Tien Yin Wong

Conference Ophthalmic Epidemiol · October 2020 AIMS: To assess contributions of dietary and genetic factors to ethnic differences in AMD prevalence. DESIGN: Population-based analytical study. METHODS: In the Blue Mountains Eye Study, Australia (European ancestry n = 2826) and Multi-Ethnic Cohort Study, ... Full text Link to item Cite

Validation of a novel diabetic retinopathy utility index using discrete choice experiments.

Journal Article Br J Ophthalmol · February 2020 BACKGROUND/AIMS: To validate a preference-based Diabetic Retinopathy Utility Index (DRU-I) using discrete choice experiment (DCE) methods and assess disutilities associated with vision-threatening DR (VTDR: severe non-proliferative DR, proliferative DR and ... Full text Link to item Cite

Six-year incidence and progression of diabetic retinopathy in Indian adults: the Singapore Indian Eye study.

Journal Article Br J Ophthalmol · December 2019 AIMS: Diabetes is a major public health problem in migrants and ethnic minorities worldwide. We determined the incidence and risk factors of diabetic retinopathy (DR) in migrant Indians living in Singapore. METHODS: We included data from 759 Indian adults ... Full text Link to item Cite

Is Myopia Associated with the Incidence and Progression of Diabetic Retinopathy?

Journal Article Am J Ophthalmol · December 2019 PURPOSE: We sought to determine the association of refractive error and its associated determinants (axial length [AL], anterior chamber depth, and corneal curvature) with the incidence and progression of diabetic retinopathy (DR). DESIGN: Population-based ... Full text Link to item Cite

Association between diabetic retinopathy and incident cognitive impairment.

Journal Article Br J Ophthalmol · November 2019 BACKGROUND/AIM: The relationship between diabetic retinopathy (DR) and cognitive impairment (CI) is unclear due to equivocal findings from cross-sectional studies and a lack of long-term data. In this population-based cohort study, we investigated the long ... Full text Link to item Cite

Normative pattern and determinants of outer retinal thickness in an Asian population: the Singapore Epidemiology of Eye Diseases Study.

Journal Article Br J Ophthalmol · October 2019 BACKGROUND/AIMS: To evaluate the distribution and determinants of outer retinal thickness in eyes without retinal diseases, using spectral-domain optical coherence tomography (SD-OCT). METHODS: Participants were recruited from the Singapore Epidemiology of ... Full text Link to item Cite

Glaucoma in myopia: diagnostic dilemmas.

Journal Article Br J Ophthalmol · October 2019 Myopic eyes have an increased risk of glaucoma. However, glaucomatous changes in a myopic eye are often difficult to detect. Classic structural and functional investigations to diagnose glaucoma may be confounded by myopia. Here, we identify some of the co ... Full text Link to item Cite

Associations of retinal microvascular caliber with intermediate phenotypes of large arterial function and structure: A systematic review and meta-analysis.

Journal Article Microcirculation · October 2019 OBJECTIVE: Intermediate phenotypes of microcirculation (retinal microvascular caliber) are associated with cardiovascular (CV) risk factors and independently predict CV events. However, the effect of microcirculation variation on the vascular system is unc ... Full text Link to item Cite

CHARACTERIZATION OF THE CHOROIDAL VASCULATURE IN MYOPIC MACULOPATHY WITH OPTICAL COHERENCE TOMOGRAPHIC ANGIOGRAPHY.

Journal Article Retina · September 2019 PURPOSE: To characterize the choriocapillaris (CC) in highly myopic eyes with myopic maculopathy, using optical coherence tomographic angiography. METHODS: Prospective, clinic-based study of 42 eyes of 38 patients with high myopia (≤-6 diopters and axial l ... Full text Link to item Cite

Beyond vision loss: the independent impact of diabetic retinopathy on vision-related quality of life in a Chinese Singaporean population.

