptochrome genes (CRYs), is a risk factor for breast cancer. We hyp ... Full text Link to item Cite

Association between a functional polymorphism (-1195T>C) in the IGFBP5 promoter and head and neck cancer risk.

Journal Article Head Neck · May 2011 BACKGROUND: To the best of our knowledge, no studies to date have evaluated roles of insulin-like growth factor binding protein 5 (IGFBP5) polymorphisms in risk of squamous cell carcinoma of the head and neck (SCCHN). METHODS: A hospital-based study of 108 ... Full text Link to item Cite

Association of ABCC2 polymorphisms with platinum-based chemotherapy response and severe toxicity in non-small cell lung cancer patients.

Journal Article Lung Cancer · May 2011 Platinum-based chemotherapy is the most common treatment for non-small cell lung cancer (NSCLC), and expression levels of drug metabolism and transport proteins are correlated with its efficacy and toxicity. In this study, we investigated the association o ... Full text Link to item Cite

Association of sequence variants on chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) with glioma susceptibility in a Chinese population.

Journal Article Am J Epidemiol · April 15, 2011 Two genome-wide association studies of glioma in European populations identified 14 genetic variants strongly associated with risk of glioma, but it is unknown whether these variants are associated with glioma risk in Asian populations. The authors genotyp ... Full text Link to item Cite

An analysis of single nucleotide polymorphisms of 125 DNA repair genes in the Texas genome-wide association study of lung cancer with a replication for the XRCC4 SNPs.

Journal Article DNA Repair (Amst) · April 3, 2011 DNA repair genes are important for maintaining genomic stability and limiting carcinogenesis. We analyzed all single nucleotide polymorphisms (SNPs) of 125 DNA repair genes covered by the Illumina HumanHap300 (v1.1) BeadChips in a previously conducted geno ... Full text Link to item Cite

Association of a novel functional promoter variant (rs2075533 C>T) in the apoptosis gene TNFSF8 with risk of lung cancer--a finding from Texas lung cancer genome-wide association study.

Journal Article Carcinogenesis · April 2011 Published genome-wide association studies (GWASs) have identified few variants in the known biological pathways involved in lung cancer etiology. To mine the possibly hidden causal single nucleotide polymorphisms (SNPs), we explored all SNPs in the extrins ... Full text Link to item Cite

A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers.

Journal Article Cancer Epidemiol Biomarkers Prev · April 2011 BACKGROUND: Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, ... Full text Link to item Cite

Association between p21 Ser31Arg polymorphism and cancer risk: a meta-analysis.

Journal Article Chin J Cancer · April 2011 P21 (CDKN1A), a key cell cycle regulatory protein that governs cell cycle progression from G1 to S phase, can regulate cell proliferation, growth arrest, and apoptosis. The Ser31Arg polymorphism is located in the highly conserved region of p21 and may enco ... Full text Open Access Link to item Cite

Genetic variants at the miR-124 binding site on the cytoskeleton-organizing IQGAP1 gene confer differential predisposition to breast cancer.

Journal Article Int J Oncol · April 2011 IQGAP1 knockout mice develop gastric cancer, but the IQGAP1 protein is associated with some advanced-stage human cancers. IQGAP1 expression is regulated by a microRNA, miR-124, through a binding site at the 3'-untranslated region, where a single nucleotide ... Full text Link to item Cite

A genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population.

Journal Article BMC Cancer · March 23, 2011 BACKGROUND: The human apurinic/apyrimidinic endonuclease 1/Redox effector factor-1 (APE1/Ref-1) is implicated in tumor development and progression. Recently, the APE1/Ref-1 promoter -141T/G variant (rs1760944) has been reported to be associated with lung c ... Full text Open Access Link to item Cite

ERCC1 and ERCC2 polymorphisms predict clinical outcomes of oxaliplatin-based chemotherapies in gastric and colorectal cancer: a systemic review and meta-analysis.

Journal Article Clin Cancer Res · March 15, 2011 PURPOSE: Nucleotide excision repair (NER) modulates platinum-based chemotherapeutic efficacy by removing drug-produced DNA damage. To summarize published data on the association between polymorphisms of NER genes (ERCC1 and ERCC2) and responses to oxalipla ... Full text Link to item Cite

p14ARF genetic polymorphisms and susceptibility to second primary malignancy in patients with index squamous cell carcinoma of the head and neck.

Journal Article Cancer · March 15, 2011 BACKGROUND: p14(ARF) , an alternate reading frame (ARF) product of the cyclin-dependent kinase inhibitor 2A locus, plays a critical role in crosstalk between the tumor protein 53 (p53) and retinoblastoma (Rb) pathways and in cellular anticancer mechanisms. ... Full text Link to item Cite

A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.

Journal Article PLoS Genet · March 2011 Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper ae ... Full text Open Access Link to item Cite

Clinical correlates of NRAS and BRAF mutations in primary human melanoma.

Journal Article Clin Cancer Res · January 15, 2011 PURPOSE: NRAS and BRAF mutations are common in cutaneous melanomas, although rarely detected mutually in the same tumor. Distinct clinical correlates of these mutations have not been described, despite in vitro data suggesting enhanced oncogenic effects. T ... Full text Link to item Cite

Polymorphisms in the SULF1 gene are associated with early age of onset and survival of ovarian cancer.

Journal Article J Exp Clin Cancer Res · January 7, 2011 BACKGROUND: SULF1 (sulfatase 1) selectively removes the 6-O-sulphate group from heparan sulfate, changing the binding sites for extracellular growth factors. SULF1 expression has been reported to be decreased in various cancers, including ovarian cancer. W ... Full text Open Access Link to item Cite

Polymorphisms of homologous recombination genes and clinical outcomes of non-small cell lung cancer patients treated with definitive radiotherapy.

Journal Article PLoS One · 2011 The repair of DNA double-strand breaks (DSBs) is the major mechanism to maintain genomic stability in response to irradiation. We hypothesized that genetic polymorphisms in DSB repair genes may affect clinical outcomes among non-small cell lung cancer (NSC ... Full text Open Access Link to item Cite

Shortened telomere length is associated with increased risk of cancer: a meta-analysis.

Journal Article PLoS One · 2011 BACKGROUND: Telomeres play a key role in the maintenance of chromosome integrity and stability, and telomere shortening is involved in initiation and progression of malignancies. A series of epidemiological studies have examined the association between sho ... Full text Open Access Link to item Cite

Promoter polymorphisms in matrix metallopeptidase 1 and risk of cutaneous melanoma.

Journal Article Eur J Cancer · January 2011 Matrix metallopeptidase 1 (MMP1) is one of the interstitial collagens in the extracellular matrix metalloproteinase family and involved in tumour behaviours. However, there is no report on the role of genetic variation in MMP1 in risk of cutaneous melanoma ... Full text Link to item Cite

Prospective analysis of DNA damage and repair markers of lung cancer risk from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial.

Journal Article Carcinogenesis · January 2011 Mutagen challenge and DNA repair assays have been used in case-control studies for nearly three decades to assess human cancer risk. The findings still engender controversy because blood was drawn after cancer diagnosis so the results may be biased, a type ... Full text Link to item Cite

A novel functional DEC1 promoter polymorphism -249T>C reduces risk of squamous cell carcinoma of the head and neck.

Journal Article Carcinogenesis · December 2010 Human DEC1 (deleted in esophageal cancer 1) gene is located on chromosome 9q, a region frequently deleted in various types of human cancers, including squamous cell carcinoma of the head and neck (SCCHN). However, only one epidemiological study has evaluat ... Full text Link to item Cite

Evidence that Gsta4 modifies susceptibility to skin tumor development in mice and humans.

Journal Article J Natl Cancer Inst · November 3, 2010 BACKGROUND: The incidence of nonmelanoma skin cancer (NMSC) is equivalent to that of all other cancers combined. Previously, we mapped the 12-O-tetradecanoylphorbol-13-acetate (TPA) skin tumor promotion susceptibility locus, Psl1, to distal chromosome 9 in ... Full text Link to item Cite

Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck.

Journal Article Carcinogenesis · November 2010 Single-nucleotide polymorphisms (SNPs) of TERT-rs2736098 (C > T) and CLPTM1L-rs401681(C > T) at the 5p15.33 locus are significantly associated with cancer risk as reported in genome-wide association studies (GWAS), but there are no reported studies for squ ... Full text Link to item Cite

Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck.

Journal Article Cancer · October 15, 2010 BACKGROUND: Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) may alter the processing, transcription, and expression of miRNAs and, thus, may contribute to cancer development. The authors hypothesized that common polymorphisms in pre-miRNAs are ... Full text Link to item Cite

No evidence of sex-related survival disparities among head and neck cancer patients receiving similar multidisciplinary care: a matched-pair analysis.

Journal Article Clin Cancer Res · October 15, 2010 PURPOSE: It is unknown whether there are survival disparities between men and women with squamous cell carcinoma of the head and neck (SCCHN), although some data suggest that men have worse outcomes. We conducted a matched-pair study that controlled for se ... Full text Link to item Cite

Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk.

Journal Article Carcinogenesis · October 2010 BACKGROUND: DNA strand breaks pose the greatest threat to genomic stability. Genetically determined mutagen sensitivity predisposes individuals to a variety of cancers, including glioma. However, polymorphisms in DNA strand break repair genes that may dete ... Full text Link to item Cite

The functional IGFBP7 promoter -418G>A polymorphism and risk of head and neck cancer.

Journal Article Mutat Res · September 30, 2010 Insulin-like growth factor binding protein 7 (IGFBP7) functions mostly independent of the IGF signaling pathway and acts as a tumor suppressor in multiple cancers, but roles of IGFBP7 genetic variants in cancer remains unknown. In a hospital-based study of ... Full text Link to item Cite

Human papillomavirus seropositivity synergizes with MDM2 variants to increase the risk of oral squamous cell carcinoma.

Journal Article Cancer Res · September 15, 2010 The increasing incidence of oral squamous cell carcinoma (OSCC) in young adults has been associated with sexually transmitted infections of human papillomavirus (HPV), particularly HPV16. Given the roles of p53 in tumor suppression and of HPV E6 and MDM2 o ... Full text Link to item Cite

Genotypes and haplotypes of the VEGF gene and survival in locally advanced non-small cell lung cancer patients treated with chemoradiotherapy.

Journal Article BMC Cancer · August 16, 2010 BACKGROUND: Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis involving in carcinogenesis, including lung cancer. We hypothesized that VEGF polymorphisms may affect survival outcomes among locally advanced non-small cell lung ca ... Full text Open Access Link to item Cite

A functional variant (-1304T>G) in the MKK4 promoter contributes to a decreased risk of lung cancer by increasing the promoter activity.

Journal Article Carcinogenesis · August 2010 Mitogen-activated protein kinase kinase 4 (MKK4) is a critical mediator of stress-activated protein kinase signals that regulate apoptosis, inflammations and tumorigenesis. Several polymorphisms have been identified in the MKK4 gene. We hypothesized that g ... Full text Link to item Cite

Body mass index and risk of head and neck cancer in a pooled analysis of case-control studies in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium.

Journal Article Int J Epidemiol · August 2010 BACKGROUND: Head and neck cancer (HNC) risk is elevated among lean people and reduced among overweight or obese people in some studies; however, it is unknown whether these associations differ for certain subgroups or are influenced by residual confounding ... Full text Link to item Cite

Messenger rna expression and methylation of candidate tumor-suppressor genes and risk of ovarian cancer-a case-control analysis

Journal Article International Journal of Molecular Epidemiology and Genetics · July 21, 2010 To investigate the association of expression and promoter methylation of tumor-suppressor genes with risk of ovarian cancer, we conducted a case-control study of 102 patients with serous epithelial ovarian cancer and 100 patients without ovarian cancers. W ... Cite

The launch of international journal of molecular epidemiology and genetics

Journal Article International Journal of Molecular Epidemiology and Genetics · July 21, 2010 Cite

A functional variant of tandem repeats in human telomerase gene was associated with survival of patients with early stages of non-small cell lung cancer.

Journal Article Clin Cancer Res · July 15, 2010 PURPOSE: Elevated levels of human telomerase (hTERT) mRNA in tumors is a marker for poorer survival in patients with stage I non-small cell lung cancer (NSCLC). A functional variant of MNS16A-short tandem repeats in hTERT (S allele) is associated with high ... Full text Link to item Cite

A variant in the CHEK2 promoter at a methylation site relieves transcriptional repression and confers reduced risk of lung cancer.

Journal Article Carcinogenesis · July 2010 Checkpoint kinase (CHEK) 2, a tumor suppressor gene, plays an essential role in the DNA damage checkpoint response cascade. We first investigated two polymorphisms in the proximal promoter of the CHEK2 gene and evaluated their associations with the risk of ... Full text Link to item Cite

The functional promoter polymorphism (-842G>C) in the PIN1 gene is associated with decreased risk of breast cancer in non-Hispanic white women 55 years and younger.

Journal Article Breast Cancer Res Treat · July 2010 PIN1, an isomerase that causes conformational changes in proteins, plays an important role in mammary epithelial cell growth both physiologically and pathologically. Thus, genetic variants in the PIN1 gene may alter protein function and cancer risk. We hav ... Full text Link to item Cite

A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck.

Journal Article Cancer · June 15, 2010 BACKGROUND: The authors conducted a hospital-based study of 1110 patients with squamous cell carcinoma of the head and neck (SCCHN) and a control group of 1129 patients to replicate the associations reported by a recent, large European study between 2 pote ... Full text Link to item Cite

Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: modeling odds ratios in pooled case-control data.

Journal Article Am J Epidemiol · June 15, 2010 Odds ratios for head and neck cancer increase with greater cigarette and alcohol use and lower body mass index (BMI; weight (kg)/height(2) (m(2))). Using data from the International Head and Neck Cancer Epidemiology Consortium, the authors conducted a form ... Full text Link to item Cite

FAS and FASLG genetic variants and risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck.

Journal Article Cancer Epidemiol Biomarkers Prev · June 2010 BACKGROUND: Single-nucleotide polymorphisms in the promoter region of the FAS and FASLG may alter the transcriptional activity of these genes. We therefore investigated the association between the FAS and FASLG polymorphisms and risk for second primary mal ... Full text Link to item Cite

Association of p53 codon 72 polymorphism with risk of second primary malignancy in patients with squamous cell carcinoma of the head and neck.

Journal Article Cancer · May 15, 2010 BACKGROUND: p53 plays a critical role in cellular anticancer mechanisms, and has been correlated with second primary malignancy (SPM) development. A common polymorphism in codon 72 of p53 results in an amino acid substitution and could influence p53 functi ... Full text Link to item Cite

Polymorphisms of the DNA repair gene MGMT and risk and progression of head and neck cancer.

Journal Article DNA Repair (Amst) · May 4, 2010 Methylating agents are involved in carcinogenesis, and the DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) removes methyl group from O(6)-methylguanine. Genetic variation in DNA repair genes has been shown to contribute to susceptibility ... Full text Link to item Cite

CASP8 polymorphisms contribute to cancer susceptibility: evidence from a meta-analysis of 23 publications with 55 individual studies.

Journal Article Carcinogenesis · May 2010 Several potentially functional polymorphisms of CASP8 encoding an apoptotic enzyme, caspase 8, have been implicated in cancer risk, but individually published studies showed inconclusive results. We performed a meta-analysis of 23 publications with a total ... Full text Link to item Cite

A novel XPF -357A>C polymorphism predicts risk and recurrence of bladder cancer.

Journal Article Oncogene · April 1, 2010 Xeroderma pigmentosum group F (XPF) has an essential role in the nucleotide excision repair pathway that removes a wide variety of DNA lesions. We hypothesized that genetic variants in XPF are associated with bladder cancer risk and recurrence. We selected ... Full text Link to item Cite

Association of TGF-beta1 genetic variants with HPV16-positive oropharyngeal cancer.

Journal Article Clin Cancer Res · March 1, 2010 PURPOSE: Transforming growth factor-beta1 (TGF-beta1) plays an important role in inflammation and immune responses, which control the human papillomavirus (HPV) clearance and escape of immune surveillance, and may contribute to genetic susceptibility to HP ... Full text Link to item Cite

Genetic polymorphisms of p21 and risk of second primary malignancy in patients with index squamous cell carcinoma of the head and neck.

Journal Article Carcinogenesis · February 2010 p21 plays an important role in modulating cell cycle control, inducing apoptosis, and inhibiting cell growth, subsequently affecting cancer risk. We investigated the association between two putatively functional single-nucleotide polymorphisms (SNPs) of p2 ... Full text Link to item Cite

The six-nucleotide deletion/insertion variant in the CASP8 promoter region is inversely associated with risk of squamous cell carcinoma of the head and neck.

Journal Article Cancer Prev Res (Phila) · February 2010 Caspase 8 (CASP8) is an apoptosis-related cysteine peptidase involved in the death receptor pathway and likely in the mitochondrial pathway. A CASP8 promoter region six-nucleotide deletion/insertion (-652 6N ins/del) variant and a coding region D302H polym ... Full text Link to item Cite

Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk.

Journal Article Int J Epidemiol · February 2010 BACKGROUND: Quitting tobacco or alcohol use has been reported to reduce the head and neck cancer risk in previous studies. However, it is unclear how many years must pass following cessation of these habits before the risk is reduced, and whether the risk ... Full text Link to item Cite

Definition of a functional single nucleotide polymorphism in the cell migration inhibitory gene MIIP that affects the risk of breast cancer.

Journal Article Cancer Res · February 1, 2010 The migration and invasion inhibitory protein MIIP is an inhibitor of cancer cell migration and invasion that inhibits breast tumorigenesis. In this case-control study, we evaluated the MIIP single nucleotide polymorphism (SNP) rs2295283 (codon 167, A>G, K ... Full text Link to item Cite

Reduced DNA repair capacity for removing tobacco carcinogen-induced DNA adducts contributes to risk of head and neck cancer but not tumor characteristics.

Journal Article Clin Cancer Res · January 15, 2010 PURPOSE: Although cigarette smoking and alcohol use are known risk factors for squamous cell carcinoma of head and neck (SCCHN), only a few exposed individuals develop this disease, suggesting an individual susceptibility. In this study, we investigated th ... Full text Link to item Cite

Genetic variants of p21 and p27 and pancreatic cancer risk in non-Hispanic Whites: a case-control study.

Journal Article Pancreas · January 2010 OBJECTIVES: p21 (WAF1/Cip1/CDKN1A) and p27 (Kip1/CDKN1B) are members of the Cip/Kip family of cyclin-dependent kinase inhibitors, which can induce cell cycle arrest and serve as tumor suppressors. We hypothesized that genetic variants in p21 and p27 may mo ... Full text Link to item Cite

Glutathione-S-transferase polymorphisms and complications of microvascular head and neck reconstruction.

Journal Article Arch Facial Plast Surg · 2010 BACKGROUND: Glutathione-S-transferase (GST) enzymes play a role in scavenging endogenous oxidants. Altered enzyme activity results from inherited polymorphisms, which results in increased oxidative stress. This study explores the role of GST polymorphisms ... Full text Link to item Cite

p73 G4C14-to-A4T14 polymorphism and risk of second primary malignancy after index squamous cell carcinoma of head and neck.

Journal Article Int J Cancer · December 1, 2009 P73 plays an important role in modulating cell-cycle control, inducing apoptosis, and inhibiting cell growth. A novel noncoding p73 G4C14-to-A4T14 exon 2 polymorphism was associated with risk of squamous cell carcinoma of the head and neck (SCCHN). We hypo ... Full text Link to item Cite

Polymorphisms in the survivin promoter are associated with age of onset of ovarian cancer

Journal Article International Journal of Clinical and Experimental Medicine · December 1, 2009 Survivin has been identified as an apoptosis inhibitor and a key regulator of mitosis. A common polymorphism (-31G>C) at the survivin promoter has been extensively studied in various cancers and reported to influence survivin expression. We hypothesize tha ... Cite

Genetic polymorphisms in the PTPN13 gene and risk of squamous cell carcinoma of head and neck.

Journal Article Carcinogenesis · December 2009 Fas-associated phosphatase-1 is encoded by the protein tyrosine phosphatase, non-receptor type 13 (PTPN13) gene and attributes to the resistance to Fas-mediated apoptosis in several tumors, including squamous cell carcinoma of the head and neck (SCCHN). Ho ... Full text Link to item Cite

The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer.

Journal Article BMC Gastroenterol · October 16, 2009 BACKGROUND: Both TGF-beta1 and VEGF play a critic role in the multiple-step process of tumorgenesis of gastric cancer. Single nucleotide polymorphisms (SNPs) of the TGFB1 and VEGF genes have been associated with risk and progression of many cancers. In thi ... Full text Open Access Link to item Cite

Total exposure and exposure rate effects for alcohol and smoking and risk of head and neck cancer: a pooled analysis of case-control studies.

Journal Article Am J Epidemiol · October 15, 2009 Although cigarette smoking and alcohol consumption increase risk for head and neck cancers, there have been few attempts to model risks quantitatively and to formally evaluate cancer site-specific risks. The authors pooled data from 15 case-control studies ... Full text Link to item Cite

A novel functional variant (-842G>C) in the PIN1 promoter contributes to decreased risk of squamous cell carcinoma of the head and neck by diminishing the promoter activity.

Journal Article Carcinogenesis · October 2009 PIN1, a new peptidyl-prolyl cis/trans isomerase, regulates the conformation of Pro-directed phosphorylation sites, revealing a new postphosphorylation regulatory mechanism. PIN1-induced conformational changes potentiate multiple oncogenic signaling pathway ... Full text Link to item Cite

An miR-502-binding site single-nucleotide polymorphism in the 3'-untranslated region of the SET8 gene is associated with early age of breast cancer onset.

Journal Article Clin Cancer Res · October 1, 2009 PURPOSE: MicroRNAs regulate gene expression by binding to the 3'-untranslated region (UTR) of target genes. Single-nucleotide polymorphisms of critical genes may affect their regulation by microRNAs. We have identified a single-nucleotide polymorphism with ... Full text Link to item Cite

Functional characterization of a promoter polymorphism in APE1/Ref-1 that contributes to reduced lung cancer susceptibility.

Journal Article FASEB J · October 2009 Apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1/Ref-1) is a ubiquitous multifunctional protein that possesses both DNA-repair and redox regulatory activities. Although it was originally identified as a DNA-repair enzyme, accumulating evi ... Full text Link to item Cite

Cancer of the Lung

Journal Article · September 1, 2009 This chapter provides an update on the epidemiology of lung cancer with an emphasis on the rapidly expanding literature exploring host susceptibility to tobacco carcinogenesis. It also reviews chemoprevention and lung screening trials. ... Full text Cite

Matched-pair analysis of race or ethnicity in outcomes of head and neck cancer patients receiving similar multidisciplinary care.

Journal Article Cancer Prev Res (Phila) · September 2009 It is unknown whether population-level racial or ethnic disparities in mortality from squamous cell carcinoma of the head and neck (SCCHN) also occur in the setting of standardized multidisciplinary-team directed care. Therefore, we conducted a matched-pai ... Full text Link to item Cite

Insulin-like growth factor-1 receptor-targeted therapy for non-small cell lung cancer: A mini review

Journal Article American Journal of Translational Research · August 4, 2009 Lung cancer leads all other cancers in both incidence and mortality. Recent advances in underlying molecular pathogenesis have validated a panel of protein tyrosine kinases as new targets in lung cancer treatment. Insulin-like growth factor-1 receptor (IGF ... Cite

Molecular epidemiology of genetic susceptibility to gastric cancer: Focus on single nucleotide polymorphisms in gastric carcinogenesis

Journal Article American Journal of Translational Research · August 3, 2009 Gastric cancer is a disease of gene-environment interactions, as suggested by the varying geographic patterns of its incidence. Even in areas with high rates of Helicobacter pylori infection, only a small proportion of infected individuals develop gastric ... Cite

Vitamin D receptor genetic polymorphisms and prostate cancer risk: A meta-analysis of 36 published studies

Journal Article International Journal of Clinical and Experimental Medicine · August 3, 2009 To update data on the role of vitamin D receptor (VDR) single nucleotide polymorphisms (SNPs) in susceptibility to prostate cancer, we performed a meta-analysis of 36 eligible publications on the association of TaqI, ApaI, BsmI, FokI and CDX2 SNPs of the V ... Cite

Single nucleotide polymorphism at rs1982073:T869C of the TGFbeta 1 gene is associated with the risk of radiation pneumonitis in patients with non-small-cell lung cancer treated with definitive radiotherapy.

Journal Article J Clin Oncol · July 10, 2009 PURPOSE: In search of reliable biologic markers to predict the risk of normal tissue damage by radio(chemo)therapy before treatment, we investigated the association between single nucleotide polymorphisms (SNPs) in the transforming growth factor 1 (TGFbeta ... Full text Link to item Cite

Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer.

Journal Article J Exp Clin Cancer Res · June 30, 2009 BACKGROUND: Some TGFB1 and VEGF polymorphisms are believed to be functional. Given that these genes are involved in tumor growth and progression including angiogenesis, dissemination, and invasiveness, we hypothesized that these polymorphisms would be asso ... Full text Open Access Link to item Cite

XRCC3 haplotypes and risk of gliomas in a Chinese population: a hospital-based case-control study.

Journal Article Int J Cancer · June 15, 2009 In mammalian cells, X-ray repair cross-complementing group3 (XRCC3) plays an important role in the DNA double-strand breaks (DSBs) repair by homologous recombination. Genetic polymorphisms in the XRCC3 gene may potentially affect the repair of DSBs and thu ... Full text Link to item Cite

Nucleotide excision repair core gene polymorphisms and risk of second primary malignancy in patients with index squamous cell carcinoma of the head and neck.

Journal Article Carcinogenesis · June 2009 The nucleotide excision repair (NER) pathway is central in response to damage induced by environmental carcinogens. Efficiency of this pathway, probably genetically determined, may modulate individual risk of developing squamous cell carcinoma of the head ... Full text Link to item Cite

Common genetic variants on 8q24 contribute to susceptibility to bladder cancer in a Chinese population.

Journal Article Carcinogenesis · June 2009 A recent genome-wide association study identified two common variants that confer susceptibility to bladder cancer. We hypothesized that these variants are associated with risk of bladder cancer in Chinese populations. We genotyped rs9642880 G>T on 8q24 an ... Full text Link to item Cite

GSTM1 and GSTT1 null polymorphisms and risk of salivary gland carcinoma

Journal Article International Journal of Clinical and Experimental Medicine · May 19, 2009 Glutathione S-transferase (GST) genes detoxify and metabolize carcinogens, including oxygen free radicals which may contribute to salivary gland carcinogenesis. This cancer center-based case-control association study included 166 patients with incident sal ... Cite

Genetic variants of the XRCC1 gene and susceptibility to esophageal cancer: A meta-analysis

Journal Article International Journal of Clinical and Experimental Medicine · May 18, 2009 To summarize published data on the role of common genetic variants of the X-ray repair cross-complementing group 1 (XRCC1) gene in susceptibility to esophageal cancer (EC), we performed a meta-analysis including 11 eligible publications with 3,306 patients ... Cite

Estimation of the effects of smoking and DNA repair capacity on coefficients of a carcinogenesis model for lung cancer.

Journal Article Int J Cancer · May 1, 2009 Numerous prospective and retrospective studies have clearly demonstrated a dose-related increased lung cancer risk associated with cigarette smoking, with evidence also for a genetic component to risk. In this study, using the two-stage clonal expansion st ... Full text Link to item Cite

Glutathione S-transferase polymorphisms and risk of second primary malignancy after index squamous cell carcinoma of the head and neck.

Journal Article Cancer Prev Res (Phila) · May 2009 Glutathione S-transferases (GST) detoxify carcinogens in tobacco smoke, which plays a major role in development of not only squamous cell carcinoma of the head and neck (SCCHN) but also second primary malignancy (SPM) after index SCCHN. We hypothesized tha ... Full text Link to item Cite

Marijuana smoking and the risk of head and neck cancer: pooled analysis in the INHANCE consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2009 BACKGROUND: Marijuana contains carcinogens similar to tobacco smoke and has been suggested by relatively small studies to increase the risk of head and neck cancer (HNC). Because tobacco is a major risk factor for HNC, large studies with substantial number ... Full text Link to item Cite

Putative functional polymorphisms of MMP9 predict survival of NSCLC in a Chinese population.

Journal Article Int J Cancer · May 1, 2009 Matrix metalloproteinases (MMPs) play a crucial role in cancer progression and their over-expression is often associated with unfavorable survival of non-small cell lung cancer (NSCLC). Because genetic variants can alter expression level or biological acti ... Full text Link to item Cite

Association of p73 G4C14-to-A4T14 polymorphism with human papillomavirus type 16 status in squamous cell carcinoma of the head and neck in non-Hispanic whites.

Journal Article Cancer · April 15, 2009 BACKGROUND: The tumor protein p73 interacts with the human papillomavirus type 16 (HPV-16) oncoproteins E6 and E7, and p73 variation may modify the interaction between p73 protein and HPV-16 oncogenic proteins and contribute to cellular malignant transform ... Full text Link to item Cite

Association between polymorphisms in the GSTA4 gene and risk of lung cancer: a case-control study in a Southeastern Chinese population.

Journal Article Mol Carcinog · March 2009 GST Alpha 4 (GSTA4) has an important role in the protection against oxidative stress induced by carcinogens such as tobacco smoke. However, few studies investigated the association between GSTA4 polymorphisms and lung cancer risk. We genotyped three select ... Full text Link to item Cite

Association of genetic polymorphisms of ER-alpha and the estradiol-synthesizing enzyme genes CYP17 and CYP19 with breast cancer risk in Chinese women.

Journal Article Breast Cancer Res Treat · March 2009 Estrogen plays a role in breast cancer development, and genetic polymorphisms in estrogen receptor gene ER-alpha and genes regulating estrogen biosynthesis and metabolisms are associated with the risk of breast cancer in women in western countries. Therefo ... Full text Link to item Cite

DNA repair phenotype and cancer susceptibility--a mini review.

Journal Article Int J Cancer · March 1, 2009 DNA repair is a complicated biological process, consisting of several distinct pathways, that plays a fundamental role in the maintenance of genomic integrity. The very important field of DNA repair and cancer risk has developed rapidly in the past decades ... Full text Link to item Cite

Serial dilution curve: a new method for analysis of reverse phase protein array data.

Journal Article Bioinformatics · March 1, 2009 UNLABELLED: Reverse phase protein arrays (RPPAs) are a powerful high-throughput tool for measuring protein concentrations in a large number of samples. In RPPA technology, the original samples are often diluted successively multiple times, forming dilution ... Full text Open Access Link to item Cite

Association of XRCC1 polymorphisms and risk of differentiated thyroid carcinoma: a case-control analysis.

Journal Article Thyroid · February 2009 BACKGROUND: Numerous single-nucleotide polymorphisms (SNPs) of the DNA repair gene XRCC1 have been described. These SNPs have been increasingly studied in the epidemiology of various cancer types. In this study we evaluated the risk association between six ... Full text Link to item Cite

Genetic variants in GTF2H1 and risk of lung cancer: a case-control analysis in a Chinese population.

Journal Article Lung Cancer · February 2009 GTF2H1, the p62 subunit of the multiprotein complex transcription factor IIH (TFIIH), participates in both the nucleotide excision repair process and transcription control by specifically interacting with a variety of factors important in carcinogenesis. T ... Full text Link to item Cite

Genetic susceptibility of lung cancer associated with common variants in the 3' untranslated regions of the adenosine triphosphate-binding cassette B1 (ABCB1) and ABCC1 candidate transporter genes for carcinogen export.

Journal Article Cancer · February 1, 2009 BACKGROUND: Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NKK) is a well defined carcinogen that can induce lung cancer. Genetic polymorphisms in its disposition pathways could modify the risk of developing lung cancer. The a ... Full text Link to item Cite

Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · February 2009 BACKGROUND: The magnitude of risk conferred by the interaction between tobacco and alcohol use on the risk of head and neck cancers is not clear because studies have used various methods to quantify the excess head and neck cancer burden. METHODS: We analy ... Full text Link to item Cite

Trends in head and neck cancer incidence in Tianjin, China, between 1981 and 2002.

Journal Article Head Neck · February 2009 BACKGROUND: Head and neck cancer is 1 of the major global health issues but received limited attention, and its incidence has rarely been systematically studied in China. METHODS: The population-based cancer registry of the urban Tianjin was used to examin ... Full text Link to item Cite

Family history of cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.

Journal Article Int J Cancer · January 15, 2009 Alcohol and tobacco consumption are well-recognized risk factors for head and neck cancer (HNC). Evidence suggests that genetic predisposition may also play a role. Only a few epidemiologic studies, however, have considered the relation between HNC risk an ... Full text Link to item Cite

Type of alcoholic beverage and risk of head and neck cancer--a pooled analysis within the INHANCE Consortium.

Journal Article Am J Epidemiol · January 15, 2009 The authors pooled data from 15 case-control studies of head and neck cancer (9,107 cases, 14,219 controls) to investigate the independent associations with consumption of beer, wine, and liquor. In particular, they calculated associations with different m ... Full text Link to item Cite

ERCC6/CSB gene polymorphisms and lung cancer risk.

Journal Article Cancer Lett · January 8, 2009 Nucleotide excision repair (NER) enzymes are critical for the removal of bulky DNA adducts caused by environmental carcinogens such as smoking. Of them, Cockayne syndrome complementation group B (CSB), coded by ERCC6, recruits NER repair factors to the DNA ... Full text Link to item Cite

Association and interactions between DNA repair gene polymorphisms and adult glioma.