Journal Article Br J Ophthalmol · September 2019 BACKGROUND/AIMS: To assess the independent impact of diabetic retinopathy (DR) on three domains of vision-related quality of life (VRQoL) in a Chinese Singapore population. METHODS: The Singapore Chinese Eye Study (n=3353; 2009-2011) was a population-based ... Full text Link to item Cite

Effects of bariatric surgery on retinal microvascular architecture in obese patients.

Journal Article Int J Obes (Lond) · September 2019 STUDY AIM: Retinal microvasculature changes reflect systemic small vessel damage from obesity. The impact of bariatric surgery induced weight loss on the microvasculature is relatively unknown. We hypothesized that weight loss following bariatric surgery w ... Full text Link to item Cite

Deep learning in ophthalmology: The technical and clinical considerations.

Journal Article Prog Retin Eye Res · September 2019 The advent of computer graphic processing units, improvement in mathematical models and availability of big data has allowed artificial intelligence (AI) using machine learning (ML) and deep learning (DL) techniques to achieve robust performance for broad ... Full text Link to item Cite

Influence of myopic macular degeneration severity on treatment outcomes with intravitreal aflibercept in the MYRROR study.

Journal Article Acta Ophthalmol · August 2019 PURPOSE: To determine the influence of baseline myopic macular degeneration (MMD) severity on outcomes with intravitreal aflibercept (IVT-AFL) in patients with myopic choroidal neovascularization (CNV). METHODS: MYRROR was a randomized, double-masked study ... Full text Link to item Cite

Racial differences and determinants of macular thickness profiles in multiethnic Asian population: the Singapore Epidemiology of Eye Diseases Study.

Journal Article Br J Ophthalmol · July 2019 AIM: To evaluate racial differences, and ocular and systemic determinants of macular thickness (MT), measured by spectral-domain optical coherence tomography (SD-OCT) in a normal multiethnic Asian population. METHOD: MT was measured from a 6×6 mm2 central ... Full text Link to item Cite

Prevalence and causes of vision loss in South-east Asia and Oceania in 2015: magnitude, temporal trends and projections.

Journal Article Br J Ophthalmol · July 2019 BACKGROUND: To assess prevalence and causes of vision impairment in South-east Asia and Oceania regions from 1990 to 2015 and to forecast the figures for 2020. METHODS: Based on a systematic review of medical literature, prevalence of blindness (presenting ... Full text Link to item Cite

Prevalence and causes of vision loss in North Africa and Middle East in 2015: magnitude, temporal trends and projections.

Journal Article Br J Ophthalmol · July 2019 BACKGROUND: To assess the prevalence and causes of vision impairment in North Africa and the Middle East (NAME) from 1990 to 2015 and to forecast projections for 2020. METHODS: Based on a systematic review of medical literature, the prevalence of blindness ... Full text Link to item Cite

Peripheral capillary non-perfusion in treatment-naïve proliferative diabetic retinopathy associates with postoperative disease activity 6 months after panretinal photocoagulation.

Journal Article Br J Ophthalmol · June 2019 BACKGROUND/AIMS: With the perspective to provide individualised panretinal laser photocoagulation (PRP) for proliferative diabetic retinopathy (PDR), we evaluated if retinal peripheral capillary non-perfusion (PCNP) and oximetry, as non-invasive markers of ... Full text Link to item Cite

The Informant AD8 Can Discriminate Patients with Dementia From Healthy Control Participants in an Asian Older Cohort.

Journal Article J Am Med Dir Assoc · June 2019 OBJECTIVES: The informant-AD8 (i-AD8) was found to be reliable in detecting cognitive impairment and dementia in tertiary and primary health care settings. We evaluated the discriminability of the i-AD8, as compared to other brief cognitive measures, and i ... Full text Link to item Cite

Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.

Journal Article Am J Epidemiol · June 1, 2019 A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide asso ... Full text Link to item Cite

The Effect of Gender on Visual Field Sensitivity: The Singapore Chinese Eye Study.