Journal Article Cancer Epidemiol Biomarkers Prev · January 2009 It is generally accepted that glioma develops through accumulation of genetic alterations. We hypothesized that polymorphisms of candidate genes involved in the DNA repair pathways may contribute to susceptibility to glioma. To address this possibility, we ... Full text Link to item Cite

Association between two functional polymorphisms of insulin-like growth factor binding protein 3 and colorectal cancer risk in a Chinese population.

Journal Article J Toxicol Environ Health A · 2009 Circulating levels of insulin-like growth factor binding protein 3 (IGFBP3) are modulated by functional variants of IGFBP3 and therefore may be associated with higher risk of colorectal cancer development. However, few studies have investigated the role of ... Full text Link to item Cite

Association of human aryl hydrocarbon receptor gene polymorphisms with risk of lung cancer among cigarette smokers in a Chinese population.

Journal Article Pharmacogenet Genomics · January 2009 BACKGROUND AND OBJECTIVE: Most of the carcinogenic effects of polycyclic aromatic hydrocarbons present in tobacco smoke are mediated by the aryl hydrocarbon receptor (AHR), a ligand-dependent transcription factor that regulates tobacco-induced expression o ... Full text Link to item Cite

Interactions of IL-12A and IL-12B polymorphisms on the risk of cervical cancer in Chinese women.

Journal Article Clin Cancer Res · January 1, 2009 PURPOSE: Accumulative evidence suggests that interleukin-12 (IL-12) plays a central role in the Th1 responses and thus participates in the carcinogenesis of human papillomavirus-related cervical cancer. We hypothesized that potentially functional polymorph ... Full text Link to item Cite

p73 G4C14-to-A4T14 polymorphism and risk of human papillomavirus-associated squamous cell carcinoma of the oropharynx in never smokers and never drinkers.

Journal Article Cancer · December 15, 2008 BACKGROUND: The p53 tumor suppressor protein homolog p73 can be inactivated by oncoprotein E6 of human papillomavirus (HPV). Variation in p73 may alter the interaction between the E6 protein and p73 and, thus, alter the risk for HPV-associated carcinogenes ... Full text Link to item Cite

Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma.

Journal Article Hum Mutat · December 2008 Caspase-8 (CASP8) and caspase-10 (CASP10) play key roles in regulating apoptosis, and their functional polymorphisms may alter apoptosis and cancer risk. However, no reported studies have investigated the association between such polymorphisms and the risk ... Full text Link to item Cite

Smoking-related genomic signatures in non-small cell lung cancer.

Journal Article Am J Respir Crit Care Med · December 1, 2008 RATIONALE: Tobacco smoking is responsible for 85% of all lung cancers. To further our understanding of the molecular pathogenesis of lung cancer, we determined whether smoking history leads to the emergence of specific genomic alterations found in non-smal ... Full text Link to item Cite

Tagging single nucleotide polymorphisms in MBD4 are associated with risk of lung cancer in a Chinese population.

Journal Article Lung Cancer · December 2008 MBD4 (methyl-CpG binding domain protein 4) was identified as a methyl-CpG binding protein and plays an important role in DNA methylation and carcinogenesis. We hypothesized that genetic variants in MBD4 were associated with lung cancer risk. We selected an ... Full text Link to item Cite

Combined effects of the p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms on the risk of HPV16-associated oral cancer in never-smokers.

Journal Article Carcinogenesis · November 2008 Because p53 and p73 are associated with critical cellular processes and can be inactivated or degraded by the human papillomavirus (HPV) E6 oncoprotein, we investigated the combined effects of p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms on the risk o ... Full text Link to item Cite

Reply

Journal Article Plastic and Reconstructive Surgery · November 1, 2008 Full text Cite

CASP3 polymorphisms and risk of squamous cell carcinoma of the head and neck.

Journal Article Clin Cancer Res · October 1, 2008 PURPOSE: Caspase-3 plays a central role in executing cell apoptosis and thus in carcinogenesis, but little is known about the role of CASP3 variants in susceptibility to SCCHN. EXPERIMENTAL DESIGN: Genotype and haplotypes of the first intron (rs4647601:G>T ... Full text Link to item Cite

Polymorphisms of the DNMT3B gene and risk of squamous cell carcinoma of the head and neck: a case-control study.

Journal Article Cancer Lett · September 8, 2008 DNA-methyltransferase-3B (DNMT3B) may play an oncogenic role during tumorigenesis, and its genetic variants have been reportedly to be associated with risk of several cancers, but few studies have investigated their roles in squamous cell carcinoma of the ... Full text Link to item Cite

An expanded risk prediction model for lung cancer.

Journal Article Cancer Prev Res (Phila) · September 2008 Risk prediction models are useful in clinical decision making. We have published an internally validated prediction tool for lung cancer based on easily obtainable epidemiologic and clinical data. Because the precision of the model was modest, we now estim ... Full text Link to item Cite

Methyl-CpG binding domain 1 gene polymorphisms and lung cancer risk in a Chinese population.

Journal Article Biomarkers · September 2008 Polymorphisms of the methyl-CpG binding domain 1 (MBD1) gene may influence MBD1 activity on gene expression profiles, thereby modulating individual susceptibility to lung cancer. To test this hypothesis, we investigated the associations of four MBD1 polymo ... Full text Link to item Cite

Genotypes and haplotypes of ERCC1 and ERCC2/XPD genes predict levels of benzo[a]pyrene diol epoxide-induced DNA adducts in cultured primary lymphocytes from healthy individuals: a genotype-phenotype correlation analysis.

Journal Article Carcinogenesis · August 2008 Benzo[a]pyrene diol epoxide (BPDE)-induced DNA adducts are a risk factor for tobacco-related cancers. Excision repair cross-complementing complementation group 1 (ERCC1) and excision repair cross-complementing complementation group 2/xeroderma pigmentosum ... Full text Link to item Cite

Involuntary smoking and head and neck cancer risk: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.

Journal Article Cancer Epidemiol Biomarkers Prev · August 2008 Although active tobacco smoking has been identified as a major risk factor for head and neck cancer, involuntary smoking has not been adequately evaluated because of the relatively low statistical power in previous studies. We took advantage of data pooled ... Full text Link to item Cite

Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx.

Journal Article Clin Cancer Res · July 1, 2008 PURPOSE: Human DNA glycosylases NEIL1 and NEIL2 participate in oxidized base excision repair and protect cells from DNA damage. NEIL1 (MIM:608844) and NEIL2 (MIM:608933) variants may affect their protein functions, leading to altered cell death and carcino ... Full text Link to item Cite

Association of polymorphisms in one-carbon metabolizing genes and lung cancer risk: a case-control study in Chinese population.

Journal Article Lung Cancer · July 2008 One-carbon metabolism facilitates the cross-talk between genetic and epigenetic processes, making it a good candidate for studying the risk of lung cancer. To investigate the role of common variants of one-carbon metabolizing genes on lung cancer risk, tot ... Full text Link to item Cite

Genetic variants in the H2AFX promoter region are associated with risk of sporadic breast cancer in non-Hispanic white women aged

Journal Article Breast Cancer Res Treat · July 2008 The histone protein family member X (H2AFX) is important in maintaining chromatin structure and genetic stability. Genetic variants in H2AFX may alter protein functions and thus cancer risk. In this case-control study, we genotyped four common single nucle ... Full text Link to item Cite

Polymorphisms in microRNA targets: a gold mine for molecular epidemiology.

Journal Article Carcinogenesis · July 2008 MicroRNAs are non-coding small RNAs that regulate gene expression by Watson-Crick base pairing to target messenger RNA (mRNA). They are involved in most biological and pathological processes, including tumorigenesis. The binding of microRNA to mRNA is crit ... Full text Link to item Cite

The hOGG1 Ser326Cys polymorphism and lung cancer risk: a meta-analysis.

Journal Article Cancer Epidemiol Biomarkers Prev · July 2008 The potentially functional polymorphism Ser326Cys in the human 8-oxoguanine DNA glycosylase (hOGG1) gene has been implicated in lung cancer risk, but published studies have mixed findings. To summarize published data, we did a comprehensive meta-analysis. ... Full text Link to item Cite

A cancer incidence survey in Tianjin: the third largest city in China-between 1981 and 2000.

Journal Article Cancer Causes Control · June 2008 During the past three decades, the social/natural environment and lifestyle of people in China have undergone a marked transformation to westernization. However, age-standardized cancer rates have not been determined to any great extent in China. In this s ... Full text Link to item Cite

A novel functional polymorphism C1797G in the MDM2 promoter is associated with risk of bladder cancer in a Chinese population.

Journal Article Clin Cancer Res · June 1, 2008 PURPOSE: MDM2 is believed to regulate the p53 level in modulating DNA repair, cell cycle control, cell growth, and apoptosis. We hypothesize that genetic variants in the MDM2 gene are associated with risk of bladder cancer. EXPERIMENTAL DESIGN: We first co ... Full text Link to item Cite

Chromosome instability and risk of squamous cell carcinomas of head and neck.

Journal Article Cancer Res · June 1, 2008 In 895 subjects with squamous cell carcinoma of the head and neck (SCCHN) and 898 cancer-free controls matched by age, sex, and ethnicity, we validated our previous finding that mutagen sensitivity as measured by the frequency of chromatid breaks in vitro ... Full text Link to item Cite

DNA repair capacity and lung cancer risk in never smokers.

Journal Article Cancer Epidemiol Biomarkers Prev · June 2008 Besides secondhand smoke exposure, few other risk factors for lung cancer in lifetime never smokers have been identified. We present the estimates of lung cancer risk associated with suboptimal DNA repair capacity (DRC) measured by the host-cell reactivati ... Full text Link to item Cite

Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review.

Journal Article Genet Med · June 2008 The association of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers was assessed through a meta-analysis of published case-control studies and a pooled analysis of both published and unpublished case-control studies from the Genetic Susceptib ... Full text Link to item Cite

Polymorphisms in excision repair cross-complementing group 4 (ERCC4) and susceptibility to primary lung cancer in a Chinese Han population.

Journal Article Lung Cancer · June 2008 ERCC4/XPF protein plays an important role in the nucleotide excision repair (NER) pathway, and deficiencies in the gene encoding it can lead to a repair-deficiency syndrome, xeroderma pigmentosum group F (XP-F). Common variants on this gene are assumed to ... Full text Link to item Cite

Potentially functional polymorphisms of EXO1 and risk of lung cancer in a Chinese population: A case-control analysis.

Journal Article Lung Cancer · June 2008 Exonuclease 1 (EXO1) is an important nucleases involved in mismatch repair system that contributes to maintain genomic stability, to modulate DNA recombination, and to mediate cell cycle arrest. Potentially functional polymorphisms in EXO1 may alter cancer ... Full text Link to item Cite

Haplotype and genotypes of the VDR gene and cutaneous melanoma risk in non-Hispanic whites in Texas: a case-control study.

Journal Article Int J Cancer · May 1, 2008 In a hospital-based case-control study of 805 non-Hispanic whites with cutaneous melanoma and 841 cancer-free age-, sex- and ethnicity-matched control subjects, 3 VDR polymorphisms (i.e., TaqI, BsmI and FokI) were genotyped using blood samples collected be ... Full text Link to item Cite

Dietary magnesium and DNA repair capacity as risk factors for lung cancer.

Journal Article Carcinogenesis · May 2008 Magnesium (Mg) is required for maintenance of genomic stability; however, data on the relationship between dietary Mg intake and lung cancer are lacking. In an ongoing lung cancer case-control study, we identified 1139 cases and 1210 matched healthy contro ... Full text Link to item Cite

Tagging single nucleotide polymorphisms in phosphoinositide-3-kinase-related protein kinase genes involved in DNA damage "checkpoints" and lung cancer susceptibility.

Journal Article Clin Cancer Res · May 1, 2008 PURPOSE: DNA damage checkpoints are initiated by its sensor proteins of the phosphoinositide-3-kinase-related protein kinase family, including ataxia-telangiectasia mutated, ataxia-telangiectasia and Rad3-related, and DNA-dependent protein kinase catalytic ... Full text Link to item Cite

Association of the variable number of tandem repeats polymorphism in the promoter region of the SMYD3 gene with risk of esophageal squamous cell carcinoma in relation to tobacco smoking.

Journal Article Cancer Sci · April 2008 The etiology of esophageal squamous cell carcinoma (ESCC) has been shown to be multifactorial, including genetic, epigenetic, and environmental factors, such as tobacco smoking. A variable number of tandem repeats (VNTR) polymorphism in the promoter region ... Full text Link to item Cite

p53 codon 72 polymorphism associated with risk of human papillomavirus-associated squamous cell carcinoma of the oropharynx in never-smokers.

Journal Article Carcinogenesis · April 2008 The tumor suppressor p53 protein can be bound, degraded and inactivated by the human papillomavirus (HPV) E6 oncoprotein. The p53 protein's susceptibility to this oncoprotein may be influenced by the p53 codon 72 polymorphism, but the role of such a polymo ... Full text Link to item Cite

Fas single nucleotide polymorphisms and risk of thyroid and salivary gland carcinomas: a case-control analysis.

Journal Article Head Neck · March 2008 BACKGROUND: The purpose of this study was to examine the association between 4 Fas single nucleotide polymorphisms (SNPs) and risk of differentiated thyroid carcinoma (DTC) and salivary gland carcinoma (SGC). METHODS: We conducted a case-control study incl ... Full text Link to item Cite

Polymorphisms of LIG4 and XRCC4 involved in the NHEJ pathway interact to modify risk of glioma.

Journal Article Hum Mutat · March 2008 Although the role of environmental risk factors in the etiology of gliomas remains to be elucidated, accumulative epidemiological evidence suggests that genetic factors, such as variants in genes involved in DNA repair, may also play an important role. LIG ... Full text Link to item Cite

Genetic variants in peroxisome proliferator-activated receptor-gamma gene are associated with risk of lung cancer in a Chinese population.

Journal Article Carcinogenesis · February 2008 Accumulating evidence indicates that activation of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) dampens the inflammation cascade and inhibits tumor growth of the lung, suggesting that it has tumor suppressor functions. We performed a c ... Full text Link to item Cite

Polymorphisms in hMLH1 and risk of early-onset lung cancer in a southeast Chinese population.

Journal Article Lung Cancer · February 2008 DNA mismatch repair (MMR) plays an important role in maintaining genome stability. Defects in MMR genes have been involved in several types of sporadic and hereditary cancers. hMLH1 is considered one of central members of the MMR pathway. We conducted a ho ... Full text Link to item Cite

Serum cotinine concentration and wound complications in head and neck reconstruction.

Journal Article Plast Reconstr Surg · February 2008 BACKGROUND: The authors examined whether the preoperative serum concentrations of cotinine accurately predict the risk of complications in patients undergoing flap reconstruction of head and neck cancer defects. METHODS: Patients with incident stage III or ... Full text Link to item Cite

Genetic variation in heat shock protein 60 gene and coronary heart disease in China: tagging-SNP haplotype analysis in a case-control study.

Journal Article Cell Stress Chaperones · 2008 BACKGROUND: High levels of circulating heat shock protein 60 (Hsp60) and antibody to human Hsp60 have been associated with greater risk of coronary heart disease (CHD) in several studies, but associations between polymorphisms of the hsp60 gene and CHD ris ... Full text Link to item Cite

Squamous cell carcinoma of the head and neck in never smoker-never drinkers: a descriptive epidemiologic study.

Journal Article Head Neck · January 2008 BACKGROUND: While the attributed risk factors for the vast majority of patients with squamous cell carcinoma of the head and neck (SCCHN) are smoking and alcohol abuse, there appears to be a rising proportion of SCCHN patients who report no significant smo ... Full text Link to item Cite

In vitro benzo[a]pyrene diol epoxide-induced DNA damage and chromosomal aberrations in primary lymphocytes, smoking, and risk of squamous cell carcinoma of the head and neck.

Journal Article Int J Cancer · December 15, 2007 Cigarette smoking is a major risk factor for squamous cell carcinoma of the head and neck (SCCHN), but only a fraction of those exposed to cigarette smoke develops SCCHN, suggesting variation in individual susceptibility. Tobacco smoke contains a number of ... Full text Link to item Cite

Association between delta-aminolevulinic acid dehydratase (ALAD) polymorphism and blood lead levels: a meta-regression analysis.

Journal Article J Toxicol Environ Health A · December 2007 A meta-regression analysis was undertaken to evaluate the association between delta-aminolevulinic acid dehydratase (ALAD) genotypes and blood lead levels obtained from data published in various journals. In total, 15 studies were included in the final ana ... Full text Link to item Cite

Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients.

Journal Article J Pediatr Hematol Oncol · December 2007 Defective apoptosis signaling by the Fas pathway has carcinogenic implications. We analyzed 123 pediatric patients with osteosarcoma for Fas single nucleotide polymorphisms: 2 of the promoter region (-1377 G>A and -670 A>G) and 2 of the coding region (exon ... Full text Link to item Cite

HLA-DM polymorphism and risk of trichloroethylene induced medicamentosa-like dermatitis.

Journal Article Biomed Environ Sci · December 2007 OBJECTIVE: To establish the association between genetic polymorphisms of HLA-DMA and HLA-DMB and risk of developing trichloroethylene-induced medicamentosa-like dermatitis (TIMLD). METHODS: Sixty-one cases were medically confirmed to have been affected wit ... Link to item Cite

Joint effects of dietary trace metals and DNA repair capacity in lung cancer risk.

Journal Article Cancer Epidemiol Biomarkers Prev · December 2007 In a large case-control study, we previously reported that dietary intakes of zinc (Zn) and copper (Cu), but not selenium (Se), were inversely associated with lung cancer risk. Because Zn, Cu, Se, iron (Fe), and calcium (Ca) are important for maintaining D ... Full text Link to item Cite

Association between plasma BPDE-Alb adduct concentrations and DNA damage of peripheral blood lymphocytes among coke oven workers.

Journal Article Occup Environ Med · November 2007 OBJECTIVES: Coke oven emissions (COE) containing polycyclic aromatic hydrocarbons (PAHs) can induce both benzo[a]pyrene-r-7, t-8, t-9,c-10-tetrahydotetrol-albumin (BPDE-Alb) adducts and DNA damage. However, the relation between these biomarkers for early b ... Full text Link to item Cite

Overexpression of annexin a1 induced by terephthalic acid calculi in rat bladder cancer.

Journal Article Proteomics · November 2007 Prolonged cell proliferation in response to irritation by bladder calculi can evoke malignant transformation of the urothelium. However, the molecular mechanisms responsible for calculi-associated bladder carcinogenesis are unknown. We compared the protein ... Full text Link to item Cite

Polymorphisms of CAK genes and risk for lung cancer: a case-control study in Chinese population.

Journal Article Lung Cancer · November 2007 The incidence of lung cancer has been increasing over recent decades. Previous studies show that polymorphisms of the genes involved in carcinogen-detoxication, DNA repair and cell cycle control compose of the risk factors for lung cancer. Recent observati ... Full text Link to item Cite

Repair capacity for UV light induced DNA damage associated with risk of nonmelanoma skin cancer and tumor progression.

Journal Article Clin Cancer Res · November 1, 2007 PURPOSE: To examine the role of suboptimal DNA repair capacity (DRC) for UV light-induced DNA damage in the development of nonmelanoma skin cancer (NMSC) and tumor progression. EXPERIMENTAL DESIGN: We conducted a hospital-based case-control study of 255 pa ... Full text Link to item Cite

Single-nucleotide polymorphisms at the TP53-binding or responsive promoter regions of BAX and BCL2 genes and risk of squamous cell carcinoma of the head and neck.

Journal Article Carcinogenesis · September 2007 Tumor protein 53 (TP53), a transcriptional factor, induces expression of the B-cell lymphoma 2-associated X protein (BAX) gene by directly binding to the TP53-binding element in the BAX promoter but inhibits B-cell lymphoma 2 (BCL2) promoter-driven transcr ... Full text Link to item Cite

Tagging SNPs in non-homologous end-joining pathway genes and risk of glioma.

Journal Article Carcinogenesis · September 2007 Ionizing radiation is known to cause DNA damage, including single-strand and double-strand DNA breaks (DSBs), and the unrepair of DNA damage, particularly DSBs, may cause chromosome aberrations. Although the etiology of gliomas remains unclear, exposure to ... Full text Link to item Cite

Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck.

Journal Article Cancer · August 15, 2007 BACKGROUND: Tobacco smoke contains numerous carcinogens that cause DNA damage, including oxidative lesions that are removed effectively by the base-excision repair (BER) pathway, in which adenosine diphosphate ribosyl transferase (ADPRT), x-ray repair cros ... Full text Link to item Cite

Potentially functional single nucleotide polymorphisms in the core nucleotide excision repair genes and risk of squamous cell carcinoma of the head and neck.

Journal Article Cancer Epidemiol Biomarkers Prev · August 2007 Susceptibility to cancer has been associated with DNA repair capacity, a global reflection of all functional variants, most of which are relatively rare. Among the 1,098 single nucleotide polymorphisms (SNP) identified in the eight core nucleotide excision ... Full text Link to item Cite

[Estimation of gene-environment interaction regarding partial case-control study with missing data on gene information of the controls].

Journal Article Zhonghua Liu Xing Bing Xue Za Zhi · August 2007 OBJECTIVE: To discuss the estimation on gene-environment interaction in partial case-control studies when gene information of the controls was partly missing. METHODS: The results of hot deck multiple imputation and listwise deletion analysis were compared ... Link to item Cite

Polymorphisms of cytosolic serine hydroxymethyltransferase and risk of lung cancer: a case-control analysis.

Journal Article Lung Cancer · August 2007 Suboptimal DNA repair capacity is a risk factor for cancer that may be modulated by dietary nutrient intake, and serine hydroxymethyltransferase (SHMT) participates in folate metabolism and synthesis of purines and pyrimidines needed for DNA repair. Theref ... Full text Link to item Cite

Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck.

Journal Article Clin Cancer Res · July 15, 2007 PURPOSE: Tumor protein 53-binding protein 1 (TP53BP1) and TP53 interact during TP53-mediated transcriptional activation and during checkpoint activation in response to DNA damage. Because suboptimal repair of tobacco-induced DNA damage is associated with r ... Full text Link to item Cite

X-ray repair cross-complementing group 1 (XRCC1) single-nucleotide polymorphisms and the risk of salivary gland carcinomas.

Journal Article Cancer · July 15, 2007 BACKGROUND: X-ray repair cross complementing group 1 (XRCC1) is important in the repair of single-strand DNA breaks caused by endogenous oxidative species and exogenous carcinogens. METHODS: This tertiary cancer center-based, case-control association study ... Full text Link to item Cite

A modified host-cell reactivation assay to measure repair of alkylating DNA damage for assessing risk of lung adenocarcinoma.

Journal Article Carcinogenesis · July 2007 The nicotine-derived nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces lung adenocarcinoma through formation of DNA adducts. Our previous research on susceptibility to tobacco-induced carcinogenesis focused on benzo[a]pyrene diol epo ... Full text Link to item Cite

Epidemiology of carcinogen metabolism genes and risk of squamous cell carcinoma of the head and neck.

Journal Article Head Neck · July 2007 The risk association between tobacco and alcohol use with squamous cell carcinoma of the head and neck (SCCHN) is well recognized. However, clearly not all individuals who smoke or drink develop SCCHN. Individual genetic susceptibility differences in carci ... Full text Link to item Cite

In vitro benzo[a]pyrene diol epoxide-induced DNA adducts and risk of squamous cell carcinoma of head and neck.

Journal Article Cancer Res · June 15, 2007 In this large confirmatory study of 803 patients with squamous cell carcinoma of head and neck (SCCHN) and 839 controls frequency matched by age, sex, and ethnicity, we further examined potential predictors of benzo[a]pyrene diol epoxide (BPDE)-induced add ... Full text Link to item Cite

Functional polymorphisms of JWA gene are associated with risk of bladder cancer.

Journal Article J Toxicol Environ Health A · June 2007 The JWA gene is a novel cell differentiation-related gene thought to be a responsive gene in response to DNA damage and repair induced by environmental stressors. Recently, a novel single nucleotide polymorphism (SNP) was identified in the promoter of the ... Full text Link to item Cite

Identification of JWA as a novel functional gene responsive to environmental oxidative stress induced by benzo[a]pyrene and hydrogen peroxide.

Journal Article Free Radic Biol Med · June 1, 2007 Oxidative stress has been implicated as one of the primary mechanisms inducing DNA damage and believed to mediate aging and progression of numerous age-related diseases, including cancer. JWA, a gene previously described to mediate differentiation of leuke ... Full text Link to item Cite

Identification and functional characterization of JWA polymorphisms and their association with risk of gastric cancer and esophageal squamous cell carcinoma in a Chinese population.

Journal Article J Toxicol Environ Health A · June 2007 Recently, a novel single nucleotide polymorphism (SNP) in the promoter of the JWA gene (-76G --> C) was identified that may alter the transcription activity and thus play a role in increased risk of bladder cancer. In this study, a screen for more novel va ... Full text Link to item Cite

Tagging single nucleotide polymorphisms in excision repair cross-complementing group 1 (ERCC1) and risk of primary lung cancer in a Chinese population.

Journal Article Pharmacogenet Genomics · June 2007 BACKGROUND AND OBJECTIVE: Low nucleotide excision repair (NER) capacity has been associated with increased risk of lung cancer. Excision repair cross-complementing group 1 (ERCC1) is one of the NER core enzymes, and polymorphisms in ERCC1 may lead to alter ... Full text Link to item Cite

Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.

Journal Article J Natl Cancer Inst · May 16, 2007 BACKGROUND: At least 75% of head and neck cancers are attributable to a combination of cigarette smoking and alcohol drinking. A precise understanding of the independent association of each of these factors in the absence of the other with the risk of head ... Full text Link to item Cite

Sequence variations in DNA repair gene XPC is associated with lung cancer risk in a Chinese population: a case-control study.

Journal Article BMC Cancer · May 13, 2007 BACKGROUND: The nucleotide excision repair (NER) protein, xeroderma pigmentosum C (XPC), participates in recognizing DNA lesions and initiating DNA repair in response to DNA damage. Because mutations in XPC cause a high risk of cancer in XP patients, we hy ... Full text Open Access Link to item Cite

172G>T variant in the 5' untranslated region of DNA repair gene RAD51 reduces risk of squamous cell carcinoma of the head and neck and interacts with a P53 codon 72 variant.

Journal Article Carcinogenesis · May 2007 RAD51 participates in homologous recombination (HR) repair of double-stranded DNA breaks (DSBs) that may cause genomic instability and cancer. Two single-nucleotide polymorphisms (SNPs) and three P53 binding sites have been found in the RAD51 promoter and ... Full text Link to item Cite

Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility: a case-control analysis.

Journal Article Breast Cancer Res Treat · May 2007 The BRCA1 Associated RING Domain (BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a c ... Full text Link to item Cite

Genetic variants in MGMT and risk of lung cancer in Southeastern Chinese: a haplotype-based analysis.

Journal Article Hum Mutat · May 2007 O6-alkylguanine-DNA alkyltransferase (MGMT) is a universal DNA repair protein involved in the DNA direct reversal repair pathway that copes with alkylating carcinogens. Reduced MGMT expression as well as enzyme activity may result in an increased susceptib ... Full text Link to item Cite

Polymorphisms of the neuronal and inducible nitric oxide synthase genes and the risk of cutaneous melanoma: a case-control study.

Journal Article Cancer · April 15, 2007 BACKGROUND: Nitric oxide (NO) is a multifunctional molecule that is produced by both neuronal NO synthase (nNOS) and inducible NO synthase (iNOS), and the expression of nNOS and iNOS is up-regulated in various cancer cells, including cutaneous melanoma (CM ... Full text Link to item Cite

In vitro expression levels of cell-cycle checkpoint proteins are associated with cellular DNA repair capacity in peripheral blood lymphocytes: a multivariate analysis.

Journal Article J Proteome Res · April 2007 DNA repair should occur after cells sense DNA damage signals and undergo cell-cycle arrest to provide sufficient time for DNA repair, and suboptimal DNA repair capacity (DRC) in peripheral lymphocytes has been suggested as a cancer susceptibility marker. N ... Full text Link to item Cite

Genetic variants of the vitamin D receptor gene alter risk of cutaneous melanoma.

Journal Article J Invest Dermatol · February 2007 Sunlight causes DNA damage but also induces production of vitamin D whose metabolite 1,25-(OH)2D3 has antiproliferative and pro-differentiative effects in both melanocytes and cutaneous melanoma (CM) cells mediated through the vitamin D receptor (VDR). We ... Full text Link to item Cite

4-Nitroquinoline-1-oxide-induced mutagen sensitivity and risk of nonmelanoma skin cancer: a case-control analysis.

Journal Article J Invest Dermatol · January 2007 The UV radiation-mimetic chemical 4-nitroquinoline-1-oxide (4-NQO) is thought to induce squamous cell carcinoma (SCC) similar to those induced by UV radiation in animals. Therefore, we tested the hypothesis that cellular sensitivity to 4-NQO is associated ... Full text Link to item Cite

Expression of heat shock proteins in myocardium of patients with atrial fibrillation.

Journal Article Cell Stress Chaperones · 2007 Atrial fibrillation (AF) is the most common sustained arrhythmia. Because heat shock proteins (Hsp) can protect cells from stress, we compared the levels of Hsp60, Hsp72, Hsc73, and Hsp27 in atrial myocardium from 17 patients with AF (8 paroxysmal and 9 pe ... Full text Link to item Cite

DNA repair, genetic instability, and cancer

Book · January 1, 2007 This volume describes the elaborate surveillance systems and various DNA repair mechanisms that ensure accurate passage of genetic information onto daughter cells. In particular, it narrates how the cell cycle checkpoint and DNA repair machineries detect a ... Full text Cite

Molecular epidemiology of DNA repair and cancer susceptibility- a review of population-based studies

Chapter · January 1, 2007 The role of DNA repair in the etiology of cancer has been well illustrated in several hereditary syndromes, in which an inherited defect in DNA repair is associated with an extraordinarily high incidence of cancer. However, such an association between an i ... Full text Cite

Preface

Book · January 1, 2007 Full text Cite

Polymorphisms in the DNA repair genes XPC, XPD, and XPG and risk of cutaneous melanoma: a case-control analysis.

Journal Article Cancer Epidemiol Biomarkers Prev · December 2006 Sunlight causes DNA damage, including bulky lesions that are removed effectively by the nucleotide-excision repair (NER) pathway. There are at least eight core NER proteins participating in the pathway, and genetic variations in their genes may alter NER f ... Full text Link to item Cite

Association of genetic variants of O6-methylguanine-DNA methyltransferase with risk of lung cancer in non-Hispanic Whites.

Journal Article Cancer Epidemiol Biomarkers Prev · December 2006 O6-methylguanine, a methylated damage lesion in DNA, correlates with spontaneous G:C --> A:T transition mutations and leads to activation of oncogene K-ras or dysfunction of the tumor suppressor gene p53. O6-methylguanine-DNA methyltransferase (MGMT) is cr ... Full text Link to item Cite

Repair of UV-induced DNA damage and melanoma risk

Journal Article · December 1, 2006 Melanoma is relatively uncommon compared with nonmelanoma skin cancers, but it causes a vast majority of skin-cancer deaths. Sunlight exposure, particularly intermittent sun exposure early in life, is a well-established risk factor for melanoma. Because on ... Full text Cite

Polymorphisms and haplotypes of the NBS1 gene are associated with risk of sporadic breast cancer in non-Hispanic white women

Journal Article Carcinogenesis · November 2006 DNA double-strand breaks (DSBs) may lead to genomic instability and cancer if unrepaired. Nijmegen breakage syndrome 1 (NBS1) protein is one of the key proteins that participates in recognition and repair of DSBs in humans. We hypothesized that polymorphis ... Full text Link to item Cite

Promoter polymorphism (-786t>C) in the endothelial nitric oxide synthase gene is associated with risk of sporadic breast cancer in non-Hispanic white women age younger than 55 years.

Journal Article Cancer · November 1, 2006 BACKGROUND: Nitric oxide (NO) is constitutively synthesized in the endothelium by endothelial nitric oxide synthase (eNOS) and acts as a pleiotropic regulator involved in carcinogenesis. Most breast cancers develop from mammary epithelial cells; therefore, ... Full text Link to item Cite

Variant genotypes of CDKN1A and CDKN1B are associated with an increased risk of breast cancer in Chinese women.

Journal Article Int J Cancer · November 1, 2006 p21(Cip1) and p27(Kip1) are cyclin-dependent kinase inhibitors, which can arrest cell proliferation and serve as tumor suppressors. Reduced protein expression of p21(Cip1) and p27(Kip1) was frequently observed in a subset of cancers, including breast cance ... Full text Link to item Cite

Benzo(a)pyrene inhibits expression of inducible heat shock protein 70 in vascular endothelial cells.

Journal Article Toxicol Lett · October 25, 2006 Benzo(a)pyrene (BaP), a ubiquitous environmental pollutant known to cause many diseases including atherosclerosis, induces a dose-dependent reduction in the levels of the inducible Hsp70. To explore the mechanism underlying the reduction of Hsp70, we measu ... Full text Link to item Cite

MDM2 gene promoter polymorphisms and risk of lung cancer: a case-control analysis.

Journal Article Carcinogenesis · October 2006 The MDM2 protein negatively regulates p53 expression level in modulating DNA repair, cell-cycle control, cell growth and apoptosis. Polymorphisms in the promoter region of the MDM2 gene have been shown to alter protein expression and may, thus, play a role ... Full text Link to item Cite

The association of polymorphisms of CDT1 and GMNN gene with the risk of breast cancer in Chinese women: a case-control analysis.