Journal Article Ophthalmic Epidemiol · June 2019 PURPOSE: Visual field (VF) sensitivity is known to be age-dependent, but there is a paucity of evidence on whether it is gender-dependent. We therefore investigated the effect of gender on VF sensitivity. METHODS: An observational study involving 491 adult ... Full text Link to item Cite

History of gestational diabetes mellitus and postpartum maternal retinal microvascular structure and function.

Journal Article Diabet Med · June 2019 Full text Link to item Cite

Retinal Nerve Fiber Layer Thickness in a Multiethnic Normal Asian Population: The Singapore Epidemiology of Eye Diseases Study.

Journal Article Ophthalmology · May 2019 PURPOSE: To describe variations in retinal nerve fiber layer (RNFL) thickness based on spectral-domain (SD) OCT in a multiethnic Asian population. DESIGN: Population-based, cross-sectional study. PARTICIPANTS: Ethnic Chinese, Malay, and Indian adults older ... Full text Link to item Cite

Artificial intelligence using deep learning to screen for referable and vision-threatening diabetic retinopathy in Africa: a clinical validation study.

Journal Article Lancet Digit Health · May 2019 BACKGROUND: Radical measures are required to identify and reduce blindness due to diabetes to achieve the Sustainable Development Goals by 2030. Therefore, we evaluated the accuracy of an artificial intelligence (AI) model using deep learning in a populati ... Full text Link to item Cite

Evaluation of deep convolutional neural networks for glaucoma detection.

Journal Article Jpn J Ophthalmol · May 2019 PURPOSE: To investigate the performance of deep convolutional neural networks (DCNNs) for glaucoma discrimination using color fundus images STUDY DESIGN: A retrospective study PATIENTS AND METHODS: To investigate the discriminative ability of 3 DCNNs, we u ... Full text Link to item Cite

Relationship Between Sleep and Symptoms of Tear Dysfunction in Singapore Malays and Indians.

Journal Article Invest Ophthalmol Vis Sci · May 1, 2019 PURPOSE: The purpose of this study was to investigate the association between sleep (duration and quality) and symptoms of dry eye in Singapore Malay and Indian adults. METHODS: This was a prospective cross-sectional study. A total of 3303 subjects aged 40 ... Full text Link to item Cite

Impact of systemic vascular risk factors on the choriocapillaris using optical coherence tomography angiography in patients with systemic hypertension.

Journal Article Sci Rep · April 9, 2019 We investigated the characteristics of the choriocapillaris flow voids using optical coherence tomography angiography (OCTA) in 85 patients (164 eyes) with hypertension (mean ± SD age, 56 ± 11 years; 45% women; 20% poorly controlled BP; 16% diabetes) who a ... Full text Link to item Cite

Spectral-Domain OCT Measurements in Alzheimer's Disease: A Systematic Review and Meta-analysis.

Journal Article Ophthalmology · April 2019 TOPIC: OCT is a noninvasive tool to measure specific retinal layers in the eye. The relationship of retinal spectral-domain (SD) OCT measurements with Alzheimer's disease (AD) and mild cognitive impairment (MCI) remains unclear. Hence, we conducted a syste ... Full text Link to item Cite

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.

Journal Article Nat Genet · April 2019 The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking i ... Full text Link to item Cite

EFFICACY AND SAFETY OF INTRAVITREAL AFLIBERCEPT AND RANIBIZUMAB IN ASIAN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: Subgroup Analyses From the VIEW Trials.

Journal Article Retina · March 2019 PURPOSE: To assess the treatment effect of intravitreal aflibercept and ranibizumab in Asian patients with neovascular age-related macular degeneration. METHODS: We evaluated data from VIEW 1 and VIEW 2, comparing functional and morphologic outcomes at Wee ... Full text Link to item Cite

Impact of hypertension on retinal capillary microvasculature using optical coherence tomographic angiography.