Journal Article Zhonghua Yi Xue Yi Chuan Xue Za Zhi · October 2006 OBJECTIVE: To investigate the association of polymorphisms of CDT1 and GMNN gene, two important genes participating in DNA replication, with the risk of sporadic breast cancer. METHODS: Using polymerase chain reaction-restriction fragment length polymorphi ... Link to item Cite

Polymorphisms of FAS and FAS ligand genes involved in the death pathway and risk and progression of squamous cell carcinoma of the head and neck.

Journal Article Clin Cancer Res · September 15, 2006 PURPOSE: Alteration of the FAS/FAS ligand (FASLG) pathway regulating cell death may lead to cancer development, but the effects of functional promoter polymorphisms of the FAS and FASLG genes on risk of squamous cell carcinoma of the head and neck (SCCHN) ... Full text Link to item Cite

Genetic variants of the ADPRT, XRCC1 and APE1 genes and risk of cutaneous melanoma.

Journal Article Carcinogenesis · September 2006 Sunlight causes various kinds of DNA damage, including oxidative lesions that are removed effectively by the base excision repair (BER) pathway, in which ADPRT, XRCC1 and APE1 play a key role. However, genetic variation in these genes may alter their funct ... Full text Link to item Cite

Association of polymorphisms in AhR, CYP1A1, GSTM1, and GSTT1 genes with levels of DNA damage in peripheral blood lymphocytes among coke-oven workers.

Journal Article Cancer Epidemiol Biomarkers Prev · September 2006 Accumulating evidence has shown that both DNA damage caused by the metabolites of polycyclic aromatic hydrocarbons (PAH) and genetic polymorphisms in PAH-metabolic genes contribute to individual susceptibility to PAH-induced carcinogenesis. However, the fu ... Full text Link to item Cite

Transplantation and aging.

Journal Article Biol Blood Marrow Transplant · September 2006 Full text Link to item Cite

Beta-2 adrenergic receptor gene (ADRB2) polymorphism and risk for lung adenocarcinoma: a case-control study in a Chinese population.

Journal Article Cancer Lett · August 28, 2006 The incidence of lung adenocarcinoma (AC) has been increasing over recent decades. The tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is one of the most potent carcinogens and reproducibly induces a high incidence of lung AC in lab ... Full text Link to item Cite

Polymorphisms in the MDM2 promoter and risk of breast cancer: a case-control analysis in a Chinese population.

Journal Article Cancer Lett · August 28, 2006 MDM2 is a phosphoprotein that interacts with P53 and inhibits its activity. Recently, a T/G substitution (SNP309) in the promoter of MDM2 was identified and has been demonstrated to be associated with an increased MDM2 expression and a significantly earlie ... Full text Link to item Cite

Glutathione S-transferase polymorphisms and risk of differentiated thyroid carcinomas: a case-control analysis.

Journal Article Arch Otolaryngol Head Neck Surg · July 2006 OBJECTIVE: To determine the association between glutathione S-transferase (GST) polymorphisms and the risk of differentiated thyroid carcinoma (DTC) and benign thyroid tumors. DESIGN: Case-control study. SETTING: Tertiary care cancer center. PATIENTS: Two ... Full text Link to item Cite

Polymorphisms in DNA damage binding protein 2 (DDB2) and susceptibility of primary lung cancer in the Chinese: a case-control study.

Journal Article Carcinogenesis · July 2006 DNA damage binding protein 2 (DDB2) is one of the major DNA repair proteins involved in the nucleotide excision repair (NER) pathway. Mutations in the DDB2 gene can cause a repair-deficiency syndrome xeroderma pigmentosum group E. Because tobacco carcinoge ... Full text Link to item Cite

Polymorphisms in the two helicases ERCC2/XPD and ERCC3/XPB of the transcription factor IIH complex and risk of lung cancer: a case-control analysis in a Chinese population.

Journal Article Cancer Epidemiol Biomarkers Prev · July 2006 The transcription factor IIH (TFIIH) helicases ERCC2/XPD and ERCC3/XPB are responsible for opening the DNA strand around the lesion site during nucleotide excision repair process. Genetic variants in these two genes may be markers for interindividual varia ... Full text Link to item Cite

Reliability of mutagen sensitivity assay: an inter-laboratory comparison.

Journal Article Mutagenesis · July 2006 Mutagen sensitivity is regarded as a genetic susceptibility phenotype for various cancers; it is cytogenetically based and probably involves a number of genes from different DNA repair pathways. This assay has been used in a number of laboratories in the f ... Full text Link to item Cite

Effects of Brn-3a protein and RNA expression in rat brain following low-level lead exposure during development on spatial learning and memory.

Journal Article Toxicol Lett · June 20, 2006 The developing nervous system is preferentially vulnerable to lead exposure with alterations in neuronal and glial cells of the brain. Chronic exposure to lead (Pb2+) causes deficits of learning and memory in children and spatial learning deficits in devel ... Full text Link to item Cite

A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer.

Journal Article Oncogene · June 15, 2006 X-ray repair cross-complementing 1 (XRCC1) plays a key role in DNA base excision repair and cells lacking its activity are hypersensitive to DNA damage. Recently, we reported a SNP (rs3213245, -77T>C) in the XRCC1 gene 5' untranslated region (UTR) was sign ... Full text Link to item Cite

Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis.

Journal Article BMC Cancer · May 25, 2006 BACKGROUND: Accumulative evidence suggests that low folate intake is associated with increased risk of breast cancer. Polymorphisms in genes involved in folate metabolism may influence DNA methylation, nucleotide synthesis, and thus individual susceptibili ... Full text Open Access Link to item Cite

Functional variants in the promoter of interleukin-1beta are associated with an increased risk of breast cancer: a case-control analysis in a Chinese population.

Journal Article Int J Cancer · May 15, 2006 Interleukin 1beta (IL-1beta) is a multifunctional cytokine that upregulates the inflammatory response, and participates in carcinogenesis, malignant transformation, tumor growth, invasion and metastasis. Two potentially functional polymorphisms (T-31C and ... Full text Link to item Cite

DNMT3b polymorphism and hereditary nonpolyposis colorectal cancer age of onset.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2006 Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant syndrome of familial malignancies resulting from germ-line mutations in DNA mismatch repair genes. Colorectal and endometrial cancers are most frequently observed. A polymorphic C-t ... Full text Link to item Cite

Polymorphisms of the FAS and FAS ligand genes associated with risk of cutaneous malignant melanoma.

Journal Article Pharmacogenet Genomics · April 2006 The FAS/FAS ligand (FASLG) system has a key role in regulating cell growth and thus tumorigenesis. Functional promoter polymorphisms of the FAS and FASLG genes alter the transcriptional activities, but no published study has investigated the role of these ... Full text Link to item Cite

Characterization of 67 kD laminin receptor, a protein whose gene is overexpressed on treatment of cells with anti-benzo[a]pyrene-7,8-diol-9,10-epoxide.

Journal Article Toxicol Sci · April 2006 The molecular mechanisms potentially related to tumorigenesis induced by anti-benzo[a]pyrene-7,8-diol-9,10-epoxide (anti-BPDE) were investigated by suppression subtractive hybridization of the human bronchial epithelial cells (16HBE) carcinoma induced by B ... Full text Link to item Cite

Functional polymorphisms in the promoter regions of the FAS and FAS ligand genes and risk of bladder cancer in south China: a case-control analysis.

Journal Article Pharmacogenet Genomics · April 2006 BACKGROUND: FAS and FASLG together initiate apoptosis, which prevents tumor development. FAS and FASLG polymorphisms in the promoter regions can alter the transcriptional activities and thus alter risk of cancer. We hypothesized that the FAS -1377G>A, -670 ... Full text Link to item Cite

Joint effects of single nucleotide polymorphisms in P53BP1 and p53 on breast cancer risk in a Chinese population.

Journal Article Carcinogenesis · April 2006 p53-binding protein 1 (P53BP1), a central transducer of DNA-damage signals to p53, is required for both intra-S-phase and G2-M checkpoints, suggesting that these two proteins may work together in the p53-mediated transcriptional activation and DNA damage-r ... Full text Link to item Cite

Survival prediction in patients with glioblastoma multiforme by human telomerase genetic variation.

Journal Article J Clin Oncol · April 1, 2006 PURPOSE: Glioblastoma multiforme (GBM) is the most common and aggressive glioma with the poorest survival. Use of biomarkers for screening patients with GBM may be used to modify treatments and improve outcomes. The level of human telomerase (hTERT) expres ... Full text Link to item Cite

Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population.

Journal Article Int J Cancer · March 1, 2006 Overexpression of MDM2 may attenuate the P53 stress response pathway through direct blocking of P53 transcriptional activity and mediating P53 degradation. Two promoter polymorphisms (one is a T to G substitution at the intronic P53-response promoter, and ... Full text Link to item Cite

Polymorphism at the 3'-UTR of the thymidylate synthase gene: a potential predictor for outcomes in Caucasian patients with esophageal adenocarcinoma treated with preoperative chemoradiation.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2006 PURPOSE: To test the hypothesis that TS3'UTR polymorphisms predict outcomes in 146 Caucasian patients with esophageal adenocarcinoma treated with preoperative 5-fluorouracil-based chemoradiation. METHODS AND MATERIALS: DNA was extracted from hematoxylin-an ... Full text Link to item Cite

The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration.

Journal Article Cancer Biol Ther · March 2006 Allelic loss of the short arm of chromosome 1 has been observed frequently in oligodendroglioma (60-80%). We evaluated 177 oligodendroglial tumor samples and defined a consensus region of deletion of approximately 630 kb. This region contains a single gene ... Full text Link to item Cite

Association of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers.

Journal Article Cell Stress Chaperones · 2006 Severe noise exposure can induce heat shock proteins (Hsps), and exposure to moderate noise has been reported to confer protection against noise-induced damage to hearing. Whether there is any association of genetic variation in both constitutive and induc ... Full text Link to item Cite

Combined effects of the p53 and p73 polymorphisms on lung cancer risk.

Journal Article Cancer Epidemiol Biomarkers Prev · January 2006 Lung cancer is a multigenic disease where one variant single nucleotide polymorphism may have only a modest independent effect on the disease phenotype, yet in aggregate, multiple biologically relevant single nucleotide polymorphisms may provide a more acc ... Full text Link to item Cite

[Estimation on gene-environment interaction in the partial case-control study].

Journal Article Zhonghua Liu Xing Bing Xue Za Zhi · January 2006 OBJECTIVE: To introduce the approaches for estimating gene-environment interaction based on partial case-control studies. METHODS: The effects of logistic model and log-linear model for estimating the main effects and gene-environment interaction effect we ... Link to item Cite

Overexpressed heat shock protein 70 protects cells against DNA damage caused by ultraviolet C in a dose-dependent manner.

Journal Article Cell Stress Chaperones · 2006 Heat shock protein 70 (Hsp70) comprises proteins that have been reported to protect cells, tissues, and organisms against damage from a wide variety of stressful stimuli; however, little is known about whether Hsp70 protects against DNA damage. In this stu ... Full text Link to item Cite

In vitro sensitivity to ultraviolet B light and skin cancer risk: a case-control analysis.

Journal Article J Natl Cancer Inst · December 21, 2005 BACKGROUND: Mutagen sensitivity, measured as mutagen-induced chromatid breaks per cell in primary lymphocytes in vitro, has been used to study susceptibility to various epithelial cancers. Patients with xeroderma pigmentosum are highly sensitive to ultravi ... Full text Link to item Cite

Houston AANCART best practices: from vision to synergy to reality.

Journal Article Cancer · December 15, 2005 The theme for the 2004 AANCART Academy, "Community Partnerships for Cancer Control: From Vision to Synergy to Reality", characterizes Best Practices for the Houston AANCART site. Researchers and community members share a common vision for addressing the ca ... Full text Link to item Cite

Polymorphisms of thymidylate synthase in the 5'- and 3'-untranslated regions associated with risk of gastric cancer in South China: a case-control analysis.

Journal Article Carcinogenesis · October 2005 Fruits and certain vegetables have a protective effect on gastric cancer (GC) and folate is one of the nutrients in fruits and vegetables. We hypothesized that the polymorphisms of thymidylate synthase (TYMS) gene involved in folate metabolism are associat ... Full text Link to item Cite

Exon 3 polymorphisms and haplotypes of O6-methylguanine-DNA methyltransferase and risk of bladder cancer in southern China: a case-control analysis.

Journal Article Cancer Lett · September 8, 2005 Methylating agents are involved in bladder carcinogenesis. O6-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein that removes methyl group from O6-methylguanine and thus plays an important role in the etiology of cancer. We hypothesized tha ... Full text Link to item Cite

Genetic polymorphisms of p21 are associated with risk of squamous cell carcinoma of the head and neck.

Journal Article Carcinogenesis · September 2005 The p21 (Waf1/Cip1/CDKN1A) protein regulates the transition from the G1 to the S phase and has an important role in modulating cell-cycle control, apoptosis and cell growth. Two polymorphisms of the p21 gene at codon 31 (p21 C98A, dbSNP rs1801270) and at t ... Full text Link to item Cite

Expression of nucleotide excision repair proteins in lymphocytes as a marker of susceptibility to squamous cell carcinomas of the head and neck.

Journal Article Cancer Epidemiol Biomarkers Prev · August 2005 The transcript levels of nucleotide excision repair (NER) genes were shown to be associated with risk of squamous cell carcinomas of the head and neck (SCCHN). However, this association may be biased, because the transcript level does not necessarily refle ... Full text Link to item Cite

Functional polymorphisms of matrix metalloproteinase-9 are associated with risk of occurrence and metastasis of lung cancer.

Journal Article Clin Cancer Res · August 1, 2005 PURPOSE: Matrix metalloproteinase 9 (MMP-9) plays critical roles in cancer development and aggression. Nonsynonymous single-nucleotide polymorphisms (SNP) in the functional domain of the MMP-9 gene may influence substrate and inhibitor binding and contribu ... Full text Link to item Cite

Polymorphisms and haplotypes of serine hydroxymethyltransferase and risk of squamous cell carcinoma of the head and neck: a case-control analysis.

Journal Article Pharmacogenet Genomics · August 2005 Low dietary intake of fruits and vegetables, particularly folate deficiency, has been associated with the risk of squamous cell carcinoma of the head and neck (SCCHN). We hypothesized that polymorphisms of the cytosolic serine hydroxymethyltransferase (SHM ... Full text Link to item Cite

Polymorphisms of methionine synthase and methionine synthase reductase and risk of lung cancer: a case-control analysis.

Journal Article Pharmacogenet Genomics · August 2005 Although tobacco is the major lung cancer risk factor, folate deficiency has also been implicated as a risk. Methionine synthase (MS; gene symbol, MTR) and methionine synthase reductase (MSR; gene symbol, MTRR) play important roles in the folate metabolism ... Full text Link to item Cite

Methylation and messenger RNA expression of p15INK4b but not p16INK4a are independent risk factors for ovarian cancer.

Journal Article Clin Cancer Res · July 1, 2005 PURPOSE: The purpose of this research was to compare methylation status and mRNA expression of p15INK4b and p16INK4a in serous epithelial ovarian cancer tissues and normal ovarian tissues. EXPERIMENTAL DESIGN: We analyzed the DNA methylation status and mRN ... Full text Link to item Cite

A promoter polymorphism (-77T>C) of DNA repair gene XRCC1 is associated with risk of lung cancer in relation to tobacco smoking.

Journal Article Pharmacogenet Genomics · July 2005 X-ray repair cross complementing group 1 (XRCC1) is one of the major DNA repair proteins involved in the base-excision repair pathway. Functional Polymorphisms in the XRCC1 gene may lead to decreased DNA repair capacity and thus confer inherited predisposi ... Full text Link to item Cite

Gastrostomy in oropharyngeal cancer patients with ERCC4 (XPF) germline variants.

Journal Article Int J Radiat Oncol Biol Phys · July 1, 2005 PURPOSE: ERCC4 (XPF) plays a role in both recombinant DNA repair and nucleotide excision repair, which involve repairing radiation-induced genetic damage. We hypothesized that two ERCC4 single-nucleotide polymorphisms are associated with normal-tissue toxi ... Full text Link to item Cite

XRCC1 polymorphisms and cancer risk: a meta-analysis of 38 case-control studies.

Journal Article Cancer Epidemiol Biomarkers Prev · July 2005 Several potential functional polymorphisms (Arg194Trp, Arg280His, Arg399Gln) in the DNA base excision repair gene X-ray repair cross-complementing group 1 (XRCC1) have been implicated in cancer risk. Our meta-analysis on total of 11,957 cancer cases and 14 ... Full text Link to item Cite

DNA repair gene XPC genotypes/haplotypes and risk of lung cancer in a Chinese population.

Journal Article Int J Cancer · June 20, 2005 DNA repair is central to normal cellular functions, and polymorphisms of DNA repair genes may cause variation in DNA repair capacity in the general population. Newly identified polymorphisms of xeroderma pigmentosum group C (XPC), one of the nucleotide exc ... Full text Link to item Cite

Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk.