Journal Article J Hypertens · March 2019 OBJECTIVE: Reduction in capillary density or rarefaction is a hallmark of essential hypertension. We measured the retinal capillary density using noninvasive optical coherence tomographic angiography (OCT-A) in adults with treated systemic hypertension and ... Full text Link to item Cite

Association of Diabetic Retinopathy and Diabetic Kidney Disease With All-Cause and Cardiovascular Mortality in a Multiethnic Asian Population.

Journal Article JAMA Netw Open · March 1, 2019 IMPORTANCE: The association of diabetic microvascular complications such as diabetic retinopathy (DR) and diabetic kidney disease (DKD) with mortality in populations is not clear. OBJECTIVE: To examine the association of DR and DKD separately and jointly w ... Full text Link to item Cite

Myopia - A 21st Century Public Health Issue.

Journal Article Invest Ophthalmol Vis Sci · February 28, 2019 Full text Link to item Cite

Inter-relationship between ageing, body mass index, diabetes, systemic blood pressure and intraocular pressure in Asians: 6-year longitudinal study.

Journal Article Br J Ophthalmol · February 2019 BACKGROUND: To investigate the biological effect of ageing on intraocular pressure (IOP) and risk factors in a population-based cohort study of Malay and Indian adults. METHODS: Participants aged 40-80 years were recruited for baseline and 6-year follow-up ... Full text Link to item Cite

Artificial intelligence and deep learning in ophthalmology.

Journal Article Br J Ophthalmol · February 2019 Artificial intelligence (AI) based on deep learning (DL) has sparked tremendous global interest in recent years. DL has been widely adopted in image recognition, speech recognition and natural language processing, but is only beginning to impact on healthc ... Full text Link to item Cite

Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control.

Journal Article Diabetes · February 2019 To identify genetic variants associated with diabetic retinopathy (DR), we performed a large multiethnic genome-wide association study. Discovery included eight European cohorts (n = 3,246) and seven African American cohorts (n = 2,611). We meta-analyzed a ... Full text Link to item Cite

Potential retinal biomarkers for dementia: what is new?

Journal Article Curr Opin Neurol · February 2019 PURPOSE OF REVIEW: To summarize the current findings on clinical retinal diseases and retinal imaging changes with dementia, focusing on Alzheimer's disease. RECENT FINDINGS: Studies observed that clinical retinal diseases such as age-related macular degen ... Full text Link to item Cite

Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium.

Journal Article Am J Kidney Dis · February 2019 RATIONALE & OBJECTIVE: Chronic kidney disease (CKD) is complicated by abnormalities that reflect disruption in filtration, tubular, and endocrine functions of the kidney. Our aim was to explore the relationship of specific laboratory result abnormalities a ... Full text Link to item Cite

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

Journal Article Neurology · January 28, 2019 OBJECTIVE: To explore genetic and lifestyle risk factors of MRI-defined brain infarcts (BI) in large population-based cohorts. METHODS: We performed meta-analyses of genome-wide association studies (GWAS) and examined associations of vascular risk factors ... Full text Link to item Cite

Retinal microvasculature changes in amyloid-negative subcortical vascular cognitive impairment compared to amyloid-positive Alzheimer's disease.

Journal Article J Neurol Sci · January 15, 2019 BACKGROUND AND PURPOSE: To investigate small vessel abnormalities in patients with cognitive impairment, we compared retinal microvascular alterations between patients with cognitive impairment related to Alzheimer's disease (ADCI) and those with subcortic ... Full text Link to item Cite

Author Correction: Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases.

Journal Article Nat Commun · January 8, 2019 Emmanuelle Souzeau, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this Article. This has now been corrected in both the PDF and HTML versions of the Article. ... Full text Link to item Cite

Association of Diabetes With Central Corneal Thickness Among a Multiethnic Asian Population.

Journal Article JAMA Netw Open · January 4, 2019 IMPORTANCE: Thicker or thinner central corneas may lead to either overestimation or underestimation of intraocular pressure, which is the most important causal and treatable risk factor for glaucoma. However, the findings on the associations between diabet ... Full text Link to item Cite

Population genomics in South East Asia captures unexpectedly high carrier frequency for treatable inherited disorders.

Journal Article Genet Med · January 2019 PURPOSE: Genomic studies have demonstrated the necessity of ethnicity-specific population data to ascertain variant pathogenicity for disease diagnosis and treatment. This study examined the carrier prevalence of treatable inherited disorders (TIDs), where ... Full text Link to item Cite

Retinal vascular changes and right ventricular structure and function: the MESA-Right Ventricle and MESA-Eye studies

Journal Article Pulmonary Circulation · January 1, 2019 Retinal vessel diameters have been associated with left ventricular morphology and function but their relationship with the right ventricle (RV) has not been studied. We hypothesized that wider retinal venules and narrower retinal arterioles are associated ... Full text Cite

The use of real-world evidence for evaluating anti-vascular endothelial growth factor treatment of neovascular age-related macular degeneration.

Journal Article Surv Ophthalmol · 2019 Randomized controlled trials are the gold standard in medical research, providing evidence of the efficacy of a treatment in well-defined patient populations. By contrast, real-world studies explore the effectiveness of treatments in routine clinical pract ... Full text Link to item Cite

Simplified end stage renal failure risk prediction model for the low-risk general population with chronic kidney disease.

Journal Article PLoS One · 2019 BACKGROUND: Chronic kidney disease (CKD) contributes significant morbidity and mortality among Asians; hence interventions should focus on those most at-risk of progression. However, current end stage renal failure (ESRF) risk stratification tools are comp ... Full text Link to item Cite

Microvascular narrowing and BP monitoring: A single centre observational study.

Journal Article PLoS One · 2019 INTRODUCTION: Half of all hypertensive individuals have inadequately-controlled BP because monitoring methods are ineffective. This single centre study examined consecutive subjects undergoing 24 hour BP measurements for clinic and ambulatory BP levels, an ... Full text Link to item Cite

Recent advances in the applications of metabolomics in eye research.

Journal Article Anal Chim Acta · December 11, 2018 Metabolomics, the identification and quantitation of metabolites in a system, have been applied to identify new biomarkers or elucidate disease mechanism. In this review, we discussed the application of metabolomics in several ocular diseases and recent de ... Full text Link to item Cite

Six-Year Incidence of and Risk Factors for Cataract Surgery in a Multi-ethnic Asian Population: The Singapore Epidemiology of Eye Diseases Study.

Journal Article Ophthalmology · December 2018 PURPOSE: To report the 6-year incidence of cataract surgery in an Asian population-based cohort of Malay, Indian, and Chinese persons living in Singapore and factors associated with undergoing cataract surgery over the follow-up period. DESIGN: Population- ... Full text Link to item Cite

Periodontitis and multiple markers of cardiometabolic risk in the fourth decade: A cohort study.

Journal Article Community Dent Oral Epidemiol · December 2018 OBJECTIVES: To examine associations between periodontitis at ages 32 and 38 and a range of early cardiometabolic risk biomarkers at age 38. METHODS: Periodontal probing depth and bleeding on probing data collected during the age-32 and age-38 assessments i ... Full text Link to item Cite

An Automated Grading System for Detection of Vision-Threatening Referable Diabetic Retinopathy on the Basis of Color Fundus Photographs.

Journal Article Diabetes Care · December 2018 OBJECTIVE: The goal of this study was to describe the development and validation of an artificial intelligence-based, deep learning algorithm (DLA) for the detection of referable diabetic retinopathy (DR). RESEARCH DESIGN AND METHODS: A DLA using a convolu ... Full text Link to item Cite

Early atherosclerosis is associated with retinal microvascular changes in adolescents with type 1 diabetes.

Journal Article Pediatr Diabetes · December 2018 BACKGROUND/OBJECTIVE: Adolescents with type 1 diabetes have early macrovascular changes (increased intima-media thickness [IMT]) and early retinal changes that predict clinical disease in adulthood. We hypothesized that early changes in the macrovascular a ... Full text Link to item Cite

Association between Choroidal Thickness and Drusen Subtypes in Age-Related Macular Degeneration.