Journal Article Clin Cancer Res · June 15, 2005 PURPOSE: Genetic polymorphisms of DNA repair genes seem to determine the DNA repair capacity, which in turn may affect the risk of breast cancer. To evaluate the role of genetic polymorphisms of DNA repair genes in breast cancer, we conducted a hospital-ba ... Full text Link to item Cite

Radiation response genotype and risk of differentiated thyroid cancer: a case-control analysis.

Journal Article Laryngoscope · June 2005 BACKGROUND: Radiation is the only clear etiologic agent for differentiated thyroid cancer (DTC). Understanding the factors affecting sensitivity to gamma radiation and susceptibility to DTC will be critical to early detection and prevention of DTC. HYPOTHE ... Full text Link to item Cite

RET polymorphisms and haplotypes and risk of differentiated thyroid cancer.

Journal Article Laryngoscope · June 2005 OBJECTIVE: To determine whether common (allele frequencies > 5%) single nucleotide polymorphisms located in exons 2, 7, 11, 13, 14, and 15 of the RET proto-oncogene are associated with risk of differentiated thyroid carcinoma (DTC). STUDY DESIGN: Hospital- ... Full text Link to item Cite

Sex differences in risk of lung cancer associated with methylene-tetrahydrofolate reductase polymorphisms.

Journal Article Cancer Epidemiol Biomarkers Prev · June 2005 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the metabolism of folate and nucleotides needed for DNA synthesis and repair. Variations in MTHFR functions likely play roles in the etiology of lung cancer. The MTHFR gene has three nonsynonymous singl ... Full text Link to item Cite

Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: a case-control analysis.

Journal Article Int J Cancer · May 20, 2005 Folate deficiency is implicated in cancer risk that may be modulated by a genetic variation in the methylenetetrahydrofolate reductase (MTHFR) gene in folate metabolism. We hypothesized that genetic variants in MTHFR are associated with risk of squamous ce ... Full text Link to item Cite

Polymorphisms of methionine synthase and methionine synthase reductase and risk of squamous cell carcinoma of the head and neck: a case-control analysis.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2005 Although tobacco and alcohol use are the major risk factors, folate deficiency has been implicated in the risk of squamous cell carcinoma of the head and neck (SCCHN). We hypothesized that polymorphisms of methionine synthase (MTR) and methionine synthase ... Full text Link to item Cite

Dinucleotide polymorphism of p73 gene is associated with a reduced risk of lung cancer in a Chinese population.

Journal Article Int J Cancer · April 10, 2005 p73, a structural and functional homologue of p53, shares some p53-like tumor suppressor activity but also possesses oncogenic activity. Therefore, p73 plays an important role in modulating cell-cycle control and apoptosis. A potentially functional dinucle ... Full text Link to item Cite

A common polymorphism in the 3'UTR of cyclooxygenase 2/prostaglandin synthase 2 gene and risk of lung cancer in a Chinese population.

Journal Article Lung Cancer · April 2005 Cyclooxygenases (COXs) are key enzymes that convert arachidonic acid to prostaglandins. Overexpression of COX-2, one of the COX isozymes, has been shown to be an early event in lung carcinogenesis and may play an important role in lung cancer development. ... Full text Link to item Cite

Genetic polymorphisms of ataxia telangiectasia mutated and breast cancer risk.

Journal Article Cancer Epidemiol Biomarkers Prev · April 2005 To evaluate the role of genetic polymorphisms of ataxia telangiectasia mutated (ATM) in the etiology of breast cancer, a hospital-based case-control study was conducted in Korea. Nine-hundred ninety-six histologically confirmed incident breast cancer cases ... Full text Link to item Cite

Polymorphisms of vitamin D receptor gene protect against the risk of head and neck cancer.

Journal Article Pharmacogenet Genomics · March 2005 Vitamin D has potent anti-tumour properties. Calcitriol [1,25(OH)2D3], the hormonal derivative of vitamin D3, is an antiproliferative and prodifferentiation factor for several cell types, including human squamous cells of the head and neck. Several polymor ... Full text Link to item Cite

Case-control analysis of thymidylate synthase polymorphisms and risk of lung cancer.

Journal Article Carcinogenesis · March 2005 Although tobacco smoking is the primary risk factor for lung cancer, low dietary folate intake and suboptimal DNA repair capacity also contribute to lung cancer risk. Thymidylate synthase (TYMS) is involved in the metabolism of folate and the provision of ... Full text Link to item Cite

Plasma antibodies against heat shock protein 70 correlate with the incidence and severity of asthma in a Chinese population.

Journal Article Respir Res · February 14, 2005 BACKGROUND: The heat shock proteins (Hsps) are induced by stresses such as allergic factors and inflammatory responses in bronchi epithelial cells and therefore may be detectable in patients with asthma. However, the etiologic link between anti-Hsps and as ... Full text Open Access Link to item Cite

A pilot case-control study of gamma-radiation sensitivity and risk of papillary thyroid cancer.

Journal Article Thyroid · February 2005 In vitro gamma-radiation-induced chromatid breaks per cell (b/c) in lymphocytes may be associated with risk of papillary thyroid cancer (PTC). This pilot case-control study involved 106 patients with thyroid disease (57 with PTC and 49 with benign thyroid ... Full text Link to item Cite

Nucleotide excision repair as a marker for susceptibility to tobacco-related cancers: a review of molecular epidemiological studies.

Journal Article Mol Carcinog · February 2005 DNA repair is a complicated biological process consisting of several distinct pathways that play a central role in maintaining genomic stability. Research on DNA repair and cancer risk is a vital, emerging field that recently has seen rapid advances facili ... Full text Link to item Cite

Methylenetetrahydrofolate reductase polymorphisms/haplotypes and risk of gastric cancer: a case-control analysis in China.

Journal Article Oncol Rep · February 2005 Studies have suggested that low dietary folate intake is associated with an increased risk of gastric cancer. Methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism and influences DNA methylation and nucleotide synthesis. MTHFR is hig ... Link to item Cite

Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer.

Journal Article Cancer Res · February 1, 2005 Adenosine diphosphate ribosyl transferase (ADPRT) and X-ray repair cross-complementing 1 (XRCC1) are two major DNA base excision repair (BER) proteins and act interactively in stimulating and executing BER processes. Polymorphisms of ADPRT Val762Ala and XR ... Link to item Cite

A pilot study of Helicobacter pylori infection and risk of laryngopharyngeal cancer.

Journal Article Head Neck · January 2005 BACKGROUND: Squamous cell carcinoma of the laryngopharynx has been linked to laryngopharyngeal reflux disease. Helicobacter pylori corpus gastritis decreases gastric acid secretion and provides some protection against complications of gastroesophageal refl ... Full text Link to item Cite

Association of hsp70-2 and hsp-hom gene polymorphisms with risk of acute high-altitude illness in a Chinese population.

Journal Article Cell Stress Chaperones · 2005 High-altitude illness (HAI) is a potentially fatal condition involving genetic and environmental components. Accumulated experimental evidence suggests that heat shock proteins (Hsps), especially HSP70, can protect cells and organs against different types ... Full text Link to item Cite

Plasma antibodies to heat shock protein 60 and heat shock protein 70 are associated with increased risk of electrocardiograph abnormalities in automobile workers exposed to noise.

Journal Article Cell Stress Chaperones · 2005 In the living and working environment, stressful factors, such as noise, can cause health problems including cardiovascular diseases and noise-induced hearing loss. Some heat shock proteins (Hsps) play an important role in protecting cardiac cells against ... Full text Link to item Cite

Head and neck cancers

Chapter · January 1, 2005 Head and neck cancers, also known as cancers of the upper aerodigestive tract, are chiefly squamous cell carcinomas arising in the oral cavity, pharynx, or larynx. About 40,000 persons are diagnosed with squamous cell carcinoma of the head and neck (SCCHN) ... Cite

Descriptive epidemiology and risk factors for head and neck cancer.

Journal Article Semin Oncol · December 2004 Although more common in developing countries, over 11,000 deaths will occur in the United States from head and neck cancer in 2004. Squamous cell carcinomas account for the vast majority of cases in the United States and the majority of these are related t ... Full text Link to item Cite

Thymidylate synthase 5'- and 3'-untranslated region polymorphisms associated with risk and progression of squamous cell carcinoma of the head and neck.

Journal Article Clin Cancer Res · December 1, 2004 PURPOSE: Folate deficiency and reduced DNA repair capacity are established risk factors for squamous cell carcinoma of the head and neck (SCCHN). We hypothesized that polymorphisms of the thymidylate synthase (TYMS) gene, which regulates a key enzyme in fo ... Full text Link to item Cite

Interleukin-1B gene promoter variants are associated with an increased risk of gastric cancer in a Chinese population.

Journal Article Cancer Lett · November 25, 2004 Studies suggest that IL-1beta (encoded by IL-1B gene) is a pro-inflammatory cytokine and potent inhibitor of gastric acid secretion, which is proposed as a key determinant in gastric carcinogenesis. Two potentially functional polymorphisms (C-31T and T-511 ... Full text Link to item Cite

Repair of mitomycin C cross-linked DNA in mammalian cells measured by a host cell reactivation assay.

Journal Article Mol Cells · October 31, 2004 DNA repair capacity in a cell could be detected by a host-cell reactivation assay (HCR). Since relation between DNA repair and genetic susceptibility to cancer remains unclear, it is necessary to identify DNA repair defects in human cancer cells. To assess ... Link to item Cite

Association of a p73 exon 2 G4C14-to-A4T14 polymorphism with risk of squamous cell carcinoma of the head and neck.

Journal Article Carcinogenesis · October 2004 p73, a novel p53 homolog, has some p53-like activity and plays an important role in modulating cell-cycle control, apoptosis and cell growth. p73 regulates differentiation of head and neck squamous epithelium, and changes in p73 may lead to the development ... Full text Link to item Cite

DNA repair gene XPD polymorphism and lung cancer risk: a meta-analysis.

Journal Article Lung Cancer · October 2004 Interindividual variation in lung cancer susceptibility may be modulated in part through genetic polymorphisms in the DNA repair genes, especially the genes involved in the nucleotide excision repair (NER) pathway. The xeroderma pigmentosum complementary g ... Full text Link to item Cite

Matched-pair analysis of survival of never smokers and ever smokers with squamous cell carcinoma of the head and neck.

Journal Article J Clin Oncol · October 1, 2004 PURPOSE: To compare survival rates between patients with squamous cell carcinoma of the head and neck (SCCHN) without a history of smoking (never smokers) and those with a current or previous history of smoking (ever smokers). PATIENTS AND METHODS: Fifty n ... Full text Link to item Cite

p73 G4C14-to-A4T14 polymorphism and risk of lung cancer.

Journal Article Cancer Res · October 1, 2004 Genetic variants in genes controlling cellular processes such as cell cycle, DNA repair, and apoptosis may modulate lung cancer risk. p73 has some p53-like activity and plays an important role in modulating these processes. The noncoding region of exon 2 o ... Full text Link to item Cite

Correlation of lymphocyte heat shock protein 70 levels with neurologic deficits in elderly patients with cerebral infarction.

Journal Article Am J Med · September 15, 2004 PURPOSE: To assess the association between heat shock protein 70 (HSP70) levels and the severity of ischemic stroke in elderly patients. METHODS: We conducted a case-control study to investigate the changes in lymphocyte HSP70 levels by immunoblot in 65 el ... Full text Link to item Cite

Reduced DNA repair of benzo[a]pyrene diol epoxide-induced adducts and common XPD polymorphisms in breast cancer patients.

Journal Article Carcinogenesis · September 2004 Environmental chemicals are thought to play a role in the etiology of breast cancer, because polycyclic acromatic hydrocarbon (PAH)-DNA adducts are detectable in normal and malignant breast tissues. Peripheral blood lymphocytes (PBLs) from female breast ca ... Full text Link to item Cite

Polymorphisms of DNA repair genes and risk of glioma.

Journal Article Cancer Res · August 15, 2004 DNA repair genes play a major role in maintaining genomic stability through different repair pathways that are mediated by cell cycle control genes such as p53. We found previously that glioma patients were susceptible to gamma-ray-induced chromosomal brea ... Full text Link to item Cite

Disruption of the Rad9/Rad1/Hus1 (9-1-1) complex leads to checkpoint signaling and replication defects.

Journal Article Oncogene · July 22, 2004 The checkpoint sliding-clamp complex, Rad9/Rad1/Hus1, plays a critical role during initiation of checkpoint signals in response to DNA damage and replication disruption. We investigated the impact of loss of Rad1 on checkpoint function and on DNA replicati ... Full text Link to item Cite

Gamma radiation-induced apoptosis, G2 delay, and the risk of salivary and thyroid carcinomas--a preliminary report.

Journal Article Head Neck · July 2004 BACKGROUND: While radiation has been the only well-established risk factor for salivary and thyroid cancers, the exact mechanisms remain unknown. We hypothesized that individuals with altered apoptotic response to gamma irradiation may be susceptible to sa ... Full text Link to item Cite

Matched analysis of survival in patients with squamous cell carcinoma of the head and neck diagnosed before and after 40 years of age.

Journal Article Arch Otolaryngol Head Neck Surg · July 2004 OBJECTIVES: To compare the survival rates of patients 40 years or younger and diagnosed with squamous cell carcinoma of the head and neck (SCCHN) with those of patients older than 40 years who underwent the same treatment. In 2 previous matched-pair analys ... Full text Link to item Cite

Association between the V109G polymorphism of the p27 gene and the risk and progression of oral squamous cell carcinoma.

Journal Article Clin Cancer Res · June 15, 2004 PURPOSE: Abnormalities in p27 may alter cell cycle delay required for DNA repair after exposure to carcinogens. A coding exon 1 polymorphism at codon 109 (T-->G) in p27 was identified and thought to have an effect on the functions of its protein. We hypoth ... Full text Link to item Cite

Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma.

Journal Article Cancer Res · June 15, 2004 The etiology of esophageal squamous cell carcinoma (ESCC) has been shown to be associated with genetic and certain environmental factors that produce DNA damage. Base excision repair (BER) genes are responsible for repair of DNA damage caused by reactive o ... Full text Link to item Cite

P53 codon 72 polymorphism and risk of gastric cancer in a Chinese population.

Journal Article Oncol Rep · May 2004 The p53 gene plays an important role in cell cycle control in response to DNA damage, which may increase the probability of mutations that lead to carcinogenesis. The p53 codon 72 Arg right curved arrow Pro polymorphism has been suggested to be associated ... Link to item Cite

Glutathione S-transferase polymorphisms and survival in primary malignant glioma.

Journal Article Clin Cancer Res · April 15, 2004 PURPOSE: The purpose of this research was to investigate the relationship between glutathione S-transferase (GST) polymorphisms and survival, and chemotherapy-related toxicity in 278 glioma patients. EXPERIMENTAL DESIGN: We determined genetic variants for ... Full text Link to item Cite

Polymorphisms of DNA repair gene XRCC3 Thr241Met and risk of gastric cancer in a Chinese population.

Journal Article Cancer Lett · March 31, 2004 Mammalian cells are constantly exposed to a wide variety of genotoxic agents from both endogenous and exogenous sources. Genetic variability in DNA repair may contribute to human cancer risk. In this population-based case-control study in China, we tested ... Full text Link to item Cite

Serum and lymphocyte levels of heat shock protein 70 in aging: a study in the normal Chinese population.

Journal Article Cell Stress Chaperones · March 2004 Heat shock proteins (Hsps) have been reported to play an important role in both physiological and pathological processes. Hsps also may serve as biomarkers for evaluating disease states and exposure to environmental stresses. Whether Hsp levels in serum an ... Full text Link to item Cite

Gamma radiation sensitivity and risk of malignant and benign salivary gland tumors: a pilot case-control analysis.

Journal Article Cancer · February 1, 2004 BACKGROUND: The salivary gland is a highly radiosensitive organ. Exposure to gamma radiation is a risk factor for both malignant (MSTs) and benign salivary gland tumors (BSTs), but the exact mechanisms remain unknown. The objectives of the current study we ... Full text Link to item Cite

Frequency-specific association of antibodies against heat shock proteins 60 and 70 with noise-induced hearing loss in Chinese workers.

Journal Article Cell Stress Chaperones · 2004 Noise exposure may result in production of auto-antibodies against heat shock proteins (Hsps), which might be of significance in the pathogenesis or prognosis (or both) of auto-immune ear diseases. However, it is not known whether these antibodies are asso ... Full text Link to item Cite

Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review.

Journal Article Am J Epidemiol · January 1, 2004 Possession of the fast metabolizing alleles for alcohol dehydrogenase (ADH), ADH1B*2 and ADH1C*1, and the null allele for aldehyde dehydrogenase (ALDH), ALDH2*2, results in increased acetylaldehyde levels and is hypothesized to increase the risk of head an ... Full text Link to item Cite

Serum and lymphocyte levels of heat shock protein 70 in aging: A study in the normal Chinese population

Journal Article Cell Stress and Chaperones · 2004 Heat shock proteins (Hsps) have been reported to play an important role in both physiological and pathological processes. Hsps also may serve as biomarkers for evaluating disease states and exposure to environmental stresses. Whether Hsp levels in serum an ... Full text Cite

p53 codon 72 Arg homozygotes are associated with an increased risk of cutaneous melanoma.

Journal Article J Invest Dermatol · December 2003 The p53 gene plays an important role in cell cycle control, facilitating DNA repair activities in response to DNA damage. Aberrant cell cycle control impairs DNA repair and increases the probability of mutations that can lead to carcinogenesis. The p53 gen ... Full text Link to item Cite

Smoking, DNA repair capacity and risk of nonsmall cell lung cancer.

Journal Article Int J Cancer · October 20, 2003 Tobacco-related carcinogens cause a variety of DNA damage that is repaired by different enzymatic pathways, suggesting that DNA repair plays an important role in tobacco-induced carcinogenesis. In a large hospital-based case-control study, we investigated ... Full text Link to item Cite

Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer.

Journal Article Oncogene · October 16, 2003 Chemoprevention has been widely explored as a promising strategy for controlling the incidence of lung cancer, the leading cause of cancer-related death. To maximize the benefit of lung cancer chemoprevention, it is important to identify individuals at hig ... Full text Link to item Cite

Association between low dietary folate intake and suboptimal cellular DNA repair capacity.

Journal Article Cancer Epidemiol Biomarkers Prev · October 2003 Both reduced DNA repair capacity (DRC) and folate deficiency are associated with increased cancer risk. Furthermore, folate is involved in DNA repair through de novo DNA synthesis and methylation. To determine whether low dietary folate intake is associate ... Link to item Cite

Fas A670G polymorphism, apoptotic capacity in lymphocyte cultures, and risk of lung cancer.

Journal Article Lung Cancer · October 2003 Tobacco carcinogens can damage DNA, leading to apoptosis. There may be individual variation in apoptotic capacity (AC), and this variation may explain difference in AC associated with risk of lung cancer, if genome integrity is not restored by efficient DN ... Full text Link to item Cite

Dietary folate intake and lung cancer risk in former smokers: a case-control analysis.

Journal Article Cancer Epidemiol Biomarkers Prev · October 2003 No studies have focused on the role of dietary folate intake in risk of lung cancer in former smokers, in whom dietary folate intake is less likely confounded with current smoking. Therefore, we evaluated the association between dietary folate intake and r ... Link to item Cite

Genetic susceptibility to lung cancer: the role of DNA damage and repair.

Journal Article Cancer Epidemiol Biomarkers Prev · August 2003 Link to item Cite

Human papillomavirus type 16 infection and squamous cell carcinoma of the head and neck in never-smokers: a matched pair analysis.

Journal Article Clin Cancer Res · July 2003 PURPOSE: Infection with human papillomavirus (HPV) type 16 has been suggested to be a risk factor for squamous cell carcinoma of the head and neck (SCCHN) and to be more commonly associated with SCCHN occurring in the oropharynx and in never-smokers. We hy ... Link to item Cite

Genomic instability and endoreduplication triggered by RAD17 deletion.

Journal Article Genes Dev · April 15, 2003 Cell cycle checkpoints are critical for genomic stability. Rad17, a component of the checkpoint clamp loader complex (Rad17/Rfc2-5), is required for the response to DNA damage and replication stress. To explore the role of Rad17 in the maintenance of genom ... Full text Link to item Cite

Overexpression of hMTH in peripheral lymphocytes and risk of prostate cancer: a case-control analysis.

Journal Article Mol Carcinog · March 2003 Oxidative damage is an important factor in prostate carcinogenesis, and overexpression of human MutT homolog (hMTH), a repair gene that removes oxidative damage, is a molecular marker of cellular oxidative stress. Therefore, we tested the hypothesis that o ... Full text Link to item Cite

Sample size for biomarker studies: more subjects or more measurements per subject?

Journal Article Ann Epidemiol · March 2003 PURPOSE: In molecular epidemiologic studies, optimizing the use of available biological specimens while minimizing the cost is always a challenge. This is particularly true in pilot studies, which often have limited funding and involve small numbers of bio ... Full text Link to item Cite

XPA polymorphism associated with reduced lung cancer risk and a modulating effect on nucleotide excision repair capacity.

Journal Article Carcinogenesis · March 2003 XPA, a DNA binding protein in the nucleotide excision repair (NER) pathway, modulates damage recognition. Recently, a common single-nucleotide polymorphism (A --> G) of unknown function was identified in the 5' non-coding region of the XPA gene. Because a ... Full text Link to item Cite

Repair of UV light-induced DNA damage and risk of cutaneous malignant melanoma.

Journal Article J Natl Cancer Inst · February 19, 2003 BACKGROUND: The mechanism underlying the role of UV light exposure from sunlight in the etiology of cutaneous malignant melanoma (CMM) is unclear. Patients with xeroderma pigmentosum, a disease characterized by severe sensitivity to UV radiation and a defe ... Full text Link to item Cite

Genetic susceptibility for lung cancer: interactions with gender and smoking history and impact on early detection policies.

Journal Article Hum Hered · 2003 OBJECTIVES: To identify a subgroup of former, current and never smokers (males and females) at high risk for developing lung cancer, based on their genetic susceptibility profiles, to estimate their lifetime probabilities of the disease, and to assess the ... Full text Link to item Cite

Molecular Epidemiology of Head and Neck Cancer

Journal Article · January 1, 2003 This chapter focuses on the molecular epidemiological studies on the roles of carcinogen metabolism and DNA repair in susceptibility to squamous cell carcinoma of the head and neck (SCCHN). The major risk factors for oropharyngeal cancers, also known as he ... Full text Cite

Rapid assessment of repair of ultraviolet DNA damage with a modified host-cell reactivation assay using a luciferase reporter gene and correlation with polymorphisms of DNA repair genes in normal human lymphocytes.

Journal Article Mutat Res · November 30, 2002 As DNA repair plays an important role in genetic susceptibility to cancer, assessment of the DNA repair phenotype is critical for molecular epidemiological studies of cancer. In this report, we compared use of the luciferase (luc) reporter gene in a host-c ... Full text Link to item Cite

Polymorphisms of the DNA repair gene XPD and risk of lung cancer in a Chinese population.

Journal Article Lung Cancer · November 2002 Previous studies suggested that suboptimal DNA repair capacity is associated with cancer risk and that the Asp312Asn and Lys751Gln polymorphisms in the xeroderma pigmentosum complementary group D (XPD) gene may influence DNA repair capacity. We therefore t ... Full text Link to item Cite

P53 codon 72 polymorphism and risk of squamous cell carcinoma of the head and neck: a case-control study.

Journal Article Cancer Lett · September 26, 2002 p53 plays an important role in cell-cycle control, as it facilitates DNA repair activities in response to DNA damage. An aberrant cell cycle impairs DNA repair and increases the probability of mutations that lead to carcinogenesis. The p53 codon 72 Arg/Pro ... Full text Link to item Cite

A novel polymorphism in human cytosine DNA-methyltransferase-3B promoter is associated with an increased risk of lung cancer.

Journal Article Cancer Res · September 1, 2002 DNA repair is central to genomic integrity. Reduced expression of several nucleotide excision repair genes has been demonstrated to be associated with increased risk of lung cancer. Because methylation of gene promoters is one of the major regulatory mecha ... Link to item Cite

DNA repair gene ERCC1 and ERCC2/XPD polymorphisms and risk of squamous cell carcinoma of the head and neck.

Journal Article Arch Otolaryngol Head Neck Surg · September 2002 OBJECTIVE: To determine the effect of the ERCC1 C8092A polymorphism and the ERCC2/XPD G23591A polymorphism on the risk of squamous cell carcinoma of the head and neck (SCCHN). DESIGN: A hospital-based case-control study. SUBJECTS: A total of 330 newly diag ... Full text Link to item Cite

An analysis of DNA repair as a determinant of survival in patients with non-small-cell lung cancer.

Journal Article J Natl Cancer Inst · July 17, 2002 BACKGROUND: Non-small-cell lung cancer (NSCLC) is frequently resistant to chemotherapy, and this resistance has been associated with elevated nucleotide excision repair (NER) in tumor tissue. We hypothesized that patients with NSCLC who had effective syste ... Full text Link to item Cite

Haplotypes of two variants in p16 (CDKN2/MTS-1/INK4a) exon 3 and risk of squamous cell carcinoma of the head and neck: a case-control study.

Journal Article Cancer Epidemiol Biomarkers Prev · July 2002 The frequent loss or promoter methylation of the tumor suppressor gene p16 in head and neck cancer suggests an etiologic role of p16 in this disease. Two adjacent polymorphisms of p16 exon 3, C540G and C580T, were identified recently. C540G is associated w ... Link to item Cite

XPD/ERCC2 EXON 8 Polymorphisms: rarity and lack of significance in risk of squamous cell carcinoma of the head and neck.

Journal Article Oral Oncol · July 2002 BACKGROUND: Inherited polymorphisms of DNA repair genes may contribute to genetic susceptibility to squamous cell carcinoma of the head and neck (SCCHN). The objective was to assess whether two polymorphisms in the nucleotide excision repair gene XPD (ERCC ... Full text Link to item Cite

N-(4-hydroxyphenyl)retinamide (4-HPR) modulates GADD45 expression in radiosensitive bladder cancer cell lines.

Journal Article Cancer Lett · June 28, 2002 We previously demonstrated that N-(4-hydroxyphenyl)retinamide (4-HPR) and gamma-irradiation, when used in combination, had a synergistic effect in inducing apoptosis in bladder cancer cells, suggesting that 4-HPR may increase radiosensitivity in bladder ca ... Full text Link to item Cite

A variant of the DNA repair gene XRCC3 and risk of squamous cell carcinoma of the head and neck: a case-control analysis.

Journal Article Int J Cancer · June 20, 2002 Individuals differ in their ability to repair DNA damage induced by carcinogens. Studies have shown that polymorphisms in DNA repair genes contribute to individual variation in DNA repair capacity and cancer risk. In a hospital-based case-control study, we ... Full text Link to item Cite

Polymorphism of DNA ligase I and risk of lung cancer--a case-control analysis.

Journal Article Lung Cancer · June 2002 DNA ligases catalyze the joining of single and double-strand DNA breaks, which is an essential step in DNA replication, recombination and repair. Recently, a common single nucleotide polymorphism (A-->C) in exon 6 of DNA ligase I (LIG1) was identified, but ... Full text Link to item Cite

Genetic susceptibility--molecular epidemiology of head and neck cancer.

Journal Article Curr Opin Oncol · May 2002 In parts of the developing world (South Central Asia in particular), squamous cell carcinoma of the head and neck (SCCHN) is one of the most common malignancies encountered. Although tobacco and alcohol are clearly defined as etiologic factors in these mal ... Full text Link to item Cite

Expression of nucleotide excision repair genes and the risk for squamous cell carcinoma of the head and neck.

Journal Article Cancer · January 15, 2002 BACKGROUND: Phenotypic differences in the ability to repair genetic damage induced by tobacco carcinogens may reflect genetic differences in susceptibility to squamous cell carcinoma of the head and neck (SCCHN). The objective of this study was to assess t ... Full text Link to item Cite

Age-associated changes in DNA repair and mutation rates

Journal Article Advances in Cell Aging and Gerontology · December 1, 2001 Full text Cite

Polymorphic hCHK2/hCds1 codon 84 allele and risk of squamous cell carcinoma of the head and neck--a case-control analysis.

Journal Article Carcinogenesis · December 2001 Checkpoint kinase 2 (hCHK2/hCds1) is a tumor suppressor gene involved in cell-cycle control. A hCHK2/hCds1 polymorphism in codon 84 (A-->G at nucleotide 252) was recently identified in Li-Fraumeni syndrome patients. Because cell cycle regulates DNA repair ... Full text Link to item Cite

Sensitivity to benzo(a)pyrene diol-epoxide associated with risk of breast cancer in young women and modulation by glutathione S-transferase polymorphisms: a case-control study.

Journal Article Cancer Res · December 1, 2001 Mounting epidemiological evidence suggests that smoking may play a role in the etiology of breast cancer. Because smoking-related DNA adducts are detectable in both normal and malignant breast tissues, we hypothesized that breast cancer patients may be sen ... Link to item Cite

Gamma-radiation sensitivity and risk of glioma.

Journal Article J Natl Cancer Inst · October 17, 2001 BACKGROUND: About 9% of human cancers are brain tumors, of which 90% are gliomas. gamma-Radiation has been identified as a risk factor for brain tumors. In a previous pilot study, we found that lymphocytes from patients with glioma were more sensitive to g ... Full text Link to item Cite

Polymorphisms of 5,10-methylenetetrahydrofolate reductase and risk of gastric cancer in a Chinese population: a case-control study.

Journal Article Int J Cancer · September 20, 2001 Low dietary folate intake has been associated with increased risk of gastric cancer. The 5,10-methylenetetrahydrofolate reductase (MTHFR) involved in folate metabolism has 2 variants, C677T and A1298C, that result in decreased MTHFR activity and lower plas ... Full text Link to item Cite

Cyclin D1 polymorphism and risk for squamous cell carcinoma of the head and neck: a case-control study.

Journal Article Carcinogenesis · August 2001 A G-->A polymorphism (G870A) in exon 4 of the cyclin D1 (CCND1) gene creates an alternative splice site in its mRNA, encoding a protein with an altered C-terminal domain. It has been suggested that DNA damage in cells with the A allele bypasses the G(1)/S ... Full text Link to item Cite

In vitro BPDE-induced DNA adducts in peripheral lymphocytes as a risk factor for squamous cell carcinoma of the head and neck.

Journal Article Int J Cancer · August 1, 2001 The level of DNA adducts under the same conditions of carcinogen exposure and cell proliferation reflects an integrated measure of carcinogen metabolism and DNA repair. Therefore, such DNA adduct levels have the potential to be a biomarker for susceptibili ... Full text Link to item Cite

Reduced expression of hMSH2 and hMLH1 and risk of prostate cancer: a case-control study.

Journal Article Prostate · June 1, 2001 BACKGROUND: Although prostate cancer is the most common incident cancer in men, not much is known about its etiology. We tested the hypothesis that expression levels of hMSH2 and hMLH1 in unaffected (normal) tissue play a role in the etiology of prostate c ... Full text Link to item Cite

Cryopreserving whole blood for functional assays using viable lymphocytes in molecular epidemiology studies.

Journal Article Cancer Lett · May 26, 2001 There is an increasing need for viable lymphocytes in performing phenotypic assays for biomarker studies. Both fresh and cryopreserved lymphocytes have been used for cell culture-based functional assays. However, fresh lymphocytes do not allow assays to be ... Full text Link to item Cite

An intronic poly (AT) polymorphism of the DNA repair gene XPC and risk of squamous cell carcinoma of the head and neck: a case-control study.

Journal Article Cancer Res · April 15, 2001 Inherited polymorphisms of DNA repair genes may contribute to variations in DNA repair capacity and genetic susceptibility to cancer. In a hospital-based case-control study of 287 non-Hispanic white patients with newly diagnosed SCCHN and 311 control subje ... Link to item Cite

Methylenetetrahydrofolate reductase polymorphisms increase risk of esophageal squamous cell carcinoma in a Chinese population.

Journal Article Cancer Res · April 15, 2001 Methylenetetrahydrofolate reductase (MTHFR) plays a central role in folate metabolism that affects DNA methylation and synthesis. Because germ-line mutations at nucleotides 677 (C-->T) and 1298 (A-->C) in the MTHFR gene cause diminished enzyme activity, an ... Link to item Cite

Polymorphisms of methylene-tetrahydrofolate reductase and risk of lung cancer: a case-control study.

Journal Article Cancer Epidemiol Biomarkers Prev · April 2001 Previous studies have suggested that low folate intake is associated with increased risk of lung cancer. Methylene-tetrahydrofolate reductase (MTHFR) is one of the enzymes involved in folate metabolism and is thought to influence DNA methylation and nucleo ... Link to item Cite

Alcohol dehydrogenase 3 genotype is not associated with risk of squamous cell carcinoma of the oral cavity and pharynx.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2001 Alcohol is one of the major risk factors for oral and pharyngeal cancer. The rate-limiting step in alcohol metabolism is the oxidation (activation) of ethanol to acetaldehyde by the alcohol dehydrogenases (ADHs). It has been hypothesized that individuals w ... Link to item Cite

Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients.

Journal Article Cancer Res · February 15, 2001 Sequence variations have been identified in a number of DNA repair genes, including XPD, but the effect of these polymorphisms on DNA repair capacity (DRC) is uncertain. We therefore examined XPD polymorphisms at Lys751Gln and Asp312Asn in 341 white lung c ... Link to item Cite

Sensitivity to DNA damage induced by benzo(a)pyrene diol epoxide and risk of lung cancer: a case-control analysis.