Journal Article Ophthalmol Retina · December 2018 PURPOSE: To evaluate the association between the choroidal thickness (CT) and the characteristics of drusen and exudative age-related macular degeneration (AMD) sub-phenotypes in Asian and white populations. DESIGN: Retrospective clinical cohort study. PAR ... Full text Link to item Cite

Interethnic analyses of blood pressure loci in populations of East Asian and European descent.

Journal Article Nat Commun · November 28, 2018 Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-ana ... Full text Link to item Cite

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

Journal Article Lancet · November 10, 2018 BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk-outcome ... Full text Open Access Link to item Cite

Peripheral retinal changes in highly myopic young Asian eyes.

Journal Article Acta Ophthalmol · November 2018 PURPOSE: To determine the type and prevalence of peripheral retinal changes and its relationship with axial length (AL) in a population of young Asian adult males. METHODS: This was a cross-sectional study of male subjects aged between 19 and 25 years old. ... Full text Link to item Cite

The Relationship of Retinal Vessel Geometric Characteristics to the Incidence and Progression of Diabetic Retinopathy.

Journal Article Ophthalmology · November 2018 PURPOSE: To examine the relationships of retinal vessel geometric characteristics (RVGCs) to the incidence and progression of diabetic retinopathy (DR). DESIGN: Observational, prospective cohort study. PARTICIPANTS: Nine hundred ninety-six persons with typ ... Full text Link to item Cite

A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes.

Journal Article Acta Ophthalmol · November 2018 PURPOSE: Diabetic retinopathy is the most common eye complication in patients with diabetes. The purpose of this study is to identify genetic factors contributing to severe diabetic retinopathy. METHODS: A genome-wide association approach was applied. In t ... Full text Link to item Cite

Impact of Ideal Cardiovascular Health in Childhood on the Retinal Microvasculature in Midadulthood: Cardiovascular Risk in Young Finns Study.

Journal Article J Am Heart Assoc · October 16, 2018 Background This study examined the association between ideal cardiovascular health ( CVH ) and the retinal microvasculature in midadulthood. Methods and Results The Cardiovascular Risk in Young Finns Study included children from 5 Finnish University cities ... Full text Link to item Cite

Risk of Incident Cardiovascular Disease and Cardiovascular Risk Factors in First and Second-Generation Indians: The Singapore Indian Eye Study.

Journal Article Sci Rep · October 4, 2018 Population-based data investigating generational differences in the risk of incident cardiovascular disease (CVD) and its risk determinants are rare. We examined the 6-year incidence of CVD and its risk factors in first- and second-generation ethnic Indian ... Full text Link to item Cite

Inter-relationship between ocular perfusion pressure, blood pressure, intraocular pressure profiles and primary open-angle glaucoma: the Singapore Epidemiology of Eye Diseases study.

Journal Article Br J Ophthalmol · October 2018 OBJECTIVE: To elucidate the inter-relationship between ocular perfusion pressure (OPP), blood pressure (BP), intraocular pressure (IOP) profiles and primary open-angle glaucoma (POAG) in a multiethnic Asian population. METHODS: Participants were recruited ... Full text Link to item Cite

Level of tear cytokines in population-level participants and correlation with clinical features.

Journal Article Cytokine · October 2018 AIMS: Tear cytokine levels indicate severity of ocular surface inflammation. Previous reports of cytokine concentrations were based on hospital-based studies or non-Chinese populations. We determine the range of tear concentration of cytokines in a represe ... Full text Link to item Cite

ISPAD Clinical Practice Consensus Guidelines 2018: Microvascular and macrovascular complications in children and adolescents.

Journal Article Pediatr Diabetes · October 2018 Full text Link to item Cite

Age-related macular degeneration.

Journal Article Lancet · September 29, 2018 Age-related macular degeneration is a leading cause of visual impairment and severe vision loss. Clinically, it is classified as early-stage (medium-sized drusen and retinal pigmentary changes) to late-stage (neovascular and atrophic). Age-related macular ... Full text Link to item Cite

Prevalence, Risk Factors, and Impact of Myopic Macular Degeneration on Visual Impairment and Functioning Among Adults in Singapore.

Journal Article Invest Ophthalmol Vis Sci · September 4, 2018 PURPOSE: To determine the prevalence, risk factors, and impact of myopic macular degeneration (MMD) on visual impairment and functioning among adults in Singapore. METHODS: A comprehensive eye examination, including subjective refraction, axial length, and ... Full text Link to item Cite

Aldose Reductase Polymorphisms, Fasting Blood Glucose, and Age-Related Cortical Cataract.

Journal Article Invest Ophthalmol Vis Sci · September 4, 2018 PURPOSE: To determine whether there is an association between polymorphisms of the AKR1B1 gene and cortical cataract in the presence of hyperglycemia. METHODS: In the second cross section of the Blue Mountains Eye Study (BMES), 3508 participants (2334 at 5 ... Full text Link to item Cite

COMPARISON OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHIC CHANGES AFTER ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY ALONE OR IN COMBINATION WITH PHOTODYNAMIC THERAPY IN POLYPOIDAL CHOROIDAL VASCULOPATHY.

Journal Article Retina · September 2018 PURPOSE: To compare changes in optical coherence tomography angiography in eyes with polypoidal choroidal vasculopathy after treatment with anti-vascular endothelial growth factor monotherapy or combined with photodynamic therapy. METHODS: This is a longit ... Full text Link to item Cite

Diet soft drink is associated with increased odds of proliferative diabetic retinopathy.

Journal Article Clin Exp Ophthalmol · September 2018 IMPORTANCE: While consumption of soft drink may increase the risk of cardiovascular disease, the relationship between soft drink consumption and diabetes complications is unknown. BACKGROUND: To explore the association between regular and diet soft drink c ... Full text Link to item Cite

Impact of Incidence and Progression of Diabetic Retinopathy on Vision-Specific Functioning.

Journal Article Ophthalmology · September 2018 PURPOSE: To investigate the independent impact of the incidence and progression of diabetic retinopathy (DR) on visual functioning (VF). DESIGN: Population-based cohort study. PARTICIPANTS: A total of 518 participants aged 40 to 80 years (baseline visit 20 ... Full text Link to item Cite

Diet and risk of myopia in three-year-old Singapore children: the GUSTO cohort.

Journal Article Clin Exp Optom · September 2018 BACKGROUND: To investigate the relationship between dietary intakes at six, nine and 12 months and risk of myopia in three-year-old children in a birth cohort. METHODS: Three hundred and seventeen children from the Growing Up in Singapore Towards Healthy O ... Full text Link to item Cite

The effect of pre-eclampsia on retinal microvascular caliber at delivery and post-partum

Journal Article Obstetric Medicine · September 1, 2018 Background: The retinal microcirculation provides a unique view of microvessel structure by means of non-invasive, retinal image analysis. The aim of the study was to compare the retinal vessel caliber at delivery and one-year post-partum between women who ... Full text Cite

A novel model of persistent retinal neovascularization for the development of sustained anti-VEGF therapies.

Journal Article Exp Eye Res · September 2018 Anti-vascular endothelial growth factor (VEGF) therapies lead to a major breakthrough in treatment of neovascular retinal diseases such as age-related macular degeneration or diabetic retinopathy. Current management of these conditions require regular and ... Full text Link to item Cite

Correlation of Color Fundus Photograph Grading with Risks of Early Age-related Macular Degeneration by using Automated OCT-derived Drusen Measurements.