Journal Article Cancer Res · February 15, 2001 Levels of DNA adducts vary greatly in vivo, attributable to individual differences in enzymatic bioactivation of benzo(a)pyrene. We developed an assay to measure the levels of DNA adducts induced in vitro by benzo(a)pyrene diol epoxide (BPDE), a bioactivat ... Link to item Cite

Risk assessment for developing gliomas: a comparison of two cytogenetic approaches.

Journal Article Mutat Res · January 25, 2001 Chromosome instability (CIN) measured as chromosome aberrations has long been suggested as a cancer susceptibility biomarker. Conventional cytogenetic end-points are now being improved by combining molecular methods, which increases the sensitivity, specif ... Full text Link to item Cite

DNA repair capacity in healthy medical students during and after exam stress.

Journal Article J Behav Med · December 2000 There has been extensive research into the effects of stress on immune function but little on the effects of stress on DNA repair capacity (DRC), a process central to maintaining a normal cell cycle. Defective DRC is one of the factors responsible for carc ... Full text Link to item Cite

XPD/ERCC2 polymorphisms and risk of head and neck cancer: a case-control analysis.

Journal Article Carcinogenesis · December 2000 DNA repair capacity is central in maintaining normal cellular functions. Variants of several DNA repair genes,including the nucleotide excision repair gene XPD, have been described recently. Because we previously reported that patients with squamous cell c ... Full text Link to item Cite

Polymorphisms of the DNA repair gene XRCC1 and risk of gastric cancer in a Chinese population.

Journal Article Int J Cancer · November 15, 2000 Gastric cancer remains the leading cause of cancer death in China and other countries in eastern Asia. Studies of gastric cancer have revealed that it is a disease of complex etiology involving dietary, infectious, environmental, occupational and genetic f ... Full text Link to item Cite

Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: a molecular epidemiologic study.

Journal Article J Natl Cancer Inst · November 1, 2000 BACKGROUND: Only a fraction of cigarette smokers develop lung cancer, suggesting that people differ in their susceptibility to this disease. We investigated whether differences in DNA repair capacity (DRC) for repairing tobacco carcinogen-induced DNA damag ... Full text Link to item Cite

Low-dose genistein induces cyclin-dependent kinase inhibitors and G(1) cell-cycle arrest in human prostate cancer cells.

Journal Article Mol Carcinog · October 2000 Genistein, a naturally occurring isoflavone found chiefly in soy products, reportedly has antiprostate cancer effects, but the mechanisms underlying these effects are unknown. We studied the antiproliferative and apoptosis-inducing effects of genistein in ... Full text Link to item Cite

Reduced expression levels of nucleotide excision repair genes in lung cancer: a case-control analysis.

Journal Article Carcinogenesis · August 2000 Epidemiological studies have indicated that reduced DNA repair capacity and increased DNA adduct levels are associated with increased risk of lung cancer. Nucleotide excision repair (NER) is the major pathway in humans for repairing DNA adducts induced by ... Link to item Cite

Gender difference in smoking effect on chromosome sensitivity to gamma radiation in a healthy population.

Journal Article Radiat Res · July 2000 In the general population, there is variation in radiosensitivity associated with cancer risk. However, data on the role of epigenetic factors in the variation of radiosensitivity are scarce. Thus we investigated the effects of smoking and age on the radio ... Full text Link to item Cite

DNA repair: a double-edged sword.

Journal Article J Natl Cancer Inst · March 15, 2000 Full text Link to item Cite

Informed consent for tissue research.

Journal Article JAMA · November 3, 1999 Link to item Cite

Polymorphisms of DNA repair gene XRCC1 in squamous cell carcinoma of the head and neck.

Journal Article Carcinogenesis · November 1999 Because reduced DNA repair capacity (phenotype) has been suggested as a risk factor for squamous cell carcinoma of the head and neck (SCCHN), newly-identified DNA repair gene polymorphisms (genotype) may also be implicated in risk. To test this hypothesis, ... Full text Link to item Cite

Expression in normal human tissues of five nucleotide excision repair genes measured simultaneously by multiplex reverse transcription-polymerase chain reaction.

Journal Article Cancer Epidemiol Biomarkers Prev · September 1999 DNA repair is central to the integrity of the human genome. Reduced DNA repair capacity has been linked to genetic susceptibility to cancer. An adequate expression level of DNA repair genes is essential for normal DNA repair activities. Although there is t ... Link to item Cite

Glutathione-S-transferase polymorphisms and risk of squamous-cell carcinoma of the head and neck.

Journal Article Int J Cancer · June 21, 1999 Differences in genetic susceptibility to tobacco-induced carcinogenesis appear to modulate an individual's risk of squamous-cell carcinoma of the head and neck (SCCHN). Risk for SCCHN may be associated with the null alleles of the carcinogen-metabolizing g ... Full text Link to item Cite

Increased chromosomal instability in peripheral lymphocytes and risk of human gliomas.

Journal Article Carcinogenesis · May 1999 Brain tumors exhibit considerable chromosome instability (CIN), suggesting that genetic susceptibility may contribute to brain tumorigenesis. To test this hypothesis, in this pilot study, we examined for CIN in short-term lymphocyte cultures from 25 adult ... Full text Link to item Cite

DNA repair in lymphoblastoid cell lines from patients with head and neck cancer.

Journal Article Arch Otolaryngol Head Neck Surg · February 1999 OBJECTIVE: To analyze and compare components of the 3 primary DNA repair pathways of Epstein-Barr virus-transformed lymphocyte (lymphoblastoid) cell lines derived from 9 patients with squamous cell carcinoma of the head and neck and 11 cancer-free controls ... Full text Link to item Cite

Genetic susceptibility to tobacco carcinogenesis.

Journal Article Cancer Invest · 1999 Lung cancer risk is thus defined by the balance between metabolic activation and detoxification of xenobiotic compounds and by the efficiency of DNA repair. It is most likely that multiple susceptibility factors must be accounted for to represent the true ... Full text Link to item Cite

Gamma-ray mutagen sensitivity and survival in patients with glioma.

Journal Article Clin Cancer Res · December 1998 Despite advances in treatment of brain tumors, cerebral malignant gliomas are rapidly debilitating with poor survival. Patient age and tumor histology are known to influence survival in glioma patients, but these factors do not account for all of the varia ... Link to item Cite

Combined effect of chemopreventive agent N-(4-hydroxyphenyl) retinamide (4-HPR) and gamma-radiation on bladder cancer cell lines.

Journal Article Int J Oncol · November 1998 The incidence of bladder cancer has increased in the United States during the past 50 years, consistent with increased exposure to bladder carcinogens in the environment and tobacco use. Although N-(4-hydroxyphenyl) retinamide (4-HPR), a retinoid derivativ ... Full text Link to item Cite

Effect of aging on DNA repair and skin carcinogenesis: a minireview of population-based studies.

Journal Article J Investig Dermatol Symp Proc · August 1998 In the general population, the risk of developing sunlight-induced skin cancer increases as age increases. During the aging process, many biologic factors contribute to the increased risk of developing cancer, including increasing cumulative carcinogenic e ... Link to item Cite

Mutagen sensitivity to benzo(a)pyrene diol epoxide and the risk of squamous cell carcinoma of the head and neck.

Journal Article Clin Cancer Res · July 1998 Genetic susceptibility appears to modulate an individual's risk of tobacco-induced carcinoma. One biomarker of such susceptibility, chromatid breaks induced in vitro in lymphocytes by the mutagen bleomycin, is an independent risk factor for several maligna ... Link to item Cite

Genetic polymorphisms in glutathione S-transferase mu and theta, N-acetyltransferase, and CYP1A1 and risk of gliomas.

Journal Article Cancer Epidemiol Biomarkers Prev · June 1998 The role of genetic polymorphisms in modulating susceptibility to carcinogenic exposures has been well explored for tobacco-related neoplasms but not for other neoplasms including gliomas. It is relevant to explore these polymorphisms because certain carci ... Link to item Cite

Reduced DNA repair capacity in head and neck cancer patients.

Journal Article Cancer Epidemiol Biomarkers Prev · June 1998 Head and neck cancers (HNCs) are malignancies that can be induced by tobacco use, although host-specific factors such as the DNA repair capacity (DRC) may modulate individual susceptibility to tobacco carcinogenesis. To test the hypothesis that genetically ... Link to item Cite

Reduced expression of mismatch repair genes in colorectal cancer patients in Egypt.

Journal Article Int J Oncol · June 1998 An Egyptian hospital-based pilot case-control study was conducted to investigate the relationship between the expression level of mismatch repair (MMR) genes and the risk of colorectal cancer. The relative expression of five known MMR genes, i.e., hMSH2, h ... Full text Link to item Cite

Reduced expression of hMLH1 and hGTBP/hMSH6: a risk factor for head and neck cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · April 1998 Head and neck cancer, like lung cancer, is considered a paradigm of an environmentally induced disease. Genetically determined variation in DNA repair capacity is thought to contribute to susceptibility to tobacco-related cancers. In this molecular epidemi ... Link to item Cite

DNA repair and genomic instability in tobacco induced malignancies of the lung and upper aerodigestive tract

Journal Article Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews · January 1, 1998 Molecular epidemiologic studies using biomarkers (TABLE II) of cancer susceptibility provide a means of identifying genetically susceptible individuals or subpopulations at high risk of developing cancer. Currently, interindividual variation in response to ... Full text Cite

Reduced expression of mismatch repair genes measured by multiplex reverse transcription-polymerase chain reaction in human gliomas.

Journal Article Cancer Res · May 1, 1997 Microsatellite instability (MIN) is frequently observed in hereditary nonpolyposis colon cancer and in other sporadic cancers including gliomas. Abnormalities in at least one of five mismatch repair (MMR) genes are implicated in the development of cancers ... Link to item Cite

Direct correlation between DNA repair capacity and metastatic potential of K-1735 murine melanoma cells.

Journal Article J Invest Dermatol · January 1997 The purpose of this study was to determine whether the ability of K-1735 murine melanoma cells to repair DNA damage correlates with their metastatic potential. Three nonmetastatic clones, four metastatic clones, and three somatic-cell hybrids between metas ... Full text Link to item Cite

Expression of five selected human mismatch repair genes simultaneously detected in normal and cancer cell lines by a nonradioactive multiplex reverse transcription-polymerase chain reaction.

Journal Article Pathobiology · 1997 Abnormalities in at least 1 of 5 mismatch repair (MMR) genes (hMSH2, hMLH1, hPMS1, hPMS2 and GTBP/hMSH6) are found in hereditary nonpolyposis colon cancer and sporadic colon cancers. We used a single-reaction multiplex reverse transcription (RT)-polymerase ... Full text Link to item Cite

The role of DNA repair capacity in susceptibility to lung cancer: a review.

Journal Article Cancer Metastasis Rev · 1997 Human cancer risk assessment has relied largely on animal experiments and use of short-term biological tests based on chemical-DNA interaction. The recent introduction of biomarkers to molecular epidemiologic studies has provided another means of assessing ... Full text Link to item Cite

Reduced DNA repair capacity in lung cancer patients.

Journal Article Cancer Res · September 15, 1996 Although lung cancer is the paradigm of a tobacco-induced malignancy, host-specific factors modulate susceptibility to tobacco carcinogenesis. Variations in DNA repair may influence the rate of removal of DNA damage and of fixation of mutations. To test th ... Link to item Cite

Benzo(a)pyrene diol epoxide-induced chromosomal aberrations and risk of lung cancer.

Journal Article Cancer Res · September 1, 1996 Benzo(a)pyrene is considered a classic DNA-damaging carcinogen and is one of a multitude of polycyclic aromatic hydrocarbons commonly found in tobacco smoke and in the ambient environment. In this report, we describe the characteristics of chromosomal aber ... Link to item Cite

Fluorescence in situ hybridization method for measuring transfection efficiency.

Journal Article Biotechniques · September 1996 We describe here the use of fluorescence in situ hybridization (FISH) to measure the transfection efficiency of the transient expression vector pCMVcat in lymphoblasts and fibroblasts. By using a pCMVcat probe, we can visualize the location of the plasmid ... Full text Link to item Cite

In vitro induction of benzo(a)pyrene diol epoxide-DNA adducts in peripheral lymphocytes as a susceptibility marker for human lung cancer.

Journal Article Cancer Res · August 15, 1996 Given the same exposure, DNA adduct profiles can be considered as a phenotypic marker for carcinogen metabolism and DNA repair, which may reflect individual susceptibility to chemical carcinogenesis. Based on this notion, we have established a straightforw ... Link to item Cite

Mutagen sensitivity and risk of gliomas: a case-control analysis.

Journal Article Cancer Res · April 1, 1996 Although the risk factors contributing to the etiology of brain tumors remain largely unknown, this pilot study suggests that genetically determined sensitivity to environmental carcinogens may play a role in the pathogenesis of these tumors. In this study ... Link to item Cite

DNA repair and epidemiology of basal cell carcinoma.

Journal Article Clin Chem · December 1995 In a molecular epidemiological study of DNA repair, host reactivation assay was used to measure the DNA repair capacity of cryopreserved lymphocytes from 88 primary basal cell carcinoma (BCC) patients and 135 cancer-free controls. In this study population, ... Link to item Cite

Simultaneous amplification of four DNA repair genes and beta-actin in human lymphocytes by multiplex reverse transcriptase-PCR.

Journal Article Cancer Res · November 1, 1995 We describe here the development, optimization, and use of a non-radioactive, quantitative, multiplex reverse transcriptase-PCR technique to measure, in a single reaction, the relative levels of the transcripts of four DNA repair genes (XPCC, hMSH2, XRCC1, ... Link to item Cite

DNA repair capacity for ultraviolet light-induced damage is reduced in peripheral lymphocytes from patients with basal cell carcinoma.

Journal Article J Invest Dermatol · June 1995 Sunlight exposure and certain host factors such as red hair and fair skin are established risk factors for non-melanoma skin cancers. Because deficient DNA repair capacity has contributed to the development of skin cancers in a rare genetic disease, xerode ... Full text Link to item Cite

Prospective study of occupational asthma to laboratory animal allergens: stability of airway responsiveness to methacholine challenge for one year.

Journal Article J Allergy Clin Immunol · March 1995 The stability of airway hyperresponsiveness was studied in a group of 178 young adults working with laboratory animals. At the time of their entry into the study, 132 of 178 subjects (74%) had less than 20% response to the inhalation of 25 mg/ml methacholi ... Full text Link to item Cite

DNA repair and susceptibility to basal cell carcinoma: a case-control study.

Journal Article Am J Epidemiol · October 1, 1994 This study investigated the role of DNA repair in susceptibility to sunlight-induced basal cell carcinoma using a host cell reactivation assay in peripheral lymphocytes. The study included Maryland basal cell carcinoma patients and cancer-free dermatologic ... Full text Link to item Cite

Vitamin supplementation and reduced risk of basal cell carcinoma.

Journal Article J Clin Epidemiol · August 1994 A clinic-based case-control study was conducted to determine the association between vitamin supplement use and risk of basal cell carcinoma (BCC) of the skin. The subjects were 131 patients with histopathologically confirmed primary BCC and 200 cancer-fre ... Full text Link to item Cite

DNA repair related to multiple skin cancers and drug use.

Journal Article Cancer Res · January 15, 1994 Defective repair of sunlight-induced DNA photodamage, coupled with an unusually high occurrence of multiple primary basal cell carcinomas (BCCs), is the major characteristic of xeroderma pigmentosum. Our recent work has indicated that this etiological para ... Link to item Cite

DNA repair: A potential marker for cancer susceptibility

Journal Article Cancer Bulletin · January 1, 1994 DNA REPAIR in the etiology of cancer has been implicated in a rare genetic disease, xeroderma pigmentosum. Deficient repair and an extraordinarily high incidence of sunlight-induced skin cancers are coupled in xeroderma pigmentosum patients, which led to t ... Cite

Progression of basal cell carcinoma through loss of chromosome 9q and inactivation of a single p53 allele.

Journal Article Cancer Res · January 1, 1994 Basal cell carcinoma (BCC) of the skin represents a unique group of tumors strongly associated with exposure to UV light. Unlike squamous carcinoma of the skin, BCC is generally indolent, noninvasive, and rarely metastatic. To study the involvement of tumo ... Link to item Cite

DNA repair and aging in basal cell carcinoma: a molecular epidemiology study.

Journal Article Proc Natl Acad Sci U S A · February 15, 1993 This molecular epidemiology study examines the DNA-repair capacities (DRCs) of basal cell carcinoma (BCC) skin cancer patients (88) and their controls (135) by using a plasmid/host-cell reactivation assay. In this assay UV-damaged expression vector plasmid ... Full text Link to item Cite

Risk factors for increased airway responsiveness to methacholine challenge among laboratory animal workers.

Journal Article Am Rev Respir Dis · December 1992 As a first step in a prospective study of the incidence of asthma to laboratory animals, a group of 364 adults 18 to 48 yr of age who were beginning employment with laboratory animals were evaluated in terms of their past history, health status, allergy, a ... Full text Link to item Cite