Journal Article Sci Rep · August 28, 2018 We evaluated automated OCT-derived drusen volume measures in a population-based study (n = 4,512) aged ≥40 years, and its correlation with conventional color fundus photographs (CFP)-derived early AMD features. Participants had protocol-based assessment to ... Full text Link to item Cite

Correlation of Color Fundus Photograph Grading with Risks of Early Age-related Macular Degeneration by using Automated OCT-derived Drusen Measurements

Journal Article SCIENTIFIC REPORTS · August 28, 2018 Full text Link to item Cite

Trends of Visual Impairment and Blindness in the Singapore Chinese Population over a Decade.

Journal Article Sci Rep · August 15, 2018 We evaluated the prevalence of visual impairment (VI) and blindness among Chinese adults in the Singapore Chinese Eye Study (SCES, 2009-2011), and compared the trends with the Tanjong Pagar Survey, Singapore (TPS), conducted a decade earlier. The SCES comp ... Full text Link to item Cite

Macular thickness profile and diabetic retinopathy: the Singapore Epidemiology of Eye Diseases Study.

Journal Article Br J Ophthalmol · August 2018 BACKGROUND: To evaluate retinal thickness profiles in eyes with and without diabetic retinopathy (DR) using spectral-domain optical coherence tomography (SD-OCT) among individuals with diabetes. METHODS: Participants were recruited from the Singapore Epide ... Full text Link to item Cite

Incidence of Fellow Eye Involvement in Patients With Unilateral Exudative Age-Related Macular Degeneration.

Journal Article JAMA Ophthalmol · August 1, 2018 IMPORTANCE: Since the advent of optical coherence tomography angiography (OCT-A), nonexudative neovascularization has been described in the fellow eyes of unilateral exudative age-related macular degeneration (AMD). However, there is limited literature des ... Full text Link to item Cite

Retinal Arteriolar Narrowing in Young Adults With Glaucomatous Optic Disc.

Journal Article J Glaucoma · August 2018 PURPOSE: Glaucomatous optic disc (GOD) might represent various subclinical processes. However, whether the presence of GOD is related to vascular processes is less clear. This study aimed to assess the retinal vessel diameter, as surrogate markers of vascu ... Full text Link to item Cite

Macro- and Microvascular Parameters After Toxic Shock Syndrome.

Journal Article Pediatr Infect Dis J · August 2018 Whether individuals who had toxic shock syndrome in childhood have differences in macro- and retinal microvascular parameters indicative of increased cardiovascular risk is unknown. We found no evidence of adverse macrovascular changes in 22 toxic shock sy ... Full text Link to item Cite

Reply.

Journal Article Am J Ophthalmol · August 2018 Full text Link to item Cite

Global prevalence of visual impairment associated with myopic macular degeneration and temporal trends from 2000 through 2050: systematic review, meta-analysis and modelling.

Journal Article Br J Ophthalmol · July 2018 PURPOSE: We used systematic review and meta-analysis to identify and assimilate evidence quantifying blindness and visual impairment (VI) associated with myopic macular degeneration (MMD), then derived models to predict global patterns. The models were use ... Full text Link to item Cite

Efficacy and Safety of Intravitreal Aflibercept for Polypoidal Choroidal Vasculopathy in the PLANET Study: A Randomized Clinical Trial.

Journal Article JAMA Ophthalmol · July 1, 2018 IMPORTANCE: Polypoidal choroidal vasculopathy (PCV) is common in Asian populations, but an optimal treatment approach remains to be confirmed. OBJECTIVE: To evaluate intravitreal aflibercept injection (IAI) in participants with PCV and compare IAI monother ... Full text Link to item Cite

Clinical Use of Optical Coherence Tomography Angiography in Diabetic Retinopathy Treatment: Ready for Showtime?

Journal Article JAMA Ophthalmol · July 1, 2018 Full text Link to item Cite

Inter-relationship between visual symptoms, activity limitation and psychological functioning in patients with diabetic retinopathy.

Journal Article Br J Ophthalmol · July 2018 AIMS: We explored the direct and indirect impact of restrictions in daily living activities on the relationship between perceived visual symptoms associated with diabetic retinopathy (DR) and psychological functioning. METHODS: In this prospective, cross-s ... Full text Link to item Cite